pax_global_header00006660000000000000000000000064150751655020014520gustar00rootroot0000000000000052 comment=0859b3579f5a0bd7a478c5405fb876a989e3b386 pypdf-6.1.2/000077500000000000000000000000001507516550200126505ustar00rootroot00000000000000pypdf-6.1.2/.git-blame-ignore-revs000066400000000000000000000007501507516550200167520ustar00rootroot00000000000000# This file helps us to ignore style / formatting / doc changes # in git blame. That is useful when we're trying to find the root cause of an # error. # Docstring formatting a89ff74d8c0203278a039d9496a3d8df4d134f84 # STY: Apply pre-commit (black, isort) + use snake_case variables (#832) eef03d935dfeacaa75848b39082cf94d833d3174 # STY: Apply black and isort baeb7d23278de0f8d00ca9f2b656bf0674f08937 # STY: Documentation, Variable names (#839) 444fca22836df061d9d23e71ffb7d68edcdfa766 pypdf-6.1.2/.github/000077500000000000000000000000001507516550200142105ustar00rootroot00000000000000pypdf-6.1.2/.github/ISSUE_TEMPLATE/000077500000000000000000000000001507516550200163735ustar00rootroot00000000000000pypdf-6.1.2/.github/ISSUE_TEMPLATE/bug-report.md000066400000000000000000000013471507516550200210100ustar00rootroot00000000000000--- name: Report a bug about: Something broke! title: '' labels: Bug assignees: '' --- Replace this: What happened? What were you trying to achieve? ## Environment Which environment were you using when you encountered the problem? ```bash $ python -m platform # TODO: Your output goes here $ python -c "import pypdf;print(pypdf._debug_versions)" # TODO: Your output goes here ``` ## Code + PDF This is a minimal, complete example that shows the issue: ```python # TODO: Your code goes here ``` Share here the PDF file(s) that cause the issue. The smaller they are, the better. Let us know if we may add them to our tests! ## Traceback This is the complete traceback I see: ``` # TODO: Your traceback goes here (if applicable) ``` pypdf-6.1.2/.github/ISSUE_TEMPLATE/feature-request.md000066400000000000000000000005551507516550200220430ustar00rootroot00000000000000--- name: Request a Feature about: What do you think is missing in pypdf? title: '' labels: Feature Request assignees: '' --- ## Explanation Explain briefly what you want to achieve. ## Code Example How would your feature be used? (Remove this if it is not applicable.) ```python from pypdf import PdfReader, PdfWriter ... # your new feature in action! ``` pypdf-6.1.2/.github/SECURITY.md000066400000000000000000000015511507516550200160030ustar00rootroot00000000000000# Security Policy ## Supported Versions Security fixes are applied to the latest version. ## Reporting a Vulnerability If you find a potential security issue, please report it using the [private vulnerability reporting](https://docs.github.com/en/code-security/security-advisories/guidance-on-reporting-and-writing-information-about-vulnerabilities/privately-reporting-a-security-vulnerability) feature of GitHub to automatically inform all relevant team members. Otherwise, please get in touch with stefan6419846 through e-mail (current maintainer, address in GitHub profile). We will try to find a fix in a timely manner and will then issue a security advisory together with the update via GitHub ([example](https://github.com/py-pdf/pypdf/security/advisories/GHSA-xcjx-m2pj-8g79)). If you don't get a reaction within 30 days, please open a public issue on GitHub. pypdf-6.1.2/.github/dependabot.yaml000066400000000000000000000003101507516550200171730ustar00rootroot00000000000000# Set update schedule for GitHub Actions version: 2 updates: - package-ecosystem: "github-actions" directory: "/" schedule: interval: "daily" commit-message: prefix: "DEV" pypdf-6.1.2/.github/scripts/000077500000000000000000000000001507516550200156775ustar00rootroot00000000000000pypdf-6.1.2/.github/scripts/check_pr_title.py000066400000000000000000000015751507516550200212400ustar00rootroot00000000000000"""Check that all PR titles follow the desired scheme.""" # noqa: INP001 import os import sys KNOWN_PREFIXES = ( "SEC: ", "BUG: ", "ENH: ", "DEP: ", "PI: ", "ROB: ", "DOC: ", "TST: ", "DEV: ", "STY: ", "MAINT: ", "REL: ", # For internal use only. ) PR_TITLE = os.getenv("PR_TITLE", "") if not PR_TITLE.startswith(KNOWN_PREFIXES) or not PR_TITLE.split(": ", maxsplit=1)[1]: sys.stderr.write( f"The PR title '{PR_TITLE}' does not follow the projects naming scheme: " "https://pypdf.readthedocs.io/en/latest/dev/intro.html#commit-messages\n", ) sys.stderr.write( "If you do not know which one to choose or if multiple apply, make a best guess. " "Nobody will complain if it does not quite fit :-)\n", ) sys.exit(1) else: sys.stdout.write(f"PR title '{PR_TITLE}' appears to be valid.\n") pypdf-6.1.2/.github/workflows/000077500000000000000000000000001507516550200162455ustar00rootroot00000000000000pypdf-6.1.2/.github/workflows/benchmark.yaml000066400000000000000000000025231507516550200210650ustar00rootroot00000000000000name: Benchmarking pypdf on: push: branches: - main permissions: contents: write deployments: write jobs: benchmark: name: Run pytest-benchmark runs-on: ubuntu-latest strategy: matrix: python-version: ["3.x"] steps: - name: Checkout Code uses: actions/checkout@v5 with: submodules: 'recursive' - name: Setup Python uses: actions/setup-python@v6 with: python-version: ${{ matrix.python-version }} - name: Install requirements run: | pip install -r requirements/ci-3.11.txt - name: Install pypdf run: | pip install . - name: Run benchmark run: | pytest tests/bench.py --benchmark-json output.json - name: Store benchmark result uses: benchmark-action/github-action-benchmark@v1 with: name: Python Benchmark with pytest-benchmark tool: 'pytest' output-file-path: output.json # Use personal access token instead of GITHUB_TOKEN due to https://github.community/t/github-action-not-triggering-gh-pages-upon-push/16096 github-token: ${{ secrets.GITHUB_TOKEN }} auto-push: true # Show alert with commit comment on detecting possible performance regression alert-threshold: '200%' comment-on-alert: true fail-on-alert: true pypdf-6.1.2/.github/workflows/create-github-release.yaml000066400000000000000000000021511507516550200232710ustar00rootroot00000000000000name: Create a GitHub release page on: push: tags: - '*.*.*' workflow_dispatch: permissions: contents: write jobs: build_and_publish: name: Create a GitHub release page runs-on: ubuntu-latest steps: - name: Checkout Repository uses: actions/checkout@v5 - name: Prepare variables id: prepare_variables run: | git fetch --tags --force latest_tag=$(git describe --tags --abbrev=0) echo "latest_tag=${latest_tag}" >> "$GITHUB_ENV" echo "date=$(date +'%Y-%m-%d')" >> "$GITHUB_ENV" EOF=$(dd if=/dev/urandom bs=15 count=1 status=none | base64) echo "tag_body<<$EOF" >> "$GITHUB_ENV" git --no-pager tag -l "${latest_tag}" --format='%(contents:body)' >> "$GITHUB_ENV" echo "$EOF" >> "$GITHUB_ENV" - name: Create GitHub Release 🚀 uses: softprops/action-gh-release@v2 with: tag_name: ${{ env.latest_tag }} name: Version ${{ env.latest_tag }}, ${{ env.date }} draft: false prerelease: false body: ${{ env.tag_body }} pypdf-6.1.2/.github/workflows/github-ci.yaml000066400000000000000000000174521507516550200210150ustar00rootroot00000000000000# This workflow will install Python dependencies, run tests and lint with a variety of Python versions # For more information see: https://help.github.com/actions/language-and-framework-guides/using-python-with-github-actions name: CI on: push: branches: - main paths-ignore: - '**/*.md' - '**/*.rst' pull_request: branches: - main paths-ignore: - '**/*.md' - '**/*.rst' workflow_dispatch: jobs: test_windows: name: pytest on windows runs-on: windows-latest steps: - name: Checkout Code uses: actions/checkout@v5 with: submodules: 'recursive' - name: Setup Python (3.11+) uses: actions/setup-python@v6 with: python-version: 3.14 # latest stable python allow-prereleases: true - name: Upgrade pip run: | python -m pip install --upgrade pip - name: Install requirements (Python 3.11+) run: | pip install -r requirements/ci-3.11.txt - name: Install cryptography run: | pip install cryptography - name: Install pypdf run: | pip install . - name: Prepare run: | python -c "from tests import download_test_pdfs; download_test_pdfs()" - name: Test with pytest run: | python -m pytest tests --cov=pypdf --cov-append -n auto -vv -p no:benchmark tests: name: "pytest on ${{ matrix.python-version }} (crypto-lib: ${{ matrix.use-crypto-lib }})" runs-on: ubuntu-22.04 strategy: matrix: python-version: ["3.9", "3.10", "3.11", "3.12", "3.13", "3.14"] use-crypto-lib: ["cryptography"] include: - python-version: "3.9" use-crypto-lib: "pycryptodome" - python-version: "3.9" use-crypto-lib: "none" steps: - name: Update APT packages run: sudo apt-get update - name: Install APT dependencies run: sudo apt-get install ghostscript jbig2dec poppler-utils - name: Checkout Code uses: actions/checkout@v5 with: submodules: 'recursive' - name: Cache Downloaded Files id: cache-downloaded-files uses: actions/cache@v4 with: path: '**/tests/pdf_cache/*' key: cache-downloaded-files - name: Setup Python uses: actions/setup-python@v6 if: matrix.python-version == '3.9' || matrix.python-version == '3.10' with: python-version: ${{ matrix.python-version }} cache: 'pip' cache-dependency-path: '**/requirements/ci.txt' - name: Setup Python (3.11+) uses: actions/setup-python@v6 if: matrix.python-version != '3.9' && matrix.python-version != '3.10' with: python-version: ${{ matrix.python-version }} allow-prereleases: true cache: 'pip' cache-dependency-path: '**/requirements/ci-3.11.txt' - name: Upgrade pip run: | python -m pip install --upgrade pip - name: Install requirements (Python 3) run: | pip install -r requirements/ci.txt if: matrix.python-version == '3.9' || matrix.python-version == '3.10' - name: Install requirements (Python 3.11+) run: | pip install -r requirements/ci-3.11.txt if: matrix.python-version != '3.9' && matrix.python-version != '3.10' - name: Remove pycryptodome and cryptography run: | pip uninstall pycryptodome cryptography -y - name: Install cryptography run: | pip install cryptography if: matrix.use-crypto-lib == 'cryptography' - name: Install pycryptodome run: | pip install pycryptodome if: matrix.use-crypto-lib == 'pycryptodome' - name: Install pypdf run: | pip install . - name: Download test files run: | python -c "from tests import download_test_pdfs; download_test_pdfs()" - name: Setup sitecustomize.py for coverage run: | SITE_PACKAGES="$(python -m site --user-site)" SITECUSTOMIZE_PATH="$SITE_PACKAGES/sitecustomize.py" mkdir -p $SITE_PACKAGES touch $SITECUSTOMIZE_PATH echo "try:" >> $SITECUSTOMIZE_PATH echo " import coverage" >> $SITECUSTOMIZE_PATH echo " coverage.process_startup()" >> $SITECUSTOMIZE_PATH echo "except ImportError:" >> $SITECUSTOMIZE_PATH echo " pass" >> $SITECUSTOMIZE_PATH - name: Test with pytest run: | python -m pytest tests --cov=pypdf --cov-append -n auto -vv -p no:benchmark env: COVERAGE_PROCESS_START: 'pyproject.toml' - name: Rename coverage data file run: mv .coverage ".coverage.$RANDOM" - name: Upload coverage data uses: actions/upload-artifact@v4 with: name: coverage-data.${{ matrix.python-version }}-${{ matrix.use-crypto-lib }} path: .coverage.* if-no-files-found: ignore include-hidden-files: true codestyle: name: Check code style issues runs-on: ubuntu-22.04 steps: - name: Checkout Code uses: actions/checkout@v5 with: submodules: 'recursive' - name: Setup Python 3.11 uses: actions/setup-python@v6 with: python-version: "3.11" cache: 'pip' cache-dependency-path: '**/requirements/ci-3.11.txt' - name: Upgrade pip run: | python -m pip install --upgrade pip - name: Install requirements run: | pip install -r requirements/ci-3.11.txt - name: Install pypdf run: | pip install . - name: Test with ruff run: | echo `ruff --version` ruff check . - name: Test with mypy run : | mypy pypdf - name: Test docs build run: | pip install -r requirements/docs.txt sphinx-build --nitpicky --fail-on-warning --keep-going --show-traceback --builder html docs build/sphinx/html - name: Check with pre-commit run: | pip install -r requirements/dev.txt pre-commit run --all-files --show-diff-on-failure package: name: Build & verify package runs-on: ubuntu-latest steps: - uses: actions/checkout@v5 - uses: actions/setup-python@v6 with: python-version: ${{ env.PYTHON_LATEST }} - run: python -m pip install flit check-wheel-contents - run: flit build - run: ls -l dist - name: Test CHANGELOG.md present in sdist run: tar -tzf dist/*.tar.gz | grep -q 'CHANGELOG.md' - name: Test of bdist run: check-wheel-contents dist/*.whl - name: Test installing package run: python -m pip install . - name: Test running installed package working-directory: /tmp run: python -c "import pypdf;print(pypdf.__version__)" coverage: name: Combine & check coverage. runs-on: ubuntu-latest needs: tests steps: - uses: actions/checkout@v5 - uses: actions/setup-python@v6 with: # Use the latest Python, so it understands all syntax. python-version: ${{ env.PYTHON_LATEST }} - run: python -m pip install --upgrade coverage[toml] - uses: actions/download-artifact@v5 with: pattern: coverage-data* merge-multiple: true - name: Check Number of Downloaded Files run: | downloaded_files_count=$(find \.coverage* -type f | wc -l) if [ $downloaded_files_count -eq 8 ]; then echo "The expected number of files (8) were downloaded." else echo "ERROR: Expected 8 files, but found $downloaded_files_count files." exit 1 fi - name: Combine coverage & create xml report run: | python -m coverage combine python -m coverage xml - name: Upload Coverage to Codecov uses: codecov/codecov-action@v5 with: token: ${{ secrets.CODECOV_TOKEN }} files: ./coverage.xml pypdf-6.1.2/.github/workflows/publish-to-pypi.yaml000066400000000000000000000022551507516550200222020ustar00rootroot00000000000000name: Publish Python Package to PyPI on: push: tags: - '*.*.*' workflow_dispatch: jobs: build: name: Build distribution runs-on: ubuntu-latest steps: - uses: actions/checkout@v5 - name: Set up Python uses: actions/setup-python@v6 with: python-version: "3.x" - name: Install pypa/build run: >- python3 -m pip install build --user - name: Build a binary wheel and a source tarball run: python3 -m build - name: Store the distribution packages uses: actions/upload-artifact@v4 with: name: python-package-distributions path: dist/ publish-to-pypi: name: Publish Python distribution to PyPI needs: - build runs-on: ubuntu-latest environment: name: pypi url: https://pypi.org/p/pypdf permissions: id-token: write # IMPORTANT: mandatory for trusted publishing steps: - name: Download all the dists uses: actions/download-artifact@v5 with: name: python-package-distributions path: dist/ - name: Publish distribution to PyPI uses: pypa/gh-action-pypi-publish@release/v1 pypdf-6.1.2/.github/workflows/release.yaml000066400000000000000000000033101507516550200205460ustar00rootroot00000000000000# This action assumes that there is a REL-commit which already has a # Markdown-formatted git tag. Hence, the CHANGELOG is already adjusted, # and it's decided what should be in the release. # This action only ensures the release is done with the proper contents # and that it's announced with a GitHub release. name: Create git tag on: push: branches: - main permissions: contents: write env: HEAD_COMMIT_MESSAGE: ${{ github.event.head_commit.message }} jobs: build_and_publish: name: Publish a new version runs-on: ubuntu-latest if: "${{ startsWith(github.event.head_commit.message, 'REL: ') }}" steps: - name: Checkout Repository uses: actions/checkout@v5 - name: Extract version from commit message id: extract_version run: | VERSION=$(echo "$HEAD_COMMIT_MESSAGE" | grep -oP '(?<=REL: )\d+\.\d+\.\d+') echo "version=$VERSION" >> $GITHUB_OUTPUT - name: Extract tag message from commit message id: extract_message run: | VERSION="${{ steps.extract_version.outputs.version }}" delimiter="$(openssl rand -hex 8)" MESSAGE=$(echo "$HEAD_COMMIT_MESSAGE" | sed "0,/REL: $VERSION/s///" ) echo "message<<${delimiter}" >> $GITHUB_OUTPUT echo "$MESSAGE" >> $GITHUB_OUTPUT echo "${delimiter}" >> $GITHUB_OUTPUT - name: Create Git Tag run: | VERSION="${{ steps.extract_version.outputs.version }}" MESSAGE="${{ steps.extract_message.outputs.message }}" git config user.name github-actions git config user.email github-actions@github.com git tag "$VERSION" -m "$MESSAGE" git push origin $VERSION pypdf-6.1.2/.github/workflows/title-check.yaml000066400000000000000000000010251507516550200213230ustar00rootroot00000000000000name: 'PR Title Check' on: pull_request: # check when PR # * is created, # * title is edited, and # * new commits are added (to ensure failing title blocks merging) types: [opened, reopened, edited, synchronize] jobs: title-check: name: Title check runs-on: ubuntu-latest steps: - name: Checkout Code uses: actions/checkout@v5 - name: Check PR title env: PR_TITLE: ${{ github.event.pull_request.title }} run: python .github/scripts/check_pr_title.py pypdf-6.1.2/.gitignore000066400000000000000000000010011507516550200146300ustar00rootroot00000000000000*.pyc *.swp .DS_Store .tox build .idea/* *.egg-info/ dist/* __pycache__/ # in-project virtual environments venv/ .venv/ # Code coverage artifacts .coverage* coverage.xml # Editors / IDEs .vscode/ # Docs docs/_build/ .cspell/ # Files generated by some of the scripts dont_commit_*.pdf pypdf-output.pdf annotated-pdf-link.pdf Image9.png pypdf_pdfLocation.txt .python-version tests/pdf_cache/ docs/meta/CHANGELOG.md docs/meta/CONTRIBUTORS.md extracted-images/ RELEASE_COMMIT_MSG.md RELEASE_TAG_MSG.md .envrc pypdf-6.1.2/.gitmodules000066400000000000000000000001361507516550200150250ustar00rootroot00000000000000[submodule "sample-files"] path = sample-files url = https://github.com/py-pdf/sample-files pypdf-6.1.2/.pre-commit-config.yaml000066400000000000000000000017621507516550200171370ustar00rootroot00000000000000# pre-commit run --all-files repos: - repo: https://github.com/pre-commit/pre-commit-hooks rev: v6.0.0 hooks: - id: check-ast - id: check-case-conflict - id: check-docstring-first - id: check-yaml - id: debug-statements - id: end-of-file-fixer exclude: "resources/.*|docs/make.bat" - id: fix-byte-order-marker - id: trailing-whitespace - id: mixed-line-ending args: ['--fix=lf'] exclude: "docs/make.bat" - id: check-added-large-files args: ['--maxkb=1000'] - repo: https://github.com/charliermarsh/ruff-pre-commit rev: v0.13.0 hooks: - id: ruff-check args: ['--fix'] - repo: https://github.com/asottile/pyupgrade rev: v3.20.0 hooks: - id: pyupgrade args: [--py39-plus] - repo: https://github.com/pre-commit/mirrors-mypy rev: v1.17.1 hooks: - id: mypy additional_dependencies: [types-Pillow==10.2.0.20240822] files: ^pypdf/.* pypdf-6.1.2/.readthedocs.yaml000066400000000000000000000010401507516550200160720ustar00rootroot00000000000000# See https://docs.readthedocs.io/en/stable/config-file/v2.html for details version: 2 build: os: ubuntu-22.04 tools: python: "3.12" # Build documentation in the "docs/" directory with Sphinx sphinx: configuration: docs/conf.py # If using Sphinx, optionally build your docs in additional formats such as PDF formats: all # Optionally declare the Python requirements required to build your docs python: install: - requirements: requirements/docs.txt - method: pip path: . extra_requirements: - full pypdf-6.1.2/CHANGELOG.md000066400000000000000000002021131507516550200144600ustar00rootroot00000000000000# CHANGELOG ## Version 6.1.2, 2025-10-19 ### Bug Fixes (BUG) - Fix handling of zero-length StreamObject (#3485) ### Robustness (ROB) - Deal with wrong size for incremental PDF files (#3495) - Improve handling for malformed cross-reference tables (#3483) ### Developer Experience (DEV) - Use released Python 3.14 - Use Mapping instead of dict in type hint of update_page_form_field_values (#3490) [Full Changelog](https://github.com/py-pdf/pypdf/compare/6.1.1...6.1.2) ## Version 6.1.1, 2025-09-28 ### Bug Fixes (BUG) - Insert new embedded files in a sorted manner (#3477) - Fix name tree handling for embedded files with Kids-based inputs (#3475) - Make embedding files not break PDF/A-3 compliance (#3472) ### Documentation (DOC) - Document AFRelationship handling for PDF/A and provide constants (#3478) [Full Changelog](https://github.com/py-pdf/pypdf/compare/6.1.0...6.1.1) ## Version 6.1.0, 2025-09-21 ### New Features (ENH) - Enhance XMP metadata handling with creation and setter methods (#3410) - Add all font metrics for base 14 Type 1 PDF fonts (#3363) - Allow deleting embedded files (#3461) - Add support for Python in FIPS mode for document identifier (#3438) ### Bug Fixes (BUG) - Fix handling of UTF-16 encoded destination titles (#3463) - Guard empty input to prevent IndexError (#3448) ### Developer Experience (DEV) - Fix type hint for XMP metadata setter to add bytes type (#3464) [Full Changelog](https://github.com/py-pdf/pypdf/compare/6.0.0...6.1.0) ## Version 6.0.0, 2025-08-11 ### Security (SEC) - Limit decompressed size for FlateDecode filter (#3430) ### Deprecations (DEP) - Drop Python 3.8 support (#3412) ### New Features (ENH) - Move BlackIs1 functionality to tiff_header (#3421) ### Robustness (ROB) - Skip Go-To actions without a destination (#3420) ### Developer Experience (DEV) - Update code style related libraries (#3414) - Update mypy to 1.17.0 (#3413) - Stop testing on Python 3.8 and start testing on Python 3.14 (#3411) ### Maintenance (MAINT) - Cleanup deprecations (#3424) [Full Changelog](https://github.com/py-pdf/pypdf/compare/5.9.0...6.0.0) ## Version 5.9.0, 2025-07-27 ### New Features (ENH) - Automatically preserve links in added pages (#3298) - Allow writing/updating all properties of an embedded file (#3374) ### Bug Fixes (BUG) - Fix XMP handling dropping indirect references (#3392) ### Robustness (ROB) - Deal with DecodeParms being empty list (#3388) ### Documentation (DOC) - Document how to read and modify XMP metadata (#3383) [Full Changelog](https://github.com/py-pdf/pypdf/compare/5.8.0...5.9.0) ## Version 5.8.0, 2025-07-13 ### New Features (ENH) - Implement flattening for writer (#3312) ### Bug Fixes (BUG) - Unterminated object when using PdfWriter with incremental=True (#3345) ### Robustness (ROB) - Resolve some image extraction edge cases (#3371) - Ignore faulty trailing newline during RLE decoding (#3355) - Gracefully handle odd-length strings in parse_bfchar (#3348) ### Developer Experience (DEV) - Modernize license specifiers (#3338) ### Maintenance (MAINT) - Reduce max-complexity of tool.ruff.lint.mccabe (#3365) - Refactor text extraction code [Full Changelog](https://github.com/py-pdf/pypdf/compare/5.7.0...5.8.0) ## Version 5.7.0, 2025-06-29 ### Performance Improvements (PI) - Performance optimization for LZW decoding (#3329) ### Robustness (ROB) - Flate decoding for streams with faulty tail bytes (#3332) - dc_creator could be a Bag as well (#3333) - Handle tree being NullObject when retrieving named destinations (#3331) ### Maintenance (MAINT) - Move inline-image mappings to constants (#3328) [Full Changelog](https://github.com/py-pdf/pypdf/compare/5.6.1...5.7.0) ## Version 5.6.1, 2025-06-22 ### New Features (ENH) - Add PDF/A XMP metadata support (#3314) ### Robustness (ROB) - Deal with annotations not being lists on merge (#3321) - Handle NullObject for cmap encoding Differences entry (#3317) ### Developer Experience (DEV) - Update ruff to 0.12.0 (#3316) [Full Changelog](https://github.com/py-pdf/pypdf/compare/5.6.0...5.6.1) ## Version 5.6.0, 2025-06-01 ### New Features (ENH) - Add basic support for JBIG2 by using jbig2dec (#3163) ### Bug Fixes (BUG) - Fix crashes by removing unnecessary line (#3293) - Add delimiters to NameObject.renumber_table (#3286) ### Robustness (ROB) - Handle DecodeParms being a NullObject (#3285) ### Code Style (STY) - Update to mypy 1.16.0 (#3300) [Full Changelog](https://github.com/py-pdf/pypdf/compare/5.5.0...5.6.0) ## Version 5.5.0, 2025-05-11 ### New Features (ENH) - Add support for IndirectObject.__iter__ (#3228) - Allow filtering by font when removing text (#3216) ### Bug Fixes (BUG) - Add missing named destinations being ByteStringObjects (#3282) - Get font information more reliably when removing text (#3252) - T* 2D Translation consistent with PDF 1.7 Spec (#3250) - Add font stack to q/Q operations in layout mode (#3225) - Avoid completely hiding image loading issues like exceeding image size limits (#3221) - Using compress_identical_objects on transformed content duplicates differing content (#3197) - Consider BlackIs1 parameter for CCITTFaxDecode filter (#3196) ### Robustness (ROB) - Deal with insufficient cm matrix during text extraction (#3283) - Allow merging when annotations miss D entry (#3281) - Fix merging documents if there are no Dests (#3280) - Fix crash on malformed action in outline (#3278) - Fix compression issues for removed images which might be None (#3246) - Attempt to deal with non-rectangular FlateDecode streams (#3245) - Handle some None values for broken PDF files (#3230) ### Developer Experience (DEV) - Multiple style improvements - Update ruff to 0.11.0 ### Maintenance (MAINT) - Conform ASCIIHexDecode implementation to specification (#3274) - Modify comments of filters that do not use decode_parms (#3260) ### Code Style (STY) - Simplify warnings & debugging in layout mode text extraction (#3271) - Standardize mypy assert statements (#3276) [Full Changelog](https://github.com/py-pdf/pypdf/compare/5.4.0...5.5.0) ## Version 5.4.0, 2025-03-16 ### New Features (ENH) - Add support for `IndirectObject.__contains__` (#3155) ### Bug Fixes (BUG) - Fix detection of inline images followed by names or numbers (#3173) ### Robustness (ROB) - Consider root objects without catalog type as fallback (#3175) - Raise proper error on infinite loop when reading objects (#3169) ### Documentation (DOC) - Mention memory consumption of text extraction (#3168) ### Developer Experience (DEV) - Upgrade to ruff 0.10.0 (#3191) [Full Changelog](https://github.com/py-pdf/pypdf/compare/5.3.1...5.4.0) ## Version 5.3.1, 2025-03-02 ### Bug Fixes (BUG) - Use the correct name StandardEncoding for the predefined cmap (#3156) - Handle inline images containing `EI ` sequences (#3152) - Fix check box value which should be name object (#3124) - Fix stream position on inline image fallback extraction (#3120) - Fix object count for incremental writer (#3117) ### Robustness (ROB) - Avoid index errors on empty lines in xref table (#3162) - Improve handling of LZW decoder table overflow (#3159) - Ignore non-numbers for width when building font width map (#3158) - Avoid negative seek values when reading partially broken files (#3157) ### Documentation (DOC) - Fixed PageObject.images example usage for replacing image (#3149) [Full Changelog](https://github.com/py-pdf/pypdf/compare/5.3.0...5.3.1) ## Version 5.3.0, 2025-02-09 ### New Features (ENH) - Handle attachments in /Kids and provide object-oriented API (#3108) ### Bug Fixes (BUG) - Handle annotations being None on merging (#3111) ### Robustness (ROB) - Prevent excessive layout mode text output from Type3 fonts (#3082) ### Documentation (DOC) - stefan6419846 becomes BDFL of pypdf (#3078) - Tidy the visitor function description (#3086) ### Developer Experience (DEV) - Remove ignoring multiple Ruff rules - Remove unused mutmut configuration (#3092) ### Testing (TST) - Fix warning assertions to use `pytest.warns()` (#3083) [Full Changelog](https://github.com/py-pdf/pypdf/compare/5.2.0...5.3.0) ## Version 5.2.0, 2025-01-26 ### Deprecations (DEP) - Deprecate with replacement CCITParameters (#3019) - Correct deprecation of interiour_color (#2947) ### New Features (ENH) - Support alternative (U)F names for embedded file retrieval (#3072) - Adding support for reading .metadata.keywords (#2939) ### Bug Fixes (BUG) - Handle further Tf operators in text extraction layout mode (#3073) - Ensure `add_metadata` can deal with `_info = None` (#3040) - Handle IndirectObject in CCITTFaxDecode filter (#2965) - Handle chained colorspace for inline images when no filter is set (#3008) - Avoid extracting inline images twice and dropping other operators (#3002) - Fixed reference of value with `str.__new__` in TextStringObject (#2952) - Handle indirect objects in font width calculations (#2967) - Title sometimes is bytes and not str (#2930) - Fix undefined variable for text extraction (regression) (#2934) - Don't close stream passed to PdfWriter.write() (#2909) ### Robustness (ROB) - Handle zero height fonts when extracting text (#3075) - Deal with content streams not containing streams (#3005) - Gracefully handle some text operators when the operands are missing (#3006) - Fall back to non-Adobe Ascii85 format for missing end markers (#3007) - Ignore odd-length strings when processing cmap lines (#3009) - Skip annotation destination being NullObject in PdfWriter (#2964) - Skip destination page being None in PdfWriter (#2963) - Fix infinite loop case when reading null objects within an Array - Fixing infinite loop in ArrayObject read_from_stream (#2928) ### Documentation (DOC) - Add note about default line colors (#3014) ### Developer Experience (DEV) - Remove ignoring Ruff rule PGH004 (#3071) - Tidy ignore array in tool.ruff.lint (#3069) - Move Windows CI to Python 3.13 (#3003) - Move to Ubuntu 22.04 (#3004) ### Maintenance (MAINT) - Fix formatting of warning message and include exception message (#3076) - Narrow return type for `ContentStream.operations` (#2941) ### Testing (TST) - Fix image similarity for upcoming Ubuntu 24.04 (#3039) - Replace broken Apache Tika Corpora urls (#3041) ### Code Style (STY) - Add form feed to WHITESPACES (#3054) - Lots of small internal changes [Full Changelog](https://github.com/py-pdf/pypdf/compare/5.1.0...5.2.0) ## Version 5.1.0, 2024-10-27 ### New Features (ENH) - Add `layout_mode_font_height_weight` argument to `PageObject.extract_text()` (#2920) ### Bug Fixes (BUG) - Fix font specificier for FreeText annotation (#2893) - Line breaks are not generated due to incorrect calculation of text leading (#2890) - Improve handling of spaces in text extraction (#2882) ### Robustness (ROB) - Soft failure for flate encode image mode 1 with wrong LUT size (#2900) ### Documentation (DOC) - Use latest package versions (#2907) - Correct example of reading FileAttachment annotation (#2906) ### Developer Experience (DEV) - Update pinned requirements (#2918) - Make make_release.py compatible with Windows environment (#2894) ### Maintenance (MAINT) - Remove references to outdated Python versions (#2919) - Generalize the method of obtaining space_code (#2891) - Unnecessary character mapping process (#2888) - New LZW decoding implementation (#2887) ### Testing (TST) - Add LzwCodec for encoding (#2883) ### Code Style (STY) - Capitalize error messages (#2903) - Modify error messages in PdfWriter (#2902) [Full Changelog](https://github.com/py-pdf/pypdf/compare/5.0.1...5.1.0) ## Version 5.0.1, 2024-09-29 ### New Features (ENH) - Add `full` parameter to PdfWriter constructor (#2865) ### Bug Fixes (BUG) - Update pyproject.toml with minimum Python version of 3.8 (#2859) - Cope with unbalanced delimiters in dictionary object (#2878) - Cope with encoding with too many differences (#2873) - Missing spaces in extract_text() method (#1328) (#2868) - Tolerate truncated files and no warning when jumping startxref (#2855) ### Robustness (ROB) - Repair PDF with invalid Root object (#2880) - Continue parsing dictionary object when error is detected (#2872) - Merge documents with invalid pages in named destinations (#2857) - Tolerate comments in arrays (#2856) ### Developer Experience (DEV) - Use latest Python version for benchmarking (#2879) ### Maintenance (MAINT) - Add tests to source distributions (#2874) - Refactor _update_field_annotation (#2862) [Full Changelog](https://github.com/py-pdf/pypdf/compare/5.0.0...5.0.1) ## Version 5.0.0, 2024-09-15 This version drops support for Python 3.7 (not maintained since July 2023), PdfMerger (use PdfWriter instead) and AnnotationBuilder (use annotations instead). ### Deprecations (DEP) - Remove the deprecated PdfMerger and AnnotationBuilder classes and other deprecations cleanup (#2813) - Drop Python 3.7 support (#2793) ### New Features (ENH) - Add capability to remove /Info from PDF (#2820) - Add incremental capability to PdfWriter (#2811) - Add UniGB-UTF16 encodings (#2819) - Accept utf strings for metadata (#2802) - Report PdfReadError instead of RecursionError (#2800) - Compress PDF files merging identical objects (#2795) ### Bug Fixes (BUG) - Fix sheared image (#2801) ### Robustness (ROB) - Robustify .set_data() (#2821) - Raise PdfReadError when missing /Root in trailer (#2808) - Fix extract_text() issues on damaged PDFs (#2760) - Handle images with empty data when processing an image from bytes (#2786) ### Developer Experience (DEV) - Fix coverage uploads (#2832) - Test against Python 3.13 (#2776) [Full Changelog](https://github.com/py-pdf/pypdf/compare/4.3.1...5.0.0) ## Version 4.3.1, 2024-07-21 ### Bug Fixes (BUG) - Cope with Matrix entry in field annotations (#2736) ### Robustness (ROB) - Cope with fields with upside down box/rectangle (#2729) ### Maintenance (MAINT) - Add deprecate_with_replacement to StreamObject.initializeFromD… (#2728) - Deal with cryptography>=43 moving ARC4 (#2765) [Full Changelog](https://github.com/py-pdf/pypdf/compare/4.3.0...4.3.1) ## Version 4.3.0, 2024-06-23 ### New Features (ENH) - Accept ETen-B5 and UniCNS-UTF16 encodings (#2721) - Add decode_as_image() to ContentStreams (#2615) - context manager for PdfReader (#2666) - Add capability to set font and size in fields (#2636) - Allow to pass input file without named argument (#2576) ### Bug Fixes (BUG) - Fix deprecation for Ressources when using old constants (#2705) - Fix images issue 4 bits encoding and LUT starting with UTF16_BOM (#2675) - Reading large compressed images takes huge time to process (#2644) - Highlighted Text Cannot Be Printed (#2604) - Fix UnboundLocalError on malformed pdf (#2619) ### Robustness (ROB) - Cope with missing Standard 14 fonts in fields (#2677) - Improve inline image extraction (#2622) - Cope with loops in Fields tree (#2656) - Discard /I in choice fields for compatibility with Acrobat (#2614) - Cope with some issues in pillow (#2595) - Cope with some image extraction issues (#2591) ### Documentation (DOC) - Various improvements on docstrings and examples ### Maintenance (MAINT) - Deprecate interiour_color with replacement interior_color (#2706) - Add deprecate_with_replacement to PdfWriter.find_bookmark (#2674) ### Code Style (STY) - Change Link to be a non-markup annotation (#2714) [Full Changelog](https://github.com/py-pdf/pypdf/compare/4.2.0...4.3.0) ## Version 4.2.0, 2024-04-07 ### New Features (ENH) - Allow multiple charsets for NameObject.read_from_stream (#2585) - Add support for /Kids in page labels (#2562) - Allow to update fields on many pages (#2571) - Tolerate PDF with invalid xref pointed objects (#2335) - Add Enforce from PDF2.0 in viewer_preferences (#2511) - Add += and -= operators to ArrayObject (#2510) ### Bug Fixes (BUG) - Fix merge_page sometimes generating unknown operator 'QQ' (#2588) - Fix fields update where annotations are kids of field (#2570) - Process CMYK images without a filter correctly (#2557) - Extract text in layout mode without finding resources (#2555) - Prevent recursive loop in some PDF files (#2505) ### Robustness (ROB) - Tolerate "truncated" xref (#2580) - Replace error by warning for EOD in RunLengthDecode/ASCIIHexDecode (#2334) - Rebuild xref table if one entry is invalid (#2528) - Robustify stream extraction (#2526) ### Documentation (DOC) - Update release process for latest changes (#2564) - Encryption/decryption: Clone document instead of copying all pages (#2546) - Minor improvements (#2542) - Update annotation list (#2534) - Update references and formatting (#2529) - Correct threads reference, plus minor changes (#2521) - Minor readability increases (#2515) - Simplify PaperSize examples (#2504) - Minor improvements (#2501) ### Developer Experience (DEV) - Remove unused dependencies (#2572) - Remove page labels PR link from message (#2561) - Fix changelog generator regarding whitespace and handling of "Other" group (#2492) - Add REL to known PR prefixes (#2554) - Release using the REL commit instead of git tag (#2500) - Unify code between PdfReader and PdfWriter (#2497) - Bump softprops/action-gh-release from 1 to 2 (#2514) ### Maintenance (MAINT) - Ressources → Resources (and internal name childs) (#2550) - Fix typos found by codespell (#2549) - Update Read the Docs configuration (#2538) - Add root_object, _info and _ID to PdfReader (#2495) ### Testing (TST) - Allow loading truncated images if required (#2586) - Fix download issues from #2562 (#2578) - Improve test_get_contents_from_nullobject to show real use-case (#2524) - Add missing test annotations (#2507) [Full Changelog](https://github.com/py-pdf/pypdf/compare/4.1.0...4.2.0) ## Version 4.1.0, 2024-03-03 Generating name objects (`NameObject`) without a leading slash is considered deprecated now. Previously, just a plain warning would be logged, leading to possibly invalid PDF files. According to our deprecation policy, this will log a *DeprecationWarning* for now. ### New Features (ENH) - Add get_pages_from_field (#2494) - Add reattach_fields function (#2480) - Automatic access to pointed object for IndirectObject (#2464) ### Bug Fixes (BUG) - Missing error on name without leading / (#2387) - encode_pdfdocencoding() always returns bytes (#2440) - BI in text content identified as image tag (#2459) ### Robustness (ROB) - Missing basefont entry in type 3 font (#2469) ### Documentation (DOC) - Improve lossless compression example (#2488) - Amend robustness documentation (#2479) ### Developer Experience (DEV) - Fix changelog for UTF-8 characters (#2462) ### Maintenance (MAINT) - Add _get_page_number_from_indirect in writer (#2493) - Remove user assignment for feature requests (#2483) - Remove reference to old 2.0.0 branch (#2482) ### Testing (TST) - Fix benchmark failures (#2481) - Broken test due to expired test file URL (#2468) - Resolve file naming conflict in test_iss1767 (#2445) [Full Changelog](https://github.com/py-pdf/pypdf/compare/4.0.2...4.1.0) ## Version 4.0.2, 2024-02-18 ### Bug Fixes (BUG) - Use NumberObject for /Border elements of annotations (#2451) [Full Changelog](https://github.com/py-pdf/pypdf/compare/4.0.1...4.0.2) ## Version 4.0.1, 2024-01-28 ### Bug Fixes (BUG) - layout mode text extraction ZeroDivisionError (#2417) ### Testing (TST) - Skip tests using fpdf2 if it's not installed (#2419) [Full Changelog](https://github.com/py-pdf/pypdf/compare/4.0.0...4.0.1) ## Version 4.0.0, 2024-01-19 ### Deprecations (DEP) - Drop Python 3.6 support (#2369) - Remove deprecated code (#2367) - Remove deprecated XMP properties (#2386) ### New Features (ENH) - Add "layout" mode for text extraction (#2388) - Add Jupyter Notebook integration for PdfReader (#2375) - Improve/rewrite PDF permission retrieval (#2400) ### Bug Fixes (BUG) - PdfWriter.add_uri was setting the wrong type (#2406) - Add support for GBK2K cmaps (#2385) ### Maintenance (MAINT) - Return None instead of -1 when page is not attached (#2376) - Complete FileSpecificationDictionaryEntries constants (#2416) - Replace warning with logging.error (#2377) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.17.4...4.0.0) ## Version 3.17.4, 2023-12-24 ### Bug Fixes (BUG) - Handle IndirectObject as image filter (#2355) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.17.3...3.17.4) ## Version 3.17.3, 2023-12-17 ### Robustness (ROB) - Out-of-bounds issue in handle_tj (text extraction) (#2342) ### Developer Experience (DEV) - Make make_release.py easier to configure (#2348) ### Maintenance (MAINT) - Bump actions/download-artifact from 3 to 4 (#2344) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.17.2...3.17.3) ## Version 3.17.2, 2023-12-10 ### Bug Fixes (BUG) - Cope with deflated images with CMYK Black Only (#2322) - Handle indirect objects as parameters for CCITTFaxDecode (#2307) - check words length in _cmap type1_alternative function (#2310) ### Robustness (ROB) - Relax flate decoding for too many lookup values (#2331) - Let _build_destination skip in case of missing /D key (#2018) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.17.1...3.17.2) ## Version 3.17.1, 2023-11-14 ### Bug Fixes (BUG) - Mediabox expansion size when applying non-right angle rotation (#2282) ### Robustness (ROB) - MissingWidth is IndirectObject (#2288) - Initialize states array with an empty value (#2280) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.17.0...3.17.1) ## Version 3.17.0, 2023-10-29 ### Security (SEC) - Infinite recursion when using PdfWriter(clone_from=reader) (#2264) ### New Features (ENH) - Add parameter to select images to be removed (#2214) ### Bug Fixes (BUG) - Correctly handle image mode 1 with FlateDecode (#2249) - Error when filling a value with parentheses #2268 (#2269) - Handle empty root outline (#2239) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.16.4...3.17.0) ## Version 3.16.4, 2023-10-10 ### Bug Fixes (BUG) - Avoid exceeding recursion depth when retrieving image mode (#2251) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.16.3...3.16.4) ## Version 3.16.3, 2023-10-08 ### Bug Fixes (BUG) - Invalid cm/tm in visitor functions (#2206) - Encrypt / decrypt Stream object dictionaries (#2228) - Support nested color spaces for the /DeviceN color space (#2241) - Images property fails if NullObject in list (#2215) ### Developer Experience (DEV) - Unify mypy options and warn redundant workarounds (#2223) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.16.2...3.16.3) ## Version 3.16.2, 2023-09-24 ### Bug Fixes (BUG) - PDF size increases because of too high float writing precision (#2213) - Fix test_watermarking_reportlab_rendering() (#2203) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.16.1...3.16.2) ## Version 3.16.1, 2023-09-17 ⚠️ The 'rename PdfWriter.create_viewer_preference to PdfWriter.create_viewer_preferences (#2190)' could be a breaking change for you, if you use it. As it was only introduced last week I'm confident enough that nobody will be affected though. Hence only the patch update. ### Bug Fixes (BUG) - Missing new line in extract_text with cm operations (#2142) - _get_fonts not processing properly CIDFonts and annotations (#2194) ### Maintenance (MAINT) - Rename PdfWriter.create_viewer_preference to PdfWriter.create_viewer_preferences (#2190) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.16.0...3.16.1) ## Version 3.16.0, 2023-09-10 ### Security (SEC) - Infinite recursion caused by IndirectObject clone (#2156) ### New Features (ENH) - Ease access to ViewerPreferences (#2144) ### Bug Fixes (BUG) - Catch the case where w[0] is an IndirectObject instead of an int (#2154) - Cope with indirect objects in filters and remove deprecated code (#2177) - Accept tabs in cmaps (#2174) / cope with extra space (#2151) - Merge pages without resources (#2150) - getcontents() shall return None if contents is NullObject (#2161) - Fix conversion from 1 to LA (#2175) ### Robustness (ROB) - Accept XYZ with no arguments (#2178) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.15.5...3.16.0) ## Version 3.15.5, 2023-09-03 ### Bug Fixes (BUG) - Cope with missing /I in articles (#2134) - Fix image look-up table in EncodedStreamObject (#2128) - remove_images not operating in sub level forms (#2133) ### Robustness (ROB) - Cope with damaged PDF (#2129) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.15.4...3.15.5) ## Version 3.15.4, 2023-08-27 ### Performance Improvements (PI) - Making pypdf as fast as pdfrw (#2086) ### Maintenance (MAINT) - Relax typing_extensions version (#2104) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.15.3...3.15.4) ## Version 3.15.3, 2023-08-26 ### Bug Fixes (BUG) - Check version of crypt provider (#2115) - TypeError: can't concat str to bytes (#2114) - Require flit_core >= 3.9 (#2091) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.15.2...3.15.3) ## Version 3.15.2, 2023-08-20 ### Security (SEC) - Avoid endless recursion of reading damaged PDF file (#2093) ### Performance Improvements (PI) - Reuse content stream (#2101) ### Maintenance (MAINT) - Make ParseError inherit from PyPdfError (#2097) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.15.1...3.15.2) ## Version 3.15.1, 2023-08-13 ### Performance Improvements (PI) - optimize _decode_png_prediction (#2068) ### Bug Fixes (BUG) - Fix incorrect tm_matrix in call to visitor_text (#2060) - Writing German characters into form fields (#2047) - Prevent stall when accessing image in corrupted pdf (#2081) - append() fails when articles do not have /T (#2080) ### Robustness (ROB) - Cope with xref not followed by separator (#2083) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.15.0...3.15.1) ## Version 3.15.0, 2023-08-06 ### New Features (ENH) - Add `level` parameter to compress_content_streams (#2044) - Process /uniHHHH for text_extract (#2043) ### Bug Fixes (BUG) - Fix AnnotationBuilder.link (#2066) - JPX image without ColorSpace (#2062) - Added check for field /Info when cloning reader document (#2055) - Fix indexed/CMYK images (#2039) ### Maintenance (MAINT) - Cryptography as primary dependency (#2053) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.14.0...3.15.0) ## Version 3.14.0, 2023-07-29 ### New Features (ENH) - Accelerate image list keys generation (#2014) - Use `cryptography` for encryption/decryption as a fallback for PyCryptodome (#2000) - Extract LaTeX characters (#2016) - ASCIIHexDecode.decode now returns bytes instead of str (#1994) ### Bug Fixes (BUG) - Add RunLengthDecode filter (#2012) - Process /Separation ColorSpace (#2007) - Handle single element ColorSpace list (#2026) - Process lookup decoded as TextStringObjects (#2008) ### Robustness (ROB) - Cope with garbage collector during cloning (#1841) ### Maintenance (MAINT) - Cleanup of annotations (#1745) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.13.0...3.14.0) ## Version 3.13.0, 2023-07-23 ### New Features (ENH) - Add is_open in outlines in PdfReader and PdfWriter (#1960) ### Bug Fixes (BUG) - Search /DA in hierarchy fields (#2002) - Cope with different ISO date length (#1999) - Decode Black only/CMYK deviceN images (#1984) - Process CMYK in deflate images (#1977) ### Developer Experience (DEV) - Add mypy to pre-commit (#2001) - Release automation (#1991, #1985) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.12.2...3.13.0) ## Version 3.12.2, 2023-07-16 ### Bug Fixes (BUG) - Accept calRGB and calGray color_spaces (#1968) - Process 2bits and 4bits images (#1967) - Check for AcroForm and ensure it is not None (#1965) ### Developer Experience (DEV) - Automate the release process (#1970) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.12.1...3.12.2) ## Version 3.12.1, 2023-07-09 ### Bug Fixes (BUG) - Prevent updating page contents after merging page (stamping/watermarking) (#1952) - % to be hex encoded in names (#1958) - Inverse color in CMYK images (#1947) - Dates conversion not working with Z00\'00\' (#1946) - Support UTF-16-LE Strings (#1884) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.12.0...3.12.1) ## Version 3.12.0, 2023-07-02 ### New Features (ENH) - Add AES support for encrypting PDF files (#1918, #1935, #1936, #1938) - Add page deletion feature to PdfWriter (#1843) ### Bug Fixes (BUG) - PdfReader.get_fields() attempts to delete non-existing index "/Off" (#1933) - Remove unused objects when cloning_from (#1926) - Add the TK.SIZE into the trailer (#1911) - add_named_destination() maintains named destination list sort order (#1930) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.11.1...3.12.0) ## Version 3.11.1, 2023-06-25 ### Bug Fixes (BUG) - Cascaded filters in image objects (#1913) - Append pdf with named destination using numbers for pages (#1858) - Ignore "/B" fields only on pages in PdfWriter.append() (#1875) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.11.0...3.11.1) ## Version 3.11.0, 2023-06-23 ### New Features (ENH) - Add page_number property (#1856) ### Bug Fixes (BUG) - File expansion when updating with Page Contents (#1906) - Missing Alternate in indexed/ICCbased colorspaces (#1896) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.10.0...3.11.0) ## Version 3.10.0, 2023-06-18 ### New Features (ENH) - Extraction of inline images (#1850) - Add capability to replace image (#1849) - Extend images interface by returning an ImageFile(File) class (#1848) - Add set_data to EncodedStreamObject (#1854) ### Bug Fixes (BUG) - Fix RGB FlateEncode Images(PNG) and transparency (#1834) - Generate static appearance for fields (#1864) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.9.1...3.10.0) ## Version 3.9.1, 2023-06-04 ### Deprecations (DEP) - Deprecate PdfMerger (#1866) ### Bug Fixes (BUG) - Ignore UTF-8 decode errors (#1865) ### Robustness (ROB) - Handle missing /Type entry in Page tree (#1859) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.9.0...3.9.1) ## Version 3.9.0, 2023-05-21 ### New Features (ENH) - Simplify metadata input (Document Information Dictionary) (#1851) - Extend cmap compatibility to GBK_EUC_H/V (#1812) ### Bug Fixes (BUG) - Prevent infinite loop when no character follows after a comment (#1828) - get_contents does not return ContentStream (#1847) - Accept XYZ destination with zoom missing (default to zoom=0.0) (#1844) - Cope with 1 Bit images (#1815) ### Robustness (ROB) - Handle missing /Type entry in Page tree (#1845) ### Documentation (DOC) - Expand file size explanations (#1835) - Add comparison with pdfplumber (#1837) - Clarify that PyPDF2 is dead (#1827) - Add Hunter King as Contributor for #1806 ### Maintenance (MAINT) - Refactor internal Encryption class (#1821) - Add R parameter to generate_values (#1820) - Make encryption_key parameter of write_to_stream optional (#1819) - Prepare for adding AES encryption support (#1818) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.8.1...3.9.0) ## Version 3.8.1, 2023-04-23 ### Bug Fixes (BUG) - Convert color space before saving (#1802) ### Documentation (DOC) - PDF/A (#1807) - Use append instead of add_page - Document core mechanics of pypdf (#1783) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.8.0...3.8.1) ## Version 3.8.0, 2023-04-16 ### New Features (ENH) - Add transform method to Transformation class (#1765) - Cope with UC2 fonts in text_extraction (#1785) ### Robustness (ROB) - Invalid startxref pointing 1 char before (#1784) ### Maintenance (MAINT) - Mark code handling old parameters as deprecated (#1798) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.7.1...3.8.0) ## Version 3.7.1, 2023-04-09 ### Security (SEC) - Warn about PDF encryption security (#1755) ### Robustness (ROB) - Prevent loop in Cloning (#1770) - Capture UnicodeDecodeError at PdfReader.pdf_header (#1768) ### Documentation (DOC) - Add .readthedocs.yaml and bump docs dependencies using `tox -e deps` (#1750, #1752) ### Developer Experience (DEV) - Make make_changelog.py idempotent ### Maintenance (MAINT) - Move generation of file identifiers to a method (#1760) ### Testing (TST) - Add xmp test (#1775) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.7.0...3.7.1) ## Version 3.7.0, 2023-03-26 ### Security (SEC) - Use Python's secrets module instead of random module (#1748) ### New Features (ENH) - Add AnnotationBuilder.highlight text markup annotation (#1740) - Add AnnotationBuilder.popup (#1665) - Add AnnotationBuilder.polyline annotation support (#1726) - Add clone_from parameter in PdfWriter constructor (#1703) ### Bug Fixes (BUG) - 'DictionaryObject' object has no attribute 'indirect_reference' (#1729) ### Robustness (ROB) - Handle params NullObject in decode_stream_data (#1738) ### Documentation (DOC) - Project scope (#1743) ### Maintenance (MAINT) - Add AnnotationFlag (#1746) - Add LazyDict.__str__ (#1727) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.6.0...3.7.0) ## Version 3.6.0, 2023-03-18 ### New Features (ENH) - Extend PdfWriter.append() to PageObjects (#1704) - Support qualified names in update_page_form_field_values (#1695) ### Robustness (ROB) - Tolerate streams without length field (#1717) - Accept DictionaryObject in /D of NamedDestination (#1720) - Widths def in cmap calls IndirectObject (#1719) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.5.2...3.6.0) ## Version 3.5.2, 2023-03-12 ⚠️ We discovered that compress_content_stream has to be applied to a page of the PdfWriter. It may not be applied to a page of the PdfReader! ### Bug Fixes (BUG) - compress_content_stream not readable in Adobe Acrobat (#1698) - Pass logging parameters correctly in set_need_appearances_writer (#1697) - Write /Root/AcroForm in set_need_appearances_writer (#1639) ### Robustness (ROB) - Allow more whitespaces within linearized file (#1701) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.5.1...3.5.2) ## Version 3.5.1, 2023-03-05 ### Robustness (ROB) - Some attributes not copied in DictionaryObject._clone (#1635) - Allow merging multiple time pages with annots (#1624) ### Testing (TST) - Replace pytest.mark.external by enable_socket (#1657) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.5.0...3.5.1) ## Version 3.5.0, 2023-02-26 ### New Features (ENH) - Add reader.attachments public interface (#1611, #1661) - Add PdfWriter.remove_objects_from_page(page: PageObject, to_delete: ObjectDeletionFlag) (#1648) - Allow free-text annotation to have transparent border/background (#1664) ### Bug Fixes (BUG) - Allow decryption with empty password for AlgV5 (#1663) - Let PdfWriter.pages return PageObject after calling `clone_document_from_reader()` (#1613) - Invalid font pointed during merge_resources (#1641) ### Robustness (ROB) - Cope with invalid objects in IndirectObject.clone (#1637) - Improve tolerance to invalid Names/Dests (#1658) - Decode encoded values in get_fields (#1636) - Let PdfWriter.merge cope with missing "/Fields" (#1628) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.4.1...3.5.0) ## Version 3.4.1, 2023-02-12 ### Bug Fixes (BUG) - Switch from trimbox to cropbox when merging pages (#1622) - Text extraction not working with one glyph to char sequence (#1620) ### Robustness (ROB) - Fix 2 cases of "object has no attribute \'indirect_reference\'" (#1616) ### Testing (TST) - Add multiple retry on get_url for external PDF downloads (#1626) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.4.0...3.4.1) ## Version 3.4.0, 2023-02-05 NOTICE: pypdf changed the way it represents numbers parsed from PDF files. pypdf<3.4.0 represented numbers as Decimal, pypdf>=3.4.0 represents them as floats. Several other PDF libraries to this, as well as many PDF viewers. We hope to fix issues with too high precision like this and get a speed boost. In case your PDF documents rely on more than 18 decimals of precision you should check if it still works as expected. To clarify: This does not affect the text shown in PDF documents. It affects numbers, e.g. when graphics are drawn on the PDF or very exact positions are used. Typically, 5 decimals should be enough. ### New Features (ENH) - Enable merging forms with overlapping names (#1553) - Add 'over' parameter to merge_transformend_page & co (#1567) ### Bug Fixes (BUG) - Fix getter of the PageObject.rotation property with an indirect object (#1602) - Restore merge_transformed_page & co (#1567) - Replace decimal by float (#1563) ### Robustness (ROB) - PdfWriter.remove_images: /Contents might not be in page_ref (#1598) ### Developer Experience (DEV) - Introduce ruff (#1586, #1609) ### Maintenance (MAINT) - Remove decimal (#1608) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.3.0...3.4.0) ## Version 3.3.0, 2023-01-22 ### New Features (ENH) - Add page label support to PdfWriter (#1558) - Accept inline images with space before EI (#1552) - Add circle annotation support (#1556) - Add polygon annotation support (#1557) - Make merging pages produce a deterministic PDF (#1542, #1543) ### Bug Fixes (BUG) - Fix error in cmap extraction (#1544) - Remove erroneous assertion check (#1564) - Fix dictionary access of optional page label keys (#1562) ### Robustness (ROB) - Set ignore_eof=True for read_until_regex (#1521) ### Documentation (DOC) - Paper size (#1550) ### Developer Experience (DEV) - Fix broken combination of dependencies of docs.txt - Annotate tests appropriately (#1551) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.2.1...3.3.0) ## Version 3.2.1, 2023-01-08 ### Bug Fixes (BUG) - Accept hierarchical fields (#1529) ### Documentation (DOC) - Use google style docstrings (#1534) - Fix linked markdown documents (#1537) ### Developer Experience (DEV) - Update docs config (#1535) ## Version 3.2.0, 2022-12-31 ### Performance Improvement (PI) - Help the specializing adaptive interpreter (#1522) ### New Features (ENH) - Add support for page labels (#1519) ### Bug Fixes (BUG) - upgrade clone_document_root (#1520) [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.1.0...3.1.1) ## Version 3.1.0, 2022-12-23 Move PyPDF2 to pypdf (#1513). This now it's all lowercase, no number in the name. For installation and for import. PyPDF2 will no longer receive updates. The community should move back to its roots. If you were still using pyPdf or PyPDF2 < 2.0.0, I recommend reading the migration guide: https://pypdf.readthedocs.io/en/latest/user/migration-1-to-2.html pypdf==3.1.0 is only different from PyPDF2==3.0.0 in the package name. Replacing "PyPDF2" by "pypdf" should be enough if you migrate from `PyPDF2==3.0.0` to `pypdf==3.1.0`. [Full Changelog](https://github.com/py-pdf/pypdf/compare/3.0.0...3.1.0) ## Version 3.0.0, 2022-12-22 ### BREAKING CHANGES ⚠️ - Deprecate features with PyPDF2==3.0.0 (#1489) - Refactor Fit / Zoom parameters (#1437) ### New Features (ENH) - Add Cloning (#1371) - Allow int for indirect_reference in PdfWriter.get_object (#1490) ### Documentation (DOC) - How to read PDFs from S3 (#1509) - Make MyST parse all links as simple hyperlinks (#1506) - Changed 'latest' for 'stable' generated docs (#1495) - Adjust deprecation procedure (#1487) ### Maintenance (MAINT) - Use typing.IO for file streams (#1498) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.12.1...3.0.0) ## Version 2.12.1, 2022-12-10 ### Documentation (DOC) - Deduplicate extract_text docstring (#1485) - How to cite PyPDF2 (#1476) ### Maintenance (MAINT) Consistency changes: - indirect_ref/ido âž” indirect_reference, destâž” page_destination (#1467) - owner_pwd/user_pwd âž” owner_password/user_password (#1483) - position âžś page_number in Merger.merge (#1482) - indirect_ref âžś indirect_reference (#1484) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.12.0...2.12.1) ## Version 2.12.0, 2022-12-10 ### New Features (ENH) - Add support to extract gray scale images (#1460) - Add 'threads' property to PdfWriter (#1458) - Add 'open_destination' property to PdfWriter (#1431) - Make PdfReader.get_object accept integer arguments (#1459) ### Bug Fixes (BUG) - Scale PDF annotations (#1479) ### Robustness (ROB) - Padding issue with AES encryption (#1469) - Accept empty object as null objects (#1477) ### Documentation (DOC) - Add module documentation the PaperSize class (#1447) ### Maintenance (MAINT) - Use 'page_number' instead of 'pagenum' (#1365) - Add List of pages to PageRangeSpec (#1456) ### Testing (TST) - Cleanup temporary files (#1454) - Mark test_tounicode_is_identity as external (#1449) - Use Ubuntu 20.04 for running CI test suite (#1452) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.11.2...2.12.0) ## Version 2.11.2, 2022-11-20 ### New Features (ENH) - Add remove_from_tree (#1432) - Add AnnotationBuilder.rectangle (#1388) ### Bug Fixes (BUG) - JavaScript executed twice (#1439) - ToUnicode stores /Identity-H instead of stream (#1433) - Declare Pillow as optional dependency (#1392) ### Developer Experience (DEV) - Link 'Full Changelog' automatically - Modify read_string_from_stream to a benchmark (#1415) - Improve error reporting of read_object (#1412) - Test Python 3.11 (#1404) - Extend Flake8 ignore list (#1410) - Use correct pytest markers (#1407) - Move project configuration to pyproject.toml (#1382) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.11.1...2.11.2) ## Version 2.11.1, 2022-10-09 ### Bug Fixes (BUG) - td matrix (#1373) - Cope with cmap from #1322 (#1372) ### Robustness (ROB) - Cope with str returned from get_data in cmap (#1380) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.11.0...2.11.1) ## Version 2.11.0, 2022-09-25 ### New Features (ENH) - Addition of optional visitor-functions in extract_text() (#1252) - Add metadata.creation_date and modification_date (#1364) - Add PageObject.images attribute (#1330) ### Bug Fixes (BUG) - Lookup index in _xobj_to_image can be ByteStringObject (#1366) - 'IndexError: index out of range' when using extract_text (#1361) - Errors in transfer_rotation_to_content() (#1356) ### Robustness (ROB) - Ensure update_page_form_field_values does not fail if no fields (#1346) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.10.9...2.11.0) ## Version 2.10.9, 2022-09-18 ### New Features (ENH) - Add rotation property and transfer_rotate_to_content (#1348) ### Performance Improvements (PI) - Avoid string concatenation with large embedded base64-encoded images (#1350) ### Bug Fixes (BUG) - Format floats using their intrinsic decimal precision (#1267) ### Robustness (ROB) - Fix merge_page for pages without resources (#1349) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.10.8...2.10.9) ## Version 2.10.8, 2022-09-14 ### New Features (ENH) - Add PageObject.user_unit property (#1336) ### Robustness (ROB) - Improve NameObject reading/writing (#1345) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.10.7...2.10.8) ## Version 2.10.7, 2022-09-11 ### Bug Fixes (BUG) - Fix Error in transformations (#1341) - Decode #23 in NameObject (#1342) ### Testing (TST) - Use pytest.warns() for warnings, and .raises() for exceptions (#1325) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.10.6...2.10.7) ## Version 2.10.6, 2022-09-09 ### Robustness (ROB) - Fix infinite loop due to Invalid object (#1331) - Fix image extraction issue with superfluous whitespaces (#1327) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.10.5...2.10.6) ## Version 2.10.5, 2022-09-04 ### New Features (ENH) - Process XRefStm (#1297) - Auto-detect RTL for text extraction (#1309) ### Bug Fixes (BUG) - Avoid scaling cropbox twice (#1314) ### Robustness (ROB) - Fix offset correction in revised PDF (#1318) - Crop data of /U and /O in encryption dictionary to 48 bytes (#1317) - MultiLine bfrange in cmap (#1299) - Cope with 2 digit codes in bfchar (#1310) - Accept '/annn' charset as ASCII code (#1316) - Log errors during Float / NumberObject initialization (#1315) - Cope with corrupted entries in xref table (#1300) ### Documentation (DOC) - Migration guide (PyPDF2 1.x âž” 2.x) (#1324) - Creating a coverage report (#1319) - Fix AnnotationBuilder.free_text example (#1311) - Fix usage of page.scale by replacing it with page.scale_by (#1313) ### Maintenance (MAINT) - PdfReaderProtocol (#1303) - Throw PdfReadError if Trailer can't be read (#1298) - Remove catching OverflowException (#1302) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.10.4...2.10.5) ## Version 2.10.4, 2022-08-28 ### Robustness (ROB) - Fix errors/warnings on no /Resources within extract_text (#1276) - Add required line separators in ContentStream ArrayObjects (#1281) ### Maintenance (MAINT) - Use NameObject idempotency (#1290) ### Testing (TST) - Rectangle deletion (#1289) - Add workflow tests (#1287) - Remove files after tests ran (#1286) ### Packaging (PKG) - Add minimum version for typing_extensions requirement (#1277) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.10.3...2.10.4) ## Version 2.10.3, 2022-08-21 ### Robustness (ROB) - Decrypt returns empty bytestring (#1258) ### Developer Experience (DEV) - Modify CI to better verify built package contents (#1244) ### Maintenance (MAINT) - Remove 'mine' as PdfMerger always creates the stream (#1261) - Let PdfMerger._create_stream raise NotImplemented (#1251) - password param of _security._alg32(...) is only a string, not bytes (#1259) - Remove unreachable code in read_block_backwards (#1250) and sign function in _extract_text (#1262) ### Testing (TST) - Delete annotations (#1263) - Close PdfMerger in tests (#1260) - PdfReader.xmp_metadata workflow (#1257) - Various PdfWriter (Layout, Bookmark deprecation) (#1249) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.10.2...2.10.3) ## Version 2.10.2, 2022-08-15 BUG: Add PyPDF2.generic to PyPI distribution ## Version 2.10.1, 2022-08-15 ### Bug Fixes (BUG) - TreeObject.remove_child had a non-PdfObject assignment for Count (#1233, #1234) - Fix stream truncated prematurely (#1223) ### Documentation (DOC) - Fix docstring formatting (#1228) ### Maintenance (MAINT) - Split generic.py (#1229) ### Testing (TST) - Decrypt AlgV4 with owner password (#1239) - AlgV5.generate_values (#1238) - TreeObject.remove_child / empty_tree (#1235, #1236) - create_string_object (#1232) - Free-Text annotations (#1231) - generic._base (#1230) - Strict get fonts (#1226) - Increase PdfReader coverage (#1219, #1225) - Increase PdfWriter coverage (#1237) - 100% coverage for utils.py (#1217) - PdfWriter exception non-binary stream (#1218) - Don't check coverage for deprecated code (#1216) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.10.0...2.10.1) ## Version 2.10.0, 2022-08-07 ### New Features (ENH) - "with" support for PdfMerger and PdfWriter (#1193) - Add AnnotationBuilder.text(...) to build text annotations (#1202) ### Bug Fixes (BUG) - Allow IndirectObjects as stream filters (#1211) ### Documentation (DOC) - Font scrambling - Page vs Content scaling (#1208) - Example for orientation parameter of extract_text (#1206) - Fix AnnotationBuilder parameter formatting (#1204) ### Developer Experience (DEV) - Add flake8-print (#1203) ### Maintenance (MAINT) - Introduce WrongPasswordError / FileNotDecryptedError / EmptyFileError (#1201) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.9.0...2.10.0) ## Version 2.9.0, 2022-07-31 ### New Features (ENH) - Add ability to add hex encoded colors to outline items (#1186) - Add support for pathlib.Path in PdfMerger.merge (#1190) - Add link annotation (#1189) - Add capability to filter text extraction by orientation (#1175) ### Bug Fixes (BUG) - Named Dest in PDF1.1 (#1174) - Incomplete Graphic State save/restore (#1172) ### Documentation (DOC) - Update changelog url in package metadata (#1180) - Mention camelot for table extraction (#1179) - Mention pyHanko for signing PDF documents (#1178) - Weow have CMAP support since a while (#1177) ### Maintenance (MAINT) - Consistent usage of warnings / log messages (#1164) - Consistent terminology for outline items (#1156) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.8.1...2.9.0) ## Version 2.8.1, 2022-07-25 ### Bug Fixes (BUG) - u_hash in AlgV4.compute_key (#1170) ### Robustness (ROB) - Fix loading of file from #134 (#1167) - Cope with empty DecodeParams (#1165) ### Documentation (DOC) - Typo in merger deprecation warning message (#1166) ### Maintenance (MAINT) - Package updates; solve mypy strict remarks (#1163) ### Testing (TST) - Add test from #325 (#1169) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.8.0...2.8.1) ## Version 2.8.0, 2022-07-24 ### New Features (ENH) - Add writer.add_annotation, page.annotations, and generic.AnnotationBuilder (#1120) ### Bug Fixes (BUG) - Set /AS for /Btn form fields in writer (#1161) - Ignore if /Perms verify failed (#1157) ### Robustness (ROB) - Cope with utf16 character for space calculation (#1155) - Cope with null params for FitH / FitV destination (#1152) - Handle outlines without valid destination (#1076) ### Developer Experience (DEV) - Introduce _utils.logger_warning (#1148) ### Maintenance (MAINT) - Break up parse_to_unicode (#1162) - Add diagnostic output to exception in read_from_stream (#1159) - Reduce PdfReader.read complexity (#1151) ### Testing (TST) - Add workflow tests found by arc testing (#1154) - Decrypt file which is not encrypted (#1149) - Test CryptRC4 encryption class; test image extraction filters (#1147) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.7.0...2.8.0) ## Version 2.7.0, 2022-07-21 ### New Features (ENH) - Add `outline_count` property (#1129) ### Bug Fixes (BUG) - Make reader.get_fields also return dropdowns with options (#1114) - Add deprecated EncodedStreamObject functions back until PyPDF2==3.0.0 (#1139) ### Robustness (ROB) - Cope with missing /W entry (#1136) - Cope with invalid parent xref (#1133) ### Documentation (DOC) - Contributors file (#1132) - Fix type in signature of PdfWriter.add_uri (#1131) ### Developer Experience (DEV) - Add .git-blame-ignore-revs (#1141) ### Code Style (STY) - Fixing typos (#1137) - Reuse code via get_outlines_property in tests (#1130) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.6.0...2.7.0) ## Version 2.6.0, 2022-07-17 ### New Features (ENH) - Add color and font_format to PdfReader.outlines[i] (#1104) - Extract Text Enhancement (whitespaces) (#1084) ### Bug Fixes (BUG) - Use `build_destination` for named destination outlines (#1128) - Avoid a crash when a ToUnicode CMap has an empty dstString in beginbfchar (#1118) - Prevent deduplication of PageObject (#1105) - None-check in DictionaryObject.read_from_stream (#1113) - Avoid IndexError in _cmap.parse_to_unicode (#1110) ### Documentation (DOC) - Explanation for git submodule - Watermark and stamp (#1095) ### Maintenance (MAINT) - Text extraction improvements (#1126) - Destination.color returns ArrayObject instead of tuple as fallback (#1119) - Use add_bookmark_destination in add_bookmark (#1100) - Use add_bookmark_destination in add_bookmark_dict (#1099) ### Testing (TST) - Add test for arab text (#1127) - Add xfail for decryption fail (#1125) - Add xfail test for IndexError when extracting text (#1124) - Add MCVE showing outline title issue (#1123) ### Code Style (STY) - Use IntFlag for permissions_flag / update_page_form_field_values (#1094) - Simplify code (#1101) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.5.0...2.6.0) ## Version 2.5.0, 2022-07-10 ### New Features (ENH) - Add support for indexed color spaces / BitsPerComponent for decoding PNGs (#1067) - Add PageObject._get_fonts (#1083) ### Performance Improvements (PI) - Use iterative DFS in PdfWriter._sweep_indirect_references (#1072) ### Bug Fixes (BUG) - Let Page.scale also scale the crop-/trim-/bleed-/artbox (#1066) - Column default for CCITTFaxDecode (#1079) ### Robustness (ROB) - Guard against None-value in _get_outlines (#1060) ### Documentation (DOC) - Stamps and watermarks (#1082) - OCR vs PDF text extraction (#1081) - Python Version support - Formatting of CHANGELOG ### Developer Experience (DEV) - Cache downloaded files (#1070) - Speed-up for CI (#1069) ### Maintenance (MAINT) - Set page.rotate(angle: int) (#1092) - Issue #416 was fixed by #1015 (#1078) ### Testing (TST) - Image extraction (#1080) - Image extraction (#1077) ### Code Style (STY) - Apply black - Typo in Changelog [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.4.2...2.5.0) ## Version 2.4.2, 2022-07-05 ### New Features (ENH) - Add PdfReader.xfa attribute (#1026) ### Bug Fixes (BUG) - Wrong page inserted when PdfMerger.merge is done (#1063) - Resolve IndirectObject when it refers to a free entry (#1054) ### Developer Experience (DEV) - Added {posargs} to tox.ini (#1055) ### Maintenance (MAINT) - Remove PyPDF2._utils.bytes_type (#1053) ### Testing (TST) - Scale page (indirect rect object) (#1057) - Simplify pathlib PdfReader test (#1056) - IndexError of VirtualList (#1052) - Invalid XML in xmp information (#1051) - No pycryptodome (#1050) - Increase test coverage (#1045) ### Code Style (STY) - DOC of compress_content_streams (#1061) - Minimize diff for #879 (#1049) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.4.1...2.4.2) ## Version 2.4.1, 2022-06-30 ### New Features (ENH) - Add writer.pdf_header property (getter and setter) (#1038) ### Performance Improvements (PI) - Remove b_ call in FloatObject.write_to_stream (#1044) - Check duplicate objects in writer._sweep_indirect_references (#207) ### Documentation (DOC) - How to surppress exceptions/warnings/log messages (#1037) - Remove hyphen from lossless (#1041) - Compression of content streams (#1040) - Fix inconsistent variable names in add-watermark.md (#1039) - File size reduction - Add CHANGELOG to the rendered docs (#1023) ### Maintenance (MAINT) - Handle XML error when reading XmpInformation (#1030) - Deduplicate Code / add mutmut config (#1022) ### Code Style (STY) - Use unnecessary one-line function / class attribute (#1043) - Docstring formatting (#1033) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.4.0...2.4.1) ## Version 2.4.0, 2022-06-26 ### New Features (ENH): - Support R6 decrypting (#1015) - Add PdfReader.pdf_header (#1013) ### Performance Improvements (PI): - Remove ord_ calls (#1014) ### Bug Fixes (BUG): - Fix missing page for bookmark (#1016) ### Robustness (ROB): - Deal with invalid Destinations (#1028) ### Documentation (DOC): - get_form_text_fields does not extract dropdown data (#1029) - Adjust PdfWriter.add_uri docstring - Mention crypto extra_requires for installation (#1017) ### Developer Experience (DEV): - Use /n line endings everywhere (#1027) - Adjust string formatting to be able to use mutmut (#1020) - Update Bug report template [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.3.1...2.4.0) ## Version 2.3.1, 2022-06-19 BUG: Forgot to add the internal `_codecs` subpackage. [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.3.0...2.3.1) ## Version 2.3.0, 2022-06-19 The highlight of this release is improved support for file encryption (AES-128 and AES-256, R5 only). See #749 for the amazing work of @exiledkingcc 🎊 Thank you 🤗 ### Deprecations (DEP) - Rename names to be PEP8-compliant (#967) - `PdfWriter.get_page`: the pageNumber parameter is renamed to page_number - `PyPDF2.filters`: * For all classes, a parameter rename: decodeParms âž” decode_parms * decodeStreamData âž” decode_stream_data - `PyPDF2.xmp`: * XmpInformation.rdfRoot âž” XmpInformation.rdf_root * XmpInformation.xmp_createDate âž” XmpInformation.xmp_create_date * XmpInformation.xmp_creatorTool âž” XmpInformation.xmp_creator_tool * XmpInformation.xmp_metadataDate âž” XmpInformation.xmp_metadata_date * XmpInformation.xmp_modifyDate âž” XmpInformation.xmp_modify_date * XmpInformation.xmpMetadata âž” XmpInformation.xmp_metadata * XmpInformation.xmpmm_documentId âž” XmpInformation.xmpmm_document_id * XmpInformation.xmpmm_instanceId âž” XmpInformation.xmpmm_instance_id - `PyPDF2.generic`: * readHexStringFromStream âž” read_hex_string_from_stream * initializeFromDictionary âž” initialize_from_dictionary * createStringObject âž” create_string_object * TreeObject.hasChildren âž” TreeObject.has_children * TreeObject.emptyTree âž” TreeObject.empty_tree ### New Features (ENH) - Add decrypt support for V5 and AES-128, AES-256 (R5 only) (#749) ### Robustness (ROB) - Fix corrupted (wrongly) linear PDF (#1008) ### Maintenance (MAINT) - Move PDF_Samples folder into resources - Fix typos (#1007) ### Testing (TST) - Improve encryption/decryption test (#1009) - Add merger test cases with real PDFs (#1006) - Add mutmut config ### Code Style (STY) - Put pure data mappings in separate files (#1005) - Make encryption module private, apply pre-commit (#1010) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.2.1...2.3.0) ## Version 2.2.1, 2022-06-17 ### Performance Improvements (PI) - Remove b_ calls (#992, #986) - Apply improvements to _utils suggested by perflint (#993) ### Robustness (ROB) - utf-16-be codec can't decode (...) (#995) ### Documentation (DOC) - Remove reference to Scripts (#987) ### Developer Experience (DEV) - Fix type annotations for add_bookmarks (#1000) ### Testing (TST) - Add test for PdfMerger (#1001) - Add tests for XMP information (#996) - reader.get_fields / zlib issue / LZW decode issue (#1004) - reader.get_fields with report generation (#1002) - Improve test coverage by extracting texts (#998) ### Code Style (STY) - Apply fixes suggested by pylint (#999) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.2.0...2.2.1) ## Version 2.2.0, 2022-06-13 The 2.2.0 release improves text extraction again via (#969): * Improvements around /Encoding / /ToUnicode * Extraction of CMaps improved * Fallback for font def missing * Support for /Identity-H and /Identity-V: utf-16-be * Support for /GB-EUC-H / /GB-EUC-V / GBp/c-EUC-H / /GBpc-EUC-V (beta release for evaluation) * Arabic (for evaluation) * Whitespace extraction improvements Those changes should mainly improve the text extraction for non-ASCII alphabets, e.g. Russian / Chinese / Japanese / Korean / Arabic. [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.1.1...2.2.0) ## Version 2.1.1, 2022-06-12 ### New Features (ENH) - Add support for pathlib as input for PdfReader (#979) ### Performance Improvements (PI) - Optimize read_next_end_line (#646) ### Bug Fixes (BUG) - Adobe Acrobat 'Would you like to save this file?' (#970) ### Documentation (DOC) - Notes on annotations (#982) - Who uses PyPDF2 - intendet \xe2\x9e\x94 in robustness page (#958) ### Maintenance (MAINT) - pre-commit / requirements.txt updates (#977) - Mark read_next_end_line as deprecated (#965) - Export `PageObject` in PyPDF2 root (#960) ### Testing (TST) - Add MCVE of issue #416 (#980) - FlateDecode.decode decodeParms (#964) - Xmp module (#962) - utils.paeth_predictor (#959) ### Code Style (STY) - Use more tuples and list/dict comprehensions (#976) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.1.0...2.1.1) ## Version 2.1.0, 2022-06-06 The highlight of the 2.1.0 release is the most massive improvement to the text extraction capabilities of PyPDF2 since 2016 🥳🎊 A very big thank you goes to [pubpub-zz](https://github.com/pubpub-zz) who took a lot of time and knowledge about the PDF format to finally get those improvements into PyPDF2. Thank you 🤗💚 In case the new function causes any issues, you can use `_extract_text_old` for the old functionality. Please also open a bug ticket in that case. There were several people who have attempted to bring similar improvements to PyPDF2. All of those were valuable. The main reason why they didn't get merged is the big amount of open PRs / issues. pubpub-zz was the most comprehensive PR which also incorporated the latest changes of PyPDF2 2.0.0. Thank you to [VictorCarlquist](https://github.com/VictorCarlquist) for #858 and [asabramo](https://github.com/asabramo) for #464 🤗 ### New Features (ENH) - Massive text extraction improvement (#924). Closed many open issues: - Exceptions / missing spaces in extract_text() method (#17) đź•ş - Whitespace issues in extract_text() (#42) đź’ - pypdf2 reads the hifenated words in a new line (#246) - PyPDF2 failing to read unicode character (#37) - Unable to read bullets (#230) - ExtractText yields nothing for apparently good PDF (#168) 🎉 - Encoding issue in extract_text() (#235) - extractText() doesn't work on Chinese PDF (#252) - encoding error (#260) - Trouble with apostophes in names in text "O'Doul" (#384) - extract_text works for some PDF files, but not the others (#437) - Euro sign not being recognized by extractText (#443) - Failed extracting text from French texts (#524) - extract_text doesn't extract ligatures correctly (#598) - reading spanish text - mark convert issue (#635) - Read PDF changed from text to random symbols (#654) - .extractText() reads / as 1. (#789) - Update glyphlist (#947) - inspired by #464 - Allow adding PageRange objects (#948) ### Bug Fixes (BUG) - Delete .python-version file (#944) - Compare StreamObject.decoded_self with None (#931) ### Robustness (ROB) - Fix some conversion errors on non conform PDF (#932) ### Documentation (DOC) - Elaborate on PDF text extraction difficulties (#939) - Add logo (#942) - rotate vs Transformation().rotate (#937) - Example how to use PyPDF2 with AWS S3 (#938) - How to deprecate (#930) - Fix typos on robustness page (#935) - Remove scripts (pdfcat) from docs (#934) ### Developer Experience (DEV) - Ignore .python-version file - Mark deprecated code with no-cover (#943) - Automatically create Github releases from tags (#870) ### Testing (TST) - Text extraction for non-latin alphabets (#954) - Ignore PdfReadWarning in benchmark (#949) - writer.remove_text (#946) - Add test for Tree and _security (#945) ### Code Style (STY) - black, isort, Flake8, splitting buildCharMap (#950) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/2.0.0...2.1.0) ## Version 2.0.0, 2022-06-01 The 2.0.0 release of PyPDF2 includes three core changes: 1. Dropping support for Python 3.5 and older. 2. Introducing type annotations. 3. Interface changes, mostly to have PEP8-compliant names We introduced a [deprecation process](https://github.com/py-pdf/PyPDF2/pull/930) that hopefully helps users to avoid unexpected breaking changes. ### Breaking Changes (DEP) - PyPDF2 2.0 requires Python 3.6+. Python 2.7 and 3.5 support were dropped. - PdfFileReader: The "warndest" parameter was removed - PdfFileReader and PdfFileMerger no longer have the `overwriteWarnings` parameter. The new behavior is `overwriteWarnings=False`. - merger: OutlinesObject was removed without replacement. - merger.py âž” _merger.py: You must import PdfFileMerger from PyPDF2 directly. - utils: * `ConvertFunctionsToVirtualList` was removed * `formatWarning` was removed * `isInt(obj)`: Use `instance(obj, int)` instead * `u_(s)`: Use `s` directly * `chr_(c)`: Use `chr(c)` instead * `barray(b)`: Use `bytearray(b)` instead * `isBytes(b)`: Use `instance(b, type(bytes()))` instead * `xrange_fn`: Use `range` instead * `string_type`: Use `str` instead * `isString(s)`: Use `instance(s, str)` instead * `_basestring`: Use `str` instead * All Exceptions are now in `PyPDF2.errors`: - PageSizeNotDefinedError - PdfReadError - PdfReadWarning - PyPdfError - `PyPDF2.pdf` (the `pdf` module) no longer exists. The contents were moved with the library. You should most likely import directly from `PyPDF2` instead. The `RectangleObject` is in `PyPDF2.generic`. - The `Resources`, `Scripts`, and `Tests` will no longer be part of the distribution files on PyPI. This should have little to no impact on most people. The `Tests` are renamed to `tests`, the `Resources` are renamed to `resources`. Both are still in the git repository. The `Scripts` are now in [cpdf](https://github.com/py-pdf/cpdf). `Sample_Code` was moved to the `docs`. For a full list of deprecated functions, please see the changelog of version 1.28.0. ### New Features (ENH) - Improve space setting for text extraction (#922) - Allow setting the decryption password in `PdfReader.__init__` (#920) - Add Page.add_transformation (#883) ### Bug Fixes (BUG) - Fix error adding transformation to page without /Contents (#908) ### Robustness (ROB) - Cope with invalid length in streams (#861) ### Documentation (DOC) - Fix style of 1.25 and 1.27 patch notes (#927) - Transformation (#907) ### Developer Experience (DEV) - Create flake8 config file (#916) - Use relative imports (#875) ### Maintenance (MAINT) - Use Python 3.6 language features (#849) - Add wrapper function for PendingDeprecationWarnings (#928) - Use new PEP8 compliant names (#884) - Explicitly represent transformation matrix (#878) - Inline PAGE_RANGE_HELP string (#874) - Remove unnecessary generics imports (#873) - Remove star imports (#865) - merger.py âž” _merger.py (#864) - Type annotations for all functions/methods (#854) - Add initial type support with mypy (#853) ### Testing (TST) - Regression test for xmp_metadata converter (#923) - Checkout submodule sample-files for benchmark - Add text extracting performance benchmark - Use new PyPDF2 API in benchmark (#902) - Make test suite fail for uncaught warnings (#892) - Remove -OO testrun from CI (#901) - Improve tests for convert_to_int (#899) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/1.28.4...2.0.0) ## PyPDF2 1.X See [CHANGELOG PyPDF2 1.X](changelog-v1.md) pypdf-6.1.2/CONTRIBUTING.md000066400000000000000000000025271507516550200151070ustar00rootroot00000000000000Please check the [documentation page dedicated to development](https://pypdf.readthedocs.io/en/stable/dev/intro.html). ## Creating issues / tickets Please go here: https://github.com/py-pdf/pypdf/issues Typically you should not send e-mails. E-mails might only reach one person and it could go into spam or that person might be busy. Please create issues on GitHub instead. Please use the templates provided. Keep in mind that although PDF has an official specification, there are tons of variations which might require special handling. Thus, please always provide a reproducing example file for us to work with. Otherwise, we have to guess possible issues, leading to unnecessary overhead - especially since most of the contributions happen during our free time. If you already know a fix, consider opening a pull request after reporting the issue to make life easier for everyone. ## Creating Pull Requests We appreciate if people make PRs, but please be aware that pypdf is used by many people. That means: * We rarely make breaking changes and have a [deprecation process](https://pypdf.readthedocs.io/en/latest/dev/deprecations.html). * New features, especially adding to the public interface, typically need to be discussed first. Before you make bigger changes, open an issue to make the suggestion. Note which interface changes you want to make. pypdf-6.1.2/CONTRIBUTORS.md000066400000000000000000000114071507516550200151320ustar00rootroot00000000000000# Contributors pypdf had a lot of contributors since it started as pyPdf in 2005. We are a free software project without any company affiliation. We cannot pay contributors, but we do value their contributions. A lot of time, effort, and expertise went into this project. With this list, we recognize these awesome people 🤗 The list is definitely not complete. You can find more contributors via the git history and [GitHub's 'Contributors' feature](https://github.com/py-pdf/pypdf/graphs/contributors). ## Contributors to the pypdf (formerly pyPdf / PyPDF2) project * [abyesilyurt](https://github.com/abyesilyurt) * [ArkieCoder](https://github.com/ArkieCoder) * [Clauss, Christian](https://github.com/cclauss) * [DL6ER](https://github.com/DL6ER) * [Duy, Phan Thanh](https://github.com/zuypt) * [ediamondscience](https://github.com/ediamondscience) * [Ermeson, Felipe](https://github.com/FelipeErmeson) * [Freitag, François](https://github.com/francoisfreitag) * [Gagnon, William G.](https://github.com/williamgagnon) * [GĂłrny, MichaĹ‚](https://github.com/mgorny) * [Grillo, Miguel](https://github.com/Ineffable22) * [Gutteridge, David H.](https://github.com/dhgutteridge) * [Hale, Joseph](https://github.com/thehale) * [harshhes](https://github.com/harshhes) * [Jackowitz, Noah](https://github.com/hackowitz-af) | [LinkedIn](https://www.linkedin.com/in/noah-jackowitz/) * [JianzhengLuo](https://github.com/JianzhengLuo) * [Karvonen, Harry](https://github.com/Hatell/) * [King, Hunter](https://github.com/neversphere) * [Kotler, Mitchell](https://github.com/mitchelljkotler) * [KourFrost](https://github.com/KourFrost) * [Lightup1](https://github.com/Lightup1) * [Majumder, Jonah](https://github.com/jonahmajumder) * [Manini, Lorenzo](https://github.com/lorenzomanini) * [maxbeer99](https://github.com/maxbeer99) * [McNeil, Karen](https://github.com/karenlmcneil): Arabic Language Support * [MĂ©rino, Antoine](https://github.com/Merinorus) * [Murphy, Kevin](https://github.com/kmurphy4) * [nalin-udhaar](https://github.com/nalin-udhaar) * [Paramonov, Alexey](https://github.com/alexey-v-paramonov) * [Paternault, Louis](https://framagit.org/spalax) * [Perrensen, Olsen](https://github.com/olsonperrensen) * [pilotandy](https://github.com/pilotandy) * [Pinheiro, Arthur](https://github.com/xilopaint) * [pmiller66](https://github.com/pmiller66) * [Poddar, Arka](https://github.com/postmeback) * [programmarchy](https://github.com/programmarchy) * [pubpub-zz](https://github.com/pubpub-zz): involved in community development * [Ramos, Leodanis Pozo](https://github.com/lpozo) * [RitchieP](https://github.com/RitchieP) | [LinkedIn](https://www.linkedin.com/in/ritchie-p-892b31115/) | [StackOverflow](https://stackoverflow.com/users/13328625/casual-r?tab=profile) * [robbiebusinessacc](https://github.com/robbiebusinessacc) * [Roder, Thomas](https://github.com/MrTomRod) * [Rogmann, Sascha](https://github.com/srogmann) * [Röthenbacher, Thomas](https://github.com/troethe) * [shartzog](https://github.com/shartzog) * [stefan6419846](https://github.com/stefan6419846): Maintainer of pypdf since January 2025 * [sietzeberends](https://github.com/sietzeberends) * [Stober, Marc](https://github.com/marcstober) * [StĂĽber, Timo](https://github.com/omit66) * [Thoma, Martin](https://github.com/MartinThoma): Maintainer of pypdf from April 2022 to January 2025. I hope to build a great community with many awesome contributors. [LinkedIn](https://www.linkedin.com/in/martin-thoma/) | [StackOverflow](https://stackoverflow.com/users/562769/martin-thoma) | [Blog](https://martin-thoma.com/) * [Thomas, Reuben](https://github.com/rrthomas) * [Tobeabellwether](https://github.com/Tobeabellwether) * [WevertonGomes](https://github.com/WevertonGomesCosta) * [Wilson, Huon](https://github.com/huonw) * ztravis ## Adding a new contributor Contributors are: * Anybody who has a commit in `main` - no matter how small or how many. Also if it's via *co-authored-by*. * People who opened helpful issues: 1. Bugs: with complete MCVE 2. Well-described feature requests 3. Potentially some more. The maintainers of pypdf have the last call on that one. * Community work: This is exceptional. If the maintainers of pypdf see people being super helpful in answering issues / discussions or being very active on Stackoverflow, we also consider them being contributors to pypdf. Contributors can add themselves or ask via an GitHub Issue to be added. Please use the following format: ``` * Last name, First name: 140-characters of text; links to LinkedIn / GitHub / other profiles and personal pages are ok ``` OR ``` * GitHub Username: 140-characters of text; links to LinkedIn / GitHub / other profiles and personal pages are ok ``` and add the entry in the alphabetical order. The 140 characters are everything visible after the `Name:`. Please don't use images. pypdf-6.1.2/LICENSE000066400000000000000000000031051507516550200136540ustar00rootroot00000000000000Copyright (c) 2006-2008, Mathieu Fenniak Some contributions copyright (c) 2007, Ashish Kulkarni Some contributions copyright (c) 2014, Steve Witham All rights reserved. Redistribution and use in source and binary forms, with or without modification, are permitted provided that the following conditions are met: * Redistributions of source code must retain the above copyright notice, this list of conditions and the following disclaimer. * Redistributions in binary form must reproduce the above copyright notice, this list of conditions and the following disclaimer in the documentation and/or other materials provided with the distribution. * The name of the author may not be used to endorse or promote products derived from this software without specific prior written permission. THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. pypdf-6.1.2/Makefile000066400000000000000000000014061507516550200143110ustar00rootroot00000000000000maint: pre-commit autoupdate pip-compile -U requirements/ci.in pip-compile -U requirements/dev.in pip-compile -U requirements/docs.in release: python make_release.py git commit -eF RELEASE_COMMIT_MSG.md clean: python -m pip install pyclean pyclean . rm -rf tests/__pycache__ pypdf/__pycache__ htmlcov docs/_build dist pypdf.egg-info .pytest_cache .mypy_cache .benchmarks test: pytest tests --cov --cov-report term-missing -vv --cov-report html --durations=3 --timeout=60 pypdf testtype: pytest tests --cov --cov-report term-missing -vv --cov-report html --durations=3 --timeout=30 --typeguard-packages=pypdf benchmark: pytest tests/bench.py mypy: mypy pypdf --ignore-missing-imports --check-untyped --strict ruff: ruff check pypdf tests make_release.py pypdf-6.1.2/README.md000066400000000000000000000113721507516550200141330ustar00rootroot00000000000000[![PyPI version](https://badge.fury.io/py/pypdf.svg)](https://badge.fury.io/py/pypdf) [![Python Support](https://img.shields.io/pypi/pyversions/pypdf.svg)](https://pypi.org/project/pypdf/) [![](https://img.shields.io/badge/-documentation-green)](https://pypdf.readthedocs.io/en/stable/) [![GitHub last commit](https://img.shields.io/github/last-commit/py-pdf/pypdf)](https://github.com/py-pdf/pypdf) [![codecov](https://codecov.io/gh/py-pdf/pypdf/branch/main/graph/badge.svg?token=id42cGNZ5Z)](https://codecov.io/gh/py-pdf/pypdf) # pypdf pypdf is a free and open-source pure-python PDF library capable of splitting, [merging](https://pypdf.readthedocs.io/en/stable/user/merging-pdfs.html), [cropping, and transforming](https://pypdf.readthedocs.io/en/stable/user/cropping-and-transforming.html) the pages of PDF files. It can also add custom data, viewing options, and [passwords](https://pypdf.readthedocs.io/en/stable/user/encryption-decryption.html) to PDF files. pypdf can [retrieve text](https://pypdf.readthedocs.io/en/stable/user/extract-text.html) and [metadata](https://pypdf.readthedocs.io/en/stable/user/metadata.html) from PDFs as well. See [pdfly](https://github.com/py-pdf/pdfly) for a CLI application that uses pypdf to interact with PDFs. ## Installation Install pypdf using pip: ``` pip install pypdf ``` For using pypdf with AES encryption or decryption, install extra dependencies: ``` pip install pypdf[crypto] ``` > **NOTE**: `pypdf` 3.1.0 and above include significant improvements compared to > previous versions. Please refer to [the migration > guide](https://pypdf.readthedocs.io/en/latest/user/migration-1-to-2.html) for > more information. ## Usage ```python from pypdf import PdfReader reader = PdfReader("example.pdf") number_of_pages = len(reader.pages) page = reader.pages[0] text = page.extract_text() ``` pypdf can do a lot more, e.g. splitting, merging, reading and creating annotations, decrypting and encrypting. Check out the [documentation](https://pypdf.readthedocs.io/en/stable/) for additional usage examples! For questions and answers, visit [StackOverflow](https://stackoverflow.com/questions/tagged/pypdf) (tagged with [pypdf](https://stackoverflow.com/questions/tagged/pypdf)). ## Contributions Maintaining pypdf is a collaborative effort. You can support the project by writing documentation, helping to narrow down issues, and submitting code. See the [CONTRIBUTING.md](https://github.com/py-pdf/pypdf/blob/main/CONTRIBUTING.md) file for more information. ### Q&A The experience pypdf users have covers the whole range from beginner to expert. You can contribute to the pypdf community by answering questions on [StackOverflow](https://stackoverflow.com/questions/tagged/pypdf), helping in [discussions](https://github.com/py-pdf/pypdf/discussions), and asking users who report issues for [MCVE](https://stackoverflow.com/help/minimal-reproducible-example)'s (Code + example PDF!). ### Issues A good bug ticket includes a MCVE - a minimal complete verifiable example. For pypdf, this means that you must upload a PDF that causes the bug to occur as well as the code you're executing with all of the output. Use `print(pypdf.__version__)` to tell us which version you're using. ### Code All code contributions are welcome, but smaller ones have a better chance to get included in a timely manner. Adding unit tests for new features or test cases for bugs you've fixed help us to ensure that the Pull Request (PR) is fine. pypdf includes a test suite which can be executed with `pytest`: ```bash $ pytest ===================== test session starts ===================== platform linux -- Python 3.6.15, pytest-7.0.1, pluggy-1.0.0 rootdir: /home/moose/GitHub/Martin/pypdf plugins: cov-3.0.0 collected 233 items tests/test_basic_features.py .. [ 0%] tests/test_constants.py . [ 1%] tests/test_filters.py .................x..... [ 11%] tests/test_generic.py ................................. [ 25%] ............. [ 30%] tests/test_javascript.py .. [ 31%] tests/test_merger.py . [ 32%] tests/test_page.py ......................... [ 42%] tests/test_pagerange.py ................ [ 49%] tests/test_papersizes.py .................. [ 57%] tests/test_reader.py .................................. [ 72%] ............... [ 78%] tests/test_utils.py .................... [ 87%] tests/test_workflows.py .......... [ 91%] tests/test_writer.py ................. [ 98%] tests/test_xmp.py ... [100%] ========== 232 passed, 1 xfailed, 1 warning in 4.52s ========== ``` pypdf-6.1.2/docs/000077500000000000000000000000001507516550200136005ustar00rootroot00000000000000pypdf-6.1.2/docs/Makefile000066400000000000000000000011721507516550200152410ustar00rootroot00000000000000# Minimal makefile for Sphinx documentation # # You can set these variables from the command line, and also # from the environment for the first two. SPHINXOPTS ?= SPHINXBUILD ?= sphinx-build SOURCEDIR = . 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It defines a starting point: ```text 1 beginbfchar <1B> ``` That means that `1B` (Hex for 27) maps to the Unicode character [`FB00`](https://unicode-table.com/en/FB00/) - the ligature ff (two lowercase f's). The two numbers in `begincodespacerange` mean that it starts with an offset of 0 (hence from `1B âžś FB00`) up to an offset of FF (dec: 255), hence 1B+FF = 282 âžś [FBFF](https://www.compart.com/de/unicode/U+FBFF). Within the text stream, there is ```text (The)-342(mis\034ts.) ``` `\034 ` is octal for the decimal value 28. pypdf-6.1.2/docs/dev/deprecations.md000066400000000000000000000036431507516550200173660ustar00rootroot00000000000000# The Deprecation Process pypdf strives to be an excellent library for its current users and for new ones. We are careful with introducing potentially breaking changes, but we will do them if they provide value for the community in the long run. We hope and think that deprecations will not happen frequently. If they do, users can rely on the following procedure. ## Semantic Versioning pypdf uses [semantic versioning](https://semver.org/). If you want to avoid breaking changes, please use dependency pinning (also known as version pinning). In Python, this is done by specifying the exact version you want to use in a `requirements.txt` file. A tool that can support you is `pip-compile` from [`pip-tools`](https://pypi.org/project/pip-tools/). If you are using [Poetry](https://pypi.org/project/poetry/) it is done with the `poetry.lock` file. ## How pypdf deprecates features Assume the current version of pypdf is `x.y.z`. After a discussion (e.g., via GitHub issues), we decided to remove a class / function / method. This is how we do it: 1. `x.y.(z+1)`: Add a DeprecationWarning. If there is a replacement, the replacement is also introduced and the warning informs about the change and when it will happen. The docs let users know about the deprecation and when it will happen and the new function. The CHANGELOG informs about it. 2. `(x+1).0.0`: Remove / change the code in the breaking way by replacing DeprecationWarnings by DeprecationErrors. We do this to help people who didn't look at the warnings before. The CHANGELOG informs about it. 3. `(x+2).0.0`: The DeprecationErrors are removed. This means the users have three warnings in the CHANGELOG, a DeprecationWarning until the next major release and a DeprecationError until the major release after that. Please note that adding warnings can be a breaking change for some users; most likely just in the CI. This means it needs to be properly documented. pypdf-6.1.2/docs/dev/documentation.md000066400000000000000000000027571507516550200175640ustar00rootroot00000000000000# Documentation ## API Reference ### Method / Function Docstrings We use Google-Style Docstrings: ``` def example(param1: int, param2: str) -> bool: """ Example function with PEP 484 type annotations. Args: param1: The first parameter. param2: The second parameter. Returns: The return value. True for success, False otherwise. Raises: AttributeError: The ``Raises`` section is a list of all exceptions that are relevant to the interface. ValueError: If `param2` is equal to `param1`. Examples: Examples should be written in doctest format, and should illustrate how to use the function. >>> print([i for i in example_generator(4)]) [0, 1, 2, 3] """ ``` * The order of sections is (1) Args (2) Returns (3) Raises (4) Examples * If there is no return value, remove the 'Returns' block * Properties should not have any sections ## Issues and PRs An issue can be used to discuss what we want to achieve. A PR can be used to discuss how we achieve it. ## Commit Messages We want to have descriptive commits in the `main` branch. For this reason, every pull request (PR) is squashed. That means no matter how many commits a PR has, in the end only one combined commit will be in `main`. The title of the PR will be used as the first line of that combined commit message. The first comment within the commit will be used as the message body. See [developer intro](intro.md#commit-messages) for more details. pypdf-6.1.2/docs/dev/intro.md000066400000000000000000000075621507516550200160450ustar00rootroot00000000000000# Developer Intro pypdf is a library and hence its users are developers. This document is not for the users, but for people who want to work on pypdf itself. ## Installing Requirements ``` pip install -r requirements/dev.txt ``` ## Running Tests See [testing pypdf with pytest](testing.md). ## The sample-files git submodule The reason for having the submodule `sample-files` is that we want to keep the size of the pypdf repository small while we also want to have an extensive test suite. Those two goals contradict each other. The `resources` folder should contain a select set of core examples that cover most cases we typically want to test for. The `sample-files` might cover a lot more edge cases, the behavior we get when file sizes get bigger, different PDF producers. To get the sample-files folder, you need to execute: ``` git submodule update --init ``` ## Tools: git and pre-commit Git is a command line application for version control. If you don't know it, you can [play ohmygit](https://ohmygit.org/) to learn it. GitHub is the service where the pypdf project is hosted. While git is free and open source, GitHub is a paid service by Microsoft, but free in a lot of cases. [pre-commit](https://pypi.org/project/pre-commit/) is a command line application that uses git hooks to automatically execute code. This allows you to avoid style issues and other code quality issues. After you entered `pre-commit install` once in your local copy of pypdf, it will automatically be executed when you `git commit`. ## Commit Messages Having a clean commit message helps people to quickly understand what the commit is about, without actually looking at the changes. The first line of the commit message is used to [auto-generate the CHANGELOG](https://github.com/py-pdf/pypdf/blob/main/make_release.py). For this reason, the format should be: ``` PREFIX: DESCRIPTION BODY ``` The `PREFIX` can be: * `SEC`: Security improvements. Typically, an infinite loop that was possible. * `BUG`: A bug was fixed. Likely there are one or multiple issues. Then write in the `BODY`: `Closes #123` where 123 is the issue number on GitHub. It would be absolutely amazing if you could write a regression test in those cases. That is a test that would fail without the fix. A bug is always an issue for pypdf users - test code or CI that was fixed is not considered a bug here. * `ENH`: A new feature! Describe in the body what it can be used for. * `DEP`: Deprecation. Either marking something as "this is going to be removed" or actually removing it. * `PI`: A performance improvement. This could also be a reduction in the file size of PDF files generated by pypdf. * `ROB`: A robustness change. Dealing better with broken PDF files. * `DOC`: A documentation change. * `TST`: Adding or adjusting tests. * `DEV`: Developer experience improvements, e.g., pre-commit or setting up CI. * `MAINT`: Quite a lot of different stuff. Performance improvements are, for sure, the most interesting changes in here. Refactorings as well. * `STY`: A style change. Something that makes pypdf code more consistent. Typically, a small change. It could also be better error messages for end users. The prefix is used to generate the CHANGELOG. Every PR must have exactly one - if you feel like several match, take the top one from this list that matches for your PR. ## Pull Request Size Smaller Pull Requests (PRs) are preferred as it's typically easier to merge them. For example, if you have some typos, a few code-style changes, a new feature, and a bug-fix, that could be three or four PRs. A PR must be complete. That means if you introduce a new feature, it must be finished within the PR and have a test for that feature. ## Benchmarks We need to keep an eye on performance, and thus we have a few benchmarks. See [py-pdf.github.io/pypdf/dev/bench](https://py-pdf.github.io/pypdf/dev/bench/) pypdf-6.1.2/docs/dev/pdf-format.md000066400000000000000000000112421507516550200167370ustar00rootroot00000000000000# The PDF Format It is recommended to look in the PDF specification for details and clarifications. * [PDF Specification Archive](https://pdfa.org/resource/pdf-specification-archive/) * [Portable Document Format Reference Manual, 1993. ISBN 0-201-62628-4](https://opensource.adobe.com/dc-acrobat-sdk-docs/pdfstandards/pdfreference1.0.pdf) * [ISO 32000-1:2008 (PDF 1.7)](https://opensource.adobe.com/dc-acrobat-sdk-docs/pdfstandards/PDF32000_2008.pdf) * ISO 32000-2:2020 (PDF 2.0) ```{note} We currently generate files with a header for PDF 1.3 by default. At the same time, we strive to support the PDF 1.7 specification. Features specific to PDF 2.0 might be available, but we always ensure that older versions do not break due to the rather limited general PDF 2.0 support in the wild and to not break for old PDF files. For this reason, some historical aspects (like insecure encryption algorithms) are required to be supported, although PDF 2.0 deprecates most of them and allows more secure variants. ``` Below is only intended to give a very rough overview of the format. ## Overall Structure A PDF consists of: 1. Header: Contains the version of the PDF, e.g. `%PDF-1.7` 2. Body: Contains a sequence of indirect objects 3. Cross-reference table (xref): Contains a list of the indirect objects in the body 4. Trailer ## The xref table A cross-reference table (xref) is a table of the indirect objects in the body. It allows quick access to those objects by pointing to their location in the file. It looks like this: ```text xref 42 5 0000001000 65535 f 0000001234 00000 n 0000001987 00000 n 0000011987 00000 n 0000031987 00000 n ``` Let's go through it step-by-step: * `xref` is just a keyword that specifies the start of the xref table. * `42` is the numerical ID of the first object in this xref section; `5` is the number of entries in the xref table. * Now every object has 3 entries `nnnnnnnnnn ggggg n`: a 10-digit byte offset, a 5-digit generation number, and a literal keyword which is either `n` or `f`. * `nnnnnnnnnn` is the byte offset of the object. It tells the reader where the object is in the file. * `ggggg` is the generation number. It tells the reader how old the object is. * `n` means that the object is a normal in-use object, `f` means that the object is a free object. * The first free object always has a generation number of 65535. It forms the head of a linked-list of all free objects. * The generation number of a normal object is always 0. The generation number allows the PDF format to contain multiple versions of the same object. This is a version history mechanism. ## The body The body is a sequence of indirect objects: `counter generation_number << the_object >> endobj` * `counter` (integer) is a unique identifier for the object. * `generation_number` (integer) is the generation number of the object. * `the_object` is the object itself. It can be empty. Starts with `/Keyword` to specify which kind of object it is. * `endobj` marks the end of the object. A concrete example can be found in `test_reader.py::test_get_images_raw`: ```text 1 0 obj << /Count 1 /Kids [4 0 R] /Type /Pages >> endobj 2 0 obj << >> endobj 3 0 obj << >> endobj 4 0 obj << /Contents 3 0 R /CropBox [0.0 0.0 2550.0 3508.0] /MediaBox [0.0 0.0 2550.0 3508.0] /Parent 1 0 R /Resources << /Font << >> >> /Rotate 0 /Type /Page >> endobj 5 0 obj << /Pages 1 0 R /Type /Catalog >> endobj ``` ## The trailer The trailer looks like this: ```text trailer << /Root 5 0 R /Size 6 >> startxref 1234 %%EOF ``` Let's go through it: * `trailer <<` indicates that the *trailer dictionary* starts. It ends with `>>`. * `startxref` is a keyword followed by the byte-location of the `xref` keyword. As the trailer is always at the bottom of the file, this allows readers to quickly find the xref table. * `%%EOF` is the end-of-file marker. The trailer dictionary is a key-value list. The keys are specified in Table 15 of the PDF Reference 1.7, e.g. `/Root` and `/Size` (both are required). * `/Root` (dictionary) contains the document catalog. * The `5` is the object number of the catalog dictionary. * `0` is the generation number of the catalog dictionary. * `R` is the keyword that indicates that the object is a reference to the catalog dictionary. * `/Size` (integer) contains the total number of entries in the files xref table. ## Reading PDF files Most PDF files are compressed. If you want to read them, first uncompress them: ```bash pdftk crazyones.pdf output crazyones-uncomp.pdf uncompress ``` Then rename `crazyones-uncomp.pdf` to `crazyones-uncomp.txt` and open it in your favorite IDE / text editor. pypdf-6.1.2/docs/dev/pypdf-parsing.md000066400000000000000000000031561507516550200174700ustar00rootroot00000000000000# How pypdf parses PDF files pypdf uses {class}`~pypdf.PdfReader` to parse PDF files. The method {py:meth}`PdfReader.read ` shows the basic structure of parsing: 1. **Finding and reading the cross-reference tables / trailer**: The cross-reference table (xref table) is a table of byte offsets that indicate the locations of objects within the file. The trailer provides additional information such as the root object (Catalog) and the Info object containing metadata. 2. **Parsing the objects**: After locating the xref table and the trailer, pypdf proceeds to parse the objects in the PDF. Objects in a PDF can be of various types such as dictionaries, arrays, streams, and simple data types (e.g., integers, strings). pypdf parses these objects and stores them in {py:meth}`PdfReader.resolved_objects `, populated by {py:meth}`cache_indirect_object `. 3. **Decoding content streams**: The content of a PDF is typically stored in content streams, which are sequences of PDF operators and operands. pypdf decodes these content streams by applying filters (e.g., `FlateDecode`, `LZWDecode`) specified in the stream's dictionary. This is only done when the object is requested by {py:meth}`PdfReader.get_object ` which uses the `PdfReader._get_object_from_stream` method. ## References [PDF 1.7 specification](https://opensource.adobe.com/dc-acrobat-sdk-docs/pdfstandards/PDF32000_2008.pdf): * 7.5 File Structure * 7.5.4 Cross-Reference Table * 7.8 Content Streams and Resources pypdf-6.1.2/docs/dev/pypdf-writing.md000066400000000000000000000074671507516550200175210ustar00rootroot00000000000000# How pypdf writes PDF files pypdf uses {py:class}`PdfWriter ` to write PDF files. pypdf has {py:class}`PdfObject ` and several subclasses with the {py:meth}`write_to_stream ` method. The {py:meth}`PdfWriter.write ` method uses the `write_to_stream` methods of the referenced objects. The {py:meth}`PdfWriter.write_stream ` method has the following core steps: 1. `_sweep_indirect_references`: This step ensures that any circular references to objects are correctly handled. It adds the object reference numbers of any circularly referenced objects to an external reference map, so that self-page-referencing trees can reference the correct new object location, rather than copying in a new copy of the page object. 2. **Write the File Header and Body** with `_write_pdf_structure`: In this step, the PDF header and objects are written to the output stream. This includes the PDF version (e.g., %PDF-1.7) and the objects that make up the content of the PDF, such as pages, annotations, and form fields. The locations (byte offsets) of these objects are stored for later use in generating the xref table. 3. **Write the Cross-Reference Table** with `_write_xref_table`: Using the stored object locations, this step generates and writes the cross-reference table (xref table) to the output stream. The cross-reference table contains the byte offsets for each object in the PDF file, allowing for quick random access to objects when reading the PDF. 4. **Write the File Trailer** with `_write_trailer`: The trailer is written to the output stream in this step. The trailer contains essential information, such as the number of objects in the PDF, the location of the root object (Catalog), and the Info object containing metadata. The trailer also specifies the location of the xref table. ## How others do it Looking at alternative software designs and implementations can help to improve our choices. ### fpdf2 [fpdf2](https://pypi.org/project/fpdf2/) has a [`PDFObject` class](https://github.com/PyFPDF/fpdf2/blob/master/fpdf/syntax.py) with a serialize method which roughly maps to `pypdf.PdfObject.write_to_stream`. Some other similarities include: * [fpdf.output.OutputProducer.buffersize](https://github.com/PyFPDF/fpdf2/blob/master/fpdf/output.py#L370-L485) vs. {py:meth}`pypdf.PdfWriter.write_stream ` * [fpdpf.syntax.Name](https://github.com/PyFPDF/fpdf2/blob/master/fpdf/syntax.py#L124) vs. {py:class}`pypdf.generic.NameObject ` * [fpdf.syntax.build_obj_dict](https://github.com/PyFPDF/fpdf2/blob/master/fpdf/syntax.py#L222) vs. {py:class}`pypdf.generic.DictionaryObject ` * [fpdf.structure_tree.NumberTree](https://github.com/PyFPDF/fpdf2/blob/master/fpdf/structure_tree.py#L17) vs. {py:class}`pypdf.generic.TreeObject ` ### pdfrw [pdfrw](https://pypi.org/project/pdfrw/), in contrast, seems to work more with the standard Python objects (bool, float, string) and not wrap them in custom objects, if possible. It still has: * [PdfArray](https://github.com/pmaupin/pdfrw/blob/master/pdfrw/objects/pdfarray.py#L13) * [PdfDict](https://github.com/pmaupin/pdfrw/blob/master/pdfrw/objects/pdfdict.py#L49) * [PdfName](https://github.com/pmaupin/pdfrw/blob/master/pdfrw/objects/pdfname.py#L65) * [PdfString](https://github.com/pmaupin/pdfrw/blob/master/pdfrw/objects/pdfstring.py#L322) * [PdfIndirect](https://github.com/pmaupin/pdfrw/blob/master/pdfrw/objects/pdfindirect.py#L10) The core classes of pdfrw are [PdfReader](https://github.com/pmaupin/pdfrw/blob/master/pdfrw/pdfreader.py#L26) and [PdfWriter](https://github.com/pmaupin/pdfrw/blob/master/pdfrw/pdfwriter.py#L224) pypdf-6.1.2/docs/dev/releasing.md000066400000000000000000000044401507516550200166530ustar00rootroot00000000000000# Releasing A `pypdf` release contains the following artifacts: * A new [release on PyPI](https://pypi.org/project/pypdf/) * A [release commit](https://github.com/py-pdf/pypdf/commit/91391b18bb8ec9e6e561e2795d988e8634a01a50) * Containing a changelog update * A new [git tag](https://github.com/py-pdf/pypdf/tags) * A [GitHub release](https://github.com/py-pdf/pypdf/releases/tag/3.15.0) ## Who does it? `pypdf` should typically only be released by one of the core maintainers / the core maintainer. At the moment, this is either stefan6419846 or pubpub-zz and Martin Thoma. Any owner of the py-pdf organization also has the technical permissions to release. ## How is it done? ### With direct push permissions This is the typical way for the core maintainer/benevolent dictator. The release contains the following steps: 1. Update the CHANGELOG.md and the _version.py via `python make_release.py`. This also prepares the release commit message. 2. Create a release commit: `git commit -eF RELEASE_COMMIT_MSG.md`. 3. Push commit: `git push`. 4. CI now builds a source and a wheels package which it pushes to PyPI. It also creates the corresponding tag and a GitHub release. ![](../_static/releasing.drawio.png) ### Using a Pull Request This is the typical way for collaborators which do not have direct push permissions for the `main` branch. The release contains the following steps: 1. Update the CHANGELOG.md and the _version.py via `python make_release.py`. This also prepares the release commit message. 2. Push the changes to a dedicated branch. 3. Open a pull request starting with `REL: `, followed by the new version number. 4. Wait for the approval of another eligible maintainer. 5. Merge the pull request with the name being the PR title and the body being the content of `RELEASE_COMMIT_MSG.md`. 6. CI now builds a source and a wheels package which it pushes to PyPI. It also creates the corresponding tag and a GitHub release. ### The Release Tag * Use the release version as the tag name. No need for a leading "v". * Use the changelog entry as the body. ## When are releases done? There is no need to wait for anything. If the CI is green (all tests succeeded), we can release. At the moment, there is no fixed release cycle - except that we usually release on Sunday. pypdf-6.1.2/docs/dev/testing.md000066400000000000000000000045031507516550200163570ustar00rootroot00000000000000# Testing pypdf uses [`pytest`](https://docs.pytest.org/en/7.1.x/) for testing. To run the tests, you need to install the CI (Continuous Integration) requirements by running `pip install -r requirements/ci.txt` or `pip install -r requirements/ci-3.11.txt` if running Python ≥ 3.11. ## Deselecting groups of tests pypdf makes use of the following pytest markers: * `slow`: Tests that require more than 5 seconds. * `samples`: Tests that require [the `sample-files` git submodule](https://github.com/py-pdf/sample-files) to be initialized. As of October 2022, this is about 25 MB. * `enable_socket`: Tests that download PDF documents. They are stored locally and thus only need to be downloaded once. As of October 2022, this is about 200 MB. * To successfully run the tests, please download most of the documents beforehand: `python -c "from tests import download_test_pdfs; download_test_pdfs()"` You can disable them by `pytest -m "not enable_socket"` or `pytest -m "not samples"`. You can even disable all of them: `pytest -m "not enable_socket" -m "not samples" -m "not slow"`. Please note that this reduces test coverage. The CI will always test all files. ## Docstrings in Unit tests The first line of a docstring in a unit test should be written in a way that you could prefix it with "This tests ensures that ...", e.g. * Invalid XML in xmp_metadata is gracefully handled. * The identity is returning its input. * xmp_modify_date is extracted correctly. This way, plugins like [`pytest-testdox`](https://pypi.org/project/pytest-testdox/) can generate really nice output when the tests are running. This looks similar to the output of [mocha.js](https://mochajs.org/). If the test is a regression test, write > This test is a regression test for issue #1234 If the regression test is just one parameter of other tests, then add it as a comment for that parameter. ## Evaluate a PR in-progress version You may want to test a version from a PR which has not been released yet. The easiest way is to use pip and install a version from git: a) Go the PR and identify the repository and branch. Example from below : repository: __pubpub-zz__ / branch: __iss2200__ : ![PR Header example](PR_Header_example.png) b) you can then install the version using pip from git: Example: ``` pip install git+https://github.com/pubpub-zz/pypdf.git@iss2200 ``` pypdf-6.1.2/docs/index.rst000066400000000000000000000044461507516550200154510ustar00rootroot00000000000000.. pypdf documentation main file, created by sphinx-quickstart on Thu Apr 7 20:13:19 2022. You can adapt this file completely to your liking, but it should at least contain the root `toctree` directive. Welcome to pypdf ================= pypdf is a `free `_ and open source pure-python PDF library capable of splitting, merging, cropping, and transforming the pages of PDF files. It can also add custom data, viewing options, and passwords to PDF files. pypdf can retrieve text and metadata from PDFs as well. See `pdfly `_ for a CLI application that uses pypdf to interact with PDFs. You can contribute to `pypdf on GitHub `_. .. toctree:: :caption: User Guide :maxdepth: 1 user/installation user/migration-1-to-2 user/robustness user/suppress-warnings user/metadata user/extract-text user/post-processing-in-text-extraction user/extract-images user/handle-attachments user/encryption-decryption user/merging-pdfs user/cropping-and-transforming user/reading-pdf-annotations user/adding-pdf-annotations user/add-watermark user/add-javascript user/viewer-preferences user/forms user/streaming-data user/file-size user/pdf-version-support user/pdfa-compliance .. toctree:: :caption: API Reference :maxdepth: 1 modules/PdfReader modules/PdfWriter modules/Destination modules/DocumentInformation modules/Field modules/Fit modules/PageObject modules/PageRange modules/PaperSize modules/RectangleObject modules/Transformation modules/XmpInformation modules/annotations modules/constants modules/errors modules/generic modules/PdfDocCommon .. toctree:: :caption: Developer Guide :maxdepth: 1 dev/intro dev/pdf-format dev/pypdf-parsing dev/pypdf-writing dev/cmaps dev/deprecations dev/documentation dev/testing dev/releasing .. toctree:: :caption: About pypdf :maxdepth: 1 meta/CHANGELOG meta/changelog-v1 meta/project-governance meta/taking-ownership meta/history meta/CONTRIBUTORS meta/scope-of-pypdf meta/comparisons meta/faq Indices and tables ================== * :ref:`genindex` * :ref:`modindex` * :ref:`search` pypdf-6.1.2/docs/make.bat000066400000000000000000000014401507516550200152040ustar00rootroot00000000000000@ECHO OFF pushd %~dp0 REM Command file for Sphinx documentation if "%SPHINXBUILD%" == "" ( set SPHINXBUILD=sphinx-build ) set SOURCEDIR=. set BUILDDIR=_build %SPHINXBUILD% >NUL 2>NUL if errorlevel 9009 ( echo. echo.The 'sphinx-build' command was not found. Make sure you have Sphinx echo.installed, then set the SPHINXBUILD environment variable to point echo.to the full path of the 'sphinx-build' executable. Alternatively you echo.may add the Sphinx directory to PATH. echo. echo.If you don't have Sphinx installed, grab it from echo.https://www.sphinx-doc.org/ exit /b 1 ) if "%1" == "" goto help %SPHINXBUILD% -M %1 %SOURCEDIR% %BUILDDIR% %SPHINXOPTS% %O% goto end :help %SPHINXBUILD% -M help %SOURCEDIR% %BUILDDIR% %SPHINXOPTS% %O% :end popd pypdf-6.1.2/docs/meta/000077500000000000000000000000001507516550200145265ustar00rootroot00000000000000pypdf-6.1.2/docs/meta/changelog-v1.md000066400000000000000000001026011507516550200173230ustar00rootroot00000000000000# Changelog of PyPDF2 1.X ## Version 1.28.4, 2022-05-29 Bug Fixes (BUG): - XmpInformation._converter_date was unusable (#921) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/1.28.3...1.28.4) ## Version 1.28.3, 2022-05-28 ### Deprecations (DEP) - PEP8 renaming (#905) ### Bug Fixes (BUG) - XmpInformation missing method _getText (#917) - Fix PendingDeprecationWarning on _merge_page (#904) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/1.28.2...1.28.3) ## Version 1.28.2, 2022-05-23 ### Bug Fixes (BUG) - PendingDeprecationWarning for getContents (#893) - PendingDeprecationWarning on using PdfMerger (#891) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/1.28.1...1.28.2) ## Version 1.28.1, 2022-05-22 ### Bug Fixes (BUG) - Incorrectly show deprecation warnings on internal usage (#887) ### Maintenance (MAINT) - Add stacklevel=2 to deprecation warnings (#889) - Remove duplicate warnings imports (#888) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/1.28.0...1.28.1) ## Version 1.28.0, 2022-05-22 This release adds a lot of deprecation warnings in preparation of the PyPDF2 2.0.0 release. The changes are mostly using snake_case function-, method-, and variable-names as well as using properties instead of getter-methods. Maintenance (MAINT): - Remove IronPython Fallback for zlib (#868) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/1.27.12...1.27.13) ### Deprecations (DEP) * Make the `PyPDF2.utils` module private * Rename of core classes: * PdfFileReader âž” PdfReader * PdfFileWriter âž” PdfWriter * PdfFileMerger âž” PdfMerger * Use PEP8 conventions for function names and parameters * If a property and a getter-method are both present, use the property #### Details In many places: - getObject âž” get_object - writeToStream âž” write_to_stream - readFromStream âž” read_from_stream PyPDF2.generic - readObject âž” read_object - convertToInt âž” convert_to_int - DocumentInformation.getText âž” DocumentInformation._get_text : This method should typically not be used; please let me know if you need it. PdfReader class: - `reader.getPage(pageNumber)` âž” `reader.pages[page_number]` - `reader.getNumPages()` / `reader.numPages` âž” `len(reader.pages)` - getDocumentInfo âž” metadata - flattenedPages attribute âž” flattened_pages - resolvedObjects attribute âž” resolved_objects - xrefIndex attribute âž” xref_index - getNamedDestinations / namedDestinations attribute âž” named_destinations - getPageLayout / pageLayout âž” page_layout attribute - getPageMode / pageMode âž” page_mode attribute - getIsEncrypted / isEncrypted âž” is_encrypted attribute - getOutlines âž” get_outlines - readObjectHeader âž” read_object_header - cacheGetIndirectObject âž” cache_get_indirect_object - cacheIndirectObject âž” cache_indirect_object - getDestinationPageNumber âž” get_destination_page_number - readNextEndLine âž” read_next_end_line - _zeroXref âž” _zero_xref - _authenticateUserPassword âž” _authenticate_user_password - _pageId2Num attribute âž” _page_id2num - _buildDestination âž” _build_destination - _buildOutline âž” _build_outline - _getPageNumberByIndirect(indirectRef) âž” _get_page_number_by_indirect(indirect_ref) - _getObjectFromStream âž” _get_object_from_stream - _decryptObject âž” _decrypt_object - _flatten(..., indirectRef) âž” _flatten(..., indirect_ref) - _buildField âž” _build_field - _checkKids âž” _check_kids - _writeField âž” _write_field - _write_field(..., fieldAttributes) âž” _write_field(..., field_attributes) - _read_xref_subsections(..., getEntry, ...) âž” _read_xref_subsections(..., get_entry, ...) PdfWriter class: - `writer.getPage(pageNumber)` âž” `writer.pages[page_number]` - `writer.getNumPages()` âž” `len(writer.pages)` - addMetadata âž” add_metadata - addPage âž” add_page - addBlankPage âž” add_blank_page - addAttachment(fname, fdata) âž” add_attachment(filename, data) - insertPage âž” insert_page - insertBlankPage âž” insert_blank_page - appendPagesFromReader âž” append_pages_from_reader - updatePageFormFieldValues âž” update_page_form_field_values - cloneReaderDocumentRoot âž” clone_reader_document_root - cloneDocumentFromReader âž” clone_document_from_reader - getReference âž” get_reference - getOutlineRoot âž” get_outline_root - getNamedDestRoot âž” get_named_dest_root - addBookmarkDestination âž” add_bookmark_destination - addBookmarkDict âž” add_bookmark_dict - addBookmark âž” add_bookmark - addNamedDestinationObject âž” add_named_destination_object - addNamedDestination âž” add_named_destination - removeLinks âž” remove_links - removeImages(ignoreByteStringObject) âž” remove_images(ignore_byte_string_object) - removeText(ignoreByteStringObject) âž” remove_text(ignore_byte_string_object) - addURI âž” add_uri - addLink âž” add_link - getPage(pageNumber) âž” get_page(page_number) - getPageLayout / setPageLayout / pageLayout âž” page_layout attribute - getPageMode / setPageMode / pageMode âž” page_mode attribute - _addObject âž” _add_object - _addPage âž” _add_page - _sweepIndirectReferences âž” _sweep_indirect_references PdfMerger class - `__init__` parameter: strict=True âž” strict=False (the PdfFileMerger still has the old default) - addMetadata âž” add_metadata - addNamedDestination âž” add_named_destination - setPageLayout âž” set_page_layout - setPageMode âž” set_page_mode Page class: - artBox / bleedBox/ cropBox/ mediaBox / trimBox âž” artbox / bleedbox/ cropbox/ mediabox / trimbox - getWidth, getHeight âž” width / height - getLowerLeft_x / getUpperLeft_x âž” left - getUpperRight_x / getLowerRight_x âž” right - getLowerLeft_y / getLowerRight_y âž” bottom - getUpperRight_y / getUpperLeft_y âž” top - getLowerLeft / setLowerLeft âž” lower_left property - upperRight âž” upper_right - mergePage âž” merge_page - rotateClockwise / rotateCounterClockwise âž” rotate_clockwise - _mergeResources âž” _merge_resources - _contentStreamRename âž” _content_stream_rename - _pushPopGS âž” _push_pop_gs - _addTransformationMatrix âž” _add_transformation_matrix - _mergePage âž” _merge_page XmpInformation class: - getElement(..., aboutUri, ...) âž” get_element(..., about_uri, ...) - getNodesInNamespace(..., aboutUri, ...) âž” get_nodes_in_namespace(..., aboutUri, ...) - _getText âž” _get_text utils.py: - matrixMultiply âž” matrix_multiply - RC4_encrypt is moved to the security module ## Version 1.27.12, 2022-05-02 ### Bug Fixes (BUG) - _rebuild_xref_table expects trailer to be a dict (#857) ### Documentation (DOC) - Security Policy [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/1.27.11...1.27.12) ## Version 1.27.11, 2022-05-02 ### Bug Fixes (BUG) - Incorrectly issued xref warning/exception (#855) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/1.27.10...1.27.11) ## Version 1.27.10, 2022-05-01 ### Robustness (ROB) - Handle missing destinations in reader (#840) - warn-only in readStringFromStream (#837) - Fix corruption in startxref or xref table (#788 and #830) ### Documentation (DOC) - Project Governance (#799) - History of PyPDF2 - PDF feature/version support (#816) - More details on text parsing issues (#815) ### Developer Experience (DEV) - Add benchmark command to Makefile - Ignore IronPython parts for code coverage (#826) ### Maintenance (MAINT) - Split pdf module (#836) - Separated CCITTFax param parsing/decoding (#841) - Update requirements files ### Testing (TST) - Use external repository for larger/more PDFs for testing (#820) - Swap incorrect test names (#838) - Add test for PdfFileReader and page properties (#835) - Add tests for PyPDF2.generic (#831) - Add tests for utils, form fields, PageRange (#827) - Add test for ASCII85Decode (#825) - Add test for FlateDecode (#823) - Add test for filters.ASCIIHexDecode (#822) ### Code Style (STY) - Apply pre-commit (black, isort) + use snake_case variables (#832) - Remove debug code (#828) - Documentation, Variable names (#839) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/1.27.9...1.27.10) ## Version 1.27.9, 2022-04-24 A change I would like to highlight is the performance improvement for large PDF files (#808) 🎉 ### New Features (ENH) - Add papersizes (#800) - Allow setting permission flags when encrypting (#803) - Allow setting form field flags (#802) ### Bug Fixes (BUG) - TypeError in xmp._converter_date (#813) - Improve spacing for text extraction (#806) - Fix PDFDocEncoding Character Set (#809) ### Robustness (ROB) - Use null ID when encrypted but no ID given (#812) - Handle recursion error (#804) ### Documentation (DOC) - CMaps (#811) - The PDF Format + commit prefixes (#810) - Add compression example (#792) ### Developer Experience (DEV) - Add Benchmark for Performance Testing (#781) ### Maintenance (MAINT) - Validate PDF magic byte in strict mode (#814) - Make PdfFileMerger.addBookmark() behave life PdfFileWriters' (#339) - Quadratic runtime while parsing reduced to linear (#808) ### Testing (TST) - Newlines in text extraction (#807) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/1.27.8...1.27.9) ## Version 1.27.8, 2022-04-21 ### Bug Fixes (BUG) - Use 1MB as offset for readNextEndLine (#321) - 'PdfFileWriter' object has no attribute 'stream' (#787) ### Robustness (ROB) - Invalid float object; use 0 as fallback (#782) ### Documentation (DOC) - Robustness (#785) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/1.27.7...1.27.8) ## Version 1.27.7, 2022-04-19 ### Bug Fixes (BUG) - Import exceptions from PyPDF2.errors in PyPDF2.utils (#780) ### Code Style (STY) - Naming in 'make_changelog.py' ## Version 1.27.6, 2022-04-18 ### Deprecations (DEP) - Remove support for Python 2.6 and older (#776) ### New Features (ENH) - Extract document permissions (#320) ### Bug Fixes (BUG) - Clip by trimBox when merging pages, which would otherwise be ignored (#240) - Add overwriteWarnings parameter PdfFileMerger (#243) - IndexError for getPage() of decrypted file (#359) - Handle cases where decodeParms is an ArrayObject (#405) - Updated PDF fields don't show up when page is written (#412) - Set Linked Form Value (#414) - Fix zlib -5 error for corrupt files (#603) - Fix reading more than last1K for EOF (#642) - Accidental import ### Robustness (ROB) - Allow extra whitespace before "obj" in readObjectHeader (#567) ### Documentation (DOC) - Link to pdftoc in Sample_Code (#628) - Working with annotations (#764) - Structure history ### Developer Experience (DEV) - Add issue templates (#765) - Add tool to generate changelog ### Maintenance (MAINT) - Use grouped constants instead of string literals (#745) - Add error module (#768) - Use decorators for @staticmethod (#775) - Split long functions (#777) ### Testing (TST) - Run tests in CI once with -OO Flags (#770) - Filling out forms (#771) - Add tests for Writer (#772) - Error cases (#773) - Check Error messages (#769) - Regression test for issue #88 - Regression test for issue #327 ### Code Style (STY) - Make variable naming more consistent in tests [Full changelog](https://github.com/py-pdf/PyPDF2/compare/1.27.5...1.27.6) ## Version 1.27.5, 2022-04-15 ### Security (SEC) - ContentStream_readInlineImage had potential infinite loop (#740) ### Bug fixes (BUG) - Fix merging encrypted files (#757) - CCITTFaxDecode decodeParms can be an ArrayObject (#756) ### Robustness improvements (ROBUST) - title sometimes None (#744) ### Documentation (DOC) - Adjust short description of the package ### Tests and Test setup (TST) - Rewrite JS tests from unittest to pytest (#746) - Increase Test coverage, mainly with filters (#756) - Add test for inline images (#758) ### Developer Experience Improvements (DEV) - Remove unused Travis-CI configuration (#747) - Show code coverage (#754, #755) - Add mutmut (#760) ### Miscellaneous - STY: Closing file handles, explicit exports, ... (#743) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/1.27.4...1.27.5) ## Version 1.27.4, 2022-04-12 ### Bug fixes (BUG) - Guard formatting of `__init__.__doc__` string (#738) ### Packaging (PKG) - Add more precise license field to setup (#733) ### Testing (TST) - Add test for issue #297 ### Miscellaneous - DOC: Miscallenious âž” Miscellaneous (Typo) - TST: Fix CI triggering (master âž” main) (#739) - STY: Fix various style issues (#742) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/1.27.3...1.27.4) ## Version 1.27.3, 2022-04-10 - PKG: Make Tests not a subpackage (#728) - BUG: Fix ASCII85Decode.decode assertion (#729) - BUG: Error in Chinese character encoding (#463) - BUG: Code duplication in Scripts/2-up.py - ROBUST: Guard 'obj.writeToStream' with 'if obj is not None' - ROBUST: Ignore a /Prev entry with value 0 in the trailer - MAINT: Remove Sample_Code (#726) - TST: Close file handle in test_writer (#722) - TST: Fix test_get_images (#730) - DEV: Make tox use pytest and add more Python versions (#721) - DOC: Many (#720, #723-725, #469) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/1.27.2...1.27.3) ## Version 1.27.2, 2022-04-09 - Add Scripts (including `pdfcat`), Resources, Tests, and Sample_Code back to PyPDF2. It was removed by accident in 1.27.0, but might get removed with 2.0.0 See [discussions/718](https://github.com/py-pdf/PyPDF2/discussions/718). [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/1.27.1...1.27.2) ## Version 1.27.1, 2022-04-08 - Fixed project links on PyPI page after migration from mstamy2 to MartinThoma to the py-pdf organization on GitHub - Documentation is now at [pypdf2.readthedocs.io](https://pypdf2.readthedocs.io/en/latest/) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/1.27.0...1.27.1) ## Version 1.27.0, 2022-04-07 Features: - Add alpha channel support for png files in Script (#614) ### Bug fixes (BUG) - Fix formatWarning for filename without slash (#612) - Add whitespace between words for extractText() (#569, #334) - "invalid escape sequence" SyntaxError (#522) - Avoid error when printing warning in pythonw (#486) - Stream operations can be List or Dict (#665) ### Documentation (DOC) - Added Scripts/pdf-image-extractor.py - Documentation improvements (#550, #538, #324, #426, #394) ### Tests and Test setup (TST) - Add GitHub Action which automatically runs unit tests via pytest and static code analysis with Flake8 (#660) - Add several unit tests (#661, #663) - Add .coveragerc to create coverage reports ### Developer Experience Improvements (DEV) - Pre commit: Developers can now `pre-commit install` to avoid tiny issues like trailing whitespaces ### Miscellaneous - Add the LICENSE file to the distributed packages (#288) - Use setuptools instead of distutils (#599) - Improvements for the PyPI page (#644) - Python 3 changes (#504, #366) [Full Changelog](https://github.com/py-pdf/PyPDF2/compare/1.26.0...1.27.0) ## Version 1.26.0, 2016-05-18 - NOTE: Active maintenance on PyPDF2 is resuming after a hiatus - Fixed a bug where image resources where incorrectly overwritten when merging pages - Added dictionary for JavaScript actions to the root (louib) - Added unit tests for the JS functionality (louib) - Add more Python 3 compatibility when reading inline images (im2703 and (VyacheslavHashov) - Return NullObject instead of raising error when failing to resolve object (ctate) - Don't output warning for non-zeroed xref table when strict=False (BenRussert) - Remove extraneous zeroes from output formatting (speedplane) - Fix bug where reading an inline image would cut off prematurely in certain cases (speedplane) ## Version 1.25.1, 2015-07-20 - Fix bug when parsing inline images. Occurred when merging certain pages with inline images - Fixed type error when creating outlines by utilizing the isString() test ## Version 1.25, 2015-07-07 BUGFIXES: - Added Python 3 algorithm for ASCII85Decode. Fixes issue when reading reportlab-generated files with Py 3 (jerickbixly) - Recognize more escape sequence which would otherwise throw an exception (manuelzs, robertsoakes) - Fixed overflow error in generic.py. Occurred when reading a too-large int in Python 2 (by Raja Jamwal) - Allow access to files which were encrypted with an empty password. Previously threw a "File has not been decrypted" exception (Elena Williams) - Do not attempt to decode an empty data stream. Previously would cause an error in decode algorithms (vladir) - Fixed some type issues specific to Py 2 or Py 3 - Fix issue when stream data begins with whitespace (soloma83) - Recognize abbreviated filter names (AlmightyOatmeal and Matthew Weiss) - Copy decryption key from PdfFileReader to PdfFileMerger. Allows usage of PdfFileMerger with encrypted files (twolfson) - Fixed bug which occurred when a NameObject is present at end of a file stream. Threw a "Stream has ended unexpectedly" exception (speedplane) FEATURES: - Initial work on a test suite; to be expanded in future. Tests and Resources directory added, README updated (robertsoakes) - Added document cloning methods to PdfFileWriter: appendPagesFromReader, cloneReaderDocumentRoot, and cloneDocumentFromReader. See official documentation (robertsoakes) - Added method for writing to form fields: updatePageFormFieldValues. This will be enhanced in the future. See official documentation (robertsoakes) - New addAttachment method. See documentation. Support for adding and extracting embedded files to be enhanced in the future (moshekaplan) - Added methods to get page number of given PageObject or Destination: getPageNumber and getDestinationPageNumber. See documentation (mozbugbox) OTHER ENHANCEMENTS: - Enhanced type handling (Brent Amrhein) - Enhanced exception handling in NameObject (sbywater) - Enhanced extractText method output (peircej) - Better exception handling - Enhanced regex usage in NameObject class (speedplane) ## Version 1.24, 2014-12-31 - Bugfixes for reading files in Python 3 (by Anthony Tuininga and pqqp) - Appropriate errors are now raised instead of infinite loops (by naure and Cyrus Vafadari) - Bugfix for parsing number tokens with leading spaces (by Maxim Kamenkov) - Don't crash on bad /Outlines reference (by eshellman) - Conform tabs/spaces and blank lines to PEP 8 standards - Utilize the readUntilRegex method when reading Number Objects (by Brendan Jurd) - More bugfixes for Python 3 and clearer exception handling - Fixed encoding issue in merger (with eshellman) - Created separate folder for scripts ## Version 1.23, 2014-08-11 - Documentation now available at pythonhosted.org - Bugfix in pagerange.py for when `__init__.__doc__` has no value (by Vladir Cruz) - Fix typos in OutlinesObject().add() (by shilluc) - Re-added a missing return statement in a utils.py method - Corrected viewing mode names (by Jason Scheirer) - New PdfFileWriter method: addJS() (by vfigueiro) - New bookmark features: color, boldness, italics, and page fit (by Joshua Arnott) - New PdfFileReader method: getFields(). Used to extract field information from PDFs with interactive forms. See documentation for details - Converted README file to markdown format (by Stephen Bussard) - Several improvements to overall performance and efficiency (by mozbugbox) - Fixed a bug where geospatial information was not scaling along with its page - Fixed a type issue and a Python 3 issue in the decryption algorithms (with Francisco Vieira and koba-ninkigumi) - Fixed a bug causing an infinite loop in the ASCII 85 decoding algorithm (by madmaardigan) - Annotations (links, comment windows, etc.) are now preserved when pages are merged together - Used the Destination class in addLink() and addBookmark() so that the page fit option could be properly customized ## Version 1.22, 2014-05-29 - Added .DS_Store to .gitignore (for Mac users) (by Steve Witham) - Removed `__init__()` implementation in NameObject (by Steve Witham) - Fixed bug (inf. loop) when merging pages in Python 3 (by commx) - Corrected error when calculating height in scaleTo() - Removed unnecessary code from DictionaryObject (by Georges Dubus) - Fixed bug where an exception was thrown upon reading a NULL string (by speedplane) - Allow string literals (non-unicode strings in Python 2) to be passed to PdfFileReader - Allow ConvertFunctionsToVirtualList to be indexed with slices and longs (in Python 2) (by Matt Gilson) - Major improvements and bugfixes to addLink() method (see documentation in source code) (by Henry Keiter) - General code clean-up and improvements (with Steve Witham and Henry Keiter) - Fixed bug that caused crash when comments are present at end of dictionary ## Version 1.21, 2014-04-21 - Fix for when /Type isn't present in the Pages dictionary (by Rob1080) - More tolerance for extra whitespace in Indirect Objects - Improved Exception handling - Fixed error in getHeight() method (by Simon Kaempflein) - implement use of utils.string_type to resolve Py2-3 compatibility issues - Prevent exception for multiple definitions in a dictionary (with carlosfunk) (only when strict = False) - Fixed errors when parsing a slice using pdfcat on command line (by Steve Witham) - Tolerance for EOF markers within 1024 bytes of the actual end of the file (with David Wolever) - Added overwriteWarnings parameter to PdfFileReader constructor, if False PyPDF2 will NOT overwrite methods from Python's warnings.py module with a custom implementation. - Fix NumberObject and NameObject constructors for compatibility with PyPy (RĂĽdiger Jungbeck, Xavier DuprĂ©, shezadkhan137, Steven Witham) - Utilize utils.Str in pdf.py and pagerange.py to resolve type issues (by egbutter) - Improvements in implementing StringIO for Python 2 and BytesIO for Python 3 (by Xavier DuprĂ©) - Added /x00 to Whitespaces, defined utils.WHITESPACES to clarify code (by Maxim Kamenkov) - Bugfix for merging 3 or more resources with the same name (by lucky-user) - Improvements to Xref parsing algorithm (by speedplane) ## Version 1.20, 2014-01-27 - Official Python 3+ support (with contributions from TWAC and cgammans) Support for Python versions 2.6 and 2.7 will be maintained - Command line concatenation (see pdfcat in sample code) (by Steve Witham) - New FAQ; link included in README - Allow more (although unnecessary) escape sequences - Prevent exception when reading a null object in decoding parameters - Corrected error in reading destination types (added a slash since they are name objects) - Corrected TypeError in scaleTo() method - addBookmark() method in PdfFileMerger now returns bookmark (so nested bookmarks can be created) - Additions to Sample Code and Sample PDFs - changes to allow 2up script to work (see sample code) (by Dylan McNamee) - changes to metadata encoding (by Chris Hiestand) - New methods for links: addLink() (by Enrico Lambertini) and removeLinks() - Bugfix to handle nested bookmarks correctly (by Jamie Lentin) - New methods removeImages() and removeText() available for PdfFileWriter (by Tien HaĂŻ) - Exception handling for illegal characters in Name Objects ## Version 1.19, 2013-10-08 BUGFIXES: - Removed pop in sweepIndirectReferences to prevent infinite loop (provided by ian-su-sirca) - Fixed bug caused by whitespace when parsing PDFs generated by AutoCad - Fixed a bug caused by reading a 'null' ASCII value in a dictionary object (primarily in PDFs generated by AutoCad). FEATURES: - Added new folders for PyPDF2 sample code and example PDFs; see README for each folder - Added a method for debugging purposes to show current location while parsing - Ability to create custom metadata (by jamma313) - Ability to access and customize document layout and view mode (by Joshua Arnott) OTHER: - Added and corrected some documentation - Added some more warnings and exception messages - Removed old test/debugging code UPCOMING: - More bugfixes (We have received many problematic PDFs via email, we will work with them) - Documentation - It's time for PyPDF2 to get its own documentation since it has grown much since the original pyPdf - A FAQ to answer common questions ## Version 1.18, 2013-08-19 - Fixed a bug where older versions of objects were incorrectly added to the cache, resulting in outdated or missing pages, images, and other objects (from speedplane) - Fixed a bug in parsing the xref table where new xref values were overwritten; also cleaned up code (from speedplane) - New method mergeRotatedAroundPointPage which merges a page while rotating it around a point (from speedplane) - Updated Destination syntax to respect PDF 1.6 specifications (from jamma313) - Prevented infinite loop when a PdfFileReader object was instantiated with an empty file (from Jerome Nexedi) Other Changes: - Downloads now available via PyPI - Installation through pip library is fixed ## Version 1.17, 2013-07-25 - Removed one (from pdf.py) of the two Destination classes. Both classes had the same name, but were slightly different in content, causing some errors. (from Janne Vanhala) - Corrected and Expanded README file to demonstrate PdfFileMerger - Added filter for LZW encoded streams (from Michal Horejsek) - PyPDF2 issue tracker enabled on Github to allow community discussion and collaboration ## Versions -1.16, -2013-06-30 - Note: This ChangeLog has not been kept up-to-date for a while. Hopefully we can keep better track of it from now on. Some of the changes listed here come from previous versions 1.14 and 1.15; they were only vaguely defined. With the new _version.py file we should have more structured and better documented versioning from now on. - Defined `PyPDF2.__version__` - Fixed encrypt() method (from Martijn The) - Improved error handling on PDFs with truncated streams (from cecilkorik) - Python 3 support (from kushal-kumaran) - Fixed example code in README (from Jeremy Bethmont) - Fixed an bug caused by DecimalError Exception (from Adam Morris) - Many other bug fixes and features by: jeansch Anton Vlasenko Joseph Walton Jan Oliver Oelerich Fabian Henze And any others I missed. Thanks for contributing! ## Version 1.13, 2010-12-04 - Fixed a typo in code for reading a "\b" escape character in strings. - Improved `__repr__` in FloatObject. - Fixed a bug in reading octal escape sequences in strings. - Added getWidth and getHeight methods to the RectangleObject class. - Fixed compatibility warnings with Python 2.4 and 2.5. - Added addBlankPage and insertBlankPage methods on PdfFileWriter class. - Fixed a bug with circular references in page's object trees (typically annotations) that prevented correctly writing out a copy of those pages. - New merge page functions allow application of a transformation matrix. - To all patch contributors: I did a poor job of keeping this ChangeLog up-to-date for this release, so I am missing attributions here for any changes you submitted. Sorry! I'll do better in the future. ## Version 1.12, 2008-09-02 - Added support for XMP metadata. - Fix reading files with xref streams with multiple /Index values. - Fix extracting content streams that use graphics operators longer than 2 characters. Affects merging PDF files. ## Version 1.11, 2008-05-09 - Patch from Hartmut Goebel to permit RectangleObjects to accept NumberObject or FloatObject values. - PDF compatibility fixes. - Fix to read object xref stream in correct order. - Fix for comments inside content streams. ## Version 1.10, 2007-10-04 - Text strings from PDF files are returned as Unicode string objects when pyPdf determines that they can be decoded (as UTF-16 strings, or as PDFDocEncoding strings). Unicode objects are also written out when necessary. This means that string objects in pyPdf can be either generic.ByteStringObject instances, or generic.TextStringObject instances. - The extractText method now returns a unicode string object. - All document information properties now return unicode string objects. In the event that a document provides docinfo properties that are not decoded by pyPdf, the raw byte strings can be accessed with an "_raw" property (ie. title_raw rather than title) - generic.DictionaryObject instances have been enhanced to be easier to use. Values coming out of dictionary objects will automatically be de-referenced (.getObject will be called on them), unless accessed by the new "raw_get" method. DictionaryObjects can now only contain PdfObject instances (as keys and values), making it easier to debug where non-PdfObject values (which cannot be written out) are entering dictionaries. - Support for reading named destinations and outlines in PDF files. Original patch by Ashish Kulkarni. - Stream compatibility reading enhancements for malformed PDF files. - Cross reference table reading enhancements for malformed PDF files. - Encryption documentation. - Replace some "assert" statements with error raising. - Minor optimizations to FlateDecode algorithm increase speed when using PNG predictors. ## Version 1.9, 2006-12-15 - Fix several serious bugs introduced in version 1.8, caused by a failure to run through our PDF test suite before releasing that version. - Fix bug in NullObject reading and writing. ## Version 1.8, 2006-12-14 - Add support for decryption with the standard PDF security handler. This allows for decrypting PDF files given the proper user or owner password. - Add support for encryption with the standard PDF security handler. - Add new pythondoc documentation. - Fix bug in ASCII85 decode that occurs when whitespace exists inside the two terminating characters of the stream. ## Version 1.7, 2006-12-10 - Fix a bug when using a single page object in two PdfFileWriter objects. - Adjust PyPDF to be tolerant of whitespace characters that don't belong during a stream object. - Add documentInfo property to PdfFileReader. - Add numPages property to PdfFileReader. - Add pages property to PdfFileReader. - Add extractText function to PdfFileReader. ## Version 1.6, 2006-06-06 - Add basic support for comments in PDF files. This allows us to read some ReportLab PDFs that could not be read before. - Add "auto-repair" for finding xref table at slightly bad locations. - New StreamObject backend, cleaner and more powerful. Allows the use of stream filters more easily, including compressed streams. - Add a graphics state push/pop around page merges. Improves quality of page merges when one page's content stream leaves the graphics in an abnormal state. - Add PageObject.compressContentStreams function, which filters all content streams and compresses them. This will reduce the size of PDF pages, especially after they could have been decompressed in a mergePage operation. - Support inline images in PDF content streams. - Add support for using .NET framework compression when zlib is not available. This does not make pyPdf compatible with IronPython, but it is a first step. - Add support for reading the document information dictionary, and extracting title, author, subject, producer and creator tags. - Add patch to support NullObject and multiple xref streams, from Bradley Lawrence. ## Version 1.5, 2006-01-28 - Fix a bug where merging pages did not work in "no-rename" cases when the second page has an array of content streams. - Remove some debugging output that should not have been present. ## Version 1.4, 2006-01-27 - Add capability to merge pages from multiple PDF files into a single page using the PageObject.mergePage function. See example code (README or web site) for more information. - Add ability to modify a page's MediaBox, CropBox, BleedBox, TrimBox, and ArtBox properties through PageObject. See example code (README or web site) for more information. - Refactor pdf.py into multiple files: generic.py (contains objects like NameObject, DictionaryObject), filters.py (contains filter code), utils.py (various). This does not affect importing PdfFileReader or PdfFileWriter. - Add new decoding functions for standard PDF filters ASCIIHexDecode and ASCII85Decode. - Change url and download_url to refer to new pybrary.net web site. ## Version 1.3, 2006-01-23 - Fix new bug introduced in 1.2 where PDF files with \r line endings did not work properly anymore. A new test suite developed with various PDF files should prevent regression bugs from now on. - Fix a bug where inheriting attributes from page nodes did not work. ## Version 1.2, 2006-01-23 - Improved support for files with CRLF-based line endings, fixing a common reported problem stating "assertion error: assert line == "%%EOF"". - Software author/maintainer is now officially a proud married person, which is sure to result in better software... somehow. ## Version 1.1, 2006-01-18 - Add capability to rotate pages. - Improved PDF reading support to properly manage inherited attributes from /Type=/Pages nodes. This means that page groups that are rotated or have different media boxes or whatever will now work properly. - Added PDF 1.5 support. Namely cross-reference streams and object streams. This release can mangle Adobe's PDFReference16.pdf successfully. ## Version 1.0, 2006-01-17 - First distutils-capable true public release. Supports a wide variety of PDF files that I found sitting around on my system. - Does not support some PDF 1.5 features, such as object streams, cross-reference streams. pypdf-6.1.2/docs/meta/comparisons.md000066400000000000000000000072421507516550200174120ustar00rootroot00000000000000# pypdf vs X pypdf is a [free] and open source pure-python PDF library capable of splitting, merging, cropping, and transforming the pages of PDF files. It can also add custom data, viewing options, and passwords to PDF files. pypdf can retrieve text and metadata from PDFs as well. ## PyMuPDF and PikePDF [PyMuPDF] is a Python binding to [MuPDF] and [PikePDF] is the Python binding to [QPDF]. While both are excellent libraries for various use-cases, using them is not always possible even when they support the use-case. Both of them are powered by C libraries which make installation harder and might cause security concerns. For MuPDF, you might also need to buy a commercial license. A core feature of pypdf is that it's pure Python. That means there is no C dependency. It has been used for over 10 years and for this reason a lot of support via StackOverflow and examples on the internet. ## pypdf PyPDF2 was merged back into `pypdf`. The development continues at `pypdf`. ## PyPDF3 and PyPDF4 Developing and maintaining open source software is extremely time-intensive and in the case of pypdf not paid at all. Having continuous support is hard. pypdf was initially released in 2012 on PyPI and received releases until 2016. From 2016 to 2022, there was no update - but people were still using it. As pypdf is free software, there were attempts to fork it and continue the development. PyPDF3 was first released in 2018 and still receives updates. PyPDF4 has only one release from 2018. Martin Thoma has worked on bringing the community back to one path of development. He deprecated PyPDF2 in favor of pypdf already, and pypdf has more features and a cleaner interface than PyPDF2 now. See [history of pypdf](history.md). [free]: https://en.wikipedia.org/wiki/Free_software [PyMuPDF]: https://pypi.org/project/PyMuPDF/ [MuPDF]: https://mupdf.com/ [PikePDF]: https://pypi.org/project/pikepdf/ [QPDF]: https://github.com/qpdf/qpdf ## pdfminer.six and pdfplumber [`pdfminer.six`](https://pypi.org/project/pdfminer.six/) is capable of extracting the [font size](https://stackoverflow.com/a/69962459/562769) / font weight (bold-ness). It has no capabilities for writing PDF files. [`pdfplumber`](https://pypi.org/project/pdfplumber/) is a library focused on extracting data from PDF documents. Since `pdfplumber` is built on top of `pdfminer.six`, there are **no capabilities of exporting or modifying a PDF file** (see [#440 (discussions)](https://github.com/jsvine/pdfplumber/discussions/440#discussioncomment-803880)). However, `pdfplumber` is capable of converting a PDF file into an image, [draw lines and rectangles on the image](https://github.com/jsvine/pdfplumber#drawing-methods), and save it as an image file. Please note that the image conversion is done via ImageMagick (see [`pdfplumber`'s documentation](https://github.com/jsvine/pdfplumber#visual-debugging)). The `pdfplumber` community is active in answering questions and the library is maintained as of May 2023. ## pdfrw / pdfrw2 I don't have experience with any of those libraries. Please add a comparison if you know pypdf and [`pdfrw`](https://pypi.org/project/pdfrw/)! Please be aware that there is also [`pdfminer`](https://pypi.org/project/pdfminer/) which is not maintained. Then there is [`pdfrw2`](https://pypi.org/project/pdfrw2/) which doesn't have a large community behind it. ## Document Generation There are (Python) [tools to generate PDF documents](https://github.com/py-pdf/awesome-pdf#generators). pypdf is not one of them. ## CLI applications pypdf is a pure Python PDF library. If you're looking for an application which you can use from the terminal, give [`pdfly`](https://pdfly.readthedocs.io/en/latest/) a shot. pypdf-6.1.2/docs/meta/faq.md000066400000000000000000000056021507516550200156220ustar00rootroot00000000000000# Frequently Asked Questions ## How is pypdf related to PyPDF2? PyPDF2 was a fork from the original pyPdf. After several years, the fork was merged back into `pypdf` (now all lowercase). ## Which Python versions are supported? pypdf 3.0+ supports Python 3.6 and later. PyPDF2 2.0+ supports Python 3.6 and later. PyPDF2 1.27.10 supported Python 2.7 to 3.10. [Matthew]: https://github.com/mstamy2 [source]: https://github.com/py-pdf/PyPDF2/commit/24b270d876518d15773224b5d0d6c2206db29f64#commitcomment-5038317 [this sort of thing]: https://github.com/py-pdf/PyPDF2/issues/24 [GitHub issue]: https://github.com/py-pdf/PyPDF2/issues ## Who uses pypdf? pyPdf is vendored [into](https://github.com/Buyanbat/XacCRM/tree/ee78e8df967182f661b6494a86444501e7d89c8f/report/pyPdf) [several](https://github.com/MyBook/calibre/tree/ca1efe3c21f6553e096dab745b3cdeb36244a5a9/src/pyPdf) [projects](https://github.com/Giacomo-De-Florio-Dev/Make_Your_PDF_Safe/tree/ec439f92243d12d54ae024668792470c6b40ee96/MakeYourPDFsafe_V1.3/PyPDF2). That means the code of pyPdf was copied into that project. Projects that depend on pypdf: * [Camelot](https://github.com/camelot-dev/camelot): A Python library to extract tabular data from PDFs * [edi](https://github.com/OCA/edi): Electronic Data Interchange modules * [amazon-textract-textractor](https://github.com/aws-samples/amazon-textract-textractor/blob/42444b08c672607eadbdcd64f3c5adb2d85383de/helper/setup.py): Analyze documents with Amazon Textract and generate output in multiple formats. * [maigret](https://github.com/soxoj/maigret): Collect a dossier on a person by username from thousands of sites * [deda](https://github.com/dfd-tud/deda): tracking Dots Extraction, Decoding and Anonymisation toolkit * [opencanary](https://github.com/thinkst/opencanary) * Document Conversions * [rst2pdf](https://github.com/rst2pdf/rst2pdf) * [xhtml2pdf](https://github.com/xhtml2pdf/xhtml2pdf) * [doc2text](https://github.com/jlsutherland/doc2text) * [pdfalyzer](https://pypi.org/project/pdfalyzer/): A PDF analysis tool for visualizing the inner tree-like data structure of a PDF in spectacularly large and colorful diagrams as well as scanning the binary streams embedded in the PDF for hidden potentially malicious content. ## How do I cite pypdf? In BibTeX format: ``` @misc{pypdf, title = {The {pypdf} library}, author = {Mathieu Fenniak and Matthew Stamy and pubpub-zz and Martin Thoma and Matthew Peveler and exiledkingcc and {pypdf Contributors}}, year = {2024}, url = {https://pypi.org/project/pypdf/} note = {See https://pypdf.readthedocs.io/en/latest/meta/CONTRIBUTORS.html for all contributors} } ``` ## Which License does pypdf use? `pypdf` uses the [BSD-3-Clause license](https://en.wikipedia.org/wiki/BSD_licenses#3-clause), see the LICENSE file. pypdf-6.1.2/docs/meta/history.md000066400000000000000000000067131507516550200165600ustar00rootroot00000000000000# History of pypdf ## The Origins: pyPdf (2005-2010) In 2005, [Mathieu Fenniak] launched pyPdf "as a PDF toolkit..." focused on - document manipulation: by-page splitting, concatenation, and merging; - document introspection; - page cropping; and - document encryption and decryption. The last release of PyPI was [pyPdf 1.13](https://pypi.org/project/pyPdf/#history) in 2010. ## PyPDF2 is born (2011-2016) At the end of 2011, after consultation with Mathieu and others, Phaseit sponsored PyPDF2 as a fork of pyPdf on GitHub. The initial impetus was to handle a wider range of input PDF instances; Phaseit\'s commercial work often encounters PDF instances \"in the wild\" that it needs to manage (mostly concatenate and paginate), but that deviates so much from PDF standards that pyPdf can't read them. PyPDF2 reads a considerably wider range of real-world PDF instances. Neither pyPdf nor PyPDF2 aims to be universal, that is, to provide all possible PDF-related functionality. Note that the similar-appearing [pyfpdf] of Mariano Reingart is most comparable to [ReportLab], in that both ReportLab and pyfpdf emphasize document generation. Interestingly enough, pyfpdf builds in a basic HTML→PDF converter while PyPDF2 has no knowledge of HTML. So what is PyPDF2 truly about? Think about popular [pdftk] for a moment. PyPDF2 does what pdftk does, and it does so within your current Python process, and it handles a wider range of variant PDF formats \[explain\]. PyPDF2 has its own FAQ to answer other questions that have arisen. The Reddit [/r/python crowd chatted] obliquely and briefly about PyPDF2 in March 2012. The core developer / maintainer was Matthew Stamy. ## PyPDF3 and PyPDF4 (2018-2022) Two approaches were made to get PyPDF2 active again: PyPDF3 and PyPDF4. PyPDF3 had its first release in 2018 and its last one in February 2022. It never got the user base from PyPDF2. PyPDF4 only had one release in 2018. ## PyPDF2: Reborn (2022) Martin Thoma took over maintenance of PyPDF2 in April 2022. It had over 100 open PRs and 321 open issues. [pubpub-zz](https://github.com/pubpub-zz) was extremely active, especially for text extraction. [Matthew Peveler](https://github.com/MasterOdin) helped a lot with reviews and general project decisions. [exiledkingcc](https://github.com/exiledkingcc) added support for modern encryption schemes. ## pypdf: Back to the Roots (2023-2024) In order to simplify things for beginners, PyPDF2 was merged back into pypdf. Now all lowercase, without a number. We hope that the folks who develop PyPDF3 and PyPDF4 also join us. Compared to `PyPDF2 >= 3.0.0`, `pypdf >= 3.1.0` now offers: * AES reading and writing support. Not only with PyCryptoDome, but also with cryptography. * Text extraction improvements, e.g., for math content. [pypdf is now comparable with Tika, pypdfium2, and PyMuPDF](https://github.com/py-pdf/benchmarks) * Annotation support * Performance Improvements and Bugfixes * Page Label support stefan6419846 made his [first PR for pypdf](https://github.com/py-pdf/pypdf/pull/2022) in July 2023 and joined the project. [Mathieu Fenniak]: https://mathieu.fenniak.net/ [pyfpdf]: https://github.com/reingart/pyfpdf [ReportLab]: https://www.reportlab.com/software/opensource/rl-toolkit/ [pdftk]: https://www.pdflabs.com/tools/pdftk-the-pdf-toolkit/https://www.pdflabs.com/tools/pdftk-the-pdf-toolkit/ [/r/python crowd chatted]: https://www.reddit.com/r/Python/comments/qsvfm/pypdf2_updates_pypdf_pypdf2_is_an_opensource/ pypdf-6.1.2/docs/meta/project-governance.md000066400000000000000000000163421507516550200206510ustar00rootroot00000000000000# Project Governance This document describes how the pypdf project is managed. It describes the different actors, their roles, and the responsibilities they have. ## Terminology * The **project** is pypdf - a free and open-source pure-python PDF library capable of splitting, merging, cropping, and transforming the pages of PDF files. It includes the [code, issues, and discussions on GitHub](https://github.com/py-pdf/pypdf), and [the documentation on ReadTheDocs](https://pypdf.readthedocs.io/en/latest/), [the package on PyPI](https://pypi.org/project/pypdf/), and [the website on GitHub](https://py-pdf.github.io/pypdf/dev/bench/). * A **maintainer** is a person who has technical permissions to change one or more parts of the projects. It is a person driven to keep the project running and improving. * A **contributor** is a person who contributes to the project. That could be through writing code - in the best case through forking and creating a pull request, but that is up to the maintainer. Other contributors describe issues, help to ask questions on existing issues to make them easier to answer, participate in discussions, and help to improve the documentation. Contributors are similar to maintainers, but without technical permissions. * A **user** is a person who imports pypdf into their code. All pypdf users are developers, but not developers who know the internals of pypdf. They only use the public interface of pypdf. They will likely have less knowledge about PDF than contributors. * The **community** is all of that - the users, the contributors, and the maintainers. ## Governance, Leadership, and Steering pypdf forward pypdf is a free and open source project with over 100 contributors and likely (way) more than 1000 users. As pypdf does not have any formal relationship with any company and no funding, all the work done by the community are voluntary contributions. People don't get paid, but choose to spend their free time to create software of which many more are profiting. This has to be honored and respected. Despite such a big community, the project was dormant from 2016 to 2022. There were still questions asked, issues reported, and pull requests created. But the maintainer didn't have the time to move pypdf forward. During that time, nobody else stepped up to become the new maintainer. For this reason, pypdf has the **Benevolent Dictator** governance model. The benevolent dictator is a maintainer with all technical permissions - most importantly the permission to push new pypdf versions on PyPI. Being benevolent, the benevolent dictator listens for decisions to the community and tries their best to make decisions from which the overall community profits - the current one and the potential future one. Being a dictator, the benevolent dictator always has the power and the right to make decisions on their own - also against some members of the community. As pypdf is free software, parts of the community can split off (fork the code) and create a new community. This should limit the harm a bad benevolent dictator can do. ## Project Language The project language is (american) English. All documentation and issues must be written in English to ensure that the community can understand it. We appreciate the fact that large parts of the community don't have English as their native language. We try our best to understand others - [automatic translators](https://translate.google.com/) might help. ## Expectations The community can expect the following: * The **benevolent dictator** tries their best to make decisions from which the overall community profits. The benevolent dictator is aware that his/her decisions can shape the overall community. Once the benevolent dictator notices that she/he doesn't have the time to advance pypdf, he/she looks for a new benevolent dictator. As it is expected that the benevolent dictator will step down at some point of their choice (hopefully before their death), it is NOT a benevolent dictator for life (BDFL). * Every **maintainer** (including the benevolent dictator) is aware of their permissions and the harm they could do. They value security and ensure that the project is not harmed. They give their technical permissions back if they don't need them any longer. Any long-time contributor can become a maintainer. Maintainers can - and should! - step down from their role when they realize that they can no longer commit that time. Their contribution will be honored in the {doc}`history`. * Every **contributor** is aware that the time of maintainers and the benevolent dictator is limited. Short pull requests that briefly describe the solved issue and have a unit test have a higher chance to get merged soon - simply because it's easier for maintainers to see that the contribution will not harm the overall project. Their contributions are documented in the git history and in the public issues. [Let us know](https://github.com/py-pdf/pypdf/discussions/798) if you would appreciate something else! * Every **community member** uses a respectful language. We are all human, we get upset about things we care and other things than what's visible on the internet go on in our live. pypdf does not pay its contributors - keep all of that in mind when you interact with others. We are here because we want to help others. ### Issues and Discussions An issue is any technical description that aims at bringing pypdf forward: * Bugs tickets: Something went wrong because pypdf developers made a mistake. * Feature requests: pypdf does not support all features of the PDF specifications. There are certainly also convenience methods that would help users a lot. * Robustness requests: There are many broken PDFs around. In some cases, we can deal with that. It's kind of a mixture between a bug ticket and a feature request. * Performance tickets: pypdf could be faster - let us know about your specific scenario. Any comment that is in those technical descriptions which is not helping the discussion can be deleted. This is especially true for "me too" comments on bugs or "bump" comments for desired features. People can express this with đź‘Ť / đź‘Ž reactions. [Discussions](https://github.com/py-pdf/pypdf/discussions) are open. No comments will be deleted there - except if they are unrelated spam or only try to insult people (luckily, the community was very respectful so far 🤞) ### Releases The maintainers follow [semantic versioning](https://semver.org/). Most importantly, that means that breaking changes will have a major version bump. Be aware that unintentional breaking changes might still happen. The pypdf maintainers do their best to fix that in a timely manner - please [report such issues](https://github.com/py-pdf/pypdf/issues)! ## People * [stefan6419846](https://github.com/stefan6419846) is the benevolent dictator since January 2025 * [Martin Thoma](https://github.com/MartinThoma) was the benevolent dictator from April 2022 to January 2025. He still has most of the permissions as a fallback. * Maintainers: * Matthew Stamy (mstamy2) was the benevolent dictator for a long time. He still is around on GitHub once in a while and has permissions on PyPI and GitHub. * Matthew Peveler (MasterOdin) is a maintainer on GitHub. pypdf-6.1.2/docs/meta/scope-of-pypdf.md000066400000000000000000000104521507516550200177050ustar00rootroot00000000000000# Scope of pypdf What features should pypdf have and which features will it never have? pypdf aims at simplifying interactions with PDF documents. Core tasks that pypdf can perform are: * Document manipulation: Splitting, merging, cropping, and transforming the pages of PDF files * Data Extraction: Extract text and metadata from PDF documents * Security: Decrypt / encrypt PDF documents Typical indicators that pypdf should do something: * The task needs in-depth knowledge of the PDF format * It currently requires a lot of code or even is impossible to do with pypdf * It's neither mentioned in "belongs in user code" nor in "out of scope" * It already is in the issue list with the [is-feature tag](https://github.com/py-pdf/pypdf/labels/is-feature). The [moonshot extensions](https://github.com/py-pdf/pypdf/discussions/1181) are features we would like to have, but are currently not able to add (PRs are welcome đź‰) ## Belongs in user code Here are a few indicators that a feature belongs into users' code (and not into pypdf): 1. The use-case is very specific. Most people will not encounter the same need. 2. It can be done without knowledge of the PDF specification 3. It cannot be done without (non-pdf) domain knowledge. Anything that is specific to your industry. ## Out of scope While this list is infinitely long, there are a few topics that are asked multiple times. Those topics are out of scope for pypdf. They will never be part of pypdf: 1. **Optical Character Recognition (OCR)**: OCR is about extracting text from images. That is very different from the kind of text extraction pypdf is doing. Please note that images can be within PDF documents. In the case of scanned documents, the whole page is an image. Some scanners automatically execute OCR and add a text-layer behind the scanned page. That is something pypdf can use if it's present. As a rule-of-thumb: If you cannot mark/copy the text, it's likely an image. A noteworthy open source OCR project is [tesseract](https://github.com/tesseract-ocr/tesseract). 2. **Format Conversion**: Converting docx / HTML to PDF or PDF to those formats. You might want to have a look at [`pdfkit`](https://pypi.org/project/pdfkit/) and similar projects. Out of scope for the moment, but might be added if there are enough contributors: * **Digital Signature Support** ([reference ticket](https://github.com/py-pdf/pypdf/issues/302)): Cryptography is complicated. It's important to get it right. pypdf currently doesn't have enough active contributors to properly add digital signature support. For the moment, [pyhanko](https://pypi.org/project/pyHanko/) seems to be the best choice. * **PDF Generation from Scratch**: pypdf can manipulate existing PDF documents, add annotations, combine / split / crop / transform. It can add blank pages. But if you want to generate invoices, you might want to have a look at [`reportlab`](https://pypi.org/project/reportlab/) / [`fpdf2`](https://pypi.org/project/fpdf2/) or document conversion tools like [`pdfkit`](https://pypi.org/project/pdfkit/). * **Replacing words within a PDF**: [Extracting text from PDF is hard](../user/extract-text.md#why-text-extraction-is-hard). Replacing text in a reliable way is even harder. For example, one word might be split into multiple tokens. Hence, it's not a simple "search and replace" in some cases. * **(Not) Extracting headers/footers/page numbers**: While you can apply heuristics, there is no way to always make it work. PDF documents simply don't contain the information what a header/footer/page number is. ### Library vs. Application It's also worth pointing out that `pypdf` is designed to be a library. It is not an application. That has several implications: * Execution: pypdf cannot be executed directly, but only be called from within a program written by a pypdf user. In contrast, an application is executed on its own. * Dependencies: pypdf should have a minimal set of dependencies and only restrict them where it is strictly necessary. In contrast, applications should be installed in environments which are isolated from other applications. They can pin their dependencies. If you're looking for a way to interact with PDF files via Shell, you should either write a script using pypdf or use [`pdfly`](https://pypi.org/project/pdfly/). pypdf-6.1.2/docs/meta/taking-ownership.md000066400000000000000000000036621507516550200203500ustar00rootroot00000000000000# Taking Ownership of pypdf pypdf is currently maintained by stefan6419846. We want to avoid that pypdf ever goes unmaintained again. This document serves as a guide to avoid that if I become unavailable, e.g., due to severe health issues. This currently is just an abstract scenario. I'm fine, and I will likely do this for several more years, but I have seen how projects stand still for many years because of the maintainer becoming inactive. ## What belongs to pypdf? The resources needed for maintaining pypdf are: * PyPI: [pypdf](https://pypi.org/project/pypdf/) and [PyPDF2](https://pypi.org/project/PyPDF2/) * GitHub: [pypdf](https://github.com/py-pdf/pypdf) (the repository, not the organization) * ReadTheDocs: [pypdf](https://readthedocs.org/projects/pypdf/) and [PyPDF2](https://readthedocs.org/projects/pypdf2/) ## When may somebody take ownership? **No activity in 180 days**: If I don't answer e-mails (see my GitHub profile) and don't make any commits / merges for half a year, you can consider pypdf "not maintained." ## Who may take ownership? Preferably, one of the owners of the GitHub `py-pdf` organization takes care of that. As of 27th of August 2023, the following people might be candidates: * [Lucas-C](https://github.com/Lucas-C): He maintains fpdf2 and is a py-pdf owner * [pubpub-zz](https://github.com/pubpub-zz): He is one of the most active contributors to pypdf * [Matthew Peveler](https://github.com/MasterOdin): Less active, but he is cautious about breaking changes and an experienced software developer. * [exiledkingcc](https://github.com/exiledkingcc): He has contributed the core changes related to encryption. ## How to take ownership? * PyPI: Follow [PEP 541 – Package Index Name Retention](https://peps.python.org/pep-0541/) * GitHub: Talk with one of the other py-pdf organization owners * ReadTheDocs: Follow the [Abandoned projects policy](https://docs.readthedocs.io/en/latest/abandoned-projects.html) pypdf-6.1.2/docs/modules/000077500000000000000000000000001507516550200152505ustar00rootroot00000000000000pypdf-6.1.2/docs/modules/Destination.rst000066400000000000000000000002171507516550200202630ustar00rootroot00000000000000The Destination Class --------------------- .. autoclass:: pypdf.generic.Destination :members: :undoc-members: :show-inheritance: pypdf-6.1.2/docs/modules/DocumentInformation.rst000066400000000000000000000002371507516550200217700ustar00rootroot00000000000000The DocumentInformation Class ----------------------------- .. autoclass:: pypdf.DocumentInformation :members: :undoc-members: :show-inheritance: pypdf-6.1.2/docs/modules/Field.rst000066400000000000000000000001751507516550200170300ustar00rootroot00000000000000The Field Class --------------- .. autoclass:: pypdf.generic.Field :members: :undoc-members: :show-inheritance: pypdf-6.1.2/docs/modules/Fit.rst000066400000000000000000000001671507516550200165300ustar00rootroot00000000000000The Fit Class ------------- .. autoclass:: pypdf.generic.Fit :members: :undoc-members: :show-inheritance: pypdf-6.1.2/docs/modules/PageObject.rst000066400000000000000000000005641507516550200200120ustar00rootroot00000000000000The PageObject Class -------------------- .. autoclass:: pypdf._page.PageObject :members: :undoc-members: :show-inheritance: .. autoclass:: pypdf._page.VirtualListImages :members: :undoc-members: :show-inheritance: .. autoclass:: pypdf._page.ImageFile :members: :inherited-members: File :undoc-members: .. autofunction:: pypdf.mult pypdf-6.1.2/docs/modules/PageRange.rst000066400000000000000000000002011507516550200176240ustar00rootroot00000000000000The PageRange Class ------------------- .. autoclass:: pypdf.PageRange :members: :undoc-members: :show-inheritance: pypdf-6.1.2/docs/modules/PaperSize.rst000066400000000000000000000015011507516550200177010ustar00rootroot00000000000000The PaperSize Class ------------------- .. autoclass:: pypdf.PaperSize :members: :undoc-members: :show-inheritance: Add blank page with PaperSize ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ .. code-block:: python :linenos: from pypdf import PaperSize, PdfWriter writer = PdfWriter(clone_from="sample.pdf") writer.add_blank_page(PaperSize.A8.width, PaperSize.A8.height) with open("output.pdf", "wb") as output_stream: writer.write(output_stream) Insert blank page with PaperSize ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ .. code-block:: python :linenos: from pypdf import PaperSize, PdfWriter writer = PdfWriter(clone_from="sample.pdf") writer.insert_blank_page(PaperSize.A8.width, PaperSize.A8.height, 1) with open("output.pdf", "wb") as output_stream: writer.write(output_stream) pypdf-6.1.2/docs/modules/PdfDocCommon.rst000066400000000000000000000005501507516550200203120ustar00rootroot00000000000000The PdfDocCommon Class ---------------------- **PdfDocCommon** is an abstract class which is inherited by :class:`~pypdf.PdfReader` and :class:`~pypdf.PdfWriter`. Where identified in the API, you can use any of the derived class. .. autoclass:: pypdf._doc_common.PdfDocCommon :members: :inherited-members: :undoc-members: :show-inheritance: pypdf-6.1.2/docs/modules/PdfReader.rst000066400000000000000000000003651507516550200176420ustar00rootroot00000000000000The PdfReader Class ------------------- .. autoclass:: pypdf.PdfReader :members: :inherited-members: :undoc-members: :show-inheritance: .. autoclass:: pypdf.PasswordType :members: :undoc-members: :show-inheritance: pypdf-6.1.2/docs/modules/PdfWriter.rst000066400000000000000000000003731507516550200177130ustar00rootroot00000000000000The PdfWriter Class ------------------- .. autoclass:: pypdf.PdfWriter :members: :inherited-members: :undoc-members: :show-inheritance: .. autoclass:: pypdf.ObjectDeletionFlag :members: :undoc-members: :show-inheritance: pypdf-6.1.2/docs/modules/RectangleObject.rst000066400000000000000000000002331507516550200210330ustar00rootroot00000000000000The RectangleObject Class ------------------------- .. autoclass:: pypdf.generic.RectangleObject :members: :undoc-members: :show-inheritance: pypdf-6.1.2/docs/modules/Transformation.rst000066400000000000000000000002201507516550200210020ustar00rootroot00000000000000The Transformation Class ------------------------ .. autoclass:: pypdf.Transformation :members: :undoc-members: :show-inheritance: pypdf-6.1.2/docs/modules/XmpInformation.rst000066400000000000000000000002251507516550200207530ustar00rootroot00000000000000The XmpInformation Class ------------------------- .. autoclass:: pypdf.xmp.XmpInformation :members: :undoc-members: :show-inheritance: pypdf-6.1.2/docs/modules/annotations.rst000066400000000000000000000002121507516550200203320ustar00rootroot00000000000000The annotations module ---------------------- .. automodule:: pypdf.annotations :members: :undoc-members: :show-inheritance: pypdf-6.1.2/docs/modules/constants.rst000066400000000000000000000012241507516550200200150ustar00rootroot00000000000000Constants --------- .. autoclass:: pypdf.constants.AnnotationFlag :members: :undoc-members: :show-inheritance: .. autoclass:: pypdf.constants.ImageType :members: :undoc-members: :show-inheritance: .. autoclass:: pypdf.constants.PageLabelStyle :members: :undoc-members: :show-inheritance: .. autoclass:: pypdf.constants.UserAccessPermissions :members: :undoc-members: :show-inheritance: .. autoclass:: pypdf.constants.FieldDictionaryAttributes :members: :undoc-members: :exclude-members: FT, Parent, Kids, T, TU, TM, V, DV, AA, Opt, attributes, attributes_dict :show-inheritance: pypdf-6.1.2/docs/modules/errors.rst000066400000000000000000000001451507516550200173160ustar00rootroot00000000000000Errors ------ .. automodule:: pypdf.errors :members: :undoc-members: :show-inheritance: pypdf-6.1.2/docs/modules/generic.rst000066400000000000000000000013611507516550200174170ustar00rootroot00000000000000Generic PDF objects ------------------- .. automodule:: pypdf.generic :members: :undoc-members: :show-inheritance: :exclude-members: Destination, Field, Fit, RectangleObject .. autoclass:: pypdf._protocols.PdfObjectProtocol :members: :undoc-members: :show-inheritance: .. autoclass:: pypdf._protocols.XmpInformationProtocol :members: :undoc-members: :show-inheritance: .. autoclass:: pypdf._protocols.PdfCommonDocProtocol :members: :undoc-members: :show-inheritance: .. autoclass:: pypdf._protocols.PdfReaderProtocol :members: :undoc-members: :show-inheritance: .. autoclass:: pypdf._protocols.PdfWriterProtocol :members: :undoc-members: :show-inheritance: pypdf-6.1.2/docs/user/000077500000000000000000000000001507516550200145565ustar00rootroot00000000000000pypdf-6.1.2/docs/user/add-javascript.md000066400000000000000000000012521507516550200177740ustar00rootroot00000000000000# Adding JavaScript to a PDF PDF readers vary in the extent they support JavaScript, with some not supporting it at all. Adobe has documentation on its support here: [https://opensource.adobe.com/dc-acrobat-sdk-docs/library/jsapiref/index.html](https://opensource.adobe.com/dc-acrobat-sdk-docs/library/jsapiref/index.html) ## Launch print window on opening ```python from pypdf import PdfWriter writer = PdfWriter(clone_from="example.pdf") # Add JavaScript to launch the print window on opening this PDF. writer.add_js("this.print({bUI:true,bSilent:false,bShrinkToFit:true});") # Write to pypdf-output.pdf. with open("pypdf-output.pdf", "wb") as fp: writer.write(fp) ``` pypdf-6.1.2/docs/user/add-watermark.md000066400000000000000000000063561507516550200176350ustar00rootroot00000000000000# Adding a Stamp or Watermark to a PDF Adding stamps or watermarks are two common ways to manipulate PDF files. A stamp is adding something on top of the document, a watermark is in the background of the document. ## Stamp (Overlay) / Watermark (Underlay) The process of stamping and watermarking is the same, you just need to set `over` parameter to `True` for stamping and `False` for watermarking. You can use {func}`~pypdf._page.PageObject.merge_page` if you don't need to transform the stamp: ```python from pypdf import PdfReader, PdfWriter stamp = PdfReader("bg.pdf").pages[0] writer = PdfWriter(clone_from="source.pdf") for page in writer.pages: page.merge_page(stamp, over=False) # here set to False for watermarking writer.write("out.pdf") ``` Otherwise use {func}`~pypdf._page.PageObject.merge_transformed_page` with {class}`~pypdf.Transformation` if you need to translate, rotate, scale, etc. the stamp before merging it to the content page. ```python from pathlib import Path from typing import List, Union from pypdf import PdfReader, PdfWriter, Transformation def stamp( content_pdf: Union[Path, str], stamp_pdf: Union[Path, str], pdf_result: Union[Path, str], page_indices: Union[None, List[int]] = None, ): stamp_page = PdfReader(stamp_pdf).pages[0] writer = PdfWriter() # page_indices can be a List(array) of page, tuples are for range definition reader = PdfReader(content_pdf) writer.append(reader, pages=page_indices) for content_page in writer.pages: content_page.merge_transformed_page( stamp_page, Transformation().scale(0.5), ) writer.write(pdf_result) stamp("example.pdf", "stamp.pdf", "out.pdf") ``` If you are experiencing wrongly rotated watermarks/stamps, try to use {func}`~pypdf._page.PageObject.transfer_rotation_to_content` on the corresponding pages beforehand to fix the page boxes. Example of stamp: ![stamp.png](stamp.png) Example of watermark: ![watermark.png](watermark.png) ## Stamping images directly The above code only works for stamps that are already in PDF format. However, you can easily convert an image to PDF image using [Pillow](https://pypi.org/project/Pillow/). ```python from io import BytesIO from pathlib import Path from typing import List, Union from PIL import Image from pypdf import PageRange, PdfReader, PdfWriter, Transformation def image_to_pdf(stamp_img: Union[Path, str]) -> PdfReader: img = Image.open(stamp_img) img_as_pdf = BytesIO() img.save(img_as_pdf, "pdf") return PdfReader(img_as_pdf) def stamp_img( content_pdf: Union[Path, str], stamp_img: Union[Path, str], pdf_result: Union[Path, str], page_indices: Union[PageRange, List[int], None] = None, ): # Convert the image to a PDF stamp_pdf = image_to_pdf(stamp_img) # Then use the same stamp code from above stamp_page = stamp_pdf.pages[0] writer = PdfWriter() reader = PdfReader(content_pdf) writer.append(reader, pages=page_indices) for content_page in writer.pages: content_page.merge_transformed_page( stamp_page, Transformation(), ) with open(pdf_result, "wb") as fp: writer.write(fp) stamp_img("example.pdf", "example.png", "out.pdf") ``` pypdf-6.1.2/docs/user/adding-pdf-annotations.md000066400000000000000000000204011507516550200214250ustar00rootroot00000000000000# Adding PDF Annotations ```{note} By default, some annotations might be invisible, for example polylines, as the default color is "transparent". To circumvent this, make sure to add the `/C` entry to the annotation, being an array and each array value being in the range 0.0 to 1.0: * With one element, a grayscale value. * With three elements, a RGB definition. * With four elements, a CMYK definition. ``` ## Attachments ```python from pypdf import PdfWriter writer = PdfWriter() writer.add_blank_page(width=200, height=200) data = b"any bytes - typically read from a file" writer.add_attachment("smile.png", data) with open("output.pdf", "wb") as output_stream: writer.write(output_stream) ``` ## Free Text If you want to add text in a box like this ![](free-text-annotation.png) you can use {class}`~pypdf.annotations.FreeText`: ```python from pypdf import PdfReader, PdfWriter from pypdf.annotations import FreeText # Fill the writer with the pages you want pdf_path = os.path.join(RESOURCE_ROOT, "crazyones.pdf") reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) # Create the annotation and add it annotation = FreeText( text="Hello World\nThis is the second line!", rect=(50, 550, 200, 650), font="Arial", bold=True, italic=True, font_size="20pt", font_color="00ff00", border_color="0000ff", background_color="cdcdcd", ) # Set annotation flags to 4 for printable annotations. # See "AnnotationFlag" for other options, e.g. hidden etc. annotation.flags = 4 writer.add_annotation(page_number=0, annotation=annotation) # Write the annotated file to disk with open("annotated-pdf.pdf", "wb") as fp: writer.write(fp) ``` ## Text A text annotation looks like this: ![](text-annotation.png) ## Line If you want to add a line like this: ![](annotation-line.png) you can use {class}`~pypdf.annotations.Line`: ```python from pypdf import PdfReader, PdfWriter from pypdf.annotations import Line pdf_path = os.path.join(RESOURCE_ROOT, "crazyones.pdf") reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) # Add the line annotation = Line( text="Hello World\nLine2", rect=(50, 550, 200, 650), p1=(50, 550), p2=(200, 650), ) writer.add_annotation(page_number=0, annotation=annotation) # Write the annotated file to disk with open("annotated-pdf.pdf", "wb") as fp: writer.write(fp) ``` ## PolyLine If you want to add a line like this: ![](annotation-polyline.png) you can use {class}`~pypdf.annotations.PolyLine`: ```python from pypdf import PdfReader, PdfWriter from pypdf.annotations import PolyLine from pypdf.generic import ArrayObject, FloatObject, NameObject pdf_path = os.path.join(RESOURCE_ROOT, "crazyones.pdf") reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) # Add the polyline # By default, the line will be transparent. Set an explicit color. annotation = PolyLine( vertices=[(50, 550), (200, 650), (70, 750), (50, 700)], ) annotation[NameObject("/C")] = ArrayObject( [FloatObject(0.9), FloatObject(0.1), FloatObject(0)] ) writer.add_annotation(page_number=0, annotation=annotation) # Write the annotated file to disk with open("annotated-pdf.pdf", "wb") as fp: writer.write(fp) ``` ## Rectangle If you want to add a rectangle like this: ![](annotation-square.png) you can use {class}`~pypdf.annotations.Rectangle`: ```python from pypdf import PdfReader, PdfWriter from pypdf.annotations import Rectangle pdf_path = os.path.join(RESOURCE_ROOT, "crazyones.pdf") reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) # Add the rectangle annotation = Rectangle( rect=(50, 550, 200, 650), ) writer.add_annotation(page_number=0, annotation=annotation) # Write the annotated file to disk with open("annotated-pdf.pdf", "wb") as fp: writer.write(fp) ``` If you want the rectangle to be filled, use the `interiour_color="ff0000"` parameter. This method uses the "square" annotation type of the PDF format. ## Ellipse If you want to add a circle like this: ![](annotation-circle.png) you can use {class}`~pypdf.annotations.Ellipse`: ```python from pypdf import PdfReader, PdfWriter from pypdf.annotations import Ellipse pdf_path = os.path.join(RESOURCE_ROOT, "crazyones.pdf") reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) # Add the rectangle annotation = Ellipse( rect=(50, 550, 200, 650), ) writer.add_annotation(page_number=0, annotation=annotation) # Write the annotated file to disk with open("annotated-pdf.pdf", "wb") as fp: writer.write(fp) ``` ## Polygon If you want to add a polygon like this: ![](annotation-polygon.png) you can use {class}`~pypdf.annotations.Polygon`: ```python from pypdf import PdfReader, PdfWriter from pypdf.annotations import Polygon pdf_path = os.path.join(RESOURCE_ROOT, "crazyones.pdf") reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) # Add the line annotation = Polygon( vertices=[(50, 550), (200, 650), (70, 750), (50, 700)], ) writer.add_annotation(page_number=0, annotation=annotation) # Write the annotated file to disk with open("annotated-pdf.pdf", "wb") as fp: writer.write(fp) ``` ## Popup Manage the Popup windows for markups, looks like this: ![](annotation-popup.png) you can use {py:class}`~pypdf.annotations.Popup`: ```python from pypdf.annotations import Popup, Text # Arrange writer = pypdf.PdfWriter() writer.append(os.path.join(RESOURCE_ROOT, "crazyones.pdf"), [0]) # Act text_annotation = writer.add_annotation( 0, Text( text="Hello World\nThis is the second line!", rect=(50, 550, 200, 650), open=True, ), ) popup_annotation = Popup( rect=(50, 550, 200, 650), open=True, parent=text_annotation, # use the output of add_annotation ) writer.write("annotated-pdf-popup.pdf") ``` You have to use the returned result from add_annotation() as it is the parent annotation with which this popup annotation shall be associated. ## Link If you want to add a link, you can use {class}`~pypdf.annotations.Link`: ```python from pypdf import PdfReader, PdfWriter from pypdf.annotations import Link pdf_path = os.path.join(RESOURCE_ROOT, "crazyones.pdf") reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) # Add the link annotation = Link( rect=(50, 550, 200, 650), url="https://martin-thoma.com/", ) writer.add_annotation(page_number=0, annotation=annotation) # Write the annotated file to disk with open("annotated-pdf.pdf", "wb") as fp: writer.write(fp) ``` You can also add internal links: ```python from pypdf import PdfReader, PdfWriter from pypdf.annotations import Link from pypdf.generic import Fit pdf_path = os.path.join(RESOURCE_ROOT, "crazyones.pdf") reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) # Add the link annotation = Link( rect=(50, 550, 200, 650), target_page_index=3, fit=Fit(fit_type="/FitH", fit_args=(123,)), ) writer.add_annotation(page_number=0, annotation=annotation) # Write the annotated file to disk with open("annotated-pdf.pdf", "wb") as fp: writer.write(fp) ``` ## Text Markup Annotations Text markup annotations refer to a specific piece of text within the document. These are a bit more complicated as you need to know exactly where the text is, the so-called "Quad points". ### Highlighting If you want to highlight text like this: ![](annotation-highlight.png) you can use {class}`~pypdf.annotations.Highlight`: ```python from pypdf import PdfReader, PdfWriter from pypdf.annotations import Highlight from pypdf.generic import ArrayObject, FloatObject pdf_path = os.path.join(RESOURCE_ROOT, "crazyones.pdf") reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) rect = (50, 550, 200, 650) quad_points = [rect[0], rect[1], rect[2], rect[1], rect[0], rect[3], rect[2], rect[3]] # Add the highlight annotation = Highlight( rect=rect, quad_points=ArrayObject([FloatObject(quad_point) for quad_point in quad_points]), ) writer.add_annotation(page_number=0, annotation=annotation) # Write the annotated file to disk with open("annotated-pdf.pdf", "wb") as fp: writer.write(fp) ``` 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Cropping works by adjusting the viewbox. That means content that was cropped away can still be restored. ``` ```python from pypdf import PdfReader, PdfWriter reader = PdfReader("example.pdf") writer = PdfWriter() # Add page 1 from reader to output document, unchanged. writer.add_page(reader.pages[0]) # Add page 2 from reader, but rotated clockwise 90 degrees. writer.add_page(reader.pages[1].rotate(90)) # Add page 3 from reader, but crop it to half size. page3 = reader.pages[2] page3.mediabox.upper_right = ( page3.mediabox.right / 2, page3.mediabox.top / 2, ) writer.add_page(page3) # Write to pypdf-output.pdf. with open("pypdf-output.pdf", "wb") as fp: writer.write(fp) ``` ## Page rotation The most typical rotation is a clockwise rotation of the page by multiples of 90 degrees. That is done when the orientation of the page is wrong. You can do that with the {func}`~pypdf._page.PageObject.rotate` method: ```python from pypdf import PdfReader, PdfWriter reader = PdfReader("input.pdf") writer = PdfWriter() writer.add_page(reader.pages[0]) writer.pages[0].rotate(90) with open("output.pdf", "wb") as fp: writer.write(fp) ``` The rotate method is typically preferred over the `page.add_transformation(Transformation().rotate())` method, because `rotate` will ensure that the page is still in the mediabox/cropbox. The transformation object operates on the coordinates of the page contents and does not change the mediabox or cropbox. ## Plain Merge ![](plain-merge.png) is the result of ```python from pypdf import PdfReader, PdfWriter, Transformation # Get the data reader_base = PdfReader("labeled-edges-center-image.pdf") page_base = reader_base.pages[0] reader = PdfReader("box.pdf") page_box = reader.pages[0] page_base.merge_page(page_box) # Write the result back writer = PdfWriter() writer.add_page(page_base) with open("merged-foo.pdf", "wb") as fp: writer.write(fp) ``` ## Merge with Rotation ![](merge-45-deg-rot.png) ```python from pypdf import PdfReader, PdfWriter, Transformation # Get the data reader_base = PdfReader("labeled-edges-center-image.pdf") page_base = reader_base.pages[0] reader = PdfReader("box.pdf") page_box = reader.pages[0] # Apply the transformation transformation = Transformation().rotate(45) page_box.add_transformation(transformation) page_base.merge_page(page_box) # Write the result back writer = PdfWriter() writer.add_page(page_base) with open("merged-foo.pdf", "wb") as fp: writer.write(fp) ``` If you add the `expand` parameter: ```python transformation = Transformation().rotate(45) page_box.add_transformation(transformation) page_base.merge_page(page_box, expand=True) ``` you get: ![](merge-rotate-expand.png) Alternatively, you can move the merged image a bit to the right by using ```python op = Transformation().rotate(45).translate(tx=50) ``` ![](merge-translated.png) ## Scaling In pypdf, the content and the page can either be scaled together or separately. Content scaling scales the contents on a page, and page scaling scales just the page size (the canvas). Typically, you want to combine both. ![](scaling.png) ### Scaling both the Page and contents together ```python from pypdf import PdfReader, PdfWriter # Read the input reader = PdfReader("resources/side-by-side-subfig.pdf") page = reader.pages[0] # Scale page.scale_by(0.5) # Write the result to a file writer = PdfWriter() writer.add_page(page) writer.write("out.pdf") ``` ### Scaling the content only The content is scaled around the origin of the coordinate system. Typically, that is the lower-left corner. ```python from pypdf import PdfReader, PdfWriter, Transformation # Read the input reader = PdfReader("resources/side-by-side-subfig.pdf") page = reader.pages[0] # Scale op = Transformation().scale(sx=0.7, sy=0.7) page.add_transformation(op) # Write the result to a file writer = PdfWriter() writer.add_page(page) writer.write("out-pg-transform.pdf") ``` ### Scaling the page only To scale the page by `sx` in the X direction and `sy` in the Y direction: ```python from pypdf.generic import RectangleObject mb = page.mediabox page.mediabox = self.mediabox.scale(sx, sy) ``` If you wish to have more control, you can adjust the various page boxes directly: ```python from pypdf.generic import RectangleObject mb = page.mediabox page.mediabox = RectangleObject((mb.left, mb.bottom, mb.right, mb.top)) page.cropbox = RectangleObject((mb.left, mb.bottom, mb.right, mb.top)) page.trimbox = RectangleObject((mb.left, mb.bottom, mb.right, mb.top)) page.bleedbox = RectangleObject((mb.left, mb.bottom, mb.right, mb.top)) page.artbox = RectangleObject((mb.left, mb.bottom, mb.right, mb.top)) ``` ### pypdf._page.MERGE_CROP_BOX `pypdf<=3.4.0` used to merge the other page with `trimbox`. `pypdf>3.4.0` changes this behavior to `cropbox`. In case anybody has good reasons to use/expect `trimbox`, you can add the following code to get the old behavior: ```python pypdf._page.MERGE_CROP_BOX = "trimbox" ``` # Transforming several copies of the same page We have designed the following business card (A8 format) to advertise our new startup. ![](nup-source.png) We would like to copy this card sixteen times on an A4 page, to print it, cut it, and give it to all our friends. Having learned about the {func}`~pypdf._page.PageObject.merge_page` method and the {class}`~pypdf.Transformation` class, we run the following code. Notice that we had to tweak the media box of the source page to extend it, which is already a dirty hack (in this case). ```python from pypdf import PaperSize, PdfReader, PdfWriter, Transformation # Read source file reader = PdfReader("nup-source.pdf") sourcepage = reader.pages[0] # Create a destination file, and add a blank page to it writer = PdfWriter() destpage = writer.add_blank_page(width=PaperSize.A4.height, height=PaperSize.A4.width) # Extend source page mediabox sourcepage.mediabox = destpage.mediabox # Copy source page to destination page, several times for x in range(4): for y in range(4): # Translate page sourcepage.add_transformation( Transformation().translate( x * PaperSize.A8.height, y * PaperSize.A8.width, ) ) # Merge translated page destpage.merge_page(sourcepage) # Write file with open("nup-dest1.pdf", "wb") as fp: writer.write(fp) ``` And the result is… unexpected. ![](nup-dest1.png) The problem is that, having run ``add_transformation()`` several times on the *same* source page, those transformations add up: for instance, the sixteen transformations are applied to the last copy of the source page, so most of the business cards are *outside* the destination page. We need a way to merge a transformed page, *without* modifying the source page. Here comes {func}`~pypdf._page.PageObject.merge_transformed_page`. With this method: - we no longer need the media box hack of our first try; - transformations are only applied *once*. ```python from pypdf import PaperSize, PdfReader, PdfWriter, Transformation # Read source file reader = PdfReader("nup-source.pdf") sourcepage = reader.pages[0] # Create a destination file, and add a blank page to it writer = PdfWriter() destpage = writer.add_blank_page(width=PaperSize.A4.height, height=PaperSize.A4.width) # Copy source page to destination page, several times for x in range(4): for y in range(4): destpage.merge_transformed_page( sourcepage, Transformation().translate( x * sourcepage.mediabox.width, y * sourcepage.mediabox.height, ), ) # Write file with open("nup-dest2.pdf", "wb") as fp: writer.write(fp) ``` We get the expected result. ![](nup-dest2.png) There is still some work to do, for instance, to insert margins between and around cards, but this is left as an exercise for the reader… pypdf-6.1.2/docs/user/encryption-decryption.md000066400000000000000000000032511507516550200214510ustar00rootroot00000000000000# Encryption and Decryption of PDFs PDF encryption makes use of [`RC4`](https://en.wikipedia.org/wiki/RC4) and [`AES`](https://en.wikipedia.org/wiki/Advanced_Encryption_Standard) algorithms with different key length. `pypdf` supports all of them until `PDF-2.0`, which is the latest PDF standard. `pypdf` use an extra dependency to do encryption or decryption for `AES` algorithms. We recommend [`pyca/cryptography`](https://cryptography.io/en/latest/). Alternatively, you can use [`pycryptodome`](https://pypi.org/project/pycryptodome/). ```{note} Please see the note in the [installation guide](installation.md) for installing the extra dependencies if interacting with PDFs that use AES. ``` ## Encrypt You can encrypt a PDF by using a password: ```python from pypdf import PdfReader, PdfWriter reader = PdfReader("example.pdf") writer = PdfWriter(clone_from=reader) # Add a password to the new PDF writer.encrypt("my-secret-password", algorithm="AES-256") # Save the new PDF to a file with open("encrypted-pdf.pdf", "wb") as f: writer.write(f) ``` The algorithm can be one of `RC4-40`, `RC4-128`, `AES-128`, `AES-256-R5`, `AES-256`. We recommend using `AES-256-R5`. ```{warning} pypdf uses `RC4` by default for compatibility if you omit the "algorithm" parameter. Since `RC4` is insecure, you should use `AES` algorithms. ``` ## Decrypt You can decrypt a PDF using the appropriate password: ```python from pypdf import PdfReader, PdfWriter reader = PdfReader("encrypted-pdf.pdf") if reader.is_encrypted: reader.decrypt("my-secret-password") writer = PdfWriter(clone_from=reader) # Save the new PDF to a file with open("decrypted-pdf.pdf", "wb") as f: writer.write(f) ``` pypdf-6.1.2/docs/user/error-hierarchy.png000066400000000000000000001423111507516550200203730ustar00rootroot00000000000000‰PNG  IHDRűPź8<4»zTXtRaw profile type exifxÚ­›éuÜş–…˙#ŠóƵ^~,É’%űÚď¶e©ä"‹Ď°6ű˙sĚ˙đ§ÄäMLĄć–łĺOl±ůÎ/Ő>ÚýélĽ?ďź3¬˝űé}“ěë€ç­Ŕkx”ţĽşÎűéÇŢîáĆç÷M}ńőuˇ××ĺmĐťőűú8HŢ÷Ďű.ľ.ÔöóKnµ|ęx]hľNĽCy}Ç÷a=/ú·ůôF!J+qŁŕý.Řűł>#úöˇóZůézýîC1ĽÄŕ_# 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Pˇ&ÍBń¸ÉĹŹ?~„ sçÎŤČ_ ‡ŞT©R·nÝ/^ś˙z8.˛ú ­d:ËicĹĎ4ďŻ;z®˛i%»NP 5›”źŠť[ÁĐü÷s*XŇűEÜyŽíăË˙cE3¶NÎĂNq\ä‡%üiи#ˇűd}ťşQÜBân¶řP&Žč]śŁHyš¶ŕ´űw˙‚O(q;Ůu8(_›µ˛ľypűrŠ¶uźÂDz­thťÍôŻż¨ÜőŮ[íę1V®ăDĹ*ФA7łźtíÚuéŇĄ111ĺË—×ďäJÝD·ă°ęQŚö‘9ĽÇż2}+߸j´§Ć_ŢüęíIźşęKďGňYáśyѨŤrz×O3 ęKíŰwÇGé† hxď7|S5ČşI´í˙]Ü°+%xÉ»0”.k]ŇŔŚo5‚xşŰRň6…Ü@ç!nKBÚ“vő Ďj4KÝéˇY¬[­%-m‘çÔĘ1_:·ľ5Ę]ź˝ŐĽJÓuJ©»kŕ×ÜAňůJôGoř¸/w?_ŽaU<~^Y˝ǧKéÝKۆRJĺ÷ Ó%őľt‡ý~:̝㻥$>H‹P>Éţ )Łíň>ÍxNťĹ˨ćěE÷VT-Ka.ź"zźżŚ`BE “RJÝĎeáđ®‚×ý±~}Ťw±!ýYřjÖw ©űˇ3ľ0ťsOňŮŢÉ×—ř†0úm^nŻ'x”RęîĎx~›ÍâŤŘZ2Ś“Śý7mҾܽżšĽŔ ˛+‰Ú]üPnVBÝ“ĽŞńţŻĽ¸‘Ą+Ů{Ś«‚_qB›ŇĄ E4ŮQJ©{#ă©IÝČűqK2r˛6D•®t#†7Ň0(ĄÔÍĄ3—•RJ)ĄŹRJ)Ą”f 720) and footer (y < 50). ```python from pypdf import PdfReader reader = PdfReader("GeoBase_NHNC1_Data_Model_UML_EN.pdf") page = reader.pages[3] parts = [] def visitor_body(text, cm, tm, font_dict, font_size): y = cm[5] if 50 < y < 720: parts.append(text) page.extract_text(visitor_text=visitor_body) text_body = "".join(parts) print(text_body) ``` ### Example 2: Extract rectangles and texts into an SVG file The following example converts page three of [this PDF document](https://github.com/py-pdf/pypdf/blob/main/resources/GeoBase_NHNC1_Data_Model_UML_EN.pdf) into an [SVG file](https://en.wikipedia.org/wiki/Scalable_Vector_Graphics). Such an SVG export may help to understand what is going on in a page. ```python from pypdf import PdfReader import svgwrite reader = PdfReader("GeoBase_NHNC1_Data_Model_UML_EN.pdf") page = reader.pages[2] dwg = svgwrite.Drawing("GeoBase_test.svg", profile="tiny") def visitor_svg_rect(op, args, cm, tm): if op == b"re": (x, y, w, h) = (args[i].as_numeric() for i in range(4)) dwg.add(dwg.rect((x, y), (w, h), stroke="red", fill_opacity=0.05)) def visitor_svg_text(text, cm, tm, font_dict, font_size): (x, y) = (cm[4], cm[5]) dwg.add(dwg.text(text, insert=(x, y), fill="blue")) page.extract_text( visitor_operand_before=visitor_svg_rect, visitor_text=visitor_svg_text ) dwg.save() ``` The SVG generated here is bottom-up because the coordinate systems of PDF and SVG differ. Unfortunately, in complicated PDF documents the coordinates given to the visitor functions may be wrong. ## Why Text Extraction is hard ### Unclear Objective Extracting text from a PDF can be tricky. In several cases, there is no clear answer to what the expected result should look like: 1. **Paragraphs**: Should the text of a paragraph have line breaks at the same places where the original PDF had them or should it rather be one block of text? 2. **Page numbers**: Should they be included in the extract? 3. **Headers and Footers**: Similar to page numbers - should they be extracted? 4. **Outlines**: Should outlines be extracted at all? 5. **Formatting**: If the text is **bold** or *italic*, should it be included in the output? 6. **Tables**: Should the text extraction skip tables? Should it extract just the text? Should the borders be shown in some Markdown-like way or should the structure be present e.g. as an HTML table? How would you deal with merged cells? 7. **Captions**: Should image and table captions be included? 8. **Ligatures**: The Unicode symbol [U+FB00](https://www.compart.com/de/unicode/U+FB00) is a single symbol ff for two lowercase letters 'f'. Should that be parsed as the Unicode symbol 'ff' or as two ASCII symbols 'ff'? 9. **SVG images**: Should the text parts be extracted? 10. **Mathematical Formulas**: Should they be extracted? Formulas have indices and nested fractions. 11. **Whitespace characters**: How many new lines should be extracted for 3 cm of vertical whitespace? How many spaces should be extracted if there is 3 cm of horizontal whitespace? When would you extract tabs and when spaces? 12. **Footnotes**: When the text of multiple pages is extracted, where should footnotes be shown? 13. **Hyperlinks and Metadata**: Should it be extracted at all? Where should it be placed in which format? 14. **Linearization**: Assume you have a floating figure in between a paragraph. Do you first finish the paragraph, or do you put the figure text in between? Then there are issues where most people would agree on the correct output, but the way PDF stores information just makes it hard to achieve that: 1. **Tables**: Typically, tables are just absolutely positioned text. In the worst case, every single letter could be absolutely positioned. That makes it hard to tell where columns / rows are. 2. **Images**: Sometimes PDFs do not contain the text as it is displayed, but instead an image. You notice that when you cannot copy the text. Then there are PDF files that contain an image and a text layer in the background. That typically happens when a document was scanned. Although the scanning software (OCR) is pretty good today, it still fails once in a while. pypdf is no OCR software; it will not be able to detect those failures. pypdf will also never be able to extract text from images. Finally, there are issues that pypdf will deal with. If you find such a text extraction bug, please share the PDF with us so we can work on it! ### Missing Semantic Layer The PDF file format is all about producing the desired visual result for printing. It was not created for parsing the content. PDF files don't contain a semantic layer. Specifically, there is no information what the header, footer, page numbers, tables, and paragraphs are. The visual appearance is there, and people might find heuristics to make educated guesses, but there is no way of being certain. This is a shortcoming of the PDF file format, not of pypdf. It is possible to apply machine learning on PDF documents to make good heuristics, but that will not be part of pypdf. However, pypdf could be used to feed such a machine learning system with the relevant information. ### Whitespaces The PDF format is meant for printing. It is not designed to be read by machines. The text within a PDF document is absolutely positioned, meaning that every single character could be positioned on the page. The text > This is a test document by Ethan Nelson. can be represented as > [(This is a )9(te)-3(st)9( do)-4(cu)13(m)-4(en)12(t )-3(b)3(y)-3( )9(Et)-2(h)3(an)4( Nels)13(o)-5(n)3(.)] TJ Where the numbers are adjustments of vertical space. This representation used within the PDF file makes it very hard to guarantee correct whitespaces. More information: * [issue #1507](https://github.com/py-pdf/pypdf/issues/1507) * [Negative numbers in PDF content stream text object](https://stackoverflow.com/a/28203655/562769) * Mark Stephens: [Understanding PDF text objects](https://blog.idrsolutions.com/understanding-pdf-text-objects/), 2010. ## OCR vs. Text Extraction Optical Character Recognition (OCR) is the process of extracting text from images. Software which does this is called *OCR software*. The [tesseract OCR engine](https://github.com/tesseract-ocr/tesseract) is the most commonly known open source OCR software. pypdf is **not** OCR software. ### Digitally-born vs. Scanned PDF files PDF documents can contain images and text. PDF files don't store text in a semantically meaningful way, but in a way that makes it easy to show the text on screen or print it. For this reason, text extraction from PDFs is hard. If you scan a document, the resulting PDF typically shows the image of the scan. Scanners then also run OCR software and put the recognized text in the background of the image. pypdf can extract this result of the scanners OCR software. However, in such cases, it's recommended to directly use OCR software as errors can accumulate: The OCR software is not perfect in recognizing the text. Then it stores the text in a format that is not meant for text extraction and pypdf might make mistakes parsing that. Hence, I would distinguish three types of PDF documents: * **Digitally born PDF files**: The file was created digitally on the computer. It can contain images, texts, links, outline items (a.k.a., bookmarks), JavaScript, ... If you Zoom in a lot, the text still looks sharp. * **Scanned PDF files**: Any number of pages was scanned. The images were then stored in a PDF file. Hence, the file is just a container for those images. You cannot copy the text, you don't have links, outline items, JavaScript. * **OCRed PDF files**: The scanner ran OCR software and put the recognized text in the background of the image. Hence, you can copy the text, but it still looks like a scan. If you zoom in enough, you can recognize pixels. ### Can we just always use OCR? You might now wonder if it makes sense to just always use OCR software. If the PDF file is digitally-born, you can render it to an image. I would recommend not to do that. Text extraction software like pypdf can use more information from the PDF than just the image. It can know about fonts, encodings, typical character distances and similar topics. That means pypdf has a clear advantage when it comes to characters which are easy to confuse such as `oO0ö`. **pypdf will never confuse characters**. It just reads what is in the file. pypdf also has an edge when it comes to characters which are rare, e.g. 🤰. OCR software will not be able to recognize smileys correctly. ## Attempts to prevent text extraction If people who share PDF documents want to prevent text extraction, they have multiple ways to do so: 1. Store the contents of the PDF as an image 2. [Use a scrambled font](https://stackoverflow.com/a/43466923/562769) However, text extraction cannot be completely prevented if people should still be able to read the document. In the worst case, people can make a screenshot, print it, scan it, and run OCR over it. pypdf-6.1.2/docs/user/file-size.md000066400000000000000000000102401507516550200167640ustar00rootroot00000000000000# Reduce PDF File Size There are multiple ways to reduce the size of a given PDF file. The easiest one is to remove content (e.g., images) or pages. ## Removing duplication Some PDF documents contain the same object multiple times. For example, if an image appears three times in a PDF, it could be embedded three times. Or it can be embedded once and referenced twice. When adding data to a PdfWriter, the data is copied while respecting the original format. For example, if two pages include the same image which is duplicated in the source document, the object will be duplicated in the PdfWriter object. Additionally, when you delete objects in a document, pypdf cannot easily identify whether the objects are used elsewhere or not or if the user wants to keep them in. When writing the PDF file, these objects will be hidden within (part of the file, but not displayed). To reduce the file size, use a compression call: `writer.compress_identical_objects(remove_identicals=True, remove_orphans=True)` * `remove_identicals` enables/disables compression merging identical objects. * `remove_orphans` enables/disables suppression of unused objects. It is recommended to apply this process just before writing to the file/stream. It depends on the PDF how well this works, but we have seen an 86% file reduction (from 5.7 MB to 0.8 MB) within a real PDF. ## Removing Images ```python from pypdf import PdfWriter writer = PdfWriter(clone_from="example.pdf") writer.remove_images() with open("out.pdf", "wb") as f: writer.write(f) ``` ## Reducing Image Quality If we reduce the quality of the images within the PDF, we can **sometimes** reduce the file size of the PDF overall. That depends on how well the reduced quality image can be compressed. ```python from pypdf import PdfWriter writer = PdfWriter(clone_from="example.pdf") for page in writer.pages: for img in page.images: img.replace(img.image, quality=80) with open("out.pdf", "wb") as f: writer.write(f) ``` ## Lossless Compression pypdf supports the FlateDecode filter which uses the zlib/deflate compression method. It is a lossless compression, meaning the resulting PDF looks exactly the same. Deflate compression can be applied to a page via {meth}`page.compress_content_streams `: ```python from pypdf import PdfWriter writer = PdfWriter(clone_from="example.pdf") for page in writer.pages: page.compress_content_streams() # This is CPU intensive! with open("out.pdf", "wb") as f: writer.write(f) ``` `page.compress_content_streams` uses [`zlib.compress`](https://docs.python.org/3/library/zlib.html#zlib.compress) and supports the `level` parameter: `level=0` means no compression, `level=9` refers to the highest compression. Using this method, we have seen a reduction by 70% (from 11.8 MB to 3.5 MB) with a real PDF. ## Removing Sources When a page is removed from the page list, its content will still be present in the PDF file. This means that the data may still be used elsewhere. Simply removing a page from the page list will reduce the page count but not the file size. To exclude the content completely, the pages should not be added to the PDF using the PdfWriter.append() function. Instead, only the desired pages should be selected for inclusion (note: [PR #1843](https://github.com/py-pdf/pypdf/pull/1843) will add a page deletion feature). There can be issues with poor PDF formatting, such as when all pages are linked to the same resource. In such cases, dropping references to specific pages becomes useless because there is only one source for all pages. Cropping is an ineffective method for reducing the file size because it only adjusts the viewboxes and not the external parts of the source image. Therefore, the content that is no longer visible will still be present in the PDF. ## Going Further The presentation [Putting a Squeeze on Your PDF](https://youtube.com/watch?v=tgOABUhVwFs) has other suggestions. One takeaway is that most of the significant size optimizations usually come from image and font modification. However, font optimization, such as replacing, merging, and subsetting, is not within the functionality of pypdf at the moment. pypdf-6.1.2/docs/user/forms.md000066400000000000000000000130771507516550200162360ustar00rootroot00000000000000# Interactions with PDF Forms ## Reading form fields ```python from pypdf import PdfReader reader = PdfReader("form.pdf") fields = reader.get_form_text_fields() fields == {"key": "value", "key2": "value2"} # You can also get all fields: fields = reader.get_fields() ``` ## Filling out forms ```python from pypdf import PdfReader, PdfWriter reader = PdfReader("form.pdf") writer = PdfWriter() page = reader.pages[0] fields = reader.get_fields() writer.append(reader) writer.update_page_form_field_values( writer.pages[0], {"fieldname": "some filled in text"}, auto_regenerate=False, ) with open("filled-out.pdf", "wb") as output_stream: writer.write(output_stream) ``` Generally speaking, you will always want to use `auto_regenerate=False`. The parameter is `True` by default for legacy compatibility, but this flags the PDF processor to recompute the field's rendering, and may trigger a "save changes" dialog for users who open the generated PDF. ## Some notes about form fields and annotations PDF forms have a dual-nature approach to the fields: * Within the root object, an `/AcroForm` structure exists. Inside it, you could find (optional): - some global elements (Fonts, Resources,...) - some global flags (like `/NeedAppearances` (set/cleared with `auto_regenerate` parameter in `update_page_form_field_values()`) that indicates if the reading program should re-render the visual fields upon document launch) - `/XFA` that houses a form in XDP format (very specific XML that describes the form rendered by some viewers); the `/XFA` form overrides the page content - `/Fields` that houses an array of indirect references that reference the upper _Field_ Objects (roots) * Within the page `/Annots`, you will spot `/Widget` annotations that define the visual rendering. To flesh out this overview: * The core-specific properties of a field are: - `/FT`: The field type (Button, Text, Choice, or Signature). - `/T`: The partial field name. - `/V`: The field’s value, whose format varies depending on the field type. - `/DV`: The default value to which the field reverts when a reset-form action is executed. * To streamline readability, _Field_ Objects and _Widget_ Objects can be fused housing all properties. * Fields can be organized hierarchically, id est one field can be placed under another. In such instances, the `/Parent` will have an IndirectObject providing Bottom-Up links and `/Kids` is an array carrying IndirectObjects for Top-Down navigation; _Widget_ Objects are still required for visual rendering. To call upon them, use the *fully qualified field name* (where all the individual names of the parent objects are separated by `.`) For instance, take two (visual) fields both called _city_, but attached below _sender_ and _receiver_; the corresponding full names will be _sender.city_ and _receiver.city_. * When a field is repeated on multiple pages, the Field Object will have many _Widget_ Objects in `/Kids`. These objects are pure _widgets_, containing no _field_ specific data. * If Fields stores only hidden values, no _Widgets_ are required. In _pypdf_ fields are extracted from the `/Fields` array: ```python from pypdf import PdfReader reader = PdfReader("form.pdf") fields = reader.get_fields() ``` ```python from pypdf import PdfReader from pypdf.constants import AnnotationDictionaryAttributes reader = PdfReader("form.pdf") fields = [] for page in reader.pages: for annot in page.annotations: annot = annot.get_object() if annot[AnnotationDictionaryAttributes.Subtype] == "/Widget": fields.append(annot) ``` However, while similar, there are some relevant differences between the two above blocks of code. Most importantly, the first block will return a list of Field objects, whereas the second will return more generic dictionary-like objects. The objects lists will *mostly* reference the same object in the underlying PDF, meaning you'll find that `obj_taken_fom_first_list.indirect_reference == obj_taken_from _second_list.indirect_reference`. Field objects are generally more ergonomic, as the exposed data can be accessed via clearly named properties. However, the more generic dictionary-like objects will contain data that the Field object does not expose, such as the Rect (the widget's position on the page). Therefore, the correct approach depends on your use case. However, it is also important to note that the two lists do not *always* refer to the same underlying PDF object. For example, if the form contains radio buttons, you will find that `reader.get_fields()` will get the parent object (the group of radio buttons) whereas `page.annotations` will return all the child objects (the individual radio buttons). ```{note} Remember that fields are not stored in pages; if you use `add_page()` the field structure is not copied. It is recommended to use `.append()` with the proper parameters instead. ``` In case of missing _field_ objects in `/Fields`, `writer.reattach_fields()` will parse page(s) annotations and will reattach them. This fix cannot guess intermediate fields and will not report fields using the same _name_. ## Identify pages where fields are used To ease locating page fields you can use `get_pages_showing_field` of PdfReader or PdfWriter. This method accepts a field object, a *PdfObject* that represents a field (as extracted from `_root_object["/AcroForm"]["/Fields"]`). The method returns a list of pages, because a field can have multiple widgets as mentioned previously (e.g., radio buttons or text displayed on multiple pages). 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€\´ €\´ €\´ €\´ €\´ €\´ €\?řÜbÖ=.~IEND®B`‚pypdf-6.1.2/docs/user/handle-attachments.md000066400000000000000000000074461507516550200206570ustar00rootroot00000000000000# Handle Attachments PDF documents can contain attachments, from time to time named embedded file as well. ## Retrieve Attachments Attachments have a name, but it might not be unique. For this reason, the value of `reader.attachments["attachment_name"]` is a list. You can extract all attachments like this: ```python from pypdf import PdfReader reader = PdfReader("example.pdf") for name, content_list in reader.attachments.items(): for i, content in enumerate(content_list): with open(f"{name}-{i}", "wb") as fp: fp.write(content) ``` Alternatively, you can retrieve them in an object-oriented fashion if you need further details for these files: ```python from pypdf import PdfReader reader = PdfReader("example.pdf") for attachment in reader.attachment_list: print(attachment.name, attachment.alternative_name, attachment.content) ``` ## Add Attachments To add a new attachment, use the following code: ```python from pypdf import PdfWriter writer = PdfWriter(clone_from="example.pdf") writer.add_attachment(filename="test.txt", data=b"Hello World!") ``` As you can see, the basic attachment properties are its name and content. If you want to modify further properties of it, the returned object provides corresponding setters: ```python import datetime import hashlib from pypdf import PdfWriter from pypdf.generic import create_string_object, ByteStringObject, NameObject, NumberObject writer = PdfWriter(clone_from="example.pdf") embedded_file = writer.add_attachment(filename="test.txt", data=b"Hello World!") embedded_file.size = NumberObject(len(b"Hello World!")) embedded_file.alternative_name = create_string_object("test1.txt") embedded_file.description = create_string_object("My test file") embedded_file.subtype = NameObject("/text/plain") embedded_file.checksum = ByteStringObject(hashlib.md5(b"Hello World!").digest()) embedded_file.modification_date = datetime.datetime.now(tz=datetime.timezone.utc) # embedded_file.content = "My new content." embedded_file.write("output.pdf") ``` The same functionality is available if you iterate over the attachments of a writer using `writer.attachment_list`. ## Delete Attachments To delete an existing attachment, use the following code: ```python from pypdf import PdfWriter writer = PdfWriter(clone_from="example.pdf") attachment = writer.add_attachment(filename="test.txt", data=b"Hello World!") attachment.delete() assert list(writer.attachment_list) == [] ``` Please note that this will not delete the associated file relationship if it exists. Deleting them as well would require us to know where this has been defined, which requires more complexity. For now, please consider looking for the corresponding definition yourself and delete it from the array. ### PDF/A compliance The following example shows how to add an attachment to a PDF/A-3B compliant document without breaking compliance: ```python from pypdf import PdfWriter from pypdf.constants import AFRelationship from pypdf.generic import create_string_object, ArrayObject, NameObject writer = PdfWriter(clone_from="pdf_a3b.pdf") attachment = writer.add_attachment(filename="test.txt", data="Hello World!") attachment.subtype = NameObject("/text/plain") attachment.associated_file_relationship = NameObject(AFRelationship.SUPPLEMENT) attachment.alternative_name = create_string_object(attachment.name) if "/AF" in writer.root_object: af = writer.root_object["/AF"].get_object() else: af = ArrayObject() writer.root_object["/AF"] = af af.append(attachment.pdf_object.indirect_reference) writer.write("pdf_a3b_output.pdf") ``` This example marks a relationship of the attachment to the whole document. Alternatively, it can be added to most of the other PDF objects as well. For details, see the corresponding PDF specification, like section 14.13 of the PDF 2.0 specification. pypdf-6.1.2/docs/user/installation.md000066400000000000000000000046561507516550200176140ustar00rootroot00000000000000# Installation There are several ways to install pypdf. The most common option is to use pip. ## pip pypdf requires Python 3.9+ to run. Typically, Python comes with `pip`, a package installer. Using it, you can install pypdf: ```bash pip install pypdf ``` If you are not a superuser (a system administrator / root), you can also just install pypdf for your current user: ```bash pip install --user pypdf ``` ### Optional dependencies pypdf tries to be as self-contained as possible, but for some tasks, the amount of work to properly maintain the code would be too high. This is especially the case for cryptography and image formats. If you simply want to install all optional dependencies, run: ``` pip install pypdf[full] ``` Alternatively, you can install just some: If you plan to use pypdf for encrypting or decrypting PDFs that use AES, you will need to install some extra dependencies. Encryption using RC4 is supported using the regular installation. ``` pip install pypdf[crypto] ``` If you plan to use image extraction, you need Pillow: ``` pip install pypdf[image] ``` For JBIG2 support, you need to install a global OS-level package as well: [`jbig2dec`](https://github.com/ArtifexSoftware/jbig2dec) The installation procedure depends on our operating system. For Ubuntu, use the following, for example: ``` sudo apt-get install jbig2dec ``` ## Python Version Support Since pypdf 4.0, every release, including point releases, should work with all supported versions of [Python](https://devguide.python.org/versions/). Thus, every point release is designed to work with all existing Python versions, excluding end-of-life versions. Previous versions of pypdf support the following versions of Python: | Python | 3.11 | 3.10 | 3.9 | 3.8 | 3.7 | 3.6 | 2.7 | |------------------------|:----:|:----:|:---:|:---:|:---:|:---:|:---:| | pypdf 3.x | âś… | âś… | âś… | âś… | âś… | âś… | ❌ | | PyPDF2 >= 2.0 | âś… | âś… | âś… | âś… | âś… | âś… | ❌ | | PyPDF2 1.20.0 - 1.28.4 | ❌ | âś… | âś… | âś… | âś… | âś… | âś… | | PyPDF2 1.15.0 - 1.20.0 | ❌ | ❌ | ❌ | ❌ | ❌ | ❌ | âś… | ## Anaconda Anaconda users can [install pypdf via conda-forge](https://anaconda.org/conda-forge/pypdf). ## Development Version In case you want to use the current version under development: ```bash pip install git+https://github.com/py-pdf/pypdf.git ``` pypdf-6.1.2/docs/user/merge-45-deg-rot.png000066400000000000000000006260611507516550200201630ustar00rootroot00000000000000‰PNG  IHDRşĎ¤˙sBITŰáOŕtEXtSoftwaremate-screenshotČ–đJ IDATxśěÝ{”]ea˙˙綯ç~Î\23É„I@P@j€  (Š*VĐŻ­ÖŐËŞ­íެö·~K^*^j­VůR°„ZQT.I±$!!†\H™űś93綯ĎóüţŘ2Ť d“d’ÉĺóZ¬YĂ™3űě39łĎ{ö~öłi«Ů ŻŹÍö 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Basic Example ```python from pypdf import PdfWriter merger = PdfWriter() for pdf in ["file1.pdf", "file2.pdf", "file3.pdf"]: merger.append(pdf) merger.write("merged-pdf.pdf") merger.close() ``` For more details, see an excellent answer on [StackOverflow](https://stackoverflow.com/questions/3444645/merge-pdf-files) by Paul Rooney. ```{note} Dealing with large PDF files might reach the recursion limit of the current Python interpreter. In these cases, increasing the limit might help: ```python import sys # Example: Increase the current limit by factor 5. sys.setrecursionlimit(sys.getrecursionlimit() * 5) ``` ``` ## Showing more merging options ```python from pypdf import PdfWriter merger = PdfWriter() input1 = open("document1.pdf", "rb") input2 = open("document2.pdf", "rb") input3 = open("document3.pdf", "rb") # Add the first 3 pages of input1 document to output merger.append(fileobj=input1, pages=(0, 3)) # Insert the first page of input2 into the output beginning after the second page merger.merge(position=2, fileobj=input2, pages=(0, 1)) # Append entire input3 document to the end of the output document merger.append(input3) # Write to an output PDF document output = open("document-output.pdf", "wb") merger.write(output) # Close file descriptors merger.close() output.close() ``` ## append `append` has been slightly extended in `PdfWriter`. See {func}`~pypdf.PdfWriter.append` for more details. ### Examples ```python # Append the first 10 pages of source.pdf writer.append("source.pdf", (0, 10)) # Append the first and 10th page from reader and create an outline writer.append(reader, "page 1 and 10", [0, 9]) ``` During merging, the relevant named destination will also be imported. If you want to insert pages in the middle of the destination, use `merge` (which provides an insertion position). You can insert the same page multiple times, if necessary, even using a list-based syntax: ```python # Insert pages 2 and 3, with page 1 before, between, and after writer.append(reader, [0, 1, 0, 2, 0]) ``` ## add_page / insert_page It is recommended to use `append` or `merge` instead. ## Merging forms When merging forms, some form fields may have the same names, preventing access to some data. A grouping field should be added before adding the source PDF to prevent that. The original fields will be identified by adding the group name. For example, after calling `reader.add_form_topname("form1")`, the field previously named `field1` is now identified as `form1.field1` when calling `reader.get_form_text_fields(True)` or `reader.get_fields()`. After that, you can append the input PDF completely or partially using `writer.append` or `writer.merge`. If you insert a set of pages, only those fields will be listed. ## reset_translation During cloning, if an object has been already cloned, it will not be cloned again, and a pointer to this previously cloned object is returned instead. Because of that, if you add/merge a page that has already been added, the same object will be added the second time. If you modify any of these two pages later, both pages can be modified independently. To reset, call `writer.reset_translation(reader)`. ## Advanced cloning To prevent side effects between pages/objects and all objects linked cloning is done during the merge. This process will be automatically applied if you use `PdfWriter.append/merge/add_page/insert_page`. If you want to clone an object before attaching it "manually," use the `clone` method of any *PdfObject*: ```python cloned_object = object.clone(writer) ``` If you try to clone an object already belonging to the writer, it will return the same object: ```python assert cloned_object == object.clone(writer) ``` The same holds true if you try to clone an object twice. It will return the previously cloned object: ```python assert object.clone(writer) == object.clone(writer) ``` Please note that if you clone an object, you will clone all the objects below as well, including the objects pointed by *IndirectObject*. Due to this, if you clone a page that includes some articles (`"/B"`), not only the first article, but also all the chained articles and the pages where those articles can be read will be copied. This means that you may copy lots of objects which will be saved in the output PDF as well. To prevent this, you can provide the list of fields in the dictionaries to be ignored: ```python new_page = writer.add_page(reader.pages[0], excluded_fields=["/B"]) ``` ### Merging rotated pages If you are working with rotated pages, you might want to call {func}`~pypdf._page.PageObject.transfer_rotation_to_content` on the page before merging to avoid wrongly rotated results: ```python for page in writer.pages: if page.rotation != 0: page.transfer_rotation_to_content() page.merge_page(background, over=False) ``` pypdf-6.1.2/docs/user/metadata.md000066400000000000000000000161631507516550200166670ustar00rootroot00000000000000# Metadata PDF files can have two types of metadata: "Regular" and XMP ones. They can both exist at the same time. ## Reading metadata ```python from pypdf import PdfReader reader = PdfReader("example.pdf") meta = reader.metadata # All the following could be None! print(meta.title) print(meta.author) print(meta.subject) print(meta.creator) print(meta.producer) print(meta.creation_date) print(meta.modification_date) ``` ## Writing metadata ```python from datetime import datetime from pypdf import PdfReader, PdfWriter reader = PdfReader("example.pdf") writer = PdfWriter() # Add all pages to the writer for page in reader.pages: writer.add_page(page) # If you want to add the old metadata, include these two lines if reader.metadata is not None: writer.add_metadata(reader.metadata) # Format the current date and time for the metadata utc_time = "-05'00'" # UTC time optional time = datetime.now().strftime(f"D\072%Y%m%d%H%M%S{utc_time}") # Add the new metadata writer.add_metadata( { "/Author": "Martin", "/Producer": "Libre Writer", "/Title": "Title", "/Subject": "Subject", "/Keywords": "Keywords", "/CreationDate": time, "/ModDate": time, "/Creator": "Creator", "/CustomField": "CustomField", } ) # Save the new PDF to a file with open("meta-pdf.pdf", "wb") as f: writer.write(f) ``` ## Updating metadata ```python from pypdf import PdfWriter writer = PdfWriter(clone_from="example.pdf") # Change some values writer.add_metadata( { "/Author": "Martin", "/Producer": "Libre Writer", "/Title": "Title", } ) # Clear all data but keep the entry in PDF writer.metadata = {} # Replace all entries with new set of entries writer.metadata = { "/Author": "Martin", "/Producer": "Libre Writer", } # Save the new PDF to a file with open("meta-pdf.pdf", "wb") as f: writer.write(f) ``` ## Removing metadata entry ```python from pypdf import PdfWriter writer = PdfWriter("example.pdf") # Remove Metadata (/Info entry) writer.metadata = None # Save the new PDF to a file with open("meta-pdf.pdf", "wb") as f: writer.write(f) ``` ## Reading XMP metadata ```python from pypdf import PdfReader reader = PdfReader("example.pdf") meta = reader.xmp_metadata if meta: print(meta.dc_title) print(meta.dc_description) print(meta.xmp_create_date) ``` ## Creating XMP metadata You can create XMP metadata easily using the `XmpInformation.create()` method: ```python from pypdf import PdfWriter from pypdf.xmp import XmpInformation # Create a new XMP metadata object xmp = XmpInformation.create() # Set metadata fields xmp.dc_title = {"x-default": "My Document Title"} xmp.dc_creator = ["Author One", "Author Two"] xmp.dc_description = {"x-default": "Document description"} xmp.dc_subject = ["keyword1", "keyword2", "keyword3"] xmp.pdf_producer = "pypdf" # Create a writer and add the metadata writer = PdfWriter() writer.add_blank_page(612, 792) # Add a page writer.xmp_metadata = xmp writer.write("output.pdf") ``` ## Setting XMP metadata fields The `XmpInformation` class provides property-based access for all supported metadata fields: ### Dublin Core fields ```python from datetime import datetime from pypdf.xmp import XmpInformation xmp = XmpInformation.create() # Single value fields xmp.dc_coverage = "Global coverage" xmp.dc_format = "application/pdf" xmp.dc_identifier = "unique-id-123" xmp.dc_source = "Original Source" # Array fields (bags - unordered) xmp.dc_contributor = ["Contributor One", "Contributor Two"] xmp.dc_language = ["en", "fr", "de"] xmp.dc_publisher = ["Publisher One"] xmp.dc_relation = ["Related Doc 1", "Related Doc 2"] xmp.dc_subject = ["keyword1", "keyword2"] xmp.dc_type = ["Document", "Text"] # Sequence fields (ordered arrays) xmp.dc_creator = ["Primary Author", "Secondary Author"] xmp.dc_date = [datetime.now()] # Language alternative fields xmp.dc_title = {"x-default": "Title", "en": "English Title", "fr": "Titre français"} xmp.dc_description = {"x-default": "Description", "en": "English Description"} xmp.dc_rights = {"x-default": "All rights reserved"} ``` ### XMP fields ```python from datetime import datetime # Date fields accept both datetime objects and strings xmp.xmp_create_date = datetime.now() xmp.xmp_modify_date = "2023-12-25T10:30:45Z" xmp.xmp_metadata_date = datetime.now() # Text field xmp.xmp_creator_tool = "pypdf" ``` ### PDF fields ```python xmp.pdf_keywords = "keyword1, keyword2, keyword3" xmp.pdf_pdfversion = "1.4" xmp.pdf_producer = "pypdf" ``` ### XMP Media Management fields ```python xmp.xmpmm_document_id = "uuid:12345678-1234-1234-1234-123456789abc" xmp.xmpmm_instance_id = "uuid:87654321-4321-4321-4321-cba987654321" ``` ### PDF/A fields ```python xmp.pdfaid_part = "1" xmp.pdfaid_conformance = "B" ``` ### Clearing metadata fields You can clear any field by assigning `None`: ```python xmp.dc_title = None xmp.dc_creator = None xmp.pdf_producer = None ``` ### Incrementally updating XMP metadata fields When modifying existing XMP metadata, it is often necessary to add or update individual entries while preserving existing values. The XMP properties return standard Python data structures that can be manipulated directly: ```python from pypdf.xmp import XmpInformation xmp = XmpInformation.create() # Language alternative fields return dictionaries title = xmp.dc_title or {} title["en"] = "English Title" title["fr"] = "Titre français" xmp.dc_title = title # Bag fields (unordered collections) return lists subjects = xmp.dc_subject or [] subjects.append("new_keyword") xmp.dc_subject = subjects # Sequence fields (ordered collections) return lists creators = xmp.dc_creator or [] creators.append("New Author") xmp.dc_creator = creators ``` This approach provides direct control over the data structures while maintaining the property-based interface. ## Modifying XMP metadata Modifying XMP metadata is a bit more complicated. As an example, we want to add the following PDF/UA identifier section to the XMP metadata: ```xml 1 ``` This could be written like this: ```python from pypdf import PdfWriter writer = PdfWriter(clone_from="example.pdf") metadata = writer.xmp_metadata assert metadata # Ensure that it is not `None`. rdf_root = metadata.rdf_root xmp_meta = rdf_root.parentNode xmp_document = xmp_meta.parentNode # Please note that without a text node, the corresponding elements might # be omitted completely. pdfuaid_description = xmp_document.createElement("rdf:Description") pdfuaid_description.setAttribute("rdf:about", "") pdfuaid_description.setAttribute("xmlns:pdfuaid", "http://www.aiim.org/pdfua/ns/id/") pdfuaid_part = xmp_document.createElement("pdfuaid:part") pdfuaid_part_text = xmp_document.createTextNode("1") pdfuaid_part.appendChild(pdfuaid_part_text) pdfuaid_description.appendChild(pdfuaid_part) rdf_root.appendChild(pdfuaid_description) metadata.stream.set_data(xmp_document.toxml().encode("utf-8")) writer.write("output.pdf") ``` For further details on modifying the structure, please refer to {py:mod}`xml.dom.minidom`. pypdf-6.1.2/docs/user/migration-1-to-2.md000066400000000000000000000201511507516550200200050ustar00rootroot00000000000000# Migration Guide: 1.x to 2.x `PyPDF2<2.0.0` ([docs](https://pypdf2.readthedocs.io/en/1.27.12/meta/history.html)) is very different from `PyPDF2>=2.0.0` ([docs](../meta/history.md)). Luckily, most changes are simple naming adjustments. This guide helps you to make the step from `PyPDF2 1.x` (or even the original PyPdf) to `PyPDF2>=2.0.0`. You can execute your code with the updated version and show deprecation warnings by running `python -W all your_code.py`. # Imports and Modules * `PyPDF2.utils` no longer exists * `PyPDF2.pdf` no longer exists. You can import from `PyPDF2` directly or from `PyPDF2.generic` # Naming Adjustments ## Classes The base classes were renamed as they also allow operating with BytesIO streams instead of files. Also, the `strict` parameter changed the default value from `strict=True` to `strict=False`. * `PdfFileReader` âž” `PdfReader` * `PdfFileWriter` âž” `PdfWriter` * `PdfFileMerger` âž” `PdfMerger` PdfFileReader and PdfFileMerger no longer have the `overwriteWarnings` parameter. The new behavior is `overwriteWarnings=False`. ## Function, Method, and Property Names In `PyPDF2.xmp.XmpInformation`: * `rdfRoot` âž” `rdf_root` * `xmp_createDate` âž” `xmp_create_date` * `xmp_creatorTool` âž” `xmp_creator_tool` * `xmp_metadataDate` âž” `xmp_metadata_date` * `xmp_modifyDate` âž” `xmp_modify_date` * `xmpMetadata` âž” `xmp_metadata` * `xmpmm_documentId` âž” `xmpmm_document_id` * `xmpmm_instanceId` âž” `xmpmm_instance_id` In `PyPDF2.generic`: * `readObject` âž” `read_object` * `convertToInt` âž” `convert_to_int` * `DocumentInformation.getText` âž” `DocumentInformation._get_text` : This method should typically not be used; please let me know if you need it. * `readHexStringFromStream` âž” `read_hex_string_from_stream` * `initializeFromDictionary` âž” `initialize_from_dictionary` * `createStringObject` âž” `create_string_object` * `TreeObject.hasChildren` âž” `TreeObject.has_children` * `TreeObject.emptyTree` âž” `TreeObject.empty_tree` In many places: - `getObject` âž” `get_object` - `writeToStream` âž” `write_to_stream` - `readFromStream` âž” `read_from_stream` PdfReader class: - `reader.getPage(pageNumber)` âž” `reader.pages[page_number]` - `reader.getNumPages()` / `reader.numPages` âž” `len(reader.pages)` - `getDocumentInfo` âž” `metadata` - `flattenedPages` attribute âž” `flattened_pages` - `resolvedObjects` attribute âž” `resolved_objects` - `xrefIndex` attribute âž” `xref_index` - `getNamedDestinations` / `namedDestinations` attribute âž” `named_destinations` - `getPageLayout` / `pageLayout` âž” `page_layout` attribute - `getPageMode` / `pageMode` âž” `page_mode` attribute - `getIsEncrypted` / `isEncrypted` âž” `is_encrypted` attribute - `getOutlines` âž” `get_outlines` - `readObjectHeader` âž” `read_object_header` - `cacheGetIndirectObject` âž” `cache_get_indirect_object` - `cacheIndirectObject` âž” `cache_indirect_object` - `getDestinationPageNumber` âž” `get_destination_page_number` - `readNextEndLine` âž” `read_next_end_line` - `_zeroXref` âž” `_zero_xref` - `_authenticateUserPassword` âž” `_authenticate_user_password` - `_pageId2Num` attribute âž” `_page_id2num` - `_buildDestination` âž” `_build_destination` - `_buildOutline` âž” `_build_outline` - `_getPageNumberByIndirect(indirectRef)` âž” `_get_page_number_by_indirect(indirect_ref)` - `_getObjectFromStream` âž” `_get_object_from_stream` - `_decryptObject` âž” `_decrypt_object` - `_flatten(..., indirectRef)` âž” `_flatten(..., indirect_ref)` - `_buildField` âž” `_build_field` - `_checkKids` âž” `_check_kids` - `_writeField` âž” `_write_field` - `_write_field(..., fieldAttributes)` âž” `_write_field(..., field_attributes)` - `_read_xref_subsections(..., getEntry, ...)` âž” `_read_xref_subsections(..., get_entry, ...)` PdfWriter class: - `writer.getPage(pageNumber)` âž” `writer.pages[page_number]` - `writer.getNumPages()` âž” `len(writer.pages)` - `addMetadata` âž” `add_metadata` - `addPage` âž” `add_page` - `addBlankPage` âž” `add_blank_page` - `addAttachment(fname, fdata)` âž” `add_attachment(filename, data)` - `insertPage` âž” `insert_page` - `insertBlankPage` âž” `insert_blank_page` - `appendPagesFromReader` âž” `append_pages_from_reader` - `updatePageFormFieldValues` âž” `update_page_form_field_values` - `cloneReaderDocumentRoot` âž” `clone_reader_document_root` - `cloneDocumentFromReader` âž” `clone_document_from_reader` - `getReference` âž” `get_reference` - `getOutlineRoot` âž” `get_outline_root` - `getNamedDestRoot` âž” `get_named_dest_root` - `addBookmarkDestination` âž” `add_bookmark_destination` - `addBookmarkDict` âž” `add_bookmark_dict` - `addBookmark` âž” `add_bookmark` - `addNamedDestinationObject` âž” `add_named_destination_object` - `addNamedDestination` âž” `add_named_destination` - `removeLinks` âž” `remove_links` - `removeImages(ignoreByteStringObject)` âž” `remove_images(ignore_byte_string_object)` - `removeText(ignoreByteStringObject)` âž” `remove_text(ignore_byte_string_object)` - `addURI` âž” `add_uri` - `addLink` âž” `add_link` - `getPage(pageNumber)` âž” `get_page(page_number)` - `getPageLayout / setPageLayout / pageLayout` âž” `page_layout attribute` - `getPageMode / setPageMode / pageMode` âž” `page_mode attribute` - `_addObject` âž” `_add_object` - `_addPage` âž” `_add_page` - `_sweepIndirectReferences` âž” `_sweep_indirect_references` PdfMerger class - `__init__` parameter: `strict=True` âž” `strict=False` (the `PdfFileMerger` still has the old default) - `addMetadata` âž” `add_metadata` - `addNamedDestination` âž” `add_named_destination` - `setPageLayout` âž” `set_page_layout` - `setPageMode` âž” `set_page_mode` Page class: - `artBox` / `bleedBox` / `cropBox` / `mediaBox` / `trimBox` âž” `artbox` / `bleedbox` / `cropbox` / `mediabox` / `trimbox` - `getWidth`, `getHeight ` âž” `width` / `height` - `getLowerLeft_x` / `getUpperLeft_x` âž” `left` - `getUpperRight_x` / `getLowerRight_x` âž” `right` - `getLowerLeft_y` / `getLowerRight_y` âž” `bottom` - `getUpperRight_y` / `getUpperLeft_y` âž” `top` - `getLowerLeft` / `setLowerLeft` âž” `lower_left` property - `upperRight` âž” `upper_right` - `mergePage` âž” `merge_page` - `rotateClockwise` / `rotateCounterClockwise` âž” `rotate_clockwise` - `_mergeResources` âž” `_merge_resources` - `_contentStreamRename` âž” `_content_stream_rename` - `_pushPopGS` âž” `_push_pop_gs` - `_addTransformationMatrix` âž” `_add_transformation_matrix` - `_mergePage` âž” `_merge_page` XmpInformation class: - `getElement(..., aboutUri, ...)` âž” `get_element(..., about_uri, ...)` - `getNodesInNamespace(..., aboutUri, ...)` âž” `get_nodes_in_namespace(..., aboutUri, ...)` - `_getText` âž” `_get_text` utils.py: - `matrixMultiply` âž” `matrix_multiply - `RC4_encrypt` is moved to the security module ## Parameter Names * `PdfWriter.get_page`: `pageNumber` âž” `page_number` * `PyPDF2.filters` (all classes): `decodeParms` âž” `decode_parms` * `PyPDF2.filters` (all classes): `decodeStreamData` âž” `decode_stream_data` * `pagenum` âž” `page_number` * `PdfMerger.merge`: `position` âž” `page_number` * `PdfWriter.add_outline_item_destination`: `dest` âž” `page_destination` * `PdfWriter.add_named_destination_object`: `dest` âž” `page_destination` * `PdfWriter.encrypt`: `user_pwd` âž” `user_password` * `PdfWriter.encrypt`: `owner_pwd` âž” `owner_password` ## Deprecations A few classes / functions were deprecated without replacement: * `PyPDF2.utils.ConvertFunctionsToVirtualList` * `PyPDF2.utils.formatWarning` * `PyPDF2.isInt(obj)`: Use `instance(obj, int)` instead * `PyPDF2.u_(s)`: Use `s` directly * `PyPDF2.chr_(c)`: Use `chr(c)` instead * `PyPDF2.barray(b)`: Use `bytearray(b)` instead * `PyPDF2.isBytes(b)`: Use `instance(b, type(bytes()))` instead * `PyPDF2.xrange_fn`: Use `range` instead * `PyPDF2.string_type`: Use `str` instead * `PyPDF2.isString(s)`: Use `instance(s, str)` instead * `PyPDF2._basestring`: Use `str` instead * `b_(...)` was removed. 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It can be that pypdf can do the operations you want on PDF 2.0 files without fully supporting all features of PDF 2.0. ## PDF Feature Support by pypdf | Feature | PDF Version | pypdf Support | |--------------------------------|:-----------:|:-------------:| | CMaps | 1.4 | âś… | | Transparent Graphics | 1.4 | âś… | | Content Stream Compression | 1.5 | âś… | | Cross-reference Streams | 1.5 | âť“ | | Object Streams | 1.5 | âś… | | Optional Content Groups (OCGs) | 1.5 | âť“ | | AES Encryption | 1.6 | âś… | See [History of PDF](https://en.wikipedia.org/wiki/History_of_PDF) for more features. Some PDF features are not supported by pypdf, but other libraries can be used for them: * [pyHanko](https://pyhanko.readthedocs.io/en/latest/index.html): Cryptographically sign a PDF ([#302](https://github.com/py-pdf/pypdf/issues/302)) * [camelot-py](https://pypi.org/project/camelot-py/): Table Extraction ([#231](https://github.com/py-pdf/pypdf/issues/231)) pypdf-6.1.2/docs/user/pdfa-compliance.md000066400000000000000000000112271507516550200201250ustar00rootroot00000000000000# PDF/A Compliance PDF/A is a specialized, ISO-standardized version of the Portable Document Format (PDF) specifically designed for the long-term preservation and archiving of electronic documents. It ensures that files remain accessible, readable, and true to their original appearance by embedding all necessary fonts, images, and metadata within the document itself. By adhering to strict guidelines and minimizing dependencies on external resources or proprietary software, PDF/A ensures the consistent and reliable reproduction of content, safeguarding it against future technological changes and obsolescence. ## PDF/A Versions * **PDF/A-1**: Based on PDF 1.4, PDF/A-1 is the first version of the standard and is divided into two levels: PDF/A-1a (Level A, ensuring accessibility) and PDF/A-1b (Level B, ensuring visual preservation). * **Level B** (Basic): Ensures visual preservation and basic requirements for archiving. * **Level A** (Accessible): Everything from level B, but includes additional requirements for accessibility, such as tagging, Unicode character mapping, and logical structure. * **PDF/A-2**: Based on PDF 1.7 (ISO 32000-1), PDF/A-2 adds features and improvements over PDF/A-1, while maintaining compatibility with PDF/A-1b (Level B) documents. * **Level B** (Basic): Like PDF/A-1b, but support for PDF 1.7 features such as transparency layers. * **Level U** (Unicode): Ensures Unicode mapping without the full accessibility requirements of PDF/A-1a (Level A). * **Level A** (Accessible): Similar to PDF/A-1a * **PDF/A-3**: Based on PDF 1.7 (ISO 32000-1), PDF/A-3 is similar to PDF/A-2 but allows the embedding of non-PDF/A files as attachments, enabling the archiving of source or supplementary data alongside the PDF/A document. This is interesting for invoices which can add XML files. * **PDF/A-4**: Based on PDF 2.0 (ISO 32000-2), PDF/A-4 introduces new features and improvements for better archiving and accessibility. The previous levels are replaced by PDF/A-4f (ensuring visual preservation and allowing attachments) and PDF/A-4e (Engineering, allows 3D content). ## PDF/A-1b In contrast to other PDF documents, PDF/A-1b documents must fulfill those requirements: * **MarkInfo Object**: The MarkInfo object is a dictionary object within a PDF/A file that provides information about the logical structure and tagging of the document. The MarkInfo object indicates whether the document is tagged, contains optional content, or has a structure tree that describes the logical arrangement of content such as headings, paragraphs, lists, and tables. By including the MarkInfo object, PDF/A ensures that electronic documents are accessible to users with disabilities, such as those using screen readers or other assistive technologies. * **Embedded fonts**: All fonts used in the document must be embedded to ensure consistent text rendering across different devices and systems. * **Color Spaces**: DeviceRGB is a device-dependent color space that relies on the specific characteristics of the output device, which can lead to inconsistent color rendering across various devices. To achieve accurate and consistent color representation, PDF/A requires the use of device-independent color spaces, such as ICC-based color profiles. * **XMP (Extensible Metadata Platform) metadata**: XMP metadata provides a standardized and extensible way to store essential information about a document and its properties. XMP metadata is an XML-based format embedded directly within a PDF/A file. It contains various types of information, such as document title, author, creation and modification dates, keywords, and copyright information, as well as PDF/A-specific details like conformance level and OutputIntent. ## Validation [VeraPDF](https://docs.verapdf.org/install/) is the go-to PDF/A validator. There are several online validators that allow you to simply upload the document: * [pdfen.com](https://www.pdfen.com/pdf-a-validator) * [avepdf.com](https://avepdf.com/pdfa-validation) : Gives an error report * [pdfa.org](https://pdfa.org/pdfa-online-verification-service/) * [visual-paradigm.com](https://online.visual-paradigm.com/de/online-pdf-editor/pdfa-validator/) - can convert the PDF to a PDF/A * [pdf2go.com](https://www.pdf2go.com/validate-pdfa) * [slub-dresden.de](https://www.slub-dresden.de/veroeffentlichen/dissertationen-habilitationen/elektronische-veroeffentlichung/slub-pdfa-validator) links to relevant parts in the specification. ## pypdf and PDF/A At the moment, pypdf does not make any guarantees regarding PDF/A. 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ŤFăú2O…Ăá°Űí===·oßîěěĽ~ýúµk×.]şTWWWSSÓÚÚzçÎť!łŰí<{öěîÝ»ź|ňI)ß,čONR¨TŞ_˙ú׍ć•W^ämś&“©şşşşşZůRŁŃčőúđđđŔŔ@ç›BoßľÝŐŐe6›oÝşuóćÍQľ&ŁˇˇaĺĘ•Ď<óĚĎ~öłŃܸ9I!„P«Ő/ľřbLLĚĆŤoÝşĺÎMl6›Á`0 ˛f„Ýnßżż"99Ů ‡`Ľ‘đZ '•J•——WVVćüëç÷”'žxbË–-ľž€±IfR(233˙ůĎ._ľ\­–ç#öĐCíŰ·ĎőŁ±€DůW?..®´´ôŔ ž¸˙áúŢ÷ľ÷á‡FFFúzĆ,O= ŐjsrrŞŞŞ¶lŮ档¸#**ęСC‰‰‰>ś€1ĎłĎMÄÄÄl۶­¶¶vÓ¦Mz˝ŢŁÇPHHČűďż˙ýďßű‡`\ńĆËâăăwěŘQ[[űú믧¦¦xá B€€€]»v-Z´Č;‡`<óŢ+(cccő«_UVVVTTĽúę«?řÁ<ÝëÖ­óč!€BÚçR¸I§ÓĄ§§§§§655UTTTTTTWW_˝zµµµu¸>T­VGDD ř±ÜĎ?˙üď~÷»ţĘ <ÁŰIá¤V«ďż˙ţU«V­ZµĘn·›L&ŁŃřÝwß]ż~˝ˇˇáĆŤ·nÝęîî6™Lʇ|k4šĐĐШ¨¨ŘŘŘřřřÄÄĤ¤$ŁŃřđĂ÷ů đ%K–ěÚµ‹žŔk|–®ÔjuXXXXXŘ´iÓ†{[˝^ŻÓé\?±{ćĚ™űöí ’:#Ě=ôiT#3qâÄç— }ôQtt´G`ňű¤B8?˙[ůŠ{óăŔŰĆNRL0a˙ţý=ôŻÇ`< I‘””¤Őjßx㍟üä'ľž€qj,$ĹÔ©S7oŢüÜsĎůzĆŻ{âŁôÔSOMś8ńžúçŚ7c!)˘˘˘|=ă˙g$ )€n=ńˇR©˛˛˛<=ŠŘíöµk×úz Ć ·’bőË)žžĂk:ÄçŰ˙çs_OŔXŁ2uwůzŕ÷x-€¤@’H@R H I$ )€$€¤@’H@R H I$ )€$€¤ü/Ëm‡DIEND®B`‚pypdf-6.1.2/docs/user/post-processing-in-text-extraction.md000066400000000000000000000067551507516550200240200ustar00rootroot00000000000000# Post-Processing of Text Extraction Post-processing can recognizably improve the results of text extraction. It is, however, outside the scope of pypdf itself. Hence, the library will not give any direct support for it. It is a natural language processing (NLP) task. This page lists a few examples of what can be done as well as a community recipe that can be used as a general purpose post-processing step. If you know more about the specific domain of your documents, e.g., the language, it is likely that you can find custom solutions that work better in your context. ## Ligature Replacement ```python def replace_ligatures(text: str) -> str: ligatures = { "ff": "ff", "ď¬": "fi", "fl": "fl", "ď¬": "ffi", "ffl": "ffl", "ſt": "ft", "st": "st", # "Ꜳ": "AA", # "Æ": "AE", "ęśł": "aa", } for search, replace in ligatures.items(): text = text.replace(search, replace) return text ``` ## Dehyphenation Hyphens are used to break words up so that the appearance of the page is nicer. ```python from typing import List def remove_hyphens(text: str) -> str: """ This fails for: * Natural dashes: well-known, self-replication, use-cases, non-semantic, Post-processing, Window-wise, viewpoint-dependent * Trailing math operands: 2 - 4 * Names: Lopez-Ferreras, VGG-19, CIFAR-100 """ lines = [line.rstrip() for line in text.split("\n")] # Find dashes line_numbers = [] for line_no, line in enumerate(lines[:-1]): if line.endswith("-"): line_numbers.append(line_no) # Replace for line_no in line_numbers: lines = dehyphenate(lines, line_no) return "\n".join(lines) def dehyphenate(lines: List[str], line_no: int) -> List[str]: next_line = lines[line_no + 1] word_suffix = next_line.split(" ")[0] lines[line_no] = lines[line_no][:-1] + word_suffix lines[line_no + 1] = lines[line_no + 1][len(word_suffix) :] return lines ``` ## Header/Footer Removal The following header/footer removal has several drawbacks: * False-positives, e.g., for the first page when there is a date like 2024. * False-negatives in many cases: * Dynamic part, e.g., page label is in the header. * Even/odd pages have different headers. * Some pages, e.g., the first one or chapter pages, do not have a header. ```python def remove_footer(extracted_texts: list[str], page_labels: list[str]): def remove_page_labels(extracted_texts, page_labels): processed = [] for text, label in zip(extracted_texts, page_labels): text_left = text.lstrip() if text_left.startswith(label): text = text_left[len(label) :] text_right = text.rstrip() if text_right.endswith(label): text = text_right[: -len(label)] processed.append(text) return processed extracted_texts = remove_page_labels(extracted_texts, page_labels) return extracted_texts ``` ## Other ideas * Whitespaces in units: Between a number and its unit should be a space. ([source](https://tex.stackexchange.com/questions/20962/should-i-put-a-space-between-a-number-and-its-unit)). That means: 42 ms, 42 GHz, 42 GB. * Percent: English style guides prescribe writing the percent sign following the number without any space between (e.g., 50%). * Whitespaces before dots: Should typically be removed. * Whitespaces after dots: Should typically be added. pypdf-6.1.2/docs/user/reading-pdf-annotations.md000066400000000000000000000036201507516550200216140ustar00rootroot00000000000000# Reading PDF Annotations PDF 2.0 defines the following annotation types: * Text * Link * FreeText * Line * Square * Circle * Polygon * PolyLine * Highlight * Underline * Squiggly * StrikeOut * Caret * Stamp * Ink * Popup * FileAttachment * Sound * Movie * Screen * Widget * PrinterMark * TrapNet * Watermark * 3D * Redact * Projection * RichMedia In general, annotations can be read like this: ```python from pypdf import PdfReader reader = PdfReader("annotated.pdf") for page in reader.pages: if "/Annots" in page: for annotation in page["/Annots"]: obj = annotation.get_object() print({"subtype": obj["/Subtype"], "location": obj["/Rect"]}) ``` Examples of reading three of the most common annotations: ## Text ```python from pypdf import PdfReader reader = PdfReader("example.pdf") for page in reader.pages: if "/Annots" in page: for annotation in page["/Annots"]: subtype = annotation.get_object()["/Subtype"] if subtype == "/Text": print(annotation.get_object()["/Contents"]) ``` ## Highlights ```python from pypdf import PdfReader reader = PdfReader("example.pdf") for page in reader.pages: if "/Annots" in page: for annotation in page["/Annots"]: subtype = annotation.get_object()["/Subtype"] if subtype == "/Highlight": coords = annotation.get_object()["/QuadPoints"] x1, y1, x2, y2, x3, y3, x4, y4 = coords ``` ## Attachments ```python from pypdf import PdfReader reader = PdfReader("example.pdf") attachments = {} for page in reader.pages: if "/Annots" in page: for annotation in page["/Annots"]: subtype = annotation.get_object()["/Subtype"] if subtype == "/FileAttachment": fileobj = annotation.get_object()["/FS"] attachments[fileobj["/F"]] = fileobj["/EF"]["/F"].get_data() ``` pypdf-6.1.2/docs/user/robustness.md000066400000000000000000000024701507516550200173120ustar00rootroot00000000000000# Robustness and strict=False PDF is [specified in various versions](https://pdfa.org/resource/pdf-specification-archive/). The specification of PDF 2.0 has 1003 pages. This length makes it hard to get everything right. As a consequence, a lot of PDF files are not strictly following the specification. If a PDF file does not follow the specification, it is not always possible to be certain what the intended effect would be. Think of the following broken Python code as an example: ```python # Broken function (foo, bar): # Potentially intended: def function(foo, bar): ... # Also possible: function = (foo, bar) ``` Writing a parser, you can go two paths: Either you try to be forgiving and try to figure out what the user intended, or you are strict and just tell the user that they should fix their stuff. pypdf gives you the option to be strict or not. pypdf has two core objects: * {class}`~pypdf.PdfReader` * {class}`~pypdf.PdfWriter` Only the PdfReader has a `strict` parameter, since presumably you do not want to write a non-conforming PDF. Choosing `strict=True` means that pypdf will raise an exception if a PDF does not follow the specification. Choosing `strict=False` means that pypdf will try to be forgiving and do something reasonable, but it will log a warning message. 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@‰Fef);±ÜVbb±GâX5_6“°Qqc–tvNN› ZŁq}Z‚PśL$ŞUu}d+¨¬,e@­Vł™÷đźJÂ?ňb3)Ű·ý›~íFÚJ„=şB[ @ ¦Ő*?g»­ôö–_8m%¸łŽYŇŮ99myĎEŠ‰Duč,(™ŚĆś€öÔ›·lć$|?QK„#vŔÍ}pĚRżvCÓ§=»A[ @Ie2e·ëČv[YÇ_qć´•ŕţŠî,iµZżť‘„!7Š‘ȦQTNh8ý*•Íśd“FŠ¤pr#”E˙°ÖoJ`hI¸ wŹŇ9Ă’¦µóâĚÝ㺤ęŇ‹zřÍŚĽđ0ů»ŮĚŔEĚł¤uşśÖô»,×g#IŹ3GńO޸>2×ňNťQG C‘Í›ŠFŹŕućş"\LŐg éňU63 şv–¬ü™ÍŚśTÄĄaŰŻŚ´• ľčU*ŰJ„nĹjË/L×˝zTŤ(IDATn¨ż©ęŮ/ďŘIdĂ™ě”ęácYn+ůýú@[ %Î˙|ŽŢňÖ7ŕIEND®B`‚pypdf-6.1.2/docs/user/streaming-data.md000066400000000000000000000041641507516550200200050ustar00rootroot00000000000000# Streaming Data with pypdf In some cases, you might want to avoid saving things explicitly as a file to disk, e.g. when you want to store the PDF in a database or AWS S3. pypdf supports streaming data to a file-like object: ```python from io import BytesIO # Prepare example with open("example.pdf", "rb") as fh: bytes_stream = BytesIO(fh.read()) # Read from bytes_stream reader = PdfReader(bytes_stream) # Write to bytes_stream writer = PdfWriter() with BytesIO() as bytes_stream: writer.write(bytes_stream) ``` ## Writing a PDF directly to AWS S3 Suppose you want to manipulate a PDF and write it directly to AWS S3 without having to write the document to a file first. We have the original PDF in `raw_bytes_data` as `bytes` and want to set `my-secret-password`: ```python from io import BytesIO import boto3 from pypdf import PdfReader, PdfWriter reader = PdfReader(BytesIO(raw_bytes_data)) writer = PdfWriter() # Add all pages to the writer for page in reader.pages: writer.add_page(page) # Add a password to the new PDF writer.encrypt("my-secret-password") # Save the new PDF to a file with BytesIO() as bytes_stream: writer.write(bytes_stream) bytes_stream.seek(0) s3 = boto3.client("s3") s3.write_get_object_response( Body=bytes_stream, RequestRoute=request_route, RequestToken=request_token ) ``` ## Reading PDFs directly from cloud services One option is to first download the file and then pass the local file path to `PdfReader`. Another option is to get a byte stream. For AWS S3 it works like this: ```python from io import BytesIO import boto3 from pypdf import PdfReader s3 = boto3.client("s3") obj = s3.get_object(Body=csv_buffer.getvalue(), Bucket="my-bucket", Key="my/doc.pdf") reader = PdfReader(BytesIO(obj["Body"].read())) ``` To use with Google Cloud storage: ```python from io import BytesIO from google.cloud import storage # os.environ["GOOGLE_APPLICATION_CREDENTIALS"] must be set storage_client = storage.Client() blob = storage_client.bucket("my-bucket").blob("mydoc.pdf") file_stream = BytesIO() blob.download_to_file(file_stream) reader = PdfReader(file_stream) ``` pypdf-6.1.2/docs/user/suppress-warnings.md000066400000000000000000000054211507516550200206140ustar00rootroot00000000000000# Exceptions, Warnings, and Log messages pypdf makes use of three mechanisms to show if something went wrong: * **Exceptions** are error cases that pypdf users should explicitly handle. In the `strict=True` mode, most log messages with the warning level will become exceptions. This can be useful in applications where you can require a user to fix the broken PDF. * **Warnings** are avoidable issues, such as using deprecated classes / functions / parameters. Another example is missing capabilities of pypdf. In those cases, pypdf users should adjust their code. Warnings are issued by the `warnings` module - those are different from the log-level "warning." * **Log messages** are informative messages that can be used for post-mortem analysis. Most of the time, users can ignore them. They come in different *levels*, such as info / warning / error indicating the severity. Examples are non-standard compliant PDF files which pypdf can deal with or a missing implementation that leads to a part of the text not being extracted. ## Exceptions Exceptions need to be caught if you want to handle them. For example, you could want to read the text from a PDF as a part of a search function. Most PDF files do not follow the specification. In this case, pypdf needs to guess which kinds of mistakes were potentially done when the PDF file was created. See [the robustness page](robustness.md) for the related issues. As a user, you likely do not care about it. If it is readable in any way, you want the text. You might use pdfminer.six as a fallback and do this: ```python from pypdf import PdfReader from pdfminer.high_level import extract_text as fallback_text_extraction text = "" try: reader = PdfReader("example.pdf") for page in reader.pages: text += page.extract_text() except Exception as exc: text = fallback_text_extraction("example.pdf") ``` You could also capture [`pypdf.errors.PyPdfError`](https://github.com/py-pdf/pypdf/blob/main/pypdf/errors.py) if you prefer something more specific. ## Warnings The [`warnings` module](https://docs.python.org/3/library/warnings.html) allows you to ignore warnings: ```python import warnings warnings.filterwarnings("ignore") ``` In many cases, you actually want to start Python with the `-W` flag so that you see all warnings. This is especially true for Continuous Integration (CI). ## Log messages Log messages can be noisy in some cases. pypdf hopefully has a reasonable level of log messages, but you can reduce which types of messages you want to see: ```python import logging logger = logging.getLogger("pypdf") logger.setLevel(logging.ERROR) ``` The [`logging` module](https://docs.python.org/3/library/logging.html#logging-levels) defines six log levels: * CRITICAL * ERROR * WARNING * INFO * DEBUG * NOTSET pypdf-6.1.2/docs/user/text-annotation.png000066400000000000000000000555101507516550200204260ustar00rootroot00000000000000‰PNG  IHDR?Č÷ěĚ‚sBITŰáOŕtEXtSoftwaremate-screenshotČ–đJ IDATxśěÝg|ŐŢŔń˙ěn )„ ”ĐH©ŇK¤‰ąRĄ "\0¨€(˝Ëµ€¤‰R ” „H % @„ôlvgžIäŕďűŽŮŮÝcül2ż™sf5Ă0rxälDĽÍČŘ®YÜ˝Ş5íÍţ}w’” +úµÜýŔщŐů<d%fŽ•táű±ť«–©ńęűłWď=oT~mäg+¶‡ÝŽŽąsăüˇď>l®oŐ˛jý_­űĽ[›«BRl6[6ŽWż´nŮgbłq÷ĺ¨Á€ç‹fĆ˙Ţ řç°] x§k˙ÇctŃĽÚŚ[¶đý–Ĺ˙:'Ěvë—yCzŽ ¸’bĂ cON­ť]×^Rv ,ÓéסgŽ.oΦ!äĐÁ€ç ×^€č77ľýrŹůÇctŃrUî˙ÝM=*]DÄâYřęť_´÷Ěź!ýÖ…KQzvŹ"]Ž xÎä€#/ 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Note that the `/ViewerPreferences` dictionary does not exist by default. If it is not already present, it must be created by calling the {func}`~pypdf.PdfWriter.create_viewer_preferences` method. If viewer preferences exist in a PDF file being read with {class}`~pypdf.PdfReader`, you can access them as properties of {attr}`~pypdf.PdfReader.viewer_preferences`. Otherwise, the {attr}`~pypdf.PdfReader.viewer_preferences` property will be set to `None`. ## Example ```python from pypdf import PdfWriter from pypdf.generic import ArrayObject, NumberObject writer = PdfWriter() writer.create_viewer_preferences() # /HideToolbar writer.viewer_preferences.hide_toolbar = True # /HideMenubar writer.viewer_preferences.hide_menubar = True # /HideWindowUI writer.viewer_preferences.hide_windowui = True # /FitWindow writer.viewer_preferences.fit_window = True # /CenterWindow writer.viewer_preferences.center_window = True # /DisplayDocTitle writer.viewer_preferences.display_doctitle = True # /NonFullScreenPageMode writer.viewer_preferences.non_fullscreen_pagemode = "/UseNone" # default writer.viewer_preferences.non_fullscreen_pagemode = "/UseOutlines" writer.viewer_preferences.non_fullscreen_pagemode = "/UseThumbs" writer.viewer_preferences.non_fullscreen_pagemode = "/UseOC" # /Direction writer.viewer_preferences.direction = "/L2R" # default writer.viewer_preferences.direction = "/R2L" # /ViewArea writer.viewer_preferences.view_area = "/CropBox" # /ViewClip writer.viewer_preferences.view_clip = "/CropBox" # /PrintArea writer.viewer_preferences.print_area = "/CropBox" # /PrintClip writer.viewer_preferences.print_clip = "/CropBox" # /PrintScaling writer.viewer_preferences.print_scaling = "/None" writer.viewer_preferences.print_scaling = "/AppDefault" # default according to PDF spec # /Duplex writer.viewer_preferences.duplex = "/Simplex" writer.viewer_preferences.duplex = "/DuplexFlipShortEdge" writer.viewer_preferences.duplex = "/DuplexFlipLongEdge" # /PickTrayByPDFSize writer.viewer_preferences.pick_tray_by_pdfsize = True # /PrintPageRange writer.viewer_preferences.print_pagerange = ArrayObject( [NumberObject("1"), NumberObject("10"), NumberObject("20"), NumberObject("30")] ) # /NumCopies writer.viewer_preferences.num_copies = 2 for i in range(40): writer.add_blank_page(10, 10) with open("output.pdf", "wb") as output_stream: writer.write(output_stream) ``` The names beginning with a slash character are part of the PDF file format. 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.Ç•3ćjv·Ž‡U«¦hÍ*vËŽjPłu»jń2j÷šŮZ˛ăÇ_.tşâý”§îրݸ‘äHłµĚŔŔŔŕ™8řq‹ýwĂŮć2gOgĚĺĘ‹%Zą”7ě3wëáxđÔ4YT´ęÇĺ¤FC낲’eđÇŽo^‡H(Ž«lńF\ŤBQüAg1—ąCKNcĚeŹĹÁ{̲¨hěĆ-6h;ĽąäŘA&'ve$U‹k~Űán=ś«NmÁôoą˝ş—fă’2™zĺ/ş“§Ä›×—yž»wźxö‚Ő× šľ+%źô#Î=nA 6[Ľ.ŽŰ«‡»ő`````°†#-fÝ™sŠ1_8޵ŇŢËnýžłĄ0¸ő/ëŐ«~çĺˇt+¬zuřŁGr:uD«… ń§Ďµ ´űRy>_ôËJnĎnîSłň]ż)űl8čôîVďăĐ5Ü­C8ÎbĆń’OúŕNŽüĎíŐ]üëZ§Š`p/Ú„Ę9 sL  Ď­ŠŠâ)O,$ GQáÜü •-ôž‡ ?}V>a˛Ł"™”v«pɡ˝Ŕf»[†˛qŬ=pX9u–Cš*ÇűüIVíZΕÂŕnôg/(&}KŞÔîVÄťđ†ý°ŘLjG˘ŢŻţqąĽÄ@ř_Ž«|I|*1˛őú⎟™hŞtřăÇ0°Ţđ¤důč‰NOéŮp:´o^‡ĹîV¤’ Š]ćQä¸ńćŤÜÎÝ­ üî ËXDűIEND®B`‚pypdf-6.1.2/make_release.py000066400000000000000000000234371507516550200156500ustar00rootroot00000000000000"""Internal tool to update the CHANGELOG.""" import json import subprocess import urllib.request from dataclasses import dataclass from datetime import datetime, timezone GH_ORG = "py-pdf" GH_PROJECT = "pypdf" VERSION_FILE_PATH = "pypdf/_version.py" CHANGELOG_FILE_PATH = "CHANGELOG.md" @dataclass(frozen=True) class Change: """Capture the data of a git commit.""" commit_hash: str prefix: str message: str author: str author_login: str def main(changelog_path: str) -> None: """ Create a changelog. Args: changelog_path: The location of the CHANGELOG file """ changelog = get_changelog(changelog_path) git_tag = get_most_recent_git_tag() changes, changes_with_author = get_formatted_changes(git_tag) if changes == "": print("No changes") return new_version = version_bump(git_tag) new_version = get_version_interactive(new_version, changes) adjust_version_py(new_version) today = datetime.now(tz=timezone.utc) header = f"## Version {new_version}, {today:%Y-%m-%d}\n" url = f"https://github.com/{GH_ORG}/{GH_PROJECT}/compare/{git_tag}...{new_version}" trailer = f"\n[Full Changelog]({url})\n\n" new_entry = header + changes + trailer print(new_entry) write_commit_msg_file(new_version, changes_with_author + trailer) # write_release_msg_file(new_version, changes_with_author + trailer, today) # Make the script idempotent by checking if the new entry is already in the changelog if new_entry in changelog: print("Changelog is already up-to-date!") return new_changelog = "# CHANGELOG\n\n" + new_entry + strip_header(changelog) write_changelog(new_changelog, changelog_path) print_instructions(new_version) def print_instructions(new_version: str) -> None: """Print release instructions.""" print("=" * 80) print(f"â‘ {VERSION_FILE_PATH} was adjusted to '{new_version}'") print(f"â‘ {CHANGELOG_FILE_PATH} was adjusted") print() print("Now run:") print(" git commit -eF RELEASE_COMMIT_MSG.md") print(" git push") def adjust_version_py(version: str) -> None: """Adjust the __version__ string.""" with open(VERSION_FILE_PATH, "w") as fp: fp.write(f'__version__ = "{version}"\n') def get_version_interactive(new_version: str, changes: str) -> str: """Get the new __version__ interactively.""" from rich.prompt import Prompt # noqa: PLC0415 print("The changes are:") print(changes) orig = new_version new_version = Prompt.ask("New semantic version", default=orig) while not is_semantic_version(new_version): new_version = Prompt.ask( "That was not a semantic version. Please enter a semantic version", default=orig, ) return new_version def is_semantic_version(version: str) -> bool: """Check if the given version is a semantic version.""" # This doesn't cover the edge-cases like pre-releases if version.count(".") != 2: return False try: return bool([int(part) for part in version.split(".")]) except Exception: return False def write_commit_msg_file(new_version: str, commit_changes: str) -> None: """ Write a file that can be used as a commit message. Like this: git commit -eF RELEASE_COMMIT_MSG.md && git push """ with open("RELEASE_COMMIT_MSG.md", "w") as fp: fp.write(f"REL: {new_version}\n\n") fp.write("## What's new\n") fp.write(commit_changes) def write_release_msg_file( new_version: str, commit_changes: str, today: datetime ) -> None: """ Write a file that can be used as a git tag message. Like this: git tag -eF RELEASE_TAG_MSG.md && git push """ with open("RELEASE_TAG_MSG.md", "w") as fp: fp.write(f"Version {new_version}, {today:%Y-%m-%d}\n\n") fp.write("## What's new\n") fp.write(commit_changes) def strip_header(md: str) -> str: """Remove the 'CHANGELOG' header.""" return md.removeprefix("# CHANGELOG").lstrip() def version_bump(git_tag: str) -> str: """ Increase the patch version of the git tag by one. Args: git_tag: Old version tag Returns: The new version where the patch version is bumped. """ # just assume a patch version change major, minor, patch = git_tag.split(".") return f"{major}.{minor}.{int(patch) + 1}" def get_changelog(changelog_path: str) -> str: """ Read the changelog. Args: changelog_path: Path to the CHANGELOG file Returns: Data of the CHANGELOG """ with open(changelog_path, encoding="utf-8") as fh: return fh.read() def write_changelog(new_changelog: str, changelog_path: str) -> None: """ Write the changelog. Args: new_changelog: Contents of the new CHANGELOG changelog_path: Path where the CHANGELOG file is """ with open(changelog_path, "w", encoding="utf-8") as fh: fh.write(new_changelog) def get_formatted_changes(git_tag: str) -> tuple[str, str]: """ Format the changes done since the last tag. Args: git_tag: the reference tag Returns: Changes done since git_tag """ commits = get_git_commits_since_tag(git_tag) # Group by prefix grouped = {} for commit in commits: if commit.prefix not in grouped: grouped[commit.prefix] = [] grouped[commit.prefix].append( {"msg": commit.message, "author": commit.author_login} ) # Order prefixes order = [ "SEC", "DEP", "ENH", "PI", "BUG", "ROB", "DOC", "DEV", "CI", "MAINT", "TST", "STY", ] abbrev2long = { "SEC": "Security", "DEP": "Deprecations", "ENH": "New Features", "BUG": "Bug Fixes", "ROB": "Robustness", "DOC": "Documentation", "DEV": "Developer Experience", "CI": "Continuous Integration", "MAINT": "Maintenance", "TST": "Testing", "STY": "Code Style", "PI": "Performance Improvements", } # Create output output = "" output_with_user = "" for prefix in order: if prefix not in grouped: continue tmp = f"\n### {abbrev2long[prefix]} ({prefix})\n" # header output += tmp output_with_user += tmp for commit in grouped[prefix]: output += f"- {commit['msg']}\n" output_with_user += f"- {commit['msg']} by @{commit['author']}\n" del grouped[prefix] if grouped: output += "\n### Other\n" output_with_user += "\n### Other\n" for prefix, commits in grouped.items(): for commit in commits: output += f"- {prefix}: {commit['msg']}\n" output_with_user += ( f"- {prefix}: {commit['msg']} by @{commit['author']}\n" ) return output, output_with_user def get_most_recent_git_tag() -> str: """ Get the git tag most recently created. Returns: Most recently created git tag. """ return subprocess.check_output( ["git", "describe", "--tag", "--abbrev=0"], stderr=subprocess.STDOUT, text=True ).strip() def get_author_mapping(line_count: int) -> dict[str, str]: """ Get the authors for each commit. Args: line_count: Number of lines from Git log output. Used for determining how many commits to fetch. Returns: A mapping of long commit hashes to author login handles. """ per_page = min(line_count, 100) page = 1 mapping: dict[str, str] = {} for _ in range(0, line_count, per_page): with urllib.request.urlopen( f"https://api.github.com/repos/{GH_ORG}/{GH_PROJECT}/commits?per_page={per_page}&page={page}" ) as response: commits = json.loads(response.read()) page += 1 for commit in commits: mapping[commit["sha"]] = commit["author"]["login"] return mapping def get_git_commits_since_tag(git_tag: str) -> list[Change]: """ Get all commits since the last tag. Args: git_tag: Reference tag from which the changes to the current commit are fetched. Returns: List of all changes since git_tag. """ commits = ( subprocess.check_output( [ "git", "--no-pager", "log", f"{git_tag}..HEAD", '--pretty=format:"%H:::%s:::%aN"', ], stderr=subprocess.STDOUT, ) .decode("UTF-8") .strip() ) lines = commits.splitlines() authors = get_author_mapping(len(lines)) return [parse_commit_line(line, authors) for line in lines if line != ""] def parse_commit_line(line: str, authors: dict[str, str]) -> Change: """ Parse the first line of a git commit message. Args: line: The first line of a git commit message. Returns: The parsed Change object Raises: ValueError: The commit line is not well-structured """ parts = line.strip().strip('"\\').split(":::") if len(parts) != 3: raise ValueError(f"Invalid commit line: '{line}'") commit_hash, rest, author = parts if ":" in rest: prefix, message = rest.split(": ", 1) else: prefix = "" message = rest # Standardize message = message.strip() commit_hash = commit_hash.strip() author_login = authors[commit_hash] prefix = prefix.strip() if prefix == "DOCS": prefix = "DOC" return Change( commit_hash=commit_hash, prefix=prefix, message=message, author=author, author_login=author_login, ) if __name__ == "__main__": main(CHANGELOG_FILE_PATH) pypdf-6.1.2/pypdf/000077500000000000000000000000001507516550200137725ustar00rootroot00000000000000pypdf-6.1.2/pypdf/__init__.py000066400000000000000000000024031507516550200161020ustar00rootroot00000000000000""" pypdf is a free and open-source pure-python PDF library capable of splitting, merging, cropping, and transforming the pages of PDF files. It can also add custom data, viewing options, and passwords to PDF files. pypdf can retrieve text and metadata from PDFs as well. You can read the full docs at https://pypdf.readthedocs.io/. """ from ._crypt_providers import crypt_provider from ._doc_common import DocumentInformation from ._encryption import PasswordType from ._page import PageObject, Transformation from ._reader import PdfReader from ._text_extraction import mult from ._version import __version__ from ._writer import ObjectDeletionFlag, PdfWriter from .constants import ImageType from .pagerange import PageRange, parse_filename_page_ranges from .papersizes import PaperSize try: import PIL pil_version = PIL.__version__ except ImportError: pil_version = "none" _debug_versions = ( f"pypdf=={__version__}, {crypt_provider=}, PIL={pil_version}" ) __all__ = [ "DocumentInformation", "ImageType", "ObjectDeletionFlag", "PageObject", "PageRange", "PaperSize", "PasswordType", "PdfReader", "PdfWriter", "Transformation", "__version__", "_debug_versions", "mult", "parse_filename_page_ranges", ] pypdf-6.1.2/pypdf/_cmap.py000066400000000000000000000447471507516550200154430ustar00rootroot00000000000000import binascii from binascii import Error as BinasciiError from binascii import unhexlify from math import ceil from typing import Any, Union, cast from ._codecs import adobe_glyphs, charset_encoding from ._utils import logger_error, logger_warning from .generic import ( ArrayObject, DecodedStreamObject, DictionaryObject, NullObject, StreamObject, is_null_or_none, ) # code freely inspired from @twiggy ; see #711 def build_char_map( font_name: str, space_width: float, obj: DictionaryObject ) -> tuple[str, float, Union[str, dict[int, str]], dict[Any, Any], DictionaryObject]: """ Determine information about a font. Args: font_name: font name as a string space_width: default space width if no data is found. obj: XObject or Page where you can find a /Resource dictionary Returns: Font sub-type, space_width criteria (50% of width), encoding, map character-map, font-dictionary. The font-dictionary itself is suitable for the curious. """ ft: DictionaryObject = obj["/Resources"]["/Font"][font_name] # type: ignore font_subtype, font_halfspace, font_encoding, font_map = build_char_map_from_dict( space_width, ft ) return font_subtype, font_halfspace, font_encoding, font_map, ft def build_char_map_from_dict( space_width: float, ft: DictionaryObject ) -> tuple[str, float, Union[str, dict[int, str]], dict[Any, Any]]: """ Determine information about a font. Args: space_width: default space with if no data found (normally half the width of a character). ft: Font Dictionary Returns: Font sub-type, space_width criteria(50% of width), encoding, map character-map. The font-dictionary itself is suitable for the curious. """ font_type = cast(str, ft["/Subtype"].get_object()) encoding, map_dict = get_encoding(ft) space_key_char = get_actual_str_key(" ", encoding, map_dict) font_width_map = build_font_width_map(ft, space_width * 2.0) half_space_width = compute_space_width(font_width_map, space_key_char) / 2.0 return ( font_type, half_space_width, encoding, # https://github.com/python/mypy/issues/4374 map_dict ) # used when missing data, e.g. font def missing unknown_char_map: tuple[str, float, Union[str, dict[int, str]], dict[Any, Any]] = ( "Unknown", 9999, dict.fromkeys(range(256), "ďż˝"), {}, ) _predefined_cmap: dict[str, str] = { "/Identity-H": "utf-16-be", "/Identity-V": "utf-16-be", "/GB-EUC-H": "gbk", "/GB-EUC-V": "gbk", "/GBpc-EUC-H": "gb2312", "/GBpc-EUC-V": "gb2312", "/GBK-EUC-H": "gbk", "/GBK-EUC-V": "gbk", "/GBK2K-H": "gb18030", "/GBK2K-V": "gb18030", "/ETen-B5-H": "cp950", "/ETen-B5-V": "cp950", "/ETenms-B5-H": "cp950", "/ETenms-B5-V": "cp950", "/UniCNS-UTF16-H": "utf-16-be", "/UniCNS-UTF16-V": "utf-16-be", "/UniGB-UTF16-H": "gb18030", "/UniGB-UTF16-V": "gb18030", # UCS2 in code } # manually extracted from http://mirrors.ctan.org/fonts/adobe/afm/Adobe-Core35_AFMs-229.tar.gz _default_fonts_space_width: dict[str, int] = { "/Courier": 600, "/Courier-Bold": 600, "/Courier-BoldOblique": 600, "/Courier-Oblique": 600, "/Helvetica": 278, "/Helvetica-Bold": 278, "/Helvetica-BoldOblique": 278, "/Helvetica-Oblique": 278, "/Helvetica-Narrow": 228, "/Helvetica-NarrowBold": 228, "/Helvetica-NarrowBoldOblique": 228, "/Helvetica-NarrowOblique": 228, "/Times-Roman": 250, "/Times-Bold": 250, "/Times-BoldItalic": 250, "/Times-Italic": 250, "/Symbol": 250, "/ZapfDingbats": 278, } def get_encoding( ft: DictionaryObject ) -> tuple[Union[str, dict[int, str]], dict[Any, Any]]: encoding = _parse_encoding(ft) map_dict, int_entry = _parse_to_unicode(ft) # Apply rule from PDF ref 1.7 §5.9.1, 1st bullet: # if cmap not empty encoding should be discarded # (here transformed into identity for those characters) # If encoding is a string, it is expected to be an identity translation. if isinstance(encoding, dict): for x in int_entry: if x <= 255: encoding[x] = chr(x) return encoding, map_dict def _parse_encoding( ft: DictionaryObject ) -> Union[str, dict[int, str]]: encoding: Union[str, list[str], dict[int, str]] = [] if "/Encoding" not in ft: if "/BaseFont" in ft and cast(str, ft["/BaseFont"]) in charset_encoding: encoding = dict( zip(range(256), charset_encoding[cast(str, ft["/BaseFont"])]) ) else: encoding = "charmap" return encoding enc: Union[str, DictionaryObject, NullObject] = cast( Union[str, DictionaryObject, NullObject], ft["/Encoding"].get_object() ) if isinstance(enc, str): try: # already done : enc = NameObject.unnumber(enc.encode()).decode() # for #xx decoding if enc in charset_encoding: encoding = charset_encoding[enc].copy() elif enc in _predefined_cmap: encoding = _predefined_cmap[enc] elif "-UCS2-" in enc: encoding = "utf-16-be" else: raise Exception("not found") except Exception: logger_error(f"Advanced encoding {enc} not implemented yet", __name__) encoding = enc elif isinstance(enc, DictionaryObject) and "/BaseEncoding" in enc: try: encoding = charset_encoding[cast(str, enc["/BaseEncoding"])].copy() except Exception: logger_error( f"Advanced encoding {encoding} not implemented yet", __name__, ) encoding = charset_encoding["/StandardEncoding"].copy() else: encoding = charset_encoding["/StandardEncoding"].copy() if isinstance(enc, DictionaryObject) and "/Differences" in enc: x: int = 0 o: Union[int, str] for o in cast(DictionaryObject, enc["/Differences"]): if isinstance(o, int): x = o else: # isinstance(o, str): try: if x < len(encoding): encoding[x] = adobe_glyphs[o] # type: ignore except Exception: encoding[x] = o # type: ignore x += 1 if isinstance(encoding, list): encoding = dict(zip(range(256), encoding)) return encoding def _parse_to_unicode( ft: DictionaryObject ) -> tuple[dict[Any, Any], list[int]]: # will store all translation code # and map_dict[-1] we will have the number of bytes to convert map_dict: dict[Any, Any] = {} # will provide the list of cmap keys as int to correct encoding int_entry: list[int] = [] if "/ToUnicode" not in ft: if ft.get("/Subtype", "") == "/Type1": return _type1_alternative(ft, map_dict, int_entry) return {}, [] process_rg: bool = False process_char: bool = False multiline_rg: Union[ None, tuple[int, int] ] = None # tuple = (current_char, remaining size) ; cf #1285 for example of file cm = prepare_cm(ft) for line in cm.split(b"\n"): process_rg, process_char, multiline_rg = process_cm_line( line.strip(b" \t"), process_rg, process_char, multiline_rg, map_dict, int_entry, ) return map_dict, int_entry def get_actual_str_key( value_char: str, encoding: Union[str, dict[int, str]], map_dict: dict[Any, Any] ) -> str: key_dict = {} if isinstance(encoding, dict): key_dict = {value: chr(key) for key, value in encoding.items() if value == value_char} else: key_dict = {value: key for key, value in map_dict.items() if value == value_char} return key_dict.get(value_char, value_char) def prepare_cm(ft: DictionaryObject) -> bytes: tu = ft["/ToUnicode"] cm: bytes if isinstance(tu, StreamObject): cm = cast(DecodedStreamObject, ft["/ToUnicode"]).get_data() else: # if (tu is None) or cast(str, tu).startswith("/Identity"): # the full range 0000-FFFF will be processed cm = b"beginbfrange\n<0000> <0001> <0000>\nendbfrange" if isinstance(cm, str): cm = cm.encode() # we need to prepare cm before due to missing return line in pdf printed # to pdf from word cm = ( cm.strip() .replace(b"beginbfchar", b"\nbeginbfchar\n") .replace(b"endbfchar", b"\nendbfchar\n") .replace(b"beginbfrange", b"\nbeginbfrange\n") .replace(b"endbfrange", b"\nendbfrange\n") .replace(b"<<", b"\n{\n") # text between << and >> not used but .replace(b">>", b"\n}\n") # some solution to find it back ) ll = cm.split(b"<") for i in range(len(ll)): j = ll[i].find(b">") if j >= 0: if j == 0: # string is empty: stash a placeholder here (see below) # see https://github.com/py-pdf/pypdf/issues/1111 content = b"." else: content = ll[i][:j].replace(b" ", b"") ll[i] = content + b" " + ll[i][j + 1 :] cm = ( (b" ".join(ll)) .replace(b"[", b" [ ") .replace(b"]", b" ]\n ") .replace(b"\r", b"\n") ) return cm def process_cm_line( line: bytes, process_rg: bool, process_char: bool, multiline_rg: Union[None, tuple[int, int]], map_dict: dict[Any, Any], int_entry: list[int], ) -> tuple[bool, bool, Union[None, tuple[int, int]]]: if line == b"" or line[0] == 37: # 37 = % return process_rg, process_char, multiline_rg line = line.replace(b"\t", b" ") if b"beginbfrange" in line: process_rg = True elif b"endbfrange" in line: process_rg = False elif b"beginbfchar" in line: process_char = True elif b"endbfchar" in line: process_char = False elif process_rg: try: multiline_rg = parse_bfrange(line, map_dict, int_entry, multiline_rg) except binascii.Error as error: logger_warning(f"Skipping broken line {line!r}: {error}", __name__) elif process_char: parse_bfchar(line, map_dict, int_entry) return process_rg, process_char, multiline_rg def parse_bfrange( line: bytes, map_dict: dict[Any, Any], int_entry: list[int], multiline_rg: Union[None, tuple[int, int]], ) -> Union[None, tuple[int, int]]: lst = [x for x in line.split(b" ") if x] closure_found = False if multiline_rg is not None: fmt = b"%%0%dX" % (map_dict[-1] * 2) a = multiline_rg[0] # a, b not in the current line b = multiline_rg[1] for sq in lst: if sq == b"]": closure_found = True break map_dict[ unhexlify(fmt % a).decode( "charmap" if map_dict[-1] == 1 else "utf-16-be", "surrogatepass", ) ] = unhexlify(sq).decode("utf-16-be", "surrogatepass") int_entry.append(a) a += 1 else: a = int(lst[0], 16) b = int(lst[1], 16) nbi = max(len(lst[0]), len(lst[1])) map_dict[-1] = ceil(nbi / 2) fmt = b"%%0%dX" % (map_dict[-1] * 2) if lst[2] == b"[": for sq in lst[3:]: if sq == b"]": closure_found = True break map_dict[ unhexlify(fmt % a).decode( "charmap" if map_dict[-1] == 1 else "utf-16-be", "surrogatepass", ) ] = unhexlify(sq).decode("utf-16-be", "surrogatepass") int_entry.append(a) a += 1 else: # case without list c = int(lst[2], 16) fmt2 = b"%%0%dX" % max(4, len(lst[2])) closure_found = True while a <= b: map_dict[ unhexlify(fmt % a).decode( "charmap" if map_dict[-1] == 1 else "utf-16-be", "surrogatepass", ) ] = unhexlify(fmt2 % c).decode("utf-16-be", "surrogatepass") int_entry.append(a) a += 1 c += 1 return None if closure_found else (a, b) def parse_bfchar(line: bytes, map_dict: dict[Any, Any], int_entry: list[int]) -> None: lst = [x for x in line.split(b" ") if x] map_dict[-1] = len(lst[0]) // 2 while len(lst) > 1: map_to = "" # placeholder (see above) means empty string if lst[1] != b".": try: map_to = unhexlify(lst[1]).decode( "charmap" if len(lst[1]) < 4 else "utf-16-be", "surrogatepass" ) # join is here as some cases where the code was split except BinasciiError as exception: logger_warning(f"Got invalid hex string: {exception!s} ({lst[1]!r})", __name__) map_dict[ unhexlify(lst[0]).decode( "charmap" if map_dict[-1] == 1 else "utf-16-be", "surrogatepass" ) ] = map_to int_entry.append(int(lst[0], 16)) lst = lst[2:] def build_font_width_map( ft: DictionaryObject, default_font_width: float ) -> dict[Any, float]: font_width_map: dict[Any, float] = {} st: int = 0 en: int = 0 try: default_font_width = _default_fonts_space_width[cast(str, ft["/BaseFont"].get_object())] * 2.0 except KeyError: pass if "/DescendantFonts" in ft: # ft["/Subtype"].startswith("/CIDFontType"): # §9.7.4.3 of the 1.7 reference ("Glyph Metrics in CIDFonts") # Widths for a CIDFont are defined using the DW and W entries. # DW2 and W2 are for vertical use. Vertical type is not implemented. ft1 = ft["/DescendantFonts"][0].get_object() # type: ignore if "/DW" in ft1: font_width_map["default"] = cast(float, ft1["/DW"].get_object()) else: font_width_map["default"] = default_font_width if "/W" in ft1: w = ft1["/W"].get_object() else: w = [] while len(w) > 0: st = w[0] if isinstance(w[0], int) else w[0].get_object() second = w[1].get_object() if isinstance(second, int): # C_first C_last same_W en = second width = w[2].get_object() if not isinstance(width, (int, float)): logger_warning(f"Expected numeric value for width, got {width}. Ignoring it.", __name__) w = w[3:] continue for c_code in range(st, en + 1): font_width_map[chr(c_code)] = width w = w[3:] elif isinstance(second, list): # Starting_C [W1 W2 ... Wn] c_code = st for ww in second: width = ww.get_object() font_width_map[chr(c_code)] = width c_code += 1 w = w[2:] else: logger_warning( "unknown widths : \n" + (ft1["/W"]).__repr__(), __name__, ) break elif "/Widths" in ft: w = cast(ArrayObject, ft["/Widths"].get_object()) if "/FontDescriptor" in ft and "/MissingWidth" in cast( DictionaryObject, ft["/FontDescriptor"] ): font_width_map["default"] = ft["/FontDescriptor"]["/MissingWidth"].get_object() # type: ignore else: # will consider width of char as avg(width) m = 0 cpt = 0 for xx in w: xx = xx.get_object() if xx > 0: m += xx cpt += 1 font_width_map["default"] = m / max(1, cpt) st = cast(int, ft["/FirstChar"]) en = cast(int, ft["/LastChar"]) for c_code in range(st, en + 1): try: width = w[c_code - st].get_object() font_width_map[chr(c_code)] = width except (IndexError, KeyError): # The PDF structure is invalid. The array is too small # for the specified font width. pass if is_null_or_none(font_width_map.get("default")): font_width_map["default"] = default_font_width if default_font_width else 0.0 return font_width_map def compute_space_width( font_width_map: dict[Any, float], space_char: str ) -> float: try: sp_width = font_width_map[space_char] if sp_width == 0: raise ValueError("Zero width") except (KeyError, ValueError): sp_width = ( font_width_map["default"] / 2.0 ) # if using default we consider space will be only half size return sp_width def compute_font_width( font_width_map: dict[Any, float], char: str ) -> float: char_width: float = 0.0 try: char_width = font_width_map[char] except KeyError: char_width = ( font_width_map["default"] ) return char_width def _type1_alternative( ft: DictionaryObject, map_dict: dict[Any, Any], int_entry: list[int], ) -> tuple[dict[Any, Any], list[int]]: if "/FontDescriptor" not in ft: return map_dict, int_entry ft_desc = cast(DictionaryObject, ft["/FontDescriptor"]).get("/FontFile") if is_null_or_none(ft_desc): return map_dict, int_entry assert ft_desc is not None, "mypy" txt = ft_desc.get_object().get_data() txt = txt.split(b"eexec\n")[0] # only clear part txt = txt.split(b"/Encoding")[1] # to get the encoding part lines = txt.replace(b"\r", b"\n").split(b"\n") for li in lines: if li.startswith(b"dup"): words = [_w for _w in li.split(b" ") if _w != b""] if len(words) > 3 and words[3] != b"put": continue try: i = int(words[1]) except ValueError: # pragma: no cover continue try: v = adobe_glyphs[words[2].decode()] except KeyError: if words[2].startswith(b"/uni"): try: v = chr(int(words[2][4:], 16)) except ValueError: # pragma: no cover continue else: continue map_dict[chr(i)] = v int_entry.append(i) return map_dict, int_entry pypdf-6.1.2/pypdf/_codecs/000077500000000000000000000000001507516550200153715ustar00rootroot00000000000000pypdf-6.1.2/pypdf/_codecs/__init__.py000066400000000000000000000031551507516550200175060ustar00rootroot00000000000000from .adobe_glyphs import adobe_glyphs from .pdfdoc import _pdfdoc_encoding from .std import _std_encoding from .symbol import _symbol_encoding from .zapfding import _zapfding_encoding def fill_from_encoding(enc: str) -> list[str]: lst: list[str] = [] for x in range(256): try: lst += (bytes((x,)).decode(enc),) except Exception: lst += (chr(x),) return lst def rev_encoding(enc: list[str]) -> dict[str, int]: rev: dict[str, int] = {} for i in range(256): char = enc[i] if char == "\u0000": continue assert char not in rev, f"{char} at {i} already at {rev[char]}" rev[char] = i return rev _win_encoding = fill_from_encoding("cp1252") _mac_encoding = fill_from_encoding("mac_roman") _win_encoding_rev: dict[str, int] = rev_encoding(_win_encoding) _mac_encoding_rev: dict[str, int] = rev_encoding(_mac_encoding) _symbol_encoding_rev: dict[str, int] = rev_encoding(_symbol_encoding) _zapfding_encoding_rev: dict[str, int] = rev_encoding(_zapfding_encoding) _pdfdoc_encoding_rev: dict[str, int] = rev_encoding(_pdfdoc_encoding) charset_encoding: dict[str, list[str]] = { "/StandardEncoding": _std_encoding, "/WinAnsiEncoding": _win_encoding, "/MacRomanEncoding": _mac_encoding, "/PDFDocEncoding": _pdfdoc_encoding, "/Symbol": _symbol_encoding, "/ZapfDingbats": _zapfding_encoding, } __all__ = [ "_mac_encoding", "_pdfdoc_encoding", "_pdfdoc_encoding_rev", "_std_encoding", "_symbol_encoding", "_win_encoding", "_zapfding_encoding", "adobe_glyphs", "charset_encoding", ] pypdf-6.1.2/pypdf/_codecs/_codecs.py000066400000000000000000000235521507516550200173510ustar00rootroot00000000000000""" This module is for codecs only. While the codec implementation can contain details of the PDF specification, the module should not do any PDF parsing. """ import io from abc import ABC, abstractmethod from pypdf._utils import logger_warning class Codec(ABC): """Abstract base class for all codecs.""" @abstractmethod def encode(self, data: bytes) -> bytes: """ Encode the input data. Args: data: Data to encode. Returns: Encoded data. """ @abstractmethod def decode(self, data: bytes) -> bytes: """ Decode the input data. Args: data: Data to decode. Returns: Decoded data. """ class LzwCodec(Codec): """Lempel-Ziv-Welch (LZW) adaptive compression codec.""" CLEAR_TABLE_MARKER = 256 # Special code to indicate table reset EOD_MARKER = 257 # End-of-data marker INITIAL_BITS_PER_CODE = 9 # Initial code bit width MAX_BITS_PER_CODE = 12 # Maximum code bit width def _initialize_encoding_table(self) -> None: """Initialize the encoding table and state to initial conditions.""" self.encoding_table: dict[bytes, int] = {bytes([i]): i for i in range(256)} self.next_code = self.EOD_MARKER + 1 self.bits_per_code = self.INITIAL_BITS_PER_CODE self.max_code_value = (1 << self.bits_per_code) - 1 def _increase_next_code(self) -> None: """Update bits_per_code and max_code_value if necessary.""" self.next_code += 1 if ( self.next_code > self.max_code_value and self.bits_per_code < self.MAX_BITS_PER_CODE ): self.bits_per_code += 1 self.max_code_value = (1 << self.bits_per_code) - 1 def encode(self, data: bytes) -> bytes: """ Encode data using the LZW compression algorithm. Taken from PDF 1.7 specs, "7.4.4.2 Details of LZW Encoding". """ result_codes: list[int] = [] # The encoder shall begin by issuing a clear-table code result_codes.append(self.CLEAR_TABLE_MARKER) self._initialize_encoding_table() current_sequence = b"" for byte in data: next_sequence = current_sequence + bytes([byte]) if next_sequence in self.encoding_table: # Extend current sequence if already in the table current_sequence = next_sequence else: # Output code for the current sequence result_codes.append(self.encoding_table[current_sequence]) # Add the new sequence to the table if there's room if self.next_code <= (1 << self.MAX_BITS_PER_CODE) - 1: self.encoding_table[next_sequence] = self.next_code self._increase_next_code() else: # If the table is full, emit a clear-table command result_codes.append(self.CLEAR_TABLE_MARKER) self._initialize_encoding_table() # Start new sequence current_sequence = bytes([byte]) # Ensure everything actually is encoded if current_sequence: result_codes.append(self.encoding_table[current_sequence]) result_codes.append(self.EOD_MARKER) return self._pack_codes_into_bytes(result_codes) def _pack_codes_into_bytes(self, codes: list[int]) -> bytes: """ Convert the list of result codes into a continuous byte stream, with codes packed as per the code bit-width. The bit-width starts at 9 bits and expands as needed. """ self._initialize_encoding_table() buffer = 0 bits_in_buffer = 0 output = bytearray() for code in codes: buffer = (buffer << self.bits_per_code) | code bits_in_buffer += self.bits_per_code # Codes shall be packed into a continuous bit stream, high-order bit # first. This stream shall then be divided into bytes, high-order bit # first. while bits_in_buffer >= 8: bits_in_buffer -= 8 output.append((buffer >> bits_in_buffer) & 0xFF) if code == self.CLEAR_TABLE_MARKER: self._initialize_encoding_table() elif code == self.EOD_MARKER: continue else: self._increase_next_code() # Flush any remaining bits in the buffer if bits_in_buffer > 0: output.append((buffer << (8 - bits_in_buffer)) & 0xFF) return bytes(output) def _initialize_decoding_table(self) -> None: self.max_code_value = (1 << self.MAX_BITS_PER_CODE) - 1 self.decoding_table = [bytes([i]) for i in range(self.CLEAR_TABLE_MARKER)] + [ b"" ] * (self.max_code_value - self.CLEAR_TABLE_MARKER + 1) self._table_index = self.EOD_MARKER + 1 self._bits_to_get = 9 def _next_code_decode(self, data: bytes) -> int: self._next_data: int try: while self._next_bits < self._bits_to_get: self._next_data = (self._next_data << 8) | ( data[self._byte_pointer] ) self._byte_pointer += 1 self._next_bits += 8 code = ( self._next_data >> (self._next_bits - self._bits_to_get) ) & self._and_table[self._bits_to_get - 9] self._next_bits -= self._bits_to_get # Reduce data to get rid of the overhead, # which increases performance on large streams significantly. self._next_data = self._next_data & 0xFFFFF return code except IndexError: return self.EOD_MARKER # The following method has been converted to Python from PDFsharp: # https://github.com/empira/PDFsharp/blob/5fbf6ed14740bc4e16786816882d32e43af3ff5d/src/foundation/src/PDFsharp/src/PdfSharp/Pdf.Filters/LzwDecode.cs # # Original license: # # ------------------------------------------------------------------------- # Copyright (c) 2001-2024 empira Software GmbH, Troisdorf (Cologne Area), # Germany # # http://docs.pdfsharp.net # # MIT License # # Permission is hereby granted, free of charge, to any person obtaining a # copy of this software and associated documentation files (the "Software"), # to deal in the Software without restriction, including without limitation # the rights to use, copy, modify, merge, publish, distribute, sublicense, # and/or sell copies of the Software, and to permit persons to whom the # Software is furnished to do so, subject to the following conditions: # # The above copyright notice and this permission notice shall be included # in all copies or substantial portions of the Software. # # THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR # IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, # FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL # THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER # LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING # FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER # DEALINGS IN THE SOFTWARE. # -------------------------------------------------------------------------- def decode(self, data: bytes) -> bytes: """ The following code was converted to Python from the following code: https://github.com/empira/PDFsharp/blob/master/src/foundation/src/PDFsharp/src/PdfSharp/Pdf.Filters/LzwDecode.cs """ self._and_table = [511, 1023, 2047, 4095] self._table_index = 0 self._bits_to_get = 9 self._byte_pointer = 0 self._next_data = 0 self._next_bits = 0 output_stream = io.BytesIO() self._initialize_decoding_table() self._byte_pointer = 0 self._next_data = 0 self._next_bits = 0 old_code = self.CLEAR_TABLE_MARKER while True: code = self._next_code_decode(data) if code == self.EOD_MARKER: break if code == self.CLEAR_TABLE_MARKER: self._initialize_decoding_table() code = self._next_code_decode(data) if code == self.EOD_MARKER: break output_stream.write(self.decoding_table[code]) old_code = code elif code < self._table_index: string = self.decoding_table[code] output_stream.write(string) if old_code != self.CLEAR_TABLE_MARKER: self._add_entry_decode(self.decoding_table[old_code], string[0]) old_code = code else: # The code is not in the table and not one of the special codes string = ( self.decoding_table[old_code] + self.decoding_table[old_code][:1] ) output_stream.write(string) self._add_entry_decode(self.decoding_table[old_code], string[0]) old_code = code return output_stream.getvalue() def _add_entry_decode(self, old_string: bytes, new_char: int) -> None: new_string = old_string + bytes([new_char]) if self._table_index > self.max_code_value: logger_warning("Ignoring too large LZW table index.", __name__) return self.decoding_table[self._table_index] = new_string self._table_index += 1 # Update the number of bits to get based on the table index if self._table_index == 511: self._bits_to_get = 10 elif self._table_index == 1023: self._bits_to_get = 11 elif self._table_index == 2047: self._bits_to_get = 12 pypdf-6.1.2/pypdf/_codecs/adobe_glyphs.py000066400000000000000000015513551507516550200204220ustar00rootroot00000000000000# https://raw.githubusercontent.com/adobe-type-tools/agl-aglfn/master/glyphlist.txt # converted manually to python # Extended with data from GlyphNameFormatter: # https://github.com/LettError/glyphNameFormatter # ----------------------------------------------------------- # Copyright 2002-2019 Adobe (http://www.adobe.com/). # # Redistribution and use in source and binary forms, with or # without modification, are permitted provided that the # following conditions are met: # # Redistributions of source code must retain the above # copyright notice, this list of conditions and the following # disclaimer. # # Redistributions in binary form must reproduce the above # copyright notice, this list of conditions and the following # disclaimer in the documentation and/or other materials # provided with the distribution. # # Neither the name of Adobe nor the names of its contributors # may be used to endorse or promote products derived from this # software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND # CONTRIBUTORS "AS IS" AND ANY EXPRESS OR IMPLIED WARRANTIES, # INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF # MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE # DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT HOLDER OR # CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, # SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT # NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; # LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) # HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR # OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS # SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. # ----------------------------------------------------------- # Name: Adobe Glyph List # Table version: 2.0 # Date: September 20, 2002 # URL: https://github.com/adobe-type-tools/agl-aglfn # # Format: two semicolon-delimited fields: # (1) glyph name--upper/lowercase letters and digits # (2) Unicode scalar value--four uppercase hexadecimal digits # adobe_glyphs = { "/A": "\u0041", "/AA": "\uA732", "/AE": "\u00C6", "/AEacute": "\u01FC", "/AEmacron": "\u01E2", "/AEsmall": "\uF7E6", "/AO": "\uA734", "/AU": "\uA736", "/AV": "\uA738", "/AVhorizontalbar": "\uA73A", "/AY": "\uA73C", "/Aacute": "\u00C1", "/Aacutesmall": "\uF7E1", "/Abreve": "\u0102", "/Abreveacute": "\u1EAE", "/Abrevecyr": "\u04D0", "/Abrevecyrillic": "\u04D0", "/Abrevedotbelow": "\u1EB6", "/Abrevegrave": "\u1EB0", "/Abrevehoi": "\u1EB2", "/Abrevehookabove": "\u1EB2", "/Abrevetilde": "\u1EB4", "/Acaron": "\u01CD", "/Acircle": "\u24B6", "/Acircleblack": "\u1F150", "/Acircumflex": "\u00C2", "/Acircumflexacute": "\u1EA4", "/Acircumflexdotbelow": "\u1EAC", "/Acircumflexgrave": "\u1EA6", "/Acircumflexhoi": "\u1EA8", "/Acircumflexhookabove": "\u1EA8", "/Acircumflexsmall": "\uF7E2", "/Acircumflextilde": "\u1EAA", "/Acute": "\uF6C9", "/Acutesmall": "\uF7B4", "/Acyr": "\u0410", "/Acyrillic": "\u0410", "/Adblgrave": "\u0200", "/Adieresis": "\u00C4", "/Adieresiscyr": "\u04D2", "/Adieresiscyrillic": "\u04D2", "/Adieresismacron": "\u01DE", "/Adieresissmall": "\uF7E4", "/Adot": "\u0226", "/Adotbelow": "\u1EA0", "/Adotmacron": "\u01E0", "/Agrave": "\u00C0", "/Agravedbl": "\u0200", "/Agravesmall": "\uF7E0", "/Ahoi": "\u1EA2", "/Ahookabove": "\u1EA2", "/Aiecyr": "\u04D4", "/Aiecyrillic": "\u04D4", "/Ainvertedbreve": "\u0202", "/Akbar": "\uFDF3", "/Alayhe": "\uFDF7", "/Allah": "\uFDF2", "/Alpha": "\u0391", "/Alphaacute": "\u1FBB", "/Alphaasper": "\u1F09", "/Alphaasperacute": "\u1F0D", "/Alphaasperacuteiotasub": "\u1F8D", "/Alphaaspergrave": "\u1F0B", "/Alphaaspergraveiotasub": "\u1F8B", "/Alphaasperiotasub": "\u1F89", "/Alphaaspertilde": "\u1F0F", "/Alphaaspertildeiotasub": "\u1F8F", "/Alphabreve": "\u1FB8", "/Alphagrave": "\u1FBA", "/Alphaiotasub": "\u1FBC", "/Alphalenis": "\u1F08", "/Alphalenisacute": "\u1F0C", "/Alphalenisacuteiotasub": "\u1F8C", "/Alphalenisgrave": "\u1F0A", "/Alphalenisgraveiotasub": "\u1F8A", "/Alphalenisiotasub": "\u1F88", "/Alphalenistilde": "\u1F0E", "/Alphalenistildeiotasub": "\u1F8E", "/Alphatonos": "\u0386", "/Alphawithmacron": "\u1FB9", "/Amacron": "\u0100", "/Amonospace": "\uFF21", "/Aogonek": "\u0104", "/Aparens": "\u1F110", "/Aring": "\u00C5", "/Aringacute": "\u01FA", "/Aringbelow": "\u1E00", "/Aringsmall": "\uF7E5", "/Asmall": "\uF761", "/Asquare": "\u1F130", "/Asquareblack": "\u1F170", "/Astroke": "\u023A", "/Atilde": "\u00C3", "/Atildesmall": "\uF7E3", "/Aturned": "\u2C6F", "/Ayahend": "\u06DD", "/Aybarmenian": "\u0531", "/B": "\u0042", "/Bcircle": "\u24B7", "/Bcircleblack": "\u1F151", "/Bdot": "\u1E02", "/Bdotaccent": "\u1E02", "/Bdotbelow": "\u1E04", "/Becyr": "\u0411", "/Becyrillic": "\u0411", "/Benarmenian": "\u0532", "/Beta": "\u0392", "/Bflourish": "\uA796", "/Bhook": "\u0181", "/BismillahArRahmanArRaheem": "\uFDFD", "/Blinebelow": "\u1E06", "/Bmonospace": "\uFF22", "/Bparens": "\u1F111", "/Brevesmall": "\uF6F4", "/Bscript": "\u212C", "/Bsmall": "\uF762", "/Bsquare": "\u1F131", "/Bsquareblack": "\u1F171", "/Bstroke": "\u0243", "/Btopbar": "\u0182", "/C": "\u0043", "/CDcircle": "\u1F12D", "/Caarmenian": "\u053E", "/Cacute": "\u0106", "/Caron": "\uF6CA", "/Caronsmall": "\uF6F5", "/Cbar": "\uA792", "/Ccaron": "\u010C", "/Ccedilla": "\u00C7", "/Ccedillaacute": "\u1E08", "/Ccedillasmall": "\uF7E7", "/Ccircle": "\u24B8", "/Ccircleblack": "\u1F152", "/Ccircumflex": "\u0108", "/Cdblstruck": "\u2102", "/Cdot": "\u010A", "/Cdotaccent": "\u010A", "/Cdotreversed": "\uA73E", "/Cedillasmall": "\uF7B8", "/Cfraktur": "\u212D", "/Chaarmenian": "\u0549", "/Cheabkhasiancyrillic": "\u04BC", "/Cheabkhcyr": "\u04BC", "/Cheabkhtailcyr": "\u04BE", "/Checyr": "\u0427", "/Checyrillic": "\u0427", "/Chedescenderabkhasiancyrillic": "\u04BE", "/Chedescendercyrillic": "\u04B6", "/Chedieresiscyr": "\u04F4", "/Chedieresiscyrillic": "\u04F4", "/Cheharmenian": "\u0543", "/Chekhakascyr": "\u04CB", "/Chekhakassiancyrillic": "\u04CB", "/Chetailcyr": "\u04B6", "/Chevertcyr": "\u04B8", "/Cheverticalstrokecyrillic": "\u04B8", "/Chi": "\u03A7", "/Chook": "\u0187", "/Circumflexsmall": "\uF6F6", "/Citaliccircle": "\u1F12B", "/Cmonospace": "\uFF23", "/Coarmenian": "\u0551", "/Con": "\uA76E", "/Cparens": "\u1F112", "/Csmall": "\uF763", "/Csquare": "\u1F132", "/Csquareblack": "\u1F172", "/Cstretched": "\u0297", "/Cstroke": "\u023B", "/Cuatrillo": "\uA72C", "/Cuatrillocomma": "\uA72E", "/D": "\u0044", "/DZ": "\u01F1", "/DZcaron": "\u01C4", "/Daarmenian": "\u0534", "/Dafrican": "\u0189", "/Dcaron": "\u010E", "/Dcedilla": "\u1E10", "/Dchecyr": "\u052C", "/Dcircle": "\u24B9", "/Dcircleblack": "\u1F153", "/Dcircumflexbelow": "\u1E12", "/Dcroat": "\u0110", "/Ddblstruckitalic": "\u2145", "/Ddot": "\u1E0A", "/Ddotaccent": "\u1E0A", "/Ddotbelow": "\u1E0C", "/Decyr": "\u0414", "/Decyrillic": "\u0414", "/Deicoptic": "\u03EE", "/Dekomicyr": "\u0500", "/Delta": "\u2206", "/Deltagreek": "\u0394", "/Dhook": "\u018A", "/Dieresis": "\uF6CB", "/DieresisAcute": "\uF6CC", "/DieresisGrave": "\uF6CD", "/Dieresissmall": "\uF7A8", "/Digamma": "\u03DC", "/Digammagreek": "\u03DC", "/Digammapamphylian": "\u0376", "/Dinsular": "\uA779", "/Djecyr": "\u0402", "/Djecyrillic": "\u0402", "/Djekomicyr": "\u0502", "/Dlinebelow": "\u1E0E", "/Dmonospace": "\uFF24", "/Dotaccentsmall": "\uF6F7", "/Dparens": "\u1F113", "/Dslash": "\u0110", "/Dsmall": "\uF764", "/Dsquare": "\u1F133", "/Dsquareblack": "\u1F173", "/Dtopbar": "\u018B", "/Dz": "\u01F2", "/Dzcaron": "\u01C5", "/Dzeabkhasiancyrillic": "\u04E0", "/Dzeabkhcyr": "\u04E0", "/Dzecyr": "\u0405", "/Dzecyrillic": "\u0405", "/Dzhecyr": "\u040F", "/Dzhecyrillic": "\u040F", "/Dzjekomicyr": "\u0506", "/Dzzhecyr": "\u052A", "/E": "\u0045", "/Eacute": "\u00C9", "/Eacutesmall": "\uF7E9", "/Ebreve": "\u0114", "/Ecaron": "\u011A", "/Ecedilla": "\u0228", "/Ecedillabreve": "\u1E1C", "/Echarmenian": "\u0535", "/Ecircle": "\u24BA", "/Ecircleblack": "\u1F154", "/Ecircumflex": "\u00CA", "/Ecircumflexacute": "\u1EBE", "/Ecircumflexbelow": "\u1E18", "/Ecircumflexdotbelow": "\u1EC6", "/Ecircumflexgrave": "\u1EC0", "/Ecircumflexhoi": "\u1EC2", "/Ecircumflexhookabove": "\u1EC2", "/Ecircumflexsmall": "\uF7EA", "/Ecircumflextilde": "\u1EC4", "/Ecyrillic": "\u0404", "/Edblgrave": "\u0204", "/Edieresis": "\u00CB", "/Edieresissmall": "\uF7EB", "/Edot": "\u0116", "/Edotaccent": "\u0116", "/Edotbelow": "\u1EB8", "/Efcyr": "\u0424", "/Efcyrillic": "\u0424", "/Egrave": "\u00C8", "/Egravedbl": "\u0204", "/Egravesmall": "\uF7E8", "/Egyptain": "\uA724", "/Egyptalef": "\uA722", "/Eharmenian": "\u0537", "/Ehoi": "\u1EBA", "/Ehookabove": "\u1EBA", "/Eightroman": "\u2167", "/Einvertedbreve": "\u0206", "/Eiotifiedcyr": "\u0464", "/Eiotifiedcyrillic": "\u0464", "/Elcyr": "\u041B", "/Elcyrillic": "\u041B", "/Elevenroman": "\u216A", "/Elhookcyr": "\u0512", "/Elmiddlehookcyr": "\u0520", "/Elsharptailcyr": "\u04C5", "/Eltailcyr": "\u052E", "/Emacron": "\u0112", "/Emacronacute": "\u1E16", "/Emacrongrave": "\u1E14", "/Emcyr": "\u041C", "/Emcyrillic": "\u041C", "/Emonospace": "\uFF25", "/Emsharptailcyr": "\u04CD", "/Encyr": "\u041D", "/Encyrillic": "\u041D", "/Endescendercyrillic": "\u04A2", "/Eng": "\u014A", "/Engecyr": "\u04A4", "/Enghecyrillic": "\u04A4", "/Enhookcyr": "\u04C7", "/Enhookcyrillic": "\u04C7", "/Enhookleftcyr": "\u0528", "/Enmiddlehookcyr": "\u0522", "/Ensharptailcyr": "\u04C9", "/Entailcyr": "\u04A2", "/Eogonek": "\u0118", "/Eopen": "\u0190", "/Eparens": "\u1F114", "/Epsilon": "\u0395", "/Epsilonacute": "\u1FC9", "/Epsilonasper": "\u1F19", "/Epsilonasperacute": "\u1F1D", "/Epsilonaspergrave": "\u1F1B", "/Epsilongrave": "\u1FC8", "/Epsilonlenis": "\u1F18", "/Epsilonlenisacute": "\u1F1C", "/Epsilonlenisgrave": "\u1F1A", "/Epsilontonos": "\u0388", "/Ercyr": "\u0420", "/Ercyrillic": "\u0420", "/Ereversed": "\u018E", "/Ereversedcyr": "\u042D", "/Ereversedcyrillic": "\u042D", "/Ereverseddieresiscyr": "\u04EC", "/Ereversedopen": "\uA7AB", "/Ertickcyr": "\u048E", "/Escript": "\u2130", "/Escyr": "\u0421", "/Escyrillic": "\u0421", "/Esdescendercyrillic": "\u04AA", "/Esh": "\u01A9", "/Esmall": "\uF765", "/Esmallturned": "\u2C7B", "/Esquare": "\u1F134", "/Esquareblack": "\u1F174", "/Estailcyr": "\u04AA", "/Estroke": "\u0246", "/Et": "\uA76A", "/Eta": "\u0397", "/Etaacute": "\u1FCB", "/Etaasper": "\u1F29", "/Etaasperacute": "\u1F2D", "/Etaasperacuteiotasub": "\u1F9D", "/Etaaspergrave": "\u1F2B", "/Etaaspergraveiotasub": "\u1F9B", "/Etaasperiotasub": "\u1F99", "/Etaaspertilde": "\u1F2F", "/Etaaspertildeiotasub": "\u1F9F", "/Etagrave": "\u1FCA", "/Etaiotasub": "\u1FCC", "/Etalenis": "\u1F28", "/Etalenisacute": "\u1F2C", "/Etalenisacuteiotasub": "\u1F9C", "/Etalenisgrave": "\u1F2A", "/Etalenisgraveiotasub": "\u1F9A", "/Etalenisiotasub": "\u1F98", "/Etalenistilde": "\u1F2E", "/Etalenistildeiotasub": "\u1F9E", "/Etarmenian": "\u0538", "/Etatonos": "\u0389", "/Eth": "\u00D0", "/Ethsmall": "\uF7F0", "/Etilde": "\u1EBC", "/Etildebelow": "\u1E1A", "/Eukrcyr": "\u0404", "/Euro": "\u20AC", "/Ezh": "\u01B7", "/Ezhcaron": "\u01EE", "/Ezhreversed": "\u01B8", "/F": "\u0046", "/Fcircle": "\u24BB", "/Fcircleblack": "\u1F155", "/Fdot": "\u1E1E", "/Fdotaccent": "\u1E1E", "/Feharmenian": "\u0556", "/Feicoptic": "\u03E4", "/Fhook": "\u0191", "/Finsular": "\uA77B", "/Fitacyr": "\u0472", "/Fitacyrillic": "\u0472", "/Fiveroman": "\u2164", "/Fmonospace": "\uFF26", "/Fourroman": "\u2163", "/Fparens": "\u1F115", "/Fscript": "\u2131", "/Fsmall": "\uF766", "/Fsquare": "\u1F135", "/Fsquareblack": "\u1F175", "/Fstroke": "\uA798", "/Fturned": "\u2132", "/G": "\u0047", "/GBsquare": "\u3387", "/Gacute": "\u01F4", "/Gamma": "\u0393", "/Gammaafrican": "\u0194", "/Gammadblstruck": "\u213E", "/Gangiacoptic": "\u03EA", "/Gbreve": "\u011E", "/Gcaron": "\u01E6", "/Gcedilla": "\u0122", "/Gcircle": "\u24BC", "/Gcircleblack": "\u1F156", "/Gcircumflex": "\u011C", "/Gcommaaccent": "\u0122", "/Gdot": "\u0120", "/Gdotaccent": "\u0120", "/Gecyr": "\u0413", "/Gecyrillic": "\u0413", "/Gehookcyr": "\u0494", "/Gehookstrokecyr": "\u04FA", "/Germandbls": "\u1E9E", "/Gestrokecyr": "\u0492", "/Getailcyr": "\u04F6", "/Geupcyr": "\u0490", "/Ghadarmenian": "\u0542", "/Ghemiddlehookcyrillic": "\u0494", "/Ghestrokecyrillic": "\u0492", "/Gheupturncyrillic": "\u0490", "/Ghook": "\u0193", "/Ghooksmall": "\u029B", "/Gimarmenian": "\u0533", "/Ginsular": "\uA77D", "/Ginsularturned": "\uA77E", "/Gjecyr": "\u0403", "/Gjecyrillic": "\u0403", "/Glottalstop": "\u0241", "/Gmacron": "\u1E20", "/Gmonospace": "\uFF27", "/Gobliquestroke": "\uA7A0", "/Gparens": "\u1F116", "/Grave": "\uF6CE", "/Gravesmall": "\uF760", "/Gsmall": "\uF767", "/Gsmallhook": "\u029B", "/Gsquare": "\u1F136", "/Gsquareblack": "\u1F176", "/Gstroke": "\u01E4", "/Gturnedsans": "\u2141", "/H": "\u0048", "/H18533": "\u25CF", "/H18543": "\u25AA", "/H18551": "\u25AB", "/H22073": "\u25A1", "/HPsquare": "\u33CB", "/HVsquare": "\u1F14A", "/Haabkhasiancyrillic": "\u04A8", "/Haabkhcyr": "\u04A8", "/Hacyr": "\u0425", "/Hadescendercyrillic": "\u04B2", "/Hahookcyr": "\u04FC", "/Hardcyr": "\u042A", "/Hardsigncyrillic": "\u042A", "/Hastrokecyr": "\u04FE", "/Hbar": "\u0126", "/Hbrevebelow": "\u1E2A", "/Hcaron": "\u021E", "/Hcedilla": "\u1E28", "/Hcircle": "\u24BD", "/Hcircleblack": "\u1F157", "/Hcircumflex": "\u0124", "/Hdblstruck": "\u210D", "/Hdescender": "\u2C67", "/Hdieresis": "\u1E26", "/Hdot": "\u1E22", "/Hdotaccent": "\u1E22", "/Hdotbelow": "\u1E24", "/Heng": "\uA726", "/Heta": "\u0370", "/Hfraktur": "\u210C", "/Hgfullwidth": "\u32CC", "/Hhalf": "\u2C75", "/Hhook": "\uA7AA", "/Hmonospace": "\uFF28", "/Hoarmenian": "\u0540", "/HonAA": "\u0611", "/HonRA": "\u0612", "/HonSAW": "\u0610", "/Horicoptic": "\u03E8", "/Hparens": "\u1F117", "/Hscript": "\u210B", "/Hsmall": "\uF768", "/Hsquare": "\u1F137", "/Hsquareblack": "\u1F177", "/Hstrokemod": "\uA7F8", "/Hturned": "\uA78D", "/Hungarumlaut": "\uF6CF", "/Hungarumlautsmall": "\uF6F8", "/Hwair": "\u01F6", "/Hzsquare": "\u3390", "/I": "\u0049", "/IAcyrillic": "\u042F", "/ICsquareblack": "\u1F18B", "/IJ": "\u0132", "/IUcyrillic": "\u042E", "/Iacute": "\u00CD", "/Iacutesmall": "\uF7ED", "/Ibreve": "\u012C", "/Icaron": "\u01CF", "/Icircle": "\u24BE", "/Icircleblack": "\u1F158", "/Icircumflex": "\u00CE", "/Icircumflexsmall": "\uF7EE", "/Icyr": "\u0418", "/Icyrillic": "\u0406", "/Idblgrave": "\u0208", "/Idieresis": "\u00CF", "/Idieresisacute": "\u1E2E", "/Idieresiscyr": "\u04E4", "/Idieresiscyrillic": "\u04E4", "/Idieresissmall": "\uF7EF", "/Idot": "\u0130", "/Idotaccent": "\u0130", "/Idotbelow": "\u1ECA", "/Iebrevecyr": "\u04D6", "/Iebrevecyrillic": "\u04D6", "/Iecyr": "\u0415", "/Iecyrillic": "\u0415", "/Iegravecyr": "\u0400", "/Ifraktur": "\u2111", "/Igrave": "\u00CC", "/Igravecyr": "\u040D", "/Igravedbl": "\u0208", "/Igravesmall": "\uF7EC", "/Ihoi": "\u1EC8", "/Ihookabove": "\u1EC8", "/Iicyrillic": "\u0418", "/Iinvertedbreve": "\u020A", "/Iishortcyrillic": "\u0419", "/Imacron": "\u012A", "/Imacroncyr": "\u04E2", "/Imacroncyrillic": "\u04E2", "/Imonospace": "\uFF29", "/Iniarmenian": "\u053B", "/Iocyr": "\u0401", "/Iocyrillic": "\u0401", "/Iogonek": "\u012E", "/Iota": "\u0399", "/Iotaacute": "\u1FDB", "/Iotaafrican": "\u0196", "/Iotaasper": "\u1F39", "/Iotaasperacute": "\u1F3D", "/Iotaaspergrave": "\u1F3B", "/Iotaaspertilde": "\u1F3F", "/Iotabreve": "\u1FD8", "/Iotadieresis": "\u03AA", "/Iotagrave": "\u1FDA", "/Iotalenis": "\u1F38", "/Iotalenisacute": "\u1F3C", "/Iotalenisgrave": "\u1F3A", "/Iotalenistilde": "\u1F3E", "/Iotatonos": "\u038A", "/Iotawithmacron": "\u1FD9", "/Iparens": "\u1F118", "/Is": "\uA76C", "/Iscript": "\u2110", "/Ishortcyr": "\u0419", "/Ishortsharptailcyr": "\u048A", "/Ismall": "\uF769", "/Isquare": "\u1F138", "/Isquareblack": "\u1F178", "/Istroke": "\u0197", "/Itilde": "\u0128", "/Itildebelow": "\u1E2C", "/Iukrcyr": "\u0406", "/Izhitsacyr": "\u0474", "/Izhitsacyrillic": "\u0474", "/Izhitsadblgravecyrillic": "\u0476", "/Izhitsagravedblcyr": "\u0476", "/J": "\u004A", "/Jaarmenian": "\u0541", "/Jallajalalouhou": "\uFDFB", "/Jcircle": "\u24BF", "/Jcircleblack": "\u1F159", "/Jcircumflex": "\u0134", "/Jcrossed-tail": "\uA7B2", "/Jecyr": "\u0408", "/Jecyrillic": "\u0408", "/Jheharmenian": "\u054B", "/Jmonospace": "\uFF2A", "/Jparens": "\u1F119", "/Jsmall": "\uF76A", "/Jsquare": "\u1F139", "/Jsquareblack": "\u1F179", "/Jstroke": "\u0248", "/K": "\u004B", "/KBsquare": "\u3385", "/KKsquare": "\u33CD", "/KORONIS": "\u1FBD", "/Kaaleutcyr": "\u051E", "/Kabashkcyr": "\u04A0", "/Kabashkircyrillic": "\u04A0", "/Kacute": "\u1E30", "/Kacyr": "\u041A", "/Kacyrillic": "\u041A", "/Kadescendercyrillic": "\u049A", "/Kahookcyr": "\u04C3", "/Kahookcyrillic": "\u04C3", "/Kaisymbol": "\u03CF", "/Kappa": "\u039A", "/Kastrokecyr": "\u049E", "/Kastrokecyrillic": "\u049E", "/Katailcyr": "\u049A", "/Kaverticalstrokecyr": "\u049C", "/Kaverticalstrokecyrillic": "\u049C", "/Kcaron": "\u01E8", "/Kcedilla": "\u0136", "/Kcircle": "\u24C0", "/Kcircleblack": "\u1F15A", "/Kcommaaccent": "\u0136", "/Kdescender": "\u2C69", "/Kdiagonalstroke": "\uA742", "/Kdotbelow": "\u1E32", "/Keharmenian": "\u0554", "/Kenarmenian": "\u053F", "/Khacyrillic": "\u0425", "/Kheicoptic": "\u03E6", "/Khook": "\u0198", "/Kjecyr": "\u040C", "/Kjecyrillic": "\u040C", "/Klinebelow": "\u1E34", "/Kmonospace": "\uFF2B", "/Kobliquestroke": "\uA7A2", "/Koppa": "\u03DE", "/Koppaarchaic": "\u03D8", "/Koppacyr": "\u0480", "/Koppacyrillic": "\u0480", "/Koppagreek": "\u03DE", "/Kparens": "\u1F11A", "/Ksicyr": "\u046E", "/Ksicyrillic": "\u046E", "/Ksmall": "\uF76B", "/Ksquare": "\u1F13A", "/Ksquareblack": "\u1F17A", "/Kstroke": "\uA740", "/Kstrokediagonalstroke": "\uA744", "/Kturned": "\uA7B0", "/L": "\u004C", "/LJ": "\u01C7", "/LL": "\uF6BF", "/LLwelsh": "\u1EFA", "/LTDfullwidth": "\u32CF", "/Lacute": "\u0139", "/Lambda": "\u039B", "/Lbar": "\u023D", "/Lbelt": "\uA7AD", "/Lbroken": "\uA746", "/Lcaron": "\u013D", "/Lcedilla": "\u013B", "/Lcircle": "\u24C1", "/Lcircleblack": "\u1F15B", "/Lcircumflexbelow": "\u1E3C", "/Lcommaaccent": "\u013B", "/Ldblbar": "\u2C60", "/Ldot": "\u013F", "/Ldotaccent": "\u013F", "/Ldotbelow": "\u1E36", "/Ldotbelowmacron": "\u1E38", "/Lhacyr": "\u0514", "/Liwnarmenian": "\u053C", "/Lj": "\u01C8", "/Ljecyr": "\u0409", "/Ljecyrillic": "\u0409", "/Ljekomicyr": "\u0508", "/Llinebelow": "\u1E3A", "/Lmacrondot": "\u1E38", "/Lmiddletilde": "\u2C62", "/Lmonospace": "\uFF2C", "/Lparens": "\u1F11B", "/Lreversedsans": "\u2143", "/Lscript": "\u2112", "/Lslash": "\u0141", "/Lslashsmall": "\uF6F9", "/Lsmall": "\uF76C", "/Lsquare": "\u1F13B", "/Lsquareblack": "\u1F17B", "/Lstroke": "\uA748", "/Lturned": "\uA780", "/Lturnedsans": "\u2142", "/M": "\u004D", "/MBsquare": "\u3386", "/MVsquare": "\u1F14B", "/Macron": "\uF6D0", "/Macronsmall": "\uF7AF", "/Macute": "\u1E3E", "/Mcircle": "\u24C2", "/Mcircleblack": "\u1F15C", "/Mdot": "\u1E40", "/Mdotaccent": "\u1E40", "/Mdotbelow": "\u1E42", "/Menarmenian": "\u0544", "/Mhook": "\u2C6E", "/Mmonospace": "\uFF2D", "/Mohammad": "\uFDF4", "/Mparens": "\u1F11C", "/Mscript": "\u2133", "/Msmall": "\uF76D", "/Msquare": "\u1F13C", "/Msquareblack": "\u1F17C", "/Mturned": "\u019C", "/Mturnedsmall": "\uA7FA", "/Mu": "\u039C", "/N": "\u004E", "/NJ": "\u01CA", "/Nacute": "\u0143", "/Ncaron": "\u0147", "/Ncedilla": "\u0145", "/Ncircle": "\u24C3", "/Ncircleblack": "\u1F15D", "/Ncircumflexbelow": "\u1E4A", "/Ncommaaccent": "\u0145", "/Ndblstruck": "\u2115", "/Ndescender": "\uA790", "/Ndot": "\u1E44", "/Ndotaccent": "\u1E44", "/Ndotbelow": "\u1E46", "/Ngrave": "\u01F8", "/Nhookleft": "\u019D", "/Nineroman": "\u2168", "/Nj": "\u01CB", "/Njecyr": "\u040A", "/Njecyrillic": "\u040A", "/Njekomicyr": "\u050A", "/Nlinebelow": "\u1E48", "/Nlongrightleg": "\u0220", "/Nmonospace": "\uFF2E", "/Nobliquestroke": "\uA7A4", "/Nowarmenian": "\u0546", "/Nparens": "\u1F11D", "/Nsmall": "\uF76E", "/Nsquare": "\u1F13D", "/Nsquareblack": "\u1F17D", "/Ntilde": "\u00D1", "/Ntildesmall": "\uF7F1", "/Nu": "\u039D", "/O": "\u004F", "/OE": "\u0152", "/OEsmall": "\uF6FA", "/OO": "\uA74E", "/Oacute": "\u00D3", "/Oacutesmall": "\uF7F3", "/Obar": "\u019F", "/Obarcyr": "\u04E8", "/Obardieresiscyr": "\u04EA", "/Obarredcyrillic": "\u04E8", "/Obarreddieresiscyrillic": "\u04EA", "/Obreve": "\u014E", "/Ocaron": "\u01D1", "/Ocenteredtilde": "\u019F", "/Ocircle": "\u24C4", "/Ocircleblack": "\u1F15E", "/Ocircumflex": "\u00D4", "/Ocircumflexacute": "\u1ED0", "/Ocircumflexdotbelow": "\u1ED8", "/Ocircumflexgrave": "\u1ED2", "/Ocircumflexhoi": "\u1ED4", "/Ocircumflexhookabove": "\u1ED4", "/Ocircumflexsmall": "\uF7F4", "/Ocircumflextilde": "\u1ED6", "/Ocyr": "\u041E", "/Ocyrillic": "\u041E", "/Odblacute": "\u0150", "/Odblgrave": "\u020C", "/Odieresis": "\u00D6", "/Odieresiscyr": "\u04E6", "/Odieresiscyrillic": "\u04E6", "/Odieresismacron": "\u022A", "/Odieresissmall": "\uF7F6", "/Odot": "\u022E", "/Odotbelow": "\u1ECC", "/Odotmacron": "\u0230", "/Ogoneksmall": "\uF6FB", "/Ograve": "\u00D2", "/Ogravedbl": "\u020C", "/Ogravesmall": "\uF7F2", "/Oharmenian": "\u0555", "/Ohm": "\u2126", "/Ohoi": "\u1ECE", "/Ohookabove": "\u1ECE", "/Ohorn": "\u01A0", "/Ohornacute": "\u1EDA", "/Ohorndotbelow": "\u1EE2", "/Ohorngrave": "\u1EDC", "/Ohornhoi": "\u1EDE", "/Ohornhookabove": "\u1EDE", "/Ohorntilde": "\u1EE0", "/Ohungarumlaut": "\u0150", "/Oi": "\u01A2", "/Oinvertedbreve": "\u020E", "/Oloop": "\uA74C", "/Omacron": "\u014C", "/Omacronacute": "\u1E52", "/Omacrongrave": "\u1E50", "/Omega": "\u2126", "/Omegaacute": "\u1FFB", "/Omegaasper": "\u1F69", "/Omegaasperacute": "\u1F6D", "/Omegaasperacuteiotasub": "\u1FAD", "/Omegaaspergrave": "\u1F6B", "/Omegaaspergraveiotasub": "\u1FAB", "/Omegaasperiotasub": "\u1FA9", "/Omegaaspertilde": "\u1F6F", "/Omegaaspertildeiotasub": "\u1FAF", "/Omegacyr": "\u0460", "/Omegacyrillic": "\u0460", "/Omegagrave": "\u1FFA", "/Omegagreek": "\u03A9", "/Omegaiotasub": "\u1FFC", "/Omegalenis": "\u1F68", "/Omegalenisacute": "\u1F6C", "/Omegalenisacuteiotasub": "\u1FAC", "/Omegalenisgrave": "\u1F6A", "/Omegalenisgraveiotasub": "\u1FAA", "/Omegalenisiotasub": "\u1FA8", "/Omegalenistilde": "\u1F6E", "/Omegalenistildeiotasub": "\u1FAE", "/Omegaroundcyr": "\u047A", "/Omegaroundcyrillic": "\u047A", "/Omegatitlocyr": "\u047C", "/Omegatitlocyrillic": "\u047C", "/Omegatonos": "\u038F", "/Omicron": "\u039F", "/Omicronacute": "\u1FF9", "/Omicronasper": "\u1F49", "/Omicronasperacute": "\u1F4D", "/Omicronaspergrave": "\u1F4B", "/Omicrongrave": "\u1FF8", "/Omicronlenis": "\u1F48", "/Omicronlenisacute": "\u1F4C", "/Omicronlenisgrave": "\u1F4A", "/Omicrontonos": "\u038C", "/Omonospace": "\uFF2F", "/Oneroman": "\u2160", "/Oogonek": "\u01EA", "/Oogonekmacron": "\u01EC", "/Oopen": "\u0186", "/Oparens": "\u1F11E", "/Oslash": "\u00D8", "/Oslashacute": "\u01FE", "/Oslashsmall": "\uF7F8", "/Osmall": "\uF76F", "/Osquare": "\u1F13E", "/Osquareblack": "\u1F17E", "/Ostroke": "\uA74A", "/Ostrokeacute": "\u01FE", "/Otcyr": "\u047E", "/Otcyrillic": "\u047E", "/Otilde": "\u00D5", "/Otildeacute": "\u1E4C", "/Otildedieresis": "\u1E4E", "/Otildemacron": "\u022C", "/Otildesmall": "\uF7F5", "/Ou": "\u0222", "/P": "\u0050", "/PAsquareblack": "\u1F18C", "/PPVsquare": "\u1F14E", "/Pacute": "\u1E54", "/Palochkacyr": "\u04C0", "/Pcircle": "\u24C5", "/Pcircleblack": "\u1F15F", "/Pcrosssquareblack": "\u1F18A", "/Pdblstruck": "\u2119", "/Pdot": "\u1E56", "/Pdotaccent": "\u1E56", "/Pecyr": "\u041F", "/Pecyrillic": "\u041F", "/Peharmenian": "\u054A", "/Pehookcyr": "\u04A6", "/Pemiddlehookcyrillic": "\u04A6", "/Petailcyr": "\u0524", "/Pflourish": "\uA752", "/Phi": "\u03A6", "/Phook": "\u01A4", "/Pi": "\u03A0", "/Pidblstruck": "\u213F", "/Piwrarmenian": "\u0553", "/Pmonospace": "\uFF30", "/Pparens": "\u1F11F", "/Psi": "\u03A8", "/Psicyr": "\u0470", "/Psicyrillic": "\u0470", "/Psmall": "\uF770", "/Psquare": "\u1F13F", "/Psquareblack": "\u1F17F", "/Pstroke": "\u2C63", "/Pstrokedescender": "\uA750", "/Ptail": "\uA754", "/Q": "\u0051", "/Qacyr": "\u051A", "/QalaUsedAsKoranicStopSign": "\uFDF1", "/Qcircle": "\u24C6", "/Qcircleblack": "\u1F160", "/Qdblstruck": "\u211A", "/Qdiagonalstroke": "\uA758", "/Qmonospace": "\uFF31", "/Qparens": "\u1F120", "/Qrotated": "\u213A", "/Qsmall": "\uF771", "/Qsmallhooktail": "\u024A", "/Qsquare": "\u1F140", "/Qsquareblack": "\u1F180", "/Qstrokedescender": "\uA756", "/R": "\u0052", "/Raarmenian": "\u054C", "/Racute": "\u0154", "/Rasoul": "\uFDF6", "/Rcaron": "\u0158", "/Rcedilla": "\u0156", "/Rcircle": "\u24C7", "/Rcircleblack": "\u1F161", "/Rcommaaccent": "\u0156", "/Rdblgrave": "\u0210", "/Rdblstruck": "\u211D", "/Rdot": "\u1E58", "/Rdotaccent": "\u1E58", "/Rdotbelow": "\u1E5A", "/Rdotbelowmacron": "\u1E5C", "/Reharmenian": "\u0550", "/Reverseddottedsigmalunatesymbol": "\u03FF", "/Reversedzecyr": "\u0510", "/Rfraktur": "\u211C", "/Rgravedbl": "\u0210", "/Rhacyr": "\u0516", "/Rho": "\u03A1", "/Rhoasper": "\u1FEC", "/Ringsmall": "\uF6FC", "/Rinsular": "\uA782", "/Rinvertedbreve": "\u0212", "/Rinvertedsmall": "\u0281", "/Ritaliccircle": "\u1F12C", "/Rlinebelow": "\u1E5E", "/Rmacrondot": "\u1E5C", "/Rmonospace": "\uFF32", "/Robliquestroke": "\uA7A6", "/Rparens": "\u1F121", "/Rrotunda": "\uA75A", "/Rscript": "\u211B", "/Rsmall": "\uF772", "/Rsmallinverted": "\u0281", "/Rsmallinvertedsuperior": "\u02B6", "/Rsquare": "\u1F141", "/Rsquareblack": "\u1F181", "/Rstroke": "\u024C", "/Rsupinvertedmod": "\u02B6", "/Rtail": "\u2C64", "/RubElHizbstart": "\u06DE", "/Rumrotunda": "\uA75C", "/Rumsmall": "\uA776", "/S": "\u0053", "/SAsquareblack": "\u1F18D", "/SDsquare": "\u1F14C", "/SF010000": "\u250C", "/SF020000": "\u2514", "/SF030000": "\u2510", "/SF040000": "\u2518", "/SF050000": "\u253C", "/SF060000": "\u252C", "/SF070000": "\u2534", "/SF080000": "\u251C", "/SF090000": "\u2524", "/SF100000": "\u2500", "/SF110000": "\u2502", "/SF190000": "\u2561", "/SF200000": "\u2562", "/SF210000": "\u2556", "/SF220000": "\u2555", "/SF230000": "\u2563", "/SF240000": "\u2551", "/SF250000": "\u2557", "/SF260000": "\u255D", "/SF270000": "\u255C", "/SF280000": "\u255B", "/SF360000": "\u255E", "/SF370000": "\u255F", "/SF380000": "\u255A", "/SF390000": "\u2554", "/SF400000": "\u2569", "/SF410000": "\u2566", "/SF420000": "\u2560", "/SF430000": "\u2550", "/SF440000": "\u256C", "/SF450000": "\u2567", "/SF460000": "\u2568", "/SF470000": "\u2564", "/SF480000": "\u2565", "/SF490000": "\u2559", "/SF500000": "\u2558", "/SF510000": "\u2552", "/SF520000": "\u2553", "/SF530000": "\u256B", "/SF540000": "\u256A", "/SSsquare": "\u1F14D", "/Sacute": "\u015A", "/Sacutedotaccent": "\u1E64", "/Safha": "\u0603", "/Sajdah": "\u06E9", "/Salam": "\uFDF5", "/Salla": "\uFDF9", "/SallaUsedAsKoranicStopSign": "\uFDF0", "/SallallahouAlayheWasallam": "\uFDFA", "/Saltillo": "\uA78B", "/Sampi": "\u03E0", "/Sampiarchaic": "\u0372", "/Sampigreek": "\u03E0", "/San": "\u03FA", "/Sanah": "\u0601", "/Scaron": "\u0160", "/Scarondot": "\u1E66", "/Scarondotaccent": "\u1E66", "/Scaronsmall": "\uF6FD", "/Scedilla": "\u015E", "/Schwa": "\u018F", "/Schwacyr": "\u04D8", "/Schwacyrillic": "\u04D8", "/Schwadieresiscyr": "\u04DA", "/Schwadieresiscyrillic": "\u04DA", "/Scircle": "\u24C8", "/Scircleblack": "\u1F162", "/Scircumflex": "\u015C", "/Scommaaccent": "\u0218", "/Scriptg": "\uA7AC", "/Sdot": "\u1E60", "/Sdotaccent": "\u1E60", "/Sdotbelow": "\u1E62", "/Sdotbelowdotabove": "\u1E68", "/Sdotbelowdotaccent": "\u1E68", "/Seharmenian": "\u054D", "/Semisoftcyr": "\u048C", "/Sevenroman": "\u2166", "/Shaarmenian": "\u0547", "/Shacyr": "\u0428", "/Shacyrillic": "\u0428", "/Shchacyr": "\u0429", "/Shchacyrillic": "\u0429", "/Sheicoptic": "\u03E2", "/SheneGerishin:hb": "\u059E", "/Shhacyr": "\u04BA", "/Shhacyrillic": "\u04BA", "/Shhatailcyr": "\u0526", "/Shimacoptic": "\u03EC", "/Sho": "\u03F7", "/Sigma": "\u03A3", "/Sigmalunatesymbol": "\u03F9", "/Sigmalunatesymboldotted": "\u03FE", "/Sigmareversedlunatesymbol": "\u03FD", "/Sinsular": "\uA784", "/Sixroman": "\u2165", "/Sjekomicyr": "\u050C", "/Smonospace": "\uFF33", "/Sobliquestroke": "\uA7A8", "/Softcyr": "\u042C", "/Softsigncyrillic": "\u042C", "/Sparens": "\u1F122", "/Sshell": "\u1F12A", "/Ssmall": "\uF773", "/Ssquare": "\u1F142", "/Ssquareblack": "\u1F182", "/Sswashtail": "\u2C7E", "/Stigma": "\u03DA", "/Stigmagreek": "\u03DA", "/T": "\u0054", "/Tau": "\u03A4", "/Tbar": "\u0166", "/Tcaron": "\u0164", "/Tcedilla": "\u0162", "/Tcircle": "\u24C9", "/Tcircleblack": "\u1F163", "/Tcircumflexbelow": "\u1E70", "/Tcommaaccent": "\u0162", "/Tdot": "\u1E6A", "/Tdotaccent": "\u1E6A", "/Tdotbelow": "\u1E6C", "/Tecyr": "\u0422", "/Tecyrillic": "\u0422", "/Tedescendercyrillic": "\u04AC", "/Tenroman": "\u2169", "/Tetailcyr": "\u04AC", "/Tetsecyr": "\u04B4", "/Tetsecyrillic": "\u04B4", "/Theta": "\u0398", "/Thetasymbol": "\u03F4", "/Thook": "\u01AC", "/Thorn": "\u00DE", "/Thornsmall": "\uF7FE", "/Thornstroke": "\uA764", "/Thornstrokedescender": "\uA766", "/Threeroman": "\u2162", "/Tildesmall": "\uF6FE", "/Tinsular": "\uA786", "/Tiwnarmenian": "\u054F", "/Tjekomicyr": "\u050E", "/Tlinebelow": "\u1E6E", "/Tmonospace": "\uFF34", "/Toarmenian": "\u0539", "/Tonefive": "\u01BC", "/Tonesix": "\u0184", "/Tonetwo": "\u01A7", "/Tparens": "\u1F123", "/Tresillo": "\uA72A", "/Tretroflexhook": "\u01AE", "/Tsecyr": "\u0426", "/Tsecyrillic": "\u0426", "/Tshecyr": "\u040B", "/Tshecyrillic": "\u040B", "/Tsmall": "\uF774", "/Tsquare": "\u1F143", "/Tsquareblack": "\u1F183", "/Tturned": "\uA7B1", "/Twelveroman": "\u216B", "/Twithdiagonalstroke": "\u023E", "/Tworoman": "\u2161", "/Tz": "\uA728", "/U": "\u0055", "/Uacute": "\u00DA", "/Uacutedblcyr": "\u04F2", "/Uacutesmall": "\uF7FA", "/Ubar": "\u0244", "/Ubreve": "\u016C", "/Ucaron": "\u01D3", "/Ucircle": "\u24CA", "/Ucircleblack": "\u1F164", "/Ucircumflex": "\u00DB", "/Ucircumflexbelow": "\u1E76", "/Ucircumflexsmall": "\uF7FB", "/Ucyr": "\u0423", "/Ucyrillic": "\u0423", "/Udblacute": "\u0170", "/Udblgrave": "\u0214", "/Udieresis": "\u00DC", "/Udieresisacute": "\u01D7", "/Udieresisbelow": "\u1E72", "/Udieresiscaron": "\u01D9", "/Udieresiscyr": "\u04F0", "/Udieresiscyrillic": "\u04F0", "/Udieresisgrave": "\u01DB", "/Udieresismacron": "\u01D5", "/Udieresissmall": "\uF7FC", "/Udotbelow": "\u1EE4", "/Ugrave": "\u00D9", "/Ugravedbl": "\u0214", "/Ugravesmall": "\uF7F9", "/Uhoi": "\u1EE6", "/Uhookabove": "\u1EE6", "/Uhorn": "\u01AF", "/Uhornacute": "\u1EE8", "/Uhorndotbelow": "\u1EF0", "/Uhorngrave": "\u1EEA", "/Uhornhoi": "\u1EEC", "/Uhornhookabove": "\u1EEC", "/Uhorntilde": "\u1EEE", "/Uhungarumlaut": "\u0170", "/Uhungarumlautcyrillic": "\u04F2", "/Uinvertedbreve": "\u0216", "/Ukcyr": "\u0478", "/Ukcyrillic": "\u0478", "/Umacron": "\u016A", "/Umacroncyr": "\u04EE", "/Umacroncyrillic": "\u04EE", "/Umacrondieresis": "\u1E7A", "/Umonospace": "\uFF35", "/Uogonek": "\u0172", "/Uparens": "\u1F124", "/Upsilon": "\u03A5", "/Upsilon1": "\u03D2", "/Upsilonacute": "\u1FEB", "/Upsilonacutehooksymbol": "\u03D3", "/Upsilonacutehooksymbolgreek": "\u03D3", "/Upsilonadieresishooksymbol": "\u03D4", "/Upsilonafrican": "\u01B1", "/Upsilonasper": "\u1F59", "/Upsilonasperacute": "\u1F5D", "/Upsilonaspergrave": "\u1F5B", "/Upsilonaspertilde": "\u1F5F", "/Upsilonbreve": "\u1FE8", "/Upsilondieresis": "\u03AB", "/Upsilondieresishooksymbolgreek": "\u03D4", "/Upsilongrave": "\u1FEA", "/Upsilonhooksymbol": "\u03D2", "/Upsilontonos": "\u038E", "/Upsilonwithmacron": "\u1FE9", "/Uring": "\u016E", "/Ushortcyr": "\u040E", "/Ushortcyrillic": "\u040E", "/Usmall": "\uF775", "/Usquare": "\u1F144", "/Usquareblack": "\u1F184", "/Ustraightcyr": "\u04AE", "/Ustraightcyrillic": "\u04AE", "/Ustraightstrokecyr": "\u04B0", "/Ustraightstrokecyrillic": "\u04B0", "/Utilde": "\u0168", "/Utildeacute": "\u1E78", "/Utildebelow": "\u1E74", "/V": "\u0056", "/Vcircle": "\u24CB", "/Vcircleblack": "\u1F165", "/Vdiagonalstroke": "\uA75E", "/Vdotbelow": "\u1E7E", "/Vecyr": "\u0412", "/Vecyrillic": "\u0412", "/Vend": "\uA768", "/Vewarmenian": "\u054E", "/Vhook": "\u01B2", "/Visigothicz": "\uA762", "/Vmod": "\u2C7D", "/Vmonospace": "\uFF36", "/Voarmenian": "\u0548", "/Volapukae": "\uA79A", "/Volapukoe": "\uA79C", "/Volapukue": "\uA79E", "/Vparens": "\u1F125", "/Vsmall": "\uF776", "/Vsquare": "\u1F145", "/Vsquareblack": "\u1F185", "/Vtilde": "\u1E7C", "/Vturned": "\u0245", "/Vwelsh": "\u1EFC", "/Vy": "\uA760", "/W": "\u0057", "/WZcircle": "\u1F12E", "/Wacute": "\u1E82", "/Wasallam": "\uFDF8", "/Wcircle": "\u24CC", "/Wcircleblack": "\u1F166", "/Wcircumflex": "\u0174", "/Wdieresis": "\u1E84", "/Wdot": "\u1E86", "/Wdotaccent": "\u1E86", "/Wdotbelow": "\u1E88", "/Wecyr": "\u051C", "/Wgrave": "\u1E80", "/Whook": "\u2C72", "/Wmonospace": "\uFF37", "/Wparens": "\u1F126", "/Wsmall": "\uF777", "/Wsquare": "\u1F146", "/Wsquareblack": "\u1F186", "/Wynn": "\u01F7", "/X": "\u0058", "/Xatailcyr": "\u04B2", "/Xcircle": "\u24CD", "/Xcircleblack": "\u1F167", "/Xdieresis": "\u1E8C", "/Xdot": "\u1E8A", "/Xdotaccent": "\u1E8A", "/Xeharmenian": "\u053D", "/Xi": "\u039E", "/Xmonospace": "\uFF38", "/Xparens": "\u1F127", "/Xsmall": "\uF778", "/Xsquare": "\u1F147", "/Xsquareblack": "\u1F187", "/Y": "\u0059", "/Yacute": "\u00DD", "/Yacutesmall": "\uF7FD", "/Yacyr": "\u042F", "/Yaecyr": "\u0518", "/Yatcyr": "\u0462", "/Yatcyrillic": "\u0462", "/Ycircle": "\u24CE", "/Ycircleblack": "\u1F168", "/Ycircumflex": "\u0176", "/Ydieresis": "\u0178", "/Ydieresissmall": "\uF7FF", "/Ydot": "\u1E8E", "/Ydotaccent": "\u1E8E", "/Ydotbelow": "\u1EF4", "/Yericyrillic": "\u042B", "/Yerudieresiscyrillic": "\u04F8", "/Ygrave": "\u1EF2", "/Yhoi": "\u1EF6", "/Yhook": "\u01B3", "/Yhookabove": "\u1EF6", "/Yiarmenian": "\u0545", "/Yicyrillic": "\u0407", "/Yiwnarmenian": "\u0552", "/Ylongcyr": "\u042B", "/Ylongdieresiscyr": "\u04F8", "/Yloop": "\u1EFE", "/Ymacron": "\u0232", "/Ymonospace": "\uFF39", "/Yogh": "\u021C", "/Yot": "\u037F", "/Yparens": "\u1F128", "/Ysmall": "\uF779", "/Ysquare": "\u1F148", "/Ysquareblack": "\u1F188", "/Ystroke": "\u024E", "/Ytilde": "\u1EF8", "/Yturnedsans": "\u2144", "/Yucyr": "\u042E", "/Yukrcyr": "\u0407", "/Yusbigcyr": "\u046A", "/Yusbigcyrillic": "\u046A", "/Yusbigiotifiedcyr": "\u046C", "/Yusbigiotifiedcyrillic": "\u046C", "/Yuslittlecyr": "\u0466", "/Yuslittlecyrillic": "\u0466", "/Yuslittleiotifiedcyr": "\u0468", "/Yuslittleiotifiedcyrillic": "\u0468", "/Z": "\u005A", "/Zaarmenian": "\u0536", "/Zacute": "\u0179", "/Zcaron": "\u017D", "/Zcaronsmall": "\uF6FF", "/Zcircle": "\u24CF", "/Zcircleblack": "\u1F169", "/Zcircumflex": "\u1E90", "/Zdblstruck": "\u2124", "/Zdescender": "\u2C6B", "/Zdot": "\u017B", "/Zdotaccent": "\u017B", "/Zdotbelow": "\u1E92", "/Zecyr": "\u0417", "/Zecyrillic": "\u0417", "/Zedescendercyrillic": "\u0498", "/Zedieresiscyr": "\u04DE", "/Zedieresiscyrillic": "\u04DE", "/Zeta": "\u0396", "/Zetailcyr": "\u0498", "/Zfraktur": "\u2128", "/Zhearmenian": "\u053A", "/Zhebrevecyr": "\u04C1", "/Zhebrevecyrillic": "\u04C1", "/Zhecyr": "\u0416", "/Zhecyrillic": "\u0416", "/Zhedescendercyrillic": "\u0496", "/Zhedieresiscyr": "\u04DC", "/Zhedieresiscyrillic": "\u04DC", "/Zhetailcyr": "\u0496", "/Zhook": "\u0224", "/Zjekomicyr": "\u0504", "/Zlinebelow": "\u1E94", "/Zmonospace": "\uFF3A", "/Zparens": "\u1F129", "/Zsmall": "\uF77A", "/Zsquare": "\u1F149", "/Zsquareblack": "\u1F189", "/Zstroke": "\u01B5", "/Zswashtail": "\u2C7F", "/a": "\u0061", "/a.inferior": "\u2090", "/aHonRAA": "\u0613", "/aa": "\uA733", "/aabengali": "\u0986", "/aacute": "\u00E1", "/aadeva": "\u0906", "/aagujarati": "\u0A86", "/aagurmukhi": "\u0A06", "/aamatragurmukhi": "\u0A3E", "/aarusquare": "\u3303", "/aavowelsignbengali": "\u09BE", "/aavowelsigndeva": "\u093E", "/aavowelsigngujarati": "\u0ABE", "/abbreviationmarkarmenian": "\u055F", "/abbreviationsigndeva": "\u0970", "/abengali": "\u0985", "/abopomofo": "\u311A", "/abreve": "\u0103", "/abreveacute": "\u1EAF", "/abrevecyr": "\u04D1", "/abrevecyrillic": "\u04D1", "/abrevedotbelow": "\u1EB7", "/abrevegrave": "\u1EB1", "/abrevehoi": "\u1EB3", "/abrevehookabove": "\u1EB3", "/abrevetilde": "\u1EB5", "/absquareblack": "\u1F18E", "/acaron": "\u01CE", "/accountof": "\u2100", "/accurrent": "\u23E6", "/acircle": "\u24D0", "/acirclekatakana": "\u32D0", "/acircumflex": "\u00E2", "/acircumflexacute": "\u1EA5", "/acircumflexdotbelow": "\u1EAD", "/acircumflexgrave": "\u1EA7", "/acircumflexhoi": "\u1EA9", "/acircumflexhookabove": "\u1EA9", "/acircumflextilde": "\u1EAB", "/activatearabicformshaping": "\u206D", "/activatesymmetricswapping": "\u206B", "/acute": "\u00B4", "/acutebelowcmb": "\u0317", "/acutecmb": "\u0301", "/acutecomb": "\u0301", "/acutedblmiddlemod": "\u02F6", "/acutedeva": "\u0954", "/acutelowmod": "\u02CF", "/acutemod": "\u02CA", "/acutetonecmb": "\u0341", "/acyr": "\u0430", "/acyrillic": "\u0430", "/adblgrave": "\u0201", "/addakgurmukhi": "\u0A71", "/addressedsubject": "\u2101", "/adegadegpada": "\uA9CB", "/adegpada": "\uA9CA", "/adeva": "\u0905", "/adieresis": "\u00E4", "/adieresiscyr": "\u04D3", "/adieresiscyrillic": "\u04D3", "/adieresismacron": "\u01DF", "/adishakti": "\u262C", "/admissionTickets": "\u1F39F", "/adot": "\u0227", "/adotbelow": "\u1EA1", "/adotmacron": "\u01E1", "/ae": "\u00E6", "/aeacute": "\u01FD", "/aekorean": "\u3150", "/aemacron": "\u01E3", "/aerialTramway": "\u1F6A1", "/afghani": "\u060B", "/afii00208": "\u2015", "/afii08941": "\u20A4", "/afii10017": "\u0410", "/afii10018": "\u0411", "/afii10019": "\u0412", "/afii10020": "\u0413", "/afii10021": "\u0414", "/afii10022": "\u0415", "/afii10023": "\u0401", "/afii10024": "\u0416", "/afii10025": "\u0417", "/afii10026": "\u0418", "/afii10027": "\u0419", "/afii10028": "\u041A", "/afii10029": "\u041B", "/afii10030": "\u041C", "/afii10031": "\u041D", "/afii10032": "\u041E", "/afii10033": "\u041F", "/afii10034": "\u0420", "/afii10035": "\u0421", "/afii10036": "\u0422", "/afii10037": "\u0423", "/afii10038": "\u0424", "/afii10039": "\u0425", "/afii10040": "\u0426", "/afii10041": "\u0427", "/afii10042": "\u0428", "/afii10043": "\u0429", "/afii10044": "\u042A", "/afii10045": "\u042B", "/afii10046": "\u042C", "/afii10047": "\u042D", "/afii10048": "\u042E", "/afii10049": "\u042F", "/afii10050": "\u0490", "/afii10051": "\u0402", "/afii10052": "\u0403", "/afii10053": "\u0404", "/afii10054": "\u0405", "/afii10055": "\u0406", "/afii10056": "\u0407", "/afii10057": "\u0408", "/afii10058": "\u0409", "/afii10059": "\u040A", "/afii10060": "\u040B", "/afii10061": "\u040C", "/afii10062": "\u040E", "/afii10063": "\uF6C4", "/afii10064": "\uF6C5", "/afii10065": "\u0430", "/afii10066": "\u0431", "/afii10067": "\u0432", "/afii10068": "\u0433", "/afii10069": "\u0434", "/afii10070": "\u0435", "/afii10071": "\u0451", "/afii10072": "\u0436", "/afii10073": "\u0437", "/afii10074": "\u0438", "/afii10075": "\u0439", "/afii10076": "\u043A", "/afii10077": "\u043B", "/afii10078": "\u043C", "/afii10079": "\u043D", "/afii10080": "\u043E", "/afii10081": "\u043F", "/afii10082": "\u0440", "/afii10083": "\u0441", "/afii10084": "\u0442", "/afii10085": "\u0443", "/afii10086": "\u0444", "/afii10087": "\u0445", "/afii10088": "\u0446", "/afii10089": "\u0447", "/afii10090": "\u0448", "/afii10091": "\u0449", "/afii10092": "\u044A", "/afii10093": "\u044B", "/afii10094": "\u044C", "/afii10095": "\u044D", "/afii10096": "\u044E", "/afii10097": "\u044F", "/afii10098": "\u0491", "/afii10099": "\u0452", "/afii10100": "\u0453", "/afii10101": "\u0454", "/afii10102": "\u0455", "/afii10103": "\u0456", "/afii10104": "\u0457", "/afii10105": "\u0458", "/afii10106": "\u0459", "/afii10107": "\u045A", "/afii10108": "\u045B", "/afii10109": "\u045C", "/afii10110": "\u045E", "/afii10145": "\u040F", "/afii10146": "\u0462", "/afii10147": "\u0472", "/afii10148": "\u0474", "/afii10192": "\uF6C6", "/afii10193": "\u045F", "/afii10194": "\u0463", "/afii10195": "\u0473", "/afii10196": "\u0475", "/afii10831": "\uF6C7", "/afii10832": "\uF6C8", "/afii10846": "\u04D9", "/afii299": "\u200E", "/afii300": "\u200F", "/afii301": "\u200D", "/afii57381": "\u066A", "/afii57388": "\u060C", "/afii57392": "\u0660", "/afii57393": "\u0661", "/afii57394": "\u0662", "/afii57395": "\u0663", "/afii57396": "\u0664", "/afii57397": "\u0665", "/afii57398": "\u0666", "/afii57399": "\u0667", "/afii57400": "\u0668", "/afii57401": "\u0669", "/afii57403": "\u061B", "/afii57407": "\u061F", "/afii57409": "\u0621", "/afii57410": "\u0622", "/afii57411": "\u0623", "/afii57412": "\u0624", "/afii57413": "\u0625", "/afii57414": "\u0626", "/afii57415": "\u0627", "/afii57416": "\u0628", "/afii57417": "\u0629", "/afii57418": "\u062A", "/afii57419": "\u062B", "/afii57420": "\u062C", "/afii57421": "\u062D", "/afii57422": "\u062E", "/afii57423": "\u062F", "/afii57424": "\u0630", "/afii57425": "\u0631", "/afii57426": "\u0632", "/afii57427": "\u0633", "/afii57428": "\u0634", "/afii57429": "\u0635", "/afii57430": "\u0636", "/afii57431": "\u0637", "/afii57432": "\u0638", "/afii57433": "\u0639", "/afii57434": "\u063A", "/afii57440": "\u0640", "/afii57441": "\u0641", "/afii57442": "\u0642", "/afii57443": "\u0643", "/afii57444": "\u0644", "/afii57445": "\u0645", "/afii57446": "\u0646", "/afii57448": "\u0648", "/afii57449": "\u0649", "/afii57450": "\u064A", "/afii57451": "\u064B", "/afii57452": "\u064C", "/afii57453": "\u064D", "/afii57454": "\u064E", "/afii57455": "\u064F", "/afii57456": "\u0650", "/afii57457": "\u0651", "/afii57458": "\u0652", "/afii57470": "\u0647", "/afii57505": "\u06A4", "/afii57506": "\u067E", "/afii57507": "\u0686", "/afii57508": "\u0698", "/afii57509": "\u06AF", "/afii57511": "\u0679", "/afii57512": "\u0688", "/afii57513": "\u0691", "/afii57514": "\u06BA", "/afii57519": "\u06D2", "/afii57534": "\u06D5", "/afii57636": "\u20AA", "/afii57645": "\u05BE", "/afii57658": "\u05C3", "/afii57664": "\u05D0", "/afii57665": "\u05D1", "/afii57666": "\u05D2", "/afii57667": "\u05D3", "/afii57668": "\u05D4", "/afii57669": "\u05D5", "/afii57670": "\u05D6", "/afii57671": "\u05D7", "/afii57672": "\u05D8", "/afii57673": "\u05D9", "/afii57674": "\u05DA", "/afii57675": "\u05DB", "/afii57676": "\u05DC", "/afii57677": "\u05DD", "/afii57678": "\u05DE", "/afii57679": "\u05DF", "/afii57680": "\u05E0", "/afii57681": "\u05E1", "/afii57682": "\u05E2", "/afii57683": "\u05E3", "/afii57684": "\u05E4", "/afii57685": "\u05E5", "/afii57686": "\u05E6", "/afii57687": "\u05E7", "/afii57688": "\u05E8", "/afii57689": "\u05E9", "/afii57690": "\u05EA", "/afii57694": "\uFB2A", "/afii57695": "\uFB2B", "/afii57700": "\uFB4B", "/afii57705": "\uFB1F", "/afii57716": "\u05F0", "/afii57717": "\u05F1", "/afii57718": "\u05F2", "/afii57723": "\uFB35", "/afii57793": "\u05B4", "/afii57794": "\u05B5", "/afii57795": "\u05B6", "/afii57796": "\u05BB", "/afii57797": "\u05B8", "/afii57798": "\u05B7", "/afii57799": "\u05B0", "/afii57800": "\u05B2", "/afii57801": "\u05B1", "/afii57802": "\u05B3", "/afii57803": "\u05C2", "/afii57804": "\u05C1", "/afii57806": "\u05B9", "/afii57807": "\u05BC", "/afii57839": "\u05BD", "/afii57841": "\u05BF", "/afii57842": "\u05C0", "/afii57929": "\u02BC", "/afii61248": "\u2105", "/afii61289": "\u2113", "/afii61352": "\u2116", "/afii61573": "\u202C", "/afii61574": "\u202D", "/afii61575": "\u202E", "/afii61664": "\u200C", "/afii63167": "\u066D", "/afii64937": "\u02BD", "/agrave": "\u00E0", "/agravedbl": "\u0201", "/agujarati": "\u0A85", "/agurmukhi": "\u0A05", "/ahiragana": "\u3042", "/ahoi": "\u1EA3", "/ahookabove": "\u1EA3", "/aibengali": "\u0990", "/aibopomofo": "\u311E", "/aideva": "\u0910", "/aiecyr": "\u04D5", "/aiecyrillic": "\u04D5", "/aigujarati": "\u0A90", "/aigurmukhi": "\u0A10", "/aimatragurmukhi": "\u0A48", "/ain.fina": "\uFECA", "/ain.init": "\uFECB", "/ain.init_alefmaksura.fina": "\uFCF7", "/ain.init_jeem.fina": "\uFC29", "/ain.init_jeem.medi": "\uFCBA", "/ain.init_jeem.medi_meem.medi": "\uFDC4", "/ain.init_meem.fina": "\uFC2A", "/ain.init_meem.medi": "\uFCBB", "/ain.init_meem.medi_meem.medi": "\uFD77", "/ain.init_yeh.fina": "\uFCF8", "/ain.isol": "\uFEC9", "/ain.medi": "\uFECC", "/ain.medi_alefmaksura.fina": "\uFD13", "/ain.medi_jeem.medi_meem.fina": "\uFD75", "/ain.medi_meem.medi_alefmaksura.fina": "\uFD78", "/ain.medi_meem.medi_meem.fina": "\uFD76", "/ain.medi_meem.medi_yeh.fina": "\uFDB6", "/ain.medi_yeh.fina": "\uFD14", "/ainThreeDotsDownAbove": "\u075E", "/ainTwoDotsAbove": "\u075D", "/ainTwoDotsVerticallyAbove": "\u075F", "/ainarabic": "\u0639", "/ainfinalarabic": "\uFECA", "/aininitialarabic": "\uFECB", "/ainmedialarabic": "\uFECC", "/ainthreedotsabove": "\u06A0", "/ainvertedbreve": "\u0203", "/airplaneArriving": "\u1F6EC", "/airplaneDeparture": "\u1F6EB", "/aivowelsignbengali": "\u09C8", "/aivowelsigndeva": "\u0948", "/aivowelsigngujarati": "\u0AC8", "/akatakana": "\u30A2", "/akatakanahalfwidth": "\uFF71", "/akorean": "\u314F", "/aktieselskab": "\u214D", "/alarmclock": "\u23F0", "/alef": "\u05D0", "/alef.fina": "\uFE8E", "/alef.init_fathatan.fina": "\uFD3D", "/alef.isol": "\uFE8D", "/alef.medi_fathatan.fina": "\uFD3C", "/alef:hb": "\u05D0", "/alefDigitThreeAbove": "\u0774", "/alefDigitTwoAbove": "\u0773", "/alefLamYehabove": "\u0616", "/alefabove": "\u0670", "/alefarabic": "\u0627", "/alefdageshhebrew": "\uFB30", "/aleffinalarabic": "\uFE8E", "/alefhamza": "\u0623", "/alefhamza.fina": "\uFE84", "/alefhamza.isol": "\uFE83", "/alefhamzaabovearabic": "\u0623", "/alefhamzaabovefinalarabic": "\uFE84", "/alefhamzabelow": "\u0625", "/alefhamzabelow.fina": "\uFE88", "/alefhamzabelow.isol": "\uFE87", "/alefhamzabelowarabic": "\u0625", "/alefhamzabelowfinalarabic": "\uFE88", "/alefhebrew": "\u05D0", "/alefhighhamza": "\u0675", "/aleflamedhebrew": "\uFB4F", "/alefmadda": "\u0622", "/alefmadda.fina": "\uFE82", "/alefmadda.isol": "\uFE81", "/alefmaddaabovearabic": "\u0622", "/alefmaddaabovefinalarabic": "\uFE82", "/alefmaksura": "\u0649", "/alefmaksura.fina": "\uFEF0", "/alefmaksura.init_superscriptalef.fina": "\uFC5D", "/alefmaksura.isol": "\uFEEF", "/alefmaksura.medi_superscriptalef.fina": "\uFC90", "/alefmaksuraarabic": "\u0649", "/alefmaksurafinalarabic": "\uFEF0", "/alefmaksurainitialarabic": "\uFEF3", "/alefmaksuramedialarabic": "\uFEF4", "/alefpatahhebrew": "\uFB2E", "/alefqamatshebrew": "\uFB2F", "/alefwasla": "\u0671", "/alefwasla.fina": "\uFB51", "/alefwasla.isol": "\uFB50", "/alefwavyhamza": "\u0672", "/alefwavyhamzabelow": "\u0673", "/alefwide:hb": "\uFB21", "/alefwithmapiq:hb": "\uFB30", "/alefwithpatah:hb": "\uFB2E", "/alefwithqamats:hb": "\uFB2F", "/alembic": "\u2697", "/aleph": "\u2135", "/alienMonster": "\u1F47E", "/allaroundprofile": "\u232E", "/allequal": "\u224C", "/allianceideographiccircled": "\u32AF", "/allianceideographicparen": "\u323F", "/almostequalorequal": "\u224A", "/alpha": "\u03B1", "/alphaacute": "\u1F71", "/alphaacuteiotasub": "\u1FB4", "/alphaasper": "\u1F01", "/alphaasperacute": "\u1F05", "/alphaasperacuteiotasub": "\u1F85", "/alphaaspergrave": "\u1F03", "/alphaaspergraveiotasub": "\u1F83", "/alphaasperiotasub": "\u1F81", "/alphaaspertilde": "\u1F07", "/alphaaspertildeiotasub": "\u1F87", "/alphabreve": "\u1FB0", "/alphafunc": "\u237A", "/alphagrave": "\u1F70", "/alphagraveiotasub": "\u1FB2", "/alphaiotasub": "\u1FB3", "/alphalenis": "\u1F00", "/alphalenisacute": "\u1F04", "/alphalenisacuteiotasub": "\u1F84", "/alphalenisgrave": "\u1F02", "/alphalenisgraveiotasub": "\u1F82", "/alphalenisiotasub": "\u1F80", "/alphalenistilde": "\u1F06", "/alphalenistildeiotasub": "\u1F86", "/alphatilde": "\u1FB6", "/alphatildeiotasub": "\u1FB7", "/alphatonos": "\u03AC", "/alphaturned": "\u0252", "/alphaunderlinefunc": "\u2376", "/alphawithmacron": "\u1FB1", "/alternateonewayleftwaytraffic": "\u26D5", "/alternative": "\u2387", "/amacron": "\u0101", "/ambulance": "\u1F691", "/americanFootball": "\u1F3C8", "/amfullwidth": "\u33C2", "/amonospace": "\uFF41", "/amountofcheck": "\u2447", "/ampersand": "\u0026", "/ampersandSindhi": "\u06FD", "/ampersandmonospace": "\uFF06", "/ampersandsmall": "\uF726", "/ampersandturned": "\u214B", "/amphora": "\u1F3FA", "/amsquare": "\u33C2", "/anbopomofo": "\u3122", "/anchor": "\u2693", "/ancoradown": "\u2E14", "/ancoraup": "\u2E15", "/andappada": "\uA9C3", "/angbopomofo": "\u3124", "/anger": "\u1F4A2", "/angkhankhuthai": "\u0E5A", "/angle": "\u2220", "/anglearcright": "\u22BE", "/anglebracketleft": "\u3008", "/anglebracketleftvertical": "\uFE3F", "/anglebracketright": "\u3009", "/anglebracketrightvertical": "\uFE40", "/angledottedright": "\u2E16", "/angleleft": "\u2329", "/anglemarkerdottedsubstitutionright": "\u2E01", "/anglemarkersubstitutionright": "\u2E00", "/angleright": "\u232A", "/anglezigzagarrowdownright": "\u237C", "/angryFace": "\u1F620", "/angstrom": "\u212B", "/anguishedFace": "\u1F627", "/ankh": "\u2625", "/anoteleia": "\u0387", "/anpeasquare": "\u3302", "/ant": "\u1F41C", "/antennaBars": "\u1F4F6", "/anticlockwiseDownwardsAndUpwardsOpenCircleArrows": "\u1F504", "/anudattadeva": "\u0952", "/anusvarabengali": "\u0982", "/anusvaradeva": "\u0902", "/anusvaragujarati": "\u0A82", "/ao": "\uA735", "/aogonek": "\u0105", "/aovermfullwidth": "\u33DF", "/apaatosquare": "\u3300", "/aparen": "\u249C", "/aparenthesized": "\u249C", "/apostrophearmenian": "\u055A", "/apostrophedblmod": "\u02EE", "/apostrophemod": "\u02BC", "/apple": "\uF8FF", "/approaches": "\u2250", "/approacheslimit": "\u2250", "/approxequal": "\u2248", "/approxequalorimage": "\u2252", "/approximatelybutnotactuallyequal": "\u2246", "/approximatelyequal": "\u2245", "/approximatelyequalorimage": "\u2252", "/apriltelegraph": "\u32C3", "/aquarius": "\u2652", "/ar:ae": "\u06D5", "/ar:ain": "\u0639", "/ar:alef": "\u0627", "/ar:comma": "\u060C", "/ar:cuberoot": "\u0606", "/ar:decimalseparator": "\u066B", "/ar:e": "\u06D0", "/ar:eight": "\u0668", "/ar:feh": "\u0641", "/ar:five": "\u0665", "/ar:four": "\u0664", "/ar:fourthroot": "\u0607", "/ar:kaf": "\u0643", "/ar:ng": "\u06AD", "/ar:nine": "\u0669", "/ar:numbersign": "\u0600", "/ar:oe": "\u06C6", "/ar:one": "\u0661", "/ar:peh": "\u067E", "/ar:percent": "\u066A", "/ar:perthousand": "\u060A", "/ar:question": "\u061F", "/ar:reh": "\u0631", "/ar:semicolon": "\u061B", "/ar:seven": "\u0667", "/ar:shadda": "\u0651", "/ar:six": "\u0666", "/ar:sukun": "\u0652", "/ar:three": "\u0663", "/ar:two": "\u0662", "/ar:u": "\u06C7", "/ar:ve": "\u06CB", "/ar:yu": "\u06C8", "/ar:zero": "\u0660", "/araeaekorean": "\u318E", "/araeakorean": "\u318D", "/arc": "\u2312", "/archaicmepigraphic": "\uA7FF", "/aries": "\u2648", "/arighthalfring": "\u1E9A", "/aring": "\u00E5", "/aringacute": "\u01FB", "/aringbelow": "\u1E01", "/armn:Ayb": "\u0531", "/armn:Ben": "\u0532", "/armn:Ca": "\u053E", "/armn:Cha": "\u0549", "/armn:Cheh": "\u0543", "/armn:Co": "\u0551", "/armn:DRAMSIGN": "\u058F", "/armn:Da": "\u0534", "/armn:Ech": "\u0535", "/armn:Eh": "\u0537", "/armn:Et": "\u0538", "/armn:Feh": "\u0556", "/armn:Ghad": "\u0542", "/armn:Gim": "\u0533", "/armn:Ho": "\u0540", "/armn:Ini": "\u053B", "/armn:Ja": "\u0541", "/armn:Jheh": "\u054B", "/armn:Keh": "\u0554", "/armn:Ken": "\u053F", "/armn:Liwn": "\u053C", "/armn:Men": "\u0544", "/armn:Now": "\u0546", "/armn:Oh": "\u0555", "/armn:Peh": "\u054A", "/armn:Piwr": "\u0553", "/armn:Ra": "\u054C", "/armn:Reh": "\u0550", "/armn:Seh": "\u054D", "/armn:Sha": "\u0547", "/armn:Tiwn": "\u054F", "/armn:To": "\u0539", "/armn:Vew": "\u054E", "/armn:Vo": "\u0548", "/armn:Xeh": "\u053D", "/armn:Yi": "\u0545", "/armn:Yiwn": "\u0552", "/armn:Za": "\u0536", "/armn:Zhe": "\u053A", "/armn:abbreviationmark": "\u055F", "/armn:apostrophe": "\u055A", "/armn:ayb": "\u0561", "/armn:ben": "\u0562", "/armn:ca": "\u056E", "/armn:cha": "\u0579", "/armn:cheh": "\u0573", "/armn:co": "\u0581", "/armn:comma": "\u055D", "/armn:da": "\u0564", "/armn:ech": "\u0565", "/armn:ech_yiwn": "\u0587", "/armn:eh": "\u0567", "/armn:emphasismark": "\u055B", "/armn:et": "\u0568", "/armn:exclam": "\u055C", "/armn:feh": "\u0586", "/armn:ghad": "\u0572", "/armn:gim": "\u0563", "/armn:ho": "\u0570", "/armn:hyphen": "\u058A", "/armn:ini": "\u056B", "/armn:ja": "\u0571", "/armn:jheh": "\u057B", "/armn:keh": "\u0584", "/armn:ken": "\u056F", "/armn:leftfacingeternitysign": "\u058E", "/armn:liwn": "\u056C", "/armn:men": "\u0574", "/armn:men_ech": "\uFB14", "/armn:men_ini": "\uFB15", "/armn:men_now": "\uFB13", "/armn:men_xeh": "\uFB17", "/armn:now": "\u0576", "/armn:oh": "\u0585", "/armn:peh": "\u057A", "/armn:period": "\u0589", "/armn:piwr": "\u0583", "/armn:question": "\u055E", "/armn:ra": "\u057C", "/armn:reh": "\u0580", "/armn:rightfacingeternitysign": "\u058D", "/armn:ringhalfleft": "\u0559", "/armn:seh": "\u057D", "/armn:sha": "\u0577", "/armn:tiwn": "\u057F", "/armn:to": "\u0569", "/armn:vew": "\u057E", "/armn:vew_now": "\uFB16", "/armn:vo": "\u0578", "/armn:xeh": "\u056D", "/armn:yi": "\u0575", "/armn:yiwn": "\u0582", "/armn:za": "\u0566", "/armn:zhe": "\u056A", "/arrowNE": "\u2197", "/arrowNW": "\u2196", "/arrowSE": "\u2198", "/arrowSW": "\u2199", "/arrowanticlockwiseopencircle": "\u21BA", "/arrowanticlockwisesemicircle": "\u21B6", "/arrowboth": "\u2194", "/arrowclockwiseopencircle": "\u21BB", "/arrowclockwisesemicircle": "\u21B7", "/arrowdashdown": "\u21E3", "/arrowdashleft": "\u21E0", "/arrowdashright": "\u21E2", "/arrowdashup": "\u21E1", "/arrowdblboth": "\u21D4", "/arrowdbldown": "\u21D3", "/arrowdblleft": "\u21D0", "/arrowdblright": "\u21D2", "/arrowdblup": "\u21D1", "/arrowdown": "\u2193", "/arrowdowndashed": "\u21E3", "/arrowdownfrombar": "\u21A7", "/arrowdownleft": "\u2199", "/arrowdownright": "\u2198", "/arrowdowntwoheaded": "\u21A1", "/arrowdownwhite": "\u21E9", "/arrowdownzigzag": "\u21AF", "/arrowheaddown": "\u2304", "/arrowheaddownlowmod": "\u02EF", "/arrowheaddownmod": "\u02C5", "/arrowheadleftlowmod": "\u02F1", "/arrowheadleftmod": "\u02C2", "/arrowheadrightlowmod": "\u02F2", "/arrowheadrightmod": "\u02C3", "/arrowheadtwobarsuphorizontal": "\u2324", "/arrowheadup": "\u2303", "/arrowheaduplowmod": "\u02F0", "/arrowheadupmod": "\u02C4", "/arrowhorizex": "\uF8E7", "/arrowleft": "\u2190", "/arrowleftdashed": "\u21E0", "/arrowleftdbl": "\u21D0", "/arrowleftdblstroke": "\u21CD", "/arrowleftdowncorner": "\u21B5", "/arrowleftdowntip": "\u21B2", "/arrowleftfrombar": "\u21A4", "/arrowlefthook": "\u21A9", "/arrowleftloop": "\u21AB", "/arrowleftlowmod": "\u02FF", "/arrowleftoverright": "\u21C6", "/arrowleftoverrighttobar": "\u21B9", "/arrowleftright": "\u2194", "/arrowleftrightstroke": "\u21AE", "/arrowleftrightwave": "\u21AD", "/arrowleftsquiggle": "\u21DC", "/arrowleftstroke": "\u219A", "/arrowlefttail": "\u21A2", "/arrowlefttobar": "\u21E4", "/arrowlefttwoheaded": "\u219E", "/arrowleftuptip": "\u21B0", "/arrowleftwave": "\u219C", "/arrowleftwhite": "\u21E6", "/arrowlongNWtobar": "\u21B8", "/arrowright": "\u2192", "/arrowrightdashed": "\u21E2", "/arrowrightdblstroke": "\u21CF", "/arrowrightdowncorner": "\u21B4", "/arrowrightdowntip": "\u21B3", "/arrowrightfrombar": "\u21A6", "/arrowrightheavy": "\u279E", "/arrowrighthook": "\u21AA", "/arrowrightloop": "\u21AC", "/arrowrightoverleft": "\u21C4", "/arrowrightsmallcircle": "\u21F4", "/arrowrightsquiggle": "\u21DD", "/arrowrightstroke": "\u219B", "/arrowrighttail": "\u21A3", "/arrowrighttobar": "\u21E5", "/arrowrighttwoheaded": "\u21A0", "/arrowrightwave": "\u219D", "/arrowrightwhite": "\u21E8", "/arrowspaireddown": "\u21CA", "/arrowspairedleft": "\u21C7", "/arrowspairedright": "\u21C9", "/arrowspairedup": "\u21C8", "/arrowtableft": "\u21E4", "/arrowtabright": "\u21E5", "/arrowup": "\u2191", "/arrowupdashed": "\u21E1", "/arrowupdn": "\u2195", "/arrowupdnbse": "\u21A8", "/arrowupdown": "\u2195", "/arrowupdownbase": "\u21A8", "/arrowupdownwithbase": "\u21A8", "/arrowupfrombar": "\u21A5", "/arrowupleft": "\u2196", "/arrowupleftofdown": "\u21C5", "/arrowupright": "\u2197", "/arrowuprighttip": "\u21B1", "/arrowuptwoheaded": "\u219F", "/arrowupwhite": "\u21E7", "/arrowvertex": "\uF8E6", "/articulatedLorry": "\u1F69B", "/artistPalette": "\u1F3A8", "/aruhuasquare": "\u3301", "/asciicircum": "\u005E", "/asciicircummonospace": "\uFF3E", "/asciitilde": "\u007E", "/asciitildemonospace": "\uFF5E", "/ascript": "\u0251", "/ascriptturned": "\u0252", "/asmallhiragana": "\u3041", "/asmallkatakana": "\u30A1", "/asmallkatakanahalfwidth": "\uFF67", "/asper": "\u1FFE", "/asperacute": "\u1FDE", "/aspergrave": "\u1FDD", "/aspertilde": "\u1FDF", "/assertion": "\u22A6", "/asterisk": "\u002A", "/asteriskaltonearabic": "\u066D", "/asteriskarabic": "\u066D", "/asteriskmath": "\u2217", "/asteriskmonospace": "\uFF0A", "/asterisksmall": "\uFE61", "/asterism": "\u2042", "/astonishedFace": "\u1F632", "/astroke": "\u2C65", "/astronomicaluranus": "\u26E2", "/asuperior": "\uF6E9", "/asympticallyequal": "\u2243", "/asymptoticallyequal": "\u2243", "/at": "\u0040", "/athleticShoe": "\u1F45F", "/atilde": "\u00E3", "/atmonospace": "\uFF20", "/atnachHafukh:hb": "\u05A2", "/atom": "\u269B", "/atsmall": "\uFE6B", "/attentionideographiccircled": "\u329F", "/aturned": "\u0250", "/au": "\uA737", "/aubengali": "\u0994", "/aubergine": "\u1F346", "/aubopomofo": "\u3120", "/audeva": "\u0914", "/aufullwidth": "\u3373", "/augujarati": "\u0A94", "/augurmukhi": "\u0A14", "/augusttelegraph": "\u32C7", "/aulengthmarkbengali": "\u09D7", "/aumatragurmukhi": "\u0A4C", "/austral": "\u20B3", "/automatedTellerMachine": "\u1F3E7", "/automobile": "\u1F697", "/auvowelsignbengali": "\u09CC", "/auvowelsigndeva": "\u094C", "/auvowelsigngujarati": "\u0ACC", "/av": "\uA739", "/avagrahadeva": "\u093D", "/avhorizontalbar": "\uA73B", "/ay": "\uA73D", "/aybarmenian": "\u0561", "/ayin": "\u05E2", "/ayin:hb": "\u05E2", "/ayinalt:hb": "\uFB20", "/ayinaltonehebrew": "\uFB20", "/ayinhebrew": "\u05E2", "/azla:hb": "\u059C", "/b": "\u0062", "/baarerusquare": "\u332D", "/babengali": "\u09AC", "/babyAngel": "\u1F47C", "/babyBottle": "\u1F37C", "/babyChick": "\u1F424", "/backLeftwardsArrowAbove": "\u1F519", "/backOfEnvelope": "\u1F582", "/backslash": "\u005C", "/backslashbarfunc": "\u2340", "/backslashdbl": "\u244A", "/backslashmonospace": "\uFF3C", "/bactrianCamel": "\u1F42B", "/badeva": "\u092C", "/badmintonRacquetAndShuttlecock": "\u1F3F8", "/bagdelimitersshapeleft": "\u27C5", "/bagdelimitersshaperight": "\u27C6", "/baggageClaim": "\u1F6C4", "/bagujarati": "\u0AAC", "/bagurmukhi": "\u0A2C", "/bahiragana": "\u3070", "/bahtthai": "\u0E3F", "/bakatakana": "\u30D0", "/balloon": "\u1F388", "/ballotBoldScriptX": "\u1F5F6", "/ballotBoxBallot": "\u1F5F3", "/ballotBoxBoldCheck": "\u1F5F9", "/ballotBoxBoldScriptX": "\u1F5F7", "/ballotBoxScriptX": "\u1F5F5", "/ballotScriptX": "\u1F5F4", "/bamurda": "\uA9A8", "/banana": "\u1F34C", "/bank": "\u1F3E6", "/banknoteDollarSign": "\u1F4B5", "/banknoteEuroSign": "\u1F4B6", "/banknotePoundSign": "\u1F4B7", "/banknoteYenSign": "\u1F4B4", "/bar": "\u007C", "/barChart": "\u1F4CA", "/barberPole": "\u1F488", "/barfullwidth": "\u3374", "/barmonospace": "\uFF5C", "/barquillverticalleft": "\u2E20", "/barquillverticalright": "\u2E21", "/baseball": "\u26BE", "/basketballAndHoop": "\u1F3C0", "/bath": "\u1F6C0", "/bathtub": "\u1F6C1", "/battery": "\u1F50B", "/bbopomofo": "\u3105", "/bcircle": "\u24D1", "/bdot": "\u1E03", "/bdotaccent": "\u1E03", "/bdotbelow": "\u1E05", "/beachUmbrella": "\u1F3D6", "/beamedAscendingMusicalNotes": "\u1F39C", "/beamedDescendingMusicalNotes": "\u1F39D", "/beamedeighthnotes": "\u266B", "/beamedsixteenthnotes": "\u266C", "/beamfunc": "\u2336", "/bearFace": "\u1F43B", "/beatingHeart": "\u1F493", "/because": "\u2235", "/becyr": "\u0431", "/becyrillic": "\u0431", "/bed": "\u1F6CF", "/beeh": "\u067B", "/beeh.fina": "\uFB53", "/beeh.init": "\uFB54", "/beeh.isol": "\uFB52", "/beeh.medi": "\uFB55", "/beerMug": "\u1F37A", "/beetasquare": "\u333C", "/beh": "\u0628", "/beh.fina": "\uFE90", "/beh.init": "\uFE91", "/beh.init_alefmaksura.fina": "\uFC09", "/beh.init_hah.fina": "\uFC06", "/beh.init_hah.medi": "\uFC9D", "/beh.init_heh.medi": "\uFCA0", "/beh.init_jeem.fina": "\uFC05", "/beh.init_jeem.medi": "\uFC9C", "/beh.init_khah.fina": "\uFC07", "/beh.init_khah.medi": "\uFC9E", "/beh.init_meem.fina": "\uFC08", "/beh.init_meem.medi": "\uFC9F", "/beh.init_yeh.fina": "\uFC0A", "/beh.isol": "\uFE8F", "/beh.medi": "\uFE92", "/beh.medi_alefmaksura.fina": "\uFC6E", "/beh.medi_hah.medi_yeh.fina": "\uFDC2", "/beh.medi_heh.medi": "\uFCE2", "/beh.medi_khah.medi_yeh.fina": "\uFD9E", "/beh.medi_meem.fina": "\uFC6C", "/beh.medi_meem.medi": "\uFCE1", "/beh.medi_noon.fina": "\uFC6D", "/beh.medi_reh.fina": "\uFC6A", "/beh.medi_yeh.fina": "\uFC6F", "/beh.medi_zain.fina": "\uFC6B", "/behDotBelowThreeDotsAbove": "\u0751", "/behInvertedSmallVBelow": "\u0755", "/behSmallV": "\u0756", "/behThreeDotsHorizontallyBelow": "\u0750", "/behThreeDotsUpBelow": "\u0752", "/behThreeDotsUpBelowTwoDotsAbove": "\u0753", "/behTwoDotsBelowDotAbove": "\u0754", "/beharabic": "\u0628", "/beheh": "\u0680", "/beheh.fina": "\uFB5B", "/beheh.init": "\uFB5C", "/beheh.isol": "\uFB5A", "/beheh.medi": "\uFB5D", "/behfinalarabic": "\uFE90", "/behinitialarabic": "\uFE91", "/behiragana": "\u3079", "/behmedialarabic": "\uFE92", "/behmeeminitialarabic": "\uFC9F", "/behmeemisolatedarabic": "\uFC08", "/behnoonfinalarabic": "\uFC6D", "/bekatakana": "\u30D9", "/bellCancellationStroke": "\u1F515", "/bellhopBell": "\u1F6CE", "/beltbuckle": "\u2444", "/benarmenian": "\u0562", "/beng:a": "\u0985", "/beng:aa": "\u0986", "/beng:aasign": "\u09BE", "/beng:abbreviationsign": "\u09FD", "/beng:ai": "\u0990", "/beng:aisign": "\u09C8", "/beng:anji": "\u0980", "/beng:anusvara": "\u0982", "/beng:au": "\u0994", "/beng:aulengthmark": "\u09D7", "/beng:ausign": "\u09CC", "/beng:avagraha": "\u09BD", "/beng:ba": "\u09AC", "/beng:bha": "\u09AD", "/beng:ca": "\u099A", "/beng:candrabindu": "\u0981", "/beng:cha": "\u099B", "/beng:currencyoneless": "\u09F8", "/beng:da": "\u09A6", "/beng:dda": "\u09A1", "/beng:ddha": "\u09A2", "/beng:dha": "\u09A7", "/beng:e": "\u098F", "/beng:eight": "\u09EE", "/beng:esign": "\u09C7", "/beng:five": "\u09EB", "/beng:four": "\u09EA", "/beng:fourcurrencynumerator": "\u09F7", "/beng:ga": "\u0997", "/beng:gandamark": "\u09FB", "/beng:gha": "\u0998", "/beng:ha": "\u09B9", "/beng:i": "\u0987", "/beng:ii": "\u0988", "/beng:iisign": "\u09C0", "/beng:isign": "\u09BF", "/beng:isshar": "\u09FA", "/beng:ja": "\u099C", "/beng:jha": "\u099D", "/beng:ka": "\u0995", "/beng:kha": "\u0996", "/beng:khandata": "\u09CE", "/beng:la": "\u09B2", "/beng:llvocal": "\u09E1", "/beng:llvocalsign": "\u09E3", "/beng:lvocal": "\u098C", "/beng:lvocalsign": "\u09E2", "/beng:ma": "\u09AE", "/beng:na": "\u09A8", "/beng:nga": "\u0999", "/beng:nine": "\u09EF", "/beng:nna": "\u09A3", "/beng:nukta": "\u09BC", "/beng:nya": "\u099E", "/beng:o": "\u0993", "/beng:one": "\u09E7", "/beng:onecurrencynumerator": "\u09F4", "/beng:osign": "\u09CB", "/beng:pa": "\u09AA", "/beng:pha": "\u09AB", "/beng:ra": "\u09B0", "/beng:ralowdiagonal": "\u09F1", "/beng:ramiddiagonal": "\u09F0", "/beng:rha": "\u09DD", "/beng:rra": "\u09DC", "/beng:rrvocal": "\u09E0", "/beng:rrvocalsign": "\u09C4", "/beng:rupee": "\u09F3", "/beng:rupeemark": "\u09F2", "/beng:rvocal": "\u098B", "/beng:rvocalsign": "\u09C3", "/beng:sa": "\u09B8", "/beng:seven": "\u09ED", "/beng:sha": "\u09B6", "/beng:six": "\u09EC", "/beng:sixteencurrencydenominator": "\u09F9", "/beng:ssa": "\u09B7", "/beng:ta": "\u09A4", "/beng:tha": "\u09A5", "/beng:three": "\u09E9", "/beng:threecurrencynumerator": "\u09F6", "/beng:tta": "\u099F", "/beng:ttha": "\u09A0", "/beng:two": "\u09E8", "/beng:twocurrencynumerator": "\u09F5", "/beng:u": "\u0989", "/beng:usign": "\u09C1", "/beng:uu": "\u098A", "/beng:uusign": "\u09C2", "/beng:vedicanusvara": "\u09FC", "/beng:virama": "\u09CD", "/beng:visarga": "\u0983", "/beng:ya": "\u09AF", "/beng:yya": "\u09DF", "/beng:zero": "\u09E6", "/bentoBox": "\u1F371", "/benzenering": "\u232C", "/benzeneringcircle": "\u23E3", "/bet": "\u05D1", "/bet:hb": "\u05D1", "/beta": "\u03B2", "/betasymbol": "\u03D0", "/betasymbolgreek": "\u03D0", "/betdagesh": "\uFB31", "/betdageshhebrew": "\uFB31", "/bethebrew": "\u05D1", "/betrafehebrew": "\uFB4C", "/between": "\u226C", "/betwithdagesh:hb": "\uFB31", "/betwithrafe:hb": "\uFB4C", "/bflourish": "\uA797", "/bhabengali": "\u09AD", "/bhadeva": "\u092D", "/bhagujarati": "\u0AAD", "/bhagurmukhi": "\u0A2D", "/bhook": "\u0253", "/bicycle": "\u1F6B2", "/bicyclist": "\u1F6B4", "/bihiragana": "\u3073", "/bikatakana": "\u30D3", "/bikini": "\u1F459", "/bilabialclick": "\u0298", "/billiards": "\u1F3B1", "/bindigurmukhi": "\u0A02", "/biohazard": "\u2623", "/bird": "\u1F426", "/birthdayCake": "\u1F382", "/birusquare": "\u3331", "/bishopblack": "\u265D", "/bishopwhite": "\u2657", "/bitcoin": "\u20BF", "/blackDownPointingBackhandIndex": "\u1F5A3", "/blackDroplet": "\u1F322", "/blackFolder": "\u1F5BF", "/blackHardShellFloppyDisk": "\u1F5AA", "/blackHeart": "\u1F5A4", "/blackLeftPointingBackhandIndex": "\u1F59C", "/blackPennant": "\u1F3F2", "/blackPushpin": "\u1F588", "/blackRightPointingBackhandIndex": "\u1F59D", "/blackRosette": "\u1F3F6", "/blackSkullAndCrossbones": "\u1F571", "/blackSquareButton": "\u1F532", "/blackTouchtoneTelephone": "\u1F57F", "/blackUpPointingBackhandIndex": "\u1F5A2", "/blackcircle": "\u25CF", "/blackcircleforrecord": "\u23FA", "/blackdiamond": "\u25C6", "/blackdownpointingtriangle": "\u25BC", "/blackforstopsquare": "\u23F9", "/blackleftpointingpointer": "\u25C4", "/blackleftpointingtriangle": "\u25C0", "/blacklenticularbracketleft": "\u3010", "/blacklenticularbracketleftvertical": "\uFE3B", "/blacklenticularbracketright": "\u3011", "/blacklenticularbracketrightvertical": "\uFE3C", "/blacklowerlefttriangle": "\u25E3", "/blacklowerrighttriangle": "\u25E2", "/blackmediumpointingtriangledown": "\u23F7", "/blackmediumpointingtriangleleft": "\u23F4", "/blackmediumpointingtriangleright": "\u23F5", "/blackmediumpointingtriangleup": "\u23F6", "/blackpointingdoubletrianglebarverticalleft": "\u23EE", "/blackpointingdoubletrianglebarverticalright": "\u23ED", "/blackpointingdoubletriangledown": "\u23EC", "/blackpointingdoubletriangleleft": "\u23EA", "/blackpointingdoubletriangleright": "\u23E9", "/blackpointingdoubletriangleup": "\u23EB", "/blackpointingtriangledoublebarverticalright": "\u23EF", "/blackrectangle": "\u25AC", "/blackrightpointingpointer": "\u25BA", "/blackrightpointingtriangle": "\u25B6", "/blacksmallsquare": "\u25AA", "/blacksmilingface": "\u263B", "/blacksquare": "\u25A0", "/blackstar": "\u2605", "/blackupperlefttriangle": "\u25E4", "/blackupperrighttriangle": "\u25E5", "/blackuppointingsmalltriangle": "\u25B4", "/blackuppointingtriangle": "\u25B2", "/blackwardsbulletleft": "\u204C", "/blackwardsbulletright": "\u204D", "/blank": "\u2423", "/blinebelow": "\u1E07", "/block": "\u2588", "/blossom": "\u1F33C", "/blowfish": "\u1F421", "/blueBook": "\u1F4D8", "/blueHeart": "\u1F499", "/bmonospace": "\uFF42", "/boar": "\u1F417", "/board": "\u2328", "/bobaimaithai": "\u0E1A", "/bohiragana": "\u307C", "/bokatakana": "\u30DC", "/bomb": "\u1F4A3", "/book": "\u1F56E", "/bookmark": "\u1F516", "/bookmarkTabs": "\u1F4D1", "/books": "\u1F4DA", "/bopo:a": "\u311A", "/bopo:ai": "\u311E", "/bopo:an": "\u3122", "/bopo:ang": "\u3124", "/bopo:au": "\u3120", "/bopo:b": "\u3105", "/bopo:c": "\u3118", "/bopo:ch": "\u3114", "/bopo:d": "\u3109", "/bopo:e": "\u311C", "/bopo:eh": "\u311D", "/bopo:ei": "\u311F", "/bopo:en": "\u3123", "/bopo:eng": "\u3125", "/bopo:er": "\u3126", "/bopo:f": "\u3108", "/bopo:g": "\u310D", "/bopo:gn": "\u312C", "/bopo:h": "\u310F", "/bopo:i": "\u3127", "/bopo:ih": "\u312D", "/bopo:iu": "\u3129", "/bopo:j": "\u3110", "/bopo:k": "\u310E", "/bopo:l": "\u310C", "/bopo:m": "\u3107", "/bopo:n": "\u310B", "/bopo:ng": "\u312B", "/bopo:o": "\u311B", "/bopo:ou": "\u3121", "/bopo:owithdotabove": "\u312E", "/bopo:p": "\u3106", "/bopo:q": "\u3111", "/bopo:r": "\u3116", "/bopo:s": "\u3119", "/bopo:sh": "\u3115", "/bopo:t": "\u310A", "/bopo:u": "\u3128", "/bopo:v": "\u312A", "/bopo:x": "\u3112", "/bopo:z": "\u3117", "/bopo:zh": "\u3113", "/borutosquare": "\u333E", "/bottlePoppingCork": "\u1F37E", "/bouquet": "\u1F490", "/bouquetOfFlowers": "\u1F395", "/bowAndArrow": "\u1F3F9", "/bowlOfHygieia": "\u1F54F", "/bowling": "\u1F3B3", "/boxlineverticalleft": "\u23B8", "/boxlineverticalright": "\u23B9", "/boy": "\u1F466", "/boys": "\u1F6C9", "/bparen": "\u249D", "/bparenthesized": "\u249D", "/bqfullwidth": "\u33C3", "/bqsquare": "\u33C3", "/braceex": "\uF8F4", "/braceleft": "\u007B", "/braceleftbt": "\uF8F3", "/braceleftmid": "\uF8F2", "/braceleftmonospace": "\uFF5B", "/braceleftsmall": "\uFE5B", "/bracelefttp": "\uF8F1", "/braceleftvertical": "\uFE37", "/braceright": "\u007D", "/bracerightbt": "\uF8FE", "/bracerightmid": "\uF8FD", "/bracerightmonospace": "\uFF5D", "/bracerightsmall": "\uFE5C", "/bracerighttp": "\uF8FC", "/bracerightvertical": "\uFE38", "/bracketangledblleft": "\u27EA", "/bracketangledblright": "\u27EB", "/bracketangleleft": "\u27E8", "/bracketangleright": "\u27E9", "/bracketbottomcurly": "\u23DF", "/bracketbottomsquare": "\u23B5", "/bracketcornerupleftsquare": "\u23A1", "/bracketcorneruprightsquare": "\u23A4", "/bracketdottedsubstitutionleft": "\u2E04", "/bracketdottedsubstitutionright": "\u2E05", "/bracketextensioncurly": "\u23AA", "/bracketextensionleftsquare": "\u23A2", "/bracketextensionrightsquare": "\u23A5", "/brackethalfbottomleft": "\u2E24", "/brackethalfbottomright": "\u2E25", "/brackethalftopleft": "\u2E22", "/brackethalftopright": "\u2E23", "/brackethookupleftcurly": "\u23A7", "/brackethookuprightcurly": "\u23AB", "/bracketleft": "\u005B", "/bracketleftbt": "\uF8F0", "/bracketleftex": "\uF8EF", "/bracketleftmonospace": "\uFF3B", "/bracketleftsquarequill": "\u2045", "/bracketlefttp": "\uF8EE", "/bracketlowercornerleftsquare": "\u23A3", "/bracketlowercornerrightsquare": "\u23A6", "/bracketlowerhookleftcurly": "\u23A9", "/bracketlowerhookrightcurly": "\u23AD", "/bracketmiddlepieceleftcurly": "\u23A8", "/bracketmiddlepiecerightcurly": "\u23AC", "/bracketoverbrackettopbottomsquare": "\u23B6", "/bracketparaphraselowleft": "\u2E1C", "/bracketparaphraselowright": "\u2E1D", "/bracketraisedleft": "\u2E0C", "/bracketraisedright": "\u2E0D", "/bracketright": "\u005D", "/bracketrightbt": "\uF8FB", "/bracketrightex": "\uF8FA", "/bracketrightmonospace": "\uFF3D", "/bracketrightsquarequill": "\u2046", "/bracketrighttp": "\uF8F9", "/bracketsectionupleftlowerrightcurly": "\u23B0", "/bracketsectionuprightlowerleftcurly": "\u23B1", "/bracketshellbottom": "\u23E1", "/bracketshelltop": "\u23E0", "/bracketshellwhiteleft": "\u27EC", "/bracketshellwhiteright": "\u27ED", "/bracketsubstitutionleft": "\u2E02", "/bracketsubstitutionright": "\u2E03", "/brackettopcurly": "\u23DE", "/brackettopsquare": "\u23B4", "/brackettranspositionleft": "\u2E09", "/brackettranspositionright": "\u2E0A", "/bracketwhitesquareleft": "\u27E6", "/bracketwhitesquareright": "\u27E7", "/branchbankidentification": "\u2446", "/bread": "\u1F35E", "/breve": "\u02D8", "/brevebelowcmb": "\u032E", "/brevecmb": "\u0306", "/breveinvertedbelowcmb": "\u032F", "/breveinvertedcmb": "\u0311", "/breveinverteddoublecmb": "\u0361", "/brevemetrical": "\u23D1", "/brideVeil": "\u1F470", "/bridgeAtNight": "\u1F309", "/bridgebelowcmb": "\u032A", "/bridgeinvertedbelowcmb": "\u033A", "/briefcase": "\u1F4BC", "/brll:blank": "\u2800", "/brokenHeart": "\u1F494", "/brokenbar": "\u00A6", "/brokencirclenorthwestarrow": "\u238B", "/bstroke": "\u0180", "/bsuperior": "\uF6EA", "/btopbar": "\u0183", "/bug": "\u1F41B", "/buhiragana": "\u3076", "/buildingConstruction": "\u1F3D7", "/bukatakana": "\u30D6", "/bullet": "\u2022", "/bulletinverse": "\u25D8", "/bulletoperator": "\u2219", "/bullhorn": "\u1F56B", "/bullhornSoundWaves": "\u1F56C", "/bullseye": "\u25CE", "/burrito": "\u1F32F", "/bus": "\u1F68C", "/busStop": "\u1F68F", "/bussyerusquare": "\u3334", "/bustInSilhouette": "\u1F464", "/bustsInSilhouette": "\u1F465", "/c": "\u0063", "/caarmenian": "\u056E", "/cabengali": "\u099A", "/cactus": "\u1F335", "/cacute": "\u0107", "/cadauna": "\u2106", "/cadeva": "\u091A", "/caduceus": "\u2624", "/cagujarati": "\u0A9A", "/cagurmukhi": "\u0A1A", "/cakraconsonant": "\uA9BF", "/calendar": "\u1F4C5", "/calfullwidth": "\u3388", "/callideographicparen": "\u323A", "/calsquare": "\u3388", "/camera": "\u1F4F7", "/cameraFlash": "\u1F4F8", "/camping": "\u1F3D5", "/camurda": "\uA996", "/cancellationX": "\u1F5D9", "/cancer": "\u264B", "/candle": "\u1F56F", "/candrabindubengali": "\u0981", "/candrabinducmb": "\u0310", "/candrabindudeva": "\u0901", "/candrabindugujarati": "\u0A81", "/candy": "\u1F36C", "/canoe": "\u1F6F6", "/capitulum": "\u2E3F", "/capricorn": "\u2651", "/capslock": "\u21EA", "/cardFileBox": "\u1F5C3", "/cardIndex": "\u1F4C7", "/cardIndexDividers": "\u1F5C2", "/careof": "\u2105", "/caret": "\u2038", "/caretinsertionpoint": "\u2041", "/carettildedownfunc": "\u2371", "/carettildeupfunc": "\u2372", "/caron": "\u02C7", "/caronbelowcmb": "\u032C", "/caroncmb": "\u030C", "/carouselHorse": "\u1F3A0", "/carpStreamer": "\u1F38F", "/carriagereturn": "\u21B5", "/carsliding": "\u26D0", "/castle": "\u26EB", "/cat": "\u1F408", "/catFace": "\u1F431", "/catFaceWithTearsOfJoy": "\u1F639", "/catFaceWithWrySmile": "\u1F63C", "/caution": "\u2621", "/cbar": "\uA793", "/cbopomofo": "\u3118", "/ccaron": "\u010D", "/ccedilla": "\u00E7", "/ccedillaacute": "\u1E09", "/ccfullwidth": "\u33C4", "/ccircle": "\u24D2", "/ccircumflex": "\u0109", "/ccurl": "\u0255", "/cdfullwidth": "\u33C5", "/cdot": "\u010B", "/cdotaccent": "\u010B", "/cdotreversed": "\uA73F", "/cdsquare": "\u33C5", "/cecak": "\uA981", "/cecaktelu": "\uA9B3", "/cedi": "\u20B5", "/cedilla": "\u00B8", "/cedillacmb": "\u0327", "/ceilingleft": "\u2308", "/ceilingright": "\u2309", "/celticCross": "\u1F548", "/cent": "\u00A2", "/centigrade": "\u2103", "/centinferior": "\uF6DF", "/centmonospace": "\uFFE0", "/centoldstyle": "\uF7A2", "/centreddotwhitediamond": "\u27D0", "/centreideographiccircled": "\u32A5", "/centreline": "\u2104", "/centrelineverticalsquarewhite": "\u2385", "/centsuperior": "\uF6E0", "/ceres": "\u26B3", "/chaarmenian": "\u0579", "/chabengali": "\u099B", "/chadeva": "\u091B", "/chagujarati": "\u0A9B", "/chagurmukhi": "\u0A1B", "/chains": "\u26D3", "/chair": "\u2441", "/chamkocircle": "\u327C", "/charactertie": "\u2040", "/chartDownwardsTrend": "\u1F4C9", "/chartUpwardsTrend": "\u1F4C8", "/chartUpwardsTrendAndYenSign": "\u1F4B9", "/chbopomofo": "\u3114", "/cheabkhasiancyrillic": "\u04BD", "/cheabkhcyr": "\u04BD", "/cheabkhtailcyr": "\u04BF", "/checkbox": "\u2610", "/checkboxchecked": "\u2611", "/checkboxx": "\u2612", "/checkmark": "\u2713", "/checyr": "\u0447", "/checyrillic": "\u0447", "/chedescenderabkhasiancyrillic": "\u04BF", "/chedescendercyrillic": "\u04B7", "/chedieresiscyr": "\u04F5", "/chedieresiscyrillic": "\u04F5", "/cheeringMegaphone": "\u1F4E3", "/cheharmenian": "\u0573", "/chekhakascyr": "\u04CC", "/chekhakassiancyrillic": "\u04CC", "/chequeredFlag": "\u1F3C1", "/cherries": "\u1F352", "/cherryBlossom": "\u1F338", "/chestnut": "\u1F330", "/chetailcyr": "\u04B7", "/chevertcyr": "\u04B9", "/cheverticalstrokecyrillic": "\u04B9", "/chi": "\u03C7", "/chicken": "\u1F414", "/chieuchacirclekorean": "\u3277", "/chieuchaparenkorean": "\u3217", "/chieuchcirclekorean": "\u3269", "/chieuchkorean": "\u314A", "/chieuchparenkorean": "\u3209", "/childrenCrossing": "\u1F6B8", "/chipmunk": "\u1F43F", "/chirho": "\u2627", "/chiron": "\u26B7", "/chochangthai": "\u0E0A", "/chochanthai": "\u0E08", "/chochingthai": "\u0E09", "/chochoethai": "\u0E0C", "/chocolateBar": "\u1F36B", "/chook": "\u0188", "/christmasTree": "\u1F384", "/church": "\u26EA", "/cieucacirclekorean": "\u3276", "/cieucaparenkorean": "\u3216", "/cieuccirclekorean": "\u3268", "/cieuckorean": "\u3148", "/cieucparenkorean": "\u3208", "/cieucuparenkorean": "\u321C", "/cinema": "\u1F3A6", "/circle": "\u25CB", "/circleallbutupperquadrantleftblack": "\u25D5", "/circlebackslashfunc": "\u2349", "/circleblack": "\u25CF", "/circledCrossPommee": "\u1F540", "/circledInformationSource": "\u1F6C8", "/circledasteriskoperator": "\u229B", "/circledbarnotchhorizontal": "\u2389", "/circledcrossinglanes": "\u26D2", "/circleddash": "\u229D", "/circleddivisionslash": "\u2298", "/circleddotoperator": "\u2299", "/circledequals": "\u229C", "/circlediaeresisfunc": "\u2365", "/circledminus": "\u2296", "/circledot": "\u2299", "/circledotrightwhite": "\u2686", "/circledotted": "\u25CC", "/circledringoperator": "\u229A", "/circledtriangledown": "\u238A", "/circlehalfleftblack": "\u25D0", "/circlehalfrightblack": "\u25D1", "/circleinversewhite": "\u25D9", "/circlejotfunc": "\u233E", "/circlelowerhalfblack": "\u25D2", "/circlelowerquadrantleftwhite": "\u25F5", "/circlelowerquadrantrightwhite": "\u25F6", "/circlemultiply": "\u2297", "/circleot": "\u2299", "/circleplus": "\u2295", "/circlepostalmark": "\u3036", "/circlestarfunc": "\u235F", "/circlestilefunc": "\u233D", "/circlestroketwodotsaboveheavy": "\u26E3", "/circletwodotsblackwhite": "\u2689", "/circletwodotswhite": "\u2687", "/circleunderlinefunc": "\u235C", "/circleupperhalfblack": "\u25D3", "/circleupperquadrantleftwhite": "\u25F4", "/circleupperquadrantrightblack": "\u25D4", "/circleupperquadrantrightwhite": "\u25F7", "/circleverticalfill": "\u25CD", "/circlewhite": "\u25CB", "/circlewhitedotrightblack": "\u2688", "/circlewithlefthalfblack": "\u25D0", "/circlewithrighthalfblack": "\u25D1", "/circumflex": "\u02C6", "/circumflexbelowcmb": "\u032D", "/circumflexcmb": "\u0302", "/circumflexlow": "\uA788", "/circusTent": "\u1F3AA", "/cityscape": "\u1F3D9", "/cityscapeAtDusk": "\u1F306", "/cjk:ideographiccomma": "\u3001", "/cjk:tortoiseshellbracketleft": "\u3014", "/cjk:tortoiseshellbracketright": "\u3015", "/clamshellMobilePhone": "\u1F581", "/clapperBoard": "\u1F3AC", "/clappingHandsSign": "\u1F44F", "/classicalBuilding": "\u1F3DB", "/clear": "\u2327", "/clearscreen": "\u239A", "/clickalveolar": "\u01C2", "/clickbilabial": "\u0298", "/clickdental": "\u01C0", "/clicklateral": "\u01C1", "/clickretroflex": "\u01C3", "/clinkingBeerMugs": "\u1F37B", "/clipboard": "\u1F4CB", "/clockFaceEight-thirty": "\u1F563", "/clockFaceEightOclock": "\u1F557", "/clockFaceEleven-thirty": "\u1F566", "/clockFaceElevenOclock": "\u1F55A", "/clockFaceFive-thirty": "\u1F560", "/clockFaceFiveOclock": "\u1F554", "/clockFaceFour-thirty": "\u1F55F", "/clockFaceFourOclock": "\u1F553", "/clockFaceNine-thirty": "\u1F564", "/clockFaceNineOclock": "\u1F558", "/clockFaceOne-thirty": "\u1F55C", "/clockFaceOneOclock": "\u1F550", "/clockFaceSeven-thirty": "\u1F562", "/clockFaceSevenOclock": "\u1F556", "/clockFaceSix-thirty": "\u1F561", "/clockFaceSixOclock": "\u1F555", "/clockFaceTen-thirty": "\u1F565", "/clockFaceTenOclock": "\u1F559", "/clockFaceThree-thirty": "\u1F55E", "/clockFaceThreeOclock": "\u1F552", "/clockFaceTwelve-thirty": "\u1F567", "/clockFaceTwelveOclock": "\u1F55B", "/clockFaceTwo-thirty": "\u1F55D", "/clockFaceTwoOclock": "\u1F551", "/clockwiseDownwardsAndUpwardsOpenCircleArrows": "\u1F503", "/clockwiseRightAndLeftSemicircleArrows": "\u1F5D8", "/clockwiseRightwardsAndLeftwardsOpenCircleArrows": "\u1F501", "/clockwiseRightwardsAndLeftwardsOpenCircleArrowsCircledOneOverlay": "\u1F502", "/closedBook": "\u1F4D5", "/closedLockKey": "\u1F510", "/closedMailboxLoweredFlag": "\u1F4EA", "/closedMailboxRaisedFlag": "\u1F4EB", "/closedUmbrella": "\u1F302", "/closedentryleft": "\u26DC", "/closeup": "\u2050", "/cloud": "\u2601", "/cloudLightning": "\u1F329", "/cloudRain": "\u1F327", "/cloudSnow": "\u1F328", "/cloudTornado": "\u1F32A", "/clsquare": "\u1F191", "/club": "\u2663", "/clubblack": "\u2663", "/clubsuitblack": "\u2663", "/clubsuitwhite": "\u2667", "/clubwhite": "\u2667", "/cm2fullwidth": "\u33A0", "/cm3fullwidth": "\u33A4", "/cmb:a": "\u0363", "/cmb:aaboveflat": "\u1DD3", "/cmb:aboveogonek": "\u1DCE", "/cmb:acute": "\u0301", "/cmb:acutebelow": "\u0317", "/cmb:acutegraveacute": "\u1DC9", "/cmb:acutemacron": "\u1DC7", "/cmb:acutetone": "\u0341", "/cmb:adieresis": "\u1DF2", "/cmb:ae": "\u1DD4", "/cmb:almostequalabove": "\u034C", "/cmb:almostequaltobelow": "\u1DFD", "/cmb:alpha": "\u1DE7", "/cmb:ao": "\u1DD5", "/cmb:arrowheadleftbelow": "\u0354", "/cmb:arrowheadrightabove": "\u0350", "/cmb:arrowheadrightarrowheadupbelow": "\u0356", "/cmb:arrowheadrightbelow": "\u0355", "/cmb:arrowleftrightbelow": "\u034D", "/cmb:arrowrightdoublebelow": "\u0362", "/cmb:arrowupbelow": "\u034E", "/cmb:asteriskbelow": "\u0359", "/cmb:av": "\u1DD6", "/cmb:b": "\u1DE8", "/cmb:belowbreve": "\u032E", "/cmb:beta": "\u1DE9", "/cmb:breve": "\u0306", "/cmb:brevemacron": "\u1DCB", "/cmb:bridgeabove": "\u0346", "/cmb:bridgebelow": "\u032A", "/cmb:c": "\u0368", "/cmb:candrabindu": "\u0310", "/cmb:caron": "\u030C", "/cmb:caronbelow": "\u032C", "/cmb:ccedilla": "\u1DD7", "/cmb:cedilla": "\u0327", "/cmb:circumflex": "\u0302", "/cmb:circumflexbelow": "\u032D", "/cmb:commaaccentbelow": "\u0326", "/cmb:commaturnedabove": "\u0312", "/cmb:d": "\u0369", "/cmb:dblarchinvertedbelow": "\u032B", "/cmb:dbloverline": "\u033F", "/cmb:dblverticallineabove": "\u030E", "/cmb:dblverticallinebelow": "\u0348", "/cmb:deletionmark": "\u1DFB", "/cmb:dialytikatonos": "\u0344", "/cmb:dieresis": "\u0308", "/cmb:dieresisbelow": "\u0324", "/cmb:dotaboveleft": "\u1DF8", "/cmb:dotaccent": "\u0307", "/cmb:dotbelowcomb": "\u0323", "/cmb:dotrightabove": "\u0358", "/cmb:dottedacute": "\u1DC1", "/cmb:dottedgrave": "\u1DC0", "/cmb:doubleabovecircumflex": "\u1DCD", "/cmb:doublebelowbreve": "\u035C", "/cmb:doublebreve": "\u035D", "/cmb:doubleinvertedbelowbreve": "\u1DFC", "/cmb:doubleringbelow": "\u035A", "/cmb:downtackbelow": "\u031E", "/cmb:e": "\u0364", "/cmb:equalbelow": "\u0347", "/cmb:esh": "\u1DEF", "/cmb:eth": "\u1DD9", "/cmb:f": "\u1DEB", "/cmb:fermata": "\u0352", "/cmb:g": "\u1DDA", "/cmb:graphemejoiner": "\u034F", "/cmb:grave": "\u0300", "/cmb:graveacutegrave": "\u1DC8", "/cmb:gravebelow": "\u0316", "/cmb:gravedouble": "\u030F", "/cmb:gravemacron": "\u1DC5", "/cmb:gravetone": "\u0340", "/cmb:gsmall": "\u1DDB", "/cmb:h": "\u036A", "/cmb:halfleftringabove": "\u0351", "/cmb:halfleftringbelow": "\u031C", "/cmb:halfrightringabove": "\u0357", "/cmb:halfrightringbelow": "\u0339", "/cmb:homotheticabove": "\u034B", "/cmb:hookabove": "\u0309", "/cmb:horn": "\u031B", "/cmb:hungarumlaut": "\u030B", "/cmb:i": "\u0365", "/cmb:insulard": "\u1DD8", "/cmb:invertedbelowbreve": "\u032F", "/cmb:invertedbreve": "\u0311", "/cmb:invertedbridgebelow": "\u033A", "/cmb:inverteddoublebreve": "\u0361", "/cmb:iotasub": "\u0345", "/cmb:isbelow": "\u1DD0", "/cmb:k": "\u1DDC", "/cmb:kavykaaboveleft": "\u1DF7", "/cmb:kavykaaboveright": "\u1DF6", "/cmb:koronis": "\u0343", "/cmb:l": "\u1DDD", "/cmb:leftangleabove": "\u031A", "/cmb:leftanglebelow": "\u0349", "/cmb:leftarrowheadabove": "\u1DFE", "/cmb:lefttackbelow": "\u0318", "/cmb:lineverticalabove": "\u030D", "/cmb:lineverticalbelow": "\u0329", "/cmb:longs": "\u1DE5", "/cmb:lowline": "\u0332", "/cmb:lowlinedouble": "\u0333", "/cmb:lsmall": "\u1DDE", "/cmb:lwithdoublemiddletilde": "\u1DEC", "/cmb:m": "\u036B", "/cmb:macron": "\u0304", "/cmb:macronacute": "\u1DC4", "/cmb:macronbelow": "\u0331", "/cmb:macronbreve": "\u1DCC", "/cmb:macrondouble": "\u035E", "/cmb:macrondoublebelow": "\u035F", "/cmb:macrongrave": "\u1DC6", "/cmb:minusbelow": "\u0320", "/cmb:msmall": "\u1DDF", "/cmb:n": "\u1DE0", "/cmb:nottildeabove": "\u034A", "/cmb:nsmall": "\u1DE1", "/cmb:o": "\u0366", "/cmb:odieresis": "\u1DF3", "/cmb:ogonek": "\u0328", "/cmb:overlaystrokelong": "\u0336", "/cmb:overlaystrokeshort": "\u0335", "/cmb:overline": "\u0305", "/cmb:owithlightcentralizationstroke": "\u1DED", "/cmb:p": "\u1DEE", "/cmb:palatalizedhookbelow": "\u0321", "/cmb:perispomeni": "\u0342", "/cmb:plusbelow": "\u031F", "/cmb:r": "\u036C", "/cmb:rbelow": "\u1DCA", "/cmb:retroflexhookbelow": "\u0322", "/cmb:reversedcommaabove": "\u0314", "/cmb:rightarrowheadanddownarrowheadbelow": "\u1DFF", "/cmb:righttackbelow": "\u0319", "/cmb:ringabove": "\u030A", "/cmb:ringbelow": "\u0325", "/cmb:rrotunda": "\u1DE3", "/cmb:rsmall": "\u1DE2", "/cmb:s": "\u1DE4", "/cmb:schwa": "\u1DEA", "/cmb:seagullbelow": "\u033C", "/cmb:snakebelow": "\u1DC2", "/cmb:soliduslongoverlay": "\u0338", "/cmb:solidusshortoverlay": "\u0337", "/cmb:squarebelow": "\u033B", "/cmb:suspensionmark": "\u1DC3", "/cmb:t": "\u036D", "/cmb:tilde": "\u0303", "/cmb:tildebelow": "\u0330", "/cmb:tildedouble": "\u0360", "/cmb:tildeoverlay": "\u0334", "/cmb:tildevertical": "\u033E", "/cmb:turnedabove": "\u0313", "/cmb:turnedcommaabove": "\u0315", "/cmb:u": "\u0367", "/cmb:udieresis": "\u1DF4", "/cmb:uptackabove": "\u1DF5", "/cmb:uptackbelow": "\u031D", "/cmb:urabove": "\u1DD1", "/cmb:usabove": "\u1DD2", "/cmb:uwithlightcentralizationstroke": "\u1DF0", "/cmb:v": "\u036E", "/cmb:w": "\u1DF1", "/cmb:wideinvertedbridgebelow": "\u1DF9", "/cmb:x": "\u036F", "/cmb:xabove": "\u033D", "/cmb:xbelow": "\u0353", "/cmb:z": "\u1DE6", "/cmb:zigzagabove": "\u035B", "/cmb:zigzagbelow": "\u1DCF", "/cmcubedsquare": "\u33A4", "/cmfullwidth": "\u339D", "/cmonospace": "\uFF43", "/cmsquaredsquare": "\u33A0", "/cntr:acknowledge": "\u2406", "/cntr:backspace": "\u2408", "/cntr:bell": "\u2407", "/cntr:blank": "\u2422", "/cntr:cancel": "\u2418", "/cntr:carriagereturn": "\u240D", "/cntr:datalinkescape": "\u2410", "/cntr:delete": "\u2421", "/cntr:deleteformtwo": "\u2425", "/cntr:devicecontrolfour": "\u2414", "/cntr:devicecontrolone": "\u2411", "/cntr:devicecontrolthree": "\u2413", "/cntr:devicecontroltwo": "\u2412", "/cntr:endofmedium": "\u2419", "/cntr:endoftext": "\u2403", "/cntr:endoftransmission": "\u2404", "/cntr:endoftransmissionblock": "\u2417", "/cntr:enquiry": "\u2405", "/cntr:escape": "\u241B", "/cntr:fileseparator": "\u241C", "/cntr:formfeed": "\u240C", "/cntr:groupseparator": "\u241D", "/cntr:horizontaltab": "\u2409", "/cntr:linefeed": "\u240A", "/cntr:negativeacknowledge": "\u2415", "/cntr:newline": "\u2424", "/cntr:null": "\u2400", "/cntr:openbox": "\u2423", "/cntr:recordseparator": "\u241E", "/cntr:shiftin": "\u240F", "/cntr:shiftout": "\u240E", "/cntr:space": "\u2420", "/cntr:startofheading": "\u2401", "/cntr:startoftext": "\u2402", "/cntr:substitute": "\u241A", "/cntr:substituteformtwo": "\u2426", "/cntr:synchronousidle": "\u2416", "/cntr:unitseparator": "\u241F", "/cntr:verticaltab": "\u240B", "/coarmenian": "\u0581", "/cocktailGlass": "\u1F378", "/coffin": "\u26B0", "/cofullwidth": "\u33C7", "/collision": "\u1F4A5", "/colon": "\u003A", "/colonequals": "\u2254", "/colonmod": "\uA789", "/colonmonetary": "\u20A1", "/colonmonospace": "\uFF1A", "/colonraisedmod": "\u02F8", "/colonsign": "\u20A1", "/colonsmall": "\uFE55", "/colontriangularhalfmod": "\u02D1", "/colontriangularmod": "\u02D0", "/comet": "\u2604", "/comma": "\u002C", "/commaabovecmb": "\u0313", "/commaaboverightcmb": "\u0315", "/commaaccent": "\uF6C3", "/commaarabic": "\u060C", "/commaarmenian": "\u055D", "/commabarfunc": "\u236A", "/commainferior": "\uF6E1", "/commamonospace": "\uFF0C", "/commaraised": "\u2E34", "/commareversed": "\u2E41", "/commareversedabovecmb": "\u0314", "/commareversedmod": "\u02BD", "/commasmall": "\uFE50", "/commasuperior": "\uF6E2", "/commaturnedabovecmb": "\u0312", "/commaturnedmod": "\u02BB", "/commercialat": "\uFE6B", "/commercialminussign": "\u2052", "/compass": "\u263C", "/complement": "\u2201", "/composition": "\u2384", "/compression": "\u1F5DC", "/con": "\uA76F", "/confettiBall": "\u1F38A", "/confoundedFace": "\u1F616", "/confusedFace": "\u1F615", "/congratulationideographiccircled": "\u3297", "/congratulationideographicparen": "\u3237", "/congruent": "\u2245", "/conicaltaper": "\u2332", "/conjunction": "\u260C", "/consquareupblack": "\u26FE", "/constructionSign": "\u1F6A7", "/constructionWorker": "\u1F477", "/containsasmembersmall": "\u220D", "/containsasnormalsubgroorequalup": "\u22B5", "/containsasnormalsubgroup": "\u22B3", "/containslonghorizontalstroke": "\u22FA", "/containsoverbar": "\u22FD", "/containsoverbarsmall": "\u22FE", "/containssmallverticalbarhorizontalstroke": "\u22FC", "/containsverticalbarhorizontalstroke": "\u22FB", "/continuousunderline": "\u2381", "/contourintegral": "\u222E", "/control": "\u2303", "/controlACK": "\u0006", "/controlBEL": "\u0007", "/controlBS": "\u0008", "/controlCAN": "\u0018", "/controlCR": "\u000D", "/controlDC1": "\u0011", "/controlDC2": "\u0012", "/controlDC3": "\u0013", "/controlDC4": "\u0014", "/controlDEL": "\u007F", "/controlDLE": "\u0010", "/controlEM": "\u0019", "/controlENQ": "\u0005", "/controlEOT": "\u0004", "/controlESC": "\u001B", "/controlETB": "\u0017", "/controlETX": "\u0003", "/controlFF": "\u000C", "/controlFS": "\u001C", "/controlGS": "\u001D", "/controlHT": "\u0009", "/controlKnobs": "\u1F39B", "/controlLF": "\u000A", "/controlNAK": "\u0015", "/controlRS": "\u001E", "/controlSI": "\u000F", "/controlSO": "\u000E", "/controlSOT": "\u0002", "/controlSTX": "\u0001", "/controlSUB": "\u001A", "/controlSYN": "\u0016", "/controlUS": "\u001F", "/controlVT": "\u000B", "/convavediamondwhite": "\u27E1", "/convenienceStore": "\u1F3EA", "/cookedRice": "\u1F35A", "/cookie": "\u1F36A", "/cooking": "\u1F373", "/coolsquare": "\u1F192", "/coproductarray": "\u2210", "/copyideographiccircled": "\u32A2", "/copyright": "\u00A9", "/copyrightsans": "\uF8E9", "/copyrightserif": "\uF6D9", "/cornerbottomleft": "\u231E", "/cornerbottomright": "\u231F", "/cornerbracketleft": "\u300C", "/cornerbracketlefthalfwidth": "\uFF62", "/cornerbracketleftvertical": "\uFE41", "/cornerbracketright": "\u300D", "/cornerbracketrighthalfwidth": "\uFF63", "/cornerbracketrightvertical": "\uFE42", "/cornerdotupleft": "\u27D4", "/cornertopleft": "\u231C", "/cornertopright": "\u231D", "/coroniseditorial": "\u2E0E", "/corporationsquare": "\u337F", "/correctideographiccircled": "\u32A3", "/corresponds": "\u2258", "/cosquare": "\u33C7", "/couchAndLamp": "\u1F6CB", "/counterbore": "\u2334", "/countersink": "\u2335", "/coupleHeart": "\u1F491", "/coverkgfullwidth": "\u33C6", "/coverkgsquare": "\u33C6", "/cow": "\u1F404", "/cowFace": "\u1F42E", "/cpalatalhook": "\uA794", "/cparen": "\u249E", "/cparenthesized": "\u249E", "/creditCard": "\u1F4B3", "/crescentMoon": "\u1F319", "/creversed": "\u2184", "/cricketBatAndBall": "\u1F3CF", "/crocodile": "\u1F40A", "/cropbottomleft": "\u230D", "/cropbottomright": "\u230C", "/croptopleft": "\u230F", "/croptopright": "\u230E", "/crossPommee": "\u1F542", "/crossPommeeHalf-circleBelow": "\u1F541", "/crossedFlags": "\u1F38C", "/crossedswords": "\u2694", "/crossinglanes": "\u26CC", "/crossmod": "\u02DF", "/crossofjerusalem": "\u2629", "/crossoflorraine": "\u2628", "/crossonshieldblack": "\u26E8", "/crown": "\u1F451", "/crrn:rupee": "\u20A8", "/cruzeiro": "\u20A2", "/cryingCatFace": "\u1F63F", "/cryingFace": "\u1F622", "/crystalBall": "\u1F52E", "/cstretched": "\u0297", "/cstroke": "\u023C", "/cuatrillo": "\uA72D", "/cuatrillocomma": "\uA72F", "/curlyand": "\u22CF", "/curlylogicaland": "\u22CF", "/curlylogicalor": "\u22CE", "/curlyor": "\u22CE", "/currency": "\u00A4", "/currencyExchange": "\u1F4B1", "/curryAndRice": "\u1F35B", "/custard": "\u1F36E", "/customeraccountnumber": "\u2449", "/customs": "\u1F6C3", "/cyclone": "\u1F300", "/cylindricity": "\u232D", "/cyrBreve": "\uF6D1", "/cyrFlex": "\uF6D2", "/cyrbreve": "\uF6D4", "/cyrflex": "\uF6D5", "/d": "\u0064", "/daarmenian": "\u0564", "/daasusquare": "\u3324", "/dabengali": "\u09A6", "/dad": "\u0636", "/dad.fina": "\uFEBE", "/dad.init": "\uFEBF", "/dad.init_alefmaksura.fina": "\uFD07", "/dad.init_hah.fina": "\uFC23", "/dad.init_hah.medi": "\uFCB5", "/dad.init_jeem.fina": "\uFC22", "/dad.init_jeem.medi": "\uFCB4", "/dad.init_khah.fina": "\uFC24", "/dad.init_khah.medi": "\uFCB6", "/dad.init_khah.medi_meem.medi": "\uFD70", "/dad.init_meem.fina": "\uFC25", "/dad.init_meem.medi": "\uFCB7", "/dad.init_reh.fina": "\uFD10", "/dad.init_yeh.fina": "\uFD08", "/dad.isol": "\uFEBD", "/dad.medi": "\uFEC0", "/dad.medi_alefmaksura.fina": "\uFD23", "/dad.medi_hah.medi_alefmaksura.fina": "\uFD6E", "/dad.medi_hah.medi_yeh.fina": "\uFDAB", "/dad.medi_khah.medi_meem.fina": "\uFD6F", "/dad.medi_reh.fina": "\uFD2C", "/dad.medi_yeh.fina": "\uFD24", "/dadarabic": "\u0636", "/daddotbelow": "\u06FB", "/dadeva": "\u0926", "/dadfinalarabic": "\uFEBE", "/dadinitialarabic": "\uFEBF", "/dadmedialarabic": "\uFEC0", "/dafullwidth": "\u3372", "/dagesh": "\u05BC", "/dagesh:hb": "\u05BC", "/dageshhebrew": "\u05BC", "/dagger": "\u2020", "/daggerKnife": "\u1F5E1", "/daggerdbl": "\u2021", "/daggerwithguardleft": "\u2E36", "/daggerwithguardright": "\u2E37", "/dagujarati": "\u0AA6", "/dagurmukhi": "\u0A26", "/dahal": "\u068C", "/dahal.fina": "\uFB85", "/dahal.isol": "\uFB84", "/dahiragana": "\u3060", "/dakatakana": "\u30C0", "/dal": "\u062F", "/dal.fina": "\uFEAA", "/dal.isol": "\uFEA9", "/dalInvertedSmallVBelow": "\u075A", "/dalTwoDotsVerticallyBelowSmallTah": "\u0759", "/dalarabic": "\u062F", "/daldotbelow": "\u068A", "/daldotbelowtahsmall": "\u068B", "/daldownthreedotsabove": "\u068F", "/dalet": "\u05D3", "/dalet:hb": "\u05D3", "/daletdagesh": "\uFB33", "/daletdageshhebrew": "\uFB33", "/dalethatafpatah": "\u05D3", "/dalethatafpatahhebrew": "\u05D3", "/dalethatafsegol": "\u05D3", "/dalethatafsegolhebrew": "\u05D3", "/dalethebrew": "\u05D3", "/dalethiriq": "\u05D3", "/dalethiriqhebrew": "\u05D3", "/daletholam": "\u05D3", "/daletholamhebrew": "\u05D3", "/daletpatah": "\u05D3", "/daletpatahhebrew": "\u05D3", "/daletqamats": "\u05D3", "/daletqamatshebrew": "\u05D3", "/daletqubuts": "\u05D3", "/daletqubutshebrew": "\u05D3", "/daletsegol": "\u05D3", "/daletsegolhebrew": "\u05D3", "/daletsheva": "\u05D3", "/daletshevahebrew": "\u05D3", "/dalettsere": "\u05D3", "/dalettserehebrew": "\u05D3", "/daletwide:hb": "\uFB22", "/daletwithdagesh:hb": "\uFB33", "/dalfinalarabic": "\uFEAA", "/dalfourdotsabove": "\u0690", "/dalinvertedV": "\u06EE", "/dalring": "\u0689", "/damahaprana": "\uA9A3", "/damma": "\u064F", "/dammaIsol": "\uFE78", "/dammaMedi": "\uFE79", "/dammaarabic": "\u064F", "/dammalowarabic": "\u064F", "/dammareversed": "\u065D", "/dammasmall": "\u0619", "/dammatan": "\u064C", "/dammatanIsol": "\uFE72", "/dammatanaltonearabic": "\u064C", "/dammatanarabic": "\u064C", "/dancer": "\u1F483", "/danda": "\u0964", "/dango": "\u1F361", "/darga:hb": "\u05A7", "/dargahebrew": "\u05A7", "/dargalefthebrew": "\u05A7", "/darkShade": "\u2593", "/darkSunglasses": "\u1F576", "/dashwithupturnleft": "\u2E43", "/dasiacmbcyr": "\u0485", "/dasiapneumatacyrilliccmb": "\u0485", "/dateseparator": "\u060D", "/dayeighteentelegraph": "\u33F1", "/dayeighttelegraph": "\u33E7", "/dayeleventelegraph": "\u33EA", "/dayfifteentelegraph": "\u33EE", "/dayfivetelegraph": "\u33E4", "/dayfourteentelegraph": "\u33ED", "/dayfourtelegraph": "\u33E3", "/daynineteentelegraph": "\u33F2", "/dayninetelegraph": "\u33E8", "/dayonetelegraph": "\u33E0", "/dayseventeentelegraph": "\u33F0", "/dayseventelegraph": "\u33E6", "/daysixteentelegraph": "\u33EF", "/daysixtelegraph": "\u33E5", "/daytentelegraph": "\u33E9", "/daythirteentelegraph": "\u33EC", "/daythirtyonetelegraph": "\u33FE", "/daythirtytelegraph": "\u33FD", "/daythreetelegraph": "\u33E2", "/daytwelvetelegraph": "\u33EB", "/daytwentyeighttelegraph": "\u33FB", "/daytwentyfivetelegraph": "\u33F8", "/daytwentyfourtelegraph": "\u33F7", "/daytwentyninetelegraph": "\u33FC", "/daytwentyonetelegraph": "\u33F4", "/daytwentyseventelegraph": "\u33FA", "/daytwentysixtelegraph": "\u33F9", "/daytwentytelegraph": "\u33F3", "/daytwentythreetelegraph": "\u33F6", "/daytwentytwotelegraph": "\u33F5", "/daytwotelegraph": "\u33E1", "/dbdigraph": "\u0238", "/dbfullwidth": "\u33C8", "/dblGrave": "\uF6D3", "/dblanglebracketleft": "\u300A", "/dblanglebracketleftvertical": "\uFE3D", "/dblanglebracketright": "\u300B", "/dblanglebracketrightvertical": "\uFE3E", "/dblarchinvertedbelowcmb": "\u032B", "/dblarrowNE": "\u21D7", "/dblarrowNW": "\u21D6", "/dblarrowSE": "\u21D8", "/dblarrowSW": "\u21D9", "/dblarrowdown": "\u21D3", "/dblarrowleft": "\u21D4", "/dblarrowleftright": "\u21D4", "/dblarrowleftrightstroke": "\u21CE", "/dblarrowleftstroke": "\u21CD", "/dblarrowright": "\u21D2", "/dblarrowrightstroke": "\u21CF", "/dblarrowup": "\u21D1", "/dblarrowupdown": "\u21D5", "/dbldanda": "\u0965", "/dbldnhorz": "\u2566", "/dbldnleft": "\u2557", "/dbldnright": "\u2554", "/dblgrave": "\uF6D6", "/dblgravecmb": "\u030F", "/dblhorz": "\u2550", "/dblintegral": "\u222C", "/dbllowline": "\u2017", "/dbllowlinecmb": "\u0333", "/dbloverlinecmb": "\u033F", "/dblprimemod": "\u02BA", "/dblstrokearrowdown": "\u21DF", "/dblstrokearrowup": "\u21DE", "/dbluphorz": "\u2569", "/dblupleft": "\u255D", "/dblupright": "\u255A", "/dblvert": "\u2551", "/dblverthorz": "\u256C", "/dblverticalbar": "\u2016", "/dblverticallineabovecmb": "\u030E", "/dblvertleft": "\u2563", "/dblvertright": "\u2560", "/dbopomofo": "\u3109", "/dbsquare": "\u33C8", "/dcaron": "\u010F", "/dcedilla": "\u1E11", "/dchecyr": "\u052D", "/dcircle": "\u24D3", "/dcircumflexbelow": "\u1E13", "/dcroat": "\u0111", "/dcurl": "\u0221", "/ddabengali": "\u09A1", "/ddadeva": "\u0921", "/ddagujarati": "\u0AA1", "/ddagurmukhi": "\u0A21", "/ddahal": "\u068D", "/ddahal.fina": "\uFB83", "/ddahal.isol": "\uFB82", "/ddal": "\u0688", "/ddal.fina": "\uFB89", "/ddal.isol": "\uFB88", "/ddalarabic": "\u0688", "/ddalfinalarabic": "\uFB89", "/ddamahaprana": "\uA99E", "/ddblstruckitalic": "\u2146", "/dddhadeva": "\u095C", "/ddhabengali": "\u09A2", "/ddhadeva": "\u0922", "/ddhagujarati": "\u0AA2", "/ddhagurmukhi": "\u0A22", "/ddot": "\u1E0B", "/ddotaccent": "\u1E0B", "/ddotbelow": "\u1E0D", "/decembertelegraph": "\u32CB", "/deciduousTree": "\u1F333", "/decimalexponent": "\u23E8", "/decimalseparatorarabic": "\u066B", "/decimalseparatorpersian": "\u066B", "/decreaseFontSize": "\u1F5DB", "/decyr": "\u0434", "/decyrillic": "\u0434", "/degree": "\u00B0", "/degreecelsius": "\u2103", "/degreefahrenheit": "\u2109", "/dehi:hb": "\u05AD", "/dehihebrew": "\u05AD", "/dehiragana": "\u3067", "/deicoptic": "\u03EF", "/dekatakana": "\u30C7", "/dekomicyr": "\u0501", "/deldiaeresisfunc": "\u2362", "/deleteleft": "\u232B", "/deleteright": "\u2326", "/deliveryTruck": "\u1F69A", "/delstilefunc": "\u2352", "/delta": "\u03B4", "/deltaequal": "\u225C", "/deltastilefunc": "\u234B", "/deltaturned": "\u018D", "/deltaunderlinefunc": "\u2359", "/deltildefunc": "\u236B", "/denominatorminusonenumeratorbengali": "\u09F8", "/dentistrybottomverticalleft": "\u23CC", "/dentistrybottomverticalright": "\u23BF", "/dentistrycircledownhorizontal": "\u23C1", "/dentistrycircleuphorizontal": "\u23C2", "/dentistrycirclevertical": "\u23C0", "/dentistrydownhorizontal": "\u23C9", "/dentistrytopverticalleft": "\u23CB", "/dentistrytopverticalright": "\u23BE", "/dentistrytriangledownhorizontal": "\u23C4", "/dentistrytriangleuphorizontal": "\u23C5", "/dentistrytrianglevertical": "\u23C3", "/dentistryuphorizontal": "\u23CA", "/dentistrywavedownhorizontal": "\u23C7", "/dentistrywaveuphorizontal": "\u23C8", "/dentistrywavevertical": "\u23C6", "/departmentStore": "\u1F3EC", "/derelictHouseBuilding": "\u1F3DA", "/desert": "\u1F3DC", "/desertIsland": "\u1F3DD", "/desisquare": "\u3325", "/desktopComputer": "\u1F5A5", "/desktopWindow": "\u1F5D4", "/deva:a": "\u0905", "/deva:aa": "\u0906", "/deva:aasign": "\u093E", "/deva:abbreviation": "\u0970", "/deva:acandra": "\u0972", "/deva:acute": "\u0954", "/deva:ai": "\u0910", "/deva:aisign": "\u0948", "/deva:anudatta": "\u0952", "/deva:anusvara": "\u0902", "/deva:ashort": "\u0904", "/deva:au": "\u0914", "/deva:ausign": "\u094C", "/deva:avagraha": "\u093D", "/deva:aw": "\u0975", "/deva:awsign": "\u094F", "/deva:ba": "\u092C", "/deva:bba": "\u097F", "/deva:bha": "\u092D", "/deva:ca": "\u091A", "/deva:candrabindu": "\u0901", "/deva:candrabinduinverted": "\u0900", "/deva:cha": "\u091B", "/deva:da": "\u0926", "/deva:danda": "\u0964", "/deva:dbldanda": "\u0965", "/deva:dda": "\u0921", "/deva:ddda": "\u097E", "/deva:dddha": "\u095C", "/deva:ddha": "\u0922", "/deva:dha": "\u0927", "/deva:dothigh": "\u0971", "/deva:e": "\u090F", "/deva:ecandra": "\u090D", "/deva:eight": "\u096E", "/deva:eshort": "\u090E", "/deva:esign": "\u0947", "/deva:esigncandra": "\u0945", "/deva:esignprishthamatra": "\u094E", "/deva:esignshort": "\u0946", "/deva:fa": "\u095E", "/deva:five": "\u096B", "/deva:four": "\u096A", "/deva:ga": "\u0917", "/deva:gga": "\u097B", "/deva:gha": "\u0918", "/deva:ghha": "\u095A", "/deva:glottalstop": "\u097D", "/deva:grave": "\u0953", "/deva:ha": "\u0939", "/deva:i": "\u0907", "/deva:ii": "\u0908", "/deva:iisign": "\u0940", "/deva:isign": "\u093F", "/deva:ja": "\u091C", "/deva:jha": "\u091D", "/deva:jja": "\u097C", "/deva:ka": "\u0915", "/deva:kha": "\u0916", "/deva:khha": "\u0959", "/deva:la": "\u0932", "/deva:lla": "\u0933", "/deva:llla": "\u0934", "/deva:llvocal": "\u0961", "/deva:llvocalsign": "\u0963", "/deva:lvocal": "\u090C", "/deva:lvocalsign": "\u0962", "/deva:ma": "\u092E", "/deva:marwaridda": "\u0978", "/deva:na": "\u0928", "/deva:nga": "\u0919", "/deva:nine": "\u096F", "/deva:nna": "\u0923", "/deva:nnna": "\u0929", "/deva:nukta": "\u093C", "/deva:nya": "\u091E", "/deva:o": "\u0913", "/deva:ocandra": "\u0911", "/deva:oe": "\u0973", "/deva:oesign": "\u093A", "/deva:om": "\u0950", "/deva:one": "\u0967", "/deva:ooe": "\u0974", "/deva:ooesign": "\u093B", "/deva:oshort": "\u0912", "/deva:osign": "\u094B", "/deva:osigncandra": "\u0949", "/deva:osignshort": "\u094A", "/deva:pa": "\u092A", "/deva:pha": "\u092B", "/deva:qa": "\u0958", "/deva:ra": "\u0930", "/deva:rha": "\u095D", "/deva:rra": "\u0931", "/deva:rrvocal": "\u0960", "/deva:rrvocalsign": "\u0944", "/deva:rvocal": "\u090B", "/deva:rvocalsign": "\u0943", "/deva:sa": "\u0938", "/deva:seven": "\u096D", "/deva:sha": "\u0936", "/deva:signelongcandra": "\u0955", "/deva:six": "\u096C", "/deva:ssa": "\u0937", "/deva:ta": "\u0924", "/deva:tha": "\u0925", "/deva:three": "\u0969", "/deva:tta": "\u091F", "/deva:ttha": "\u0920", "/deva:two": "\u0968", "/deva:u": "\u0909", "/deva:udatta": "\u0951", "/deva:ue": "\u0976", "/deva:uesign": "\u0956", "/deva:usign": "\u0941", "/deva:uu": "\u090A", "/deva:uue": "\u0977", "/deva:uuesign": "\u0957", "/deva:uusign": "\u0942", "/deva:va": "\u0935", "/deva:virama": "\u094D", "/deva:visarga": "\u0903", "/deva:ya": "\u092F", "/deva:yaheavy": "\u097A", "/deva:yya": "\u095F", "/deva:za": "\u095B", "/deva:zero": "\u0966", "/deva:zha": "\u0979", "/dezh": "\u02A4", "/dfemaledbl": "\u26A2", "/dhabengali": "\u09A7", "/dhadeva": "\u0927", "/dhagujarati": "\u0AA7", "/dhagurmukhi": "\u0A27", "/dhook": "\u0257", "/diaeresisgreaterfunc": "\u2369", "/dialytikatonos": "\u0385", "/dialytikatonoscmb": "\u0344", "/diametersign": "\u2300", "/diamond": "\u2666", "/diamondShapeADotInside": "\u1F4A0", "/diamondinsquarewhite": "\u26CB", "/diamondoperator": "\u22C4", "/diamondsuitwhite": "\u2662", "/diamondunderlinefunc": "\u235A", "/diamondwhitewithdiamondsmallblack": "\u25C8", "/diefive": "\u2684", "/diefour": "\u2683", "/dieone": "\u2680", "/dieresis": "\u00A8", "/dieresisacute": "\uF6D7", "/dieresisbelowcmb": "\u0324", "/dieresiscmb": "\u0308", "/dieresisgrave": "\uF6D8", "/dieresistilde": "\u1FC1", "/dieresistonos": "\u0385", "/dieselLocomotive": "\u1F6F2", "/diesix": "\u2685", "/diethree": "\u2682", "/dietwo": "\u2681", "/differencebetween": "\u224F", "/digamma": "\u03DD", "/digammapamphylian": "\u0377", "/digramgreateryang": "\u268C", "/digramgreateryin": "\u268F", "/digramlesseryang": "\u268E", "/digramlesseryin": "\u268D", "/dihiragana": "\u3062", "/dikatakana": "\u30C2", "/dimensionorigin": "\u2331", "/dingbatSAns-serifzerocircle": "\u1F10B", "/dingbatSAns-serifzerocircleblack": "\u1F10C", "/dinsular": "\uA77A", "/directHit": "\u1F3AF", "/directcurrentformtwo": "\u2393", "/dirgamurevowel": "\uA9BB", "/disabledcar": "\u26CD", "/disappointedButRelievedFace": "\u1F625", "/disappointedFace": "\u1F61E", "/discontinuousunderline": "\u2382", "/dittomark": "\u3003", "/divide": "\u00F7", "/divides": "\u2223", "/divisionslash": "\u2215", "/divisiontimes": "\u22C7", "/divorce": "\u26AE", "/dizzy": "\u1F4AB", "/dizzyFace": "\u1F635", "/djecyr": "\u0452", "/djecyrillic": "\u0452", "/djekomicyr": "\u0503", "/dkshade": "\u2593", "/dlfullwidth": "\u3397", "/dlinebelow": "\u1E0F", "/dlogicalorsquare": "\u27CF", "/dlogicalsquare": "\u27CE", "/dlsquare": "\u3397", "/dm2fullwidth": "\u3378", "/dm3fullwidth": "\u3379", "/dmacron": "\u0111", "/dmaledbl": "\u26A3", "/dmfullwidth": "\u3377", "/dmonospace": "\uFF44", "/dnblock": "\u2584", "/dndblhorzsng": "\u2565", "/dndblleftsng": "\u2556", "/dndblrightsng": "\u2553", "/dngb:airplane": "\u2708", "/dngb:arrowfeatheredblackNE": "\u27B6", "/dngb:arrowfeatheredblackSE": "\u27B4", "/dngb:arrowfeatheredblackheavyNE": "\u27B9", "/dngb:arrowfeatheredblackheavySE": "\u27B7", "/dngb:arrowheadrightblack": "\u27A4", "/dngb:arrowheadrightthreeDbottomlight": "\u27A3", "/dngb:arrowheadrightthreeDtoplight": "\u27A2", "/dngb:arrowheavyNE": "\u279A", "/dngb:arrowheavySE": "\u2798", "/dngb:arrowrightbacktiltedshadowedwhite": "\u27AB", "/dngb:arrowrightblack": "\u27A1", "/dngb:arrowrightcircledwhiteheavy": "\u27B2", "/dngb:arrowrightcurvedownblackheavy": "\u27A5", "/dngb:arrowrightcurveupblackheavy": "\u27A6", "/dngb:arrowrightfeatheredblack": "\u27B5", "/dngb:arrowrightfeatheredblackheavy": "\u27B8", "/dngb:arrowrightfeatheredwhite": "\u27B3", "/dngb:arrowrightfronttiltedshadowedwhite": "\u27AC", "/dngb:arrowrightheavy": "\u2799", "/dngb:arrowrightleftshadedwhite": "\u27AA", "/dngb:arrowrightoutlinedopen": "\u27BE", "/dngb:arrowrightpointed": "\u279B", "/dngb:arrowrightpointedblackheavy": "\u27A8", "/dngb:arrowrightrightshadedwhite": "\u27A9", "/dngb:arrowrightroundheavy": "\u279C", "/dngb:arrowrightsquatblack": "\u27A7", "/dngb:arrowrighttriangle": "\u279D", "/dngb:arrowrighttriangledashed": "\u279F", "/dngb:arrowrighttriangledashedheavy": "\u27A0", "/dngb:arrowrighttriangleheavy": "\u279E", "/dngb:arrowrightwedge": "\u27BC", "/dngb:arrowrightwedgeheavy": "\u27BD", "/dngb:arrowrightwideheavy": "\u2794", "/dngb:arrowshadowrightlowerwhiteheavy": "\u27AD", "/dngb:arrowshadowrightnotchedlowerwhite": "\u27AF", "/dngb:arrowshadowrightnotchedupperwhite": "\u27B1", "/dngb:arrowshadowrightupperwhiteheavy": "\u27AE", "/dngb:arrowteardropright": "\u27BA", "/dngb:arrowteardroprightheavy": "\u27BB", "/dngb:asteriskballoon": "\u2749", "/dngb:asteriskballoonfour": "\u2723", "/dngb:asteriskballoonheavyfour": "\u2724", "/dngb:asteriskcentreopen": "\u2732", "/dngb:asteriskclubfour": "\u2725", "/dngb:asteriskheavy": "\u2731", "/dngb:asteriskpointedsixteen": "\u273A", "/dngb:asteriskteardrop": "\u273B", "/dngb:asteriskteardropcentreopen": "\u273C", "/dngb:asteriskteardropfour": "\u2722", "/dngb:asteriskteardropheavy": "\u273D", "/dngb:asteriskteardroppinwheelheavy": "\u2743", "/dngb:asteriskteardroppropellereight": "\u274A", "/dngb:asteriskteardroppropellerheavyeight": "\u274B", "/dngb:ballotx": "\u2717", "/dngb:ballotxheavy": "\u2718", "/dngb:bracketleftpointedangleheavyornament": "\u2770", "/dngb:bracketleftpointedanglemediumornament": "\u276C", "/dngb:bracketrightpointedangleheavyornament": "\u2771", "/dngb:bracketrightpointedanglemediumornament": "\u276D", "/dngb:bracketshellleftlightornament": "\u2772", "/dngb:bracketshellrightlightornament": "\u2773", "/dngb:check": "\u2713", "/dngb:checkheavy": "\u2714", "/dngb:checkwhiteheavy": "\u2705", "/dngb:chevronsnowflakeheavy": "\u2746", "/dngb:circleshadowedwhite": "\u274D", "/dngb:commaheavydoubleornament": "\u275E", "/dngb:commaheavydoubleturnedornament": "\u275D", "/dngb:commaheavyornament": "\u275C", "/dngb:commaheavyturnedornament": "\u275B", "/dngb:compasstarpointedblackeight": "\u2737", "/dngb:compasstarpointedblackheavyeight": "\u2738", "/dngb:cross": "\u274C", "/dngb:crosscentreopen": "\u271B", "/dngb:crosscentreopenheavy": "\u271C", "/dngb:curlybracketleftmediumornament": "\u2774", "/dngb:curlybracketrightmediumornament": "\u2775", "/dngb:curlyloop": "\u27B0", "/dngb:curlyloopdouble": "\u27BF", "/dngb:curvedstemparagraphsignornament": "\u2761", "/dngb:diamondminusxblackwhite": "\u2756", "/dngb:divisionsignheavy": "\u2797", "/dngb:eightnegativecircled": "\u277D", "/dngb:eightsanscircled": "\u2787", "/dngb:eightsansnegativecircled": "\u2791", "/dngb:envelope": "\u2709", "/dngb:exclamationheavy": "\u2757", "/dngb:exclamationheavyornament": "\u2762", "/dngb:exclamationwhiteornament": "\u2755", "/dngb:fivenegativecircled": "\u277A", "/dngb:fivesanscircled": "\u2784", "/dngb:fivesansnegativecircled": "\u278E", "/dngb:floralheart": "\u2766", "/dngb:floralheartbulletrotated": "\u2767", "/dngb:floretteblack": "\u273F", "/dngb:floretteoutlinedpetalledblackeight": "\u2741", "/dngb:florettepetalledblackwhitesix": "\u273E", "/dngb:florettewhite": "\u2740", "/dngb:fournegativecircled": "\u2779", "/dngb:foursanscircled": "\u2783", "/dngb:foursansnegativecircled": "\u278D", "/dngb:greekcrossheavy": "\u271A", "/dngb:greekcrossoutlined": "\u2719", "/dngb:heartblackheavy": "\u2764", "/dngb:heartbulletrotatedblackheavy": "\u2765", "/dngb:heartexclamationheavyornament": "\u2763", "/dngb:hvictory": "\u270C", "/dngb:hwriting": "\u270D", "/dngb:latincross": "\u271D", "/dngb:latincrossoutlined": "\u271F", "/dngb:latincrossshadowedwhite": "\u271E", "/dngb:lowcommaheavydoubleornament": "\u2760", "/dngb:lowcommaheavyornament": "\u275F", "/dngb:maltesecross": "\u2720", "/dngb:minussignheavy": "\u2796", "/dngb:multiplicationx": "\u2715", "/dngb:multiplicationxheavy": "\u2716", "/dngb:nibblack": "\u2712", "/dngb:nibwhite": "\u2711", "/dngb:ninenegativecircled": "\u277E", "/dngb:ninesanscircled": "\u2788", "/dngb:ninesansnegativecircled": "\u2792", "/dngb:onenegativecircled": "\u2776", "/dngb:onesanscircled": "\u2780", "/dngb:onesansnegativecircled": "\u278A", "/dngb:parenthesisleftflattenedmediumornament": "\u276A", "/dngb:parenthesisleftmediumornament": "\u2768", "/dngb:parenthesisrightflattenedmediumornament": "\u276B", "/dngb:parenthesisrightmediumornament": "\u2769", "/dngb:pencil": "\u270F", "/dngb:pencillowerright": "\u270E", "/dngb:pencilupperright": "\u2710", "/dngb:plussignheavy": "\u2795", "/dngb:questionblackornament": "\u2753", "/dngb:questionwhiteornament": "\u2754", "/dngb:quotationleftpointedangleheavyornament": "\u276E", "/dngb:quotationrightpointedangleheavyornament": "\u276F", "/dngb:raisedfist": "\u270A", "/dngb:raisedh": "\u270B", "/dngb:safetyscissorsblack": "\u2700", "/dngb:scissorsblack": "\u2702", "/dngb:scissorslowerblade": "\u2703", "/dngb:scissorsupperblade": "\u2701", "/dngb:scissorswhite": "\u2704", "/dngb:sevennegativecircled": "\u277C", "/dngb:sevensanscircled": "\u2786", "/dngb:sevensansnegativecircled": "\u2790", "/dngb:sixnegativecircled": "\u277B", "/dngb:sixsanscircled": "\u2785", "/dngb:sixsansnegativecircled": "\u278F", "/dngb:snowflake": "\u2744", "/dngb:snowflaketight": "\u2745", "/dngb:sparkle": "\u2747", "/dngb:sparkleheavy": "\u2748", "/dngb:sparkles": "\u2728", "/dngb:spokedasteriskeight": "\u2733", "/dngb:squaredcrossnegative": "\u274E", "/dngb:squarelowerrightshadowedwhite": "\u2751", "/dngb:squareshadowlowerrightwhite": "\u274F", "/dngb:squareshadowupperrightwhite": "\u2750", "/dngb:squareupperrightshadowedwhite": "\u2752", "/dngb:starcentreblackwhite": "\u272C", "/dngb:starcentreopenblack": "\u272B", "/dngb:starcentreopenpointedcircledeight": "\u2742", "/dngb:starcircledwhite": "\u272A", "/dngb:starofdavid": "\u2721", "/dngb:staroutlinedblack": "\u272D", "/dngb:staroutlinedblackheavy": "\u272E", "/dngb:staroutlinedstresswhite": "\u2729", "/dngb:starpinwheel": "\u272F", "/dngb:starpointedblackeight": "\u2734", "/dngb:starpointedblackfour": "\u2726", "/dngb:starpointedblacksix": "\u2736", "/dngb:starpointedblacktwelve": "\u2739", "/dngb:starpointedpinwheeleight": "\u2735", "/dngb:starpointedwhitefour": "\u2727", "/dngb:starshadowedwhite": "\u2730", "/dngb:tapedrive": "\u2707", "/dngb:telephonelocationsign": "\u2706", "/dngb:tennegativecircled": "\u277F", "/dngb:tensanscircled": "\u2789", "/dngb:tensansnegativecircled": "\u2793", "/dngb:threenegativecircled": "\u2778", "/dngb:threesanscircled": "\u2782", "/dngb:threesansnegativecircled": "\u278C", "/dngb:twonegativecircled": "\u2777", "/dngb:twosanscircled": "\u2781", "/dngb:twosansnegativecircled": "\u278B", "/dngb:verticalbarheavy": "\u275A", "/dngb:verticalbarlight": "\u2758", "/dngb:verticalbarmedium": "\u2759", "/dnheavyhorzlight": "\u2530", "/dnheavyleftlight": "\u2512", "/dnheavyleftuplight": "\u2527", "/dnheavyrightlight": "\u250E", "/dnheavyrightuplight": "\u251F", "/dnheavyuphorzlight": "\u2541", "/dnlighthorzheavy": "\u252F", "/dnlightleftheavy": "\u2511", "/dnlightleftupheavy": "\u2529", "/dnlightrightheavy": "\u250D", "/dnlightrightupheavy": "\u2521", "/dnlightuphorzheavy": "\u2547", "/dnsnghorzdbl": "\u2564", "/dnsngleftdbl": "\u2555", "/dnsngrightdbl": "\u2552", "/doNotLitter": "\u1F6AF", "/dochadathai": "\u0E0E", "/document": "\u1F5CE", "/documentPicture": "\u1F5BB", "/documentText": "\u1F5B9", "/documentTextAndPicture": "\u1F5BA", "/dodekthai": "\u0E14", "/doesnotcontainasnormalsubgroorequalup": "\u22ED", "/doesnotcontainasnormalsubgroup": "\u22EB", "/doesnotdivide": "\u2224", "/doesnotforce": "\u22AE", "/doesnotprecede": "\u2280", "/doesnotprecedeorequal": "\u22E0", "/doesnotprove": "\u22AC", "/doesnotsucceed": "\u2281", "/doesnotsucceedorequal": "\u22E1", "/dog": "\u1F415", "/dogFace": "\u1F436", "/dohiragana": "\u3069", "/dokatakana": "\u30C9", "/dollar": "\u0024", "/dollarinferior": "\uF6E3", "/dollarmonospace": "\uFF04", "/dollaroldstyle": "\uF724", "/dollarsmall": "\uFE69", "/dollarsuperior": "\uF6E4", "/dolphin": "\u1F42C", "/dominohorizontal_00_00": "\u1F031", "/dominohorizontal_00_01": "\u1F032", "/dominohorizontal_00_02": "\u1F033", "/dominohorizontal_00_03": "\u1F034", "/dominohorizontal_00_04": "\u1F035", "/dominohorizontal_00_05": "\u1F036", "/dominohorizontal_00_06": "\u1F037", "/dominohorizontal_01_00": "\u1F038", "/dominohorizontal_01_01": "\u1F039", "/dominohorizontal_01_02": "\u1F03A", "/dominohorizontal_01_03": "\u1F03B", "/dominohorizontal_01_04": "\u1F03C", "/dominohorizontal_01_05": "\u1F03D", "/dominohorizontal_01_06": "\u1F03E", "/dominohorizontal_02_00": "\u1F03F", "/dominohorizontal_02_01": "\u1F040", "/dominohorizontal_02_02": "\u1F041", "/dominohorizontal_02_03": "\u1F042", "/dominohorizontal_02_04": "\u1F043", "/dominohorizontal_02_05": "\u1F044", "/dominohorizontal_02_06": "\u1F045", "/dominohorizontal_03_00": "\u1F046", "/dominohorizontal_03_01": "\u1F047", "/dominohorizontal_03_02": "\u1F048", "/dominohorizontal_03_03": "\u1F049", "/dominohorizontal_03_04": "\u1F04A", "/dominohorizontal_03_05": "\u1F04B", "/dominohorizontal_03_06": "\u1F04C", "/dominohorizontal_04_00": "\u1F04D", "/dominohorizontal_04_01": "\u1F04E", "/dominohorizontal_04_02": "\u1F04F", "/dominohorizontal_04_03": "\u1F050", "/dominohorizontal_04_04": "\u1F051", "/dominohorizontal_04_05": "\u1F052", "/dominohorizontal_04_06": "\u1F053", "/dominohorizontal_05_00": "\u1F054", "/dominohorizontal_05_01": "\u1F055", "/dominohorizontal_05_02": "\u1F056", "/dominohorizontal_05_03": "\u1F057", "/dominohorizontal_05_04": "\u1F058", "/dominohorizontal_05_05": "\u1F059", "/dominohorizontal_05_06": "\u1F05A", "/dominohorizontal_06_00": "\u1F05B", "/dominohorizontal_06_01": "\u1F05C", "/dominohorizontal_06_02": "\u1F05D", "/dominohorizontal_06_03": "\u1F05E", "/dominohorizontal_06_04": "\u1F05F", "/dominohorizontal_06_05": "\u1F060", "/dominohorizontal_06_06": "\u1F061", "/dominohorizontalback": "\u1F030", "/dominovertical_00_00": "\u1F063", "/dominovertical_00_01": "\u1F064", "/dominovertical_00_02": "\u1F065", "/dominovertical_00_03": "\u1F066", "/dominovertical_00_04": "\u1F067", "/dominovertical_00_05": "\u1F068", "/dominovertical_00_06": "\u1F069", "/dominovertical_01_00": "\u1F06A", "/dominovertical_01_01": "\u1F06B", "/dominovertical_01_02": "\u1F06C", "/dominovertical_01_03": "\u1F06D", "/dominovertical_01_04": "\u1F06E", "/dominovertical_01_05": "\u1F06F", "/dominovertical_01_06": "\u1F070", "/dominovertical_02_00": "\u1F071", "/dominovertical_02_01": "\u1F072", "/dominovertical_02_02": "\u1F073", "/dominovertical_02_03": "\u1F074", "/dominovertical_02_04": "\u1F075", "/dominovertical_02_05": "\u1F076", "/dominovertical_02_06": "\u1F077", "/dominovertical_03_00": "\u1F078", "/dominovertical_03_01": "\u1F079", "/dominovertical_03_02": "\u1F07A", "/dominovertical_03_03": "\u1F07B", "/dominovertical_03_04": "\u1F07C", "/dominovertical_03_05": "\u1F07D", "/dominovertical_03_06": "\u1F07E", "/dominovertical_04_00": "\u1F07F", "/dominovertical_04_01": "\u1F080", "/dominovertical_04_02": "\u1F081", "/dominovertical_04_03": "\u1F082", "/dominovertical_04_04": "\u1F083", "/dominovertical_04_05": "\u1F084", "/dominovertical_04_06": "\u1F085", "/dominovertical_05_00": "\u1F086", "/dominovertical_05_01": "\u1F087", "/dominovertical_05_02": "\u1F088", "/dominovertical_05_03": "\u1F089", "/dominovertical_05_04": "\u1F08A", "/dominovertical_05_05": "\u1F08B", "/dominovertical_05_06": "\u1F08C", "/dominovertical_06_00": "\u1F08D", "/dominovertical_06_01": "\u1F08E", "/dominovertical_06_02": "\u1F08F", "/dominovertical_06_03": "\u1F090", "/dominovertical_06_04": "\u1F091", "/dominovertical_06_05": "\u1F092", "/dominovertical_06_06": "\u1F093", "/dominoverticalback": "\u1F062", "/dong": "\u20AB", "/door": "\u1F6AA", "/dorusquare": "\u3326", "/dot": "\u27D1", "/dotaccent": "\u02D9", "/dotaccentcmb": "\u0307", "/dotbelowcmb": "\u0323", "/dotbelowcomb": "\u0323", "/dotkatakana": "\u30FB", "/dotlessbeh": "\u066E", "/dotlessfeh": "\u06A1", "/dotlessi": "\u0131", "/dotlessj": "\uF6BE", "/dotlessjstroke": "\u025F", "/dotlessjstrokehook": "\u0284", "/dotlesskhahabove": "\u06E1", "/dotlessqaf": "\u066F", "/dotlower:hb": "\u05C5", "/dotmath": "\u22C5", "/dotminus": "\u2238", "/dotplus": "\u2214", "/dotraised": "\u2E33", "/dots1": "\u2801", "/dots12": "\u2803", "/dots123": "\u2807", "/dots1234": "\u280F", "/dots12345": "\u281F", "/dots123456": "\u283F", "/dots1234567": "\u287F", "/dots12345678": "\u28FF", "/dots1234568": "\u28BF", "/dots123457": "\u285F", "/dots1234578": "\u28DF", "/dots123458": "\u289F", "/dots12346": "\u282F", "/dots123467": "\u286F", "/dots1234678": "\u28EF", "/dots123468": "\u28AF", "/dots12347": "\u284F", "/dots123478": "\u28CF", "/dots12348": "\u288F", "/dots1235": "\u2817", "/dots12356": "\u2837", "/dots123567": "\u2877", "/dots1235678": "\u28F7", "/dots123568": "\u28B7", "/dots12357": "\u2857", "/dots123578": "\u28D7", "/dots12358": "\u2897", "/dots1236": "\u2827", "/dots12367": "\u2867", "/dots123678": "\u28E7", "/dots12368": "\u28A7", "/dots1237": "\u2847", "/dots12378": "\u28C7", "/dots1238": "\u2887", "/dots124": "\u280B", "/dots1245": "\u281B", "/dots12456": "\u283B", "/dots124567": "\u287B", "/dots1245678": "\u28FB", "/dots124568": "\u28BB", "/dots12457": "\u285B", "/dots124578": "\u28DB", "/dots12458": "\u289B", "/dots1246": "\u282B", "/dots12467": "\u286B", "/dots124678": "\u28EB", "/dots12468": "\u28AB", "/dots1247": "\u284B", "/dots12478": "\u28CB", "/dots1248": "\u288B", "/dots125": "\u2813", "/dots1256": "\u2833", "/dots12567": "\u2873", "/dots125678": "\u28F3", "/dots12568": "\u28B3", "/dots1257": "\u2853", "/dots12578": "\u28D3", "/dots1258": "\u2893", "/dots126": "\u2823", "/dots1267": "\u2863", "/dots12678": "\u28E3", "/dots1268": "\u28A3", "/dots127": "\u2843", "/dots1278": "\u28C3", "/dots128": "\u2883", "/dots13": "\u2805", "/dots134": "\u280D", "/dots1345": "\u281D", "/dots13456": "\u283D", "/dots134567": "\u287D", "/dots1345678": "\u28FD", "/dots134568": "\u28BD", "/dots13457": "\u285D", "/dots134578": "\u28DD", "/dots13458": "\u289D", "/dots1346": "\u282D", "/dots13467": "\u286D", "/dots134678": "\u28ED", "/dots13468": "\u28AD", "/dots1347": "\u284D", "/dots13478": "\u28CD", "/dots1348": "\u288D", "/dots135": "\u2815", "/dots1356": "\u2835", "/dots13567": "\u2875", "/dots135678": "\u28F5", "/dots13568": "\u28B5", "/dots1357": "\u2855", "/dots13578": "\u28D5", "/dots1358": "\u2895", "/dots136": "\u2825", "/dots1367": "\u2865", "/dots13678": "\u28E5", "/dots1368": "\u28A5", "/dots137": "\u2845", "/dots1378": "\u28C5", "/dots138": "\u2885", "/dots14": "\u2809", "/dots145": "\u2819", "/dots1456": "\u2839", "/dots14567": "\u2879", "/dots145678": "\u28F9", "/dots14568": "\u28B9", "/dots1457": "\u2859", "/dots14578": "\u28D9", "/dots1458": "\u2899", "/dots146": "\u2829", "/dots1467": "\u2869", "/dots14678": "\u28E9", "/dots1468": "\u28A9", "/dots147": "\u2849", "/dots1478": "\u28C9", "/dots148": "\u2889", "/dots15": "\u2811", "/dots156": "\u2831", "/dots1567": "\u2871", "/dots15678": "\u28F1", "/dots1568": "\u28B1", "/dots157": "\u2851", "/dots1578": "\u28D1", "/dots158": "\u2891", "/dots16": "\u2821", "/dots167": "\u2861", "/dots1678": "\u28E1", "/dots168": "\u28A1", "/dots17": "\u2841", "/dots178": "\u28C1", "/dots18": "\u2881", "/dots2": "\u2802", "/dots23": "\u2806", "/dots234": "\u280E", "/dots2345": "\u281E", "/dots23456": "\u283E", "/dots234567": "\u287E", "/dots2345678": "\u28FE", "/dots234568": "\u28BE", "/dots23457": "\u285E", "/dots234578": "\u28DE", "/dots23458": "\u289E", "/dots2346": "\u282E", "/dots23467": "\u286E", "/dots234678": "\u28EE", "/dots23468": "\u28AE", "/dots2347": "\u284E", "/dots23478": "\u28CE", "/dots2348": "\u288E", "/dots235": "\u2816", "/dots2356": "\u2836", "/dots23567": "\u2876", "/dots235678": "\u28F6", "/dots23568": "\u28B6", "/dots2357": "\u2856", "/dots23578": "\u28D6", "/dots2358": "\u2896", "/dots236": "\u2826", "/dots2367": "\u2866", "/dots23678": "\u28E6", "/dots2368": "\u28A6", "/dots237": "\u2846", "/dots2378": "\u28C6", "/dots238": "\u2886", "/dots24": "\u280A", "/dots245": "\u281A", "/dots2456": "\u283A", "/dots24567": "\u287A", "/dots245678": "\u28FA", "/dots24568": "\u28BA", "/dots2457": "\u285A", "/dots24578": "\u28DA", "/dots2458": "\u289A", "/dots246": "\u282A", "/dots2467": "\u286A", "/dots24678": "\u28EA", "/dots2468": "\u28AA", "/dots247": "\u284A", "/dots2478": "\u28CA", "/dots248": "\u288A", "/dots25": "\u2812", "/dots256": "\u2832", "/dots2567": "\u2872", "/dots25678": "\u28F2", "/dots2568": "\u28B2", "/dots257": "\u2852", "/dots2578": "\u28D2", "/dots258": "\u2892", "/dots26": "\u2822", "/dots267": "\u2862", "/dots2678": "\u28E2", "/dots268": "\u28A2", "/dots27": "\u2842", "/dots278": "\u28C2", "/dots28": "\u2882", "/dots3": "\u2804", "/dots34": "\u280C", "/dots345": "\u281C", "/dots3456": "\u283C", "/dots34567": "\u287C", "/dots345678": "\u28FC", "/dots34568": "\u28BC", "/dots3457": "\u285C", "/dots34578": "\u28DC", "/dots3458": "\u289C", "/dots346": "\u282C", "/dots3467": "\u286C", "/dots34678": "\u28EC", "/dots3468": "\u28AC", "/dots347": "\u284C", "/dots3478": "\u28CC", "/dots348": "\u288C", "/dots35": "\u2814", "/dots356": "\u2834", "/dots3567": "\u2874", "/dots35678": "\u28F4", "/dots3568": "\u28B4", "/dots357": "\u2854", "/dots3578": "\u28D4", "/dots358": "\u2894", "/dots36": "\u2824", "/dots367": "\u2864", "/dots3678": "\u28E4", "/dots368": "\u28A4", "/dots37": "\u2844", "/dots378": "\u28C4", "/dots38": "\u2884", "/dots4": "\u2808", "/dots45": "\u2818", "/dots456": "\u2838", "/dots4567": "\u2878", "/dots45678": "\u28F8", "/dots4568": "\u28B8", "/dots457": "\u2858", "/dots4578": "\u28D8", "/dots458": "\u2898", "/dots46": "\u2828", "/dots467": "\u2868", "/dots4678": "\u28E8", "/dots468": "\u28A8", "/dots47": "\u2848", "/dots478": "\u28C8", "/dots48": "\u2888", "/dots5": "\u2810", "/dots56": "\u2830", "/dots567": "\u2870", "/dots5678": "\u28F0", "/dots568": "\u28B0", "/dots57": "\u2850", "/dots578": "\u28D0", "/dots58": "\u2890", "/dots6": "\u2820", "/dots67": "\u2860", "/dots678": "\u28E0", "/dots68": "\u28A0", "/dots7": "\u2840", "/dots78": "\u28C0", "/dots8": "\u2880", "/dotsquarefour": "\u2E2C", "/dottedcircle": "\u25CC", "/dottedcross": "\u205C", "/dotupper:hb": "\u05C4", "/doublebarvertical": "\u23F8", "/doubleyodpatah": "\uFB1F", "/doubleyodpatahhebrew": "\uFB1F", "/doughnut": "\u1F369", "/doveOfPeace": "\u1F54A", "/downtackbelowcmb": "\u031E", "/downtackmod": "\u02D5", "/downwarrowleftofuparrow": "\u21F5", "/dparen": "\u249F", "/dparenthesized": "\u249F", "/drachma": "\u20AF", "/dragon": "\u1F409", "/dragonFace": "\u1F432", "/draughtskingblack": "\u26C3", "/draughtskingwhite": "\u26C1", "/draughtsmanblack": "\u26C2", "/draughtsmanwhite": "\u26C0", "/dress": "\u1F457", "/driveslow": "\u26DA", "/dromedaryCamel": "\u1F42A", "/droplet": "\u1F4A7", "/dsquare": "\u1F1A5", "/dsuperior": "\uF6EB", "/dtail": "\u0256", "/dtopbar": "\u018C", "/duhiragana": "\u3065", "/dukatakana": "\u30C5", "/dul": "\u068E", "/dul.fina": "\uFB87", "/dul.isol": "\uFB86", "/dum": "\uA771", "/dvd": "\u1F4C0", "/dyeh": "\u0684", "/dyeh.fina": "\uFB73", "/dyeh.init": "\uFB74", "/dyeh.isol": "\uFB72", "/dyeh.medi": "\uFB75", "/dz": "\u01F3", "/dzaltone": "\u02A3", "/dzcaron": "\u01C6", "/dzcurl": "\u02A5", "/dzeabkhasiancyrillic": "\u04E1", "/dzeabkhcyr": "\u04E1", "/dzecyr": "\u0455", "/dzecyrillic": "\u0455", "/dzed": "\u02A3", "/dzedcurl": "\u02A5", "/dzhecyr": "\u045F", "/dzhecyrillic": "\u045F", "/dzjekomicyr": "\u0507", "/dzzhecyr": "\u052B", "/e": "\u0065", "/e-mail": "\u1F4E7", "/e.fina": "\uFBE5", "/e.inferior": "\u2091", "/e.init": "\uFBE6", "/e.isol": "\uFBE4", "/e.medi": "\uFBE7", "/eVfullwidth": "\u32CE", "/eacute": "\u00E9", "/earOfMaize": "\u1F33D", "/earOfRice": "\u1F33E", "/earth": "\u2641", "/earthGlobeAmericas": "\u1F30E", "/earthGlobeAsiaAustralia": "\u1F30F", "/earthGlobeEuropeAfrica": "\u1F30D", "/earthground": "\u23DA", "/earthideographiccircled": "\u328F", "/earthideographicparen": "\u322F", "/eastsyriaccross": "\u2671", "/ebengali": "\u098F", "/ebopomofo": "\u311C", "/ebreve": "\u0115", "/ecandradeva": "\u090D", "/ecandragujarati": "\u0A8D", "/ecandravowelsigndeva": "\u0945", "/ecandravowelsigngujarati": "\u0AC5", "/ecaron": "\u011B", "/ecedilla": "\u0229", "/ecedillabreve": "\u1E1D", "/echarmenian": "\u0565", "/echyiwnarmenian": "\u0587", "/ecircle": "\u24D4", "/ecirclekatakana": "\u32D3", "/ecircumflex": "\u00EA", "/ecircumflexacute": "\u1EBF", "/ecircumflexbelow": "\u1E19", "/ecircumflexdotbelow": "\u1EC7", "/ecircumflexgrave": "\u1EC1", "/ecircumflexhoi": "\u1EC3", "/ecircumflexhookabove": "\u1EC3", "/ecircumflextilde": "\u1EC5", "/ecyrillic": "\u0454", "/edblgrave": "\u0205", "/edblstruckitalic": "\u2147", "/edeva": "\u090F", "/edieresis": "\u00EB", "/edot": "\u0117", "/edotaccent": "\u0117", "/edotbelow": "\u1EB9", "/eegurmukhi": "\u0A0F", "/eekaasquare": "\u3308", "/eematragurmukhi": "\u0A47", "/efcyr": "\u0444", "/efcyrillic": "\u0444", "/egrave": "\u00E8", "/egravedbl": "\u0205", "/egujarati": "\u0A8F", "/egyptain": "\uA725", "/egyptalef": "\uA723", "/eharmenian": "\u0567", "/ehbopomofo": "\u311D", "/ehiragana": "\u3048", "/ehoi": "\u1EBB", "/ehookabove": "\u1EBB", "/eibopomofo": "\u311F", "/eight": "\u0038", "/eight.inferior": "\u2088", "/eight.roman": "\u2167", "/eight.romansmall": "\u2177", "/eight.superior": "\u2078", "/eightarabic": "\u0668", "/eightbengali": "\u09EE", "/eightcircle": "\u2467", "/eightcircledbl": "\u24FC", "/eightcircleinversesansserif": "\u2791", "/eightcomma": "\u1F109", "/eightdeva": "\u096E", "/eighteencircle": "\u2471", "/eighteencircleblack": "\u24F2", "/eighteenparen": "\u2485", "/eighteenparenthesized": "\u2485", "/eighteenperiod": "\u2499", "/eightfar": "\u06F8", "/eightgujarati": "\u0AEE", "/eightgurmukhi": "\u0A6E", "/eighthackarabic": "\u0668", "/eighthangzhou": "\u3028", "/eighthnote": "\u266A", "/eighthnotebeamed": "\u266B", "/eightideographiccircled": "\u3287", "/eightideographicparen": "\u3227", "/eightinferior": "\u2088", "/eightksquare": "\u1F19F", "/eightmonospace": "\uFF18", "/eightoldstyle": "\uF738", "/eightparen": "\u247B", "/eightparenthesized": "\u247B", "/eightperiod": "\u248F", "/eightpersian": "\u06F8", "/eightroman": "\u2177", "/eightsuperior": "\u2078", "/eightthai": "\u0E58", "/eightycirclesquare": "\u324F", "/einvertedbreve": "\u0207", "/eiotifiedcyr": "\u0465", "/eiotifiedcyrillic": "\u0465", "/eject": "\u23CF", "/ekatakana": "\u30A8", "/ekatakanahalfwidth": "\uFF74", "/ekonkargurmukhi": "\u0A74", "/ekorean": "\u3154", "/elcyr": "\u043B", "/elcyrillic": "\u043B", "/electricLightBulb": "\u1F4A1", "/electricPlug": "\u1F50C", "/electricTorch": "\u1F526", "/electricalintersection": "\u23E7", "/electricarrow": "\u2301", "/element": "\u2208", "/elementdotabove": "\u22F5", "/elementlonghorizontalstroke": "\u22F2", "/elementopeningup": "\u27D2", "/elementoverbar": "\u22F6", "/elementoverbarsmall": "\u22F7", "/elementsmall": "\u220A", "/elementsmallverticalbarhorizontalstroke": "\u22F4", "/elementtwoshorizontalstroke": "\u22F9", "/elementunderbar": "\u22F8", "/elementverticalbarhorizontalstroke": "\u22F3", "/elephant": "\u1F418", "/eleven.roman": "\u216A", "/eleven.romansmall": "\u217A", "/elevencircle": "\u246A", "/elevencircleblack": "\u24EB", "/elevenparen": "\u247E", "/elevenparenthesized": "\u247E", "/elevenperiod": "\u2492", "/elevenroman": "\u217A", "/elhookcyr": "\u0513", "/ellipsis": "\u2026", "/ellipsisdiagonaldownright": "\u22F1", "/ellipsisdiagonalupright": "\u22F0", "/ellipsismidhorizontal": "\u22EF", "/ellipsisvertical": "\u22EE", "/elmiddlehookcyr": "\u0521", "/elsharptailcyr": "\u04C6", "/eltailcyr": "\u052F", "/emacron": "\u0113", "/emacronacute": "\u1E17", "/emacrongrave": "\u1E15", "/emcyr": "\u043C", "/emcyrillic": "\u043C", "/emdash": "\u2014", "/emdashdbl": "\u2E3A", "/emdashtpl": "\u2E3B", "/emdashvertical": "\uFE31", "/emojiModifierFitzpatrickType-1-2": "\u1F3FB", "/emojiModifierFitzpatrickType-3": "\u1F3FC", "/emojiModifierFitzpatrickType-4": "\u1F3FD", "/emojiModifierFitzpatrickType-5": "\u1F3FE", "/emojiModifierFitzpatrickType-6": "\u1F3FF", "/emonospace": "\uFF45", "/emphasis": "\u2383", "/emphasismarkarmenian": "\u055B", "/emptyDocument": "\u1F5CB", "/emptyNote": "\u1F5C5", "/emptyNotePad": "\u1F5C7", "/emptyNotePage": "\u1F5C6", "/emptyPage": "\u1F5CC", "/emptyPages": "\u1F5CD", "/emptyset": "\u2205", "/emquad": "\u2001", "/emsharptailcyr": "\u04CE", "/emspace": "\u2003", "/enbopomofo": "\u3123", "/encyr": "\u043D", "/encyrillic": "\u043D", "/endLeftwardsArrowAbove": "\u1F51A", "/endash": "\u2013", "/endashvertical": "\uFE32", "/endescendercyrillic": "\u04A3", "/endpro": "\u220E", "/eng": "\u014B", "/engbopomofo": "\u3125", "/engecyr": "\u04A5", "/enghecyrillic": "\u04A5", "/enhookcyr": "\u04C8", "/enhookcyrillic": "\u04C8", "/enhookleftcyr": "\u0529", "/enmiddlehookcyr": "\u0523", "/enotch": "\u2C78", "/enquad": "\u2000", "/ensharptailcyr": "\u04CA", "/enspace": "\u2002", "/entailcyr": "\u04A3", "/enter": "\u2386", "/enterpriseideographiccircled": "\u32AD", "/enterpriseideographicparen": "\u323D", "/envelopeDownwardsArrowAbove": "\u1F4E9", "/envelopeLightning": "\u1F584", "/eogonek": "\u0119", "/eokorean": "\u3153", "/eopen": "\u025B", "/eopenclosed": "\u029A", "/eopenreversed": "\u025C", "/eopenreversedclosed": "\u025E", "/eopenreversedhook": "\u025D", "/eparen": "\u24A0", "/eparenthesized": "\u24A0", "/epsilon": "\u03B5", "/epsilonacute": "\u1F73", "/epsilonasper": "\u1F11", "/epsilonasperacute": "\u1F15", "/epsilonaspergrave": "\u1F13", "/epsilongrave": "\u1F72", "/epsilonlenis": "\u1F10", "/epsilonlenisacute": "\u1F14", "/epsilonlenisgrave": "\u1F12", "/epsilonlunatesymbol": "\u03F5", "/epsilonreversedlunatesymbol": "\u03F6", "/epsilontonos": "\u03AD", "/epsilonunderlinefunc": "\u2377", "/equal": "\u003D", "/equal.inferior": "\u208C", "/equal.superior": "\u207C", "/equalandparallel": "\u22D5", "/equalbydefinition": "\u225D", "/equalmonospace": "\uFF1D", "/equalorgreater": "\u22DD", "/equalorless": "\u22DC", "/equalorprecedes": "\u22DE", "/equalorsucceeds": "\u22DF", "/equalscolon": "\u2255", "/equalsmall": "\uFE66", "/equalsuperior": "\u207C", "/equiangular": "\u225A", "/equivalence": "\u2261", "/equivalent": "\u224D", "/eranameheiseisquare": "\u337B", "/eranamemeizisquare": "\u337E", "/eranamesyouwasquare": "\u337C", "/eranametaisyousquare": "\u337D", "/eraseleft": "\u232B", "/eraseright": "\u2326", "/erbopomofo": "\u3126", "/ercyr": "\u0440", "/ercyrillic": "\u0440", "/ereversed": "\u0258", "/ereversedcyr": "\u044D", "/ereversedcyrillic": "\u044D", "/ereverseddieresiscyr": "\u04ED", "/ergfullwidth": "\u32CD", "/ertickcyr": "\u048F", "/escript": "\u212F", "/escyr": "\u0441", "/escyrillic": "\u0441", "/esdescendercyrillic": "\u04AB", "/esh": "\u0283", "/eshcurl": "\u0286", "/eshortdeva": "\u090E", "/eshortvowelsigndeva": "\u0946", "/eshreversedloop": "\u01AA", "/eshsquatreversed": "\u0285", "/esmallhiragana": "\u3047", "/esmallkatakana": "\u30A7", "/esmallkatakanahalfwidth": "\uFF6A", "/estailcyr": "\u04AB", "/estimated": "\u212E", "/estimates": "\u2259", "/estroke": "\u0247", "/esukuudosquare": "\u3307", "/esuperior": "\uF6EC", "/et": "\uA76B", "/eta": "\u03B7", "/etaacute": "\u1F75", "/etaacuteiotasub": "\u1FC4", "/etaasper": "\u1F21", "/etaasperacute": "\u1F25", "/etaasperacuteiotasub": "\u1F95", "/etaaspergrave": "\u1F23", "/etaaspergraveiotasub": "\u1F93", "/etaasperiotasub": "\u1F91", "/etaaspertilde": "\u1F27", "/etaaspertildeiotasub": "\u1F97", "/etagrave": "\u1F74", "/etagraveiotasub": "\u1FC2", "/etaiotasub": "\u1FC3", "/etalenis": "\u1F20", "/etalenisacute": "\u1F24", "/etalenisacuteiotasub": "\u1F94", "/etalenisgrave": "\u1F22", "/etalenisgraveiotasub": "\u1F92", "/etalenisiotasub": "\u1F90", "/etalenistilde": "\u1F26", "/etalenistildeiotasub": "\u1F96", "/etarmenian": "\u0568", "/etatilde": "\u1FC6", "/etatildeiotasub": "\u1FC7", "/etatonos": "\u03AE", "/eth": "\u00F0", "/ethi:aaglottal": "\u12A3", "/ethi:aglottal": "\u12A0", "/ethi:ba": "\u1260", "/ethi:baa": "\u1263", "/ethi:be": "\u1265", "/ethi:bee": "\u1264", "/ethi:bi": "\u1262", "/ethi:bo": "\u1266", "/ethi:bu": "\u1261", "/ethi:bwa": "\u1267", "/ethi:ca": "\u1278", "/ethi:caa": "\u127B", "/ethi:ce": "\u127D", "/ethi:cee": "\u127C", "/ethi:cha": "\u1328", "/ethi:chaa": "\u132B", "/ethi:che": "\u132D", "/ethi:chee": "\u132C", "/ethi:chi": "\u132A", "/ethi:cho": "\u132E", "/ethi:chu": "\u1329", "/ethi:chwa": "\u132F", "/ethi:ci": "\u127A", "/ethi:co": "\u127E", "/ethi:colon": "\u1365", "/ethi:comma": "\u1363", "/ethi:cu": "\u1279", "/ethi:cwa": "\u127F", "/ethi:da": "\u12F0", "/ethi:daa": "\u12F3", "/ethi:dda": "\u12F8", "/ethi:ddaa": "\u12FB", "/ethi:dde": "\u12FD", "/ethi:ddee": "\u12FC", "/ethi:ddi": "\u12FA", "/ethi:ddo": "\u12FE", "/ethi:ddu": "\u12F9", "/ethi:ddwa": "\u12FF", "/ethi:de": "\u12F5", "/ethi:dee": "\u12F4", "/ethi:di": "\u12F2", "/ethi:do": "\u12F6", "/ethi:du": "\u12F1", "/ethi:dwa": "\u12F7", "/ethi:eeglottal": "\u12A4", "/ethi:eglottal": "\u12A5", "/ethi:eight": "\u1370", "/ethi:eighty": "\u1379", "/ethi:fa": "\u1348", "/ethi:faa": "\u134B", "/ethi:fe": "\u134D", "/ethi:fee": "\u134C", "/ethi:fi": "\u134A", "/ethi:fifty": "\u1376", "/ethi:five": "\u136D", "/ethi:fo": "\u134E", "/ethi:forty": "\u1375", "/ethi:four": "\u136C", "/ethi:fu": "\u1349", "/ethi:fullstop": "\u1362", "/ethi:fwa": "\u134F", "/ethi:fya": "\u135A", "/ethi:ga": "\u1308", "/ethi:gaa": "\u130B", "/ethi:ge": "\u130D", "/ethi:gee": "\u130C", "/ethi:geminationandvowellengthmarkcmb": "\u135D", "/ethi:geminationmarkcmb": "\u135F", "/ethi:gga": "\u1318", "/ethi:ggaa": "\u131B", "/ethi:gge": "\u131D", "/ethi:ggee": "\u131C", "/ethi:ggi": "\u131A", "/ethi:ggo": "\u131E", "/ethi:ggu": "\u1319", "/ethi:ggwaa": "\u131F", "/ethi:gi": "\u130A", "/ethi:go": "\u130E", "/ethi:goa": "\u130F", "/ethi:gu": "\u1309", "/ethi:gwa": "\u1310", "/ethi:gwaa": "\u1313", "/ethi:gwe": "\u1315", "/ethi:gwee": "\u1314", "/ethi:gwi": "\u1312", "/ethi:ha": "\u1200", "/ethi:haa": "\u1203", "/ethi:he": "\u1205", "/ethi:hee": "\u1204", "/ethi:hha": "\u1210", "/ethi:hhaa": "\u1213", "/ethi:hhe": "\u1215", "/ethi:hhee": "\u1214", "/ethi:hhi": "\u1212", "/ethi:hho": "\u1216", "/ethi:hhu": "\u1211", "/ethi:hhwa": "\u1217", "/ethi:hi": "\u1202", "/ethi:ho": "\u1206", "/ethi:hoa": "\u1207", "/ethi:hu": "\u1201", "/ethi:hundred": "\u137B", "/ethi:iglottal": "\u12A2", "/ethi:ja": "\u1300", "/ethi:jaa": "\u1303", "/ethi:je": "\u1305", "/ethi:jee": "\u1304", "/ethi:ji": "\u1302", "/ethi:jo": "\u1306", "/ethi:ju": "\u1301", "/ethi:jwa": "\u1307", "/ethi:ka": "\u12A8", "/ethi:kaa": "\u12AB", "/ethi:ke": "\u12AD", "/ethi:kee": "\u12AC", "/ethi:ki": "\u12AA", "/ethi:ko": "\u12AE", "/ethi:koa": "\u12AF", "/ethi:ku": "\u12A9", "/ethi:kwa": "\u12B0", "/ethi:kwaa": "\u12B3", "/ethi:kwe": "\u12B5", "/ethi:kwee": "\u12B4", "/ethi:kwi": "\u12B2", "/ethi:kxa": "\u12B8", "/ethi:kxaa": "\u12BB", "/ethi:kxe": "\u12BD", "/ethi:kxee": "\u12BC", "/ethi:kxi": "\u12BA", "/ethi:kxo": "\u12BE", "/ethi:kxu": "\u12B9", "/ethi:kxwa": "\u12C0", "/ethi:kxwaa": "\u12C3", "/ethi:kxwe": "\u12C5", "/ethi:kxwee": "\u12C4", "/ethi:kxwi": "\u12C2", "/ethi:la": "\u1208", "/ethi:laa": "\u120B", "/ethi:le": "\u120D", "/ethi:lee": "\u120C", "/ethi:li": "\u120A", "/ethi:lo": "\u120E", "/ethi:lu": "\u1209", "/ethi:lwa": "\u120F", "/ethi:ma": "\u1218", "/ethi:maa": "\u121B", "/ethi:me": "\u121D", "/ethi:mee": "\u121C", "/ethi:mi": "\u121A", "/ethi:mo": "\u121E", "/ethi:mu": "\u1219", "/ethi:mwa": "\u121F", "/ethi:mya": "\u1359", "/ethi:na": "\u1290", "/ethi:naa": "\u1293", "/ethi:ne": "\u1295", "/ethi:nee": "\u1294", "/ethi:ni": "\u1292", "/ethi:nine": "\u1371", "/ethi:ninety": "\u137A", "/ethi:no": "\u1296", "/ethi:nu": "\u1291", "/ethi:nwa": "\u1297", "/ethi:nya": "\u1298", "/ethi:nyaa": "\u129B", "/ethi:nye": "\u129D", "/ethi:nyee": "\u129C", "/ethi:nyi": "\u129A", "/ethi:nyo": "\u129E", "/ethi:nyu": "\u1299", "/ethi:nywa": "\u129F", "/ethi:oglottal": "\u12A6", "/ethi:one": "\u1369", "/ethi:pa": "\u1350", "/ethi:paa": "\u1353", "/ethi:paragraphseparator": "\u1368", "/ethi:pe": "\u1355", "/ethi:pee": "\u1354", "/ethi:pha": "\u1330", "/ethi:phaa": "\u1333", "/ethi:pharyngeala": "\u12D0", "/ethi:pharyngealaa": "\u12D3", "/ethi:pharyngeale": "\u12D5", "/ethi:pharyngealee": "\u12D4", "/ethi:pharyngeali": "\u12D2", "/ethi:pharyngealo": "\u12D6", "/ethi:pharyngealu": "\u12D1", "/ethi:phe": "\u1335", "/ethi:phee": "\u1334", "/ethi:phi": "\u1332", "/ethi:pho": "\u1336", "/ethi:phu": "\u1331", "/ethi:phwa": "\u1337", "/ethi:pi": "\u1352", "/ethi:po": "\u1356", "/ethi:prefacecolon": "\u1366", "/ethi:pu": "\u1351", "/ethi:pwa": "\u1357", "/ethi:qa": "\u1240", "/ethi:qaa": "\u1243", "/ethi:qe": "\u1245", "/ethi:qee": "\u1244", "/ethi:qha": "\u1250", "/ethi:qhaa": "\u1253", "/ethi:qhe": "\u1255", "/ethi:qhee": "\u1254", "/ethi:qhi": "\u1252", "/ethi:qho": "\u1256", "/ethi:qhu": "\u1251", "/ethi:qhwa": "\u1258", "/ethi:qhwaa": "\u125B", "/ethi:qhwe": "\u125D", "/ethi:qhwee": "\u125C", "/ethi:qhwi": "\u125A", "/ethi:qi": "\u1242", "/ethi:qo": "\u1246", "/ethi:qoa": "\u1247", "/ethi:qu": "\u1241", "/ethi:questionmark": "\u1367", "/ethi:qwa": "\u1248", "/ethi:qwaa": "\u124B", "/ethi:qwe": "\u124D", "/ethi:qwee": "\u124C", "/ethi:qwi": "\u124A", "/ethi:ra": "\u1228", "/ethi:raa": "\u122B", "/ethi:re": "\u122D", "/ethi:ree": "\u122C", "/ethi:ri": "\u122A", "/ethi:ro": "\u122E", "/ethi:ru": "\u1229", "/ethi:rwa": "\u122F", "/ethi:rya": "\u1358", "/ethi:sa": "\u1230", "/ethi:saa": "\u1233", "/ethi:se": "\u1235", "/ethi:sectionmark": "\u1360", "/ethi:see": "\u1234", "/ethi:semicolon": "\u1364", "/ethi:seven": "\u136F", "/ethi:seventy": "\u1378", "/ethi:sha": "\u1238", "/ethi:shaa": "\u123B", "/ethi:she": "\u123D", "/ethi:shee": "\u123C", "/ethi:shi": "\u123A", "/ethi:sho": "\u123E", "/ethi:shu": "\u1239", "/ethi:shwa": "\u123F", "/ethi:si": "\u1232", "/ethi:six": "\u136E", "/ethi:sixty": "\u1377", "/ethi:so": "\u1236", "/ethi:su": "\u1231", "/ethi:swa": "\u1237", "/ethi:sza": "\u1220", "/ethi:szaa": "\u1223", "/ethi:sze": "\u1225", "/ethi:szee": "\u1224", "/ethi:szi": "\u1222", "/ethi:szo": "\u1226", "/ethi:szu": "\u1221", "/ethi:szwa": "\u1227", "/ethi:ta": "\u1270", "/ethi:taa": "\u1273", "/ethi:te": "\u1275", "/ethi:tee": "\u1274", "/ethi:ten": "\u1372", "/ethi:tenthousand": "\u137C", "/ethi:tha": "\u1320", "/ethi:thaa": "\u1323", "/ethi:the": "\u1325", "/ethi:thee": "\u1324", "/ethi:thi": "\u1322", "/ethi:thirty": "\u1374", "/ethi:tho": "\u1326", "/ethi:three": "\u136B", "/ethi:thu": "\u1321", "/ethi:thwa": "\u1327", "/ethi:ti": "\u1272", "/ethi:to": "\u1276", "/ethi:tsa": "\u1338", "/ethi:tsaa": "\u133B", "/ethi:tse": "\u133D", "/ethi:tsee": "\u133C", "/ethi:tsi": "\u133A", "/ethi:tso": "\u133E", "/ethi:tsu": "\u1339", "/ethi:tswa": "\u133F", "/ethi:tu": "\u1271", "/ethi:twa": "\u1277", "/ethi:twenty": "\u1373", "/ethi:two": "\u136A", "/ethi:tza": "\u1340", "/ethi:tzaa": "\u1343", "/ethi:tze": "\u1345", "/ethi:tzee": "\u1344", "/ethi:tzi": "\u1342", "/ethi:tzo": "\u1346", "/ethi:tzoa": "\u1347", "/ethi:tzu": "\u1341", "/ethi:uglottal": "\u12A1", "/ethi:va": "\u1268", "/ethi:vaa": "\u126B", "/ethi:ve": "\u126D", "/ethi:vee": "\u126C", "/ethi:vi": "\u126A", "/ethi:vo": "\u126E", "/ethi:vowellengthmarkcmb": "\u135E", "/ethi:vu": "\u1269", "/ethi:vwa": "\u126F", "/ethi:wa": "\u12C8", "/ethi:waa": "\u12CB", "/ethi:waglottal": "\u12A7", "/ethi:we": "\u12CD", "/ethi:wee": "\u12CC", "/ethi:wi": "\u12CA", "/ethi:wo": "\u12CE", "/ethi:woa": "\u12CF", "/ethi:wordspace": "\u1361", "/ethi:wu": "\u12C9", "/ethi:xa": "\u1280", "/ethi:xaa": "\u1283", "/ethi:xe": "\u1285", "/ethi:xee": "\u1284", "/ethi:xi": "\u1282", "/ethi:xo": "\u1286", "/ethi:xoa": "\u1287", "/ethi:xu": "\u1281", "/ethi:xwa": "\u1288", "/ethi:xwaa": "\u128B", "/ethi:xwe": "\u128D", "/ethi:xwee": "\u128C", "/ethi:xwi": "\u128A", "/ethi:ya": "\u12E8", "/ethi:yaa": "\u12EB", "/ethi:ye": "\u12ED", "/ethi:yee": "\u12EC", "/ethi:yi": "\u12EA", "/ethi:yo": "\u12EE", "/ethi:yoa": "\u12EF", "/ethi:yu": "\u12E9", "/ethi:za": "\u12D8", "/ethi:zaa": "\u12DB", "/ethi:ze": "\u12DD", "/ethi:zee": "\u12DC", "/ethi:zha": "\u12E0", "/ethi:zhaa": "\u12E3", "/ethi:zhe": "\u12E5", "/ethi:zhee": "\u12E4", "/ethi:zhi": "\u12E2", "/ethi:zho": "\u12E6", "/ethi:zhu": "\u12E1", "/ethi:zhwa": "\u12E7", "/ethi:zi": "\u12DA", "/ethi:zo": "\u12DE", "/ethi:zu": "\u12D9", "/ethi:zwa": "\u12DF", "/etilde": "\u1EBD", "/etildebelow": "\u1E1B", "/etnahta:hb": "\u0591", "/etnahtafoukhhebrew": "\u0591", "/etnahtafoukhlefthebrew": "\u0591", "/etnahtahebrew": "\u0591", "/etnahtalefthebrew": "\u0591", "/eturned": "\u01DD", "/eukorean": "\u3161", "/eukrcyr": "\u0454", "/euler": "\u2107", "/euro": "\u20AC", "/euroarchaic": "\u20A0", "/europeanCastle": "\u1F3F0", "/europeanPostOffice": "\u1F3E4", "/evergreenTree": "\u1F332", "/evowelsignbengali": "\u09C7", "/evowelsigndeva": "\u0947", "/evowelsigngujarati": "\u0AC7", "/excellentideographiccircled": "\u329D", "/excess": "\u2239", "/exclam": "\u0021", "/exclamarmenian": "\u055C", "/exclamationquestion": "\u2049", "/exclamdbl": "\u203C", "/exclamdown": "\u00A1", "/exclamdownsmall": "\uF7A1", "/exclammonospace": "\uFF01", "/exclamsmall": "\uF721", "/existential": "\u2203", "/expressionlessFace": "\u1F611", "/extraterrestrialAlien": "\u1F47D", "/eye": "\u1F441", "/eyeglasses": "\u1F453", "/eyes": "\u1F440", "/ezh": "\u0292", "/ezhcaron": "\u01EF", "/ezhcurl": "\u0293", "/ezhreversed": "\u01B9", "/ezhtail": "\u01BA", "/f": "\u0066", "/f_f": "\uFB00", "/f_f_i": "\uFB03", "/f_f_l": "\uFB04", "/faceMassage": "\u1F486", "/faceSavouringDeliciousFood": "\u1F60B", "/faceScreamingInFear": "\u1F631", "/faceThrowingAKiss": "\u1F618", "/faceWithColdSweat": "\u1F613", "/faceWithLookOfTriumph": "\u1F624", "/faceWithMedicalMask": "\u1F637", "/faceWithNoGoodGesture": "\u1F645", "/faceWithOkGesture": "\u1F646", "/faceWithOpenMouth": "\u1F62E", "/faceWithOpenMouthAndColdSweat": "\u1F630", "/faceWithRollingEyes": "\u1F644", "/faceWithStuckOutTongue": "\u1F61B", "/faceWithStuckOutTongueAndTightlyClosedEyes": "\u1F61D", "/faceWithStuckOutTongueAndWinkingEye": "\u1F61C", "/faceWithTearsOfJoy": "\u1F602", "/faceWithoutMouth": "\u1F636", "/facsimile": "\u213B", "/factory": "\u1F3ED", "/fadeva": "\u095E", "/fagurmukhi": "\u0A5E", "/fahrenheit": "\u2109", "/fallenLeaf": "\u1F342", "/fallingdiagonal": "\u27CD", "/fallingdiagonalincircleinsquareblackwhite": "\u26DE", "/family": "\u1F46A", "/farsi": "\u262B", "/farsiYehDigitFourBelow": "\u0777", "/farsiYehDigitThreeAbove": "\u0776", "/farsiYehDigitTwoAbove": "\u0775", "/fatha": "\u064E", "/fathaIsol": "\uFE76", "/fathaMedi": "\uFE77", "/fathaarabic": "\u064E", "/fathalowarabic": "\u064E", "/fathasmall": "\u0618", "/fathatan": "\u064B", "/fathatanIsol": "\uFE70", "/fathatanarabic": "\u064B", "/fathatwodotsdots": "\u065E", "/fatherChristmas": "\u1F385", "/faxIcon": "\u1F5B7", "/faxMachine": "\u1F4E0", "/fbopomofo": "\u3108", "/fcircle": "\u24D5", "/fdot": "\u1E1F", "/fdotaccent": "\u1E1F", "/fearfulFace": "\u1F628", "/februarytelegraph": "\u32C1", "/feh.fina": "\uFED2", "/feh.init": "\uFED3", "/feh.init_alefmaksura.fina": "\uFC31", "/feh.init_hah.fina": "\uFC2E", "/feh.init_hah.medi": "\uFCBF", "/feh.init_jeem.fina": "\uFC2D", "/feh.init_jeem.medi": "\uFCBE", "/feh.init_khah.fina": "\uFC2F", "/feh.init_khah.medi": "\uFCC0", "/feh.init_khah.medi_meem.medi": "\uFD7D", "/feh.init_meem.fina": "\uFC30", "/feh.init_meem.medi": "\uFCC1", "/feh.init_yeh.fina": "\uFC32", "/feh.isol": "\uFED1", "/feh.medi": "\uFED4", "/feh.medi_alefmaksura.fina": "\uFC7C", "/feh.medi_khah.medi_meem.fina": "\uFD7C", "/feh.medi_meem.medi_yeh.fina": "\uFDC1", "/feh.medi_yeh.fina": "\uFC7D", "/fehThreeDotsUpBelow": "\u0761", "/fehTwoDotsBelow": "\u0760", "/feharabic": "\u0641", "/feharmenian": "\u0586", "/fehdotbelow": "\u06A3", "/fehdotbelowright": "\u06A2", "/fehfinalarabic": "\uFED2", "/fehinitialarabic": "\uFED3", "/fehmedialarabic": "\uFED4", "/fehthreedotsbelow": "\u06A5", "/feicoptic": "\u03E5", "/female": "\u2640", "/femaleideographiccircled": "\u329B", "/feng": "\u02A9", "/ferrisWheel": "\u1F3A1", "/ferry": "\u26F4", "/festivalideographicparen": "\u3240", "/ff": "\uFB00", "/ffi": "\uFB03", "/ffl": "\uFB04", "/fhook": "\u0192", "/fi": "\uFB01", # ligature "fi" "/fieldHockeyStickAndBall": "\u1F3D1", "/fifteencircle": "\u246E", "/fifteencircleblack": "\u24EF", "/fifteenparen": "\u2482", "/fifteenparenthesized": "\u2482", "/fifteenperiod": "\u2496", "/fifty.roman": "\u216C", "/fifty.romansmall": "\u217C", "/fiftycircle": "\u32BF", "/fiftycirclesquare": "\u324C", "/fiftyearlyform.roman": "\u2186", "/fiftythousand.roman": "\u2187", "/figuredash": "\u2012", "/figurespace": "\u2007", "/fileCabinet": "\u1F5C4", "/fileFolder": "\u1F4C1", "/filledbox": "\u25A0", "/filledrect": "\u25AC", "/filledstopabove": "\u06EC", "/filmFrames": "\u1F39E", "/filmProjector": "\u1F4FD", "/finalkaf": "\u05DA", "/finalkaf:hb": "\u05DA", "/finalkafdagesh": "\uFB3A", "/finalkafdageshhebrew": "\uFB3A", "/finalkafhebrew": "\u05DA", "/finalkafqamats": "\u05DA", "/finalkafqamatshebrew": "\u05DA", "/finalkafsheva": "\u05DA", "/finalkafshevahebrew": "\u05DA", "/finalkafwithdagesh:hb": "\uFB3A", "/finalmem": "\u05DD", "/finalmem:hb": "\u05DD", "/finalmemhebrew": "\u05DD", "/finalmemwide:hb": "\uFB26", "/finalnun": "\u05DF", "/finalnun:hb": "\u05DF", "/finalnunhebrew": "\u05DF", "/finalpe": "\u05E3", "/finalpe:hb": "\u05E3", "/finalpehebrew": "\u05E3", "/finalpewithdagesh:hb": "\uFB43", "/finalsigma": "\u03C2", "/finaltsadi": "\u05E5", "/finaltsadi:hb": "\u05E5", "/finaltsadihebrew": "\u05E5", "/financialideographiccircled": "\u3296", "/financialideographicparen": "\u3236", "/finsular": "\uA77C", "/fire": "\u1F525", "/fireEngine": "\u1F692", "/fireideographiccircled": "\u328B", "/fireideographicparen": "\u322B", "/fireworkSparkler": "\u1F387", "/fireworks": "\u1F386", "/firstQuarterMoon": "\u1F313", "/firstQuarterMoonFace": "\u1F31B", "/firstquartermoon": "\u263D", "/firststrongisolate": "\u2068", "/firsttonechinese": "\u02C9", "/fish": "\u1F41F", "/fishCakeSwirlDesign": "\u1F365", "/fisheye": "\u25C9", "/fishingPoleAndFish": "\u1F3A3", "/fistedHandSign": "\u1F44A", "/fitacyr": "\u0473", "/fitacyrillic": "\u0473", "/five": "\u0035", "/five.inferior": "\u2085", "/five.roman": "\u2164", "/five.romansmall": "\u2174", "/five.superior": "\u2075", "/fivearabic": "\u0665", "/fivebengali": "\u09EB", "/fivecircle": "\u2464", "/fivecircledbl": "\u24F9", "/fivecircleinversesansserif": "\u278E", "/fivecomma": "\u1F106", "/fivedeva": "\u096B", "/fivedot": "\u2E2D", "/fivedotpunctuation": "\u2059", "/fiveeighths": "\u215D", "/fivefar": "\u06F5", "/fivegujarati": "\u0AEB", "/fivegurmukhi": "\u0A6B", "/fivehackarabic": "\u0665", "/fivehangzhou": "\u3025", "/fivehundred.roman": "\u216E", "/fivehundred.romansmall": "\u217E", "/fiveideographiccircled": "\u3284", "/fiveideographicparen": "\u3224", "/fiveinferior": "\u2085", "/fivemonospace": "\uFF15", "/fiveoldstyle": "\uF735", "/fiveparen": "\u2478", "/fiveparenthesized": "\u2478", "/fiveperiod": "\u248C", "/fivepersian": "\u06F5", "/fivepointedstar": "\u066D", "/fivepointonesquare": "\u1F1A0", "/fiveroman": "\u2174", "/fivesixths": "\u215A", "/fivesuperior": "\u2075", "/fivethai": "\u0E55", "/fivethousand.roman": "\u2181", "/fl": "\uFB02", "/flagblack": "\u2691", "/flaghorizontalmiddlestripeblackwhite": "\u26FF", "/flaginhole": "\u26F3", "/flagwhite": "\u2690", "/flatness": "\u23E5", "/fleurdelis": "\u269C", "/flexedBiceps": "\u1F4AA", "/floorleft": "\u230A", "/floorright": "\u230B", "/floppyDisk": "\u1F4BE", "/floralheartbulletreversedrotated": "\u2619", "/florin": "\u0192", "/flower": "\u2698", "/flowerPlayingCards": "\u1F3B4", "/flowerpunctuationmark": "\u2055", "/flushedFace": "\u1F633", "/flyingEnvelope": "\u1F585", "/flyingSaucer": "\u1F6F8", "/fmfullwidth": "\u3399", "/fmonospace": "\uFF46", "/fmsquare": "\u3399", "/fofanthai": "\u0E1F", "/fofathai": "\u0E1D", "/fog": "\u1F32B", "/foggy": "\u1F301", "/folder": "\u1F5C0", "/fongmanthai": "\u0E4F", "/footnote": "\u0602", "/footprints": "\u1F463", "/footsquare": "\u23CD", "/forall": "\u2200", "/forces": "\u22A9", "/fork": "\u2442", "/forkKnife": "\u1F374", "/forkKnifePlate": "\u1F37D", "/forsamaritan": "\u214F", "/fortycircle": "\u32B5", "/fortycirclesquare": "\u324B", "/fortyeightcircle": "\u32BD", "/fortyfivecircle": "\u32BA", "/fortyfourcircle": "\u32B9", "/fortyninecircle": "\u32BE", "/fortyonecircle": "\u32B6", "/fortysevencircle": "\u32BC", "/fortysixcircle": "\u32BB", "/fortythreecircle": "\u32B8", "/fortytwocircle": "\u32B7", "/fountain": "\u26F2", "/four": "\u0034", "/four.inferior": "\u2084", "/four.roman": "\u2163", "/four.romansmall": "\u2173", "/four.superior": "\u2074", "/fourLeafClover": "\u1F340", "/fourarabic": "\u0664", "/fourbengali": "\u09EA", "/fourcircle": "\u2463", "/fourcircledbl": "\u24F8", "/fourcircleinversesansserif": "\u278D", "/fourcomma": "\u1F105", "/fourdeva": "\u096A", "/fourdotmark": "\u205B", "/fourdotpunctuation": "\u2058", "/fourfar": "\u06F4", "/fourfifths": "\u2158", "/fourgujarati": "\u0AEA", "/fourgurmukhi": "\u0A6A", "/fourhackarabic": "\u0664", "/fourhangzhou": "\u3024", "/fourideographiccircled": "\u3283", "/fourideographicparen": "\u3223", "/fourinferior": "\u2084", "/fourksquare": "\u1F19E", "/fourmonospace": "\uFF14", "/fournumeratorbengali": "\u09F7", "/fouroldstyle": "\uF734", "/fourparen": "\u2477", "/fourparenthesized": "\u2477", "/fourperemspace": "\u2005", "/fourperiod": "\u248B", "/fourpersian": "\u06F4", "/fourroman": "\u2173", "/foursuperior": "\u2074", "/fourteencircle": "\u246D", "/fourteencircleblack": "\u24EE", "/fourteenparen": "\u2481", "/fourteenparenthesized": "\u2481", "/fourteenperiod": "\u2495", "/fourthai": "\u0E54", "/fourthtonechinese": "\u02CB", "/fparen": "\u24A1", "/fparenthesized": "\u24A1", "/fraction": "\u2044", "/frameAnX": "\u1F5BE", "/framePicture": "\u1F5BC", "/frameTiles": "\u1F5BD", "/franc": "\u20A3", "/freesquare": "\u1F193", "/frenchFries": "\u1F35F", "/freversedepigraphic": "\uA7FB", "/friedShrimp": "\u1F364", "/frogFace": "\u1F438", "/front-facingBabyChick": "\u1F425", "/frown": "\u2322", "/frowningFaceWithOpenMouth": "\u1F626", "/frowningfacewhite": "\u2639", "/fstroke": "\uA799", "/fturned": "\u214E", "/fuelpump": "\u26FD", "/fullBlock": "\u2588", "/fullMoon": "\u1F315", "/fullMoonFace": "\u1F31D", "/functionapplication": "\u2061", "/funeralurn": "\u26B1", "/fuse": "\u23DB", "/fwd:A": "\uFF21", "/fwd:B": "\uFF22", "/fwd:C": "\uFF23", "/fwd:D": "\uFF24", "/fwd:E": "\uFF25", "/fwd:F": "\uFF26", "/fwd:G": "\uFF27", "/fwd:H": "\uFF28", "/fwd:I": "\uFF29", "/fwd:J": "\uFF2A", "/fwd:K": "\uFF2B", "/fwd:L": "\uFF2C", "/fwd:M": "\uFF2D", "/fwd:N": "\uFF2E", "/fwd:O": "\uFF2F", "/fwd:P": "\uFF30", "/fwd:Q": "\uFF31", "/fwd:R": "\uFF32", "/fwd:S": "\uFF33", "/fwd:T": "\uFF34", "/fwd:U": "\uFF35", "/fwd:V": "\uFF36", "/fwd:W": "\uFF37", "/fwd:X": "\uFF38", "/fwd:Y": "\uFF39", "/fwd:Z": "\uFF3A", "/fwd:a": "\uFF41", "/fwd:ampersand": "\uFF06", "/fwd:asciicircum": "\uFF3E", "/fwd:asciitilde": "\uFF5E", "/fwd:asterisk": "\uFF0A", "/fwd:at": "\uFF20", "/fwd:b": "\uFF42", "/fwd:backslash": "\uFF3C", "/fwd:bar": "\uFF5C", "/fwd:braceleft": "\uFF5B", "/fwd:braceright": "\uFF5D", "/fwd:bracketleft": "\uFF3B", "/fwd:bracketright": "\uFF3D", "/fwd:brokenbar": "\uFFE4", "/fwd:c": "\uFF43", "/fwd:centsign": "\uFFE0", "/fwd:colon": "\uFF1A", "/fwd:comma": "\uFF0C", "/fwd:d": "\uFF44", "/fwd:dollar": "\uFF04", "/fwd:e": "\uFF45", "/fwd:eight": "\uFF18", "/fwd:equal": "\uFF1D", "/fwd:exclam": "\uFF01", "/fwd:f": "\uFF46", "/fwd:five": "\uFF15", "/fwd:four": "\uFF14", "/fwd:g": "\uFF47", "/fwd:grave": "\uFF40", "/fwd:greater": "\uFF1E", "/fwd:h": "\uFF48", "/fwd:hyphen": "\uFF0D", "/fwd:i": "\uFF49", "/fwd:j": "\uFF4A", "/fwd:k": "\uFF4B", "/fwd:l": "\uFF4C", "/fwd:leftwhiteparenthesis": "\uFF5F", "/fwd:less": "\uFF1C", "/fwd:m": "\uFF4D", "/fwd:macron": "\uFFE3", "/fwd:n": "\uFF4E", "/fwd:nine": "\uFF19", "/fwd:notsign": "\uFFE2", "/fwd:numbersign": "\uFF03", "/fwd:o": "\uFF4F", "/fwd:one": "\uFF11", "/fwd:p": "\uFF50", "/fwd:parenthesisleft": "\uFF08", "/fwd:parenthesisright": "\uFF09", "/fwd:percent": "\uFF05", "/fwd:period": "\uFF0E", "/fwd:plus": "\uFF0B", "/fwd:poundsign": "\uFFE1", "/fwd:q": "\uFF51", "/fwd:question": "\uFF1F", "/fwd:quotedbl": "\uFF02", "/fwd:quotesingle": "\uFF07", "/fwd:r": "\uFF52", "/fwd:rightwhiteparenthesis": "\uFF60", "/fwd:s": "\uFF53", "/fwd:semicolon": "\uFF1B", "/fwd:seven": "\uFF17", "/fwd:six": "\uFF16", "/fwd:slash": "\uFF0F", "/fwd:t": "\uFF54", "/fwd:three": "\uFF13", "/fwd:two": "\uFF12", "/fwd:u": "\uFF55", "/fwd:underscore": "\uFF3F", "/fwd:v": "\uFF56", "/fwd:w": "\uFF57", "/fwd:wonsign": "\uFFE6", "/fwd:x": "\uFF58", "/fwd:y": "\uFF59", "/fwd:yensign": "\uFFE5", "/fwd:z": "\uFF5A", "/fwd:zero": "\uFF10", "/g": "\u0067", "/gabengali": "\u0997", "/gacute": "\u01F5", "/gadeva": "\u0917", "/gaf": "\u06AF", "/gaf.fina": "\uFB93", "/gaf.init": "\uFB94", "/gaf.isol": "\uFB92", "/gaf.medi": "\uFB95", "/gafarabic": "\u06AF", "/gaffinalarabic": "\uFB93", "/gafinitialarabic": "\uFB94", "/gafmedialarabic": "\uFB95", "/gafring": "\u06B0", "/gafthreedotsabove": "\u06B4", "/gaftwodotsbelow": "\u06B2", "/gagujarati": "\u0A97", "/gagurmukhi": "\u0A17", "/gahiragana": "\u304C", "/gakatakana": "\u30AC", "/galsquare": "\u33FF", "/gameDie": "\u1F3B2", "/gamma": "\u03B3", "/gammadblstruck": "\u213D", "/gammalatinsmall": "\u0263", "/gammasuperior": "\u02E0", "/gammasupmod": "\u02E0", "/gamurda": "\uA993", "/gangiacoptic": "\u03EB", "/ganmasquare": "\u330F", "/garonsquare": "\u330E", "/gbfullwidth": "\u3387", "/gbopomofo": "\u310D", "/gbreve": "\u011F", "/gcaron": "\u01E7", "/gcedilla": "\u0123", "/gcircle": "\u24D6", "/gcircumflex": "\u011D", "/gcommaaccent": "\u0123", "/gdot": "\u0121", "/gdotaccent": "\u0121", "/gear": "\u2699", "/gearhles": "\u26EE", "/gearouthub": "\u26ED", "/gecyr": "\u0433", "/gecyrillic": "\u0433", "/gehiragana": "\u3052", "/gehookcyr": "\u0495", "/gehookstrokecyr": "\u04FB", "/gekatakana": "\u30B2", "/gemStone": "\u1F48E", "/gemini": "\u264A", "/geometricallyequal": "\u2251", "/geometricallyequivalent": "\u224E", "/geometricproportion": "\u223A", "/geresh:hb": "\u05F3", "/gereshMuqdam:hb": "\u059D", "/gereshaccenthebrew": "\u059C", "/gereshhebrew": "\u05F3", "/gereshmuqdamhebrew": "\u059D", "/germandbls": "\u00DF", "/germanpenny": "\u20B0", "/gershayim:hb": "\u05F4", "/gershayimaccenthebrew": "\u059E", "/gershayimhebrew": "\u05F4", "/gestrokecyr": "\u0493", "/getailcyr": "\u04F7", "/getamark": "\u3013", "/geupcyr": "\u0491", "/ghabengali": "\u0998", "/ghadarmenian": "\u0572", "/ghadeva": "\u0918", "/ghagujarati": "\u0A98", "/ghagurmukhi": "\u0A18", "/ghain": "\u063A", "/ghain.fina": "\uFECE", "/ghain.init": "\uFECF", "/ghain.init_alefmaksura.fina": "\uFCF9", "/ghain.init_jeem.fina": "\uFC2B", "/ghain.init_jeem.medi": "\uFCBC", "/ghain.init_meem.fina": "\uFC2C", "/ghain.init_meem.medi": "\uFCBD", "/ghain.init_yeh.fina": "\uFCFA", "/ghain.isol": "\uFECD", "/ghain.medi": "\uFED0", "/ghain.medi_alefmaksura.fina": "\uFD15", "/ghain.medi_meem.medi_alefmaksura.fina": "\uFD7B", "/ghain.medi_meem.medi_meem.fina": "\uFD79", "/ghain.medi_meem.medi_yeh.fina": "\uFD7A", "/ghain.medi_yeh.fina": "\uFD16", "/ghainarabic": "\u063A", "/ghaindotbelow": "\u06FC", "/ghainfinalarabic": "\uFECE", "/ghaininitialarabic": "\uFECF", "/ghainmedialarabic": "\uFED0", "/ghemiddlehookcyrillic": "\u0495", "/ghestrokecyrillic": "\u0493", "/gheupturncyrillic": "\u0491", "/ghhadeva": "\u095A", "/ghhagurmukhi": "\u0A5A", "/ghook": "\u0260", "/ghost": "\u1F47B", "/ghzfullwidth": "\u3393", "/ghzsquare": "\u3393", "/gigasquare": "\u3310", "/gihiragana": "\u304E", "/gikatakana": "\u30AE", "/gimarmenian": "\u0563", "/gimel": "\u05D2", "/gimel:hb": "\u05D2", "/gimeldagesh": "\uFB32", "/gimeldageshhebrew": "\uFB32", "/gimelhebrew": "\u05D2", "/gimelwithdagesh:hb": "\uFB32", "/giniisquare": "\u3311", "/ginsularturned": "\uA77F", "/girl": "\u1F467", "/girls": "\u1F6CA", "/girudaasquare": "\u3313", "/gjecyr": "\u0453", "/gjecyrillic": "\u0453", "/globeMeridians": "\u1F310", "/glottalinvertedstroke": "\u01BE", "/glottalstop": "\u0294", "/glottalstopinverted": "\u0296", "/glottalstopmod": "\u02C0", "/glottalstopreversed": "\u0295", "/glottalstopreversedmod": "\u02C1", "/glottalstopreversedsuperior": "\u02E4", "/glottalstopstroke": "\u02A1", "/glottalstopstrokereversed": "\u02A2", "/glottalstopsupreversedmod": "\u02E4", "/glowingStar": "\u1F31F", "/gmacron": "\u1E21", "/gmonospace": "\uFF47", "/gmtr:diamondblack": "\u25C6", "/gmtr:diamondwhite": "\u25C7", "/gnrl:hyphen": "\u2010", "/goat": "\u1F410", "/gobliquestroke": "\uA7A1", "/gohiragana": "\u3054", "/gokatakana": "\u30B4", "/golfer": "\u1F3CC", "/gpafullwidth": "\u33AC", "/gparen": "\u24A2", "/gparenthesized": "\u24A2", "/gpasquare": "\u33AC", "/gr:acute": "\u1FFD", "/gr:grave": "\u1FEF", "/gr:question": "\u037E", "/gr:tilde": "\u1FC0", "/gradient": "\u2207", "/graduationCap": "\u1F393", "/grapes": "\u1F347", "/grave": "\u0060", "/gravebelowcmb": "\u0316", "/gravecmb": "\u0300", "/gravecomb": "\u0300", "/gravedblmiddlemod": "\u02F5", "/gravedeva": "\u0953", "/gravelowmod": "\u02CE", "/gravemiddlemod": "\u02F4", "/gravemod": "\u02CB", "/gravemonospace": "\uFF40", "/gravetonecmb": "\u0340", "/greater": "\u003E", "/greaterbutnotequal": "\u2269", "/greaterbutnotequivalent": "\u22E7", "/greaterdot": "\u22D7", "/greaterequal": "\u2265", "/greaterequalorless": "\u22DB", "/greatermonospace": "\uFF1E", "/greaterorequivalent": "\u2273", "/greaterorless": "\u2277", "/greateroverequal": "\u2267", "/greatersmall": "\uFE65", "/greenApple": "\u1F34F", "/greenBook": "\u1F4D7", "/greenHeart": "\u1F49A", "/grimacingFace": "\u1F62C", "/grinningCatFaceWithSmilingEyes": "\u1F638", "/grinningFace": "\u1F600", "/grinningFaceWithSmilingEyes": "\u1F601", "/growingHeart": "\u1F497", "/gscript": "\u0261", "/gstroke": "\u01E5", "/guarani": "\u20B2", "/guardsman": "\u1F482", "/gueh": "\u06B3", "/gueh.fina": "\uFB97", "/gueh.init": "\uFB98", "/gueh.isol": "\uFB96", "/gueh.medi": "\uFB99", "/guhiragana": "\u3050", "/guillemetleft": "\u00AB", "/guillemetright": "\u00BB", "/guillemotleft": "\u00AB", "/guillemotright": "\u00BB", "/guilsinglleft": "\u2039", "/guilsinglright": "\u203A", "/guitar": "\u1F3B8", "/gujr:a": "\u0A85", "/gujr:aa": "\u0A86", "/gujr:aasign": "\u0ABE", "/gujr:abbreviation": "\u0AF0", "/gujr:ai": "\u0A90", "/gujr:aisign": "\u0AC8", "/gujr:anusvara": "\u0A82", "/gujr:au": "\u0A94", "/gujr:ausign": "\u0ACC", "/gujr:avagraha": "\u0ABD", "/gujr:ba": "\u0AAC", "/gujr:bha": "\u0AAD", "/gujr:binducandra": "\u0A81", "/gujr:ca": "\u0A9A", "/gujr:cha": "\u0A9B", "/gujr:circlenuktaabove": "\u0AFE", "/gujr:da": "\u0AA6", "/gujr:dda": "\u0AA1", "/gujr:ddha": "\u0AA2", "/gujr:dha": "\u0AA7", "/gujr:e": "\u0A8F", "/gujr:ecandra": "\u0A8D", "/gujr:eight": "\u0AEE", "/gujr:esign": "\u0AC7", "/gujr:esigncandra": "\u0AC5", "/gujr:five": "\u0AEB", "/gujr:four": "\u0AEA", "/gujr:ga": "\u0A97", "/gujr:gha": "\u0A98", "/gujr:ha": "\u0AB9", "/gujr:i": "\u0A87", "/gujr:ii": "\u0A88", "/gujr:iisign": "\u0AC0", "/gujr:isign": "\u0ABF", "/gujr:ja": "\u0A9C", "/gujr:jha": "\u0A9D", "/gujr:ka": "\u0A95", "/gujr:kha": "\u0A96", "/gujr:la": "\u0AB2", "/gujr:lla": "\u0AB3", "/gujr:llvocal": "\u0AE1", "/gujr:llvocalsign": "\u0AE3", "/gujr:lvocal": "\u0A8C", "/gujr:lvocalsign": "\u0AE2", "/gujr:ma": "\u0AAE", "/gujr:maddah": "\u0AFC", "/gujr:na": "\u0AA8", "/gujr:nga": "\u0A99", "/gujr:nine": "\u0AEF", "/gujr:nna": "\u0AA3", "/gujr:nukta": "\u0ABC", "/gujr:nya": "\u0A9E", "/gujr:o": "\u0A93", "/gujr:ocandra": "\u0A91", "/gujr:om": "\u0AD0", "/gujr:one": "\u0AE7", "/gujr:osign": "\u0ACB", "/gujr:osigncandra": "\u0AC9", "/gujr:pa": "\u0AAA", "/gujr:pha": "\u0AAB", "/gujr:ra": "\u0AB0", "/gujr:rrvocal": "\u0AE0", "/gujr:rrvocalsign": "\u0AC4", "/gujr:rupee": "\u0AF1", "/gujr:rvocal": "\u0A8B", "/gujr:rvocalsign": "\u0AC3", "/gujr:sa": "\u0AB8", "/gujr:seven": "\u0AED", "/gujr:sha": "\u0AB6", "/gujr:shadda": "\u0AFB", "/gujr:six": "\u0AEC", "/gujr:ssa": "\u0AB7", "/gujr:sukun": "\u0AFA", "/gujr:ta": "\u0AA4", "/gujr:tha": "\u0AA5", "/gujr:three": "\u0AE9", "/gujr:three-dotnuktaabove": "\u0AFD", "/gujr:tta": "\u0A9F", "/gujr:ttha": "\u0AA0", "/gujr:two": "\u0AE8", "/gujr:two-circlenuktaabove": "\u0AFF", "/gujr:u": "\u0A89", "/gujr:usign": "\u0AC1", "/gujr:uu": "\u0A8A", "/gujr:uusign": "\u0AC2", "/gujr:va": "\u0AB5", "/gujr:virama": "\u0ACD", "/gujr:visarga": "\u0A83", "/gujr:ya": "\u0AAF", "/gujr:zero": "\u0AE6", "/gujr:zha": "\u0AF9", "/gukatakana": "\u30B0", "/guramusquare": "\u3318", "/guramutonsquare": "\u3319", "/guru:a": "\u0A05", "/guru:aa": "\u0A06", "/guru:aasign": "\u0A3E", "/guru:adakbindisign": "\u0A01", "/guru:addak": "\u0A71", "/guru:ai": "\u0A10", "/guru:aisign": "\u0A48", "/guru:au": "\u0A14", "/guru:ausign": "\u0A4C", "/guru:ba": "\u0A2C", "/guru:bha": "\u0A2D", "/guru:bindisign": "\u0A02", "/guru:ca": "\u0A1A", "/guru:cha": "\u0A1B", "/guru:da": "\u0A26", "/guru:dda": "\u0A21", "/guru:ddha": "\u0A22", "/guru:dha": "\u0A27", "/guru:ee": "\u0A0F", "/guru:eesign": "\u0A47", "/guru:eight": "\u0A6E", "/guru:ekonkar": "\u0A74", "/guru:fa": "\u0A5E", "/guru:five": "\u0A6B", "/guru:four": "\u0A6A", "/guru:ga": "\u0A17", "/guru:gha": "\u0A18", "/guru:ghha": "\u0A5A", "/guru:ha": "\u0A39", "/guru:i": "\u0A07", "/guru:ii": "\u0A08", "/guru:iisign": "\u0A40", "/guru:iri": "\u0A72", "/guru:isign": "\u0A3F", "/guru:ja": "\u0A1C", "/guru:jha": "\u0A1D", "/guru:ka": "\u0A15", "/guru:kha": "\u0A16", "/guru:khha": "\u0A59", "/guru:la": "\u0A32", "/guru:lla": "\u0A33", "/guru:ma": "\u0A2E", "/guru:na": "\u0A28", "/guru:nga": "\u0A19", "/guru:nine": "\u0A6F", "/guru:nna": "\u0A23", "/guru:nukta": "\u0A3C", "/guru:nya": "\u0A1E", "/guru:one": "\u0A67", "/guru:oo": "\u0A13", "/guru:oosign": "\u0A4B", "/guru:pa": "\u0A2A", "/guru:pha": "\u0A2B", "/guru:ra": "\u0A30", "/guru:rra": "\u0A5C", "/guru:sa": "\u0A38", "/guru:seven": "\u0A6D", "/guru:sha": "\u0A36", "/guru:six": "\u0A6C", "/guru:ta": "\u0A24", "/guru:tha": "\u0A25", "/guru:three": "\u0A69", "/guru:tippi": "\u0A70", "/guru:tta": "\u0A1F", "/guru:ttha": "\u0A20", "/guru:two": "\u0A68", "/guru:u": "\u0A09", "/guru:udaatsign": "\u0A51", "/guru:ura": "\u0A73", "/guru:usign": "\u0A41", "/guru:uu": "\u0A0A", "/guru:uusign": "\u0A42", "/guru:va": "\u0A35", "/guru:virama": "\u0A4D", "/guru:visarga": "\u0A03", "/guru:ya": "\u0A2F", "/guru:yakashsign": "\u0A75", "/guru:za": "\u0A5B", "/guru:zero": "\u0A66", "/gyfullwidth": "\u33C9", "/gysquare": "\u33C9", "/h": "\u0068", "/h.inferior": "\u2095", "/haabkhasiancyrillic": "\u04A9", "/haabkhcyr": "\u04A9", "/haaltonearabic": "\u06C1", "/habengali": "\u09B9", "/hacirclekatakana": "\u32E9", "/hacyr": "\u0445", "/hadescendercyrillic": "\u04B3", "/hadeva": "\u0939", "/hafullwidth": "\u33CA", "/hagujarati": "\u0AB9", "/hagurmukhi": "\u0A39", "/hah": "\u062D", "/hah.fina": "\uFEA2", "/hah.init": "\uFEA3", "/hah.init_alefmaksura.fina": "\uFCFF", "/hah.init_jeem.fina": "\uFC17", "/hah.init_jeem.medi": "\uFCA9", "/hah.init_meem.fina": "\uFC18", "/hah.init_meem.medi": "\uFCAA", "/hah.init_yeh.fina": "\uFD00", "/hah.isol": "\uFEA1", "/hah.medi": "\uFEA4", "/hah.medi_alefmaksura.fina": "\uFD1B", "/hah.medi_jeem.medi_yeh.fina": "\uFDBF", "/hah.medi_meem.medi_alefmaksura.fina": "\uFD5B", "/hah.medi_meem.medi_yeh.fina": "\uFD5A", "/hah.medi_yeh.fina": "\uFD1C", "/hahDigitFourBelow": "\u077C", "/hahSmallTahAbove": "\u0772", "/hahSmallTahBelow": "\u076E", "/hahSmallTahTwoDots": "\u076F", "/hahThreeDotsUpBelow": "\u0758", "/hahTwoDotsAbove": "\u0757", "/haharabic": "\u062D", "/hahfinalarabic": "\uFEA2", "/hahhamza": "\u0681", "/hahinitialarabic": "\uFEA3", "/hahiragana": "\u306F", "/hahmedialarabic": "\uFEA4", "/hahookcyr": "\u04FD", "/hahthreedotsabove": "\u0685", "/hahtwodotsvertical": "\u0682", "/haircut": "\u1F487", "/hairspace": "\u200A", "/haitusquare": "\u332A", "/hakatakana": "\u30CF", "/hakatakanahalfwidth": "\uFF8A", "/halantgurmukhi": "\u0A4D", "/halfcircleleftblack": "\u25D6", "/halfcirclerightblack": "\u25D7", "/hamburger": "\u1F354", "/hammer": "\u1F528", "/hammerAndWrench": "\u1F6E0", "/hammerpick": "\u2692", "/hammersickle": "\u262D", "/hamsterFace": "\u1F439", "/hamza": "\u0621", "/hamzaIsol": "\uFE80", "/hamzaabove": "\u0654", "/hamzaarabic": "\u0621", "/hamzabelow": "\u0655", "/hamzadammaarabic": "\u0621", "/hamzadammatanarabic": "\u0621", "/hamzafathaarabic": "\u0621", "/hamzafathatanarabic": "\u0621", "/hamzalowarabic": "\u0621", "/hamzalowkasraarabic": "\u0621", "/hamzalowkasratanarabic": "\u0621", "/hamzasukunarabic": "\u0621", "/handbag": "\u1F45C", "/handtailfishhookturned": "\u02AF", "/hangulchieuchaparen": "\u3217", "/hangulchieuchparen": "\u3209", "/hangulcieucaparen": "\u3216", "/hangulcieucparen": "\u3208", "/hangulcieucuparen": "\u321C", "/hanguldottonemarkdbl": "\u302F", "/hangulfiller": "\u3164", "/hangulhieuhaparen": "\u321B", "/hangulhieuhparen": "\u320D", "/hangulieungaparen": "\u3215", "/hangulieungparen": "\u3207", "/hangulkhieukhaparen": "\u3218", "/hangulkhieukhparen": "\u320A", "/hangulkiyeokaparen": "\u320E", "/hangulkiyeokparen": "\u3200", "/hangulmieumaparen": "\u3212", "/hangulmieumparen": "\u3204", "/hangulnieunaparen": "\u320F", "/hangulnieunparen": "\u3201", "/hangulphieuphaparen": "\u321A", "/hangulphieuphparen": "\u320C", "/hangulpieupaparen": "\u3213", "/hangulpieupparen": "\u3205", "/hangulrieulaparen": "\u3211", "/hangulrieulparen": "\u3203", "/hangulsingledottonemark": "\u302E", "/hangulsiosaparen": "\u3214", "/hangulsiosparen": "\u3206", "/hangulthieuthaparen": "\u3219", "/hangulthieuthparen": "\u320B", "/hangultikeutaparen": "\u3210", "/hangultikeutparen": "\u3202", "/happyPersonRaisingOneHand": "\u1F64B", "/hardDisk": "\u1F5B4", "/hardcyr": "\u044A", "/hardsigncyrillic": "\u044A", "/harpoondownbarbleft": "\u21C3", "/harpoondownbarbright": "\u21C2", "/harpoonleftbarbdown": "\u21BD", "/harpoonleftbarbup": "\u21BC", "/harpoonrightbarbdown": "\u21C1", "/harpoonrightbarbup": "\u21C0", "/harpoonupbarbleft": "\u21BF", "/harpoonupbarbright": "\u21BE", "/hasquare": "\u33CA", "/hastrokecyr": "\u04FF", "/hatafPatah:hb": "\u05B2", "/hatafQamats:hb": "\u05B3", "/hatafSegol:hb": "\u05B1", "/hatafpatah": "\u05B2", "/hatafpatah16": "\u05B2", "/hatafpatah23": "\u05B2", "/hatafpatah2f": "\u05B2", "/hatafpatahhebrew": "\u05B2", "/hatafpatahnarrowhebrew": "\u05B2", "/hatafpatahquarterhebrew": "\u05B2", "/hatafpatahwidehebrew": "\u05B2", "/hatafqamats": "\u05B3", "/hatafqamats1b": "\u05B3", "/hatafqamats28": "\u05B3", "/hatafqamats34": "\u05B3", "/hatafqamatshebrew": "\u05B3", "/hatafqamatsnarrowhebrew": "\u05B3", "/hatafqamatsquarterhebrew": "\u05B3", "/hatafqamatswidehebrew": "\u05B3", "/hatafsegol": "\u05B1", "/hatafsegol17": "\u05B1", "/hatafsegol24": "\u05B1", "/hatafsegol30": "\u05B1", "/hatafsegolhebrew": "\u05B1", "/hatafsegolnarrowhebrew": "\u05B1", "/hatafsegolquarterhebrew": "\u05B1", "/hatafsegolwidehebrew": "\u05B1", "/hatchingChick": "\u1F423", "/haveideographiccircled": "\u3292", "/haveideographicparen": "\u3232", "/hbar": "\u0127", "/hbopomofo": "\u310F", "/hbrevebelow": "\u1E2B", "/hcaron": "\u021F", "/hcedilla": "\u1E29", "/hcircle": "\u24D7", "/hcircumflex": "\u0125", "/hcsquare": "\u1F1A6", "/hdescender": "\u2C68", "/hdieresis": "\u1E27", "/hdot": "\u1E23", "/hdotaccent": "\u1E23", "/hdotbelow": "\u1E25", "/hdrsquare": "\u1F1A7", "/he": "\u05D4", "/he:hb": "\u05D4", "/headphone": "\u1F3A7", "/headstonegraveyard": "\u26FC", "/hearNoEvilMonkey": "\u1F649", "/heart": "\u2665", "/heartArrow": "\u1F498", "/heartDecoration": "\u1F49F", "/heartRibbon": "\u1F49D", "/heartTipOnTheLeft": "\u1F394", "/heartblack": "\u2665", "/heartsuitblack": "\u2665", "/heartsuitwhite": "\u2661", "/heartwhite": "\u2661", "/heavyDollarSign": "\u1F4B2", "/heavyLatinCross": "\u1F547", "/heavydbldashhorz": "\u254D", "/heavydbldashvert": "\u254F", "/heavydn": "\u257B", "/heavydnhorz": "\u2533", "/heavydnleft": "\u2513", "/heavydnright": "\u250F", "/heavyhorz": "\u2501", "/heavyleft": "\u2578", "/heavyleftlightright": "\u257E", "/heavyquaddashhorz": "\u2509", "/heavyquaddashvert": "\u250B", "/heavyright": "\u257A", "/heavytrpldashhorz": "\u2505", "/heavytrpldashvert": "\u2507", "/heavyup": "\u2579", "/heavyuphorz": "\u253B", "/heavyupleft": "\u251B", "/heavyuplightdn": "\u257F", "/heavyupright": "\u2517", "/heavyvert": "\u2503", "/heavyverthorz": "\u254B", "/heavyvertleft": "\u252B", "/heavyvertright": "\u2523", "/hecirclekatakana": "\u32EC", "/hedagesh": "\uFB34", "/hedageshhebrew": "\uFB34", "/hedinterlacedpentagramleft": "\u26E6", "/hedinterlacedpentagramright": "\u26E5", "/heh": "\u0647", "/heh.fina": "\uFEEA", "/heh.init": "\uFEEB", "/heh.init_alefmaksura.fina": "\uFC53", "/heh.init_jeem.fina": "\uFC51", "/heh.init_jeem.medi": "\uFCD7", "/heh.init_meem.fina": "\uFC52", "/heh.init_meem.medi": "\uFCD8", "/heh.init_meem.medi_jeem.medi": "\uFD93", "/heh.init_meem.medi_meem.medi": "\uFD94", "/heh.init_superscriptalef.medi": "\uFCD9", "/heh.init_yeh.fina": "\uFC54", "/heh.isol": "\uFEE9", "/heh.medi": "\uFEEC", "/hehaltonearabic": "\u06C1", "/heharabic": "\u0647", "/hehdoachashmee": "\u06BE", "/hehdoachashmee.fina": "\uFBAB", "/hehdoachashmee.init": "\uFBAC", "/hehdoachashmee.isol": "\uFBAA", "/hehdoachashmee.medi": "\uFBAD", "/hehebrew": "\u05D4", "/hehfinalaltonearabic": "\uFBA7", "/hehfinalalttwoarabic": "\uFEEA", "/hehfinalarabic": "\uFEEA", "/hehgoal": "\u06C1", "/hehgoal.fina": "\uFBA7", "/hehgoal.init": "\uFBA8", "/hehgoal.isol": "\uFBA6", "/hehgoal.medi": "\uFBA9", "/hehgoalhamza": "\u06C2", "/hehhamzaabovefinalarabic": "\uFBA5", "/hehhamzaaboveisolatedarabic": "\uFBA4", "/hehinitialaltonearabic": "\uFBA8", "/hehinitialarabic": "\uFEEB", "/hehinvertedV": "\u06FF", "/hehiragana": "\u3078", "/hehmedialaltonearabic": "\uFBA9", "/hehmedialarabic": "\uFEEC", "/hehyeh": "\u06C0", "/hehyeh.fina": "\uFBA5", "/hehyeh.isol": "\uFBA4", "/heiseierasquare": "\u337B", "/hekatakana": "\u30D8", "/hekatakanahalfwidth": "\uFF8D", "/hekutaarusquare": "\u3336", "/helicopter": "\u1F681", "/helm": "\u2388", "/helmetcrosswhite": "\u26D1", "/heng": "\uA727", "/henghook": "\u0267", "/herb": "\u1F33F", "/hermitianconjugatematrix": "\u22B9", "/herutusquare": "\u3339", "/het": "\u05D7", "/het:hb": "\u05D7", "/heta": "\u0371", "/hethebrew": "\u05D7", "/hewide:hb": "\uFB23", "/hewithmapiq:hb": "\uFB34", "/hfishhookturned": "\u02AE", "/hhalf": "\u2C76", "/hhook": "\u0266", "/hhooksuperior": "\u02B1", "/hhooksupmod": "\u02B1", "/hi-ressquare": "\u1F1A8", "/hibiscus": "\u1F33A", "/hicirclekatakana": "\u32EA", "/hieuhacirclekorean": "\u327B", "/hieuhaparenkorean": "\u321B", "/hieuhcirclekorean": "\u326D", "/hieuhkorean": "\u314E", "/hieuhparenkorean": "\u320D", "/high-heeledShoe": "\u1F460", "/highBrightness": "\u1F506", "/highSpeedTrain": "\u1F684", "/highSpeedTrainWithBulletNose": "\u1F685", "/highhamza": "\u0674", "/highideographiccircled": "\u32A4", "/highvoltage": "\u26A1", "/hihiragana": "\u3072", "/hikatakana": "\u30D2", "/hikatakanahalfwidth": "\uFF8B", "/hira:a": "\u3042", "/hira:asmall": "\u3041", "/hira:ba": "\u3070", "/hira:be": "\u3079", "/hira:bi": "\u3073", "/hira:bo": "\u307C", "/hira:bu": "\u3076", "/hira:da": "\u3060", "/hira:de": "\u3067", "/hira:di": "\u3062", "/hira:digraphyori": "\u309F", "/hira:do": "\u3069", "/hira:du": "\u3065", "/hira:e": "\u3048", "/hira:esmall": "\u3047", "/hira:ga": "\u304C", "/hira:ge": "\u3052", "/hira:gi": "\u304E", "/hira:go": "\u3054", "/hira:gu": "\u3050", "/hira:ha": "\u306F", "/hira:he": "\u3078", "/hira:hi": "\u3072", "/hira:ho": "\u307B", "/hira:hu": "\u3075", "/hira:i": "\u3044", "/hira:ismall": "\u3043", "/hira:iterationhiragana": "\u309D", "/hira:ka": "\u304B", "/hira:kasmall": "\u3095", "/hira:ke": "\u3051", "/hira:kesmall": "\u3096", "/hira:ki": "\u304D", "/hira:ko": "\u3053", "/hira:ku": "\u304F", "/hira:ma": "\u307E", "/hira:me": "\u3081", "/hira:mi": "\u307F", "/hira:mo": "\u3082", "/hira:mu": "\u3080", "/hira:n": "\u3093", "/hira:na": "\u306A", "/hira:ne": "\u306D", "/hira:ni": "\u306B", "/hira:no": "\u306E", "/hira:nu": "\u306C", "/hira:o": "\u304A", "/hira:osmall": "\u3049", "/hira:pa": "\u3071", "/hira:pe": "\u307A", "/hira:pi": "\u3074", "/hira:po": "\u307D", "/hira:pu": "\u3077", "/hira:ra": "\u3089", "/hira:re": "\u308C", "/hira:ri": "\u308A", "/hira:ro": "\u308D", "/hira:ru": "\u308B", "/hira:sa": "\u3055", "/hira:se": "\u305B", "/hira:semivoicedmarkkana": "\u309C", "/hira:semivoicedmarkkanacmb": "\u309A", "/hira:si": "\u3057", "/hira:so": "\u305D", "/hira:su": "\u3059", "/hira:ta": "\u305F", "/hira:te": "\u3066", "/hira:ti": "\u3061", "/hira:to": "\u3068", "/hira:tu": "\u3064", "/hira:tusmall": "\u3063", "/hira:u": "\u3046", "/hira:usmall": "\u3045", "/hira:voicediterationhiragana": "\u309E", "/hira:voicedmarkkana": "\u309B", "/hira:voicedmarkkanacmb": "\u3099", "/hira:vu": "\u3094", "/hira:wa": "\u308F", "/hira:wasmall": "\u308E", "/hira:we": "\u3091", "/hira:wi": "\u3090", "/hira:wo": "\u3092", "/hira:ya": "\u3084", "/hira:yasmall": "\u3083", "/hira:yo": "\u3088", "/hira:yosmall": "\u3087", "/hira:yu": "\u3086", "/hira:yusmall": "\u3085", "/hira:za": "\u3056", "/hira:ze": "\u305C", "/hira:zi": "\u3058", "/hira:zo": "\u305E", "/hira:zu": "\u305A", "/hiriq": "\u05B4", "/hiriq14": "\u05B4", "/hiriq21": "\u05B4", "/hiriq2d": "\u05B4", "/hiriq:hb": "\u05B4", "/hiriqhebrew": "\u05B4", "/hiriqnarrowhebrew": "\u05B4", "/hiriqquarterhebrew": "\u05B4", "/hiriqwidehebrew": "\u05B4", "/historicsite": "\u26EC", "/hlinebelow": "\u1E96", "/hmonospace": "\uFF48", "/hoarmenian": "\u0570", "/hocho": "\u1F52A", "/hocirclekatakana": "\u32ED", "/hohipthai": "\u0E2B", "/hohiragana": "\u307B", "/hokatakana": "\u30DB", "/hokatakanahalfwidth": "\uFF8E", "/holam": "\u05B9", "/holam19": "\u05B9", "/holam26": "\u05B9", "/holam32": "\u05B9", "/holam:hb": "\u05B9", "/holamHaser:hb": "\u05BA", "/holamhebrew": "\u05B9", "/holamnarrowhebrew": "\u05B9", "/holamquarterhebrew": "\u05B9", "/holamwidehebrew": "\u05B9", "/hole": "\u1F573", "/homotic": "\u223B", "/honeyPot": "\u1F36F", "/honeybee": "\u1F41D", "/honokhukthai": "\u0E2E", "/honsquare": "\u333F", "/hook": "\u2440", "/hookabovecomb": "\u0309", "/hookcmb": "\u0309", "/hookpalatalizedbelowcmb": "\u0321", "/hookretroflexbelowcmb": "\u0322", "/hoonsquare": "\u3342", "/hoorusquare": "\u3341", "/horicoptic": "\u03E9", "/horizontalTrafficLight": "\u1F6A5", "/horizontalbar": "\u2015", "/horizontalbarwhitearrowonpedestalup": "\u21EC", "/horizontalmalestroke": "\u26A9", "/horncmb": "\u031B", "/horse": "\u1F40E", "/horseFace": "\u1F434", "/horseRacing": "\u1F3C7", "/hospital": "\u1F3E5", "/hotDog": "\u1F32D", "/hotPepper": "\u1F336", "/hotbeverage": "\u2615", "/hotel": "\u1F3E8", "/hotsprings": "\u2668", "/hourglass": "\u231B", "/hourglassflowings": "\u23F3", "/house": "\u2302", "/houseBuilding": "\u1F3E0", "/houseBuildings": "\u1F3D8", "/houseGarden": "\u1F3E1", "/hpafullwidth": "\u3371", "/hpalatalhook": "\uA795", "/hparen": "\u24A3", "/hparenthesized": "\u24A3", "/hpfullwidth": "\u33CB", "/hryvnia": "\u20B4", "/hsuperior": "\u02B0", "/hsupmod": "\u02B0", "/hturned": "\u0265", "/htypeopencircuit": "\u238F", "/huaraddosquare": "\u3332", "/hucirclekatakana": "\u32EB", "/huhiragana": "\u3075", "/huiitosquare": "\u3333", "/hukatakana": "\u30D5", "/hukatakanahalfwidth": "\uFF8C", "/hundredPoints": "\u1F4AF", "/hundredthousandscmbcyr": "\u0488", "/hungarumlaut": "\u02DD", "/hungarumlautcmb": "\u030B", "/huransquare": "\u3335", "/hushedFace": "\u1F62F", "/hv": "\u0195", "/hwd:a": "\uFFC2", "/hwd:ae": "\uFFC3", "/hwd:blacksquare": "\uFFED", "/hwd:chieuch": "\uFFBA", "/hwd:cieuc": "\uFFB8", "/hwd:downwardsarrow": "\uFFEC", "/hwd:e": "\uFFC7", "/hwd:eo": "\uFFC6", "/hwd:eu": "\uFFDA", "/hwd:formslightvertical": "\uFFE8", "/hwd:hangulfiller": "\uFFA0", "/hwd:hieuh": "\uFFBE", "/hwd:i": "\uFFDC", "/hwd:ideographiccomma": "\uFF64", "/hwd:ideographicfullstop": "\uFF61", "/hwd:ieung": "\uFFB7", "/hwd:kata:a": "\uFF71", "/hwd:kata:asmall": "\uFF67", "/hwd:kata:e": "\uFF74", "/hwd:kata:esmall": "\uFF6A", "/hwd:kata:ha": "\uFF8A", "/hwd:kata:he": "\uFF8D", "/hwd:kata:hi": "\uFF8B", "/hwd:kata:ho": "\uFF8E", "/hwd:kata:hu": "\uFF8C", "/hwd:kata:i": "\uFF72", "/hwd:kata:ismall": "\uFF68", "/hwd:kata:ka": "\uFF76", "/hwd:kata:ke": "\uFF79", "/hwd:kata:ki": "\uFF77", "/hwd:kata:ko": "\uFF7A", "/hwd:kata:ku": "\uFF78", "/hwd:kata:ma": "\uFF8F", "/hwd:kata:me": "\uFF92", "/hwd:kata:mi": "\uFF90", "/hwd:kata:middledot": "\uFF65", "/hwd:kata:mo": "\uFF93", "/hwd:kata:mu": "\uFF91", "/hwd:kata:n": "\uFF9D", "/hwd:kata:na": "\uFF85", "/hwd:kata:ne": "\uFF88", "/hwd:kata:ni": "\uFF86", "/hwd:kata:no": "\uFF89", "/hwd:kata:nu": "\uFF87", "/hwd:kata:o": "\uFF75", "/hwd:kata:osmall": "\uFF6B", "/hwd:kata:prolongedkana": "\uFF70", "/hwd:kata:ra": "\uFF97", "/hwd:kata:re": "\uFF9A", "/hwd:kata:ri": "\uFF98", "/hwd:kata:ro": "\uFF9B", "/hwd:kata:ru": "\uFF99", "/hwd:kata:sa": "\uFF7B", "/hwd:kata:se": "\uFF7E", "/hwd:kata:semi-voiced": "\uFF9F", "/hwd:kata:si": "\uFF7C", "/hwd:kata:so": "\uFF7F", "/hwd:kata:su": "\uFF7D", "/hwd:kata:ta": "\uFF80", "/hwd:kata:te": "\uFF83", "/hwd:kata:ti": "\uFF81", "/hwd:kata:to": "\uFF84", "/hwd:kata:tu": "\uFF82", "/hwd:kata:tusmall": "\uFF6F", "/hwd:kata:u": "\uFF73", "/hwd:kata:usmall": "\uFF69", "/hwd:kata:voiced": "\uFF9E", "/hwd:kata:wa": "\uFF9C", "/hwd:kata:wo": "\uFF66", "/hwd:kata:ya": "\uFF94", "/hwd:kata:yasmall": "\uFF6C", "/hwd:kata:yo": "\uFF96", "/hwd:kata:yosmall": "\uFF6E", "/hwd:kata:yu": "\uFF95", "/hwd:kata:yusmall": "\uFF6D", "/hwd:khieukh": "\uFFBB", "/hwd:kiyeok": "\uFFA1", "/hwd:kiyeoksios": "\uFFA3", "/hwd:leftcornerbracket": "\uFF62", "/hwd:leftwardsarrow": "\uFFE9", "/hwd:mieum": "\uFFB1", "/hwd:nieun": "\uFFA4", "/hwd:nieuncieuc": "\uFFA5", "/hwd:nieunhieuh": "\uFFA6", "/hwd:o": "\uFFCC", "/hwd:oe": "\uFFCF", "/hwd:phieuph": "\uFFBD", "/hwd:pieup": "\uFFB2", "/hwd:pieupsios": "\uFFB4", "/hwd:rieul": "\uFFA9", "/hwd:rieulhieuh": "\uFFB0", "/hwd:rieulkiyeok": "\uFFAA", "/hwd:rieulmieum": "\uFFAB", "/hwd:rieulphieuph": "\uFFAF", "/hwd:rieulpieup": "\uFFAC", "/hwd:rieulsios": "\uFFAD", "/hwd:rieulthieuth": "\uFFAE", "/hwd:rightcornerbracket": "\uFF63", "/hwd:rightwardsarrow": "\uFFEB", "/hwd:sios": "\uFFB5", "/hwd:ssangcieuc": "\uFFB9", "/hwd:ssangkiyeok": "\uFFA2", "/hwd:ssangpieup": "\uFFB3", "/hwd:ssangsios": "\uFFB6", "/hwd:ssangtikeut": "\uFFA8", "/hwd:thieuth": "\uFFBC", "/hwd:tikeut": "\uFFA7", "/hwd:u": "\uFFD3", "/hwd:upwardsarrow": "\uFFEA", "/hwd:wa": "\uFFCD", "/hwd:wae": "\uFFCE", "/hwd:we": "\uFFD5", "/hwd:weo": "\uFFD4", "/hwd:whitecircle": "\uFFEE", "/hwd:wi": "\uFFD6", "/hwd:ya": "\uFFC4", "/hwd:yae": "\uFFC5", "/hwd:ye": "\uFFCB", "/hwd:yeo": "\uFFCA", "/hwd:yi": "\uFFDB", "/hwd:yo": "\uFFD2", "/hwd:yu": "\uFFD7", "/hyphen": "\u002D", "/hyphenationpoint": "\u2027", "/hyphenbullet": "\u2043", "/hyphendbl": "\u2E40", "/hyphendbloblique": "\u2E17", "/hyphendieresis": "\u2E1A", "/hypheninferior": "\uF6E5", "/hyphenminus": "\u002D", "/hyphenmonospace": "\uFF0D", "/hyphensmall": "\uFE63", "/hyphensoft": "\u00AD", "/hyphensuperior": "\uF6E6", "/hyphentwo": "\u2010", "/hypodiastole": "\u2E12", "/hysteresis": "\u238E", "/hzfullwidth": "\u3390", "/i": "\u0069", "/i.superior": "\u2071", "/iacute": "\u00ED", "/iacyrillic": "\u044F", "/iaepigraphic": "\uA7FE", "/ibengali": "\u0987", "/ibopomofo": "\u3127", "/ibreve": "\u012D", "/icaron": "\u01D0", "/iceCream": "\u1F368", "/iceHockeyStickAndPuck": "\u1F3D2", "/iceskate": "\u26F8", "/icircle": "\u24D8", "/icirclekatakana": "\u32D1", "/icircumflex": "\u00EE", "/icyr": "\u0438", "/icyrillic": "\u0456", "/idblgrave": "\u0209", "/idblstruckitalic": "\u2148", "/ideographearthcircle": "\u328F", "/ideographfirecircle": "\u328B", "/ideographicallianceparen": "\u323F", "/ideographiccallparen": "\u323A", "/ideographiccentrecircle": "\u32A5", "/ideographicclose": "\u3006", "/ideographiccomma": "\u3001", "/ideographiccommaleft": "\uFF64", "/ideographiccongratulationparen": "\u3237", "/ideographiccorrectcircle": "\u32A3", "/ideographicdepartingtonemark": "\u302C", "/ideographicearthparen": "\u322F", "/ideographicenteringtonemark": "\u302D", "/ideographicenterpriseparen": "\u323D", "/ideographicexcellentcircle": "\u329D", "/ideographicfestivalparen": "\u3240", "/ideographicfinancialcircle": "\u3296", "/ideographicfinancialparen": "\u3236", "/ideographicfireparen": "\u322B", "/ideographichalffillspace": "\u303F", "/ideographichaveparen": "\u3232", "/ideographichighcircle": "\u32A4", "/ideographiciterationmark": "\u3005", "/ideographiclaborcircle": "\u3298", "/ideographiclaborparen": "\u3238", "/ideographicleftcircle": "\u32A7", "/ideographicleveltonemark": "\u302A", "/ideographiclowcircle": "\u32A6", "/ideographicmedicinecircle": "\u32A9", "/ideographicmetalparen": "\u322E", "/ideographicmoonparen": "\u322A", "/ideographicnameparen": "\u3234", "/ideographicperiod": "\u3002", "/ideographicprintcircle": "\u329E", "/ideographicreachparen": "\u3243", "/ideographicrepresentparen": "\u3239", "/ideographicresourceparen": "\u323E", "/ideographicrightcircle": "\u32A8", "/ideographicrisingtonemark": "\u302B", "/ideographicsecretcircle": "\u3299", "/ideographicselfparen": "\u3242", "/ideographicsocietyparen": "\u3233", "/ideographicspace": "\u3000", "/ideographicspecialparen": "\u3235", "/ideographicstockparen": "\u3231", "/ideographicstudyparen": "\u323B", "/ideographicsunparen": "\u3230", "/ideographicsuperviseparen": "\u323C", "/ideographictelegraphlinefeedseparatorsymbol": "\u3037", "/ideographictelegraphsymbolforhoureight": "\u3360", "/ideographictelegraphsymbolforhoureighteen": "\u336A", "/ideographictelegraphsymbolforhoureleven": "\u3363", "/ideographictelegraphsymbolforhourfifteen": "\u3367", "/ideographictelegraphsymbolforhourfive": "\u335D", "/ideographictelegraphsymbolforhourfour": "\u335C", "/ideographictelegraphsymbolforhourfourteen": "\u3366", "/ideographictelegraphsymbolforhournine": "\u3361", "/ideographictelegraphsymbolforhournineteen": "\u336B", "/ideographictelegraphsymbolforhourone": "\u3359", "/ideographictelegraphsymbolforhourseven": "\u335F", "/ideographictelegraphsymbolforhourseventeen": "\u3369", "/ideographictelegraphsymbolforhoursix": "\u335E", "/ideographictelegraphsymbolforhoursixteen": "\u3368", "/ideographictelegraphsymbolforhourten": "\u3362", "/ideographictelegraphsymbolforhourthirteen": "\u3365", "/ideographictelegraphsymbolforhourthree": "\u335B", "/ideographictelegraphsymbolforhourtwelve": "\u3364", "/ideographictelegraphsymbolforhourtwenty": "\u336C", "/ideographictelegraphsymbolforhourtwentyfour": "\u3370", "/ideographictelegraphsymbolforhourtwentyone": "\u336D", "/ideographictelegraphsymbolforhourtwentythree": "\u336F", "/ideographictelegraphsymbolforhourtwentytwo": "\u336E", "/ideographictelegraphsymbolforhourtwo": "\u335A", "/ideographictelegraphsymbolforhourzero": "\u3358", "/ideographicvariationindicator": "\u303E", "/ideographicwaterparen": "\u322C", "/ideographicwoodparen": "\u322D", "/ideographiczero": "\u3007", "/ideographmetalcircle": "\u328E", "/ideographmooncircle": "\u328A", "/ideographnamecircle": "\u3294", "/ideographsuncircle": "\u3290", "/ideographwatercircle": "\u328C", "/ideographwoodcircle": "\u328D", "/ideva": "\u0907", "/idieresis": "\u00EF", "/idieresisacute": "\u1E2F", "/idieresiscyr": "\u04E5", "/idieresiscyrillic": "\u04E5", "/idotbelow": "\u1ECB", "/idsquare": "\u1F194", "/iebrevecyr": "\u04D7", "/iebrevecyrillic": "\u04D7", "/iecyr": "\u0435", "/iecyrillic": "\u0435", "/iegravecyr": "\u0450", "/iepigraphicsideways": "\uA7F7", "/ieungacirclekorean": "\u3275", "/ieungaparenkorean": "\u3215", "/ieungcirclekorean": "\u3267", "/ieungkorean": "\u3147", "/ieungparenkorean": "\u3207", "/ieungucirclekorean": "\u327E", "/igrave": "\u00EC", "/igravecyr": "\u045D", "/igravedbl": "\u0209", "/igujarati": "\u0A87", "/igurmukhi": "\u0A07", "/ihiragana": "\u3044", "/ihoi": "\u1EC9", "/ihookabove": "\u1EC9", "/iibengali": "\u0988", "/iicyrillic": "\u0438", "/iideva": "\u0908", "/iigujarati": "\u0A88", "/iigurmukhi": "\u0A08", "/iimatragurmukhi": "\u0A40", "/iinvertedbreve": "\u020B", "/iishortcyrillic": "\u0439", "/iivowelsignbengali": "\u09C0", "/iivowelsigndeva": "\u0940", "/iivowelsigngujarati": "\u0AC0", "/ij": "\u0133", "/ikatakana": "\u30A4", "/ikatakanahalfwidth": "\uFF72", "/ikawi": "\uA985", "/ikorean": "\u3163", "/ilde": "\u02DC", "/iluy:hb": "\u05AC", "/iluyhebrew": "\u05AC", "/imacron": "\u012B", "/imacroncyr": "\u04E3", "/imacroncyrillic": "\u04E3", "/image": "\u22B7", "/imageorapproximatelyequal": "\u2253", "/imatragurmukhi": "\u0A3F", "/imonospace": "\uFF49", "/imp": "\u1F47F", "/inboxTray": "\u1F4E5", "/incomingEnvelope": "\u1F4E8", "/increaseFontSize": "\u1F5DA", "/increment": "\u2206", "/indianrupee": "\u20B9", "/infinity": "\u221E", "/information": "\u2139", "/infullwidth": "\u33CC", "/inhibitarabicformshaping": "\u206C", "/inhibitsymmetricswapping": "\u206A", "/iniarmenian": "\u056B", "/iningusquare": "\u3304", "/inmationDeskPerson": "\u1F481", "/inputLatinCapitalLetters": "\u1F520", "/inputLatinLetters": "\u1F524", "/inputLatinSmallLetters": "\u1F521", "/inputNumbers": "\u1F522", "/inputS": "\u1F523", "/insertion": "\u2380", "/integral": "\u222B", "/integralbottom": "\u2321", "/integralbt": "\u2321", "/integralclockwise": "\u2231", "/integralcontour": "\u222E", "/integralcontouranticlockwise": "\u2233", "/integralcontourclockwise": "\u2232", "/integraldbl": "\u222C", "/integralex": "\uF8F5", "/integralextension": "\u23AE", "/integralsurface": "\u222F", "/integraltop": "\u2320", "/integraltp": "\u2320", "/integraltpl": "\u222D", "/integralvolume": "\u2230", "/intercalate": "\u22BA", "/interlinearanchor": "\uFFF9", "/interlinearseparator": "\uFFFA", "/interlinearterminator": "\uFFFB", "/interlockedfemalemale": "\u26A4", "/interrobang": "\u203D", "/interrobanginverted": "\u2E18", "/intersection": "\u2229", "/intersectionarray": "\u22C2", "/intersectiondbl": "\u22D2", "/intisquare": "\u3305", "/invbullet": "\u25D8", "/invcircle": "\u25D9", "/inverteddamma": "\u0657", "/invertedfork": "\u2443", "/invertedpentagram": "\u26E7", "/invertedundertie": "\u2054", "/invisibleplus": "\u2064", "/invisibleseparator": "\u2063", "/invisibletimes": "\u2062", "/invsmileface": "\u263B", "/iocyr": "\u0451", "/iocyrillic": "\u0451", "/iogonek": "\u012F", "/iota": "\u03B9", "/iotaacute": "\u1F77", "/iotaadscript": "\u1FBE", "/iotaasper": "\u1F31", "/iotaasperacute": "\u1F35", "/iotaaspergrave": "\u1F33", "/iotaaspertilde": "\u1F37", "/iotabreve": "\u1FD0", "/iotadieresis": "\u03CA", "/iotadieresisacute": "\u1FD3", "/iotadieresisgrave": "\u1FD2", "/iotadieresistilde": "\u1FD7", "/iotadieresistonos": "\u0390", "/iotafunc": "\u2373", "/iotagrave": "\u1F76", "/iotalatin": "\u0269", "/iotalenis": "\u1F30", "/iotalenisacute": "\u1F34", "/iotalenisgrave": "\u1F32", "/iotalenistilde": "\u1F36", "/iotasub": "\u037A", "/iotatilde": "\u1FD6", "/iotatonos": "\u03AF", "/iotaturned": "\u2129", "/iotaunderlinefunc": "\u2378", "/iotawithmacron": "\u1FD1", "/ipa:Ismall": "\u026A", "/ipa:alpha": "\u0251", "/ipa:ereversed": "\u0258", "/ipa:esh": "\u0283", "/ipa:gamma": "\u0263", "/ipa:glottalstop": "\u0294", "/ipa:gscript": "\u0261", "/ipa:iota": "\u0269", "/ipa:phi": "\u0278", "/ipa:rtail": "\u027D", "/ipa:schwa": "\u0259", "/ipa:upsilon": "\u028A", "/iparen": "\u24A4", "/iparenthesized": "\u24A4", "/irigurmukhi": "\u0A72", "/is": "\uA76D", "/isen-isenpada": "\uA9DF", "/ishortcyr": "\u0439", "/ishortsharptailcyr": "\u048B", "/ismallhiragana": "\u3043", "/ismallkatakana": "\u30A3", "/ismallkatakanahalfwidth": "\uFF68", "/issharbengali": "\u09FA", "/istroke": "\u0268", "/isuperior": "\uF6ED", "/itemideographiccircled": "\u32A0", "/iterationhiragana": "\u309D", "/iterationkatakana": "\u30FD", "/itilde": "\u0129", "/itildebelow": "\u1E2D", "/iubopomofo": "\u3129", "/iucyrillic": "\u044E", "/iufullwidth": "\u337A", "/iukrcyr": "\u0456", "/ivowelsignbengali": "\u09BF", "/ivowelsigndeva": "\u093F", "/ivowelsigngujarati": "\u0ABF", "/izakayaLantern": "\u1F3EE", "/izhitsacyr": "\u0475", "/izhitsacyrillic": "\u0475", "/izhitsadblgravecyrillic": "\u0477", "/izhitsagravedblcyr": "\u0477", "/j": "\u006A", "/j.inferior": "\u2C7C", "/jaarmenian": "\u0571", "/jabengali": "\u099C", "/jackOLantern": "\u1F383", "/jadeva": "\u091C", "/jagujarati": "\u0A9C", "/jagurmukhi": "\u0A1C", "/jamahaprana": "\uA999", "/januarytelegraph": "\u32C0", "/japaneseBeginner": "\u1F530", "/japaneseCastle": "\u1F3EF", "/japaneseDolls": "\u1F38E", "/japaneseGoblin": "\u1F47A", "/japaneseOgre": "\u1F479", "/japanesePostOffice": "\u1F3E3", "/japanesebank": "\u26FB", "/java:a": "\uA984", "/java:ai": "\uA98D", "/java:ba": "\uA9A7", "/java:ca": "\uA995", "/java:da": "\uA9A2", "/java:dda": "\uA99D", "/java:e": "\uA98C", "/java:eight": "\uA9D8", "/java:five": "\uA9D5", "/java:four": "\uA9D4", "/java:ga": "\uA992", "/java:ha": "\uA9B2", "/java:i": "\uA986", "/java:ii": "\uA987", "/java:ja": "\uA997", "/java:ka": "\uA98F", "/java:la": "\uA9AD", "/java:ma": "\uA9A9", "/java:na": "\uA9A4", "/java:nga": "\uA994", "/java:nine": "\uA9D9", "/java:nya": "\uA99A", "/java:o": "\uA98E", "/java:one": "\uA9D1", "/java:pa": "\uA9A5", "/java:ra": "\uA9AB", "/java:sa": "\uA9B1", "/java:seven": "\uA9D7", "/java:six": "\uA9D6", "/java:ta": "\uA9A0", "/java:three": "\uA9D3", "/java:tta": "\uA99B", "/java:two": "\uA9D2", "/java:u": "\uA988", "/java:wa": "\uA9AE", "/java:ya": "\uA9AA", "/java:zero": "\uA9D0", "/jbopomofo": "\u3110", "/jcaron": "\u01F0", "/jcircle": "\u24D9", "/jcircumflex": "\u0135", "/jcrossedtail": "\u029D", "/jdblstruckitalic": "\u2149", "/jdotlessstroke": "\u025F", "/jeans": "\u1F456", "/jecyr": "\u0458", "/jecyrillic": "\u0458", "/jeem": "\u062C", "/jeem.fina": "\uFE9E", "/jeem.init": "\uFE9F", "/jeem.init_alefmaksura.fina": "\uFD01", "/jeem.init_hah.fina": "\uFC15", "/jeem.init_hah.medi": "\uFCA7", "/jeem.init_meem.fina": "\uFC16", "/jeem.init_meem.medi": "\uFCA8", "/jeem.init_meem.medi_hah.medi": "\uFD59", "/jeem.init_yeh.fina": "\uFD02", "/jeem.isol": "\uFE9D", "/jeem.medi": "\uFEA0", "/jeem.medi_alefmaksura.fina": "\uFD1D", "/jeem.medi_hah.medi_alefmaksura.fina": "\uFDA6", "/jeem.medi_hah.medi_yeh.fina": "\uFDBE", "/jeem.medi_meem.medi_alefmaksura.fina": "\uFDA7", "/jeem.medi_meem.medi_hah.fina": "\uFD58", "/jeem.medi_meem.medi_yeh.fina": "\uFDA5", "/jeem.medi_yeh.fina": "\uFD1E", "/jeemabove": "\u06DA", "/jeemarabic": "\u062C", "/jeemfinalarabic": "\uFE9E", "/jeeminitialarabic": "\uFE9F", "/jeemmedialarabic": "\uFEA0", "/jeh": "\u0698", "/jeh.fina": "\uFB8B", "/jeh.isol": "\uFB8A", "/jeharabic": "\u0698", "/jehfinalarabic": "\uFB8B", "/jhabengali": "\u099D", "/jhadeva": "\u091D", "/jhagujarati": "\u0A9D", "/jhagurmukhi": "\u0A1D", "/jheharmenian": "\u057B", "/jis": "\u3004", "/jiterup": "\u2643", "/jmonospace": "\uFF4A", "/jotdiaeresisfunc": "\u2364", "/jotunderlinefunc": "\u235B", "/joystick": "\u1F579", "/jparen": "\u24A5", "/jparenthesized": "\u24A5", "/jstroke": "\u0249", "/jsuperior": "\u02B2", "/jsupmod": "\u02B2", "/jueuicircle": "\u327D", "/julytelegraph": "\u32C6", "/junetelegraph": "\u32C5", "/juno": "\u26B5", "/k": "\u006B", "/k.inferior": "\u2096", "/kaaba": "\u1F54B", "/kaaleutcyr": "\u051F", "/kabashkcyr": "\u04A1", "/kabashkircyrillic": "\u04A1", "/kabengali": "\u0995", "/kacirclekatakana": "\u32D5", "/kacute": "\u1E31", "/kacyr": "\u043A", "/kacyrillic": "\u043A", "/kadescendercyrillic": "\u049B", "/kadeva": "\u0915", "/kaf": "\u05DB", "/kaf.fina": "\uFEDA", "/kaf.init": "\uFEDB", "/kaf.init_alef.fina": "\uFC37", "/kaf.init_alefmaksura.fina": "\uFC3D", "/kaf.init_hah.fina": "\uFC39", "/kaf.init_hah.medi": "\uFCC5", "/kaf.init_jeem.fina": "\uFC38", "/kaf.init_jeem.medi": "\uFCC4", "/kaf.init_khah.fina": "\uFC3A", "/kaf.init_khah.medi": "\uFCC6", "/kaf.init_lam.fina": "\uFC3B", "/kaf.init_lam.medi": "\uFCC7", "/kaf.init_meem.fina": "\uFC3C", "/kaf.init_meem.medi": "\uFCC8", "/kaf.init_meem.medi_meem.medi": "\uFDC3", "/kaf.init_yeh.fina": "\uFC3E", "/kaf.isol": "\uFED9", "/kaf.medi": "\uFEDC", "/kaf.medi_alef.fina": "\uFC80", "/kaf.medi_alefmaksura.fina": "\uFC83", "/kaf.medi_lam.fina": "\uFC81", "/kaf.medi_lam.medi": "\uFCEB", "/kaf.medi_meem.fina": "\uFC82", "/kaf.medi_meem.medi": "\uFCEC", "/kaf.medi_meem.medi_meem.fina": "\uFDBB", "/kaf.medi_meem.medi_yeh.fina": "\uFDB7", "/kaf.medi_yeh.fina": "\uFC84", "/kaf:hb": "\u05DB", "/kafTwoDotsAbove": "\u077F", "/kafarabic": "\u0643", "/kafdagesh": "\uFB3B", "/kafdageshhebrew": "\uFB3B", "/kafdotabove": "\u06AC", "/kaffinalarabic": "\uFEDA", "/kafhebrew": "\u05DB", "/kafinitialarabic": "\uFEDB", "/kafmedialarabic": "\uFEDC", "/kafrafehebrew": "\uFB4D", "/kafring": "\u06AB", "/kafswash": "\u06AA", "/kafthreedotsbelow": "\u06AE", "/kafullwidth": "\u3384", "/kafwide:hb": "\uFB24", "/kafwithdagesh:hb": "\uFB3B", "/kafwithrafe:hb": "\uFB4D", "/kagujarati": "\u0A95", "/kagurmukhi": "\u0A15", "/kahiragana": "\u304B", "/kahookcyr": "\u04C4", "/kahookcyrillic": "\u04C4", "/kairisquare": "\u330B", "/kaisymbol": "\u03D7", "/kakatakana": "\u30AB", "/kakatakanahalfwidth": "\uFF76", "/kamurda": "\uA991", "/kappa": "\u03BA", "/kappa.math": "\u03F0", "/kappasymbolgreek": "\u03F0", "/kapyeounmieumkorean": "\u3171", "/kapyeounphieuphkorean": "\u3184", "/kapyeounpieupkorean": "\u3178", "/kapyeounssangpieupkorean": "\u3179", "/karattosquare": "\u330C", "/karoriisquare": "\u330D", "/kasasak": "\uA990", "/kashida": "\u0640", "/kashidaFina": "\uFE73", "/kashidaautoarabic": "\u0640", "/kashidaautonosidebearingarabic": "\u0640", "/kashmiriyeh": "\u0620", "/kasmallkatakana": "\u30F5", "/kasquare": "\u3384", "/kasra": "\u0650", "/kasraIsol": "\uFE7A", "/kasraMedi": "\uFE7B", "/kasraarabic": "\u0650", "/kasrasmall": "\u061A", "/kasratan": "\u064D", "/kasratanIsol": "\uFE74", "/kasratanarabic": "\u064D", "/kastrokecyr": "\u049F", "/kastrokecyrillic": "\u049F", "/kata:a": "\u30A2", "/kata:asmall": "\u30A1", "/kata:ba": "\u30D0", "/kata:be": "\u30D9", "/kata:bi": "\u30D3", "/kata:bo": "\u30DC", "/kata:bu": "\u30D6", "/kata:da": "\u30C0", "/kata:de": "\u30C7", "/kata:di": "\u30C2", "/kata:digraphkoto": "\u30FF", "/kata:do": "\u30C9", "/kata:doublehyphenkana": "\u30A0", "/kata:du": "\u30C5", "/kata:e": "\u30A8", "/kata:esmall": "\u30A7", "/kata:ga": "\u30AC", "/kata:ge": "\u30B2", "/kata:gi": "\u30AE", "/kata:go": "\u30B4", "/kata:gu": "\u30B0", "/kata:ha": "\u30CF", "/kata:he": "\u30D8", "/kata:hi": "\u30D2", "/kata:ho": "\u30DB", "/kata:hu": "\u30D5", "/kata:i": "\u30A4", "/kata:ismall": "\u30A3", "/kata:iteration": "\u30FD", "/kata:ka": "\u30AB", "/kata:kasmall": "\u30F5", "/kata:ke": "\u30B1", "/kata:kesmall": "\u30F6", "/kata:ki": "\u30AD", "/kata:ko": "\u30B3", "/kata:ku": "\u30AF", "/kata:ma": "\u30DE", "/kata:me": "\u30E1", "/kata:mi": "\u30DF", "/kata:middledot": "\u30FB", "/kata:mo": "\u30E2", "/kata:mu": "\u30E0", "/kata:n": "\u30F3", "/kata:na": "\u30CA", "/kata:ne": "\u30CD", "/kata:ni": "\u30CB", "/kata:no": "\u30CE", "/kata:nu": "\u30CC", "/kata:o": "\u30AA", "/kata:osmall": "\u30A9", "/kata:pa": "\u30D1", "/kata:pe": "\u30DA", "/kata:pi": "\u30D4", "/kata:po": "\u30DD", "/kata:prolongedkana": "\u30FC", "/kata:pu": "\u30D7", "/kata:ra": "\u30E9", "/kata:re": "\u30EC", "/kata:ri": "\u30EA", "/kata:ro": "\u30ED", "/kata:ru": "\u30EB", "/kata:sa": "\u30B5", "/kata:se": "\u30BB", "/kata:si": "\u30B7", "/kata:so": "\u30BD", "/kata:su": "\u30B9", "/kata:ta": "\u30BF", "/kata:te": "\u30C6", "/kata:ti": "\u30C1", "/kata:to": "\u30C8", "/kata:tu": "\u30C4", "/kata:tusmall": "\u30C3", "/kata:u": "\u30A6", "/kata:usmall": "\u30A5", "/kata:va": "\u30F7", "/kata:ve": "\u30F9", "/kata:vi": "\u30F8", "/kata:vo": "\u30FA", "/kata:voicediteration": "\u30FE", "/kata:vu": "\u30F4", "/kata:wa": "\u30EF", "/kata:wasmall": "\u30EE", "/kata:we": "\u30F1", "/kata:wi": "\u30F0", "/kata:wo": "\u30F2", "/kata:ya": "\u30E4", "/kata:yasmall": "\u30E3", "/kata:yo": "\u30E8", "/kata:yosmall": "\u30E7", "/kata:yu": "\u30E6", "/kata:yusmall": "\u30E5", "/kata:za": "\u30B6", "/kata:ze": "\u30BC", "/kata:zi": "\u30B8", "/kata:zo": "\u30BE", "/kata:zu": "\u30BA", "/katahiraprolongmarkhalfwidth": "\uFF70", "/katailcyr": "\u049B", "/kaverticalstrokecyr": "\u049D", "/kaverticalstrokecyrillic": "\u049D", "/kavykainvertedlow": "\u2E45", "/kavykalow": "\u2E47", "/kavykawithdotlow": "\u2E48", "/kavykawithkavykaaboveinvertedlow": "\u2E46", "/kbfullwidth": "\u3385", "/kbopomofo": "\u310E", "/kcalfullwidth": "\u3389", "/kcalsquare": "\u3389", "/kcaron": "\u01E9", "/kcedilla": "\u0137", "/kcircle": "\u24DA", "/kcommaaccent": "\u0137", "/kdescender": "\u2C6A", "/kdiagonalstroke": "\uA743", "/kdotbelow": "\u1E33", "/kecirclekatakana": "\u32D8", "/keesusquare": "\u331C", "/keharmenian": "\u0584", "/keheh": "\u06A9", "/keheh.fina": "\uFB8F", "/keheh.init": "\uFB90", "/keheh.isol": "\uFB8E", "/keheh.medi": "\uFB91", "/kehehDotAbove": "\u0762", "/kehehThreeDotsAbove": "\u0763", "/kehehThreeDotsUpBelow": "\u0764", "/kehehthreedotsbelow": "\u063C", "/kehehtwodotsabove": "\u063B", "/kehiragana": "\u3051", "/kekatakana": "\u30B1", "/kekatakanahalfwidth": "\uFF79", "/kelvin": "\u212A", "/kenarmenian": "\u056F", "/keretconsonant": "\uA9BD", "/kesmallkatakana": "\u30F6", "/key": "\u1F511", "/keyboardAndMouse": "\u1F5A6", "/keycapTen": "\u1F51F", "/kgfullwidth": "\u338F", "/kgreenlandic": "\u0138", "/khabengali": "\u0996", "/khacyrillic": "\u0445", "/khadeva": "\u0916", "/khagujarati": "\u0A96", "/khagurmukhi": "\u0A16", "/khah": "\u062E", "/khah.fina": "\uFEA6", "/khah.init": "\uFEA7", "/khah.init_alefmaksura.fina": "\uFD03", "/khah.init_hah.fina": "\uFC1A", "/khah.init_jeem.fina": "\uFC19", "/khah.init_jeem.medi": "\uFCAB", "/khah.init_meem.fina": "\uFC1B", "/khah.init_meem.medi": "\uFCAC", "/khah.init_yeh.fina": "\uFD04", "/khah.isol": "\uFEA5", "/khah.medi": "\uFEA8", "/khah.medi_alefmaksura.fina": "\uFD1F", "/khah.medi_yeh.fina": "\uFD20", "/khaharabic": "\u062E", "/khahfinalarabic": "\uFEA6", "/khahinitialarabic": "\uFEA7", "/khahmedialarabic": "\uFEA8", "/kheicoptic": "\u03E7", "/khhadeva": "\u0959", "/khhagurmukhi": "\u0A59", "/khieukhacirclekorean": "\u3278", "/khieukhaparenkorean": "\u3218", "/khieukhcirclekorean": "\u326A", "/khieukhkorean": "\u314B", "/khieukhparenkorean": "\u320A", "/khokhaithai": "\u0E02", "/khokhonthai": "\u0E05", "/khokhuatthai": "\u0E03", "/khokhwaithai": "\u0E04", "/khomutthai": "\u0E5B", "/khook": "\u0199", "/khorakhangthai": "\u0E06", "/khzfullwidth": "\u3391", "/khzsquare": "\u3391", "/kicirclekatakana": "\u32D6", "/kihiragana": "\u304D", "/kikatakana": "\u30AD", "/kikatakanahalfwidth": "\uFF77", "/kimono": "\u1F458", "/kindergartenideographiccircled": "\u3245", "/kingblack": "\u265A", "/kingwhite": "\u2654", "/kip": "\u20AD", "/kiroguramusquare": "\u3315", "/kiromeetorusquare": "\u3316", "/kirosquare": "\u3314", "/kirowattosquare": "\u3317", "/kiss": "\u1F48F", "/kissMark": "\u1F48B", "/kissingCatFaceWithClosedEyes": "\u1F63D", "/kissingFace": "\u1F617", "/kissingFaceWithClosedEyes": "\u1F61A", "/kissingFaceWithSmilingEyes": "\u1F619", "/kiyeokacirclekorean": "\u326E", "/kiyeokaparenkorean": "\u320E", "/kiyeokcirclekorean": "\u3260", "/kiyeokkorean": "\u3131", "/kiyeokparenkorean": "\u3200", "/kiyeoksioskorean": "\u3133", "/kjecyr": "\u045C", "/kjecyrillic": "\u045C", "/kkfullwidth": "\u33CD", "/klfullwidth": "\u3398", "/klinebelow": "\u1E35", "/klsquare": "\u3398", "/km2fullwidth": "\u33A2", "/km3fullwidth": "\u33A6", "/kmcapitalfullwidth": "\u33CE", "/kmcubedsquare": "\u33A6", "/kmfullwidth": "\u339E", "/kmonospace": "\uFF4B", "/kmsquaredsquare": "\u33A2", "/knda:a": "\u0C85", "/knda:aa": "\u0C86", "/knda:aasign": "\u0CBE", "/knda:ai": "\u0C90", "/knda:ailength": "\u0CD6", "/knda:aisign": "\u0CC8", "/knda:anusvara": "\u0C82", "/knda:au": "\u0C94", "/knda:ausign": "\u0CCC", "/knda:avagraha": "\u0CBD", "/knda:ba": "\u0CAC", "/knda:bha": "\u0CAD", "/knda:ca": "\u0C9A", "/knda:cha": "\u0C9B", "/knda:da": "\u0CA6", "/knda:dda": "\u0CA1", "/knda:ddha": "\u0CA2", "/knda:dha": "\u0CA7", "/knda:e": "\u0C8E", "/knda:ee": "\u0C8F", "/knda:eesign": "\u0CC7", "/knda:eight": "\u0CEE", "/knda:esign": "\u0CC6", "/knda:fa": "\u0CDE", "/knda:five": "\u0CEB", "/knda:four": "\u0CEA", "/knda:ga": "\u0C97", "/knda:gha": "\u0C98", "/knda:ha": "\u0CB9", "/knda:i": "\u0C87", "/knda:ii": "\u0C88", "/knda:iisign": "\u0CC0", "/knda:isign": "\u0CBF", "/knda:ja": "\u0C9C", "/knda:jha": "\u0C9D", "/knda:jihvamuliya": "\u0CF1", "/knda:ka": "\u0C95", "/knda:kha": "\u0C96", "/knda:la": "\u0CB2", "/knda:length": "\u0CD5", "/knda:lla": "\u0CB3", "/knda:llvocal": "\u0CE1", "/knda:llvocalsign": "\u0CE3", "/knda:lvocal": "\u0C8C", "/knda:lvocalsign": "\u0CE2", "/knda:ma": "\u0CAE", "/knda:na": "\u0CA8", "/knda:nga": "\u0C99", "/knda:nine": "\u0CEF", "/knda:nna": "\u0CA3", "/knda:nukta": "\u0CBC", "/knda:nya": "\u0C9E", "/knda:o": "\u0C92", "/knda:one": "\u0CE7", "/knda:oo": "\u0C93", "/knda:oosign": "\u0CCB", "/knda:osign": "\u0CCA", "/knda:pa": "\u0CAA", "/knda:pha": "\u0CAB", "/knda:ra": "\u0CB0", "/knda:rra": "\u0CB1", "/knda:rrvocal": "\u0CE0", "/knda:rrvocalsign": "\u0CC4", "/knda:rvocal": "\u0C8B", "/knda:rvocalsign": "\u0CC3", "/knda:sa": "\u0CB8", "/knda:seven": "\u0CED", "/knda:sha": "\u0CB6", "/knda:signcandrabindu": "\u0C81", "/knda:signspacingcandrabindu": "\u0C80", "/knda:six": "\u0CEC", "/knda:ssa": "\u0CB7", "/knda:ta": "\u0CA4", "/knda:tha": "\u0CA5", "/knda:three": "\u0CE9", "/knda:tta": "\u0C9F", "/knda:ttha": "\u0CA0", "/knda:two": "\u0CE8", "/knda:u": "\u0C89", "/knda:upadhmaniya": "\u0CF2", "/knda:usign": "\u0CC1", "/knda:uu": "\u0C8A", "/knda:uusign": "\u0CC2", "/knda:va": "\u0CB5", "/knda:virama": "\u0CCD", "/knda:visarga": "\u0C83", "/knda:ya": "\u0CAF", "/knda:zero": "\u0CE6", "/knightblack": "\u265E", "/knightwhite": "\u2658", "/ko:a": "\u314F", "/ko:ae": "\u3150", "/ko:aejungseong": "\u1162", "/ko:aeujungseong": "\u11A3", "/ko:ajungseong": "\u1161", "/ko:aojungseong": "\u1176", "/ko:araea": "\u318D", "/ko:araeae": "\u318E", "/ko:araeaeojungseong": "\u119F", "/ko:araeaijungseong": "\u11A1", "/ko:araeajungseong": "\u119E", "/ko:araeaujungseong": "\u11A0", "/ko:aujungseong": "\u1177", "/ko:ceongchieumchieuchchoseong": "\u1155", "/ko:ceongchieumcieucchoseong": "\u1150", "/ko:ceongchieumsioschoseong": "\u113E", "/ko:ceongchieumssangcieucchoseong": "\u1151", "/ko:ceongchieumssangsioschoseong": "\u113F", "/ko:chieuch": "\u314A", "/ko:chieuchchoseong": "\u110E", "/ko:chieuchhieuhchoseong": "\u1153", "/ko:chieuchjongseong": "\u11BE", "/ko:chieuchkhieukhchoseong": "\u1152", "/ko:chitueumchieuchchoseong": "\u1154", "/ko:chitueumcieucchoseong": "\u114E", "/ko:chitueumsioschoseong": "\u113C", "/ko:chitueumssangcieucchoseong": "\u114F", "/ko:chitueumssangsioschoseong": "\u113D", "/ko:cieuc": "\u3148", "/ko:cieucchoseong": "\u110C", "/ko:cieucieungchoseong": "\u114D", "/ko:cieucjongseong": "\u11BD", "/ko:e": "\u3154", "/ko:ejungseong": "\u1166", "/ko:eo": "\u3153", "/ko:eo_eujungseong": "\u117C", "/ko:eojungseong": "\u1165", "/ko:eoojungseong": "\u117A", "/ko:eoujungseong": "\u117B", "/ko:eu": "\u3161", "/ko:eueujungseong": "\u1196", "/ko:eujungseong": "\u1173", "/ko:euujungseong": "\u1195", "/ko:filler": "\u3164", "/ko:fillerchoseong": "\u115F", "/ko:fillerjungseong": "\u1160", "/ko:hieuh": "\u314E", "/ko:hieuhchoseong": "\u1112", "/ko:hieuhjongseong": "\u11C2", "/ko:hieuhmieumjongseong": "\u11F7", "/ko:hieuhnieunjongseong": "\u11F5", "/ko:hieuhpieupjongseong": "\u11F8", "/ko:hieuhrieuljongseong": "\u11F6", "/ko:i": "\u3163", "/ko:iajungseong": "\u1198", "/ko:iaraeajungseong": "\u119D", "/ko:ieujungseong": "\u119C", "/ko:ieung": "\u3147", "/ko:ieungchieuchchoseong": "\u1149", "/ko:ieungchoseong": "\u110B", "/ko:ieungcieucchoseong": "\u1148", "/ko:ieungjongseong": "\u11BC", "/ko:ieungkhieukhjongseong": "\u11EF", "/ko:ieungkiyeokchoseong": "\u1141", "/ko:ieungkiyeokjongseong": "\u11EC", "/ko:ieungmieumchoseong": "\u1143", "/ko:ieungpansioschoseong": "\u1146", "/ko:ieungphieuphchoseong": "\u114B", "/ko:ieungpieupchoseong": "\u1144", "/ko:ieungsioschoseong": "\u1145", "/ko:ieungssangkiyeokjongseong": "\u11ED", "/ko:ieungthieuthchoseong": "\u114A", "/ko:ieungtikeutchoseong": "\u1142", "/ko:ijungseong": "\u1175", "/ko:iojungseong": "\u119A", "/ko:iujungseong": "\u119B", "/ko:iyajungseong": "\u1199", "/ko:kapyeounmieum": "\u3171", "/ko:kapyeounmieumchoseong": "\u111D", "/ko:kapyeounmieumjongseong": "\u11E2", "/ko:kapyeounphieuph": "\u3184", "/ko:kapyeounphieuphchoseong": "\u1157", "/ko:kapyeounphieuphjongseong": "\u11F4", "/ko:kapyeounpieup": "\u3178", "/ko:kapyeounpieupchoseong": "\u112B", "/ko:kapyeounpieupjongseong": "\u11E6", "/ko:kapyeounrieulchoseong": "\u111B", "/ko:kapyeounssangpieup": "\u3179", "/ko:kapyeounssangpieupchoseong": "\u112C", "/ko:khieukh": "\u314B", "/ko:khieukhchoseong": "\u110F", "/ko:khieukhjongseong": "\u11BF", "/ko:kiyeok": "\u3131", "/ko:kiyeokchieuchjongseong": "\u11FC", "/ko:kiyeokchoseong": "\u1100", "/ko:kiyeokhieuhjongseong": "\u11FE", "/ko:kiyeokjongseong": "\u11A8", "/ko:kiyeokkhieukhjongseong": "\u11FD", "/ko:kiyeoknieunjongseong": "\u11FA", "/ko:kiyeokpieupjongseong": "\u11FB", "/ko:kiyeokrieuljongseong": "\u11C3", "/ko:kiyeoksios": "\u3133", "/ko:kiyeoksiosjongseong": "\u11AA", "/ko:kiyeoksioskiyeokjongseong": "\u11C4", "/ko:kiyeoktikeutchoseong": "\u115A", "/ko:mieum": "\u3141", "/ko:mieumchieuchjongseong": "\u11E0", "/ko:mieumchoseong": "\u1106", "/ko:mieumhieuhjongseong": "\u11E1", "/ko:mieumjongseong": "\u11B7", "/ko:mieumkiyeokjongseong": "\u11DA", "/ko:mieumpansios": "\u3170", "/ko:mieumpansiosjongseong": "\u11DF", "/ko:mieumpieup": "\u316E", "/ko:mieumpieupchoseong": "\u111C", "/ko:mieumpieupjongseong": "\u11DC", "/ko:mieumrieuljongseong": "\u11DB", "/ko:mieumsios": "\u316F", "/ko:mieumsiosjongseong": "\u11DD", "/ko:mieumssangsiosjongseong": "\u11DE", "/ko:nieun": "\u3134", "/ko:nieunchoseong": "\u1102", "/ko:nieuncieuc": "\u3135", "/ko:nieuncieucchoseong": "\u115C", "/ko:nieuncieucjongseong": "\u11AC", "/ko:nieunhieuh": "\u3136", "/ko:nieunhieuhchoseong": "\u115D", "/ko:nieunhieuhjongseong": "\u11AD", "/ko:nieunjongseong": "\u11AB", "/ko:nieunkiyeokchoseong": "\u1113", "/ko:nieunkiyeokjongseong": "\u11C5", "/ko:nieunpansios": "\u3168", "/ko:nieunpansiosjongseong": "\u11C8", "/ko:nieunpieupchoseong": "\u1116", "/ko:nieunsios": "\u3167", "/ko:nieunsioschoseong": "\u115B", "/ko:nieunsiosjongseong": "\u11C7", "/ko:nieunthieuthjongseong": "\u11C9", "/ko:nieuntikeut": "\u3166", "/ko:nieuntikeutchoseong": "\u1115", "/ko:nieuntikeutjongseong": "\u11C6", "/ko:o": "\u3157", "/ko:o_ejungseong": "\u1180", "/ko:o_eojungseong": "\u117F", "/ko:oe": "\u315A", "/ko:oejungseong": "\u116C", "/ko:ojungseong": "\u1169", "/ko:oojungseong": "\u1182", "/ko:oujungseong": "\u1183", "/ko:oyaejungseong": "\u11A7", "/ko:oyajungseong": "\u11A6", "/ko:oyejungseong": "\u1181", "/ko:pansios": "\u317F", "/ko:pansioschoseong": "\u1140", "/ko:pansiosjongseong": "\u11EB", "/ko:phieuph": "\u314D", "/ko:phieuphchoseong": "\u1111", "/ko:phieuphjongseong": "\u11C1", "/ko:phieuphpieupchoseong": "\u1156", "/ko:phieuphpieupjongseong": "\u11F3", "/ko:pieup": "\u3142", "/ko:pieupchieuchchoseong": "\u1128", "/ko:pieupchoseong": "\u1107", "/ko:pieupcieuc": "\u3176", "/ko:pieupcieucchoseong": "\u1127", "/ko:pieuphieuhjongseong": "\u11E5", "/ko:pieupjongseong": "\u11B8", "/ko:pieupkiyeok": "\u3172", "/ko:pieupkiyeokchoseong": "\u111E", "/ko:pieupnieunchoseong": "\u111F", "/ko:pieupphieuphchoseong": "\u112A", "/ko:pieupphieuphjongseong": "\u11E4", "/ko:pieuprieuljongseong": "\u11E3", "/ko:pieupsios": "\u3144", "/ko:pieupsioschoseong": "\u1121", "/ko:pieupsioscieucchoseong": "\u1126", "/ko:pieupsiosjongseong": "\u11B9", "/ko:pieupsioskiyeok": "\u3174", "/ko:pieupsioskiyeokchoseong": "\u1122", "/ko:pieupsiospieupchoseong": "\u1124", "/ko:pieupsiostikeut": "\u3175", "/ko:pieupsiostikeutchoseong": "\u1123", "/ko:pieupssangsioschoseong": "\u1125", "/ko:pieupthieuth": "\u3177", "/ko:pieupthieuthchoseong": "\u1129", "/ko:pieuptikeut": "\u3173", "/ko:pieuptikeutchoseong": "\u1120", "/ko:rieul": "\u3139", "/ko:rieulchoseong": "\u1105", "/ko:rieulhieuh": "\u3140", "/ko:rieulhieuhchoseong": "\u111A", "/ko:rieulhieuhjongseong": "\u11B6", "/ko:rieuljongseong": "\u11AF", "/ko:rieulkapyeounpieupjongseong": "\u11D5", "/ko:rieulkhieukhjongseong": "\u11D8", "/ko:rieulkiyeok": "\u313A", "/ko:rieulkiyeokjongseong": "\u11B0", "/ko:rieulkiyeoksios": "\u3169", "/ko:rieulkiyeoksiosjongseong": "\u11CC", "/ko:rieulmieum": "\u313B", "/ko:rieulmieumjongseong": "\u11B1", "/ko:rieulmieumkiyeokjongseong": "\u11D1", "/ko:rieulmieumsiosjongseong": "\u11D2", "/ko:rieulnieunchoseong": "\u1118", "/ko:rieulnieunjongseong": "\u11CD", "/ko:rieulpansios": "\u316C", "/ko:rieulpansiosjongseong": "\u11D7", "/ko:rieulphieuph": "\u313F", "/ko:rieulphieuphjongseong": "\u11B5", "/ko:rieulpieup": "\u313C", "/ko:rieulpieuphieuhjongseong": "\u11D4", "/ko:rieulpieupjongseong": "\u11B2", "/ko:rieulpieupsios": "\u316B", "/ko:rieulpieupsiosjongseong": "\u11D3", "/ko:rieulsios": "\u313D", "/ko:rieulsiosjongseong": "\u11B3", "/ko:rieulssangsiosjongseong": "\u11D6", "/ko:rieulthieuth": "\u313E", "/ko:rieulthieuthjongseong": "\u11B4", "/ko:rieultikeut": "\u316A", "/ko:rieultikeuthieuhjongseong": "\u11CF", "/ko:rieultikeutjongseong": "\u11CE", "/ko:rieulyeorinhieuh": "\u316D", "/ko:rieulyeorinhieuhjongseong": "\u11D9", "/ko:sios": "\u3145", "/ko:sioschieuchchoseong": "\u1137", "/ko:sioschoseong": "\u1109", "/ko:sioscieuc": "\u317E", "/ko:sioscieucchoseong": "\u1136", "/ko:sioshieuhchoseong": "\u113B", "/ko:siosieungchoseong": "\u1135", "/ko:siosjongseong": "\u11BA", "/ko:sioskhieukhchoseong": "\u1138", "/ko:sioskiyeok": "\u317A", "/ko:sioskiyeokchoseong": "\u112D", "/ko:sioskiyeokjongseong": "\u11E7", "/ko:siosmieumchoseong": "\u1131", "/ko:siosnieun": "\u317B", "/ko:siosnieunchoseong": "\u112E", "/ko:siosphieuphchoseong": "\u113A", "/ko:siospieup": "\u317D", "/ko:siospieupchoseong": "\u1132", "/ko:siospieupjongseong": "\u11EA", "/ko:siospieupkiyeokchoseong": "\u1133", "/ko:siosrieulchoseong": "\u1130", "/ko:siosrieuljongseong": "\u11E9", "/ko:siosssangsioschoseong": "\u1134", "/ko:siosthieuthchoseong": "\u1139", "/ko:siostikeut": "\u317C", "/ko:siostikeutchoseong": "\u112F", "/ko:siostikeutjongseong": "\u11E8", "/ko:ssangaraeajungseong": "\u11A2", "/ko:ssangcieuc": "\u3149", "/ko:ssangcieucchoseong": "\u110D", "/ko:ssanghieuh": "\u3185", "/ko:ssanghieuhchoseong": "\u1158", "/ko:ssangieung": "\u3180", "/ko:ssangieungchoseong": "\u1147", "/ko:ssangieungjongseong": "\u11EE", "/ko:ssangkiyeok": "\u3132", "/ko:ssangkiyeokchoseong": "\u1101", "/ko:ssangkiyeokjongseong": "\u11A9", "/ko:ssangnieun": "\u3165", "/ko:ssangnieunchoseong": "\u1114", "/ko:ssangnieunjongseong": "\u11FF", "/ko:ssangpieup": "\u3143", "/ko:ssangpieupchoseong": "\u1108", "/ko:ssangrieulchoseong": "\u1119", "/ko:ssangrieuljongseong": "\u11D0", "/ko:ssangsios": "\u3146", "/ko:ssangsioschoseong": "\u110A", "/ko:ssangsiosjongseong": "\u11BB", "/ko:ssangtikeut": "\u3138", "/ko:ssangtikeutchoseong": "\u1104", "/ko:thieuth": "\u314C", "/ko:thieuthchoseong": "\u1110", "/ko:thieuthjongseong": "\u11C0", "/ko:tikeut": "\u3137", "/ko:tikeutchoseong": "\u1103", "/ko:tikeutjongseong": "\u11AE", "/ko:tikeutkiyeokchoseong": "\u1117", "/ko:tikeutkiyeokjongseong": "\u11CA", "/ko:tikeutrieulchoseong": "\u115E", "/ko:tikeutrieuljongseong": "\u11CB", "/ko:u": "\u315C", "/ko:uaejungseong": "\u118A", "/ko:uajungseong": "\u1189", "/ko:ueo_eujungseong": "\u118B", "/ko:ujungseong": "\u116E", "/ko:uujungseong": "\u118D", "/ko:uyejungseong": "\u118C", "/ko:wa": "\u3158", "/ko:wae": "\u3159", "/ko:waejungseong": "\u116B", "/ko:wajungseong": "\u116A", "/ko:we": "\u315E", "/ko:wejungseong": "\u1170", "/ko:weo": "\u315D", "/ko:weojungseong": "\u116F", "/ko:wi": "\u315F", "/ko:wijungseong": "\u1171", "/ko:ya": "\u3151", "/ko:yae": "\u3152", "/ko:yaejungseong": "\u1164", "/ko:yajungseong": "\u1163", "/ko:yaojungseong": "\u1178", "/ko:yaujungseong": "\u11A4", "/ko:yayojungseong": "\u1179", "/ko:ye": "\u3156", "/ko:yejungseong": "\u1168", "/ko:yeo": "\u3155", "/ko:yeojungseong": "\u1167", "/ko:yeoojungseong": "\u117D", "/ko:yeorinhieuh": "\u3186", "/ko:yeorinhieuhchoseong": "\u1159", "/ko:yeorinhieuhjongseong": "\u11F9", "/ko:yeoujungseong": "\u117E", "/ko:yeoyajungseong": "\u11A5", "/ko:yesieung": "\u3181", "/ko:yesieungchoseong": "\u114C", "/ko:yesieungjongseong": "\u11F0", "/ko:yesieungpansios": "\u3183", "/ko:yesieungpansiosjongseong": "\u11F2", "/ko:yesieungsios": "\u3182", "/ko:yesieungsiosjongseong": "\u11F1", "/ko:yi": "\u3162", "/ko:yijungseong": "\u1174", "/ko:yiujungseong": "\u1197", "/ko:yo": "\u315B", "/ko:yoi": "\u3189", "/ko:yoijungseong": "\u1188", "/ko:yojungseong": "\u116D", "/ko:yoojungseong": "\u1187", "/ko:yoya": "\u3187", "/ko:yoyae": "\u3188", "/ko:yoyaejungseong": "\u1185", "/ko:yoyajungseong": "\u1184", "/ko:yoyeojungseong": "\u1186", "/ko:yu": "\u3160", "/ko:yuajungseong": "\u118E", "/ko:yuejungseong": "\u1190", "/ko:yueojungseong": "\u118F", "/ko:yui": "\u318C", "/ko:yuijungseong": "\u1194", "/ko:yujungseong": "\u1172", "/ko:yuujungseong": "\u1193", "/ko:yuye": "\u318B", "/ko:yuyejungseong": "\u1192", "/ko:yuyeo": "\u318A", "/ko:yuyeojungseong": "\u1191", "/koala": "\u1F428", "/kobliquestroke": "\uA7A3", "/kocirclekatakana": "\u32D9", "/kohiragana": "\u3053", "/kohmfullwidth": "\u33C0", "/kohmsquare": "\u33C0", "/kokaithai": "\u0E01", "/kokatakana": "\u30B3", "/kokatakanahalfwidth": "\uFF7A", "/kooposquare": "\u331E", "/koppa": "\u03DF", "/koppaarchaic": "\u03D9", "/koppacyr": "\u0481", "/koppacyrillic": "\u0481", "/koreanstandardsymbol": "\u327F", "/koroniscmb": "\u0343", "/korunasquare": "\u331D", "/kotoideographiccircled": "\u3247", "/kpafullwidth": "\u33AA", "/kparen": "\u24A6", "/kparenthesized": "\u24A6", "/kpasquare": "\u33AA", "/kra": "\u0138", "/ksicyr": "\u046F", "/ksicyrillic": "\u046F", "/kstroke": "\uA741", "/kstrokediagonalstroke": "\uA745", "/ktfullwidth": "\u33CF", "/ktsquare": "\u33CF", "/kturned": "\u029E", "/kucirclekatakana": "\u32D7", "/kuhiragana": "\u304F", "/kukatakana": "\u30AF", "/kukatakanahalfwidth": "\uFF78", "/kuroonesquare": "\u331B", "/kuruzeirosquare": "\u331A", "/kvfullwidth": "\u33B8", "/kvsquare": "\u33B8", "/kwfullwidth": "\u33BE", "/kwsquare": "\u33BE", "/kyuriisquare": "\u3312", "/l": "\u006C", "/l.inferior": "\u2097", "/label": "\u1F3F7", "/labengali": "\u09B2", "/laborideographiccircled": "\u3298", "/laborideographicparen": "\u3238", "/lacute": "\u013A", "/ladeva": "\u0932", "/ladyBeetle": "\u1F41E", "/lagujarati": "\u0AB2", "/lagurmukhi": "\u0A32", "/lakkhangyaothai": "\u0E45", "/lam": "\u0644", "/lam.fina": "\uFEDE", "/lam.init": "\uFEDF", "/lam.init_alef.fina": "\uFEFB", "/lam.init_alef.medi_hamzaabove.fina": "\uFEF7", "/lam.init_alef.medi_hamzabelow.fina": "\uFEF9", "/lam.init_alef.medi_maddaabove.fina": "\uFEF5", "/lam.init_alefmaksura.fina": "\uFC43", "/lam.init_hah.fina": "\uFC40", "/lam.init_hah.medi": "\uFCCA", "/lam.init_hah.medi_meem.medi": "\uFDB5", "/lam.init_heh.medi": "\uFCCD", "/lam.init_jeem.fina": "\uFC3F", "/lam.init_jeem.medi": "\uFCC9", "/lam.init_jeem.medi_jeem.medi": "\uFD83", "/lam.init_jeem.medi_meem.medi": "\uFDBA", "/lam.init_khah.fina": "\uFC41", "/lam.init_khah.medi": "\uFCCB", "/lam.init_khah.medi_meem.medi": "\uFD86", "/lam.init_meem.fina": "\uFC42", "/lam.init_meem.medi": "\uFCCC", "/lam.init_meem.medi_hah.medi": "\uFD88", "/lam.init_yeh.fina": "\uFC44", "/lam.isol": "\uFEDD", "/lam.medi": "\uFEE0", "/lam.medi_alef.fina": "\uFEFC", "/lam.medi_alef.medi_hamzaabove.fina": "\uFEF8", "/lam.medi_alef.medi_hamzabelow.fina": "\uFEFA", "/lam.medi_alef.medi_maddaabove.fina": "\uFEF6", "/lam.medi_alefmaksura.fina": "\uFC86", "/lam.medi_hah.medi_alefmaksura.fina": "\uFD82", "/lam.medi_hah.medi_meem.fina": "\uFD80", "/lam.medi_hah.medi_yeh.fina": "\uFD81", "/lam.medi_jeem.medi_jeem.fina": "\uFD84", "/lam.medi_jeem.medi_meem.fina": "\uFDBC", "/lam.medi_jeem.medi_yeh.fina": "\uFDAC", "/lam.medi_khah.medi_meem.fina": "\uFD85", "/lam.medi_meem.fina": "\uFC85", "/lam.medi_meem.medi": "\uFCED", "/lam.medi_meem.medi_hah.fina": "\uFD87", "/lam.medi_meem.medi_yeh.fina": "\uFDAD", "/lam.medi_yeh.fina": "\uFC87", "/lamBar": "\u076A", "/lamVabove": "\u06B5", "/lamalefabove": "\u06D9", "/lamaleffinalarabic": "\uFEFC", "/lamalefhamzaabovefinalarabic": "\uFEF8", "/lamalefhamzaaboveisolatedarabic": "\uFEF7", "/lamalefhamzabelowfinalarabic": "\uFEFA", "/lamalefhamzabelowisolatedarabic": "\uFEF9", "/lamalefisolatedarabic": "\uFEFB", "/lamalefmaddaabovefinalarabic": "\uFEF6", "/lamalefmaddaaboveisolatedarabic": "\uFEF5", "/lamarabic": "\u0644", "/lambda": "\u03BB", "/lambdastroke": "\u019B", "/lamdotabove": "\u06B6", "/lamed": "\u05DC", "/lamed:hb": "\u05DC", "/lameddagesh": "\uFB3C", "/lameddageshhebrew": "\uFB3C", "/lamedhebrew": "\u05DC", "/lamedholam": "\u05DC", "/lamedholamdagesh": "\u05DC", "/lamedholamdageshhebrew": "\u05DC", "/lamedholamhebrew": "\u05DC", "/lamedwide:hb": "\uFB25", "/lamedwithdagesh:hb": "\uFB3C", "/lamfinalarabic": "\uFEDE", "/lamhahinitialarabic": "\uFCCA", "/laminitialarabic": "\uFEDF", "/lamjeeminitialarabic": "\uFCC9", "/lamkhahinitialarabic": "\uFCCB", "/lamlamhehisolatedarabic": "\uFDF2", "/lammedialarabic": "\uFEE0", "/lammeemhahinitialarabic": "\uFD88", "/lammeeminitialarabic": "\uFCCC", "/lammeemjeeminitialarabic": "\uFEDF", "/lammeemkhahinitialarabic": "\uFEDF", "/lamthreedotsabove": "\u06B7", "/lamthreedotsbelow": "\u06B8", "/lanemergeleftblack": "\u26D8", "/lanemergeleftwhite": "\u26D9", "/largeBlueCircle": "\u1F535", "/largeBlueDiamond": "\u1F537", "/largeOrangeDiamond": "\u1F536", "/largeRedCircle": "\u1F534", "/largecircle": "\u25EF", "/largetackdown": "\u27D9", "/largetackup": "\u27D8", "/lari": "\u20BE", "/lastQuarterMoon": "\u1F317", "/lastQuarterMoonFace": "\u1F31C", "/lastquartermoon": "\u263E", "/layar": "\uA982", "/lazysinverted": "\u223E", "/lbar": "\u019A", "/lbbar": "\u2114", "/lbelt": "\u026C", "/lbeltretroflex": "\uA78E", "/lbopomofo": "\u310C", "/lbroken": "\uA747", "/lcaron": "\u013E", "/lcedilla": "\u013C", "/lcircle": "\u24DB", "/lcircumflexbelow": "\u1E3D", "/lcommaaccent": "\u013C", "/lcurl": "\u0234", "/ldblbar": "\u2C61", "/ldot": "\u0140", "/ldotaccent": "\u0140", "/ldotbelow": "\u1E37", "/ldotbelowmacron": "\u1E39", "/leafFlutteringInWind": "\u1F343", "/ledger": "\u1F4D2", "/left-pointingMagnifyingGlass": "\u1F50D", "/leftAngerBubble": "\u1F5EE", "/leftFiveEighthsBlock": "\u258B", "/leftHalfBlock": "\u258C", "/leftHandTelephoneReceiver": "\u1F57B", "/leftLuggage": "\u1F6C5", "/leftOneEighthBlock": "\u258F", "/leftOneQuarterBlock": "\u258E", "/leftSevenEighthsBlock": "\u2589", "/leftSpeechBubble": "\u1F5E8", "/leftThoughtBubble": "\u1F5EC", "/leftThreeEighthsBlock": "\u258D", "/leftThreeQuartersBlock": "\u258A", "/leftWritingHand": "\u1F58E", "/leftangleabovecmb": "\u031A", "/leftarrowoverrightarrow": "\u21C6", "/leftdnheavyrightuplight": "\u2545", "/leftharpoonoverrightharpoon": "\u21CB", "/leftheavyrightdnlight": "\u252D", "/leftheavyrightuplight": "\u2535", "/leftheavyrightvertlight": "\u253D", "/leftideographiccircled": "\u32A7", "/leftlightrightdnheavy": "\u2532", "/leftlightrightupheavy": "\u253A", "/leftlightrightvertheavy": "\u254A", "/lefttackbelowcmb": "\u0318", "/lefttorightembed": "\u202A", "/lefttorightisolate": "\u2066", "/lefttorightmark": "\u200E", "/lefttorightoverride": "\u202D", "/leftupheavyrightdnlight": "\u2543", "/lemon": "\u1F34B", "/lenis": "\u1FBF", "/lenisacute": "\u1FCE", "/lenisgrave": "\u1FCD", "/lenistilde": "\u1FCF", "/leo": "\u264C", "/leopard": "\u1F406", "/less": "\u003C", "/lessbutnotequal": "\u2268", "/lessbutnotequivalent": "\u22E6", "/lessdot": "\u22D6", "/lessequal": "\u2264", "/lessequalorgreater": "\u22DA", "/lessmonospace": "\uFF1C", "/lessorequivalent": "\u2272", "/lessorgreater": "\u2276", "/lessoverequal": "\u2266", "/lesssmall": "\uFE64", "/levelSlider": "\u1F39A", "/lezh": "\u026E", "/lfblock": "\u258C", "/lhacyr": "\u0515", "/lhookretroflex": "\u026D", "/libra": "\u264E", "/ligaturealeflamed:hb": "\uFB4F", "/ligatureoemod": "\uA7F9", "/lightCheckMark": "\u1F5F8", "/lightRail": "\u1F688", "/lightShade": "\u2591", "/lightarcdnleft": "\u256E", "/lightarcdnright": "\u256D", "/lightarcupleft": "\u256F", "/lightarcupright": "\u2570", "/lightdbldashhorz": "\u254C", "/lightdbldashvert": "\u254E", "/lightdiagcross": "\u2573", "/lightdiagupleftdnright": "\u2572", "/lightdiaguprightdnleft": "\u2571", "/lightdn": "\u2577", "/lightdnhorz": "\u252C", "/lightdnleft": "\u2510", "/lightdnright": "\u250C", "/lighthorz": "\u2500", "/lightleft": "\u2574", "/lightleftheavyright": "\u257C", "/lightning": "\u2607", "/lightningMood": "\u1F5F2", "/lightningMoodBubble": "\u1F5F1", "/lightquaddashhorz": "\u2508", "/lightquaddashvert": "\u250A", "/lightright": "\u2576", "/lighttrpldashhorz": "\u2504", "/lighttrpldashvert": "\u2506", "/lightup": "\u2575", "/lightupheavydn": "\u257D", "/lightuphorz": "\u2534", "/lightupleft": "\u2518", "/lightupright": "\u2514", "/lightvert": "\u2502", "/lightverthorz": "\u253C", "/lightvertleft": "\u2524", "/lightvertright": "\u251C", "/lineextensionhorizontal": "\u23AF", "/lineextensionvertical": "\u23D0", "/linemiddledotvertical": "\u237F", "/lineseparator": "\u2028", "/lingsapada": "\uA9C8", "/link": "\u1F517", "/linkedPaperclips": "\u1F587", "/lips": "\u1F5E2", "/lipstick": "\u1F484", "/lira": "\u20A4", "/litre": "\u2113", "/livretournois": "\u20B6", "/liwnarmenian": "\u056C", "/lj": "\u01C9", "/ljecyr": "\u0459", "/ljecyrillic": "\u0459", "/ljekomicyr": "\u0509", "/ll": "\uF6C0", "/lladeva": "\u0933", "/llagujarati": "\u0AB3", "/llinebelow": "\u1E3B", "/llladeva": "\u0934", "/llvocalicbengali": "\u09E1", "/llvocalicdeva": "\u0961", "/llvocalicvowelsignbengali": "\u09E3", "/llvocalicvowelsigndeva": "\u0963", "/llwelsh": "\u1EFB", "/lmacrondot": "\u1E39", "/lmfullwidth": "\u33D0", "/lmiddletilde": "\u026B", "/lmonospace": "\uFF4C", "/lmsquare": "\u33D0", "/lnfullwidth": "\u33D1", "/lochulathai": "\u0E2C", "/lock": "\u1F512", "/lockInkPen": "\u1F50F", "/logfullwidth": "\u33D2", "/logicaland": "\u2227", "/logicalandarray": "\u22C0", "/logicalnot": "\u00AC", "/logicalnotreversed": "\u2310", "/logicalor": "\u2228", "/logicalorarray": "\u22C1", "/lolingthai": "\u0E25", "/lollipop": "\u1F36D", "/longdivision": "\u27CC", "/longovershortmetrical": "\u23D2", "/longovertwoshortsmetrical": "\u23D4", "/longs": "\u017F", "/longs_t": "\uFB05", "/longsdot": "\u1E9B", "/longswithdiagonalstroke": "\u1E9C", "/longswithhighstroke": "\u1E9D", "/longtackleft": "\u27DE", "/longtackright": "\u27DD", "/losslesssquare": "\u1F1A9", "/loudlyCryingFace": "\u1F62D", "/loveHotel": "\u1F3E9", "/loveLetter": "\u1F48C", "/lowBrightness": "\u1F505", "/lowasterisk": "\u204E", "/lowerFiveEighthsBlock": "\u2585", "/lowerHalfBlock": "\u2584", "/lowerLeftBallpointPen": "\u1F58A", "/lowerLeftCrayon": "\u1F58D", "/lowerLeftFountainPen": "\u1F58B", "/lowerLeftPaintbrush": "\u1F58C", "/lowerLeftPencil": "\u1F589", "/lowerOneEighthBlock": "\u2581", "/lowerOneQuarterBlock": "\u2582", "/lowerRightShadowedWhiteCircle": "\u1F53E", "/lowerSevenEighthsBlock": "\u2587", "/lowerThreeEighthsBlock": "\u2583", "/lowerThreeQuartersBlock": "\u2586", "/lowercornerdotright": "\u27D3", "/lowerhalfcircle": "\u25E1", "/lowerhalfcircleinversewhite": "\u25DB", "/lowerquadrantcirculararcleft": "\u25DF", "/lowerquadrantcirculararcright": "\u25DE", "/lowertriangleleft": "\u25FA", "/lowertriangleleftblack": "\u25E3", "/lowertriangleright": "\u25FF", "/lowertrianglerightblack": "\u25E2", "/lowideographiccircled": "\u32A6", "/lowlinecenterline": "\uFE4E", "/lowlinecmb": "\u0332", "/lowlinedashed": "\uFE4D", "/lownumeralsign": "\u0375", "/lowquotedblprime": "\u301F", "/lozenge": "\u25CA", "/lozengedividedbyrulehorizontal": "\u27E0", "/lozengesquare": "\u2311", "/lparen": "\u24A7", "/lparenthesized": "\u24A7", "/lretroflex": "\u026D", "/ls": "\u02AA", "/lslash": "\u0142", "/lsquare": "\u2113", "/lstroke": "\uA749", "/lsuperior": "\uF6EE", "/lsupmod": "\u02E1", "/lt:Alpha": "\u2C6D", "/lt:Alphaturned": "\u2C70", "/lt:Beta": "\uA7B4", "/lt:Chi": "\uA7B3", "/lt:Gamma": "\u0194", "/lt:Iota": "\u0196", "/lt:Omega": "\uA7B6", "/lt:Upsilon": "\u01B1", "/lt:beta": "\uA7B5", "/lt:delta": "\u1E9F", "/lt:omega": "\uA7B7", "/ltshade": "\u2591", "/lttr:bet": "\u2136", "/lttr:dalet": "\u2138", "/lttr:gimel": "\u2137", "/lttr:gscript": "\u210A", "/lturned": "\uA781", "/ltypeopencircuit": "\u2390", "/luhurpada": "\uA9C5", "/lum": "\uA772", "/lungsipada": "\uA9C9", "/luthai": "\u0E26", "/lvocalicbengali": "\u098C", "/lvocalicdeva": "\u090C", "/lvocalicvowelsignbengali": "\u09E2", "/lvocalicvowelsigndeva": "\u0962", "/lxfullwidth": "\u33D3", "/lxsquare": "\u33D3", "/lzed": "\u02AB", "/m": "\u006D", "/m.inferior": "\u2098", "/m2fullwidth": "\u33A1", "/m3fullwidth": "\u33A5", "/mabengali": "\u09AE", "/macirclekatakana": "\u32EE", "/macron": "\u00AF", "/macronbelowcmb": "\u0331", "/macroncmb": "\u0304", "/macronlowmod": "\u02CD", "/macronmod": "\u02C9", "/macronmonospace": "\uFFE3", "/macute": "\u1E3F", "/madda": "\u0653", "/maddaabove": "\u06E4", "/madeva": "\u092E", "/madyapada": "\uA9C4", "/mafullwidth": "\u3383", "/magujarati": "\u0AAE", "/magurmukhi": "\u0A2E", "/mahapakhhebrew": "\u05A4", "/mahapakhlefthebrew": "\u05A4", "/mahhasquare": "\u3345", "/mahiragana": "\u307E", "/mahpach:hb": "\u05A4", "/maichattawalowleftthai": "\uF895", "/maichattawalowrightthai": "\uF894", "/maichattawathai": "\u0E4B", "/maichattawaupperleftthai": "\uF893", "/maieklowleftthai": "\uF88C", "/maieklowrightthai": "\uF88B", "/maiekthai": "\u0E48", "/maiekupperleftthai": "\uF88A", "/maihanakatleftthai": "\uF884", "/maihanakatthai": "\u0E31", "/maikurosquare": "\u3343", "/mairusquare": "\u3344", "/maitaikhuleftthai": "\uF889", "/maitaikhuthai": "\u0E47", "/maitholowleftthai": "\uF88F", "/maitholowrightthai": "\uF88E", "/maithothai": "\u0E49", "/maithoupperleftthai": "\uF88D", "/maitrilowleftthai": "\uF892", "/maitrilowrightthai": "\uF891", "/maitrithai": "\u0E4A", "/maitriupperleftthai": "\uF890", "/maiyamokthai": "\u0E46", "/makatakana": "\u30DE", "/makatakanahalfwidth": "\uFF8F", "/male": "\u2642", "/malefemale": "\u26A5", "/maleideographiccircled": "\u329A", "/malestroke": "\u26A6", "/malestrokemalefemale": "\u26A7", "/man": "\u1F468", "/manAndWomanHoldingHands": "\u1F46B", "/manDancing": "\u1F57A", "/manGuaPiMao": "\u1F472", "/manInBusinessSuitLevitating": "\u1F574", "/manTurban": "\u1F473", "/manat": "\u20BC", "/mansShoe": "\u1F45E", "/mansyonsquare": "\u3347", "/mantelpieceClock": "\u1F570", "/mapleLeaf": "\u1F341", "/maplighthouse": "\u26EF", "/maqaf:hb": "\u05BE", "/maqafhebrew": "\u05BE", "/marchtelegraph": "\u32C2", "/mark": "\u061C", "/markerdottedraisedinterpolation": "\u2E07", "/markerdottedtransposition": "\u2E08", "/markerraisedinterpolation": "\u2E06", "/marknoonghunna": "\u0658", "/marksChapter": "\u1F545", "/marriage": "\u26AD", "/mars": "\u2642", "/marukusquare": "\u3346", "/masoraCircle:hb": "\u05AF", "/masoracirclehebrew": "\u05AF", "/masquare": "\u3383", "/masumark": "\u303C", "/math:bowtie": "\u22C8", "/math:cuberoot": "\u221B", "/math:fourthroot": "\u221C", "/maximize": "\u1F5D6", "/maytelegraph": "\u32C4", "/mbfullwidth": "\u3386", "/mbopomofo": "\u3107", "/mbsmallfullwidth": "\u33D4", "/mbsquare": "\u33D4", "/mcircle": "\u24DC", "/mcubedsquare": "\u33A5", "/mdot": "\u1E41", "/mdotaccent": "\u1E41", "/mdotbelow": "\u1E43", "/measuredangle": "\u2221", "/measuredby": "\u225E", "/meatOnBone": "\u1F356", "/mecirclekatakana": "\u32F1", "/medicineideographiccircled": "\u32A9", "/mediumShade": "\u2592", "/mediumcircleblack": "\u26AB", "/mediumcirclewhite": "\u26AA", "/mediummathematicalspace": "\u205F", "/mediumsmallcirclewhite": "\u26AC", "/meem": "\u0645", "/meem.fina": "\uFEE2", "/meem.init": "\uFEE3", "/meem.init_alefmaksura.fina": "\uFC49", "/meem.init_hah.fina": "\uFC46", "/meem.init_hah.medi": "\uFCCF", "/meem.init_hah.medi_jeem.medi": "\uFD89", "/meem.init_hah.medi_meem.medi": "\uFD8A", "/meem.init_jeem.fina": "\uFC45", "/meem.init_jeem.medi": "\uFCCE", "/meem.init_jeem.medi_hah.medi": "\uFD8C", "/meem.init_jeem.medi_khah.medi": "\uFD92", "/meem.init_jeem.medi_meem.medi": "\uFD8D", "/meem.init_khah.fina": "\uFC47", "/meem.init_khah.medi": "\uFCD0", "/meem.init_khah.medi_jeem.medi": "\uFD8E", "/meem.init_khah.medi_meem.medi": "\uFD8F", "/meem.init_meem.fina": "\uFC48", "/meem.init_meem.medi": "\uFCD1", "/meem.init_yeh.fina": "\uFC4A", "/meem.isol": "\uFEE1", "/meem.medi": "\uFEE4", "/meem.medi_alef.fina": "\uFC88", "/meem.medi_hah.medi_yeh.fina": "\uFD8B", "/meem.medi_jeem.medi_yeh.fina": "\uFDC0", "/meem.medi_khah.medi_yeh.fina": "\uFDB9", "/meem.medi_meem.fina": "\uFC89", "/meem.medi_meem.medi_yeh.fina": "\uFDB1", "/meemDotAbove": "\u0765", "/meemDotBelow": "\u0766", "/meemabove": "\u06E2", "/meemabove.init": "\u06D8", "/meemarabic": "\u0645", "/meembelow": "\u06ED", "/meemfinalarabic": "\uFEE2", "/meeminitialarabic": "\uFEE3", "/meemmedialarabic": "\uFEE4", "/meemmeeminitialarabic": "\uFCD1", "/meemmeemisolatedarabic": "\uFC48", "/meetorusquare": "\u334D", "/megasquare": "\u334B", "/megatonsquare": "\u334C", "/mehiragana": "\u3081", "/meizierasquare": "\u337E", "/mekatakana": "\u30E1", "/mekatakanahalfwidth": "\uFF92", "/melon": "\u1F348", "/mem": "\u05DE", "/mem:hb": "\u05DE", "/memdagesh": "\uFB3E", "/memdageshhebrew": "\uFB3E", "/memhebrew": "\u05DE", "/memo": "\u1F4DD", "/memwithdagesh:hb": "\uFB3E", "/menarmenian": "\u0574", "/menorahNineBranches": "\u1F54E", "/menpostSindhi": "\u06FE", "/mens": "\u1F6B9", "/mepigraphicinverted": "\uA7FD", "/mercha:hb": "\u05A5", "/merchaKefulah:hb": "\u05A6", "/mercury": "\u263F", "/merkhahebrew": "\u05A5", "/merkhakefulahebrew": "\u05A6", "/merkhakefulalefthebrew": "\u05A6", "/merkhalefthebrew": "\u05A5", "/metalideographiccircled": "\u328E", "/metalideographicparen": "\u322E", "/meteg:hb": "\u05BD", "/metro": "\u1F687", "/mgfullwidth": "\u338E", "/mhook": "\u0271", "/mhzfullwidth": "\u3392", "/mhzsquare": "\u3392", "/micirclekatakana": "\u32EF", "/microphone": "\u1F3A4", "/microscope": "\u1F52C", "/middledotkatakanahalfwidth": "\uFF65", "/middot": "\u00B7", "/mieumacirclekorean": "\u3272", "/mieumaparenkorean": "\u3212", "/mieumcirclekorean": "\u3264", "/mieumkorean": "\u3141", "/mieumpansioskorean": "\u3170", "/mieumparenkorean": "\u3204", "/mieumpieupkorean": "\u316E", "/mieumsioskorean": "\u316F", "/mihiragana": "\u307F", "/mikatakana": "\u30DF", "/mikatakanahalfwidth": "\uFF90", "/mikuronsquare": "\u3348", "/milfullwidth": "\u33D5", "/militaryMedal": "\u1F396", "/milkyWay": "\u1F30C", "/mill": "\u20A5", "/millionscmbcyr": "\u0489", "/millisecond": "\u2034", "/millisecondreversed": "\u2037", "/minibus": "\u1F690", "/minidisc": "\u1F4BD", "/minimize": "\u1F5D5", "/minus": "\u2212", "/minus.inferior": "\u208B", "/minus.superior": "\u207B", "/minusbelowcmb": "\u0320", "/minuscircle": "\u2296", "/minusmod": "\u02D7", "/minusplus": "\u2213", "/minussignmod": "\u02D7", "/minustilde": "\u2242", "/minute": "\u2032", "/minutereversed": "\u2035", "/miribaarusquare": "\u334A", "/mirisquare": "\u3349", "/misc:baby": "\u1F476", "/misc:bell": "\u1F514", "/misc:dash": "\u1F4A8", "/misc:decimalseparator": "\u2396", "/misc:diamondblack": "\u2666", "/misc:diamondwhite": "\u2662", "/misc:ear": "\u1F442", "/misc:om": "\u1F549", "/misc:ring": "\u1F48D", "/misra": "\u060F", "/mlfullwidth": "\u3396", "/mlonglegturned": "\u0270", "/mlsquare": "\u3396", "/mlym:a": "\u0D05", "/mlym:aa": "\u0D06", "/mlym:aasign": "\u0D3E", "/mlym:ai": "\u0D10", "/mlym:aisign": "\u0D48", "/mlym:anusvarasign": "\u0D02", "/mlym:archaicii": "\u0D5F", "/mlym:au": "\u0D14", "/mlym:aulength": "\u0D57", "/mlym:ausign": "\u0D4C", "/mlym:avagrahasign": "\u0D3D", "/mlym:ba": "\u0D2C", "/mlym:bha": "\u0D2D", "/mlym:ca": "\u0D1A", "/mlym:candrabindusign": "\u0D01", "/mlym:cha": "\u0D1B", "/mlym:circularviramasign": "\u0D3C", "/mlym:combininganusvaraabovesign": "\u0D00", "/mlym:da": "\u0D26", "/mlym:date": "\u0D79", "/mlym:dda": "\u0D21", "/mlym:ddha": "\u0D22", "/mlym:dha": "\u0D27", "/mlym:dotreph": "\u0D4E", "/mlym:e": "\u0D0E", "/mlym:ee": "\u0D0F", "/mlym:eesign": "\u0D47", "/mlym:eight": "\u0D6E", "/mlym:esign": "\u0D46", "/mlym:five": "\u0D6B", "/mlym:four": "\u0D6A", "/mlym:ga": "\u0D17", "/mlym:gha": "\u0D18", "/mlym:ha": "\u0D39", "/mlym:i": "\u0D07", "/mlym:ii": "\u0D08", "/mlym:iisign": "\u0D40", "/mlym:isign": "\u0D3F", "/mlym:ja": "\u0D1C", "/mlym:jha": "\u0D1D", "/mlym:ka": "\u0D15", "/mlym:kchillu": "\u0D7F", "/mlym:kha": "\u0D16", "/mlym:la": "\u0D32", "/mlym:lchillu": "\u0D7D", "/mlym:lla": "\u0D33", "/mlym:llchillu": "\u0D7E", "/mlym:llla": "\u0D34", "/mlym:lllchillu": "\u0D56", "/mlym:llvocal": "\u0D61", "/mlym:llvocalsign": "\u0D63", "/mlym:lvocal": "\u0D0C", "/mlym:lvocalsign": "\u0D62", "/mlym:ma": "\u0D2E", "/mlym:mchillu": "\u0D54", "/mlym:na": "\u0D28", "/mlym:nchillu": "\u0D7B", "/mlym:nga": "\u0D19", "/mlym:nine": "\u0D6F", "/mlym:nna": "\u0D23", "/mlym:nnchillu": "\u0D7A", "/mlym:nnna": "\u0D29", "/mlym:nya": "\u0D1E", "/mlym:o": "\u0D12", "/mlym:one": "\u0D67", "/mlym:oneeighth": "\u0D77", "/mlym:onefifth": "\u0D5E", "/mlym:onefortieth": "\u0D59", "/mlym:onehalf": "\u0D74", "/mlym:onehundred": "\u0D71", "/mlym:oneone-hundred-and-sixtieth": "\u0D58", "/mlym:onequarter": "\u0D73", "/mlym:onesixteenth": "\u0D76", "/mlym:onetenth": "\u0D5C", "/mlym:onethousand": "\u0D72", "/mlym:onetwentieth": "\u0D5B", "/mlym:oo": "\u0D13", "/mlym:oosign": "\u0D4B", "/mlym:osign": "\u0D4A", "/mlym:pa": "\u0D2A", "/mlym:parasign": "\u0D4F", "/mlym:pha": "\u0D2B", "/mlym:ra": "\u0D30", "/mlym:rra": "\u0D31", "/mlym:rrchillu": "\u0D7C", "/mlym:rrvocal": "\u0D60", "/mlym:rrvocalsign": "\u0D44", "/mlym:rvocal": "\u0D0B", "/mlym:rvocalsign": "\u0D43", "/mlym:sa": "\u0D38", "/mlym:seven": "\u0D6D", "/mlym:sha": "\u0D36", "/mlym:six": "\u0D6C", "/mlym:ssa": "\u0D37", "/mlym:ta": "\u0D24", "/mlym:ten": "\u0D70", "/mlym:tha": "\u0D25", "/mlym:three": "\u0D69", "/mlym:threeeightieths": "\u0D5A", "/mlym:threequarters": "\u0D75", "/mlym:threesixteenths": "\u0D78", "/mlym:threetwentieths": "\u0D5D", "/mlym:tta": "\u0D1F", "/mlym:ttha": "\u0D20", "/mlym:ttta": "\u0D3A", "/mlym:two": "\u0D68", "/mlym:u": "\u0D09", "/mlym:usign": "\u0D41", "/mlym:uu": "\u0D0A", "/mlym:uusign": "\u0D42", "/mlym:va": "\u0D35", "/mlym:verticalbarviramasign": "\u0D3B", "/mlym:viramasign": "\u0D4D", "/mlym:visargasign": "\u0D03", "/mlym:ya": "\u0D2F", "/mlym:ychillu": "\u0D55", "/mlym:zero": "\u0D66", "/mm2fullwidth": "\u339F", "/mm3fullwidth": "\u33A3", "/mmcubedsquare": "\u33A3", "/mmfullwidth": "\u339C", "/mmonospace": "\uFF4D", "/mmsquaredsquare": "\u339F", "/mobilePhone": "\u1F4F1", "/mobilePhoneOff": "\u1F4F4", "/mobilePhoneRightwardsArrowAtLeft": "\u1F4F2", "/mocirclekatakana": "\u32F2", "/models": "\u22A7", "/mohiragana": "\u3082", "/mohmfullwidth": "\u33C1", "/mohmsquare": "\u33C1", "/mokatakana": "\u30E2", "/mokatakanahalfwidth": "\uFF93", "/molfullwidth": "\u33D6", "/molsquare": "\u33D6", "/momathai": "\u0E21", "/moneyBag": "\u1F4B0", "/moneyWings": "\u1F4B8", "/mong:a": "\u1820", "/mong:aaligali": "\u1887", "/mong:ahaligali": "\u1897", "/mong:ang": "\u1829", "/mong:angsibe": "\u1862", "/mong:angtodo": "\u184A", "/mong:anusvaraonealigali": "\u1880", "/mong:ba": "\u182A", "/mong:baludaaligali": "\u1885", "/mong:baludaaligalithree": "\u1886", "/mong:batodo": "\u184B", "/mong:bhamanchualigali": "\u18A8", "/mong:birga": "\u1800", "/mong:caaligali": "\u188B", "/mong:camanchualigali": "\u189C", "/mong:cha": "\u1834", "/mong:chasibe": "\u1871", "/mong:chatodo": "\u1852", "/mong:chi": "\u1842", "/mong:colon": "\u1804", "/mong:comma": "\u1802", "/mong:commamanchu": "\u1808", "/mong:cyamanchualigali": "\u18A3", "/mong:da": "\u1833", "/mong:daaligali": "\u1891", "/mong:dagalgaaligali": "\u18A9", "/mong:damarualigali": "\u1882", "/mong:dasibe": "\u1869", "/mong:datodo": "\u1851", "/mong:ddaaligali": "\u188E", "/mong:ddhamanchualigali": "\u189F", "/mong:dhamanchualigali": "\u18A1", "/mong:dzatodo": "\u185C", "/mong:e": "\u1821", "/mong:ee": "\u1827", "/mong:eight": "\u1818", "/mong:ellipsis": "\u1801", "/mong:esibe": "\u185D", "/mong:etodo": "\u1844", "/mong:fa": "\u1839", "/mong:famanchu": "\u1876", "/mong:fasibe": "\u186B", "/mong:five": "\u1815", "/mong:four": "\u1814", "/mong:fourdots": "\u1805", "/mong:freevariationselectorone": "\u180B", "/mong:freevariationselectorthree": "\u180D", "/mong:freevariationselectortwo": "\u180C", "/mong:ga": "\u182D", "/mong:gaasibe": "\u186C", "/mong:gaatodo": "\u1858", "/mong:gasibe": "\u1864", "/mong:gatodo": "\u184E", "/mong:ghamanchualigali": "\u189A", "/mong:haa": "\u183E", "/mong:haasibe": "\u186D", "/mong:haatodo": "\u1859", "/mong:hasibe": "\u1865", "/mong:i": "\u1822", "/mong:ialigali": "\u1888", "/mong:imanchu": "\u1873", "/mong:isibe": "\u185E", "/mong:itodo": "\u1845", "/mong:iysibe": "\u185F", "/mong:ja": "\u1835", "/mong:jasibe": "\u186A", "/mong:jatodo": "\u1853", "/mong:jhamanchualigali": "\u189D", "/mong:jiatodo": "\u185A", "/mong:ka": "\u183A", "/mong:kaaligali": "\u1889", "/mong:kamanchu": "\u1874", "/mong:kasibe": "\u1863", "/mong:katodo": "\u1857", "/mong:kha": "\u183B", "/mong:la": "\u182F", "/mong:lha": "\u1840", "/mong:lhamanchualigali": "\u18AA", "/mong:longvowelsigntodo": "\u1843", "/mong:ma": "\u182E", "/mong:matodo": "\u184F", "/mong:na": "\u1828", "/mong:ngaaligali": "\u188A", "/mong:ngamanchualigali": "\u189B", "/mong:niatodo": "\u185B", "/mong:nine": "\u1819", "/mong:nirugu": "\u180A", "/mong:nnaaligali": "\u188F", "/mong:o": "\u1823", "/mong:oe": "\u1825", "/mong:oetodo": "\u1848", "/mong:one": "\u1811", "/mong:otodo": "\u1846", "/mong:pa": "\u182B", "/mong:paaligali": "\u1892", "/mong:pasibe": "\u1866", "/mong:patodo": "\u184C", "/mong:period": "\u1803", "/mong:periodmanchu": "\u1809", "/mong:phaaligali": "\u1893", "/mong:qa": "\u182C", "/mong:qatodo": "\u184D", "/mong:ra": "\u1837", "/mong:raasibe": "\u1870", "/mong:ramanchu": "\u1875", "/mong:sa": "\u1830", "/mong:seven": "\u1817", "/mong:sha": "\u1831", "/mong:shasibe": "\u1867", "/mong:six": "\u1816", "/mong:softhyphentodo": "\u1806", "/mong:ssaaligali": "\u1894", "/mong:ssamanchualigali": "\u18A2", "/mong:syllableboundarymarkersibe": "\u1807", "/mong:ta": "\u1832", "/mong:taaligali": "\u1890", "/mong:tamanchualigali": "\u18A0", "/mong:tasibe": "\u1868", "/mong:tatodo": "\u1850", "/mong:tatodoaligali": "\u1898", "/mong:three": "\u1813", "/mong:tsa": "\u183C", "/mong:tsasibe": "\u186E", "/mong:tsatodo": "\u1854", "/mong:ttaaligali": "\u188C", "/mong:ttamanchualigali": "\u189E", "/mong:tthaaligali": "\u188D", "/mong:two": "\u1812", "/mong:u": "\u1824", "/mong:ualigalihalf": "\u18A6", "/mong:ubadamaaligali": "\u1883", "/mong:ubadamaaligaliinverted": "\u1884", "/mong:ue": "\u1826", "/mong:uesibe": "\u1860", "/mong:uetodo": "\u1849", "/mong:usibe": "\u1861", "/mong:utodo": "\u1847", "/mong:visargaonealigali": "\u1881", "/mong:vowelseparator": "\u180E", "/mong:wa": "\u1838", "/mong:watodo": "\u1856", "/mong:ya": "\u1836", "/mong:yaaligalihalf": "\u18A7", "/mong:yatodo": "\u1855", "/mong:za": "\u183D", "/mong:zaaligali": "\u1896", "/mong:zamanchualigali": "\u18A5", "/mong:zasibe": "\u186F", "/mong:zero": "\u1810", "/mong:zhaaligali": "\u1895", "/mong:zhamanchu": "\u1877", "/mong:zhamanchualigali": "\u18A4", "/mong:zhasibe": "\u1872", "/mong:zhatodoaligali": "\u1899", "/mong:zhi": "\u1841", "/mong:zra": "\u183F", "/monkey": "\u1F412", "/monkeyFace": "\u1F435", "/monogramyang": "\u268A", "/monogramyin": "\u268B", "/monorail": "\u1F69D", "/monostable": "\u238D", "/moodBubble": "\u1F5F0", "/moonViewingCeremony": "\u1F391", "/moonideographiccircled": "\u328A", "/moonideographicparen": "\u322A", "/moonlilithblack": "\u26B8", "/mosque": "\u1F54C", "/motorBoat": "\u1F6E5", "/motorScooter": "\u1F6F5", "/motorway": "\u1F6E3", "/mountFuji": "\u1F5FB", "/mountain": "\u26F0", "/mountainBicyclist": "\u1F6B5", "/mountainCableway": "\u1F6A0", "/mountainRailway": "\u1F69E", "/mouse": "\u1F401", "/mouseFace": "\u1F42D", "/mouth": "\u1F444", "/movers2fullwidth": "\u33A8", "/moversfullwidth": "\u33A7", "/moverssquare": "\u33A7", "/moverssquaredsquare": "\u33A8", "/movieCamera": "\u1F3A5", "/moyai": "\u1F5FF", "/mpafullwidth": "\u33AB", "/mparen": "\u24A8", "/mparenthesized": "\u24A8", "/mpasquare": "\u33AB", "/msfullwidth": "\u33B3", "/mssquare": "\u33B3", "/msuperior": "\uF6EF", "/mturned": "\u026F", "/mu": "\u00B5", "/mu.math": "\u00B5", "/mu1": "\u00B5", "/muafullwidth": "\u3382", "/muasquare": "\u3382", "/muchgreater": "\u226B", "/muchless": "\u226A", "/mucirclekatakana": "\u32F0", "/muffullwidth": "\u338C", "/mufsquare": "\u338C", "/mugfullwidth": "\u338D", "/mugreek": "\u03BC", "/mugsquare": "\u338D", "/muhiragana": "\u3080", "/mukatakana": "\u30E0", "/mukatakanahalfwidth": "\uFF91", "/mulfullwidth": "\u3395", "/mulsquare": "\u3395", "/multimap": "\u22B8", "/multimapleft": "\u27DC", "/multipleMusicalNotes": "\u1F3B6", "/multiply": "\u00D7", "/multiset": "\u228C", "/multisetmultiplication": "\u228D", "/multisetunion": "\u228E", "/mum": "\uA773", "/mumfullwidth": "\u339B", "/mumsquare": "\u339B", "/munach:hb": "\u05A3", "/munahhebrew": "\u05A3", "/munahlefthebrew": "\u05A3", "/musfullwidth": "\u33B2", "/mushroom": "\u1F344", "/musicalKeyboard": "\u1F3B9", "/musicalKeyboardJacks": "\u1F398", "/musicalNote": "\u1F3B5", "/musicalScore": "\u1F3BC", "/musicalnote": "\u266A", "/musicalnotedbl": "\u266B", "/musicflat": "\u266D", "/musicflatsign": "\u266D", "/musicnatural": "\u266E", "/musicsharp": "\u266F", "/musicsharpsign": "\u266F", "/mussquare": "\u33B2", "/muvfullwidth": "\u33B6", "/muvsquare": "\u33B6", "/muwfullwidth": "\u33BC", "/muwsquare": "\u33BC", "/mvfullwidth": "\u33B7", "/mvmegafullwidth": "\u33B9", "/mvmegasquare": "\u33B9", "/mvsquare": "\u33B7", "/mwfullwidth": "\u33BD", "/mwmegafullwidth": "\u33BF", "/mwmegasquare": "\u33BF", "/mwsquare": "\u33BD", "/n": "\u006E", "/n.inferior": "\u2099", "/n.superior": "\u207F", "/nabengali": "\u09A8", "/nabla": "\u2207", "/nacirclekatakana": "\u32E4", "/nacute": "\u0144", "/nadeva": "\u0928", "/nafullwidth": "\u3381", "/nagujarati": "\u0AA8", "/nagurmukhi": "\u0A28", "/nahiragana": "\u306A", "/nailPolish": "\u1F485", "/naira": "\u20A6", "/nakatakana": "\u30CA", "/nakatakanahalfwidth": "\uFF85", "/nameBadge": "\u1F4DB", "/nameideographiccircled": "\u3294", "/nameideographicparen": "\u3234", "/namurda": "\uA99F", "/nand": "\u22BC", "/nanosquare": "\u3328", "/napostrophe": "\u0149", "/narrownobreakspace": "\u202F", "/nasquare": "\u3381", "/nationalPark": "\u1F3DE", "/nationaldigitshapes": "\u206E", "/nbopomofo": "\u310B", "/nbspace": "\u00A0", "/ncaron": "\u0148", "/ncedilla": "\u0146", "/ncircle": "\u24DD", "/ncircumflexbelow": "\u1E4B", "/ncommaaccent": "\u0146", "/ncurl": "\u0235", "/ndescender": "\uA791", "/ndot": "\u1E45", "/ndotaccent": "\u1E45", "/ndotbelow": "\u1E47", "/necirclekatakana": "\u32E7", "/necktie": "\u1F454", "/negatedturnstiledblverticalbarright": "\u22AF", "/nehiragana": "\u306D", "/neirapproximatelynoractuallyequal": "\u2247", "/neirasersetnorequalup": "\u2289", "/neirasubsetnorequal": "\u2288", "/neirgreaternorequal": "\u2271", "/neirgreaternorequivalent": "\u2275", "/neirgreaternorless": "\u2279", "/neirlessnorequal": "\u2270", "/neirlessnorequivalent": "\u2274", "/neirlessnorgreater": "\u2278", "/nekatakana": "\u30CD", "/nekatakanahalfwidth": "\uFF88", "/neptune": "\u2646", "/neuter": "\u26B2", "/neutralFace": "\u1F610", "/newMoon": "\u1F311", "/newMoonFace": "\u1F31A", "/newsheqel": "\u20AA", "/newsheqelsign": "\u20AA", "/newspaper": "\u1F4F0", "/newsquare": "\u1F195", "/nextpage": "\u2398", "/nffullwidth": "\u338B", "/nfsquare": "\u338B", "/ng.fina": "\uFBD4", "/ng.init": "\uFBD5", "/ng.isol": "\uFBD3", "/ng.medi": "\uFBD6", "/ngabengali": "\u0999", "/ngadeva": "\u0919", "/ngagujarati": "\u0A99", "/ngagurmukhi": "\u0A19", "/ngalelet": "\uA98A", "/ngaleletraswadi": "\uA98B", "/ngoeh": "\u06B1", "/ngoeh.fina": "\uFB9B", "/ngoeh.init": "\uFB9C", "/ngoeh.isol": "\uFB9A", "/ngoeh.medi": "\uFB9D", "/ngonguthai": "\u0E07", "/ngrave": "\u01F9", "/ngsquare": "\u1F196", "/nhiragana": "\u3093", "/nhookleft": "\u0272", "/nhookretroflex": "\u0273", "/nicirclekatakana": "\u32E5", "/nieunacirclekorean": "\u326F", "/nieunaparenkorean": "\u320F", "/nieuncieuckorean": "\u3135", "/nieuncirclekorean": "\u3261", "/nieunhieuhkorean": "\u3136", "/nieunkorean": "\u3134", "/nieunpansioskorean": "\u3168", "/nieunparenkorean": "\u3201", "/nieunsioskorean": "\u3167", "/nieuntikeutkorean": "\u3166", "/nightStars": "\u1F303", "/nightideographiccircled": "\u32B0", "/nihiragana": "\u306B", "/nikatakana": "\u30CB", "/nikatakanahalfwidth": "\uFF86", "/nikhahitleftthai": "\uF899", "/nikhahitthai": "\u0E4D", "/nine": "\u0039", "/nine.inferior": "\u2089", "/nine.roman": "\u2168", "/nine.romansmall": "\u2178", "/nine.superior": "\u2079", "/ninearabic": "\u0669", "/ninebengali": "\u09EF", "/ninecircle": "\u2468", "/ninecircledbl": "\u24FD", "/ninecircleinversesansserif": "\u2792", "/ninecomma": "\u1F10A", "/ninedeva": "\u096F", "/ninefar": "\u06F9", "/ninegujarati": "\u0AEF", "/ninegurmukhi": "\u0A6F", "/ninehackarabic": "\u0669", "/ninehangzhou": "\u3029", "/nineideographiccircled": "\u3288", "/nineideographicparen": "\u3228", "/nineinferior": "\u2089", "/ninemonospace": "\uFF19", "/nineoldstyle": "\uF739", "/nineparen": "\u247C", "/nineparenthesized": "\u247C", "/nineperiod": "\u2490", "/ninepersian": "\u06F9", "/nineroman": "\u2178", "/ninesuperior": "\u2079", "/nineteencircle": "\u2472", "/nineteencircleblack": "\u24F3", "/nineteenparen": "\u2486", "/nineteenparenthesized": "\u2486", "/nineteenperiod": "\u249A", "/ninethai": "\u0E59", "/nj": "\u01CC", "/njecyr": "\u045A", "/njecyrillic": "\u045A", "/njekomicyr": "\u050B", "/nkatakana": "\u30F3", "/nkatakanahalfwidth": "\uFF9D", "/nlegrightlong": "\u019E", "/nlinebelow": "\u1E49", "/nlongrightleg": "\u019E", "/nmbr:oneeighth": "\u215B", "/nmbr:onefifth": "\u2155", "/nmbr:onetenth": "\u2152", "/nmfullwidth": "\u339A", "/nmonospace": "\uFF4E", "/nmsquare": "\u339A", "/nnabengali": "\u09A3", "/nnadeva": "\u0923", "/nnagujarati": "\u0AA3", "/nnagurmukhi": "\u0A23", "/nnnadeva": "\u0929", "/noBicycles": "\u1F6B3", "/noEntrySign": "\u1F6AB", "/noMobilePhones": "\u1F4F5", "/noOneUnderEighteen": "\u1F51E", "/noPedestrians": "\u1F6B7", "/noPiracy": "\u1F572", "/noSmoking": "\u1F6AD", "/nobliquestroke": "\uA7A5", "/nocirclekatakana": "\u32E8", "/nodeascending": "\u260A", "/nodedescending": "\u260B", "/noentry": "\u26D4", "/nohiragana": "\u306E", "/nokatakana": "\u30CE", "/nokatakanahalfwidth": "\uFF89", "/nominaldigitshapes": "\u206F", "/nonPotableWater": "\u1F6B1", "/nonbreakinghyphen": "\u2011", "/nonbreakingspace": "\u00A0", "/nonenthai": "\u0E13", "/nonuthai": "\u0E19", "/noon": "\u0646", "/noon.fina": "\uFEE6", "/noon.init": "\uFEE7", "/noon.init_alefmaksura.fina": "\uFC4F", "/noon.init_hah.fina": "\uFC4C", "/noon.init_hah.medi": "\uFCD3", "/noon.init_hah.medi_meem.medi": "\uFD95", "/noon.init_heh.medi": "\uFCD6", "/noon.init_jeem.fina": "\uFC4B", "/noon.init_jeem.medi": "\uFCD2", "/noon.init_jeem.medi_hah.medi": "\uFDB8", "/noon.init_jeem.medi_meem.medi": "\uFD98", "/noon.init_khah.fina": "\uFC4D", "/noon.init_khah.medi": "\uFCD4", "/noon.init_meem.fina": "\uFC4E", "/noon.init_meem.medi": "\uFCD5", "/noon.init_yeh.fina": "\uFC50", "/noon.isol": "\uFEE5", "/noon.medi": "\uFEE8", "/noon.medi_alefmaksura.fina": "\uFC8E", "/noon.medi_hah.medi_alefmaksura.fina": "\uFD96", "/noon.medi_hah.medi_yeh.fina": "\uFDB3", "/noon.medi_heh.medi": "\uFCEF", "/noon.medi_jeem.medi_alefmaksura.fina": "\uFD99", "/noon.medi_jeem.medi_hah.fina": "\uFDBD", "/noon.medi_jeem.medi_meem.fina": "\uFD97", "/noon.medi_jeem.medi_yeh.fina": "\uFDC7", "/noon.medi_meem.fina": "\uFC8C", "/noon.medi_meem.medi": "\uFCEE", "/noon.medi_meem.medi_alefmaksura.fina": "\uFD9B", "/noon.medi_meem.medi_yeh.fina": "\uFD9A", "/noon.medi_noon.fina": "\uFC8D", "/noon.medi_reh.fina": "\uFC8A", "/noon.medi_yeh.fina": "\uFC8F", "/noon.medi_zain.fina": "\uFC8B", "/noonSmallTah": "\u0768", "/noonSmallV": "\u0769", "/noonTwoDotsBelow": "\u0767", "/noonabove": "\u06E8", "/noonarabic": "\u0646", "/noondotbelow": "\u06B9", "/noonfinalarabic": "\uFEE6", "/noonghunna": "\u06BA", "/noonghunna.fina": "\uFB9F", "/noonghunna.isol": "\uFB9E", "/noonghunnaarabic": "\u06BA", "/noonghunnafinalarabic": "\uFB9F", "/noonhehinitialarabic": "\uFEE7", "/nooninitialarabic": "\uFEE7", "/noonjeeminitialarabic": "\uFCD2", "/noonjeemisolatedarabic": "\uFC4B", "/noonmedialarabic": "\uFEE8", "/noonmeeminitialarabic": "\uFCD5", "/noonmeemisolatedarabic": "\uFC4E", "/noonnoonfinalarabic": "\uFC8D", "/noonring": "\u06BC", "/noonthreedotsabove": "\u06BD", "/nor": "\u22BD", "/nordicmark": "\u20BB", "/normalfacrsemidirectproductleft": "\u22C9", "/normalfacrsemidirectproductright": "\u22CA", "/normalsubgroorequalup": "\u22B4", "/normalsubgroup": "\u22B2", "/northeastPointingAirplane": "\u1F6EA", "/nose": "\u1F443", "/notalmostequal": "\u2249", "/notasersetup": "\u2285", "/notasympticallyequal": "\u2244", "/notcheckmark": "\u237B", "/notchedLeftSemicircleThreeDots": "\u1F543", "/notchedRightSemicircleThreeDots": "\u1F544", "/notcontains": "\u220C", "/note": "\u1F5C8", "/notePad": "\u1F5CA", "/notePage": "\u1F5C9", "/notebook": "\u1F4D3", "/notebookDecorativeCover": "\u1F4D4", "/notelement": "\u2209", "/notelementof": "\u2209", "/notequal": "\u2260", "/notequivalent": "\u226D", "/notexistential": "\u2204", "/notgreater": "\u226F", "/notgreaternorequal": "\u2271", "/notgreaternorless": "\u2279", "/notidentical": "\u2262", "/notless": "\u226E", "/notlessnorequal": "\u2270", "/notnormalsubgroorequalup": "\u22EC", "/notnormalsubgroup": "\u22EA", "/notparallel": "\u2226", "/notprecedes": "\u2280", "/notsignturned": "\u2319", "/notsquareimageorequal": "\u22E2", "/notsquareoriginalorequal": "\u22E3", "/notsubset": "\u2284", "/notsucceeds": "\u2281", "/notsuperset": "\u2285", "/nottilde": "\u2241", "/nottosquare": "\u3329", "/nottrue": "\u22AD", "/novembertelegraph": "\u32CA", "/nowarmenian": "\u0576", "/nparen": "\u24A9", "/nparenthesized": "\u24A9", "/nretroflex": "\u0273", "/nsfullwidth": "\u33B1", "/nssquare": "\u33B1", "/nsuperior": "\u207F", "/ntilde": "\u00F1", "/nu": "\u03BD", "/nucirclekatakana": "\u32E6", "/nuhiragana": "\u306C", "/nukatakana": "\u30CC", "/nukatakanahalfwidth": "\uFF87", "/nuktabengali": "\u09BC", "/nuktadeva": "\u093C", "/nuktagujarati": "\u0ABC", "/nuktagurmukhi": "\u0A3C", "/num": "\uA774", "/numbermarkabove": "\u0605", "/numbersign": "\u0023", "/numbersignmonospace": "\uFF03", "/numbersignsmall": "\uFE5F", "/numeralsign": "\u0374", "/numeralsigngreek": "\u0374", "/numeralsignlowergreek": "\u0375", "/numero": "\u2116", "/nun": "\u05E0", "/nun:hb": "\u05E0", "/nunHafukha:hb": "\u05C6", "/nundagesh": "\uFB40", "/nundageshhebrew": "\uFB40", "/nunhebrew": "\u05E0", "/nunwithdagesh:hb": "\uFB40", "/nutAndBolt": "\u1F529", "/nvfullwidth": "\u33B5", "/nvsquare": "\u33B5", "/nwfullwidth": "\u33BB", "/nwsquare": "\u33BB", "/nyabengali": "\u099E", "/nyadeva": "\u091E", "/nyagujarati": "\u0A9E", "/nyagurmukhi": "\u0A1E", "/nyamurda": "\uA998", "/nyeh": "\u0683", "/nyeh.fina": "\uFB77", "/nyeh.init": "\uFB78", "/nyeh.isol": "\uFB76", "/nyeh.medi": "\uFB79", "/o": "\u006F", "/o.inferior": "\u2092", "/oacute": "\u00F3", "/oangthai": "\u0E2D", "/obarcyr": "\u04E9", "/obardieresiscyr": "\u04EB", "/obarred": "\u0275", "/obarredcyrillic": "\u04E9", "/obarreddieresiscyrillic": "\u04EB", "/obelosdotted": "\u2E13", "/obengali": "\u0993", "/obopomofo": "\u311B", "/obreve": "\u014F", "/observereye": "\u23FF", "/ocandradeva": "\u0911", "/ocandragujarati": "\u0A91", "/ocandravowelsigndeva": "\u0949", "/ocandravowelsigngujarati": "\u0AC9", "/ocaron": "\u01D2", "/ocircle": "\u24DE", "/ocirclekatakana": "\u32D4", "/ocircumflex": "\u00F4", "/ocircumflexacute": "\u1ED1", "/ocircumflexdotbelow": "\u1ED9", "/ocircumflexgrave": "\u1ED3", "/ocircumflexhoi": "\u1ED5", "/ocircumflexhookabove": "\u1ED5", "/ocircumflextilde": "\u1ED7", "/ocr:bowtie": "\u2445", "/ocr:dash": "\u2448", "/octagonalSign": "\u1F6D1", "/octobertelegraph": "\u32C9", "/octopus": "\u1F419", "/ocyr": "\u043E", "/ocyrillic": "\u043E", "/odblacute": "\u0151", "/odblgrave": "\u020D", "/oden": "\u1F362", "/odeva": "\u0913", "/odieresis": "\u00F6", "/odieresiscyr": "\u04E7", "/odieresiscyrillic": "\u04E7", "/odieresismacron": "\u022B", "/odot": "\u022F", "/odotbelow": "\u1ECD", "/odotmacron": "\u0231", "/oe": "\u0153", "/oe.fina": "\uFBDA", "/oe.isol": "\uFBD9", "/oekirghiz": "\u06C5", "/oekirghiz.fina": "\uFBE1", "/oekirghiz.isol": "\uFBE0", "/oekorean": "\u315A", "/officeBuilding": "\u1F3E2", "/ogonek": "\u02DB", "/ogonekcmb": "\u0328", "/ograve": "\u00F2", "/ogravedbl": "\u020D", "/ogujarati": "\u0A93", "/oharmenian": "\u0585", "/ohiragana": "\u304A", "/ohm": "\u2126", "/ohminverted": "\u2127", "/ohoi": "\u1ECF", "/ohookabove": "\u1ECF", "/ohorn": "\u01A1", "/ohornacute": "\u1EDB", "/ohorndotbelow": "\u1EE3", "/ohorngrave": "\u1EDD", "/ohornhoi": "\u1EDF", "/ohornhookabove": "\u1EDF", "/ohorntilde": "\u1EE1", "/ohungarumlaut": "\u0151", "/ohuparen": "\u321E", "/oi": "\u01A3", "/oilDrum": "\u1F6E2", "/oinvertedbreve": "\u020F", "/ojeonparen": "\u321D", "/okHandSign": "\u1F44C", "/okatakana": "\u30AA", "/okatakanahalfwidth": "\uFF75", "/okorean": "\u3157", "/oksquare": "\u1F197", "/oldKey": "\u1F5DD", "/oldPersonalComputer": "\u1F5B3", "/olderMan": "\u1F474", "/olderWoman": "\u1F475", "/ole:hb": "\u05AB", "/olehebrew": "\u05AB", "/oloop": "\uA74D", "/olowringinside": "\u2C7A", "/omacron": "\u014D", "/omacronacute": "\u1E53", "/omacrongrave": "\u1E51", "/omdeva": "\u0950", "/omega": "\u03C9", "/omega1": "\u03D6", "/omegaacute": "\u1F7D", "/omegaacuteiotasub": "\u1FF4", "/omegaasper": "\u1F61", "/omegaasperacute": "\u1F65", "/omegaasperacuteiotasub": "\u1FA5", "/omegaaspergrave": "\u1F63", "/omegaaspergraveiotasub": "\u1FA3", "/omegaasperiotasub": "\u1FA1", "/omegaaspertilde": "\u1F67", "/omegaaspertildeiotasub": "\u1FA7", "/omegaclosed": "\u0277", "/omegacyr": "\u0461", "/omegacyrillic": "\u0461", "/omegafunc": "\u2375", "/omegagrave": "\u1F7C", "/omegagraveiotasub": "\u1FF2", "/omegaiotasub": "\u1FF3", "/omegalatinclosed": "\u0277", "/omegalenis": "\u1F60", "/omegalenisacute": "\u1F64", "/omegalenisacuteiotasub": "\u1FA4", "/omegalenisgrave": "\u1F62", "/omegalenisgraveiotasub": "\u1FA2", "/omegalenisiotasub": "\u1FA0", "/omegalenistilde": "\u1F66", "/omegalenistildeiotasub": "\u1FA6", "/omegaroundcyr": "\u047B", "/omegaroundcyrillic": "\u047B", "/omegatilde": "\u1FF6", "/omegatildeiotasub": "\u1FF7", "/omegatitlocyr": "\u047D", "/omegatitlocyrillic": "\u047D", "/omegatonos": "\u03CE", "/omegaunderlinefunc": "\u2379", "/omgujarati": "\u0AD0", "/omicron": "\u03BF", "/omicronacute": "\u1F79", "/omicronasper": "\u1F41", "/omicronasperacute": "\u1F45", "/omicronaspergrave": "\u1F43", "/omicrongrave": "\u1F78", "/omicronlenis": "\u1F40", "/omicronlenisacute": "\u1F44", "/omicronlenisgrave": "\u1F42", "/omicrontonos": "\u03CC", "/omonospace": "\uFF4F", "/onExclamationMarkLeftRightArrowAbove": "\u1F51B", "/oncomingAutomobile": "\u1F698", "/oncomingBus": "\u1F68D", "/oncomingFireEngine": "\u1F6F1", "/oncomingPoliceCar": "\u1F694", "/oncomingTaxi": "\u1F696", "/one": "\u0031", "/one.inferior": "\u2081", "/one.roman": "\u2160", "/one.romansmall": "\u2170", "/oneButtonMouse": "\u1F5AF", "/onearabic": "\u0661", "/onebengali": "\u09E7", "/onecircle": "\u2460", "/onecircledbl": "\u24F5", "/onecircleinversesansserif": "\u278A", "/onecomma": "\u1F102", "/onedeva": "\u0967", "/onedotenleader": "\u2024", "/onedotovertwodots": "\u2E2B", "/oneeighth": "\u215B", "/onefar": "\u06F1", "/onefitted": "\uF6DC", "/onefraction": "\u215F", "/onegujarati": "\u0AE7", "/onegurmukhi": "\u0A67", "/onehackarabic": "\u0661", "/onehalf": "\u00BD", "/onehangzhou": "\u3021", "/onehundred.roman": "\u216D", "/onehundred.romansmall": "\u217D", "/onehundredthousand.roman": "\u2188", "/onehundredtwentypsquare": "\u1F1A4", "/oneideographiccircled": "\u3280", "/oneideographicparen": "\u3220", "/oneinferior": "\u2081", "/onemonospace": "\uFF11", "/oneninth": "\u2151", "/onenumeratorbengali": "\u09F4", "/oneoldstyle": "\uF731", "/oneparen": "\u2474", "/oneparenthesized": "\u2474", "/oneperiod": "\u2488", "/onepersian": "\u06F1", "/onequarter": "\u00BC", "/oneroman": "\u2170", "/oneseventh": "\u2150", "/onesixth": "\u2159", "/onesuperior": "\u00B9", "/onethai": "\u0E51", "/onethird": "\u2153", "/onethousand.roman": "\u216F", "/onethousand.romansmall": "\u217F", "/onethousandcd.roman": "\u2180", "/onsusquare": "\u3309", "/oo": "\uA74F", "/oogonek": "\u01EB", "/oogonekmacron": "\u01ED", "/oogurmukhi": "\u0A13", "/oomatragurmukhi": "\u0A4B", "/oomusquare": "\u330A", "/oopen": "\u0254", "/oparen": "\u24AA", "/oparenthesized": "\u24AA", "/openBook": "\u1F4D6", "/openFileFolder": "\u1F4C2", "/openFolder": "\u1F5C1", "/openHandsSign": "\u1F450", "/openLock": "\u1F513", "/openMailboxLoweredFlag": "\u1F4ED", "/openMailboxRaisedFlag": "\u1F4EC", "/openbullet": "\u25E6", "/openheadarrowleft": "\u21FD", "/openheadarrowleftright": "\u21FF", "/openheadarrowright": "\u21FE", "/opensubset": "\u27C3", "/opensuperset": "\u27C4", "/ophiuchus": "\u26CE", "/opposition": "\u260D", "/opticalDisc": "\u1F4BF", "/opticalDiscIcon": "\u1F5B8", "/option": "\u2325", "/orangeBook": "\u1F4D9", "/ordfeminine": "\u00AA", "/ordmasculine": "\u00BA", "/ordotinside": "\u27C7", "/original": "\u22B6", "/ornateleftparenthesis": "\uFD3E", "/ornaterightparenthesis": "\uFD3F", "/orthodoxcross": "\u2626", "/orthogonal": "\u221F", "/orya:a": "\u0B05", "/orya:aa": "\u0B06", "/orya:aasign": "\u0B3E", "/orya:ai": "\u0B10", "/orya:ailengthmark": "\u0B56", "/orya:aisign": "\u0B48", "/orya:anusvara": "\u0B02", "/orya:au": "\u0B14", "/orya:aulengthmark": "\u0B57", "/orya:ausign": "\u0B4C", "/orya:avagraha": "\u0B3D", "/orya:ba": "\u0B2C", "/orya:bha": "\u0B2D", "/orya:ca": "\u0B1A", "/orya:candrabindu": "\u0B01", "/orya:cha": "\u0B1B", "/orya:da": "\u0B26", "/orya:dda": "\u0B21", "/orya:ddha": "\u0B22", "/orya:dha": "\u0B27", "/orya:e": "\u0B0F", "/orya:eight": "\u0B6E", "/orya:esign": "\u0B47", "/orya:five": "\u0B6B", "/orya:four": "\u0B6A", "/orya:fractiononeeighth": "\u0B76", "/orya:fractiononehalf": "\u0B73", "/orya:fractiononequarter": "\u0B72", "/orya:fractiononesixteenth": "\u0B75", "/orya:fractionthreequarters": "\u0B74", "/orya:fractionthreesixteenths": "\u0B77", "/orya:ga": "\u0B17", "/orya:gha": "\u0B18", "/orya:ha": "\u0B39", "/orya:i": "\u0B07", "/orya:ii": "\u0B08", "/orya:iisign": "\u0B40", "/orya:isign": "\u0B3F", "/orya:isshar": "\u0B70", "/orya:ja": "\u0B1C", "/orya:jha": "\u0B1D", "/orya:ka": "\u0B15", "/orya:kha": "\u0B16", "/orya:la": "\u0B32", "/orya:lla": "\u0B33", "/orya:llvocal": "\u0B61", "/orya:llvocalsign": "\u0B63", "/orya:lvocal": "\u0B0C", "/orya:lvocalsign": "\u0B62", "/orya:ma": "\u0B2E", "/orya:na": "\u0B28", "/orya:nga": "\u0B19", "/orya:nine": "\u0B6F", "/orya:nna": "\u0B23", "/orya:nukta": "\u0B3C", "/orya:nya": "\u0B1E", "/orya:o": "\u0B13", "/orya:one": "\u0B67", "/orya:osign": "\u0B4B", "/orya:pa": "\u0B2A", "/orya:pha": "\u0B2B", "/orya:ra": "\u0B30", "/orya:rha": "\u0B5D", "/orya:rra": "\u0B5C", "/orya:rrvocal": "\u0B60", "/orya:rrvocalsign": "\u0B44", "/orya:rvocal": "\u0B0B", "/orya:rvocalsign": "\u0B43", "/orya:sa": "\u0B38", "/orya:seven": "\u0B6D", "/orya:sha": "\u0B36", "/orya:six": "\u0B6C", "/orya:ssa": "\u0B37", "/orya:ta": "\u0B24", "/orya:tha": "\u0B25", "/orya:three": "\u0B69", "/orya:tta": "\u0B1F", "/orya:ttha": "\u0B20", "/orya:two": "\u0B68", "/orya:u": "\u0B09", "/orya:usign": "\u0B41", "/orya:uu": "\u0B0A", "/orya:uusign": "\u0B42", "/orya:va": "\u0B35", "/orya:virama": "\u0B4D", "/orya:visarga": "\u0B03", "/orya:wa": "\u0B71", "/orya:ya": "\u0B2F", "/orya:yya": "\u0B5F", "/orya:zero": "\u0B66", "/oscript": "\u2134", "/oshortdeva": "\u0912", "/oshortvowelsigndeva": "\u094A", "/oslash": "\u00F8", "/oslashacute": "\u01FF", "/osmallhiragana": "\u3049", "/osmallkatakana": "\u30A9", "/osmallkatakanahalfwidth": "\uFF6B", "/ostroke": "\uA74B", "/ostrokeacute": "\u01FF", "/osuperior": "\uF6F0", "/otcyr": "\u047F", "/otcyrillic": "\u047F", "/otilde": "\u00F5", "/otildeacute": "\u1E4D", "/otildedieresis": "\u1E4F", "/otildemacron": "\u022D", "/ou": "\u0223", "/oubopomofo": "\u3121", "/ounce": "\u2125", "/outboxTray": "\u1F4E4", "/outerjoinfull": "\u27D7", "/outerjoinleft": "\u27D5", "/outerjoinright": "\u27D6", "/outputpassiveup": "\u2392", "/overlap": "\u1F5D7", "/overline": "\u203E", "/overlinecenterline": "\uFE4A", "/overlinecmb": "\u0305", "/overlinedashed": "\uFE49", "/overlinedblwavy": "\uFE4C", "/overlinewavy": "\uFE4B", "/overscore": "\u00AF", "/ovfullwidth": "\u3375", "/ovowelsignbengali": "\u09CB", "/ovowelsigndeva": "\u094B", "/ovowelsigngujarati": "\u0ACB", "/ox": "\u1F402", "/p": "\u0070", "/p.inferior": "\u209A", "/paampsfullwidth": "\u3380", "/paampssquare": "\u3380", "/paasentosquare": "\u332B", "/paatusquare": "\u332C", "/pabengali": "\u09AA", "/pacerek": "\uA989", "/package": "\u1F4E6", "/pacute": "\u1E55", "/padeva": "\u092A", "/pafullwidth": "\u33A9", "/page": "\u1F5CF", "/pageCircledText": "\u1F5DF", "/pageCurl": "\u1F4C3", "/pageFacingUp": "\u1F4C4", "/pagedown": "\u21DF", "/pager": "\u1F4DF", "/pages": "\u1F5D0", "/pageup": "\u21DE", "/pagoda": "\u1F6D4", "/pagujarati": "\u0AAA", "/pagurmukhi": "\u0A2A", "/pahiragana": "\u3071", "/paiyannoithai": "\u0E2F", "/pakatakana": "\u30D1", "/palatalizationcyrilliccmb": "\u0484", "/palatcmbcyr": "\u0484", "/pallas": "\u26B4", "/palmTree": "\u1F334", "/palmbranch": "\u2E19", "/palochkacyr": "\u04CF", "/palochkacyrillic": "\u04C0", "/pamurda": "\uA9A6", "/pandaFace": "\u1F43C", "/pangkatpada": "\uA9C7", "/pangkon": "\uA9C0", "/pangrangkep": "\uA9CF", "/pansioskorean": "\u317F", "/panyangga": "\uA980", "/paperclip": "\u1F4CE", "/paragraph": "\u00B6", "/paragraphos": "\u2E0F", "/paragraphosforked": "\u2E10", "/paragraphosforkedreversed": "\u2E11", "/paragraphseparator": "\u2029", "/parallel": "\u2225", "/parallelogramblack": "\u25B0", "/parallelogramwhite": "\u25B1", "/parenbottom": "\u23DD", "/parendblleft": "\u2E28", "/parendblright": "\u2E29", "/parenextensionleft": "\u239C", "/parenextensionright": "\u239F", "/parenflatleft": "\u27EE", "/parenflatright": "\u27EF", "/parenhookupleft": "\u239B", "/parenhookupright": "\u239E", "/parenleft": "\u0028", "/parenleft.inferior": "\u208D", "/parenleft.superior": "\u207D", "/parenleftaltonearabic": "\uFD3E", "/parenleftbt": "\uF8ED", "/parenleftex": "\uF8EC", "/parenleftinferior": "\u208D", "/parenleftmonospace": "\uFF08", "/parenleftsmall": "\uFE59", "/parenleftsuperior": "\u207D", "/parenlefttp": "\uF8EB", "/parenleftvertical": "\uFE35", "/parenlowerhookleft": "\u239D", "/parenlowerhookright": "\u23A0", "/parenright": "\u0029", "/parenright.inferior": "\u208E", "/parenright.superior": "\u207E", "/parenrightaltonearabic": "\uFD3F", "/parenrightbt": "\uF8F8", "/parenrightex": "\uF8F7", "/parenrightinferior": "\u208E", "/parenrightmonospace": "\uFF09", "/parenrightsmall": "\uFE5A", "/parenrightsuperior": "\u207E", "/parenrighttp": "\uF8F6", "/parenrightvertical": "\uFE36", "/parentop": "\u23DC", "/partalternationmark": "\u303D", "/partialdiff": "\u2202", "/partnership": "\u3250", "/partyPopper": "\u1F389", "/paseq:hb": "\u05C0", "/paseqhebrew": "\u05C0", "/pashta:hb": "\u0599", "/pashtahebrew": "\u0599", "/pasquare": "\u33A9", "/passengerShip": "\u1F6F3", "/passivedown": "\u2391", "/passportControl": "\u1F6C2", "/patah": "\u05B7", "/patah11": "\u05B7", "/patah1d": "\u05B7", "/patah2a": "\u05B7", "/patah:hb": "\u05B7", "/patahhebrew": "\u05B7", "/patahnarrowhebrew": "\u05B7", "/patahquarterhebrew": "\u05B7", "/patahwidehebrew": "\u05B7", "/pawPrints": "\u1F43E", "/pawnblack": "\u265F", "/pawnwhite": "\u2659", "/pazer:hb": "\u05A1", "/pazerhebrew": "\u05A1", "/pbopomofo": "\u3106", "/pcfullwidth": "\u3376", "/pcircle": "\u24DF", "/pdot": "\u1E57", "/pdotaccent": "\u1E57", "/pe": "\u05E4", "/pe:hb": "\u05E4", "/peace": "\u262E", "/peach": "\u1F351", "/pear": "\u1F350", "/pecyr": "\u043F", "/pecyrillic": "\u043F", "/pedagesh": "\uFB44", "/pedageshhebrew": "\uFB44", "/pedestrian": "\u1F6B6", "/peezisquare": "\u333B", "/pefinaldageshhebrew": "\uFB43", "/peh.fina": "\uFB57", "/peh.init": "\uFB58", "/peh.isol": "\uFB56", "/peh.medi": "\uFB59", "/peharabic": "\u067E", "/peharmenian": "\u057A", "/pehebrew": "\u05E4", "/peheh": "\u06A6", "/peheh.fina": "\uFB6F", "/peheh.init": "\uFB70", "/peheh.isol": "\uFB6E", "/peheh.medi": "\uFB71", "/pehfinalarabic": "\uFB57", "/pehinitialarabic": "\uFB58", "/pehiragana": "\u307A", "/pehmedialarabic": "\uFB59", "/pehookcyr": "\u04A7", "/pekatakana": "\u30DA", "/pemiddlehookcyrillic": "\u04A7", "/penOverStampedEnvelope": "\u1F586", "/pengkalconsonant": "\uA9BE", "/penguin": "\u1F427", "/penihisquare": "\u3338", "/pensiveFace": "\u1F614", "/pensusquare": "\u333A", "/pentagram": "\u26E4", "/pentasememetrical": "\u23D9", "/pepetvowel": "\uA9BC", "/per": "\u214C", "/perafehebrew": "\uFB4E", "/percent": "\u0025", "/percentarabic": "\u066A", "/percentmonospace": "\uFF05", "/percentsmall": "\uFE6A", "/percussivebidental": "\u02AD", "/percussivebilabial": "\u02AC", "/performingArts": "\u1F3AD", "/period": "\u002E", "/periodarmenian": "\u0589", "/periodcentered": "\u00B7", "/periodhalfwidth": "\uFF61", "/periodinferior": "\uF6E7", "/periodmonospace": "\uFF0E", "/periodsmall": "\uFE52", "/periodsuperior": "\uF6E8", "/periodurdu": "\u06D4", "/perispomenigreekcmb": "\u0342", "/permanentpaper": "\u267E", "/permille": "\u0609", "/perpendicular": "\u22A5", "/perseveringFace": "\u1F623", "/personBlondHair": "\u1F471", "/personBowingDeeply": "\u1F647", "/personFrowning": "\u1F64D", "/personRaisingBothHandsInCelebration": "\u1F64C", "/personWithFoldedHands": "\u1F64F", "/personWithPoutingFace": "\u1F64E", "/personalComputer": "\u1F4BB", "/personball": "\u26F9", "/perspective": "\u2306", "/pertenthousandsign": "\u2031", "/perthousand": "\u2030", "/peseta": "\u20A7", "/peso": "\u20B1", "/pesosquare": "\u3337", "/petailcyr": "\u0525", "/pewithdagesh:hb": "\uFB44", "/pewithrafe:hb": "\uFB4E", "/pffullwidth": "\u338A", "/pflourish": "\uA753", "/pfsquare": "\u338A", "/phabengali": "\u09AB", "/phadeva": "\u092B", "/phagujarati": "\u0AAB", "/phagurmukhi": "\u0A2B", "/pharyngealvoicedfricative": "\u0295", "/phfullwidth": "\u33D7", "/phi": "\u03C6", "/phi.math": "\u03D5", "/phi1": "\u03D5", "/phieuphacirclekorean": "\u327A", "/phieuphaparenkorean": "\u321A", "/phieuphcirclekorean": "\u326C", "/phieuphkorean": "\u314D", "/phieuphparenkorean": "\u320C", "/philatin": "\u0278", "/phinthuthai": "\u0E3A", "/phisymbolgreek": "\u03D5", "/phitailless": "\u2C77", "/phon:AEsmall": "\u1D01", "/phon:Aemod": "\u1D2D", "/phon:Amod": "\u1D2C", "/phon:Asmall": "\u1D00", "/phon:Bbarmod": "\u1D2F", "/phon:Bbarsmall": "\u1D03", "/phon:Bmod": "\u1D2E", "/phon:Csmall": "\u1D04", "/phon:Dmod": "\u1D30", "/phon:Dsmall": "\u1D05", "/phon:ENcyrmod": "\u1D78", "/phon:Elsmallcyr": "\u1D2B", "/phon:Emod": "\u1D31", "/phon:Ereversedmod": "\u1D32", "/phon:Esmall": "\u1D07", "/phon:Ethsmall": "\u1D06", "/phon:Ezhsmall": "\u1D23", "/phon:Gmod": "\u1D33", "/phon:Hmod": "\u1D34", "/phon:Imod": "\u1D35", "/phon:Ismallmod": "\u1DA6", "/phon:Ismallstroke": "\u1D7B", "/phon:Istrokesmallmod": "\u1DA7", "/phon:Jmod": "\u1D36", "/phon:Jsmall": "\u1D0A", "/phon:Kmod": "\u1D37", "/phon:Ksmall": "\u1D0B", "/phon:Lmod": "\u1D38", "/phon:Lsmallmod": "\u1DAB", "/phon:Lsmallstroke": "\u1D0C", "/phon:Mmod": "\u1D39", "/phon:Msmall": "\u1D0D", "/phon:Nmod": "\u1D3A", "/phon:Nreversedmod": "\u1D3B", "/phon:Nsmallmod": "\u1DB0", "/phon:Nsmallreversed": "\u1D0E", "/phon:OUsmall": "\u1D15", "/phon:Omod": "\u1D3C", "/phon:Oopensmall": "\u1D10", "/phon:Osmall": "\u1D0F", "/phon:Oumod": "\u1D3D", "/phon:Pmod": "\u1D3E", "/phon:Psmall": "\u1D18", "/phon:Rmod": "\u1D3F", "/phon:Rsmallreversed": "\u1D19", "/phon:Rsmallturned": "\u1D1A", "/phon:Tmod": "\u1D40", "/phon:Tsmall": "\u1D1B", "/phon:Umod": "\u1D41", "/phon:Usmall": "\u1D1C", "/phon:Usmallmod": "\u1DB8", "/phon:Usmallstroke": "\u1D7E", "/phon:Vsmall": "\u1D20", "/phon:Wmod": "\u1D42", "/phon:Wsmall": "\u1D21", "/phon:Zsmall": "\u1D22", "/phon:aeturned": "\u1D02", "/phon:aeturnedmod": "\u1D46", "/phon:ain": "\u1D25", "/phon:ainmod": "\u1D5C", "/phon:alphamod": "\u1D45", "/phon:alpharetroflexhook": "\u1D90", "/phon:alphaturnedmod": "\u1D9B", "/phon:amod": "\u1D43", "/phon:aretroflexhook": "\u1D8F", "/phon:aturnedmod": "\u1D44", "/phon:betamod": "\u1D5D", "/phon:bmiddletilde": "\u1D6C", "/phon:bmod": "\u1D47", "/phon:bpalatalhook": "\u1D80", "/phon:ccurlmod": "\u1D9D", "/phon:chimod": "\u1D61", "/phon:cmod": "\u1D9C", "/phon:deltamod": "\u1D5F", "/phon:dhooktail": "\u1D91", "/phon:dmiddletilde": "\u1D6D", "/phon:dmod": "\u1D48", "/phon:dotlessjstrokemod": "\u1DA1", "/phon:dpalatalhook": "\u1D81", "/phon:emod": "\u1D49", "/phon:engmod": "\u1D51", "/phon:eopenmod": "\u1D4B", "/phon:eopenretroflexhook": "\u1D93", "/phon:eopenreversedmod": "\u1D9F", "/phon:eopenreversedretroflexhook": "\u1D94", "/phon:eopenturned": "\u1D08", "/phon:eopenturnedmod": "\u1D4C", "/phon:eretroflexhook": "\u1D92", "/phon:eshmod": "\u1DB4", "/phon:eshpalatalhook": "\u1D8B", "/phon:eshretroflexhook": "\u1D98", "/phon:ethmod": "\u1D9E", "/phon:ezhmod": "\u1DBE", "/phon:ezhretroflexhook": "\u1D9A", "/phon:fmiddletilde": "\u1D6E", "/phon:fmod": "\u1DA0", "/phon:fpalatalhook": "\u1D82", "/phon:ginsular": "\u1D79", "/phon:gmod": "\u1D4D", "/phon:gpalatalhook": "\u1D83", "/phon:gr:Gammasmall": "\u1D26", "/phon:gr:Lambdasmall": "\u1D27", "/phon:gr:Pismall": "\u1D28", "/phon:gr:Psismall": "\u1D2A", "/phon:gr:RsmallHO": "\u1D29", "/phon:gr:betasubscript": "\u1D66", "/phon:gr:chisubscript": "\u1D6A", "/phon:gr:gammamod": "\u1D5E", "/phon:gr:gammasubscript": "\u1D67", "/phon:gr:phimod": "\u1D60", "/phon:gr:phisubscript": "\u1D69", "/phon:gr:rhosubscript": "\u1D68", "/phon:gscriptmod": "\u1DA2", "/phon:gturned": "\u1D77", "/phon:hturnedmod": "\u1DA3", "/phon:iotamod": "\u1DA5", "/phon:iotastroke": "\u1D7C", "/phon:iretroflexhook": "\u1D96", "/phon:istrokemod": "\u1DA4", "/phon:isubscript": "\u1D62", "/phon:iturned": "\u1D09", "/phon:iturnedmod": "\u1D4E", "/phon:jcrossedtailmod": "\u1DA8", "/phon:kmod": "\u1D4F", "/phon:kpalatalhook": "\u1D84", "/phon:lpalatalhook": "\u1D85", "/phon:lpalatalhookmod": "\u1DAA", "/phon:lretroflexhookmod": "\u1DA9", "/phon:mhookmod": "\u1DAC", "/phon:mlonglegturnedmod": "\u1DAD", "/phon:mmiddletilde": "\u1D6F", "/phon:mmod": "\u1D50", "/phon:mpalatalhook": "\u1D86", "/phon:mturnedmod": "\u1D5A", "/phon:mturnedsideways": "\u1D1F", "/phon:nlefthookmod": "\u1DAE", "/phon:nmiddletilde": "\u1D70", "/phon:npalatalhook": "\u1D87", "/phon:nretroflexhookmod": "\u1DAF", "/phon:obarmod": "\u1DB1", "/phon:obottomhalf": "\u1D17", "/phon:obottomhalfmod": "\u1D55", "/phon:oeturned": "\u1D14", "/phon:omod": "\u1D52", "/phon:oopenmod": "\u1D53", "/phon:oopenretroflexhook": "\u1D97", "/phon:oopensideways": "\u1D12", "/phon:osideways": "\u1D11", "/phon:ostrokesideways": "\u1D13", "/phon:otophalf": "\u1D16", "/phon:otophalfmod": "\u1D54", "/phon:phimod": "\u1DB2", "/phon:pmiddletilde": "\u1D71", "/phon:pmod": "\u1D56", "/phon:ppalatalhook": "\u1D88", "/phon:pstroke": "\u1D7D", "/phon:rfishmiddletilde": "\u1D73", "/phon:rmiddletilde": "\u1D72", "/phon:rpalatalhook": "\u1D89", "/phon:rsubscript": "\u1D63", "/phon:schwamod": "\u1D4A", "/phon:schwaretroflexhook": "\u1D95", "/phon:shookmod": "\u1DB3", "/phon:smiddletilde": "\u1D74", "/phon:spalatalhook": "\u1D8A", "/phon:spirantvoicedlaryngeal": "\u1D24", "/phon:thetamod": "\u1DBF", "/phon:thstrike": "\u1D7A", "/phon:tmiddletilde": "\u1D75", "/phon:tmod": "\u1D57", "/phon:tpalatalhookmod": "\u1DB5", "/phon:ubarmod": "\u1DB6", "/phon:ue": "\u1D6B", "/phon:umod": "\u1D58", "/phon:upsilonmod": "\u1DB7", "/phon:upsilonstroke": "\u1D7F", "/phon:uretroflexhook": "\u1D99", "/phon:usideways": "\u1D1D", "/phon:usidewaysdieresised": "\u1D1E", "/phon:usidewaysmod": "\u1D59", "/phon:usubscript": "\u1D64", "/phon:vhookmod": "\u1DB9", "/phon:vmod": "\u1D5B", "/phon:vpalatalhook": "\u1D8C", "/phon:vsubscript": "\u1D65", "/phon:vturnedmod": "\u1DBA", "/phon:xpalatalhook": "\u1D8D", "/phon:zcurlmod": "\u1DBD", "/phon:zmiddletilde": "\u1D76", "/phon:zmod": "\u1DBB", "/phon:zpalatalhook": "\u1D8E", "/phon:zretroflexhookmod": "\u1DBC", "/phook": "\u01A5", "/phophanthai": "\u0E1E", "/phophungthai": "\u0E1C", "/phosamphaothai": "\u0E20", "/pi": "\u03C0", "/pi.math": "\u03D6", "/piasutorusquare": "\u332E", "/pick": "\u26CF", "/pidblstruck": "\u213C", "/pieupacirclekorean": "\u3273", "/pieupaparenkorean": "\u3213", "/pieupcieuckorean": "\u3176", "/pieupcirclekorean": "\u3265", "/pieupkiyeokkorean": "\u3172", "/pieupkorean": "\u3142", "/pieupparenkorean": "\u3205", "/pieupsioskiyeokkorean": "\u3174", "/pieupsioskorean": "\u3144", "/pieupsiostikeutkorean": "\u3175", "/pieupthieuthkorean": "\u3177", "/pieuptikeutkorean": "\u3173", "/pig": "\u1F416", "/pigFace": "\u1F437", "/pigNose": "\u1F43D", "/pihiragana": "\u3074", "/pikatakana": "\u30D4", "/pikosquare": "\u3330", "/pikurusquare": "\u332F", "/pilcrowsignreversed": "\u204B", "/pileOfPoo": "\u1F4A9", "/pill": "\u1F48A", "/pineDecoration": "\u1F38D", "/pineapple": "\u1F34D", "/pisces": "\u2653", "/piselehpada": "\uA9CC", "/pistol": "\u1F52B", "/pisymbolgreek": "\u03D6", "/pitchfork": "\u22D4", "/piwrarmenian": "\u0583", "/placeOfWorship": "\u1F6D0", "/placeofinterestsign": "\u2318", "/planck": "\u210E", "/plancktwopi": "\u210F", "/plus": "\u002B", "/plus.inferior": "\u208A", "/plus.superior": "\u207A", "/plusbelowcmb": "\u031F", "/pluscircle": "\u2295", "/plusminus": "\u00B1", "/plusmod": "\u02D6", "/plusmonospace": "\uFF0B", "/plussignalt:hb": "\uFB29", "/plussignmod": "\u02D6", "/plussmall": "\uFE62", "/plussuperior": "\u207A", "/pluto": "\u2647", "/pmfullwidth": "\u33D8", "/pmonospace": "\uFF50", "/pmsquare": "\u33D8", "/pocketCalculator": "\u1F5A9", "/poeticverse": "\u060E", "/pohiragana": "\u307D", "/pointerleftblack": "\u25C4", "/pointerleftwhite": "\u25C5", "/pointerrightblack": "\u25BA", "/pointerrightwhite": "\u25BB", "/pointingindexdownwhite": "\u261F", "/pointingindexleftblack": "\u261A", "/pointingindexleftwhite": "\u261C", "/pointingindexrightblack": "\u261B", "/pointingindexrightwhite": "\u261E", "/pointingindexupwhite": "\u261D", "/pointingtriangledownheavywhite": "\u26DB", "/pointosquare": "\u333D", "/pointring": "\u2E30", "/pokatakana": "\u30DD", "/pokrytiecmbcyr": "\u0487", "/policeCar": "\u1F693", "/policeCarsRevolvingLight": "\u1F6A8", "/policeOfficer": "\u1F46E", "/pondosquare": "\u3340", "/poodle": "\u1F429", "/popcorn": "\u1F37F", "/popdirectionalformatting": "\u202C", "/popdirectionalisolate": "\u2069", "/poplathai": "\u0E1B", "/portableStereo": "\u1F4FE", "/positionindicator": "\u2316", "/postalHorn": "\u1F4EF", "/postalmark": "\u3012", "/postalmarkface": "\u3020", "/postbox": "\u1F4EE", "/potOfFood": "\u1F372", "/potableWater": "\u1F6B0", "/pouch": "\u1F45D", "/poultryLeg": "\u1F357", "/poutingCatFace": "\u1F63E", "/poutingFace": "\u1F621", "/power": "\u23FB", "/poweron": "\u23FD", "/poweronoff": "\u23FC", "/powersleep": "\u23FE", "/pparen": "\u24AB", "/pparenthesized": "\u24AB", "/ppmfullwidth": "\u33D9", "/prayerBeads": "\u1F4FF", "/precedes": "\u227A", "/precedesbutnotequivalent": "\u22E8", "/precedesorequal": "\u227C", "/precedesorequivalent": "\u227E", "/precedesunderrelation": "\u22B0", "/prescription": "\u211E", "/preversedepigraphic": "\uA7FC", "/previouspage": "\u2397", "/prfullwidth": "\u33DA", "/primedblmod": "\u02BA", "/primemod": "\u02B9", "/primereversed": "\u2035", "/princess": "\u1F478", "/printer": "\u1F5A8", "/printerIcon": "\u1F5B6", "/printideographiccircled": "\u329E", "/printscreen": "\u2399", "/product": "\u220F", "/prohibitedSign": "\u1F6C7", "/projective": "\u2305", "/prolongedkana": "\u30FC", "/propellor": "\u2318", "/propersubset": "\u2282", "/propersuperset": "\u2283", "/propertyline": "\u214A", "/proportion": "\u2237", "/proportional": "\u221D", "/psfullwidth": "\u33B0", "/psi": "\u03C8", "/psicyr": "\u0471", "/psicyrillic": "\u0471", "/psilicmbcyr": "\u0486", "/psilipneumatacyrilliccmb": "\u0486", "/pssquare": "\u33B0", "/pstrokedescender": "\uA751", "/ptail": "\uA755", "/publicAddressLoudspeaker": "\u1F4E2", "/puhiragana": "\u3077", "/pukatakana": "\u30D7", "/punctuationspace": "\u2008", "/purpleHeart": "\u1F49C", "/purse": "\u1F45B", "/pushpin": "\u1F4CC", "/putLitterInItsPlace": "\u1F6AE", "/pvfullwidth": "\u33B4", "/pvsquare": "\u33B4", "/pwfullwidth": "\u33BA", "/pwsquare": "\u33BA", "/q": "\u0071", "/qacyr": "\u051B", "/qadeva": "\u0958", "/qadma:hb": "\u05A8", "/qadmahebrew": "\u05A8", "/qaf": "\u0642", "/qaf.fina": "\uFED6", "/qaf.init": "\uFED7", "/qaf.init_alefmaksura.fina": "\uFC35", "/qaf.init_hah.fina": "\uFC33", "/qaf.init_hah.medi": "\uFCC2", "/qaf.init_meem.fina": "\uFC34", "/qaf.init_meem.medi": "\uFCC3", "/qaf.init_meem.medi_hah.medi": "\uFDB4", "/qaf.init_yeh.fina": "\uFC36", "/qaf.isol": "\uFED5", "/qaf.medi": "\uFED8", "/qaf.medi_alefmaksura.fina": "\uFC7E", "/qaf.medi_meem.medi_hah.fina": "\uFD7E", "/qaf.medi_meem.medi_meem.fina": "\uFD7F", "/qaf.medi_meem.medi_yeh.fina": "\uFDB2", "/qaf.medi_yeh.fina": "\uFC7F", "/qaf_lam_alefmaksuraabove": "\u06D7", "/qafarabic": "\u0642", "/qafdotabove": "\u06A7", "/qaffinalarabic": "\uFED6", "/qafinitialarabic": "\uFED7", "/qafmedialarabic": "\uFED8", "/qafthreedotsabove": "\u06A8", "/qamats": "\u05B8", "/qamats10": "\u05B8", "/qamats1a": "\u05B8", "/qamats1c": "\u05B8", "/qamats27": "\u05B8", "/qamats29": "\u05B8", "/qamats33": "\u05B8", "/qamats:hb": "\u05B8", "/qamatsQatan:hb": "\u05C7", "/qamatsde": "\u05B8", "/qamatshebrew": "\u05B8", "/qamatsnarrowhebrew": "\u05B8", "/qamatsqatanhebrew": "\u05B8", "/qamatsqatannarrowhebrew": "\u05B8", "/qamatsqatanquarterhebrew": "\u05B8", "/qamatsqatanwidehebrew": "\u05B8", "/qamatsquarterhebrew": "\u05B8", "/qamatswidehebrew": "\u05B8", "/qarneFarah:hb": "\u059F", "/qarneyparahebrew": "\u059F", "/qbopomofo": "\u3111", "/qcircle": "\u24E0", "/qdiagonalstroke": "\uA759", "/qhook": "\u02A0", "/qhooktail": "\u024B", "/qmonospace": "\uFF51", "/qof": "\u05E7", "/qof:hb": "\u05E7", "/qofdagesh": "\uFB47", "/qofdageshhebrew": "\uFB47", "/qofhatafpatah": "\u05E7", "/qofhatafpatahhebrew": "\u05E7", "/qofhatafsegol": "\u05E7", "/qofhatafsegolhebrew": "\u05E7", "/qofhebrew": "\u05E7", "/qofhiriq": "\u05E7", "/qofhiriqhebrew": "\u05E7", "/qofholam": "\u05E7", "/qofholamhebrew": "\u05E7", "/qofpatah": "\u05E7", "/qofpatahhebrew": "\u05E7", "/qofqamats": "\u05E7", "/qofqamatshebrew": "\u05E7", "/qofqubuts": "\u05E7", "/qofqubutshebrew": "\u05E7", "/qofsegol": "\u05E7", "/qofsegolhebrew": "\u05E7", "/qofsheva": "\u05E7", "/qofshevahebrew": "\u05E7", "/qoftsere": "\u05E7", "/qoftserehebrew": "\u05E7", "/qofwithdagesh:hb": "\uFB47", "/qparen": "\u24AC", "/qparenthesized": "\u24AC", "/qpdigraph": "\u0239", "/qstrokedescender": "\uA757", "/quadarrowdownfunc": "\u2357", "/quadarrowleftfunc": "\u2347", "/quadarrowrightfunc": "\u2348", "/quadarrowupfunc": "\u2350", "/quadbackslashfunc": "\u2342", "/quadcaretdownfunc": "\u234C", "/quadcaretupfunc": "\u2353", "/quadcirclefunc": "\u233C", "/quadcolonfunc": "\u2360", "/quaddelfunc": "\u2354", "/quaddeltafunc": "\u234D", "/quaddiamondfunc": "\u233A", "/quaddividefunc": "\u2339", "/quadequalfunc": "\u2338", "/quadfunc": "\u2395", "/quadgreaterfunc": "\u2344", "/quadjotfunc": "\u233B", "/quadlessfunc": "\u2343", "/quadnotequalfunc": "\u236F", "/quadquestionfunc": "\u2370", "/quadrantLowerLeft": "\u2596", "/quadrantLowerRight": "\u2597", "/quadrantUpperLeft": "\u2598", "/quadrantUpperLeftAndLowerLeftAndLowerRight": "\u2599", "/quadrantUpperLeftAndLowerRight": "\u259A", "/quadrantUpperLeftAndUpperRightAndLowerLeft": "\u259B", "/quadrantUpperLeftAndUpperRightAndLowerRight": "\u259C", "/quadrantUpperRight": "\u259D", "/quadrantUpperRightAndLowerLeft": "\u259E", "/quadrantUpperRightAndLowerLeftAndLowerRight": "\u259F", "/quadrupleminute": "\u2057", "/quadslashfunc": "\u2341", "/quarternote": "\u2669", "/qubuts": "\u05BB", "/qubuts18": "\u05BB", "/qubuts25": "\u05BB", "/qubuts31": "\u05BB", "/qubuts:hb": "\u05BB", "/qubutshebrew": "\u05BB", "/qubutsnarrowhebrew": "\u05BB", "/qubutsquarterhebrew": "\u05BB", "/qubutswidehebrew": "\u05BB", "/queenblack": "\u265B", "/queenwhite": "\u2655", "/question": "\u003F", "/questionarabic": "\u061F", "/questionarmenian": "\u055E", "/questiondbl": "\u2047", "/questiondown": "\u00BF", "/questiondownsmall": "\uF7BF", "/questionedequal": "\u225F", "/questionexclamationmark": "\u2048", "/questiongreek": "\u037E", "/questionideographiccircled": "\u3244", "/questionmonospace": "\uFF1F", "/questionreversed": "\u2E2E", "/questionsmall": "\uF73F", "/quincunx": "\u26BB", "/quotedbl": "\u0022", "/quotedblbase": "\u201E", "/quotedblleft": "\u201C", "/quotedbllowreversed": "\u2E42", "/quotedblmonospace": "\uFF02", "/quotedblprime": "\u301E", "/quotedblprimereversed": "\u301D", "/quotedblreversed": "\u201F", "/quotedblright": "\u201D", "/quoteleft": "\u2018", "/quoteleftreversed": "\u201B", "/quotequadfunc": "\u235E", "/quotereversed": "\u201B", "/quoteright": "\u2019", "/quoterightn": "\u0149", "/quotesinglbase": "\u201A", "/quotesingle": "\u0027", "/quotesinglemonospace": "\uFF07", "/quoteunderlinefunc": "\u2358", "/r": "\u0072", "/raagung": "\uA9AC", "/raarmenian": "\u057C", "/rabbit": "\u1F407", "/rabbitFace": "\u1F430", "/rabengali": "\u09B0", "/racingCar": "\u1F3CE", "/racingMotorcycle": "\u1F3CD", "/racirclekatakana": "\u32F6", "/racute": "\u0155", "/radeva": "\u0930", "/radfullwidth": "\u33AD", "/radical": "\u221A", "/radicalbottom": "\u23B7", "/radicalex": "\uF8E5", "/radio": "\u1F4FB", "/radioButton": "\u1F518", "/radioactive": "\u2622", "/radovers2fullwidth": "\u33AF", "/radoversfullwidth": "\u33AE", "/radoverssquare": "\u33AE", "/radoverssquaredsquare": "\u33AF", "/radsquare": "\u33AD", "/rafe": "\u05BF", "/rafe:hb": "\u05BF", "/rafehebrew": "\u05BF", "/ragujarati": "\u0AB0", "/ragurmukhi": "\u0A30", "/rahiragana": "\u3089", "/railwayCar": "\u1F683", "/railwayTrack": "\u1F6E4", "/rain": "\u26C6", "/rainbow": "\u1F308", "/raisedHandFingersSplayed": "\u1F590", "/raisedHandPartBetweenMiddleAndRingFingers": "\u1F596", "/raisedmcsign": "\u1F16A", "/raisedmdsign": "\u1F16B", "/rakatakana": "\u30E9", "/rakatakanahalfwidth": "\uFF97", "/ralowerdiagonalbengali": "\u09F1", "/ram": "\u1F40F", "/ramiddlediagonalbengali": "\u09F0", "/ramshorn": "\u0264", "/rat": "\u1F400", "/ratio": "\u2236", "/ray": "\u0608", "/rbopomofo": "\u3116", "/rcaron": "\u0159", "/rcedilla": "\u0157", "/rcircle": "\u24E1", "/rcommaaccent": "\u0157", "/rdblgrave": "\u0211", "/rdot": "\u1E59", "/rdotaccent": "\u1E59", "/rdotbelow": "\u1E5B", "/rdotbelowmacron": "\u1E5D", "/reachideographicparen": "\u3243", "/recirclekatakana": "\u32F9", "/recreationalVehicle": "\u1F699", "/rectangleblack": "\u25AC", "/rectangleverticalblack": "\u25AE", "/rectangleverticalwhite": "\u25AF", "/rectanglewhite": "\u25AD", "/recycledpaper": "\u267C", "/recyclefiveplastics": "\u2677", "/recyclefourplastics": "\u2676", "/recyclegeneric": "\u267A", "/recycleoneplastics": "\u2673", "/recyclepartiallypaper": "\u267D", "/recyclesevenplastics": "\u2679", "/recyclesixplastics": "\u2678", "/recyclethreeplastics": "\u2675", "/recycletwoplastics": "\u2674", "/recycleuniversal": "\u2672", "/recycleuniversalblack": "\u267B", "/redApple": "\u1F34E", "/redTriangleDOwn": "\u1F53B", "/redTriangleUp": "\u1F53A", "/referencemark": "\u203B", "/reflexsubset": "\u2286", "/reflexsuperset": "\u2287", "/regionalindicatorsymbollettera": "\u1F1E6", "/regionalindicatorsymbolletterb": "\u1F1E7", "/regionalindicatorsymbolletterc": "\u1F1E8", "/regionalindicatorsymbolletterd": "\u1F1E9", "/regionalindicatorsymbollettere": "\u1F1EA", "/regionalindicatorsymbolletterf": "\u1F1EB", "/regionalindicatorsymbolletterg": "\u1F1EC", "/regionalindicatorsymbolletterh": "\u1F1ED", "/regionalindicatorsymbolletteri": "\u1F1EE", "/regionalindicatorsymbolletterj": "\u1F1EF", "/regionalindicatorsymbolletterk": "\u1F1F0", "/regionalindicatorsymbolletterl": "\u1F1F1", "/regionalindicatorsymbolletterm": "\u1F1F2", "/regionalindicatorsymbollettern": "\u1F1F3", "/regionalindicatorsymbollettero": "\u1F1F4", "/regionalindicatorsymbolletterp": "\u1F1F5", "/regionalindicatorsymbolletterq": "\u1F1F6", "/regionalindicatorsymbolletterr": "\u1F1F7", "/regionalindicatorsymbolletters": "\u1F1F8", "/regionalindicatorsymbollettert": "\u1F1F9", "/regionalindicatorsymbolletteru": "\u1F1FA", "/regionalindicatorsymbolletterv": "\u1F1FB", "/regionalindicatorsymbolletterw": "\u1F1FC", "/regionalindicatorsymbolletterx": "\u1F1FD", "/regionalindicatorsymbollettery": "\u1F1FE", "/regionalindicatorsymbolletterz": "\u1F1FF", "/registered": "\u00AE", "/registersans": "\uF8E8", "/registerserif": "\uF6DA", "/reh.fina": "\uFEAE", "/reh.init_superscriptalef.fina": "\uFC5C", "/reh.isol": "\uFEAD", "/rehHamzaAbove": "\u076C", "/rehSmallTahTwoDots": "\u0771", "/rehStroke": "\u075B", "/rehTwoDotsVerticallyAbove": "\u076B", "/rehVabove": "\u0692", "/rehVbelow": "\u0695", "/reharabic": "\u0631", "/reharmenian": "\u0580", "/rehdotbelow": "\u0694", "/rehdotbelowdotabove": "\u0696", "/rehfinalarabic": "\uFEAE", "/rehfourdotsabove": "\u0699", "/rehinvertedV": "\u06EF", "/rehiragana": "\u308C", "/rehring": "\u0693", "/rehtwodotsabove": "\u0697", "/rehyehaleflamarabic": "\u0631", "/rekatakana": "\u30EC", "/rekatakanahalfwidth": "\uFF9A", "/relievedFace": "\u1F60C", "/religionideographiccircled": "\u32AA", "/reminderRibbon": "\u1F397", "/remusquare": "\u3355", "/rentogensquare": "\u3356", "/replacementchar": "\uFFFD", "/replacementcharobj": "\uFFFC", "/representideographicparen": "\u3239", "/rerengganleft": "\uA9C1", "/rerengganright": "\uA9C2", "/resh": "\u05E8", "/resh:hb": "\u05E8", "/reshdageshhebrew": "\uFB48", "/reshhatafpatah": "\u05E8", "/reshhatafpatahhebrew": "\u05E8", "/reshhatafsegol": "\u05E8", "/reshhatafsegolhebrew": "\u05E8", "/reshhebrew": "\u05E8", "/reshhiriq": "\u05E8", "/reshhiriqhebrew": "\u05E8", "/reshholam": "\u05E8", "/reshholamhebrew": "\u05E8", "/reshpatah": "\u05E8", "/reshpatahhebrew": "\u05E8", "/reshqamats": "\u05E8", "/reshqamatshebrew": "\u05E8", "/reshqubuts": "\u05E8", "/reshqubutshebrew": "\u05E8", "/reshsegol": "\u05E8", "/reshsegolhebrew": "\u05E8", "/reshsheva": "\u05E8", "/reshshevahebrew": "\u05E8", "/reshtsere": "\u05E8", "/reshtserehebrew": "\u05E8", "/reshwide:hb": "\uFB27", "/reshwithdagesh:hb": "\uFB48", "/resourceideographiccircled": "\u32AE", "/resourceideographicparen": "\u323E", "/response": "\u211F", "/restideographiccircled": "\u32A1", "/restideographicparen": "\u3241", "/restrictedentryoneleft": "\u26E0", "/restrictedentrytwoleft": "\u26E1", "/restroom": "\u1F6BB", "/return": "\u23CE", "/reversedHandMiddleFingerExtended": "\u1F595", "/reversedRaisedHandFingersSplayed": "\u1F591", "/reversedThumbsDownSign": "\u1F593", "/reversedThumbsUpSign": "\u1F592", "/reversedVictoryHand": "\u1F594", "/reversedonehundred.roman": "\u2183", "/reversedtilde": "\u223D", "/reversedzecyr": "\u0511", "/revia:hb": "\u0597", "/reviahebrew": "\u0597", "/reviamugrashhebrew": "\u0597", "/revlogicalnot": "\u2310", "/revolvingHearts": "\u1F49E", "/rfishhook": "\u027E", "/rfishhookreversed": "\u027F", "/rgravedbl": "\u0211", "/rhabengali": "\u09DD", "/rhacyr": "\u0517", "/rhadeva": "\u095D", "/rho": "\u03C1", "/rhoasper": "\u1FE5", "/rhofunc": "\u2374", "/rholenis": "\u1FE4", "/rhook": "\u027D", "/rhookturned": "\u027B", "/rhookturnedsuperior": "\u02B5", "/rhookturnedsupmod": "\u02B5", "/rhostrokesymbol": "\u03FC", "/rhosymbol": "\u03F1", "/rhosymbolgreek": "\u03F1", "/rhotichookmod": "\u02DE", "/rial": "\uFDFC", "/ribbon": "\u1F380", "/riceBall": "\u1F359", "/riceCracker": "\u1F358", "/ricirclekatakana": "\u32F7", "/rieulacirclekorean": "\u3271", "/rieulaparenkorean": "\u3211", "/rieulcirclekorean": "\u3263", "/rieulhieuhkorean": "\u3140", "/rieulkiyeokkorean": "\u313A", "/rieulkiyeoksioskorean": "\u3169", "/rieulkorean": "\u3139", "/rieulmieumkorean": "\u313B", "/rieulpansioskorean": "\u316C", "/rieulparenkorean": "\u3203", "/rieulphieuphkorean": "\u313F", "/rieulpieupkorean": "\u313C", "/rieulpieupsioskorean": "\u316B", "/rieulsioskorean": "\u313D", "/rieulthieuthkorean": "\u313E", "/rieultikeutkorean": "\u316A", "/rieulyeorinhieuhkorean": "\u316D", "/right-pointingMagnifyingGlass": "\u1F50E", "/rightAngerBubble": "\u1F5EF", "/rightHalfBlock": "\u2590", "/rightHandTelephoneReceiver": "\u1F57D", "/rightOneEighthBlock": "\u2595", "/rightSpeaker": "\u1F568", "/rightSpeakerOneSoundWave": "\u1F569", "/rightSpeakerThreeSoundWaves": "\u1F56A", "/rightSpeechBubble": "\u1F5E9", "/rightThoughtBubble": "\u1F5ED", "/rightangle": "\u221F", "/rightarrowoverleftarrow": "\u21C4", "/rightdnheavyleftuplight": "\u2546", "/rightharpoonoverleftharpoon": "\u21CC", "/rightheavyleftdnlight": "\u252E", "/rightheavyleftuplight": "\u2536", "/rightheavyleftvertlight": "\u253E", "/rightideographiccircled": "\u32A8", "/rightlightleftdnheavy": "\u2531", "/rightlightleftupheavy": "\u2539", "/rightlightleftvertheavy": "\u2549", "/righttackbelowcmb": "\u0319", "/righttoleftembed": "\u202B", "/righttoleftisolate": "\u2067", "/righttoleftmark": "\u200F", "/righttoleftoverride": "\u202E", "/righttriangle": "\u22BF", "/rightupheavyleftdnlight": "\u2544", "/rihiragana": "\u308A", "/rikatakana": "\u30EA", "/rikatakanahalfwidth": "\uFF98", "/ring": "\u02DA", "/ringbelowcmb": "\u0325", "/ringcmb": "\u030A", "/ringequal": "\u2257", "/ringhalfleft": "\u02BF", "/ringhalfleftarmenian": "\u0559", "/ringhalfleftbelowcmb": "\u031C", "/ringhalfleftcentered": "\u02D3", "/ringhalfleftcentredmod": "\u02D3", "/ringhalfleftmod": "\u02BF", "/ringhalfright": "\u02BE", "/ringhalfrightbelowcmb": "\u0339", "/ringhalfrightcentered": "\u02D2", "/ringhalfrightcentredmod": "\u02D2", "/ringhalfrightmod": "\u02BE", "/ringinequal": "\u2256", "/ringingBell": "\u1F56D", "/ringlowmod": "\u02F3", "/ringoperator": "\u2218", "/rinsular": "\uA783", "/rinvertedbreve": "\u0213", "/rirasquare": "\u3352", "/risingdiagonal": "\u27CB", "/rittorusquare": "\u3351", "/rlinebelow": "\u1E5F", "/rlongleg": "\u027C", "/rlonglegturned": "\u027A", "/rmacrondot": "\u1E5D", "/rmonospace": "\uFF52", "/rnoon": "\u06BB", "/rnoon.fina": "\uFBA1", "/rnoon.init": "\uFBA2", "/rnoon.isol": "\uFBA0", "/rnoon.medi": "\uFBA3", "/roastedSweetPotato": "\u1F360", "/robliquestroke": "\uA7A7", "/rocirclekatakana": "\u32FA", "/rocket": "\u1F680", "/rohiragana": "\u308D", "/rokatakana": "\u30ED", "/rokatakanahalfwidth": "\uFF9B", "/rolled-upNewspaper": "\u1F5DE", "/rollerCoaster": "\u1F3A2", "/rookblack": "\u265C", "/rookwhite": "\u2656", "/rooster": "\u1F413", "/roruathai": "\u0E23", "/rose": "\u1F339", "/rosette": "\u1F3F5", "/roundPushpin": "\u1F4CD", "/roundedzeroabove": "\u06DF", "/rowboat": "\u1F6A3", "/rparen": "\u24AD", "/rparenthesized": "\u24AD", "/rrabengali": "\u09DC", "/rradeva": "\u0931", "/rragurmukhi": "\u0A5C", "/rreh": "\u0691", "/rreh.fina": "\uFB8D", "/rreh.isol": "\uFB8C", "/rreharabic": "\u0691", "/rrehfinalarabic": "\uFB8D", "/rrotunda": "\uA75B", "/rrvocalicbengali": "\u09E0", "/rrvocalicdeva": "\u0960", "/rrvocalicgujarati": "\u0AE0", "/rrvocalicvowelsignbengali": "\u09C4", "/rrvocalicvowelsigndeva": "\u0944", "/rrvocalicvowelsigngujarati": "\u0AC4", "/rstroke": "\u024D", "/rsuperior": "\uF6F1", "/rsupmod": "\u02B3", "/rtailturned": "\u2C79", "/rtblock": "\u2590", "/rturned": "\u0279", "/rturnedsuperior": "\u02B4", "/rturnedsupmod": "\u02B4", "/ruble": "\u20BD", "/rucirclekatakana": "\u32F8", "/rugbyFootball": "\u1F3C9", "/ruhiragana": "\u308B", "/rukatakana": "\u30EB", "/rukatakanahalfwidth": "\uFF99", "/rum": "\uA775", "/rumrotunda": "\uA75D", "/runner": "\u1F3C3", "/runningShirtSash": "\u1F3BD", "/rupeemarkbengali": "\u09F2", "/rupeesignbengali": "\u09F3", "/rupiah": "\uF6DD", "/rupiisquare": "\u3353", "/ruthai": "\u0E24", "/ruuburusquare": "\u3354", "/rvocalicbengali": "\u098B", "/rvocalicdeva": "\u090B", "/rvocalicgujarati": "\u0A8B", "/rvocalicvowelsignbengali": "\u09C3", "/rvocalicvowelsigndeva": "\u0943", "/rvocalicvowelsigngujarati": "\u0AC3", "/s": "\u0073", "/s.inferior": "\u209B", "/s_t": "\uFB06", "/sabengali": "\u09B8", "/sacirclekatakana": "\u32DA", "/sacute": "\u015B", "/sacutedotaccent": "\u1E65", "/sad": "\u0635", "/sad.fina": "\uFEBA", "/sad.init": "\uFEBB", "/sad.init_alefmaksura.fina": "\uFD05", "/sad.init_hah.fina": "\uFC20", "/sad.init_hah.medi": "\uFCB1", "/sad.init_hah.medi_hah.medi": "\uFD65", "/sad.init_khah.medi": "\uFCB2", "/sad.init_meem.fina": "\uFC21", "/sad.init_meem.medi": "\uFCB3", "/sad.init_meem.medi_meem.medi": "\uFDC5", "/sad.init_reh.fina": "\uFD0F", "/sad.init_yeh.fina": "\uFD06", "/sad.isol": "\uFEB9", "/sad.medi": "\uFEBC", "/sad.medi_alefmaksura.fina": "\uFD21", "/sad.medi_hah.medi_hah.fina": "\uFD64", "/sad.medi_hah.medi_yeh.fina": "\uFDA9", "/sad.medi_meem.medi_meem.fina": "\uFD66", "/sad.medi_reh.fina": "\uFD2B", "/sad.medi_yeh.fina": "\uFD22", "/sad_lam_alefmaksuraabove": "\u06D6", "/sadarabic": "\u0635", "/sadeva": "\u0938", "/sadfinalarabic": "\uFEBA", "/sadinitialarabic": "\uFEBB", "/sadmedialarabic": "\uFEBC", "/sadthreedotsabove": "\u069E", "/sadtwodotsbelow": "\u069D", "/sagittarius": "\u2650", "/sagujarati": "\u0AB8", "/sagurmukhi": "\u0A38", "/sahiragana": "\u3055", "/saikurusquare": "\u331F", "/sailboat": "\u26F5", "/sakatakana": "\u30B5", "/sakatakanahalfwidth": "\uFF7B", "/sakeBottleAndCup": "\u1F376", "/sallallahoualayhewasallamarabic": "\uFDFA", "/saltillo": "\uA78C", "/saltire": "\u2613", "/samahaprana": "\uA9B0", "/samekh": "\u05E1", "/samekh:hb": "\u05E1", "/samekhdagesh": "\uFB41", "/samekhdageshhebrew": "\uFB41", "/samekhhebrew": "\u05E1", "/samekhwithdagesh:hb": "\uFB41", "/sampi": "\u03E1", "/sampiarchaic": "\u0373", "/samurda": "\uA9AF", "/samvat": "\u0604", "/san": "\u03FB", "/santiimusquare": "\u3320", "/saraaathai": "\u0E32", "/saraaethai": "\u0E41", "/saraaimaimalaithai": "\u0E44", "/saraaimaimuanthai": "\u0E43", "/saraamthai": "\u0E33", "/saraathai": "\u0E30", "/saraethai": "\u0E40", "/saraiileftthai": "\uF886", "/saraiithai": "\u0E35", "/saraileftthai": "\uF885", "/saraithai": "\u0E34", "/saraothai": "\u0E42", "/saraueeleftthai": "\uF888", "/saraueethai": "\u0E37", "/saraueleftthai": "\uF887", "/sarauethai": "\u0E36", "/sarauthai": "\u0E38", "/sarauuthai": "\u0E39", "/satellite": "\u1F6F0", "/satelliteAntenna": "\u1F4E1", "/saturn": "\u2644", "/saxophone": "\u1F3B7", "/sbopomofo": "\u3119", "/scales": "\u2696", "/scanninehorizontal": "\u23BD", "/scanonehorizontal": "\u23BA", "/scansevenhorizontal": "\u23BC", "/scanthreehorizontal": "\u23BB", "/scaron": "\u0161", "/scarondot": "\u1E67", "/scarondotaccent": "\u1E67", "/scedilla": "\u015F", "/school": "\u1F3EB", "/schoolSatchel": "\u1F392", "/schoolideographiccircled": "\u3246", "/schwa": "\u0259", "/schwa.inferior": "\u2094", "/schwacyr": "\u04D9", "/schwacyrillic": "\u04D9", "/schwadieresiscyr": "\u04DB", "/schwadieresiscyrillic": "\u04DB", "/schwahook": "\u025A", "/scircle": "\u24E2", "/scircumflex": "\u015D", "/scommaaccent": "\u0219", "/scooter": "\u1F6F4", "/scorpius": "\u264F", "/screen": "\u1F5B5", "/scroll": "\u1F4DC", "/scruple": "\u2108", "/sdot": "\u1E61", "/sdotaccent": "\u1E61", "/sdotbelow": "\u1E63", "/sdotbelowdotabove": "\u1E69", "/sdotbelowdotaccent": "\u1E69", "/seagullbelowcmb": "\u033C", "/seat": "\u1F4BA", "/secirclekatakana": "\u32DD", "/second": "\u2033", "/secondreversed": "\u2036", "/secondscreensquare": "\u1F19C", "/secondtonechinese": "\u02CA", "/secretideographiccircled": "\u3299", "/section": "\u00A7", "/sectionsignhalftop": "\u2E39", "/sector": "\u2314", "/seeNoEvilMonkey": "\u1F648", "/seedling": "\u1F331", "/seen": "\u0633", "/seen.fina": "\uFEB2", "/seen.init": "\uFEB3", "/seen.init_alefmaksura.fina": "\uFCFB", "/seen.init_hah.fina": "\uFC1D", "/seen.init_hah.medi": "\uFCAE", "/seen.init_hah.medi_jeem.medi": "\uFD5C", "/seen.init_heh.medi": "\uFD31", "/seen.init_jeem.fina": "\uFC1C", "/seen.init_jeem.medi": "\uFCAD", "/seen.init_jeem.medi_hah.medi": "\uFD5D", "/seen.init_khah.fina": "\uFC1E", "/seen.init_khah.medi": "\uFCAF", "/seen.init_meem.fina": "\uFC1F", "/seen.init_meem.medi": "\uFCB0", "/seen.init_meem.medi_hah.medi": "\uFD60", "/seen.init_meem.medi_jeem.medi": "\uFD61", "/seen.init_meem.medi_meem.medi": "\uFD63", "/seen.init_reh.fina": "\uFD0E", "/seen.init_yeh.fina": "\uFCFC", "/seen.isol": "\uFEB1", "/seen.medi": "\uFEB4", "/seen.medi_alefmaksura.fina": "\uFD17", "/seen.medi_hah.medi": "\uFD35", "/seen.medi_heh.medi": "\uFCE8", "/seen.medi_jeem.medi": "\uFD34", "/seen.medi_jeem.medi_alefmaksura.fina": "\uFD5E", "/seen.medi_khah.medi": "\uFD36", "/seen.medi_khah.medi_alefmaksura.fina": "\uFDA8", "/seen.medi_khah.medi_yeh.fina": "\uFDC6", "/seen.medi_meem.medi": "\uFCE7", "/seen.medi_meem.medi_hah.fina": "\uFD5F", "/seen.medi_meem.medi_meem.fina": "\uFD62", "/seen.medi_reh.fina": "\uFD2A", "/seen.medi_yeh.fina": "\uFD18", "/seenDigitFourAbove": "\u077D", "/seenFourDotsAbove": "\u075C", "/seenInvertedV": "\u077E", "/seenSmallTahTwoDots": "\u0770", "/seenTwoDotsVerticallyAbove": "\u076D", "/seenabove": "\u06DC", "/seenarabic": "\u0633", "/seendotbelowdotabove": "\u069A", "/seenfinalarabic": "\uFEB2", "/seeninitialarabic": "\uFEB3", "/seenlow": "\u06E3", "/seenmedialarabic": "\uFEB4", "/seenthreedotsbelow": "\u069B", "/seenthreedotsbelowthreedotsabove": "\u069C", "/segment": "\u2313", "/segol": "\u05B6", "/segol13": "\u05B6", "/segol1f": "\u05B6", "/segol2c": "\u05B6", "/segol:hb": "\u05B6", "/segolhebrew": "\u05B6", "/segolnarrowhebrew": "\u05B6", "/segolquarterhebrew": "\u05B6", "/segolta:hb": "\u0592", "/segoltahebrew": "\u0592", "/segolwidehebrew": "\u05B6", "/seharmenian": "\u057D", "/sehiragana": "\u305B", "/sekatakana": "\u30BB", "/sekatakanahalfwidth": "\uFF7E", "/selfideographicparen": "\u3242", "/semicolon": "\u003B", "/semicolonarabic": "\u061B", "/semicolonmonospace": "\uFF1B", "/semicolonreversed": "\u204F", "/semicolonsmall": "\uFE54", "/semicolonunderlinefunc": "\u236E", "/semidirectproductleft": "\u22CB", "/semidirectproductright": "\u22CC", "/semisextile": "\u26BA", "/semisoftcyr": "\u048D", "/semivoicedmarkkana": "\u309C", "/semivoicedmarkkanahalfwidth": "\uFF9F", "/sentisquare": "\u3322", "/sentosquare": "\u3323", "/septembertelegraph": "\u32C8", "/sersetdblup": "\u22D1", "/sersetnotequalup": "\u228B", "/servicemark": "\u2120", "/sesamedot": "\uFE45", "/sesquiquadrate": "\u26BC", "/setminus": "\u2216", "/seven": "\u0037", "/seven.inferior": "\u2087", "/seven.roman": "\u2166", "/seven.romansmall": "\u2176", "/seven.superior": "\u2077", "/sevenarabic": "\u0667", "/sevenbengali": "\u09ED", "/sevencircle": "\u2466", "/sevencircledbl": "\u24FB", "/sevencircleinversesansserif": "\u2790", "/sevencomma": "\u1F108", "/sevendeva": "\u096D", "/seveneighths": "\u215E", "/sevenfar": "\u06F7", "/sevengujarati": "\u0AED", "/sevengurmukhi": "\u0A6D", "/sevenhackarabic": "\u0667", "/sevenhangzhou": "\u3027", "/sevenideographiccircled": "\u3286", "/sevenideographicparen": "\u3226", "/seveninferior": "\u2087", "/sevenmonospace": "\uFF17", "/sevenoldstyle": "\uF737", "/sevenparen": "\u247A", "/sevenparenthesized": "\u247A", "/sevenperiod": "\u248E", "/sevenpersian": "\u06F7", "/sevenpointonesquare": "\u1F1A1", "/sevenroman": "\u2176", "/sevensuperior": "\u2077", "/seventeencircle": "\u2470", "/seventeencircleblack": "\u24F1", "/seventeenparen": "\u2484", "/seventeenparenthesized": "\u2484", "/seventeenperiod": "\u2498", "/seventhai": "\u0E57", "/seventycirclesquare": "\u324E", "/sextile": "\u26B9", "/sfthyphen": "\u00AD", "/shaarmenian": "\u0577", "/shabengali": "\u09B6", "/shacyr": "\u0448", "/shacyrillic": "\u0448", "/shaddaAlefIsol": "\uFC63", "/shaddaDammaIsol": "\uFC61", "/shaddaDammaMedi": "\uFCF3", "/shaddaDammatanIsol": "\uFC5E", "/shaddaFathaIsol": "\uFC60", "/shaddaFathaMedi": "\uFCF2", "/shaddaIsol": "\uFE7C", "/shaddaKasraIsol": "\uFC62", "/shaddaKasraMedi": "\uFCF4", "/shaddaKasratanIsol": "\uFC5F", "/shaddaMedi": "\uFE7D", "/shaddaarabic": "\u0651", "/shaddadammaarabic": "\uFC61", "/shaddadammatanarabic": "\uFC5E", "/shaddafathaarabic": "\uFC60", "/shaddafathatanarabic": "\u0651", "/shaddakasraarabic": "\uFC62", "/shaddakasratanarabic": "\uFC5F", "/shade": "\u2592", "/shadedark": "\u2593", "/shadelight": "\u2591", "/shademedium": "\u2592", "/shadeva": "\u0936", "/shagujarati": "\u0AB6", "/shagurmukhi": "\u0A36", "/shalshelet:hb": "\u0593", "/shalshelethebrew": "\u0593", "/shamrock": "\u2618", "/shavedIce": "\u1F367", "/shbopomofo": "\u3115", "/shchacyr": "\u0449", "/shchacyrillic": "\u0449", "/sheen": "\u0634", "/sheen.fina": "\uFEB6", "/sheen.init": "\uFEB7", "/sheen.init_alefmaksura.fina": "\uFCFD", "/sheen.init_hah.fina": "\uFD0A", "/sheen.init_hah.medi": "\uFD2E", "/sheen.init_hah.medi_meem.medi": "\uFD68", "/sheen.init_heh.medi": "\uFD32", "/sheen.init_jeem.fina": "\uFD09", "/sheen.init_jeem.medi": "\uFD2D", "/sheen.init_khah.fina": "\uFD0B", "/sheen.init_khah.medi": "\uFD2F", "/sheen.init_meem.fina": "\uFD0C", "/sheen.init_meem.medi": "\uFD30", "/sheen.init_meem.medi_khah.medi": "\uFD6B", "/sheen.init_meem.medi_meem.medi": "\uFD6D", "/sheen.init_reh.fina": "\uFD0D", "/sheen.init_yeh.fina": "\uFCFE", "/sheen.isol": "\uFEB5", "/sheen.medi": "\uFEB8", "/sheen.medi_alefmaksura.fina": "\uFD19", "/sheen.medi_hah.fina": "\uFD26", "/sheen.medi_hah.medi": "\uFD38", "/sheen.medi_hah.medi_meem.fina": "\uFD67", "/sheen.medi_hah.medi_yeh.fina": "\uFDAA", "/sheen.medi_heh.medi": "\uFCEA", "/sheen.medi_jeem.fina": "\uFD25", "/sheen.medi_jeem.medi": "\uFD37", "/sheen.medi_jeem.medi_yeh.fina": "\uFD69", "/sheen.medi_khah.fina": "\uFD27", "/sheen.medi_khah.medi": "\uFD39", "/sheen.medi_meem.fina": "\uFD28", "/sheen.medi_meem.medi": "\uFCE9", "/sheen.medi_meem.medi_khah.fina": "\uFD6A", "/sheen.medi_meem.medi_meem.fina": "\uFD6C", "/sheen.medi_reh.fina": "\uFD29", "/sheen.medi_yeh.fina": "\uFD1A", "/sheenarabic": "\u0634", "/sheendotbelow": "\u06FA", "/sheenfinalarabic": "\uFEB6", "/sheeninitialarabic": "\uFEB7", "/sheenmedialarabic": "\uFEB8", "/sheep": "\u1F411", "/sheicoptic": "\u03E3", "/shelfmod": "\u02FD", "/shelfopenmod": "\u02FE", "/sheqel": "\u20AA", "/sheqelhebrew": "\u20AA", "/sheva": "\u05B0", "/sheva115": "\u05B0", "/sheva15": "\u05B0", "/sheva22": "\u05B0", "/sheva2e": "\u05B0", "/sheva:hb": "\u05B0", "/shevahebrew": "\u05B0", "/shevanarrowhebrew": "\u05B0", "/shevaquarterhebrew": "\u05B0", "/shevawidehebrew": "\u05B0", "/shhacyr": "\u04BB", "/shhacyrillic": "\u04BB", "/shhatailcyr": "\u0527", "/shield": "\u1F6E1", "/shimacoptic": "\u03ED", "/shin": "\u05E9", "/shin:hb": "\u05E9", "/shinDot:hb": "\u05C1", "/shindagesh": "\uFB49", "/shindageshhebrew": "\uFB49", "/shindageshshindot": "\uFB2C", "/shindageshshindothebrew": "\uFB2C", "/shindageshsindot": "\uFB2D", "/shindageshsindothebrew": "\uFB2D", "/shindothebrew": "\u05C1", "/shinhebrew": "\u05E9", "/shinshindot": "\uFB2A", "/shinshindothebrew": "\uFB2A", "/shinsindot": "\uFB2B", "/shinsindothebrew": "\uFB2B", "/shintoshrine": "\u26E9", "/shinwithdagesh:hb": "\uFB49", "/shinwithdageshandshinDot:hb": "\uFB2C", "/shinwithdageshandsinDot:hb": "\uFB2D", "/shinwithshinDot:hb": "\uFB2A", "/shinwithsinDot:hb": "\uFB2B", "/ship": "\u1F6A2", "/sho": "\u03F8", "/shoejotupfunc": "\u235D", "/shoestiledownfunc": "\u2366", "/shoestileleftfunc": "\u2367", "/shogipieceblack": "\u2617", "/shogipiecewhite": "\u2616", "/shook": "\u0282", "/shootingStar": "\u1F320", "/shoppingBags": "\u1F6CD", "/shoppingTrolley": "\u1F6D2", "/shortcake": "\u1F370", "/shortequalsmod": "\uA78A", "/shortoverlongmetrical": "\u23D3", "/shoulderedopenbox": "\u237D", "/shower": "\u1F6BF", "/shvsquare": "\u1F1AA", "/sicirclekatakana": "\u32DB", "/sidewaysBlackDownPointingIndex": "\u1F5A1", "/sidewaysBlackLeftPointingIndex": "\u1F59A", "/sidewaysBlackRightPointingIndex": "\u1F59B", "/sidewaysBlackUpPointingIndex": "\u1F5A0", "/sidewaysWhiteDownPointingIndex": "\u1F59F", "/sidewaysWhiteLeftPointingIndex": "\u1F598", "/sidewaysWhiteRightPointingIndex": "\u1F599", "/sidewaysWhiteUpPointingIndex": "\u1F59E", "/sigma": "\u03C3", "/sigma1": "\u03C2", "/sigmafinal": "\u03C2", "/sigmalunatedottedreversedsymbol": "\u037D", "/sigmalunatedottedsymbol": "\u037C", "/sigmalunatereversedsymbol": "\u037B", "/sigmalunatesymbol": "\u03F2", "/sigmalunatesymbolgreek": "\u03F2", "/sihiragana": "\u3057", "/sikatakana": "\u30B7", "/sikatakanahalfwidth": "\uFF7C", "/silhouetteOfJapan": "\u1F5FE", "/siluqhebrew": "\u05BD", "/siluqlefthebrew": "\u05BD", "/similar": "\u223C", "/sinDot:hb": "\u05C2", "/sindothebrew": "\u05C2", "/sinewave": "\u223F", "/sinh:a": "\u0D85", "/sinh:aa": "\u0D86", "/sinh:aae": "\u0D88", "/sinh:aaesign": "\u0DD1", "/sinh:aasign": "\u0DCF", "/sinh:ae": "\u0D87", "/sinh:aesign": "\u0DD0", "/sinh:ai": "\u0D93", "/sinh:aisign": "\u0DDB", "/sinh:anusvara": "\u0D82", "/sinh:au": "\u0D96", "/sinh:ausign": "\u0DDE", "/sinh:ba": "\u0DB6", "/sinh:bha": "\u0DB7", "/sinh:ca": "\u0DA0", "/sinh:cha": "\u0DA1", "/sinh:da": "\u0DAF", "/sinh:dda": "\u0DA9", "/sinh:ddha": "\u0DAA", "/sinh:dha": "\u0DB0", "/sinh:e": "\u0D91", "/sinh:ee": "\u0D92", "/sinh:eesign": "\u0DDA", "/sinh:esign": "\u0DD9", "/sinh:fa": "\u0DC6", "/sinh:ga": "\u0D9C", "/sinh:gha": "\u0D9D", "/sinh:ha": "\u0DC4", "/sinh:i": "\u0D89", "/sinh:ii": "\u0D8A", "/sinh:iisign": "\u0DD3", "/sinh:isign": "\u0DD2", "/sinh:ja": "\u0DA2", "/sinh:jha": "\u0DA3", "/sinh:jnya": "\u0DA5", "/sinh:ka": "\u0D9A", "/sinh:kha": "\u0D9B", "/sinh:kunddaliya": "\u0DF4", "/sinh:la": "\u0DBD", "/sinh:litheight": "\u0DEE", "/sinh:lithfive": "\u0DEB", "/sinh:lithfour": "\u0DEA", "/sinh:lithnine": "\u0DEF", "/sinh:lithone": "\u0DE7", "/sinh:lithseven": "\u0DED", "/sinh:lithsix": "\u0DEC", "/sinh:liththree": "\u0DE9", "/sinh:lithtwo": "\u0DE8", "/sinh:lithzero": "\u0DE6", "/sinh:lla": "\u0DC5", "/sinh:llvocal": "\u0D90", "/sinh:llvocalsign": "\u0DF3", "/sinh:lvocal": "\u0D8F", "/sinh:lvocalsign": "\u0DDF", "/sinh:ma": "\u0DB8", "/sinh:mba": "\u0DB9", "/sinh:na": "\u0DB1", "/sinh:nda": "\u0DB3", "/sinh:nga": "\u0D9E", "/sinh:nna": "\u0DAB", "/sinh:nndda": "\u0DAC", "/sinh:nnga": "\u0D9F", "/sinh:nya": "\u0DA4", "/sinh:nyja": "\u0DA6", "/sinh:o": "\u0D94", "/sinh:oo": "\u0D95", "/sinh:oosign": "\u0DDD", "/sinh:osign": "\u0DDC", "/sinh:pa": "\u0DB4", "/sinh:pha": "\u0DB5", "/sinh:ra": "\u0DBB", "/sinh:rrvocal": "\u0D8E", "/sinh:rrvocalsign": "\u0DF2", "/sinh:rvocal": "\u0D8D", "/sinh:rvocalsign": "\u0DD8", "/sinh:sa": "\u0DC3", "/sinh:sha": "\u0DC1", "/sinh:ssa": "\u0DC2", "/sinh:ta": "\u0DAD", "/sinh:tha": "\u0DAE", "/sinh:tta": "\u0DA7", "/sinh:ttha": "\u0DA8", "/sinh:u": "\u0D8B", "/sinh:usign": "\u0DD4", "/sinh:uu": "\u0D8C", "/sinh:uusign": "\u0DD6", "/sinh:va": "\u0DC0", "/sinh:virama": "\u0DCA", "/sinh:visarga": "\u0D83", "/sinh:ya": "\u0DBA", "/sinologicaldot": "\uA78F", "/sinsular": "\uA785", "/siosacirclekorean": "\u3274", "/siosaparenkorean": "\u3214", "/sioscieuckorean": "\u317E", "/sioscirclekorean": "\u3266", "/sioskiyeokkorean": "\u317A", "/sioskorean": "\u3145", "/siosnieunkorean": "\u317B", "/siosparenkorean": "\u3206", "/siospieupkorean": "\u317D", "/siostikeutkorean": "\u317C", "/siringusquare": "\u3321", "/six": "\u0036", "/six.inferior": "\u2086", "/six.roman": "\u2165", "/six.romansmall": "\u2175", "/six.superior": "\u2076", "/sixPointedStarMiddleDot": "\u1F52F", "/sixarabic": "\u0666", "/sixbengali": "\u09EC", "/sixcircle": "\u2465", "/sixcircledbl": "\u24FA", "/sixcircleinversesansserif": "\u278F", "/sixcomma": "\u1F107", "/sixdeva": "\u096C", "/sixdotsvertical": "\u2E3D", "/sixfar": "\u06F6", "/sixgujarati": "\u0AEC", "/sixgurmukhi": "\u0A6C", "/sixhackarabic": "\u0666", "/sixhangzhou": "\u3026", "/sixideographiccircled": "\u3285", "/sixideographicparen": "\u3225", "/sixinferior": "\u2086", "/sixlateform.roman": "\u2185", "/sixmonospace": "\uFF16", "/sixoldstyle": "\uF736", "/sixparen": "\u2479", "/sixparenthesized": "\u2479", "/sixperemspace": "\u2006", "/sixperiod": "\u248D", "/sixpersian": "\u06F6", "/sixroman": "\u2175", "/sixsuperior": "\u2076", "/sixteencircle": "\u246F", "/sixteencircleblack": "\u24F0", "/sixteencurrencydenominatorbengali": "\u09F9", "/sixteenparen": "\u2483", "/sixteenparenthesized": "\u2483", "/sixteenperiod": "\u2497", "/sixthai": "\u0E56", "/sixtycirclesquare": "\u324D", "/sixtypsquare": "\u1F1A3", "/sjekomicyr": "\u050D", "/skiAndSkiBoot": "\u1F3BF", "/skier": "\u26F7", "/skull": "\u1F480", "/skullcrossbones": "\u2620", "/slash": "\u002F", "/slashbarfunc": "\u233F", "/slashmonospace": "\uFF0F", "/sled": "\u1F6F7", "/sleeping": "\u1F4A4", "/sleepingAccommodation": "\u1F6CC", "/sleepingFace": "\u1F634", "/sleepyFace": "\u1F62A", "/sleuthOrSpy": "\u1F575", "/sliceOfPizza": "\u1F355", "/slightlyFrowningFace": "\u1F641", "/slightlySmilingFace": "\u1F642", "/slong": "\u017F", "/slongdotaccent": "\u1E9B", "/slope": "\u2333", "/slotMachine": "\u1F3B0", "/smallAirplane": "\u1F6E9", "/smallBlueDiamond": "\u1F539", "/smallOrangeDiamond": "\u1F538", "/smallRedTriangleDOwn": "\u1F53D", "/smallRedTriangleUp": "\u1F53C", "/smile": "\u2323", "/smileface": "\u263A", "/smilingCatFaceWithHeartShapedEyes": "\u1F63B", "/smilingCatFaceWithOpenMouth": "\u1F63A", "/smilingFaceWithHalo": "\u1F607", "/smilingFaceWithHeartShapedEyes": "\u1F60D", "/smilingFaceWithHorns": "\u1F608", "/smilingFaceWithOpenMouth": "\u1F603", "/smilingFaceWithOpenMouthAndColdSweat": "\u1F605", "/smilingFaceWithOpenMouthAndSmilingEyes": "\u1F604", "/smilingFaceWithOpenMouthAndTightlyClosedEyes": "\u1F606", "/smilingFaceWithSmilingEyes": "\u1F60A", "/smilingFaceWithSunglasses": "\u1F60E", "/smilingfaceblack": "\u263B", "/smilingfacewhite": "\u263A", "/smirkingFace": "\u1F60F", "/smll:ampersand": "\uFE60", "/smll:asterisk": "\uFE61", "/smll:backslash": "\uFE68", "/smll:braceleft": "\uFE5B", "/smll:braceright": "\uFE5C", "/smll:colon": "\uFE55", "/smll:comma": "\uFE50", "/smll:dollar": "\uFE69", "/smll:emdash": "\uFE58", "/smll:equal": "\uFE66", "/smll:exclam": "\uFE57", "/smll:greater": "\uFE65", "/smll:hyphen": "\uFE63", "/smll:ideographiccomma": "\uFE51", "/smll:less": "\uFE64", "/smll:numbersign": "\uFE5F", "/smll:parenthesisleft": "\uFE59", "/smll:parenthesisright": "\uFE5A", "/smll:percent": "\uFE6A", "/smll:period": "\uFE52", "/smll:plus": "\uFE62", "/smll:question": "\uFE56", "/smll:semicolon": "\uFE54", "/smll:tortoiseshellbracketleft": "\uFE5D", "/smll:tortoiseshellbracketright": "\uFE5E", "/smoking": "\u1F6AC", "/smonospace": "\uFF53", "/snail": "\u1F40C", "/snake": "\u1F40D", "/snowboarder": "\u1F3C2", "/snowcappedMountain": "\u1F3D4", "/snowman": "\u2603", "/snowmanblack": "\u26C7", "/snowmanoutsnow": "\u26C4", "/sobliquestroke": "\uA7A9", "/soccerball": "\u26BD", "/societyideographiccircled": "\u3293", "/societyideographicparen": "\u3233", "/socirclekatakana": "\u32DE", "/sofPasuq:hb": "\u05C3", "/sofpasuqhebrew": "\u05C3", "/softIceCream": "\u1F366", "/softShellFloppyDisk": "\u1F5AC", "/softcyr": "\u044C", "/softhyphen": "\u00AD", "/softsigncyrillic": "\u044C", "/softwarefunction": "\u2394", "/sohiragana": "\u305D", "/sokatakana": "\u30BD", "/sokatakanahalfwidth": "\uFF7F", "/soliduslongoverlaycmb": "\u0338", "/solidusshortoverlaycmb": "\u0337", "/solidussubsetreversepreceding": "\u27C8", "/solidussupersetpreceding": "\u27C9", "/soonRightwardsArrowAbove": "\u1F51C", "/sorusithai": "\u0E29", "/sosalathai": "\u0E28", "/sosothai": "\u0E0B", "/sossquare": "\u1F198", "/sosuathai": "\u0E2A", "/soundcopyright": "\u2117", "/space": "\u0020", "/spacehackarabic": "\u0020", "/spade": "\u2660", "/spadeblack": "\u2660", "/spadesuitblack": "\u2660", "/spadesuitwhite": "\u2664", "/spadewhite": "\u2664", "/spaghetti": "\u1F35D", "/sparen": "\u24AE", "/sparenthesized": "\u24AE", "/sparklingHeart": "\u1F496", "/speakNoEvilMonkey": "\u1F64A", "/speaker": "\u1F508", "/speakerCancellationStroke": "\u1F507", "/speakerOneSoundWave": "\u1F509", "/speakerThreeSoundWaves": "\u1F50A", "/speakingHeadInSilhouette": "\u1F5E3", "/specialideographiccircled": "\u3295", "/specialideographicparen": "\u3235", "/speechBalloon": "\u1F4AC", "/speedboat": "\u1F6A4", "/spesmilo": "\u20B7", "/sphericalangle": "\u2222", "/spider": "\u1F577", "/spiderWeb": "\u1F578", "/spiralCalendarPad": "\u1F5D3", "/spiralNotePad": "\u1F5D2", "/spiralShell": "\u1F41A", "/splashingSweat": "\u1F4A6", "/sportsMedal": "\u1F3C5", "/spoutingWhale": "\u1F433", "/sppl:tildevertical": "\u2E2F", "/squarebelowcmb": "\u033B", "/squareblack": "\u25A0", "/squarebracketleftvertical": "\uFE47", "/squarebracketrightvertical": "\uFE48", "/squarecap": "\u2293", "/squarecc": "\u33C4", "/squarecm": "\u339D", "/squarecup": "\u2294", "/squareddotoperator": "\u22A1", "/squarediagonalcrosshatchfill": "\u25A9", "/squaredj": "\u1F190", "/squaredkey": "\u26BF", "/squaredminus": "\u229F", "/squaredplus": "\u229E", "/squaredsaltire": "\u26DD", "/squaredtimes": "\u22A0", "/squarefourcorners": "\u26F6", "/squarehalfleftblack": "\u25E7", "/squarehalfrightblack": "\u25E8", "/squarehorizontalfill": "\u25A4", "/squareimage": "\u228F", "/squareimageorequal": "\u2291", "/squareimageornotequal": "\u22E4", "/squarekg": "\u338F", "/squarekm": "\u339E", "/squarekmcapital": "\u33CE", "/squareln": "\u33D1", "/squarelog": "\u33D2", "/squarelowerdiagonalhalfrightblack": "\u25EA", "/squaremediumblack": "\u25FC", "/squaremediumwhite": "\u25FB", "/squaremg": "\u338E", "/squaremil": "\u33D5", "/squaremm": "\u339C", "/squaremsquared": "\u33A1", "/squareoriginal": "\u2290", "/squareoriginalorequal": "\u2292", "/squareoriginalornotequal": "\u22E5", "/squareorthogonalcrosshatchfill": "\u25A6", "/squareraised": "\u2E0B", "/squaresmallblack": "\u25AA", "/squaresmallmediumblack": "\u25FE", "/squaresmallmediumwhite": "\u25FD", "/squaresmallwhite": "\u25AB", "/squareupperdiagonalhalfleftblack": "\u25E9", "/squareupperlefttolowerrightfill": "\u25A7", "/squareupperrighttolowerleftfill": "\u25A8", "/squareverticalfill": "\u25A5", "/squarewhite": "\u25A1", "/squarewhitebisectinglinevertical": "\u25EB", "/squarewhitelowerquadrantleft": "\u25F1", "/squarewhitelowerquadrantright": "\u25F2", "/squarewhiteround": "\u25A2", "/squarewhiteupperquadrantleft": "\u25F0", "/squarewhiteupperquadrantright": "\u25F3", "/squarewhitewithsmallblack": "\u25A3", "/squarewhitewithsquaresmallblack": "\u25A3", "/squishquadfunc": "\u2337", "/srfullwidth": "\u33DB", "/srsquare": "\u33DB", "/ssabengali": "\u09B7", "/ssadeva": "\u0937", "/ssagujarati": "\u0AB7", "/ssangcieuckorean": "\u3149", "/ssanghieuhkorean": "\u3185", "/ssangieungkorean": "\u3180", "/ssangkiyeokkorean": "\u3132", "/ssangnieunkorean": "\u3165", "/ssangpieupkorean": "\u3143", "/ssangsioskorean": "\u3146", "/ssangtikeutkorean": "\u3138", "/ssuperior": "\uF6F2", "/ssupmod": "\u02E2", "/sswashtail": "\u023F", "/stackedcommadbl": "\u2E49", "/stadium": "\u1F3DF", "/staffofaesculapius": "\u2695", "/staffofhermes": "\u269A", "/stampedEnvelope": "\u1F583", "/star": "\u22C6", "/starblack": "\u2605", "/starcrescent": "\u262A", "/stardiaeresisfunc": "\u2363", "/starequals": "\u225B", "/staroperator": "\u22C6", "/staroutlinedwhite": "\u269D", "/starwhite": "\u2606", "/station": "\u1F689", "/statueOfLiberty": "\u1F5FD", "/steamLocomotive": "\u1F682", "/steamingBowl": "\u1F35C", "/stenographicfullstop": "\u2E3C", "/sterling": "\u00A3", "/sterlingmonospace": "\uFFE1", "/stigma": "\u03DB", "/stiletildefunc": "\u236D", "/stockChart": "\u1F5E0", "/stockideographiccircled": "\u3291", "/stockideographicparen": "\u3231", "/stopabove": "\u06EB", "/stopbelow": "\u06EA", "/straightRuler": "\u1F4CF", "/straightness": "\u23E4", "/strawberry": "\u1F353", "/stresslowtonemod": "\uA721", "/stresstonemod": "\uA720", "/strictlyequivalent": "\u2263", "/strokelongoverlaycmb": "\u0336", "/strokeshortoverlaycmb": "\u0335", "/studioMicrophone": "\u1F399", "/studyideographiccircled": "\u32AB", "/studyideographicparen": "\u323B", "/stupa": "\u1F6D3", "/subscriptalef": "\u0656", "/subset": "\u2282", "/subsetdbl": "\u22D0", "/subsetnotequal": "\u228A", "/subsetorequal": "\u2286", "/succeeds": "\u227B", "/succeedsbutnotequivalent": "\u22E9", "/succeedsorequal": "\u227D", "/succeedsorequivalent": "\u227F", "/succeedsunderrelation": "\u22B1", "/suchthat": "\u220B", "/sucirclekatakana": "\u32DC", "/suhiragana": "\u3059", "/suitableideographiccircled": "\u329C", "/sukatakana": "\u30B9", "/sukatakanahalfwidth": "\uFF7D", "/sukumendutvowel": "\uA9B9", "/sukunIsol": "\uFE7E", "/sukunMedi": "\uFE7F", "/sukunarabic": "\u0652", "/sukuvowel": "\uA9B8", "/summation": "\u2211", "/summationbottom": "\u23B3", "/summationdblstruck": "\u2140", "/summationtop": "\u23B2", "/sun": "\u263C", "/sunFace": "\u1F31E", "/sunbehindcloud": "\u26C5", "/sunflower": "\u1F33B", "/sunideographiccircled": "\u3290", "/sunideographicparen": "\u3230", "/sunraysblack": "\u2600", "/sunrayswhite": "\u263C", "/sunrise": "\u1F305", "/sunriseOverMountains": "\u1F304", "/sunsetOverBuildings": "\u1F307", "/superset": "\u2283", "/supersetnotequal": "\u228B", "/supersetorequal": "\u2287", "/superviseideographiccircled": "\u32AC", "/superviseideographicparen": "\u323C", "/surfer": "\u1F3C4", "/sushi": "\u1F363", "/suspensionRailway": "\u1F69F", "/suspensiondbl": "\u2E44", "/svfullwidth": "\u33DC", "/svsquare": "\u33DC", "/swatchtop": "\u23F1", "/swimmer": "\u1F3CA", "/swungdash": "\u2053", "/symbolabovethreedotsabove": "\uFBB6", "/symbolbelowthreedotsabove": "\uFBB7", "/symboldotabove": "\uFBB2", "/symboldotbelow": "\uFBB3", "/symboldoubleverticalbarbelow": "\uFBBC", "/symbolfourdotsabove": "\uFBBA", "/symbolfourdotsbelow": "\uFBBB", "/symbolpointingabovedownthreedotsabove": "\uFBB8", "/symbolpointingbelowdownthreedotsabove": "\uFBB9", "/symbolring": "\uFBBF", "/symboltahabovesmall": "\uFBC0", "/symboltahbelowsmall": "\uFBC1", "/symboltwodotsabove": "\uFBB4", "/symboltwodotsbelow": "\uFBB5", "/symboltwodotsverticallyabove": "\uFBBD", "/symboltwodotsverticallybelow": "\uFBBE", "/symmetry": "\u232F", "/synagogue": "\u1F54D", "/syouwaerasquare": "\u337C", "/syringe": "\u1F489", "/t": "\u0074", "/t-shirt": "\u1F455", "/t.inferior": "\u209C", "/tabengali": "\u09A4", "/tableTennisPaddleAndBall": "\u1F3D3", "/tacirclekatakana": "\u32DF", "/tackcircleaboveup": "\u27DF", "/tackdiaeresisupfunc": "\u2361", "/tackdown": "\u22A4", "/tackdownmod": "\u02D5", "/tackjotdownfunc": "\u234E", "/tackjotupfunc": "\u2355", "/tackleft": "\u22A3", "/tackleftright": "\u27DB", "/tackoverbarupfunc": "\u2351", "/tackright": "\u22A2", "/tackunderlinedownfunc": "\u234A", "/tackup": "\u22A5", "/tackupmod": "\u02D4", "/taco": "\u1F32E", "/tadeva": "\u0924", "/tagujarati": "\u0AA4", "/tagurmukhi": "\u0A24", "/tah": "\u0637", "/tah.fina": "\uFEC2", "/tah.init": "\uFEC3", "/tah.init_alefmaksura.fina": "\uFCF5", "/tah.init_hah.fina": "\uFC26", "/tah.init_hah.medi": "\uFCB8", "/tah.init_meem.fina": "\uFC27", "/tah.init_meem.medi": "\uFD33", "/tah.init_meem.medi_hah.medi": "\uFD72", "/tah.init_meem.medi_meem.medi": "\uFD73", "/tah.init_yeh.fina": "\uFCF6", "/tah.isol": "\uFEC1", "/tah.medi": "\uFEC4", "/tah.medi_alefmaksura.fina": "\uFD11", "/tah.medi_meem.medi": "\uFD3A", "/tah.medi_meem.medi_hah.fina": "\uFD71", "/tah.medi_meem.medi_yeh.fina": "\uFD74", "/tah.medi_yeh.fina": "\uFD12", "/tahabove": "\u0615", "/taharabic": "\u0637", "/tahfinalarabic": "\uFEC2", "/tahinitialarabic": "\uFEC3", "/tahiragana": "\u305F", "/tahmedialarabic": "\uFEC4", "/tahthreedotsabove": "\u069F", "/taisyouerasquare": "\u337D", "/takatakana": "\u30BF", "/takatakanahalfwidth": "\uFF80", "/takhallus": "\u0614", "/talingvowel": "\uA9BA", "/taml:a": "\u0B85", "/taml:aa": "\u0B86", "/taml:aasign": "\u0BBE", "/taml:ai": "\u0B90", "/taml:aisign": "\u0BC8", "/taml:anusvarasign": "\u0B82", "/taml:asabovesign": "\u0BF8", "/taml:au": "\u0B94", "/taml:aulengthmark": "\u0BD7", "/taml:ausign": "\u0BCC", "/taml:ca": "\u0B9A", "/taml:creditsign": "\u0BF7", "/taml:daysign": "\u0BF3", "/taml:debitsign": "\u0BF6", "/taml:e": "\u0B8E", "/taml:ee": "\u0B8F", "/taml:eesign": "\u0BC7", "/taml:eight": "\u0BEE", "/taml:esign": "\u0BC6", "/taml:five": "\u0BEB", "/taml:four": "\u0BEA", "/taml:ha": "\u0BB9", "/taml:i": "\u0B87", "/taml:ii": "\u0B88", "/taml:iisign": "\u0BC0", "/taml:isign": "\u0BBF", "/taml:ja": "\u0B9C", "/taml:ka": "\u0B95", "/taml:la": "\u0BB2", "/taml:lla": "\u0BB3", "/taml:llla": "\u0BB4", "/taml:ma": "\u0BAE", "/taml:monthsign": "\u0BF4", "/taml:na": "\u0BA8", "/taml:nga": "\u0B99", "/taml:nine": "\u0BEF", "/taml:nna": "\u0BA3", "/taml:nnna": "\u0BA9", "/taml:nya": "\u0B9E", "/taml:o": "\u0B92", "/taml:om": "\u0BD0", "/taml:one": "\u0BE7", "/taml:onehundred": "\u0BF1", "/taml:onethousand": "\u0BF2", "/taml:oo": "\u0B93", "/taml:oosign": "\u0BCB", "/taml:osign": "\u0BCA", "/taml:pa": "\u0BAA", "/taml:ra": "\u0BB0", "/taml:rra": "\u0BB1", "/taml:rupeesign": "\u0BF9", "/taml:sa": "\u0BB8", "/taml:seven": "\u0BED", "/taml:sha": "\u0BB6", "/taml:sign": "\u0BFA", "/taml:six": "\u0BEC", "/taml:ssa": "\u0BB7", "/taml:ta": "\u0BA4", "/taml:ten": "\u0BF0", "/taml:three": "\u0BE9", "/taml:tta": "\u0B9F", "/taml:two": "\u0BE8", "/taml:u": "\u0B89", "/taml:usign": "\u0BC1", "/taml:uu": "\u0B8A", "/taml:uusign": "\u0BC2", "/taml:va": "\u0BB5", "/taml:viramasign": "\u0BCD", "/taml:visargasign": "\u0B83", "/taml:ya": "\u0BAF", "/taml:yearsign": "\u0BF5", "/taml:zero": "\u0BE6", "/tamurda": "\uA9A1", "/tanabataTree": "\u1F38B", "/tangerine": "\u1F34A", "/tapeCartridge": "\u1F5AD", "/tarungvowel": "\uA9B4", "/tatweelFathatanAbove": "\uFE71", "/tatweelarabic": "\u0640", "/tau": "\u03C4", "/taurus": "\u2649", "/tav": "\u05EA", "/tav:hb": "\u05EA", "/tavdages": "\uFB4A", "/tavdagesh": "\uFB4A", "/tavdageshhebrew": "\uFB4A", "/tavhebrew": "\u05EA", "/tavwide:hb": "\uFB28", "/tavwithdagesh:hb": "\uFB4A", "/taxi": "\u1F695", "/tbar": "\u0167", "/tbopomofo": "\u310A", "/tcaron": "\u0165", "/tccurl": "\u02A8", "/tcedilla": "\u0163", "/tcheh": "\u0686", "/tcheh.fina": "\uFB7B", "/tcheh.init": "\uFB7C", "/tcheh.isol": "\uFB7A", "/tcheh.medi": "\uFB7D", "/tcheharabic": "\u0686", "/tchehdotabove": "\u06BF", "/tcheheh": "\u0687", "/tcheheh.fina": "\uFB7F", "/tcheheh.init": "\uFB80", "/tcheheh.isol": "\uFB7E", "/tcheheh.medi": "\uFB81", "/tchehfinalarabic": "\uFB7B", "/tchehinitialarabic": "\uFB7C", "/tchehmedialarabic": "\uFB7D", "/tchehmeeminitialarabic": "\uFB7C", "/tcircle": "\u24E3", "/tcircumflexbelow": "\u1E71", "/tcommaaccent": "\u0163", "/tcurl": "\u0236", "/tdieresis": "\u1E97", "/tdot": "\u1E6B", "/tdotaccent": "\u1E6B", "/tdotbelow": "\u1E6D", "/teacupOutHandle": "\u1F375", "/tear-offCalendar": "\u1F4C6", "/tecirclekatakana": "\u32E2", "/tecyr": "\u0442", "/tecyrillic": "\u0442", "/tedescendercyrillic": "\u04AD", "/teh": "\u062A", "/teh.fina": "\uFE96", "/teh.init": "\uFE97", "/teh.init_alefmaksura.fina": "\uFC0F", "/teh.init_hah.fina": "\uFC0C", "/teh.init_hah.medi": "\uFCA2", "/teh.init_hah.medi_jeem.medi": "\uFD52", "/teh.init_hah.medi_meem.medi": "\uFD53", "/teh.init_heh.medi": "\uFCA5", "/teh.init_jeem.fina": "\uFC0B", "/teh.init_jeem.medi": "\uFCA1", "/teh.init_jeem.medi_meem.medi": "\uFD50", "/teh.init_khah.fina": "\uFC0D", "/teh.init_khah.medi": "\uFCA3", "/teh.init_khah.medi_meem.medi": "\uFD54", "/teh.init_meem.fina": "\uFC0E", "/teh.init_meem.medi": "\uFCA4", "/teh.init_meem.medi_hah.medi": "\uFD56", "/teh.init_meem.medi_jeem.medi": "\uFD55", "/teh.init_meem.medi_khah.medi": "\uFD57", "/teh.init_yeh.fina": "\uFC10", "/teh.isol": "\uFE95", "/teh.medi": "\uFE98", "/teh.medi_alefmaksura.fina": "\uFC74", "/teh.medi_hah.medi_jeem.fina": "\uFD51", "/teh.medi_heh.medi": "\uFCE4", "/teh.medi_jeem.medi_alefmaksura.fina": "\uFDA0", "/teh.medi_jeem.medi_yeh.fina": "\uFD9F", "/teh.medi_khah.medi_alefmaksura.fina": "\uFDA2", "/teh.medi_khah.medi_yeh.fina": "\uFDA1", "/teh.medi_meem.fina": "\uFC72", "/teh.medi_meem.medi": "\uFCE3", "/teh.medi_meem.medi_alefmaksura.fina": "\uFDA4", "/teh.medi_meem.medi_yeh.fina": "\uFDA3", "/teh.medi_noon.fina": "\uFC73", "/teh.medi_reh.fina": "\uFC70", "/teh.medi_yeh.fina": "\uFC75", "/teh.medi_zain.fina": "\uFC71", "/teharabic": "\u062A", "/tehdownthreedotsabove": "\u067D", "/teheh": "\u067F", "/teheh.fina": "\uFB63", "/teheh.init": "\uFB64", "/teheh.isol": "\uFB62", "/teheh.medi": "\uFB65", "/tehfinalarabic": "\uFE96", "/tehhahinitialarabic": "\uFCA2", "/tehhahisolatedarabic": "\uFC0C", "/tehinitialarabic": "\uFE97", "/tehiragana": "\u3066", "/tehjeeminitialarabic": "\uFCA1", "/tehjeemisolatedarabic": "\uFC0B", "/tehmarbuta": "\u0629", "/tehmarbuta.fina": "\uFE94", "/tehmarbuta.isol": "\uFE93", "/tehmarbutaarabic": "\u0629", "/tehmarbutafinalarabic": "\uFE94", "/tehmarbutagoal": "\u06C3", "/tehmedialarabic": "\uFE98", "/tehmeeminitialarabic": "\uFCA4", "/tehmeemisolatedarabic": "\uFC0E", "/tehnoonfinalarabic": "\uFC73", "/tehring": "\u067C", "/tekatakana": "\u30C6", "/tekatakanahalfwidth": "\uFF83", "/telephone": "\u2121", "/telephoneOnTopOfModem": "\u1F580", "/telephoneReceiver": "\u1F4DE", "/telephoneReceiverPage": "\u1F57C", "/telephoneblack": "\u260E", "/telephonerecorder": "\u2315", "/telephonewhite": "\u260F", "/telescope": "\u1F52D", "/television": "\u1F4FA", "/telishaGedolah:hb": "\u05A0", "/telishaQetannah:hb": "\u05A9", "/telishagedolahebrew": "\u05A0", "/telishaqetanahebrew": "\u05A9", "/telu:a": "\u0C05", "/telu:aa": "\u0C06", "/telu:aasign": "\u0C3E", "/telu:ai": "\u0C10", "/telu:ailengthmark": "\u0C56", "/telu:aisign": "\u0C48", "/telu:anusvarasign": "\u0C02", "/telu:au": "\u0C14", "/telu:ausign": "\u0C4C", "/telu:avagrahasign": "\u0C3D", "/telu:ba": "\u0C2C", "/telu:bha": "\u0C2D", "/telu:bindusigncandra": "\u0C01", "/telu:ca": "\u0C1A", "/telu:cha": "\u0C1B", "/telu:combiningbinduabovesigncandra": "\u0C00", "/telu:da": "\u0C26", "/telu:dda": "\u0C21", "/telu:ddha": "\u0C22", "/telu:dha": "\u0C27", "/telu:dza": "\u0C59", "/telu:e": "\u0C0E", "/telu:ee": "\u0C0F", "/telu:eesign": "\u0C47", "/telu:eight": "\u0C6E", "/telu:esign": "\u0C46", "/telu:five": "\u0C6B", "/telu:four": "\u0C6A", "/telu:fractiononeforevenpowersoffour": "\u0C7C", "/telu:fractiononeforoddpowersoffour": "\u0C79", "/telu:fractionthreeforevenpowersoffour": "\u0C7E", "/telu:fractionthreeforoddpowersoffour": "\u0C7B", "/telu:fractiontwoforevenpowersoffour": "\u0C7D", "/telu:fractiontwoforoddpowersoffour": "\u0C7A", "/telu:fractionzeroforoddpowersoffour": "\u0C78", "/telu:ga": "\u0C17", "/telu:gha": "\u0C18", "/telu:ha": "\u0C39", "/telu:i": "\u0C07", "/telu:ii": "\u0C08", "/telu:iisign": "\u0C40", "/telu:isign": "\u0C3F", "/telu:ja": "\u0C1C", "/telu:jha": "\u0C1D", "/telu:ka": "\u0C15", "/telu:kha": "\u0C16", "/telu:la": "\u0C32", "/telu:lengthmark": "\u0C55", "/telu:lla": "\u0C33", "/telu:llla": "\u0C34", "/telu:llsignvocal": "\u0C63", "/telu:llvocal": "\u0C61", "/telu:lsignvocal": "\u0C62", "/telu:lvocal": "\u0C0C", "/telu:ma": "\u0C2E", "/telu:na": "\u0C28", "/telu:nga": "\u0C19", "/telu:nine": "\u0C6F", "/telu:nna": "\u0C23", "/telu:nya": "\u0C1E", "/telu:o": "\u0C12", "/telu:one": "\u0C67", "/telu:oo": "\u0C13", "/telu:oosign": "\u0C4B", "/telu:osign": "\u0C4A", "/telu:pa": "\u0C2A", "/telu:pha": "\u0C2B", "/telu:ra": "\u0C30", "/telu:rra": "\u0C31", "/telu:rrra": "\u0C5A", "/telu:rrsignvocal": "\u0C44", "/telu:rrvocal": "\u0C60", "/telu:rsignvocal": "\u0C43", "/telu:rvocal": "\u0C0B", "/telu:sa": "\u0C38", "/telu:seven": "\u0C6D", "/telu:sha": "\u0C36", "/telu:six": "\u0C6C", "/telu:ssa": "\u0C37", "/telu:ta": "\u0C24", "/telu:tha": "\u0C25", "/telu:three": "\u0C69", "/telu:tsa": "\u0C58", "/telu:tta": "\u0C1F", "/telu:ttha": "\u0C20", "/telu:tuumusign": "\u0C7F", "/telu:two": "\u0C68", "/telu:u": "\u0C09", "/telu:usign": "\u0C41", "/telu:uu": "\u0C0A", "/telu:uusign": "\u0C42", "/telu:va": "\u0C35", "/telu:viramasign": "\u0C4D", "/telu:visargasign": "\u0C03", "/telu:ya": "\u0C2F", "/telu:zero": "\u0C66", "/ten.roman": "\u2169", "/ten.romansmall": "\u2179", "/tencircle": "\u2469", "/tencircledbl": "\u24FE", "/tencirclesquare": "\u3248", "/tenge": "\u20B8", "/tenhangzhou": "\u3038", "/tenideographiccircled": "\u3289", "/tenideographicparen": "\u3229", "/tennisRacquetAndBall": "\u1F3BE", "/tenparen": "\u247D", "/tenparenthesized": "\u247D", "/tenperiod": "\u2491", "/tenroman": "\u2179", "/tent": "\u26FA", "/tenthousand.roman": "\u2182", "/tesh": "\u02A7", "/tet": "\u05D8", "/tet:hb": "\u05D8", "/tetailcyr": "\u04AD", "/tetdagesh": "\uFB38", "/tetdageshhebrew": "\uFB38", "/tethebrew": "\u05D8", "/tetrasememetrical": "\u23D8", "/tetsecyr": "\u04B5", "/tetsecyrillic": "\u04B5", "/tetwithdagesh:hb": "\uFB38", "/tevir:hb": "\u059B", "/tevirhebrew": "\u059B", "/tevirlefthebrew": "\u059B", "/thabengali": "\u09A5", "/thadeva": "\u0925", "/thagujarati": "\u0AA5", "/thagurmukhi": "\u0A25", "/thai:angkhankhu": "\u0E5A", "/thai:baht": "\u0E3F", "/thai:bobaimai": "\u0E1A", "/thai:chochan": "\u0E08", "/thai:chochang": "\u0E0A", "/thai:choching": "\u0E09", "/thai:chochoe": "\u0E0C", "/thai:dochada": "\u0E0E", "/thai:dodek": "\u0E14", "/thai:eight": "\u0E58", "/thai:five": "\u0E55", "/thai:fofa": "\u0E1D", "/thai:fofan": "\u0E1F", "/thai:fongman": "\u0E4F", "/thai:four": "\u0E54", "/thai:hohip": "\u0E2B", "/thai:honokhuk": "\u0E2E", "/thai:khokhai": "\u0E02", "/thai:khokhon": "\u0E05", "/thai:khokhuat": "\u0E03", "/thai:khokhwai": "\u0E04", "/thai:khomut": "\u0E5B", "/thai:khorakhang": "\u0E06", "/thai:kokai": "\u0E01", "/thai:lakkhangyao": "\u0E45", "/thai:lochula": "\u0E2C", "/thai:loling": "\u0E25", "/thai:lu": "\u0E26", "/thai:maichattawa": "\u0E4B", "/thai:maiek": "\u0E48", "/thai:maihan-akat": "\u0E31", "/thai:maitaikhu": "\u0E47", "/thai:maitho": "\u0E49", "/thai:maitri": "\u0E4A", "/thai:maiyamok": "\u0E46", "/thai:moma": "\u0E21", "/thai:ngongu": "\u0E07", "/thai:nikhahit": "\u0E4D", "/thai:nine": "\u0E59", "/thai:nonen": "\u0E13", "/thai:nonu": "\u0E19", "/thai:oang": "\u0E2D", "/thai:one": "\u0E51", "/thai:paiyannoi": "\u0E2F", "/thai:phinthu": "\u0E3A", "/thai:phophan": "\u0E1E", "/thai:phophung": "\u0E1C", "/thai:phosamphao": "\u0E20", "/thai:popla": "\u0E1B", "/thai:rorua": "\u0E23", "/thai:ru": "\u0E24", "/thai:saraa": "\u0E30", "/thai:saraaa": "\u0E32", "/thai:saraae": "\u0E41", "/thai:saraaimaimalai": "\u0E44", "/thai:saraaimaimuan": "\u0E43", "/thai:saraam": "\u0E33", "/thai:sarae": "\u0E40", "/thai:sarai": "\u0E34", "/thai:saraii": "\u0E35", "/thai:sarao": "\u0E42", "/thai:sarau": "\u0E38", "/thai:saraue": "\u0E36", "/thai:sarauee": "\u0E37", "/thai:sarauu": "\u0E39", "/thai:seven": "\u0E57", "/thai:six": "\u0E56", "/thai:sorusi": "\u0E29", "/thai:sosala": "\u0E28", "/thai:soso": "\u0E0B", "/thai:sosua": "\u0E2A", "/thai:thanthakhat": "\u0E4C", "/thai:thonangmontho": "\u0E11", "/thai:thophuthao": "\u0E12", "/thai:thothahan": "\u0E17", "/thai:thothan": "\u0E10", "/thai:thothong": "\u0E18", "/thai:thothung": "\u0E16", "/thai:three": "\u0E53", "/thai:topatak": "\u0E0F", "/thai:totao": "\u0E15", "/thai:two": "\u0E52", "/thai:wowaen": "\u0E27", "/thai:yamakkan": "\u0E4E", "/thai:yoyak": "\u0E22", "/thai:yoying": "\u0E0D", "/thai:zero": "\u0E50", "/thal": "\u0630", "/thal.fina": "\uFEAC", "/thal.init_superscriptalef.fina": "\uFC5B", "/thal.isol": "\uFEAB", "/thalarabic": "\u0630", "/thalfinalarabic": "\uFEAC", "/thanthakhatlowleftthai": "\uF898", "/thanthakhatlowrightthai": "\uF897", "/thanthakhatthai": "\u0E4C", "/thanthakhatupperleftthai": "\uF896", "/theh": "\u062B", "/theh.fina": "\uFE9A", "/theh.init": "\uFE9B", "/theh.init_alefmaksura.fina": "\uFC13", "/theh.init_jeem.fina": "\uFC11", "/theh.init_meem.fina": "\uFC12", "/theh.init_meem.medi": "\uFCA6", "/theh.init_yeh.fina": "\uFC14", "/theh.isol": "\uFE99", "/theh.medi": "\uFE9C", "/theh.medi_alefmaksura.fina": "\uFC7A", "/theh.medi_heh.medi": "\uFCE6", "/theh.medi_meem.fina": "\uFC78", "/theh.medi_meem.medi": "\uFCE5", "/theh.medi_noon.fina": "\uFC79", "/theh.medi_reh.fina": "\uFC76", "/theh.medi_yeh.fina": "\uFC7B", "/theh.medi_zain.fina": "\uFC77", "/theharabic": "\u062B", "/thehfinalarabic": "\uFE9A", "/thehinitialarabic": "\uFE9B", "/thehmedialarabic": "\uFE9C", "/thereexists": "\u2203", "/therefore": "\u2234", "/thermometer": "\u1F321", "/theta": "\u03B8", "/theta.math": "\u03D1", "/theta1": "\u03D1", "/thetasymbolgreek": "\u03D1", "/thieuthacirclekorean": "\u3279", "/thieuthaparenkorean": "\u3219", "/thieuthcirclekorean": "\u326B", "/thieuthkorean": "\u314C", "/thieuthparenkorean": "\u320B", "/thinspace": "\u2009", "/thirteencircle": "\u246C", "/thirteencircleblack": "\u24ED", "/thirteenparen": "\u2480", "/thirteenparenthesized": "\u2480", "/thirteenperiod": "\u2494", "/thirtycircle": "\u325A", "/thirtycirclesquare": "\u324A", "/thirtyeightcircle": "\u32B3", "/thirtyfivecircle": "\u325F", "/thirtyfourcircle": "\u325E", "/thirtyhangzhou": "\u303A", "/thirtyninecircle": "\u32B4", "/thirtyonecircle": "\u325B", "/thirtysevencircle": "\u32B2", "/thirtysixcircle": "\u32B1", "/thirtythreecircle": "\u325D", "/thirtytwocircle": "\u325C", "/thonangmonthothai": "\u0E11", "/thook": "\u01AD", "/thophuthaothai": "\u0E12", "/thorn": "\u00FE", "/thornstroke": "\uA765", "/thornstrokedescender": "\uA767", "/thothahanthai": "\u0E17", "/thothanthai": "\u0E10", "/thothongthai": "\u0E18", "/thothungthai": "\u0E16", "/thoughtBalloon": "\u1F4AD", "/thousandcyrillic": "\u0482", "/thousandscyr": "\u0482", "/thousandsseparator": "\u066C", "/thousandsseparatorarabic": "\u066C", "/thousandsseparatorpersian": "\u066C", "/three": "\u0033", "/three.inferior": "\u2083", "/three.roman": "\u2162", "/three.romansmall": "\u2172", "/threeButtonMouse": "\u1F5B1", "/threeNetworkedComputers": "\u1F5A7", "/threeRaysAbove": "\u1F5E4", "/threeRaysBelow": "\u1F5E5", "/threeRaysLeft": "\u1F5E6", "/threeRaysRight": "\u1F5E7", "/threeSpeechBubbles": "\u1F5EB", "/threearabic": "\u0663", "/threebengali": "\u09E9", "/threecircle": "\u2462", "/threecircledbl": "\u24F7", "/threecircleinversesansserif": "\u278C", "/threecomma": "\u1F104", "/threedeva": "\u0969", "/threedimensionalangle": "\u27C0", "/threedotpunctuation": "\u2056", "/threedotsaboveabove": "\u06DB", "/threedsquare": "\u1F19B", "/threeeighths": "\u215C", "/threefar": "\u06F3", "/threefifths": "\u2157", "/threegujarati": "\u0AE9", "/threegurmukhi": "\u0A69", "/threehackarabic": "\u0663", "/threehangzhou": "\u3023", "/threeideographiccircled": "\u3282", "/threeideographicparen": "\u3222", "/threeinferior": "\u2083", "/threelinesconvergingleft": "\u269F", "/threelinesconvergingright": "\u269E", "/threemonospace": "\uFF13", "/threenumeratorbengali": "\u09F6", "/threeoldstyle": "\uF733", "/threeparen": "\u2476", "/threeparenthesized": "\u2476", "/threeperemspace": "\u2004", "/threeperiod": "\u248A", "/threepersian": "\u06F3", "/threequarters": "\u00BE", "/threequartersemdash": "\uF6DE", "/threerightarrows": "\u21F6", "/threeroman": "\u2172", "/threesuperior": "\u00B3", "/threethai": "\u0E53", "/thumbsDownSign": "\u1F44E", "/thumbsUpSign": "\u1F44D", "/thundercloudrain": "\u26C8", "/thunderstorm": "\u2608", "/thzfullwidth": "\u3394", "/thzsquare": "\u3394", "/tibt:AA": "\u0F60", "/tibt:a": "\u0F68", "/tibt:aavowelsign": "\u0F71", "/tibt:angkhanggyasmark": "\u0F3D", "/tibt:angkhanggyonmark": "\u0F3C", "/tibt:astrologicalkhyudpasign": "\u0F18", "/tibt:astrologicalsdongtshugssign": "\u0F19", "/tibt:astrologicalsgragcancharrtagssign": "\u0F17", "/tibt:asubjoined": "\u0FB8", "/tibt:ba": "\u0F56", "/tibt:basubjoined": "\u0FA6", "/tibt:bha": "\u0F57", "/tibt:bhasubjoined": "\u0FA7", "/tibt:bkashogyigmgomark": "\u0F0A", "/tibt:brdarnyingyigmgomdunmainitialmark": "\u0FD3", "/tibt:brdarnyingyigmgosgabmaclosingmark": "\u0FD4", "/tibt:bsdusrtagsmark": "\u0F34", "/tibt:bskashoggimgorgyanmark": "\u0FD0", "/tibt:bskuryigmgomark": "\u0F09", "/tibt:ca": "\u0F45", "/tibt:cangteucantillationsign": "\u0FC2", "/tibt:caretdzudrtagsbzhimigcanmark": "\u0F36", "/tibt:caretdzudrtagsmelongcanmark": "\u0F13", "/tibt:caretyigmgophurshadmamark": "\u0F06", "/tibt:casubjoined": "\u0F95", "/tibt:cha": "\u0F46", "/tibt:chadrtagslogotypesign": "\u0F15", "/tibt:chasubjoined": "\u0F96", "/tibt:chemgomark": "\u0F38", "/tibt:da": "\u0F51", "/tibt:dasubjoined": "\u0FA1", "/tibt:dda": "\u0F4C", "/tibt:ddasubjoined": "\u0F9C", "/tibt:ddha": "\u0F4D", "/tibt:ddhasubjoined": "\u0F9D", "/tibt:delimitertshegbstarmark": "\u0F0C", "/tibt:dha": "\u0F52", "/tibt:dhasubjoined": "\u0FA2", "/tibt:drilbusymbol": "\u0FC4", "/tibt:dza": "\u0F5B", "/tibt:dzasubjoined": "\u0FAB", "/tibt:dzha": "\u0F5C", "/tibt:dzhasubjoined": "\u0FAC", "/tibt:eevowelsign": "\u0F7B", "/tibt:eight": "\u0F28", "/tibt:evowelsign": "\u0F7A", "/tibt:five": "\u0F25", "/tibt:four": "\u0F24", "/tibt:ga": "\u0F42", "/tibt:gasubjoined": "\u0F92", "/tibt:gha": "\u0F43", "/tibt:ghasubjoined": "\u0F93", "/tibt:grucanrgyingssign": "\u0F8A", "/tibt:grumedrgyingssign": "\u0F8B", "/tibt:gtertshegmark": "\u0F14", "/tibt:gteryigmgotruncatedamark": "\u0F01", "/tibt:gteryigmgoumgtertshegmamark": "\u0F03", "/tibt:gteryigmgoumrnambcadmamark": "\u0F02", "/tibt:gugrtagsgyasmark": "\u0F3B", "/tibt:gugrtagsgyonmark": "\u0F3A", "/tibt:ha": "\u0F67", "/tibt:halantamark": "\u0F84", "/tibt:halfeight": "\u0F31", "/tibt:halffive": "\u0F2E", "/tibt:halffour": "\u0F2D", "/tibt:halfnine": "\u0F32", "/tibt:halfone": "\u0F2A", "/tibt:halfseven": "\u0F30", "/tibt:halfsix": "\u0F2F", "/tibt:halfthree": "\u0F2C", "/tibt:halftwo": "\u0F2B", "/tibt:halfzero": "\u0F33", "/tibt:hasubjoined": "\u0FB7", "/tibt:heavybeatcantillationsign": "\u0FC0", "/tibt:iivowelsign": "\u0F73", "/tibt:intersyllabictshegmark": "\u0F0B", "/tibt:invertedmchucansign": "\u0F8C", "/tibt:invertedmchucansubjoinedsign": "\u0F8F", "/tibt:ivowelsign": "\u0F72", "/tibt:ja": "\u0F47", "/tibt:jasubjoined": "\u0F97", "/tibt:ka": "\u0F40", "/tibt:kasubjoined": "\u0F90", "/tibt:kha": "\u0F41", "/tibt:khasubjoined": "\u0F91", "/tibt:kka": "\u0F6B", "/tibt:kssa": "\u0F69", "/tibt:kssasubjoined": "\u0FB9", "/tibt:kurukha": "\u0FBE", "/tibt:kurukhabzhimigcan": "\u0FBF", "/tibt:la": "\u0F63", "/tibt:lasubjoined": "\u0FB3", "/tibt:lcetsacansign": "\u0F88", "/tibt:lcetsacansubjoinedsign": "\u0F8D", "/tibt:lcirtagssign": "\u0F86", "/tibt:leadingmchanrtagsmark": "\u0FD9", "/tibt:lhagrtagslogotypesign": "\u0F16", "/tibt:lightbeatcantillationsign": "\u0FC1", "/tibt:llvocalicvowelsign": "\u0F79", "/tibt:lvocalicvowelsign": "\u0F78", "/tibt:ma": "\u0F58", "/tibt:martshessign": "\u0F3F", "/tibt:masubjoined": "\u0FA8", "/tibt:mchucansign": "\u0F89", "/tibt:mchucansubjoinedsign": "\u0F8E", "/tibt:mnyamyiggimgorgyanmark": "\u0FD1", "/tibt:na": "\u0F53", "/tibt:nasubjoined": "\u0FA3", "/tibt:nga": "\u0F44", "/tibt:ngasbzungnyizlamark": "\u0F35", "/tibt:ngasbzungsgorrtagsmark": "\u0F37", "/tibt:ngasubjoined": "\u0F94", "/tibt:nine": "\u0F29", "/tibt:nna": "\u0F4E", "/tibt:nnasubjoined": "\u0F9E", "/tibt:norbubzhikhyilsymbol": "\u0FCC", "/tibt:norbugsumkhyilsymbol": "\u0FCB", "/tibt:norbunyiskhyilsymbol": "\u0FCA", "/tibt:norbusymbol": "\u0FC9", "/tibt:nya": "\u0F49", "/tibt:nyasubjoined": "\u0F99", "/tibt:nyisshadmark": "\u0F0E", "/tibt:nyistshegmark": "\u0FD2", "/tibt:nyistshegshadmark": "\u0F10", "/tibt:nyizlanaadasign": "\u0F82", "/tibt:omsyllable": "\u0F00", "/tibt:one": "\u0F21", "/tibt:oovowelsign": "\u0F7D", "/tibt:ovowelsign": "\u0F7C", "/tibt:pa": "\u0F54", "/tibt:padmagdansymbol": "\u0FC6", "/tibt:palutamark": "\u0F85", "/tibt:pasubjoined": "\u0FA4", "/tibt:pha": "\u0F55", "/tibt:phasubjoined": "\u0FA5", "/tibt:phurpasymbol": "\u0FC8", "/tibt:ra": "\u0F62", "/tibt:rafixed": "\u0F6A", "/tibt:rasubjoined": "\u0FB2", "/tibt:rasubjoinedfixed": "\u0FBC", "/tibt:rdeldkargcigsign": "\u0F1A", "/tibt:rdeldkargnyissign": "\u0F1B", "/tibt:rdeldkargsumsign": "\u0F1C", "/tibt:rdeldkarrdelnagsign": "\u0F1F", "/tibt:rdelnaggcigsign": "\u0F1D", "/tibt:rdelnaggnyissign": "\u0F1E", "/tibt:rdelnaggsumsign": "\u0FCF", "/tibt:rdelnagrdeldkarsign": "\u0FCE", "/tibt:rdorjergyagramsymbol": "\u0FC7", "/tibt:rdorjesymbol": "\u0FC5", "/tibt:reversediivowelsign": "\u0F81", "/tibt:reversedivowelsign": "\u0F80", "/tibt:rgyagramshadmark": "\u0F12", "/tibt:rinchenspungsshadmark": "\u0F11", "/tibt:rjessungarosign": "\u0F7E", "/tibt:rnambcadsign": "\u0F7F", "/tibt:rra": "\u0F6C", "/tibt:rrvocalicvowelsign": "\u0F77", "/tibt:rvocalicvowelsign": "\u0F76", "/tibt:sa": "\u0F66", "/tibt:sasubjoined": "\u0FB6", "/tibt:sbrulshadmark": "\u0F08", "/tibt:sbubchalcantillationsign": "\u0FC3", "/tibt:seven": "\u0F27", "/tibt:sha": "\u0F64", "/tibt:shadmark": "\u0F0D", "/tibt:shasubjoined": "\u0FB4", "/tibt:six": "\u0F26", "/tibt:snaldansign": "\u0F83", "/tibt:ssa": "\u0F65", "/tibt:ssasubjoined": "\u0FB5", "/tibt:subjoinedAA": "\u0FB0", "/tibt:svastileft": "\u0FD6", "/tibt:svastileftdot": "\u0FD8", "/tibt:svastiright": "\u0FD5", "/tibt:svastirightdot": "\u0FD7", "/tibt:ta": "\u0F4F", "/tibt:tasubjoined": "\u0F9F", "/tibt:tha": "\u0F50", "/tibt:thasubjoined": "\u0FA0", "/tibt:three": "\u0F23", "/tibt:trailingmchanrtagsmark": "\u0FDA", "/tibt:tsa": "\u0F59", "/tibt:tsaphrumark": "\u0F39", "/tibt:tsasubjoined": "\u0FA9", "/tibt:tsha": "\u0F5A", "/tibt:tshasubjoined": "\u0FAA", "/tibt:tshegshadmark": "\u0F0F", "/tibt:tta": "\u0F4A", "/tibt:ttasubjoined": "\u0F9A", "/tibt:ttha": "\u0F4B", "/tibt:tthasubjoined": "\u0F9B", "/tibt:two": "\u0F22", "/tibt:uuvowelsign": "\u0F75", "/tibt:uvowelsign": "\u0F74", "/tibt:wa": "\u0F5D", "/tibt:wasubjoined": "\u0FAD", "/tibt:wasubjoinedfixed": "\u0FBA", "/tibt:ya": "\u0F61", "/tibt:yangrtagssign": "\u0F87", "/tibt:yartshessign": "\u0F3E", "/tibt:yasubjoined": "\u0FB1", "/tibt:yasubjoinedfixed": "\u0FBB", "/tibt:yigmgomdunmainitialmark": "\u0F04", "/tibt:yigmgosgabmaclosingmark": "\u0F05", "/tibt:yigmgotshegshadmamark": "\u0F07", "/tibt:za": "\u0F5F", "/tibt:zasubjoined": "\u0FAF", "/tibt:zero": "\u0F20", "/tibt:zha": "\u0F5E", "/tibt:zhasubjoined": "\u0FAE", "/ticirclekatakana": "\u32E0", "/tickconvavediamondleftwhite": "\u27E2", "/tickconvavediamondrightwhite": "\u27E3", "/ticket": "\u1F3AB", "/tickleftwhitesquare": "\u27E4", "/tickrightwhitesquare": "\u27E5", "/tifcha:hb": "\u0596", "/tiger": "\u1F405", "/tigerFace": "\u1F42F", "/tihiragana": "\u3061", "/tikatakana": "\u30C1", "/tikatakanahalfwidth": "\uFF81", "/tikeutacirclekorean": "\u3270", "/tikeutaparenkorean": "\u3210", "/tikeutcirclekorean": "\u3262", "/tikeutkorean": "\u3137", "/tikeutparenkorean": "\u3202", "/tilde": "\u02DC", "/tildebelowcmb": "\u0330", "/tildecmb": "\u0303", "/tildecomb": "\u0303", "/tildediaeresisfunc": "\u2368", "/tildedotaccent": "\u2E1E", "/tildedotbelow": "\u2E1F", "/tildedoublecmb": "\u0360", "/tildeequalsreversed": "\u22CD", "/tildelowmod": "\u02F7", "/tildeoperator": "\u223C", "/tildeoverlaycmb": "\u0334", "/tildereversed": "\u223D", "/tildering": "\u2E1B", "/tildetpl": "\u224B", "/tildeverticalcmb": "\u033E", "/timerclock": "\u23F2", "/timescircle": "\u2297", "/tinsular": "\uA787", "/tipehahebrew": "\u0596", "/tipehalefthebrew": "\u0596", "/tippigurmukhi": "\u0A70", "/tiredFace": "\u1F62B", "/tironiansignet": "\u204A", "/tirtatumetespada": "\uA9DE", "/titlocmbcyr": "\u0483", "/titlocyrilliccmb": "\u0483", "/tiwnarmenian": "\u057F", "/tjekomicyr": "\u050F", "/tlinebelow": "\u1E6F", "/tmonospace": "\uFF54", "/toarmenian": "\u0569", "/tocirclekatakana": "\u32E3", "/tocornerarrowNW": "\u21F1", "/tocornerarrowSE": "\u21F2", "/tohiragana": "\u3068", "/toilet": "\u1F6BD", "/tokatakana": "\u30C8", "/tokatakanahalfwidth": "\uFF84", "/tokyoTower": "\u1F5FC", "/tolongvowel": "\uA9B5", "/tomato": "\u1F345", "/tonebarextrahighmod": "\u02E5", "/tonebarextralowmod": "\u02E9", "/tonebarhighmod": "\u02E6", "/tonebarlowmod": "\u02E8", "/tonebarmidmod": "\u02E7", "/tonefive": "\u01BD", "/tonehighbeginmod": "\u02F9", "/tonehighendmod": "\u02FA", "/tonelowbeginmod": "\u02FB", "/tonelowendmod": "\u02FC", "/tonesix": "\u0185", "/tonetwo": "\u01A8", "/tongue": "\u1F445", "/tonos": "\u0384", "/tonsquare": "\u3327", "/topHat": "\u1F3A9", "/topUpwardsArrowAbove": "\u1F51D", "/topatakthai": "\u0E0F", "/tortoiseshellbracketleft": "\u3014", "/tortoiseshellbracketleftsmall": "\uFE5D", "/tortoiseshellbracketleftvertical": "\uFE39", "/tortoiseshellbracketright": "\u3015", "/tortoiseshellbracketrightsmall": "\uFE5E", "/tortoiseshellbracketrightvertical": "\uFE3A", "/totalrunout": "\u2330", "/totaothai": "\u0E15", "/tpalatalhook": "\u01AB", "/tparen": "\u24AF", "/tparenthesized": "\u24AF", "/trackball": "\u1F5B2", "/tractor": "\u1F69C", "/trademark": "\u2122", "/trademarksans": "\uF8EA", "/trademarkserif": "\uF6DB", "/train": "\u1F686", "/tram": "\u1F68A", "/tramCar": "\u1F68B", "/trapeziumwhite": "\u23E2", "/tresillo": "\uA72B", "/tretroflex": "\u0288", "/tretroflexhook": "\u0288", "/triagdn": "\u25BC", "/triaglf": "\u25C4", "/triagrt": "\u25BA", "/triagup": "\u25B2", "/triangleWithRoundedCorners": "\u1F6C6", "/triangledotupwhite": "\u25EC", "/triangledownblack": "\u25BC", "/triangledownsmallblack": "\u25BE", "/triangledownsmallwhite": "\u25BF", "/triangledownwhite": "\u25BD", "/trianglehalfupleftblack": "\u25ED", "/trianglehalfuprightblack": "\u25EE", "/triangleleftblack": "\u25C0", "/triangleleftsmallblack": "\u25C2", "/triangleleftsmallwhite": "\u25C3", "/triangleleftwhite": "\u25C1", "/triangleright": "\u22BF", "/trianglerightblack": "\u25B6", "/trianglerightsmallblack": "\u25B8", "/trianglerightsmallwhite": "\u25B9", "/trianglerightwhite": "\u25B7", "/triangleupblack": "\u25B2", "/triangleupsmallblack": "\u25B4", "/triangleupsmallwhite": "\u25B5", "/triangleupwhite": "\u25B3", "/triangularFlagOnPost": "\u1F6A9", "/triangularRuler": "\u1F4D0", "/triangularbullet": "\u2023", "/tricolon": "\u205D", "/tricontainingtriwhiteanglesmall": "\u27C1", "/tridentEmblem": "\u1F531", "/trigramearth": "\u2637", "/trigramfire": "\u2632", "/trigramheaven": "\u2630", "/trigramlake": "\u2631", "/trigrammountain": "\u2636", "/trigramthunder": "\u2633", "/trigramwater": "\u2635", "/trigramwind": "\u2634", "/triplearrowleft": "\u21DA", "/triplearrowright": "\u21DB", "/tripledot": "\u061E", "/trisememetrical": "\u23D7", "/trns:baby": "\u1F6BC", "/trolleybus": "\u1F68E", "/trophy": "\u1F3C6", "/tropicalDrink": "\u1F379", "/tropicalFish": "\u1F420", "/truckblack": "\u26DF", "/true": "\u22A8", "/trumpet": "\u1F3BA", "/ts": "\u02A6", "/tsadi": "\u05E6", "/tsadi:hb": "\u05E6", "/tsadidagesh": "\uFB46", "/tsadidageshhebrew": "\uFB46", "/tsadihebrew": "\u05E6", "/tsadiwithdagesh:hb": "\uFB46", "/tsecyr": "\u0446", "/tsecyrillic": "\u0446", "/tsere": "\u05B5", "/tsere12": "\u05B5", "/tsere1e": "\u05B5", "/tsere2b": "\u05B5", "/tsere:hb": "\u05B5", "/tserehebrew": "\u05B5", "/tserenarrowhebrew": "\u05B5", "/tserequarterhebrew": "\u05B5", "/tserewidehebrew": "\u05B5", "/tshecyr": "\u045B", "/tshecyrillic": "\u045B", "/tsinnorit:hb": "\u05AE", "/tstroke": "\u2C66", "/tsuperior": "\uF6F3", "/ttabengali": "\u099F", "/ttadeva": "\u091F", "/ttagujarati": "\u0A9F", "/ttagurmukhi": "\u0A1F", "/ttamahaprana": "\uA99C", "/tteh": "\u0679", "/tteh.fina": "\uFB67", "/tteh.init": "\uFB68", "/tteh.isol": "\uFB66", "/tteh.medi": "\uFB69", "/tteharabic": "\u0679", "/tteheh": "\u067A", "/tteheh.fina": "\uFB5F", "/tteheh.init": "\uFB60", "/tteheh.isol": "\uFB5E", "/tteheh.medi": "\uFB61", "/ttehfinalarabic": "\uFB67", "/ttehinitialarabic": "\uFB68", "/ttehmedialarabic": "\uFB69", "/tthabengali": "\u09A0", "/tthadeva": "\u0920", "/tthagujarati": "\u0AA0", "/tthagurmukhi": "\u0A20", "/tturned": "\u0287", "/tucirclekatakana": "\u32E1", "/tugrik": "\u20AE", "/tuhiragana": "\u3064", "/tukatakana": "\u30C4", "/tukatakanahalfwidth": "\uFF82", "/tulip": "\u1F337", "/tum": "\uA777", "/turkishlira": "\u20BA", "/turnedOkHandSign": "\u1F58F", "/turnedcomma": "\u2E32", "/turneddagger": "\u2E38", "/turneddigitthree": "\u218B", "/turneddigittwo": "\u218A", "/turnedpiselehpada": "\uA9CD", "/turnedsemicolon": "\u2E35", "/turnedshogipieceblack": "\u26CA", "/turnedshogipiecewhite": "\u26C9", "/turnstiledblverticalbarright": "\u22AB", "/turnstileleftrightdbl": "\u27DA", "/turnstiletplverticalbarright": "\u22AA", "/turtle": "\u1F422", "/tusmallhiragana": "\u3063", "/tusmallkatakana": "\u30C3", "/tusmallkatakanahalfwidth": "\uFF6F", "/twelve.roman": "\u216B", "/twelve.romansmall": "\u217B", "/twelvecircle": "\u246B", "/twelvecircleblack": "\u24EC", "/twelveparen": "\u247F", "/twelveparenthesized": "\u247F", "/twelveperiod": "\u2493", "/twelveroman": "\u217B", "/twenty-twopointtwosquare": "\u1F1A2", "/twentycircle": "\u2473", "/twentycircleblack": "\u24F4", "/twentycirclesquare": "\u3249", "/twentyeightcircle": "\u3258", "/twentyfivecircle": "\u3255", "/twentyfourcircle": "\u3254", "/twentyhangzhou": "\u5344", "/twentyninecircle": "\u3259", "/twentyonecircle": "\u3251", "/twentyparen": "\u2487", "/twentyparenthesized": "\u2487", "/twentyperiod": "\u249B", "/twentysevencircle": "\u3257", "/twentysixcircle": "\u3256", "/twentythreecircle": "\u3253", "/twentytwocircle": "\u3252", "/twistedRightwardsArrows": "\u1F500", "/two": "\u0032", "/two.inferior": "\u2082", "/two.roman": "\u2161", "/two.romansmall": "\u2171", "/twoButtonMouse": "\u1F5B0", "/twoHearts": "\u1F495", "/twoMenHoldingHands": "\u1F46C", "/twoSpeechBubbles": "\u1F5EA", "/twoWomenHoldingHands": "\u1F46D", "/twoarabic": "\u0662", "/twoasterisksalignedvertically": "\u2051", "/twobengali": "\u09E8", "/twocircle": "\u2461", "/twocircledbl": "\u24F6", "/twocircleinversesansserif": "\u278B", "/twocomma": "\u1F103", "/twodeva": "\u0968", "/twodotenleader": "\u2025", "/twodotleader": "\u2025", "/twodotleadervertical": "\uFE30", "/twodotpunctuation": "\u205A", "/twodotsoveronedot": "\u2E2A", "/twofar": "\u06F2", "/twofifths": "\u2156", "/twogujarati": "\u0AE8", "/twogurmukhi": "\u0A68", "/twohackarabic": "\u0662", "/twohangzhou": "\u3022", "/twoideographiccircled": "\u3281", "/twoideographicparen": "\u3221", "/twoinferior": "\u2082", "/twoksquare": "\u1F19D", "/twomonospace": "\uFF12", "/twonumeratorbengali": "\u09F5", "/twooldstyle": "\uF732", "/twoparen": "\u2475", "/twoparenthesized": "\u2475", "/twoperiod": "\u2489", "/twopersian": "\u06F2", "/tworoman": "\u2171", "/twoshortsjoinedmetrical": "\u23D6", "/twoshortsoverlongmetrical": "\u23D5", "/twostroke": "\u01BB", "/twosuperior": "\u00B2", "/twothai": "\u0E52", "/twothirds": "\u2154", "/twowayleftwaytrafficblack": "\u26D6", "/twowayleftwaytrafficwhite": "\u26D7", "/tz": "\uA729", "/u": "\u0075", "/u.fina": "\uFBD8", "/u.isol": "\uFBD7", "/uacute": "\u00FA", "/uacutedblcyr": "\u04F3", "/ubar": "\u0289", "/ubengali": "\u0989", "/ubopomofo": "\u3128", "/ubracketleft": "\u2E26", "/ubracketright": "\u2E27", "/ubreve": "\u016D", "/ucaron": "\u01D4", "/ucircle": "\u24E4", "/ucirclekatakana": "\u32D2", "/ucircumflex": "\u00FB", "/ucircumflexbelow": "\u1E77", "/ucyr": "\u0443", "/ucyrillic": "\u0443", "/udattadeva": "\u0951", "/udblacute": "\u0171", "/udblgrave": "\u0215", "/udeva": "\u0909", "/udieresis": "\u00FC", "/udieresisacute": "\u01D8", "/udieresisbelow": "\u1E73", "/udieresiscaron": "\u01DA", "/udieresiscyr": "\u04F1", "/udieresiscyrillic": "\u04F1", "/udieresisgrave": "\u01DC", "/udieresismacron": "\u01D6", "/udotbelow": "\u1EE5", "/ugrave": "\u00F9", "/ugravedbl": "\u0215", "/ugujarati": "\u0A89", "/ugurmukhi": "\u0A09", "/uhamza": "\u0677", "/uhamza.isol": "\uFBDD", "/uhdsquare": "\u1F1AB", "/uhiragana": "\u3046", "/uhoi": "\u1EE7", "/uhookabove": "\u1EE7", "/uhorn": "\u01B0", "/uhornacute": "\u1EE9", "/uhorndotbelow": "\u1EF1", "/uhorngrave": "\u1EEB", "/uhornhoi": "\u1EED", "/uhornhookabove": "\u1EED", "/uhorntilde": "\u1EEF", "/uhungarumlaut": "\u0171", "/uhungarumlautcyrillic": "\u04F3", "/uighurkazakhkirghizalefmaksura.init": "\uFBE8", "/uighurkazakhkirghizalefmaksura.medi": "\uFBE9", "/uighurkirghizyeh.init_hamzaabove.medi_alefmaksura.fina": "\uFBF9", "/uighurkirghizyeh.init_hamzaabove.medi_alefmaksura.medi": "\uFBFB", "/uighurkirghizyeh.medi_hamzaabove.medi_alefmaksura.fina": "\uFBFA", "/uinvertedbreve": "\u0217", "/ukatakana": "\u30A6", "/ukatakanahalfwidth": "\uFF73", "/ukcyr": "\u0479", "/ukcyrillic": "\u0479", "/ukorean": "\u315C", "/um": "\uA778", "/umacron": "\u016B", "/umacroncyr": "\u04EF", "/umacroncyrillic": "\u04EF", "/umacrondieresis": "\u1E7B", "/umatragurmukhi": "\u0A41", "/umbrella": "\u2602", "/umbrellaonground": "\u26F1", "/umbrellaraindrops": "\u2614", "/umonospace": "\uFF55", "/unamusedFace": "\u1F612", "/unaspiratedmod": "\u02ED", "/underscore": "\u005F", "/underscorecenterline": "\uFE4E", "/underscoredashed": "\uFE4D", "/underscoredbl": "\u2017", "/underscoremonospace": "\uFF3F", "/underscorevertical": "\uFE33", "/underscorewavy": "\uFE4F", "/underscorewavyvertical": "\uFE34", "/undertie": "\u203F", "/undo": "\u238C", "/union": "\u222A", "/unionarray": "\u22C3", "/uniondbl": "\u22D3", "/universal": "\u2200", "/unmarriedpartnership": "\u26AF", "/uogonek": "\u0173", "/uonsquare": "\u3306", "/upPointingAirplane": "\u1F6E7", "/upPointingMilitaryAirplane": "\u1F6E6", "/upPointingSmallAirplane": "\u1F6E8", "/uparen": "\u24B0", "/uparenthesized": "\u24B0", "/uparrowleftofdownarrow": "\u21C5", "/upblock": "\u2580", "/updblhorzsng": "\u2568", "/updblleftsng": "\u255C", "/updblrightsng": "\u2559", "/upheavydnhorzlight": "\u2540", "/upheavyhorzlight": "\u2538", "/upheavyleftdnlight": "\u2526", "/upheavyleftlight": "\u251A", "/upheavyrightdnlight": "\u251E", "/upheavyrightlight": "\u2516", "/uplightdnhorzheavy": "\u2548", "/uplighthorzheavy": "\u2537", "/uplightleftdnheavy": "\u252A", "/uplightleftheavy": "\u2519", "/uplightrightdnheavy": "\u2522", "/uplightrightheavy": "\u2515", "/upperHalfBlock": "\u2580", "/upperOneEighthBlock": "\u2594", "/upperRightShadowedWhiteCircle": "\u1F53F", "/upperdothebrew": "\u05C4", "/upperhalfcircle": "\u25E0", "/upperhalfcircleinversewhite": "\u25DA", "/upperquadrantcirculararcleft": "\u25DC", "/upperquadrantcirculararcright": "\u25DD", "/uppertriangleleft": "\u25F8", "/uppertriangleleftblack": "\u25E4", "/uppertriangleright": "\u25F9", "/uppertrianglerightblack": "\u25E5", "/upsideDownFace": "\u1F643", "/upsilon": "\u03C5", "/upsilonacute": "\u1F7B", "/upsilonasper": "\u1F51", "/upsilonasperacute": "\u1F55", "/upsilonaspergrave": "\u1F53", "/upsilonaspertilde": "\u1F57", "/upsilonbreve": "\u1FE0", "/upsilondieresis": "\u03CB", "/upsilondieresisacute": "\u1FE3", "/upsilondieresisgrave": "\u1FE2", "/upsilondieresistilde": "\u1FE7", "/upsilondieresistonos": "\u03B0", "/upsilongrave": "\u1F7A", "/upsilonlatin": "\u028A", "/upsilonlenis": "\u1F50", "/upsilonlenisacute": "\u1F54", "/upsilonlenisgrave": "\u1F52", "/upsilonlenistilde": "\u1F56", "/upsilontilde": "\u1FE6", "/upsilontonos": "\u03CD", "/upsilonwithmacron": "\u1FE1", "/upsnghorzdbl": "\u2567", "/upsngleftdbl": "\u255B", "/upsngrightdbl": "\u2558", "/uptackbelowcmb": "\u031D", "/uptackmod": "\u02D4", "/upwithexclamationmarksquare": "\u1F199", "/uragurmukhi": "\u0A73", "/uranus": "\u2645", "/uring": "\u016F", "/ushortcyr": "\u045E", "/ushortcyrillic": "\u045E", "/usmallhiragana": "\u3045", "/usmallkatakana": "\u30A5", "/usmallkatakanahalfwidth": "\uFF69", "/usmod": "\uA770", "/ustraightcyr": "\u04AF", "/ustraightcyrillic": "\u04AF", "/ustraightstrokecyr": "\u04B1", "/ustraightstrokecyrillic": "\u04B1", "/utilde": "\u0169", "/utildeacute": "\u1E79", "/utildebelow": "\u1E75", "/uubengali": "\u098A", "/uudeva": "\u090A", "/uugujarati": "\u0A8A", "/uugurmukhi": "\u0A0A", "/uumatragurmukhi": "\u0A42", "/uuvowelsignbengali": "\u09C2", "/uuvowelsigndeva": "\u0942", "/uuvowelsigngujarati": "\u0AC2", "/uvowelsignbengali": "\u09C1", "/uvowelsigndeva": "\u0941", "/uvowelsigngujarati": "\u0AC1", "/v": "\u0076", "/vadeva": "\u0935", "/vagujarati": "\u0AB5", "/vagurmukhi": "\u0A35", "/vakatakana": "\u30F7", "/vanedownfunc": "\u2356", "/vaneleftfunc": "\u2345", "/vanerightfunc": "\u2346", "/vaneupfunc": "\u234F", "/varikajudeospanish:hb": "\uFB1E", "/vav": "\u05D5", "/vav:hb": "\u05D5", "/vav_vav:hb": "\u05F0", "/vav_yod:hb": "\u05F1", "/vavdagesh": "\uFB35", "/vavdagesh65": "\uFB35", "/vavdageshhebrew": "\uFB35", "/vavhebrew": "\u05D5", "/vavholam": "\uFB4B", "/vavholamhebrew": "\uFB4B", "/vavvavhebrew": "\u05F0", "/vavwithdagesh:hb": "\uFB35", "/vavwithholam:hb": "\uFB4B", "/vavyodhebrew": "\u05F1", "/vcircle": "\u24E5", "/vcurl": "\u2C74", "/vdiagonalstroke": "\uA75F", "/vdotbelow": "\u1E7F", "/ve.fina": "\uFBDF", "/ve.isol": "\uFBDE", "/ve:abovetonecandra": "\u1CF4", "/ve:anusvaraantargomukhasign": "\u1CE9", "/ve:anusvarabahirgomukhasign": "\u1CEA", "/ve:anusvarasignlong": "\u1CEF", "/ve:anusvaraubhayatomukhasign": "\u1CF1", "/ve:anusvaravamagomukhasign": "\u1CEB", "/ve:anusvaravamagomukhawithtailsign": "\u1CEC", "/ve:ardhavisargasign": "\u1CF2", "/ve:atharvaindependentsvaritatone": "\u1CE1", "/ve:atikramasign": "\u1CF7", "/ve:belowtonecandra": "\u1CD8", "/ve:dotbelowtone": "\u1CDD", "/ve:hexiformanusvarasignlong": "\u1CEE", "/ve:jihvamuliyasign": "\u1CF5", "/ve:karshanatone": "\u1CD0", "/ve:kathakaanudattatone": "\u1CDC", "/ve:nihshvasasign": "\u1CD3", "/ve:prenkhatone": "\u1CD2", "/ve:rigkashmiriindependentsvaritatone": "\u1CE0", "/ve:ringabovetone": "\u1CF8", "/ve:ringabovetonedbl": "\u1CF9", "/ve:rotatedardhavisargasign": "\u1CF3", "/ve:rthanganusvarasignlong": "\u1CF0", "/ve:sharatone": "\u1CD1", "/ve:svaritatonedbl": "\u1CDA", "/ve:svaritatonetpl": "\u1CDB", "/ve:threedotsbelowtone": "\u1CDF", "/ve:tiryaksign": "\u1CED", "/ve:twodotsbelowtone": "\u1CDE", "/ve:upadhmaniyasign": "\u1CF6", "/ve:visargaanudattasign": "\u1CE5", "/ve:visargaanudattasignreversed": "\u1CE6", "/ve:visargaanudattawithtailsign": "\u1CE8", "/ve:visargasvaritasign": "\u1CE2", "/ve:visargaudattasign": "\u1CE3", "/ve:visargaudattasignreversed": "\u1CE4", "/ve:visargaudattawithtailsign": "\u1CE7", "/ve:yajuraggravatedindependentsvaritatone": "\u1CD5", "/ve:yajurindependentsvaritatone": "\u1CD6", "/ve:yajurkathakaindependentsvaritaschroedertone": "\u1CD9", "/ve:yajurkathakaindependentsvaritatone": "\u1CD7", "/ve:yajurmidlinesvaritasign": "\u1CD4", "/vecyr": "\u0432", "/vecyrillic": "\u0432", "/veh": "\u06A4", "/veh.fina": "\uFB6B", "/veh.init": "\uFB6C", "/veh.isol": "\uFB6A", "/veh.medi": "\uFB6D", "/veharabic": "\u06A4", "/vehfinalarabic": "\uFB6B", "/vehinitialarabic": "\uFB6C", "/vehmedialarabic": "\uFB6D", "/vekatakana": "\u30F9", "/vend": "\uA769", "/venus": "\u2640", "/versicle": "\u2123", "/vert:bracketwhiteleft": "\uFE17", "/vert:brakcetwhiteright": "\uFE18", "/vert:colon": "\uFE13", "/vert:comma": "\uFE10", "/vert:ellipsishor": "\uFE19", "/vert:exclam": "\uFE15", "/vert:ideographiccomma": "\uFE11", "/vert:ideographicfullstop": "\uFE12", "/vert:question": "\uFE16", "/vert:semicolon": "\uFE14", "/vertdblhorzsng": "\u256B", "/vertdblleftsng": "\u2562", "/vertdblrightsng": "\u255F", "/vertheavyhorzlight": "\u2542", "/vertheavyleftlight": "\u2528", "/vertheavyrightlight": "\u2520", "/verticalTrafficLight": "\u1F6A6", "/verticalbar": "\u007C", "/verticalbardbl": "\u2016", "/verticalbarhorizontalstroke": "\u27CA", "/verticalbarwhitearrowonpedestalup": "\u21ED", "/verticalfourdots": "\u205E", "/verticalideographiciterationmark": "\u303B", "/verticalkanarepeatmark": "\u3031", "/verticalkanarepeatmarklowerhalf": "\u3035", "/verticalkanarepeatmarkupperhalf": "\u3033", "/verticalkanarepeatwithvoicedsoundmark": "\u3032", "/verticalkanarepeatwithvoicedsoundmarkupperhalf": "\u3034", "/verticallineabovecmb": "\u030D", "/verticallinebelowcmb": "\u0329", "/verticallinelowmod": "\u02CC", "/verticallinemod": "\u02C8", "/verticalmalestroke": "\u26A8", "/verticalsdbltrokearrowleft": "\u21FA", "/verticalsdbltrokearrowleftright": "\u21FC", "/verticalsdbltrokearrowright": "\u21FB", "/verticalstrokearrowleft": "\u21F7", "/verticalstrokearrowleftright": "\u21F9", "/verticalstrokearrowright": "\u21F8", "/vertlighthorzheavy": "\u253F", "/vertlightleftheavy": "\u2525", "/vertlightrightheavy": "\u251D", "/vertsnghorzdbl": "\u256A", "/vertsngleftdbl": "\u2561", "/vertsngrightdbl": "\u255E", "/verymuchgreater": "\u22D9", "/verymuchless": "\u22D8", "/vesta": "\u26B6", "/vewarmenian": "\u057E", "/vhook": "\u028B", "/vibrationMode": "\u1F4F3", "/videoCamera": "\u1F4F9", "/videoGame": "\u1F3AE", "/videocassette": "\u1F4FC", "/viewdatasquare": "\u2317", "/vikatakana": "\u30F8", "/violin": "\u1F3BB", "/viramabengali": "\u09CD", "/viramadeva": "\u094D", "/viramagujarati": "\u0ACD", "/virgo": "\u264D", "/visargabengali": "\u0983", "/visargadeva": "\u0903", "/visargagujarati": "\u0A83", "/visigothicz": "\uA763", "/vmonospace": "\uFF56", "/voarmenian": "\u0578", "/vodsquare": "\u1F1AC", "/voicediterationhiragana": "\u309E", "/voicediterationkatakana": "\u30FE", "/voicedmarkkana": "\u309B", "/voicedmarkkanahalfwidth": "\uFF9E", "/voicingmod": "\u02EC", "/vokatakana": "\u30FA", "/volapukae": "\uA79B", "/volapukoe": "\uA79D", "/volapukue": "\uA79F", "/volcano": "\u1F30B", "/volleyball": "\u1F3D0", "/vovermfullwidth": "\u33DE", "/vowelVabove": "\u065A", "/voweldotbelow": "\u065C", "/vowelinvertedVabove": "\u065B", "/vparen": "\u24B1", "/vparenthesized": "\u24B1", "/vrighthook": "\u2C71", "/vssquare": "\u1F19A", "/vtilde": "\u1E7D", "/vturned": "\u028C", "/vuhiragana": "\u3094", "/vukatakana": "\u30F4", "/vwelsh": "\u1EFD", "/vy": "\uA761", "/w": "\u0077", "/wacirclekatakana": "\u32FB", "/wacute": "\u1E83", "/waekorean": "\u3159", "/wahiragana": "\u308F", "/wakatakana": "\u30EF", "/wakatakanahalfwidth": "\uFF9C", "/wakorean": "\u3158", "/waningCrescentMoon": "\u1F318", "/waningGibbousMoon": "\u1F316", "/warning": "\u26A0", "/wasmallhiragana": "\u308E", "/wasmallkatakana": "\u30EE", "/wastebasket": "\u1F5D1", "/watch": "\u231A", "/waterBuffalo": "\u1F403", "/waterCloset": "\u1F6BE", "/waterWave": "\u1F30A", "/waterideographiccircled": "\u328C", "/waterideographicparen": "\u322C", "/watermelon": "\u1F349", "/wattosquare": "\u3357", "/wavedash": "\u301C", "/wavingBlackFlag": "\u1F3F4", "/wavingHandSign": "\u1F44B", "/wavingWhiteFlag": "\u1F3F3", "/wavydash": "\u3030", "/wavyhamzabelow": "\u065F", "/wavyline": "\u2307", "/wavyunderscorevertical": "\uFE34", "/waw": "\u0648", "/waw.fina": "\uFEEE", "/waw.isol": "\uFEED", "/wawDigitThreeAbove": "\u0779", "/wawDigitTwoAbove": "\u0778", "/wawarabic": "\u0648", "/wawdotabove": "\u06CF", "/wawfinalarabic": "\uFEEE", "/wawhamza": "\u0624", "/wawhamza.fina": "\uFE86", "/wawhamza.isol": "\uFE85", "/wawhamzaabovearabic": "\u0624", "/wawhamzaabovefinalarabic": "\uFE86", "/wawhighhamza": "\u0676", "/wawring": "\u06C4", "/wawsmall": "\u06E5", "/wawtwodotsabove": "\u06CA", "/waxingCrescentMoon": "\u1F312", "/waxingGibbousMoon": "\u1F314", "/wbfullwidth": "\u33DD", "/wbsquare": "\u33DD", "/wcircle": "\u24E6", "/wcircumflex": "\u0175", "/wcsquare": "\u1F14F", "/wcsquareblack": "\u1F18F", "/wdieresis": "\u1E85", "/wdot": "\u1E87", "/wdotaccent": "\u1E87", "/wdotbelow": "\u1E89", "/wearyCatFace": "\u1F640", "/wearyFace": "\u1F629", "/wecirclekatakana": "\u32FD", "/wecyr": "\u051D", "/wedding": "\u1F492", "/wehiragana": "\u3091", "/weierstrass": "\u2118", "/weightLifter": "\u1F3CB", "/wekatakana": "\u30F1", "/wekorean": "\u315E", "/weokorean": "\u315D", "/westsyriaccross": "\u2670", "/wgrave": "\u1E81", "/whale": "\u1F40B", "/wheelchair": "\u267F", "/wheelofdharma": "\u2638", "/whiteDownPointingBackhandIndex": "\u1F447", "/whiteDownPointingLeftHandIndex": "\u1F597", "/whiteFlower": "\u1F4AE", "/whiteHardShellFloppyDisk": "\u1F5AB", "/whiteLatinCross": "\u1F546", "/whiteLeftPointingBackhandIndex": "\u1F448", "/whitePennant": "\u1F3F1", "/whiteRightPointingBackhandIndex": "\u1F449", "/whiteSquareButton": "\u1F533", "/whiteSun": "\u1F323", "/whiteSunBehindCloud": "\u1F325", "/whiteSunBehindCloudRain": "\u1F326", "/whiteSunSmallCloud": "\u1F324", "/whiteTouchtoneTelephone": "\u1F57E", "/whiteUpPointingBackhandIndex": "\u1F446", "/whitearrowdown": "\u21E9", "/whitearrowfromwallright": "\u21F0", "/whitearrowleft": "\u21E6", "/whitearrowonpedestalup": "\u21EB", "/whitearrowright": "\u21E8", "/whitearrowup": "\u21E7", "/whitearrowupdown": "\u21F3", "/whitearrowupfrombar": "\u21EA", "/whitebullet": "\u25E6", "/whitecircle": "\u25CB", "/whitecircleinverse": "\u25D9", "/whitecornerbracketleft": "\u300E", "/whitecornerbracketleftvertical": "\uFE43", "/whitecornerbracketright": "\u300F", "/whitecornerbracketrightvertical": "\uFE44", "/whitedblarrowonpedestalup": "\u21EF", "/whitedblarrowup": "\u21EE", "/whitediamond": "\u25C7", "/whitediamondcontainingblacksmalldiamond": "\u25C8", "/whitedownpointingsmalltriangle": "\u25BF", "/whitedownpointingtriangle": "\u25BD", "/whiteleftpointingsmalltriangle": "\u25C3", "/whiteleftpointingtriangle": "\u25C1", "/whitelenticularbracketleft": "\u3016", "/whitelenticularbracketright": "\u3017", "/whiterightpointingsmalltriangle": "\u25B9", "/whiterightpointingtriangle": "\u25B7", "/whitesesamedot": "\uFE46", "/whitesmallsquare": "\u25AB", "/whitesmilingface": "\u263A", "/whitesquare": "\u25A1", "/whitesquarebracketleft": "\u301A", "/whitesquarebracketright": "\u301B", "/whitestar": "\u2606", "/whitetelephone": "\u260F", "/whitetortoiseshellbracketleft": "\u3018", "/whitetortoiseshellbracketright": "\u3019", "/whiteuppointingsmalltriangle": "\u25B5", "/whiteuppointingtriangle": "\u25B3", "/whook": "\u2C73", "/wicirclekatakana": "\u32FC", "/wigglylinevertical": "\u2E3E", "/wignyan": "\uA983", "/wihiragana": "\u3090", "/wikatakana": "\u30F0", "/wikorean": "\u315F", "/windBlowingFace": "\u1F32C", "/windChime": "\u1F390", "/windupada": "\uA9C6", "/wineGlass": "\u1F377", "/winkingFace": "\u1F609", "/wiredKeyboard": "\u1F5AE", "/wmonospace": "\uFF57", "/wocirclekatakana": "\u32FE", "/wohiragana": "\u3092", "/wokatakana": "\u30F2", "/wokatakanahalfwidth": "\uFF66", "/wolfFace": "\u1F43A", "/woman": "\u1F469", "/womanBunnyEars": "\u1F46F", "/womansBoots": "\u1F462", "/womansClothes": "\u1F45A", "/womansHat": "\u1F452", "/womansSandal": "\u1F461", "/womens": "\u1F6BA", "/won": "\u20A9", "/wonmonospace": "\uFFE6", "/woodideographiccircled": "\u328D", "/woodideographicparen": "\u322D", "/wordjoiner": "\u2060", "/wordseparatormiddledot": "\u2E31", "/worldMap": "\u1F5FA", "/worriedFace": "\u1F61F", "/wowaenthai": "\u0E27", "/wparen": "\u24B2", "/wparenthesized": "\u24B2", "/wrappedPresent": "\u1F381", "/wreathproduct": "\u2240", "/wrench": "\u1F527", "/wring": "\u1E98", "/wsuperior": "\u02B7", "/wsupmod": "\u02B7", "/wturned": "\u028D", "/wulumelikvowel": "\uA9B7", "/wuluvowel": "\uA9B6", "/wynn": "\u01BF", "/x": "\u0078", "/x.inferior": "\u2093", "/xabovecmb": "\u033D", "/xatailcyr": "\u04B3", "/xbopomofo": "\u3112", "/xcircle": "\u24E7", "/xdieresis": "\u1E8D", "/xdot": "\u1E8B", "/xdotaccent": "\u1E8B", "/xeharmenian": "\u056D", "/xi": "\u03BE", "/xmonospace": "\uFF58", "/xor": "\u22BB", "/xparen": "\u24B3", "/xparenthesized": "\u24B3", "/xsuperior": "\u02E3", "/xsupmod": "\u02E3", "/y": "\u0079", "/yaadosquare": "\u334E", "/yaarusquare": "\u334F", "/yabengali": "\u09AF", "/yacirclekatakana": "\u32F3", "/yacute": "\u00FD", "/yacyr": "\u044F", "/yadeva": "\u092F", "/yaecyr": "\u0519", "/yaekorean": "\u3152", "/yagujarati": "\u0AAF", "/yagurmukhi": "\u0A2F", "/yahiragana": "\u3084", "/yakatakana": "\u30E4", "/yakatakanahalfwidth": "\uFF94", "/yakorean": "\u3151", "/yamakkanthai": "\u0E4E", "/yangtonemod": "\u02EB", "/yasmallhiragana": "\u3083", "/yasmallkatakana": "\u30E3", "/yasmallkatakanahalfwidth": "\uFF6C", "/yatcyr": "\u0463", "/yatcyrillic": "\u0463", "/ycircle": "\u24E8", "/ycircumflex": "\u0177", "/ydieresis": "\u00FF", "/ydot": "\u1E8F", "/ydotaccent": "\u1E8F", "/ydotbelow": "\u1EF5", "/yeh": "\u064A", "/yeh.fina": "\uFEF2", "/yeh.init": "\uFEF3", "/yeh.init_alefmaksura.fina": "\uFC59", "/yeh.init_hah.fina": "\uFC56", "/yeh.init_hah.medi": "\uFCDB", "/yeh.init_hamzaabove.medi_ae.fina": "\uFBEC", "/yeh.init_hamzaabove.medi_alef.fina": "\uFBEA", "/yeh.init_hamzaabove.medi_alefmaksura.fina": "\uFC03", "/yeh.init_hamzaabove.medi_e.fina": "\uFBF6", "/yeh.init_hamzaabove.medi_e.medi": "\uFBF8", "/yeh.init_hamzaabove.medi_hah.fina": "\uFC01", "/yeh.init_hamzaabove.medi_hah.medi": "\uFC98", "/yeh.init_hamzaabove.medi_heh.medi": "\uFC9B", "/yeh.init_hamzaabove.medi_jeem.fina": "\uFC00", "/yeh.init_hamzaabove.medi_jeem.medi": "\uFC97", "/yeh.init_hamzaabove.medi_khah.medi": "\uFC99", "/yeh.init_hamzaabove.medi_meem.fina": "\uFC02", "/yeh.init_hamzaabove.medi_meem.medi": "\uFC9A", "/yeh.init_hamzaabove.medi_oe.fina": "\uFBF2", "/yeh.init_hamzaabove.medi_u.fina": "\uFBF0", "/yeh.init_hamzaabove.medi_waw.fina": "\uFBEE", "/yeh.init_hamzaabove.medi_yeh.fina": "\uFC04", "/yeh.init_hamzaabove.medi_yu.fina": "\uFBF4", "/yeh.init_heh.medi": "\uFCDE", "/yeh.init_jeem.fina": "\uFC55", "/yeh.init_jeem.medi": "\uFCDA", "/yeh.init_khah.fina": "\uFC57", "/yeh.init_khah.medi": "\uFCDC", "/yeh.init_meem.fina": "\uFC58", "/yeh.init_meem.medi": "\uFCDD", "/yeh.init_meem.medi_meem.medi": "\uFD9D", "/yeh.init_yeh.fina": "\uFC5A", "/yeh.isol": "\uFEF1", "/yeh.medi": "\uFEF4", "/yeh.medi_alefmaksura.fina": "\uFC95", "/yeh.medi_hah.medi_yeh.fina": "\uFDAE", "/yeh.medi_hamzaabove.medi_ae.fina": "\uFBED", "/yeh.medi_hamzaabove.medi_alef.fina": "\uFBEB", "/yeh.medi_hamzaabove.medi_alefmaksura.fina": "\uFC68", "/yeh.medi_hamzaabove.medi_e.fina": "\uFBF7", "/yeh.medi_hamzaabove.medi_heh.medi": "\uFCE0", "/yeh.medi_hamzaabove.medi_meem.fina": "\uFC66", "/yeh.medi_hamzaabove.medi_meem.medi": "\uFCDF", "/yeh.medi_hamzaabove.medi_noon.fina": "\uFC67", "/yeh.medi_hamzaabove.medi_oe.fina": "\uFBF3", "/yeh.medi_hamzaabove.medi_reh.fina": "\uFC64", "/yeh.medi_hamzaabove.medi_u.fina": "\uFBF1", "/yeh.medi_hamzaabove.medi_waw.fina": "\uFBEF", "/yeh.medi_hamzaabove.medi_yeh.fina": "\uFC69", "/yeh.medi_hamzaabove.medi_yu.fina": "\uFBF5", "/yeh.medi_hamzaabove.medi_zain.fina": "\uFC65", "/yeh.medi_heh.medi": "\uFCF1", "/yeh.medi_jeem.medi_yeh.fina": "\uFDAF", "/yeh.medi_meem.fina": "\uFC93", "/yeh.medi_meem.medi": "\uFCF0", "/yeh.medi_meem.medi_meem.fina": "\uFD9C", "/yeh.medi_meem.medi_yeh.fina": "\uFDB0", "/yeh.medi_noon.fina": "\uFC94", "/yeh.medi_reh.fina": "\uFC91", "/yeh.medi_yeh.fina": "\uFC96", "/yeh.medi_zain.fina": "\uFC92", "/yehBarreeDigitThreeAbove": "\u077B", "/yehBarreeDigitTwoAbove": "\u077A", "/yehVabove": "\u06CE", "/yehabove": "\u06E7", "/yeharabic": "\u064A", "/yehbarree": "\u06D2", "/yehbarree.fina": "\uFBAF", "/yehbarree.isol": "\uFBAE", "/yehbarreearabic": "\u06D2", "/yehbarreefinalarabic": "\uFBAF", "/yehbarreehamza": "\u06D3", "/yehbarreehamza.fina": "\uFBB1", "/yehbarreehamza.isol": "\uFBB0", "/yehfarsi": "\u06CC", "/yehfarsi.fina": "\uFBFD", "/yehfarsi.init": "\uFBFE", "/yehfarsi.isol": "\uFBFC", "/yehfarsi.medi": "\uFBFF", "/yehfarsiinvertedV": "\u063D", "/yehfarsithreedotsabove": "\u063F", "/yehfarsitwodotsabove": "\u063E", "/yehfinalarabic": "\uFEF2", "/yehhamza": "\u0626", "/yehhamza.fina": "\uFE8A", "/yehhamza.init": "\uFE8B", "/yehhamza.isol": "\uFE89", "/yehhamza.medi": "\uFE8C", "/yehhamzaabovearabic": "\u0626", "/yehhamzaabovefinalarabic": "\uFE8A", "/yehhamzaaboveinitialarabic": "\uFE8B", "/yehhamzaabovemedialarabic": "\uFE8C", "/yehhighhamza": "\u0678", "/yehinitialarabic": "\uFEF3", "/yehmedialarabic": "\uFEF4", "/yehmeeminitialarabic": "\uFCDD", "/yehmeemisolatedarabic": "\uFC58", "/yehnoonfinalarabic": "\uFC94", "/yehsmall": "\u06E6", "/yehtail": "\u06CD", "/yehthreedotsbelow": "\u06D1", "/yehthreedotsbelowarabic": "\u06D1", "/yekorean": "\u3156", "/yellowHeart": "\u1F49B", "/yen": "\u00A5", "/yenmonospace": "\uFFE5", "/yeokorean": "\u3155", "/yeorinhieuhkorean": "\u3186", "/yerachBenYomo:hb": "\u05AA", "/yerahbenyomohebrew": "\u05AA", "/yerahbenyomolefthebrew": "\u05AA", "/yericyrillic": "\u044B", "/yerudieresiscyrillic": "\u04F9", "/yesieungkorean": "\u3181", "/yesieungpansioskorean": "\u3183", "/yesieungsioskorean": "\u3182", "/yetiv:hb": "\u059A", "/yetivhebrew": "\u059A", "/ygrave": "\u1EF3", "/yhoi": "\u1EF7", "/yhook": "\u01B4", "/yhookabove": "\u1EF7", "/yiarmenian": "\u0575", "/yicyrillic": "\u0457", "/yikorean": "\u3162", "/yintonemod": "\u02EA", "/yinyang": "\u262F", "/yiwnarmenian": "\u0582", "/ylongcyr": "\u044B", "/ylongdieresiscyr": "\u04F9", "/yloop": "\u1EFF", "/ymacron": "\u0233", "/ymonospace": "\uFF59", "/yocirclekatakana": "\u32F5", "/yod": "\u05D9", "/yod:hb": "\u05D9", "/yod_yod:hb": "\u05F2", "/yod_yod_patah:hb": "\uFB1F", "/yoddagesh": "\uFB39", "/yoddageshhebrew": "\uFB39", "/yodhebrew": "\u05D9", "/yodwithdagesh:hb": "\uFB39", "/yodwithhiriq:hb": "\uFB1D", "/yodyodhebrew": "\u05F2", "/yodyodpatahhebrew": "\uFB1F", "/yogh": "\u021D", "/yohiragana": "\u3088", "/yoikorean": "\u3189", "/yokatakana": "\u30E8", "/yokatakanahalfwidth": "\uFF96", "/yokorean": "\u315B", "/yosmallhiragana": "\u3087", "/yosmallkatakana": "\u30E7", "/yosmallkatakanahalfwidth": "\uFF6E", "/yot": "\u03F3", "/yotgreek": "\u03F3", "/yoyaekorean": "\u3188", "/yoyakorean": "\u3187", "/yoyakthai": "\u0E22", "/yoyingthai": "\u0E0D", "/yparen": "\u24B4", "/yparenthesized": "\u24B4", "/ypogegrammeni": "\u037A", "/ypogegrammenigreekcmb": "\u0345", "/yr": "\u01A6", "/yring": "\u1E99", "/ystroke": "\u024F", "/ysuperior": "\u02B8", "/ysupmod": "\u02B8", "/ytilde": "\u1EF9", "/yturned": "\u028E", "/yu.fina": "\uFBDC", "/yu.isol": "\uFBDB", "/yuansquare": "\u3350", "/yucirclekatakana": "\u32F4", "/yucyr": "\u044E", "/yuhiragana": "\u3086", "/yuikorean": "\u318C", "/yukatakana": "\u30E6", "/yukatakanahalfwidth": "\uFF95", "/yukirghiz": "\u06C9", "/yukirghiz.fina": "\uFBE3", "/yukirghiz.isol": "\uFBE2", "/yukorean": "\u3160", "/yukrcyr": "\u0457", "/yusbigcyr": "\u046B", "/yusbigcyrillic": "\u046B", "/yusbigiotifiedcyr": "\u046D", "/yusbigiotifiedcyrillic": "\u046D", "/yuslittlecyr": "\u0467", "/yuslittlecyrillic": "\u0467", "/yuslittleiotifiedcyr": "\u0469", "/yuslittleiotifiedcyrillic": "\u0469", "/yusmallhiragana": "\u3085", "/yusmallkatakana": "\u30E5", "/yusmallkatakanahalfwidth": "\uFF6D", "/yuyekorean": "\u318B", "/yuyeokorean": "\u318A", "/yyabengali": "\u09DF", "/yyadeva": "\u095F", "/z": "\u007A", "/zaarmenian": "\u0566", "/zacute": "\u017A", "/zadeva": "\u095B", "/zagurmukhi": "\u0A5B", "/zah": "\u0638", "/zah.fina": "\uFEC6", "/zah.init": "\uFEC7", "/zah.init_meem.fina": "\uFC28", "/zah.init_meem.medi": "\uFCB9", "/zah.isol": "\uFEC5", "/zah.medi": "\uFEC8", "/zah.medi_meem.medi": "\uFD3B", "/zaharabic": "\u0638", "/zahfinalarabic": "\uFEC6", "/zahinitialarabic": "\uFEC7", "/zahiragana": "\u3056", "/zahmedialarabic": "\uFEC8", "/zain": "\u0632", "/zain.fina": "\uFEB0", "/zain.isol": "\uFEAF", "/zainabove": "\u0617", "/zainarabic": "\u0632", "/zainfinalarabic": "\uFEB0", "/zakatakana": "\u30B6", "/zaqefGadol:hb": "\u0595", "/zaqefQatan:hb": "\u0594", "/zaqefgadolhebrew": "\u0595", "/zaqefqatanhebrew": "\u0594", "/zarqa:hb": "\u0598", "/zarqahebrew": "\u0598", "/zayin": "\u05D6", "/zayin:hb": "\u05D6", "/zayindagesh": "\uFB36", "/zayindageshhebrew": "\uFB36", "/zayinhebrew": "\u05D6", "/zayinwithdagesh:hb": "\uFB36", "/zbopomofo": "\u3117", "/zcaron": "\u017E", "/zcircle": "\u24E9", "/zcircumflex": "\u1E91", "/zcurl": "\u0291", "/zdescender": "\u2C6C", "/zdot": "\u017C", "/zdotaccent": "\u017C", "/zdotbelow": "\u1E93", "/zecyr": "\u0437", "/zecyrillic": "\u0437", "/zedescendercyrillic": "\u0499", "/zedieresiscyr": "\u04DF", "/zedieresiscyrillic": "\u04DF", "/zehiragana": "\u305C", "/zekatakana": "\u30BC", "/zero": "\u0030", "/zero.inferior": "\u2080", "/zero.superior": "\u2070", "/zeroarabic": "\u0660", "/zerobengali": "\u09E6", "/zerocircle": "\u24EA", "/zerocircleblack": "\u24FF", "/zerocomma": "\u1F101", "/zerodeva": "\u0966", "/zerofar": "\u06F0", "/zerofullstop": "\u1F100", "/zerogujarati": "\u0AE6", "/zerogurmukhi": "\u0A66", "/zerohackarabic": "\u0660", "/zeroinferior": "\u2080", "/zeromonospace": "\uFF10", "/zerooldstyle": "\uF730", "/zeropersian": "\u06F0", "/zerosquareabove": "\u06E0", "/zerosuperior": "\u2070", "/zerothai": "\u0E50", "/zerothirds": "\u2189", "/zerowidthjoiner": "\uFEFF", "/zerowidthnobreakspace": "\uFEFF", "/zerowidthnonjoiner": "\u200C", "/zerowidthspace": "\u200B", "/zeta": "\u03B6", "/zetailcyr": "\u0499", "/zhbopomofo": "\u3113", "/zhearmenian": "\u056A", "/zhebrevecyr": "\u04C2", "/zhebrevecyrillic": "\u04C2", "/zhecyr": "\u0436", "/zhecyrillic": "\u0436", "/zhedescendercyrillic": "\u0497", "/zhedieresiscyr": "\u04DD", "/zhedieresiscyrillic": "\u04DD", "/zhetailcyr": "\u0497", "/zhook": "\u0225", "/zihiragana": "\u3058", "/zikatakana": "\u30B8", "/zildefunc": "\u236C", "/zinorhebrew": "\u05AE", "/zjekomicyr": "\u0505", "/zlinebelow": "\u1E95", "/zmonospace": "\uFF5A", "/znotationbagmembership": "\u22FF", "/zohiragana": "\u305E", "/zokatakana": "\u30BE", "/zparen": "\u24B5", "/zparenthesized": "\u24B5", "/zretroflex": "\u0290", "/zretroflexhook": "\u0290", "/zstroke": "\u01B6", "/zswashtail": "\u0240", "/zuhiragana": "\u305A", "/zukatakana": "\u30BA", "/zwarakay": "\u0659", # manually added from # https://github.com/serviceprototypinglab/latex-pdfa/blob/master/glyphtounicode-cmr.tex "/angbracketleftBig": "\u28E8", "/angbracketleftBigg": "\u27E8", "/angbracketleftbig": "\u27E8", "/angbracketleftbigg": "\u27E8", "/angbracketrightBig": "\u27E9", "/angbracketrightBigg": "\u27E9", "/angbracketrightbig": "\u27E9", "/angbracketrightbigg": "\u27E9", "/arrowbt": "\u2193", "/arrowdblbt": "\u21D3", "/arrowdbltp": "\u21D1", "/arrowhookleft": "\u21AA", "/arrowhookright": "\u21A9", "/arrowtp": "\u2191", # diff : "/arrowvertex": "\u23D0", "/arrowvertexdbl": "\uED12", "/backslashBig": "\u005C", "/backslashBigg": "\u005C", "/backslashbig": "\u005C", "/backslashbigg": "\u005C", # diff : "/braceex": "\u23AA", "/bracehtipdownleft": "\uED17", "/bracehtipdownright": "\uED18", "/bracehtipupleft": "\uED19", "/bracehtipupright": "\uED1A", "/braceleftBig": "\u007B", "/braceleftBigg": "\u007B", "/braceleftbig": "\u007B", "/braceleftbigg": "\u007B", # diff : "/braceleftbt": "\u23A9", # diff : "/braceleftmid": "\u23A8", # diff : "/bracelefttp": "\u23A7", "/bracerightBig": "\u007D", "/bracerightBigg": "\u007D", "/bracerightbig": "\u007D", "/bracerightbigg": "\u007D", # diff : "/bracerightbt": "\u23AD", # diff : "/bracerightmid": "\u23AC", # diff : "/bracerighttp": "\u23AB", "/bracketleftBig": "\u005B", "/bracketleftBigg": "\u005B", "/bracketleftbig": "\u005B", "/bracketleftbigg": "\u005B", # diff : "/bracketleftbt": "\u23A3", # diff : "/bracketleftex": "\u23A2", # diff : "/bracketlefttp": "\u23A1", "/bracketrightBig": "\u005D", "/bracketrightBigg": "\u005D", "/bracketrightbig": "\u005D", "/bracketrightbigg": "\u005D", # diff : "/bracketrightbt": "\u23A6", # diff : "/bracketrightex": "\u23A5", # diff : "/bracketrighttp": "\u23A4", "/ceilingleftBig": "\u2308", "/ceilingleftBigg": "\u2308", "/ceilingleftbig": "\u2308", "/ceilingleftbigg": "\u2308", "/ceilingrightBig": "\u2309", "/ceilingrightBigg": "\u2309", "/ceilingrightbig": "\u2309", "/ceilingrightbigg": "\u2309", "/circledotdisplay": "\u2A00", "/circledottext": "\u2A00", "/circlemultiplydisplay": "\u2A02", "/circlemultiplytext": "\u2A02", "/circleplusdisplay": "\u2A01", "/circleplustext": "\u2A01", "/contintegraldisplay": "\u222E", "/contintegraltext": "\u222E", "/coproductdisplay": "\u2210", "/coproducttext": "\u2210", "/floorleftBig": "\u230A", "/floorleftBigg": "\u230A", "/floorleftbig": "\u230A", "/floorleftbigg": "\u230A", "/floorrightBig": "\u230B", "/floorrightBigg": "\u230B", "/floorrightbig": "\u230B", "/floorrightbigg": "\u230B", "/hatwide": "\u02C6", "/hatwider": "\u02C6", "/hatwidest": "\u02C6", "/integraldisplay": "\u222B", "/integraltext": "\u222B", "/intersectiondisplay": "\u22C2", "/intersectiontext": "\u22C2", "/logicalanddisplay": "\u22C0", "/logicalandtext": "\u22C0", "/logicalordisplay": "\u22C1", "/logicalortext": "\u22C1", "/mapsto": "\u21A6", "/parenleftBig": "\u0028", "/parenleftBigg": "\u0028", "/parenleftbig": "\u0028", "/parenleftbigg": "\u0028", # diff : "/parenleftbt": "\u239D", # diff : "/parenleftex": "\u239C", # diff : "/parenlefttp": "\u239B", "/parenrightBig": "\u0029", "/parenrightBigg": "\u0029", "/parenrightbig": "\u0029", "/parenrightbigg": "\u0029", # diff : "/parenrightbt": "\u23A0", # diff : "/parenrightex": "\u239F", # diff : "/parenrighttp": "\u239E", "/productdisplay": "\u220F", "/producttext": "\u220F", "/radicalBig": "\u221A", "/radicalBigg": "\u221A", "/radicalbig": "\u221A", "/radicalbigg": "\u221A", "/radicalbt": "\u221A", "/radicaltp": "\uED6A", "/radicalvertex": "\uED6B", "/slashBig": "\u002F", "/slashBigg": "\u002F", "/slashbig": "\u002F", "/slashbigg": "\u002F", "/summationdisplay": "\u2211", "/summationtext": "\u2211", "/tie": "\u2040", "/tildewide": "\u02DC", "/tildewider": "\u02DC", "/tildewidest": "\u02DC", "/uniondisplay": "\u22C3", "/unionmultidisplay": "\u2A04", "/unionmultitext": "\u2A04", "/unionsqdisplay": "\u2A06", "/unionsqtext": "\u2A06", "/uniontext": "\u22C3", "/vextenddouble": "\uED79", "/vextendsingle": "\u23D0", "/a1": "\u25C1", "/a2": "\u22B4", "/a3": "\u25B7", "/a4": "\u22B5", "/a40": "\u02C2", "/a41": "\u02C3", "/a42": "\u2303", "/a43": "\u2304", "/a48": "\u2127", "/a49": "\u22C8", "/a50": "\u25A1", "/a51": "\u25C7", "/a58": "\u2053", "/a59": "\u219D", "/a60": "\u228F", "/a61": "\u2290", "/d0": "\u2199", "/d1": "\u2199", "/d2": "\u2199", "/d3": "\u2199", "/d4": "\u2199", "/d5": "\u2199", "/d6": "\u2199", "/d7": "\u2193", "/d8": "\u2193", "/d9": "\u2193", "/d10": "\u2193", "/d11": "\u2193", "/d12": "\u2193", "/d13": "\u2193", "/d14": "\u2193", "/d15": "\u2193", "/d16": "\u2193", "/d17": "\u2193", "/d18": "\u2193", "/d19": "\u2193", "/d20": "\u2193", "/d21": "\u2193", "/d22": "\u2193", "/d23": "\u2193", "/d24": "\u2198", "/d25": "\u2198", "/d26": "\u2198", "/d27": "\u2198", "/d28": "\u2198", "/d29": "\u2198", "/d30": "\u2198", "/d31": "\u2198", "/d32": "\u2198", "/d33": "\u2198", "/d34": "\u2198", "/d35": "\u2198", "/d36": "\u2198", "/d37": "\u2198", "/d38": "\u2198", "/d39": "\u2192", "/d40": "\u2192", "/d41": "\u2192", "/d42": "\u2192", "/d43": "\u2192", "/d44": "\u2192", "/d45": "\u2192", "/d46": "\u2192", "/d47": "\u2192", "/d48": "\u2192", "/d49": "\u2192", "/d50": "\u2192", "/d51": "\u2192", "/d52": "\u2192", "/d53": "\u2192", "/d54": "\u2192", "/d55": "\u2192", "/d56": "\u2197", "/d57": "\u2197", "/d58": "\u2197", "/d59": "\u2197", "/d60": "\u2197", "/d61": "\u2197", "/d62": "\u2197", "/d63": "\u2197", "/d64": "\u2197", "/d65": "\u2197", "/d66": "\u2197", "/d67": "\u2197", "/d68": "\u2197", "/d69": "\u2197", "/d70": "\u2197", "/d71": "\u2191", "/d72": "\u2191", "/d73": "\u2191", "/d74": "\u2191", "/d75": "\u2191", "/d76": "\u2191", "/d77": "\u2191", "/d78": "\u2191", "/d79": "\u2191", "/d80": "\u2191", "/d81": "\u2191", "/d82": "\u2191", "/d83": "\u2191", "/d84": "\u2191", "/d85": "\u2191", "/d86": "\u2191", "/d87": "\u2191", "/d88": "\u2196", "/d89": "\u2196", "/d90": "\u2196", "/d91": "\u2196", "/d92": "\u2196", "/d93": "\u2196", "/d94": "\u2196", "/d95": "\u2196", "/d96": "\u2196", "/d97": "\u2196", "/d98": "\u2196", "/d99": "\u2196", "/d100": "\u2196", "/d101": "\u2196", "/d102": "\u2196", "/d103": "\u2190", "/d104": "\u2190", "/d105": "\u2190", "/d106": "\u2190", "/d107": "\u2190", "/d108": "\u2190", "/d109": "\u2190", "/d110": "\u2190", "/d111": "\u2190", "/d112": "\u2190", "/d113": "\u2190", "/d114": "\u2190", "/d115": "\u2190", "/d116": "\u2190", "/d117": "\u2190", "/d118": "\u2190", "/d119": "\u2190", "/d120": "\u2199", "/d121": "\u2199", "/d122": "\u2199", "/d123": "\u2199", "/d124": "\u2199", "/d125": "\u2199", "/d126": "\u2199", "/d127": "\u2199", # manually added from # https://github.com/kohler/lcdf-typetools/blob/master/texglyphlist.txt "/Ifractur": "\u2111", "/FFsmall": "\uF766", "/FFIsmall": "\uF766", "/FFLsmall": "\uF766", "/FIsmall": "\uF766", "/FLsmall": "\uF766", # diff : "/Germandbls": "\u0053", "/Germandblssmall": "\uF773", "/Ng": "\u014A", "/Rfractur": "\u211C", "/SS": "\u0053", "/SSsmall": "\uF773", "/altselector": "\uD802", "/angbracketleft": "\u27E8", "/angbracketright": "\u27E9", "/arrowbothv": "\u2195", "/arrowdblbothv": "\u21D5", "/arrowleftbothalf": "\u21BD", "/arrowlefttophalf": "\u21BC", "/arrownortheast": "\u2197", "/arrownorthwest": "\u2196", "/arrowrightbothalf": "\u21C1", "/arrowrighttophalf": "\u21C0", "/arrowsoutheast": "\u2198", "/arrowsouthwest": "\u2199", "/ascendercompwordmark": "\uD80A", "/asteriskcentered": "\u2217", "/bardbl": "\u2225", "/capitalcompwordmark": "\uD809", "/circlecopyrt": "\u20DD", "/circledivide": "\u2298", "/circleminus": "\u2296", "/coproduct": "\u2A3F", "/ct": "\u0063", "/cwm": "\u200C", "/dblbracketleft": "\u27E6", "/dblbracketright": "\u27E7", # diff : "/diamond": "\u2662", "/diamondmath": "\u22C4", # diff : "/dotlessj": "\u0237", "/emptyslot": "\uD801", "/epsilon1": "\u03F5", "/epsiloninv": "\u03F6", "/equivasymptotic": "\u224D", "/flat": "\u266D", "/follows": "\u227B", "/followsequal": "\u2AB0", "/followsorcurly": "\u227D", "/greatermuch": "\u226B", # diff : "/heart": "\u2661", "/interrobangdown": "\u2E18", "/intersectionsq": "\u2293", "/latticetop": "\u22A4", "/lessmuch": "\u226A", "/longdbls": "\u017F", "/longsh": "\u017F", "/longsi": "\u017F", "/longsl": "\u017F", "/longst": "\uFB05", "/lscript": "\u2113", "/natural": "\u266E", "/negationslash": "\u0338", "/ng": "\u014B", "/owner": "\u220B", "/pertenthousand": "\u2031", # diff : "/phi": "\u03D5", # diff : "/phi1": "\u03C6", "/pi1": "\u03D6", "/precedesequal": "\u2AAF", "/precedesorcurly": "\u227C", "/prime": "\u2032", "/rho1": "\u03F1", "/ringfitted": "\uD80D", "/sharp": "\u266F", "/similarequal": "\u2243", "/slurabove": "\u2322", "/slurbelow": "\u2323", "/st": "\uFB06", "/subsetsqequal": "\u2291", "/supersetsqequal": "\u2292", "/triangle": "\u25B3", "/triangleinv": "\u25BD", "/triangleleft": "\u25C1", # diff : "/triangleright": "\u25B7", "/turnstileleft": "\u22A2", "/turnstileright": "\u22A3", "/twelveudash": "\uD80C", "/unionmulti": "\u228E", "/unionsq": "\u2294", "/vector": "\u20D7", "/visualspace": "\u2423", "/Dbar": "\u0110", "/compwordmark": "\u200C", "/dbar": "\u0111", "/rangedash": "\u2013", "/hyphenchar": "\u002D", "/punctdash": "\u2014", "/visiblespace": "\u2423", "/Yen": "\u00A5", "/anticlockwise": "\u27F2", "/arrowparrleftright": "\u21C6", "/arrowparrrightleft": "\u21C4", "/arrowtailleft": "\u21A2", "/arrowtailright": "\u21A3", "/arrowtripleleft": "\u21DA", "/arrowtripleright": "\u21DB", "/check": "\u2713", "/circleR": "\u00AE", "/circleS": "\u24C8", "/circleasterisk": "\u229B", "/circleequal": "\u229C", "/circlering": "\u229A", "/clockwise": "\u27F3", "/curlyleft": "\u21AB", "/curlyright": "\u21AC", "/dblarrowdwn": "\u21CA", "/dblarrowheadleft": "\u219E", "/dblarrowheadright": "\u21A0", # diff : "/dblarrowup": "\u21C8", "/defines": "\u225C", "/diamondsolid": "\u2666", "/difference": "\u224F", "/downfall": "\u22CE", "/equaldotleftright": "\u2252", "/equaldotrightleft": "\u2253", "/equalorfollows": "\u22DF", # diff : "/equalorgreater": "\u2A96", # diff : "/equalorless": "\u2A95", "/equalsdots": "\u2251", "/followsorequal": "\u227F", "/forcesbar": "\u22AA", # diff : "/fork": "\u22D4", "/geomequivalent": "\u224E", "/greaterdbleqlless": "\u2A8C", "/greaterdblequal": "\u2267", "/greaterlessequal": "\u22DB", "/greaterorapproxeql": "\u2A86", "/greaterorequalslant": "\u2A7E", "/greaterorsimilar": "\u2273", "/harpoondownleft": "\u21C3", "/harpoondownright": "\u21C2", "/harpoonleftright": "\u21CC", "/harpoonrightleft": "\u21CB", "/harpoonupleft": "\u21BF", "/harpoonupright": "\u21BE", "/intercal": "\u22BA", "/lessdbleqlgreater": "\u2A8B", "/lessdblequal": "\u2266", "/lessequalgreater": "\u22DA", "/lessorapproxeql": "\u2A85", "/lessorequalslant": "\u2A7D", "/lessorsimilar": "\u2272", "/maltesecross": "\u2720", "/multiopenleft": "\u22CB", "/multiopenright": "\u22CC", "/orunderscore": "\u22BB", "/perpcorrespond": "\u2A5E", # diff : "/precedesorequal": "\u227E", "/primereverse": "\u2035", "/revasymptequal": "\u22CD", "/revsimilar": "\u223D", "/rightanglene": "\u231D", "/rightanglenw": "\u231C", "/rightanglese": "\u231F", "/rightanglesw": "\u231E", "/satisfies": "\u22A8", "/shiftleft": "\u21B0", "/shiftright": "\u21B1", "/square": "\u25A1", "/squaredot": "\u22A1", "/squareminus": "\u229F", "/squaremultiply": "\u22A0", "/squareplus": "\u229E", "/squaresolid": "\u25A0", "/squiggleleftright": "\u21AD", "/squiggleright": "\u21DD", "/subsetdblequal": "\u2AC5", "/supersetdbl": "\u22D1", "/supersetdblequal": "\u2AC6", "/triangledownsld": "\u25BC", "/triangleleftequal": "\u22B4", "/triangleleftsld": "\u25C0", "/trianglerightequal": "\u22B5", "/trianglerightsld": "\u25B6", "/trianglesolid": "\u25B2", "/uprise": "\u22CF", # diff : "/Digamma": "\u1D7C", "/Finv": "\u2132", "/Gmir": "\u2141", "/Omegainv": "\u2127", "/approxorequal": "\u224A", "/archleftdown": "\u21B6", "/archrightdown": "\u21B7", "/beth": "\u2136", "/daleth": "\u2138", "/dividemultiply": "\u22C7", "/downslope": "\u29F9", "/equalorsimilar": "\u2242", "/follownotdbleqv": "\u2ABA", "/follownotslnteql": "\u2AB6", "/followornoteqvlnt": "\u22E9", "/greaternotdblequal": "\u2A8A", "/greaternotequal": "\u2A88", "/greaterornotdbleql": "\u2269", "/greaterornotequal": "\u2269", "/integerdivide": "\u2216", "/lessnotdblequal": "\u2A89", "/lessnotequal": "\u2A87", "/lessornotdbleql": "\u2268", "/lessornotequal": "\u2268", "/multicloseleft": "\u22C9", "/multicloseright": "\u22CA", "/notapproxequal": "\u2247", "/notarrowboth": "\u21AE", "/notarrowleft": "\u219A", "/notarrowright": "\u219B", "/notbar": "\u2224", "/notdblarrowboth": "\u21CE", "/notdblarrowleft": "\u21CD", "/notdblarrowright": "\u21CF", "/notfollows": "\u2281", "/notfollowsoreql": "\u2AB0", "/notforces": "\u22AE", "/notforcesextra": "\u22AF", "/notgreaterdblequal": "\u2267", "/notgreaterequal": "\u2271", "/notgreaterorslnteql": "\u2A7E", "/notlessdblequal": "\u2266", "/notlessequal": "\u2270", "/notlessorslnteql": "\u2A7D", "/notprecedesoreql": "\u2AAF", "/notsatisfies": "\u22AD", "/notsimilar": "\u2241", "/notsubseteql": "\u2288", "/notsubsetordbleql": "\u2AC5", "/notsubsetoreql": "\u228A", "/notsuperseteql": "\u2289", "/notsupersetordbleql": "\u2AC6", "/notsupersetoreql": "\u228B", "/nottriangeqlleft": "\u22EC", "/nottriangeqlright": "\u22ED", "/nottriangleleft": "\u22EA", "/nottriangleright": "\u22EB", "/notturnstile": "\u22AC", "/planckover2pi": "\u210F", "/planckover2pi1": "\u210F", "/precedenotdbleqv": "\u2AB9", "/precedenotslnteql": "\u2AB5", "/precedeornoteqvlnt": "\u22E8", "/subsetnoteql": "\u228A", "/subsetornotdbleql": "\u2ACB", "/supersetnoteql": "\u228B", "/supersetornotdbleql": "\u2ACC", "/upslope": "\u29F8", } def _complete() -> None: for i in range(256): adobe_glyphs[f"/a{i}"] = chr(i) adobe_glyphs["/.notdef"] = "â–ˇ" _complete() pypdf-6.1.2/pypdf/_codecs/core_fontmetrics.py000066400000000000000000003351651507516550200213250ustar00rootroot00000000000000# This file is based upon the 14 core AFM files provided by Adobe/Macromedia at # https://download.macromedia.com/pub/developer/opentype/tech-notes/Core14_AFMs.zip # The original copyright follows: # # ----------------------------------------------------------------------------------------------- # Core 14 AFM Files - ReadMe # # This file and the 14 PostScript(R) AFM files it accompanies may be used, copied, and # distributed for any purpose and without charge, with or without modification, provided that all # copyright notices are retained; that the AFM files are not distributed without this file; that # all modifications to this file or any of the AFM files are prominently noted in the modified # file(s); and that this paragraph is not modified. Adobe Systems has no responsibility or # obligation to support the use of the AFM files. # ----------------------------------------------------------------------------------------------- from pypdf._font import FontDescriptor CORE_FONT_METRICS: dict[str, FontDescriptor] = { # Generated from Courier.afm # Copyright (c) 1989, 1990, 1991, 1992, 1993, 1997 Adobe Systems Incorporated. All Rights # Reserved. "Courier": FontDescriptor( name="Courier", family="Courier", weight="Medium", ascent=629, descent=-157, cap_height=562, x_height=426, italic_angle=0, flags=33, bbox=(-23.0, -250.0, 715.0, 805.0), character_widths={ " ": 600, "!": 600, '"': 600, "#": 600, "$": 600, "%": 600, "&": 600, "\u2019": 600, "(": 600, ")": 600, "*": 600, "+": 600, ",": 600, "-": 600, ".": 600, "/": 600, "0": 600, "1": 600, "2": 600, "3": 600, "4": 600, "5": 600, "6": 600, "7": 600, "8": 600, "9": 600, ":": 600, ";": 600, "<": 600, "=": 600, ">": 600, "?": 600, "@": 600, "A": 600, "B": 600, "C": 600, "D": 600, "E": 600, "F": 600, "G": 600, "H": 600, "I": 600, "J": 600, "K": 600, "L": 600, "M": 600, "N": 600, "O": 600, "P": 600, "Q": 600, "R": 600, "S": 600, "T": 600, "U": 600, "V": 600, "W": 600, "X": 600, "Y": 600, "Z": 600, "[": 600, "\\": 600, "]": 600, "^": 600, "_": 600, "\u2018": 600, "a": 600, "b": 600, "c": 600, "d": 600, "e": 600, "f": 600, "g": 600, "h": 600, "i": 600, "j": 600, "k": 600, "l": 600, "m": 600, "n": 600, "o": 600, "p": 600, "q": 600, "r": 600, "s": 600, "t": 600, "u": 600, "v": 600, "w": 600, "x": 600, "y": 600, "z": 600, "{": 600, "|": 600, "}": 600, "~": 600, "\xa1": 600, "\xa2": 600, "\xa3": 600, "\u2044": 600, "\xa5": 600, "\u0192": 600, "\xa7": 600, "\xa4": 600, "'": 600, "\u201c": 600, "\xab": 600, "\u2039": 600, "\u203a": 600, "\ufb01": 600, "\ufb02": 600, "\u2013": 600, "\u2020": 600, "\u2021": 600, "\xb7": 600, "\xb6": 600, "\u2022": 600, "\u201a": 600, "\u201e": 600, "\u201d": 600, "\xbb": 600, "\u2026": 600, "\u2030": 600, "\xbf": 600, "`": 600, "\xb4": 600, "\u02c6": 600, "\u02dc": 600, "\xaf": 600, "\u02d8": 600, "\u02d9": 600, "\xa8": 600, "\u02da": 600, "\xb8": 600, "\u02dd": 600, "\u02db": 600, "\u02c7": 600, "\u2014": 600, "\xc6": 600, "\xaa": 600, "\u0141": 600, "\xd8": 600, "\u0152": 600, "\xba": 600, "\xe6": 600, "\u0131": 600, "\u0142": 600, "\xf8": 600, "\u0153": 600, "\xdf": 600, "\xcf": 600, "\xe9": 600, "\u0103": 600, "\u0171": 600, "\u011b": 600, "\u0178": 600, "\xf7": 600, "\xdd": 600, "\xc2": 600, "\xe1": 600, "\xdb": 600, "\xfd": 600, "\u0219": 600, "\xea": 600, "\u016e": 600, "\xdc": 600, "\u0105": 600, "\xda": 600, "\u0173": 600, "\xcb": 600, "\u0110": 600, "\uf6c3": 600, "\xa9": 600, "\u0112": 600, "\u010d": 600, "\xe5": 600, "\u0145": 600, "\u013a": 600, "\xe0": 600, "\u0162": 600, "\u0106": 600, "\xe3": 600, "\u0116": 600, "\u0161": 600, "\u015f": 600, "\xed": 600, "\u25ca": 600, "\u0158": 600, "\u0122": 600, "\xfb": 600, "\xe2": 600, "\u0100": 600, "\u0159": 600, "\xe7": 600, "\u017b": 600, "\xde": 600, "\u014c": 600, "\u0154": 600, "\u015a": 600, "\u010f": 600, "\u016a": 600, "\u016f": 600, "\xb3": 600, "\xd2": 600, "\xc0": 600, "\u0102": 600, "\xd7": 600, "\xfa": 600, "\u0164": 600, "\u2202": 600, "\xff": 600, "\u0143": 600, "\xee": 600, "\xca": 600, "\xe4": 600, "\xeb": 600, "\u0107": 600, "\u0144": 600, "\u016b": 600, "\u0147": 600, "\xcd": 600, "\xb1": 600, "\xa6": 600, "\xae": 600, "\u011e": 600, "\u0130": 600, "\u2211": 600, "\xc8": 600, "\u0155": 600, "\u014d": 600, "\u0179": 600, "\u017d": 600, "\u2265": 600, "\xd0": 600, "\xc7": 600, "\u013c": 600, "\u0165": 600, "\u0119": 600, "\u0172": 600, "\xc1": 600, "\xc4": 600, "\xe8": 600, "\u017a": 600, "\u012f": 600, "\xd3": 600, "\xf3": 600, "\u0101": 600, "\u015b": 600, "\xef": 600, "\xd4": 600, "\xd9": 600, "\u2206": 600, "\xfe": 600, "\xb2": 600, "\xd6": 600, "\xb5": 600, "\xec": 600, "\u0151": 600, "\u0118": 600, "\u0111": 600, "\xbe": 600, "\u015e": 600, "\u013e": 600, "\u0136": 600, "\u0139": 600, "\u2122": 600, "\u0117": 600, "\xcc": 600, "\u012a": 600, "\u013d": 600, "\xbd": 600, "\u2264": 600, "\xf4": 600, "\xf1": 600, "\u0170": 600, "\xc9": 600, "\u0113": 600, "\u011f": 600, "\xbc": 600, "\u0160": 600, "\u0218": 600, "\u0150": 600, "\xb0": 600, "\xf2": 600, "\u010c": 600, "\xf9": 600, "\u221a": 600, "\u010e": 600, "\u0157": 600, "\xd1": 600, "\xf5": 600, "\u0156": 600, "\u013b": 600, "\xc3": 600, "\u0104": 600, "\xc5": 600, "\xd5": 600, "\u017c": 600, "\u011a": 600, "\u012e": 600, "\u0137": 600, "\u2212": 600, "\xce": 600, "\u0148": 600, "\u0163": 600, "\xac": 600, "\xf6": 600, "\xfc": 600, "\u2260": 600, "\u0123": 600, "\xf0": 600, "\u017e": 600, "\u0146": 600, "\xb9": 600, "\u012b": 600, "\u20ac": 600, }, ), # Generated from Courier-Bold.afm # Copyright (c) 1989, 1990, 1991, 1993, 1997 Adobe Systems Incorporated. All Rights Reserved. "Courier-Bold": FontDescriptor( name="Courier-Bold", family="Courier", weight="Bold", ascent=629, descent=-157, cap_height=562, x_height=439, italic_angle=0, flags=33, bbox=(-113.0, -250.0, 749.0, 801.0), character_widths={ " ": 600, "!": 600, '"': 600, "#": 600, "$": 600, "%": 600, "&": 600, "\u2019": 600, "(": 600, ")": 600, "*": 600, "+": 600, ",": 600, "-": 600, ".": 600, "/": 600, "0": 600, "1": 600, "2": 600, "3": 600, "4": 600, "5": 600, "6": 600, "7": 600, "8": 600, "9": 600, ":": 600, ";": 600, "<": 600, "=": 600, ">": 600, "?": 600, "@": 600, "A": 600, "B": 600, "C": 600, "D": 600, "E": 600, "F": 600, "G": 600, "H": 600, "I": 600, "J": 600, "K": 600, "L": 600, "M": 600, "N": 600, "O": 600, "P": 600, "Q": 600, "R": 600, "S": 600, "T": 600, "U": 600, "V": 600, "W": 600, "X": 600, "Y": 600, "Z": 600, "[": 600, "\\": 600, "]": 600, "^": 600, "_": 600, "\u2018": 600, "a": 600, "b": 600, "c": 600, "d": 600, "e": 600, "f": 600, "g": 600, "h": 600, "i": 600, "j": 600, "k": 600, "l": 600, "m": 600, "n": 600, "o": 600, "p": 600, "q": 600, "r": 600, "s": 600, "t": 600, "u": 600, "v": 600, "w": 600, "x": 600, "y": 600, "z": 600, "{": 600, "|": 600, "}": 600, "~": 600, "\xa1": 600, "\xa2": 600, "\xa3": 600, "\u2044": 600, "\xa5": 600, "\u0192": 600, "\xa7": 600, "\xa4": 600, "'": 600, "\u201c": 600, "\xab": 600, "\u2039": 600, "\u203a": 600, "\ufb01": 600, "\ufb02": 600, "\u2013": 600, "\u2020": 600, "\u2021": 600, "\xb7": 600, "\xb6": 600, "\u2022": 600, "\u201a": 600, "\u201e": 600, "\u201d": 600, "\xbb": 600, "\u2026": 600, "\u2030": 600, "\xbf": 600, "`": 600, "\xb4": 600, "\u02c6": 600, "\u02dc": 600, "\xaf": 600, "\u02d8": 600, "\u02d9": 600, "\xa8": 600, "\u02da": 600, "\xb8": 600, "\u02dd": 600, "\u02db": 600, "\u02c7": 600, "\u2014": 600, "\xc6": 600, "\xaa": 600, "\u0141": 600, "\xd8": 600, "\u0152": 600, "\xba": 600, "\xe6": 600, "\u0131": 600, "\u0142": 600, "\xf8": 600, "\u0153": 600, "\xdf": 600, "\xcf": 600, "\xe9": 600, "\u0103": 600, "\u0171": 600, "\u011b": 600, "\u0178": 600, "\xf7": 600, "\xdd": 600, "\xc2": 600, "\xe1": 600, "\xdb": 600, "\xfd": 600, "\u0219": 600, "\xea": 600, "\u016e": 600, "\xdc": 600, "\u0105": 600, "\xda": 600, "\u0173": 600, "\xcb": 600, "\u0110": 600, "\uf6c3": 600, "\xa9": 600, "\u0112": 600, "\u010d": 600, "\xe5": 600, "\u0145": 600, "\u013a": 600, "\xe0": 600, "\u0162": 600, "\u0106": 600, "\xe3": 600, "\u0116": 600, "\u0161": 600, "\u015f": 600, "\xed": 600, "\u25ca": 600, "\u0158": 600, "\u0122": 600, "\xfb": 600, "\xe2": 600, "\u0100": 600, "\u0159": 600, "\xe7": 600, "\u017b": 600, "\xde": 600, "\u014c": 600, "\u0154": 600, "\u015a": 600, "\u010f": 600, "\u016a": 600, "\u016f": 600, "\xb3": 600, "\xd2": 600, "\xc0": 600, "\u0102": 600, "\xd7": 600, "\xfa": 600, "\u0164": 600, "\u2202": 600, "\xff": 600, "\u0143": 600, "\xee": 600, "\xca": 600, "\xe4": 600, "\xeb": 600, "\u0107": 600, "\u0144": 600, "\u016b": 600, "\u0147": 600, "\xcd": 600, "\xb1": 600, "\xa6": 600, "\xae": 600, "\u011e": 600, "\u0130": 600, "\u2211": 600, "\xc8": 600, "\u0155": 600, "\u014d": 600, "\u0179": 600, "\u017d": 600, "\u2265": 600, "\xd0": 600, "\xc7": 600, "\u013c": 600, "\u0165": 600, "\u0119": 600, "\u0172": 600, "\xc1": 600, "\xc4": 600, "\xe8": 600, "\u017a": 600, "\u012f": 600, "\xd3": 600, "\xf3": 600, "\u0101": 600, "\u015b": 600, "\xef": 600, "\xd4": 600, "\xd9": 600, "\u2206": 600, "\xfe": 600, "\xb2": 600, "\xd6": 600, "\xb5": 600, "\xec": 600, "\u0151": 600, "\u0118": 600, "\u0111": 600, "\xbe": 600, "\u015e": 600, "\u013e": 600, "\u0136": 600, "\u0139": 600, "\u2122": 600, "\u0117": 600, "\xcc": 600, "\u012a": 600, "\u013d": 600, "\xbd": 600, "\u2264": 600, "\xf4": 600, "\xf1": 600, "\u0170": 600, "\xc9": 600, "\u0113": 600, "\u011f": 600, "\xbc": 600, "\u0160": 600, "\u0218": 600, "\u0150": 600, "\xb0": 600, "\xf2": 600, "\u010c": 600, "\xf9": 600, "\u221a": 600, "\u010e": 600, "\u0157": 600, "\xd1": 600, "\xf5": 600, "\u0156": 600, "\u013b": 600, "\xc3": 600, "\u0104": 600, "\xc5": 600, "\xd5": 600, "\u017c": 600, "\u011a": 600, "\u012e": 600, "\u0137": 600, "\u2212": 600, "\xce": 600, "\u0148": 600, "\u0163": 600, "\xac": 600, "\xf6": 600, "\xfc": 600, "\u2260": 600, "\u0123": 600, "\xf0": 600, "\u017e": 600, "\u0146": 600, "\xb9": 600, "\u012b": 600, "\u20ac": 600, }, ), # Generated from Courier-BoldOblique.afm # Copyright (c) 1989, 1990, 1991, 1993, 1997 Adobe Systems Incorporated. All Rights Reserved. "Courier-BoldOblique": FontDescriptor( name="Courier-BoldOblique", family="Courier", weight="Bold", ascent=629, descent=-157, cap_height=562, x_height=439, italic_angle=-12, flags=97, bbox=(-57.0, -250.0, 869.0, 801.0), character_widths={ " ": 600, "!": 600, '"': 600, "#": 600, "$": 600, "%": 600, "&": 600, "\u2019": 600, "(": 600, ")": 600, "*": 600, "+": 600, ",": 600, "-": 600, ".": 600, "/": 600, "0": 600, "1": 600, "2": 600, "3": 600, "4": 600, "5": 600, "6": 600, "7": 600, "8": 600, "9": 600, ":": 600, ";": 600, "<": 600, "=": 600, ">": 600, "?": 600, "@": 600, "A": 600, "B": 600, "C": 600, "D": 600, "E": 600, "F": 600, "G": 600, "H": 600, "I": 600, "J": 600, "K": 600, "L": 600, "M": 600, "N": 600, "O": 600, "P": 600, "Q": 600, "R": 600, "S": 600, "T": 600, "U": 600, "V": 600, "W": 600, "X": 600, "Y": 600, "Z": 600, "[": 600, "\\": 600, "]": 600, "^": 600, "_": 600, "\u2018": 600, "a": 600, "b": 600, "c": 600, "d": 600, "e": 600, "f": 600, "g": 600, "h": 600, "i": 600, "j": 600, "k": 600, "l": 600, "m": 600, "n": 600, "o": 600, "p": 600, "q": 600, "r": 600, "s": 600, "t": 600, "u": 600, "v": 600, "w": 600, "x": 600, "y": 600, "z": 600, "{": 600, "|": 600, "}": 600, "~": 600, "\xa1": 600, "\xa2": 600, "\xa3": 600, "\u2044": 600, "\xa5": 600, "\u0192": 600, "\xa7": 600, "\xa4": 600, "'": 600, "\u201c": 600, "\xab": 600, "\u2039": 600, "\u203a": 600, "\ufb01": 600, "\ufb02": 600, "\u2013": 600, "\u2020": 600, "\u2021": 600, "\xb7": 600, "\xb6": 600, "\u2022": 600, "\u201a": 600, "\u201e": 600, "\u201d": 600, "\xbb": 600, "\u2026": 600, "\u2030": 600, "\xbf": 600, "`": 600, "\xb4": 600, "\u02c6": 600, "\u02dc": 600, "\xaf": 600, "\u02d8": 600, "\u02d9": 600, "\xa8": 600, "\u02da": 600, "\xb8": 600, "\u02dd": 600, "\u02db": 600, "\u02c7": 600, "\u2014": 600, "\xc6": 600, "\xaa": 600, "\u0141": 600, "\xd8": 600, "\u0152": 600, "\xba": 600, "\xe6": 600, "\u0131": 600, "\u0142": 600, "\xf8": 600, "\u0153": 600, "\xdf": 600, "\xcf": 600, "\xe9": 600, "\u0103": 600, "\u0171": 600, "\u011b": 600, "\u0178": 600, "\xf7": 600, "\xdd": 600, "\xc2": 600, "\xe1": 600, "\xdb": 600, "\xfd": 600, "\u0219": 600, "\xea": 600, "\u016e": 600, "\xdc": 600, "\u0105": 600, "\xda": 600, "\u0173": 600, "\xcb": 600, "\u0110": 600, "\uf6c3": 600, "\xa9": 600, "\u0112": 600, "\u010d": 600, "\xe5": 600, "\u0145": 600, "\u013a": 600, "\xe0": 600, "\u0162": 600, "\u0106": 600, "\xe3": 600, "\u0116": 600, "\u0161": 600, "\u015f": 600, "\xed": 600, "\u25ca": 600, "\u0158": 600, "\u0122": 600, "\xfb": 600, "\xe2": 600, "\u0100": 600, "\u0159": 600, "\xe7": 600, "\u017b": 600, "\xde": 600, "\u014c": 600, "\u0154": 600, "\u015a": 600, "\u010f": 600, "\u016a": 600, "\u016f": 600, "\xb3": 600, "\xd2": 600, "\xc0": 600, "\u0102": 600, "\xd7": 600, "\xfa": 600, "\u0164": 600, "\u2202": 600, "\xff": 600, "\u0143": 600, "\xee": 600, "\xca": 600, "\xe4": 600, "\xeb": 600, "\u0107": 600, "\u0144": 600, "\u016b": 600, "\u0147": 600, "\xcd": 600, "\xb1": 600, "\xa6": 600, "\xae": 600, "\u011e": 600, "\u0130": 600, "\u2211": 600, "\xc8": 600, "\u0155": 600, "\u014d": 600, "\u0179": 600, "\u017d": 600, "\u2265": 600, "\xd0": 600, "\xc7": 600, "\u013c": 600, "\u0165": 600, "\u0119": 600, "\u0172": 600, "\xc1": 600, "\xc4": 600, "\xe8": 600, "\u017a": 600, "\u012f": 600, "\xd3": 600, "\xf3": 600, "\u0101": 600, "\u015b": 600, "\xef": 600, "\xd4": 600, "\xd9": 600, "\u2206": 600, "\xfe": 600, "\xb2": 600, "\xd6": 600, "\xb5": 600, "\xec": 600, "\u0151": 600, "\u0118": 600, "\u0111": 600, "\xbe": 600, "\u015e": 600, "\u013e": 600, "\u0136": 600, "\u0139": 600, "\u2122": 600, "\u0117": 600, "\xcc": 600, "\u012a": 600, "\u013d": 600, "\xbd": 600, "\u2264": 600, "\xf4": 600, "\xf1": 600, "\u0170": 600, "\xc9": 600, "\u0113": 600, "\u011f": 600, "\xbc": 600, "\u0160": 600, "\u0218": 600, "\u0150": 600, "\xb0": 600, "\xf2": 600, "\u010c": 600, "\xf9": 600, "\u221a": 600, "\u010e": 600, "\u0157": 600, "\xd1": 600, "\xf5": 600, "\u0156": 600, "\u013b": 600, "\xc3": 600, "\u0104": 600, "\xc5": 600, "\xd5": 600, "\u017c": 600, "\u011a": 600, "\u012e": 600, "\u0137": 600, "\u2212": 600, "\xce": 600, "\u0148": 600, "\u0163": 600, "\xac": 600, "\xf6": 600, "\xfc": 600, "\u2260": 600, "\u0123": 600, "\xf0": 600, "\u017e": 600, "\u0146": 600, "\xb9": 600, "\u012b": 600, "\u20ac": 600, }, ), # Generated from Courier-Oblique.afm # Copyright (c) 1989, 1990, 1991, 1992, 1993, 1997 Adobe Systems Incorporated. All Rights # Reserved. "Courier-Oblique": FontDescriptor( name="Courier-Oblique", family="Courier", weight="Medium", ascent=629, descent=-157, cap_height=562, x_height=426, italic_angle=-12, flags=97, bbox=(-27.0, -250.0, 849.0, 805.0), character_widths={ " ": 600, "!": 600, '"': 600, "#": 600, "$": 600, "%": 600, "&": 600, "\u2019": 600, "(": 600, ")": 600, "*": 600, "+": 600, ",": 600, "-": 600, ".": 600, "/": 600, "0": 600, "1": 600, "2": 600, "3": 600, "4": 600, "5": 600, "6": 600, "7": 600, "8": 600, "9": 600, ":": 600, ";": 600, "<": 600, "=": 600, ">": 600, "?": 600, "@": 600, "A": 600, "B": 600, "C": 600, "D": 600, "E": 600, "F": 600, "G": 600, "H": 600, "I": 600, "J": 600, "K": 600, "L": 600, "M": 600, "N": 600, "O": 600, "P": 600, "Q": 600, "R": 600, "S": 600, "T": 600, "U": 600, "V": 600, "W": 600, "X": 600, "Y": 600, "Z": 600, "[": 600, "\\": 600, "]": 600, "^": 600, "_": 600, "\u2018": 600, "a": 600, "b": 600, "c": 600, "d": 600, "e": 600, "f": 600, "g": 600, "h": 600, "i": 600, "j": 600, "k": 600, "l": 600, "m": 600, "n": 600, "o": 600, "p": 600, "q": 600, "r": 600, "s": 600, "t": 600, "u": 600, "v": 600, "w": 600, "x": 600, "y": 600, "z": 600, "{": 600, "|": 600, "}": 600, "~": 600, "\xa1": 600, "\xa2": 600, "\xa3": 600, "\u2044": 600, "\xa5": 600, "\u0192": 600, "\xa7": 600, "\xa4": 600, "'": 600, "\u201c": 600, "\xab": 600, "\u2039": 600, "\u203a": 600, "\ufb01": 600, "\ufb02": 600, "\u2013": 600, "\u2020": 600, "\u2021": 600, "\xb7": 600, "\xb6": 600, "\u2022": 600, "\u201a": 600, "\u201e": 600, "\u201d": 600, "\xbb": 600, "\u2026": 600, "\u2030": 600, "\xbf": 600, "`": 600, "\xb4": 600, "\u02c6": 600, "\u02dc": 600, "\xaf": 600, "\u02d8": 600, "\u02d9": 600, "\xa8": 600, "\u02da": 600, "\xb8": 600, "\u02dd": 600, "\u02db": 600, "\u02c7": 600, "\u2014": 600, "\xc6": 600, "\xaa": 600, "\u0141": 600, "\xd8": 600, "\u0152": 600, "\xba": 600, "\xe6": 600, "\u0131": 600, "\u0142": 600, "\xf8": 600, "\u0153": 600, "\xdf": 600, "\xcf": 600, "\xe9": 600, "\u0103": 600, "\u0171": 600, "\u011b": 600, "\u0178": 600, "\xf7": 600, "\xdd": 600, "\xc2": 600, "\xe1": 600, "\xdb": 600, "\xfd": 600, "\u0219": 600, "\xea": 600, "\u016e": 600, "\xdc": 600, "\u0105": 600, "\xda": 600, "\u0173": 600, "\xcb": 600, "\u0110": 600, "\uf6c3": 600, "\xa9": 600, "\u0112": 600, "\u010d": 600, "\xe5": 600, "\u0145": 600, "\u013a": 600, "\xe0": 600, "\u0162": 600, "\u0106": 600, "\xe3": 600, "\u0116": 600, "\u0161": 600, "\u015f": 600, "\xed": 600, "\u25ca": 600, "\u0158": 600, "\u0122": 600, "\xfb": 600, "\xe2": 600, "\u0100": 600, "\u0159": 600, "\xe7": 600, "\u017b": 600, "\xde": 600, "\u014c": 600, "\u0154": 600, "\u015a": 600, "\u010f": 600, "\u016a": 600, "\u016f": 600, "\xb3": 600, "\xd2": 600, "\xc0": 600, "\u0102": 600, "\xd7": 600, "\xfa": 600, "\u0164": 600, "\u2202": 600, "\xff": 600, "\u0143": 600, "\xee": 600, "\xca": 600, "\xe4": 600, "\xeb": 600, "\u0107": 600, "\u0144": 600, "\u016b": 600, "\u0147": 600, "\xcd": 600, "\xb1": 600, "\xa6": 600, "\xae": 600, "\u011e": 600, "\u0130": 600, "\u2211": 600, "\xc8": 600, "\u0155": 600, "\u014d": 600, "\u0179": 600, "\u017d": 600, "\u2265": 600, "\xd0": 600, "\xc7": 600, "\u013c": 600, "\u0165": 600, "\u0119": 600, "\u0172": 600, "\xc1": 600, "\xc4": 600, "\xe8": 600, "\u017a": 600, "\u012f": 600, "\xd3": 600, "\xf3": 600, "\u0101": 600, "\u015b": 600, "\xef": 600, "\xd4": 600, "\xd9": 600, "\u2206": 600, "\xfe": 600, "\xb2": 600, "\xd6": 600, "\xb5": 600, "\xec": 600, "\u0151": 600, "\u0118": 600, "\u0111": 600, "\xbe": 600, "\u015e": 600, "\u013e": 600, "\u0136": 600, "\u0139": 600, "\u2122": 600, "\u0117": 600, "\xcc": 600, "\u012a": 600, "\u013d": 600, "\xbd": 600, "\u2264": 600, "\xf4": 600, "\xf1": 600, "\u0170": 600, "\xc9": 600, "\u0113": 600, "\u011f": 600, "\xbc": 600, "\u0160": 600, "\u0218": 600, "\u0150": 600, "\xb0": 600, "\xf2": 600, "\u010c": 600, "\xf9": 600, "\u221a": 600, "\u010e": 600, "\u0157": 600, "\xd1": 600, "\xf5": 600, "\u0156": 600, "\u013b": 600, "\xc3": 600, "\u0104": 600, "\xc5": 600, "\xd5": 600, "\u017c": 600, "\u011a": 600, "\u012e": 600, "\u0137": 600, "\u2212": 600, "\xce": 600, "\u0148": 600, "\u0163": 600, "\xac": 600, "\xf6": 600, "\xfc": 600, "\u2260": 600, "\u0123": 600, "\xf0": 600, "\u017e": 600, "\u0146": 600, "\xb9": 600, "\u012b": 600, "\u20ac": 600, }, ), # Generated from Helvetica.afm # Copyright (c) 1985, 1987, 1989, 1990, 1997 Adobe Systems Incorporated. All Rights Reserved. # Helvetica is a trademark of Linotype-Hell AG and/or its subsidiaries. "Helvetica": FontDescriptor( name="Helvetica", family="Helvetica", weight="Medium", ascent=718, descent=-207, cap_height=718, x_height=523, italic_angle=0, flags=32, bbox=(-166.0, -225.0, 1000.0, 931.0), character_widths={ " ": 278, "!": 278, '"': 355, "#": 556, "$": 556, "%": 889, "&": 667, "\u2019": 222, "(": 333, ")": 333, "*": 389, "+": 584, ",": 278, "-": 333, ".": 278, "/": 278, "0": 556, "1": 556, "2": 556, "3": 556, "4": 556, "5": 556, "6": 556, "7": 556, "8": 556, "9": 556, ":": 278, ";": 278, "<": 584, "=": 584, ">": 584, "?": 556, "@": 1015, "A": 667, "B": 667, "C": 722, "D": 722, "E": 667, "F": 611, "G": 778, "H": 722, "I": 278, "J": 500, "K": 667, "L": 556, "M": 833, "N": 722, "O": 778, "P": 667, "Q": 778, "R": 722, "S": 667, "T": 611, "U": 722, "V": 667, "W": 944, "X": 667, "Y": 667, "Z": 611, "[": 278, "\\": 278, "]": 278, "^": 469, "_": 556, "\u2018": 222, "a": 556, "b": 556, "c": 500, "d": 556, "e": 556, "f": 278, "g": 556, "h": 556, "i": 222, "j": 222, "k": 500, "l": 222, "m": 833, "n": 556, "o": 556, "p": 556, "q": 556, "r": 333, "s": 500, "t": 278, "u": 556, "v": 500, "w": 722, "x": 500, "y": 500, "z": 500, "{": 334, "|": 260, "}": 334, "~": 584, "\xa1": 333, "\xa2": 556, "\xa3": 556, "\u2044": 167, "\xa5": 556, "\u0192": 556, "\xa7": 556, "\xa4": 556, "'": 191, "\u201c": 333, "\xab": 556, "\u2039": 333, "\u203a": 333, "\ufb01": 500, "\ufb02": 500, "\u2013": 556, "\u2020": 556, "\u2021": 556, "\xb7": 278, "\xb6": 537, "\u2022": 350, "\u201a": 222, "\u201e": 333, "\u201d": 333, "\xbb": 556, "\u2026": 1000, "\u2030": 1000, "\xbf": 611, "`": 333, "\xb4": 333, "\u02c6": 333, "\u02dc": 333, "\xaf": 333, "\u02d8": 333, "\u02d9": 333, "\xa8": 333, "\u02da": 333, "\xb8": 333, "\u02dd": 333, "\u02db": 333, "\u02c7": 333, "\u2014": 1000, "\xc6": 1000, "\xaa": 370, "\u0141": 556, "\xd8": 778, "\u0152": 1000, "\xba": 365, "\xe6": 889, "\u0131": 278, "\u0142": 222, "\xf8": 611, "\u0153": 944, "\xdf": 611, "\xcf": 278, "\xe9": 556, "\u0103": 556, "\u0171": 556, "\u011b": 556, "\u0178": 667, "\xf7": 584, "\xdd": 667, "\xc2": 667, "\xe1": 556, "\xdb": 722, "\xfd": 500, "\u0219": 500, "\xea": 556, "\u016e": 722, "\xdc": 722, "\u0105": 556, "\xda": 722, "\u0173": 556, "\xcb": 667, "\u0110": 722, "\uf6c3": 250, "\xa9": 737, "\u0112": 667, "\u010d": 500, "\xe5": 556, "\u0145": 722, "\u013a": 222, "\xe0": 556, "\u0162": 611, "\u0106": 722, "\xe3": 556, "\u0116": 667, "\u0161": 500, "\u015f": 500, "\xed": 278, "\u25ca": 471, "\u0158": 722, "\u0122": 778, "\xfb": 556, "\xe2": 556, "\u0100": 667, "\u0159": 333, "\xe7": 500, "\u017b": 611, "\xde": 667, "\u014c": 778, "\u0154": 722, "\u015a": 667, "\u010f": 643, "\u016a": 722, "\u016f": 556, "\xb3": 333, "\xd2": 778, "\xc0": 667, "\u0102": 667, "\xd7": 584, "\xfa": 556, "\u0164": 611, "\u2202": 476, "\xff": 500, "\u0143": 722, "\xee": 278, "\xca": 667, "\xe4": 556, "\xeb": 556, "\u0107": 500, "\u0144": 556, "\u016b": 556, "\u0147": 722, "\xcd": 278, "\xb1": 584, "\xa6": 260, "\xae": 737, "\u011e": 778, "\u0130": 278, "\u2211": 600, "\xc8": 667, "\u0155": 333, "\u014d": 556, "\u0179": 611, "\u017d": 611, "\u2265": 549, "\xd0": 722, "\xc7": 722, "\u013c": 222, "\u0165": 317, "\u0119": 556, "\u0172": 722, "\xc1": 667, "\xc4": 667, "\xe8": 556, "\u017a": 500, "\u012f": 222, "\xd3": 778, "\xf3": 556, "\u0101": 556, "\u015b": 500, "\xef": 278, "\xd4": 778, "\xd9": 722, "\u2206": 612, "\xfe": 556, "\xb2": 333, "\xd6": 778, "\xb5": 556, "\xec": 278, "\u0151": 556, "\u0118": 667, "\u0111": 556, "\xbe": 834, "\u015e": 667, "\u013e": 299, "\u0136": 667, "\u0139": 556, "\u2122": 1000, "\u0117": 556, "\xcc": 278, "\u012a": 278, "\u013d": 556, "\xbd": 834, "\u2264": 549, "\xf4": 556, "\xf1": 556, "\u0170": 722, "\xc9": 667, "\u0113": 556, "\u011f": 556, "\xbc": 834, "\u0160": 667, "\u0218": 667, "\u0150": 778, "\xb0": 400, "\xf2": 556, "\u010c": 722, "\xf9": 556, "\u221a": 453, "\u010e": 722, "\u0157": 333, "\xd1": 722, "\xf5": 556, "\u0156": 722, "\u013b": 556, "\xc3": 667, "\u0104": 667, "\xc5": 667, "\xd5": 778, "\u017c": 500, "\u011a": 667, "\u012e": 278, "\u0137": 500, "\u2212": 584, "\xce": 278, "\u0148": 556, "\u0163": 278, "\xac": 584, "\xf6": 556, "\xfc": 556, "\u2260": 549, "\u0123": 556, "\xf0": 556, "\u017e": 500, "\u0146": 556, "\xb9": 333, "\u012b": 278, "\u20ac": 556, }, ), # Generated from Helvetica-Bold.afm # Copyright (c) 1985, 1987, 1989, 1990, 1997 Adobe Systems Incorporated. All Rights Reserved. # Helvetica is a trademark of Linotype-Hell AG and/or its subsidiaries. "Helvetica-Bold": FontDescriptor( name="Helvetica-Bold", family="Helvetica", weight="Bold", ascent=718, descent=-207, cap_height=718, x_height=532, italic_angle=0, flags=32, bbox=(-170.0, -228.0, 1003.0, 962.0), character_widths={ " ": 278, "!": 333, '"': 474, "#": 556, "$": 556, "%": 889, "&": 722, "\u2019": 278, "(": 333, ")": 333, "*": 389, "+": 584, ",": 278, "-": 333, ".": 278, "/": 278, "0": 556, "1": 556, "2": 556, "3": 556, "4": 556, "5": 556, "6": 556, "7": 556, "8": 556, "9": 556, ":": 333, ";": 333, "<": 584, "=": 584, ">": 584, "?": 611, "@": 975, "A": 722, "B": 722, "C": 722, "D": 722, "E": 667, "F": 611, "G": 778, "H": 722, "I": 278, "J": 556, "K": 722, "L": 611, "M": 833, "N": 722, "O": 778, "P": 667, "Q": 778, "R": 722, "S": 667, "T": 611, "U": 722, "V": 667, "W": 944, "X": 667, "Y": 667, "Z": 611, "[": 333, "\\": 278, "]": 333, "^": 584, "_": 556, "\u2018": 278, "a": 556, "b": 611, "c": 556, "d": 611, "e": 556, "f": 333, "g": 611, "h": 611, "i": 278, "j": 278, "k": 556, "l": 278, "m": 889, "n": 611, "o": 611, "p": 611, "q": 611, "r": 389, "s": 556, "t": 333, "u": 611, "v": 556, "w": 778, "x": 556, "y": 556, "z": 500, "{": 389, "|": 280, "}": 389, "~": 584, "\xa1": 333, "\xa2": 556, "\xa3": 556, "\u2044": 167, "\xa5": 556, "\u0192": 556, "\xa7": 556, "\xa4": 556, "'": 238, "\u201c": 500, "\xab": 556, "\u2039": 333, "\u203a": 333, "\ufb01": 611, "\ufb02": 611, "\u2013": 556, "\u2020": 556, "\u2021": 556, "\xb7": 278, "\xb6": 556, "\u2022": 350, "\u201a": 278, "\u201e": 500, "\u201d": 500, "\xbb": 556, "\u2026": 1000, "\u2030": 1000, "\xbf": 611, "`": 333, "\xb4": 333, "\u02c6": 333, "\u02dc": 333, "\xaf": 333, "\u02d8": 333, "\u02d9": 333, "\xa8": 333, "\u02da": 333, "\xb8": 333, "\u02dd": 333, "\u02db": 333, "\u02c7": 333, "\u2014": 1000, "\xc6": 1000, "\xaa": 370, "\u0141": 611, "\xd8": 778, "\u0152": 1000, "\xba": 365, "\xe6": 889, "\u0131": 278, "\u0142": 278, "\xf8": 611, "\u0153": 944, "\xdf": 611, "\xcf": 278, "\xe9": 556, "\u0103": 556, "\u0171": 611, "\u011b": 556, "\u0178": 667, "\xf7": 584, "\xdd": 667, "\xc2": 722, "\xe1": 556, "\xdb": 722, "\xfd": 556, "\u0219": 556, "\xea": 556, "\u016e": 722, "\xdc": 722, "\u0105": 556, "\xda": 722, "\u0173": 611, "\xcb": 667, "\u0110": 722, "\uf6c3": 250, "\xa9": 737, "\u0112": 667, "\u010d": 556, "\xe5": 556, "\u0145": 722, "\u013a": 278, "\xe0": 556, "\u0162": 611, "\u0106": 722, "\xe3": 556, "\u0116": 667, "\u0161": 556, "\u015f": 556, "\xed": 278, "\u25ca": 494, "\u0158": 722, "\u0122": 778, "\xfb": 611, "\xe2": 556, "\u0100": 722, "\u0159": 389, "\xe7": 556, "\u017b": 611, "\xde": 667, "\u014c": 778, "\u0154": 722, "\u015a": 667, "\u010f": 743, "\u016a": 722, "\u016f": 611, "\xb3": 333, "\xd2": 778, "\xc0": 722, "\u0102": 722, "\xd7": 584, "\xfa": 611, "\u0164": 611, "\u2202": 494, "\xff": 556, "\u0143": 722, "\xee": 278, "\xca": 667, "\xe4": 556, "\xeb": 556, "\u0107": 556, "\u0144": 611, "\u016b": 611, "\u0147": 722, "\xcd": 278, "\xb1": 584, "\xa6": 280, "\xae": 737, "\u011e": 778, "\u0130": 278, "\u2211": 600, "\xc8": 667, "\u0155": 389, "\u014d": 611, "\u0179": 611, "\u017d": 611, "\u2265": 549, "\xd0": 722, "\xc7": 722, "\u013c": 278, "\u0165": 389, "\u0119": 556, "\u0172": 722, "\xc1": 722, "\xc4": 722, "\xe8": 556, "\u017a": 500, "\u012f": 278, "\xd3": 778, "\xf3": 611, "\u0101": 556, "\u015b": 556, "\xef": 278, "\xd4": 778, "\xd9": 722, "\u2206": 612, "\xfe": 611, "\xb2": 333, "\xd6": 778, "\xb5": 611, "\xec": 278, "\u0151": 611, "\u0118": 667, "\u0111": 611, "\xbe": 834, "\u015e": 667, "\u013e": 400, "\u0136": 722, "\u0139": 611, "\u2122": 1000, "\u0117": 556, "\xcc": 278, "\u012a": 278, "\u013d": 611, "\xbd": 834, "\u2264": 549, "\xf4": 611, "\xf1": 611, "\u0170": 722, "\xc9": 667, "\u0113": 556, "\u011f": 611, "\xbc": 834, "\u0160": 667, "\u0218": 667, "\u0150": 778, "\xb0": 400, "\xf2": 611, "\u010c": 722, "\xf9": 611, "\u221a": 549, "\u010e": 722, "\u0157": 389, "\xd1": 722, "\xf5": 611, "\u0156": 722, "\u013b": 611, "\xc3": 722, "\u0104": 722, "\xc5": 722, "\xd5": 778, "\u017c": 500, "\u011a": 667, "\u012e": 278, "\u0137": 556, "\u2212": 584, "\xce": 278, "\u0148": 611, "\u0163": 333, "\xac": 584, "\xf6": 611, "\xfc": 611, "\u2260": 549, "\u0123": 611, "\xf0": 611, "\u017e": 500, "\u0146": 611, "\xb9": 333, "\u012b": 278, "\u20ac": 556, }, ), # Generated from Helvetica-BoldOblique.afm # Copyright (c) 1985, 1987, 1989, 1990, 1997 Adobe Systems Incorporated. All Rights Reserved. # Helvetica is a trademark of Linotype-Hell AG and/or its subsidiaries. "Helvetica-BoldOblique": FontDescriptor( name="Helvetica-BoldOblique", family="Helvetica", weight="Bold", ascent=718, descent=-207, cap_height=718, x_height=532, italic_angle=-12, flags=96, bbox=(-174.0, -228.0, 1114.0, 962.0), character_widths={ " ": 278, "!": 333, '"': 474, "#": 556, "$": 556, "%": 889, "&": 722, "\u2019": 278, "(": 333, ")": 333, "*": 389, "+": 584, ",": 278, "-": 333, ".": 278, "/": 278, "0": 556, "1": 556, "2": 556, "3": 556, "4": 556, "5": 556, "6": 556, "7": 556, "8": 556, "9": 556, ":": 333, ";": 333, "<": 584, "=": 584, ">": 584, "?": 611, "@": 975, "A": 722, "B": 722, "C": 722, "D": 722, "E": 667, "F": 611, "G": 778, "H": 722, "I": 278, "J": 556, "K": 722, "L": 611, "M": 833, "N": 722, "O": 778, "P": 667, "Q": 778, "R": 722, "S": 667, "T": 611, "U": 722, "V": 667, "W": 944, "X": 667, "Y": 667, "Z": 611, "[": 333, "\\": 278, "]": 333, "^": 584, "_": 556, "\u2018": 278, "a": 556, "b": 611, "c": 556, "d": 611, "e": 556, "f": 333, "g": 611, "h": 611, "i": 278, "j": 278, "k": 556, "l": 278, "m": 889, "n": 611, "o": 611, "p": 611, "q": 611, "r": 389, "s": 556, "t": 333, "u": 611, "v": 556, "w": 778, "x": 556, "y": 556, "z": 500, "{": 389, "|": 280, "}": 389, "~": 584, "\xa1": 333, "\xa2": 556, "\xa3": 556, "\u2044": 167, "\xa5": 556, "\u0192": 556, "\xa7": 556, "\xa4": 556, "'": 238, "\u201c": 500, "\xab": 556, "\u2039": 333, "\u203a": 333, "\ufb01": 611, "\ufb02": 611, "\u2013": 556, "\u2020": 556, "\u2021": 556, "\xb7": 278, "\xb6": 556, "\u2022": 350, "\u201a": 278, "\u201e": 500, "\u201d": 500, "\xbb": 556, "\u2026": 1000, "\u2030": 1000, "\xbf": 611, "`": 333, "\xb4": 333, "\u02c6": 333, "\u02dc": 333, "\xaf": 333, "\u02d8": 333, "\u02d9": 333, "\xa8": 333, "\u02da": 333, "\xb8": 333, "\u02dd": 333, "\u02db": 333, "\u02c7": 333, "\u2014": 1000, "\xc6": 1000, "\xaa": 370, "\u0141": 611, "\xd8": 778, "\u0152": 1000, "\xba": 365, "\xe6": 889, "\u0131": 278, "\u0142": 278, "\xf8": 611, "\u0153": 944, "\xdf": 611, "\xcf": 278, "\xe9": 556, "\u0103": 556, "\u0171": 611, "\u011b": 556, "\u0178": 667, "\xf7": 584, "\xdd": 667, "\xc2": 722, "\xe1": 556, "\xdb": 722, "\xfd": 556, "\u0219": 556, "\xea": 556, "\u016e": 722, "\xdc": 722, "\u0105": 556, "\xda": 722, "\u0173": 611, "\xcb": 667, "\u0110": 722, "\uf6c3": 250, "\xa9": 737, "\u0112": 667, "\u010d": 556, "\xe5": 556, "\u0145": 722, "\u013a": 278, "\xe0": 556, "\u0162": 611, "\u0106": 722, "\xe3": 556, "\u0116": 667, "\u0161": 556, "\u015f": 556, "\xed": 278, "\u25ca": 494, "\u0158": 722, "\u0122": 778, "\xfb": 611, "\xe2": 556, "\u0100": 722, "\u0159": 389, "\xe7": 556, "\u017b": 611, "\xde": 667, "\u014c": 778, "\u0154": 722, "\u015a": 667, "\u010f": 743, "\u016a": 722, "\u016f": 611, "\xb3": 333, "\xd2": 778, "\xc0": 722, "\u0102": 722, "\xd7": 584, "\xfa": 611, "\u0164": 611, "\u2202": 494, "\xff": 556, "\u0143": 722, "\xee": 278, "\xca": 667, "\xe4": 556, "\xeb": 556, "\u0107": 556, "\u0144": 611, "\u016b": 611, "\u0147": 722, "\xcd": 278, "\xb1": 584, "\xa6": 280, "\xae": 737, "\u011e": 778, "\u0130": 278, "\u2211": 600, "\xc8": 667, "\u0155": 389, "\u014d": 611, "\u0179": 611, "\u017d": 611, "\u2265": 549, "\xd0": 722, "\xc7": 722, "\u013c": 278, "\u0165": 389, "\u0119": 556, "\u0172": 722, "\xc1": 722, "\xc4": 722, "\xe8": 556, "\u017a": 500, "\u012f": 278, "\xd3": 778, "\xf3": 611, "\u0101": 556, "\u015b": 556, "\xef": 278, "\xd4": 778, "\xd9": 722, "\u2206": 612, "\xfe": 611, "\xb2": 333, "\xd6": 778, "\xb5": 611, "\xec": 278, "\u0151": 611, "\u0118": 667, "\u0111": 611, "\xbe": 834, "\u015e": 667, "\u013e": 400, "\u0136": 722, "\u0139": 611, "\u2122": 1000, "\u0117": 556, "\xcc": 278, "\u012a": 278, "\u013d": 611, "\xbd": 834, "\u2264": 549, "\xf4": 611, "\xf1": 611, "\u0170": 722, "\xc9": 667, "\u0113": 556, "\u011f": 611, "\xbc": 834, "\u0160": 667, "\u0218": 667, "\u0150": 778, "\xb0": 400, "\xf2": 611, "\u010c": 722, "\xf9": 611, "\u221a": 549, "\u010e": 722, "\u0157": 389, "\xd1": 722, "\xf5": 611, "\u0156": 722, "\u013b": 611, "\xc3": 722, "\u0104": 722, "\xc5": 722, "\xd5": 778, "\u017c": 500, "\u011a": 667, "\u012e": 278, "\u0137": 556, "\u2212": 584, "\xce": 278, "\u0148": 611, "\u0163": 333, "\xac": 584, "\xf6": 611, "\xfc": 611, "\u2260": 549, "\u0123": 611, "\xf0": 611, "\u017e": 500, "\u0146": 611, "\xb9": 333, "\u012b": 278, "\u20ac": 556, }, ), # Generated from Helvetica-Oblique.afm # Copyright (c) 1985, 1987, 1989, 1990, 1997 Adobe Systems Incorporated. All Rights Reserved. # Helvetica is a trademark of Linotype-Hell AG and/or its subsidiaries. "Helvetica-Oblique": FontDescriptor( name="Helvetica-Oblique", family="Helvetica", weight="Medium", ascent=718, descent=-207, cap_height=718, x_height=523, italic_angle=-12, flags=96, bbox=(-170.0, -225.0, 1116.0, 931.0), character_widths={ " ": 278, "!": 278, '"': 355, "#": 556, "$": 556, "%": 889, "&": 667, "\u2019": 222, "(": 333, ")": 333, "*": 389, "+": 584, ",": 278, "-": 333, ".": 278, "/": 278, "0": 556, "1": 556, "2": 556, "3": 556, "4": 556, "5": 556, "6": 556, "7": 556, "8": 556, "9": 556, ":": 278, ";": 278, "<": 584, "=": 584, ">": 584, "?": 556, "@": 1015, "A": 667, "B": 667, "C": 722, "D": 722, "E": 667, "F": 611, "G": 778, "H": 722, "I": 278, "J": 500, "K": 667, "L": 556, "M": 833, "N": 722, "O": 778, "P": 667, "Q": 778, "R": 722, "S": 667, "T": 611, "U": 722, "V": 667, "W": 944, "X": 667, "Y": 667, "Z": 611, "[": 278, "\\": 278, "]": 278, "^": 469, "_": 556, "\u2018": 222, "a": 556, "b": 556, "c": 500, "d": 556, "e": 556, "f": 278, "g": 556, "h": 556, "i": 222, "j": 222, "k": 500, "l": 222, "m": 833, "n": 556, "o": 556, "p": 556, "q": 556, "r": 333, "s": 500, "t": 278, "u": 556, "v": 500, "w": 722, "x": 500, "y": 500, "z": 500, "{": 334, "|": 260, "}": 334, "~": 584, "\xa1": 333, "\xa2": 556, "\xa3": 556, "\u2044": 167, "\xa5": 556, "\u0192": 556, "\xa7": 556, "\xa4": 556, "'": 191, "\u201c": 333, "\xab": 556, "\u2039": 333, "\u203a": 333, "\ufb01": 500, "\ufb02": 500, "\u2013": 556, "\u2020": 556, "\u2021": 556, "\xb7": 278, "\xb6": 537, "\u2022": 350, "\u201a": 222, "\u201e": 333, "\u201d": 333, "\xbb": 556, "\u2026": 1000, "\u2030": 1000, "\xbf": 611, "`": 333, "\xb4": 333, "\u02c6": 333, "\u02dc": 333, "\xaf": 333, "\u02d8": 333, "\u02d9": 333, "\xa8": 333, "\u02da": 333, "\xb8": 333, "\u02dd": 333, "\u02db": 333, "\u02c7": 333, "\u2014": 1000, "\xc6": 1000, "\xaa": 370, "\u0141": 556, "\xd8": 778, "\u0152": 1000, "\xba": 365, "\xe6": 889, "\u0131": 278, "\u0142": 222, "\xf8": 611, "\u0153": 944, "\xdf": 611, "\xcf": 278, "\xe9": 556, "\u0103": 556, "\u0171": 556, "\u011b": 556, "\u0178": 667, "\xf7": 584, "\xdd": 667, "\xc2": 667, "\xe1": 556, "\xdb": 722, "\xfd": 500, "\u0219": 500, "\xea": 556, "\u016e": 722, "\xdc": 722, "\u0105": 556, "\xda": 722, "\u0173": 556, "\xcb": 667, "\u0110": 722, "\uf6c3": 250, "\xa9": 737, "\u0112": 667, "\u010d": 500, "\xe5": 556, "\u0145": 722, "\u013a": 222, "\xe0": 556, "\u0162": 611, "\u0106": 722, "\xe3": 556, "\u0116": 667, "\u0161": 500, "\u015f": 500, "\xed": 278, "\u25ca": 471, "\u0158": 722, "\u0122": 778, "\xfb": 556, "\xe2": 556, "\u0100": 667, "\u0159": 333, "\xe7": 500, "\u017b": 611, "\xde": 667, "\u014c": 778, "\u0154": 722, "\u015a": 667, "\u010f": 643, "\u016a": 722, "\u016f": 556, "\xb3": 333, "\xd2": 778, "\xc0": 667, "\u0102": 667, "\xd7": 584, "\xfa": 556, "\u0164": 611, "\u2202": 476, "\xff": 500, "\u0143": 722, "\xee": 278, "\xca": 667, "\xe4": 556, "\xeb": 556, "\u0107": 500, "\u0144": 556, "\u016b": 556, "\u0147": 722, "\xcd": 278, "\xb1": 584, "\xa6": 260, "\xae": 737, "\u011e": 778, "\u0130": 278, "\u2211": 600, "\xc8": 667, "\u0155": 333, "\u014d": 556, "\u0179": 611, "\u017d": 611, "\u2265": 549, "\xd0": 722, "\xc7": 722, "\u013c": 222, "\u0165": 317, "\u0119": 556, "\u0172": 722, "\xc1": 667, "\xc4": 667, "\xe8": 556, "\u017a": 500, "\u012f": 222, "\xd3": 778, "\xf3": 556, "\u0101": 556, "\u015b": 500, "\xef": 278, "\xd4": 778, "\xd9": 722, "\u2206": 612, "\xfe": 556, "\xb2": 333, "\xd6": 778, "\xb5": 556, "\xec": 278, "\u0151": 556, "\u0118": 667, "\u0111": 556, "\xbe": 834, "\u015e": 667, "\u013e": 299, "\u0136": 667, "\u0139": 556, "\u2122": 1000, "\u0117": 556, "\xcc": 278, "\u012a": 278, "\u013d": 556, "\xbd": 834, "\u2264": 549, "\xf4": 556, "\xf1": 556, "\u0170": 722, "\xc9": 667, "\u0113": 556, "\u011f": 556, "\xbc": 834, "\u0160": 667, "\u0218": 667, "\u0150": 778, "\xb0": 400, "\xf2": 556, "\u010c": 722, "\xf9": 556, "\u221a": 453, "\u010e": 722, "\u0157": 333, "\xd1": 722, "\xf5": 556, "\u0156": 722, "\u013b": 556, "\xc3": 667, "\u0104": 667, "\xc5": 667, "\xd5": 778, "\u017c": 500, "\u011a": 667, "\u012e": 278, "\u0137": 500, "\u2212": 584, "\xce": 278, "\u0148": 556, "\u0163": 278, "\xac": 584, "\xf6": 556, "\xfc": 556, "\u2260": 549, "\u0123": 556, "\xf0": 556, "\u017e": 500, "\u0146": 556, "\xb9": 333, "\u012b": 278, "\u20ac": 556, }, ), # Generated from Symbol.afm # Copyright (c) 1985, 1987, 1989, 1990, 1997 Adobe Systems Incorporated. All rights reserved. "Symbol": FontDescriptor( name="Symbol", family="Symbol", weight="Medium", ascent=0.0, descent=0.0, cap_height=0.0, x_height=0.0, italic_angle=0, flags=4, bbox=(-180.0, -293.0, 1090.0, 1010.0), character_widths={ " ": 250, "!": 333, "\u2200": 713, "#": 500, "\u2203": 549, "%": 833, "&": 778, "\u220b": 439, "(": 333, ")": 333, "\u2217": 500, "+": 549, ",": 250, "\u2212": 549, ".": 250, "/": 278, "0": 500, "1": 500, "2": 500, "3": 500, "4": 500, "5": 500, "6": 500, "7": 500, "8": 500, "9": 500, ":": 278, ";": 278, "<": 549, "=": 549, ">": 549, "?": 444, "\u2245": 549, "\u0391": 722, "\u0392": 667, "\u03a7": 722, "\u2206": 612, "\u0395": 611, "\u03a6": 763, "\u0393": 603, "\u0397": 722, "\u0399": 333, "\u03d1": 631, "\u039a": 722, "\u039b": 686, "\u039c": 889, "\u039d": 722, "\u039f": 722, "\u03a0": 768, "\u0398": 741, "\u03a1": 556, "\u03a3": 592, "\u03a4": 611, "\u03a5": 690, "\u03c2": 439, "\u2126": 768, "\u039e": 645, "\u03a8": 795, "\u0396": 611, "[": 333, "\u2234": 863, "]": 333, "\u22a5": 658, "_": 500, "\uf8e5": 500, "\u03b1": 631, "\u03b2": 549, "\u03c7": 549, "\u03b4": 494, "\u03b5": 439, "\u03c6": 521, "\u03b3": 411, "\u03b7": 603, "\u03b9": 329, "\u03d5": 603, "\u03ba": 549, "\u03bb": 549, "\xb5": 576, "\u03bd": 521, "\u03bf": 549, "\u03c0": 549, "\u03b8": 521, "\u03c1": 549, "\u03c3": 603, "\u03c4": 439, "\u03c5": 576, "\u03d6": 713, "\u03c9": 686, "\u03be": 493, "\u03c8": 686, "\u03b6": 494, "{": 480, "|": 200, "}": 480, "\u223c": 549, "\u20ac": 750, "\u03d2": 620, "\u2032": 247, "\u2264": 549, "\u2044": 167, "\u221e": 713, "\u0192": 500, "\u2663": 753, "\u2666": 753, "\u2665": 753, "\u2660": 753, "\u2194": 1042, "\u2190": 987, "\u2191": 603, "\u2192": 987, "\u2193": 603, "\xb0": 400, "\xb1": 549, "\u2033": 411, "\u2265": 549, "\xd7": 549, "\u221d": 713, "\u2202": 494, "\u2022": 460, "\xf7": 549, "\u2260": 549, "\u2261": 549, "\u2248": 549, "\u2026": 1000, "\uf8e6": 603, "\uf8e7": 1000, "\u21b5": 658, "\u2135": 823, "\u2111": 686, "\u211c": 795, "\u2118": 987, "\u2297": 768, "\u2295": 768, "\u2205": 823, "\u2229": 768, "\u222a": 768, "\u2283": 713, "\u2287": 713, "\u2284": 713, "\u2282": 713, "\u2286": 713, "\u2208": 713, "\u2209": 713, "\u2220": 768, "\u2207": 713, "\uf6da": 790, "\uf6d9": 790, "\uf6db": 890, "\u220f": 823, "\u221a": 549, "\u22c5": 250, "\xac": 713, "\u2227": 603, "\u2228": 603, "\u21d4": 1042, "\u21d0": 987, "\u21d1": 603, "\u21d2": 987, "\u21d3": 603, "\u25ca": 494, "\u2329": 329, "\uf8e8": 790, "\uf8e9": 790, "\uf8ea": 786, "\u2211": 713, "\uf8eb": 384, "\uf8ec": 384, "\uf8ed": 384, "\uf8ee": 384, "\uf8ef": 384, "\uf8f0": 384, "\uf8f1": 494, "\uf8f2": 494, "\uf8f3": 494, "\uf8f4": 494, "\u232a": 329, "\u222b": 274, "\u2320": 686, "\uf8f5": 686, "\u2321": 686, "\uf8f6": 384, "\uf8f7": 384, "\uf8f8": 384, "\uf8f9": 384, "\uf8fa": 384, "\uf8fb": 384, "\uf8fc": 494, "\uf8fd": 494, "\uf8fe": 494, "\uf8ff": 790, }, ), # Generated from Times-Bold.afm # Copyright (c) 1985, 1987, 1989, 1990, 1993, 1997 Adobe Systems Incorporated. All Rights # Reserved. Times is a trademark of Linotype-Hell AG and/or its subsidiaries. "Times-Bold": FontDescriptor( name="Times-Bold", family="Times", weight="Bold", ascent=683, descent=-217, cap_height=676, x_height=461, italic_angle=0, flags=34, bbox=(-168.0, -218.0, 1000.0, 935.0), character_widths={ " ": 250, "!": 333, '"': 555, "#": 500, "$": 500, "%": 1000, "&": 833, "\u2019": 333, "(": 333, ")": 333, "*": 500, "+": 570, ",": 250, "-": 333, ".": 250, "/": 278, "0": 500, "1": 500, "2": 500, "3": 500, "4": 500, "5": 500, "6": 500, "7": 500, "8": 500, "9": 500, ":": 333, ";": 333, "<": 570, "=": 570, ">": 570, "?": 500, "@": 930, "A": 722, "B": 667, "C": 722, "D": 722, "E": 667, "F": 611, "G": 778, "H": 778, "I": 389, "J": 500, "K": 778, "L": 667, "M": 944, "N": 722, "O": 778, "P": 611, "Q": 778, "R": 722, "S": 556, "T": 667, "U": 722, "V": 722, "W": 1000, "X": 722, "Y": 722, "Z": 667, "[": 333, "\\": 278, "]": 333, "^": 581, "_": 500, "\u2018": 333, "a": 500, "b": 556, "c": 444, "d": 556, "e": 444, "f": 333, "g": 500, "h": 556, "i": 278, "j": 333, "k": 556, "l": 278, "m": 833, "n": 556, "o": 500, "p": 556, "q": 556, "r": 444, "s": 389, "t": 333, "u": 556, "v": 500, "w": 722, "x": 500, "y": 500, "z": 444, "{": 394, "|": 220, "}": 394, "~": 520, "\xa1": 333, "\xa2": 500, "\xa3": 500, "\u2044": 167, "\xa5": 500, "\u0192": 500, "\xa7": 500, "\xa4": 500, "'": 278, "\u201c": 500, "\xab": 500, "\u2039": 333, "\u203a": 333, "\ufb01": 556, "\ufb02": 556, "\u2013": 500, "\u2020": 500, "\u2021": 500, "\xb7": 250, "\xb6": 540, "\u2022": 350, "\u201a": 333, "\u201e": 500, "\u201d": 500, "\xbb": 500, "\u2026": 1000, "\u2030": 1000, "\xbf": 500, "`": 333, "\xb4": 333, "\u02c6": 333, "\u02dc": 333, "\xaf": 333, "\u02d8": 333, "\u02d9": 333, "\xa8": 333, "\u02da": 333, "\xb8": 333, "\u02dd": 333, "\u02db": 333, "\u02c7": 333, "\u2014": 1000, "\xc6": 1000, "\xaa": 300, "\u0141": 667, "\xd8": 778, "\u0152": 1000, "\xba": 330, "\xe6": 722, "\u0131": 278, "\u0142": 278, "\xf8": 500, "\u0153": 722, "\xdf": 556, "\xcf": 389, "\xe9": 444, "\u0103": 500, "\u0171": 556, "\u011b": 444, "\u0178": 722, "\xf7": 570, "\xdd": 722, "\xc2": 722, "\xe1": 500, "\xdb": 722, "\xfd": 500, "\u0219": 389, "\xea": 444, "\u016e": 722, "\xdc": 722, "\u0105": 500, "\xda": 722, "\u0173": 556, "\xcb": 667, "\u0110": 722, "\uf6c3": 250, "\xa9": 747, "\u0112": 667, "\u010d": 444, "\xe5": 500, "\u0145": 722, "\u013a": 278, "\xe0": 500, "\u0162": 667, "\u0106": 722, "\xe3": 500, "\u0116": 667, "\u0161": 389, "\u015f": 389, "\xed": 278, "\u25ca": 494, "\u0158": 722, "\u0122": 778, "\xfb": 556, "\xe2": 500, "\u0100": 722, "\u0159": 444, "\xe7": 444, "\u017b": 667, "\xde": 611, "\u014c": 778, "\u0154": 722, "\u015a": 556, "\u010f": 672, "\u016a": 722, "\u016f": 556, "\xb3": 300, "\xd2": 778, "\xc0": 722, "\u0102": 722, "\xd7": 570, "\xfa": 556, "\u0164": 667, "\u2202": 494, "\xff": 500, "\u0143": 722, "\xee": 278, "\xca": 667, "\xe4": 500, "\xeb": 444, "\u0107": 444, "\u0144": 556, "\u016b": 556, "\u0147": 722, "\xcd": 389, "\xb1": 570, "\xa6": 220, "\xae": 747, "\u011e": 778, "\u0130": 389, "\u2211": 600, "\xc8": 667, "\u0155": 444, "\u014d": 500, "\u0179": 667, "\u017d": 667, "\u2265": 549, "\xd0": 722, "\xc7": 722, "\u013c": 278, "\u0165": 416, "\u0119": 444, "\u0172": 722, "\xc1": 722, "\xc4": 722, "\xe8": 444, "\u017a": 444, "\u012f": 278, "\xd3": 778, "\xf3": 500, "\u0101": 500, "\u015b": 389, "\xef": 278, "\xd4": 778, "\xd9": 722, "\u2206": 612, "\xfe": 556, "\xb2": 300, "\xd6": 778, "\xb5": 556, "\xec": 278, "\u0151": 500, "\u0118": 667, "\u0111": 556, "\xbe": 750, "\u015e": 556, "\u013e": 394, "\u0136": 778, "\u0139": 667, "\u2122": 1000, "\u0117": 444, "\xcc": 389, "\u012a": 389, "\u013d": 667, "\xbd": 750, "\u2264": 549, "\xf4": 500, "\xf1": 556, "\u0170": 722, "\xc9": 667, "\u0113": 444, "\u011f": 500, "\xbc": 750, "\u0160": 556, "\u0218": 556, "\u0150": 778, "\xb0": 400, "\xf2": 500, "\u010c": 722, "\xf9": 556, "\u221a": 549, "\u010e": 722, "\u0157": 444, "\xd1": 722, "\xf5": 500, "\u0156": 722, "\u013b": 667, "\xc3": 722, "\u0104": 722, "\xc5": 722, "\xd5": 778, "\u017c": 444, "\u011a": 667, "\u012e": 389, "\u0137": 556, "\u2212": 570, "\xce": 389, "\u0148": 556, "\u0163": 333, "\xac": 570, "\xf6": 500, "\xfc": 556, "\u2260": 549, "\u0123": 500, "\xf0": 500, "\u017e": 444, "\u0146": 556, "\xb9": 300, "\u012b": 278, "\u20ac": 500, }, ), # Generated from Times-BoldItalic.afm # Copyright (c) 1985, 1987, 1989, 1990, 1993, 1997 Adobe Systems Incorporated. All Rights # Reserved. Times is a trademark of Linotype-Hell AG and/or its subsidiaries. "Times-BoldItalic": FontDescriptor( name="Times-BoldItalic", family="Times", weight="Bold", ascent=683, descent=-217, cap_height=669, x_height=462, italic_angle=-15, flags=98, bbox=(-200.0, -218.0, 996.0, 921.0), character_widths={ " ": 250, "!": 389, '"': 555, "#": 500, "$": 500, "%": 833, "&": 778, "\u2019": 333, "(": 333, ")": 333, "*": 500, "+": 570, ",": 250, "-": 333, ".": 250, "/": 278, "0": 500, "1": 500, "2": 500, "3": 500, "4": 500, "5": 500, "6": 500, "7": 500, "8": 500, "9": 500, ":": 333, ";": 333, "<": 570, "=": 570, ">": 570, "?": 500, "@": 832, "A": 667, "B": 667, "C": 667, "D": 722, "E": 667, "F": 667, "G": 722, "H": 778, "I": 389, "J": 500, "K": 667, "L": 611, "M": 889, "N": 722, "O": 722, "P": 611, "Q": 722, "R": 667, "S": 556, "T": 611, "U": 722, "V": 667, "W": 889, "X": 667, "Y": 611, "Z": 611, "[": 333, "\\": 278, "]": 333, "^": 570, "_": 500, "\u2018": 333, "a": 500, "b": 500, "c": 444, "d": 500, "e": 444, "f": 333, "g": 500, "h": 556, "i": 278, "j": 278, "k": 500, "l": 278, "m": 778, "n": 556, "o": 500, "p": 500, "q": 500, "r": 389, "s": 389, "t": 278, "u": 556, "v": 444, "w": 667, "x": 500, "y": 444, "z": 389, "{": 348, "|": 220, "}": 348, "~": 570, "\xa1": 389, "\xa2": 500, "\xa3": 500, "\u2044": 167, "\xa5": 500, "\u0192": 500, "\xa7": 500, "\xa4": 500, "'": 278, "\u201c": 500, "\xab": 500, "\u2039": 333, "\u203a": 333, "\ufb01": 556, "\ufb02": 556, "\u2013": 500, "\u2020": 500, "\u2021": 500, "\xb7": 250, "\xb6": 500, "\u2022": 350, "\u201a": 333, "\u201e": 500, "\u201d": 500, "\xbb": 500, "\u2026": 1000, "\u2030": 1000, "\xbf": 500, "`": 333, "\xb4": 333, "\u02c6": 333, "\u02dc": 333, "\xaf": 333, "\u02d8": 333, "\u02d9": 333, "\xa8": 333, "\u02da": 333, "\xb8": 333, "\u02dd": 333, "\u02db": 333, "\u02c7": 333, "\u2014": 1000, "\xc6": 944, "\xaa": 266, "\u0141": 611, "\xd8": 722, "\u0152": 944, "\xba": 300, "\xe6": 722, "\u0131": 278, "\u0142": 278, "\xf8": 500, "\u0153": 722, "\xdf": 500, "\xcf": 389, "\xe9": 444, "\u0103": 500, "\u0171": 556, "\u011b": 444, "\u0178": 611, "\xf7": 570, "\xdd": 611, "\xc2": 667, "\xe1": 500, "\xdb": 722, "\xfd": 444, "\u0219": 389, "\xea": 444, "\u016e": 722, "\xdc": 722, "\u0105": 500, "\xda": 722, "\u0173": 556, "\xcb": 667, "\u0110": 722, "\uf6c3": 250, "\xa9": 747, "\u0112": 667, "\u010d": 444, "\xe5": 500, "\u0145": 722, "\u013a": 278, "\xe0": 500, "\u0162": 611, "\u0106": 667, "\xe3": 500, "\u0116": 667, "\u0161": 389, "\u015f": 389, "\xed": 278, "\u25ca": 494, "\u0158": 667, "\u0122": 722, "\xfb": 556, "\xe2": 500, "\u0100": 667, "\u0159": 389, "\xe7": 444, "\u017b": 611, "\xde": 611, "\u014c": 722, "\u0154": 667, "\u015a": 556, "\u010f": 608, "\u016a": 722, "\u016f": 556, "\xb3": 300, "\xd2": 722, "\xc0": 667, "\u0102": 667, "\xd7": 570, "\xfa": 556, "\u0164": 611, "\u2202": 494, "\xff": 444, "\u0143": 722, "\xee": 278, "\xca": 667, "\xe4": 500, "\xeb": 444, "\u0107": 444, "\u0144": 556, "\u016b": 556, "\u0147": 722, "\xcd": 389, "\xb1": 570, "\xa6": 220, "\xae": 747, "\u011e": 722, "\u0130": 389, "\u2211": 600, "\xc8": 667, "\u0155": 389, "\u014d": 500, "\u0179": 611, "\u017d": 611, "\u2265": 549, "\xd0": 722, "\xc7": 667, "\u013c": 278, "\u0165": 366, "\u0119": 444, "\u0172": 722, "\xc1": 667, "\xc4": 667, "\xe8": 444, "\u017a": 389, "\u012f": 278, "\xd3": 722, "\xf3": 500, "\u0101": 500, "\u015b": 389, "\xef": 278, "\xd4": 722, "\xd9": 722, "\u2206": 612, "\xfe": 500, "\xb2": 300, "\xd6": 722, "\xb5": 576, "\xec": 278, "\u0151": 500, "\u0118": 667, "\u0111": 500, "\xbe": 750, "\u015e": 556, "\u013e": 382, "\u0136": 667, "\u0139": 611, "\u2122": 1000, "\u0117": 444, "\xcc": 389, "\u012a": 389, "\u013d": 611, "\xbd": 750, "\u2264": 549, "\xf4": 500, "\xf1": 556, "\u0170": 722, "\xc9": 667, "\u0113": 444, "\u011f": 500, "\xbc": 750, "\u0160": 556, "\u0218": 556, "\u0150": 722, "\xb0": 400, "\xf2": 500, "\u010c": 667, "\xf9": 556, "\u221a": 549, "\u010e": 722, "\u0157": 389, "\xd1": 722, "\xf5": 500, "\u0156": 667, "\u013b": 611, "\xc3": 667, "\u0104": 667, "\xc5": 667, "\xd5": 722, "\u017c": 389, "\u011a": 667, "\u012e": 389, "\u0137": 500, "\u2212": 606, "\xce": 389, "\u0148": 556, "\u0163": 278, "\xac": 606, "\xf6": 500, "\xfc": 556, "\u2260": 549, "\u0123": 500, "\xf0": 500, "\u017e": 389, "\u0146": 556, "\xb9": 300, "\u012b": 278, "\u20ac": 500, }, ), # Generated from Times-Italic.afm # Copyright (c) 1985, 1987, 1989, 1990, 1993, 1997 Adobe Systems Incorporated. All Rights # Reserved. Times is a trademark of Linotype-Hell AG and/or its subsidiaries. "Times-Italic": FontDescriptor( name="Times-Italic", family="Times", weight="Medium", ascent=683, descent=-217, cap_height=653, x_height=441, italic_angle=-15.5, flags=98, bbox=(-169.0, -217.0, 1010.0, 883.0), character_widths={ " ": 250, "!": 333, '"': 420, "#": 500, "$": 500, "%": 833, "&": 778, "\u2019": 333, "(": 333, ")": 333, "*": 500, "+": 675, ",": 250, "-": 333, ".": 250, "/": 278, "0": 500, "1": 500, "2": 500, "3": 500, "4": 500, "5": 500, "6": 500, "7": 500, "8": 500, "9": 500, ":": 333, ";": 333, "<": 675, "=": 675, ">": 675, "?": 500, "@": 920, "A": 611, "B": 611, "C": 667, "D": 722, "E": 611, "F": 611, "G": 722, "H": 722, "I": 333, "J": 444, "K": 667, "L": 556, "M": 833, "N": 667, "O": 722, "P": 611, "Q": 722, "R": 611, "S": 500, "T": 556, "U": 722, "V": 611, "W": 833, "X": 611, "Y": 556, "Z": 556, "[": 389, "\\": 278, "]": 389, "^": 422, "_": 500, "\u2018": 333, "a": 500, "b": 500, "c": 444, "d": 500, "e": 444, "f": 278, "g": 500, "h": 500, "i": 278, "j": 278, "k": 444, "l": 278, "m": 722, "n": 500, "o": 500, "p": 500, "q": 500, "r": 389, "s": 389, "t": 278, "u": 500, "v": 444, "w": 667, "x": 444, "y": 444, "z": 389, "{": 400, "|": 275, "}": 400, "~": 541, "\xa1": 389, "\xa2": 500, "\xa3": 500, "\u2044": 167, "\xa5": 500, "\u0192": 500, "\xa7": 500, "\xa4": 500, "'": 214, "\u201c": 556, "\xab": 500, "\u2039": 333, "\u203a": 333, "\ufb01": 500, "\ufb02": 500, "\u2013": 500, "\u2020": 500, "\u2021": 500, "\xb7": 250, "\xb6": 523, "\u2022": 350, "\u201a": 333, "\u201e": 556, "\u201d": 556, "\xbb": 500, "\u2026": 889, "\u2030": 1000, "\xbf": 500, "`": 333, "\xb4": 333, "\u02c6": 333, "\u02dc": 333, "\xaf": 333, "\u02d8": 333, "\u02d9": 333, "\xa8": 333, "\u02da": 333, "\xb8": 333, "\u02dd": 333, "\u02db": 333, "\u02c7": 333, "\u2014": 889, "\xc6": 889, "\xaa": 276, "\u0141": 556, "\xd8": 722, "\u0152": 944, "\xba": 310, "\xe6": 667, "\u0131": 278, "\u0142": 278, "\xf8": 500, "\u0153": 667, "\xdf": 500, "\xcf": 333, "\xe9": 444, "\u0103": 500, "\u0171": 500, "\u011b": 444, "\u0178": 556, "\xf7": 675, "\xdd": 556, "\xc2": 611, "\xe1": 500, "\xdb": 722, "\xfd": 444, "\u0219": 389, "\xea": 444, "\u016e": 722, "\xdc": 722, "\u0105": 500, "\xda": 722, "\u0173": 500, "\xcb": 611, "\u0110": 722, "\uf6c3": 250, "\xa9": 760, "\u0112": 611, "\u010d": 444, "\xe5": 500, "\u0145": 667, "\u013a": 278, "\xe0": 500, "\u0162": 556, "\u0106": 667, "\xe3": 500, "\u0116": 611, "\u0161": 389, "\u015f": 389, "\xed": 278, "\u25ca": 471, "\u0158": 611, "\u0122": 722, "\xfb": 500, "\xe2": 500, "\u0100": 611, "\u0159": 389, "\xe7": 444, "\u017b": 556, "\xde": 611, "\u014c": 722, "\u0154": 611, "\u015a": 500, "\u010f": 544, "\u016a": 722, "\u016f": 500, "\xb3": 300, "\xd2": 722, "\xc0": 611, "\u0102": 611, "\xd7": 675, "\xfa": 500, "\u0164": 556, "\u2202": 476, "\xff": 444, "\u0143": 667, "\xee": 278, "\xca": 611, "\xe4": 500, "\xeb": 444, "\u0107": 444, "\u0144": 500, "\u016b": 500, "\u0147": 667, "\xcd": 333, "\xb1": 675, "\xa6": 275, "\xae": 760, "\u011e": 722, "\u0130": 333, "\u2211": 600, "\xc8": 611, "\u0155": 389, "\u014d": 500, "\u0179": 556, "\u017d": 556, "\u2265": 549, "\xd0": 722, "\xc7": 667, "\u013c": 278, "\u0165": 300, "\u0119": 444, "\u0172": 722, "\xc1": 611, "\xc4": 611, "\xe8": 444, "\u017a": 389, "\u012f": 278, "\xd3": 722, "\xf3": 500, "\u0101": 500, "\u015b": 389, "\xef": 278, "\xd4": 722, "\xd9": 722, "\u2206": 612, "\xfe": 500, "\xb2": 300, "\xd6": 722, "\xb5": 500, "\xec": 278, "\u0151": 500, "\u0118": 611, "\u0111": 500, "\xbe": 750, "\u015e": 500, "\u013e": 300, "\u0136": 667, "\u0139": 556, "\u2122": 980, "\u0117": 444, "\xcc": 333, "\u012a": 333, "\u013d": 611, "\xbd": 750, "\u2264": 549, "\xf4": 500, "\xf1": 500, "\u0170": 722, "\xc9": 611, "\u0113": 444, "\u011f": 500, "\xbc": 750, "\u0160": 500, "\u0218": 500, "\u0150": 722, "\xb0": 400, "\xf2": 500, "\u010c": 667, "\xf9": 500, "\u221a": 453, "\u010e": 722, "\u0157": 389, "\xd1": 667, "\xf5": 500, "\u0156": 611, "\u013b": 556, "\xc3": 611, "\u0104": 611, "\xc5": 611, "\xd5": 722, "\u017c": 389, "\u011a": 611, "\u012e": 333, "\u0137": 444, "\u2212": 675, "\xce": 333, "\u0148": 500, "\u0163": 278, "\xac": 675, "\xf6": 500, "\xfc": 500, "\u2260": 549, "\u0123": 500, "\xf0": 500, "\u017e": 389, "\u0146": 500, "\xb9": 300, "\u012b": 278, "\u20ac": 500, }, ), # Generated from Times-Roman.afm # Copyright (c) 1985, 1987, 1989, 1990, 1993, 1997 Adobe Systems Incorporated. All Rights # Reserved. Times is a trademark of Linotype-Hell AG and/or its subsidiaries. "Times-Roman": FontDescriptor( name="Times-Roman", family="Times", weight="Roman", ascent=683, descent=-217, cap_height=662, x_height=450, italic_angle=0, flags=34, bbox=(-168.0, -218.0, 1000.0, 898.0), character_widths={ " ": 250, "!": 333, '"': 408, "#": 500, "$": 500, "%": 833, "&": 778, "\u2019": 333, "(": 333, ")": 333, "*": 500, "+": 564, ",": 250, "-": 333, ".": 250, "/": 278, "0": 500, "1": 500, "2": 500, "3": 500, "4": 500, "5": 500, "6": 500, "7": 500, "8": 500, "9": 500, ":": 278, ";": 278, "<": 564, "=": 564, ">": 564, "?": 444, "@": 921, "A": 722, "B": 667, "C": 667, "D": 722, "E": 611, "F": 556, "G": 722, "H": 722, "I": 333, "J": 389, "K": 722, "L": 611, "M": 889, "N": 722, "O": 722, "P": 556, "Q": 722, "R": 667, "S": 556, "T": 611, "U": 722, "V": 722, "W": 944, "X": 722, "Y": 722, "Z": 611, "[": 333, "\\": 278, "]": 333, "^": 469, "_": 500, "\u2018": 333, "a": 444, "b": 500, "c": 444, "d": 500, "e": 444, "f": 333, "g": 500, "h": 500, "i": 278, "j": 278, "k": 500, "l": 278, "m": 778, "n": 500, "o": 500, "p": 500, "q": 500, "r": 333, "s": 389, "t": 278, "u": 500, "v": 500, "w": 722, "x": 500, "y": 500, "z": 444, "{": 480, "|": 200, "}": 480, "~": 541, "\xa1": 333, "\xa2": 500, "\xa3": 500, "\u2044": 167, "\xa5": 500, "\u0192": 500, "\xa7": 500, "\xa4": 500, "'": 180, "\u201c": 444, "\xab": 500, "\u2039": 333, "\u203a": 333, "\ufb01": 556, "\ufb02": 556, "\u2013": 500, "\u2020": 500, "\u2021": 500, "\xb7": 250, "\xb6": 453, "\u2022": 350, "\u201a": 333, "\u201e": 444, "\u201d": 444, "\xbb": 500, "\u2026": 1000, "\u2030": 1000, "\xbf": 444, "`": 333, "\xb4": 333, "\u02c6": 333, "\u02dc": 333, "\xaf": 333, "\u02d8": 333, "\u02d9": 333, "\xa8": 333, "\u02da": 333, "\xb8": 333, "\u02dd": 333, "\u02db": 333, "\u02c7": 333, "\u2014": 1000, "\xc6": 889, "\xaa": 276, "\u0141": 611, "\xd8": 722, "\u0152": 889, "\xba": 310, "\xe6": 667, "\u0131": 278, "\u0142": 278, "\xf8": 500, "\u0153": 722, "\xdf": 500, "\xcf": 333, "\xe9": 444, "\u0103": 444, "\u0171": 500, "\u011b": 444, "\u0178": 722, "\xf7": 564, "\xdd": 722, "\xc2": 722, "\xe1": 444, "\xdb": 722, "\xfd": 500, "\u0219": 389, "\xea": 444, "\u016e": 722, "\xdc": 722, "\u0105": 444, "\xda": 722, "\u0173": 500, "\xcb": 611, "\u0110": 722, "\uf6c3": 250, "\xa9": 760, "\u0112": 611, "\u010d": 444, "\xe5": 444, "\u0145": 722, "\u013a": 278, "\xe0": 444, "\u0162": 611, "\u0106": 667, "\xe3": 444, "\u0116": 611, "\u0161": 389, "\u015f": 389, "\xed": 278, "\u25ca": 471, "\u0158": 667, "\u0122": 722, "\xfb": 500, "\xe2": 444, "\u0100": 722, "\u0159": 333, "\xe7": 444, "\u017b": 611, "\xde": 556, "\u014c": 722, "\u0154": 667, "\u015a": 556, "\u010f": 588, "\u016a": 722, "\u016f": 500, "\xb3": 300, "\xd2": 722, "\xc0": 722, "\u0102": 722, "\xd7": 564, "\xfa": 500, "\u0164": 611, "\u2202": 476, "\xff": 500, "\u0143": 722, "\xee": 278, "\xca": 611, "\xe4": 444, "\xeb": 444, "\u0107": 444, "\u0144": 500, "\u016b": 500, "\u0147": 722, "\xcd": 333, "\xb1": 564, "\xa6": 200, "\xae": 760, "\u011e": 722, "\u0130": 333, "\u2211": 600, "\xc8": 611, "\u0155": 333, "\u014d": 500, "\u0179": 611, "\u017d": 611, "\u2265": 549, "\xd0": 722, "\xc7": 667, "\u013c": 278, "\u0165": 326, "\u0119": 444, "\u0172": 722, "\xc1": 722, "\xc4": 722, "\xe8": 444, "\u017a": 444, "\u012f": 278, "\xd3": 722, "\xf3": 500, "\u0101": 444, "\u015b": 389, "\xef": 278, "\xd4": 722, "\xd9": 722, "\u2206": 612, "\xfe": 500, "\xb2": 300, "\xd6": 722, "\xb5": 500, "\xec": 278, "\u0151": 500, "\u0118": 611, "\u0111": 500, "\xbe": 750, "\u015e": 556, "\u013e": 344, "\u0136": 722, "\u0139": 611, "\u2122": 980, "\u0117": 444, "\xcc": 333, "\u012a": 333, "\u013d": 611, "\xbd": 750, "\u2264": 549, "\xf4": 500, "\xf1": 500, "\u0170": 722, "\xc9": 611, "\u0113": 444, "\u011f": 500, "\xbc": 750, "\u0160": 556, "\u0218": 556, "\u0150": 722, "\xb0": 400, "\xf2": 500, "\u010c": 667, "\xf9": 500, "\u221a": 453, "\u010e": 722, "\u0157": 333, "\xd1": 722, "\xf5": 500, "\u0156": 667, "\u013b": 611, "\xc3": 722, "\u0104": 722, "\xc5": 722, "\xd5": 722, "\u017c": 444, "\u011a": 611, "\u012e": 333, "\u0137": 500, "\u2212": 564, "\xce": 333, "\u0148": 500, "\u0163": 278, "\xac": 564, "\xf6": 500, "\xfc": 500, "\u2260": 549, "\u0123": 500, "\xf0": 500, "\u017e": 444, "\u0146": 500, "\xb9": 300, "\u012b": 278, "\u20ac": 500, }, ), # Generated from ZapfDingbats.afm # Copyright (c) 1985, 1987, 1988, 1989, 1997 Adobe Systems Incorporated. All Rights Reserved. # ITC Zapf Dingbats is a registered trademark of International Typeface Corporation. "ZapfDingbats": FontDescriptor( name="ZapfDingbats", family="ZapfDingbats", weight="Medium", ascent=0.0, descent=0.0, cap_height=0.0, x_height=0.0, italic_angle=0, flags=4, bbox=(-1.0, -143.0, 981.0, 820.0), character_widths={ " ": 790, "\x01": 974, "\x02": 961, "\xca": 974, "\x03": 980, "\x04": 719, "\x05": 789, "w": 790, "v": 791, "u": 690, "\x0b": 960, "\x0c": 939, "\r": 549, "\x0e": 855, "\x0f": 911, "\x10": 933, "i": 911, "\x11": 945, "\x12": 974, "\x13": 755, "\x14": 846, "\x15": 762, "\x16": 761, "\x17": 571, "\x18": 677, "\x19": 763, "\x1a": 760, "\x1b": 759, "\x1c": 754, "\x06": 494, "\x07": 552, "\x08": 537, "\t": 577, "\n": 692, "\x1d": 786, "\x1e": 788, "\x1f": 788, "!": 793, '"': 794, "#": 816, "$": 823, "%": 789, "&": 841, "'": 823, "(": 833, ")": 816, "*": 831, "+": 923, ",": 744, "-": 723, ".": 749, "/": 790, "0": 792, "1": 695, "2": 776, "3": 768, "4": 792, "5": 759, "6": 707, "7": 708, "8": 682, "9": 701, ":": 826, ";": 815, "<": 789, "=": 789, ">": 707, "?": 687, "@": 696, "A": 689, "B": 786, "C": 787, "D": 713, "E": 791, "F": 785, "G": 791, "H": 873, "I": 761, "J": 762, "\xcb": 762, "K": 759, "\xcc": 759, "L": 892, "M": 892, "N": 788, "O": 784, "Q": 438, "R": 138, "S": 277, "T": 415, "a": 392, "b": 392, "c": 668, "d": 668, "Y": 390, "Z": 390, "]": 317, "^": 317, "[": 276, "\\": 276, "\xcd": 509, "U": 509, "\xce": 410, "V": 410, "W": 234, "X": 234, "_": 334, "`": 334, "e": 732, "f": 544, "g": 544, "h": 910, "j": 667, "k": 760, "l": 760, "p": 776, "o": 595, "n": 694, "m": 626, "x": 788, "y": 788, "z": 788, "{": 788, "|": 788, "}": 788, "~": 788, "\x7f": 788, "\x80": 788, "\x81": 788, "\x82": 788, "\x83": 788, "\x84": 788, "\x85": 788, "\x86": 788, "\x87": 788, "\x88": 788, "\x89": 788, "\x8a": 788, "\x8b": 788, "\x8c": 788, "\x8d": 788, "\x8e": 788, "\x8f": 788, "\x90": 788, "\x91": 788, "\x92": 788, "\x93": 788, "\x94": 788, "\x95": 788, "\x96": 788, "\x97": 788, "\x98": 788, "\x99": 788, "\x9a": 788, "\x9b": 788, "\x9c": 788, "\x9d": 788, "\x9e": 788, "\x9f": 788, "\xa0": 894, "\xa1": 838, "\xa3": 1016, "\xa4": 458, "\xc4": 748, "\xa5": 924, "\xc0": 748, "\xa6": 918, "\xa7": 927, "\xa8": 928, "\xa9": 928, "\xaa": 834, "\xab": 873, "\xac": 828, "\xad": 924, "\xa2": 924, "\xae": 917, "\xaf": 930, "\xb0": 931, "\xb1": 463, "\xb2": 883, "\xb3": 836, "\xc1": 836, "\xb4": 867, "\xc7": 867, "\xb5": 696, "\xc8": 696, "\xb6": 874, "\xc9": 874, "\xb7": 760, "\xb8": 946, "\xc5": 771, "\xb9": 865, "\xc2": 771, "\xc6": 888, "\xba": 967, "\xc3": 888, "\xbb": 831, "\xbc": 873, "\xbd": 927, "\xbe": 970, "\xbf": 918, }, ), } # Add aliases per table H.3 on pp. 1109-1110 of the PDF 1.7 reference CORE_FONT_METRICS["Arial"] = CORE_FONT_METRICS["Helvetica"] CORE_FONT_METRICS["Arial,Italic"] = CORE_FONT_METRICS["Helvetica-Oblique"] CORE_FONT_METRICS["Arial,Bold"] = CORE_FONT_METRICS["Helvetica-Bold"] CORE_FONT_METRICS["Arial,BoldItalic"] = CORE_FONT_METRICS["Helvetica-BoldOblique"] CORE_FONT_METRICS["CourierNew"] = CORE_FONT_METRICS["Courier"] CORE_FONT_METRICS["CourierNew,Italic"] = CORE_FONT_METRICS["Courier-Oblique"] CORE_FONT_METRICS["CourierNew,Bold"] = CORE_FONT_METRICS["Courier-Bold"] CORE_FONT_METRICS["CourierNew,BoldItalic"] = CORE_FONT_METRICS["Courier-BoldOblique"] CORE_FONT_METRICS["TimesNewRoman"] = CORE_FONT_METRICS["Times-Roman"] CORE_FONT_METRICS["TimesNewRoman,Italic"] = CORE_FONT_METRICS["Times-Italic"] CORE_FONT_METRICS["TimesNewRoman,Bold"] = CORE_FONT_METRICS["Times-Bold"] CORE_FONT_METRICS["TimesNewRoman,BoldItalic"] = CORE_FONT_METRICS["Times-BoldItalic"] pypdf-6.1.2/pypdf/_codecs/pdfdoc.py000066400000000000000000000102551507516550200172050ustar00rootroot00000000000000# PDFDocEncoding Character Set: Table D.2 of PDF Reference 1.7 # C.1 Predefined encodings sorted by character name of another PDF reference # Some indices have '\u0000' although they should have something else: # 22: should be '\u0017' _pdfdoc_encoding = [ "\u0000", "\u0001", "\u0002", "\u0003", "\u0004", "\u0005", "\u0006", "\u0007", # 0 - 7 "\u0008", "\u0009", "\u000a", "\u000b", "\u000c", "\u000d", "\u000e", "\u000f", # 8 - 15 "\u0010", "\u0011", "\u0012", "\u0013", "\u0014", "\u0015", "\u0000", "\u0017", # 16 - 23 "\u02d8", "\u02c7", "\u02c6", "\u02d9", "\u02dd", "\u02db", "\u02da", "\u02dc", # 24 - 31 "\u0020", "\u0021", "\u0022", "\u0023", "\u0024", "\u0025", "\u0026", "\u0027", # 32 - 39 "\u0028", "\u0029", "\u002a", "\u002b", "\u002c", "\u002d", "\u002e", "\u002f", # 40 - 47 "\u0030", "\u0031", "\u0032", "\u0033", "\u0034", "\u0035", "\u0036", "\u0037", # 48 - 55 "\u0038", "\u0039", "\u003a", "\u003b", "\u003c", "\u003d", "\u003e", "\u003f", # 56 - 63 "\u0040", "\u0041", "\u0042", "\u0043", "\u0044", "\u0045", "\u0046", "\u0047", # 64 - 71 "\u0048", "\u0049", "\u004a", "\u004b", "\u004c", "\u004d", "\u004e", "\u004f", # 72 - 79 "\u0050", "\u0051", "\u0052", "\u0053", "\u0054", "\u0055", "\u0056", "\u0057", # 80 - 87 "\u0058", "\u0059", "\u005a", "\u005b", "\u005c", "\u005d", "\u005e", "\u005f", # 88 - 95 "\u0060", "\u0061", "\u0062", "\u0063", "\u0064", "\u0065", "\u0066", "\u0067", # 96 - 103 "\u0068", "\u0069", "\u006a", "\u006b", "\u006c", "\u006d", "\u006e", "\u006f", # 104 - 111 "\u0070", "\u0071", "\u0072", "\u0073", "\u0074", "\u0075", "\u0076", "\u0077", # 112 - 119 "\u0078", "\u0079", "\u007a", "\u007b", "\u007c", "\u007d", "\u007e", "\u0000", # 120 - 127 "\u2022", "\u2020", "\u2021", "\u2026", "\u2014", "\u2013", "\u0192", "\u2044", # 128 - 135 "\u2039", "\u203a", "\u2212", "\u2030", "\u201e", "\u201c", "\u201d", "\u2018", # 136 - 143 "\u2019", "\u201a", "\u2122", "\ufb01", "\ufb02", "\u0141", "\u0152", "\u0160", # 144 - 151 "\u0178", "\u017d", "\u0131", "\u0142", "\u0153", "\u0161", "\u017e", "\u0000", # 152 - 159 "\u20ac", "\u00a1", "\u00a2", "\u00a3", "\u00a4", "\u00a5", "\u00a6", "\u00a7", # 160 - 167 "\u00a8", "\u00a9", "\u00aa", "\u00ab", "\u00ac", "\u0000", "\u00ae", "\u00af", # 168 - 175 "\u00b0", "\u00b1", "\u00b2", "\u00b3", "\u00b4", "\u00b5", "\u00b6", "\u00b7", # 176 - 183 "\u00b8", "\u00b9", "\u00ba", "\u00bb", "\u00bc", "\u00bd", "\u00be", "\u00bf", # 184 - 191 "\u00c0", "\u00c1", "\u00c2", "\u00c3", "\u00c4", "\u00c5", "\u00c6", "\u00c7", # 192 - 199 "\u00c8", "\u00c9", "\u00ca", "\u00cb", "\u00cc", "\u00cd", "\u00ce", "\u00cf", # 200 - 207 "\u00d0", "\u00d1", "\u00d2", "\u00d3", "\u00d4", "\u00d5", "\u00d6", "\u00d7", # 208 - 215 "\u00d8", "\u00d9", "\u00da", "\u00db", "\u00dc", "\u00dd", "\u00de", "\u00df", # 216 - 223 "\u00e0", "\u00e1", "\u00e2", "\u00e3", "\u00e4", "\u00e5", "\u00e6", "\u00e7", # 224 - 231 "\u00e8", "\u00e9", "\u00ea", "\u00eb", "\u00ec", "\u00ed", "\u00ee", "\u00ef", # 232 - 239 "\u00f0", "\u00f1", "\u00f2", "\u00f3", "\u00f4", "\u00f5", "\u00f6", "\u00f7", # 240 - 247 "\u00f8", "\u00f9", "\u00fa", "\u00fb", "\u00fc", "\u00fd", "\u00fe", "\u00ff", # 248 - 255 ] assert len(_pdfdoc_encoding) == 256 pypdf-6.1.2/pypdf/_codecs/std.py000066400000000000000000000051061507516550200165370ustar00rootroot00000000000000_std_encoding = [ "\x00", "\x01", "\x02", "\x03", "\x04", "\x05", "\x06", "\x07", "\x08", "\t", "\n", "\x0b", "\x0c", "\r", "\x0e", "\x0f", "\x10", "\x11", "\x12", "\x13", "\x14", "\x15", "\x16", "\x17", "\x18", "\x19", "\x1a", "\x1b", "\x1c", "\x1d", "\x1e", "\x1f", " ", "!", '"', "#", "$", "%", "&", "’", "(", ")", "*", "+", ",", "-", ".", "/", "0", "1", "2", "3", "4", "5", "6", "7", "8", "9", ":", ";", "<", "=", ">", "?", "@", "A", "B", "C", "D", "E", "F", "G", "H", "I", "J", "K", "L", "M", "N", "O", "P", "Q", "R", "S", "T", "U", "V", "W", "X", "Y", "Z", "[", "\\", "]", "^", "_", "â€", "a", "b", "c", "d", "e", "f", "g", "h", "i", "j", "k", "l", "m", "n", "o", "p", "q", "r", "s", "t", "u", "v", "w", "x", "y", "z", "{", "|", "}", "~", "\x7f", "\x80", "\x81", "\x82", "\x83", "\x84", "\x85", "\x86", "\x87", "\x88", "\x89", "\x8a", "\x8b", "\x8c", "\x8d", "\x8e", "\x8f", "\x90", "\x91", "\x92", "\x93", "\x94", "\x95", "\x96", "\x97", "\x98", "\x99", "\x9a", "\x9b", "\x9c", "\x9d", "\x9e", "\x9f", "\xa0", "¡", "¢", "ÂŁ", "â„", "ÂĄ", "Ć’", "§", "¤", "'", "“", "«", "‹", "›", "ď¬", "fl", "°", "–", "†", "‡", "·", "µ", "¶", "•", "‚", "„", "”", "»", "…", "‰", "Âľ", "Âż", "Ă€", "`", "´", "ˆ", "Ëś", "ÂŻ", "Ë", "Ë™", "¨", "É", "Ëš", "¸", "ĂŚ", "Ëť", "Ë›", "ˇ", "—", "Ă‘", "Ă’", "Ă“", "Ă”", "Ă•", "Ă–", "Ă—", "Ă", "Ă™", "Ăš", "Ă›", "Ăś", "Ăť", "Ăž", "Ăź", "Ă ", "Æ", "â", "ÂŞ", "ä", "ĂĄ", "æ", "ç", "Ĺ", "Ă", "Ĺ’", "Âş", "ì", "Ă­", "Ă®", "ĂŻ", "Ă°", "æ", "ò", "Ăł", "Ă´", "ı", "ö", "Ă·", "Ĺ‚", "ø", "Ĺ“", "Ăź", "ĂĽ", "Ă˝", "Ăľ", "Ăż", ] pypdf-6.1.2/pypdf/_codecs/symbol.py000066400000000000000000000072261507516550200172570ustar00rootroot00000000000000# manually generated from https://www.unicode.org/Public/MAPPINGS/VENDORS/ADOBE/symbol.txt _symbol_encoding = [ "\u0000", "\u0001", "\u0002", "\u0003", "\u0004", "\u0005", "\u0006", "\u0007", "\u0008", "\u0009", "\u000A", "\u000B", "\u000C", "\u000D", "\u000E", "\u000F", "\u0010", "\u0011", "\u0012", "\u0013", "\u0014", "\u0015", "\u0016", "\u0017", "\u0018", "\u0019", "\u001A", "\u001B", "\u001C", "\u001D", "\u001E", "\u001F", "\u0020", "\u0021", "\u2200", "\u0023", "\u2203", "\u0025", "\u0026", "\u220B", "\u0028", "\u0029", "\u2217", "\u002B", "\u002C", "\u2212", "\u002E", "\u002F", "\u0030", "\u0031", "\u0032", "\u0033", "\u0034", "\u0035", "\u0036", "\u0037", "\u0038", "\u0039", "\u003A", "\u003B", "\u003C", "\u003D", "\u003E", "\u003F", "\u2245", "\u0391", "\u0392", "\u03A7", "\u0394", "\u0395", "\u03A6", "\u0393", "\u0397", "\u0399", "\u03D1", "\u039A", "\u039B", "\u039C", "\u039D", "\u039F", "\u03A0", "\u0398", "\u03A1", "\u03A3", "\u03A4", "\u03A5", "\u03C2", "\u03A9", "\u039E", "\u03A8", "\u0396", "\u005B", "\u2234", "\u005D", "\u22A5", "\u005F", "\uF8E5", "\u03B1", "\u03B2", "\u03C7", "\u03B4", "\u03B5", "\u03C6", "\u03B3", "\u03B7", "\u03B9", "\u03D5", "\u03BA", "\u03BB", "\u00B5", "\u03BD", "\u03BF", "\u03C0", "\u03B8", "\u03C1", "\u03C3", "\u03C4", "\u03C5", "\u03D6", "\u03C9", "\u03BE", "\u03C8", "\u03B6", "\u007B", "\u007C", "\u007D", "\u223C", "\u007F", "\u0080", "\u0081", "\u0082", "\u0083", "\u0084", "\u0085", "\u0086", "\u0087", "\u0088", "\u0089", "\u008A", "\u008B", "\u008C", "\u008D", "\u008E", "\u008F", "\u0090", "\u0091", "\u0092", "\u0093", "\u0094", "\u0095", "\u0096", "\u0097", "\u0098", "\u0099", "\u009A", "\u009B", "\u009C", "\u009D", "\u009E", "\u009F", "\u20AC", "\u03D2", "\u2032", "\u2264", "\u2044", "\u221E", "\u0192", "\u2663", "\u2666", "\u2665", "\u2660", "\u2194", "\u2190", "\u2191", "\u2192", "\u2193", "\u00B0", "\u00B1", "\u2033", "\u2265", "\u00D7", "\u221D", "\u2202", "\u2022", "\u00F7", "\u2260", "\u2261", "\u2248", "\u2026", "\uF8E6", "\uF8E7", "\u21B5", "\u2135", "\u2111", "\u211C", "\u2118", "\u2297", "\u2295", "\u2205", "\u2229", "\u222A", "\u2283", "\u2287", "\u2284", "\u2282", "\u2286", "\u2208", "\u2209", "\u2220", "\u2207", "\uF6DA", "\uF6D9", "\uF6DB", "\u220F", "\u221A", "\u22C5", "\u00AC", "\u2227", "\u2228", "\u21D4", "\u21D0", "\u21D1", "\u21D2", "\u21D3", "\u25CA", "\u2329", "\uF8E8", "\uF8E9", "\uF8EA", "\u2211", "\uF8EB", "\uF8EC", "\uF8ED", "\uF8EE", "\uF8EF", "\uF8F0", "\uF8F1", "\uF8F2", "\uF8F3", "\uF8F4", "\u00F0", "\u232A", "\u222B", "\u2320", "\uF8F5", "\u2321", "\uF8F6", "\uF8F7", "\uF8F8", "\uF8F9", "\uF8FA", "\uF8FB", "\uF8FC", "\uF8FD", "\uF8FE", "\u00FF", ] assert len(_symbol_encoding) == 256 pypdf-6.1.2/pypdf/_codecs/zapfding.py000066400000000000000000000072361507516550200175550ustar00rootroot00000000000000# manually generated from https://www.unicode.org/Public/MAPPINGS/VENDORS/ADOBE/zdingbat.txt _zapfding_encoding = [ "\u0000", "\u0001", "\u0002", "\u0003", "\u0004", "\u0005", "\u0006", "\u0007", "\u0008", "\u0009", "\u000A", "\u000B", "\u000C", "\u000D", "\u000E", "\u000F", "\u0010", "\u0011", "\u0012", "\u0013", "\u0014", "\u0015", "\u0016", "\u0017", "\u0018", "\u0019", "\u001A", "\u001B", "\u001C", "\u001D", "\u001E", "\u001F", "\u0020", "\u2701", "\u2702", "\u2703", "\u2704", "\u260E", "\u2706", "\u2707", "\u2708", "\u2709", "\u261B", "\u261E", "\u270C", "\u270D", "\u270E", "\u270F", "\u2710", "\u2711", "\u2712", "\u2713", "\u2714", "\u2715", "\u2716", "\u2717", "\u2718", "\u2719", "\u271A", "\u271B", "\u271C", "\u271D", "\u271E", "\u271F", "\u2720", "\u2721", "\u2722", "\u2723", "\u2724", "\u2725", "\u2726", "\u2727", "\u2605", "\u2729", "\u272A", "\u272B", "\u272C", "\u272D", "\u272E", "\u272F", "\u2730", "\u2731", "\u2732", "\u2733", "\u2734", "\u2735", "\u2736", "\u2737", "\u2738", "\u2739", "\u273A", "\u273B", "\u273C", "\u273D", "\u273E", "\u273F", "\u2740", "\u2741", "\u2742", "\u2743", "\u2744", "\u2745", "\u2746", "\u2747", "\u2748", "\u2749", "\u274A", "\u274B", "\u25CF", "\u274D", "\u25A0", "\u274F", "\u2750", "\u2751", "\u2752", "\u25B2", "\u25BC", "\u25C6", "\u2756", "\u25D7", "\u2758", "\u2759", "\u275A", "\u275B", "\u275C", "\u275D", "\u275E", "\u007F", "\uF8D7", "\uF8D8", "\uF8D9", "\uF8DA", "\uF8DB", "\uF8DC", "\uF8DD", "\uF8DE", "\uF8DF", "\uF8E0", "\uF8E1", "\uF8E2", "\uF8E3", "\uF8E4", "\u008E", "\u008F", "\u0090", "\u0091", "\u0092", "\u0093", "\u0094", "\u0095", "\u0096", "\u0097", "\u0098", "\u0099", "\u009A", "\u009B", "\u009C", "\u009D", "\u009E", "\u009F", "\u00A0", "\u2761", "\u2762", "\u2763", "\u2764", "\u2765", "\u2766", "\u2767", "\u2663", "\u2666", "\u2665", "\u2660", "\u2460", "\u2461", "\u2462", "\u2463", "\u2464", "\u2465", "\u2466", "\u2467", "\u2468", "\u2469", "\u2776", "\u2777", "\u2778", "\u2779", "\u277A", "\u277B", "\u277C", "\u277D", "\u277E", "\u277F", "\u2780", "\u2781", "\u2782", "\u2783", "\u2784", "\u2785", "\u2786", "\u2787", "\u2788", "\u2789", "\u278A", "\u278B", "\u278C", "\u278D", "\u278E", "\u278F", "\u2790", "\u2791", "\u2792", "\u2793", "\u2794", "\u2192", "\u2194", "\u2195", "\u2798", "\u2799", "\u279A", "\u279B", "\u279C", "\u279D", "\u279E", "\u279F", "\u27A0", "\u27A1", "\u27A2", "\u27A3", "\u27A4", "\u27A5", "\u27A6", "\u27A7", "\u27A8", "\u27A9", "\u27AA", "\u27AB", "\u27AC", "\u27AD", "\u27AE", "\u27AF", "\u00F0", "\u27B1", "\u27B2", "\u27B3", "\u27B4", "\u27B5", "\u27B6", "\u27B7", "\u27B8", "\u27B9", "\u27BA", "\u27BB", "\u27BC", "\u27BD", "\u27BE", "\u00FF", ] assert len(_zapfding_encoding) == 256 pypdf-6.1.2/pypdf/_crypt_providers/000077500000000000000000000000001507516550200173675ustar00rootroot00000000000000pypdf-6.1.2/pypdf/_crypt_providers/__init__.py000066400000000000000000000057561507516550200215150ustar00rootroot00000000000000# Copyright (c) 2023, exiledkingcc # All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. from pypdf._crypt_providers._base import CryptBase, CryptIdentity try: from pypdf._crypt_providers._cryptography import ( CryptAES, CryptRC4, aes_cbc_decrypt, aes_cbc_encrypt, aes_ecb_decrypt, aes_ecb_encrypt, crypt_provider, rc4_decrypt, rc4_encrypt, ) from pypdf._utils import Version if Version(crypt_provider[1]) <= Version("3.0"): # This is due to the backend parameter being required back then: # https://cryptography.io/en/latest/changelog/#v3-1 raise ImportError("cryptography<=3.0 is not supported") # pragma: no cover except ImportError: try: from pypdf._crypt_providers._pycryptodome import ( # type: ignore CryptAES, CryptRC4, aes_cbc_decrypt, aes_cbc_encrypt, aes_ecb_decrypt, aes_ecb_encrypt, crypt_provider, rc4_decrypt, rc4_encrypt, ) except ImportError: from pypdf._crypt_providers._fallback import ( # type: ignore CryptAES, CryptRC4, aes_cbc_decrypt, aes_cbc_encrypt, aes_ecb_decrypt, aes_ecb_encrypt, crypt_provider, rc4_decrypt, rc4_encrypt, ) __all__ = [ "CryptAES", "CryptBase", "CryptIdentity", "CryptRC4", "aes_cbc_decrypt", "aes_cbc_encrypt", "aes_ecb_decrypt", "aes_ecb_encrypt", "crypt_provider", "rc4_decrypt", "rc4_encrypt", ] pypdf-6.1.2/pypdf/_crypt_providers/_base.py000066400000000000000000000032571507516550200210210ustar00rootroot00000000000000# Copyright (c) 2023, exiledkingcc # All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. class CryptBase: def encrypt(self, data: bytes) -> bytes: # pragma: no cover return data def decrypt(self, data: bytes) -> bytes: # pragma: no cover return data class CryptIdentity(CryptBase): pass pypdf-6.1.2/pypdf/_crypt_providers/_cryptography.py000066400000000000000000000107151507516550200226370ustar00rootroot00000000000000# Copyright (c) 2023, exiledkingcc # All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. import secrets from cryptography import __version__ from cryptography.hazmat.primitives import padding from cryptography.hazmat.primitives.ciphers.algorithms import AES try: # 43.0.0 - https://cryptography.io/en/latest/changelog/#v43-0-0 from cryptography.hazmat.decrepit.ciphers.algorithms import ARC4 except ImportError: from cryptography.hazmat.primitives.ciphers.algorithms import ARC4 from cryptography.hazmat.primitives.ciphers.base import Cipher from cryptography.hazmat.primitives.ciphers.modes import CBC, ECB from pypdf._crypt_providers._base import CryptBase crypt_provider = ("cryptography", __version__) class CryptRC4(CryptBase): def __init__(self, key: bytes) -> None: self.cipher = Cipher(ARC4(key), mode=None) def encrypt(self, data: bytes) -> bytes: encryptor = self.cipher.encryptor() return encryptor.update(data) + encryptor.finalize() def decrypt(self, data: bytes) -> bytes: decryptor = self.cipher.decryptor() return decryptor.update(data) + decryptor.finalize() class CryptAES(CryptBase): def __init__(self, key: bytes) -> None: self.alg = AES(key) def encrypt(self, data: bytes) -> bytes: iv = secrets.token_bytes(16) pad = padding.PKCS7(128).padder() data = pad.update(data) + pad.finalize() cipher = Cipher(self.alg, CBC(iv)) encryptor = cipher.encryptor() return iv + encryptor.update(data) + encryptor.finalize() def decrypt(self, data: bytes) -> bytes: iv = data[:16] data = data[16:] # for empty encrypted data if not data: return data # just for robustness, it does not happen under normal circumstances if len(data) % 16 != 0: pad = padding.PKCS7(128).padder() data = pad.update(data) + pad.finalize() cipher = Cipher(self.alg, CBC(iv)) decryptor = cipher.decryptor() d = decryptor.update(data) + decryptor.finalize() return d[: -d[-1]] def rc4_encrypt(key: bytes, data: bytes) -> bytes: encryptor = Cipher(ARC4(key), mode=None).encryptor() return encryptor.update(data) + encryptor.finalize() def rc4_decrypt(key: bytes, data: bytes) -> bytes: decryptor = Cipher(ARC4(key), mode=None).decryptor() return decryptor.update(data) + decryptor.finalize() def aes_ecb_encrypt(key: bytes, data: bytes) -> bytes: encryptor = Cipher(AES(key), mode=ECB()).encryptor() return encryptor.update(data) + encryptor.finalize() def aes_ecb_decrypt(key: bytes, data: bytes) -> bytes: decryptor = Cipher(AES(key), mode=ECB()).decryptor() return decryptor.update(data) + decryptor.finalize() def aes_cbc_encrypt(key: bytes, iv: bytes, data: bytes) -> bytes: encryptor = Cipher(AES(key), mode=CBC(iv)).encryptor() return encryptor.update(data) + encryptor.finalize() def aes_cbc_decrypt(key: bytes, iv: bytes, data: bytes) -> bytes: decryptor = Cipher(AES(key), mode=CBC(iv)).decryptor() return decryptor.update(data) + decryptor.finalize() pypdf-6.1.2/pypdf/_crypt_providers/_fallback.py000066400000000000000000000064061507516550200216450ustar00rootroot00000000000000# Copyright (c) 2023, exiledkingcc # All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. from pypdf._crypt_providers._base import CryptBase from pypdf.errors import DependencyError _DEPENDENCY_ERROR_STR = "cryptography>=3.1 is required for AES algorithm" crypt_provider = ("local_crypt_fallback", "0.0.0") class CryptRC4(CryptBase): def __init__(self, key: bytes) -> None: self.s = bytearray(range(256)) j = 0 for i in range(256): j = (j + self.s[i] + key[i % len(key)]) % 256 self.s[i], self.s[j] = self.s[j], self.s[i] def encrypt(self, data: bytes) -> bytes: s = bytearray(self.s) out = [0 for _ in range(len(data))] i, j = 0, 0 for k in range(len(data)): i = (i + 1) % 256 j = (j + s[i]) % 256 s[i], s[j] = s[j], s[i] x = s[(s[i] + s[j]) % 256] out[k] = data[k] ^ x return bytes(out) def decrypt(self, data: bytes) -> bytes: return self.encrypt(data) class CryptAES(CryptBase): def __init__(self, key: bytes) -> None: pass def encrypt(self, data: bytes) -> bytes: raise DependencyError(_DEPENDENCY_ERROR_STR) def decrypt(self, data: bytes) -> bytes: raise DependencyError(_DEPENDENCY_ERROR_STR) def rc4_encrypt(key: bytes, data: bytes) -> bytes: return CryptRC4(key).encrypt(data) def rc4_decrypt(key: bytes, data: bytes) -> bytes: return CryptRC4(key).decrypt(data) def aes_ecb_encrypt(key: bytes, data: bytes) -> bytes: raise DependencyError(_DEPENDENCY_ERROR_STR) def aes_ecb_decrypt(key: bytes, data: bytes) -> bytes: raise DependencyError(_DEPENDENCY_ERROR_STR) def aes_cbc_encrypt(key: bytes, iv: bytes, data: bytes) -> bytes: raise DependencyError(_DEPENDENCY_ERROR_STR) def aes_cbc_decrypt(key: bytes, iv: bytes, data: bytes) -> bytes: raise DependencyError(_DEPENDENCY_ERROR_STR) pypdf-6.1.2/pypdf/_crypt_providers/_pycryptodome.py000066400000000000000000000064651507516550200226510ustar00rootroot00000000000000# Copyright (c) 2023, exiledkingcc # All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. import secrets from Crypto import __version__ from Crypto.Cipher import AES, ARC4 from Crypto.Util.Padding import pad from pypdf._crypt_providers._base import CryptBase crypt_provider = ("pycryptodome", __version__) class CryptRC4(CryptBase): def __init__(self, key: bytes) -> None: self.key = key def encrypt(self, data: bytes) -> bytes: return ARC4.ARC4Cipher(self.key).encrypt(data) def decrypt(self, data: bytes) -> bytes: return ARC4.ARC4Cipher(self.key).decrypt(data) class CryptAES(CryptBase): def __init__(self, key: bytes) -> None: self.key = key def encrypt(self, data: bytes) -> bytes: iv = secrets.token_bytes(16) data = pad(data, 16) aes = AES.new(self.key, AES.MODE_CBC, iv) return iv + aes.encrypt(data) def decrypt(self, data: bytes) -> bytes: iv = data[:16] data = data[16:] # for empty encrypted data if not data: return data # just for robustness, it does not happen under normal circumstances if len(data) % 16 != 0: data = pad(data, 16) aes = AES.new(self.key, AES.MODE_CBC, iv) d = aes.decrypt(data) return d[: -d[-1]] def rc4_encrypt(key: bytes, data: bytes) -> bytes: return ARC4.ARC4Cipher(key).encrypt(data) def rc4_decrypt(key: bytes, data: bytes) -> bytes: return ARC4.ARC4Cipher(key).decrypt(data) def aes_ecb_encrypt(key: bytes, data: bytes) -> bytes: return AES.new(key, AES.MODE_ECB).encrypt(data) def aes_ecb_decrypt(key: bytes, data: bytes) -> bytes: return AES.new(key, AES.MODE_ECB).decrypt(data) def aes_cbc_encrypt(key: bytes, iv: bytes, data: bytes) -> bytes: return AES.new(key, AES.MODE_CBC, iv).encrypt(data) def aes_cbc_decrypt(key: bytes, iv: bytes, data: bytes) -> bytes: return AES.new(key, AES.MODE_CBC, iv).decrypt(data) pypdf-6.1.2/pypdf/_doc_common.py000066400000000000000000001462411507516550200166300ustar00rootroot00000000000000# Copyright (c) 2006, Mathieu Fenniak # Copyright (c) 2007, Ashish Kulkarni # Copyright (c) 2024, Pubpub-ZZ # # All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. import struct import zlib from abc import abstractmethod from collections.abc import Generator, Iterable, Iterator, Mapping from datetime import datetime from typing import ( Any, Optional, Union, cast, ) from ._encryption import Encryption from ._page import PageObject, _VirtualList from ._page_labels import index2label as page_index2page_label from ._utils import ( deprecation_with_replacement, logger_warning, parse_iso8824_date, ) from .constants import CatalogAttributes as CA from .constants import CatalogDictionary as CD from .constants import ( CheckboxRadioButtonAttributes, GoToActionArguments, PagesAttributes, UserAccessPermissions, ) from .constants import Core as CO from .constants import DocumentInformationAttributes as DI from .constants import FieldDictionaryAttributes as FA from .constants import PageAttributes as PG from .errors import PdfReadError, PyPdfError from .generic import ( ArrayObject, BooleanObject, ByteStringObject, Destination, DictionaryObject, EncodedStreamObject, Field, Fit, FloatObject, IndirectObject, NameObject, NullObject, NumberObject, PdfObject, TextStringObject, TreeObject, ViewerPreferences, create_string_object, is_null_or_none, ) from .generic._files import EmbeddedFile from .types import OutlineType, PagemodeType from .xmp import XmpInformation def convert_to_int(d: bytes, size: int) -> Union[int, tuple[Any, ...]]: if size > 8: raise PdfReadError("Invalid size in convert_to_int") d = b"\x00\x00\x00\x00\x00\x00\x00\x00" + d d = d[-8:] return struct.unpack(">q", d)[0] class DocumentInformation(DictionaryObject): """ A class representing the basic document metadata provided in a PDF File. This class is accessible through :py:class:`PdfReader.metadata`. All text properties of the document metadata have *two* properties, e.g. author and author_raw. The non-raw property will always return a ``TextStringObject``, making it ideal for a case where the metadata is being displayed. The raw property can sometimes return a ``ByteStringObject``, if pypdf was unable to decode the string's text encoding; this requires additional safety in the caller and therefore is not as commonly accessed. """ def __init__(self) -> None: DictionaryObject.__init__(self) def _get_text(self, key: str) -> Optional[str]: retval = self.get(key, None) if isinstance(retval, TextStringObject): return retval if isinstance(retval, ByteStringObject): return str(retval) return None @property def title(self) -> Optional[str]: """ Read-only property accessing the document's title. Returns a ``TextStringObject`` or ``None`` if the title is not specified. """ return ( self._get_text(DI.TITLE) or self.get(DI.TITLE).get_object() # type: ignore if self.get(DI.TITLE) else None ) @property def title_raw(self) -> Optional[str]: """The "raw" version of title; can return a ``ByteStringObject``.""" return self.get(DI.TITLE) @property def author(self) -> Optional[str]: """ Read-only property accessing the document's author. Returns a ``TextStringObject`` or ``None`` if the author is not specified. """ return self._get_text(DI.AUTHOR) @property def author_raw(self) -> Optional[str]: """The "raw" version of author; can return a ``ByteStringObject``.""" return self.get(DI.AUTHOR) @property def subject(self) -> Optional[str]: """ Read-only property accessing the document's subject. Returns a ``TextStringObject`` or ``None`` if the subject is not specified. """ return self._get_text(DI.SUBJECT) @property def subject_raw(self) -> Optional[str]: """The "raw" version of subject; can return a ``ByteStringObject``.""" return self.get(DI.SUBJECT) @property def creator(self) -> Optional[str]: """ Read-only property accessing the document's creator. If the document was converted to PDF from another format, this is the name of the application (e.g. OpenOffice) that created the original document from which it was converted. Returns a ``TextStringObject`` or ``None`` if the creator is not specified. """ return self._get_text(DI.CREATOR) @property def creator_raw(self) -> Optional[str]: """The "raw" version of creator; can return a ``ByteStringObject``.""" return self.get(DI.CREATOR) @property def producer(self) -> Optional[str]: """ Read-only property accessing the document's producer. If the document was converted to PDF from another format, this is the name of the application (for example, macOS Quartz) that converted it to PDF. Returns a ``TextStringObject`` or ``None`` if the producer is not specified. """ return self._get_text(DI.PRODUCER) @property def producer_raw(self) -> Optional[str]: """The "raw" version of producer; can return a ``ByteStringObject``.""" return self.get(DI.PRODUCER) @property def creation_date(self) -> Optional[datetime]: """Read-only property accessing the document's creation date.""" return parse_iso8824_date(self._get_text(DI.CREATION_DATE)) @property def creation_date_raw(self) -> Optional[str]: """ The "raw" version of creation date; can return a ``ByteStringObject``. Typically in the format ``D:YYYYMMDDhhmmss[+Z-]hh'mm`` where the suffix is the offset from UTC. """ return self.get(DI.CREATION_DATE) @property def modification_date(self) -> Optional[datetime]: """ Read-only property accessing the document's modification date. The date and time the document was most recently modified. """ return parse_iso8824_date(self._get_text(DI.MOD_DATE)) @property def modification_date_raw(self) -> Optional[str]: """ The "raw" version of modification date; can return a ``ByteStringObject``. Typically in the format ``D:YYYYMMDDhhmmss[+Z-]hh'mm`` where the suffix is the offset from UTC. """ return self.get(DI.MOD_DATE) @property def keywords(self) -> Optional[str]: """ Read-only property accessing the document's keywords. Returns a ``TextStringObject`` or ``None`` if keywords are not specified. """ return self._get_text(DI.KEYWORDS) @property def keywords_raw(self) -> Optional[str]: """The "raw" version of keywords; can return a ``ByteStringObject``.""" return self.get(DI.KEYWORDS) class PdfDocCommon: """ Common functions from PdfWriter and PdfReader objects. This root class is strongly abstracted. """ strict: bool = False # default flattened_pages: Optional[list[PageObject]] = None _encryption: Optional[Encryption] = None _readonly: bool = False @property @abstractmethod def root_object(self) -> DictionaryObject: ... # pragma: no cover @property @abstractmethod def pdf_header(self) -> str: ... # pragma: no cover @abstractmethod def get_object( self, indirect_reference: Union[int, IndirectObject] ) -> Optional[PdfObject]: ... # pragma: no cover @abstractmethod def _replace_object(self, indirect: IndirectObject, obj: PdfObject) -> PdfObject: ... # pragma: no cover @property @abstractmethod def _info(self) -> Optional[DictionaryObject]: ... # pragma: no cover @property def metadata(self) -> Optional[DocumentInformation]: """ Retrieve the PDF file's document information dictionary, if it exists. Note that some PDF files use metadata streams instead of document information dictionaries, and these metadata streams will not be accessed by this function. """ retval = DocumentInformation() if self._info is None: return None retval.update(self._info) return retval @property def xmp_metadata(self) -> Optional[XmpInformation]: ... # pragma: no cover @property def viewer_preferences(self) -> Optional[ViewerPreferences]: """Returns the existing ViewerPreferences as an overloaded dictionary.""" o = self.root_object.get(CD.VIEWER_PREFERENCES, None) if o is None: return None o = o.get_object() if not isinstance(o, ViewerPreferences): o = ViewerPreferences(o) if hasattr(o, "indirect_reference") and o.indirect_reference is not None: self._replace_object(o.indirect_reference, o) else: self.root_object[NameObject(CD.VIEWER_PREFERENCES)] = o return o def get_num_pages(self) -> int: """ Calculate the number of pages in this PDF file. Returns: The number of pages of the parsed PDF file. Raises: PdfReadError: If restrictions prevent this action. """ # Flattened pages will not work on an encrypted PDF; # the PDF file's page count is used in this case. Otherwise, # the original method (flattened page count) is used. if self.is_encrypted: return self.root_object["/Pages"]["/Count"] # type: ignore if self.flattened_pages is None: self._flatten(self._readonly) assert self.flattened_pages is not None return len(self.flattened_pages) def get_page(self, page_number: int) -> PageObject: """ Retrieve a page by number from this PDF file. Most of the time ``.pages[page_number]`` is preferred. Args: page_number: The page number to retrieve (pages begin at zero) Returns: A :class:`PageObject` instance. """ if self.flattened_pages is None: self._flatten(self._readonly) assert self.flattened_pages is not None, "hint for mypy" return self.flattened_pages[page_number] def _get_page_in_node( self, page_number: int, ) -> tuple[DictionaryObject, int]: """ Retrieve the node and position within the /Kids containing the page. If page_number is greater than the number of pages, it returns the top node, -1. """ top = cast(DictionaryObject, self.root_object["/Pages"]) def recursive_call( node: DictionaryObject, mi: int ) -> tuple[Optional[PdfObject], int]: ma = cast(int, node.get("/Count", 1)) # default 1 for /Page types if node["/Type"] == "/Page": if page_number == mi: return node, -1 return None, mi + 1 if (page_number - mi) >= ma: # not in nodes below if node == top: return top, -1 return None, mi + ma for idx, kid in enumerate(cast(ArrayObject, node["/Kids"])): kid = cast(DictionaryObject, kid.get_object()) n, i = recursive_call(kid, mi) if n is not None: # page has just been found ... if i < 0: # ... just below! return node, idx # ... at lower levels return n, i mi = i raise PyPdfError("Unexpectedly cannot find the node.") node, idx = recursive_call(top, 0) assert isinstance(node, DictionaryObject), "mypy" return node, idx @property def named_destinations(self) -> dict[str, Destination]: """A read-only dictionary which maps names to destinations.""" return self._get_named_destinations() def get_named_dest_root(self) -> ArrayObject: named_dest = ArrayObject() if CA.NAMES in self.root_object and isinstance( self.root_object[CA.NAMES], DictionaryObject ): names = cast(DictionaryObject, self.root_object[CA.NAMES]) if CA.DESTS in names and isinstance(names[CA.DESTS], DictionaryObject): # §3.6.3 Name Dictionary (PDF spec 1.7) dests = cast(DictionaryObject, names[CA.DESTS]) dests_ref = dests.indirect_reference if CA.NAMES in dests: # §7.9.6, entries in a name tree node dictionary named_dest = cast(ArrayObject, dests[CA.NAMES]) else: named_dest = ArrayObject() dests[NameObject(CA.NAMES)] = named_dest elif hasattr(self, "_add_object"): dests = DictionaryObject() dests_ref = self._add_object(dests) names[NameObject(CA.DESTS)] = dests_ref dests[NameObject(CA.NAMES)] = named_dest elif hasattr(self, "_add_object"): names = DictionaryObject() names_ref = self._add_object(names) self.root_object[NameObject(CA.NAMES)] = names_ref dests = DictionaryObject() dests_ref = self._add_object(dests) names[NameObject(CA.DESTS)] = dests_ref dests[NameObject(CA.NAMES)] = named_dest return named_dest ## common def _get_named_destinations( self, tree: Union[TreeObject, None] = None, retval: Optional[dict[str, Destination]] = None, ) -> dict[str, Destination]: """ Retrieve the named destinations present in the document. Args: tree: The current tree. retval: The previously retrieved destinations for nested calls. Returns: A dictionary which maps names to destinations. """ if retval is None: retval = {} catalog = self.root_object # get the name tree if CA.DESTS in catalog: tree = cast(TreeObject, catalog[CA.DESTS]) elif CA.NAMES in catalog: names = cast(DictionaryObject, catalog[CA.NAMES]) if CA.DESTS in names: tree = cast(TreeObject, names[CA.DESTS]) if is_null_or_none(tree): return retval assert tree is not None, "mypy" if PagesAttributes.KIDS in tree: # recurse down the tree for kid in cast(ArrayObject, tree[PagesAttributes.KIDS]): self._get_named_destinations(kid.get_object(), retval) # §7.9.6, entries in a name tree node dictionary elif CA.NAMES in tree: # /Kids and /Names are exclusives (§7.9.6) names = cast(DictionaryObject, tree[CA.NAMES]) i = 0 while i < len(names): key = names[i].get_object() i += 1 if not isinstance(key, (bytes, str)): continue try: value = names[i].get_object() except IndexError: break i += 1 if isinstance(value, DictionaryObject): if "/D" in value: value = value["/D"] else: continue dest = self._build_destination(key, value) if dest is not None: retval[cast(str, dest["/Title"])] = dest # Remain backwards-compatible. retval[str(key)] = dest else: # case where Dests is in root catalog (PDF 1.7 specs, §2 about PDF 1.1) for k__, v__ in tree.items(): val = v__.get_object() if isinstance(val, DictionaryObject): if "/D" in val: val = val["/D"].get_object() else: continue dest = self._build_destination(k__, val) if dest is not None: retval[k__] = dest return retval # A select group of relevant field attributes. For the complete list, # see §12.3.2 of the PDF 1.7 or PDF 2.0 specification. def get_fields( self, tree: Optional[TreeObject] = None, retval: Optional[dict[Any, Any]] = None, fileobj: Optional[Any] = None, stack: Optional[list[PdfObject]] = None, ) -> Optional[dict[str, Any]]: """ Extract field data if this PDF contains interactive form fields. The *tree*, *retval*, *stack* parameters are for recursive use. Args: tree: Current object to parse. retval: In-progress list of fields. fileobj: A file object (usually a text file) to write a report to on all interactive form fields found. stack: List of already parsed objects. Returns: A dictionary where each key is a field name, and each value is a :class:`Field` object. By default, the mapping name is used for keys. ``None`` if form data could not be located. """ field_attributes = FA.attributes_dict() field_attributes.update(CheckboxRadioButtonAttributes.attributes_dict()) if retval is None: retval = {} catalog = self.root_object stack = [] # get the AcroForm tree if CD.ACRO_FORM in catalog: tree = cast(Optional[TreeObject], catalog[CD.ACRO_FORM]) else: return None if tree is None: return retval assert stack is not None if "/Fields" in tree: fields = cast(ArrayObject, tree["/Fields"]) for f in fields: field = f.get_object() self._build_field(field, retval, fileobj, field_attributes, stack) elif any(attr in tree for attr in field_attributes): # Tree is a field self._build_field(tree, retval, fileobj, field_attributes, stack) return retval def _get_qualified_field_name(self, parent: DictionaryObject) -> str: if "/TM" in parent: return cast(str, parent["/TM"]) if "/Parent" in parent: return ( self._get_qualified_field_name( cast(DictionaryObject, parent["/Parent"]) ) + "." + cast(str, parent.get("/T", "")) ) return cast(str, parent.get("/T", "")) def _build_field( self, field: Union[TreeObject, DictionaryObject], retval: dict[Any, Any], fileobj: Any, field_attributes: Any, stack: list[PdfObject], ) -> None: if all(attr not in field for attr in ("/T", "/TM")): return key = self._get_qualified_field_name(field) if fileobj: self._write_field(fileobj, field, field_attributes) fileobj.write("\n") retval[key] = Field(field) obj = retval[key].indirect_reference.get_object() # to get the full object if obj.get(FA.FT, "") == "/Ch": retval[key][NameObject("/_States_")] = obj[NameObject(FA.Opt)] if obj.get(FA.FT, "") == "/Btn" and "/AP" in obj: # Checkbox retval[key][NameObject("/_States_")] = ArrayObject( list(obj["/AP"]["/N"].keys()) ) if "/Off" not in retval[key]["/_States_"]: retval[key][NameObject("/_States_")].append(NameObject("/Off")) elif obj.get(FA.FT, "") == "/Btn" and obj.get(FA.Ff, 0) & FA.FfBits.Radio != 0: states: list[str] = [] retval[key][NameObject("/_States_")] = ArrayObject(states) for k in obj.get(FA.Kids, {}): k = k.get_object() for s in list(k["/AP"]["/N"].keys()): if s not in states: states.append(s) retval[key][NameObject("/_States_")] = ArrayObject(states) if ( obj.get(FA.Ff, 0) & FA.FfBits.NoToggleToOff != 0 and "/Off" in retval[key]["/_States_"] ): del retval[key]["/_States_"][retval[key]["/_States_"].index("/Off")] # at last for order self._check_kids(field, retval, fileobj, stack) def _check_kids( self, tree: Union[TreeObject, DictionaryObject], retval: Any, fileobj: Any, stack: list[PdfObject], ) -> None: if tree in stack: logger_warning( f"{self._get_qualified_field_name(tree)} already parsed", __name__ ) return stack.append(tree) if PagesAttributes.KIDS in tree: # recurse down the tree for kid in tree[PagesAttributes.KIDS]: # type: ignore kid = kid.get_object() self.get_fields(kid, retval, fileobj, stack) def _write_field(self, fileobj: Any, field: Any, field_attributes: Any) -> None: field_attributes_tuple = FA.attributes() field_attributes_tuple = ( field_attributes_tuple + CheckboxRadioButtonAttributes.attributes() ) for attr in field_attributes_tuple: if attr in ( FA.Kids, FA.AA, ): continue attr_name = field_attributes[attr] try: if attr == FA.FT: # Make the field type value clearer types = { "/Btn": "Button", "/Tx": "Text", "/Ch": "Choice", "/Sig": "Signature", } if field[attr] in types: fileobj.write(f"{attr_name}: {types[field[attr]]}\n") elif attr == FA.Parent: # Let's just write the name of the parent try: name = field[attr][FA.TM] except KeyError: name = field[attr][FA.T] fileobj.write(f"{attr_name}: {name}\n") else: fileobj.write(f"{attr_name}: {field[attr]}\n") except KeyError: # Field attribute is N/A or unknown, so don't write anything pass def get_form_text_fields(self, full_qualified_name: bool = False) -> dict[str, Any]: """ Retrieve form fields from the document with textual data. Args: full_qualified_name: to get full name Returns: A dictionary. The key is the name of the form field, the value is the content of the field. If the document contains multiple form fields with the same name, the second and following will get the suffix .2, .3, ... """ def indexed_key(k: str, fields: dict[Any, Any]) -> str: if k not in fields: return k return ( k + "." + str(sum(1 for kk in fields if kk.startswith(k + ".")) + 2) ) # Retrieve document form fields formfields = self.get_fields() if formfields is None: return {} ff = {} for field, value in formfields.items(): if value.get("/FT") == "/Tx": if full_qualified_name: ff[field] = value.get("/V") else: ff[indexed_key(cast(str, value["/T"]), ff)] = value.get("/V") return ff def get_pages_showing_field( self, field: Union[Field, PdfObject, IndirectObject] ) -> list[PageObject]: """ Provides list of pages where the field is called. Args: field: Field Object, PdfObject or IndirectObject referencing a Field Returns: List of pages: - Empty list: The field has no widgets attached (either hidden field or ancestor field). - Single page list: Page where the widget is present (most common). - Multi-page list: Field with multiple kids widgets (example: radio buttons, field repeated on multiple pages). """ def _get_inherited(obj: DictionaryObject, key: str) -> Any: if key in obj: return obj[key] if "/Parent" in obj: return _get_inherited( cast(DictionaryObject, obj["/Parent"].get_object()), key ) return None try: # to cope with all types field = cast(DictionaryObject, field.indirect_reference.get_object()) # type: ignore except Exception as exc: raise ValueError("Field type is invalid") from exc if is_null_or_none(_get_inherited(field, "/FT")): raise ValueError("Field is not valid") ret = [] if field.get("/Subtype", "") == "/Widget": if "/P" in field: ret = [field["/P"].get_object()] else: ret = [ p for p in self.pages if field.indirect_reference in p.get("/Annots", "") ] else: kids = field.get("/Kids", ()) for k in kids: k = k.get_object() if (k.get("/Subtype", "") == "/Widget") and ("/T" not in k): # Kid that is just a widget, not a field: if "/P" in k: ret += [k["/P"].get_object()] else: ret += [ p for p in self.pages if k.indirect_reference in p.get("/Annots", "") ] return [ x if isinstance(x, PageObject) else (self.pages[self._get_page_number_by_indirect(x.indirect_reference)]) # type: ignore for x in ret ] @property def open_destination( self, ) -> Union[None, Destination, TextStringObject, ByteStringObject]: """ Property to access the opening destination (``/OpenAction`` entry in the PDF catalog). It returns ``None`` if the entry does not exist or is not set. Raises: Exception: If a destination is invalid. """ if "/OpenAction" not in self.root_object: return None oa: Any = self.root_object["/OpenAction"] if isinstance(oa, bytes): # pragma: no cover oa = oa.decode() if isinstance(oa, str): return create_string_object(oa) if isinstance(oa, ArrayObject): try: page, typ, *array = oa fit = Fit(typ, tuple(array)) return Destination("OpenAction", page, fit) except Exception as exc: raise Exception(f"Invalid Destination {oa}: {exc}") else: return None @open_destination.setter def open_destination(self, dest: Union[None, str, Destination, PageObject]) -> None: raise NotImplementedError("No setter for open_destination") @property def outline(self) -> OutlineType: """ Read-only property for the outline present in the document (i.e., a collection of 'outline items' which are also known as 'bookmarks'). """ return self._get_outline() def _get_outline( self, node: Optional[DictionaryObject] = None, outline: Optional[Any] = None ) -> OutlineType: if outline is None: outline = [] catalog = self.root_object # get the outline dictionary and named destinations if CO.OUTLINES in catalog: lines = cast(DictionaryObject, catalog[CO.OUTLINES]) if isinstance(lines, NullObject): return outline # §12.3.3 Document outline, entries in the outline dictionary if not is_null_or_none(lines) and "/First" in lines: node = cast(DictionaryObject, lines["/First"]) self._named_destinations = self._get_named_destinations() if node is None: return outline # see if there are any more outline items while True: outline_obj = self._build_outline_item(node) if outline_obj: outline.append(outline_obj) # check for sub-outline if "/First" in node: sub_outline: list[Any] = [] self._get_outline(cast(DictionaryObject, node["/First"]), sub_outline) if sub_outline: outline.append(sub_outline) if "/Next" not in node: break node = cast(DictionaryObject, node["/Next"]) return outline @property def threads(self) -> Optional[ArrayObject]: """ Read-only property for the list of threads. See §12.4.3 from the PDF 1.7 or 2.0 specification. It is an array of dictionaries with "/F" (the first bead in the thread) and "/I" (a thread information dictionary containing information about the thread, such as its title, author, and creation date) properties or None if there are no articles. Since PDF 2.0 it can also contain an indirect reference to a metadata stream containing information about the thread, such as its title, author, and creation date. """ catalog = self.root_object if CO.THREADS in catalog: return cast("ArrayObject", catalog[CO.THREADS]) return None @abstractmethod def _get_page_number_by_indirect( self, indirect_reference: Union[None, int, NullObject, IndirectObject] ) -> Optional[int]: ... # pragma: no cover def get_page_number(self, page: PageObject) -> Optional[int]: """ Retrieve page number of a given PageObject. Args: page: The page to get page number. Should be an instance of :class:`PageObject` Returns: The page number or None if page is not found """ return self._get_page_number_by_indirect(page.indirect_reference) def get_destination_page_number(self, destination: Destination) -> Optional[int]: """ Retrieve page number of a given Destination object. Args: destination: The destination to get page number. Returns: The page number or None if page is not found """ return self._get_page_number_by_indirect(destination.page) def _build_destination( self, title: Union[str, bytes], array: Optional[ list[ Union[NumberObject, IndirectObject, None, NullObject, DictionaryObject] ] ], ) -> Destination: page, typ = None, None # handle outline items with missing or invalid destination if ( isinstance(array, (NullObject, str)) or (isinstance(array, ArrayObject) and len(array) == 0) or array is None ): page = NullObject() return Destination(title, page, Fit.fit()) page, typ, *array = array # type: ignore try: return Destination(title, page, Fit(fit_type=typ, fit_args=array)) # type: ignore except PdfReadError: logger_warning(f"Unknown destination: {title!r} {array}", __name__) if self.strict: raise # create a link to first Page tmp = self.pages[0].indirect_reference indirect_reference = NullObject() if tmp is None else tmp return Destination(title, indirect_reference, Fit.fit()) def _build_outline_item(self, node: DictionaryObject) -> Optional[Destination]: dest, title, outline_item = None, None, None # title required for valid outline # §12.3.3, entries in an outline item dictionary try: title = cast("str", node["/Title"]) except KeyError: if self.strict: raise PdfReadError(f"Outline Entry Missing /Title attribute: {node!r}") title = "" if "/A" in node: # Action, PDF 1.7 and PDF 2.0 §12.6 (only type GoTo supported) action = cast(DictionaryObject, node["/A"]) action_type = cast(NameObject, action[GoToActionArguments.S]) if action_type == "/GoTo": if GoToActionArguments.D in action: dest = action[GoToActionArguments.D] elif self.strict: raise PdfReadError(f"Outline Action Missing /D attribute: {node!r}") elif "/Dest" in node: # Destination, PDF 1.7 and PDF 2.0 §12.3.2 dest = node["/Dest"] # if array was referenced in another object, will be a dict w/ key "/D" if isinstance(dest, DictionaryObject) and "/D" in dest: dest = dest["/D"] if isinstance(dest, ArrayObject): outline_item = self._build_destination(title, dest) elif isinstance(dest, str): # named destination, addresses NameObject Issue #193 # TODO: Keep named destination instead of replacing it? try: outline_item = self._build_destination( title, self._named_destinations[dest].dest_array ) except KeyError: # named destination not found in Name Dict outline_item = self._build_destination(title, None) elif dest is None: # outline item not required to have destination or action # PDFv1.7 Table 153 outline_item = self._build_destination(title, dest) else: if self.strict: raise PdfReadError(f"Unexpected destination {dest!r}") logger_warning( f"Removed unexpected destination {dest!r} from destination", __name__, ) outline_item = self._build_destination(title, None) # if outline item created, add color, format, and child count if present if outline_item: if "/C" in node: # Color of outline item font in (R, G, B) with values ranging 0.0-1.0 outline_item[NameObject("/C")] = ArrayObject(FloatObject(c) for c in node["/C"]) # type: ignore if "/F" in node: # specifies style characteristics bold and/or italic # with 1=italic, 2=bold, 3=both outline_item[NameObject("/F")] = node["/F"] if "/Count" in node: # absolute value = num. visible children # with positive = open/unfolded, negative = closed/folded outline_item[NameObject("/Count")] = node["/Count"] # if count is 0 we will consider it as open (to have available is_open) outline_item[NameObject("/%is_open%")] = BooleanObject( node.get("/Count", 0) >= 0 ) outline_item.node = node try: outline_item.indirect_reference = node.indirect_reference except AttributeError: pass return outline_item @property def pages(self) -> list[PageObject]: """ Property that emulates a list of :class:`PageObject`. This property allows to get a page or a range of pages. Note: For PdfWriter only: Provides the capability to remove a page/range of page from the list (using the del operator). Remember: Only the page entry is removed, as the objects beneath can be used elsewhere. A solution to completely remove them - if they are not used anywhere - is to write to a buffer/temporary file and then load it into a new PdfWriter. """ return _VirtualList(self.get_num_pages, self.get_page) # type: ignore @property def page_labels(self) -> list[str]: """ A list of labels for the pages in this document. This property is read-only. The labels are in the order that the pages appear in the document. """ return [page_index2page_label(self, i) for i in range(len(self.pages))] @property def page_layout(self) -> Optional[str]: """ Get the page layout currently being used. .. list-table:: Valid ``layout`` values :widths: 50 200 * - /NoLayout - Layout explicitly not specified * - /SinglePage - Show one page at a time * - /OneColumn - Show one column at a time * - /TwoColumnLeft - Show pages in two columns, odd-numbered pages on the left * - /TwoColumnRight - Show pages in two columns, odd-numbered pages on the right * - /TwoPageLeft - Show two pages at a time, odd-numbered pages on the left * - /TwoPageRight - Show two pages at a time, odd-numbered pages on the right """ try: return cast(NameObject, self.root_object[CD.PAGE_LAYOUT]) except KeyError: return None @property def page_mode(self) -> Optional[PagemodeType]: """ Get the page mode currently being used. .. list-table:: Valid ``mode`` values :widths: 50 200 * - /UseNone - Do not show outline or thumbnails panels * - /UseOutlines - Show outline (aka bookmarks) panel * - /UseThumbs - Show page thumbnails panel * - /FullScreen - Fullscreen view * - /UseOC - Show Optional Content Group (OCG) panel * - /UseAttachments - Show attachments panel """ try: return self.root_object["/PageMode"] # type: ignore except KeyError: return None def _flatten( self, list_only: bool = False, pages: Union[None, DictionaryObject, PageObject] = None, inherit: Optional[dict[str, Any]] = None, indirect_reference: Optional[IndirectObject] = None, ) -> None: """ Process the document pages to ease searching. Attributes of a page may inherit from ancestor nodes in the page tree. Flattening means moving any inheritance data into descendant nodes, effectively removing the inheritance dependency. Note: It is distinct from another use of "flattening" applied to PDFs. Flattening a PDF also means combining all the contents into one single layer and making the file less editable. Args: list_only: Will only list the pages within _flatten_pages. pages: inherit: indirect_reference: Used recursively to flatten the /Pages object. """ inheritable_page_attributes = ( NameObject(PG.RESOURCES), NameObject(PG.MEDIABOX), NameObject(PG.CROPBOX), NameObject(PG.ROTATE), ) if inherit is None: inherit = {} if pages is None: # Fix issue 327: set flattened_pages attribute only for # decrypted file catalog = self.root_object pages = catalog.get("/Pages").get_object() # type: ignore if not isinstance(pages, DictionaryObject): raise PdfReadError("Invalid object in /Pages") self.flattened_pages = [] if PagesAttributes.TYPE in pages: t = cast(str, pages[PagesAttributes.TYPE]) # if the page tree node has no /Type, consider as a page if /Kids is also missing elif PagesAttributes.KIDS not in pages: t = "/Page" else: t = "/Pages" if t == "/Pages": for attr in inheritable_page_attributes: if attr in pages: inherit[attr] = pages[attr] for page in cast(ArrayObject, pages[PagesAttributes.KIDS]): addt = {} if isinstance(page, IndirectObject): addt["indirect_reference"] = page obj = page.get_object() if obj: # damaged file may have invalid child in /Pages try: self._flatten(list_only, obj, inherit, **addt) except RecursionError: raise PdfReadError( "Maximum recursion depth reached during page flattening." ) elif t == "/Page": for attr_in, value in inherit.items(): # if the page has its own value, it does not inherit the # parent's value if attr_in not in pages: pages[attr_in] = value page_obj = PageObject(self, indirect_reference) if not list_only: page_obj.update(pages) # TODO: Could flattened_pages be None at this point? self.flattened_pages.append(page_obj) # type: ignore def remove_page( self, page: Union[int, PageObject, IndirectObject], clean: bool = False, ) -> None: """ Remove page from pages list. Args: page: * :class:`int`: Page number to be removed. * :class:`~pypdf._page.PageObject`: page to be removed. If the page appears many times only the first one will be removed. * :class:`~pypdf.generic.IndirectObject`: Reference to page to be removed. clean: replace PageObject with NullObject to prevent annotations or destinations to reference a detached page. """ if self.flattened_pages is None: self._flatten(self._readonly) assert self.flattened_pages is not None if isinstance(page, IndirectObject): p = page.get_object() if not isinstance(p, PageObject): logger_warning("IndirectObject is not referencing a page", __name__) return page = p if not isinstance(page, int): try: page = self.flattened_pages.index(page) except ValueError: logger_warning("Cannot find page in pages", __name__) return if not (0 <= page < len(self.flattened_pages)): logger_warning("Page number is out of range", __name__) return ind = self.pages[page].indirect_reference del self.pages[page] if clean and ind is not None: self._replace_object(ind, NullObject()) def _get_indirect_object(self, num: int, gen: int) -> Optional[PdfObject]: """ Used to ease development. This is equivalent to generic.IndirectObject(num,gen,self).get_object() Args: num: The object number of the indirect object. gen: The generation number of the indirect object. Returns: A PdfObject """ return IndirectObject(num, gen, self).get_object() def decode_permissions( self, permissions_code: int ) -> dict[str, bool]: # pragma: no cover """Take the permissions as an integer, return the allowed access.""" deprecation_with_replacement( old_name="decode_permissions", new_name="user_access_permissions", removed_in="5.0.0", ) permissions_mapping = { "print": UserAccessPermissions.PRINT, "modify": UserAccessPermissions.MODIFY, "copy": UserAccessPermissions.EXTRACT, "annotations": UserAccessPermissions.ADD_OR_MODIFY, "forms": UserAccessPermissions.FILL_FORM_FIELDS, # Do not fix typo, as part of official, but deprecated API. "accessability": UserAccessPermissions.EXTRACT_TEXT_AND_GRAPHICS, "assemble": UserAccessPermissions.ASSEMBLE_DOC, "print_high_quality": UserAccessPermissions.PRINT_TO_REPRESENTATION, } return { key: permissions_code & flag != 0 for key, flag in permissions_mapping.items() } @property def user_access_permissions(self) -> Optional[UserAccessPermissions]: """Get the user access permissions for encrypted documents. Returns None if not encrypted.""" if self._encryption is None: return None return UserAccessPermissions(self._encryption.P) @property @abstractmethod def is_encrypted(self) -> bool: """ Read-only boolean property showing whether this PDF file is encrypted. Note that this property, if true, will remain true even after the :meth:`decrypt()` method is called. """ ... # pragma: no cover @property def xfa(self) -> Optional[dict[str, Any]]: tree: Optional[TreeObject] = None retval: dict[str, Any] = {} catalog = self.root_object if "/AcroForm" not in catalog or not catalog["/AcroForm"]: return None tree = cast(TreeObject, catalog["/AcroForm"]) if "/XFA" in tree: fields = cast(ArrayObject, tree["/XFA"]) i = iter(fields) for f in i: tag = f f = next(i) if isinstance(f, IndirectObject): field = cast(Optional[EncodedStreamObject], f.get_object()) if field: es = zlib.decompress(field._data) retval[tag] = es return retval @property def attachments(self) -> Mapping[str, list[bytes]]: """Mapping of attachment filenames to their content.""" return LazyDict( { name: (self._get_attachment_list, name) for name in self._list_attachments() } ) @property def attachment_list(self) -> Generator[EmbeddedFile, None, None]: """Iterable of attachment objects.""" yield from EmbeddedFile._load(self.root_object) def _list_attachments(self) -> list[str]: """ Retrieves the list of filenames of file attachments. Returns: list of filenames """ names = [] for entry in self.attachment_list: names.append(entry.name) if (name := entry.alternative_name) != entry.name and name: names.append(name) return names def _get_attachment_list(self, name: str) -> list[bytes]: out = self._get_attachments(name)[name] if isinstance(out, list): return out return [out] def _get_attachments( self, filename: Optional[str] = None ) -> dict[str, Union[bytes, list[bytes]]]: """ Retrieves all or selected file attachments of the PDF as a dictionary of file names and the file data as a bytestring. Args: filename: If filename is None, then a dictionary of all attachments will be returned, where the key is the filename and the value is the content. Otherwise, a dictionary with just a single key - the filename - and its content will be returned. Returns: dictionary of filename -> Union[bytestring or List[ByteString]] If the filename exists multiple times a list of the different versions will be provided. """ attachments: dict[str, Union[bytes, list[bytes]]] = {} for entry in self.attachment_list: names = set() alternative_name = entry.alternative_name if filename is not None: if filename in {entry.name, alternative_name}: name = entry.name if filename == entry.name else alternative_name names.add(name) else: continue else: names = {entry.name, alternative_name} for name in names: if name is None: continue if name in attachments: if not isinstance(attachments[name], list): attachments[name] = [attachments[name]] # type:ignore attachments[name].append(entry.content) # type:ignore else: attachments[name] = entry.content return attachments @abstractmethod def _repr_mimebundle_( self, include: Union[None, Iterable[str]] = None, exclude: Union[None, Iterable[str]] = None, ) -> dict[str, Any]: """ Integration into Jupyter Notebooks. This method returns a dictionary that maps a mime-type to its representation. .. seealso:: https://ipython.readthedocs.io/en/stable/config/integrating.html """ ... # pragma: no cover class LazyDict(Mapping[Any, Any]): def __init__(self, *args: Any, **kwargs: Any) -> None: self._raw_dict = dict(*args, **kwargs) def __getitem__(self, key: str) -> Any: func, arg = self._raw_dict.__getitem__(key) return func(arg) def __iter__(self) -> Iterator[Any]: return iter(self._raw_dict) def __len__(self) -> int: return len(self._raw_dict) def __str__(self) -> str: return f"LazyDict(keys={list(self.keys())})" pypdf-6.1.2/pypdf/_encryption.py000066400000000000000000001371721507516550200167100ustar00rootroot00000000000000# Copyright (c) 2022, exiledkingcc # All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. import hashlib import secrets import struct from enum import Enum, IntEnum from typing import Any, Optional, Union, cast from pypdf._crypt_providers import ( CryptAES, CryptBase, CryptIdentity, CryptRC4, aes_cbc_decrypt, aes_cbc_encrypt, aes_ecb_decrypt, aes_ecb_encrypt, rc4_decrypt, rc4_encrypt, ) from ._utils import logger_warning from .generic import ( ArrayObject, ByteStringObject, DictionaryObject, NameObject, NumberObject, PdfObject, StreamObject, TextStringObject, create_string_object, ) class CryptFilter: def __init__( self, stm_crypt: CryptBase, str_crypt: CryptBase, ef_crypt: CryptBase, ) -> None: self.stm_crypt = stm_crypt self.str_crypt = str_crypt self.ef_crypt = ef_crypt def encrypt_object(self, obj: PdfObject) -> PdfObject: if isinstance(obj, ByteStringObject): data = self.str_crypt.encrypt(obj.original_bytes) obj = ByteStringObject(data) elif isinstance(obj, TextStringObject): data = self.str_crypt.encrypt(obj.get_encoded_bytes()) obj = ByteStringObject(data) elif isinstance(obj, StreamObject): obj2 = StreamObject() obj2.update(obj) obj2.set_data(self.stm_crypt.encrypt(obj._data)) for key, value in obj.items(): # Dont forget the Stream dict. obj2[key] = self.encrypt_object(value) obj = obj2 elif isinstance(obj, DictionaryObject): obj2 = DictionaryObject() # type: ignore for key, value in obj.items(): obj2[key] = self.encrypt_object(value) obj = obj2 elif isinstance(obj, ArrayObject): obj = ArrayObject(self.encrypt_object(x) for x in obj) return obj def decrypt_object(self, obj: PdfObject) -> PdfObject: if isinstance(obj, (ByteStringObject, TextStringObject)): data = self.str_crypt.decrypt(obj.original_bytes) obj = create_string_object(data) elif isinstance(obj, StreamObject): obj._data = self.stm_crypt.decrypt(obj._data) for key, value in obj.items(): # Dont forget the Stream dict. obj[key] = self.decrypt_object(value) elif isinstance(obj, DictionaryObject): for key, value in obj.items(): obj[key] = self.decrypt_object(value) elif isinstance(obj, ArrayObject): for i in range(len(obj)): obj[i] = self.decrypt_object(obj[i]) return obj _PADDING = ( b"\x28\xbf\x4e\x5e\x4e\x75\x8a\x41\x64\x00\x4e\x56\xff\xfa\x01\x08" b"\x2e\x2e\x00\xb6\xd0\x68\x3e\x80\x2f\x0c\xa9\xfe\x64\x53\x69\x7a" ) def _padding(data: bytes) -> bytes: return (data + _PADDING)[:32] class AlgV4: @staticmethod def compute_key( password: bytes, rev: int, key_size: int, o_entry: bytes, P: int, id1_entry: bytes, metadata_encrypted: bool, ) -> bytes: """ Algorithm 2: Computing an encryption key. a) Pad or truncate the password string to exactly 32 bytes. If the password string is more than 32 bytes long, use only its first 32 bytes; if it is less than 32 bytes long, pad it by appending the required number of additional bytes from the beginning of the following padding string: < 28 BF 4E 5E 4E 75 8A 41 64 00 4E 56 FF FA 01 08 2E 2E 00 B6 D0 68 3E 80 2F 0C A9 FE 64 53 69 7A > That is, if the password string is n bytes long, append the first 32 - n bytes of the padding string to the end of the password string. If the password string is empty (zero-length), meaning there is no user password, substitute the entire padding string in its place. b) Initialize the MD5 hash function and pass the result of step (a) as input to this function. c) Pass the value of the encryption dictionary’s O entry to the MD5 hash function. ("Algorithm 3: Computing the encryption dictionary’s O (owner password) value" shows how the O value is computed.) d) Convert the integer value of the P entry to a 32-bit unsigned binary number and pass these bytes to the MD5 hash function, low-order byte first. e) Pass the first element of the file’s file identifier array (the value of the ID entry in the document’s trailer dictionary; see Table 15) to the MD5 hash function. f) (Security handlers of revision 4 or greater) If document metadata is not being encrypted, pass 4 bytes with the value 0xFFFFFFFF to the MD5 hash function. g) Finish the hash. h) (Security handlers of revision 3 or greater) Do the following 50 times: Take the output from the previous MD5 hash and pass the first n bytes of the output as input into a new MD5 hash, where n is the number of bytes of the encryption key as defined by the value of the encryption dictionary’s Length entry. i) Set the encryption key to the first n bytes of the output from the final MD5 hash, where n shall always be 5 for security handlers of revision 2 but, for security handlers of revision 3 or greater, shall depend on the value of the encryption dictionary’s Length entry. Args: password: The encryption secret as a bytes-string rev: The encryption revision (see PDF standard) key_size: The size of the key in bytes o_entry: The owner entry P: A set of flags specifying which operations shall be permitted when the document is opened with user access. If bit 2 is set to 1, all other bits are ignored and all operations are permitted. If bit 2 is set to 0, permission for operations are based on the values of the remaining flags defined in Table 24. id1_entry: metadata_encrypted: A boolean indicating if the metadata is encrypted. Returns: The u_hash digest of length key_size """ a = _padding(password) u_hash = hashlib.md5(a) u_hash.update(o_entry) u_hash.update(struct.pack("= 4 and not metadata_encrypted: u_hash.update(b"\xff\xff\xff\xff") u_hash_digest = u_hash.digest() length = key_size // 8 if rev >= 3: for _ in range(50): u_hash_digest = hashlib.md5(u_hash_digest[:length]).digest() return u_hash_digest[:length] @staticmethod def compute_O_value_key(owner_password: bytes, rev: int, key_size: int) -> bytes: """ Algorithm 3: Computing the encryption dictionary’s O (owner password) value. a) Pad or truncate the owner password string as described in step (a) of "Algorithm 2: Computing an encryption key". If there is no owner password, use the user password instead. b) Initialize the MD5 hash function and pass the result of step (a) as input to this function. c) (Security handlers of revision 3 or greater) Do the following 50 times: Take the output from the previous MD5 hash and pass it as input into a new MD5 hash. d) Create an RC4 encryption key using the first n bytes of the output from the final MD5 hash, where n shall always be 5 for security handlers of revision 2 but, for security handlers of revision 3 or greater, shall depend on the value of the encryption dictionary’s Length entry. e) Pad or truncate the user password string as described in step (a) of "Algorithm 2: Computing an encryption key". f) Encrypt the result of step (e), using an RC4 encryption function with the encryption key obtained in step (d). g) (Security handlers of revision 3 or greater) Do the following 19 times: Take the output from the previous invocation of the RC4 function and pass it as input to a new invocation of the function; use an encryption key generated by taking each byte of the encryption key obtained in step (d) and performing an XOR (exclusive or) operation between that byte and the single-byte value of the iteration counter (from 1 to 19). h) Store the output from the final invocation of the RC4 function as the value of the O entry in the encryption dictionary. Args: owner_password: rev: The encryption revision (see PDF standard) key_size: The size of the key in bytes Returns: The RC4 key """ a = _padding(owner_password) o_hash_digest = hashlib.md5(a).digest() if rev >= 3: for _ in range(50): o_hash_digest = hashlib.md5(o_hash_digest).digest() return o_hash_digest[: key_size // 8] @staticmethod def compute_O_value(rc4_key: bytes, user_password: bytes, rev: int) -> bytes: """ See :func:`compute_O_value_key`. Args: rc4_key: user_password: rev: The encryption revision (see PDF standard) Returns: The RC4 encrypted """ a = _padding(user_password) rc4_enc = rc4_encrypt(rc4_key, a) if rev >= 3: for i in range(1, 20): key = bytes(x ^ i for x in rc4_key) rc4_enc = rc4_encrypt(key, rc4_enc) return rc4_enc @staticmethod def compute_U_value(key: bytes, rev: int, id1_entry: bytes) -> bytes: """ Algorithm 4: Computing the encryption dictionary’s U (user password) value. (Security handlers of revision 2) a) Create an encryption key based on the user password string, as described in "Algorithm 2: Computing an encryption key". b) Encrypt the 32-byte padding string shown in step (a) of "Algorithm 2: Computing an encryption key", using an RC4 encryption function with the encryption key from the preceding step. c) Store the result of step (b) as the value of the U entry in the encryption dictionary. Args: key: rev: The encryption revision (see PDF standard) id1_entry: Returns: The value """ if rev <= 2: return rc4_encrypt(key, _PADDING) """ Algorithm 5: Computing the encryption dictionary’s U (user password) value. (Security handlers of revision 3 or greater) a) Create an encryption key based on the user password string, as described in "Algorithm 2: Computing an encryption key". b) Initialize the MD5 hash function and pass the 32-byte padding string shown in step (a) of "Algorithm 2: Computing an encryption key" as input to this function. c) Pass the first element of the file’s file identifier array (the value of the ID entry in the document’s trailer dictionary; see Table 15) to the hash function and finish the hash. d) Encrypt the 16-byte result of the hash, using an RC4 encryption function with the encryption key from step (a). e) Do the following 19 times: Take the output from the previous invocation of the RC4 function and pass it as input to a new invocation of the function; use an encryption key generated by taking each byte of the original encryption key obtained in step (a) and performing an XOR (exclusive or) operation between that byte and the single-byte value of the iteration counter (from 1 to 19). f) Append 16 bytes of arbitrary padding to the output from the final invocation of the RC4 function and store the 32-byte result as the value of the U entry in the encryption dictionary. """ u_hash = hashlib.md5(_PADDING) u_hash.update(id1_entry) rc4_enc = rc4_encrypt(key, u_hash.digest()) for i in range(1, 20): rc4_key = bytes(x ^ i for x in key) rc4_enc = rc4_encrypt(rc4_key, rc4_enc) return _padding(rc4_enc) @staticmethod def verify_user_password( user_password: bytes, rev: int, key_size: int, o_entry: bytes, u_entry: bytes, P: int, id1_entry: bytes, metadata_encrypted: bool, ) -> bytes: """ Algorithm 6: Authenticating the user password. a) Perform all but the last step of "Algorithm 4: Computing the encryption dictionary’s U (user password) value (Security handlers of revision 2)" or "Algorithm 5: Computing the encryption dictionary’s U (user password) value (Security handlers of revision 3 or greater)" using the supplied password string. b) If the result of step (a) is equal to the value of the encryption dictionary’s U entry (comparing on the first 16 bytes in the case of security handlers of revision 3 or greater), the password supplied is the correct user password. The key obtained in step (a) (that is, in the first step of "Algorithm 4: Computing the encryption dictionary’s U (user password) value (Security handlers of revision 2)" or "Algorithm 5: Computing the encryption dictionary’s U (user password) value (Security handlers of revision 3 or greater)") shall be used to decrypt the document. Args: user_password: The user password as a bytes stream rev: The encryption revision (see PDF standard) key_size: The size of the key in bytes o_entry: The owner entry u_entry: The user entry P: A set of flags specifying which operations shall be permitted when the document is opened with user access. If bit 2 is set to 1, all other bits are ignored and all operations are permitted. If bit 2 is set to 0, permission for operations are based on the values of the remaining flags defined in Table 24. id1_entry: metadata_encrypted: A boolean indicating if the metadata is encrypted. Returns: The key """ key = AlgV4.compute_key( user_password, rev, key_size, o_entry, P, id1_entry, metadata_encrypted ) u_value = AlgV4.compute_U_value(key, rev, id1_entry) if rev >= 3: u_value = u_value[:16] u_entry = u_entry[:16] if u_value != u_entry: key = b"" return key @staticmethod def verify_owner_password( owner_password: bytes, rev: int, key_size: int, o_entry: bytes, u_entry: bytes, P: int, id1_entry: bytes, metadata_encrypted: bool, ) -> bytes: """ Algorithm 7: Authenticating the owner password. a) Compute an encryption key from the supplied password string, as described in steps (a) to (d) of "Algorithm 3: Computing the encryption dictionary’s O (owner password) value". b) (Security handlers of revision 2 only) Decrypt the value of the encryption dictionary’s O entry, using an RC4 encryption function with the encryption key computed in step (a). (Security handlers of revision 3 or greater) Do the following 20 times: Decrypt the value of the encryption dictionary’s O entry (first iteration) or the output from the previous iteration (all subsequent iterations), using an RC4 encryption function with a different encryption key at each iteration. The key shall be generated by taking the original key (obtained in step (a)) and performing an XOR (exclusive or) operation between each byte of the key and the single-byte value of the iteration counter (from 19 to 0). c) The result of step (b) purports to be the user password. Authenticate this user password using "Algorithm 6: Authenticating the user password". If it is correct, the password supplied is the correct owner password. Args: owner_password: rev: The encryption revision (see PDF standard) key_size: The size of the key in bytes o_entry: The owner entry u_entry: The user entry P: A set of flags specifying which operations shall be permitted when the document is opened with user access. If bit 2 is set to 1, all other bits are ignored and all operations are permitted. If bit 2 is set to 0, permission for operations are based on the values of the remaining flags defined in Table 24. id1_entry: metadata_encrypted: A boolean indicating if the metadata is encrypted. Returns: bytes """ rc4_key = AlgV4.compute_O_value_key(owner_password, rev, key_size) if rev <= 2: user_password = rc4_decrypt(rc4_key, o_entry) else: user_password = o_entry for i in range(19, -1, -1): key = bytes(x ^ i for x in rc4_key) user_password = rc4_decrypt(key, user_password) return AlgV4.verify_user_password( user_password, rev, key_size, o_entry, u_entry, P, id1_entry, metadata_encrypted, ) class AlgV5: @staticmethod def verify_owner_password( R: int, password: bytes, o_value: bytes, oe_value: bytes, u_value: bytes ) -> bytes: """ Algorithm 3.2a Computing an encryption key. To understand the algorithm below, it is necessary to treat the O and U strings in the Encrypt dictionary as made up of three sections. The first 32 bytes are a hash value (explained below). The next 8 bytes are called the Validation Salt. The final 8 bytes are called the Key Salt. 1. The password string is generated from Unicode input by processing the input string with the SASLprep (IETF RFC 4013) profile of stringprep (IETF RFC 3454), and then converting to a UTF-8 representation. 2. Truncate the UTF-8 representation to 127 bytes if it is longer than 127 bytes. 3. Test the password against the owner key by computing the SHA-256 hash of the UTF-8 password concatenated with the 8 bytes of owner Validation Salt, concatenated with the 48-byte U string. If the 32-byte result matches the first 32 bytes of the O string, this is the owner password. Compute an intermediate owner key by computing the SHA-256 hash of the UTF-8 password concatenated with the 8 bytes of owner Key Salt, concatenated with the 48-byte U string. The 32-byte result is the key used to decrypt the 32-byte OE string using AES-256 in CBC mode with no padding and an initialization vector of zero. The 32-byte result is the file encryption key. 4. Test the password against the user key by computing the SHA-256 hash of the UTF-8 password concatenated with the 8 bytes of user Validation Salt. If the 32 byte result matches the first 32 bytes of the U string, this is the user password. Compute an intermediate user key by computing the SHA-256 hash of the UTF-8 password concatenated with the 8 bytes of user Key Salt. The 32-byte result is the key used to decrypt the 32-byte UE string using AES-256 in CBC mode with no padding and an initialization vector of zero. The 32-byte result is the file encryption key. 5. Decrypt the 16-byte Perms string using AES-256 in ECB mode with an initialization vector of zero and the file encryption key as the key. Verify that bytes 9-11 of the result are the characters â€a’, â€d’, â€b’. Bytes 0-3 of the decrypted Perms entry, treated as a little-endian integer, are the user permissions. They should match the value in the P key. Args: R: A number specifying which revision of the standard security handler shall be used to interpret this dictionary password: The owner password o_value: A 32-byte string, based on both the owner and user passwords, that shall be used in computing the encryption key and in determining whether a valid owner password was entered oe_value: u_value: A 32-byte string, based on the user password, that shall be used in determining whether to prompt the user for a password and, if so, whether a valid user or owner password was entered. Returns: The key """ password = password[:127] if ( AlgV5.calculate_hash(R, password, o_value[32:40], u_value[:48]) != o_value[:32] ): return b"" iv = bytes(0 for _ in range(16)) tmp_key = AlgV5.calculate_hash(R, password, o_value[40:48], u_value[:48]) return aes_cbc_decrypt(tmp_key, iv, oe_value) @staticmethod def verify_user_password( R: int, password: bytes, u_value: bytes, ue_value: bytes ) -> bytes: """ See :func:`verify_owner_password`. Args: R: A number specifying which revision of the standard security handler shall be used to interpret this dictionary password: The user password u_value: A 32-byte string, based on the user password, that shall be used in determining whether to prompt the user for a password and, if so, whether a valid user or owner password was entered. ue_value: Returns: bytes """ password = password[:127] if AlgV5.calculate_hash(R, password, u_value[32:40], b"") != u_value[:32]: return b"" iv = bytes(0 for _ in range(16)) tmp_key = AlgV5.calculate_hash(R, password, u_value[40:48], b"") return aes_cbc_decrypt(tmp_key, iv, ue_value) @staticmethod def calculate_hash(R: int, password: bytes, salt: bytes, udata: bytes) -> bytes: # https://github.com/qpdf/qpdf/blob/main/libqpdf/QPDF_encryption.cc k = hashlib.sha256(password + salt + udata).digest() if R < 6: return k count = 0 while True: count += 1 k1 = password + k + udata e = aes_cbc_encrypt(k[:16], k[16:32], k1 * 64) hash_fn = ( hashlib.sha256, hashlib.sha384, hashlib.sha512, )[sum(e[:16]) % 3] k = hash_fn(e).digest() if count >= 64 and e[-1] <= count - 32: break return k[:32] @staticmethod def verify_perms( key: bytes, perms: bytes, p: int, metadata_encrypted: bool ) -> bool: """ See :func:`verify_owner_password` and :func:`compute_perms_value`. Args: key: The owner password perms: p: A set of flags specifying which operations shall be permitted when the document is opened with user access. If bit 2 is set to 1, all other bits are ignored and all operations are permitted. If bit 2 is set to 0, permission for operations are based on the values of the remaining flags defined in Table 24. metadata_encrypted: Returns: A boolean """ b8 = b"T" if metadata_encrypted else b"F" p1 = struct.pack(" dict[Any, Any]: user_password = user_password[:127] owner_password = owner_password[:127] u_value, ue_value = AlgV5.compute_U_value(R, user_password, key) o_value, oe_value = AlgV5.compute_O_value(R, owner_password, key, u_value) perms = AlgV5.compute_Perms_value(key, p, metadata_encrypted) return { "/U": u_value, "/UE": ue_value, "/O": o_value, "/OE": oe_value, "/Perms": perms, } @staticmethod def compute_U_value(R: int, password: bytes, key: bytes) -> tuple[bytes, bytes]: """ Algorithm 3.8 Computing the encryption dictionary’s U (user password) and UE (user encryption key) values. 1. Generate 16 random bytes of data using a strong random number generator. The first 8 bytes are the User Validation Salt. The second 8 bytes are the User Key Salt. Compute the 32-byte SHA-256 hash of the password concatenated with the User Validation Salt. The 48-byte string consisting of the 32-byte hash followed by the User Validation Salt followed by the User Key Salt is stored as the U key. 2. Compute the 32-byte SHA-256 hash of the password concatenated with the User Key Salt. Using this hash as the key, encrypt the file encryption key using AES-256 in CBC mode with no padding and an initialization vector of zero. The resulting 32-byte string is stored as the UE key. Args: R: password: key: Returns: A tuple (u-value, ue value) """ random_bytes = secrets.token_bytes(16) val_salt = random_bytes[:8] key_salt = random_bytes[8:] u_value = AlgV5.calculate_hash(R, password, val_salt, b"") + val_salt + key_salt tmp_key = AlgV5.calculate_hash(R, password, key_salt, b"") iv = bytes(0 for _ in range(16)) ue_value = aes_cbc_encrypt(tmp_key, iv, key) return u_value, ue_value @staticmethod def compute_O_value( R: int, password: bytes, key: bytes, u_value: bytes ) -> tuple[bytes, bytes]: """ Algorithm 3.9 Computing the encryption dictionary’s O (owner password) and OE (owner encryption key) values. 1. Generate 16 random bytes of data using a strong random number generator. The first 8 bytes are the Owner Validation Salt. The second 8 bytes are the Owner Key Salt. Compute the 32-byte SHA-256 hash of the password concatenated with the Owner Validation Salt and then concatenated with the 48-byte U string as generated in Algorithm 3.8. The 48-byte string consisting of the 32-byte hash followed by the Owner Validation Salt followed by the Owner Key Salt is stored as the O key. 2. Compute the 32-byte SHA-256 hash of the password concatenated with the Owner Key Salt and then concatenated with the 48-byte U string as generated in Algorithm 3.8. Using this hash as the key, encrypt the file encryption key using AES-256 in CBC mode with no padding and an initialization vector of zero. The resulting 32-byte string is stored as the OE key. Args: R: password: key: u_value: A 32-byte string, based on the user password, that shall be used in determining whether to prompt the user for a password and, if so, whether a valid user or owner password was entered. Returns: A tuple (O value, OE value) """ random_bytes = secrets.token_bytes(16) val_salt = random_bytes[:8] key_salt = random_bytes[8:] o_value = ( AlgV5.calculate_hash(R, password, val_salt, u_value) + val_salt + key_salt ) tmp_key = AlgV5.calculate_hash(R, password, key_salt, u_value[:48]) iv = bytes(0 for _ in range(16)) oe_value = aes_cbc_encrypt(tmp_key, iv, key) return o_value, oe_value @staticmethod def compute_Perms_value(key: bytes, p: int, metadata_encrypted: bool) -> bytes: """ Algorithm 3.10 Computing the encryption dictionary’s Perms (permissions) value. 1. Extend the permissions (contents of the P integer) to 64 bits by setting the upper 32 bits to all 1’s. (This allows for future extension without changing the format.) 2. Record the 8 bytes of permission in the bytes 0-7 of the block, low order byte first. 3. Set byte 8 to the ASCII value ' T ' or ' F ' according to the EncryptMetadata Boolean. 4. Set bytes 9-11 to the ASCII characters ' a ', ' d ', ' b '. 5. Set bytes 12-15 to 4 bytes of random data, which will be ignored. 6. Encrypt the 16-byte block using AES-256 in ECB mode with an initialization vector of zero, using the file encryption key as the key. The result (16 bytes) is stored as the Perms string, and checked for validity when the file is opened. Args: key: p: A set of flags specifying which operations shall be permitted when the document is opened with user access. If bit 2 is set to 1, all other bits are ignored and all operations are permitted. If bit 2 is set to 0, permission for operations are based on the values of the remaining flags defined in Table 24. metadata_encrypted: A boolean indicating if the metadata is encrypted. Returns: The perms value """ b8 = b"T" if metadata_encrypted else b"F" rr = secrets.token_bytes(4) data = struct.pack(" None: # §7.6.2, entries common to all encryption dictionaries # use same name as keys of encryption dictionaries entries self.V = V self.R = R self.Length = Length # key_size self.P = (P + 0x100000000) % 0x100000000 # maybe P < 0 self.EncryptMetadata = EncryptMetadata self.id1_entry = first_id_entry self.StmF = StmF self.StrF = StrF self.EFF = EFF self.values: EncryptionValues = values if values else EncryptionValues() self._password_type = PasswordType.NOT_DECRYPTED self._key: Optional[bytes] = None def is_decrypted(self) -> bool: return self._password_type != PasswordType.NOT_DECRYPTED def encrypt_object(self, obj: PdfObject, idnum: int, generation: int) -> PdfObject: # skip calculate key if not self._is_encryption_object(obj): return obj cf = self._make_crypt_filter(idnum, generation) return cf.encrypt_object(obj) def decrypt_object(self, obj: PdfObject, idnum: int, generation: int) -> PdfObject: # skip calculate key if not self._is_encryption_object(obj): return obj cf = self._make_crypt_filter(idnum, generation) return cf.decrypt_object(obj) @staticmethod def _is_encryption_object(obj: PdfObject) -> bool: return isinstance( obj, ( ByteStringObject, TextStringObject, StreamObject, ArrayObject, DictionaryObject, ), ) def _make_crypt_filter(self, idnum: int, generation: int) -> CryptFilter: """ Algorithm 1: Encryption of data using the RC4 or AES algorithms. a) Obtain the object number and generation number from the object identifier of the string or stream to be encrypted (see 7.3.10, "Indirect Objects"). If the string is a direct object, use the identifier of the indirect object containing it. b) For all strings and streams without crypt filter specifier; treating the object number and generation number as binary integers, extend the original n-byte encryption key to n + 5 bytes by appending the low-order 3 bytes of the object number and the low-order 2 bytes of the generation number in that order, low-order byte first. (n is 5 unless the value of V in the encryption dictionary is greater than 1, in which case n is the value of Length divided by 8.) If using the AES algorithm, extend the encryption key an additional 4 bytes by adding the value “sAlT”, which corresponds to the hexadecimal values 0x73, 0x41, 0x6C, 0x54. (This addition is done for backward compatibility and is not intended to provide additional security.) c) Initialize the MD5 hash function and pass the result of step (b) as input to this function. d) Use the first (n + 5) bytes, up to a maximum of 16, of the output from the MD5 hash as the key for the RC4 or AES symmetric key algorithms, along with the string or stream data to be encrypted. If using the AES algorithm, the Cipher Block Chaining (CBC) mode, which requires an initialization vector, is used. The block size parameter is set to 16 bytes, and the initialization vector is a 16-byte random number that is stored as the first 16 bytes of the encrypted stream or string. Algorithm 3.1a Encryption of data using the AES algorithm 1. Use the 32-byte file encryption key for the AES-256 symmetric key algorithm, along with the string or stream data to be encrypted. Use the AES algorithm in Cipher Block Chaining (CBC) mode, which requires an initialization vector. The block size parameter is set to 16 bytes, and the initialization vector is a 16-byte random number that is stored as the first 16 bytes of the encrypted stream or string. The output is the encrypted data to be stored in the PDF file. """ pack1 = struct.pack(" CryptBase: if method == "/AESV2": return CryptAES(aes128_key) if method == "/AESV3": return CryptAES(aes256_key) if method == "/Identity": return CryptIdentity() return CryptRC4(rc4_key) @staticmethod def _encode_password(password: Union[bytes, str]) -> bytes: if isinstance(password, str): try: pwd = password.encode("latin-1") except Exception: pwd = password.encode("utf-8") else: pwd = password return pwd def verify(self, password: Union[bytes, str]) -> PasswordType: pwd = self._encode_password(password) key, rc = self.verify_v4(pwd) if self.V <= 4 else self.verify_v5(pwd) if rc != PasswordType.NOT_DECRYPTED: self._password_type = rc self._key = key return rc def verify_v4(self, password: bytes) -> tuple[bytes, PasswordType]: # verify owner password first key = AlgV4.verify_owner_password( password, self.R, self.Length, self.values.O, self.values.U, self.P, self.id1_entry, self.EncryptMetadata, ) if key: return key, PasswordType.OWNER_PASSWORD key = AlgV4.verify_user_password( password, self.R, self.Length, self.values.O, self.values.U, self.P, self.id1_entry, self.EncryptMetadata, ) if key: return key, PasswordType.USER_PASSWORD return b"", PasswordType.NOT_DECRYPTED def verify_v5(self, password: bytes) -> tuple[bytes, PasswordType]: # TODO: use SASLprep process # verify owner password first key = AlgV5.verify_owner_password( self.R, password, self.values.O, self.values.OE, self.values.U ) rc = PasswordType.OWNER_PASSWORD if not key: key = AlgV5.verify_user_password( self.R, password, self.values.U, self.values.UE ) rc = PasswordType.USER_PASSWORD if not key: return b"", PasswordType.NOT_DECRYPTED # verify Perms if not AlgV5.verify_perms(key, self.values.Perms, self.P, self.EncryptMetadata): logger_warning("ignore '/Perms' verify failed", __name__) return key, rc def write_entry( self, user_password: str, owner_password: Optional[str] ) -> DictionaryObject: user_pwd = self._encode_password(user_password) owner_pwd = self._encode_password(owner_password) if owner_password else None if owner_pwd is None: owner_pwd = user_pwd if self.V <= 4: self.compute_values_v4(user_pwd, owner_pwd) else: self._key = secrets.token_bytes(self.Length // 8) values = AlgV5.generate_values( self.R, user_pwd, owner_pwd, self._key, self.P, self.EncryptMetadata ) self.values.O = values["/O"] self.values.U = values["/U"] self.values.OE = values["/OE"] self.values.UE = values["/UE"] self.values.Perms = values["/Perms"] dict_obj = DictionaryObject() dict_obj[NameObject("/V")] = NumberObject(self.V) dict_obj[NameObject("/R")] = NumberObject(self.R) dict_obj[NameObject("/Length")] = NumberObject(self.Length) dict_obj[NameObject("/P")] = NumberObject(self.P) dict_obj[NameObject("/Filter")] = NameObject("/Standard") # ignore /EncryptMetadata dict_obj[NameObject("/O")] = ByteStringObject(self.values.O) dict_obj[NameObject("/U")] = ByteStringObject(self.values.U) if self.V >= 4: # TODO: allow different method std_cf = DictionaryObject() std_cf[NameObject("/AuthEvent")] = NameObject("/DocOpen") std_cf[NameObject("/CFM")] = NameObject(self.StmF) std_cf[NameObject("/Length")] = NumberObject(self.Length // 8) cf = DictionaryObject() cf[NameObject("/StdCF")] = std_cf dict_obj[NameObject("/CF")] = cf dict_obj[NameObject("/StmF")] = NameObject("/StdCF") dict_obj[NameObject("/StrF")] = NameObject("/StdCF") # ignore EFF # dict_obj[NameObject("/EFF")] = NameObject("/StdCF") if self.V >= 5: dict_obj[NameObject("/OE")] = ByteStringObject(self.values.OE) dict_obj[NameObject("/UE")] = ByteStringObject(self.values.UE) dict_obj[NameObject("/Perms")] = ByteStringObject(self.values.Perms) return dict_obj def compute_values_v4(self, user_password: bytes, owner_password: bytes) -> None: rc4_key = AlgV4.compute_O_value_key(owner_password, self.R, self.Length) o_value = AlgV4.compute_O_value(rc4_key, user_password, self.R) key = AlgV4.compute_key( user_password, self.R, self.Length, o_value, self.P, self.id1_entry, self.EncryptMetadata, ) u_value = AlgV4.compute_U_value(key, self.R, self.id1_entry) self._key = key self.values.O = o_value self.values.U = u_value @staticmethod def read(encryption_entry: DictionaryObject, first_id_entry: bytes) -> "Encryption": if encryption_entry.get("/Filter") != "/Standard": raise NotImplementedError( "only Standard PDF encryption handler is available" ) if "/SubFilter" in encryption_entry: raise NotImplementedError("/SubFilter NOT supported") stm_filter = "/V2" str_filter = "/V2" ef_filter = "/V2" alg_ver = encryption_entry.get("/V", 0) if alg_ver not in (1, 2, 3, 4, 5): raise NotImplementedError(f"Encryption V={alg_ver} NOT supported") if alg_ver >= 4: filters = encryption_entry["/CF"] stm_filter = encryption_entry.get("/StmF", "/Identity") str_filter = encryption_entry.get("/StrF", "/Identity") ef_filter = encryption_entry.get("/EFF", stm_filter) if stm_filter != "/Identity": stm_filter = filters[stm_filter]["/CFM"] # type: ignore if str_filter != "/Identity": str_filter = filters[str_filter]["/CFM"] # type: ignore if ef_filter != "/Identity": ef_filter = filters[ef_filter]["/CFM"] # type: ignore allowed_methods = ("/Identity", "/V2", "/AESV2", "/AESV3") if stm_filter not in allowed_methods: raise NotImplementedError(f"StmF Method {stm_filter} NOT supported!") if str_filter not in allowed_methods: raise NotImplementedError(f"StrF Method {str_filter} NOT supported!") if ef_filter not in allowed_methods: raise NotImplementedError(f"EFF Method {ef_filter} NOT supported!") alg_rev = cast(int, encryption_entry["/R"]) perm_flags = cast(int, encryption_entry["/P"]) key_bits = encryption_entry.get("/Length", 40) encrypt_metadata = encryption_entry.get("/EncryptMetadata") encrypt_metadata = ( encrypt_metadata.value if encrypt_metadata is not None else True ) values = EncryptionValues() values.O = cast(ByteStringObject, encryption_entry["/O"]).original_bytes values.U = cast(ByteStringObject, encryption_entry["/U"]).original_bytes values.OE = encryption_entry.get("/OE", ByteStringObject()).original_bytes values.UE = encryption_entry.get("/UE", ByteStringObject()).original_bytes values.Perms = encryption_entry.get("/Perms", ByteStringObject()).original_bytes return Encryption( V=alg_ver, R=alg_rev, Length=key_bits, P=perm_flags, EncryptMetadata=encrypt_metadata, first_id_entry=first_id_entry, values=values, StrF=str_filter, StmF=stm_filter, EFF=ef_filter, entry=encryption_entry, # Dummy entry for the moment; will get removed ) @staticmethod def make( alg: EncryptAlgorithm, permissions: int, first_id_entry: bytes ) -> "Encryption": alg_ver, alg_rev, key_bits = alg stm_filter, str_filter, ef_filter = "/V2", "/V2", "/V2" if alg == EncryptAlgorithm.AES_128: stm_filter, str_filter, ef_filter = "/AESV2", "/AESV2", "/AESV2" elif alg in (EncryptAlgorithm.AES_256_R5, EncryptAlgorithm.AES_256): stm_filter, str_filter, ef_filter = "/AESV3", "/AESV3", "/AESV3" return Encryption( V=alg_ver, R=alg_rev, Length=key_bits, P=permissions, EncryptMetadata=True, first_id_entry=first_id_entry, values=None, StrF=str_filter, StmF=stm_filter, EFF=ef_filter, entry=DictionaryObject(), # Dummy entry for the moment; will get removed ) pypdf-6.1.2/pypdf/_font.py000066400000000000000000000025121507516550200154510ustar00rootroot00000000000000from dataclasses import dataclass, field from typing import Optional from pypdf.generic import DictionaryObject @dataclass(frozen=True) class FontDescriptor: """ Represents the FontDescriptor dictionary as defined in the PDF specification. This contains both descriptive and metric information. The defaults are derived from the mean values of the 14 core fonts, rounded to 100. """ name: str = "Unknown" family: str = "Unknown" weight: str = "Unknown" ascent: float = 700.0 descent: float = -200.0 cap_height: float = 600.0 x_height: float = 500.0 italic_angle: float = 0.0 # Non-italic flags: int = 32 # Non-serif, non-symbolic, not fixed width bbox: tuple[float, float, float, float] = field(default_factory=lambda: (-100.0, -200.0, 1000.0, 900.0)) character_widths: dict[str, int] = field(default_factory=dict) @classmethod def from_font_resource(cls, pdf_font_dict: DictionaryObject) -> "Optional[FontDescriptor]": from pypdf._codecs.core_fontmetrics import CORE_FONT_METRICS # noqa: PLC0415 # Prioritize information from the PDF font dictionary font_name = pdf_font_dict.get("/BaseFont", "Unknown") if font_name[1:] in CORE_FONT_METRICS: return CORE_FONT_METRICS.get(font_name[1:]) return cls(name=font_name) pypdf-6.1.2/pypdf/_page.py000066400000000000000000002555371507516550200154400ustar00rootroot00000000000000# Copyright (c) 2006, Mathieu Fenniak # Copyright (c) 2007, Ashish Kulkarni # # All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. import math from collections.abc import Iterable, Iterator, Sequence from dataclasses import dataclass from decimal import Decimal from io import BytesIO from pathlib import Path from typing import ( Any, Callable, Literal, Optional, Union, cast, overload, ) from ._cmap import ( build_char_map, ) from ._protocols import PdfCommonDocProtocol from ._text_extraction import ( _layout_mode, ) from ._text_extraction._text_extractor import TextExtraction from ._utils import ( CompressedTransformationMatrix, TransformationMatrixType, _human_readable_bytes, logger_warning, matrix_multiply, ) from .constants import _INLINE_IMAGE_KEY_MAPPING, _INLINE_IMAGE_VALUE_MAPPING from .constants import AnnotationDictionaryAttributes as ADA from .constants import ImageAttributes as IA from .constants import PageAttributes as PG from .constants import Resources as RES from .errors import PageSizeNotDefinedError, PdfReadError from .filters import _xobj_to_image from .generic import ( ArrayObject, ContentStream, DictionaryObject, EncodedStreamObject, FloatObject, IndirectObject, NameObject, NullObject, NumberObject, PdfObject, RectangleObject, StreamObject, is_null_or_none, ) try: from PIL.Image import Image pil_not_imported = False except ImportError: Image = object # type: ignore pil_not_imported = True # error will be raised only when using images MERGE_CROP_BOX = "cropbox" # pypdf <= 3.4.0 used "trimbox" def _get_rectangle(self: Any, name: str, defaults: Iterable[str]) -> RectangleObject: retval: Union[None, RectangleObject, IndirectObject] = self.get(name) if isinstance(retval, RectangleObject): return retval if is_null_or_none(retval): for d in defaults: retval = self.get(d) if retval is not None: break if isinstance(retval, IndirectObject): retval = self.pdf.get_object(retval) retval = RectangleObject(retval) # type: ignore _set_rectangle(self, name, retval) return retval def _set_rectangle(self: Any, name: str, value: Union[RectangleObject, float]) -> None: self[NameObject(name)] = value def _delete_rectangle(self: Any, name: str) -> None: del self[name] def _create_rectangle_accessor(name: str, fallback: Iterable[str]) -> property: return property( lambda self: _get_rectangle(self, name, fallback), lambda self, value: _set_rectangle(self, name, value), lambda self: _delete_rectangle(self, name), ) class Transformation: """ Represent a 2D transformation. The transformation between two coordinate systems is represented by a 3-by-3 transformation matrix with the following form:: a b 0 c d 0 e f 1 Because a transformation matrix has only six elements that can be changed, it is usually specified in PDF as the six-element array [ a b c d e f ]. Coordinate transformations are expressed as matrix multiplications:: a b 0 [ x′ y′ 1 ] = [ x y 1 ] Ă— c d 0 e f 1 Example: >>> from pypdf import Transformation >>> op = Transformation().scale(sx=2, sy=3).translate(tx=10, ty=20) >>> page.add_transformation(op) """ def __init__(self, ctm: CompressedTransformationMatrix = (1, 0, 0, 1, 0, 0)) -> None: self.ctm = ctm @property def matrix(self) -> TransformationMatrixType: """ Return the transformation matrix as a tuple of tuples in the form: ((a, b, 0), (c, d, 0), (e, f, 1)) """ return ( (self.ctm[0], self.ctm[1], 0), (self.ctm[2], self.ctm[3], 0), (self.ctm[4], self.ctm[5], 1), ) @staticmethod def compress(matrix: TransformationMatrixType) -> CompressedTransformationMatrix: """ Compresses the transformation matrix into a tuple of (a, b, c, d, e, f). Args: matrix: The transformation matrix as a tuple of tuples. Returns: A tuple representing the transformation matrix as (a, b, c, d, e, f) """ return ( matrix[0][0], matrix[0][1], matrix[1][0], matrix[1][1], matrix[2][0], matrix[2][1], ) def _to_cm(self) -> str: # Returns the cm operation string for the given transformation matrix return ( f"{self.ctm[0]:.4f} {self.ctm[1]:.4f} {self.ctm[2]:.4f} " f"{self.ctm[3]:.4f} {self.ctm[4]:.4f} {self.ctm[5]:.4f} cm" ) def transform(self, m: "Transformation") -> "Transformation": """ Apply one transformation to another. Args: m: a Transformation to apply. Returns: A new ``Transformation`` instance Example: >>> from pypdf import Transformation >>> op = Transformation((1, 0, 0, -1, 0, height)) # vertical mirror >>> op = Transformation().transform(Transformation((-1, 0, 0, 1, width, 0))) # horizontal mirror >>> page.add_transformation(op) """ ctm = Transformation.compress(matrix_multiply(self.matrix, m.matrix)) return Transformation(ctm) def translate(self, tx: float = 0, ty: float = 0) -> "Transformation": """ Translate the contents of a page. Args: tx: The translation along the x-axis. ty: The translation along the y-axis. Returns: A new ``Transformation`` instance """ m = self.ctm return Transformation(ctm=(m[0], m[1], m[2], m[3], m[4] + tx, m[5] + ty)) def scale( self, sx: Optional[float] = None, sy: Optional[float] = None ) -> "Transformation": """ Scale the contents of a page towards the origin of the coordinate system. Typically, that is the lower-left corner of the page. That can be changed by translating the contents / the page boxes. Args: sx: The scale factor along the x-axis. sy: The scale factor along the y-axis. Returns: A new Transformation instance with the scaled matrix. """ if sx is None and sy is None: raise ValueError("Either sx or sy must be specified") if sx is None: sx = sy if sy is None: sy = sx assert sx is not None assert sy is not None op: TransformationMatrixType = ((sx, 0, 0), (0, sy, 0), (0, 0, 1)) ctm = Transformation.compress(matrix_multiply(self.matrix, op)) return Transformation(ctm) def rotate(self, rotation: float) -> "Transformation": """ Rotate the contents of a page. Args: rotation: The angle of rotation in degrees. Returns: A new ``Transformation`` instance with the rotated matrix. """ rotation = math.radians(rotation) op: TransformationMatrixType = ( (math.cos(rotation), math.sin(rotation), 0), (-math.sin(rotation), math.cos(rotation), 0), (0, 0, 1), ) ctm = Transformation.compress(matrix_multiply(self.matrix, op)) return Transformation(ctm) def __repr__(self) -> str: return f"Transformation(ctm={self.ctm})" @overload def apply_on(self, pt: list[float], as_object: bool = False) -> list[float]: ... @overload def apply_on( self, pt: tuple[float, float], as_object: bool = False ) -> tuple[float, float]: ... def apply_on( self, pt: Union[tuple[float, float], list[float]], as_object: bool = False, ) -> Union[tuple[float, float], list[float]]: """ Apply the transformation matrix on the given point. Args: pt: A tuple or list representing the point in the form (x, y). as_object: If True, return items as FloatObject, otherwise as plain floats. Returns: A tuple or list representing the transformed point in the form (x', y') """ typ = FloatObject if as_object else float pt1 = ( typ(float(pt[0]) * self.ctm[0] + float(pt[1]) * self.ctm[2] + self.ctm[4]), typ(float(pt[0]) * self.ctm[1] + float(pt[1]) * self.ctm[3] + self.ctm[5]), ) return list(pt1) if isinstance(pt, list) else pt1 @dataclass class ImageFile: """ Image within the PDF file. *This object is not designed to be built.* This object should not be modified except using :func:`ImageFile.replace` to replace the image with a new one. """ name: str = "" """ Filename as identified within the PDF file. """ data: bytes = b"" """ Data as bytes. """ image: Optional[Image] = None """ Data as PIL image. """ indirect_reference: Optional[IndirectObject] = None """ Reference to the object storing the stream. """ def replace(self, new_image: Image, **kwargs: Any) -> None: """ Replace the image with a new PIL image. Args: new_image (PIL.Image.Image): The new PIL image to replace the existing image. **kwargs: Additional keyword arguments to pass to `Image.save()`. Raises: TypeError: If the image is inline or in a PdfReader. TypeError: If the image does not belong to a PdfWriter. TypeError: If `new_image` is not a PIL Image. Note: This method replaces the existing image with a new image. It is not allowed for inline images or images within a PdfReader. The `kwargs` parameter allows passing additional parameters to `Image.save()`, such as quality. """ if pil_not_imported: raise ImportError( "pillow is required to do image extraction. " "It can be installed via 'pip install pypdf[image]'" ) from ._reader import PdfReader # noqa: PLC0415 # to prevent circular import from .filters import _xobj_to_image # noqa: PLC0415 from .generic import DictionaryObject, PdfObject # noqa: PLC0415 if self.indirect_reference is None: raise TypeError("Cannot update an inline image.") if not hasattr(self.indirect_reference.pdf, "_id_translated"): raise TypeError("Cannot update an image not belonging to a PdfWriter.") if not isinstance(new_image, Image): raise TypeError("new_image shall be a PIL Image") b = BytesIO() new_image.save(b, "PDF", **kwargs) reader = PdfReader(b) assert reader.pages[0].images[0].indirect_reference is not None self.indirect_reference.pdf._objects[self.indirect_reference.idnum - 1] = ( reader.pages[0].images[0].indirect_reference.get_object() ) cast( PdfObject, self.indirect_reference.get_object() ).indirect_reference = self.indirect_reference # change the object attributes extension, byte_stream, img = _xobj_to_image( cast(DictionaryObject, self.indirect_reference.get_object()) ) assert extension is not None self.name = self.name[: self.name.rfind(".")] + extension self.data = byte_stream self.image = img def __str__(self) -> str: return f"{self.__class__.__name__}(name={self.name}, data: {_human_readable_bytes(len(self.data))})" def __repr__(self) -> str: return self.__str__()[:-1] + f", hash: {hash(self.data)})" class VirtualListImages(Sequence[ImageFile]): """ Provides access to images referenced within a page. Only one copy will be returned if the usage is used on the same page multiple times. See :func:`PageObject.images` for more details. """ def __init__( self, ids_function: Callable[[], list[Union[str, list[str]]]], get_function: Callable[[Union[str, list[str], tuple[str]]], ImageFile], ) -> None: self.ids_function = ids_function self.get_function = get_function self.current = -1 def __len__(self) -> int: return len(self.ids_function()) def keys(self) -> list[Union[str, list[str]]]: return self.ids_function() def items(self) -> list[tuple[Union[str, list[str]], ImageFile]]: return [(x, self[x]) for x in self.ids_function()] @overload def __getitem__(self, index: Union[int, str, list[str]]) -> ImageFile: ... @overload def __getitem__(self, index: slice) -> Sequence[ImageFile]: ... def __getitem__( self, index: Union[int, slice, str, list[str], tuple[str]] ) -> Union[ImageFile, Sequence[ImageFile]]: lst = self.ids_function() if isinstance(index, slice): indices = range(*index.indices(len(self))) lst = [lst[x] for x in indices] cls = type(self) return cls((lambda: lst), self.get_function) if isinstance(index, (str, list, tuple)): return self.get_function(index) if not isinstance(index, int): raise TypeError("Invalid sequence indices type") len_self = len(lst) if index < 0: # support negative indexes index += len_self if not (0 <= index < len_self): raise IndexError("Sequence index out of range") return self.get_function(lst[index]) def __iter__(self) -> Iterator[ImageFile]: for i in range(len(self)): yield self[i] def __str__(self) -> str: p = [f"Image_{i}={n}" for i, n in enumerate(self.ids_function())] return f"[{', '.join(p)}]" class PageObject(DictionaryObject): """ PageObject represents a single page within a PDF file. Typically these objects will be created by accessing the :attr:`pages` property of the :class:`PdfReader` class, but it is also possible to create an empty page with the :meth:`create_blank_page()` static method. Args: pdf: PDF file the page belongs to. indirect_reference: Stores the original indirect reference to this object in its source PDF """ original_page: "PageObject" # very local use in writer when appending def __init__( self, pdf: Optional[PdfCommonDocProtocol] = None, indirect_reference: Optional[IndirectObject] = None, ) -> None: DictionaryObject.__init__(self) self.pdf = pdf self.inline_images: Optional[dict[str, ImageFile]] = None self.indirect_reference = indirect_reference if not is_null_or_none(indirect_reference): assert indirect_reference is not None, "mypy" self.update(cast(DictionaryObject, indirect_reference.get_object())) self._font_width_maps: dict[str, tuple[dict[str, float], str, float]] = {} def hash_bin(self) -> int: """ Used to detect modified object. Note: this function is overloaded to return the same results as a DictionaryObject. Returns: Hash considering type and value. """ return hash( (DictionaryObject, tuple(((k, v.hash_bin()) for k, v in self.items()))) ) def hash_value_data(self) -> bytes: data = super().hash_value_data() data += f"{id(self)}".encode() return data @property def user_unit(self) -> float: """ A read-only positive number giving the size of user space units. It is in multiples of 1/72 inch. Hence a value of 1 means a user space unit is 1/72 inch, and a value of 3 means that a user space unit is 3/72 inch. """ return self.get(PG.USER_UNIT, 1) @staticmethod def create_blank_page( pdf: Optional[PdfCommonDocProtocol] = None, width: Union[float, Decimal, None] = None, height: Union[float, Decimal, None] = None, ) -> "PageObject": """ Return a new blank page. If ``width`` or ``height`` is ``None``, try to get the page size from the last page of *pdf*. Args: pdf: PDF file the page is within. width: The width of the new page expressed in default user space units. height: The height of the new page expressed in default user space units. Returns: The new blank page Raises: PageSizeNotDefinedError: if ``pdf`` is ``None`` or contains no page """ page = PageObject(pdf) # Creates a new page (cf PDF Reference §7.7.3.3) page.__setitem__(NameObject(PG.TYPE), NameObject("/Page")) page.__setitem__(NameObject(PG.PARENT), NullObject()) page.__setitem__(NameObject(PG.RESOURCES), DictionaryObject()) if width is None or height is None: if pdf is not None and len(pdf.pages) > 0: lastpage = pdf.pages[len(pdf.pages) - 1] width = lastpage.mediabox.width height = lastpage.mediabox.height else: raise PageSizeNotDefinedError page.__setitem__( NameObject(PG.MEDIABOX), RectangleObject((0, 0, width, height)) # type: ignore ) return page def _get_ids_image( self, obj: Optional[DictionaryObject] = None, ancest: Optional[list[str]] = None, call_stack: Optional[list[Any]] = None, ) -> list[Union[str, list[str]]]: if call_stack is None: call_stack = [] _i = getattr(obj, "indirect_reference", None) if _i in call_stack: return [] call_stack.append(_i) if self.inline_images is None: self.inline_images = self._get_inline_images() if obj is None: obj = self if ancest is None: ancest = [] lst: list[Union[str, list[str]]] = [] if ( PG.RESOURCES not in obj or is_null_or_none(resources := obj[PG.RESOURCES]) or RES.XOBJECT not in cast(DictionaryObject, resources) ): return [] if self.inline_images is None else list(self.inline_images.keys()) x_object = resources[RES.XOBJECT].get_object() # type: ignore for o in x_object: if not isinstance(x_object[o], StreamObject): continue if x_object[o][IA.SUBTYPE] == "/Image": lst.append(o if len(ancest) == 0 else [*ancest, o]) else: # is a form with possible images inside lst.extend(self._get_ids_image(x_object[o], [*ancest, o], call_stack)) assert self.inline_images is not None lst.extend(list(self.inline_images.keys())) return lst def _get_image( self, id: Union[str, list[str], tuple[str]], obj: Optional[DictionaryObject] = None, ) -> ImageFile: if obj is None: obj = cast(DictionaryObject, self) if isinstance(id, tuple): id = list(id) if isinstance(id, list) and len(id) == 1: id = id[0] try: xobjs = cast( DictionaryObject, cast(DictionaryObject, obj[PG.RESOURCES])[RES.XOBJECT] ) except KeyError: if not (id[0] == "~" and id[-1] == "~"): raise if isinstance(id, str): if id[0] == "~" and id[-1] == "~": if self.inline_images is None: self.inline_images = self._get_inline_images() if self.inline_images is None: # pragma: no cover raise KeyError("No inline image can be found") return self.inline_images[id] imgd = _xobj_to_image(cast(DictionaryObject, xobjs[id])) extension, byte_stream = imgd[:2] return ImageFile( name=f"{id[1:]}{extension}", data=byte_stream, image=imgd[2], indirect_reference=xobjs[id].indirect_reference, ) # in a subobject ids = id[1:] return self._get_image(ids, cast(DictionaryObject, xobjs[id[0]])) @property def images(self) -> VirtualListImages: """ Read-only property emulating a list of images on a page. Get a list of all images on the page. The key can be: - A string (for the top object) - A tuple (for images within XObject forms) - An integer Examples: * `reader.pages[0].images[0]` # return first image * `reader.pages[0].images['/I0']` # return image '/I0' * `reader.pages[0].images['/TP1','/Image1']` # return image '/Image1' within '/TP1' XObject form * `for img in reader.pages[0].images:` # loops through all objects images.keys() and images.items() can be used. The ImageFile has the following properties: * `.name` : name of the object * `.data` : bytes of the object * `.image` : PIL Image Object * `.indirect_reference` : object reference and the following methods: `.replace(new_image: PIL.Image.Image, **kwargs)` : replace the image in the pdf with the new image applying the saving parameters indicated (such as quality) Example usage: reader.pages[0].images[0].replace(Image.open("new_image.jpg"), quality=20) Inline images are extracted and named ~0~, ~1~, ..., with the indirect_reference set to None. """ return VirtualListImages(self._get_ids_image, self._get_image) def _translate_value_inline_image(self, k: str, v: PdfObject) -> PdfObject: """Translate values used in inline image""" try: v = NameObject(_INLINE_IMAGE_VALUE_MAPPING[cast(str, v)]) except (TypeError, KeyError): if isinstance(v, NameObject): # It is a custom name, thus we have to look in resources. # The only applicable case is for ColorSpace. try: res = cast(DictionaryObject, self["/Resources"])["/ColorSpace"] v = cast(DictionaryObject, res)[v] except KeyError: # for res and v raise PdfReadError(f"Cannot find resource entry {v} for {k}") return v def _get_inline_images(self) -> dict[str, ImageFile]: """Load inline images. Entries will be identified as `~1~`.""" content = self.get_contents() if is_null_or_none(content): return {} imgs_data = [] assert content is not None, "mypy" for param, ope in content.operations: if ope == b"INLINE IMAGE": imgs_data.append( {"settings": param["settings"], "__streamdata__": param["data"]} ) elif ope in (b"BI", b"EI", b"ID"): # pragma: no cover raise PdfReadError( f"{ope!r} operator met whereas not expected, " "please share use case with pypdf dev team" ) files = {} for num, ii in enumerate(imgs_data): init = { "__streamdata__": ii["__streamdata__"], "/Length": len(ii["__streamdata__"]), } for k, v in ii["settings"].items(): if k in {"/Length", "/L"}: # no length is expected continue if isinstance(v, list): v = ArrayObject( [self._translate_value_inline_image(k, x) for x in v] ) else: v = self._translate_value_inline_image(k, v) k = NameObject(_INLINE_IMAGE_KEY_MAPPING[k]) if k not in init: init[k] = v ii["object"] = EncodedStreamObject.initialize_from_dictionary(init) extension, byte_stream, img = _xobj_to_image(ii["object"]) files[f"~{num}~"] = ImageFile( name=f"~{num}~{extension}", data=byte_stream, image=img, indirect_reference=None, ) return files @property def rotation(self) -> int: """ The visual rotation of the page. This number has to be a multiple of 90 degrees: 0, 90, 180, or 270 are valid values. This property does not affect ``/Contents``. """ rotate_obj = self.get(PG.ROTATE, 0) return rotate_obj if isinstance(rotate_obj, int) else rotate_obj.get_object() @rotation.setter def rotation(self, r: float) -> None: self[NameObject(PG.ROTATE)] = NumberObject((((int(r) + 45) // 90) * 90) % 360) def transfer_rotation_to_content(self) -> None: """ Apply the rotation of the page to the content and the media/crop/... boxes. It is recommended to apply this function before page merging. """ r = -self.rotation # rotation to apply is in the otherway self.rotation = 0 mb = RectangleObject(self.mediabox) trsf = ( Transformation() .translate( -float(mb.left + mb.width / 2), -float(mb.bottom + mb.height / 2) ) .rotate(r) ) pt1 = trsf.apply_on(mb.lower_left) pt2 = trsf.apply_on(mb.upper_right) trsf = trsf.translate(-min(pt1[0], pt2[0]), -min(pt1[1], pt2[1])) self.add_transformation(trsf, False) for b in ["/MediaBox", "/CropBox", "/BleedBox", "/TrimBox", "/ArtBox"]: if b in self: rr = RectangleObject(self[b]) # type: ignore pt1 = trsf.apply_on(rr.lower_left) pt2 = trsf.apply_on(rr.upper_right) self[NameObject(b)] = RectangleObject( ( min(pt1[0], pt2[0]), min(pt1[1], pt2[1]), max(pt1[0], pt2[0]), max(pt1[1], pt2[1]), ) ) def rotate(self, angle: int) -> "PageObject": """ Rotate a page clockwise by increments of 90 degrees. Args: angle: Angle to rotate the page. Must be an increment of 90 deg. Returns: The rotated PageObject """ if angle % 90 != 0: raise ValueError("Rotation angle must be a multiple of 90") self[NameObject(PG.ROTATE)] = NumberObject(self.rotation + angle) return self def _merge_resources( self, res1: DictionaryObject, res2: DictionaryObject, resource: Any, new_res1: bool = True, ) -> tuple[dict[str, Any], dict[str, Any]]: try: assert isinstance(self.indirect_reference, IndirectObject) pdf = self.indirect_reference.pdf is_pdf_writer = hasattr( pdf, "_add_object" ) # expect isinstance(pdf, PdfWriter) except (AssertionError, AttributeError): pdf = None is_pdf_writer = False def compute_unique_key(base_key: str) -> tuple[str, bool]: """ Find a key that either doesn't already exist or has the same value (indicated by the bool) Args: base_key: An index is added to this to get the computed key Returns: A tuple (computed key, bool) where the boolean indicates if there is a resource of the given computed_key with the same value. """ value = page2res.raw_get(base_key) # TODO: a possible improvement for writer, the indirect_reference # cannot be found because translated # try the current key first (e.g. "foo"), but otherwise iterate # through "foo-0", "foo-1", etc. new_res can contain only finitely # many keys, thus this'll eventually end, even if it's been crafted # to be maximally annoying. computed_key = base_key idx = 0 while computed_key in new_res: if new_res.raw_get(computed_key) == value: # there's already a resource of this name, with the exact # same value return computed_key, True computed_key = f"{base_key}-{idx}" idx += 1 return computed_key, False if new_res1: new_res = DictionaryObject() new_res.update(res1.get(resource, DictionaryObject()).get_object()) else: new_res = cast(DictionaryObject, res1[resource]) page2res = cast( DictionaryObject, res2.get(resource, DictionaryObject()).get_object() ) rename_res = {} for key in page2res: unique_key, same_value = compute_unique_key(key) newname = NameObject(unique_key) if key != unique_key: # we have to use a different name for this rename_res[key] = newname if not same_value: if is_pdf_writer: new_res[newname] = page2res.raw_get(key).clone(pdf) try: new_res[newname] = new_res[newname].indirect_reference except AttributeError: pass else: new_res[newname] = page2res.raw_get(key) lst = sorted(new_res.items()) new_res.clear() for el in lst: new_res[el[0]] = el[1] return new_res, rename_res @staticmethod def _content_stream_rename( stream: ContentStream, rename: dict[Any, Any], pdf: Optional[PdfCommonDocProtocol], ) -> ContentStream: if not rename: return stream stream = ContentStream(stream, pdf) for operands, _operator in stream.operations: if isinstance(operands, list): for i, op in enumerate(operands): if isinstance(op, NameObject): operands[i] = rename.get(op, op) elif isinstance(operands, dict): for i, op in operands.items(): if isinstance(op, NameObject): operands[i] = rename.get(op, op) else: raise KeyError(f"Type of operands is {type(operands)}") return stream @staticmethod def _add_transformation_matrix( contents: Any, pdf: Optional[PdfCommonDocProtocol], ctm: CompressedTransformationMatrix, ) -> ContentStream: """Add transformation matrix at the beginning of the given contents stream.""" contents = ContentStream(contents, pdf) contents.operations.insert( 0, [ [FloatObject(x) for x in ctm], b"cm", ], ) return contents def _get_contents_as_bytes(self) -> Optional[bytes]: """ Return the page contents as bytes. Returns: The ``/Contents`` object as bytes, or ``None`` if it doesn't exist. """ if PG.CONTENTS in self: obj = self[PG.CONTENTS].get_object() if isinstance(obj, list): return b"".join(x.get_object().get_data() for x in obj) return cast(EncodedStreamObject, obj).get_data() return None def get_contents(self) -> Optional[ContentStream]: """ Access the page contents. Returns: The ``/Contents`` object, or ``None`` if it does not exist. ``/Contents`` is optional, as described in §7.7.3.3 of the PDF Reference. """ if PG.CONTENTS in self: try: pdf = cast(IndirectObject, self.indirect_reference).pdf except AttributeError: pdf = None obj = self[PG.CONTENTS] if is_null_or_none(obj): return None resolved_object = obj.get_object() return ContentStream(resolved_object, pdf) return None def replace_contents( self, content: Union[None, ContentStream, EncodedStreamObject, ArrayObject] ) -> None: """ Replace the page contents with the new content and nullify old objects Args: content: new content; if None delete the content field. """ if not hasattr(self, "indirect_reference") or self.indirect_reference is None: # the page is not attached : the content is directly attached. self[NameObject(PG.CONTENTS)] = content return if isinstance(self.get(PG.CONTENTS, None), ArrayObject): for o in self[PG.CONTENTS]: # type: ignore[attr-defined] try: self._objects[o.indirect_reference.idnum - 1] = NullObject() # type: ignore except AttributeError: pass if isinstance(content, ArrayObject): content = ArrayObject(self.indirect_reference.pdf._add_object(obj) for obj in content) if is_null_or_none(content): if PG.CONTENTS not in self: return assert self.indirect_reference is not None assert self[PG.CONTENTS].indirect_reference is not None self.indirect_reference.pdf._objects[ self[PG.CONTENTS].indirect_reference.idnum - 1 # type: ignore ] = NullObject() del self[PG.CONTENTS] elif not hasattr(self.get(PG.CONTENTS, None), "indirect_reference"): try: self[NameObject(PG.CONTENTS)] = self.indirect_reference.pdf._add_object( content ) except AttributeError: # applies at least for page not in writer # as a backup solution, we put content as an object although not in accordance with pdf ref # this will be fixed with the _add_object self[NameObject(PG.CONTENTS)] = content else: assert content is not None, "mypy" content.indirect_reference = self[ PG.CONTENTS ].indirect_reference # TODO: in the future may require generation management try: self.indirect_reference.pdf._objects[ content.indirect_reference.idnum - 1 # type: ignore ] = content except AttributeError: # applies at least for page not in writer # as a backup solution, we put content as an object although not in accordance with pdf ref # this will be fixed with the _add_object self[NameObject(PG.CONTENTS)] = content # forces recalculation of inline_images self.inline_images = None def merge_page( self, page2: "PageObject", expand: bool = False, over: bool = True ) -> None: """ Merge the content streams of two pages into one. Resource references (e.g. fonts) are maintained from both pages. The mediabox, cropbox, etc of this page are not altered. The parameter page's content stream will be added to the end of this page's content stream, meaning that it will be drawn after, or "on top" of this page. Args: page2: The page to be merged into this one. Should be an instance of :class:`PageObject`. over: set the page2 content over page1 if True (default) else under expand: If True, the current page dimensions will be expanded to accommodate the dimensions of the page to be merged. """ self._merge_page(page2, over=over, expand=expand) def _merge_page( self, page2: "PageObject", page2transformation: Optional[Callable[[Any], ContentStream]] = None, ctm: Optional[CompressedTransformationMatrix] = None, over: bool = True, expand: bool = False, ) -> None: # First we work on merging the resource dictionaries. This allows us # to find out what symbols in the content streams we might need to # rename. try: assert isinstance(self.indirect_reference, IndirectObject) if hasattr( self.indirect_reference.pdf, "_add_object" ): # to detect PdfWriter return self._merge_page_writer( page2, page2transformation, ctm, over, expand ) except (AssertionError, AttributeError): pass new_resources = DictionaryObject() rename = {} try: original_resources = cast(DictionaryObject, self[PG.RESOURCES].get_object()) except KeyError: original_resources = DictionaryObject() try: page2resources = cast(DictionaryObject, page2[PG.RESOURCES].get_object()) except KeyError: page2resources = DictionaryObject() new_annots = ArrayObject() for page in (self, page2): if PG.ANNOTS in page: annots = page[PG.ANNOTS] if isinstance(annots, ArrayObject): new_annots.extend(annots) for res in ( RES.EXT_G_STATE, RES.FONT, RES.XOBJECT, RES.COLOR_SPACE, RES.PATTERN, RES.SHADING, RES.PROPERTIES, ): new, newrename = self._merge_resources( original_resources, page2resources, res ) if new: new_resources[NameObject(res)] = new rename.update(newrename) # Combine /ProcSet sets, making sure there's a consistent order new_resources[NameObject(RES.PROC_SET)] = ArrayObject( sorted( set( original_resources.get(RES.PROC_SET, ArrayObject()).get_object() ).union( set(page2resources.get(RES.PROC_SET, ArrayObject()).get_object()) ) ) ) new_content_array = ArrayObject() original_content = self.get_contents() if original_content is not None: original_content.isolate_graphics_state() new_content_array.append(original_content) page2content = page2.get_contents() if page2content is not None: rect = getattr(page2, MERGE_CROP_BOX) page2content.operations.insert( 0, ( map( FloatObject, [ rect.left, rect.bottom, rect.width, rect.height, ], ), b"re", ), ) page2content.operations.insert(1, ([], b"W")) page2content.operations.insert(2, ([], b"n")) if page2transformation is not None: page2content = page2transformation(page2content) page2content = PageObject._content_stream_rename( page2content, rename, self.pdf ) page2content.isolate_graphics_state() if over: new_content_array.append(page2content) else: new_content_array.insert(0, page2content) # if expanding the page to fit a new page, calculate the new media box size if expand: self._expand_mediabox(page2, ctm) self.replace_contents(ContentStream(new_content_array, self.pdf)) self[NameObject(PG.RESOURCES)] = new_resources self[NameObject(PG.ANNOTS)] = new_annots def _merge_page_writer( self, page2: "PageObject", page2transformation: Optional[Callable[[Any], ContentStream]] = None, ctm: Optional[CompressedTransformationMatrix] = None, over: bool = True, expand: bool = False, ) -> None: # First we work on merging the resource dictionaries. This allows us # to find which symbols in the content streams we might need to # rename. assert isinstance(self.indirect_reference, IndirectObject) pdf = self.indirect_reference.pdf rename = {} if PG.RESOURCES not in self: self[NameObject(PG.RESOURCES)] = DictionaryObject() original_resources = cast(DictionaryObject, self[PG.RESOURCES].get_object()) if PG.RESOURCES not in page2: page2resources = DictionaryObject() else: page2resources = cast(DictionaryObject, page2[PG.RESOURCES].get_object()) for res in ( RES.EXT_G_STATE, RES.FONT, RES.XOBJECT, RES.COLOR_SPACE, RES.PATTERN, RES.SHADING, RES.PROPERTIES, ): if res in page2resources: if res not in original_resources: original_resources[NameObject(res)] = DictionaryObject() _, newrename = self._merge_resources( original_resources, page2resources, res, False ) rename.update(newrename) # Combine /ProcSet sets. if RES.PROC_SET in page2resources: if RES.PROC_SET not in original_resources: original_resources[NameObject(RES.PROC_SET)] = ArrayObject() arr = cast(ArrayObject, original_resources[RES.PROC_SET]) for x in cast(ArrayObject, page2resources[RES.PROC_SET]): if x not in arr: arr.append(x) arr.sort() if PG.ANNOTS in page2: if PG.ANNOTS not in self: self[NameObject(PG.ANNOTS)] = ArrayObject() annots = cast(ArrayObject, self[PG.ANNOTS].get_object()) if ctm is None: trsf = Transformation() else: trsf = Transformation(ctm) for a in cast(ArrayObject, page2[PG.ANNOTS]): a = a.get_object() aa = a.clone( pdf, ignore_fields=("/P", "/StructParent", "/Parent"), force_duplicate=True, ) r = cast(ArrayObject, a["/Rect"]) pt1 = trsf.apply_on((r[0], r[1]), True) pt2 = trsf.apply_on((r[2], r[3]), True) aa[NameObject("/Rect")] = ArrayObject( ( min(pt1[0], pt2[0]), min(pt1[1], pt2[1]), max(pt1[0], pt2[0]), max(pt1[1], pt2[1]), ) ) if "/QuadPoints" in a: q = cast(ArrayObject, a["/QuadPoints"]) aa[NameObject("/QuadPoints")] = ArrayObject( trsf.apply_on((q[0], q[1]), True) + trsf.apply_on((q[2], q[3]), True) + trsf.apply_on((q[4], q[5]), True) + trsf.apply_on((q[6], q[7]), True) ) try: aa["/Popup"][NameObject("/Parent")] = aa.indirect_reference except KeyError: pass try: aa[NameObject("/P")] = self.indirect_reference annots.append(aa.indirect_reference) except AttributeError: pass new_content_array = ArrayObject() original_content = self.get_contents() if original_content is not None: original_content.isolate_graphics_state() new_content_array.append(original_content) page2content = page2.get_contents() if page2content is not None: rect = getattr(page2, MERGE_CROP_BOX) page2content.operations.insert( 0, ( map( FloatObject, [ rect.left, rect.bottom, rect.width, rect.height, ], ), b"re", ), ) page2content.operations.insert(1, ([], b"W")) page2content.operations.insert(2, ([], b"n")) if page2transformation is not None: page2content = page2transformation(page2content) page2content = PageObject._content_stream_rename( page2content, rename, self.pdf ) page2content.isolate_graphics_state() if over: new_content_array.append(page2content) else: new_content_array.insert(0, page2content) # if expanding the page to fit a new page, calculate the new media box size if expand: self._expand_mediabox(page2, ctm) self.replace_contents(new_content_array) def _expand_mediabox( self, page2: "PageObject", ctm: Optional[CompressedTransformationMatrix] ) -> None: corners1 = ( self.mediabox.left.as_numeric(), self.mediabox.bottom.as_numeric(), self.mediabox.right.as_numeric(), self.mediabox.top.as_numeric(), ) corners2 = ( page2.mediabox.left.as_numeric(), page2.mediabox.bottom.as_numeric(), page2.mediabox.left.as_numeric(), page2.mediabox.top.as_numeric(), page2.mediabox.right.as_numeric(), page2.mediabox.top.as_numeric(), page2.mediabox.right.as_numeric(), page2.mediabox.bottom.as_numeric(), ) if ctm is not None: ctm = tuple(float(x) for x in ctm) # type: ignore[assignment] new_x = tuple( ctm[0] * corners2[i] + ctm[2] * corners2[i + 1] + ctm[4] for i in range(0, 8, 2) ) new_y = tuple( ctm[1] * corners2[i] + ctm[3] * corners2[i + 1] + ctm[5] for i in range(0, 8, 2) ) else: new_x = corners2[0:8:2] new_y = corners2[1:8:2] lowerleft = (min(new_x), min(new_y)) upperright = (max(new_x), max(new_y)) lowerleft = (min(corners1[0], lowerleft[0]), min(corners1[1], lowerleft[1])) upperright = ( max(corners1[2], upperright[0]), max(corners1[3], upperright[1]), ) self.mediabox.lower_left = lowerleft self.mediabox.upper_right = upperright def merge_transformed_page( self, page2: "PageObject", ctm: Union[CompressedTransformationMatrix, Transformation], over: bool = True, expand: bool = False, ) -> None: """ Similar to :meth:`~pypdf._page.PageObject.merge_page`, but a transformation matrix is applied to the merged stream. Args: page2: The page to be merged into this one. ctm: a 6-element tuple containing the operands of the transformation matrix over: set the page2 content over page1 if True (default) else under expand: Whether the page should be expanded to fit the dimensions of the page to be merged. """ if isinstance(ctm, Transformation): ctm = ctm.ctm self._merge_page( page2, lambda page2Content: PageObject._add_transformation_matrix( page2Content, page2.pdf, ctm ), ctm, over, expand, ) def merge_scaled_page( self, page2: "PageObject", scale: float, over: bool = True, expand: bool = False ) -> None: """ Similar to :meth:`~pypdf._page.PageObject.merge_page`, but the stream to be merged is scaled by applying a transformation matrix. Args: page2: The page to be merged into this one. scale: The scaling factor over: set the page2 content over page1 if True (default) else under expand: Whether the page should be expanded to fit the dimensions of the page to be merged. """ op = Transformation().scale(scale, scale) self.merge_transformed_page(page2, op, over, expand) def merge_rotated_page( self, page2: "PageObject", rotation: float, over: bool = True, expand: bool = False, ) -> None: """ Similar to :meth:`~pypdf._page.PageObject.merge_page`, but the stream to be merged is rotated by applying a transformation matrix. Args: page2: The page to be merged into this one. rotation: The angle of the rotation, in degrees over: set the page2 content over page1 if True (default) else under expand: Whether the page should be expanded to fit the dimensions of the page to be merged. """ op = Transformation().rotate(rotation) self.merge_transformed_page(page2, op, over, expand) def merge_translated_page( self, page2: "PageObject", tx: float, ty: float, over: bool = True, expand: bool = False, ) -> None: """ Similar to :meth:`~pypdf._page.PageObject.merge_page`, but the stream to be merged is translated by applying a transformation matrix. Args: page2: the page to be merged into this one. tx: The translation on X axis ty: The translation on Y axis over: set the page2 content over page1 if True (default) else under expand: Whether the page should be expanded to fit the dimensions of the page to be merged. """ op = Transformation().translate(tx, ty) self.merge_transformed_page(page2, op, over, expand) def add_transformation( self, ctm: Union[Transformation, CompressedTransformationMatrix], expand: bool = False, ) -> None: """ Apply a transformation matrix to the page. Args: ctm: A 6-element tuple containing the operands of the transformation matrix. Alternatively, a :py:class:`Transformation` object can be passed. See :doc:`/user/cropping-and-transforming`. """ if isinstance(ctm, Transformation): ctm = ctm.ctm content = self.get_contents() if content is not None: content = PageObject._add_transformation_matrix(content, self.pdf, ctm) content.isolate_graphics_state() self.replace_contents(content) # if expanding the page to fit a new page, calculate the new media box size if expand: corners = [ self.mediabox.left.as_numeric(), self.mediabox.bottom.as_numeric(), self.mediabox.left.as_numeric(), self.mediabox.top.as_numeric(), self.mediabox.right.as_numeric(), self.mediabox.top.as_numeric(), self.mediabox.right.as_numeric(), self.mediabox.bottom.as_numeric(), ] ctm = tuple(float(x) for x in ctm) # type: ignore[assignment] new_x = [ ctm[0] * corners[i] + ctm[2] * corners[i + 1] + ctm[4] for i in range(0, 8, 2) ] new_y = [ ctm[1] * corners[i] + ctm[3] * corners[i + 1] + ctm[5] for i in range(0, 8, 2) ] self.mediabox.lower_left = (min(new_x), min(new_y)) self.mediabox.upper_right = (max(new_x), max(new_y)) def scale(self, sx: float, sy: float) -> None: """ Scale a page by the given factors by applying a transformation matrix to its content and updating the page size. This updates the various page boundaries (mediabox, cropbox, etc.) and the contents of the page. Args: sx: The scaling factor on horizontal axis. sy: The scaling factor on vertical axis. """ self.add_transformation((sx, 0, 0, sy, 0, 0)) self.mediabox = self.mediabox.scale(sx, sy) self.cropbox = self.cropbox.scale(sx, sy) self.bleedbox = self.bleedbox.scale(sx, sy) self.trimbox = self.trimbox.scale(sx, sy) self.artbox = self.artbox.scale(sx, sy) if PG.ANNOTS in self: annotations = self[PG.ANNOTS] if isinstance(annotations, ArrayObject): for annotation in annotations: annotation_obj = annotation.get_object() if ADA.Rect in annotation_obj: rectangle = annotation_obj[ADA.Rect] if isinstance(rectangle, ArrayObject): rectangle[0] = FloatObject(float(rectangle[0]) * sx) rectangle[1] = FloatObject(float(rectangle[1]) * sy) rectangle[2] = FloatObject(float(rectangle[2]) * sx) rectangle[3] = FloatObject(float(rectangle[3]) * sy) if PG.VP in self: viewport = self[PG.VP] if isinstance(viewport, ArrayObject): bbox = viewport[0]["/BBox"] else: bbox = viewport["/BBox"] # type: ignore scaled_bbox = RectangleObject( ( float(bbox[0]) * sx, float(bbox[1]) * sy, float(bbox[2]) * sx, float(bbox[3]) * sy, ) ) if isinstance(viewport, ArrayObject): self[NameObject(PG.VP)][NumberObject(0)][ # type: ignore NameObject("/BBox") ] = scaled_bbox else: self[NameObject(PG.VP)][NameObject("/BBox")] = scaled_bbox # type: ignore def scale_by(self, factor: float) -> None: """ Scale a page by the given factor by applying a transformation matrix to its content and updating the page size. Args: factor: The scaling factor (for both X and Y axis). """ self.scale(factor, factor) def scale_to(self, width: float, height: float) -> None: """ Scale a page to the specified dimensions by applying a transformation matrix to its content and updating the page size. Args: width: The new width. height: The new height. """ sx = width / float(self.mediabox.width) sy = height / float(self.mediabox.height) self.scale(sx, sy) def compress_content_streams(self, level: int = -1) -> None: """ Compress the size of this page by joining all content streams and applying a FlateDecode filter. However, it is possible that this function will perform no action if content stream compression becomes "automatic". """ content = self.get_contents() if content is not None: content_obj = content.flate_encode(level) try: content.indirect_reference.pdf._objects[ # type: ignore content.indirect_reference.idnum - 1 # type: ignore ] = content_obj except AttributeError: if self.indirect_reference is not None and hasattr( self.indirect_reference.pdf, "_add_object" ): self.replace_contents(content_obj) else: raise ValueError("Page must be part of a PdfWriter") @property def page_number(self) -> Optional[int]: """ Read-only property which returns the page number within the PDF file. Returns: Page number; None if the page is not attached to a PDF. """ if self.indirect_reference is None: return None try: lst = self.indirect_reference.pdf.pages return lst.index(self) except ValueError: return None def _debug_for_extract(self) -> str: # pragma: no cover out = "" for ope, op in ContentStream( self["/Contents"].get_object(), self.pdf, "bytes" ).operations: if op == b"TJ": s = [x for x in ope[0] if isinstance(x, str)] else: s = [] out += op.decode("utf-8") + " " + "".join(s) + ope.__repr__() + "\n" out += "\n=============================\n" try: for fo in self[PG.RESOURCES]["/Font"]: # type:ignore out += fo + "\n" out += self[PG.RESOURCES]["/Font"][fo].__repr__() + "\n" # type:ignore try: enc_repr = self[PG.RESOURCES]["/Font"][fo][ # type:ignore "/Encoding" ].__repr__() out += enc_repr + "\n" except Exception: pass try: out += ( self[PG.RESOURCES]["/Font"][fo][ # type:ignore "/ToUnicode" ] .get_data() .decode() + "\n" ) except Exception: pass except KeyError: out += "No Font\n" return out def _extract_text( self, obj: Any, pdf: Any, orientations: tuple[int, ...] = (0, 90, 180, 270), space_width: float = 200.0, content_key: Optional[str] = PG.CONTENTS, visitor_operand_before: Optional[Callable[[Any, Any, Any, Any], None]] = None, visitor_operand_after: Optional[Callable[[Any, Any, Any, Any], None]] = None, visitor_text: Optional[Callable[[Any, Any, Any, Any, Any], None]] = None, ) -> str: """ See extract_text for most arguments. Args: content_key: indicate the default key where to extract data None = the object; this allows reusing the function on an XObject default = "/Content" """ extractor = TextExtraction() cmaps: dict[ str, tuple[ str, float, Union[str, dict[int, str]], dict[str, str], DictionaryObject ], ] = {} try: objr = obj while NameObject(PG.RESOURCES) not in objr: # /Resources can be inherited so we look to parents objr = objr["/Parent"].get_object() # If no parents then no /Resources will be available, # so an exception will be raised resources_dict = cast(DictionaryObject, objr[PG.RESOURCES]) except Exception: # No resources means no text is possible (no font); we consider the # file as not damaged, no need to check for TJ or Tj return "" if not is_null_or_none(resources_dict) and "/Font" in resources_dict and (font := resources_dict["/Font"]): for f in cast(DictionaryObject, font): try: cmaps[f] = build_char_map(f, space_width, obj) except TypeError: pass try: content = ( obj[content_key].get_object() if isinstance(content_key, str) else obj ) if not isinstance(content, ContentStream): content = ContentStream(content, pdf, "bytes") except (AttributeError, KeyError): # no content can be extracted (certainly empty page) return "" # We check all strings are TextStringObjects. ByteStringObjects # are strings where the byte->string encoding was unknown, so adding # them to the text here would be gibberish. # Initialize the extractor with the necessary parameters extractor.initialize_extraction(orientations, visitor_text, cmaps) for operands, operator in content.operations: if visitor_operand_before is not None: visitor_operand_before(operator, operands, extractor.cm_matrix, extractor.tm_matrix) # Multiple operators are handled here if operator == b"'": extractor.process_operation(b"T*", []) extractor.process_operation(b"Tj", operands) elif operator == b'"': extractor.process_operation(b"Tw", [operands[0]]) extractor.process_operation(b"Tc", [operands[1]]) extractor.process_operation(b"T*", []) extractor.process_operation(b"Tj", operands[2:]) elif operator == b"TJ": # The space width may be smaller than the font width, so the width should be 95%. _confirm_space_width = extractor._space_width * 0.95 if operands: for op in operands[0]: if isinstance(op, (str, bytes)): extractor.process_operation(b"Tj", [op]) if isinstance(op, (int, float, NumberObject, FloatObject)) and ( abs(float(op)) >= _confirm_space_width and extractor.text and extractor.text[-1] != " " ): extractor.process_operation(b"Tj", [" "]) elif operator == b"TD": extractor.process_operation(b"TL", [-operands[1]]) extractor.process_operation(b"Td", operands) elif operator == b"Do": extractor.output += extractor.text if visitor_text is not None: visitor_text( extractor.text, extractor.memo_cm, extractor.memo_tm, extractor.cmap[3], extractor.font_size, ) try: if extractor.output[-1] != "\n": extractor.output += "\n" if visitor_text is not None: visitor_text( "\n", extractor.memo_cm, extractor.memo_tm, extractor.cmap[3], extractor.font_size, ) except IndexError: pass try: xobj = resources_dict["/XObject"] if xobj[operands[0]]["/Subtype"] != "/Image": # type: ignore text = self.extract_xform_text( xobj[operands[0]], # type: ignore orientations, space_width, visitor_operand_before, visitor_operand_after, visitor_text, ) extractor.output += text if visitor_text is not None: visitor_text( text, extractor.memo_cm, extractor.memo_tm, extractor.cmap[3], extractor.font_size, ) except Exception as exception: logger_warning( f"Impossible to decode XFormObject {operands[0]}: {exception}", __name__, ) finally: extractor.text = "" extractor.memo_cm = extractor.cm_matrix.copy() extractor.memo_tm = extractor.tm_matrix.copy() else: extractor.process_operation(operator, operands) if visitor_operand_after is not None: visitor_operand_after(operator, operands, extractor.cm_matrix, extractor.tm_matrix) extractor.output += extractor.text # just in case if extractor.text != "" and visitor_text is not None: visitor_text( extractor.text, extractor.memo_cm, extractor.memo_tm, extractor.cmap[3], extractor.font_size, ) return extractor.output def _layout_mode_fonts(self) -> dict[str, _layout_mode.Font]: """ Get fonts formatted for "layout" mode text extraction. Returns: Dict[str, Font]: dictionary of _layout_mode.Font instances keyed by font name """ # Font retrieval logic adapted from pypdf.PageObject._extract_text() objr: Any = self fonts: dict[str, _layout_mode.Font] = {} while objr is not None: try: resources_dict: Any = objr[PG.RESOURCES] except KeyError: resources_dict = {} if "/Font" in resources_dict and self.pdf is not None: for font_name in resources_dict["/Font"]: *cmap, font_dict_obj = build_char_map(font_name, 200.0, self) font_dict = { k: v.get_object() if isinstance(v, IndirectObject) else [_v.get_object() for _v in v] if isinstance(v, ArrayObject) else v for k, v in font_dict_obj.items() } # mypy really sucks at unpacking fonts[font_name] = _layout_mode.Font(*cmap, font_dict) # type: ignore[call-arg,arg-type] try: objr = objr["/Parent"].get_object() except KeyError: objr = None return fonts def _layout_mode_text( self, space_vertically: bool = True, scale_weight: float = 1.25, strip_rotated: bool = True, debug_path: Optional[Path] = None, font_height_weight: float = 1, ) -> str: """ Get text preserving fidelity to source PDF text layout. Args: space_vertically: include blank lines inferred from y distance + font height. Defaults to True. scale_weight: multiplier for string length when calculating weighted average character width. Defaults to 1.25. strip_rotated: Removes text that is rotated w.r.t. to the page from layout mode output. Defaults to True. debug_path (Path | None): if supplied, must target a directory. creates the following files with debug information for layout mode functions if supplied: - fonts.json: output of self._layout_mode_fonts - tjs.json: individual text render ops with corresponding transform matrices - bts.json: text render ops left justified and grouped by BT/ET operators - bt_groups.json: BT/ET operations grouped by rendered y-coord (aka lines) Defaults to None. font_height_weight: multiplier for font height when calculating blank lines. Defaults to 1. Returns: str: multiline string containing page text in a fixed width format that closely adheres to the rendered layout in the source pdf. """ fonts = self._layout_mode_fonts() if debug_path: # pragma: no cover import json # noqa: PLC0415 debug_path.joinpath("fonts.json").write_text( json.dumps( fonts, indent=2, default=lambda x: getattr(x, "to_dict", str)(x) ), "utf-8", ) ops = iter( ContentStream(self["/Contents"].get_object(), self.pdf, "bytes").operations ) bt_groups = _layout_mode.text_show_operations( ops, fonts, strip_rotated, debug_path ) if not bt_groups: return "" ty_groups = _layout_mode.y_coordinate_groups(bt_groups, debug_path) char_width = _layout_mode.fixed_char_width(bt_groups, scale_weight) return _layout_mode.fixed_width_page(ty_groups, char_width, space_vertically, font_height_weight) def extract_text( self, *args: Any, orientations: Union[int, tuple[int, ...]] = (0, 90, 180, 270), space_width: float = 200.0, visitor_operand_before: Optional[Callable[[Any, Any, Any, Any], None]] = None, visitor_operand_after: Optional[Callable[[Any, Any, Any, Any], None]] = None, visitor_text: Optional[Callable[[Any, Any, Any, Any, Any], None]] = None, extraction_mode: Literal["plain", "layout"] = "plain", **kwargs: Any, ) -> str: """ Locate all text drawing commands, in the order they are provided in the content stream, and extract the text. This works well for some PDF files, but poorly for others, depending on the generator used. This will be refined in the future. Do not rely on the order of text coming out of this function, as it will change if this function is made more sophisticated. Arabic and Hebrew are extracted in the correct order. If required a custom RTL range of characters can be defined; see function set_custom_rtl. Additionally you can provide visitor methods to get informed on all operations and all text objects. For example in some PDF files this can be useful to parse tables. Args: orientations: list of orientations extract_text will look for default = (0, 90, 180, 270) note: currently only 0 (up),90 (turned left), 180 (upside down), 270 (turned right) Silently ignored in "layout" mode. space_width: force default space width if not extracted from font (default: 200) Silently ignored in "layout" mode. visitor_operand_before: function to be called before processing an operation. It has four arguments: operator, operand-arguments, current transformation matrix and text matrix. Ignored with a warning in "layout" mode. visitor_operand_after: function to be called after processing an operation. It has four arguments: operator, operand-arguments, current transformation matrix and text matrix. Ignored with a warning in "layout" mode. visitor_text: function to be called when extracting some text at some position. It has five arguments: text, current transformation matrix, text matrix, font-dictionary and font-size. The font-dictionary may be None in case of unknown fonts. If not None it may e.g. contain key "/BaseFont" with value "/Arial,Bold". Ignored with a warning in "layout" mode. extraction_mode (Literal["plain", "layout"]): "plain" for legacy functionality, "layout" for experimental layout mode functionality. NOTE: orientations, space_width, and visitor_* parameters are NOT respected in "layout" mode. kwargs: layout_mode_space_vertically (bool): include blank lines inferred from y distance + font height. Defaults to True. layout_mode_scale_weight (float): multiplier for string length when calculating weighted average character width. Defaults to 1.25. layout_mode_strip_rotated (bool): layout mode does not support rotated text. Set to False to include rotated text anyway. If rotated text is discovered, layout will be degraded and a warning will result. Defaults to True. layout_mode_debug_path (Path | None): if supplied, must target a directory. creates the following files with debug information for layout mode functions if supplied: - fonts.json: output of self._layout_mode_fonts - tjs.json: individual text render ops with corresponding transform matrices - bts.json: text render ops left justified and grouped by BT/ET operators - bt_groups.json: BT/ET operations grouped by rendered y-coord (aka lines) layout_mode_font_height_weight (float): multiplier for font height when calculating blank lines. Defaults to 1. Returns: The extracted text """ if extraction_mode not in ["plain", "layout"]: raise ValueError(f"Invalid text extraction mode '{extraction_mode}'") if extraction_mode == "layout": for visitor in ( "visitor_operand_before", "visitor_operand_after", "visitor_text", ): if locals()[visitor]: logger_warning( f"Argument {visitor} is ignored in layout mode", __name__, ) return self._layout_mode_text( space_vertically=kwargs.get("layout_mode_space_vertically", True), scale_weight=kwargs.get("layout_mode_scale_weight", 1.25), strip_rotated=kwargs.get("layout_mode_strip_rotated", True), debug_path=kwargs.get("layout_mode_debug_path"), font_height_weight=kwargs.get("layout_mode_font_height_weight", 1) ) if len(args) >= 1: if isinstance(args[0], str): if len(args) >= 3: if isinstance(args[2], (tuple, int)): orientations = args[2] else: raise TypeError(f"Invalid positional parameter {args[2]}") if len(args) >= 4: if isinstance(args[3], (float, int)): space_width = args[3] else: raise TypeError(f"Invalid positional parameter {args[3]}") elif isinstance(args[0], (tuple, int)): orientations = args[0] if len(args) >= 2: if isinstance(args[1], (float, int)): space_width = args[1] else: raise TypeError(f"Invalid positional parameter {args[1]}") else: raise TypeError(f"Invalid positional parameter {args[0]}") if isinstance(orientations, int): orientations = (orientations,) return self._extract_text( self, self.pdf, orientations, space_width, PG.CONTENTS, visitor_operand_before, visitor_operand_after, visitor_text, ) def extract_xform_text( self, xform: EncodedStreamObject, orientations: tuple[int, ...] = (0, 90, 270, 360), space_width: float = 200.0, visitor_operand_before: Optional[Callable[[Any, Any, Any, Any], None]] = None, visitor_operand_after: Optional[Callable[[Any, Any, Any, Any], None]] = None, visitor_text: Optional[Callable[[Any, Any, Any, Any, Any], None]] = None, ) -> str: """ Extract text from an XObject. Args: xform: orientations: space_width: force default space width (if not extracted from font (default 200) visitor_operand_before: visitor_operand_after: visitor_text: Returns: The extracted text """ return self._extract_text( xform, self.pdf, orientations, space_width, None, visitor_operand_before, visitor_operand_after, visitor_text, ) def _get_fonts(self) -> tuple[set[str], set[str]]: """ Get the names of embedded fonts and unembedded fonts. Returns: A tuple (set of embedded fonts, set of unembedded fonts) """ obj = self.get_object() assert isinstance(obj, DictionaryObject) fonts: set[str] = set() embedded: set[str] = set() fonts, embedded = _get_fonts_walk(obj, fonts, embedded) unembedded = fonts - embedded return embedded, unembedded mediabox = _create_rectangle_accessor(PG.MEDIABOX, ()) """A :class:`RectangleObject`, expressed in default user space units, defining the boundaries of the physical medium on which the page is intended to be displayed or printed.""" cropbox = _create_rectangle_accessor("/CropBox", (PG.MEDIABOX,)) """ A :class:`RectangleObject`, expressed in default user space units, defining the visible region of default user space. When the page is displayed or printed, its contents are to be clipped (cropped) to this rectangle and then imposed on the output medium in some implementation-defined manner. Default value: same as :attr:`mediabox`. """ bleedbox = _create_rectangle_accessor("/BleedBox", ("/CropBox", PG.MEDIABOX)) """A :class:`RectangleObject`, expressed in default user space units, defining the region to which the contents of the page should be clipped when output in a production environment.""" trimbox = _create_rectangle_accessor("/TrimBox", ("/CropBox", PG.MEDIABOX)) """A :class:`RectangleObject`, expressed in default user space units, defining the intended dimensions of the finished page after trimming.""" artbox = _create_rectangle_accessor("/ArtBox", ("/CropBox", PG.MEDIABOX)) """A :class:`RectangleObject`, expressed in default user space units, defining the extent of the page's meaningful content as intended by the page's creator.""" @property def annotations(self) -> Optional[ArrayObject]: if "/Annots" not in self: return None return cast(ArrayObject, self["/Annots"]) @annotations.setter def annotations(self, value: Optional[ArrayObject]) -> None: """ Set the annotations array of the page. Typically you do not want to set this value, but append to it. If you append to it, remember to add the object first to the writer and only add the indirect object. """ if value is None: del self[NameObject("/Annots")] else: self[NameObject("/Annots")] = value class _VirtualList(Sequence[PageObject]): def __init__( self, length_function: Callable[[], int], get_function: Callable[[int], PageObject], ) -> None: self.length_function = length_function self.get_function = get_function self.current = -1 def __len__(self) -> int: return self.length_function() @overload def __getitem__(self, index: int) -> PageObject: ... @overload def __getitem__(self, index: slice) -> Sequence[PageObject]: ... def __getitem__( self, index: Union[int, slice] ) -> Union[PageObject, Sequence[PageObject]]: if isinstance(index, slice): indices = range(*index.indices(len(self))) cls = type(self) return cls(indices.__len__, lambda idx: self[indices[idx]]) if not isinstance(index, int): raise TypeError("Sequence indices must be integers") len_self = len(self) if index < 0: # support negative indexes index += len_self if not (0 <= index < len_self): raise IndexError("Sequence index out of range") return self.get_function(index) def __delitem__(self, index: Union[int, slice]) -> None: if isinstance(index, slice): r = list(range(*index.indices(len(self)))) # pages have to be deleted from last to first r.sort() r.reverse() for p in r: del self[p] # recursive call return if not isinstance(index, int): raise TypeError("Index must be integers") len_self = len(self) if index < 0: # support negative indexes index += len_self if not (0 <= index < len_self): raise IndexError("Index out of range") ind = self[index].indirect_reference assert ind is not None parent: Optional[PdfObject] = cast(DictionaryObject, ind.get_object()).get( "/Parent", None ) first = True while parent is not None: parent = cast(DictionaryObject, parent.get_object()) try: i = cast(ArrayObject, parent["/Kids"]).index(ind) del cast(ArrayObject, parent["/Kids"])[i] first = False try: assert ind is not None del ind.pdf.flattened_pages[index] # case of page in a Reader except Exception: # pragma: no cover pass if "/Count" in parent: parent[NameObject("/Count")] = NumberObject( cast(int, parent["/Count"]) - 1 ) if len(cast(ArrayObject, parent["/Kids"])) == 0: # No more objects in this part of this subtree ind = parent.indirect_reference parent = parent.get("/Parent", None) except ValueError: # from index if first: raise PdfReadError(f"Page not found in page tree: {ind}") break def __iter__(self) -> Iterator[PageObject]: for i in range(len(self)): yield self[i] def __str__(self) -> str: p = [f"PageObject({i})" for i in range(self.length_function())] return f"[{', '.join(p)}]" def _get_fonts_walk( obj: DictionaryObject, fnt: set[str], emb: set[str], ) -> tuple[set[str], set[str]]: """ Get the set of all fonts and all embedded fonts. Args: obj: Page resources dictionary fnt: font emb: embedded fonts Returns: A tuple (fnt, emb) If there is a key called 'BaseFont', that is a font that is used in the document. If there is a key called 'FontName' and another key in the same dictionary object that is called 'FontFilex' (where x is null, 2, or 3), then that fontname is embedded. We create and add to two sets, fnt = fonts used and emb = fonts embedded. """ fontkeys = ("/FontFile", "/FontFile2", "/FontFile3") def process_font(f: DictionaryObject) -> None: nonlocal fnt, emb f = cast(DictionaryObject, f.get_object()) # to be sure if "/BaseFont" in f: fnt.add(cast(str, f["/BaseFont"])) if ( ("/CharProcs" in f) or ( "/FontDescriptor" in f and any( x in cast(DictionaryObject, f["/FontDescriptor"]) for x in fontkeys ) ) or ( "/DescendantFonts" in f and "/FontDescriptor" in cast( DictionaryObject, cast(ArrayObject, f["/DescendantFonts"])[0].get_object(), ) and any( x in cast( DictionaryObject, cast( DictionaryObject, cast(ArrayObject, f["/DescendantFonts"])[0].get_object(), )["/FontDescriptor"], ) for x in fontkeys ) ) ): # the list comprehension ensures there is FontFile try: emb.add(cast(str, f["/BaseFont"])) except KeyError: emb.add("(" + cast(str, f["/Subtype"]) + ")") if "/DR" in obj and "/Font" in cast(DictionaryObject, obj["/DR"]): for f in cast(DictionaryObject, cast(DictionaryObject, obj["/DR"])["/Font"]): process_font(f) if "/Resources" in obj: if "/Font" in cast(DictionaryObject, obj["/Resources"]): for f in cast( DictionaryObject, cast(DictionaryObject, obj["/Resources"])["/Font"] ).values(): process_font(f) if "/XObject" in cast(DictionaryObject, obj["/Resources"]): for x in cast( DictionaryObject, cast(DictionaryObject, obj["/Resources"])["/XObject"] ).values(): _get_fonts_walk(cast(DictionaryObject, x.get_object()), fnt, emb) if "/Annots" in obj: for a in cast(ArrayObject, obj["/Annots"]): _get_fonts_walk(cast(DictionaryObject, a.get_object()), fnt, emb) if "/AP" in obj: if ( cast(DictionaryObject, cast(DictionaryObject, obj["/AP"])["/N"]).get( "/Type" ) == "/XObject" ): _get_fonts_walk( cast(DictionaryObject, cast(DictionaryObject, obj["/AP"])["/N"]), fnt, emb, ) else: for a in cast(DictionaryObject, cast(DictionaryObject, obj["/AP"])["/N"]): _get_fonts_walk(cast(DictionaryObject, a), fnt, emb) return fnt, emb # return the sets for each page pypdf-6.1.2/pypdf/_page_labels.py000066400000000000000000000205421507516550200167440ustar00rootroot00000000000000""" Page labels are shown by PDF viewers as "the page number". A page has a numeric index, starting at 0. Additionally, the page has a label. In the most simple case: label = index + 1 However, the title page and the table of contents might have Roman numerals as page labels. This makes things more complicated. Example 1 --------- >>> reader.root_object["/PageLabels"]["/Nums"] [0, IndirectObject(18, 0, 139929798197504), 8, IndirectObject(19, 0, 139929798197504)] >>> reader.get_object(reader.root_object["/PageLabels"]["/Nums"][1]) {'/S': '/r'} >>> reader.get_object(reader.root_object["/PageLabels"]["/Nums"][3]) {'/S': '/D'} Example 2 --------- The following is a document with pages labeled i, ii, iii, iv, 1, 2, 3, A-8, A-9, ... 1 0 obj << /Type /Catalog /PageLabels << /Nums [ 0 << /S /r >> 4 << /S /D >> 7 << /S /D /P ( A- ) /St 8 >> % A number tree containing % three page label dictionaries ] >> ... >> endobj §12.4.2 PDF Specification 1.7 and 2.0 ===================================== Entries in a page label dictionary ---------------------------------- The /S key: D Decimal Arabic numerals R Uppercase Roman numerals r Lowercase Roman numerals A Uppercase letters (A to Z for the first 26 pages, AA to ZZ for the next 26, and so on) a Lowercase letters (a to z for the first 26 pages, aa to zz for the next 26, and so on) """ from collections.abc import Iterator from typing import Optional, cast from ._protocols import PdfCommonDocProtocol from ._utils import logger_warning from .generic import ( ArrayObject, DictionaryObject, NullObject, NumberObject, is_null_or_none, ) def number2uppercase_roman_numeral(num: int) -> str: roman = [ (1000, "M"), (900, "CM"), (500, "D"), (400, "CD"), (100, "C"), (90, "XC"), (50, "L"), (40, "XL"), (10, "X"), (9, "IX"), (5, "V"), (4, "IV"), (1, "I"), ] def roman_num(num: int) -> Iterator[str]: for decimal, roman_repr in roman: x, _ = divmod(num, decimal) yield roman_repr * x num -= decimal * x if num <= 0: break return "".join(list(roman_num(num))) def number2lowercase_roman_numeral(number: int) -> str: return number2uppercase_roman_numeral(number).lower() def number2uppercase_letter(number: int) -> str: if number <= 0: raise ValueError("Expecting a positive number") alphabet = [chr(i) for i in range(ord("A"), ord("Z") + 1)] rep = "" while number > 0: remainder = number % 26 if remainder == 0: remainder = 26 rep = alphabet[remainder - 1] + rep # update number -= remainder number = number // 26 return rep def number2lowercase_letter(number: int) -> str: return number2uppercase_letter(number).lower() def get_label_from_nums(dictionary_object: DictionaryObject, index: int) -> str: # [Nums] shall be an array of the form # [ key_1 value_1 key_2 value_2 ... key_n value_n ] # where each key_i is an integer and the corresponding # value_i shall be the object associated with that key. # The keys shall be sorted in numerical order, # analogously to the arrangement of keys in a name tree # as described in 7.9.6, "Name Trees." nums = cast(ArrayObject, dictionary_object["/Nums"]) i = 0 value = None start_index = 0 while i < len(nums): start_index = nums[i] value = nums[i + 1].get_object() if i + 2 == len(nums): break if nums[i + 2] > index: break i += 2 m = { None: lambda _: "", "/D": lambda n: str(n), "/R": number2uppercase_roman_numeral, "/r": number2lowercase_roman_numeral, "/A": number2uppercase_letter, "/a": number2lowercase_letter, } # if /Nums array is not following the specification or if /Nums is empty if not isinstance(value, dict): return str(index + 1) # Fallback start = value.get("/St", 1) prefix = value.get("/P", "") return prefix + m[value.get("/S")](index - start_index + start) def index2label(reader: PdfCommonDocProtocol, index: int) -> str: """ See 7.9.7 "Number Trees". Args: reader: The PdfReader index: The index of the page Returns: The label of the page, e.g. "iv" or "4". """ root = cast(DictionaryObject, reader.root_object) if "/PageLabels" not in root: return str(index + 1) # Fallback number_tree = cast(DictionaryObject, root["/PageLabels"].get_object()) if "/Nums" in number_tree: return get_label_from_nums(number_tree, index) if "/Kids" in number_tree and not isinstance(number_tree["/Kids"], NullObject): # number_tree = {'/Kids': [IndirectObject(7333, 0, 140132998195856), ...]} # Limit maximum depth. level = 0 while level < 100: kids = cast(list[DictionaryObject], number_tree["/Kids"]) for kid in kids: # kid = {'/Limits': [0, 63], '/Nums': [0, {'/P': 'C1'}, ...]} limits = cast(list[int], kid["/Limits"]) if limits[0] <= index <= limits[1]: if not is_null_or_none(kid.get("/Kids", None)): # Recursive definition. level += 1 if level == 100: # pragma: no cover raise NotImplementedError( "Too deep nesting is not supported." ) number_tree = kid # Exit the inner `for` loop and continue at the next level with the # next iteration of the `while` loop. break return get_label_from_nums(kid, index) else: # When there are no kids, make sure to exit the `while` loop directly # and continue with the fallback. break logger_warning(f"Could not reliably determine page label for {index}.", __name__) return str(index + 1) # Fallback if neither /Nums nor /Kids is in the number_tree def nums_insert( key: NumberObject, value: DictionaryObject, nums: ArrayObject, ) -> None: """ Insert a key, value pair in a Nums array. See 7.9.7 "Number Trees". Args: key: number key of the entry value: value of the entry nums: Nums array to modify """ if len(nums) % 2 != 0: raise ValueError("A nums like array must have an even number of elements") i = len(nums) while i != 0 and key <= nums[i - 2]: i = i - 2 if i < len(nums) and key == nums[i]: nums[i + 1] = value else: nums.insert(i, key) nums.insert(i + 1, value) def nums_clear_range( key: NumberObject, page_index_to: int, nums: ArrayObject, ) -> None: """ Remove all entries in a number tree in a range after an entry. See 7.9.7 "Number Trees". Args: key: number key of the entry before the range page_index_to: The page index of the upper limit of the range nums: Nums array to modify """ if len(nums) % 2 != 0: raise ValueError("A nums like array must have an even number of elements") if page_index_to < key: raise ValueError("page_index_to must be greater or equal than key") i = nums.index(key) + 2 while i < len(nums) and nums[i] <= page_index_to: nums.pop(i) nums.pop(i) def nums_next( key: NumberObject, nums: ArrayObject, ) -> tuple[Optional[NumberObject], Optional[DictionaryObject]]: """ Return the (key, value) pair of the entry after the given one. See 7.9.7 "Number Trees". Args: key: number key of the entry nums: Nums array """ if len(nums) % 2 != 0: raise ValueError("A nums like array must have an even number of elements") i = nums.index(key) + 2 if i < len(nums): return (nums[i], nums[i + 1]) return (None, None) pypdf-6.1.2/pypdf/_protocols.py000066400000000000000000000041131507516550200165260ustar00rootroot00000000000000"""Helpers for working with PDF types.""" from abc import abstractmethod from pathlib import Path from typing import IO, Any, Optional, Protocol, Union from ._utils import StrByteType, StreamType class PdfObjectProtocol(Protocol): indirect_reference: Any def clone( self, pdf_dest: Any, force_duplicate: bool = False, ignore_fields: Union[tuple[str, ...], list[str], None] = (), ) -> Any: ... # pragma: no cover def _reference_clone(self, clone: Any, pdf_dest: Any) -> Any: ... # pragma: no cover def get_object(self) -> Optional["PdfObjectProtocol"]: ... # pragma: no cover def hash_value(self) -> bytes: ... # pragma: no cover def write_to_stream( self, stream: StreamType, encryption_key: Union[None, str, bytes] = None ) -> None: ... # pragma: no cover class XmpInformationProtocol(PdfObjectProtocol): pass class PdfCommonDocProtocol(Protocol): @property def pdf_header(self) -> str: ... # pragma: no cover @property def pages(self) -> list[Any]: ... # pragma: no cover @property def root_object(self) -> PdfObjectProtocol: ... # pragma: no cover def get_object(self, indirect_reference: Any) -> Optional[PdfObjectProtocol]: ... # pragma: no cover @property def strict(self) -> bool: ... # pragma: no cover class PdfReaderProtocol(PdfCommonDocProtocol, Protocol): @property @abstractmethod def xref(self) -> dict[int, dict[int, Any]]: ... # pragma: no cover @property @abstractmethod def trailer(self) -> dict[str, Any]: ... # pragma: no cover class PdfWriterProtocol(PdfCommonDocProtocol, Protocol): _objects: list[Any] _id_translated: dict[int, dict[int, int]] incremental: bool _reader: Any # PdfReader @abstractmethod def write(self, stream: Union[Path, StrByteType]) -> tuple[bool, IO[Any]]: ... # pragma: no cover @abstractmethod def _add_object(self, obj: Any) -> Any: ... # pragma: no cover pypdf-6.1.2/pypdf/_reader.py000066400000000000000000001450771507516550200157630ustar00rootroot00000000000000# Copyright (c) 2006, Mathieu Fenniak # Copyright (c) 2007, Ashish Kulkarni # # All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. import os import re from collections.abc import Iterable from io import BytesIO, UnsupportedOperation from pathlib import Path from types import TracebackType from typing import ( TYPE_CHECKING, Any, Callable, Optional, Union, cast, ) from ._doc_common import PdfDocCommon, convert_to_int from ._encryption import Encryption, PasswordType from ._utils import ( StrByteType, StreamType, logger_warning, read_non_whitespace, read_previous_line, read_until_whitespace, skip_over_comment, skip_over_whitespace, ) from .constants import TrailerKeys as TK from .errors import ( EmptyFileError, FileNotDecryptedError, PdfReadError, PdfStreamError, WrongPasswordError, ) from .generic import ( ArrayObject, ContentStream, DecodedStreamObject, DictionaryObject, EncodedStreamObject, IndirectObject, NameObject, NullObject, NumberObject, PdfObject, StreamObject, TextStringObject, is_null_or_none, read_object, ) from .xmp import XmpInformation if TYPE_CHECKING: from ._page import PageObject class PdfReader(PdfDocCommon): """ Initialize a PdfReader object. This operation can take some time, as the PDF stream's cross-reference tables are read into memory. Args: stream: A File object or an object that supports the standard read and seek methods similar to a File object. Could also be a string representing a path to a PDF file. strict: Determines whether user should be warned of all problems and also causes some correctable problems to be fatal. Defaults to ``False``. password: Decrypt PDF file at initialization. If the password is None, the file will not be decrypted. Defaults to ``None``. """ def __init__( self, stream: Union[StrByteType, Path], strict: bool = False, password: Union[None, str, bytes] = None, ) -> None: self.strict = strict self.flattened_pages: Optional[list[PageObject]] = None #: Storage of parsed PDF objects. self.resolved_objects: dict[tuple[Any, Any], Optional[PdfObject]] = {} self._startxref: int = 0 self.xref_index = 0 self.xref: dict[int, dict[Any, Any]] = {} self.xref_free_entry: dict[int, dict[Any, Any]] = {} self.xref_objStm: dict[int, tuple[Any, Any]] = {} self.trailer = DictionaryObject() # Map page indirect_reference number to page number self._page_id2num: Optional[dict[Any, Any]] = None self._validated_root: Optional[DictionaryObject] = None self._initialize_stream(stream) self._known_objects: set[tuple[int, int]] = set() self._override_encryption = False self._encryption: Optional[Encryption] = None if self.is_encrypted: self._handle_encryption(password) elif password is not None: raise PdfReadError("Not an encrypted file") def _initialize_stream(self, stream: Union[StrByteType, Path]) -> None: if hasattr(stream, "mode") and "b" not in stream.mode: logger_warning( "PdfReader stream/file object is not in binary mode. " "It may not be read correctly.", __name__, ) self._stream_opened = False if isinstance(stream, (str, Path)): with open(stream, "rb") as fh: stream = BytesIO(fh.read()) self._stream_opened = True self.read(stream) self.stream = stream def _handle_encryption(self, password: Optional[Union[str, bytes]]) -> None: self._override_encryption = True # Some documents may not have a /ID, use two empty # byte strings instead. Solves # https://github.com/py-pdf/pypdf/issues/608 id_entry = self.trailer.get(TK.ID) id1_entry = id_entry[0].get_object().original_bytes if id_entry else b"" encrypt_entry = cast(DictionaryObject, self.trailer[TK.ENCRYPT].get_object()) self._encryption = Encryption.read(encrypt_entry, id1_entry) # try empty password if no password provided pwd = password if password is not None else b"" if ( self._encryption.verify(pwd) == PasswordType.NOT_DECRYPTED and password is not None ): # raise if password provided raise WrongPasswordError("Wrong password") self._override_encryption = False def __enter__(self) -> "PdfReader": return self def __exit__( self, exc_type: Optional[type[BaseException]], exc_val: Optional[BaseException], exc_tb: Optional[TracebackType], ) -> None: self.close() def close(self) -> None: """Close the stream if opened in __init__ and clear memory.""" if self._stream_opened: self.stream.close() self.flattened_pages = [] self.resolved_objects = {} self.trailer = DictionaryObject() self.xref = {} self.xref_free_entry = {} self.xref_objStm = {} @property def root_object(self) -> DictionaryObject: """Provide access to "/Root". Standardized with PdfWriter.""" if self._validated_root: return self._validated_root root = self.trailer.get(TK.ROOT) if is_null_or_none(root): logger_warning('Cannot find "/Root" key in trailer', __name__) elif ( cast(DictionaryObject, cast(PdfObject, root).get_object()).get("/Type") == "/Catalog" ): self._validated_root = cast( DictionaryObject, cast(PdfObject, root).get_object() ) else: logger_warning("Invalid Root object in trailer", __name__) if self._validated_root is None: logger_warning('Searching object with "/Catalog" key', __name__) nb = cast(int, self.trailer.get("/Size", 0)) for i in range(nb): try: o = self.get_object(i + 1) except Exception: # to be sure to capture all errors o = None if isinstance(o, DictionaryObject) and o.get("/Type") == "/Catalog": self._validated_root = o logger_warning(f"Root found at {o.indirect_reference!r}", __name__) break if self._validated_root is None: if not is_null_or_none(root) and "/Pages" in cast(DictionaryObject, cast(PdfObject, root).get_object()): logger_warning( f"Possible root found at {cast(PdfObject, root).indirect_reference!r}, but missing /Catalog key", __name__ ) self._validated_root = cast( DictionaryObject, cast(PdfObject, root).get_object() ) else: raise PdfReadError("Cannot find Root object in pdf") return self._validated_root @property def _info(self) -> Optional[DictionaryObject]: """ Provide access to "/Info". Standardized with PdfWriter. Returns: /Info Dictionary; None if the entry does not exist """ info = self.trailer.get(TK.INFO, None) if is_null_or_none(info): return None assert info is not None, "mypy" info = info.get_object() if not isinstance(info, DictionaryObject): raise PdfReadError( "Trailer not found or does not point to a document information dictionary" ) return info @property def _ID(self) -> Optional[ArrayObject]: """ Provide access to "/ID". Standardized with PdfWriter. Returns: /ID array; None if the entry does not exist """ id = self.trailer.get(TK.ID, None) if is_null_or_none(id): return None assert id is not None, "mypy" return cast(ArrayObject, id.get_object()) @property def pdf_header(self) -> str: """ The first 8 bytes of the file. This is typically something like ``'%PDF-1.6'`` and can be used to detect if the file is actually a PDF file and which version it is. """ # TODO: Make this return a bytes object for consistency # but that needs a deprecation loc = self.stream.tell() self.stream.seek(0, 0) pdf_file_version = self.stream.read(8).decode("utf-8", "backslashreplace") self.stream.seek(loc, 0) # return to where it was return pdf_file_version @property def xmp_metadata(self) -> Optional[XmpInformation]: """XMP (Extensible Metadata Platform) data.""" try: self._override_encryption = True return cast(XmpInformation, self.root_object.xmp_metadata) finally: self._override_encryption = False def _get_page_number_by_indirect( self, indirect_reference: Union[None, int, NullObject, IndirectObject] ) -> Optional[int]: """ Retrieve the page number from an indirect reference. Args: indirect_reference: The indirect reference to locate. Returns: Page number or None. """ if self._page_id2num is None: self._page_id2num = { x.indirect_reference.idnum: i for i, x in enumerate(self.pages) # type: ignore } if is_null_or_none(indirect_reference): return None assert isinstance(indirect_reference, (int, IndirectObject)), "mypy" if isinstance(indirect_reference, int): idnum = indirect_reference else: idnum = indirect_reference.idnum assert self._page_id2num is not None, "hint for mypy" return self._page_id2num.get(idnum, None) def _get_object_from_stream( self, indirect_reference: IndirectObject ) -> Union[int, PdfObject, str]: # indirect reference to object in object stream # read the entire object stream into memory stmnum, idx = self.xref_objStm[indirect_reference.idnum] obj_stm: EncodedStreamObject = IndirectObject(stmnum, 0, self).get_object() # type: ignore # This is an xref to a stream, so its type better be a stream assert cast(str, obj_stm["/Type"]) == "/ObjStm" stream_data = BytesIO(obj_stm.get_data()) for i in range(obj_stm["/N"]): # type: ignore read_non_whitespace(stream_data) stream_data.seek(-1, 1) objnum = NumberObject.read_from_stream(stream_data) read_non_whitespace(stream_data) stream_data.seek(-1, 1) offset = NumberObject.read_from_stream(stream_data) read_non_whitespace(stream_data) stream_data.seek(-1, 1) if objnum != indirect_reference.idnum: # We're only interested in one object continue if self.strict and idx != i: raise PdfReadError("Object is in wrong index.") stream_data.seek(int(obj_stm["/First"] + offset), 0) # type: ignore # To cope with case where the 'pointer' is on a white space read_non_whitespace(stream_data) stream_data.seek(-1, 1) try: obj = read_object(stream_data, self) except PdfStreamError as exc: # Stream object cannot be read. Normally, a critical error, but # Adobe Reader doesn't complain, so continue (in strict mode?) logger_warning( f"Invalid stream (index {i}) within object " f"{indirect_reference.idnum} {indirect_reference.generation}: " f"{exc}", __name__, ) if self.strict: # pragma: no cover raise PdfReadError( f"Cannot read object stream: {exc}" ) # pragma: no cover # Replace with null. Hopefully it's nothing important. obj = NullObject() # pragma: no cover return obj if self.strict: # pragma: no cover raise PdfReadError( "This is a fatal error in strict mode." ) # pragma: no cover return NullObject() # pragma: no cover def get_object( self, indirect_reference: Union[int, IndirectObject] ) -> Optional[PdfObject]: if isinstance(indirect_reference, int): indirect_reference = IndirectObject(indirect_reference, 0, self) retval = self.cache_get_indirect_object( indirect_reference.generation, indirect_reference.idnum ) if retval is not None: return retval if ( indirect_reference.generation == 0 and indirect_reference.idnum in self.xref_objStm ): retval = self._get_object_from_stream(indirect_reference) # type: ignore elif ( indirect_reference.generation in self.xref and indirect_reference.idnum in self.xref[indirect_reference.generation] ): if self.xref_free_entry.get(indirect_reference.generation, {}).get( indirect_reference.idnum, False ): return NullObject() start = self.xref[indirect_reference.generation][indirect_reference.idnum] self.stream.seek(start, 0) try: idnum, generation = self.read_object_header(self.stream) if ( idnum != indirect_reference.idnum or generation != indirect_reference.generation ): raise PdfReadError("Not matching, we parse the file for it") except Exception: if hasattr(self.stream, "getbuffer"): buf = bytes(self.stream.getbuffer()) else: p = self.stream.tell() self.stream.seek(0, 0) buf = self.stream.read(-1) self.stream.seek(p, 0) m = re.search( rf"\s{indirect_reference.idnum}\s+{indirect_reference.generation}\s+obj".encode(), buf, ) if m is not None: logger_warning( f"Object ID {indirect_reference.idnum},{indirect_reference.generation} ref repaired", __name__, ) self.xref[indirect_reference.generation][ indirect_reference.idnum ] = (m.start(0) + 1) self.stream.seek(m.start(0) + 1) idnum, generation = self.read_object_header(self.stream) else: idnum = -1 generation = -1 # exception will be raised below if idnum != indirect_reference.idnum and self.xref_index: # xref table probably had bad indexes due to not being zero-indexed if self.strict: raise PdfReadError( f"Expected object ID ({indirect_reference.idnum} {indirect_reference.generation}) " f"does not match actual ({idnum} {generation}); " "xref table not zero-indexed." ) # xref table is corrected in non-strict mode elif idnum != indirect_reference.idnum and self.strict: # some other problem raise PdfReadError( f"Expected object ID ({indirect_reference.idnum} {indirect_reference.generation}) " f"does not match actual ({idnum} {generation})." ) if self.strict: assert generation == indirect_reference.generation current_object = (indirect_reference.idnum, indirect_reference.generation) if current_object in self._known_objects: raise PdfReadError(f"Detected loop with self reference for {indirect_reference!r}.") self._known_objects.add(current_object) retval = read_object(self.stream, self) # type: ignore self._known_objects.remove(current_object) # override encryption is used for the /Encrypt dictionary if not self._override_encryption and self._encryption is not None: # if we don't have the encryption key: if not self._encryption.is_decrypted(): raise FileNotDecryptedError("File has not been decrypted") # otherwise, decrypt here... retval = cast(PdfObject, retval) retval = self._encryption.decrypt_object( retval, indirect_reference.idnum, indirect_reference.generation ) else: if hasattr(self.stream, "getbuffer"): buf = bytes(self.stream.getbuffer()) else: p = self.stream.tell() self.stream.seek(0, 0) buf = self.stream.read(-1) self.stream.seek(p, 0) m = re.search( rf"\s{indirect_reference.idnum}\s+{indirect_reference.generation}\s+obj".encode(), buf, ) if m is not None: logger_warning( f"Object {indirect_reference.idnum} {indirect_reference.generation} found", __name__, ) if indirect_reference.generation not in self.xref: self.xref[indirect_reference.generation] = {} self.xref[indirect_reference.generation][indirect_reference.idnum] = ( m.start(0) + 1 ) self.stream.seek(m.end(0) + 1) skip_over_whitespace(self.stream) self.stream.seek(-1, 1) retval = read_object(self.stream, self) # type: ignore # override encryption is used for the /Encrypt dictionary if not self._override_encryption and self._encryption is not None: # if we don't have the encryption key: if not self._encryption.is_decrypted(): raise FileNotDecryptedError("File has not been decrypted") # otherwise, decrypt here... retval = cast(PdfObject, retval) retval = self._encryption.decrypt_object( retval, indirect_reference.idnum, indirect_reference.generation ) else: logger_warning( f"Object {indirect_reference.idnum} {indirect_reference.generation} not defined.", __name__, ) if self.strict: raise PdfReadError("Could not find object.") self.cache_indirect_object( indirect_reference.generation, indirect_reference.idnum, retval ) return retval def read_object_header(self, stream: StreamType) -> tuple[int, int]: # Should never be necessary to read out whitespace, since the # cross-reference table should put us in the right spot to read the # object header. In reality some files have stupid cross-reference # tables that are off by whitespace bytes. skip_over_comment(stream) extra = skip_over_whitespace(stream) stream.seek(-1, 1) idnum = read_until_whitespace(stream) extra |= skip_over_whitespace(stream) stream.seek(-1, 1) generation = read_until_whitespace(stream) extra |= skip_over_whitespace(stream) stream.seek(-1, 1) # although it's not used, it might still be necessary to read _obj = stream.read(3) read_non_whitespace(stream) stream.seek(-1, 1) if extra and self.strict: logger_warning( f"Superfluous whitespace found in object header {idnum} {generation}", # type: ignore __name__, ) return int(idnum), int(generation) def cache_get_indirect_object( self, generation: int, idnum: int ) -> Optional[PdfObject]: try: return self.resolved_objects.get((generation, idnum)) except RecursionError: raise PdfReadError("Maximum recursion depth reached.") def cache_indirect_object( self, generation: int, idnum: int, obj: Optional[PdfObject] ) -> Optional[PdfObject]: if (generation, idnum) in self.resolved_objects: msg = f"Overwriting cache for {generation} {idnum}" if self.strict: raise PdfReadError(msg) logger_warning(msg, __name__) self.resolved_objects[(generation, idnum)] = obj if obj is not None: obj.indirect_reference = IndirectObject(idnum, generation, self) return obj def _replace_object(self, indirect: IndirectObject, obj: PdfObject) -> PdfObject: # function reserved for future development if indirect.pdf != self: raise ValueError("Cannot update PdfReader with external object") if (indirect.generation, indirect.idnum) not in self.resolved_objects: raise ValueError("Cannot find referenced object") self.resolved_objects[(indirect.generation, indirect.idnum)] = obj obj.indirect_reference = indirect return obj def read(self, stream: StreamType) -> None: """ Read and process the PDF stream, extracting necessary data. Args: stream: The PDF file stream. """ self._basic_validation(stream) self._find_eof_marker(stream) startxref = self._find_startxref_pos(stream) self._startxref = startxref # check and eventually correct the startxref only if not strict xref_issue_nr = self._get_xref_issues(stream, startxref) if xref_issue_nr != 0: if self.strict and xref_issue_nr: raise PdfReadError("Broken xref table") logger_warning(f"incorrect startxref pointer({xref_issue_nr})", __name__) # read all cross-reference tables and their trailers self._read_xref_tables_and_trailers(stream, startxref, xref_issue_nr) # if not zero-indexed, verify that the table is correct; change it if necessary if self.xref_index and not self.strict: loc = stream.tell() for gen, xref_entry in self.xref.items(): if gen == 65535: continue xref_k = sorted( xref_entry.keys() ) # ensure ascending to prevent damage for id in xref_k: stream.seek(xref_entry[id], 0) try: pid, _pgen = self.read_object_header(stream) except ValueError: self._rebuild_xref_table(stream) break if pid == id - self.xref_index: # fixing index item per item is required for revised PDF. self.xref[gen][pid] = self.xref[gen][id] del self.xref[gen][id] # if not, then either it's just plain wrong, or the # non-zero-index is actually correct stream.seek(loc, 0) # return to where it was # remove wrong objects (not pointing to correct structures) - cf #2326 if not self.strict: loc = stream.tell() for gen, xref_entry in self.xref.items(): if gen == 65535: continue ids = list(xref_entry.keys()) for id in ids: stream.seek(xref_entry[id], 0) try: self.read_object_header(stream) except ValueError: logger_warning( f"Ignoring wrong pointing object {id} {gen} (offset {xref_entry[id]})", __name__, ) del xref_entry[id] # we can delete the id, we are parsing ids stream.seek(loc, 0) # return to where it was def _basic_validation(self, stream: StreamType) -> None: """Ensure the stream is valid and not empty.""" stream.seek(0, os.SEEK_SET) try: header_byte = stream.read(5) except UnicodeDecodeError: raise UnsupportedOperation("cannot read header") if header_byte == b"": raise EmptyFileError("Cannot read an empty file") if header_byte != b"%PDF-": if self.strict: raise PdfReadError( f"PDF starts with '{header_byte.decode('utf8')}', " "but '%PDF-' expected" ) logger_warning(f"invalid pdf header: {header_byte}", __name__) stream.seek(0, os.SEEK_END) def _find_eof_marker(self, stream: StreamType) -> None: """ Jump to the %%EOF marker. According to the specs, the %%EOF marker should be at the very end of the file. Hence for standard-compliant PDF documents this function will read only the last part (DEFAULT_BUFFER_SIZE). """ HEADER_SIZE = 8 # to parse whole file, Header is e.g. '%PDF-1.6' line = b"" first = True while not line.startswith(b"%%EOF"): if line != b"" and first: if any( line.strip().endswith(tr) for tr in (b"%%EO", b"%%E", b"%%", b"%") ): # Consider the file as truncated while # having enough confidence to carry on. logger_warning("EOF marker seems truncated", __name__) break first = False if b"startxref" in line: logger_warning( "CAUTION: startxref found while searching for %%EOF. " "The file might be truncated and some data might not be read.", __name__, ) if stream.tell() < HEADER_SIZE: if self.strict: raise PdfReadError("EOF marker not found") logger_warning("EOF marker not found", __name__) line = read_previous_line(stream) def _find_startxref_pos(self, stream: StreamType) -> int: """ Find startxref entry - the location of the xref table. Args: stream: Returns: The bytes offset """ line = read_previous_line(stream) try: startxref = int(line) except ValueError: # 'startxref' may be on the same line as the location if not line.startswith(b"startxref"): raise PdfReadError("startxref not found") startxref = int(line[9:].strip()) logger_warning("startxref on same line as offset", __name__) else: line = read_previous_line(stream) if not line.startswith(b"startxref"): raise PdfReadError("startxref not found") return startxref def _read_standard_xref_table(self, stream: StreamType) -> None: # standard cross-reference table ref = stream.read(3) if ref != b"ref": raise PdfReadError("xref table read error") read_non_whitespace(stream) stream.seek(-1, 1) first_time = True # check if the first time looking at the xref table while True: num = cast(int, read_object(stream, self)) if first_time and num != 0: self.xref_index = num if self.strict: logger_warning( "Xref table not zero-indexed. ID numbers for objects will be corrected.", __name__, ) # if table not zero indexed, could be due to error from when PDF was created # which will lead to mismatched indices later on, only warned and corrected if self.strict==True first_time = False read_non_whitespace(stream) stream.seek(-1, 1) size = cast(int, read_object(stream, self)) if not isinstance(size, int): logger_warning( "Invalid/Truncated xref table. Rebuilding it.", __name__, ) self._rebuild_xref_table(stream) stream.read() return read_non_whitespace(stream) stream.seek(-1, 1) cnt = 0 while cnt < size: line = stream.read(20) if not line: raise PdfReadError("Unexpected empty line in Xref table.") # It's very clear in section 3.4.3 of the PDF spec # that all cross-reference table lines are a fixed # 20 bytes (as of PDF 1.7). However, some files have # 21-byte entries (or more) due to the use of \r\n # (CRLF) EOL's. Detect that case, and adjust the line # until it does not begin with a \r (CR) or \n (LF). while line[0] in b"\x0D\x0A": stream.seek(-20 + 1, 1) line = stream.read(20) # On the other hand, some malformed PDF files # use a single character EOL without a preceding # space. Detect that case, and seek the stream # back one character (0-9 means we've bled into # the next xref entry, t means we've bled into the # text "trailer"): if line[-1] in b"0123456789t": stream.seek(-1, 1) try: offset_b, generation_b = line[:16].split(b" ") entry_type_b = line[17:18] offset, generation = int(offset_b), int(generation_b) except Exception: if hasattr(stream, "getbuffer"): buf = bytes(stream.getbuffer()) else: p = stream.tell() stream.seek(0, 0) buf = stream.read(-1) stream.seek(p) f = re.search(rf"{num}\s+(\d+)\s+obj".encode(), buf) if f is None: logger_warning( f"entry {num} in Xref table invalid; object not found", __name__, ) generation = 65535 offset = -1 entry_type_b = b"f" else: logger_warning( f"entry {num} in Xref table invalid but object found", __name__, ) generation = int(f.group(1)) offset = f.start() if generation not in self.xref: self.xref[generation] = {} self.xref_free_entry[generation] = {} if num in self.xref[generation]: # It really seems like we should allow the last # xref table in the file to override previous # ones. Since we read the file backwards, assume # any existing key is already set correctly. pass else: if entry_type_b == b"n": self.xref[generation][num] = offset try: self.xref_free_entry[generation][num] = entry_type_b == b"f" except Exception: pass try: self.xref_free_entry[65535][num] = entry_type_b == b"f" except Exception: pass cnt += 1 num += 1 read_non_whitespace(stream) stream.seek(-1, 1) trailer_tag = stream.read(7) if trailer_tag != b"trailer": # more xrefs! stream.seek(-7, 1) else: break def _read_xref_tables_and_trailers( self, stream: StreamType, startxref: Optional[int], xref_issue_nr: int ) -> None: """Read the cross-reference tables and trailers in the PDF stream.""" self.xref = {} self.xref_free_entry = {} self.xref_objStm = {} self.trailer = DictionaryObject() while startxref is not None: # load the xref table stream.seek(startxref, 0) x = stream.read(1) if x in b"\r\n": x = stream.read(1) if x == b"x": startxref = self._read_xref(stream) elif xref_issue_nr: try: self._rebuild_xref_table(stream) break except Exception: xref_issue_nr = 0 elif x.isdigit(): try: xrefstream = self._read_pdf15_xref_stream(stream) except Exception as e: if TK.ROOT in self.trailer: logger_warning( f"Previous trailer cannot be read: {e.args}", __name__ ) break raise PdfReadError(f"Trailer cannot be read: {e!s}") self._process_xref_stream(xrefstream) if "/Prev" in xrefstream: startxref = cast(int, xrefstream["/Prev"]) else: break else: startxref = self._read_xref_other_error(stream, startxref) def _process_xref_stream(self, xrefstream: DictionaryObject) -> None: """Process and handle the xref stream.""" trailer_keys = TK.ROOT, TK.ENCRYPT, TK.INFO, TK.ID, TK.SIZE for key in trailer_keys: if key in xrefstream and key not in self.trailer: self.trailer[NameObject(key)] = xrefstream.raw_get(key) if "/XRefStm" in xrefstream: p = self.stream.tell() self.stream.seek(cast(int, xrefstream["/XRefStm"]) + 1, 0) self._read_pdf15_xref_stream(self.stream) self.stream.seek(p, 0) def _read_xref(self, stream: StreamType) -> Optional[int]: self._read_standard_xref_table(stream) if stream.read(1) == b"": return None stream.seek(-1, 1) read_non_whitespace(stream) stream.seek(-1, 1) new_trailer = cast(dict[str, Any], read_object(stream, self)) for key, value in new_trailer.items(): if key not in self.trailer: self.trailer[key] = value if "/XRefStm" in new_trailer: p = stream.tell() stream.seek(cast(int, new_trailer["/XRefStm"]) + 1, 0) try: self._read_pdf15_xref_stream(stream) except Exception: logger_warning( f"XRef object at {new_trailer['/XRefStm']} can not be read, some object may be missing", __name__, ) stream.seek(p, 0) if "/Prev" in new_trailer: return new_trailer["/Prev"] return None def _read_xref_other_error( self, stream: StreamType, startxref: int ) -> Optional[int]: # some PDFs have /Prev=0 in the trailer, instead of no /Prev if startxref == 0: if self.strict: raise PdfReadError( "/Prev=0 in the trailer (try opening with strict=False)" ) logger_warning( "/Prev=0 in the trailer - assuming there is no previous xref table", __name__, ) return None # bad xref character at startxref. Let's see if we can find # the xref table nearby, as we've observed this error with an # off-by-one before. stream.seek(-11, 1) tmp = stream.read(20) xref_loc = tmp.find(b"xref") if xref_loc != -1: startxref -= 10 - xref_loc return startxref # No explicit xref table, try finding a cross-reference stream. stream.seek(startxref, 0) for look in range(25): # value extended to cope with more linearized files if stream.read(1).isdigit(): # This is not a standard PDF, consider adding a warning startxref += look return startxref # no xref table found at specified location if "/Root" in self.trailer and not self.strict: # if Root has been already found, just raise warning logger_warning("Invalid parent xref., rebuild xref", __name__) try: self._rebuild_xref_table(stream) return None except Exception: raise PdfReadError("Cannot rebuild xref") raise PdfReadError("Could not find xref table at specified location") def _read_pdf15_xref_stream( self, stream: StreamType ) -> Union[ContentStream, EncodedStreamObject, DecodedStreamObject]: """Read the cross-reference stream for PDF 1.5+.""" stream.seek(-1, 1) idnum, generation = self.read_object_header(stream) xrefstream = cast(ContentStream, read_object(stream, self)) if cast(str, xrefstream["/Type"]) != "/XRef": raise PdfReadError(f"Unexpected type {xrefstream['/Type']!r}") self.cache_indirect_object(generation, idnum, xrefstream) # Index pairs specify the subsections in the dictionary. # If none, create one subsection that spans everything. if "/Size" not in xrefstream: # According to table 17 of the PDF 2.0 specification, this key is required. raise PdfReadError(f"Size missing from XRef stream {xrefstream!r}!") idx_pairs = xrefstream.get("/Index", [0, xrefstream["/Size"]]) entry_sizes = cast(dict[Any, Any], xrefstream.get("/W")) assert len(entry_sizes) >= 3 if self.strict and len(entry_sizes) > 3: raise PdfReadError(f"Too many entry sizes: {entry_sizes}") stream_data = BytesIO(xrefstream.get_data()) def get_entry(i: int) -> Union[int, tuple[int, ...]]: # Reads the correct number of bytes for each entry. See the # discussion of the W parameter in PDF spec table 17. if entry_sizes[i] > 0: d = stream_data.read(entry_sizes[i]) return convert_to_int(d, entry_sizes[i]) # PDF Spec Table 17: A value of zero for an element in the # W array indicates...the default value shall be used if i == 0: return 1 # First value defaults to 1 return 0 def used_before(num: int, generation: Union[int, tuple[int, ...]]) -> bool: # We move backwards through the xrefs, don't replace any. return num in self.xref.get(generation, []) or num in self.xref_objStm # type: ignore # Iterate through each subsection self._read_xref_subsections(idx_pairs, get_entry, used_before) return xrefstream @staticmethod def _get_xref_issues(stream: StreamType, startxref: int) -> int: """ Return an int which indicates an issue. 0 means there is no issue. Args: stream: startxref: Returns: 0 means no issue, other values represent specific issues. """ if startxref == 0: return 4 stream.seek(startxref - 1, 0) # -1 to check character before line = stream.read(1) if line == b"j": line = stream.read(1) if line not in b"\r\n \t": return 1 line = stream.read(4) if line != b"xref": # not a xref so check if it is an XREF object line = b"" while line in b"0123456789 \t": line = stream.read(1) if line == b"": return 2 line += stream.read(2) # 1 char already read, +2 to check "obj" if line.lower() != b"obj": return 3 return 0 def _rebuild_xref_table(self, stream: StreamType) -> None: self.xref = {} stream.seek(0, 0) f_ = stream.read(-1) for m in re.finditer(rb"[\r\n \t][ \t]*(\d+)[ \t]+(\d+)[ \t]+obj", f_): idnum = int(m.group(1)) generation = int(m.group(2)) if generation not in self.xref: self.xref[generation] = {} self.xref[generation][idnum] = m.start(1) logger_warning("parsing for Object Streams", __name__) for g in self.xref: for i in self.xref[g]: # get_object in manual stream.seek(self.xref[g][i], 0) try: _ = self.read_object_header(stream) o = cast(StreamObject, read_object(stream, self)) if o.get("/Type", "") != "/ObjStm": continue strm = BytesIO(o.get_data()) cpt = 0 while True: s = read_until_whitespace(strm) if not s.isdigit(): break _i = int(s) skip_over_whitespace(strm) strm.seek(-1, 1) s = read_until_whitespace(strm) if not s.isdigit(): # pragma: no cover break # pragma: no cover _o = int(s) self.xref_objStm[_i] = (i, _o) cpt += 1 if cpt != o.get("/N"): # pragma: no cover logger_warning( # pragma: no cover f"found {cpt} objects within Object({i},{g})" f" whereas {o.get('/N')} expected", __name__, ) except Exception: # could be multiple causes pass stream.seek(0, 0) for m in re.finditer(rb"[\r\n \t][ \t]*trailer[\r\n \t]*(<<)", f_): stream.seek(m.start(1), 0) new_trailer = cast(dict[Any, Any], read_object(stream, self)) # Here, we are parsing the file from start to end, the new data have to erase the existing. for key, value in list(new_trailer.items()): self.trailer[key] = value def _read_xref_subsections( self, idx_pairs: list[int], get_entry: Callable[[int], Union[int, tuple[int, ...]]], used_before: Callable[[int, Union[int, tuple[int, ...]]], bool], ) -> None: """Read and process the subsections of the xref.""" for start, size in self._pairs(idx_pairs): # The subsections must increase for num in range(start, start + size): # The first entry is the type xref_type = get_entry(0) # The rest of the elements depend on the xref_type if xref_type == 0: # linked list of free objects next_free_object = get_entry(1) # noqa: F841 next_generation = get_entry(2) # noqa: F841 elif xref_type == 1: # objects that are in use but are not compressed byte_offset = get_entry(1) generation = get_entry(2) if generation not in self.xref: self.xref[generation] = {} # type: ignore if not used_before(num, generation): self.xref[generation][num] = byte_offset # type: ignore elif xref_type == 2: # compressed objects objstr_num = get_entry(1) obstr_idx = get_entry(2) generation = 0 # PDF spec table 18, generation is 0 if not used_before(num, generation): self.xref_objStm[num] = (objstr_num, obstr_idx) elif self.strict: raise PdfReadError(f"Unknown xref type: {xref_type}") def _pairs(self, array: list[int]) -> Iterable[tuple[int, int]]: """Iterate over pairs in the array.""" i = 0 while i + 1 < len(array): yield array[i], array[i + 1] i += 2 def decrypt(self, password: Union[str, bytes]) -> PasswordType: """ When using an encrypted / secured PDF file with the PDF Standard encryption handler, this function will allow the file to be decrypted. It checks the given password against the document's user password and owner password, and then stores the resulting decryption key if either password is correct. It does not matter which password was matched. Both passwords provide the correct decryption key that will allow the document to be used with this library. Args: password: The password to match. Returns: An indicator if the document was decrypted and whether it was the owner password or the user password. """ if not self._encryption: raise PdfReadError("Not encrypted file") # TODO: raise Exception for wrong password return self._encryption.verify(password) @property def is_encrypted(self) -> bool: """ Read-only boolean property showing whether this PDF file is encrypted. Note that this property, if true, will remain true even after the :meth:`decrypt()` method is called. """ return TK.ENCRYPT in self.trailer def add_form_topname(self, name: str) -> Optional[DictionaryObject]: """ Add a top level form that groups all form fields below it. Args: name: text string of the "/T" Attribute of the created object Returns: The created object. ``None`` means no object was created. """ catalog = self.root_object if "/AcroForm" not in catalog or not isinstance( catalog["/AcroForm"], DictionaryObject ): return None acroform = cast(DictionaryObject, catalog[NameObject("/AcroForm")]) if "/Fields" not in acroform: # TODO: No error but this may be extended for XFA Forms return None interim = DictionaryObject() interim[NameObject("/T")] = TextStringObject(name) interim[NameObject("/Kids")] = acroform[NameObject("/Fields")] self.cache_indirect_object( 0, max(i for (g, i) in self.resolved_objects if g == 0) + 1, interim, ) arr = ArrayObject() arr.append(interim.indirect_reference) acroform[NameObject("/Fields")] = arr for o in cast(ArrayObject, interim["/Kids"]): obj = o.get_object() if "/Parent" in obj: logger_warning( f"Top Level Form Field {obj.indirect_reference} have a non-expected parent", __name__, ) obj[NameObject("/Parent")] = interim.indirect_reference return interim def rename_form_topname(self, name: str) -> Optional[DictionaryObject]: """ Rename top level form field that all form fields below it. Args: name: text string of the "/T" field of the created object Returns: The modified object. ``None`` means no object was modified. """ catalog = self.root_object if "/AcroForm" not in catalog or not isinstance( catalog["/AcroForm"], DictionaryObject ): return None acroform = cast(DictionaryObject, catalog[NameObject("/AcroForm")]) if "/Fields" not in acroform: return None interim = cast( DictionaryObject, cast(ArrayObject, acroform[NameObject("/Fields")])[0].get_object(), ) interim[NameObject("/T")] = TextStringObject(name) return interim def _repr_mimebundle_( self, include: Union[None, Iterable[str]] = None, exclude: Union[None, Iterable[str]] = None, ) -> dict[str, Any]: """ Integration into Jupyter Notebooks. This method returns a dictionary that maps a mime-type to its representation. .. seealso:: https://ipython.readthedocs.io/en/stable/config/integrating.html """ self.stream.seek(0) pdf_data = self.stream.read() data = { "application/pdf": pdf_data, } if include is not None: # Filter representations based on include list data = {k: v for k, v in data.items() if k in include} if exclude is not None: # Remove representations based on exclude list data = {k: v for k, v in data.items() if k not in exclude} return data pypdf-6.1.2/pypdf/_text_extraction/000077500000000000000000000000001507516550200173555ustar00rootroot00000000000000pypdf-6.1.2/pypdf/_text_extraction/__init__.py000066400000000000000000000205071507516550200214720ustar00rootroot00000000000000""" Code related to text extraction. Some parts are still in _page.py. In doubt, they will stay there. """ import math from typing import Any, Callable, Optional, Union from ..generic import DictionaryObject, TextStringObject, encode_pdfdocencoding CUSTOM_RTL_MIN: int = -1 CUSTOM_RTL_MAX: int = -1 CUSTOM_RTL_SPECIAL_CHARS: list[int] = [] LAYOUT_NEW_BT_GROUP_SPACE_WIDTHS: int = 5 class OrientationNotFoundError(Exception): pass def set_custom_rtl( _min: Union[str, int, None] = None, _max: Union[str, int, None] = None, specials: Union[str, list[int], None] = None, ) -> tuple[int, int, list[int]]: """ Change the Right-To-Left and special characters custom parameters. Args: _min: The new minimum value for the range of custom characters that will be written right to left. If set to ``None``, the value will not be changed. If set to an integer or string, it will be converted to its ASCII code. The default value is -1, which sets no additional range to be converted. _max: The new maximum value for the range of custom characters that will be written right to left. If set to ``None``, the value will not be changed. If set to an integer or string, it will be converted to its ASCII code. The default value is -1, which sets no additional range to be converted. specials: The new list of special characters to be inserted in the current insertion order. If set to ``None``, the current value will not be changed. If set to a string, it will be converted to a list of ASCII codes. The default value is an empty list. Returns: A tuple containing the new values for ``CUSTOM_RTL_MIN``, ``CUSTOM_RTL_MAX``, and ``CUSTOM_RTL_SPECIAL_CHARS``. """ global CUSTOM_RTL_MIN, CUSTOM_RTL_MAX, CUSTOM_RTL_SPECIAL_CHARS if isinstance(_min, int): CUSTOM_RTL_MIN = _min elif isinstance(_min, str): CUSTOM_RTL_MIN = ord(_min) if isinstance(_max, int): CUSTOM_RTL_MAX = _max elif isinstance(_max, str): CUSTOM_RTL_MAX = ord(_max) if isinstance(specials, str): CUSTOM_RTL_SPECIAL_CHARS = [ord(x) for x in specials] elif isinstance(specials, list): CUSTOM_RTL_SPECIAL_CHARS = specials return CUSTOM_RTL_MIN, CUSTOM_RTL_MAX, CUSTOM_RTL_SPECIAL_CHARS def mult(m: list[float], n: list[float]) -> list[float]: return [ m[0] * n[0] + m[1] * n[2], m[0] * n[1] + m[1] * n[3], m[2] * n[0] + m[3] * n[2], m[2] * n[1] + m[3] * n[3], m[4] * n[0] + m[5] * n[2] + n[4], m[4] * n[1] + m[5] * n[3] + n[5], ] def orient(m: list[float]) -> int: if m[3] > 1e-6: return 0 if m[3] < -1e-6: return 180 if m[1] > 0: return 90 return 270 def crlf_space_check( text: str, cmtm_prev: tuple[list[float], list[float]], cmtm_matrix: tuple[list[float], list[float]], memo_cmtm: tuple[list[float], list[float]], cmap: tuple[ Union[str, dict[int, str]], dict[str, str], str, Optional[DictionaryObject] ], orientations: tuple[int, ...], output: str, font_size: float, visitor_text: Optional[Callable[[Any, Any, Any, Any, Any], None]], str_widths: float, spacewidth: float, str_height: float, ) -> tuple[str, str, list[float], list[float]]: cm_prev = cmtm_prev[0] tm_prev = cmtm_prev[1] cm_matrix = cmtm_matrix[0] tm_matrix = cmtm_matrix[1] memo_cm = memo_cmtm[0] memo_tm = memo_cmtm[1] m_prev = mult(tm_prev, cm_prev) m = mult(tm_matrix, cm_matrix) orientation = orient(m) delta_x = m[4] - m_prev[4] delta_y = m[5] - m_prev[5] # Table 108 of the 1.7 reference ("Text positioning operators") scale_prev_x = math.sqrt(tm_prev[0]**2 + tm_prev[1]**2) scale_prev_y = math.sqrt(tm_prev[2]**2 + tm_prev[3]**2) scale_y = math.sqrt(tm_matrix[2]**2 + tm_matrix[3]**2) cm_prev = m if orientation not in orientations: raise OrientationNotFoundError if orientation in (0, 180): moved_height: float = delta_y moved_width: float = delta_x elif orientation in (90, 270): moved_height = delta_x moved_width = delta_y try: if abs(moved_height) > 0.8 * min(str_height * scale_prev_y, font_size * scale_y): if (output + text)[-1] != "\n": output += text + "\n" if visitor_text is not None: visitor_text( text + "\n", memo_cm, memo_tm, cmap[3], font_size, ) text = "" elif ( (moved_width >= (spacewidth + str_widths) * scale_prev_x) and (output + text)[-1] != " " ): text += " " except Exception: pass tm_prev = tm_matrix.copy() cm_prev = cm_matrix.copy() return text, output, cm_prev, tm_prev def get_text_operands( operands: list[Union[str, TextStringObject]], cm_matrix: list[float], tm_matrix: list[float], cmap: tuple[ Union[str, dict[int, str]], dict[str, str], str, Optional[DictionaryObject] ], orientations: tuple[int, ...] ) -> tuple[str, bool]: t: str = "" is_str_operands = False m = mult(tm_matrix, cm_matrix) orientation = orient(m) if orientation in orientations and len(operands) > 0: if isinstance(operands[0], str): t = operands[0] is_str_operands = True else: t = "" tt: bytes = ( encode_pdfdocencoding(operands[0]) if isinstance(operands[0], str) else operands[0] ) if isinstance(cmap[0], str): try: t = tt.decode(cmap[0], "surrogatepass") # apply str encoding except Exception: # the data does not match the expectation, # we use the alternative ; # text extraction may not be good t = tt.decode( "utf-16-be" if cmap[0] == "charmap" else "charmap", "surrogatepass", ) # apply str encoding else: # apply dict encoding t = "".join( [cmap[0][x] if x in cmap[0] else bytes((x,)).decode() for x in tt] ) return (t, is_str_operands) def get_display_str( text: str, cm_matrix: list[float], tm_matrix: list[float], cmap: tuple[ Union[str, dict[int, str]], dict[str, str], str, Optional[DictionaryObject] ], text_operands: str, font_size: float, rtl_dir: bool, visitor_text: Optional[Callable[[Any, Any, Any, Any, Any], None]] ) -> tuple[str, bool]: # "\u0590 - \u08FF \uFB50 - \uFDFF" for x in [cmap[1].get(x, x) for x in text_operands]: # x can be a sequence of bytes ; ex: habibi.pdf if len(x) == 1: xx = ord(x) else: xx = 1 # fmt: off if ( # cases where the current inserting order is kept (xx <= 0x2F) # punctuations but... or 0x3A <= xx <= 0x40 # numbers (x30-39) or 0x2000 <= xx <= 0x206F # upper punctuations.. or 0x20A0 <= xx <= 0x21FF # but (numbers) indices/exponents or xx in CUSTOM_RTL_SPECIAL_CHARS # customized.... ): text = x + text if rtl_dir else text + x elif ( # right-to-left characters set 0x0590 <= xx <= 0x08FF or 0xFB1D <= xx <= 0xFDFF or 0xFE70 <= xx <= 0xFEFF or CUSTOM_RTL_MIN <= xx <= CUSTOM_RTL_MAX ): if not rtl_dir: rtl_dir = True if visitor_text is not None: visitor_text(text, cm_matrix, tm_matrix, cmap[3], font_size) text = "" text = x + text else: # left-to-right if rtl_dir: rtl_dir = False if visitor_text is not None: visitor_text(text, cm_matrix, tm_matrix, cmap[3], font_size) text = "" text = text + x # fmt: on return text, rtl_dir pypdf-6.1.2/pypdf/_text_extraction/_layout_mode/000077500000000000000000000000001507516550200220355ustar00rootroot00000000000000pypdf-6.1.2/pypdf/_text_extraction/_layout_mode/__init__.py000066400000000000000000000005221507516550200241450ustar00rootroot00000000000000"""Layout mode text extraction extension for pypdf""" from ._fixed_width_page import ( fixed_char_width, fixed_width_page, text_show_operations, y_coordinate_groups, ) from ._font import Font __all__ = [ "Font", "fixed_char_width", "fixed_width_page", "text_show_operations", "y_coordinate_groups", ] pypdf-6.1.2/pypdf/_text_extraction/_layout_mode/_fixed_width_page.py000066400000000000000000000351131507516550200260430ustar00rootroot00000000000000"""Extract PDF text preserving the layout of the source PDF""" from collections.abc import Iterator from itertools import groupby from math import ceil from pathlib import Path from typing import Any, Literal, Optional, TypedDict from ..._utils import logger_warning from .. import LAYOUT_NEW_BT_GROUP_SPACE_WIDTHS from ._font import Font from ._text_state_manager import TextStateManager from ._text_state_params import TextStateParams class BTGroup(TypedDict): """ Dict describing a line of text rendered within a BT/ET operator pair. If multiple text show operations render text on the same line, the text will be combined into a single BTGroup dict. Keys: tx: x coordinate of first character in BTGroup ty: y coordinate of first character in BTGroup font_size: nominal font size font_height: effective font height text: rendered text displaced_tx: x coordinate of last character in BTGroup flip_sort: -1 if page is upside down, else 1 """ tx: float ty: float font_size: float font_height: float text: str displaced_tx: float flip_sort: Literal[-1, 1] def bt_group(tj_op: TextStateParams, rendered_text: str, dispaced_tx: float) -> BTGroup: """ BTGroup constructed from a TextStateParams instance, rendered text, and displaced tx value. Args: tj_op (TextStateParams): TextStateParams instance rendered_text (str): rendered text dispaced_tx (float): x coordinate of last character in BTGroup """ return BTGroup( tx=tj_op.tx, ty=tj_op.ty, font_size=tj_op.font_size, font_height=tj_op.font_height, text=rendered_text, displaced_tx=dispaced_tx, flip_sort=-1 if tj_op.flip_vertical else 1, ) def recurs_to_target_op( ops: Iterator[tuple[list[Any], bytes]], text_state_mgr: TextStateManager, end_target: Literal[b"Q", b"ET"], fonts: dict[str, Font], strip_rotated: bool = True, ) -> tuple[list[BTGroup], list[TextStateParams]]: """ Recurse operators between BT/ET and/or q/Q operators managing the transform stack and capturing text positioning and rendering data. Args: ops: iterator of operators in content stream text_state_mgr: a TextStateManager instance end_target: Either b"Q" (ends b"q" op) or b"ET" (ends b"BT" op) fonts: font dictionary as returned by PageObject._layout_mode_fonts() Returns: tuple: list of BTGroup dicts + list of TextStateParams dataclass instances. """ # 1 entry per line of text rendered within each BT/ET operation. bt_groups: list[BTGroup] = [] # 1 entry per text show operator (Tj/TJ/'/") tj_ops: list[TextStateParams] = [] if end_target == b"Q": # add new q level. cm's added at this level will be popped at next b'Q' text_state_mgr.add_q() for operands, op in ops: # The loop is broken by the end target, or exits normally when there are no more ops. if op == end_target: if op == b"Q": text_state_mgr.remove_q() if op == b"ET": if not tj_ops: return bt_groups, tj_ops _text = "" bt_idx = 0 # idx of first tj in this bt group last_displaced_tx = tj_ops[bt_idx].displaced_tx last_ty = tj_ops[bt_idx].ty for _idx, _tj in enumerate( tj_ops ): # ... build text from new Tj operators if strip_rotated and _tj.rotated: continue if not _tj.font.interpretable: # generates warning continue # if the y position of the text is greater than the font height, assume # the text is on a new line and start a new group if abs(_tj.ty - last_ty) > _tj.font_height: if _text.strip(): bt_groups.append( bt_group(tj_ops[bt_idx], _text, last_displaced_tx) ) bt_idx = _idx _text = "" # if the x position of the text is less than the last x position by # more than 5 spaces widths, assume the text order should be flipped # and start a new group if ( last_displaced_tx - _tj.tx > _tj.space_tx * LAYOUT_NEW_BT_GROUP_SPACE_WIDTHS ): if _text.strip(): bt_groups.append( bt_group(tj_ops[bt_idx], _text, last_displaced_tx) ) bt_idx = _idx last_displaced_tx = _tj.displaced_tx _text = "" # calculate excess x translation based on ending tx of previous Tj. # multiply by bool (_idx != bt_idx) to ensure spaces aren't double # applied to the first tj of a BTGroup in fixed_width_page(). excess_tx = round(_tj.tx - last_displaced_tx, 3) * (_idx != bt_idx) # space_tx could be 0 if either Tz or font_size was 0 for this _tj. spaces = int(excess_tx // _tj.space_tx) if _tj.space_tx else 0 new_text = f'{" " * spaces}{_tj.txt}' last_ty = _tj.ty _text = f"{_text}{new_text}" last_displaced_tx = _tj.displaced_tx if _text: bt_groups.append(bt_group(tj_ops[bt_idx], _text, last_displaced_tx)) text_state_mgr.reset_tm() break if op == b"q": bts, tjs = recurs_to_target_op( ops, text_state_mgr, b"Q", fonts, strip_rotated ) bt_groups.extend(bts) tj_ops.extend(tjs) elif op == b"cm": text_state_mgr.add_cm(*operands) elif op == b"BT": bts, tjs = recurs_to_target_op( ops, text_state_mgr, b"ET", fonts, strip_rotated ) bt_groups.extend(bts) tj_ops.extend(tjs) elif op == b"Tj": tj_ops.append(text_state_mgr.text_state_params(operands[0])) elif op == b"TJ": _tj = text_state_mgr.text_state_params() for tj_op in operands[0]: if isinstance(tj_op, bytes): _tj = text_state_mgr.text_state_params(tj_op) tj_ops.append(_tj) else: text_state_mgr.add_trm(_tj.displacement_matrix(TD_offset=tj_op)) elif op == b"'": text_state_mgr.reset_trm() text_state_mgr.add_tm([0, -text_state_mgr.TL]) tj_ops.append(text_state_mgr.text_state_params(operands[0])) elif op == b'"': text_state_mgr.reset_trm() text_state_mgr.set_state_param(b"Tw", operands[0]) text_state_mgr.set_state_param(b"Tc", operands[1]) text_state_mgr.add_tm([0, -text_state_mgr.TL]) tj_ops.append(text_state_mgr.text_state_params(operands[2])) elif op in (b"Td", b"Tm", b"TD", b"T*"): text_state_mgr.reset_trm() if op == b"Tm": text_state_mgr.reset_tm() elif op == b"TD": text_state_mgr.set_state_param(b"TL", -operands[1]) elif op == b"T*": operands = [0, -text_state_mgr.TL] text_state_mgr.add_tm(operands) elif op == b"Tf": text_state_mgr.set_font(fonts[operands[0]], operands[1]) else: # handle Tc, Tw, Tz, TL, and Ts operators text_state_mgr.set_state_param(op, operands) else: logger_warning( f"Unbalanced target operations, expected {end_target!r}.", __name__, ) return bt_groups, tj_ops def y_coordinate_groups( bt_groups: list[BTGroup], debug_path: Optional[Path] = None ) -> dict[int, list[BTGroup]]: """ Group text operations by rendered y coordinate, i.e. the line number. Args: bt_groups: list of dicts as returned by text_show_operations() debug_path (Path, optional): Path to a directory for saving debug output. Returns: Dict[int, List[BTGroup]]: dict of lists of text rendered by each BT operator keyed by y coordinate """ ty_groups = { ty: sorted(grp, key=lambda x: x["tx"]) for ty, grp in groupby( bt_groups, key=lambda bt_grp: int(bt_grp["ty"] * bt_grp["flip_sort"]) ) } # combine groups whose y coordinates differ by less than the effective font height # (accounts for mixed fonts and other minor oddities) last_ty = next(iter(ty_groups)) last_txs = {int(_t["tx"]) for _t in ty_groups[last_ty] if _t["text"].strip()} for ty in list(ty_groups)[1:]: fsz = min(ty_groups[_y][0]["font_height"] for _y in (ty, last_ty)) txs = {int(_t["tx"]) for _t in ty_groups[ty] if _t["text"].strip()} # prevent merge if both groups are rendering in the same x position. no_text_overlap = not (txs & last_txs) offset_less_than_font_height = abs(ty - last_ty) < fsz if no_text_overlap and offset_less_than_font_height: ty_groups[last_ty] = sorted( ty_groups.pop(ty) + ty_groups[last_ty], key=lambda x: x["tx"] ) last_txs |= txs else: last_ty = ty last_txs = txs if debug_path: # pragma: no cover import json # noqa: PLC0415 debug_path.joinpath("bt_groups.json").write_text( json.dumps(ty_groups, indent=2, default=str), "utf-8" ) return ty_groups def text_show_operations( ops: Iterator[tuple[list[Any], bytes]], fonts: dict[str, Font], strip_rotated: bool = True, debug_path: Optional[Path] = None, ) -> list[BTGroup]: """ Extract text from BT/ET operator pairs. Args: ops (Iterator[Tuple[List, bytes]]): iterator of operators in content stream fonts (Dict[str, Font]): font dictionary strip_rotated: Removes text if rotated w.r.t. to the page. Defaults to True. debug_path (Path, optional): Path to a directory for saving debug output. Returns: List[BTGroup]: list of dicts of text rendered by each BT operator """ state_mgr = TextStateManager() # transformation stack manager bt_groups: list[BTGroup] = [] # BT operator dict tj_ops: list[TextStateParams] = [] # Tj/TJ operator data for operands, op in ops: if op in (b"BT", b"q"): bts, tjs = recurs_to_target_op( ops, state_mgr, b"ET" if op == b"BT" else b"Q", fonts, strip_rotated ) bt_groups.extend(bts) tj_ops.extend(tjs) elif op == b"Tf": state_mgr.set_font(fonts[operands[0]], operands[1]) else: # set Tc, Tw, Tz, TL, and Ts if required. ignores all other ops state_mgr.set_state_param(op, operands) if any(tj.rotated for tj in tj_ops): if strip_rotated: logger_warning( "Rotated text discovered. Output will be incomplete.", __name__ ) else: logger_warning( "Rotated text discovered. Layout will be degraded.", __name__ ) if not all(tj.font.interpretable for tj in tj_ops): logger_warning( "PDF contains an uninterpretable font. Output will be incomplete.", __name__ ) # left align the data, i.e. decrement all tx values by min(tx) min_x = min((x["tx"] for x in bt_groups), default=0.0) bt_groups = [ dict(ogrp, tx=ogrp["tx"] - min_x, displaced_tx=ogrp["displaced_tx"] - min_x) # type: ignore[misc] for ogrp in sorted( bt_groups, key=lambda x: (x["ty"] * x["flip_sort"], -x["tx"]), reverse=True ) ] if debug_path: # pragma: no cover import json # noqa: PLC0415 debug_path.joinpath("bts.json").write_text( json.dumps(bt_groups, indent=2, default=str), "utf-8" ) debug_path.joinpath("tjs.json").write_text( json.dumps( tj_ops, indent=2, default=lambda x: getattr(x, "to_dict", str)(x) ), "utf-8", ) return bt_groups def fixed_char_width(bt_groups: list[BTGroup], scale_weight: float = 1.25) -> float: """ Calculate average character width weighted by the length of the rendered text in each sample for conversion to fixed-width layout. Args: bt_groups (List[BTGroup]): List of dicts of text rendered by each BT operator Returns: float: fixed character width """ char_widths = [] for _bt in bt_groups: _len = len(_bt["text"]) * scale_weight char_widths.append(((_bt["displaced_tx"] - _bt["tx"]) / _len, _len)) return sum(_w * _l for _w, _l in char_widths) / sum(_l for _, _l in char_widths) def fixed_width_page( ty_groups: dict[int, list[BTGroup]], char_width: float, space_vertically: bool, font_height_weight: float ) -> str: """ Generate page text from text operations grouped by rendered y coordinate. Args: ty_groups: dict of text show ops as returned by y_coordinate_groups() char_width: fixed character width space_vertically: include blank lines inferred from y distance + font height. font_height_weight: multiplier for font height when calculating blank lines. Returns: str: page text in a fixed width format that closely adheres to the rendered layout in the source pdf. """ lines: list[str] = [] last_y_coord = 0 for y_coord, line_data in ty_groups.items(): if space_vertically and lines: fh = line_data[0]["font_height"] blank_lines = 0 if fh == 0 else ( int(abs(y_coord - last_y_coord) / (fh * font_height_weight)) - 1 ) lines.extend([""] * blank_lines) line = "" last_disp = 0.0 for bt_op in line_data: offset = int(bt_op["tx"] // char_width) spaces = (offset - len(line)) * (ceil(last_disp) < int(bt_op["tx"])) line = f"{line}{' ' * spaces}{bt_op['text']}" last_disp = bt_op["displaced_tx"] if line.strip() or lines: lines.append( "".join(c if ord(c) < 14 or ord(c) > 31 else " " for c in line) ) last_y_coord = y_coord return "\n".join(ln.rstrip() for ln in lines if space_vertically or ln.strip()) pypdf-6.1.2/pypdf/_text_extraction/_layout_mode/_font.py000066400000000000000000000156341507516550200235250ustar00rootroot00000000000000"""Font constants and classes for "layout" mode text operations""" from collections.abc import Sequence from dataclasses import dataclass, field from typing import Any, Union, cast from ..._codecs import adobe_glyphs from ...errors import ParseError from ...generic import IndirectObject from ._font_widths import STANDARD_WIDTHS @dataclass class Font: """ A font object formatted for use during "layout" mode text extraction Attributes: subtype (str): font subtype space_width (int | float): width of a space character encoding (str | Dict[int, str]): font encoding char_map (dict): character map font_dictionary (dict): font dictionary width_map (Dict[str, int]): mapping of characters to widths interpretable (bool): Default True. If False, the font glyphs cannot be translated to characters, e.g. Type3 fonts that do not define a '/ToUnicode' mapping. """ subtype: str space_width: Union[int, float] encoding: Union[str, dict[int, str]] char_map: dict[Any, Any] font_dictionary: dict[Any, Any] width_map: dict[str, int] = field(default_factory=dict, init=False) interpretable: bool = True def __post_init__(self) -> None: # Type3 fonts that do not specify a "/ToUnicode" mapping cannot be # reliably converted into character codes unless all named chars # in /CharProcs map to a standard adobe glyph. See §9.10.2 of the # PDF 1.7 standard. if self.subtype == "/Type3" and "/ToUnicode" not in self.font_dictionary: self.interpretable = all( cname in adobe_glyphs for cname in self.font_dictionary.get("/CharProcs") or [] ) if not self.interpretable: # save some overhead if font is not interpretable return # TrueType fonts have a /Widths array mapping character codes to widths if isinstance(self.encoding, dict) and "/Widths" in self.font_dictionary: first_char = self.font_dictionary.get("/FirstChar", 0) self.width_map = { self.encoding.get(idx + first_char, chr(idx + first_char)): width for idx, width in enumerate(self.font_dictionary["/Widths"]) } # CID fonts have a /W array mapping character codes to widths stashed in /DescendantFonts if "/DescendantFonts" in self.font_dictionary: d_font: dict[Any, Any] for d_font_idx, d_font in enumerate( self.font_dictionary["/DescendantFonts"] ): while isinstance(d_font, IndirectObject): d_font = d_font.get_object() self.font_dictionary["/DescendantFonts"][d_font_idx] = d_font ord_map = { ord(_target): _surrogate for _target, _surrogate in self.char_map.items() if isinstance(_target, str) } # /W width definitions have two valid formats which can be mixed and matched: # (1) A character start index followed by a list of widths, e.g. # `45 [500 600 700]` applies widths 500, 600, 700 to characters 45-47. # (2) A character start index, a character stop index, and a width, e.g. # `45 65 500` applies width 500 to characters 45-65. skip_count = 0 _w = d_font.get("/W", []) for idx, w_entry in enumerate(_w): w_entry = w_entry.get_object() if skip_count: skip_count -= 1 continue if not isinstance(w_entry, (int, float)): # pragma: no cover # We should never get here due to skip_count above. Add a # warning and or use reader's "strict" to force an ex??? continue # check for format (1): `int [int int int int ...]` w_next_entry = _w[idx + 1].get_object() if isinstance(w_next_entry, Sequence): start_idx, width_list = w_entry, w_next_entry self.width_map.update( { ord_map[_cidx]: _width for _cidx, _width in zip( range( cast(int, start_idx), cast(int, start_idx) + len(width_list), 1, ), width_list, ) if _cidx in ord_map } ) skip_count = 1 # check for format (2): `int int int` elif isinstance(w_next_entry, (int, float)) and isinstance( _w[idx + 2].get_object(), (int, float) ): start_idx, stop_idx, const_width = ( w_entry, w_next_entry, _w[idx + 2].get_object(), ) self.width_map.update( { ord_map[_cidx]: const_width for _cidx in range( cast(int, start_idx), cast(int, stop_idx + 1), 1 ) if _cidx in ord_map } ) skip_count = 2 else: # Note: this doesn't handle the case of out of bounds (reaching the end of the width definitions # while expecting more elements). This raises an IndexError which is sufficient. raise ParseError( f"Invalid font width definition. Next elements: {w_entry}, {w_next_entry}, {_w[idx + 2]}" ) # pragma: no cover if not self.width_map and "/BaseFont" in self.font_dictionary: for key in STANDARD_WIDTHS: if self.font_dictionary["/BaseFont"].startswith(f"/{key}"): self.width_map = STANDARD_WIDTHS[key] break def word_width(self, word: str) -> float: """Sum of character widths specified in PDF font for the supplied word""" return sum( [self.width_map.get(char, self.space_width * 2) for char in word], 0.0 ) @staticmethod def to_dict(font_instance: "Font") -> dict[str, Any]: """Dataclass to dict for json.dumps serialization.""" return { k: getattr(font_instance, k) for k in font_instance.__dataclass_fields__ } pypdf-6.1.2/pypdf/_text_extraction/_layout_mode/_font_widths.py000066400000000000000000000102511507516550200250750ustar00rootroot00000000000000# Widths for the standard 14 fonts as described on page 416 of the PDF 1.7 standard STANDARD_WIDTHS = { "Helvetica": { # 4 fonts, includes bold, oblique and boldoblique variants " ": 278, "!": 278, '"': 355, "#": 556, "$": 556, "%": 889, "&": 667, "'": 191, "(": 333, ")": 333, "*": 389, "+": 584, ",": 278, "-": 333, ".": 278, "/": 278, "0": 556, "1": 556, "2": 556, "3": 556, "4": 556, "5": 556, "6": 556, "7": 556, "8": 556, "9": 556, ":": 278, ";": 278, "<": 584, "=": 584, ">": 584, "?": 611, "@": 975, "A": 667, "B": 667, "C": 722, "D": 722, "E": 667, "F": 611, "G": 778, "H": 722, "I": 278, "J": 500, "K": 667, "L": 556, "M": 833, "N": 722, "O": 778, "P": 667, "Q": 944, "R": 667, "S": 667, "T": 611, "U": 278, "V": 278, "W": 584, "X": 556, "Y": 556, "Z": 500, "[": 556, "\\": 556, "]": 556, "^": 278, "_": 278, "`": 278, "a": 278, "b": 278, "c": 333, "d": 556, "e": 556, "f": 556, "g": 556, "h": 556, "i": 556, "j": 556, "k": 556, "l": 556, "m": 556, "n": 278, "o": 278, "p": 556, "q": 556, "r": 500, "s": 556, "t": 556, "u": 278, "v": 500, "w": 500, "x": 222, "y": 222, "z": 556, "{": 222, "|": 833, "}": 556, "~": 556, }, "Times": { # 4 fonts, includes bold, oblique and boldoblique variants " ": 250, "!": 333, '"': 408, "#": 500, "$": 500, "%": 833, "&": 778, "'": 180, "(": 333, ")": 333, "*": 500, "+": 564, ",": 250, "-": 333, ".": 250, "/": 564, "0": 500, "1": 500, "2": 500, "3": 500, "4": 500, "5": 500, "6": 500, "7": 500, "8": 500, "9": 500, ":": 278, ";": 278, "<": 564, "=": 564, ">": 564, "?": 444, "@": 921, "A": 722, "B": 667, "C": 667, "D": 722, "E": 611, "F": 556, "G": 722, "H": 722, "I": 333, "J": 389, "K": 722, "L": 611, "M": 889, "N": 722, "O": 722, "P": 556, "Q": 722, "R": 667, "S": 556, "T": 611, "U": 722, "V": 722, "W": 944, "X": 722, "Y": 722, "Z": 611, "[": 333, "\\": 278, "]": 333, "^": 469, "_": 500, "`": 333, "a": 444, "b": 500, "c": 444, "d": 500, "e": 444, "f": 333, "g": 500, "h": 500, "i": 278, "j": 278, "k": 500, "l": 278, "m": 722, "n": 500, "o": 500, "p": 500, "q": 500, "r": 333, "s": 389, "t": 278, "u": 500, "v": 444, "w": 722, "x": 500, "y": 444, "z": 389, "{": 348, "|": 220, "}": 348, "~": 469, }, } # 4 fonts, includes bold, oblique and bold oblique variants STANDARD_WIDTHS[ "Courier" ] = dict.fromkeys(STANDARD_WIDTHS["Times"], 600) # fixed width STANDARD_WIDTHS["ZapfDingbats"] = dict.fromkeys(STANDARD_WIDTHS["Times"], 1000) # 1 font STANDARD_WIDTHS["Symbol"] = dict.fromkeys(STANDARD_WIDTHS["Times"], 500) # 1 font # add aliases per table H.3 on page 1110 of the PDF 1.7 standard STANDARD_WIDTHS["CourierNew"] = STANDARD_WIDTHS["Courier"] STANDARD_WIDTHS["Arial"] = STANDARD_WIDTHS["Helvetica"] STANDARD_WIDTHS["TimesNewRoman"] = STANDARD_WIDTHS["Times"] pypdf-6.1.2/pypdf/_text_extraction/_layout_mode/_text_state_manager.py000066400000000000000000000200261507516550200264240ustar00rootroot00000000000000"""manage the PDF transform stack during "layout" mode text extraction""" from collections import ChainMap, Counter from collections import ChainMap as ChainMapType from collections import Counter as CounterType from collections.abc import MutableMapping from typing import Any, Union from ...errors import PdfReadError from .. import mult from ._font import Font from ._text_state_params import TextStateParams TextStateManagerChainMapType = ChainMapType[Union[int, str], Union[float, bool]] TextStateManagerDictType = MutableMapping[Union[int, str], Union[float, bool]] class TextStateManager: """ Tracks the current text state including cm/tm/trm transformation matrices. Attributes: transform_stack (ChainMap): ChainMap of cm/tm transformation matrices q_queue (Counter[int]): Counter of q operators q_depth (List[int]): list of q operator nesting levels Tc (float): character spacing Tw (float): word spacing Tz (int): horizontal scaling TL (float): leading Ts (float): text rise font (Font): font object font_size (int | float): font size """ def __init__(self) -> None: self.transform_stack: TextStateManagerChainMapType = ChainMap( self.new_transform() ) self.q_queue: CounterType[int] = Counter() self.q_depth = [0] self.Tc: float = 0.0 self.Tw: float = 0.0 self.Tz: float = 100.0 self.TL: float = 0.0 self.Ts: float = 0.0 self.font_stack: list[tuple[Union[Font, None], Union[int, float]]] = [] self.font: Union[Font, None] = None self.font_size: Union[int, float] = 0 def set_state_param(self, op: bytes, value: Union[float, list[Any]]) -> None: """ Set a text state parameter. Supports Tc, Tz, Tw, TL, and Ts operators. Args: op: operator read from PDF stream as bytes. No action is taken for unsupported operators (see supported operators above). value (float | List[Any]): new parameter value. If a list, value[0] is used. """ if op not in [b"Tc", b"Tz", b"Tw", b"TL", b"Ts"]: return self.__setattr__(op.decode(), value[0] if isinstance(value, list) else value) def set_font(self, font: Font, size: float) -> None: """ Set the current font and font_size. Args: font (Font): a layout mode Font size (float): font size """ self.font = font self.font_size = size def text_state_params(self, value: Union[bytes, str] = "") -> TextStateParams: """ Create a TextStateParams instance to display a text string. Type[bytes] values will be decoded implicitly. Args: value (str | bytes): text to associate with the captured state. Raises: PdfReadError: if font not set (no Tf operator in incoming pdf content stream) Returns: TextStateParams: current text state parameters """ if not isinstance(self.font, Font): raise PdfReadError( "font not set: is PDF missing a Tf operator?" ) # pragma: no cover if isinstance(value, bytes): try: if isinstance(self.font.encoding, str): txt = value.decode(self.font.encoding, "surrogatepass") else: txt = "".join( self.font.encoding[x] if x in self.font.encoding else bytes((x,)).decode() for x in value ) except (UnicodeEncodeError, UnicodeDecodeError): txt = value.decode("utf-8", "replace") txt = "".join( self.font.char_map.get(x, x) for x in txt ) else: txt = value return TextStateParams( txt, self.font, self.font_size, self.Tc, self.Tw, self.Tz, self.TL, self.Ts, self.effective_transform, ) @staticmethod def raw_transform( _a: float = 1.0, _b: float = 0.0, _c: float = 0.0, _d: float = 1.0, _e: float = 0.0, _f: float = 0.0, ) -> dict[int, float]: """Only a/b/c/d/e/f matrix params""" return dict(zip(range(6), map(float, (_a, _b, _c, _d, _e, _f)))) @staticmethod def new_transform( _a: float = 1.0, _b: float = 0.0, _c: float = 0.0, _d: float = 1.0, _e: float = 0.0, _f: float = 0.0, is_text: bool = False, is_render: bool = False, ) -> TextStateManagerDictType: """Standard a/b/c/d/e/f matrix params + 'is_text' and 'is_render' keys""" result: Any = TextStateManager.raw_transform(_a, _b, _c, _d, _e, _f) result.update({"is_text": is_text, "is_render": is_render}) return result def reset_tm(self) -> TextStateManagerChainMapType: """Clear all transforms from chainmap having is_text==True or is_render==True""" while ( self.transform_stack.maps[0]["is_text"] or self.transform_stack.maps[0]["is_render"] ): self.transform_stack = self.transform_stack.parents return self.transform_stack def reset_trm(self) -> TextStateManagerChainMapType: """Clear all transforms from chainmap having is_render==True""" while self.transform_stack.maps[0]["is_render"]: self.transform_stack = self.transform_stack.parents return self.transform_stack def remove_q(self) -> TextStateManagerChainMapType: """Rewind to stack prior state after closing a 'q' with internal 'cm' ops""" self.font, self.font_size = self.font_stack.pop(-1) self.transform_stack = self.reset_tm() self.transform_stack.maps = self.transform_stack.maps[ self.q_queue.pop(self.q_depth.pop(), 0) : ] return self.transform_stack def add_q(self) -> None: """Add another level to q_queue""" self.font_stack.append((self.font, self.font_size)) self.q_depth.append(len(self.q_depth)) def add_cm(self, *args: Any) -> TextStateManagerChainMapType: """Concatenate an additional transform matrix""" self.transform_stack = self.reset_tm() self.q_queue.update(self.q_depth[-1:]) self.transform_stack = self.transform_stack.new_child(self.new_transform(*args)) return self.transform_stack def _complete_matrix(self, operands: list[float]) -> list[float]: """Adds a, b, c, and d to an "e/f only" operand set (e.g Td)""" if len(operands) == 2: # this is a Td operator or equivalent operands = [1.0, 0.0, 0.0, 1.0, *operands] return operands def add_tm(self, operands: list[float]) -> TextStateManagerChainMapType: """Append a text transform matrix""" self.transform_stack = self.transform_stack.new_child( self.new_transform( # type: ignore[misc] *self._complete_matrix(operands), is_text=True # type: ignore[arg-type] ) ) return self.transform_stack def add_trm(self, operands: list[float]) -> TextStateManagerChainMapType: """Append a text rendering transform matrix""" self.transform_stack = self.transform_stack.new_child( self.new_transform( # type: ignore[misc] *self._complete_matrix(operands), is_text=True, is_render=True # type: ignore[arg-type] ) ) return self.transform_stack @property def effective_transform(self) -> list[float]: """Current effective transform accounting for cm, tm, and trm transforms""" eff_transform = [*self.transform_stack.maps[0].values()] for transform in self.transform_stack.maps[1:]: eff_transform = mult(eff_transform, transform) # type: ignore[arg-type] # dict has int keys 0-5 return eff_transform pypdf-6.1.2/pypdf/_text_extraction/_layout_mode/_text_state_params.py000066400000000000000000000122721507516550200263010ustar00rootroot00000000000000"""A dataclass that captures the CTM and Text State for a tj operation""" import math from dataclasses import dataclass, field from typing import Any, Union from .. import mult, orient from ._font import Font @dataclass class TextStateParams: """ Text state parameters and operator values for a single text value in a TJ or Tj PDF operation. Attributes: txt (str): the text to be rendered. font (Font): font object font_size (int | float): font size Tc (float): character spacing. Defaults to 0.0. Tw (float): word spacing. Defaults to 0.0. Tz (float): horizontal scaling. Defaults to 100.0. TL (float): leading, vertical displacement between text lines. Defaults to 0.0. Ts (float): text rise. Used for super/subscripts. Defaults to 0.0. transform (List[float]): effective transformation matrix. tx (float): x cood of rendered text, i.e. self.transform[4] ty (float): y cood of rendered text. May differ from self.transform[5] per self.Ts. displaced_tx (float): x coord immediately following rendered text space_tx (float): tx for a space character font_height (float): effective font height accounting for CTM flip_vertical (bool): True if y axis has been inverted (i.e. if self.transform[3] < 0.) rotated (bool): True if the text orientation is rotated with respect to the page. """ txt: str font: Font font_size: Union[int, float] Tc: float = 0.0 Tw: float = 0.0 Tz: float = 100.0 TL: float = 0.0 Ts: float = 0.0 transform: list[float] = field( default_factory=lambda: [1.0, 0.0, 0.0, 1.0, 0.0, 0.0] ) tx: float = field(default=0.0, init=False) ty: float = field(default=0.0, init=False) displaced_tx: float = field(default=0.0, init=False) space_tx: float = field(default=0.0, init=False) font_height: float = field(default=0.0, init=False) flip_vertical: bool = field(default=False, init=False) rotated: bool = field(default=False, init=False) def __post_init__(self) -> None: if orient(self.transform) in (90, 270): self.transform = mult( [1.0, -self.transform[1], -self.transform[2], 1.0, 0.0, 0.0], self.transform, ) self.rotated = True # self.transform[0] AND self.transform[3] < 0 indicates true rotation. # If only self.transform[3] < 0, the y coords are simply inverted. if orient(self.transform) == 180 and self.transform[0] < -1e-6: self.transform = mult([-1.0, 0.0, 0.0, -1.0, 0.0, 0.0], self.transform) self.rotated = True self.displaced_tx = self.displaced_transform()[4] self.tx = self.transform[4] self.ty = self.render_transform()[5] self.space_tx = round(self.word_tx(" "), 3) if self.space_tx < 1e-6: # if the " " char is assigned 0 width (e.g. for fine tuned spacing # with TJ int operators a la crazyones.pdf), calculate space_tx as # a TD_offset of -2 * font.space_width where font.space_width is # the space_width calculated in _cmap.py. self.space_tx = round(self.word_tx("", self.font.space_width * -2), 3) self.font_height = self.font_size * math.sqrt( self.transform[1] ** 2 + self.transform[3] ** 2 ) # flip_vertical handles PDFs generated by Microsoft Word's "publish" command. self.flip_vertical = self.transform[3] < -1e-6 # inverts y axis def font_size_matrix(self) -> list[float]: """Font size matrix""" return [ self.font_size * (self.Tz / 100.0), 0.0, 0.0, self.font_size, 0.0, self.Ts, ] def displaced_transform(self) -> list[float]: """Effective transform matrix after text has been rendered.""" return mult(self.displacement_matrix(), self.transform) def render_transform(self) -> list[float]: """Effective transform matrix accounting for font size, Tz, and Ts.""" return mult(self.font_size_matrix(), self.transform) def displacement_matrix( self, word: Union[str, None] = None, TD_offset: float = 0.0 ) -> list[float]: """ Text displacement matrix Args: word (str, optional): Defaults to None in which case self.txt displacement is returned. TD_offset (float, optional): translation applied by TD operator. Defaults to 0.0. """ word = word if word is not None else self.txt return [1.0, 0.0, 0.0, 1.0, self.word_tx(word, TD_offset), 0.0] def word_tx(self, word: str, TD_offset: float = 0.0) -> float: """Horizontal text displacement for any word according this text state""" return ( (self.font_size * ((self.font.word_width(word) - TD_offset) / 1000.0)) + self.Tc + word.count(" ") * self.Tw ) * (self.Tz / 100.0) @staticmethod def to_dict(inst: "TextStateParams") -> dict[str, Any]: """Dataclass to dict for json.dumps serialization""" return {k: getattr(inst, k) for k in inst.__dataclass_fields__ if k != "font"} pypdf-6.1.2/pypdf/_text_extraction/_text_extractor.py000066400000000000000000000403561507516550200231550ustar00rootroot00000000000000# Copyright (c) 2006, Mathieu Fenniak # Copyright (c) 2007, Ashish Kulkarni # # All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. import math from typing import Any, Callable, Optional, Union from .._cmap import build_font_width_map, compute_font_width, get_actual_str_key from ..generic import DictionaryObject, TextStringObject from . import OrientationNotFoundError, crlf_space_check, get_display_str, get_text_operands, mult class TextExtraction: """ A class to handle PDF text extraction operations. This class encapsulates all the state and operations needed for extracting text from PDF content streams, replacing the nested functions and nonlocal variables in the original implementation. """ def __init__(self) -> None: self._font_width_maps: dict[str, tuple[dict[Any, float], str, float]] = {} # Text extraction state variables self.cm_matrix: list[float] = [1.0, 0.0, 0.0, 1.0, 0.0, 0.0] self.tm_matrix: list[float] = [1.0, 0.0, 0.0, 1.0, 0.0, 0.0] self.cm_stack: list[ tuple[ list[float], tuple[Union[str, dict[int, str]], dict[str, str], str, Optional[DictionaryObject]], float, float, float, float, float, ] ] = [] # Store the last modified matrices; can be an intermediate position self.cm_prev: list[float] = [1.0, 0.0, 0.0, 1.0, 0.0, 0.0] self.tm_prev: list[float] = [1.0, 0.0, 0.0, 1.0, 0.0, 0.0] # Store the position at the beginning of building the text self.memo_cm: list[float] = [1.0, 0.0, 0.0, 1.0, 0.0, 0.0] self.memo_tm: list[float] = [1.0, 0.0, 0.0, 1.0, 0.0, 0.0] self.char_scale = 1.0 self.space_scale = 1.0 self._space_width: float = 500.0 # will be set correctly at first Tf self._actual_str_size: dict[str, float] = { "str_widths": 0.0, "space_width": 0.0, "str_height": 0.0, } # will be set to string length calculation result self.TL = 0.0 self.font_size = 12.0 # init just in case of # Text extraction variables self.text: str = "" self.output: str = "" self.rtl_dir: bool = False # right-to-left self.cmap: tuple[Union[str, dict[int, str]], dict[str, str], str, Optional[DictionaryObject]] = ( "charmap", {}, "NotInitialized", None, ) # (encoding, CMAP, font resource name, font) self.orientations: tuple[int, ...] = (0, 90, 180, 270) self.visitor_text: Optional[Callable[[Any, Any, Any, Any, Any], None]] = None self.cmaps: dict[str, tuple[str, float, Union[str, dict[int, str]], dict[str, str], DictionaryObject]] = {} self.operation_handlers = { b"BT": self._handle_bt, b"ET": self._handle_et, b"q": self._handle_save_graphics_state, b"Q": self._handle_restore_graphics_state, b"cm": self._handle_cm, b"Tz": self._handle_tz, b"Tw": self._handle_tw, b"TL": self._handle_tl, b"Tf": self._handle_tf, b"Td": self._handle_td, b"Tm": self._handle_tm, b"T*": self._handle_t_star, b"Tj": self._handle_tj_operation, } def initialize_extraction( self, orientations: tuple[int, ...] = (0, 90, 180, 270), visitor_text: Optional[Callable[[Any, Any, Any, Any, Any], None]] = None, cmaps: Optional[ dict[str, tuple[str, float, Union[str, dict[int, str]], dict[str, str], DictionaryObject]] ] = None, ) -> None: """Initialize the extractor with extraction parameters.""" self.orientations = orientations self.visitor_text = visitor_text self.cmaps = cmaps or {} # Reset state self.text = "" self.output = "" self.rtl_dir = False def compute_str_widths(self, str_widths: float) -> float: return str_widths / 1000 def process_operation(self, operator: bytes, operands: list[Any]) -> None: if operator in self.operation_handlers: handler = self.operation_handlers[operator] str_widths = handler(operands) # Post-process operations that affect text positioning if operator in {b"Td", b"Tm", b"T*", b"Tj"}: self._post_process_text_operation(str_widths or 0.0) def _post_process_text_operation(self, str_widths: float) -> None: """Handle common post-processing for text positioning operations.""" try: self.text, self.output, self.cm_prev, self.tm_prev = crlf_space_check( self.text, (self.cm_prev, self.tm_prev), (self.cm_matrix, self.tm_matrix), (self.memo_cm, self.memo_tm), self.cmap, self.orientations, self.output, self.font_size, self.visitor_text, str_widths, self.compute_str_widths(self._actual_str_size["space_width"]), self._actual_str_size["str_height"], ) if self.text == "": self.memo_cm = self.cm_matrix.copy() self.memo_tm = self.tm_matrix.copy() except OrientationNotFoundError: pass def _get_actual_font_widths( self, cmap: tuple[ Union[str, dict[int, str]], dict[str, str], str, Optional[DictionaryObject] ], text_operands: str, font_size: float, space_width: float, ) -> tuple[float, float, float]: font_widths: float = 0 font_name: str = cmap[2] if font_name not in self._font_width_maps: if cmap[3] is None: font_width_map: dict[Any, float] = {} space_char = " " actual_space_width: float = space_width font_width_map["default"] = actual_space_width * 2 else: space_char = get_actual_str_key(" ", cmap[0], cmap[1]) font_width_map = build_font_width_map(cmap[3], space_width * 2) actual_space_width = compute_font_width(font_width_map, space_char) if actual_space_width == 0: actual_space_width = space_width self._font_width_maps[font_name] = (font_width_map, space_char, actual_space_width) font_width_map = self._font_width_maps[font_name][0] space_char = self._font_width_maps[font_name][1] actual_space_width = self._font_width_maps[font_name][2] if text_operands: for char in text_operands: if char == space_char: font_widths += actual_space_width continue font_widths += compute_font_width(font_width_map, char) return (font_widths * font_size, space_width * font_size, font_size) def _handle_tj( self, text: str, operands: list[Union[str, TextStringObject]], cm_matrix: list[float], tm_matrix: list[float], cmap: tuple[ Union[str, dict[int, str]], dict[str, str], str, Optional[DictionaryObject] ], orientations: tuple[int, ...], font_size: float, rtl_dir: bool, visitor_text: Optional[Callable[[Any, Any, Any, Any, Any], None]], space_width: float, actual_str_size: dict[str, float], ) -> tuple[str, bool, dict[str, float]]: text_operands, is_str_operands = get_text_operands( operands, cm_matrix, tm_matrix, cmap, orientations) if is_str_operands: text += text_operands else: text, rtl_dir = get_display_str( text, cm_matrix, tm_matrix, # text matrix cmap, text_operands, font_size, rtl_dir, visitor_text, ) font_widths, actual_str_size["space_width"], actual_str_size["str_height"] = ( self._get_actual_font_widths(cmap, text_operands, font_size, space_width)) actual_str_size["str_widths"] += font_widths return text, rtl_dir, actual_str_size def _flush_text(self) -> None: """Flush accumulated text to output and call visitor if present.""" self.output += self.text if self.visitor_text is not None: self.visitor_text(self.text, self.memo_cm, self.memo_tm, self.cmap[3], self.font_size) self.text = "" self.memo_cm = self.cm_matrix.copy() self.memo_tm = self.tm_matrix.copy() # Operation handlers def _handle_bt(self, operands: list[Any]) -> None: """Handle BT (Begin Text) operation - Table 5.4 page 405.""" self.tm_matrix = [1.0, 0.0, 0.0, 1.0, 0.0, 0.0] self._flush_text() def _handle_et(self, operands: list[Any]) -> None: """Handle ET (End Text) operation - Table 5.4 page 405.""" self._flush_text() def _handle_save_graphics_state(self, operands: list[Any]) -> None: """Handle q (Save graphics state) operation - Table 4.7 page 219.""" self.cm_stack.append( ( self.cm_matrix, self.cmap, self.font_size, self.char_scale, self.space_scale, self._space_width, self.TL, ) ) def _handle_restore_graphics_state(self, operands: list[Any]) -> None: """Handle Q (Restore graphics state) operation - Table 4.7 page 219.""" try: ( self.cm_matrix, self.cmap, self.font_size, self.char_scale, self.space_scale, self._space_width, self.TL, ) = self.cm_stack.pop() except Exception: self.cm_matrix = [1.0, 0.0, 0.0, 1.0, 0.0, 0.0] def _handle_cm(self, operands: list[Any]) -> None: """Handle cm (Modify current matrix) operation - Table 4.7 page 219.""" self.output += self.text if self.visitor_text is not None: self.visitor_text(self.text, self.memo_cm, self.memo_tm, self.cmap[3], self.font_size) self.text = "" try: self.cm_matrix = mult([float(operand) for operand in operands[:6]], self.cm_matrix) except Exception: self.cm_matrix = [1.0, 0.0, 0.0, 1.0, 0.0, 0.0] self.memo_cm = self.cm_matrix.copy() self.memo_tm = self.tm_matrix.copy() def _handle_tz(self, operands: list[Any]) -> None: """Handle Tz (Set horizontal text scaling) operation - Table 5.2 page 398.""" self.char_scale = float(operands[0]) / 100 if operands else 1.0 def _handle_tw(self, operands: list[Any]) -> None: """Handle Tw (Set word spacing) operation - Table 5.2 page 398.""" self.space_scale = 1.0 + float(operands[0] if operands else 0.0) def _handle_tl(self, operands: list[Any]) -> None: """Handle TL (Set Text Leading) operation - Table 5.2 page 398.""" scale_x = math.sqrt(self.tm_matrix[0] ** 2 + self.tm_matrix[2] ** 2) self.TL = float(operands[0] if operands else 0.0) * self.font_size * scale_x def _handle_tf(self, operands: list[Any]) -> None: """Handle Tf (Set font size) operation - Table 5.2 page 398.""" if self.text != "": self.output += self.text # .translate(cmap) if self.visitor_text is not None: self.visitor_text(self.text, self.memo_cm, self.memo_tm, self.cmap[3], self.font_size) self.text = "" self.memo_cm = self.cm_matrix.copy() self.memo_tm = self.tm_matrix.copy() try: # Import here to avoid circular imports from .._cmap import unknown_char_map # noqa: PLC0415 # char_map_tuple: font_type, # float(sp_width / 2), # encoding, # map_dict, # font_dict (describes the font) char_map_tuple = self.cmaps[operands[0]] # current cmap: encoding, # map_dict, # font resource name (internal name, not the real font name), # font_dict self.cmap = ( char_map_tuple[2], char_map_tuple[3], operands[0], char_map_tuple[4], ) self._space_width = char_map_tuple[1] except KeyError: # font not found self.cmap = ( unknown_char_map[2], unknown_char_map[3], f"???{operands[0]}", None, ) self._space_width = unknown_char_map[1] try: self.font_size = float(operands[1]) except Exception: pass # keep previous size def _handle_td(self, operands: list[Any]) -> float: """Handle Td (Move text position) operation - Table 5.5 page 406.""" # A special case is a translating only tm: # tm = [1, 0, 0, 1, e, f] # i.e. tm[4] += tx, tm[5] += ty. tx, ty = float(operands[0]), float(operands[1]) self.tm_matrix[4] += tx * self.tm_matrix[0] + ty * self.tm_matrix[2] self.tm_matrix[5] += tx * self.tm_matrix[1] + ty * self.tm_matrix[3] str_widths = self.compute_str_widths(self._actual_str_size["str_widths"]) self._actual_str_size["str_widths"] = 0.0 return str_widths def _handle_tm(self, operands: list[Any]) -> float: """Handle Tm (Set text matrix) operation - Table 5.5 page 406.""" self.tm_matrix = [float(operand) for operand in operands[:6]] str_widths = self.compute_str_widths(self._actual_str_size["str_widths"]) self._actual_str_size["str_widths"] = 0.0 return str_widths def _handle_t_star(self, operands: list[Any]) -> float: """Handle T* (Move to next line) operation - Table 5.5 page 406.""" self.tm_matrix[4] -= self.TL * self.tm_matrix[2] self.tm_matrix[5] -= self.TL * self.tm_matrix[3] str_widths = self.compute_str_widths(self._actual_str_size["str_widths"]) self._actual_str_size["str_widths"] = 0.0 return str_widths def _handle_tj_operation(self, operands: list[Any]) -> float: """Handle Tj (Show text) operation - Table 5.5 page 406.""" self.text, self.rtl_dir, self._actual_str_size = self._handle_tj( self.text, operands, self.cm_matrix, self.tm_matrix, self.cmap, self.orientations, self.font_size, self.rtl_dir, self.visitor_text, self._space_width, self._actual_str_size, ) return 0.0 # str_widths will be handled in post-processing pypdf-6.1.2/pypdf/_utils.py000066400000000000000000000473421507516550200156550ustar00rootroot00000000000000# Copyright (c) 2006, Mathieu Fenniak # All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. """Utility functions for PDF library.""" __author__ = "Mathieu Fenniak" __author_email__ = "biziqe@mathieu.fenniak.net" import functools import logging import re import sys import warnings from dataclasses import dataclass from datetime import datetime, timezone from io import DEFAULT_BUFFER_SIZE from os import SEEK_CUR from re import Pattern from typing import ( IO, Any, Optional, Union, overload, ) if sys.version_info[:2] >= (3, 10): # Python 3.10+: https://www.python.org/dev/peps/pep-0484/ from typing import TypeAlias else: from typing_extensions import TypeAlias if sys.version_info >= (3, 11): from typing import Self else: from typing_extensions import Self from .errors import ( STREAM_TRUNCATED_PREMATURELY, DeprecationError, PdfStreamError, ) TransformationMatrixType: TypeAlias = tuple[ tuple[float, float, float], tuple[float, float, float], tuple[float, float, float] ] CompressedTransformationMatrix: TypeAlias = tuple[ float, float, float, float, float, float ] StreamType = IO[Any] StrByteType = Union[str, StreamType] def parse_iso8824_date(text: Optional[str]) -> Optional[datetime]: orgtext = text if not text: return None if text[0].isdigit(): text = "D:" + text if text.endswith(("Z", "z")): text += "0000" text = text.replace("z", "+").replace("Z", "+").replace("'", "") i = max(text.find("+"), text.find("-")) if i > 0 and i != len(text) - 5: text += "00" for f in ( "D:%Y", "D:%Y%m", "D:%Y%m%d", "D:%Y%m%d%H", "D:%Y%m%d%H%M", "D:%Y%m%d%H%M%S", "D:%Y%m%d%H%M%S%z", ): try: d = datetime.strptime(text, f) # noqa: DTZ007 except ValueError: continue else: if text.endswith("+0000"): d = d.replace(tzinfo=timezone.utc) return d raise ValueError(f"Can not convert date: {orgtext}") def format_iso8824_date(dt: datetime) -> str: """ Convert a datetime object to PDF date string format. Converts datetime to the PDF date format D:YYYYMMDDHHmmSSOHH'mm as specified in the PDF Reference. Args: dt: A datetime object to convert. Returns: A date string in PDF format. """ date_str = dt.strftime("D:%Y%m%d%H%M%S") if dt.tzinfo is not None: offset = dt.utcoffset() assert offset is not None total_seconds = int(offset.total_seconds()) hours, remainder = divmod(abs(total_seconds), 3600) minutes = remainder // 60 sign = "+" if total_seconds >= 0 else "-" date_str += f"{sign}{hours:02d}'{minutes:02d}'" return date_str def _get_max_pdf_version_header(header1: str, header2: str) -> str: versions = ( "%PDF-1.3", "%PDF-1.4", "%PDF-1.5", "%PDF-1.6", "%PDF-1.7", "%PDF-2.0", ) pdf_header_indices = [] if header1 in versions: pdf_header_indices.append(versions.index(header1)) if header2 in versions: pdf_header_indices.append(versions.index(header2)) if len(pdf_header_indices) == 0: raise ValueError(f"Neither {header1!r} nor {header2!r} are proper headers") return versions[max(pdf_header_indices)] WHITESPACES = (b"\x00", b"\t", b"\n", b"\f", b"\r", b" ") WHITESPACES_AS_BYTES = b"".join(WHITESPACES) WHITESPACES_AS_REGEXP = b"[" + WHITESPACES_AS_BYTES + b"]" def read_until_whitespace(stream: StreamType, maxchars: Optional[int] = None) -> bytes: """ Read non-whitespace characters and return them. Stops upon encountering whitespace or when maxchars is reached. Args: stream: The data stream from which was read. maxchars: The maximum number of bytes returned; by default unlimited. Returns: The data which was read. """ txt = b"" while True: tok = stream.read(1) if tok.isspace() or not tok: break txt += tok if len(txt) == maxchars: break return txt def read_non_whitespace(stream: StreamType) -> bytes: """ Find and read the next non-whitespace character (ignores whitespace). Args: stream: The data stream from which was read. Returns: The data which was read. """ tok = stream.read(1) while tok in WHITESPACES: tok = stream.read(1) return tok def skip_over_whitespace(stream: StreamType) -> bool: """ Similar to read_non_whitespace, but return a boolean if at least one whitespace character was read. Args: stream: The data stream from which was read. Returns: True if one or more whitespace was skipped, otherwise return False. """ tok = stream.read(1) cnt = 0 while tok in WHITESPACES: cnt += 1 tok = stream.read(1) return cnt > 0 def check_if_whitespace_only(value: bytes) -> bool: """ Check if the given value consists of whitespace characters only. Args: value: The bytes to check. Returns: True if the value only has whitespace characters, otherwise return False. """ return all(b in WHITESPACES_AS_BYTES for b in value) def skip_over_comment(stream: StreamType) -> None: tok = stream.read(1) stream.seek(-1, 1) if tok == b"%": while tok not in (b"\n", b"\r"): tok = stream.read(1) if tok == b"": raise PdfStreamError("File ended unexpectedly.") def read_until_regex(stream: StreamType, regex: Pattern[bytes]) -> bytes: """ Read until the regular expression pattern matched (ignore the match). Treats EOF on the underlying stream as the end of the token to be matched. Args: regex: re.Pattern Returns: The read bytes. """ name = b"" while True: tok = stream.read(16) if not tok: return name m = regex.search(name + tok) if m is not None: stream.seek(m.start() - (len(name) + len(tok)), 1) name = (name + tok)[: m.start()] break name += tok return name def read_block_backwards(stream: StreamType, to_read: int) -> bytes: """ Given a stream at position X, read a block of size to_read ending at position X. This changes the stream's position to the beginning of where the block was read. Args: stream: to_read: Returns: The data which was read. """ if stream.tell() < to_read: raise PdfStreamError("Could not read malformed PDF file") # Seek to the start of the block we want to read. stream.seek(-to_read, SEEK_CUR) read = stream.read(to_read) # Seek to the start of the block we read after reading it. stream.seek(-to_read, SEEK_CUR) return read def read_previous_line(stream: StreamType) -> bytes: """ Given a byte stream with current position X, return the previous line. All characters between the first CR/LF byte found before X (or, the start of the file, if no such byte is found) and position X After this call, the stream will be positioned one byte after the first non-CRLF character found beyond the first CR/LF byte before X, or, if no such byte is found, at the beginning of the stream. Args: stream: StreamType: Returns: The data which was read. """ line_content = [] found_crlf = False if stream.tell() == 0: raise PdfStreamError(STREAM_TRUNCATED_PREMATURELY) while True: to_read = min(DEFAULT_BUFFER_SIZE, stream.tell()) if to_read == 0: break # Read the block. After this, our stream will be one # beyond the initial position. block = read_block_backwards(stream, to_read) idx = len(block) - 1 if not found_crlf: # We haven't found our first CR/LF yet. # Read off characters until we hit one. while idx >= 0 and block[idx] not in b"\r\n": idx -= 1 if idx >= 0: found_crlf = True if found_crlf: # We found our first CR/LF already (on this block or # a previous one). # Our combined line is the remainder of the block # plus any previously read blocks. line_content.append(block[idx + 1 :]) # Continue to read off any more CRLF characters. while idx >= 0 and block[idx] in b"\r\n": idx -= 1 else: # Didn't find CR/LF yet - add this block to our # previously read blocks and continue. line_content.append(block) if idx >= 0: # We found the next non-CRLF character. # Set the stream position correctly, then break stream.seek(idx + 1, SEEK_CUR) break # Join all the blocks in the line (which are in reverse order) return b"".join(line_content[::-1]) def matrix_multiply( a: TransformationMatrixType, b: TransformationMatrixType ) -> TransformationMatrixType: return tuple( # type: ignore[return-value] tuple(sum(float(i) * float(j) for i, j in zip(row, col)) for col in zip(*b)) for row in a ) def mark_location(stream: StreamType) -> None: """Create text file showing current location in context.""" # Mainly for debugging radius = 5000 stream.seek(-radius, 1) with open("pypdf_pdfLocation.txt", "wb") as output_fh: output_fh.write(stream.read(radius)) output_fh.write(b"HERE") output_fh.write(stream.read(radius)) stream.seek(-radius, 1) @overload def ord_(b: str) -> int: ... @overload def ord_(b: bytes) -> bytes: ... @overload def ord_(b: int) -> int: ... def ord_(b: Union[int, str, bytes]) -> Union[int, bytes]: if isinstance(b, str): return ord(b) return b def deprecate(msg: str, stacklevel: int = 3) -> None: warnings.warn(msg, DeprecationWarning, stacklevel=stacklevel) def deprecation(msg: str) -> None: raise DeprecationError(msg) def deprecate_with_replacement(old_name: str, new_name: str, removed_in: str) -> None: """Issue a warning that a feature will be removed, but has a replacement.""" deprecate( f"{old_name} is deprecated and will be removed in pypdf {removed_in}. Use {new_name} instead.", 4, ) def deprecation_with_replacement(old_name: str, new_name: str, removed_in: str) -> None: """Raise an exception that a feature was already removed, but has a replacement.""" deprecation( f"{old_name} is deprecated and was removed in pypdf {removed_in}. Use {new_name} instead." ) def deprecate_no_replacement(name: str, removed_in: str) -> None: """Issue a warning that a feature will be removed without replacement.""" deprecate(f"{name} is deprecated and will be removed in pypdf {removed_in}.", 4) def deprecation_no_replacement(name: str, removed_in: str) -> None: """Raise an exception that a feature was already removed without replacement.""" deprecation(f"{name} is deprecated and was removed in pypdf {removed_in}.") def logger_error(msg: str, src: str) -> None: """ Use this instead of logger.error directly. That allows people to overwrite it more easily. See the docs on when to use which: https://pypdf.readthedocs.io/en/latest/user/suppress-warnings.html """ logging.getLogger(src).error(msg) def logger_warning(msg: str, src: str) -> None: """ Use this instead of logger.warning directly. That allows people to overwrite it more easily. ## Exception, warnings.warn, logger_warning - Exceptions should be used if the user should write code that deals with an error case, e.g. the PDF being completely broken. - warnings.warn should be used if the user needs to fix their code, e.g. DeprecationWarnings - logger_warning should be used if the user needs to know that an issue was handled by pypdf, e.g. a non-compliant PDF being read in a way that pypdf could apply a robustness fix to still read it. This applies mainly to strict=False mode. """ logging.getLogger(src).warning(msg) def rename_kwargs( func_name: str, kwargs: dict[str, Any], aliases: dict[str, str], fail: bool = False ) -> None: """ Helper function to deprecate arguments. Args: func_name: Name of the function to be deprecated kwargs: aliases: fail: """ for old_term, new_term in aliases.items(): if old_term in kwargs: if fail: raise DeprecationError( f"{old_term} is deprecated as an argument. Use {new_term} instead" ) if new_term in kwargs: raise TypeError( f"{func_name} received both {old_term} and {new_term} as " f"an argument. {old_term} is deprecated. " f"Use {new_term} instead." ) kwargs[new_term] = kwargs.pop(old_term) warnings.warn( message=( f"{old_term} is deprecated as an argument. Use {new_term} instead" ), category=DeprecationWarning, stacklevel=3, ) def _human_readable_bytes(bytes: int) -> str: if bytes < 10**3: return f"{bytes} Byte" if bytes < 10**6: return f"{bytes / 10**3:.1f} kB" if bytes < 10**9: return f"{bytes / 10**6:.1f} MB" return f"{bytes / 10**9:.1f} GB" # The following class has been copied from Django: # https://github.com/django/django/blob/adae619426b6f50046b3daaa744db52989c9d6db/django/utils/functional.py#L51-L65 # It received some modifications to comply with our own coding standards. # # Original license: # # --------------------------------------------------------------------------------- # Copyright (c) Django Software Foundation and individual contributors. # All rights reserved. # # Redistribution and use in source and binary forms, with or without modification, # are permitted provided that the following conditions are met: # # 1. Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # # 2. Redistributions in binary form must reproduce the above copyright # notice, this list of conditions and the following disclaimer in the # documentation and/or other materials provided with the distribution. # # 3. Neither the name of Django nor the names of its contributors may be used # to endorse or promote products derived from this software without # specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND # ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED # WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE # DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE LIABLE FOR # ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES # (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; # LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON # ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT # (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS # SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. # --------------------------------------------------------------------------------- class classproperty: # noqa: N801 """ Decorator that converts a method with a single cls argument into a property that can be accessed directly from the class. """ def __init__(self, method=None) -> None: # type: ignore # noqa: ANN001 self.fget = method def __get__(self, instance, cls=None) -> Any: # type: ignore # noqa: ANN001 return self.fget(cls) def getter(self, method) -> Self: # type: ignore # noqa: ANN001 self.fget = method return self @dataclass class File: from .generic import IndirectObject # noqa: PLC0415 name: str = "" """ Filename as identified within the PDF file. """ data: bytes = b"" """ Data as bytes. """ indirect_reference: Optional[IndirectObject] = None """ Reference to the object storing the stream. """ def __str__(self) -> str: return f"{self.__class__.__name__}(name={self.name}, data: {_human_readable_bytes(len(self.data))})" def __repr__(self) -> str: return self.__str__()[:-1] + f", hash: {hash(self.data)})" @functools.total_ordering class Version: COMPONENT_PATTERN = re.compile(r"^(\d+)(.*)$") def __init__(self, version_str: str) -> None: self.version_str = version_str self.components = self._parse_version(version_str) def _parse_version(self, version_str: str) -> list[tuple[int, str]]: components = version_str.split(".") parsed_components = [] for component in components: match = Version.COMPONENT_PATTERN.match(component) if not match: parsed_components.append((0, component)) continue integer_prefix = match.group(1) suffix = match.group(2) if integer_prefix is None: integer_prefix = 0 parsed_components.append((int(integer_prefix), suffix)) return parsed_components def __eq__(self, other: object) -> bool: if not isinstance(other, Version): return False return self.components == other.components def __hash__(self) -> int: # Convert to tuple as lists cannot be hashed. return hash((self.__class__, tuple(self.components))) def __lt__(self, other: Any) -> bool: if not isinstance(other, Version): raise ValueError(f"Version cannot be compared against {type(other)}") for self_component, other_component in zip(self.components, other.components): self_value, self_suffix = self_component other_value, other_suffix = other_component if self_value < other_value: return True if self_value > other_value: return False if self_suffix < other_suffix: return True if self_suffix > other_suffix: return False return len(self.components) < len(other.components) pypdf-6.1.2/pypdf/_version.py000066400000000000000000000000261507516550200161660ustar00rootroot00000000000000__version__ = "6.1.2" pypdf-6.1.2/pypdf/_writer.py000066400000000000000000004101331507516550200160210ustar00rootroot00000000000000# Copyright (c) 2006, Mathieu Fenniak # Copyright (c) 2007, Ashish Kulkarni # # All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. import decimal import enum import hashlib import re import struct import uuid from collections.abc import Iterable, Mapping from io import BytesIO, FileIO, IOBase from itertools import compress from pathlib import Path from re import Pattern from types import TracebackType from typing import ( IO, Any, Callable, Optional, Union, cast, ) from ._cmap import _default_fonts_space_width, build_char_map_from_dict from ._doc_common import DocumentInformation, PdfDocCommon from ._encryption import EncryptAlgorithm, Encryption from ._page import PageObject, Transformation from ._page_labels import nums_clear_range, nums_insert, nums_next from ._reader import PdfReader from ._utils import ( StrByteType, StreamType, _get_max_pdf_version_header, deprecation_no_replacement, logger_warning, ) from .constants import AnnotationDictionaryAttributes as AA from .constants import CatalogAttributes as CA from .constants import ( CatalogDictionary, GoToActionArguments, ImageType, InteractiveFormDictEntries, OutlineFontFlag, PageLabelStyle, PagesAttributes, TypFitArguments, UserAccessPermissions, ) from .constants import Core as CO from .constants import FieldDictionaryAttributes as FA from .constants import PageAttributes as PG from .constants import TrailerKeys as TK from .errors import PdfReadError, PyPdfError from .generic import ( PAGE_FIT, ArrayObject, BooleanObject, ByteStringObject, ContentStream, DecodedStreamObject, Destination, DictionaryObject, EmbeddedFile, Fit, FloatObject, IndirectObject, NameObject, NullObject, NumberObject, PdfObject, RectangleObject, ReferenceLink, StreamObject, TextStringObject, TreeObject, ViewerPreferences, create_string_object, extract_links, hex_to_rgb, is_null_or_none, ) from .pagerange import PageRange, PageRangeSpec from .types import ( AnnotationSubtype, BorderArrayType, LayoutType, OutlineItemType, OutlineType, PagemodeType, ) from .xmp import XmpInformation ALL_DOCUMENT_PERMISSIONS = UserAccessPermissions.all() DEFAULT_FONT_HEIGHT_IN_MULTILINE = 12 class ObjectDeletionFlag(enum.IntFlag): NONE = 0 TEXT = enum.auto() LINKS = enum.auto() ATTACHMENTS = enum.auto() OBJECTS_3D = enum.auto() ALL_ANNOTATIONS = enum.auto() XOBJECT_IMAGES = enum.auto() INLINE_IMAGES = enum.auto() DRAWING_IMAGES = enum.auto() IMAGES = XOBJECT_IMAGES | INLINE_IMAGES | DRAWING_IMAGES def _rolling_checksum(stream: BytesIO, blocksize: int = 65536) -> str: hash = hashlib.md5(usedforsecurity=False) for block in iter(lambda: stream.read(blocksize), b""): hash.update(block) return hash.hexdigest() class PdfWriter(PdfDocCommon): """ Write a PDF file out, given pages produced by another class or through cloning a PDF file during initialization. Typically data is added from a :class:`PdfReader`. Args: clone_from: identical to fileobj (for compatibility) incremental: If true, loads the document and set the PdfWriter in incremental mode. When writing incrementally, the original document is written first and new/modified content is appended. To be used for signed document/forms to keep signature valid. full: If true, loads all the objects (always full if incremental = True). This parameter may allow loading large PDFs. """ def __init__( self, fileobj: Union[None, PdfReader, StrByteType, Path] = "", clone_from: Union[None, PdfReader, StrByteType, Path] = None, incremental: bool = False, full: bool = False, ) -> None: self.incremental = incremental or full """ Returns if the PdfWriter object has been started in incremental mode. """ self._objects: list[Optional[PdfObject]] = [] """ The indirect objects in the PDF. For the incremental case, it will be filled with None in clone_reader_document_root. """ self._original_hash: list[int] = [] """ List of hashes after import; used to identify changes. """ self._idnum_hash: dict[bytes, tuple[IndirectObject, list[IndirectObject]]] = {} """ Maps hash values of indirect objects to the list of IndirectObjects. This is used for compression. """ self._id_translated: dict[int, dict[int, int]] = {} """List of already translated IDs. dict[id(pdf)][(idnum, generation)] """ self._info_obj: Optional[PdfObject] """The PDF files's document information dictionary, the Info entry in the PDF file's trailer dictionary.""" self._ID: Union[ArrayObject, None] = None """The PDF file identifier, defined by the ID in the PDF file's trailer dictionary.""" self._unresolved_links: list[tuple[ReferenceLink, ReferenceLink]] = [] "Tracks links in pages added to the writer for resolving later." self._merged_in_pages: dict[Optional[IndirectObject], Optional[IndirectObject]] = {} "Tracks pages added to the writer and what page they turned into." if self.incremental: if isinstance(fileobj, (str, Path)): with open(fileobj, "rb") as f: fileobj = BytesIO(f.read(-1)) if isinstance(fileobj, BytesIO): fileobj = PdfReader(fileobj) if not isinstance(fileobj, PdfReader): raise PyPdfError("Invalid type for incremental mode") self._reader = fileobj # prev content is in _reader.stream self._header = fileobj.pdf_header.encode() self._readonly = True # TODO: to be analysed else: self._header = b"%PDF-1.3" self._info_obj = self._add_object( DictionaryObject( {NameObject("/Producer"): create_string_object("pypdf")} ) ) def _get_clone_from( fileobj: Union[None, PdfReader, str, Path, IO[Any], BytesIO], clone_from: Union[None, PdfReader, str, Path, IO[Any], BytesIO], ) -> Union[None, PdfReader, str, Path, IO[Any], BytesIO]: if isinstance(fileobj, (str, Path, IO, BytesIO)) and ( fileobj == "" or clone_from is not None ): return clone_from cloning = True if isinstance(fileobj, (str, Path)) and ( not Path(str(fileobj)).exists() or Path(str(fileobj)).stat().st_size == 0 ): cloning = False if isinstance(fileobj, (IOBase, BytesIO)): t = fileobj.tell() if fileobj.seek(0, 2) == 0: cloning = False fileobj.seek(t, 0) if cloning: clone_from = fileobj return clone_from clone_from = _get_clone_from(fileobj, clone_from) # To prevent overwriting self.temp_fileobj = fileobj self.fileobj = "" self._with_as_usage = False self._cloned = False # The root of our page tree node pages = DictionaryObject( { NameObject(PagesAttributes.TYPE): NameObject("/Pages"), NameObject(PagesAttributes.COUNT): NumberObject(0), NameObject(PagesAttributes.KIDS): ArrayObject(), } ) self.flattened_pages = [] self._encryption: Optional[Encryption] = None self._encrypt_entry: Optional[DictionaryObject] = None if clone_from is not None: if not isinstance(clone_from, PdfReader): clone_from = PdfReader(clone_from) self.clone_document_from_reader(clone_from) self._cloned = True else: self._pages = self._add_object(pages) self._root_object = DictionaryObject( { NameObject(PagesAttributes.TYPE): NameObject(CO.CATALOG), NameObject(CO.PAGES): self._pages, } ) self._add_object(self._root_object) if full and not incremental: self.incremental = False if isinstance(self._ID, list): if isinstance(self._ID[0], TextStringObject): self._ID[0] = ByteStringObject(self._ID[0].get_original_bytes()) if isinstance(self._ID[1], TextStringObject): self._ID[1] = ByteStringObject(self._ID[1].get_original_bytes()) # for commonality @property def is_encrypted(self) -> bool: """ Read-only boolean property showing whether this PDF file is encrypted. Note that this property, if true, will remain true even after the :meth:`decrypt()` method is called. """ return False @property def root_object(self) -> DictionaryObject: """ Provide direct access to PDF Structure. Note: Recommended only for read access. """ return self._root_object @property def _info(self) -> Optional[DictionaryObject]: """ Provide access to "/Info". Standardized with PdfReader. Returns: /Info Dictionary; None if the entry does not exist """ return ( None if self._info_obj is None else cast(DictionaryObject, self._info_obj.get_object()) ) @_info.setter def _info(self, value: Optional[Union[IndirectObject, DictionaryObject]]) -> None: if value is None: try: self._objects[self._info_obj.indirect_reference.idnum - 1] = None # type: ignore except (KeyError, AttributeError): pass self._info_obj = None else: if self._info_obj is None: self._info_obj = self._add_object(DictionaryObject()) obj = cast(DictionaryObject, self._info_obj.get_object()) obj.clear() obj.update(cast(DictionaryObject, value.get_object())) @property def xmp_metadata(self) -> Optional[XmpInformation]: """XMP (Extensible Metadata Platform) data.""" return cast(XmpInformation, self.root_object.xmp_metadata) @xmp_metadata.setter def xmp_metadata(self, value: Union[XmpInformation, bytes, None]) -> None: """XMP (Extensible Metadata Platform) data.""" if value is None: if "/Metadata" in self.root_object: del self.root_object["/Metadata"] return metadata = self.root_object.get("/Metadata", None) if not isinstance(metadata, IndirectObject): if metadata is not None: del self.root_object["/Metadata"] metadata_stream = StreamObject() stream_reference = self._add_object(metadata_stream) self.root_object[NameObject("/Metadata")] = stream_reference else: metadata_stream = cast(StreamObject, metadata.get_object()) if isinstance(value, XmpInformation): bytes_data = value.stream.get_data() else: bytes_data = value metadata_stream.set_data(bytes_data) @property def with_as_usage(self) -> bool: deprecation_no_replacement("with_as_usage", "5.0") return self._with_as_usage @with_as_usage.setter def with_as_usage(self, value: bool) -> None: deprecation_no_replacement("with_as_usage", "5.0") self._with_as_usage = value def __enter__(self) -> "PdfWriter": """Store how writer is initialized by 'with'.""" c: bool = self._cloned t = self.temp_fileobj self.__init__() # type: ignore self._cloned = c self._with_as_usage = True self.fileobj = t # type: ignore return self def __exit__( self, exc_type: Optional[type[BaseException]], exc: Optional[BaseException], traceback: Optional[TracebackType], ) -> None: """Write data to the fileobj.""" if self.fileobj and not self._cloned: self.write(self.fileobj) @property def pdf_header(self) -> str: """ Read/Write property of the PDF header that is written. This should be something like ``'%PDF-1.5'``. It is recommended to set the lowest version that supports all features which are used within the PDF file. Note: `pdf_header` returns a string but accepts bytes or str for writing """ return self._header.decode() @pdf_header.setter def pdf_header(self, new_header: Union[str, bytes]) -> None: if isinstance(new_header, str): new_header = new_header.encode() self._header = new_header def _add_object(self, obj: PdfObject) -> IndirectObject: if ( getattr(obj, "indirect_reference", None) is not None and obj.indirect_reference.pdf == self # type: ignore ): return obj.indirect_reference # type: ignore # check for /Contents in Pages (/Contents in annotations are strings) if isinstance(obj, DictionaryObject) and isinstance( obj.get(PG.CONTENTS, None), (ArrayObject, DictionaryObject) ): obj[NameObject(PG.CONTENTS)] = self._add_object(obj[PG.CONTENTS]) self._objects.append(obj) obj.indirect_reference = IndirectObject(len(self._objects), 0, self) return obj.indirect_reference def get_object( self, indirect_reference: Union[int, IndirectObject], ) -> PdfObject: if isinstance(indirect_reference, int): obj = self._objects[indirect_reference - 1] elif indirect_reference.pdf != self: raise ValueError("PDF must be self") else: obj = self._objects[indirect_reference.idnum - 1] assert obj is not None, "mypy" return obj def _replace_object( self, indirect_reference: Union[int, IndirectObject], obj: PdfObject, ) -> PdfObject: if isinstance(indirect_reference, IndirectObject): if indirect_reference.pdf != self: raise ValueError("PDF must be self") indirect_reference = indirect_reference.idnum gen = self._objects[indirect_reference - 1].indirect_reference.generation # type: ignore if ( getattr(obj, "indirect_reference", None) is not None and obj.indirect_reference.pdf != self # type: ignore ): obj = obj.clone(self) self._objects[indirect_reference - 1] = obj obj.indirect_reference = IndirectObject(indirect_reference, gen, self) assert isinstance(obj, PdfObject), "mypy" return obj def _add_page( self, page: PageObject, index: int, excluded_keys: Iterable[str] = (), ) -> PageObject: if not isinstance(page, PageObject) or page.get(PagesAttributes.TYPE, None) != CO.PAGE: raise ValueError("Invalid page object") assert self.flattened_pages is not None, "for mypy" page_org = page excluded_keys = list(excluded_keys) excluded_keys += [PagesAttributes.PARENT, "/StructParents"] # Acrobat does not accept two indirect references pointing on the same # page; therefore in order to add multiple copies of the same # page, we need to create a new dictionary for the page, however the # objects below (including content) are not duplicated: try: # delete an already existing page del self._id_translated[id(page_org.indirect_reference.pdf)][ # type: ignore page_org.indirect_reference.idnum # type: ignore ] except Exception: pass page = cast( "PageObject", page_org.clone(self, False, excluded_keys).get_object() ) if page_org.pdf is not None: other = page_org.pdf.pdf_header self.pdf_header = _get_max_pdf_version_header(self.pdf_header, other) node, idx = self._get_page_in_node(index) page[NameObject(PagesAttributes.PARENT)] = node.indirect_reference if idx >= 0: cast(ArrayObject, node[PagesAttributes.KIDS]).insert(idx, page.indirect_reference) self.flattened_pages.insert(index, page) else: cast(ArrayObject, node[PagesAttributes.KIDS]).append(page.indirect_reference) self.flattened_pages.append(page) recurse = 0 while not is_null_or_none(node): node = cast(DictionaryObject, node.get_object()) node[NameObject(PagesAttributes.COUNT)] = NumberObject(cast(int, node[PagesAttributes.COUNT]) + 1) node = node.get(PagesAttributes.PARENT, None) # type: ignore[assignment] # TODO: Fix. recurse += 1 if recurse > 1000: raise PyPdfError("Too many recursive calls!") if page_org.pdf is not None: # the page may contain links to other pages, and those other # pages may or may not already be added. we store the # information we need, so that we can resolve the references # later. self._unresolved_links.extend(extract_links(page, page_org)) self._merged_in_pages[page_org.indirect_reference] = page.indirect_reference return page def set_need_appearances_writer(self, state: bool = True) -> None: """ Sets the "NeedAppearances" flag in the PDF writer. The "NeedAppearances" flag indicates whether the appearance dictionary for form fields should be automatically generated by the PDF viewer or if the embedded appearance should be used. Args: state: The actual value of the NeedAppearances flag. Returns: None """ # See §12.7.2 and §7.7.2 for more information: # https://opensource.adobe.com/dc-acrobat-sdk-docs/pdfstandards/PDF32000_2008.pdf try: # get the AcroForm tree if CatalogDictionary.ACRO_FORM not in self._root_object: self._root_object[ NameObject(CatalogDictionary.ACRO_FORM) ] = self._add_object(DictionaryObject()) need_appearances = NameObject(InteractiveFormDictEntries.NeedAppearances) cast(DictionaryObject, self._root_object[CatalogDictionary.ACRO_FORM])[ need_appearances ] = BooleanObject(state) except Exception as exc: # pragma: no cover logger_warning( f"set_need_appearances_writer({state}) catch : {exc}", __name__ ) def create_viewer_preferences(self) -> ViewerPreferences: o = ViewerPreferences() self._root_object[ NameObject(CatalogDictionary.VIEWER_PREFERENCES) ] = self._add_object(o) return o def add_page( self, page: PageObject, excluded_keys: Iterable[str] = (), ) -> PageObject: """ Add a page to this PDF file. Recommended for advanced usage including the adequate excluded_keys. The page is usually acquired from a :class:`PdfReader` instance. Args: page: The page to add to the document. Should be an instance of :class:`PageObject` excluded_keys: Returns: The added PageObject. """ assert self.flattened_pages is not None, "mypy" return self._add_page(page, len(self.flattened_pages), excluded_keys) def insert_page( self, page: PageObject, index: int = 0, excluded_keys: Iterable[str] = (), ) -> PageObject: """ Insert a page in this PDF file. The page is usually acquired from a :class:`PdfReader` instance. Args: page: The page to add to the document. index: Position at which the page will be inserted. excluded_keys: Returns: The added PageObject. """ assert self.flattened_pages is not None, "mypy" if index < 0: index = len(self.flattened_pages) + index if index < 0: raise ValueError("Invalid index value") if index >= len(self.flattened_pages): return self.add_page(page, excluded_keys) return self._add_page(page, index, excluded_keys) def _get_page_number_by_indirect( self, indirect_reference: Union[None, int, NullObject, IndirectObject] ) -> Optional[int]: """ Generate _page_id2num. Args: indirect_reference: Returns: The page number or None """ # To provide same function as in PdfReader if is_null_or_none(indirect_reference): return None assert indirect_reference is not None, "mypy" if isinstance(indirect_reference, int): indirect_reference = IndirectObject(indirect_reference, 0, self) obj = indirect_reference.get_object() if isinstance(obj, PageObject): return obj.page_number return None def add_blank_page( self, width: Optional[float] = None, height: Optional[float] = None ) -> PageObject: """ Append a blank page to this PDF file and return it. If no page size is specified, use the size of the last page. Args: width: The width of the new page expressed in default user space units. height: The height of the new page expressed in default user space units. Returns: The newly appended page. Raises: PageSizeNotDefinedError: if width and height are not defined and previous page does not exist. """ page = PageObject.create_blank_page(self, width, height) return self.add_page(page) def insert_blank_page( self, width: Optional[Union[float, decimal.Decimal]] = None, height: Optional[Union[float, decimal.Decimal]] = None, index: int = 0, ) -> PageObject: """ Insert a blank page to this PDF file and return it. If no page size is specified, use the size of the last page. Args: width: The width of the new page expressed in default user space units. height: The height of the new page expressed in default user space units. index: Position to add the page. Returns: The newly inserted page. Raises: PageSizeNotDefinedError: if width and height are not defined and previous page does not exist. """ if width is None or (height is None and index < self.get_num_pages()): oldpage = self.pages[index] width = oldpage.mediabox.width height = oldpage.mediabox.height page = PageObject.create_blank_page(self, width, height) self.insert_page(page, index) return page @property def open_destination( self, ) -> Union[None, Destination, TextStringObject, ByteStringObject]: return super().open_destination @open_destination.setter def open_destination(self, dest: Union[None, str, Destination, PageObject]) -> None: if dest is None: try: del self._root_object["/OpenAction"] except KeyError: pass elif isinstance(dest, str): self._root_object[NameObject("/OpenAction")] = TextStringObject(dest) elif isinstance(dest, Destination): self._root_object[NameObject("/OpenAction")] = dest.dest_array elif isinstance(dest, PageObject): self._root_object[NameObject("/OpenAction")] = Destination( "Opening", dest.indirect_reference if dest.indirect_reference is not None else NullObject(), PAGE_FIT, ).dest_array def add_js(self, javascript: str) -> None: """ Add JavaScript which will launch upon opening this PDF. Args: javascript: Your JavaScript. >>> output.add_js("this.print({bUI:true,bSilent:false,bShrinkToFit:true});") # Example: This will launch the print window when the PDF is opened. """ # Names / JavaScript preferred to be able to add multiple scripts if "/Names" not in self._root_object: self._root_object[NameObject(CA.NAMES)] = DictionaryObject() names = cast(DictionaryObject, self._root_object[CA.NAMES]) if "/JavaScript" not in names: names[NameObject("/JavaScript")] = DictionaryObject( {NameObject("/Names"): ArrayObject()} ) js_list = cast( ArrayObject, cast(DictionaryObject, names["/JavaScript"])["/Names"] ) # We need a name for parameterized JavaScript in the PDF file, # but it can be anything. js_list.append(create_string_object(str(uuid.uuid4()))) js = DictionaryObject( { NameObject(PagesAttributes.TYPE): NameObject("/Action"), NameObject("/S"): NameObject("/JavaScript"), NameObject("/JS"): TextStringObject(f"{javascript}"), } ) js_list.append(self._add_object(js)) def add_attachment(self, filename: str, data: Union[str, bytes]) -> "EmbeddedFile": """ Embed a file inside the PDF. Reference: https://opensource.adobe.com/dc-acrobat-sdk-docs/pdfstandards/PDF32000_2008.pdf Section 7.11.3 Args: filename: The filename to display. data: The data in the file. Returns: EmbeddedFile instance for the newly created embedded file. """ return EmbeddedFile._create_new(self, filename, data) def append_pages_from_reader( self, reader: PdfReader, after_page_append: Optional[Callable[[PageObject], None]] = None, ) -> None: """ Copy pages from reader to writer. Includes an optional callback parameter which is invoked after pages are appended to the writer. ``append`` should be preferred. Args: reader: a PdfReader object from which to copy page annotations to this writer object. The writer's annots will then be updated. after_page_append: Callback function that is invoked after each page is appended to the writer. Signature includes a reference to the appended page (delegates to append_pages_from_reader). The single parameter of the callback is a reference to the page just appended to the document. """ reader_num_pages = len(reader.pages) # Copy pages from reader to writer for reader_page_number in range(reader_num_pages): reader_page = reader.pages[reader_page_number] writer_page = self.add_page(reader_page) # Trigger callback, pass writer page as parameter if callable(after_page_append): after_page_append(writer_page) def _merge_content_stream_to_page( self, page: PageObject, new_content_data: bytes, ) -> None: """ Combines existing content stream(s) with new content (as bytes). Args: page: The page to which the new content data will be added. new_content_data: A binary-encoded new content stream, for instance the commands to draw an XObject. """ # First resolve the existing page content. This always is an IndirectObject: # PDF Explained by John Whitington # https://www.oreilly.com/library/view/pdf-explained/9781449321581/ch04.html if NameObject("/Contents") in page: existing_content_ref = page[NameObject("/Contents")] existing_content = existing_content_ref.get_object() if isinstance(existing_content, ArrayObject): # Create a new StreamObject for the new_content_data new_stream_obj = StreamObject() new_stream_obj.set_data(new_content_data) existing_content.append(self._add_object(new_stream_obj)) page[NameObject("/Contents")] = self._add_object(existing_content) if isinstance(existing_content, StreamObject): # Merge new content to existing StreamObject merged_data = existing_content.get_data() + b"\n" + new_content_data new_stream = StreamObject() new_stream.set_data(merged_data) page[NameObject("/Contents")] = self._add_object(new_stream) else: # If no existing content, then we have an empty page. # Create a new StreamObject in a new /Contents entry. new_stream = StreamObject() new_stream.set_data(new_content_data) page[NameObject("/Contents")] = self._add_object(new_stream) def _add_apstream_object( self, page: PageObject, appearance_stream_obj: StreamObject, object_name: str, x_offset: float, y_offset: float, font_res: Optional[DictionaryObject] = None ) -> None: """ Adds an appearance stream to the page content in the form of an XObject. Args: page: The page to which to add the appearance stream. appearance_stream_obj: The appearance stream. object_name: The name of the appearance stream. x_offset: The horizontal offset for the appearance stream. y_offset: The vertical offset for the appearance stream. font_res: The appearance stream's font resource (if given). """ # Prepare XObject resource dictionary on the page pg_res = cast(DictionaryObject, page[PG.RESOURCES]) if font_res is not None: font_name = font_res["/BaseFont"] # [/"Name"] often also exists, but is deprecated if "/Font" not in pg_res: pg_res[NameObject("/Font")] = DictionaryObject() pg_ft_res = cast(DictionaryObject, pg_res[NameObject("/Font")]) if font_name not in pg_ft_res: pg_ft_res[NameObject(font_name)] = font_res # Always add the resolved stream object to the writer to get a new IndirectObject. # This ensures we have a valid IndirectObject managed by *this* writer. xobject_ref = self._add_object(appearance_stream_obj) xobject_name = NameObject(f"/Fm_{object_name}")._sanitize() if "/XObject" not in pg_res: pg_res[NameObject("/XObject")] = DictionaryObject() pg_xo_res = cast(DictionaryObject, pg_res["/XObject"]) if xobject_name not in pg_xo_res: pg_xo_res[xobject_name] = xobject_ref else: logger_warning( f"XObject {xobject_name!r} already added to page resources. This might be an issue.", __name__ ) xobject_cm = Transformation().translate(x_offset, y_offset) xobject_drawing_commands = f"q\n{xobject_cm._to_cm()}\n{xobject_name} Do\nQ".encode() self._merge_content_stream_to_page(page, xobject_drawing_commands) def _update_field_annotation( self, page: PageObject, field: DictionaryObject, annotation: DictionaryObject, font_name: str = "", font_size: float = -1, flatten: bool = False, ) -> None: # Calculate rectangle dimensions _rct = cast(RectangleObject, annotation[AA.Rect]) rct = RectangleObject((0, 0, abs(_rct[2] - _rct[0]), abs(_rct[3] - _rct[1]))) # Extract font information da = annotation.get_inherited( AA.DA, cast(DictionaryObject, self.root_object[CatalogDictionary.ACRO_FORM]).get( AA.DA, None ), ) if da is None: da = TextStringObject("/Helv 0 Tf 0 g") else: da = da.get_object() font_properties = da.replace("\n", " ").replace("\r", " ").split(" ") font_properties = [x for x in font_properties if x != ""] if font_name: font_properties[font_properties.index("Tf") - 2] = font_name else: font_name = font_properties[font_properties.index("Tf") - 2] font_height = ( font_size if font_size >= 0 else float(font_properties[font_properties.index("Tf") - 1]) ) if font_height == 0: if field.get(FA.Ff, 0) & FA.FfBits.Multiline: font_height = DEFAULT_FONT_HEIGHT_IN_MULTILINE else: font_height = rct.height - 2 font_properties[font_properties.index("Tf") - 1] = str(font_height) da = " ".join(font_properties) y_offset = rct.height - 1 - font_height # Retrieve font information from local DR ... dr: Any = cast( DictionaryObject, cast( DictionaryObject, annotation.get_inherited( "/DR", cast( DictionaryObject, self.root_object[CatalogDictionary.ACRO_FORM] ).get("/DR", DictionaryObject()), ), ).get_object(), ) dr = dr.get("/Font", DictionaryObject()).get_object() # _default_fonts_space_width keys is the list of Standard fonts if font_name not in dr and font_name not in _default_fonts_space_width: # ...or AcroForm dictionary dr = cast( dict[Any, Any], cast( DictionaryObject, self.root_object[CatalogDictionary.ACRO_FORM] ).get("/DR", {}), ) dr = dr.get_object().get("/Font", DictionaryObject()).get_object() font_res = dr.get(font_name, None) if not is_null_or_none(font_res): font_res = cast(DictionaryObject, font_res.get_object()) _font_subtype, _, font_encoding, font_map = build_char_map_from_dict( 200, font_res ) try: # remove width stored in -1 key del font_map[-1] except KeyError: pass font_full_rev: dict[str, bytes] if isinstance(font_encoding, str): font_full_rev = { v: k.encode(font_encoding) for k, v in font_map.items() } else: font_full_rev = {v: bytes((k,)) for k, v in font_encoding.items()} font_encoding_rev = {v: bytes((k,)) for k, v in font_encoding.items()} for key, value in font_map.items(): font_full_rev[value] = font_encoding_rev.get(key, key) else: logger_warning(f"Font dictionary for {font_name} not found.", __name__) font_full_rev = {} # Retrieve field text and selected values field_flags = field.get(FA.Ff, 0) if field.get(FA.FT, "/Tx") == "/Ch" and field_flags & FA.FfBits.Combo == 0: txt = "\n".join(annotation.get_inherited(FA.Opt, [])) sel = field.get("/V", []) if not isinstance(sel, list): sel = [sel] else: # /Tx txt = field.get("/V", "") sel = [] # Escape parentheses (PDF 1.7 reference, table 3.2, Literal Strings) txt = txt.replace("\\", "\\\\").replace("(", r"\(").replace(")", r"\)") # Generate appearance stream ap_stream = generate_appearance_stream( txt, sel, da, font_full_rev, rct, font_height, y_offset ) # Create appearance dictionary dct = DecodedStreamObject.initialize_from_dictionary( { NameObject("/Type"): NameObject("/XObject"), NameObject("/Subtype"): NameObject("/Form"), NameObject("/BBox"): rct, "__streamdata__": ByteStringObject(ap_stream), "/Length": 0, } ) if AA.AP in annotation: for k, v in cast(DictionaryObject, annotation[AA.AP]).get("/N", {}).items(): if k not in {"/BBox", "/Length", "/Subtype", "/Type", "/Filter"}: dct[k] = v # Update Resources with font information if necessary if font_res is not None: dct[NameObject("/Resources")] = DictionaryObject( { NameObject("/Font"): DictionaryObject( { NameObject(font_name): getattr( font_res, "indirect_reference", font_res ) } ) } ) if AA.AP not in annotation: annotation[NameObject(AA.AP)] = DictionaryObject( {NameObject("/N"): self._add_object(dct)} ) elif "/N" not in cast(DictionaryObject, annotation[AA.AP]): cast(DictionaryObject, annotation[NameObject(AA.AP)])[ NameObject("/N") ] = self._add_object(dct) else: # [/AP][/N] exists n = annotation[AA.AP]["/N"].indirect_reference.idnum # type: ignore self._objects[n - 1] = dct dct.indirect_reference = IndirectObject(n, 0, self) if flatten: field_name = self._get_qualified_field_name(annotation) self._add_apstream_object(page, dct, field_name, _rct[0], _rct[1], font_res) FFBITS_NUL = FA.FfBits(0) def update_page_form_field_values( self, page: Union[PageObject, list[PageObject], None], fields: Mapping[str, Union[str, list[str], tuple[str, str, float]]], flags: FA.FfBits = FFBITS_NUL, auto_regenerate: Optional[bool] = True, flatten: bool = False, ) -> None: """ Update the form field values for a given page from a fields dictionary. Copy field texts and values from fields to page. If the field links to a parent object, add the information to the parent. Args: page: `PageObject` - references **PDF writer's page** where the annotations and field data will be updated. `List[Pageobject]` - provides list of pages to be processed. `None` - all pages. fields: a Python dictionary of: * field names (/T) as keys and text values (/V) as value * field names (/T) as keys and list of text values (/V) for multiple choice list * field names (/T) as keys and tuple of: * text values (/V) * font id (e.g. /F1, the font id must exist) * font size (0 for autosize) flags: A set of flags from :class:`~pypdf.constants.FieldDictionaryAttributes.FfBits`. auto_regenerate: Set/unset the need_appearances flag; the flag is unchanged if auto_regenerate is None. flatten: Whether or not to flatten the annotation. If True, this adds the annotation's appearance stream to the page contents. Note that this option does not remove the annotation itself. """ if CatalogDictionary.ACRO_FORM not in self._root_object: raise PyPdfError("No /AcroForm dictionary in PDF of PdfWriter Object") af = cast(DictionaryObject, self._root_object[CatalogDictionary.ACRO_FORM]) if InteractiveFormDictEntries.Fields not in af: raise PyPdfError("No /Fields dictionary in PDF of PdfWriter Object") if isinstance(auto_regenerate, bool): self.set_need_appearances_writer(auto_regenerate) # Iterate through pages, update field values if page is None: page = list(self.pages) if isinstance(page, list): for p in page: if PG.ANNOTS in p: # just to prevent warnings self.update_page_form_field_values(p, fields, flags, None, flatten=flatten) return if PG.ANNOTS not in page: logger_warning("No fields to update on this page", __name__) return for annotation in page[PG.ANNOTS]: # type: ignore annotation = cast(DictionaryObject, annotation.get_object()) if annotation.get("/Subtype", "") != "/Widget": continue if "/FT" in annotation and "/T" in annotation: parent_annotation = annotation else: parent_annotation = annotation.get( PG.PARENT, DictionaryObject() ).get_object() for field, value in fields.items(): if not ( self._get_qualified_field_name(parent_annotation) == field or parent_annotation.get("/T", None) == field ): continue if ( parent_annotation.get("/FT", None) == "/Ch" and "/I" in parent_annotation ): del parent_annotation["/I"] if flags: annotation[NameObject(FA.Ff)] = NumberObject(flags) if not (value is None and flatten): # Only change values if given by user and not flattening. if isinstance(value, list): lst = ArrayObject(TextStringObject(v) for v in value) parent_annotation[NameObject(FA.V)] = lst elif isinstance(value, tuple): annotation[NameObject(FA.V)] = TextStringObject( value[0], ) else: parent_annotation[NameObject(FA.V)] = TextStringObject(value) if parent_annotation.get(FA.FT) == "/Btn": # Checkbox button (no /FT found in Radio widgets) v = NameObject(value) ap = cast(DictionaryObject, annotation[NameObject(AA.AP)]) normal_ap = cast(DictionaryObject, ap["/N"]) if v not in normal_ap: v = NameObject("/Off") appearance_stream_obj = normal_ap.get(v) # other cases will be updated through the for loop annotation[NameObject(AA.AS)] = v annotation[NameObject(FA.V)] = v if flatten and appearance_stream_obj is not None: # We basically copy the entire appearance stream, which should be an XObject that # is already registered. No need to add font resources. rct = cast(RectangleObject, annotation[AA.Rect]) self._add_apstream_object(page, appearance_stream_obj, field, rct[0], rct[1]) elif ( parent_annotation.get(FA.FT) == "/Tx" or parent_annotation.get(FA.FT) == "/Ch" ): # textbox if isinstance(value, tuple): self._update_field_annotation( page, parent_annotation, annotation, value[1], value[2], flatten=flatten ) else: self._update_field_annotation(page, parent_annotation, annotation, flatten=flatten) elif ( annotation.get(FA.FT) == "/Sig" ): # deprecated # not implemented yet logger_warning("Signature forms not implemented yet", __name__) def reattach_fields( self, page: Optional[PageObject] = None ) -> list[DictionaryObject]: """ Parse annotations within the page looking for orphan fields and reattach then into the Fields Structure. Args: page: page to analyze. If none is provided, all pages will be analyzed. Returns: list of reattached fields. """ lst = [] if page is None: for p in self.pages: lst += self.reattach_fields(p) return lst try: af = cast(DictionaryObject, self._root_object[CatalogDictionary.ACRO_FORM]) except KeyError: af = DictionaryObject() self._root_object[NameObject(CatalogDictionary.ACRO_FORM)] = af try: fields = cast(ArrayObject, af[InteractiveFormDictEntries.Fields]) except KeyError: fields = ArrayObject() af[NameObject(InteractiveFormDictEntries.Fields)] = fields if "/Annots" not in page: return lst annotations = cast(ArrayObject, page["/Annots"]) for idx, annotation in enumerate(annotations): is_indirect = isinstance(annotation, IndirectObject) annotation = cast(DictionaryObject, annotation.get_object()) if annotation.get("/Subtype", "") == "/Widget" and "/FT" in annotation: if ( "indirect_reference" in annotation.__dict__ and annotation.indirect_reference in fields ): continue if not is_indirect: annotations[idx] = self._add_object(annotation) fields.append(annotation.indirect_reference) lst.append(annotation) return lst def clone_reader_document_root(self, reader: PdfReader) -> None: """ Copy the reader document root to the writer and all sub-elements, including pages, threads, outlines,... For partial insertion, ``append`` should be considered. Args: reader: PdfReader from which the document root should be copied. """ self._info_obj = None if self.incremental: self._objects = [None] * (cast(int, reader.trailer["/Size"]) - 1) for i in range(len(self._objects)): o = reader.get_object(i + 1) if o is not None: self._objects[i] = o.replicate(self) else: self._objects.clear() self._root_object = reader.root_object.clone(self) self._pages = self._root_object.raw_get("/Pages") if len(self._objects) > cast(int, reader.trailer["/Size"]): if self.strict: raise PdfReadError( f"Object count {len(self._objects)} exceeds defined trailer size {reader.trailer['/Size']}" ) logger_warning( f"Object count {len(self._objects)} exceeds defined trailer size {reader.trailer['/Size']}", __name__ ) # must be done here before rewriting if self.incremental: self._original_hash = [ (obj.hash_bin() if obj is not None else 0) for obj in self._objects ] try: self._flatten() except IndexError: raise PdfReadError("Got index error while flattening.") assert self.flattened_pages is not None for p in self.flattened_pages: self._replace_object(cast(IndirectObject, p.indirect_reference).idnum, p) if not self.incremental: p[NameObject("/Parent")] = self._pages if not self.incremental: cast(DictionaryObject, self._pages.get_object())[ NameObject("/Kids") ] = ArrayObject([p.indirect_reference for p in self.flattened_pages]) def clone_document_from_reader( self, reader: PdfReader, after_page_append: Optional[Callable[[PageObject], None]] = None, ) -> None: """ Create a copy (clone) of a document from a PDF file reader cloning section '/Root' and '/Info' and '/ID' of the pdf. Args: reader: PDF file reader instance from which the clone should be created. after_page_append: Callback function that is invoked after each page is appended to the writer. Signature includes a reference to the appended page (delegates to append_pages_from_reader). The single parameter of the callback is a reference to the page just appended to the document. """ self.clone_reader_document_root(reader) inf = reader._info if self.incremental: if inf is not None: self._info_obj = cast( IndirectObject, inf.clone(self).indirect_reference ) assert isinstance(self._info, DictionaryObject), "for mypy" self._original_hash[ self._info_obj.indirect_reference.idnum - 1 ] = self._info.hash_bin() elif inf is not None: self._info_obj = self._add_object( DictionaryObject(cast(DictionaryObject, inf.get_object())) ) # else: _info_obj = None done in clone_reader_document_root() try: self._ID = cast(ArrayObject, reader._ID).clone(self) except AttributeError: pass if callable(after_page_append): for page in cast( ArrayObject, cast(DictionaryObject, self._pages.get_object())["/Kids"] ): after_page_append(page.get_object()) def _compute_document_identifier(self) -> ByteStringObject: stream = BytesIO() self._write_pdf_structure(stream) stream.seek(0) return ByteStringObject(_rolling_checksum(stream).encode("utf8")) def generate_file_identifiers(self) -> None: """ Generate an identifier for the PDF that will be written. The only point of this is ensuring uniqueness. Reproducibility is not required. When a file is first written, both identifiers shall be set to the same value. If both identifiers match when a file reference is resolved, it is very likely that the correct and unchanged file has been found. If only the first identifier matches, a different version of the correct file has been found. see §14.4 "File Identifiers". """ if self._ID: id1 = self._ID[0] id2 = self._compute_document_identifier() else: id1 = self._compute_document_identifier() id2 = id1 self._ID = ArrayObject((id1, id2)) def encrypt( self, user_password: str, owner_password: Optional[str] = None, use_128bit: bool = True, permissions_flag: UserAccessPermissions = ALL_DOCUMENT_PERMISSIONS, *, algorithm: Optional[str] = None, ) -> None: """ Encrypt this PDF file with the PDF Standard encryption handler. Args: user_password: The password which allows for opening and reading the PDF file with the restrictions provided. owner_password: The password which allows for opening the PDF files without any restrictions. By default, the owner password is the same as the user password. use_128bit: flag as to whether to use 128bit encryption. When false, 40bit encryption will be used. By default, this flag is on. permissions_flag: permissions as described in Table 3.20 of the PDF 1.7 specification. A bit value of 1 means the permission is granted. Hence an integer value of -1 will set all flags. Bit position 3 is for printing, 4 is for modifying content, 5 and 6 control annotations, 9 for form fields, 10 for extraction of text and graphics. algorithm: encrypt algorithm. Values may be one of "RC4-40", "RC4-128", "AES-128", "AES-256-R5", "AES-256". If it is valid, `use_128bit` will be ignored. """ if owner_password is None: owner_password = user_password if algorithm is not None: try: alg = getattr(EncryptAlgorithm, algorithm.replace("-", "_")) except AttributeError: raise ValueError(f"Algorithm '{algorithm}' NOT supported") else: alg = EncryptAlgorithm.RC4_128 if not use_128bit: alg = EncryptAlgorithm.RC4_40 self.generate_file_identifiers() assert self._ID self._encryption = Encryption.make(alg, permissions_flag, self._ID[0]) # in case call `encrypt` again entry = self._encryption.write_entry(user_password, owner_password) if self._encrypt_entry: # replace old encrypt_entry assert self._encrypt_entry.indirect_reference is not None entry.indirect_reference = self._encrypt_entry.indirect_reference self._objects[entry.indirect_reference.idnum - 1] = entry else: self._add_object(entry) self._encrypt_entry = entry def _resolve_links(self) -> None: """Patch up links that were added to the document earlier, to make sure they still point to the same pages. """ for (new_link, old_link) in self._unresolved_links: old_page = old_link.find_referenced_page() if not old_page: continue new_page = self._merged_in_pages.get(old_page) if new_page is None: continue new_link.patch_reference(self, new_page) def write_stream(self, stream: StreamType) -> None: if hasattr(stream, "mode") and "b" not in stream.mode: logger_warning( f"File <{stream.name}> to write to is not in binary mode. " "It may not be written to correctly.", __name__, ) self._resolve_links() if self.incremental: self._reader.stream.seek(0) stream.write(self._reader.stream.read(-1)) if len(self.list_objects_in_increment()) > 0: self._write_increment(stream) # writes objs, xref stream and startxref else: object_positions, free_objects = self._write_pdf_structure(stream) xref_location = self._write_xref_table( stream, object_positions, free_objects ) self._write_trailer(stream, xref_location) def write(self, stream: Union[Path, StrByteType]) -> tuple[bool, IO[Any]]: """ Write the collection of pages added to this object out as a PDF file. Args: stream: An object to write the file to. The object can support the write method and the tell method, similar to a file object, or be a file path, just like the fileobj, just named it stream to keep existing workflow. Returns: A tuple (bool, IO). """ my_file = False if stream == "": raise ValueError(f"Output({stream=}) is empty.") if isinstance(stream, (str, Path)): stream = FileIO(stream, "wb") my_file = True self.write_stream(stream) if my_file: stream.close() else: stream.flush() return my_file, stream def list_objects_in_increment(self) -> list[IndirectObject]: """ For analysis or debugging. Provides the list of new or modified objects that will be written in the increment. Deleted objects will not be freed but will become orphans. Returns: List of new or modified IndirectObjects """ original_hash_count = len(self._original_hash) return [ cast(IndirectObject, obj).indirect_reference for i, obj in enumerate(self._objects) if ( obj is not None and ( i >= original_hash_count or obj.hash_bin() != self._original_hash[i] ) ) ] def _write_increment(self, stream: StreamType) -> None: object_positions = {} object_blocks = [] current_start = -1 current_stop = -2 original_hash_count = len(self._original_hash) for i, obj in enumerate(self._objects): if obj is not None and ( i >= original_hash_count or obj.hash_bin() != self._original_hash[i] ): idnum = i + 1 assert isinstance(obj, PdfObject), "mypy" # first write new/modified object object_positions[idnum] = stream.tell() stream.write(f"{idnum} 0 obj\n".encode()) """ encryption is not operational if self._encryption and obj != self._encrypt_entry: obj = self._encryption.encrypt_object(obj, idnum, 0) """ obj.write_to_stream(stream) stream.write(b"\nendobj\n") # prepare xref if idnum != current_stop: if current_start > 0: object_blocks.append( [current_start, current_stop - current_start] ) current_start = idnum current_stop = idnum + 1 assert current_start > 0, "for pytest only" object_blocks.append([current_start, current_stop - current_start]) # write incremented xref xref_location = stream.tell() xr_id = len(self._objects) + 1 stream.write(f"{xr_id} 0 obj".encode()) init_data = { NameObject("/Type"): NameObject("/XRef"), NameObject("/Size"): NumberObject(xr_id + 1), NameObject("/Root"): self.root_object.indirect_reference, NameObject("/Filter"): NameObject("/FlateDecode"), NameObject("/Index"): ArrayObject( [NumberObject(_it) for _su in object_blocks for _it in _su] ), NameObject("/W"): ArrayObject( [NumberObject(1), NumberObject(4), NumberObject(1)] ), "__streamdata__": b"", } if self._info is not None and ( self._info.indirect_reference.idnum - 1 # type: ignore >= len(self._original_hash) or cast(IndirectObject, self._info).hash_bin() # kept for future != self._original_hash[ self._info.indirect_reference.idnum - 1 # type: ignore ] ): init_data[NameObject(TK.INFO)] = self._info.indirect_reference init_data[NameObject(TK.PREV)] = NumberObject(self._reader._startxref) if self._ID: init_data[NameObject(TK.ID)] = self._ID xr = StreamObject.initialize_from_dictionary(init_data) xr.set_data( b"".join( [struct.pack(b">BIB", 1, _pos, 0) for _pos in object_positions.values()] ) ) xr.write_to_stream(stream) stream.write(f"\nendobj\nstartxref\n{xref_location}\n%%EOF\n".encode()) # eof def _write_pdf_structure(self, stream: StreamType) -> tuple[list[int], list[int]]: object_positions = [] free_objects = [] stream.write(self.pdf_header.encode() + b"\n") stream.write(b"%\xE2\xE3\xCF\xD3\n") for idnum, obj in enumerate(self._objects, start=1): if obj is not None: object_positions.append(stream.tell()) stream.write(f"{idnum} 0 obj\n".encode()) if self._encryption and obj != self._encrypt_entry: obj = self._encryption.encrypt_object(obj, idnum, 0) obj.write_to_stream(stream) stream.write(b"\nendobj\n") else: object_positions.append(-1) free_objects.append(idnum) free_objects.append(0) # add 0 to loop in accordance with specification return object_positions, free_objects def _write_xref_table( self, stream: StreamType, object_positions: list[int], free_objects: list[int] ) -> int: xref_location = stream.tell() stream.write(b"xref\n") stream.write(f"0 {len(self._objects) + 1}\n".encode()) stream.write(f"{free_objects[0]:0>10} {65535:0>5} f \n".encode()) free_idx = 1 for offset in object_positions: if offset > 0: stream.write(f"{offset:0>10} {0:0>5} n \n".encode()) else: stream.write(f"{free_objects[free_idx]:0>10} {1:0>5} f \n".encode()) free_idx += 1 return xref_location def _write_trailer(self, stream: StreamType, xref_location: int) -> None: """ Write the PDF trailer to the stream. To quote the PDF specification: [The] trailer [gives] the location of the cross-reference table and of certain special objects within the body of the file. """ stream.write(b"trailer\n") trailer = DictionaryObject( { NameObject(TK.SIZE): NumberObject(len(self._objects) + 1), NameObject(TK.ROOT): self.root_object.indirect_reference, } ) if self._info is not None: trailer[NameObject(TK.INFO)] = self._info.indirect_reference if self._ID is not None: trailer[NameObject(TK.ID)] = self._ID if self._encrypt_entry: trailer[NameObject(TK.ENCRYPT)] = self._encrypt_entry.indirect_reference trailer.write_to_stream(stream) stream.write(f"\nstartxref\n{xref_location}\n%%EOF\n".encode()) # eof @property def metadata(self) -> Optional[DocumentInformation]: """ Retrieve/set the PDF file's document information dictionary, if it exists. Args: value: dict with the entries to be set. if None : remove the /Info entry from the pdf. Note that some PDF files use (XMP) metadata streams instead of document information dictionaries, and these metadata streams will not be accessed by this function, but by :meth:`~xmp_metadata`. """ return super().metadata @metadata.setter def metadata( self, value: Optional[Union[DocumentInformation, DictionaryObject, dict[Any, Any]]], ) -> None: if value is None: self._info = None else: if self._info is not None: self._info.clear() self.add_metadata(value) def add_metadata(self, infos: dict[str, Any]) -> None: """ Add custom metadata to the output. Args: infos: a Python dictionary where each key is a field and each value is your new metadata. """ args = {} if isinstance(infos, PdfObject): infos = cast(DictionaryObject, infos.get_object()) for key, value in list(infos.items()): if isinstance(value, PdfObject): value = value.get_object() args[NameObject(key)] = create_string_object(str(value)) if self._info is None: self._info = DictionaryObject() self._info.update(args) def compress_identical_objects( self, remove_identicals: bool = True, remove_orphans: bool = True, ) -> None: """ Parse the PDF file and merge objects that have the same hash. This will make objects common to multiple pages. Recommended to be used just before writing output. Args: remove_identicals: Remove identical objects. remove_orphans: Remove unreferenced objects. """ def replace_in_obj( obj: PdfObject, crossref: dict[IndirectObject, IndirectObject] ) -> None: if isinstance(obj, DictionaryObject): key_val = obj.items() elif isinstance(obj, ArrayObject): key_val = enumerate(obj) # type: ignore else: return assert isinstance(obj, (DictionaryObject, ArrayObject)) for k, v in key_val: if isinstance(v, IndirectObject): orphans[v.idnum - 1] = False if v in crossref: obj[k] = crossref[v] else: """the filtering on DictionaryObject and ArrayObject only will be performed within replace_in_obj""" replace_in_obj(v, crossref) # _idnum_hash :dict[hash]=(1st_ind_obj,[other_indir_objs,...]) self._idnum_hash = {} orphans = [True] * len(self._objects) # look for similar objects for idx, obj in enumerate(self._objects): if is_null_or_none(obj): continue assert obj is not None, "mypy" # mypy: TypeGuard of `is_null_or_none` does not help here. assert isinstance(obj.indirect_reference, IndirectObject) h = obj.hash_value() if remove_identicals and h in self._idnum_hash: self._idnum_hash[h][1].append(obj.indirect_reference) self._objects[idx] = None else: self._idnum_hash[h] = (obj.indirect_reference, []) # generate the dict converting others to 1st cnv = {v[0]: v[1] for v in self._idnum_hash.values() if len(v[1]) > 0} cnv_rev: dict[IndirectObject, IndirectObject] = {} for k, v in cnv.items(): cnv_rev.update(zip(v, (k,) * len(v))) # replace reference to merged objects for obj in self._objects: if isinstance(obj, (DictionaryObject, ArrayObject)): replace_in_obj(obj, cnv_rev) # remove orphans (if applicable) orphans[self.root_object.indirect_reference.idnum - 1] = False # type: ignore orphans[self._info.indirect_reference.idnum - 1] = False # type: ignore try: orphans[self._ID.indirect_reference.idnum - 1] = False # type: ignore except AttributeError: pass for i in compress(range(len(self._objects)), orphans): self._objects[i] = None def get_reference(self, obj: PdfObject) -> IndirectObject: idnum = self._objects.index(obj) + 1 ref = IndirectObject(idnum, 0, self) assert ref.get_object() == obj return ref def get_outline_root(self) -> TreeObject: if CO.OUTLINES in self._root_object: # Entries in the catalog dictionary outline = cast(TreeObject, self._root_object[CO.OUTLINES]) if not isinstance(outline, TreeObject): t = TreeObject(outline) self._replace_object(outline.indirect_reference.idnum, t) outline = t idnum = self._objects.index(outline) + 1 outline_ref = IndirectObject(idnum, 0, self) assert outline_ref.get_object() == outline else: outline = TreeObject() outline.update({}) outline_ref = self._add_object(outline) self._root_object[NameObject(CO.OUTLINES)] = outline_ref return outline def get_threads_root(self) -> ArrayObject: """ The list of threads. See §12.4.3 of the PDF 1.7 or PDF 2.0 specification. Returns: An array (possibly empty) of Dictionaries with an ``/F`` key, and optionally information about the thread in ``/I`` or ``/Metadata`` keys. """ if CO.THREADS in self._root_object: # Entries in the catalog dictionary threads = cast(ArrayObject, self._root_object[CO.THREADS]) else: threads = ArrayObject() self._root_object[NameObject(CO.THREADS)] = threads return threads @property def threads(self) -> ArrayObject: """ Read-only property for the list of threads. See §12.4.3 of the PDF 1.7 or PDF 2.0 specification. Each element is a dictionary with an ``/F`` key, and optionally information about the thread in ``/I`` or ``/Metadata`` keys. """ return self.get_threads_root() def add_outline_item_destination( self, page_destination: Union[IndirectObject, PageObject, TreeObject], parent: Union[None, TreeObject, IndirectObject] = None, before: Union[None, TreeObject, IndirectObject] = None, is_open: bool = True, ) -> IndirectObject: page_destination = cast(PageObject, page_destination.get_object()) if isinstance(page_destination, PageObject): return self.add_outline_item_destination( Destination( f"page #{page_destination.page_number}", cast(IndirectObject, page_destination.indirect_reference), Fit.fit(), ) ) if parent is None: parent = self.get_outline_root() page_destination[NameObject("/%is_open%")] = BooleanObject(is_open) parent = cast(TreeObject, parent.get_object()) page_destination_ref = self._add_object(page_destination) if before is not None: before = before.indirect_reference parent.insert_child( page_destination_ref, before, self, page_destination.inc_parent_counter_outline if is_open else (lambda x, y: 0), # noqa: ARG005 ) if "/Count" not in page_destination: page_destination[NameObject("/Count")] = NumberObject(0) return page_destination_ref def add_outline_item_dict( self, outline_item: OutlineItemType, parent: Union[None, TreeObject, IndirectObject] = None, before: Union[None, TreeObject, IndirectObject] = None, is_open: bool = True, ) -> IndirectObject: outline_item_object = TreeObject() outline_item_object.update(outline_item) """code currently unreachable if "/A" in outline_item: action = DictionaryObject() a_dict = cast(DictionaryObject, outline_item["/A"]) for k, v in list(a_dict.items()): action[NameObject(str(k))] = v action_ref = self._add_object(action) outline_item_object[NameObject("/A")] = action_ref """ return self.add_outline_item_destination( outline_item_object, parent, before, is_open ) def add_outline_item( self, title: str, page_number: Union[None, PageObject, IndirectObject, int], parent: Union[None, TreeObject, IndirectObject] = None, before: Union[None, TreeObject, IndirectObject] = None, color: Optional[Union[tuple[float, float, float], str]] = None, bold: bool = False, italic: bool = False, fit: Fit = PAGE_FIT, is_open: bool = True, ) -> IndirectObject: """ Add an outline item (commonly referred to as a "Bookmark") to the PDF file. Args: title: Title to use for this outline item. page_number: Page number this outline item will point to. parent: A reference to a parent outline item to create nested outline items. before: color: Color of the outline item's font as a red, green, blue tuple from 0.0 to 1.0 or as a Hex String (#RRGGBB) bold: Outline item font is bold italic: Outline item font is italic fit: The fit of the destination page. Returns: The added outline item as an indirect object. """ page_ref: Union[None, NullObject, IndirectObject, NumberObject] if isinstance(italic, Fit): # it means that we are on the old params if fit is not None and page_number is None: page_number = fit return self.add_outline_item( title, page_number, parent, None, before, color, bold, italic, is_open=is_open ) if page_number is None: action_ref = None else: if isinstance(page_number, IndirectObject): page_ref = page_number elif isinstance(page_number, PageObject): page_ref = page_number.indirect_reference elif isinstance(page_number, int): try: page_ref = self.pages[page_number].indirect_reference except IndexError: page_ref = NumberObject(page_number) if page_ref is None: logger_warning( f"can not find reference of page {page_number}", __name__, ) page_ref = NullObject() dest = Destination( NameObject("/" + title + " outline item"), page_ref, fit, ) action_ref = self._add_object( DictionaryObject( { NameObject(GoToActionArguments.D): dest.dest_array, NameObject(GoToActionArguments.S): NameObject("/GoTo"), } ) ) outline_item = self._add_object( _create_outline_item(action_ref, title, color, italic, bold) ) if parent is None: parent = self.get_outline_root() return self.add_outline_item_destination(outline_item, parent, before, is_open) def add_outline(self) -> None: raise NotImplementedError( "This method is not yet implemented. Use :meth:`add_outline_item` instead." ) def add_named_destination_array( self, title: TextStringObject, destination: Union[IndirectObject, ArrayObject] ) -> None: named_dest = self.get_named_dest_root() i = 0 while i < len(named_dest): if title < named_dest[i]: named_dest.insert(i, destination) named_dest.insert(i, TextStringObject(title)) return i += 2 named_dest.extend([TextStringObject(title), destination]) return def add_named_destination_object( self, page_destination: PdfObject, ) -> IndirectObject: page_destination_ref = self._add_object(page_destination.dest_array) # type: ignore self.add_named_destination_array( cast("TextStringObject", page_destination["/Title"]), page_destination_ref # type: ignore ) return page_destination_ref def add_named_destination( self, title: str, page_number: int, ) -> IndirectObject: page_ref = self.get_object(self._pages)[PagesAttributes.KIDS][page_number] # type: ignore dest = DictionaryObject() dest.update( { NameObject(GoToActionArguments.D): ArrayObject( [page_ref, NameObject(TypFitArguments.FIT_H), NumberObject(826)] ), NameObject(GoToActionArguments.S): NameObject("/GoTo"), } ) dest_ref = self._add_object(dest) if not isinstance(title, TextStringObject): title = TextStringObject(str(title)) self.add_named_destination_array(title, dest_ref) return dest_ref def remove_links(self) -> None: """Remove links and annotations from this output.""" for page in self.pages: self.remove_objects_from_page(page, ObjectDeletionFlag.ALL_ANNOTATIONS) def remove_annotations( self, subtypes: Optional[Union[AnnotationSubtype, Iterable[AnnotationSubtype]]] ) -> None: """ Remove annotations by annotation subtype. Args: subtypes: subtype or list of subtypes to be removed. Examples are: "/Link", "/FileAttachment", "/Sound", "/Movie", "/Screen", ... If you want to remove all annotations, use subtypes=None. """ for page in self.pages: self._remove_annots_from_page(page, subtypes) def _remove_annots_from_page( self, page: Union[IndirectObject, PageObject, DictionaryObject], subtypes: Optional[Iterable[str]], ) -> None: page = cast(DictionaryObject, page.get_object()) if PG.ANNOTS in page: i = 0 while i < len(cast(ArrayObject, page[PG.ANNOTS])): an = cast(ArrayObject, page[PG.ANNOTS])[i] obj = cast(DictionaryObject, an.get_object()) if subtypes is None or cast(str, obj["/Subtype"]) in subtypes: if isinstance(an, IndirectObject): self._objects[an.idnum - 1] = NullObject() # to reduce PDF size del page[PG.ANNOTS][i] # type:ignore else: i += 1 def remove_objects_from_page( self, page: Union[PageObject, DictionaryObject], to_delete: Union[ObjectDeletionFlag, Iterable[ObjectDeletionFlag]], text_filters: Optional[dict[str, Any]] = None ) -> None: """ Remove objects specified by ``to_delete`` from the given page. Args: page: Page object to clean up. to_delete: Objects to be deleted; can be a ``ObjectDeletionFlag`` or a list of ObjectDeletionFlag text_filters: Properties of text to be deleted, if applicable. Optional. This is a Python dictionary with the following properties: * font_ids: List of font resource IDs (such as /F1 or /T1_0) to be deleted. """ if isinstance(to_delete, (list, tuple)): for to_d in to_delete: self.remove_objects_from_page(page, to_d) return None assert isinstance(to_delete, ObjectDeletionFlag) if to_delete & ObjectDeletionFlag.LINKS: return self._remove_annots_from_page(page, ("/Link",)) if to_delete & ObjectDeletionFlag.ATTACHMENTS: return self._remove_annots_from_page( page, ("/FileAttachment", "/Sound", "/Movie", "/Screen") ) if to_delete & ObjectDeletionFlag.OBJECTS_3D: return self._remove_annots_from_page(page, ("/3D",)) if to_delete & ObjectDeletionFlag.ALL_ANNOTATIONS: return self._remove_annots_from_page(page, None) jump_operators = [] if to_delete & ObjectDeletionFlag.DRAWING_IMAGES: jump_operators = ( [ b"w", b"J", b"j", b"M", b"d", b"i", b"W", b"W*", b"b", b"b*", b"B", b"B*", b"S", b"s", b"f", b"f*", b"F", b"n", b"m", b"l", b"c", b"v", b"y", b"h", b"re", b"sh" ] ) if to_delete & ObjectDeletionFlag.TEXT: jump_operators = [b"Tj", b"TJ", b"'", b'"'] def clean( content: ContentStream, images: list[str], forms: list[str], text_filters: Optional[dict[str, Any]] = None ) -> None: nonlocal jump_operators, to_delete font_id = None font_ids_to_delete = [] if text_filters and to_delete & ObjectDeletionFlag.TEXT: font_ids_to_delete = text_filters.get("font_ids", []) i = 0 while i < len(content.operations): operands, operator = content.operations[i] if operator == b"Tf": font_id = operands[0] if ( ( operator == b"INLINE IMAGE" and (to_delete & ObjectDeletionFlag.INLINE_IMAGES) ) or (operator in jump_operators) or ( operator == b"Do" and (to_delete & ObjectDeletionFlag.XOBJECT_IMAGES) and (operands[0] in images) ) ): if ( not to_delete & ObjectDeletionFlag.TEXT or (to_delete & ObjectDeletionFlag.TEXT and not text_filters) or (to_delete & ObjectDeletionFlag.TEXT and font_id in font_ids_to_delete) ): del content.operations[i] else: i += 1 else: i += 1 content.get_data() # this ensures ._data is rebuilt from the .operations def clean_forms( elt: DictionaryObject, stack: list[DictionaryObject] ) -> tuple[list[str], list[str]]: nonlocal to_delete # elt in recursive call is a new ContentStream object, so we have to check the indirect_reference if (elt in stack) or ( hasattr(elt, "indirect_reference") and any( elt.indirect_reference == getattr(x, "indirect_reference", -1) for x in stack ) ): # to prevent infinite looping return [], [] # pragma: no cover try: d = cast( dict[Any, Any], cast(DictionaryObject, elt["/Resources"])["/XObject"], ) except KeyError: d = {} images = [] forms = [] for k, v in d.items(): o = v.get_object() try: content: Any = None if ( to_delete & ObjectDeletionFlag.XOBJECT_IMAGES and o["/Subtype"] == "/Image" ): content = NullObject() # to delete the image keeping the entry images.append(k) if o["/Subtype"] == "/Form": forms.append(k) if isinstance(o, ContentStream): content = o else: content = ContentStream(o, self) content.update( { k1: v1 for k1, v1 in o.items() if k1 not in ["/Length", "/Filter", "/DecodeParms"] } ) try: content.indirect_reference = o.indirect_reference except AttributeError: # pragma: no cover pass stack.append(elt) clean_forms(content, stack) # clean subforms if content is not None: if isinstance(v, IndirectObject): self._objects[v.idnum - 1] = content else: # should only occur in a PDF not respecting PDF spec # where streams must be indirected. d[k] = self._add_object(content) # pragma: no cover except (TypeError, KeyError): pass for im in images: del d[im] # for clean-up if isinstance(elt, StreamObject): # for /Form if not isinstance(elt, ContentStream): # pragma: no cover e = ContentStream(elt, self) e.update(elt.items()) elt = e clean(elt, images, forms, text_filters) # clean the content return images, forms if not isinstance(page, PageObject): page = PageObject(self, page.indirect_reference) # pragma: no cover if "/Contents" in page: content = cast(ContentStream, page.get_contents()) images, forms = clean_forms(page, []) clean(content, images, forms, text_filters) page.replace_contents(content) def remove_images( self, to_delete: ImageType = ImageType.ALL, ) -> None: """ Remove images from this output. Args: to_delete: The type of images to be deleted (default = all images types) """ if isinstance(to_delete, bool): to_delete = ImageType.ALL i = ObjectDeletionFlag.NONE for image in ("XOBJECT_IMAGES", "INLINE_IMAGES", "DRAWING_IMAGES"): if to_delete & ImageType[image]: i |= ObjectDeletionFlag[image] for page in self.pages: self.remove_objects_from_page(page, i) def remove_text(self, font_names: Optional[list[str]] = None) -> None: """ Remove text from the PDF. Args: font_names: List of font names to remove, such as "Helvetica-Bold". Optional. If not specified, all text will be removed. """ if not font_names: font_names = [] for page in self.pages: resource_ids_to_remove = [] # Content streams reference fonts and other resources with names like "/F1" or "/T1_0" # Font names need to be converted to resource names/IDs for easier removal if font_names: # Recursively loop through page objects to gather font info def get_font_info( obj: Any, font_info: Optional[dict[str, Any]] = None, key: Optional[str] = None ) -> dict[str, Any]: if font_info is None: font_info = {} if isinstance(obj, IndirectObject): obj = obj.get_object() if isinstance(obj, dict): if obj.get("/Type") == "/Font": font_name = obj.get("/BaseFont", "") # Normalize font names like "/RRXFFV+Palatino-Bold" to "Palatino-Bold" normalized_font_name = font_name.lstrip("/").split("+")[-1] if normalized_font_name not in font_info: font_info[normalized_font_name] = { "normalized_font_name": normalized_font_name, "resource_ids": [], } if key not in font_info[normalized_font_name]["resource_ids"]: font_info[normalized_font_name]["resource_ids"].append(key) for k in obj: font_info = get_font_info(obj[k], font_info, k) elif isinstance(obj, (list, ArrayObject)): for child_obj in obj: font_info = get_font_info(child_obj, font_info) return font_info # Add relevant resource names for removal font_info = get_font_info(page.get("/Resources")) for font_name in font_names: if font_name in font_info: resource_ids_to_remove.extend(font_info[font_name]["resource_ids"]) text_filters = {} if font_names: text_filters["font_ids"] = resource_ids_to_remove self.remove_objects_from_page(page, ObjectDeletionFlag.TEXT, text_filters=text_filters) def add_uri( self, page_number: int, uri: str, rect: RectangleObject, border: Optional[ArrayObject] = None, ) -> None: """ Add an URI from a rectangular area to the specified page. Args: page_number: index of the page on which to place the URI action. uri: URI of resource to link to. rect: :class:`RectangleObject` or array of four integers specifying the clickable rectangular area ``[xLL, yLL, xUR, yUR]``, or string in the form ``"[ xLL yLL xUR yUR ]"``. border: if provided, an array describing border-drawing properties. See the PDF spec for details. No border will be drawn if this argument is omitted. """ page_link = self.get_object(self._pages)[PagesAttributes.KIDS][page_number] # type: ignore page_ref = cast(dict[str, Any], self.get_object(page_link)) border_arr: BorderArrayType if border is not None: border_arr = [NumberObject(n) for n in border[:3]] if len(border) == 4: dash_pattern = ArrayObject([NumberObject(n) for n in border[3]]) border_arr.append(dash_pattern) else: border_arr = [NumberObject(2), NumberObject(2), NumberObject(2)] if isinstance(rect, str): rect = NumberObject(rect) elif isinstance(rect, RectangleObject): pass else: rect = RectangleObject(rect) lnk2 = DictionaryObject() lnk2.update( { NameObject("/S"): NameObject("/URI"), NameObject("/URI"): TextStringObject(uri), } ) lnk = DictionaryObject() lnk.update( { NameObject(AA.Type): NameObject("/Annot"), NameObject(AA.Subtype): NameObject("/Link"), NameObject(AA.P): page_link, NameObject(AA.Rect): rect, NameObject("/H"): NameObject("/I"), NameObject(AA.Border): ArrayObject(border_arr), NameObject("/A"): lnk2, } ) lnk_ref = self._add_object(lnk) if PG.ANNOTS in page_ref: page_ref[PG.ANNOTS].append(lnk_ref) else: page_ref[NameObject(PG.ANNOTS)] = ArrayObject([lnk_ref]) _valid_layouts = ( "/NoLayout", "/SinglePage", "/OneColumn", "/TwoColumnLeft", "/TwoColumnRight", "/TwoPageLeft", "/TwoPageRight", ) def _get_page_layout(self) -> Optional[LayoutType]: try: return cast(LayoutType, self._root_object["/PageLayout"]) except KeyError: return None def _set_page_layout(self, layout: Union[NameObject, LayoutType]) -> None: """ Set the page layout. Args: layout: The page layout to be used. .. list-table:: Valid ``layout`` arguments :widths: 50 200 * - /NoLayout - Layout explicitly not specified * - /SinglePage - Show one page at a time * - /OneColumn - Show one column at a time * - /TwoColumnLeft - Show pages in two columns, odd-numbered pages on the left * - /TwoColumnRight - Show pages in two columns, odd-numbered pages on the right * - /TwoPageLeft - Show two pages at a time, odd-numbered pages on the left * - /TwoPageRight - Show two pages at a time, odd-numbered pages on the right """ if not isinstance(layout, NameObject): if layout not in self._valid_layouts: logger_warning( f"Layout should be one of: {'', ''.join(self._valid_layouts)}", __name__, ) layout = NameObject(layout) self._root_object.update({NameObject("/PageLayout"): layout}) def set_page_layout(self, layout: LayoutType) -> None: """ Set the page layout. Args: layout: The page layout to be used .. list-table:: Valid ``layout`` arguments :widths: 50 200 * - /NoLayout - Layout explicitly not specified * - /SinglePage - Show one page at a time * - /OneColumn - Show one column at a time * - /TwoColumnLeft - Show pages in two columns, odd-numbered pages on the left * - /TwoColumnRight - Show pages in two columns, odd-numbered pages on the right * - /TwoPageLeft - Show two pages at a time, odd-numbered pages on the left * - /TwoPageRight - Show two pages at a time, odd-numbered pages on the right """ self._set_page_layout(layout) @property def page_layout(self) -> Optional[LayoutType]: """ Page layout property. .. list-table:: Valid ``layout`` values :widths: 50 200 * - /NoLayout - Layout explicitly not specified * - /SinglePage - Show one page at a time * - /OneColumn - Show one column at a time * - /TwoColumnLeft - Show pages in two columns, odd-numbered pages on the left * - /TwoColumnRight - Show pages in two columns, odd-numbered pages on the right * - /TwoPageLeft - Show two pages at a time, odd-numbered pages on the left * - /TwoPageRight - Show two pages at a time, odd-numbered pages on the right """ return self._get_page_layout() @page_layout.setter def page_layout(self, layout: LayoutType) -> None: self._set_page_layout(layout) _valid_modes = ( "/UseNone", "/UseOutlines", "/UseThumbs", "/FullScreen", "/UseOC", "/UseAttachments", ) def _get_page_mode(self) -> Optional[PagemodeType]: try: return cast(PagemodeType, self._root_object["/PageMode"]) except KeyError: return None @property def page_mode(self) -> Optional[PagemodeType]: """ Page mode property. .. list-table:: Valid ``mode`` values :widths: 50 200 * - /UseNone - Do not show outline or thumbnails panels * - /UseOutlines - Show outline (aka bookmarks) panel * - /UseThumbs - Show page thumbnails panel * - /FullScreen - Fullscreen view * - /UseOC - Show Optional Content Group (OCG) panel * - /UseAttachments - Show attachments panel """ return self._get_page_mode() @page_mode.setter def page_mode(self, mode: PagemodeType) -> None: if isinstance(mode, NameObject): mode_name: NameObject = mode else: if mode not in self._valid_modes: logger_warning( f"Mode should be one of: {', '.join(self._valid_modes)}", __name__ ) mode_name = NameObject(mode) self._root_object.update({NameObject("/PageMode"): mode_name}) def add_annotation( self, page_number: Union[int, PageObject], annotation: dict[str, Any], ) -> DictionaryObject: """ Add a single annotation to the page. The added annotation must be a new annotation. It cannot be recycled. Args: page_number: PageObject or page index. annotation: Annotation to be added (created with annotation). Returns: The inserted object. This can be used for popup creation, for example. """ page = page_number if isinstance(page, int): page = self.pages[page] elif not isinstance(page, PageObject): raise TypeError("page: invalid type") to_add = cast(DictionaryObject, _pdf_objectify(annotation)) to_add[NameObject("/P")] = page.indirect_reference if page.annotations is None: page[NameObject("/Annots")] = ArrayObject() assert page.annotations is not None # Internal link annotations need the correct object type for the # destination if to_add.get("/Subtype") == "/Link" and "/Dest" in to_add: tmp = cast(dict[Any, Any], to_add[NameObject("/Dest")]) dest = Destination( NameObject("/LinkName"), tmp["target_page_index"], Fit( fit_type=tmp["fit"], fit_args=dict(tmp)["fit_args"] ), # I have no clue why this dict-hack is necessary ) to_add[NameObject("/Dest")] = dest.dest_array page.annotations.append(self._add_object(to_add)) if to_add.get("/Subtype") == "/Popup" and NameObject("/Parent") in to_add: cast(DictionaryObject, to_add["/Parent"].get_object())[ NameObject("/Popup") ] = to_add.indirect_reference return to_add def clean_page(self, page: Union[PageObject, IndirectObject]) -> PageObject: """ Perform some clean up in the page. Currently: convert NameObject named destination to TextStringObject (required for names/dests list) Args: page: Returns: The cleaned PageObject """ page = cast("PageObject", page.get_object()) for a in page.get("/Annots", []): a_obj = a.get_object() d = a_obj.get("/Dest", None) act = a_obj.get("/A", None) if isinstance(d, NameObject): a_obj[NameObject("/Dest")] = TextStringObject(d) elif act is not None: act = act.get_object() d = act.get("/D", None) if isinstance(d, NameObject): act[NameObject("/D")] = TextStringObject(d) return page def _create_stream( self, fileobj: Union[Path, StrByteType, PdfReader] ) -> tuple[IOBase, Optional[Encryption]]: # If the fileobj parameter is a string, assume it is a path # and create a file object at that location. If it is a file, # copy the file's contents into a BytesIO stream object; if # it is a PdfReader, copy that reader's stream into a # BytesIO stream. # If fileobj is none of the above types, it is not modified encryption_obj = None stream: IOBase if isinstance(fileobj, (str, Path)): with FileIO(fileobj, "rb") as f: stream = BytesIO(f.read()) elif isinstance(fileobj, PdfReader): if fileobj._encryption: encryption_obj = fileobj._encryption orig_tell = fileobj.stream.tell() fileobj.stream.seek(0) stream = BytesIO(fileobj.stream.read()) # reset the stream to its original location fileobj.stream.seek(orig_tell) elif hasattr(fileobj, "seek") and hasattr(fileobj, "read"): fileobj.seek(0) filecontent = fileobj.read() stream = BytesIO(filecontent) else: raise NotImplementedError( "Merging requires an object that PdfReader can parse. " "Typically, that is a Path or a string representing a Path, " "a file object, or an object implementing .seek and .read. " "Passing a PdfReader directly works as well." ) return stream, encryption_obj def append( self, fileobj: Union[StrByteType, PdfReader, Path], outline_item: Union[ str, None, PageRange, tuple[int, int], tuple[int, int, int], list[int] ] = None, pages: Union[ None, PageRange, tuple[int, int], tuple[int, int, int], list[int], list[PageObject], ] = None, import_outline: bool = True, excluded_fields: Optional[Union[list[str], tuple[str, ...]]] = None, ) -> None: """ Identical to the :meth:`merge()` method, but assumes you want to concatenate all pages onto the end of the file instead of specifying a position. Args: fileobj: A File Object or an object that supports the standard read and seek methods similar to a File Object. Could also be a string representing a path to a PDF file. outline_item: Optionally, you may specify a string to build an outline (aka 'bookmark') to identify the beginning of the included file. pages: Can be a :class:`PageRange` or a ``(start, stop[, step])`` tuple or a list of pages to be processed to merge only the specified range of pages from the source document into the output document. import_outline: You may prevent the source document's outline (collection of outline items, previously referred to as 'bookmarks') from being imported by specifying this as ``False``. excluded_fields: Provide the list of fields/keys to be ignored if ``/Annots`` is part of the list, the annotation will be ignored if ``/B`` is part of the list, the articles will be ignored """ if excluded_fields is None: excluded_fields = () if isinstance(outline_item, (tuple, list, PageRange)): if isinstance(pages, bool): if not isinstance(import_outline, bool): excluded_fields = import_outline import_outline = pages pages = outline_item self.merge( None, fileobj, None, pages, import_outline, excluded_fields, ) else: # if isinstance(outline_item, str): self.merge( None, fileobj, outline_item, pages, import_outline, excluded_fields, ) def merge( self, position: Optional[int], fileobj: Union[Path, StrByteType, PdfReader], outline_item: Optional[str] = None, pages: Optional[Union[PageRangeSpec, list[PageObject]]] = None, import_outline: bool = True, excluded_fields: Optional[Union[list[str], tuple[str, ...]]] = (), ) -> None: """ Merge the pages from the given file into the output file at the specified page number. Args: position: The *page number* to insert this file. File will be inserted after the given number. fileobj: A File Object or an object that supports the standard read and seek methods similar to a File Object. Could also be a string representing a path to a PDF file. outline_item: Optionally, you may specify a string to build an outline (aka 'bookmark') to identify the beginning of the included file. pages: can be a :class:`PageRange` or a ``(start, stop[, step])`` tuple or a list of pages to be processed to merge only the specified range of pages from the source document into the output document. import_outline: You may prevent the source document's outline (collection of outline items, previously referred to as 'bookmarks') from being imported by specifying this as ``False``. excluded_fields: provide the list of fields/keys to be ignored if ``/Annots`` is part of the list, the annotation will be ignored if ``/B`` is part of the list, the articles will be ignored Raises: TypeError: The pages attribute is not configured properly """ if isinstance(fileobj, PdfDocCommon): reader = fileobj else: stream, _encryption_obj = self._create_stream(fileobj) # Create a new PdfReader instance using the stream # (either file or BytesIO or StringIO) created above reader = PdfReader(stream, strict=False) # type: ignore[arg-type] if excluded_fields is None: excluded_fields = () # Find the range of pages to merge. if pages is None: pages = list(range(len(reader.pages))) elif isinstance(pages, PageRange): pages = list(range(*pages.indices(len(reader.pages)))) elif isinstance(pages, list): pass # keep unchanged elif isinstance(pages, tuple) and len(pages) <= 3: pages = list(range(*pages)) elif not isinstance(pages, tuple): raise TypeError( '"pages" must be a tuple of (start, stop[, step]) or a list' ) srcpages = {} for page in pages: if isinstance(page, PageObject): pg = page else: pg = reader.pages[page] assert pg.indirect_reference is not None if position is None: # numbers in the exclude list identifies that the exclusion is # only applicable to 1st level of cloning srcpages[pg.indirect_reference.idnum] = self.add_page( pg, [*list(excluded_fields), 1, "/B", 1, "/Annots"] # type: ignore ) else: srcpages[pg.indirect_reference.idnum] = self.insert_page( pg, position, [*list(excluded_fields), 1, "/B", 1, "/Annots"] # type: ignore ) position += 1 srcpages[pg.indirect_reference.idnum].original_page = pg reader._named_destinations = ( reader.named_destinations ) # need for the outline processing below arr: Any def _process_named_dests(dest: Any) -> None: arr = dest.dest_array if "/Names" in self._root_object and dest["/Title"] in cast( list[Any], cast( DictionaryObject, cast(DictionaryObject, self._root_object["/Names"]).get("/Dests", DictionaryObject()), ).get("/Names", DictionaryObject()), ): # already exists: should not duplicate it pass elif dest["/Page"] is None or isinstance(dest["/Page"], NullObject): pass elif isinstance(dest["/Page"], int): # the page reference is a page number normally not a PDF Reference # page numbers as int are normally accepted only in external goto try: p = reader.pages[dest["/Page"]] except IndexError: return assert p.indirect_reference is not None try: arr[NumberObject(0)] = NumberObject( srcpages[p.indirect_reference.idnum].page_number ) self.add_named_destination_array(dest["/Title"], arr) except KeyError: pass elif dest["/Page"].indirect_reference.idnum in srcpages: arr[NumberObject(0)] = srcpages[ dest["/Page"].indirect_reference.idnum ].indirect_reference self.add_named_destination_array(dest["/Title"], arr) for dest in reader._named_destinations.values(): _process_named_dests(dest) outline_item_typ: TreeObject if outline_item is not None: outline_item_typ = cast( "TreeObject", self.add_outline_item( TextStringObject(outline_item), next(iter(srcpages.values())).indirect_reference, fit=PAGE_FIT, ).get_object(), ) else: outline_item_typ = self.get_outline_root() _ro = reader.root_object if import_outline and CO.OUTLINES in _ro: outline = self._get_filtered_outline( _ro.get(CO.OUTLINES, None), srcpages, reader ) self._insert_filtered_outline( outline, outline_item_typ, None ) # TODO: use before parameter if "/Annots" not in excluded_fields: for pag in srcpages.values(): lst = self._insert_filtered_annotations( pag.original_page.get("/Annots", []), pag, srcpages, reader ) if len(lst) > 0: pag[NameObject("/Annots")] = lst self.clean_page(pag) if "/AcroForm" in _ro and _ro["/AcroForm"] is not None: if "/AcroForm" not in self._root_object: self._root_object[NameObject("/AcroForm")] = self._add_object( cast( DictionaryObject, reader.root_object["/AcroForm"], ).clone(self, False, ("/Fields",)) ) arr = ArrayObject() else: arr = cast( ArrayObject, cast(DictionaryObject, self._root_object["/AcroForm"])["/Fields"], ) trslat = self._id_translated[id(reader)] try: for f in reader.root_object["/AcroForm"]["/Fields"]: # type: ignore try: ind = IndirectObject(trslat[f.idnum], 0, self) if ind not in arr: arr.append(ind) except KeyError: # for trslat[] which mean the field has not be copied # through the page pass except KeyError: # for /Acroform or /Fields are not existing arr = self._add_object(ArrayObject()) cast(DictionaryObject, self._root_object["/AcroForm"])[ NameObject("/Fields") ] = arr if "/B" not in excluded_fields: self.add_filtered_articles("", srcpages, reader) def _add_articles_thread( self, thread: DictionaryObject, # thread entry from the reader's array of threads pages: dict[int, PageObject], reader: PdfReader, ) -> IndirectObject: """ Clone the thread with only the applicable articles. Args: thread: pages: reader: Returns: The added thread as an indirect reference """ nthread = thread.clone( self, force_duplicate=True, ignore_fields=("/F",) ) # use of clone to keep link between reader and writer self.threads.append(nthread.indirect_reference) first_article = cast("DictionaryObject", thread["/F"]) current_article: Optional[DictionaryObject] = first_article new_article: Optional[DictionaryObject] = None while current_article is not None: pag = self._get_cloned_page( cast("PageObject", current_article["/P"]), pages, reader ) if pag is not None: if new_article is None: new_article = cast( "DictionaryObject", self._add_object(DictionaryObject()).get_object(), ) new_first = new_article nthread[NameObject("/F")] = new_article.indirect_reference else: new_article2 = cast( "DictionaryObject", self._add_object( DictionaryObject( {NameObject("/V"): new_article.indirect_reference} ) ).get_object(), ) new_article[NameObject("/N")] = new_article2.indirect_reference new_article = new_article2 new_article[NameObject("/P")] = pag new_article[NameObject("/T")] = nthread.indirect_reference new_article[NameObject("/R")] = current_article["/R"] pag_obj = cast("PageObject", pag.get_object()) if "/B" not in pag_obj: pag_obj[NameObject("/B")] = ArrayObject() cast("ArrayObject", pag_obj["/B"]).append( new_article.indirect_reference ) current_article = cast("DictionaryObject", current_article["/N"]) if current_article == first_article: new_article[NameObject("/N")] = new_first.indirect_reference # type: ignore new_first[NameObject("/V")] = new_article.indirect_reference # type: ignore current_article = None assert nthread.indirect_reference is not None return nthread.indirect_reference def add_filtered_articles( self, fltr: Union[ Pattern[Any], str ], # thread entry from the reader's array of threads pages: dict[int, PageObject], reader: PdfReader, ) -> None: """ Add articles matching the defined criteria. Args: fltr: pages: reader: """ if isinstance(fltr, str): fltr = re.compile(fltr) elif not isinstance(fltr, Pattern): fltr = re.compile("") for p in pages.values(): pp = p.original_page for a in pp.get("/B", ()): thr = a.get_object().get("/T") if thr is None: continue thr = thr.get_object() if thr.indirect_reference.idnum not in self._id_translated[ id(reader) ] and fltr.search((thr.get("/I", {})).get("/Title", "")): self._add_articles_thread(thr, pages, reader) def _get_cloned_page( self, page: Union[None, IndirectObject, PageObject, NullObject], pages: dict[int, PageObject], reader: PdfReader, ) -> Optional[IndirectObject]: if isinstance(page, NullObject): return None if isinstance(page, DictionaryObject) and page.get("/Type", "") == "/Page": _i = page.indirect_reference elif isinstance(page, IndirectObject): _i = page try: return pages[_i.idnum].indirect_reference # type: ignore except Exception: return None def _insert_filtered_annotations( self, annots: Union[IndirectObject, list[DictionaryObject], None], page: PageObject, pages: dict[int, PageObject], reader: PdfReader, ) -> list[Destination]: outlist = ArrayObject() if isinstance(annots, IndirectObject): annots = cast("list[Any]", annots.get_object()) if annots is None: return outlist if not isinstance(annots, list): logger_warning(f"Expected list of annotations, got {annots} of type {annots.__class__.__name__}.", __name__) return outlist for an in annots: ano = cast("DictionaryObject", an.get_object()) if ( ano["/Subtype"] != "/Link" or "/A" not in ano or cast("DictionaryObject", ano["/A"])["/S"] != "/GoTo" or "/Dest" in ano ): if "/Dest" not in ano: outlist.append(self._add_object(ano.clone(self))) else: d = ano["/Dest"] if isinstance(d, str): # it is a named dest if str(d) in self.get_named_dest_root(): outlist.append(ano.clone(self).indirect_reference) else: d = cast("ArrayObject", d) p = self._get_cloned_page(d[0], pages, reader) if p is not None: anc = ano.clone(self, ignore_fields=("/Dest",)) anc[NameObject("/Dest")] = ArrayObject([p, *d[1:]]) outlist.append(self._add_object(anc)) else: d = cast("DictionaryObject", ano["/A"]).get("/D", NullObject()) if d is None or isinstance(d, NullObject): continue if isinstance(d, str): # it is a named dest if str(d) in self.get_named_dest_root(): outlist.append(ano.clone(self).indirect_reference) else: d = cast("ArrayObject", d) p = self._get_cloned_page(d[0], pages, reader) if p is not None: anc = ano.clone(self, ignore_fields=("/D",)) cast("DictionaryObject", anc["/A"])[ NameObject("/D") ] = ArrayObject([p, *d[1:]]) outlist.append(self._add_object(anc)) return outlist def _get_filtered_outline( self, node: Any, pages: dict[int, PageObject], reader: PdfReader, ) -> list[Destination]: """ Extract outline item entries that are part of the specified page set. Args: node: pages: reader: Returns: A list of destination objects. """ new_outline = [] if node is None: node = NullObject() node = node.get_object() if is_null_or_none(node): node = DictionaryObject() if node.get("/Type", "") == "/Outlines" or "/Title" not in node: node = node.get("/First", None) if node is not None: node = node.get_object() new_outline += self._get_filtered_outline(node, pages, reader) else: v: Union[None, IndirectObject, NullObject] while node is not None: node = node.get_object() o = cast("Destination", reader._build_outline_item(node)) v = self._get_cloned_page(cast("PageObject", o["/Page"]), pages, reader) if v is None: v = NullObject() o[NameObject("/Page")] = v if "/First" in node: o._filtered_children = self._get_filtered_outline( node["/First"], pages, reader ) else: o._filtered_children = [] if ( not isinstance(o["/Page"], NullObject) or len(o._filtered_children) > 0 ): new_outline.append(o) node = node.get("/Next", None) return new_outline def _clone_outline(self, dest: Destination) -> TreeObject: n_ol = TreeObject() self._add_object(n_ol) n_ol[NameObject("/Title")] = TextStringObject(dest["/Title"]) if not isinstance(dest["/Page"], NullObject): if dest.node is not None and "/A" in dest.node: n_ol[NameObject("/A")] = dest.node["/A"].clone(self) else: n_ol[NameObject("/Dest")] = dest.dest_array # TODO: /SE if dest.node is not None: n_ol[NameObject("/F")] = NumberObject(dest.node.get("/F", 0)) n_ol[NameObject("/C")] = ArrayObject( dest.node.get( "/C", [FloatObject(0.0), FloatObject(0.0), FloatObject(0.0)] ) ) return n_ol def _insert_filtered_outline( self, outlines: list[Destination], parent: Union[TreeObject, IndirectObject], before: Union[None, TreeObject, IndirectObject] = None, ) -> None: for dest in outlines: # TODO: can be improved to keep A and SE entries (ignored for the moment) # with np=self.add_outline_item_destination(dest,parent,before) if dest.get("/Type", "") == "/Outlines" or "/Title" not in dest: np = parent else: np = self._clone_outline(dest) cast(TreeObject, parent.get_object()).insert_child(np, before, self) self._insert_filtered_outline(dest._filtered_children, np, None) def close(self) -> None: """Implemented for API harmonization.""" return def find_outline_item( self, outline_item: dict[str, Any], root: Optional[OutlineType] = None, ) -> Optional[list[int]]: if root is None: o = self.get_outline_root() else: o = cast("TreeObject", root) i = 0 while o is not None: if ( o.indirect_reference == outline_item or o.get("/Title", None) == outline_item ): return [i] if "/First" in o: res = self.find_outline_item( outline_item, cast(OutlineType, o["/First"]) ) if res: return ([i] if "/Title" in o else []) + res if "/Next" in o: i += 1 o = cast(TreeObject, o["/Next"]) else: return None def reset_translation( self, reader: Union[None, PdfReader, IndirectObject] = None ) -> None: """ Reset the translation table between reader and the writer object. Late cloning will create new independent objects. Args: reader: PdfReader or IndirectObject referencing a PdfReader object. if set to None or omitted, all tables will be reset. """ if reader is None: self._id_translated = {} elif isinstance(reader, PdfReader): try: del self._id_translated[id(reader)] except Exception: pass elif isinstance(reader, IndirectObject): try: del self._id_translated[id(reader.pdf)] except Exception: pass else: raise Exception("invalid parameter {reader}") def set_page_label( self, page_index_from: int, page_index_to: int, style: Optional[PageLabelStyle] = None, prefix: Optional[str] = None, start: Optional[int] = 0, ) -> None: """ Set a page label to a range of pages. Page indexes must be given starting from 0. Labels must have a style, a prefix or both. If a range is not assigned any page label, a decimal label starting from 1 is applied. Args: page_index_from: page index of the beginning of the range starting from 0 page_index_to: page index of the beginning of the range starting from 0 style: The numbering style to be used for the numeric portion of each page label: * ``/D`` Decimal Arabic numerals * ``/R`` Uppercase Roman numerals * ``/r`` Lowercase Roman numerals * ``/A`` Uppercase letters (A to Z for the first 26 pages, AA to ZZ for the next 26, and so on) * ``/a`` Lowercase letters (a to z for the first 26 pages, aa to zz for the next 26, and so on) prefix: The label prefix for page labels in this range. start: The value of the numeric portion for the first page label in the range. Subsequent pages are numbered sequentially from this value, which must be greater than or equal to 1. Default value: 1. """ if style is None and prefix is None: raise ValueError("At least one of style and prefix must be given") if page_index_from < 0: raise ValueError("page_index_from must be greater or equal than 0") if page_index_to < page_index_from: raise ValueError( "page_index_to must be greater or equal than page_index_from" ) if page_index_to >= len(self.pages): raise ValueError("page_index_to exceeds number of pages") if start is not None and start != 0 and start < 1: raise ValueError("If given, start must be greater or equal than one") self._set_page_label(page_index_from, page_index_to, style, prefix, start) def _set_page_label( self, page_index_from: int, page_index_to: int, style: Optional[PageLabelStyle] = None, prefix: Optional[str] = None, start: Optional[int] = 0, ) -> None: """ Set a page label to a range of pages. Page indexes must be given starting from 0. Labels must have a style, a prefix or both. If a range is not assigned any page label a decimal label starting from 1 is applied. Args: page_index_from: page index of the beginning of the range starting from 0 page_index_to: page index of the beginning of the range starting from 0 style: The numbering style to be used for the numeric portion of each page label: /D Decimal Arabic numerals /R Uppercase Roman numerals /r Lowercase Roman numerals /A Uppercase letters (A to Z for the first 26 pages, AA to ZZ for the next 26, and so on) /a Lowercase letters (a to z for the first 26 pages, aa to zz for the next 26, and so on) prefix: The label prefix for page labels in this range. start: The value of the numeric portion for the first page label in the range. Subsequent pages are numbered sequentially from this value, which must be greater than or equal to 1. Default value: 1. """ default_page_label = DictionaryObject() default_page_label[NameObject("/S")] = NameObject("/D") new_page_label = DictionaryObject() if style is not None: new_page_label[NameObject("/S")] = NameObject(style) if prefix is not None: new_page_label[NameObject("/P")] = TextStringObject(prefix) if start != 0: new_page_label[NameObject("/St")] = NumberObject(start) if NameObject(CatalogDictionary.PAGE_LABELS) not in self._root_object: nums = ArrayObject() nums_insert(NumberObject(0), default_page_label, nums) page_labels = TreeObject() page_labels[NameObject("/Nums")] = nums self._root_object[NameObject(CatalogDictionary.PAGE_LABELS)] = page_labels page_labels = cast( TreeObject, self._root_object[NameObject(CatalogDictionary.PAGE_LABELS)] ) nums = cast(ArrayObject, page_labels[NameObject("/Nums")]) nums_insert(NumberObject(page_index_from), new_page_label, nums) nums_clear_range(NumberObject(page_index_from), page_index_to, nums) next_label_pos, *_ = nums_next(NumberObject(page_index_from), nums) if next_label_pos != page_index_to + 1 and page_index_to + 1 < len(self.pages): nums_insert(NumberObject(page_index_to + 1), default_page_label, nums) page_labels[NameObject("/Nums")] = nums self._root_object[NameObject(CatalogDictionary.PAGE_LABELS)] = page_labels def _repr_mimebundle_( self, include: Union[None, Iterable[str]] = None, exclude: Union[None, Iterable[str]] = None, ) -> dict[str, Any]: """ Integration into Jupyter Notebooks. This method returns a dictionary that maps a mime-type to its representation. .. seealso:: https://ipython.readthedocs.io/en/stable/config/integrating.html """ pdf_data = BytesIO() self.write(pdf_data) data = { "application/pdf": pdf_data, } if include is not None: # Filter representations based on include list data = {k: v for k, v in data.items() if k in include} if exclude is not None: # Remove representations based on exclude list data = {k: v for k, v in data.items() if k not in exclude} return data def _pdf_objectify(obj: Union[dict[str, Any], str, float, list[Any]]) -> PdfObject: if isinstance(obj, PdfObject): return obj if isinstance(obj, dict): to_add = DictionaryObject() for key, value in obj.items(): to_add[NameObject(key)] = _pdf_objectify(value) return to_add if isinstance(obj, str): if obj.startswith("/"): return NameObject(obj) return TextStringObject(obj) if isinstance(obj, (float, int)): return FloatObject(obj) if isinstance(obj, list): return ArrayObject(_pdf_objectify(i) for i in obj) raise NotImplementedError( f"{type(obj)=} could not be cast to a PdfObject" ) def _create_outline_item( action_ref: Union[None, IndirectObject], title: str, color: Union[tuple[float, float, float], str, None], italic: bool, bold: bool, ) -> TreeObject: outline_item = TreeObject() if action_ref is not None: outline_item[NameObject("/A")] = action_ref outline_item.update( { NameObject("/Title"): create_string_object(title), } ) if color: if isinstance(color, str): color = hex_to_rgb(color) outline_item.update( {NameObject("/C"): ArrayObject([FloatObject(c) for c in color])} ) if italic or bold: format_flag = 0 if italic: format_flag += OutlineFontFlag.italic if bold: format_flag += OutlineFontFlag.bold outline_item.update({NameObject("/F"): NumberObject(format_flag)}) return outline_item def generate_appearance_stream( txt: str, sel: list[str], da: str, font_full_rev: dict[str, bytes], rct: RectangleObject, font_height: float, y_offset: float, ) -> bytes: ap_stream = f"q\n/Tx BMC \nq\n1 1 {rct.width - 1} {rct.height - 1} re\nW\nBT\n{da}\n".encode() for line_number, line in enumerate(txt.replace("\n", "\r").split("\r")): if line in sel: # may be improved but cannot find how to get fill working => replaced with lined box ap_stream += ( f"1 {y_offset - (line_number * font_height * 1.4) - 1} {rct.width - 2} {font_height + 2} re\n" f"0.5 0.5 0.5 rg s\n{da}\n" ).encode() if line_number == 0: ap_stream += f"2 {y_offset} Td\n".encode() else: # Td is a relative translation ap_stream += f"0 {- font_height * 1.4} Td\n".encode() enc_line: list[bytes] = [ font_full_rev.get(c, c.encode("utf-16-be")) for c in line ] if any(len(c) >= 2 for c in enc_line): ap_stream += b"<" + (b"".join(enc_line)).hex().encode() + b"> Tj\n" else: ap_stream += b"(" + b"".join(enc_line) + b") Tj\n" ap_stream += b"ET\nQ\nEMC\nQ\n" return ap_stream pypdf-6.1.2/pypdf/_xobj_image_helpers.py000066400000000000000000000345561507516550200203460ustar00rootroot00000000000000"""Code in here is only used by pypdf.filters._xobj_to_image""" import sys from io import BytesIO from typing import Any, Literal, Union, cast from ._utils import check_if_whitespace_only, logger_warning from .constants import ColorSpaces from .constants import FilterTypes as FT from .constants import ImageAttributes as IA from .errors import EmptyImageDataError, PdfReadError from .generic import ( ArrayObject, DecodedStreamObject, EncodedStreamObject, NullObject, TextStringObject, is_null_or_none, ) if sys.version_info[:2] >= (3, 10): from typing import TypeAlias else: from typing_extensions import TypeAlias try: from PIL import Image, UnidentifiedImageError # noqa: F401 except ImportError: raise ImportError( "pillow is required to do image extraction. " "It can be installed via 'pip install pypdf[image]'" ) mode_str_type: TypeAlias = Literal[ "", "1", "RGB", "2bits", "4bits", "P", "L", "RGBA", "CMYK" ] MAX_IMAGE_MODE_NESTING_DEPTH: int = 10 def _get_imagemode( color_space: Union[str, list[Any], Any], color_components: int, prev_mode: mode_str_type, depth: int = 0, ) -> tuple[mode_str_type, bool]: """ Returns: Image mode, not taking into account mask (transparency). ColorInversion is required (like for some DeviceCMYK). """ if depth > MAX_IMAGE_MODE_NESTING_DEPTH: raise PdfReadError( "Color spaces nested too deeply. If required, consider increasing MAX_IMAGE_MODE_NESTING_DEPTH." ) if is_null_or_none(color_space): return "", False color_space_str: str = "" if isinstance(color_space, str): color_space_str = color_space elif not isinstance(color_space, list): raise PdfReadError( "Cannot interpret color space", color_space ) # pragma: no cover elif color_space[0].startswith("/Cal"): # /CalRGB and /CalGray color_space_str = "/Device" + color_space[0][4:] elif color_space[0] == "/ICCBased": icc_profile = color_space[1].get_object() color_components = cast(int, icc_profile["/N"]) color_space_str = icc_profile.get("/Alternate", "") elif color_space[0] == "/Indexed": color_space_str = color_space[1].get_object() mode, invert_color = _get_imagemode( color_space_str, color_components, prev_mode, depth + 1 ) if mode in ("RGB", "CMYK"): mode = "P" return mode, invert_color elif color_space[0] == "/Separation": color_space_str = color_space[2].get_object() mode, invert_color = _get_imagemode( color_space_str, color_components, prev_mode, depth + 1 ) return mode, True elif color_space[0] == "/DeviceN": original_color_space = color_space color_components = len(color_space[1]) color_space_str = color_space[2].get_object() if color_space_str == "/DeviceCMYK" and color_components == 1: if original_color_space[1][0] != "/Black": logger_warning( f"Color {original_color_space[1][0]} converted to Gray. Please share PDF with pypdf dev team", __name__, ) return "L", True mode, invert_color = _get_imagemode( color_space_str, color_components, prev_mode, depth + 1 ) return mode, invert_color mode_map: dict[str, mode_str_type] = { "1bit": "1", # must be zeroth position: color_components may index the values "/DeviceGray": "L", # must be first position: color_components may index the values "palette": "P", # must be second position: color_components may index the values "/DeviceRGB": "RGB", # must be third position: color_components may index the values "/DeviceCMYK": "CMYK", # must be fourth position: color_components may index the values "2bit": "2bits", "4bit": "4bits", } mode = ( mode_map.get(color_space_str) or list(mode_map.values())[color_components] or prev_mode ) return mode, mode == "CMYK" def bits2byte(data: bytes, size: tuple[int, int], bits: int) -> bytes: mask = (1 << bits) - 1 byte_buffer = bytearray(size[0] * size[1]) data_index = 0 bit = 8 - bits for y in range(size[1]): if bit != 8 - bits: data_index += 1 bit = 8 - bits for x in range(size[0]): byte_buffer[x + y * size[0]] = (data[data_index] >> bit) & mask bit -= bits if bit < 0: data_index += 1 bit = 8 - bits return bytes(byte_buffer) def _extended_image_frombytes( mode: str, size: tuple[int, int], data: bytes ) -> Image.Image: try: img = Image.frombytes(mode, size, data) except ValueError as exc: nb_pix = size[0] * size[1] data_length = len(data) if data_length == 0: raise EmptyImageDataError( "Data is 0 bytes, cannot process an image from empty data." ) from exc if data_length % nb_pix != 0: raise exc k = nb_pix * len(mode) / data_length data = b"".join(bytes((x,) * int(k)) for x in data) img = Image.frombytes(mode, size, data) return img def __handle_flate__indexed(color_space: ArrayObject) -> tuple[Any, Any, Any, Any]: count = len(color_space) if count == 4: color_space, base, hival, lookup = (value.get_object() for value in color_space) return color_space, base, hival, lookup # Deal with strange AutoDesk files where `base` and `hival` look like this: # /DeviceRGB\x00255 element1 = color_space[1] element1 = element1 if isinstance(element1, str) else element1.get_object() if count == 3 and "\x00" in element1: color_space, lookup = color_space[0].get_object(), color_space[2].get_object() base, hival = element1.split("\x00") hival = int(hival) return color_space, base, hival, lookup raise PdfReadError(f"Expected color space with 4 values, got {count}: {color_space}") def _handle_flate( size: tuple[int, int], data: bytes, mode: mode_str_type, color_space: str, colors: int, obj_as_text: str, ) -> tuple[Image.Image, str, str, bool]: """ Process image encoded in flateEncode Returns img, image_format, extension, color inversion """ extension = ".png" # mime_type = "image/png" image_format = "PNG" lookup: Any base: Any hival: Any if isinstance(color_space, ArrayObject) and color_space[0] == "/Indexed": color_space, base, hival, lookup = __handle_flate__indexed(color_space) if mode == "2bits": mode = "P" data = bits2byte(data, size, 2) elif mode == "4bits": mode = "P" data = bits2byte(data, size, 4) img = _extended_image_frombytes(mode, size, data) if color_space == "/Indexed": if isinstance(lookup, (EncodedStreamObject, DecodedStreamObject)): lookup = lookup.get_data() if isinstance(lookup, TextStringObject): lookup = lookup.original_bytes if isinstance(lookup, str): lookup = lookup.encode() try: nb, conv, mode = { # type: ignore "1": (0, "", ""), "L": (1, "P", "L"), "P": (0, "", ""), "RGB": (3, "P", "RGB"), "CMYK": (4, "P", "CMYK"), }[_get_imagemode(base, 0, "")[0]] except KeyError: # pragma: no cover logger_warning( f"Base {base} not coded please share the pdf file with pypdf dev team", __name__, ) lookup = None else: if img.mode == "1": # Two values ("high" and "low"). expected_count = 2 * nb actual_count = len(lookup) if actual_count != expected_count: if actual_count < expected_count: logger_warning( f"Not enough lookup values: Expected {expected_count}, got {actual_count}.", __name__ ) lookup += bytes([0] * (expected_count - actual_count)) elif not check_if_whitespace_only(lookup[expected_count:]): logger_warning( f"Too many lookup values: Expected {expected_count}, got {actual_count}.", __name__ ) lookup = lookup[:expected_count] colors_arr = [lookup[:nb], lookup[nb:]] arr = b"".join( b"".join( colors_arr[1 if img.getpixel((x, y)) > 127 else 0] for x in range(img.size[0]) ) for y in range(img.size[1]) ) img = Image.frombytes(mode, img.size, arr) else: img = img.convert(conv) if len(lookup) != (hival + 1) * nb: logger_warning(f"Invalid Lookup Table in {obj_as_text}", __name__) lookup = None elif mode == "L": # gray lookup does not work : it is converted to a similar RGB lookup lookup = b"".join([bytes([b, b, b]) for b in lookup]) mode = "RGB" # TODO : cf https://github.com/py-pdf/pypdf/pull/2039 # this is a work around until PIL is able to process CMYK images elif mode == "CMYK": _rgb = [] for _c, _m, _y, _k in ( lookup[n : n + 4] for n in range(0, 4 * (len(lookup) // 4), 4) ): _r = int(255 * (1 - _c / 255) * (1 - _k / 255)) _g = int(255 * (1 - _m / 255) * (1 - _k / 255)) _b = int(255 * (1 - _y / 255) * (1 - _k / 255)) _rgb.append(bytes((_r, _g, _b))) lookup = b"".join(_rgb) mode = "RGB" if lookup is not None: img.putpalette(lookup, rawmode=mode) img = img.convert("L" if base == ColorSpaces.DEVICE_GRAY else "RGB") elif not isinstance(color_space, NullObject) and color_space[0] == "/ICCBased": # see Table 66 - Additional Entries Specific to an ICC Profile # Stream Dictionary mode2 = _get_imagemode(color_space, colors, mode)[0] if mode != mode2: img = Image.frombytes(mode2, size, data) # reloaded as mode may have changed if mode == "CMYK": extension = ".tif" image_format = "TIFF" return img, image_format, extension, False def _handle_jpx( size: tuple[int, int], data: bytes, mode: mode_str_type, color_space: str, colors: int, ) -> tuple[Image.Image, str, str, bool]: """ Process image encoded in flateEncode Returns img, image_format, extension, inversion """ extension = ".jp2" # mime_type = "image/x-jp2" img1 = Image.open(BytesIO(data), formats=("JPEG2000",)) mode, invert_color = _get_imagemode(color_space, colors, mode) if mode == "": mode = cast(mode_str_type, img1.mode) invert_color = mode in ("CMYK",) if img1.mode == "RGBA" and mode == "RGB": mode = "RGBA" # we need to convert to the good mode if img1.mode == mode or {img1.mode, mode} == {"L", "P"}: # compare (unordered) sets # L and P are indexed modes which should not be changed. img = img1 elif {img1.mode, mode} == {"RGBA", "CMYK"}: # RGBA / CMYK are 4bytes encoding where # the encoding should be corrected img = Image.frombytes(mode, img1.size, img1.tobytes()) else: # pragma: no cover img = img1.convert(mode) # for CMYK conversion : # https://stcom/questions/38855022/conversion-from-cmyk-to-rgb-with-pillow-is-different-from-that-of-photoshop # not implemented for the moment as I need to get properly the ICC if img.mode == "CMYK": img = img.convert("RGB") image_format = "JPEG2000" return img, image_format, extension, invert_color def _apply_decode( img: Image.Image, x_object_obj: dict[str, Any], lfilters: FT, color_space: Union[str, list[Any], Any], invert_color: bool, ) -> Image.Image: # CMYK image and other color spaces without decode # requires reverting scale (cf p243,2§ last sentence) decode = x_object_obj.get( IA.DECODE, ([1.0, 0.0] * len(img.getbands())) if ( (img.mode == "CMYK" and lfilters in (FT.DCT_DECODE, FT.JPX_DECODE)) or (invert_color and img.mode == "L") ) else None, ) if ( isinstance(color_space, ArrayObject) and color_space[0].get_object() == "/Indexed" ): decode = None # decode is meaningless if Indexed if ( isinstance(color_space, ArrayObject) and color_space[0].get_object() == "/Separation" ): decode = [1.0, 0.0] * len(img.getbands()) if decode is not None and not all(decode[i] == i % 2 for i in range(len(decode))): lut: list[int] = [] for i in range(0, len(decode), 2): dmin = decode[i] dmax = decode[i + 1] lut.extend( round(255.0 * (j / 255.0 * (dmax - dmin) + dmin)) for j in range(256) ) img = img.point(lut) return img def _get_mode_and_invert_color( x_object_obj: dict[str, Any], colors: int, color_space: Union[str, list[Any], Any] ) -> tuple[mode_str_type, bool]: if ( IA.COLOR_SPACE in x_object_obj and x_object_obj[IA.COLOR_SPACE] == ColorSpaces.DEVICE_RGB ): # https://pillow.readthedocs.io/en/stable/handbook/concepts.html#modes mode: mode_str_type = "RGB" if x_object_obj.get("/BitsPerComponent", 8) < 8: mode, invert_color = _get_imagemode( f"{x_object_obj.get('/BitsPerComponent', 8)}bit", 0, "" ) else: mode, invert_color = _get_imagemode( color_space, 2 if ( colors == 1 and ( not is_null_or_none(color_space) and "Gray" not in color_space ) ) else colors, "", ) return mode, invert_color pypdf-6.1.2/pypdf/annotations/000077500000000000000000000000001507516550200163275ustar00rootroot00000000000000pypdf-6.1.2/pypdf/annotations/__init__.py000066400000000000000000000017361507516550200204470ustar00rootroot00000000000000""" PDF specifies several annotation types which pypdf makes available here. The names of the annotations and their attributes do not reflect the names in the specification in all cases. For example, the PDF standard defines a 'Square' annotation that does not actually need to be square. For this reason, pypdf calls it 'Rectangle'. At their core, all annotation types are DictionaryObjects. That means if pypdf does not implement a feature, users can easily extend the given functionality. """ from ._base import NO_FLAGS, AnnotationDictionary from ._markup_annotations import ( Ellipse, FreeText, Highlight, Line, MarkupAnnotation, Polygon, PolyLine, Rectangle, Text, ) from ._non_markup_annotations import Link, Popup __all__ = [ "NO_FLAGS", "AnnotationDictionary", "Ellipse", "FreeText", "Highlight", "Line", "Link", "MarkupAnnotation", "PolyLine", "Polygon", "Popup", "Rectangle", "Text", ] pypdf-6.1.2/pypdf/annotations/_base.py000066400000000000000000000017011507516550200177510ustar00rootroot00000000000000from abc import ABC from ..constants import AnnotationFlag from ..generic import NameObject, NumberObject from ..generic._data_structures import DictionaryObject class AnnotationDictionary(DictionaryObject, ABC): def __init__(self) -> None: super().__init__() from ..generic._base import NameObject # noqa: PLC0415 # /Rect should not be added here as Polygon and PolyLine can automatically set it self[NameObject("/Type")] = NameObject("/Annot") # The flags were NOT added to the constructor on purpose: # We expect that most users don't want to change the default. # If they do, they can use the property. The default is 0. @property def flags(self) -> AnnotationFlag: return self.get(NameObject("/F"), AnnotationFlag(0)) @flags.setter def flags(self, value: AnnotationFlag) -> None: self[NameObject("/F")] = NumberObject(value) NO_FLAGS = AnnotationFlag(0) pypdf-6.1.2/pypdf/annotations/_markup_annotations.py000066400000000000000000000225651507516550200227660ustar00rootroot00000000000000import sys from abc import ABC from typing import Any, Optional, Union from ..constants import AnnotationFlag from ..generic import ArrayObject, DictionaryObject from ..generic._base import ( BooleanObject, FloatObject, NameObject, NumberObject, TextStringObject, ) from ..generic._rectangle import RectangleObject from ..generic._utils import hex_to_rgb from ._base import NO_FLAGS, AnnotationDictionary if sys.version_info[:2] >= (3, 10): from typing import TypeAlias else: # PEP 613 introduced typing.TypeAlias with Python 3.10 # For older Python versions, the backport typing_extensions is necessary: from typing_extensions import TypeAlias Vertex: TypeAlias = tuple[float, float] def _get_bounding_rectangle(vertices: list[Vertex]) -> RectangleObject: x_min, y_min = vertices[0][0], vertices[0][1] x_max, y_max = vertices[0][0], vertices[0][1] for x, y in vertices: x_min = min(x_min, x) y_min = min(y_min, y) x_max = max(x_max, x) y_max = max(y_max, y) return RectangleObject((x_min, y_min, x_max, y_max)) class MarkupAnnotation(AnnotationDictionary, ABC): """ Base class for all markup annotations. Args: title_bar: Text to be displayed in the title bar of the annotation; by convention this is the name of the author """ def __init__(self, *, title_bar: Optional[str] = None) -> None: if title_bar is not None: self[NameObject("/T")] = TextStringObject(title_bar) class Text(MarkupAnnotation): """ A text annotation. Args: rect: array of four integers ``[xLL, yLL, xUR, yUR]`` specifying the clickable rectangular area text: The text that is added to the document open: flags: """ def __init__( self, *, rect: Union[RectangleObject, tuple[float, float, float, float]], text: str, open: bool = False, flags: int = NO_FLAGS, **kwargs: Any, ) -> None: super().__init__(**kwargs) self[NameObject("/Subtype")] = NameObject("/Text") self[NameObject("/Rect")] = RectangleObject(rect) self[NameObject("/Contents")] = TextStringObject(text) self[NameObject("/Open")] = BooleanObject(open) self[NameObject("/Flags")] = NumberObject(flags) class FreeText(MarkupAnnotation): """A FreeText annotation""" def __init__( self, *, text: str, rect: Union[RectangleObject, tuple[float, float, float, float]], font: str = "Helvetica", bold: bool = False, italic: bool = False, font_size: str = "14pt", font_color: str = "000000", border_color: Optional[str] = "000000", background_color: Optional[str] = "ffffff", **kwargs: Any, ) -> None: super().__init__(**kwargs) self[NameObject("/Subtype")] = NameObject("/FreeText") self[NameObject("/Rect")] = RectangleObject(rect) # Table 225 of the 1.7 reference ("CSS2 style attributes used in rich text strings") font_str = "font: " if italic: font_str = f"{font_str}italic " else: font_str = f"{font_str}normal " if bold: font_str = f"{font_str}bold " else: font_str = f"{font_str}normal " font_str = f"{font_str}{font_size} {font}" font_str = f"{font_str};text-align:left;color:#{font_color}" default_appearance_string = "" if border_color: for st in hex_to_rgb(border_color): default_appearance_string = f"{default_appearance_string}{st} " default_appearance_string = f"{default_appearance_string}rg" self.update( { NameObject("/Subtype"): NameObject("/FreeText"), NameObject("/Rect"): RectangleObject(rect), NameObject("/Contents"): TextStringObject(text), # font size color NameObject("/DS"): TextStringObject(font_str), NameObject("/DA"): TextStringObject(default_appearance_string), } ) if border_color is None: # Border Style self[NameObject("/BS")] = DictionaryObject( { # width of 0 means no border NameObject("/W"): NumberObject(0) } ) if background_color is not None: self[NameObject("/C")] = ArrayObject( [FloatObject(n) for n in hex_to_rgb(background_color)] ) class Line(MarkupAnnotation): def __init__( self, p1: Vertex, p2: Vertex, rect: Union[RectangleObject, tuple[float, float, float, float]], text: str = "", **kwargs: Any, ) -> None: super().__init__(**kwargs) self.update( { NameObject("/Subtype"): NameObject("/Line"), NameObject("/Rect"): RectangleObject(rect), NameObject("/L"): ArrayObject( [ FloatObject(p1[0]), FloatObject(p1[1]), FloatObject(p2[0]), FloatObject(p2[1]), ] ), NameObject("/LE"): ArrayObject( [ NameObject("/None"), NameObject("/None"), ] ), NameObject("/IC"): ArrayObject( [ FloatObject(0.5), FloatObject(0.5), FloatObject(0.5), ] ), NameObject("/Contents"): TextStringObject(text), } ) class PolyLine(MarkupAnnotation): def __init__( self, vertices: list[Vertex], **kwargs: Any, ) -> None: super().__init__(**kwargs) if len(vertices) == 0: raise ValueError("A polygon needs at least 1 vertex with two coordinates") coord_list = [] for x, y in vertices: coord_list.append(NumberObject(x)) coord_list.append(NumberObject(y)) self.update( { NameObject("/Subtype"): NameObject("/PolyLine"), NameObject("/Vertices"): ArrayObject(coord_list), NameObject("/Rect"): RectangleObject(_get_bounding_rectangle(vertices)), } ) class Rectangle(MarkupAnnotation): def __init__( self, rect: Union[RectangleObject, tuple[float, float, float, float]], *, interior_color: Optional[str] = None, **kwargs: Any, ) -> None: super().__init__(**kwargs) self.update( { NameObject("/Type"): NameObject("/Annot"), NameObject("/Subtype"): NameObject("/Square"), NameObject("/Rect"): RectangleObject(rect), } ) if interior_color: self[NameObject("/IC")] = ArrayObject( [FloatObject(n) for n in hex_to_rgb(interior_color)] ) class Highlight(MarkupAnnotation): def __init__( self, *, rect: Union[RectangleObject, tuple[float, float, float, float]], quad_points: ArrayObject, highlight_color: str = "ff0000", printing: bool = False, **kwargs: Any, ) -> None: super().__init__(**kwargs) self.update( { NameObject("/Subtype"): NameObject("/Highlight"), NameObject("/Rect"): RectangleObject(rect), NameObject("/QuadPoints"): quad_points, NameObject("/C"): ArrayObject( [FloatObject(n) for n in hex_to_rgb(highlight_color)] ), } ) if printing: self.flags = AnnotationFlag.PRINT class Ellipse(MarkupAnnotation): def __init__( self, rect: Union[RectangleObject, tuple[float, float, float, float]], *, interior_color: Optional[str] = None, **kwargs: Any, ) -> None: super().__init__(**kwargs) self.update( { NameObject("/Type"): NameObject("/Annot"), NameObject("/Subtype"): NameObject("/Circle"), NameObject("/Rect"): RectangleObject(rect), } ) if interior_color: self[NameObject("/IC")] = ArrayObject( [FloatObject(n) for n in hex_to_rgb(interior_color)] ) class Polygon(MarkupAnnotation): def __init__( self, vertices: list[tuple[float, float]], **kwargs: Any, ) -> None: super().__init__(**kwargs) if len(vertices) == 0: raise ValueError("A polygon needs at least 1 vertex with two coordinates") coord_list = [] for x, y in vertices: coord_list.append(NumberObject(x)) coord_list.append(NumberObject(y)) self.update( { NameObject("/Type"): NameObject("/Annot"), NameObject("/Subtype"): NameObject("/Polygon"), NameObject("/Vertices"): ArrayObject(coord_list), NameObject("/IT"): NameObject("/PolygonCloud"), NameObject("/Rect"): RectangleObject(_get_bounding_rectangle(vertices)), } ) pypdf-6.1.2/pypdf/annotations/_non_markup_annotations.py000066400000000000000000000071011507516550200236250ustar00rootroot00000000000000from typing import TYPE_CHECKING, Any, Optional, Union from ..generic._base import ( BooleanObject, NameObject, NumberObject, TextStringObject, ) from ..generic._data_structures import ArrayObject, DictionaryObject from ..generic._fit import DEFAULT_FIT, Fit from ..generic._rectangle import RectangleObject from ._base import AnnotationDictionary class Link(AnnotationDictionary): def __init__( self, *, rect: Union[RectangleObject, tuple[float, float, float, float]], border: Optional[ArrayObject] = None, url: Optional[str] = None, target_page_index: Optional[int] = None, fit: Fit = DEFAULT_FIT, **kwargs: Any, ) -> None: super().__init__(**kwargs) if TYPE_CHECKING: from ..types import BorderArrayType # noqa: PLC0415 is_external = url is not None is_internal = target_page_index is not None if not is_external and not is_internal: raise ValueError( "Either 'url' or 'target_page_index' have to be provided. Both were None." ) if is_external and is_internal: raise ValueError( "Either 'url' or 'target_page_index' have to be provided. " f"{url=}, {target_page_index=}" ) border_arr: BorderArrayType if border is not None: border_arr = [NumberObject(n) for n in border[:3]] if len(border) == 4: dash_pattern = ArrayObject([NumberObject(n) for n in border[3]]) border_arr.append(dash_pattern) else: border_arr = [NumberObject(0)] * 3 self.update( { NameObject("/Type"): NameObject("/Annot"), NameObject("/Subtype"): NameObject("/Link"), NameObject("/Rect"): RectangleObject(rect), NameObject("/Border"): ArrayObject(border_arr), } ) if is_external: self[NameObject("/A")] = DictionaryObject( { NameObject("/S"): NameObject("/URI"), NameObject("/Type"): NameObject("/Action"), NameObject("/URI"): TextStringObject(url), } ) if is_internal: # This needs to be updated later! dest_deferred = DictionaryObject( { "target_page_index": NumberObject(target_page_index), "fit": NameObject(fit.fit_type), "fit_args": fit.fit_args, } ) self[NameObject("/Dest")] = dest_deferred class Popup(AnnotationDictionary): def __init__( self, *, rect: Union[RectangleObject, tuple[float, float, float, float]], parent: Optional[DictionaryObject] = None, open: bool = False, **kwargs: Any, ) -> None: super().__init__(**kwargs) self.update( { NameObject("/Subtype"): NameObject("/Popup"), NameObject("/Rect"): RectangleObject(rect), NameObject("/Open"): BooleanObject(open), } ) if parent: # This needs to be an indirect object try: self[NameObject("/Parent")] = parent.indirect_reference except AttributeError: from .._utils import logger_warning # noqa: PLC0415 logger_warning( "Unregistered Parent object : No Parent field set", __name__, ) pypdf-6.1.2/pypdf/constants.py000066400000000000000000000547521507516550200163750ustar00rootroot00000000000000"""Various constants, enums, and flags to aid readability.""" from enum import Enum, IntFlag, auto, unique class StrEnum(str, Enum): # Once we are on Python 3.11+: enum.StrEnum def __str__(self) -> str: return str(self.value) class Core: """Keywords that don't quite belong anywhere else.""" OUTLINES = "/Outlines" THREADS = "/Threads" PAGE = "/Page" PAGES = "/Pages" CATALOG = "/Catalog" class TrailerKeys: SIZE = "/Size" PREV = "/Prev" ROOT = "/Root" ENCRYPT = "/Encrypt" INFO = "/Info" ID = "/ID" class CatalogAttributes: NAMES = "/Names" DESTS = "/Dests" class EncryptionDictAttributes: """ Additional encryption dictionary entries for the standard security handler. Table 3.19, Page 122. Table 21 of the 2.0 manual. """ R = "/R" # number, required; revision of the standard security handler O = "/O" # 32-byte string, required # noqa: E741 U = "/U" # 32-byte string, required P = "/P" # integer flag, required; permitted operations ENCRYPT_METADATA = "/EncryptMetadata" # boolean flag, optional class UserAccessPermissions(IntFlag): """ Table 3.20 User access permissions. Table 22 of the 2.0 manual. """ R1 = 1 R2 = 2 PRINT = 4 MODIFY = 8 EXTRACT = 16 ADD_OR_MODIFY = 32 R7 = 64 R8 = 128 FILL_FORM_FIELDS = 256 EXTRACT_TEXT_AND_GRAPHICS = 512 ASSEMBLE_DOC = 1024 PRINT_TO_REPRESENTATION = 2048 R13 = 2**12 R14 = 2**13 R15 = 2**14 R16 = 2**15 R17 = 2**16 R18 = 2**17 R19 = 2**18 R20 = 2**19 R21 = 2**20 R22 = 2**21 R23 = 2**22 R24 = 2**23 R25 = 2**24 R26 = 2**25 R27 = 2**26 R28 = 2**27 R29 = 2**28 R30 = 2**29 R31 = 2**30 R32 = 2**31 @classmethod def _is_reserved(cls, name: str) -> bool: """Check if the given name corresponds to a reserved flag entry.""" return name.startswith("R") and name[1:].isdigit() @classmethod def _is_active(cls, name: str) -> bool: """Check if the given reserved name defaults to 1 = active.""" return name not in {"R1", "R2"} def to_dict(self) -> dict[str, bool]: """Convert the given flag value to a corresponding verbose name mapping.""" result: dict[str, bool] = {} for name, flag in UserAccessPermissions.__members__.items(): if UserAccessPermissions._is_reserved(name): continue result[name.lower()] = (self & flag) == flag return result @classmethod def from_dict(cls, value: dict[str, bool]) -> "UserAccessPermissions": """Convert the verbose name mapping to the corresponding flag value.""" value_copy = value.copy() result = cls(0) for name, flag in cls.__members__.items(): if cls._is_reserved(name): # Reserved names have a required value. Use it. if cls._is_active(name): result |= flag continue is_active = value_copy.pop(name.lower(), False) if is_active: result |= flag if value_copy: raise ValueError(f"Unknown dictionary keys: {value_copy!r}") return result @classmethod def all(cls) -> "UserAccessPermissions": return cls((2**32 - 1) - cls.R1 - cls.R2) class Resources: """ Table 3.30 Entries in a resource dictionary. Table 34 in the 2.0 reference. """ EXT_G_STATE = "/ExtGState" # dictionary, optional COLOR_SPACE = "/ColorSpace" # dictionary, optional PATTERN = "/Pattern" # dictionary, optional SHADING = "/Shading" # dictionary, optional XOBJECT = "/XObject" # dictionary, optional FONT = "/Font" # dictionary, optional PROC_SET = "/ProcSet" # array, optional PROPERTIES = "/Properties" # dictionary, optional class PagesAttributes: """§7.7.3.2 of the 1.7 and 2.0 reference.""" TYPE = "/Type" # name, required; must be /Pages PARENT = "/Parent" # dictionary, required; indirect reference to pages object KIDS = "/Kids" # array, required; List of indirect references COUNT = "/Count" # integer, required; the number of leaf nodes (page objects) # that are descendants of this node within the page tree class PageAttributes: """§7.7.3.3 of the 1.7 and 2.0 reference.""" TYPE = "/Type" # name, required; must be /Page PARENT = "/Parent" # dictionary, required; a pages object LAST_MODIFIED = ( "/LastModified" # date, optional; date and time of last modification ) RESOURCES = "/Resources" # dictionary, required if there are any MEDIABOX = "/MediaBox" # rectangle, required; rectangle specifying page size CROPBOX = "/CropBox" # rectangle, optional BLEEDBOX = "/BleedBox" # rectangle, optional TRIMBOX = "/TrimBox" # rectangle, optional ARTBOX = "/ArtBox" # rectangle, optional BOX_COLOR_INFO = "/BoxColorInfo" # dictionary, optional CONTENTS = "/Contents" # stream or array, optional ROTATE = "/Rotate" # integer, optional; page rotation in degrees GROUP = "/Group" # dictionary, optional; page group THUMB = "/Thumb" # stream, optional; indirect reference to image of the page B = "/B" # array, optional DUR = "/Dur" # number, optional TRANS = "/Trans" # dictionary, optional ANNOTS = "/Annots" # array, optional; an array of annotations AA = "/AA" # dictionary, optional METADATA = "/Metadata" # stream, optional PIECE_INFO = "/PieceInfo" # dictionary, optional STRUCT_PARENTS = "/StructParents" # integer, optional ID = "/ID" # byte string, optional PZ = "/PZ" # number, optional SEPARATION_INFO = "/SeparationInfo" # dictionary, optional TABS = "/Tabs" # name, optional TEMPLATE_INSTANTIATED = "/TemplateInstantiated" # name, optional PRES_STEPS = "/PresSteps" # dictionary, optional USER_UNIT = "/UserUnit" # number, optional VP = "/VP" # dictionary, optional AF = "/AF" # array of dictionaries, optional OUTPUT_INTENTS = "/OutputIntents" # array, optional D_PART = "/DPart" # dictionary, required, if this page is within the range of a DPart, not permitted otherwise class FileSpecificationDictionaryEntries: """Table 3.41 Entries in a file specification dictionary.""" Type = "/Type" FS = "/FS" # The name of the file system to be used to interpret this file specification F = "/F" # A file specification string of the form described in §3.10.1 UF = "/UF" # A Unicode string of the file as described in §3.10.1 DOS = "/DOS" Mac = "/Mac" Unix = "/Unix" ID = "/ID" V = "/V" EF = "/EF" # dictionary, containing a subset of the keys F, UF, DOS, Mac, and Unix RF = "/RF" # dictionary, containing arrays of /EmbeddedFile DESC = "/Desc" # description of the file Cl = "/Cl" class StreamAttributes: """ Table 4.2. Table 5 in the 2.0 reference. """ LENGTH = "/Length" # integer, required FILTER = "/Filter" # name or array of names, optional DECODE_PARMS = "/DecodeParms" # variable, optional -- 'decodeParams is wrong @unique class FilterTypes(StrEnum): """§7.4 of the 1.7 and 2.0 references.""" ASCII_HEX_DECODE = "/ASCIIHexDecode" # abbreviation: AHx ASCII_85_DECODE = "/ASCII85Decode" # abbreviation: A85 LZW_DECODE = "/LZWDecode" # abbreviation: LZW FLATE_DECODE = "/FlateDecode" # abbreviation: Fl RUN_LENGTH_DECODE = "/RunLengthDecode" # abbreviation: RL CCITT_FAX_DECODE = "/CCITTFaxDecode" # abbreviation: CCF DCT_DECODE = "/DCTDecode" # abbreviation: DCT JPX_DECODE = "/JPXDecode" JBIG2_DECODE = "/JBIG2Decode" class FilterTypeAbbreviations: """§8.9.7 of the 1.7 and 2.0 references.""" AHx = "/AHx" A85 = "/A85" LZW = "/LZW" FL = "/Fl" RL = "/RL" CCF = "/CCF" DCT = "/DCT" class LzwFilterParameters: """ Table 4.4. Table 8 in the 2.0 reference. """ PREDICTOR = "/Predictor" # integer COLORS = "/Colors" # integer BITS_PER_COMPONENT = "/BitsPerComponent" # integer COLUMNS = "/Columns" # integer EARLY_CHANGE = "/EarlyChange" # integer class CcittFaxDecodeParameters: """ Table 4.5. Table 11 in the 2.0 reference. """ K = "/K" # integer END_OF_LINE = "/EndOfLine" # boolean ENCODED_BYTE_ALIGN = "/EncodedByteAlign" # boolean COLUMNS = "/Columns" # integer ROWS = "/Rows" # integer END_OF_BLOCK = "/EndOfBlock" # boolean BLACK_IS_1 = "/BlackIs1" # boolean DAMAGED_ROWS_BEFORE_ERROR = "/DamagedRowsBeforeError" # integer class ImageAttributes: """§11.6.5 of the 1.7 and 2.0 references.""" TYPE = "/Type" # name, required; must be /XObject SUBTYPE = "/Subtype" # name, required; must be /Image NAME = "/Name" # name, required WIDTH = "/Width" # integer, required HEIGHT = "/Height" # integer, required BITS_PER_COMPONENT = "/BitsPerComponent" # integer, required COLOR_SPACE = "/ColorSpace" # name, required DECODE = "/Decode" # array, optional INTENT = "/Intent" # string, optional INTERPOLATE = "/Interpolate" # boolean, optional IMAGE_MASK = "/ImageMask" # boolean, optional MASK = "/Mask" # 1-bit image mask stream S_MASK = "/SMask" # dictionary or name, optional class ColorSpaces: DEVICE_RGB = "/DeviceRGB" DEVICE_CMYK = "/DeviceCMYK" DEVICE_GRAY = "/DeviceGray" class TypArguments: """Table 8.2 of the PDF 1.7 reference.""" LEFT = "/Left" RIGHT = "/Right" BOTTOM = "/Bottom" TOP = "/Top" class TypFitArguments: """Table 8.2 of the PDF 1.7 reference.""" XYZ = "/XYZ" FIT = "/Fit" FIT_H = "/FitH" FIT_V = "/FitV" FIT_R = "/FitR" FIT_B = "/FitB" FIT_BH = "/FitBH" FIT_BV = "/FitBV" class GoToActionArguments: S = "/S" # name, required: type of action D = "/D" # name, byte string, or array, required: destination to jump to SD = "/SD" # array, optional: structure destination to jump to class AnnotationDictionaryAttributes: """Table 8.15 Entries common to all annotation dictionaries.""" Type = "/Type" Subtype = "/Subtype" Rect = "/Rect" Contents = "/Contents" P = "/P" NM = "/NM" M = "/M" F = "/F" AP = "/AP" AS = "/AS" DA = "/DA" Border = "/Border" C = "/C" StructParent = "/StructParent" OC = "/OC" class InteractiveFormDictEntries: Fields = "/Fields" NeedAppearances = "/NeedAppearances" SigFlags = "/SigFlags" CO = "/CO" DR = "/DR" DA = "/DA" Q = "/Q" XFA = "/XFA" class FieldDictionaryAttributes: """ Entries common to all field dictionaries (Table 8.69 PDF 1.7 reference) (*very partially documented here*). FFBits provides the constants used for `/Ff` from Table 8.70/8.75/8.77/8.79 """ FT = "/FT" # name, required for terminal fields Parent = "/Parent" # dictionary, required for children Kids = "/Kids" # array, sometimes required T = "/T" # text string, optional TU = "/TU" # text string, optional TM = "/TM" # text string, optional Ff = "/Ff" # integer, optional V = "/V" # text string or array, optional DV = "/DV" # text string, optional AA = "/AA" # dictionary, optional Opt = "/Opt" # array, optional class FfBits(IntFlag): """ Ease building /Ff flags Some entries may be specific to: * Text (Tx) (Table 8.75 PDF 1.7 reference) * Buttons (Btn) (Table 8.77 PDF 1.7 reference) * Choice (Ch) (Table 8.79 PDF 1.7 reference) """ ReadOnly = 1 << 0 """common to Tx/Btn/Ch in Table 8.70""" Required = 1 << 1 """common to Tx/Btn/Ch in Table 8.70""" NoExport = 1 << 2 """common to Tx/Btn/Ch in Table 8.70""" Multiline = 1 << 12 """Tx""" Password = 1 << 13 """Tx""" NoToggleToOff = 1 << 14 """Btn""" Radio = 1 << 15 """Btn""" Pushbutton = 1 << 16 """Btn""" Combo = 1 << 17 """Ch""" Edit = 1 << 18 """Ch""" Sort = 1 << 19 """Ch""" FileSelect = 1 << 20 """Tx""" MultiSelect = 1 << 21 """Tx""" DoNotSpellCheck = 1 << 22 """Tx/Ch""" DoNotScroll = 1 << 23 """Tx""" Comb = 1 << 24 """Tx""" RadiosInUnison = 1 << 25 """Btn""" RichText = 1 << 25 """Tx""" CommitOnSelChange = 1 << 26 """Ch""" @classmethod def attributes(cls) -> tuple[str, ...]: """ Get a tuple of all the attributes present in a Field Dictionary. This method returns a tuple of all the attribute constants defined in the FieldDictionaryAttributes class. These attributes correspond to the entries that are common to all field dictionaries as specified in the PDF 1.7 reference. Returns: A tuple containing all the attribute constants. """ return ( cls.TM, cls.T, cls.FT, cls.Parent, cls.TU, cls.Ff, cls.V, cls.DV, cls.Kids, cls.AA, ) @classmethod def attributes_dict(cls) -> dict[str, str]: """ Get a dictionary of attribute keys and their human-readable names. This method returns a dictionary where the keys are the attribute constants defined in the FieldDictionaryAttributes class and the values are their corresponding human-readable names. These attributes correspond to the entries that are common to all field dictionaries as specified in the PDF 1.7 reference. Returns: A dictionary containing attribute keys and their names. """ return { cls.FT: "Field Type", cls.Parent: "Parent", cls.T: "Field Name", cls.TU: "Alternate Field Name", cls.TM: "Mapping Name", cls.Ff: "Field Flags", cls.V: "Value", cls.DV: "Default Value", } class CheckboxRadioButtonAttributes: """Table 8.76 Field flags common to all field types.""" Opt = "/Opt" # Options, Optional @classmethod def attributes(cls) -> tuple[str, ...]: """ Get a tuple of all the attributes present in a Field Dictionary. This method returns a tuple of all the attribute constants defined in the CheckboxRadioButtonAttributes class. These attributes correspond to the entries that are common to all field dictionaries as specified in the PDF 1.7 reference. Returns: A tuple containing all the attribute constants. """ return (cls.Opt,) @classmethod def attributes_dict(cls) -> dict[str, str]: """ Get a dictionary of attribute keys and their human-readable names. This method returns a dictionary where the keys are the attribute constants defined in the CheckboxRadioButtonAttributes class and the values are their corresponding human-readable names. These attributes correspond to the entries that are common to all field dictionaries as specified in the PDF 1.7 reference. Returns: A dictionary containing attribute keys and their names. """ return { cls.Opt: "Options", } class FieldFlag(IntFlag): """Table 8.70 Field flags common to all field types.""" READ_ONLY = 1 REQUIRED = 2 NO_EXPORT = 4 class DocumentInformationAttributes: """Table 10.2 Entries in the document information dictionary.""" TITLE = "/Title" # text string, optional AUTHOR = "/Author" # text string, optional SUBJECT = "/Subject" # text string, optional KEYWORDS = "/Keywords" # text string, optional CREATOR = "/Creator" # text string, optional PRODUCER = "/Producer" # text string, optional CREATION_DATE = "/CreationDate" # date, optional MOD_DATE = "/ModDate" # date, optional TRAPPED = "/Trapped" # name, optional class PageLayouts: """ Page 84, PDF 1.4 reference. Page 115, PDF 2.0 reference. """ SINGLE_PAGE = "/SinglePage" ONE_COLUMN = "/OneColumn" TWO_COLUMN_LEFT = "/TwoColumnLeft" TWO_COLUMN_RIGHT = "/TwoColumnRight" TWO_PAGE_LEFT = "/TwoPageLeft" # (PDF 1.5) TWO_PAGE_RIGHT = "/TwoPageRight" # (PDF 1.5) class GraphicsStateParameters: """Table 58 – Entries in a Graphics State Parameter Dictionary""" TYPE = "/Type" # name, optional LW = "/LW" # number, optional LC = "/LC" # integer, optional LJ = "/LJ" # integer, optional ML = "/ML" # number, optional D = "/D" # array, optional RI = "/RI" # name, optional OP = "/OP" op = "/op" OPM = "/OPM" FONT = "/Font" # array, optional BG = "/BG" BG2 = "/BG2" UCR = "/UCR" UCR2 = "/UCR2" TR = "/TR" TR2 = "/TR2" HT = "/HT" FL = "/FL" SM = "/SM" SA = "/SA" BM = "/BM" S_MASK = "/SMask" # dictionary or name, optional CA = "/CA" ca = "/ca" AIS = "/AIS" TK = "/TK" class CatalogDictionary: """§7.7.2 of the 1.7 and 2.0 references.""" TYPE = "/Type" # name, required; must be /Catalog VERSION = "/Version" # name EXTENSIONS = "/Extensions" # dictionary, optional; ISO 32000-1 PAGES = "/Pages" # dictionary, required PAGE_LABELS = "/PageLabels" # number tree, optional NAMES = "/Names" # dictionary, optional DESTS = "/Dests" # dictionary, optional VIEWER_PREFERENCES = "/ViewerPreferences" # dictionary, optional PAGE_LAYOUT = "/PageLayout" # name, optional PAGE_MODE = "/PageMode" # name, optional OUTLINES = "/Outlines" # dictionary, optional THREADS = "/Threads" # array, optional OPEN_ACTION = "/OpenAction" # array or dictionary or name, optional AA = "/AA" # dictionary, optional URI = "/URI" # dictionary, optional ACRO_FORM = "/AcroForm" # dictionary, optional METADATA = "/Metadata" # stream, optional STRUCT_TREE_ROOT = "/StructTreeRoot" # dictionary, optional MARK_INFO = "/MarkInfo" # dictionary, optional LANG = "/Lang" # text string, optional SPIDER_INFO = "/SpiderInfo" # dictionary, optional OUTPUT_INTENTS = "/OutputIntents" # array, optional PIECE_INFO = "/PieceInfo" # dictionary, optional OC_PROPERTIES = "/OCProperties" # dictionary, optional PERMS = "/Perms" # dictionary, optional LEGAL = "/Legal" # dictionary, optional REQUIREMENTS = "/Requirements" # array, optional COLLECTION = "/Collection" # dictionary, optional NEEDS_RENDERING = "/NeedsRendering" # boolean, optional DSS = "/DSS" # dictionary, optional AF = "/AF" # array of dictionaries, optional D_PART_ROOT = "/DPartRoot" # dictionary, optional class OutlineFontFlag(IntFlag): """A class used as an enumerable flag for formatting an outline font.""" italic = 1 bold = 2 class PageLabelStyle: """ Table 8.10 in the 1.7 reference. Table 161 in the 2.0 reference. """ DECIMAL = "/D" # Decimal Arabic numerals UPPERCASE_ROMAN = "/R" # Uppercase Roman numerals LOWERCASE_ROMAN = "/r" # Lowercase Roman numerals UPPERCASE_LETTER = "/A" # Uppercase letters LOWERCASE_LETTER = "/a" # Lowercase letters class AnnotationFlag(IntFlag): """See §12.5.3 "Annotation Flags".""" INVISIBLE = 1 HIDDEN = 2 PRINT = 4 NO_ZOOM = 8 NO_ROTATE = 16 NO_VIEW = 32 READ_ONLY = 64 LOCKED = 128 TOGGLE_NO_VIEW = 256 LOCKED_CONTENTS = 512 PDF_KEYS = ( AnnotationDictionaryAttributes, CatalogAttributes, CatalogDictionary, CcittFaxDecodeParameters, CheckboxRadioButtonAttributes, ColorSpaces, Core, DocumentInformationAttributes, EncryptionDictAttributes, FieldDictionaryAttributes, FileSpecificationDictionaryEntries, FilterTypeAbbreviations, FilterTypes, GoToActionArguments, GraphicsStateParameters, ImageAttributes, InteractiveFormDictEntries, LzwFilterParameters, PageAttributes, PageLayouts, PagesAttributes, Resources, StreamAttributes, TrailerKeys, TypArguments, TypFitArguments, ) class ImageType(IntFlag): NONE = 0 XOBJECT_IMAGES = auto() INLINE_IMAGES = auto() DRAWING_IMAGES = auto() ALL = XOBJECT_IMAGES | INLINE_IMAGES | DRAWING_IMAGES IMAGES = ALL # for consistency with ObjectDeletionFlag _INLINE_IMAGE_VALUE_MAPPING = { "/G": "/DeviceGray", "/RGB": "/DeviceRGB", "/CMYK": "/DeviceCMYK", "/I": "/Indexed", "/AHx": "/ASCIIHexDecode", "/A85": "/ASCII85Decode", "/LZW": "/LZWDecode", "/Fl": "/FlateDecode", "/RL": "/RunLengthDecode", "/CCF": "/CCITTFaxDecode", "/DCT": "/DCTDecode", "/DeviceGray": "/DeviceGray", "/DeviceRGB": "/DeviceRGB", "/DeviceCMYK": "/DeviceCMYK", "/Indexed": "/Indexed", "/ASCIIHexDecode": "/ASCIIHexDecode", "/ASCII85Decode": "/ASCII85Decode", "/LZWDecode": "/LZWDecode", "/FlateDecode": "/FlateDecode", "/RunLengthDecode": "/RunLengthDecode", "/CCITTFaxDecode": "/CCITTFaxDecode", "/DCTDecode": "/DCTDecode", "/RelativeColorimetric": "/RelativeColorimetric", } _INLINE_IMAGE_KEY_MAPPING = { "/BPC": "/BitsPerComponent", "/CS": "/ColorSpace", "/D": "/Decode", "/DP": "/DecodeParms", "/F": "/Filter", "/H": "/Height", "/W": "/Width", "/I": "/Interpolate", "/Intent": "/Intent", "/IM": "/ImageMask", "/BitsPerComponent": "/BitsPerComponent", "/ColorSpace": "/ColorSpace", "/Decode": "/Decode", "/DecodeParms": "/DecodeParms", "/Filter": "/Filter", "/Height": "/Height", "/Width": "/Width", "/Interpolate": "/Interpolate", "/ImageMask": "/ImageMask", } class AFRelationship: """ Associated file relationship types, defining the relationship between the PDF component and the associated file. Defined in table 43 of the PDF 2.0 reference. """ SOURCE = "/Source" # Original content source DATA = "/Data" # Base data for visual presentation ALTERNATIVE = "/Alternative" # Alternative content representation SUPPLEMENT = "/Supplement" # Supplemental representation of original source/data ENCRYPTED_PAYLOAD = "/EncryptedPayload" # Encrypted payload document FORM_DATA = "/FormData" # Data associated with AcroForm of this PDF SCHEMA = "/Schema" # Schema definition for associated object UNSPECIFIED = "/Unspecified" # Not known or cannot be described with values pypdf-6.1.2/pypdf/errors.py000066400000000000000000000036331507516550200156650ustar00rootroot00000000000000""" All errors/exceptions pypdf raises and all of the warnings it uses. Please note that broken PDF files might cause other Exceptions. """ class DeprecationError(Exception): """Raised when a deprecated feature is used.""" class DependencyError(Exception): """ Raised when a required dependency (a library or module that pypdf depends on) is not available or cannot be imported. """ class PyPdfError(Exception): """Base class for all exceptions raised by pypdf.""" class PdfReadError(PyPdfError): """Raised when there is an issue reading a PDF file.""" class PageSizeNotDefinedError(PyPdfError): """Raised when the page size of a PDF document is not defined.""" class PdfReadWarning(UserWarning): """Issued when there is a potential issue reading a PDF file, but it can still be read.""" class PdfStreamError(PdfReadError): """Raised when there is an issue reading the stream of data in a PDF file.""" class ParseError(PyPdfError): """ Raised when there is an issue parsing (analyzing and understanding the structure and meaning of) a PDF file. """ class FileNotDecryptedError(PdfReadError): """ Raised when a PDF file that has been encrypted (meaning it requires a password to be accessed) has not been successfully decrypted. """ class WrongPasswordError(FileNotDecryptedError): """Raised when the wrong password is used to try to decrypt an encrypted PDF file.""" class EmptyFileError(PdfReadError): """Raised when a PDF file is empty or has no content.""" class EmptyImageDataError(PyPdfError): """Raised when trying to process an image that has no data.""" STREAM_TRUNCATED_PREMATURELY = "Stream has ended unexpectedly" class LimitReachedError(PyPdfError): """Raised when a limit is reached.""" class XmpDocumentError(PyPdfError, RuntimeError): """Raised when the XMP XML document context is invalid or missing.""" pypdf-6.1.2/pypdf/filters.py000066400000000000000000001022771507516550200160250ustar00rootroot00000000000000# Copyright (c) 2006, Mathieu Fenniak # All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. """ Implementation of stream filters; §7.4 Filters of the PDF 2.0 specification. §8.9.7 Inline images of the PDF 2.0 specification has abbreviations that can be used for the names of filters in an inline image object. """ __author__ = "Mathieu Fenniak" __author_email__ = "biziqe@mathieu.fenniak.net" import math import os import shutil import struct import subprocess import zlib from base64 import a85decode from dataclasses import dataclass from io import BytesIO from pathlib import Path from tempfile import TemporaryDirectory from typing import Any, Optional, Union, cast from ._codecs._codecs import LzwCodec as _LzwCodec from ._utils import ( WHITESPACES_AS_BYTES, deprecation_with_replacement, logger_warning, ) from .constants import CcittFaxDecodeParameters as CCITT from .constants import FilterTypeAbbreviations as FTA from .constants import FilterTypes as FT from .constants import ImageAttributes as IA from .constants import LzwFilterParameters as LZW from .constants import StreamAttributes as SA from .errors import DependencyError, LimitReachedError, PdfReadError, PdfStreamError from .generic import ( ArrayObject, DictionaryObject, IndirectObject, NullObject, StreamObject, is_null_or_none, ) ZLIB_MAX_OUTPUT_LENGTH = 75_000_000 def _decompress_with_limit(data: bytes) -> bytes: decompressor = zlib.decompressobj() result = decompressor.decompress(data, max_length=ZLIB_MAX_OUTPUT_LENGTH) if decompressor.unconsumed_tail: raise LimitReachedError( f"Limit reached while decompressing. {len(decompressor.unconsumed_tail)} bytes remaining." ) return result def decompress(data: bytes) -> bytes: """ Decompress the given data using zlib. Attempts to decompress the input data using zlib. If the decompression fails due to a zlib error, it falls back to using a decompression object with a larger window size. Please note that the output length is limited to avoid memory issues. If you need to process larger content streams, consider adapting ``pypdf.filters.ZLIB_MAX_OUTPUT_LENGTH``. In case you are only dealing with trusted inputs and/or want to disable these limits, set the value to `0`. Args: data: The input data to be decompressed. Returns: The decompressed data. """ try: return _decompress_with_limit(data) except zlib.error: # First quick approach: There are known issues with faulty added bytes to the # tail of the encoded stream from early Adobe Distiller or Pitstop versions # with CR char as the default line separator (assumed by reverse engineering) # that breaks the decoding process in the end. # # Try first to cut off some of the tail byte by byte, but limited to not # iterate through too many loops and kill the performance for large streams, # to then allow the final fallback to run. Added this intermediate attempt, # because starting from the head of the stream byte by byte kills completely # the performance for large streams (e.g., 6 MB) with the tail-byte-issue # and takes ages. This solution is really fast: max_tail_cut_off_bytes: int = 8 for i in range(1, min(max_tail_cut_off_bytes + 1, len(data))): try: return _decompress_with_limit(data[:-i]) except zlib.error: pass # If still failing, then try with increased window size. decompressor = zlib.decompressobj(zlib.MAX_WBITS | 32) result_str = b"" remaining_limit = ZLIB_MAX_OUTPUT_LENGTH data_single_bytes = [data[i : i + 1] for i in range(len(data))] for index, b in enumerate(data_single_bytes): try: decompressed = decompressor.decompress(b, max_length=remaining_limit) result_str += decompressed remaining_limit -= len(decompressed) if remaining_limit <= 0: raise LimitReachedError( f"Limit reached while decompressing. {len(data_single_bytes) - index} bytes remaining." ) except zlib.error: pass return result_str class FlateDecode: @staticmethod def decode( data: bytes, decode_parms: Optional[DictionaryObject] = None, **kwargs: Any, ) -> bytes: """ Decode data which is flate-encoded. Args: data: flate-encoded data. decode_parms: a dictionary of values, understanding the "/Predictor": key only Returns: The flate-decoded data. Raises: PdfReadError: """ str_data = decompress(data) predictor = 1 if decode_parms: try: predictor = decode_parms.get("/Predictor", 1) except (AttributeError, TypeError): # Type Error is NullObject pass # Usually an array with a null object was read # predictor 1 == no predictor if predictor != 1: # /Columns, the number of samples in each row, has a default value of 1; # §7.4.4.3, ISO 32000. DEFAULT_BITS_PER_COMPONENT = 8 try: columns = cast(int, decode_parms[LZW.COLUMNS].get_object()) # type: ignore except (TypeError, KeyError): columns = 1 try: colors = cast(int, decode_parms[LZW.COLORS].get_object()) # type: ignore except (TypeError, KeyError): colors = 1 try: bits_per_component = cast( int, decode_parms[LZW.BITS_PER_COMPONENT].get_object(), # type: ignore ) except (TypeError, KeyError): bits_per_component = DEFAULT_BITS_PER_COMPONENT # PNG predictor can vary by row and so is the lead byte on each row rowlength = ( math.ceil(columns * colors * bits_per_component / 8) + 1 ) # number of bytes # TIFF prediction: if predictor == 2: rowlength -= 1 # remove the predictor byte bpp = rowlength // columns str_data = bytearray(str_data) for i in range(len(str_data)): if i % rowlength >= bpp: str_data[i] = (str_data[i] + str_data[i - bpp]) % 256 str_data = bytes(str_data) # PNG prediction: elif 10 <= predictor <= 15: str_data = FlateDecode._decode_png_prediction( str_data, columns, rowlength ) else: raise PdfReadError(f"Unsupported flatedecode predictor {predictor!r}") return str_data @staticmethod def _decode_png_prediction(data: bytes, columns: int, rowlength: int) -> bytes: # PNG prediction can vary from row to row if (remainder := len(data) % rowlength) != 0: logger_warning("Image data is not rectangular. Adding padding.", __name__) data += b"\x00" * (rowlength - remainder) assert len(data) % rowlength == 0 output = [] prev_rowdata = (0,) * rowlength bpp = (rowlength - 1) // columns # recomputed locally to not change params for row in range(0, len(data), rowlength): rowdata: list[int] = list(data[row : row + rowlength]) filter_byte = rowdata[0] if filter_byte == 0: # PNG None Predictor pass elif filter_byte == 1: # PNG Sub Predictor for i in range(bpp + 1, rowlength): rowdata[i] = (rowdata[i] + rowdata[i - bpp]) % 256 elif filter_byte == 2: # PNG Up Predictor for i in range(1, rowlength): rowdata[i] = (rowdata[i] + prev_rowdata[i]) % 256 elif filter_byte == 3: # PNG Average Predictor for i in range(1, bpp + 1): floor = prev_rowdata[i] // 2 rowdata[i] = (rowdata[i] + floor) % 256 for i in range(bpp + 1, rowlength): left = rowdata[i - bpp] floor = (left + prev_rowdata[i]) // 2 rowdata[i] = (rowdata[i] + floor) % 256 elif filter_byte == 4: # PNG Paeth Predictor for i in range(1, bpp + 1): rowdata[i] = (rowdata[i] + prev_rowdata[i]) % 256 for i in range(bpp + 1, rowlength): left = rowdata[i - bpp] up = prev_rowdata[i] up_left = prev_rowdata[i - bpp] p = left + up - up_left dist_left = abs(p - left) dist_up = abs(p - up) dist_up_left = abs(p - up_left) if dist_left <= dist_up and dist_left <= dist_up_left: paeth = left elif dist_up <= dist_up_left: paeth = up else: paeth = up_left rowdata[i] = (rowdata[i] + paeth) % 256 else: raise PdfReadError( f"Unsupported PNG filter {filter_byte!r}" ) # pragma: no cover prev_rowdata = tuple(rowdata) output.extend(rowdata[1:]) return bytes(output) @staticmethod def encode(data: bytes, level: int = -1) -> bytes: """ Compress the input data using zlib. Args: data: The data to be compressed. level: See https://docs.python.org/3/library/zlib.html#zlib.compress Returns: The compressed data. """ return zlib.compress(data, level) class ASCIIHexDecode: """ The ASCIIHexDecode filter decodes data that has been encoded in ASCII hexadecimal form into a base-7 ASCII format. """ @staticmethod def decode( data: Union[str, bytes], decode_parms: Optional[DictionaryObject] = None, **kwargs: Any, ) -> bytes: """ Decode an ASCII-Hex encoded data stream. Args: data: a str sequence of hexadecimal-encoded values to be converted into a base-7 ASCII string decode_parms: this filter does not use parameters. Returns: A string conversion in base-7 ASCII, where each of its values v is such that 0 <= ord(v) <= 127. Raises: PdfStreamError: """ if isinstance(data, str): data = data.encode() retval = b"" hex_pair = b"" index = 0 while True: if index >= len(data): logger_warning( "missing EOD in ASCIIHexDecode, check if output is OK", __name__ ) break # Reached end of string without an EOD char = data[index : index + 1] if char == b">": break if char.isspace(): index += 1 continue hex_pair += char if len(hex_pair) == 2: retval += bytes((int(hex_pair, base=16),)) hex_pair = b"" index += 1 # If the filter encounters the EOD marker after reading # an odd number of hexadecimal digits, # it shall behave as if a 0 (zero) followed the last digit. # For every even number of hexadecimal digits, hex_pair is reset to b"". if hex_pair != b"": hex_pair += b"0" retval += bytes((int(hex_pair, base=16),)) return retval class RunLengthDecode: """ The RunLengthDecode filter decodes data that has been encoded in a simple byte-oriented format based on run length. The encoded data is a sequence of runs, where each run consists of a length byte followed by 1 to 128 bytes of data. If the length byte is in the range 0 to 127, the following length + 1 (1 to 128) bytes are copied literally during decompression. If length is in the range 129 to 255, the following single byte is to be copied 257 â’ length (2 to 128) times during decompression. A length value of 128 denotes EOD. """ @staticmethod def decode( data: bytes, decode_parms: Optional[DictionaryObject] = None, **kwargs: Any, ) -> bytes: """ Decode a run length encoded data stream. Args: data: a bytes sequence of length/data decode_parms: this filter does not use parameters. Returns: A bytes decompressed sequence. Raises: PdfStreamError: """ lst = [] index = 0 while True: if index >= len(data): logger_warning( "missing EOD in RunLengthDecode, check if output is OK", __name__ ) break # Reached end of string without an EOD length = data[index] index += 1 if length == 128: data_length = len(data) if index < data_length: # We should first check, if we have an inner stream from a multi-encoded # stream with a faulty trailing newline that we can decode properly. # We will just ignore the last byte and raise a warning ... if (index == data_length - 1) and (data[index : index+1] == b"\n"): logger_warning( "Found trailing newline in stream data, check if output is OK", __name__ ) break raise PdfStreamError("Early EOD in RunLengthDecode") break if length < 128: length += 1 lst.append(data[index : (index + length)]) index += length else: # >128 length = 257 - length lst.append(bytes((data[index],)) * length) index += 1 return b"".join(lst) class LZWDecode: class Decoder: STOP = 257 CLEARDICT = 256 def __init__(self, data: bytes) -> None: self.data = data def decode(self) -> bytes: return _LzwCodec().decode(self.data) @staticmethod def decode( data: bytes, decode_parms: Optional[DictionaryObject] = None, **kwargs: Any, ) -> bytes: """ Decode an LZW encoded data stream. Args: data: ``bytes`` or ``str`` text to decode. decode_parms: a dictionary of parameter values. Returns: decoded data. """ # decode_parms is unused here return LZWDecode.Decoder(data).decode() class ASCII85Decode: """Decodes string ASCII85-encoded data into a byte format.""" @staticmethod def decode( data: Union[str, bytes], decode_parms: Optional[DictionaryObject] = None, **kwargs: Any, ) -> bytes: """ Decode an Ascii85 encoded data stream. Args: data: ``bytes`` or ``str`` text to decode. decode_parms: this filter does not use parameters. Returns: decoded data. """ if isinstance(data, str): data = data.encode() data = data.strip(WHITESPACES_AS_BYTES) try: return a85decode(data, adobe=True, ignorechars=WHITESPACES_AS_BYTES) except ValueError as error: if error.args[0] == "Ascii85 encoded byte sequences must end with b'~>'": logger_warning("Ignoring missing Ascii85 end marker.", __name__) return a85decode(data, adobe=False, ignorechars=WHITESPACES_AS_BYTES) raise class DCTDecode: @staticmethod def decode( data: bytes, decode_parms: Optional[DictionaryObject] = None, **kwargs: Any, ) -> bytes: """ Decompresses data encoded using a DCT (discrete cosine transform) technique based on the JPEG standard (IS0/IEC 10918), reproducing image sample data that approximates the original data. Args: data: text to decode. decode_parms: this filter does not use parameters. Returns: decoded data. """ return data class JPXDecode: @staticmethod def decode( data: bytes, decode_parms: Optional[DictionaryObject] = None, **kwargs: Any, ) -> bytes: """ Decompresses data encoded using the wavelet-based JPEG 2000 standard, reproducing the original image data. Args: data: text to decode. decode_parms: this filter does not use parameters. Returns: decoded data. """ return data @dataclass class CCITTParameters: """§7.4.6, optional parameters for the CCITTFaxDecode filter.""" K: int = 0 columns: int = 1728 rows: int = 0 EndOfLine: Union[bool, None] = False EncodedByteAlign: Union[bool, None] = False EndOfBlock: Union[bool, None] = True BlackIs1: bool = False DamagedRowsBeforeError: Union[int, None] = 0 @property def group(self) -> int: if self.K < 0: # Pure two-dimensional encoding (Group 4) CCITTgroup = 4 else: # K == 0: Pure one-dimensional encoding (Group 3, 1-D) # K > 0: Mixed one- and two-dimensional encoding (Group 3, 2-D) CCITTgroup = 3 return CCITTgroup def __create_old_class_instance( K: int = 0, columns: int = 0, rows: int = 0 ) -> CCITTParameters: deprecation_with_replacement("CCITParameters", "CCITTParameters", "6.0.0") return CCITTParameters(K, columns, rows) # Create an alias for the old class name CCITParameters = __create_old_class_instance class CCITTFaxDecode: """ §7.4.6, CCITTFaxDecode filter (ISO 32000). Either Group 3 or Group 4 CCITT facsimile (fax) encoding. CCITT encoding is bit-oriented, not byte-oriented. §7.4.6, optional parameters for the CCITTFaxDecode filter. """ @staticmethod def _get_parameters( parameters: Union[None, ArrayObject, DictionaryObject, IndirectObject], rows: Union[int, IndirectObject], ) -> CCITTParameters: ccitt_parameters = CCITTParameters(rows=int(rows)) if parameters: parameters_unwrapped = cast( Union[ArrayObject, DictionaryObject], parameters.get_object() ) if isinstance(parameters_unwrapped, ArrayObject): for decode_parm in parameters_unwrapped: if CCITT.K in decode_parm: ccitt_parameters.K = decode_parm[CCITT.K].get_object() if CCITT.COLUMNS in decode_parm: ccitt_parameters.columns = decode_parm[CCITT.COLUMNS].get_object() if CCITT.BLACK_IS_1 in decode_parm: ccitt_parameters.BlackIs1 = decode_parm[CCITT.BLACK_IS_1].get_object().value else: if CCITT.K in parameters_unwrapped: ccitt_parameters.K = parameters_unwrapped[CCITT.K].get_object() # type: ignore if CCITT.COLUMNS in parameters_unwrapped: ccitt_parameters.columns = parameters_unwrapped[CCITT.COLUMNS].get_object() # type: ignore if CCITT.BLACK_IS_1 in parameters_unwrapped: ccitt_parameters.BlackIs1 = parameters_unwrapped[CCITT.BLACK_IS_1].get_object().value # type: ignore return ccitt_parameters @staticmethod def decode( data: bytes, decode_parms: Optional[DictionaryObject] = None, height: int = 0, **kwargs: Any, ) -> bytes: params = CCITTFaxDecode._get_parameters(decode_parms, height) img_size = len(data) tiff_header_struct = "<2shlh" + "hhll" * 8 + "h" tiff_header = struct.pack( tiff_header_struct, b"II", # Byte order indication: Little endian 42, # Version number (always 42) 8, # Offset to the first image file directory (IFD) 8, # Number of tags in IFD 256, # ImageWidth, LONG, 1, width 4, 1, params.columns, 257, # ImageLength, LONG, 1, length 4, 1, params.rows, 258, # BitsPerSample, SHORT, 1, 1 3, 1, 1, 259, # Compression, SHORT, 1, compression Type 3, 1, params.group, 262, # Thresholding, SHORT, 1, 0 = BlackIs1 3, 1, int(params.BlackIs1), 273, # StripOffsets, LONG, 1, length of header 4, 1, struct.calcsize( tiff_header_struct ), 278, # RowsPerStrip, LONG, 1, length 4, 1, params.rows, 279, # StripByteCounts, LONG, 1, size of image 4, 1, img_size, 0, # last IFD ) return tiff_header + data JBIG2DEC_BINARY = shutil.which("jbig2dec") class JBIG2Decode: @staticmethod def decode( data: bytes, decode_parms: Optional[DictionaryObject] = None, **kwargs: Any, ) -> bytes: if JBIG2DEC_BINARY is None: raise DependencyError("jbig2dec binary is not available.") with TemporaryDirectory() as tempdir: directory = Path(tempdir) paths: list[Path] = [] if decode_parms and "/JBIG2Globals" in decode_parms: jbig2_globals = decode_parms["/JBIG2Globals"] if not is_null_or_none(jbig2_globals) and not is_null_or_none(pointer := jbig2_globals.get_object()): assert pointer is not None, "mypy" if isinstance(pointer, StreamObject): path = directory.joinpath("globals.jbig2") path.write_bytes(pointer.get_data()) paths.append(path) path = directory.joinpath("image.jbig2") path.write_bytes(data) paths.append(path) environment = os.environ.copy() environment["LC_ALL"] = "C" result = subprocess.run( # noqa: S603 [JBIG2DEC_BINARY, "--embedded", "--format", "png", "--output", "-", *paths], capture_output=True, env=environment, ) if b"unrecognized option '--embedded'" in result.stderr: raise DependencyError("jbig2dec>=0.15 is required.") if result.stderr: for line in result.stderr.decode("utf-8").splitlines(): logger_warning(line, __name__) if result.returncode != 0: raise PdfStreamError(f"Unable to decode JBIG2 data. Exit code: {result.returncode}") return result.stdout @staticmethod def _is_binary_compatible() -> bool: if not JBIG2DEC_BINARY: # pragma: no cover return False result = subprocess.run( # noqa: S603 [JBIG2DEC_BINARY, "--version"], capture_output=True, text=True, ) version = result.stdout.split(" ", maxsplit=1)[1] from ._utils import Version # noqa: PLC0415 return Version(version) >= Version("0.15") def decode_stream_data(stream: Any) -> bytes: """ Decode the stream data based on the specified filters. This function decodes the stream data using the filters provided in the stream. Args: stream: The input stream object containing the data and filters. Returns: The decoded stream data. Raises: NotImplementedError: If an unsupported filter type is encountered. """ filters = stream.get(SA.FILTER, ()) if isinstance(filters, IndirectObject): filters = cast(ArrayObject, filters.get_object()) if not isinstance(filters, ArrayObject): # We have a single filter instance filters = (filters,) decode_parms = stream.get(SA.DECODE_PARMS, ({},) * len(filters)) if not isinstance(decode_parms, (list, tuple)): decode_parms = (decode_parms,) data: bytes = stream._data # If there is no data to decode, we should not try to decode it. if not data: return data for filter_name, params in zip(filters, decode_parms): if isinstance(params, NullObject): params = {} if filter_name in (FT.ASCII_HEX_DECODE, FTA.AHx): data = ASCIIHexDecode.decode(data) elif filter_name in (FT.ASCII_85_DECODE, FTA.A85): data = ASCII85Decode.decode(data) elif filter_name in (FT.LZW_DECODE, FTA.LZW): data = LZWDecode.decode(data, params) elif filter_name in (FT.FLATE_DECODE, FTA.FL): data = FlateDecode.decode(data, params) elif filter_name in (FT.RUN_LENGTH_DECODE, FTA.RL): data = RunLengthDecode.decode(data) elif filter_name == FT.CCITT_FAX_DECODE: height = stream.get(IA.HEIGHT, ()) data = CCITTFaxDecode.decode(data, params, height) elif filter_name == FT.DCT_DECODE: data = DCTDecode.decode(data) elif filter_name == FT.JPX_DECODE: data = JPXDecode.decode(data) elif filter_name == FT.JBIG2_DECODE: data = JBIG2Decode.decode(data, params) elif filter_name == "/Crypt": if "/Name" in params or "/Type" in params: raise NotImplementedError( "/Crypt filter with /Name or /Type not supported yet" ) else: raise NotImplementedError(f"Unsupported filter {filter_name}") return data def _xobj_to_image(x_object: dict[str, Any]) -> tuple[Optional[str], bytes, Any]: """ Users need to have the pillow package installed. It's unclear if pypdf will keep this function here, hence it's private. It might get removed at any point. Args: x_object: Returns: Tuple[file extension, bytes, PIL.Image.Image] """ from ._xobj_image_helpers import ( # noqa: PLC0415 Image, UnidentifiedImageError, _apply_decode, _extended_image_frombytes, _get_mode_and_invert_color, _handle_flate, _handle_jpx, ) def _apply_alpha( img: Image.Image, x_object: dict[str, Any], obj_as_text: str, image_format: str, extension: str, ) -> tuple[Image.Image, str, str]: alpha = None if IA.S_MASK in x_object: # add alpha channel alpha = _xobj_to_image(x_object[IA.S_MASK])[2] if img.size != alpha.size: logger_warning( f"image and mask size not matching: {obj_as_text}", __name__ ) else: # TODO: implement mask if alpha.mode != "L": alpha = alpha.convert("L") if img.mode == "P": img = img.convert("RGB") elif img.mode == "1": img = img.convert("L") img.putalpha(alpha) if "JPEG" in image_format: image_format = "JPEG2000" extension = ".jp2" else: image_format = "PNG" extension = ".png" return img, extension, image_format # For error reporting obj_as_text = ( x_object.indirect_reference.__repr__() if x_object is None # pragma: no cover else x_object.__repr__() ) # Get size and data size = (cast(int, x_object[IA.WIDTH]), cast(int, x_object[IA.HEIGHT])) data = x_object.get_data() # type: ignore if isinstance(data, str): # pragma: no cover data = data.encode() if len(data) % (size[0] * size[1]) == 1 and data[-1] == 0x0A: # ie. '\n' data = data[:-1] # Get color properties colors = x_object.get("/Colors", 1) color_space: Any = x_object.get("/ColorSpace", NullObject()).get_object() if isinstance(color_space, list) and len(color_space) == 1: color_space = color_space[0].get_object() mode, invert_color = _get_mode_and_invert_color(x_object, colors, color_space) # Get filters filters = x_object.get(SA.FILTER, NullObject()).get_object() lfilters = filters[-1] if isinstance(filters, list) else filters decode_parms = x_object.get(SA.DECODE_PARMS, None) if decode_parms and isinstance(decode_parms, (tuple, list)): decode_parms = decode_parms[0] else: decode_parms = {} if not isinstance(decode_parms, dict): decode_parms = {} extension = None if lfilters in (FT.FLATE_DECODE, FT.RUN_LENGTH_DECODE): img, image_format, extension, _ = _handle_flate( size, data, mode, color_space, colors, obj_as_text, ) elif lfilters in (FT.LZW_DECODE, FT.ASCII_85_DECODE): # I'm not sure if the following logic is correct. # There might not be any relationship between the filters and the # extension if lfilters == FT.LZW_DECODE: image_format = "TIFF" extension = ".tiff" # mime_type = "image/tiff" else: image_format = "PNG" extension = ".png" # mime_type = "image/png" try: img = Image.open(BytesIO(data), formats=("TIFF", "PNG")) except UnidentifiedImageError: img = _extended_image_frombytes(mode, size, data) elif lfilters == FT.DCT_DECODE: img, image_format, extension = Image.open(BytesIO(data)), "JPEG", ".jpg" # invert_color kept unchanged elif lfilters == FT.JPX_DECODE: img, image_format, extension, invert_color = _handle_jpx( size, data, mode, color_space, colors ) elif lfilters == FT.CCITT_FAX_DECODE: img, image_format, extension, invert_color = ( Image.open(BytesIO(data), formats=("TIFF",)), "TIFF", ".tiff", False, ) elif lfilters == FT.JBIG2_DECODE: img, image_format, extension, invert_color = ( Image.open(BytesIO(data), formats=("PNG",)), "PNG", ".png", False, ) elif mode == "CMYK": img, image_format, extension, invert_color = ( _extended_image_frombytes(mode, size, data), "TIFF", ".tif", False, ) elif mode == "": raise PdfReadError(f"ColorSpace field not found in {x_object}") else: img, image_format, extension, invert_color = ( _extended_image_frombytes(mode, size, data), "PNG", ".png", False, ) img = _apply_decode(img, x_object, lfilters, color_space, invert_color) img, extension, image_format = _apply_alpha( img, x_object, obj_as_text, image_format, extension ) # Save image to bytes img_byte_arr = BytesIO() try: img.save(img_byte_arr, format=image_format) except OSError: # pragma: no cover # covered with pillow 10.3 # in case of we convert to RGBA and then to PNG img1 = img.convert("RGBA") image_format = "PNG" extension = ".png" img_byte_arr = BytesIO() img1.save(img_byte_arr, format=image_format) data = img_byte_arr.getvalue() try: # temporary try/except until other fixes of images img = Image.open(BytesIO(data)) except Exception as exception: logger_warning(f"Failed loading image: {exception}", __name__) img = None # type: ignore return extension, data, img pypdf-6.1.2/pypdf/generic/000077500000000000000000000000001507516550200154065ustar00rootroot00000000000000pypdf-6.1.2/pypdf/generic/__init__.py000066400000000000000000000066141507516550200175260ustar00rootroot00000000000000# Copyright (c) 2006, Mathieu Fenniak # All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. """Implementation of generic PDF objects (dictionary, number, string, ...).""" __author__ = "Mathieu Fenniak" __author_email__ = "biziqe@mathieu.fenniak.net" from ..constants import OutlineFontFlag from ._base import ( BooleanObject, ByteStringObject, FloatObject, IndirectObject, NameObject, NullObject, NumberObject, PdfObject, TextStringObject, encode_pdfdocencoding, is_null_or_none, ) from ._data_structures import ( ArrayObject, ContentStream, DecodedStreamObject, Destination, DictionaryObject, EncodedStreamObject, Field, StreamObject, TreeObject, read_object, ) from ._files import EmbeddedFile from ._fit import Fit from ._link import DirectReferenceLink, NamedReferenceLink, ReferenceLink, extract_links from ._outline import OutlineItem from ._rectangle import RectangleObject from ._utils import ( create_string_object, decode_pdfdocencoding, hex_to_rgb, read_hex_string_from_stream, read_string_from_stream, ) from ._viewerpref import ViewerPreferences PAGE_FIT = Fit.fit() __all__ = [ "PAGE_FIT", "ArrayObject", "BooleanObject", "ByteStringObject", "ContentStream", "DecodedStreamObject", "Destination", "DictionaryObject", "DirectReferenceLink", "EmbeddedFile", "EncodedStreamObject", "Field", "Fit", "FloatObject", "IndirectObject", "NameObject", "NamedReferenceLink", "NullObject", "NumberObject", "OutlineFontFlag", "OutlineItem", "PdfObject", "RectangleObject", "ReferenceLink", "StreamObject", "TextStringObject", "TreeObject", "ViewerPreferences", # Utility functions "create_string_object", "decode_pdfdocencoding", "encode_pdfdocencoding", "extract_links", "hex_to_rgb", "is_null_or_none", "read_hex_string_from_stream", # Data structures core functions "read_object", "read_string_from_stream", ] pypdf-6.1.2/pypdf/generic/_base.py000066400000000000000000000760161507516550200170430ustar00rootroot00000000000000# Copyright (c) 2006, Mathieu Fenniak # All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. import binascii import codecs import hashlib import re import sys from binascii import unhexlify from collections.abc import Sequence from math import log10 from struct import iter_unpack from typing import Any, Callable, ClassVar, Optional, Union, cast if sys.version_info[:2] >= (3, 10): from typing import TypeGuard else: from typing_extensions import TypeGuard # PEP 647 from .._codecs import _pdfdoc_encoding_rev from .._protocols import PdfObjectProtocol, PdfWriterProtocol from .._utils import ( StreamType, classproperty, deprecation_no_replacement, deprecation_with_replacement, logger_warning, read_non_whitespace, read_until_regex, ) from ..errors import STREAM_TRUNCATED_PREMATURELY, PdfReadError, PdfStreamError __author__ = "Mathieu Fenniak" __author_email__ = "biziqe@mathieu.fenniak.net" class PdfObject(PdfObjectProtocol): # function for calculating a hash value hash_func: Callable[..., "hashlib._Hash"] = hashlib.sha1 indirect_reference: Optional["IndirectObject"] def hash_bin(self) -> int: """ Used to detect modified object. Returns: Hash considering type and value. """ raise NotImplementedError( f"{self.__class__.__name__} does not implement .hash_bin() so far" ) def hash_value_data(self) -> bytes: return f"{self}".encode() def hash_value(self) -> bytes: return ( f"{self.__class__.__name__}:" f"{self.hash_func(self.hash_value_data()).hexdigest()}" ).encode() def replicate( self, pdf_dest: PdfWriterProtocol, ) -> "PdfObject": """ Clone object into pdf_dest (PdfWriterProtocol which is an interface for PdfWriter) without ensuring links. This is used in clone_document_from_root with incremental = True. Args: pdf_dest: Target to clone to. Returns: The cloned PdfObject """ return self.clone(pdf_dest) def clone( self, pdf_dest: PdfWriterProtocol, force_duplicate: bool = False, ignore_fields: Optional[Sequence[Union[str, int]]] = (), ) -> "PdfObject": """ Clone object into pdf_dest (PdfWriterProtocol which is an interface for PdfWriter). By default, this method will call ``_reference_clone`` (see ``_reference``). Args: pdf_dest: Target to clone to. force_duplicate: By default, if the object has already been cloned and referenced, the copy will be returned; when ``True``, a new copy will be created. (Default value = ``False``) ignore_fields: List/tuple of field names (for dictionaries) that will be ignored during cloning (applies to children duplication as well). If fields are to be considered for a limited number of levels, you have to add it as integer, for example ``[1,"/B","/TOTO"]`` means that ``"/B"`` will be ignored at the first level only but ``"/TOTO"`` on all levels. Returns: The cloned PdfObject """ raise NotImplementedError( f"{self.__class__.__name__} does not implement .clone so far" ) def _reference_clone( self, clone: Any, pdf_dest: PdfWriterProtocol, force_duplicate: bool = False ) -> PdfObjectProtocol: """ Reference the object within the _objects of pdf_dest only if indirect_reference attribute exists (which means the objects was already identified in xref/xobjstm) if object has been already referenced do nothing. Args: clone: pdf_dest: Returns: The clone """ try: if not force_duplicate and clone.indirect_reference.pdf == pdf_dest: return clone except Exception: pass # if hasattr(clone, "indirect_reference"): try: ind = self.indirect_reference except AttributeError: return clone if ( pdf_dest.incremental and ind is not None and ind.pdf == pdf_dest._reader and ind.idnum <= len(pdf_dest._objects) ): i = ind.idnum else: i = len(pdf_dest._objects) + 1 if ind is not None: if id(ind.pdf) not in pdf_dest._id_translated: pdf_dest._id_translated[id(ind.pdf)] = {} pdf_dest._id_translated[id(ind.pdf)]["PreventGC"] = ind.pdf # type: ignore if ( not force_duplicate and ind.idnum in pdf_dest._id_translated[id(ind.pdf)] ): obj = pdf_dest.get_object( pdf_dest._id_translated[id(ind.pdf)][ind.idnum] ) assert obj is not None return obj pdf_dest._id_translated[id(ind.pdf)][ind.idnum] = i try: pdf_dest._objects[i - 1] = clone except IndexError: pdf_dest._objects.append(clone) i = len(pdf_dest._objects) clone.indirect_reference = IndirectObject(i, 0, pdf_dest) return clone def get_object(self) -> Optional["PdfObject"]: """Resolve indirect references.""" return self def write_to_stream( self, stream: StreamType, encryption_key: Union[None, str, bytes] = None ) -> None: raise NotImplementedError class NullObject(PdfObject): def clone( self, pdf_dest: PdfWriterProtocol, force_duplicate: bool = False, ignore_fields: Optional[Sequence[Union[str, int]]] = (), ) -> "NullObject": """Clone object into pdf_dest.""" return cast( "NullObject", self._reference_clone(NullObject(), pdf_dest, force_duplicate) ) def hash_bin(self) -> int: """ Used to detect modified object. Returns: Hash considering type and value. """ return hash((self.__class__,)) def write_to_stream( self, stream: StreamType, encryption_key: Union[None, str, bytes] = None ) -> None: if encryption_key is not None: # deprecated deprecation_no_replacement( "the encryption_key parameter of write_to_stream", "5.0.0" ) stream.write(b"null") @staticmethod def read_from_stream(stream: StreamType) -> "NullObject": nulltxt = stream.read(4) if nulltxt != b"null": raise PdfReadError("Could not read Null object") return NullObject() def __repr__(self) -> str: return "NullObject" def __eq__(self, other: object) -> bool: return isinstance(other, NullObject) def __hash__(self) -> int: return self.hash_bin() class BooleanObject(PdfObject): def __init__(self, value: Any) -> None: self.value = value def clone( self, pdf_dest: PdfWriterProtocol, force_duplicate: bool = False, ignore_fields: Optional[Sequence[Union[str, int]]] = (), ) -> "BooleanObject": """Clone object into pdf_dest.""" return cast( "BooleanObject", self._reference_clone(BooleanObject(self.value), pdf_dest, force_duplicate), ) def hash_bin(self) -> int: """ Used to detect modified object. Returns: Hash considering type and value. """ return hash((self.__class__, self.value)) def __eq__(self, o: object, /) -> bool: if isinstance(o, BooleanObject): return self.value == o.value if isinstance(o, bool): return self.value == o return False def __hash__(self) -> int: return self.hash_bin() def __repr__(self) -> str: return "True" if self.value else "False" def write_to_stream( self, stream: StreamType, encryption_key: Union[None, str, bytes] = None ) -> None: if encryption_key is not None: # deprecated deprecation_no_replacement( "the encryption_key parameter of write_to_stream", "5.0.0" ) if self.value: stream.write(b"true") else: stream.write(b"false") @staticmethod def read_from_stream(stream: StreamType) -> "BooleanObject": word = stream.read(4) if word == b"true": return BooleanObject(True) if word == b"fals": stream.read(1) return BooleanObject(False) raise PdfReadError("Could not read Boolean object") class IndirectObject(PdfObject): def __init__(self, idnum: int, generation: int, pdf: Any) -> None: # PdfReader self.idnum = idnum self.generation = generation self.pdf = pdf def __hash__(self) -> int: return hash((self.idnum, self.generation, id(self.pdf))) def hash_bin(self) -> int: """ Used to detect modified object. Returns: Hash considering type and value. """ return hash((self.__class__, self.idnum, self.generation, id(self.pdf))) def replicate( self, pdf_dest: PdfWriterProtocol, ) -> "PdfObject": return IndirectObject(self.idnum, self.generation, pdf_dest) def clone( self, pdf_dest: PdfWriterProtocol, force_duplicate: bool = False, ignore_fields: Optional[Sequence[Union[str, int]]] = (), ) -> "IndirectObject": """Clone object into pdf_dest.""" if self.pdf == pdf_dest and not force_duplicate: # Already duplicated and no extra duplication required return self if id(self.pdf) not in pdf_dest._id_translated: pdf_dest._id_translated[id(self.pdf)] = {} if self.idnum in pdf_dest._id_translated[id(self.pdf)]: dup = pdf_dest.get_object(pdf_dest._id_translated[id(self.pdf)][self.idnum]) if force_duplicate: assert dup is not None assert dup.indirect_reference is not None idref = dup.indirect_reference return IndirectObject(idref.idnum, idref.generation, idref.pdf) else: obj = self.get_object() # case observed : a pointed object can not be found if obj is None: # this normally obj = NullObject() assert isinstance(self, (IndirectObject,)) obj.indirect_reference = self dup = pdf_dest._add_object( obj.clone(pdf_dest, force_duplicate, ignore_fields) ) assert dup is not None, "mypy" assert dup.indirect_reference is not None, "mypy" return dup.indirect_reference @property def indirect_reference(self) -> "IndirectObject": # type: ignore[override] return self def get_object(self) -> Optional["PdfObject"]: return self.pdf.get_object(self) def __deepcopy__(self, memo: Any) -> "IndirectObject": return IndirectObject(self.idnum, self.generation, self.pdf) def _get_object_with_check(self) -> Optional["PdfObject"]: o = self.get_object() # the check is done here to not slow down get_object() if isinstance(o, IndirectObject): raise PdfStreamError( f"{self.__repr__()} references an IndirectObject {o.__repr__()}" ) return o def __getattr__(self, name: str) -> Any: # Attribute not found in object: look in pointed object try: return getattr(self._get_object_with_check(), name) except AttributeError: raise AttributeError( f"No attribute {name} found in IndirectObject or pointed object" ) def __getitem__(self, key: Any) -> Any: # items should be extracted from pointed Object return self._get_object_with_check()[key] # type: ignore def __contains__(self, key: Any) -> bool: return key in self._get_object_with_check() # type: ignore def __iter__(self) -> Any: return self._get_object_with_check().__iter__() # type: ignore def __float__(self) -> str: # in this case we are looking for the pointed data return self.get_object().__float__() # type: ignore def __int__(self) -> int: # in this case we are looking for the pointed data return self.get_object().__int__() # type: ignore def __str__(self) -> str: # in this case we are looking for the pointed data return self.get_object().__str__() def __repr__(self) -> str: return f"IndirectObject({self.idnum!r}, {self.generation!r}, {id(self.pdf)})" def __eq__(self, other: object) -> bool: return ( other is not None and isinstance(other, IndirectObject) and self.idnum == other.idnum and self.generation == other.generation and self.pdf is other.pdf ) def __ne__(self, other: object) -> bool: return not self.__eq__(other) def write_to_stream( self, stream: StreamType, encryption_key: Union[None, str, bytes] = None ) -> None: if encryption_key is not None: # deprecated deprecation_no_replacement( "the encryption_key parameter of write_to_stream", "5.0.0" ) stream.write(f"{self.idnum} {self.generation} R".encode()) @staticmethod def read_from_stream(stream: StreamType, pdf: Any) -> "IndirectObject": # PdfReader idnum = b"" while True: tok = stream.read(1) if not tok: raise PdfStreamError(STREAM_TRUNCATED_PREMATURELY) if tok.isspace(): break idnum += tok generation = b"" while True: tok = stream.read(1) if not tok: raise PdfStreamError(STREAM_TRUNCATED_PREMATURELY) if tok.isspace(): if not generation: continue break generation += tok r = read_non_whitespace(stream) if r != b"R": raise PdfReadError( f"Error reading indirect object reference at byte {hex(stream.tell())}" ) return IndirectObject(int(idnum), int(generation), pdf) FLOAT_WRITE_PRECISION = 8 # shall be min 5 digits max, allow user adj class FloatObject(float, PdfObject): def __new__( cls, value: Any = "0.0", context: Optional[Any] = None ) -> "FloatObject": try: value = float(value) return float.__new__(cls, value) except Exception as e: # If this isn't a valid decimal (happens in malformed PDFs) # fallback to 0 logger_warning( f"{e} : FloatObject ({value}) invalid; use 0.0 instead", __name__ ) return float.__new__(cls, 0.0) def clone( self, pdf_dest: Any, force_duplicate: bool = False, ignore_fields: Optional[Sequence[Union[str, int]]] = (), ) -> "FloatObject": """Clone object into pdf_dest.""" return cast( "FloatObject", self._reference_clone(FloatObject(self), pdf_dest, force_duplicate), ) def hash_bin(self) -> int: """ Used to detect modified object. Returns: Hash considering type and value. """ return hash((self.__class__, self.as_numeric)) def myrepr(self) -> str: if self == 0: return "0.0" nb = FLOAT_WRITE_PRECISION - int(log10(abs(self))) return f"{self:.{max(1, nb)}f}".rstrip("0").rstrip(".") def __repr__(self) -> str: return self.myrepr() # repr(float(self)) def as_numeric(self) -> float: return float(self) def write_to_stream( self, stream: StreamType, encryption_key: Union[None, str, bytes] = None ) -> None: if encryption_key is not None: # deprecated deprecation_no_replacement( "the encryption_key parameter of write_to_stream", "5.0.0" ) stream.write(self.myrepr().encode("utf8")) class NumberObject(int, PdfObject): NumberPattern = re.compile(b"[^+-.0-9]") def __new__(cls, value: Any) -> "NumberObject": try: return int.__new__(cls, int(value)) except ValueError: logger_warning(f"NumberObject({value}) invalid; use 0 instead", __name__) return int.__new__(cls, 0) def clone( self, pdf_dest: Any, force_duplicate: bool = False, ignore_fields: Optional[Sequence[Union[str, int]]] = (), ) -> "NumberObject": """Clone object into pdf_dest.""" return cast( "NumberObject", self._reference_clone(NumberObject(self), pdf_dest, force_duplicate), ) def hash_bin(self) -> int: """ Used to detect modified object. Returns: Hash considering type and value. """ return hash((self.__class__, self.as_numeric())) def as_numeric(self) -> int: return int(repr(self).encode("utf8")) def write_to_stream( self, stream: StreamType, encryption_key: Union[None, str, bytes] = None ) -> None: if encryption_key is not None: # deprecated deprecation_no_replacement( "the encryption_key parameter of write_to_stream", "5.0.0" ) stream.write(repr(self).encode("utf8")) @staticmethod def read_from_stream(stream: StreamType) -> Union["NumberObject", "FloatObject"]: num = read_until_regex(stream, NumberObject.NumberPattern) if b"." in num: return FloatObject(num) return NumberObject(num) class ByteStringObject(bytes, PdfObject): """ Represents a string object where the text encoding could not be determined. This occurs quite often, as the PDF spec doesn't provide an alternate way to represent strings -- for example, the encryption data stored in files (like /O) is clearly not text, but is still stored in a "String" object. """ def clone( self, pdf_dest: Any, force_duplicate: bool = False, ignore_fields: Optional[Sequence[Union[str, int]]] = (), ) -> "ByteStringObject": """Clone object into pdf_dest.""" return cast( "ByteStringObject", self._reference_clone( ByteStringObject(bytes(self)), pdf_dest, force_duplicate ), ) def hash_bin(self) -> int: """ Used to detect modified object. Returns: Hash considering type and value. """ return hash((self.__class__, bytes(self))) @property def original_bytes(self) -> bytes: """For compatibility with TextStringObject.original_bytes.""" return self def write_to_stream( self, stream: StreamType, encryption_key: Union[None, str, bytes] = None ) -> None: if encryption_key is not None: # deprecated deprecation_no_replacement( "the encryption_key parameter of write_to_stream", "5.0.0" ) stream.write(b"<") stream.write(binascii.hexlify(self)) stream.write(b">") def __str__(self) -> str: charset_to_try = ["utf-16", *list(NameObject.CHARSETS)] for enc in charset_to_try: try: return self.decode(enc) except UnicodeDecodeError: pass raise PdfReadError("Cannot decode ByteStringObject.") class TextStringObject(str, PdfObject): # noqa: SLOT000 """ A string object that has been decoded into a real unicode string. If read from a PDF document, this string appeared to match the PDFDocEncoding, or contained a UTF-16BE BOM mark to cause UTF-16 decoding to occur. """ autodetect_pdfdocencoding: bool autodetect_utf16: bool utf16_bom: bytes _original_bytes: Optional[bytes] = None def __new__(cls, value: Any) -> "TextStringObject": org = None if isinstance(value, bytes): org = value value = value.decode("charmap") o = str.__new__(cls, value) o._original_bytes = org o.autodetect_utf16 = False o.autodetect_pdfdocencoding = False o.utf16_bom = b"" if o.startswith(("\xfe\xff", "\xff\xfe")): assert org is not None, "mypy" try: o = str.__new__(cls, org.decode("utf-16")) except UnicodeDecodeError as exc: logger_warning( f"{exc!s}\ninitial string:{exc.object!r}", __name__, ) o = str.__new__(cls, exc.object[: exc.start].decode("utf-16")) o._original_bytes = org o.autodetect_utf16 = True o.utf16_bom = org[:2] else: try: encode_pdfdocencoding(o) o.autodetect_pdfdocencoding = True except UnicodeEncodeError: o.autodetect_utf16 = True o.utf16_bom = codecs.BOM_UTF16_BE return o def clone( self, pdf_dest: Any, force_duplicate: bool = False, ignore_fields: Optional[Sequence[Union[str, int]]] = (), ) -> "TextStringObject": """Clone object into pdf_dest.""" obj = TextStringObject(self) obj._original_bytes = self._original_bytes obj.autodetect_pdfdocencoding = self.autodetect_pdfdocencoding obj.autodetect_utf16 = self.autodetect_utf16 obj.utf16_bom = self.utf16_bom return cast( "TextStringObject", self._reference_clone(obj, pdf_dest, force_duplicate) ) def hash_bin(self) -> int: """ Used to detect modified object. Returns: Hash considering type and value. """ return hash((self.__class__, self.original_bytes)) @property def original_bytes(self) -> bytes: """ It is occasionally possible that a text string object gets created where a byte string object was expected due to the autodetection mechanism -- if that occurs, this "original_bytes" property can be used to back-calculate what the original encoded bytes were. """ if self._original_bytes is not None: return self._original_bytes return self.get_original_bytes() def get_original_bytes(self) -> bytes: # We're a text string object, but the library is trying to get our raw # bytes. This can happen if we auto-detected this string as text, but # we were wrong. It's pretty common. Return the original bytes that # would have been used to create this object, based upon the autodetect # method. if self.autodetect_utf16: if self.utf16_bom == codecs.BOM_UTF16_LE: return codecs.BOM_UTF16_LE + self.encode("utf-16le") if self.utf16_bom == codecs.BOM_UTF16_BE: return codecs.BOM_UTF16_BE + self.encode("utf-16be") return self.encode("utf-16be") if self.autodetect_pdfdocencoding: return encode_pdfdocencoding(self) raise Exception("no information about original bytes") # pragma: no cover def get_encoded_bytes(self) -> bytes: # Try to write the string out as a PDFDocEncoding encoded string. It's # nicer to look at in the PDF file. Sadly, we take a performance hit # here for trying... try: if self._original_bytes is not None: return self._original_bytes if self.autodetect_utf16: raise UnicodeEncodeError("", "forced", -1, -1, "") bytearr = encode_pdfdocencoding(self) except UnicodeEncodeError: if self.utf16_bom == codecs.BOM_UTF16_LE: bytearr = codecs.BOM_UTF16_LE + self.encode("utf-16le") elif self.utf16_bom == codecs.BOM_UTF16_BE: bytearr = codecs.BOM_UTF16_BE + self.encode("utf-16be") else: bytearr = self.encode("utf-16be") return bytearr def write_to_stream( self, stream: StreamType, encryption_key: Union[None, str, bytes] = None ) -> None: if encryption_key is not None: # deprecated deprecation_no_replacement( "the encryption_key parameter of write_to_stream", "5.0.0" ) bytearr = self.get_encoded_bytes() stream.write(b"(") for c_ in iter_unpack("c", bytearr): c = cast(bytes, c_[0]) if not c.isalnum() and c != b" ": # This: # stream.write(rf"\{c:0>3o}".encode()) # gives # https://github.com/davidhalter/parso/issues/207 stream.write(b"\\%03o" % ord(c)) else: stream.write(c) stream.write(b")") class NameObject(str, PdfObject): # noqa: SLOT000 delimiter_pattern = re.compile(rb"\s+|[\(\)<>\[\]{}/%]") prefix = b"/" renumber_table: ClassVar[dict[str, bytes]] = { **{chr(i): f"#{i:02X}".encode() for i in b"#()<>[]{}/%"}, **{chr(i): f"#{i:02X}".encode() for i in range(33)}, } def clone( self, pdf_dest: Any, force_duplicate: bool = False, ignore_fields: Optional[Sequence[Union[str, int]]] = (), ) -> "NameObject": """Clone object into pdf_dest.""" return cast( "NameObject", self._reference_clone(NameObject(self), pdf_dest, force_duplicate), ) def hash_bin(self) -> int: """ Used to detect modified object. Returns: Hash considering type and value. """ return hash((self.__class__, self)) def write_to_stream( self, stream: StreamType, encryption_key: Union[None, str, bytes] = None ) -> None: if encryption_key is not None: # deprecated deprecation_no_replacement( "the encryption_key parameter of write_to_stream", "5.0.0" ) stream.write(self.renumber()) def renumber(self) -> bytes: out = self[0].encode("utf-8") if out != b"/": deprecation_no_replacement( f"Incorrect first char in NameObject, should start with '/': ({self})", "5.0.0", ) for c in self[1:]: if c > "~": for x in c.encode("utf-8"): out += f"#{x:02X}".encode() else: try: out += self.renumber_table[c] except KeyError: out += c.encode("utf-8") return out def _sanitize(self) -> "NameObject": """ Sanitize the NameObject's name to be a valid PDF name part (alphanumeric, underscore, hyphen). The _sanitize method replaces spaces and any non-alphanumeric/non-underscore/non-hyphen with underscores. Returns: NameObject with sanitized name. """ name = str(self).removeprefix("/") name = re.sub(r"\ ", "_", name) name = re.sub(r"[^a-zA-Z0-9_-]", "_", name) return NameObject("/" + name) @classproperty def surfix(cls) -> bytes: # noqa: N805 deprecation_with_replacement("surfix", "prefix", "5.0.0") return b"/" @staticmethod def unnumber(sin: bytes) -> bytes: i = sin.find(b"#", 0) while i >= 0: try: sin = sin[:i] + unhexlify(sin[i + 1 : i + 3]) + sin[i + 3 :] i = sin.find(b"#", i + 1) except ValueError: # if the 2 characters after # can not be converted to hex # we change nothing and carry on i = i + 1 return sin CHARSETS = ("utf-8", "gbk", "latin1") @staticmethod def read_from_stream(stream: StreamType, pdf: Any) -> "NameObject": # PdfReader name = stream.read(1) if name != NameObject.prefix: raise PdfReadError("Name read error") name += read_until_regex(stream, NameObject.delimiter_pattern) try: # Name objects should represent irregular characters # with a '#' followed by the symbol's hex number name = NameObject.unnumber(name) for enc in NameObject.CHARSETS: try: ret = name.decode(enc) return NameObject(ret) except Exception: pass raise UnicodeDecodeError("", name, 0, 0, "Code Not Found") except (UnicodeEncodeError, UnicodeDecodeError) as e: if not pdf.strict: logger_warning( f"Illegal character in NameObject ({name!r}), " "you may need to adjust NameObject.CHARSETS", __name__, ) return NameObject(name.decode("charmap")) raise PdfReadError( f"Illegal character in NameObject ({name!r}). " "You may need to adjust NameObject.CHARSETS.", ) from e def encode_pdfdocencoding(unicode_string: str) -> bytes: try: return bytes([_pdfdoc_encoding_rev[k] for k in unicode_string]) except KeyError: raise UnicodeEncodeError( "pdfdocencoding", unicode_string, -1, -1, "does not exist in translation table", ) def is_null_or_none(x: Any) -> TypeGuard[Union[None, NullObject, IndirectObject]]: """ Returns: True if x is None or NullObject. """ return x is None or ( isinstance(x, PdfObject) and (x.get_object() is None or isinstance(x.get_object(), NullObject)) ) pypdf-6.1.2/pypdf/generic/_data_structures.py000066400000000000000000001733571507516550200213530ustar00rootroot00000000000000# Copyright (c) 2006, Mathieu Fenniak # All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. __author__ = "Mathieu Fenniak" __author_email__ = "biziqe@mathieu.fenniak.net" import logging import re import sys from collections.abc import Iterable, Sequence from io import BytesIO from math import ceil from typing import ( Any, Callable, Optional, Union, cast, ) from .._protocols import PdfReaderProtocol, PdfWriterProtocol, XmpInformationProtocol from .._utils import ( WHITESPACES, StreamType, deprecation_no_replacement, logger_warning, read_non_whitespace, read_until_regex, read_until_whitespace, skip_over_comment, ) from ..constants import ( CheckboxRadioButtonAttributes, FieldDictionaryAttributes, OutlineFontFlag, ) from ..constants import FilterTypes as FT from ..constants import StreamAttributes as SA from ..constants import TypArguments as TA from ..constants import TypFitArguments as TF from ..errors import STREAM_TRUNCATED_PREMATURELY, PdfReadError, PdfStreamError from ._base import ( BooleanObject, ByteStringObject, FloatObject, IndirectObject, NameObject, NullObject, NumberObject, PdfObject, TextStringObject, is_null_or_none, ) from ._fit import Fit from ._image_inline import ( extract_inline_A85, extract_inline_AHx, extract_inline_DCT, extract_inline_default, extract_inline_RL, ) from ._utils import read_hex_string_from_stream, read_string_from_stream if sys.version_info >= (3, 11): from typing import Self else: from typing_extensions import Self logger = logging.getLogger(__name__) IndirectPattern = re.compile(rb"[+-]?(\d+)\s+(\d+)\s+R[^a-zA-Z]") class ArrayObject(list[Any], PdfObject): def replicate( self, pdf_dest: PdfWriterProtocol, ) -> "ArrayObject": arr = cast( "ArrayObject", self._reference_clone(ArrayObject(), pdf_dest, False), ) for data in self: if hasattr(data, "replicate"): arr.append(data.replicate(pdf_dest)) else: arr.append(data) return arr def clone( self, pdf_dest: PdfWriterProtocol, force_duplicate: bool = False, ignore_fields: Optional[Sequence[Union[str, int]]] = (), ) -> "ArrayObject": """Clone object into pdf_dest.""" try: if self.indirect_reference.pdf == pdf_dest and not force_duplicate: # type: ignore return self except Exception: pass arr = cast( "ArrayObject", self._reference_clone(ArrayObject(), pdf_dest, force_duplicate), ) for data in self: if isinstance(data, StreamObject): dup = data._reference_clone( data.clone(pdf_dest, force_duplicate, ignore_fields), pdf_dest, force_duplicate, ) arr.append(dup.indirect_reference) elif hasattr(data, "clone"): arr.append(data.clone(pdf_dest, force_duplicate, ignore_fields)) else: arr.append(data) return arr def hash_bin(self) -> int: """ Used to detect modified object. Returns: Hash considering type and value. """ return hash((self.__class__, tuple(x.hash_bin() for x in self))) def items(self) -> Iterable[Any]: """Emulate DictionaryObject.items for a list (index, object).""" return enumerate(self) def _to_lst(self, lst: Any) -> list[Any]: # Convert to list, internal if isinstance(lst, (list, tuple, set)): pass elif isinstance(lst, PdfObject): lst = [lst] elif isinstance(lst, str): if lst[0] == "/": lst = [NameObject(lst)] else: lst = [TextStringObject(lst)] elif isinstance(lst, bytes): lst = [ByteStringObject(lst)] else: # for numbers,... lst = [lst] return lst def __add__(self, lst: Any) -> "ArrayObject": """ Allow extension by adding list or add one element only Args: lst: any list, tuples are extended the list. other types(numbers,...) will be appended. if str is passed it will be converted into TextStringObject or NameObject (if starting with "/") if bytes is passed it will be converted into ByteStringObject Returns: ArrayObject with all elements """ temp = ArrayObject(self) temp.extend(self._to_lst(lst)) return temp def __iadd__(self, lst: Any) -> Self: """ Allow extension by adding list or add one element only Args: lst: any list, tuples are extended the list. other types(numbers,...) will be appended. if str is passed it will be converted into TextStringObject or NameObject (if starting with "/") if bytes is passed it will be converted into ByteStringObject """ self.extend(self._to_lst(lst)) return self def __isub__(self, lst: Any) -> Self: """Allow to remove items""" for x in self._to_lst(lst): try: index = self.index(x) del self[index] except ValueError: pass return self def write_to_stream( self, stream: StreamType, encryption_key: Union[None, str, bytes] = None ) -> None: if encryption_key is not None: # deprecated deprecation_no_replacement( "the encryption_key parameter of write_to_stream", "5.0.0" ) stream.write(b"[") for data in self: stream.write(b" ") data.write_to_stream(stream) stream.write(b" ]") @staticmethod def read_from_stream( stream: StreamType, pdf: Optional[PdfReaderProtocol], forced_encoding: Union[None, str, list[str], dict[int, str]] = None, ) -> "ArrayObject": arr = ArrayObject() tmp = stream.read(1) if tmp != b"[": raise PdfReadError("Could not read array") while True: # skip leading whitespace tok = stream.read(1) while tok.isspace(): tok = stream.read(1) if tok == b"": break if tok == b"%": stream.seek(-1, 1) skip_over_comment(stream) continue stream.seek(-1, 1) # check for array ending peek_ahead = stream.read(1) if peek_ahead == b"]": break stream.seek(-1, 1) # read and append object arr.append(read_object(stream, pdf, forced_encoding)) return arr class DictionaryObject(dict[Any, Any], PdfObject): def replicate( self, pdf_dest: PdfWriterProtocol, ) -> "DictionaryObject": d__ = cast( "DictionaryObject", self._reference_clone(self.__class__(), pdf_dest, False), ) for k, v in self.items(): d__[k.replicate(pdf_dest)] = ( v.replicate(pdf_dest) if hasattr(v, "replicate") else v ) return d__ def clone( self, pdf_dest: PdfWriterProtocol, force_duplicate: bool = False, ignore_fields: Optional[Sequence[Union[str, int]]] = (), ) -> "DictionaryObject": """Clone object into pdf_dest.""" try: if self.indirect_reference.pdf == pdf_dest and not force_duplicate: # type: ignore return self except Exception: pass visited: set[tuple[int, int]] = set() # (idnum, generation) d__ = cast( "DictionaryObject", self._reference_clone(self.__class__(), pdf_dest, force_duplicate), ) if ignore_fields is None: ignore_fields = [] if len(d__.keys()) == 0: d__._clone(self, pdf_dest, force_duplicate, ignore_fields, visited) return d__ def _clone( self, src: "DictionaryObject", pdf_dest: PdfWriterProtocol, force_duplicate: bool, ignore_fields: Optional[Sequence[Union[str, int]]], visited: set[tuple[int, int]], # (idnum, generation) ) -> None: """ Update the object from src. Args: src: "DictionaryObject": pdf_dest: force_duplicate: ignore_fields: """ # First we remove the ignore_fields # that are for a limited number of levels assert ignore_fields is not None ignore_fields = list(ignore_fields) x = 0 while x < len(ignore_fields): if isinstance(ignore_fields[x], int): if cast(int, ignore_fields[x]) <= 0: del ignore_fields[x] del ignore_fields[x] continue ignore_fields[x] -= 1 # type:ignore x += 1 # Check if this is a chain list, we need to loop to prevent recur if any( field not in ignore_fields and field in src and isinstance(src.raw_get(field), IndirectObject) and isinstance(src[field], DictionaryObject) and ( src.get("/Type", None) is None or cast(DictionaryObject, src[field]).get("/Type", None) is None or src.get("/Type", None) == cast(DictionaryObject, src[field]).get("/Type", None) ) for field in ["/Next", "/Prev", "/N", "/V"] ): ignore_fields = list(ignore_fields) for lst in (("/Next", "/Prev"), ("/N", "/V")): for k in lst: objs = [] if ( k in src and k not in self and isinstance(src.raw_get(k), IndirectObject) and isinstance(src[k], DictionaryObject) # If need to go further the idea is to check # that the types are the same and ( src.get("/Type", None) is None or cast(DictionaryObject, src[k]).get("/Type", None) is None or src.get("/Type", None) == cast(DictionaryObject, src[k]).get("/Type", None) ) ): cur_obj: Optional[DictionaryObject] = cast( "DictionaryObject", src[k] ) prev_obj: Optional[DictionaryObject] = self while cur_obj is not None: clon = cast( "DictionaryObject", cur_obj._reference_clone( cur_obj.__class__(), pdf_dest, force_duplicate ), ) # Check to see if we've previously processed our item if clon.indirect_reference is not None: idnum = clon.indirect_reference.idnum generation = clon.indirect_reference.generation if (idnum, generation) in visited: cur_obj = None break visited.add((idnum, generation)) objs.append((cur_obj, clon)) assert prev_obj is not None prev_obj[NameObject(k)] = clon.indirect_reference prev_obj = clon try: if cur_obj == src: cur_obj = None else: cur_obj = cast("DictionaryObject", cur_obj[k]) except Exception: cur_obj = None for s, c in objs: c._clone( s, pdf_dest, force_duplicate, ignore_fields, visited ) for k, v in src.items(): if k not in ignore_fields: if isinstance(v, StreamObject): if not hasattr(v, "indirect_reference"): v.indirect_reference = None vv = v.clone(pdf_dest, force_duplicate, ignore_fields) assert vv.indirect_reference is not None self[k.clone(pdf_dest)] = vv.indirect_reference elif k not in self: self[NameObject(k)] = ( v.clone(pdf_dest, force_duplicate, ignore_fields) if hasattr(v, "clone") else v ) def hash_bin(self) -> int: """ Used to detect modified object. Returns: Hash considering type and value. """ return hash( (self.__class__, tuple(((k, v.hash_bin()) for k, v in self.items()))) ) def raw_get(self, key: Any) -> Any: return dict.__getitem__(self, key) def get_inherited(self, key: str, default: Any = None) -> Any: """ Returns the value of a key or from the parent if not found. If not found returns default. Args: key: string identifying the field to return default: default value to return Returns: Current key or inherited one, otherwise default value. """ if key in self: return self[key] try: if "/Parent" not in self: return default raise KeyError("Not present") except KeyError: return cast("DictionaryObject", self["/Parent"].get_object()).get_inherited( key, default ) def __setitem__(self, key: Any, value: Any) -> Any: if not isinstance(key, PdfObject): raise ValueError("Key must be a PdfObject") if not isinstance(value, PdfObject): raise ValueError("Value must be a PdfObject") return dict.__setitem__(self, key, value) def setdefault(self, key: Any, value: Optional[Any] = None) -> Any: if not isinstance(key, PdfObject): raise ValueError("Key must be a PdfObject") if not isinstance(value, PdfObject): raise ValueError("Value must be a PdfObject") return dict.setdefault(self, key, value) def __getitem__(self, key: Any) -> PdfObject: return dict.__getitem__(self, key).get_object() @property def xmp_metadata(self) -> Optional[XmpInformationProtocol]: """ Retrieve XMP (Extensible Metadata Platform) data relevant to this object, if available. See Table 347 — Additional entries in a metadata stream dictionary. Returns: Returns a :class:`~pypdf.xmp.XmpInformation` instance that can be used to access XMP metadata from the document. Can also return None if no metadata was found on the document root. """ from ..xmp import XmpInformation # noqa: PLC0415 metadata = self.get("/Metadata", None) if is_null_or_none(metadata): return None assert metadata is not None, "mypy" metadata = metadata.get_object() return XmpInformation(metadata) def write_to_stream( self, stream: StreamType, encryption_key: Union[None, str, bytes] = None ) -> None: if encryption_key is not None: # deprecated deprecation_no_replacement( "the encryption_key parameter of write_to_stream", "5.0.0" ) stream.write(b"<<\n") for key, value in self.items(): if len(key) > 2 and key[1] == "%" and key[-1] == "%": continue key.write_to_stream(stream, encryption_key) stream.write(b" ") value.write_to_stream(stream) stream.write(b"\n") stream.write(b">>") @staticmethod def read_from_stream( stream: StreamType, pdf: Optional[PdfReaderProtocol], forced_encoding: Union[None, str, list[str], dict[int, str]] = None, ) -> "DictionaryObject": def get_next_obj_pos( p: int, p1: int, rem_gens: list[int], pdf: PdfReaderProtocol ) -> int: out = p1 for gen in rem_gens: loc = pdf.xref[gen] try: values = [x for x in loc.values() if p < x <= p1] if values: out = min(out, *values) except ValueError: pass return out def read_unsized_from_stream( stream: StreamType, pdf: PdfReaderProtocol ) -> bytes: # we are just pointing at beginning of the stream eon = get_next_obj_pos(stream.tell(), 2**32, list(pdf.xref), pdf) - 1 curr = stream.tell() rw = stream.read(eon - stream.tell()) p = rw.find(b"endstream") if p < 0: raise PdfReadError( f"Unable to find 'endstream' marker for obj starting at {curr}." ) stream.seek(curr + p + 9) return rw[: p - 1] tmp = stream.read(2) if tmp != b"<<": raise PdfReadError( f"Dictionary read error at byte {hex(stream.tell())}: " "stream must begin with '<<'" ) data: dict[Any, Any] = {} while True: tok = read_non_whitespace(stream) if tok == b"\x00": continue if tok == b"%": stream.seek(-1, 1) skip_over_comment(stream) continue if not tok: raise PdfStreamError(STREAM_TRUNCATED_PREMATURELY) if tok == b">": stream.read(1) break stream.seek(-1, 1) try: try: key = read_object(stream, pdf) if isinstance(key, NullObject): break if not isinstance(key, NameObject): raise PdfReadError( f"Expecting a NameObject for key but found {key!r}" ) except PdfReadError as exc: if pdf is not None and pdf.strict: raise logger_warning(exc.__repr__(), __name__) continue tok = read_non_whitespace(stream) stream.seek(-1, 1) value = read_object(stream, pdf, forced_encoding) except Exception as exc: if pdf is not None and pdf.strict: raise PdfReadError(exc.__repr__()) logger_warning(exc.__repr__(), __name__) retval = DictionaryObject() retval.update(data) return retval # return partial data if not data.get(key): data[key] = value else: # multiple definitions of key not permitted msg = ( f"Multiple definitions in dictionary at byte " f"{hex(stream.tell())} for key {key}" ) if pdf is not None and pdf.strict: raise PdfReadError(msg) logger_warning(msg, __name__) pos = stream.tell() s = read_non_whitespace(stream) if s == b"s" and stream.read(5) == b"tream": eol = stream.read(1) # Occasional PDF file output has spaces after 'stream' keyword but before EOL. # patch provided by Danial Sandler while eol == b" ": eol = stream.read(1) if eol not in (b"\n", b"\r"): raise PdfStreamError("Stream data must be followed by a newline") if eol == b"\r" and stream.read(1) != b"\n": stream.seek(-1, 1) # this is a stream object, not a dictionary if SA.LENGTH not in data: if pdf is not None and pdf.strict: raise PdfStreamError("Stream length not defined") logger_warning( f"Stream length not defined @pos={stream.tell()}", __name__ ) data[NameObject(SA.LENGTH)] = NumberObject(-1) length = data[SA.LENGTH] if isinstance(length, IndirectObject): t = stream.tell() assert pdf is not None, "mypy" length = pdf.get_object(length) stream.seek(t, 0) if length is None: # if the PDF is damaged length = -1 pstart = stream.tell() if length >= 0: data["__streamdata__"] = stream.read(length) else: data["__streamdata__"] = read_until_regex( stream, re.compile(b"endstream") ) e = read_non_whitespace(stream) ndstream = stream.read(8) if (e + ndstream) != b"endstream": # the odd PDF file has a length that is too long, so # we need to read backwards to find the "endstream" ending. # ReportLab (unknown version) generates files with this bug, # and Python users into PDF files tend to be our audience. # we need to do this to correct the streamdata and chop off # an extra character. pos = stream.tell() stream.seek(-10, 1) end = stream.read(9) if end == b"endstream": # we found it by looking back one character further. data["__streamdata__"] = data["__streamdata__"][:-1] elif pdf is not None and not pdf.strict: stream.seek(pstart, 0) data["__streamdata__"] = read_unsized_from_stream(stream, pdf) pos = stream.tell() else: stream.seek(pos, 0) raise PdfReadError( "Unable to find 'endstream' marker after stream at byte " f"{hex(stream.tell())} (nd='{ndstream!r}', end='{end!r}')." ) else: stream.seek(pos, 0) if "__streamdata__" in data: return StreamObject.initialize_from_dictionary(data) retval = DictionaryObject() retval.update(data) return retval class TreeObject(DictionaryObject): def __init__(self, dct: Optional[DictionaryObject] = None) -> None: DictionaryObject.__init__(self) if dct: self.update(dct) def has_children(self) -> bool: return "/First" in self def __iter__(self) -> Any: return self.children() def children(self) -> Iterable[Any]: if not self.has_children(): return child_ref = self[NameObject("/First")] child = child_ref.get_object() while True: yield child if child == self[NameObject("/Last")]: return child_ref = child.get(NameObject("/Next")) # type: ignore if is_null_or_none(child_ref): return child = child_ref.get_object() def add_child(self, child: Any, pdf: PdfWriterProtocol) -> None: self.insert_child(child, None, pdf) def inc_parent_counter_default( self, parent: Union[None, IndirectObject, "TreeObject"], n: int ) -> None: if is_null_or_none(parent): return assert parent is not None, "mypy" parent = cast("TreeObject", parent.get_object()) if "/Count" in parent: parent[NameObject("/Count")] = NumberObject( max(0, cast(int, parent[NameObject("/Count")]) + n) ) self.inc_parent_counter_default(parent.get("/Parent", None), n) def inc_parent_counter_outline( self, parent: Union[None, IndirectObject, "TreeObject"], n: int ) -> None: if is_null_or_none(parent): return assert parent is not None, "mypy" parent = cast("TreeObject", parent.get_object()) # BooleanObject requires comparison with == not is opn = parent.get("/%is_open%", True) == True # noqa: E712 c = cast(int, parent.get("/Count", 0)) if c < 0: c = abs(c) parent[NameObject("/Count")] = NumberObject((c + n) * (1 if opn else -1)) if not opn: return self.inc_parent_counter_outline(parent.get("/Parent", None), n) def insert_child( self, child: Any, before: Any, pdf: PdfWriterProtocol, inc_parent_counter: Optional[Callable[..., Any]] = None, ) -> IndirectObject: if inc_parent_counter is None: inc_parent_counter = self.inc_parent_counter_default child_obj = child.get_object() child = child.indirect_reference # get_reference(child_obj) prev: Optional[DictionaryObject] if "/First" not in self: # no child yet self[NameObject("/First")] = child self[NameObject("/Count")] = NumberObject(0) self[NameObject("/Last")] = child child_obj[NameObject("/Parent")] = self.indirect_reference inc_parent_counter(self, child_obj.get("/Count", 1)) if "/Next" in child_obj: del child_obj["/Next"] if "/Prev" in child_obj: del child_obj["/Prev"] return child prev = cast("DictionaryObject", self["/Last"]) while prev.indirect_reference != before: if "/Next" in prev: prev = cast("TreeObject", prev["/Next"]) else: # append at the end prev[NameObject("/Next")] = cast("TreeObject", child) child_obj[NameObject("/Prev")] = prev.indirect_reference child_obj[NameObject("/Parent")] = self.indirect_reference if "/Next" in child_obj: del child_obj["/Next"] self[NameObject("/Last")] = child inc_parent_counter(self, child_obj.get("/Count", 1)) return child try: # insert as first or in the middle assert isinstance(prev["/Prev"], DictionaryObject) prev["/Prev"][NameObject("/Next")] = child child_obj[NameObject("/Prev")] = prev["/Prev"] except Exception: # it means we are inserting in first position del child_obj["/Next"] child_obj[NameObject("/Next")] = prev prev[NameObject("/Prev")] = child child_obj[NameObject("/Parent")] = self.indirect_reference inc_parent_counter(self, child_obj.get("/Count", 1)) return child def _remove_node_from_tree( self, prev: Any, prev_ref: Any, cur: Any, last: Any ) -> None: """ Adjust the pointers of the linked list and tree node count. Args: prev: prev_ref: cur: last: """ next_ref = cur.get(NameObject("/Next"), None) if prev is None: if next_ref: # Removing first tree node next_obj = next_ref.get_object() del next_obj[NameObject("/Prev")] self[NameObject("/First")] = next_ref self[NameObject("/Count")] = NumberObject( self[NameObject("/Count")] - 1 # type: ignore ) else: # Removing only tree node self[NameObject("/Count")] = NumberObject(0) del self[NameObject("/First")] if NameObject("/Last") in self: del self[NameObject("/Last")] else: if next_ref: # Removing middle tree node next_obj = next_ref.get_object() next_obj[NameObject("/Prev")] = prev_ref prev[NameObject("/Next")] = next_ref else: # Removing last tree node assert cur == last del prev[NameObject("/Next")] self[NameObject("/Last")] = prev_ref self[NameObject("/Count")] = NumberObject(self[NameObject("/Count")] - 1) # type: ignore def remove_child(self, child: Any) -> None: child_obj = child.get_object() child = child_obj.indirect_reference if NameObject("/Parent") not in child_obj: raise ValueError("Removed child does not appear to be a tree item") if child_obj[NameObject("/Parent")] != self: raise ValueError("Removed child is not a member of this tree") found = False prev_ref = None prev = None cur_ref: Optional[Any] = self[NameObject("/First")] cur: Optional[dict[str, Any]] = cur_ref.get_object() # type: ignore last_ref = self[NameObject("/Last")] last = last_ref.get_object() while cur is not None: if cur == child_obj: self._remove_node_from_tree(prev, prev_ref, cur, last) found = True break # Go to the next node prev_ref = cur_ref prev = cur if NameObject("/Next") in cur: cur_ref = cur[NameObject("/Next")] cur = cur_ref.get_object() else: cur_ref = None cur = None if not found: raise ValueError("Removal couldn't find item in tree") _reset_node_tree_relationship(child_obj) def remove_from_tree(self) -> None: """Remove the object from the tree it is in.""" if NameObject("/Parent") not in self: raise ValueError("Removed child does not appear to be a tree item") cast("TreeObject", self["/Parent"]).remove_child(self) def empty_tree(self) -> None: for child in self: child_obj = child.get_object() _reset_node_tree_relationship(child_obj) if NameObject("/Count") in self: del self[NameObject("/Count")] if NameObject("/First") in self: del self[NameObject("/First")] if NameObject("/Last") in self: del self[NameObject("/Last")] def _reset_node_tree_relationship(child_obj: Any) -> None: """ Call this after a node has been removed from a tree. This resets the nodes attributes in respect to that tree. Args: child_obj: """ del child_obj[NameObject("/Parent")] if NameObject("/Next") in child_obj: del child_obj[NameObject("/Next")] if NameObject("/Prev") in child_obj: del child_obj[NameObject("/Prev")] class StreamObject(DictionaryObject): def __init__(self) -> None: self._data: bytes = b"" self.decoded_self: Optional[DecodedStreamObject] = None def replicate( self, pdf_dest: PdfWriterProtocol, ) -> "StreamObject": d__ = cast( "StreamObject", self._reference_clone(self.__class__(), pdf_dest, False), ) d__._data = self._data try: decoded_self = self.decoded_self if decoded_self is None: self.decoded_self = None else: self.decoded_self = cast( "DecodedStreamObject", decoded_self.replicate(pdf_dest) ) except Exception: pass for k, v in self.items(): d__[k.replicate(pdf_dest)] = ( v.replicate(pdf_dest) if hasattr(v, "replicate") else v ) return d__ def _clone( self, src: DictionaryObject, pdf_dest: PdfWriterProtocol, force_duplicate: bool, ignore_fields: Optional[Sequence[Union[str, int]]], visited: set[tuple[int, int]], ) -> None: """ Update the object from src. Args: src: pdf_dest: force_duplicate: ignore_fields: """ self._data = cast("StreamObject", src)._data try: decoded_self = cast("StreamObject", src).decoded_self if decoded_self is None: self.decoded_self = None else: self.decoded_self = cast( "DecodedStreamObject", decoded_self.clone(pdf_dest, force_duplicate, ignore_fields), ) except Exception: pass super()._clone(src, pdf_dest, force_duplicate, ignore_fields, visited) def hash_bin(self) -> int: """ Used to detect modified object. Returns: Hash considering type and value. """ # Use _data to prevent errors on non-decoded streams. return hash((super().hash_bin(), self._data)) def get_data(self) -> bytes: return self._data def set_data(self, data: bytes) -> None: self._data = data def hash_value_data(self) -> bytes: data = super().hash_value_data() data += self.get_data() return data def write_to_stream( self, stream: StreamType, encryption_key: Union[None, str, bytes] = None ) -> None: if encryption_key is not None: # deprecated deprecation_no_replacement( "the encryption_key parameter of write_to_stream", "5.0.0" ) self[NameObject(SA.LENGTH)] = NumberObject(len(self._data)) DictionaryObject.write_to_stream(self, stream) del self[SA.LENGTH] stream.write(b"\nstream\n") stream.write(self._data) stream.write(b"\nendstream") @staticmethod def initialize_from_dictionary( data: dict[str, Any] ) -> Union["EncodedStreamObject", "DecodedStreamObject"]: retval: Union[EncodedStreamObject, DecodedStreamObject] if SA.FILTER in data: retval = EncodedStreamObject() else: retval = DecodedStreamObject() retval._data = data["__streamdata__"] del data["__streamdata__"] if SA.LENGTH in data: del data[SA.LENGTH] retval.update(data) return retval def flate_encode(self, level: int = -1) -> "EncodedStreamObject": from ..filters import FlateDecode # noqa: PLC0415 if SA.FILTER in self: f = self[SA.FILTER] if isinstance(f, ArrayObject): f = ArrayObject([NameObject(FT.FLATE_DECODE), *f]) try: params = ArrayObject( [NullObject(), *self.get(SA.DECODE_PARMS, ArrayObject())] ) except TypeError: # case of error where the * operator is not working (not an array params = ArrayObject( [NullObject(), self.get(SA.DECODE_PARMS, ArrayObject())] ) else: f = ArrayObject([NameObject(FT.FLATE_DECODE), f]) params = ArrayObject( [NullObject(), self.get(SA.DECODE_PARMS, NullObject())] ) else: f = NameObject(FT.FLATE_DECODE) params = None retval = EncodedStreamObject() retval.update(self) retval[NameObject(SA.FILTER)] = f if params is not None: retval[NameObject(SA.DECODE_PARMS)] = params retval._data = FlateDecode.encode(self._data, level) return retval def decode_as_image(self) -> Any: """ Try to decode the stream object as an image Returns: a PIL image if proper decoding has been found Raises: Exception: Errors during decoding will be reported. It is recommended to catch exceptions to prevent stops in your program. """ from ..filters import _xobj_to_image # noqa: PLC0415 if self.get("/Subtype", "") != "/Image": try: msg = f"{self.indirect_reference} does not seem to be an Image" # pragma: no cover except AttributeError: msg = f"{self.__repr__()} object does not seem to be an Image" # pragma: no cover logger_warning(msg, __name__) extension, _, img = _xobj_to_image(self) if extension is None: return None # pragma: no cover return img class DecodedStreamObject(StreamObject): pass class EncodedStreamObject(StreamObject): def __init__(self) -> None: self.decoded_self: Optional[DecodedStreamObject] = None # This overrides the parent method def get_data(self) -> bytes: from ..filters import decode_stream_data # noqa: PLC0415 if self.decoded_self is not None: # Cached version of decoded object return self.decoded_self.get_data() # Create decoded object decoded = DecodedStreamObject() decoded.set_data(decode_stream_data(self)) for key, value in self.items(): if key not in (SA.LENGTH, SA.FILTER, SA.DECODE_PARMS): decoded[key] = value self.decoded_self = decoded return decoded.get_data() # This overrides the parent method: def set_data(self, data: bytes) -> None: from ..filters import FlateDecode # noqa: PLC0415 if self.get(SA.FILTER, "") in (FT.FLATE_DECODE, [FT.FLATE_DECODE]): if not isinstance(data, bytes): raise TypeError("Data must be bytes") if self.decoded_self is None: self.get_data() # to create self.decoded_self assert self.decoded_self is not None, "mypy" self.decoded_self.set_data(data) super().set_data(FlateDecode.encode(data)) else: raise PdfReadError( "Streams encoded with a filter different from FlateDecode are not supported" ) class ContentStream(DecodedStreamObject): """ In order to be fast, this data structure can contain either: * raw data in ._data * parsed stream operations in ._operations. At any time, ContentStream object can either have both of those fields defined, or one field defined and the other set to None. These fields are "rebuilt" lazily, when accessed: * when .get_data() is called, if ._data is None, it is rebuilt from ._operations. * when .operations is called, if ._operations is None, it is rebuilt from ._data. Conversely, these fields can be invalidated: * when .set_data() is called, ._operations is set to None. * when .operations is set, ._data is set to None. """ def __init__( self, stream: Any, pdf: Any, forced_encoding: Union[None, str, list[str], dict[int, str]] = None, ) -> None: self.pdf = pdf self._operations: list[tuple[Any, bytes]] = [] # stream may be a StreamObject or an ArrayObject containing # StreamObjects to be concatenated together. if stream is None: super().set_data(b"") else: stream = stream.get_object() if isinstance(stream, ArrayObject): data = b"" for s in stream: s_resolved = s.get_object() if isinstance(s_resolved, NullObject): continue if not isinstance(s_resolved, StreamObject): # No need to emit an exception here for now - the PDF structure # seems to already be broken beforehand in these cases. logger_warning( f"Expected StreamObject, got {type(s_resolved).__name__} instead. Data might be wrong.", __name__ ) else: data += s_resolved.get_data() if len(data) == 0 or data[-1] != b"\n": data += b"\n" super().set_data(bytes(data)) else: stream_data = stream.get_data() assert stream_data is not None super().set_data(stream_data) self.forced_encoding = forced_encoding def replicate( self, pdf_dest: PdfWriterProtocol, ) -> "ContentStream": d__ = cast( "ContentStream", self._reference_clone(self.__class__(None, None), pdf_dest, False), ) d__._data = self._data try: decoded_self = self.decoded_self if decoded_self is None: self.decoded_self = None else: self.decoded_self = cast( "DecodedStreamObject", decoded_self.replicate(pdf_dest) ) except Exception: pass for k, v in self.items(): d__[k.replicate(pdf_dest)] = ( v.replicate(pdf_dest) if hasattr(v, "replicate") else v ) return d__ d__.set_data(self._data) d__.pdf = pdf_dest d__._operations = list(self._operations) d__.forced_encoding = self.forced_encoding return d__ def clone( self, pdf_dest: Any, force_duplicate: bool = False, ignore_fields: Optional[Sequence[Union[str, int]]] = (), ) -> "ContentStream": """ Clone object into pdf_dest. Args: pdf_dest: force_duplicate: ignore_fields: Returns: The cloned ContentStream """ try: if self.indirect_reference.pdf == pdf_dest and not force_duplicate: # type: ignore return self except Exception: pass visited: set[tuple[int, int]] = set() d__ = cast( "ContentStream", self._reference_clone( self.__class__(None, None), pdf_dest, force_duplicate ), ) if ignore_fields is None: ignore_fields = [] d__._clone(self, pdf_dest, force_duplicate, ignore_fields, visited) return d__ def _clone( self, src: DictionaryObject, pdf_dest: PdfWriterProtocol, force_duplicate: bool, ignore_fields: Optional[Sequence[Union[str, int]]], visited: set[tuple[int, int]], ) -> None: """ Update the object from src. Args: src: pdf_dest: force_duplicate: ignore_fields: """ src_cs = cast("ContentStream", src) super().set_data(src_cs._data) self.pdf = pdf_dest self._operations = list(src_cs._operations) self.forced_encoding = src_cs.forced_encoding # no need to call DictionaryObjection or anything # like super(DictionaryObject,self)._clone(src, pdf_dest, force_duplicate, ignore_fields, visited) def _parse_content_stream(self, stream: StreamType) -> None: # 7.8.2 Content Streams stream.seek(0, 0) operands: list[Union[int, str, PdfObject]] = [] while True: peek = read_non_whitespace(stream) if peek in (b"", 0): break stream.seek(-1, 1) if peek.isalpha() or peek in (b"'", b'"'): operator = read_until_regex(stream, NameObject.delimiter_pattern) if operator == b"BI": # begin inline image - a completely different parsing # mechanism is required, of course... thanks buddy... assert operands == [] ii = self._read_inline_image(stream) self._operations.append((ii, b"INLINE IMAGE")) else: self._operations.append((operands, operator)) operands = [] elif peek == b"%": # If we encounter a comment in the content stream, we have to # handle it here. Typically, read_object will handle # encountering a comment -- but read_object assumes that # following the comment must be the object we're trying to # read. In this case, it could be an operator instead. while peek not in (b"\r", b"\n", b""): peek = stream.read(1) else: operands.append(read_object(stream, None, self.forced_encoding)) def _read_inline_image(self, stream: StreamType) -> dict[str, Any]: # begin reading just after the "BI" - begin image # first read the dictionary of settings. settings = DictionaryObject() while True: tok = read_non_whitespace(stream) stream.seek(-1, 1) if tok == b"I": # "ID" - begin of image data break key = read_object(stream, self.pdf) tok = read_non_whitespace(stream) stream.seek(-1, 1) value = read_object(stream, self.pdf) settings[key] = value # left at beginning of ID tmp = stream.read(3) assert tmp[:2] == b"ID" filtr = settings.get("/F", settings.get("/Filter", "not set")) savpos = stream.tell() if isinstance(filtr, list): filtr = filtr[0] # used forencoding if "AHx" in filtr or "ASCIIHexDecode" in filtr: data = extract_inline_AHx(stream) elif "A85" in filtr or "ASCII85Decode" in filtr: data = extract_inline_A85(stream) elif "RL" in filtr or "RunLengthDecode" in filtr: data = extract_inline_RL(stream) elif "DCT" in filtr or "DCTDecode" in filtr: data = extract_inline_DCT(stream) elif filtr == "not set": cs = settings.get("/CS", "") if isinstance(cs, list): cs = cs[0] if "RGB" in cs: lcs = 3 elif "CMYK" in cs: lcs = 4 else: bits = settings.get( "/BPC", 8 if cs in {"/I", "/G", "/Indexed", "/DeviceGray"} else -1, ) if bits > 0: lcs = bits / 8.0 else: data = extract_inline_default(stream) lcs = -1 if lcs > 0: data = stream.read( ceil(cast(int, settings["/W"]) * lcs) * cast(int, settings["/H"]) ) # Move to the `EI` if possible. ei = read_non_whitespace(stream) stream.seek(-1, 1) else: data = extract_inline_default(stream) ei = stream.read(3) stream.seek(-1, 1) if ei[:2] != b"EI" or ei[2:3] not in WHITESPACES: # Deal with wrong/missing `EI` tags. Example: Wrong dimensions specified above. stream.seek(savpos, 0) data = extract_inline_default(stream) ei = stream.read(3) stream.seek(-1, 1) if ei[:2] != b"EI" or ei[2:3] not in WHITESPACES: # pragma: no cover # Check the same condition again. This should never fail as # edge cases are covered by `extract_inline_default` above, # but check this ot make sure that we are behind the `EI` afterwards. raise PdfStreamError( f"Could not extract inline image, even using fallback. Expected 'EI', got {ei!r}" ) return {"settings": settings, "data": data} # This overrides the parent method def get_data(self) -> bytes: if not self._data: new_data = BytesIO() for operands, operator in self._operations: if operator == b"INLINE IMAGE": new_data.write(b"BI") dict_text = BytesIO() operands["settings"].write_to_stream(dict_text) new_data.write(dict_text.getvalue()[2:-2]) new_data.write(b"ID ") new_data.write(operands["data"]) new_data.write(b"EI") else: for op in operands: op.write_to_stream(new_data) new_data.write(b" ") new_data.write(operator) new_data.write(b"\n") self._data = new_data.getvalue() return self._data # This overrides the parent method def set_data(self, data: bytes) -> None: super().set_data(data) self._operations = [] @property def operations(self) -> list[tuple[Any, bytes]]: if not self._operations and self._data: self._parse_content_stream(BytesIO(self._data)) self._data = b"" return self._operations @operations.setter def operations(self, operations: list[tuple[Any, bytes]]) -> None: self._operations = operations self._data = b"" def isolate_graphics_state(self) -> None: if self._operations: self._operations.insert(0, ([], b"q")) self._operations.append(([], b"Q")) elif self._data: self._data = b"q\n" + self._data + b"\nQ\n" # This overrides the parent method def write_to_stream( self, stream: StreamType, encryption_key: Union[None, str, bytes] = None ) -> None: if not self._data and self._operations: self.get_data() # this ensures ._data is rebuilt super().write_to_stream(stream, encryption_key) def read_object( stream: StreamType, pdf: Optional[PdfReaderProtocol], forced_encoding: Union[None, str, list[str], dict[int, str]] = None, ) -> Union[PdfObject, int, str, ContentStream]: tok = stream.read(1) stream.seek(-1, 1) # reset to start if tok == b"/": return NameObject.read_from_stream(stream, pdf) if tok == b"<": # hexadecimal string OR dictionary peek = stream.read(2) stream.seek(-2, 1) # reset to start if peek == b"<<": return DictionaryObject.read_from_stream(stream, pdf, forced_encoding) return read_hex_string_from_stream(stream, forced_encoding) if tok == b"[": return ArrayObject.read_from_stream(stream, pdf, forced_encoding) if tok in (b"t", b"f"): return BooleanObject.read_from_stream(stream) if tok == b"(": return read_string_from_stream(stream, forced_encoding) if tok == b"e" and stream.read(6) == b"endobj": return NullObject() if tok == b"n": return NullObject.read_from_stream(stream) if tok == b"%": # comment skip_over_comment(stream) tok = read_non_whitespace(stream) stream.seek(-1, 1) return read_object(stream, pdf, forced_encoding) if tok in b"0123456789+-.": # number object OR indirect reference peek = stream.read(20) stream.seek(-len(peek), 1) # reset to start if IndirectPattern.match(peek) is not None: assert pdf is not None, "mypy" return IndirectObject.read_from_stream(stream, pdf) return NumberObject.read_from_stream(stream) pos = stream.tell() stream.seek(-20, 1) stream_extract = stream.read(80) stream.seek(pos) read_until_whitespace(stream) raise PdfReadError( f"Invalid Elementary Object starting with {tok!r} @{pos}: {stream_extract!r}" ) class Field(TreeObject): """ A class representing a field dictionary. This class is accessed through :meth:`get_fields()` """ def __init__(self, data: DictionaryObject) -> None: DictionaryObject.__init__(self) field_attributes = ( FieldDictionaryAttributes.attributes() + CheckboxRadioButtonAttributes.attributes() ) self.indirect_reference = data.indirect_reference for attr in field_attributes: try: self[NameObject(attr)] = data[attr] except KeyError: pass if isinstance(self.get("/V"), EncodedStreamObject): d = cast(EncodedStreamObject, self[NameObject("/V")]).get_data() if isinstance(d, bytes): d_str = d.decode() elif d is None: d_str = "" else: raise Exception("Should never happen") self[NameObject("/V")] = TextStringObject(d_str) # TABLE 8.69 Entries common to all field dictionaries @property def field_type(self) -> Optional[NameObject]: """Read-only property accessing the type of this field.""" return self.get(FieldDictionaryAttributes.FT) @property def parent(self) -> Optional[DictionaryObject]: """Read-only property accessing the parent of this field.""" return self.get(FieldDictionaryAttributes.Parent) @property def kids(self) -> Optional["ArrayObject"]: """Read-only property accessing the kids of this field.""" return self.get(FieldDictionaryAttributes.Kids) @property def name(self) -> Optional[str]: """Read-only property accessing the name of this field.""" return self.get(FieldDictionaryAttributes.T) @property def alternate_name(self) -> Optional[str]: """Read-only property accessing the alternate name of this field.""" return self.get(FieldDictionaryAttributes.TU) @property def mapping_name(self) -> Optional[str]: """ Read-only property accessing the mapping name of this field. This name is used by pypdf as a key in the dictionary returned by :meth:`get_fields()` """ return self.get(FieldDictionaryAttributes.TM) @property def flags(self) -> Optional[int]: """ Read-only property accessing the field flags, specifying various characteristics of the field (see Table 8.70 of the PDF 1.7 reference). """ return self.get(FieldDictionaryAttributes.Ff) @property def value(self) -> Optional[Any]: """ Read-only property accessing the value of this field. Format varies based on field type. """ return self.get(FieldDictionaryAttributes.V) @property def default_value(self) -> Optional[Any]: """Read-only property accessing the default value of this field.""" return self.get(FieldDictionaryAttributes.DV) @property def additional_actions(self) -> Optional[DictionaryObject]: """ Read-only property accessing the additional actions dictionary. This dictionary defines the field's behavior in response to trigger events. See Section 8.5.2 of the PDF 1.7 reference. """ return self.get(FieldDictionaryAttributes.AA) class Destination(TreeObject): """ A class representing a destination within a PDF file. See section 12.3.2 of the PDF 2.0 reference. Args: title: Title of this destination. page: Reference to the page of this destination. Should be an instance of :class:`IndirectObject`. fit: How the destination is displayed. Raises: PdfReadError: If destination type is invalid. """ node: Optional[ DictionaryObject ] = None # node provide access to the original Object def __init__( self, title: Union[str, bytes], page: Union[NumberObject, IndirectObject, NullObject, DictionaryObject], fit: Fit, ) -> None: self._filtered_children: list[Any] = [] # used in PdfWriter typ = fit.fit_type args = fit.fit_args DictionaryObject.__init__(self) self[NameObject("/Title")] = TextStringObject(title) self[NameObject("/Page")] = page self[NameObject("/Type")] = typ # from table 8.2 of the PDF 1.7 reference. if typ == "/XYZ": if len(args) < 1: # left is missing : should never occur args.append(NumberObject(0.0)) if len(args) < 2: # top is missing args.append(NumberObject(0.0)) if len(args) < 3: # zoom is missing args.append(NumberObject(0.0)) ( self[NameObject(TA.LEFT)], self[NameObject(TA.TOP)], self[NameObject("/Zoom")], ) = args elif len(args) == 0: pass elif typ == TF.FIT_R: ( self[NameObject(TA.LEFT)], self[NameObject(TA.BOTTOM)], self[NameObject(TA.RIGHT)], self[NameObject(TA.TOP)], ) = args elif typ in [TF.FIT_H, TF.FIT_BH]: try: # Prefer to be more robust not only to null parameters (self[NameObject(TA.TOP)],) = args except Exception: (self[NameObject(TA.TOP)],) = (NullObject(),) elif typ in [TF.FIT_V, TF.FIT_BV]: try: # Prefer to be more robust not only to null parameters (self[NameObject(TA.LEFT)],) = args except Exception: (self[NameObject(TA.LEFT)],) = (NullObject(),) elif typ in [TF.FIT, TF.FIT_B]: pass else: raise PdfReadError(f"Unknown Destination Type: {typ!r}") @property def dest_array(self) -> "ArrayObject": return ArrayObject( [self.raw_get("/Page"), self["/Type"]] + [ self[x] for x in ["/Left", "/Bottom", "/Right", "/Top", "/Zoom"] if x in self ] ) def write_to_stream( self, stream: StreamType, encryption_key: Union[None, str, bytes] = None ) -> None: if encryption_key is not None: # deprecated deprecation_no_replacement( "the encryption_key parameter of write_to_stream", "5.0.0" ) stream.write(b"<<\n") key = NameObject("/D") key.write_to_stream(stream) stream.write(b" ") value = self.dest_array value.write_to_stream(stream) key = NameObject("/S") key.write_to_stream(stream) stream.write(b" ") value_s = NameObject("/GoTo") value_s.write_to_stream(stream) stream.write(b"\n") stream.write(b">>") @property def title(self) -> Optional[str]: """Read-only property accessing the destination title.""" return self.get("/Title") @property def page(self) -> Optional[IndirectObject]: """Read-only property accessing the IndirectObject of the destination page.""" return self.get("/Page") @property def typ(self) -> Optional[str]: """Read-only property accessing the destination type.""" return self.get("/Type") @property def zoom(self) -> Optional[int]: """Read-only property accessing the zoom factor.""" return self.get("/Zoom", None) @property def left(self) -> Optional[FloatObject]: """Read-only property accessing the left horizontal coordinate.""" return self.get("/Left", None) @property def right(self) -> Optional[FloatObject]: """Read-only property accessing the right horizontal coordinate.""" return self.get("/Right", None) @property def top(self) -> Optional[FloatObject]: """Read-only property accessing the top vertical coordinate.""" return self.get("/Top", None) @property def bottom(self) -> Optional[FloatObject]: """Read-only property accessing the bottom vertical coordinate.""" return self.get("/Bottom", None) @property def color(self) -> Optional["ArrayObject"]: """Read-only property accessing the color in (R, G, B) with values 0.0-1.0.""" return self.get( "/C", ArrayObject([FloatObject(0), FloatObject(0), FloatObject(0)]) ) @property def font_format(self) -> Optional[OutlineFontFlag]: """ Read-only property accessing the font type. 1=italic, 2=bold, 3=both """ return self.get("/F", 0) @property def outline_count(self) -> Optional[int]: """ Read-only property accessing the outline count. positive = expanded negative = collapsed absolute value = number of visible descendants at all levels """ return self.get("/Count", None) pypdf-6.1.2/pypdf/generic/_files.py000066400000000000000000000375561507516550200172410ustar00rootroot00000000000000from __future__ import annotations import bisect from functools import cached_property from typing import TYPE_CHECKING, cast from pypdf._utils import format_iso8824_date, parse_iso8824_date from pypdf.constants import CatalogAttributes as CA from pypdf.constants import FileSpecificationDictionaryEntries from pypdf.constants import PageAttributes as PG from pypdf.errors import PdfReadError, PyPdfError from pypdf.generic import ( ArrayObject, ByteStringObject, DecodedStreamObject, DictionaryObject, NameObject, NullObject, NumberObject, StreamObject, TextStringObject, is_null_or_none, ) if TYPE_CHECKING: import datetime from collections.abc import Generator from pypdf._writer import PdfWriter class EmbeddedFile: """ Container holding the information on an embedded file. Attributes are evaluated lazily if possible. Further information on embedded files can be found in section 7.11 of the PDF 2.0 specification. """ def __init__(self, name: str, pdf_object: DictionaryObject, parent: ArrayObject | None = None) -> None: """ Args: name: The (primary) name as provided in the name tree. pdf_object: The corresponding PDF object to allow retrieving further data. parent: The parent list. """ self._name = name self.pdf_object = pdf_object self._parent = parent @property def name(self) -> str: """The (primary) name of the embedded file as provided in the name tree.""" return self._name @classmethod def _create_new(cls, writer: PdfWriter, name: str, content: str | bytes) -> EmbeddedFile: """ Create a new embedded file and add it to the PdfWriter. Args: writer: The PdfWriter instance to add the embedded file to. name: The filename to display. content: The data in the file. Returns: EmbeddedFile instance for the newly created embedded file. """ # Convert string content to bytes if needed if isinstance(content, str): content = content.encode("latin-1") # Create the file entry (the actual embedded file stream) file_entry = DecodedStreamObject() file_entry.set_data(content) file_entry.update({NameObject(PG.TYPE): NameObject("/EmbeddedFile")}) # Create the /EF entry ef_entry = DictionaryObject() ef_entry.update({NameObject("/F"): writer._add_object(file_entry)}) # Create the filespec dictionary from pypdf.generic import create_string_object # noqa: PLC0415 filespec = DictionaryObject() filespec_reference = writer._add_object(filespec) name_object = cast(TextStringObject, create_string_object(name)) filespec.update( { NameObject(PG.TYPE): NameObject("/Filespec"), NameObject(FileSpecificationDictionaryEntries.F): name_object, NameObject(FileSpecificationDictionaryEntries.EF): ef_entry, } ) # Add the name and filespec to the names array. # We use the inverse order for insertion, as this allows us to re-use the # same index. names_array = cls._get_names_array(writer) insertion_index = cls._get_insertion_index(names_array, name_object) names_array.insert(insertion_index, filespec_reference) names_array.insert(insertion_index, name_object) # Return an EmbeddedFile instance return cls(name=name, pdf_object=filespec, parent=names_array) @classmethod def _get_names_array(cls, writer: PdfWriter) -> ArrayObject: """Get the names array for embedded files, possibly creating and flattening it.""" if CA.NAMES not in writer.root_object: # Add the /Names entry to the catalog. writer.root_object[NameObject(CA.NAMES)] = writer._add_object(DictionaryObject()) names_dict = cast(DictionaryObject, writer.root_object[CA.NAMES]) if "/EmbeddedFiles" not in names_dict: # We do not yet have an entry for embedded files. Create and return it. names = ArrayObject() embedded_files_names_dictionary = DictionaryObject( {NameObject(CA.NAMES): names} ) names_dict[NameObject("/EmbeddedFiles")] = writer._add_object(embedded_files_names_dictionary) return names # We have an existing embedded files entry. embedded_files_names_tree = cast(DictionaryObject, names_dict["/EmbeddedFiles"]) if "/Names" in embedded_files_names_tree: # Simple case: We already have a flat list. return cast(ArrayObject, embedded_files_names_tree[NameObject(CA.NAMES)]) if "/Kids" not in embedded_files_names_tree: # Invalid case: This is no name tree. raise PdfReadError("Got neither Names nor Kids in embedded files tree.") # Complex case: Convert a /Kids-based name tree to a /Names-based one. # /Name-based ones are much easier to handle and allow us to simplify the # actual insertion logic by only having to consider one case. names = ArrayObject() kids = cast(ArrayObject, embedded_files_names_tree["/Kids"].get_object()) embedded_files_names_dictionary = DictionaryObject( {NameObject(CA.NAMES): names} ) names_dict[NameObject("/EmbeddedFiles")] = writer._add_object(embedded_files_names_dictionary) for kid in kids: # Write the flattened file entries. As we do not change the actual files, # this should not have any impact on references to them. # There might be further (nested) kids here. # Wait for an example before evaluating an implementation. for name in kid.get_object().get("/Names", []): names.append(name) return names @classmethod def _get_insertion_index(cls, names_array: ArrayObject, name: str) -> int: keys = [names_array[i].encode("utf-8") for i in range(0, len(names_array), 2)] name_bytes = name.encode("utf-8") start = bisect.bisect_left(keys, name_bytes) end = bisect.bisect_right(keys, name_bytes) if start != end: return end * 2 if start == 0: return 0 if start == (key_count := len(keys)): return key_count * 2 return end * 2 @property def alternative_name(self) -> str | None: """Retrieve the alternative name (file specification).""" for key in [FileSpecificationDictionaryEntries.UF, FileSpecificationDictionaryEntries.F]: # PDF 2.0 reference, table 43: # > A PDF reader shall use the value of the UF key, when present, instead of the F key. if key in self.pdf_object: value = self.pdf_object[key].get_object() if not is_null_or_none(value): return cast(str, value) return None @alternative_name.setter def alternative_name(self, value: TextStringObject | None) -> None: """Set the alternative name (file specification).""" if value is None: if FileSpecificationDictionaryEntries.UF in self.pdf_object: self.pdf_object[NameObject(FileSpecificationDictionaryEntries.UF)] = NullObject() if FileSpecificationDictionaryEntries.F in self.pdf_object: self.pdf_object[NameObject(FileSpecificationDictionaryEntries.F)] = NullObject() else: self.pdf_object[NameObject(FileSpecificationDictionaryEntries.UF)] = value self.pdf_object[NameObject(FileSpecificationDictionaryEntries.F)] = value @property def description(self) -> str | None: """Retrieve the description.""" value = self.pdf_object.get(FileSpecificationDictionaryEntries.DESC) if is_null_or_none(value): return None return value @description.setter def description(self, value: TextStringObject | None) -> None: """Set the description.""" if value is None: self.pdf_object[NameObject(FileSpecificationDictionaryEntries.DESC)] = NullObject() else: self.pdf_object[NameObject(FileSpecificationDictionaryEntries.DESC)] = value @property def associated_file_relationship(self) -> str: """Retrieve the relationship of the referring document to this embedded file.""" return self.pdf_object.get("/AFRelationship", "/Unspecified") @associated_file_relationship.setter def associated_file_relationship(self, value: NameObject) -> None: """Set the relationship of the referring document to this embedded file.""" self.pdf_object[NameObject("/AFRelationship")] = value @property def _embedded_file(self) -> StreamObject: """Retrieve the actual embedded file stream.""" if "/EF" not in self.pdf_object: raise PdfReadError(f"/EF entry not found: {self.pdf_object}") ef = cast(DictionaryObject, self.pdf_object["/EF"]) for key in [FileSpecificationDictionaryEntries.UF, FileSpecificationDictionaryEntries.F]: if key in ef: return cast(StreamObject, ef[key].get_object()) raise PdfReadError(f"No /(U)F key found in file dictionary: {ef}") @property def _params(self) -> DictionaryObject: """Retrieve the file-specific parameters.""" return self._embedded_file.get("/Params", DictionaryObject()).get_object() @cached_property def _ensure_params(self) -> DictionaryObject: """Ensure the /Params dictionary exists and return it.""" embedded_file = self._embedded_file if "/Params" not in embedded_file: embedded_file[NameObject("/Params")] = DictionaryObject() return cast(DictionaryObject, embedded_file["/Params"]) @property def subtype(self) -> str | None: """Retrieve the subtype. This is a MIME media type, prefixed by a slash.""" value = self._embedded_file.get("/Subtype") if is_null_or_none(value): return None return value @subtype.setter def subtype(self, value: NameObject | None) -> None: """Set the subtype. This should be a MIME media type, prefixed by a slash.""" embedded_file = self._embedded_file if value is None: embedded_file[NameObject("/Subtype")] = NullObject() else: embedded_file[NameObject("/Subtype")] = value @property def content(self) -> bytes: """Retrieve the actual file content.""" return self._embedded_file.get_data() @content.setter def content(self, value: str | bytes) -> None: """Set the file content.""" if isinstance(value, str): value = value.encode("latin-1") self._embedded_file.set_data(value) @property def size(self) -> int | None: """Retrieve the size of the uncompressed file in bytes.""" value = self._params.get("/Size") if is_null_or_none(value): return None return value @size.setter def size(self, value: NumberObject | None) -> None: """Set the size of the uncompressed file in bytes.""" params = self._ensure_params if value is None: params[NameObject("/Size")] = NullObject() else: params[NameObject("/Size")] = value @property def creation_date(self) -> datetime.datetime | None: """Retrieve the file creation datetime.""" return parse_iso8824_date(self._params.get("/CreationDate")) @creation_date.setter def creation_date(self, value: datetime.datetime | None) -> None: """Set the file creation datetime.""" params = self._ensure_params if value is None: params[NameObject("/CreationDate")] = NullObject() else: date_str = format_iso8824_date(value) params[NameObject("/CreationDate")] = TextStringObject(date_str) @property def modification_date(self) -> datetime.datetime | None: """Retrieve the datetime of the last file modification.""" return parse_iso8824_date(self._params.get("/ModDate")) @modification_date.setter def modification_date(self, value: datetime.datetime | None) -> None: """Set the datetime of the last file modification.""" params = self._ensure_params if value is None: params[NameObject("/ModDate")] = NullObject() else: date_str = format_iso8824_date(value) params[NameObject("/ModDate")] = TextStringObject(date_str) @property def checksum(self) -> bytes | None: """Retrieve the MD5 checksum of the (uncompressed) file.""" value = self._params.get("/CheckSum") if is_null_or_none(value): return None return value @checksum.setter def checksum(self, value: ByteStringObject | None) -> None: """Set the MD5 checksum of the (uncompressed) file.""" params = self._ensure_params if value is None: params[NameObject("/CheckSum")] = NullObject() else: params[NameObject("/CheckSum")] = value def delete(self) -> None: """Delete the file from the document.""" if not self._parent: raise PyPdfError("Parent required to delete file from document.") if self.pdf_object in self._parent: index = self._parent.index(self.pdf_object) elif ( (indirect_reference := getattr(self.pdf_object, "indirect_reference", None)) is not None and indirect_reference in self._parent ): index = self._parent.index(indirect_reference) else: raise PyPdfError("File not found in parent object.") self._parent.pop(index) # Reference. self._parent.pop(index - 1) # Name. self.pdf_object = DictionaryObject() # Invalidate. def __repr__(self) -> str: return f"<{self.__class__.__name__} name={self.name!r}>" @classmethod def _load_from_names(cls, names: ArrayObject) -> Generator[EmbeddedFile]: """ Convert the given name tree into class instances. Args: names: The name tree to load the data from. Returns: Iterable of class instances for the files found. """ # This is a name tree of the format [name_1, reference_1, name_2, reference_2, ...] for i, name in enumerate(names): if not isinstance(name, str): # Skip plain strings and retrieve them as `direct_name` by index. file_dictionary = name.get_object() direct_name = names[i - 1].get_object() yield EmbeddedFile(name=direct_name, pdf_object=file_dictionary, parent=names) @classmethod def _load(cls, catalog: DictionaryObject) -> Generator[EmbeddedFile]: """ Load the embedded files for the given document catalog. This method and its signature are considered internal API and thus not exposed publicly for now. Args: catalog: The document catalog to load from. Returns: Iterable of class instances for the files found. """ try: container = cast( DictionaryObject, cast(DictionaryObject, catalog["/Names"])["/EmbeddedFiles"], ) except KeyError: return if "/Kids" in container: for kid in cast(ArrayObject, container["/Kids"].get_object()): # There might be further (nested) kids here. # Wait for an example before evaluating an implementation. kid = kid.get_object() if "/Names" in kid: yield from cls._load_from_names(cast(ArrayObject, kid["/Names"])) if "/Names" in container: yield from cls._load_from_names(cast(ArrayObject, container["/Names"])) pypdf-6.1.2/pypdf/generic/_fit.py000066400000000000000000000126131507516550200167040ustar00rootroot00000000000000from typing import Any, Optional, Union from ._base import is_null_or_none class Fit: def __init__( self, fit_type: str, fit_args: tuple[Union[None, float, Any], ...] = () ) -> None: from ._base import FloatObject, NameObject, NullObject, NumberObject # noqa: PLC0415 self.fit_type = NameObject(fit_type) self.fit_args: list[Union[NullObject, FloatObject, NumberObject]] = [ NullObject() if is_null_or_none(a) else FloatObject(a) for a in fit_args ] @classmethod def xyz( cls, left: Optional[float] = None, top: Optional[float] = None, zoom: Optional[float] = None, ) -> "Fit": """ Display the page designated by page, with the coordinates (left, top) positioned at the upper-left corner of the window and the contents of the page magnified by the factor zoom. A null value for any of the parameters left, top, or zoom specifies that the current value of that parameter is to be retained unchanged. A zoom value of 0 has the same meaning as a null value. Args: left: top: zoom: Returns: The created fit object. """ return Fit(fit_type="/XYZ", fit_args=(left, top, zoom)) @classmethod def fit(cls) -> "Fit": """ Display the page designated by page, with its contents magnified just enough to fit the entire page within the window both horizontally and vertically. If the required horizontal and vertical magnification factors are different, use the smaller of the two, centering the page within the window in the other dimension. """ return Fit(fit_type="/Fit") @classmethod def fit_horizontally(cls, top: Optional[float] = None) -> "Fit": """ Display the page designated by page, with the vertical coordinate top positioned at the top edge of the window and the contents of the page magnified just enough to fit the entire width of the page within the window. A null value for ``top`` specifies that the current value of that parameter is to be retained unchanged. Args: top: Returns: The created fit object. """ return Fit(fit_type="/FitH", fit_args=(top,)) @classmethod def fit_vertically(cls, left: Optional[float] = None) -> "Fit": return Fit(fit_type="/FitV", fit_args=(left,)) @classmethod def fit_rectangle( cls, left: Optional[float] = None, bottom: Optional[float] = None, right: Optional[float] = None, top: Optional[float] = None, ) -> "Fit": """ Display the page designated by page, with its contents magnified just enough to fit the rectangle specified by the coordinates left, bottom, right, and top entirely within the window both horizontally and vertically. If the required horizontal and vertical magnification factors are different, use the smaller of the two, centering the rectangle within the window in the other dimension. A null value for any of the parameters may result in unpredictable behavior. Args: left: bottom: right: top: Returns: The created fit object. """ return Fit(fit_type="/FitR", fit_args=(left, bottom, right, top)) @classmethod def fit_box(cls) -> "Fit": """ Display the page designated by page, with its contents magnified just enough to fit its bounding box entirely within the window both horizontally and vertically. If the required horizontal and vertical magnification factors are different, use the smaller of the two, centering the bounding box within the window in the other dimension. """ return Fit(fit_type="/FitB") @classmethod def fit_box_horizontally(cls, top: Optional[float] = None) -> "Fit": """ Display the page designated by page, with the vertical coordinate top positioned at the top edge of the window and the contents of the page magnified just enough to fit the entire width of its bounding box within the window. A null value for top specifies that the current value of that parameter is to be retained unchanged. Args: top: Returns: The created fit object. """ return Fit(fit_type="/FitBH", fit_args=(top,)) @classmethod def fit_box_vertically(cls, left: Optional[float] = None) -> "Fit": """ Display the page designated by page, with the horizontal coordinate left positioned at the left edge of the window and the contents of the page magnified just enough to fit the entire height of its bounding box within the window. A null value for left specifies that the current value of that parameter is to be retained unchanged. Args: left: Returns: The created fit object. """ return Fit(fit_type="/FitBV", fit_args=(left,)) def __str__(self) -> str: if not self.fit_args: return f"Fit({self.fit_type})" return f"Fit({self.fit_type}, {self.fit_args})" DEFAULT_FIT = Fit.fit() pypdf-6.1.2/pypdf/generic/_image_inline.py000066400000000000000000000263261507516550200205500ustar00rootroot00000000000000# Copyright (c) 2024, pypdf contributors # All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. import logging from io import BytesIO from typing import IO from .._utils import ( WHITESPACES, WHITESPACES_AS_BYTES, StreamType, read_non_whitespace, ) from ..errors import PdfReadError logger = logging.getLogger(__name__) # An inline image should be used only for small images (4096 bytes or less), # but allow twice this for cases where this has been exceeded. BUFFER_SIZE = 8192 def extract_inline_AHx(stream: StreamType) -> bytes: """ Extract HexEncoded stream from inline image. The stream will be moved onto the EI. """ data_out: bytes = b"" # Read data until delimiter > and EI as backup. while True: data_buffered = read_non_whitespace(stream) + stream.read(BUFFER_SIZE) if not data_buffered: raise PdfReadError("Unexpected end of stream") pos_tok = data_buffered.find(b">") if pos_tok >= 0: # found > data_out += data_buffered[: pos_tok + 1] stream.seek(-len(data_buffered) + pos_tok + 1, 1) break pos_ei = data_buffered.find(b"EI") if pos_ei >= 0: # found EI stream.seek(-len(data_buffered) + pos_ei - 1, 1) c = stream.read(1) while c in WHITESPACES: stream.seek(-2, 1) c = stream.read(1) pos_ei -= 1 data_out += data_buffered[:pos_ei] break if len(data_buffered) == 2: data_out += data_buffered raise PdfReadError("Unexpected end of stream") # Neither > nor EI found data_out += data_buffered[:-2] stream.seek(-2, 1) ei_tok = read_non_whitespace(stream) ei_tok += stream.read(2) stream.seek(-3, 1) if ei_tok[:2] != b"EI" or not (ei_tok[2:3] == b"" or ei_tok[2:3] in WHITESPACES): raise PdfReadError("EI stream not found") return data_out def extract_inline_A85(stream: StreamType) -> bytes: """ Extract A85 stream from inline image. The stream will be moved onto the EI. """ data_out: bytes = b"" # Read data until delimiter ~> while True: data_buffered = read_non_whitespace(stream) + stream.read(BUFFER_SIZE) if not data_buffered: raise PdfReadError("Unexpected end of stream") pos_tok = data_buffered.find(b"~>") if pos_tok >= 0: # found! data_out += data_buffered[: pos_tok + 2] stream.seek(-len(data_buffered) + pos_tok + 2, 1) break if len(data_buffered) == 2: # end of buffer data_out += data_buffered raise PdfReadError("Unexpected end of stream") data_out += data_buffered[ :-2 ] # back by one char in case of in the middle of ~> stream.seek(-2, 1) ei_tok = read_non_whitespace(stream) ei_tok += stream.read(2) stream.seek(-3, 1) if ei_tok[:2] != b"EI" or not (ei_tok[2:3] == b"" or ei_tok[2:3] in WHITESPACES): raise PdfReadError("EI stream not found") return data_out def extract_inline_RL(stream: StreamType) -> bytes: """ Extract RL (RunLengthDecode) stream from inline image. The stream will be moved onto the EI. """ data_out: bytes = b"" # Read data until delimiter 128 while True: data_buffered = stream.read(BUFFER_SIZE) if not data_buffered: raise PdfReadError("Unexpected end of stream") pos_tok = data_buffered.find(b"\x80") if pos_tok >= 0: # found data_out += data_buffered[: pos_tok + 1] stream.seek(-len(data_buffered) + pos_tok + 1, 1) break data_out += data_buffered ei_tok = read_non_whitespace(stream) ei_tok += stream.read(2) stream.seek(-3, 1) if ei_tok[:2] != b"EI" or not (ei_tok[2:3] == b"" or ei_tok[2:3] in WHITESPACES): raise PdfReadError("EI stream not found") return data_out def extract_inline_DCT(stream: StreamType) -> bytes: """ Extract DCT (JPEG) stream from inline image. The stream will be moved onto the EI. """ data_out: bytes = b"" # Read Blocks of data (ID/Size/data) up to ID=FF/D9 # https://www.digicamsoft.com/itu/itu-t81-36.html notfirst = False while True: c = stream.read(1) if notfirst or (c == b"\xff"): data_out += c if c != b"\xff": continue notfirst = True c = stream.read(1) data_out += c if c == b"\xff": stream.seek(-1, 1) # pragma: no cover elif c == b"\x00": # stuffing pass elif c == b"\xd9": # end break elif c in ( b"\xc0\xc1\xc2\xc3\xc4\xc5\xc6\xc7\xc9\xca\xcb\xcc\xcd\xce\xcf" b"\xda\xdb\xdc\xdd\xde\xdf" b"\xe0\xe1\xe2\xe3\xe4\xe5\xe6\xe7\xe8\xe9\xea\xeb\xec\xed\xee\xef\xfe" ): c = stream.read(2) data_out += c sz = c[0] * 256 + c[1] data_out += stream.read(sz - 2) ei_tok = read_non_whitespace(stream) ei_tok += stream.read(2) stream.seek(-3, 1) if ei_tok[:2] != b"EI" or not (ei_tok[2:3] == b"" or ei_tok[2:3] in WHITESPACES): raise PdfReadError("EI stream not found") return data_out def extract_inline_default(stream: StreamType) -> bytes: """Legacy method, used by default""" stream_out = BytesIO() # Read the inline image, while checking for EI (End Image) operator. while True: data_buffered = stream.read(BUFFER_SIZE) if not data_buffered: raise PdfReadError("Unexpected end of stream") pos_ei = data_buffered.find( b"E" ) # We can not look straight for "EI" because it may not have been loaded in the buffer if pos_ei == -1: stream_out.write(data_buffered) else: # Write out everything including E (the one from EI to be removed) stream_out.write(data_buffered[0 : pos_ei + 1]) sav_pos_ei = stream_out.tell() - 1 # Seek back in the stream to read the E next stream.seek(pos_ei + 1 - len(data_buffered), 1) saved_pos = stream.tell() # Check for End Image tok2 = stream.read(1) # I of "EI" if tok2 != b"I": stream.seek(saved_pos, 0) continue tok3 = stream.read(1) # possible space after "EI" if tok3 not in WHITESPACES: stream.seek(saved_pos, 0) continue while tok3 in WHITESPACES: tok3 = stream.read(1) if data_buffered[pos_ei - 1 : pos_ei] not in WHITESPACES and tok3 not in { b"Q", b"E", }: # for Q or EMC stream.seek(saved_pos, 0) continue if is_followed_by_binary_data(stream): # Inline image contains `EI ` sequence usually marking the end of it, but # is followed by binary data which does not make sense for the actual end. stream.seek(saved_pos, 0) continue # Data contains [\s]EI[\s](Q|EMC): 4 chars are sufficient # remove E(I) wrongly inserted earlier stream.seek(saved_pos - 1, 0) stream_out.truncate(sav_pos_ei) break return stream_out.getvalue() def is_followed_by_binary_data(stream: IO[bytes], length: int = 10) -> bool: """ Check if the next bytes of the stream look like binary image data or regular page content. This is just some heuristics due to the PDF specification being too imprecise about inline images containing the `EI` marker which would end an image. Starting with PDF 2.0, we finally get a mandatory length field, but with (proper) PDF 2.0 support being very limited everywhere, we should not expect to be able to remove such hacks in the near future - especially considering legacy documents as well. The actual implementation draws some inspiration from https://github.com/itext/itext-java/blob/9.1.0/kernel/src/main/java/com/itextpdf/kernel/pdf/canvas/parser/util/InlineImageParsingUtils.java """ position = stream.tell() data = stream.read(length) stream.seek(position) if not data: return False operator_start = None operator_end = None for index, byte in enumerate(data): if byte < 32 and byte not in WHITESPACES_AS_BYTES: # This covers all characters not being displayable directly, although omitting whitespace # to allow for operator detection. return True is_whitespace = byte in WHITESPACES_AS_BYTES if operator_start is None and not is_whitespace: # Interpret all other non-whitespace characters as the start of an operation. operator_start = index if operator_start is not None and is_whitespace: # A whitespace stops an operation. # Assume that having an inline image with tons of whitespace is rather unlikely. operator_end = index break if operator_start is None: # Inline images should not have tons of whitespaces, which would lead to no operator start. return False if operator_end is None: # We probably are inside an operation. operator_end = length operator_length = operator_end - operator_start operator = data[operator_start:operator_end] if operator.startswith(b"/") and operator_length > 1: # Name object. return False if operator.replace(b".", b"").isdigit(): # Graphics operator, for example a move. A number (integer or float). return False if operator_length > 3: # noqa: SIM103 # Usually, the operators inside a content stream should not have more than three characters, # especially after an inline image. return True return False pypdf-6.1.2/pypdf/generic/_link.py000066400000000000000000000115271507516550200170620ustar00rootroot00000000000000# All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. # This module contains code used by _writer.py to track links in pages # being added to the writer until the links can be resolved. from typing import TYPE_CHECKING, Optional, Union, cast from . import ArrayObject, DictionaryObject, IndirectObject, PdfObject, TextStringObject if TYPE_CHECKING: from .._page import PageObject from .._reader import PdfReader from .._writer import PdfWriter class NamedReferenceLink: """Named reference link being preserved until we can resolve it correctly.""" def __init__(self, reference: TextStringObject, source_pdf: "PdfReader") -> None: """reference: TextStringObject with named reference""" self._reference = reference self._source_pdf = source_pdf def find_referenced_page(self) -> Union[IndirectObject, None]: destination = self._source_pdf.named_destinations.get(str(self._reference)) return destination.page if destination else None def patch_reference(self, target_pdf: "PdfWriter", new_page: IndirectObject) -> None: """target_pdf: PdfWriter which the new link went into""" # point named destination in new PDF to the new page if str(self._reference) not in target_pdf.named_destinations: target_pdf.add_named_destination(str(self._reference), new_page.page_number) class DirectReferenceLink: """Direct reference link being preserved until we can resolve it correctly.""" def __init__(self, reference: ArrayObject) -> None: """reference: an ArrayObject whose first element is the Page indirect object""" self._reference = reference def find_referenced_page(self) -> IndirectObject: return self._reference[0] def patch_reference(self, target_pdf: "PdfWriter", new_page: IndirectObject) -> None: """target_pdf: PdfWriter which the new link went into""" self._reference[0] = new_page ReferenceLink = Union[NamedReferenceLink, DirectReferenceLink] def extract_links(new_page: "PageObject", old_page: "PageObject") -> list[tuple[ReferenceLink, ReferenceLink]]: """Extracts links from two pages on the assumption that the two pages are the same. Produces one list of (new link, old link) tuples. """ new_links = [_build_link(link, new_page) for link in new_page.get("/Annots", [])] old_links = [_build_link(link, old_page) for link in old_page.get("/Annots", [])] return [ (new_link, old_link) for (new_link, old_link) in zip(new_links, old_links) if new_link and old_link ] def _build_link(indirect_object: IndirectObject, page: "PageObject") -> Optional[ReferenceLink]: src = cast("PdfReader", page.pdf) link = cast(DictionaryObject, indirect_object.get_object()) if (not isinstance(link, DictionaryObject)) or link.get("/Subtype") != "/Link": return None if "/A" in link: action = cast(DictionaryObject, link["/A"]) if action.get("/S") != "/GoTo": return None if "/D" not in action: return None return _create_link(action["/D"], src) if "/Dest" in link: return _create_link(link["/Dest"], src) return None # Nothing to do here def _create_link(reference: PdfObject, source_pdf: "PdfReader")-> Optional[ReferenceLink]: if isinstance(reference, TextStringObject): return NamedReferenceLink(reference, source_pdf) if isinstance(reference, ArrayObject): return DirectReferenceLink(reference) return None pypdf-6.1.2/pypdf/generic/_outline.py000066400000000000000000000021061507516550200175750ustar00rootroot00000000000000from typing import Union from .._utils import StreamType, deprecation_no_replacement from ._base import NameObject from ._data_structures import Destination class OutlineItem(Destination): def write_to_stream( self, stream: StreamType, encryption_key: Union[None, str, bytes] = None ) -> None: if encryption_key is not None: # deprecated deprecation_no_replacement( "the encryption_key parameter of write_to_stream", "5.0.0" ) stream.write(b"<<\n") for key in [ NameObject(x) for x in ["/Title", "/Parent", "/First", "/Last", "/Next", "/Prev"] if x in self ]: key.write_to_stream(stream) stream.write(b" ") value = self.raw_get(key) value.write_to_stream(stream) stream.write(b"\n") key = NameObject("/Dest") key.write_to_stream(stream) stream.write(b" ") value = self.dest_array value.write_to_stream(stream) stream.write(b"\n") stream.write(b">>") pypdf-6.1.2/pypdf/generic/_rectangle.py000066400000000000000000000073111507516550200200650ustar00rootroot00000000000000from typing import Any, Union from ._base import FloatObject, NumberObject from ._data_structures import ArrayObject class RectangleObject(ArrayObject): """ This class is used to represent *page boxes* in pypdf. These boxes include: * :attr:`artbox ` * :attr:`bleedbox ` * :attr:`cropbox ` * :attr:`mediabox ` * :attr:`trimbox ` """ def __init__( self, arr: Union["RectangleObject", tuple[float, float, float, float]] ) -> None: # must have four points assert len(arr) == 4 # automatically convert arr[x] into NumberObject(arr[x]) if necessary ArrayObject.__init__(self, [self._ensure_is_number(x) for x in arr]) def _ensure_is_number(self, value: Any) -> Union[FloatObject, NumberObject]: if not isinstance(value, (FloatObject, NumberObject)): value = FloatObject(value) return value def scale(self, sx: float, sy: float) -> "RectangleObject": return RectangleObject( ( float(self.left) * sx, float(self.bottom) * sy, float(self.right) * sx, float(self.top) * sy, ) ) def __repr__(self) -> str: return f"RectangleObject({list(self)!r})" @property def left(self) -> FloatObject: return self[0] @left.setter def left(self, f: float) -> None: self[0] = FloatObject(f) @property def bottom(self) -> FloatObject: return self[1] @bottom.setter def bottom(self, f: float) -> None: self[1] = FloatObject(f) @property def right(self) -> FloatObject: return self[2] @right.setter def right(self, f: float) -> None: self[2] = FloatObject(f) @property def top(self) -> FloatObject: return self[3] @top.setter def top(self, f: float) -> None: self[3] = FloatObject(f) @property def lower_left(self) -> tuple[float, float]: """ Property to read and modify the lower left coordinate of this box in (x,y) form. """ return self.left, self.bottom @lower_left.setter def lower_left(self, value: tuple[float, float]) -> None: self[0], self[1] = (self._ensure_is_number(x) for x in value) @property def lower_right(self) -> tuple[float, float]: """ Property to read and modify the lower right coordinate of this box in (x,y) form. """ return self.right, self.bottom @lower_right.setter def lower_right(self, value: tuple[float, float]) -> None: self[2], self[1] = (self._ensure_is_number(x) for x in value) @property def upper_left(self) -> tuple[float, float]: """ Property to read and modify the upper left coordinate of this box in (x,y) form. """ return self.left, self.top @upper_left.setter def upper_left(self, value: tuple[float, float]) -> None: self[0], self[3] = (self._ensure_is_number(x) for x in value) @property def upper_right(self) -> tuple[float, float]: """ Property to read and modify the upper right coordinate of this box in (x,y) form. """ return self.right, self.top @upper_right.setter def upper_right(self, value: tuple[float, float]) -> None: self[2], self[3] = (self._ensure_is_number(x) for x in value) @property def width(self) -> float: return self.right - self.left @property def height(self) -> float: return self.top - self.bottom pypdf-6.1.2/pypdf/generic/_utils.py000066400000000000000000000161321507516550200172620ustar00rootroot00000000000000import codecs from typing import Union from .._codecs import _pdfdoc_encoding from .._utils import StreamType, logger_warning, read_non_whitespace from ..errors import STREAM_TRUNCATED_PREMATURELY, PdfStreamError from ._base import ByteStringObject, TextStringObject def hex_to_rgb(value: str) -> tuple[float, float, float]: return tuple(int(value.lstrip("#")[i : i + 2], 16) / 255.0 for i in (0, 2, 4)) # type: ignore def read_hex_string_from_stream( stream: StreamType, forced_encoding: Union[None, str, list[str], dict[int, str]] = None, ) -> Union["TextStringObject", "ByteStringObject"]: stream.read(1) arr = [] x = b"" while True: tok = read_non_whitespace(stream) if not tok: raise PdfStreamError(STREAM_TRUNCATED_PREMATURELY) if tok == b">": break x += tok if len(x) == 2: arr.append(int(x, base=16)) x = b"" if len(x) == 1: x += b"0" if x != b"": arr.append(int(x, base=16)) return create_string_object(bytes(arr), forced_encoding) __ESCAPE_DICT__ = { b"n": ord(b"\n"), b"r": ord(b"\r"), b"t": ord(b"\t"), b"b": ord(b"\b"), b"f": ord(b"\f"), b"(": ord(b"("), b")": ord(b")"), b"/": ord(b"/"), b"\\": ord(b"\\"), b" ": ord(b" "), b"%": ord(b"%"), b"<": ord(b"<"), b">": ord(b">"), b"[": ord(b"["), b"]": ord(b"]"), b"#": ord(b"#"), b"_": ord(b"_"), b"&": ord(b"&"), b"$": ord(b"$"), } __BACKSLASH_CODE__ = 92 def read_string_from_stream( stream: StreamType, forced_encoding: Union[None, str, list[str], dict[int, str]] = None, ) -> Union["TextStringObject", "ByteStringObject"]: tok = stream.read(1) parens = 1 txt = [] while True: tok = stream.read(1) if not tok: raise PdfStreamError(STREAM_TRUNCATED_PREMATURELY) if tok == b"(": parens += 1 elif tok == b")": parens -= 1 if parens == 0: break elif tok == b"\\": tok = stream.read(1) try: txt.append(__ESCAPE_DICT__[tok]) continue except KeyError: if b"0" <= tok <= b"7": # "The number ddd may consist of one, two, or three # octal digits; high-order overflow shall be ignored. # Three octal digits shall be used, with leading zeros # as needed, if the next character of the string is also # a digit." (PDF reference 7.3.4.2, p 16) sav = stream.tell() - 1 for _ in range(2): ntok = stream.read(1) if b"0" <= ntok <= b"7": tok += ntok else: stream.seek(-1, 1) # ntok has to be analyzed break i = int(tok, base=8) if i > 255: txt.append(__BACKSLASH_CODE__) stream.seek(sav) else: txt.append(i) continue if tok in b"\n\r": # This case is hit when a backslash followed by a line # break occurs. If it's a multi-char EOL, consume the # second character: tok = stream.read(1) if tok not in b"\n\r": stream.seek(-1, 1) # Then don't add anything to the actual string, since this # line break was escaped: continue msg = f"Unexpected escaped string: {tok.decode('utf-8', 'ignore')}" logger_warning(msg, __name__) txt.append(__BACKSLASH_CODE__) txt.append(ord(tok)) return create_string_object(bytes(txt), forced_encoding) def create_string_object( string: Union[str, bytes], forced_encoding: Union[None, str, list[str], dict[int, str]] = None, ) -> Union[TextStringObject, ByteStringObject]: """ Create a ByteStringObject or a TextStringObject from a string to represent the string. Args: string: The data being used forced_encoding: Typically None, or an encoding string Returns: A ByteStringObject Raises: TypeError: If string is not of type str or bytes. """ if isinstance(string, str): return TextStringObject(string) if isinstance(string, bytes): if isinstance(forced_encoding, (list, dict)): out = "" for x in string: try: out += forced_encoding[x] except Exception: out += bytes((x,)).decode("charmap") obj = TextStringObject(out) obj._original_bytes = string return obj if isinstance(forced_encoding, str): if forced_encoding == "bytes": return ByteStringObject(string) obj = TextStringObject(string.decode(forced_encoding)) obj._original_bytes = string return obj try: if string.startswith((codecs.BOM_UTF16_BE, codecs.BOM_UTF16_LE)): retval = TextStringObject(string.decode("utf-16")) retval._original_bytes = string retval.autodetect_utf16 = True retval.utf16_bom = string[:2] return retval if string.startswith(b"\x00"): retval = TextStringObject(string.decode("utf-16be")) retval._original_bytes = string retval.autodetect_utf16 = True retval.utf16_bom = codecs.BOM_UTF16_BE return retval if string[1:2] == b"\x00": retval = TextStringObject(string.decode("utf-16le")) retval._original_bytes = string retval.autodetect_utf16 = True retval.utf16_bom = codecs.BOM_UTF16_LE return retval # This is probably a big performance hit here, but we need # to convert string objects into the text/unicode-aware # version if possible... and the only way to check if that's # possible is to try. # Some strings are strings, some are just byte arrays. retval = TextStringObject(decode_pdfdocencoding(string)) retval._original_bytes = string retval.autodetect_pdfdocencoding = True return retval except UnicodeDecodeError: return ByteStringObject(string) else: raise TypeError("create_string_object should have str or unicode arg") def decode_pdfdocencoding(byte_array: bytes) -> str: retval = "" for b in byte_array: c = _pdfdoc_encoding[b] if c == "\u0000": raise UnicodeDecodeError( "pdfdocencoding", bytearray(b), -1, -1, "does not exist in translation table", ) retval += c return retval pypdf-6.1.2/pypdf/generic/_viewerpref.py000066400000000000000000000151461507516550200203040ustar00rootroot00000000000000# Copyright (c) 2023, Pubpub-ZZ # # All rights reserved. # # Redistribution and use in source and binary forms, with or without # modification, are permitted provided that the following conditions are # met: # # * Redistributions of source code must retain the above copyright notice, # this list of conditions and the following disclaimer. # * Redistributions in binary form must reproduce the above copyright notice, # this list of conditions and the following disclaimer in the documentation # and/or other materials provided with the distribution. # * The name of the author may not be used to endorse or promote products # derived from this software without specific prior written permission. # # THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" # AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE # IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE # ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE # LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR # CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF # SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS # INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN # CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) # ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE # POSSIBILITY OF SUCH DAMAGE. from typing import ( Any, Optional, ) from ._base import BooleanObject, NameObject, NumberObject, is_null_or_none from ._data_structures import ArrayObject, DictionaryObject f_obj = BooleanObject(False) class ViewerPreferences(DictionaryObject): def __init__(self, obj: Optional[DictionaryObject] = None) -> None: super().__init__(self) if not is_null_or_none(obj): self.update(obj.items()) # type: ignore try: self.indirect_reference = obj.indirect_reference # type: ignore except AttributeError: pass def _get_bool(self, key: str, default: Optional[BooleanObject]) -> Optional[BooleanObject]: return self.get(key, default) def _set_bool(self, key: str, v: bool) -> None: self[NameObject(key)] = BooleanObject(v is True) def _get_name(self, key: str, default: Optional[NameObject]) -> Optional[NameObject]: return self.get(key, default) def _set_name(self, key: str, lst: list[str], v: NameObject) -> None: if v[0] != "/": raise ValueError(f"{v} does not start with '/'") if lst != [] and v not in lst: raise ValueError(f"{v} is an unacceptable value") self[NameObject(key)] = NameObject(v) def _get_arr(self, key: str, default: Optional[list[Any]]) -> Optional[ArrayObject]: return self.get(key, None if default is None else ArrayObject(default)) def _set_arr(self, key: str, v: Optional[ArrayObject]) -> None: if v is None: try: del self[NameObject(key)] except KeyError: pass return if not isinstance(v, ArrayObject): raise ValueError("ArrayObject is expected") self[NameObject(key)] = v def _get_int(self, key: str, default: Optional[NumberObject]) -> Optional[NumberObject]: return self.get(key, default) def _set_int(self, key: str, v: int) -> None: self[NameObject(key)] = NumberObject(v) @property def PRINT_SCALING(self) -> NameObject: return NameObject("/PrintScaling") def __new__(cls: Any, value: Any = None) -> "ViewerPreferences": def _add_prop_bool(key: str, default: Optional[BooleanObject]) -> property: return property( lambda self: self._get_bool(key, default), lambda self, v: self._set_bool(key, v), None, f""" Returns/Modify the status of {key}, Returns {default} if not defined """, ) def _add_prop_name( key: str, lst: list[str], default: Optional[NameObject] ) -> property: return property( lambda self: self._get_name(key, default), lambda self, v: self._set_name(key, lst, v), None, f""" Returns/Modify the status of {key}, Returns {default} if not defined. Acceptable values: {lst} """, ) def _add_prop_arr(key: str, default: Optional[ArrayObject]) -> property: return property( lambda self: self._get_arr(key, default), lambda self, v: self._set_arr(key, v), None, f""" Returns/Modify the status of {key}, Returns {default} if not defined """, ) def _add_prop_int(key: str, default: Optional[int]) -> property: return property( lambda self: self._get_int(key, default), lambda self, v: self._set_int(key, v), None, f""" Returns/Modify the status of {key}, Returns {default} if not defined """, ) cls.hide_toolbar = _add_prop_bool("/HideToolbar", f_obj) cls.hide_menubar = _add_prop_bool("/HideMenubar", f_obj) cls.hide_windowui = _add_prop_bool("/HideWindowUI", f_obj) cls.fit_window = _add_prop_bool("/FitWindow", f_obj) cls.center_window = _add_prop_bool("/CenterWindow", f_obj) cls.display_doctitle = _add_prop_bool("/DisplayDocTitle", f_obj) cls.non_fullscreen_pagemode = _add_prop_name( "/NonFullScreenPageMode", ["/UseNone", "/UseOutlines", "/UseThumbs", "/UseOC"], NameObject("/UseNone"), ) cls.direction = _add_prop_name( "/Direction", ["/L2R", "/R2L"], NameObject("/L2R") ) cls.view_area = _add_prop_name("/ViewArea", [], None) cls.view_clip = _add_prop_name("/ViewClip", [], None) cls.print_area = _add_prop_name("/PrintArea", [], None) cls.print_clip = _add_prop_name("/PrintClip", [], None) cls.print_scaling = _add_prop_name("/PrintScaling", [], None) cls.duplex = _add_prop_name( "/Duplex", ["/Simplex", "/DuplexFlipShortEdge", "/DuplexFlipLongEdge"], None ) cls.pick_tray_by_pdfsize = _add_prop_bool("/PickTrayByPDFSize", None) cls.print_pagerange = _add_prop_arr("/PrintPageRange", None) cls.num_copies = _add_prop_int("/NumCopies", None) cls.enforce = _add_prop_arr("/Enforce", ArrayObject()) return DictionaryObject.__new__(cls) pypdf-6.1.2/pypdf/pagerange.py000066400000000000000000000157041507516550200163040ustar00rootroot00000000000000""" Representation and utils for ranges of PDF file pages. Copyright (c) 2014, Steve Witham . All rights reserved. This software is available under a BSD license; see https://github.com/py-pdf/pypdf/blob/main/LICENSE """ import re from typing import Any, Union from .errors import ParseError _INT_RE = r"(0|-?[1-9]\d*)" # A decimal int, don't allow "-0". PAGE_RANGE_RE = f"^({_INT_RE}|({_INT_RE}?(:{_INT_RE}?(:{_INT_RE}?)?)))$" # groups: 12 34 5 6 7 8 class PageRange: """ A slice-like representation of a range of page indices. For example, page numbers, only starting at zero. The syntax is like what you would put between brackets [ ]. The slice is one of the few Python types that can't be subclassed, but this class converts to and from slices, and allows similar use. - PageRange(str) parses a string representing a page range. - PageRange(slice) directly "imports" a slice. - to_slice() gives the equivalent slice. - str() and repr() allow printing. - indices(n) is like slice.indices(n). """ def __init__(self, arg: Union[slice, "PageRange", str]) -> None: """ Initialize with either a slice -- giving the equivalent page range, or a PageRange object -- making a copy, or a string like "int", "[int]:[int]" or "[int]:[int]:[int]", where the brackets indicate optional ints. Remember, page indices start with zero. Page range expression examples: : all pages. -1 last page. 22 just the 23rd page. :-1 all but the last page. 0:3 the first three pages. -2 second-to-last page. :3 the first three pages. -2: last two pages. 5: from the sixth page onward. -3:-1 third & second to last. The third, "stride" or "step" number is also recognized. ::2 0 2 4 ... to the end. 3:0:-1 3 2 1 but not 0. 1:10:2 1 3 5 7 9 2::-1 2 1 0. ::-1 all pages in reverse order. Note the difference between this notation and arguments to slice(): slice(3) means the first three pages; PageRange("3") means the range of only the fourth page. However PageRange(slice(3)) means the first three pages. """ if isinstance(arg, slice): self._slice = arg return if isinstance(arg, PageRange): self._slice = arg.to_slice() return m = isinstance(arg, str) and re.match(PAGE_RANGE_RE, arg) if not m: raise ParseError(arg) if m.group(2): # Special case: just an int means a range of one page. start = int(m.group(2)) stop = start + 1 if start != -1 else None self._slice = slice(start, stop) else: self._slice = slice(*[int(g) if g else None for g in m.group(4, 6, 8)]) @staticmethod def valid(input: Any) -> bool: """ True if input is a valid initializer for a PageRange. Args: input: A possible PageRange string or a PageRange object. Returns: True, if the ``input`` is a valid PageRange. """ return isinstance(input, (slice, PageRange)) or ( isinstance(input, str) and bool(re.match(PAGE_RANGE_RE, input)) ) def to_slice(self) -> slice: """Return the slice equivalent of this page range.""" return self._slice def __str__(self) -> str: """A string like "1:2:3".""" s = self._slice indices: Union[tuple[int, int], tuple[int, int, int]] if s.step is None: if s.start is not None and s.stop == s.start + 1: return str(s.start) indices = s.start, s.stop else: indices = s.start, s.stop, s.step return ":".join("" if i is None else str(i) for i in indices) def __repr__(self) -> str: """A string like "PageRange('1:2:3')".""" return "PageRange(" + repr(str(self)) + ")" def indices(self, n: int) -> tuple[int, int, int]: """ Assuming a sequence of length n, calculate the start and stop indices, and the stride length of the PageRange. See help(slice.indices). Args: n: the length of the list of pages to choose from. Returns: Arguments for range(). """ return self._slice.indices(n) def __eq__(self, other: object) -> bool: if not isinstance(other, PageRange): return False return self._slice == other._slice def __hash__(self) -> int: return hash((self.__class__, (self._slice.start, self._slice.stop, self._slice.step))) def __add__(self, other: "PageRange") -> "PageRange": if not isinstance(other, PageRange): raise TypeError(f"Can't add PageRange and {type(other)}") if self._slice.step is not None or other._slice.step is not None: raise ValueError("Can't add PageRange with stride") a = self._slice.start, self._slice.stop b = other._slice.start, other._slice.stop if a[0] > b[0]: a, b = b, a # Now a[0] is the smallest if b[0] > a[1]: # There is a gap between a and b. raise ValueError("Can't add PageRanges with gap") return PageRange(slice(a[0], max(a[1], b[1]))) PAGE_RANGE_ALL = PageRange(":") # The range of all pages. def parse_filename_page_ranges( args: list[Union[str, PageRange, None]] ) -> list[tuple[str, PageRange]]: """ Given a list of filenames and page ranges, return a list of (filename, page_range) pairs. Args: args: A list where the first element is a filename. The other elements are filenames, page-range expressions, slice objects, or PageRange objects. A filename not followed by a page range indicates all pages of the file. Returns: A list of (filename, page_range) pairs. """ pairs: list[tuple[str, PageRange]] = [] pdf_filename: Union[str, None] = None did_page_range = False for arg in [*args, None]: if PageRange.valid(arg): if not pdf_filename: raise ValueError( "The first argument must be a filename, not a page range." ) assert arg is not None pairs.append((pdf_filename, PageRange(arg))) did_page_range = True else: # New filename or end of list - use the complete previous file? if pdf_filename and not did_page_range: pairs.append((pdf_filename, PAGE_RANGE_ALL)) assert not isinstance(arg, PageRange), arg pdf_filename = arg did_page_range = False return pairs PageRangeSpec = Union[str, PageRange, tuple[int, int], tuple[int, int, int], list[int]] pypdf-6.1.2/pypdf/papersizes.py000066400000000000000000000026051507516550200165340ustar00rootroot00000000000000"""Helper to get paper sizes.""" from typing import NamedTuple class Dimensions(NamedTuple): width: int height: int class PaperSize: """(width, height) of the paper in portrait mode in pixels at 72 ppi.""" # Notes of how to calculate it: # 1. Get the size of the paper in millimeters # 2. Convert it to inches (25.4 millimeters is equal to 1 inch) # 3. Convert it to pixels at 72dpi (1 inch is equal to 72 pixels) # All Din-A paper sizes follow this pattern: # 2 x A(n - 1) = A(n) # So the height of the next bigger one is the width of the smaller one # The ratio is always approximately 1:2**0.5 # Additionally, A0 is defined to have an area of 1 m**2 # https://en.wikipedia.org/wiki/ISO_216 # Be aware of rounding issues! A0 = Dimensions(2384, 3370) # 841mm x 1189mm A1 = Dimensions(1684, 2384) A2 = Dimensions(1191, 1684) A3 = Dimensions(842, 1191) A4 = Dimensions( 595, 842 ) # Printer paper, documents - this is by far the most common A5 = Dimensions(420, 595) # Paperback books A6 = Dimensions(298, 420) # Postcards A7 = Dimensions(210, 298) A8 = Dimensions(147, 210) # Envelopes C4 = Dimensions(649, 918) _din_a = ( PaperSize.A0, PaperSize.A1, PaperSize.A2, PaperSize.A3, PaperSize.A4, PaperSize.A5, PaperSize.A6, PaperSize.A7, PaperSize.A8, ) pypdf-6.1.2/pypdf/py.typed000066400000000000000000000000001507516550200154570ustar00rootroot00000000000000pypdf-6.1.2/pypdf/types.py000066400000000000000000000035731507516550200155200ustar00rootroot00000000000000"""Helpers for working with PDF types.""" import sys from typing import Literal, Union if sys.version_info[:2] >= (3, 10): # Python 3.10+: https://www.python.org/dev/peps/pep-0484 from typing import TypeAlias else: from typing_extensions import TypeAlias from .generic._base import NameObject, NullObject, NumberObject from .generic._data_structures import ArrayObject, Destination from .generic._outline import OutlineItem BorderArrayType: TypeAlias = list[Union[NameObject, NumberObject, ArrayObject]] OutlineItemType: TypeAlias = Union[OutlineItem, Destination] FitType: TypeAlias = Literal[ "/XYZ", "/Fit", "/FitH", "/FitV", "/FitR", "/FitB", "/FitBH", "/FitBV" ] # These go with the FitType, they specify values for the fit ZoomArgType: TypeAlias = Union[NumberObject, NullObject, float] ZoomArgsType: TypeAlias = list[ZoomArgType] # Recursive types like the following are not yet supported by Sphinx: # OutlineType = List[Union[Destination, "OutlineType"]] # Hence use this for the moment: OutlineType = list[Union[Destination, list[Union[Destination, list[Destination]]]]] LayoutType: TypeAlias = Literal[ "/NoLayout", "/SinglePage", "/OneColumn", "/TwoColumnLeft", "/TwoColumnRight", "/TwoPageLeft", "/TwoPageRight", ] PagemodeType: TypeAlias = Literal[ "/UseNone", "/UseOutlines", "/UseThumbs", "/FullScreen", "/UseOC", "/UseAttachments", ] AnnotationSubtype: TypeAlias = Literal[ "/Text", "/Link", "/FreeText", "/Line", "/Square", "/Circle", "/Polygon", "/PolyLine", "/Highlight", "/Underline", "/Squiggly", "/StrikeOut", "/Caret", "/Stamp", "/Ink", "/Popup", "/FileAttachment", "/Sound", "/Movie", "/Screen", "/Widget", "/PrinterMark", "/TrapNet", "/Watermark", "/3D", "/Redact", "/Projection", "/RichMedia", ] pypdf-6.1.2/pypdf/xmp.py000066400000000000000000000710661507516550200151620ustar00rootroot00000000000000""" Anything related to Extensible Metadata Platform (XMP) metadata. https://en.wikipedia.org/wiki/Extensible_Metadata_Platform """ import datetime import decimal import re from collections.abc import Iterator from typing import ( Any, Callable, Optional, TypeVar, Union, ) from xml.dom.minidom import Document, parseString from xml.dom.minidom import Element as XmlElement from xml.parsers.expat import ExpatError from ._protocols import XmpInformationProtocol from ._utils import StreamType, deprecate_with_replacement, deprecation_no_replacement from .errors import PdfReadError, XmpDocumentError from .generic import ContentStream, PdfObject RDF_NAMESPACE = "http://www.w3.org/1999/02/22-rdf-syntax-ns#" DC_NAMESPACE = "http://purl.org/dc/elements/1.1/" XMP_NAMESPACE = "http://ns.adobe.com/xap/1.0/" PDF_NAMESPACE = "http://ns.adobe.com/pdf/1.3/" XMPMM_NAMESPACE = "http://ns.adobe.com/xap/1.0/mm/" # What is the PDFX namespace, you might ask? # It's documented here: https://github.com/adobe/xmp-docs/raw/master/XMPSpecifications/XMPSpecificationPart3.pdf # This namespace is used to place "custom metadata" # properties, which are arbitrary metadata properties with no semantic or # documented meaning. # # Elements in the namespace are key/value-style storage, # where the element name is the key and the content is the value. The keys # are transformed into valid XML identifiers by substituting an invalid # identifier character with \u2182 followed by the unicode hex ID of the # original character. A key like "my car" is therefore "my\u21820020car". # # \u2182 is the unicode character \u{ROMAN NUMERAL TEN THOUSAND} # # The pdfx namespace should be avoided. # A custom data schema and sensical XML elements could be used instead, as is # suggested by Adobe's own documentation on XMP under "Extensibility of # Schemas". PDFX_NAMESPACE = "http://ns.adobe.com/pdfx/1.3/" # PDF/A PDFAID_NAMESPACE = "http://www.aiim.org/pdfa/ns/id/" # Internal mapping of namespace URI → prefix _NAMESPACE_PREFIX_MAP = { DC_NAMESPACE: "dc", XMP_NAMESPACE: "xmp", PDF_NAMESPACE: "pdf", XMPMM_NAMESPACE: "xmpMM", PDFAID_NAMESPACE: "pdfaid", PDFX_NAMESPACE: "pdfx", } iso8601 = re.compile( """ (?P[0-9]{4}) (- (?P[0-9]{2}) (- (?P[0-9]+) (T (?P[0-9]{2}): (?P[0-9]{2}) (:(?P[0-9]{2}(.[0-9]+)?))? (?PZ|[-+][0-9]{2}:[0-9]{2}) )? )? )? """, re.VERBOSE, ) K = TypeVar("K") # Minimal XMP template _MINIMAL_XMP = f""" """ def _identity(value: K) -> K: return value def _converter_date(value: str) -> datetime.datetime: matches = iso8601.match(value) if matches is None: raise ValueError(f"Invalid date format: {value}") year = int(matches.group("year")) month = int(matches.group("month") or "1") day = int(matches.group("day") or "1") hour = int(matches.group("hour") or "0") minute = int(matches.group("minute") or "0") second = decimal.Decimal(matches.group("second") or "0") seconds_dec = second.to_integral(decimal.ROUND_FLOOR) milliseconds_dec = (second - seconds_dec) * 1_000_000 seconds = int(seconds_dec) milliseconds = int(milliseconds_dec) tzd = matches.group("tzd") or "Z" dt = datetime.datetime(year, month, day, hour, minute, seconds, milliseconds) if tzd != "Z": tzd_hours, tzd_minutes = (int(x) for x in tzd.split(":")) tzd_hours *= -1 if tzd_hours < 0: tzd_minutes *= -1 dt = dt + datetime.timedelta(hours=tzd_hours, minutes=tzd_minutes) return dt def _format_datetime_utc(value: datetime.datetime) -> str: """Format a datetime as UTC with trailing 'Z'. - If the input is timezone-aware, convert to UTC first. - If naive, assume UTC. """ if value.tzinfo is not None and value.utcoffset() is not None: value = value.astimezone(datetime.timezone.utc) value = value.replace(tzinfo=None) return value.strftime("%Y-%m-%dT%H:%M:%S.%fZ") def _generic_get( element: XmlElement, self: "XmpInformation", list_type: str, converter: Callable[[Any], Any] = _identity ) -> Optional[list[str]]: containers = element.getElementsByTagNameNS(RDF_NAMESPACE, list_type) retval: list[Any] = [] if len(containers): for container in containers: for item in container.getElementsByTagNameNS(RDF_NAMESPACE, "li"): value = self._get_text(item) value = converter(value) retval.append(value) return retval return None class XmpInformation(XmpInformationProtocol, PdfObject): """ An object that represents Extensible Metadata Platform (XMP) metadata. Usually accessed by :py:attr:`xmp_metadata()`. Raises: PdfReadError: if XML is invalid """ def __init__(self, stream: ContentStream) -> None: self.stream = stream try: data = self.stream.get_data() doc_root: Document = parseString(data) # noqa: S318 except (AttributeError, ExpatError) as e: raise PdfReadError(f"XML in XmpInformation was invalid: {e}") self.rdf_root: XmlElement = doc_root.getElementsByTagNameNS( RDF_NAMESPACE, "RDF" )[0] self.cache: dict[Any, Any] = {} @classmethod def create(cls) -> "XmpInformation": """ Create a new XmpInformation object with minimal structure. Returns: A new XmpInformation instance with empty metadata fields. """ stream = ContentStream(None, None) stream.set_data(_MINIMAL_XMP.encode("utf-8")) return cls(stream) def write_to_stream( self, stream: StreamType, encryption_key: Union[None, str, bytes] = None ) -> None: deprecate_with_replacement( "XmpInformation.write_to_stream", "PdfWriter.xmp_metadata", "6.0.0" ) if encryption_key is not None: # deprecated deprecation_no_replacement( "the encryption_key parameter of write_to_stream", "5.0.0" ) self.stream.write_to_stream(stream) def get_element(self, about_uri: str, namespace: str, name: str) -> Iterator[Any]: for desc in self.rdf_root.getElementsByTagNameNS(RDF_NAMESPACE, "Description"): if desc.getAttributeNS(RDF_NAMESPACE, "about") == about_uri: attr = desc.getAttributeNodeNS(namespace, name) if attr is not None: yield attr yield from desc.getElementsByTagNameNS(namespace, name) def get_nodes_in_namespace(self, about_uri: str, namespace: str) -> Iterator[Any]: for desc in self.rdf_root.getElementsByTagNameNS(RDF_NAMESPACE, "Description"): if desc.getAttributeNS(RDF_NAMESPACE, "about") == about_uri: for i in range(desc.attributes.length): attr = desc.attributes.item(i) if attr and attr.namespaceURI == namespace: yield attr for child in desc.childNodes: if child.namespaceURI == namespace: yield child def _get_text(self, element: XmlElement) -> str: text = "" for child in element.childNodes: if child.nodeType == child.TEXT_NODE: text += child.data return text def _get_single_value( self, namespace: str, name: str, converter: Callable[[str], Any] = _identity, ) -> Optional[Any]: cached = self.cache.get(namespace, {}).get(name) if cached: return cached value = None for element in self.get_element("", namespace, name): if element.nodeType == element.ATTRIBUTE_NODE: value = element.nodeValue else: value = self._get_text(element) break if value is not None: value = converter(value) ns_cache = self.cache.setdefault(namespace, {}) ns_cache[name] = value return value def _getter_bag(self, namespace: str, name: str) -> Optional[list[str]]: cached = self.cache.get(namespace, {}).get(name) if cached: return cached retval: list[str] = [] for element in self.get_element("", namespace, name): if (bags := _generic_get(element, self, list_type="Bag")) is not None: retval.extend(bags) else: value = self._get_text(element) retval.append(value) ns_cache = self.cache.setdefault(namespace, {}) ns_cache[name] = retval return retval def _get_seq_values( self, namespace: str, name: str, converter: Callable[[Any], Any] = _identity, ) -> Optional[list[Any]]: cached = self.cache.get(namespace, {}).get(name) if cached: return cached retval: list[Any] = [] for element in self.get_element("", namespace, name): if (seqs := _generic_get(element, self, list_type="Seq", converter=converter)) is not None: retval.extend(seqs) elif (bags := _generic_get(element, self, list_type="Bag")) is not None: # See issue at https://github.com/py-pdf/pypdf/issues/3324 # Some applications violate the XMP metadata standard regarding `dc:creator` which should # be an "ordered array" and thus a sequence, but use an unordered array (bag) instead. # This seems to stem from the fact that the original Dublin Core specification does indeed # use bags or direct values, while PDFs are expected to follow the XMP standard and ignore # the plain Dublin Core variant. For this reason, add a fallback here to deal with such # issues accordingly. retval.extend(bags) else: value = converter(self._get_text(element)) retval.append(value) ns_cache = self.cache.setdefault(namespace, {}) ns_cache[name] = retval return retval def _get_langalt_values(self, namespace: str, name: str) -> Optional[dict[Any, Any]]: cached = self.cache.get(namespace, {}).get(name) if cached: return cached retval: dict[Any, Any] = {} for element in self.get_element("", namespace, name): alts = element.getElementsByTagNameNS(RDF_NAMESPACE, "Alt") if len(alts): for alt in alts: for item in alt.getElementsByTagNameNS(RDF_NAMESPACE, "li"): value = self._get_text(item) retval[item.getAttribute("xml:lang")] = value else: retval["x-default"] = self._get_text(element) ns_cache = self.cache.setdefault(namespace, {}) ns_cache[name] = retval return retval @property def dc_contributor(self) -> Optional[list[str]]: """Contributors to the resource (other than the authors).""" return self._getter_bag(DC_NAMESPACE, "contributor") @dc_contributor.setter def dc_contributor(self, values: Optional[list[str]]) -> None: self._set_bag_values(DC_NAMESPACE, "contributor", values) @property def dc_coverage(self) -> Optional[str]: """Text describing the extent or scope of the resource.""" return self._get_single_value(DC_NAMESPACE, "coverage") @dc_coverage.setter def dc_coverage(self, value: Optional[str]) -> None: self._set_single_value(DC_NAMESPACE, "coverage", value) @property def dc_creator(self) -> Optional[list[str]]: """A sorted array of names of the authors of the resource, listed in order of precedence.""" return self._get_seq_values(DC_NAMESPACE, "creator") @dc_creator.setter def dc_creator(self, values: Optional[list[str]]) -> None: self._set_seq_values(DC_NAMESPACE, "creator", values) @property def dc_date(self) -> Optional[list[datetime.datetime]]: """A sorted array of dates of significance to the resource. The dates and times are in UTC.""" return self._get_seq_values(DC_NAMESPACE, "date", _converter_date) @dc_date.setter def dc_date(self, values: Optional[list[Union[str, datetime.datetime]]]) -> None: if values is None: self._set_seq_values(DC_NAMESPACE, "date", None) else: date_strings = [] for value in values: if isinstance(value, datetime.datetime): date_strings.append(_format_datetime_utc(value)) else: date_strings.append(str(value)) self._set_seq_values(DC_NAMESPACE, "date", date_strings) @property def dc_description(self) -> Optional[dict[str, str]]: """A language-keyed dictionary of textual descriptions of the content of the resource.""" return self._get_langalt_values(DC_NAMESPACE, "description") @dc_description.setter def dc_description(self, values: Optional[dict[str, str]]) -> None: self._set_langalt_values(DC_NAMESPACE, "description", values) @property def dc_format(self) -> Optional[str]: """The mime-type of the resource.""" return self._get_single_value(DC_NAMESPACE, "format") @dc_format.setter def dc_format(self, value: Optional[str]) -> None: self._set_single_value(DC_NAMESPACE, "format", value) @property def dc_identifier(self) -> Optional[str]: """Unique identifier of the resource.""" return self._get_single_value(DC_NAMESPACE, "identifier") @dc_identifier.setter def dc_identifier(self, value: Optional[str]) -> None: self._set_single_value(DC_NAMESPACE, "identifier", value) @property def dc_language(self) -> Optional[list[str]]: """An unordered array specifying the languages used in the resource.""" return self._getter_bag(DC_NAMESPACE, "language") @dc_language.setter def dc_language(self, values: Optional[list[str]]) -> None: self._set_bag_values(DC_NAMESPACE, "language", values) @property def dc_publisher(self) -> Optional[list[str]]: """An unordered array of publisher names.""" return self._getter_bag(DC_NAMESPACE, "publisher") @dc_publisher.setter def dc_publisher(self, values: Optional[list[str]]) -> None: self._set_bag_values(DC_NAMESPACE, "publisher", values) @property def dc_relation(self) -> Optional[list[str]]: """An unordered array of text descriptions of relationships to other documents.""" return self._getter_bag(DC_NAMESPACE, "relation") @dc_relation.setter def dc_relation(self, values: Optional[list[str]]) -> None: self._set_bag_values(DC_NAMESPACE, "relation", values) @property def dc_rights(self) -> Optional[dict[str, str]]: """A language-keyed dictionary of textual descriptions of the rights the user has to this resource.""" return self._get_langalt_values(DC_NAMESPACE, "rights") @dc_rights.setter def dc_rights(self, values: Optional[dict[str, str]]) -> None: self._set_langalt_values(DC_NAMESPACE, "rights", values) @property def dc_source(self) -> Optional[str]: """Unique identifier of the work from which this resource was derived.""" return self._get_single_value(DC_NAMESPACE, "source") @dc_source.setter def dc_source(self, value: Optional[str]) -> None: self._set_single_value(DC_NAMESPACE, "source", value) @property def dc_subject(self) -> Optional[list[str]]: """An unordered array of descriptive phrases or keywords that specify the topic of the content.""" return self._getter_bag(DC_NAMESPACE, "subject") @dc_subject.setter def dc_subject(self, values: Optional[list[str]]) -> None: self._set_bag_values(DC_NAMESPACE, "subject", values) @property def dc_title(self) -> Optional[dict[str, str]]: """A language-keyed dictionary of the title of the resource.""" return self._get_langalt_values(DC_NAMESPACE, "title") @dc_title.setter def dc_title(self, values: Optional[dict[str, str]]) -> None: self._set_langalt_values(DC_NAMESPACE, "title", values) @property def dc_type(self) -> Optional[list[str]]: """An unordered array of textual descriptions of the document type.""" return self._getter_bag(DC_NAMESPACE, "type") @dc_type.setter def dc_type(self, values: Optional[list[str]]) -> None: self._set_bag_values(DC_NAMESPACE, "type", values) @property def pdf_keywords(self) -> Optional[str]: """An unformatted text string representing document keywords.""" return self._get_single_value(PDF_NAMESPACE, "Keywords") @pdf_keywords.setter def pdf_keywords(self, value: Optional[str]) -> None: self._set_single_value(PDF_NAMESPACE, "Keywords", value) @property def pdf_pdfversion(self) -> Optional[str]: """The PDF file version, for example 1.0 or 1.3.""" return self._get_single_value(PDF_NAMESPACE, "PDFVersion") @pdf_pdfversion.setter def pdf_pdfversion(self, value: Optional[str]) -> None: self._set_single_value(PDF_NAMESPACE, "PDFVersion", value) @property def pdf_producer(self) -> Optional[str]: """The name of the tool that saved the document as a PDF.""" return self._get_single_value(PDF_NAMESPACE, "Producer") @pdf_producer.setter def pdf_producer(self, value: Optional[str]) -> None: self._set_single_value(PDF_NAMESPACE, "Producer", value) @property def xmp_create_date(self) -> Optional[datetime.datetime]: """The date and time the resource was originally created. Returned as a UTC datetime object.""" return self._get_single_value(XMP_NAMESPACE, "CreateDate", _converter_date) @xmp_create_date.setter def xmp_create_date(self, value: Optional[datetime.datetime]) -> None: if value: date_str = _format_datetime_utc(value) self._set_single_value(XMP_NAMESPACE, "CreateDate", date_str) else: self._set_single_value(XMP_NAMESPACE, "CreateDate", None) @property def xmp_modify_date(self) -> Optional[datetime.datetime]: """The date and time the resource was last modified. Returned as a UTC datetime object.""" return self._get_single_value(XMP_NAMESPACE, "ModifyDate", _converter_date) @xmp_modify_date.setter def xmp_modify_date(self, value: Optional[datetime.datetime]) -> None: if value: date_str = _format_datetime_utc(value) self._set_single_value(XMP_NAMESPACE, "ModifyDate", date_str) else: self._set_single_value(XMP_NAMESPACE, "ModifyDate", None) @property def xmp_metadata_date(self) -> Optional[datetime.datetime]: """The date and time that any metadata for this resource was last changed. Returned as a UTC datetime object.""" return self._get_single_value(XMP_NAMESPACE, "MetadataDate", _converter_date) @xmp_metadata_date.setter def xmp_metadata_date(self, value: Optional[datetime.datetime]) -> None: if value: date_str = _format_datetime_utc(value) self._set_single_value(XMP_NAMESPACE, "MetadataDate", date_str) else: self._set_single_value(XMP_NAMESPACE, "MetadataDate", None) @property def xmp_creator_tool(self) -> Optional[str]: """The name of the first known tool used to create the resource.""" return self._get_single_value(XMP_NAMESPACE, "CreatorTool") @xmp_creator_tool.setter def xmp_creator_tool(self, value: Optional[str]) -> None: self._set_single_value(XMP_NAMESPACE, "CreatorTool", value) @property def xmpmm_document_id(self) -> Optional[str]: """The common identifier for all versions and renditions of this resource.""" return self._get_single_value(XMPMM_NAMESPACE, "DocumentID") @xmpmm_document_id.setter def xmpmm_document_id(self, value: Optional[str]) -> None: self._set_single_value(XMPMM_NAMESPACE, "DocumentID", value) @property def xmpmm_instance_id(self) -> Optional[str]: """An identifier for a specific incarnation of a document, updated each time a file is saved.""" return self._get_single_value(XMPMM_NAMESPACE, "InstanceID") @xmpmm_instance_id.setter def xmpmm_instance_id(self, value: Optional[str]) -> None: self._set_single_value(XMPMM_NAMESPACE, "InstanceID", value) @property def pdfaid_part(self) -> Optional[str]: """The part of the PDF/A standard that the document conforms to (e.g., 1, 2, 3).""" return self._get_single_value(PDFAID_NAMESPACE, "part") @pdfaid_part.setter def pdfaid_part(self, value: Optional[str]) -> None: self._set_single_value(PDFAID_NAMESPACE, "part", value) @property def pdfaid_conformance(self) -> Optional[str]: """The conformance level within the PDF/A standard (e.g., 'A', 'B', 'U').""" return self._get_single_value(PDFAID_NAMESPACE, "conformance") @pdfaid_conformance.setter def pdfaid_conformance(self, value: Optional[str]) -> None: self._set_single_value(PDFAID_NAMESPACE, "conformance", value) @property def custom_properties(self) -> dict[Any, Any]: """ Retrieve custom metadata properties defined in the undocumented pdfx metadata schema. Returns: A dictionary of key/value items for custom metadata properties. """ if not hasattr(self, "_custom_properties"): self._custom_properties = {} for node in self.get_nodes_in_namespace("", PDFX_NAMESPACE): key = node.localName while True: # see documentation about PDFX_NAMESPACE earlier in file idx = key.find("\u2182") if idx == -1: break key = ( key[:idx] + chr(int(key[idx + 1 : idx + 5], base=16)) + key[idx + 5 :] ) if node.nodeType == node.ATTRIBUTE_NODE: value = node.nodeValue else: value = self._get_text(node) self._custom_properties[key] = value return self._custom_properties def _get_or_create_description(self, about_uri: str = "") -> XmlElement: """Get or create an rdf:Description element with the given about URI.""" for desc in self.rdf_root.getElementsByTagNameNS(RDF_NAMESPACE, "Description"): if desc.getAttributeNS(RDF_NAMESPACE, "about") == about_uri: return desc doc = self.rdf_root.ownerDocument if doc is None: raise XmpDocumentError("XMP Document is None") desc = doc.createElementNS(RDF_NAMESPACE, "rdf:Description") desc.setAttributeNS(RDF_NAMESPACE, "rdf:about", about_uri) self.rdf_root.appendChild(desc) return desc def _clear_cache_entry(self, namespace: str, name: str) -> None: """Remove a cached value for a given namespace/name if present.""" ns_cache = self.cache.get(namespace) if ns_cache and name in ns_cache: del ns_cache[name] def _set_single_value(self, namespace: str, name: str, value: Optional[str]) -> None: """Set or remove a single metadata value.""" self._clear_cache_entry(namespace, name) desc = self._get_or_create_description() existing_elements = list(desc.getElementsByTagNameNS(namespace, name)) for elem in existing_elements: desc.removeChild(elem) if existing_attr := desc.getAttributeNodeNS(namespace, name): desc.removeAttributeNode(existing_attr) if value is not None: doc = self.rdf_root.ownerDocument if doc is None: raise XmpDocumentError("XMP Document is None") prefix = self._get_namespace_prefix(namespace) elem = doc.createElementNS(namespace, f"{prefix}:{name}") text_node = doc.createTextNode(str(value)) elem.appendChild(text_node) desc.appendChild(elem) self._update_stream() def _set_bag_values(self, namespace: str, name: str, values: Optional[list[str]]) -> None: """Set or remove bag values (unordered array).""" self._clear_cache_entry(namespace, name) desc = self._get_or_create_description() existing_elements = list(desc.getElementsByTagNameNS(namespace, name)) for elem in existing_elements: desc.removeChild(elem) if values: doc = self.rdf_root.ownerDocument if doc is None: raise XmpDocumentError("XMP Document is None") prefix = self._get_namespace_prefix(namespace) elem = doc.createElementNS(namespace, f"{prefix}:{name}") bag = doc.createElementNS(RDF_NAMESPACE, "rdf:Bag") for value in values: li = doc.createElementNS(RDF_NAMESPACE, "rdf:li") text_node = doc.createTextNode(str(value)) li.appendChild(text_node) bag.appendChild(li) elem.appendChild(bag) desc.appendChild(elem) self._update_stream() def _set_seq_values(self, namespace: str, name: str, values: Optional[list[str]]) -> None: """Set or remove sequence values (ordered array).""" self._clear_cache_entry(namespace, name) desc = self._get_or_create_description() existing_elements = list(desc.getElementsByTagNameNS(namespace, name)) for elem in existing_elements: desc.removeChild(elem) if values: doc = self.rdf_root.ownerDocument if doc is None: raise XmpDocumentError("XMP Document is None") prefix = self._get_namespace_prefix(namespace) elem = doc.createElementNS(namespace, f"{prefix}:{name}") seq = doc.createElementNS(RDF_NAMESPACE, "rdf:Seq") for value in values: li = doc.createElementNS(RDF_NAMESPACE, "rdf:li") text_node = doc.createTextNode(str(value)) li.appendChild(text_node) seq.appendChild(li) elem.appendChild(seq) desc.appendChild(elem) self._update_stream() def _set_langalt_values(self, namespace: str, name: str, values: Optional[dict[str, str]]) -> None: """Set or remove language alternative values.""" self._clear_cache_entry(namespace, name) desc = self._get_or_create_description() existing_elements = list(desc.getElementsByTagNameNS(namespace, name)) for elem in existing_elements: desc.removeChild(elem) if values: doc = self.rdf_root.ownerDocument if doc is None: raise XmpDocumentError("XMP Document is None") prefix = self._get_namespace_prefix(namespace) elem = doc.createElementNS(namespace, f"{prefix}:{name}") alt = doc.createElementNS(RDF_NAMESPACE, "rdf:Alt") for lang, value in values.items(): li = doc.createElementNS(RDF_NAMESPACE, "rdf:li") li.setAttribute("xml:lang", lang) text_node = doc.createTextNode(str(value)) li.appendChild(text_node) alt.appendChild(li) elem.appendChild(alt) desc.appendChild(elem) self._update_stream() def _get_namespace_prefix(self, namespace: str) -> str: """Get the appropriate namespace prefix for a given namespace URI.""" return _NAMESPACE_PREFIX_MAP.get(namespace, "unknown") def _update_stream(self) -> None: """Update the stream with the current XML content.""" doc = self.rdf_root.ownerDocument if doc is None: raise XmpDocumentError("XMP Document is None") xml_data = doc.toxml(encoding="utf-8") self.stream.set_data(xml_data) pypdf-6.1.2/pyproject.toml000066400000000000000000000217721507516550200155750ustar00rootroot00000000000000[build-system] requires = ["flit_core >=3.11,<4"] build-backend = "flit_core.buildapi" [project] name = "pypdf" authors = [{ name = "Mathieu Fenniak", email = "biziqe@mathieu.fenniak.net" }] maintainers = [{ name = "stefan6419846" }, { name = "Martin Thoma", email = "info@martin-thoma.de" }] description = "A pure-python PDF library capable of splitting, merging, cropping, and transforming PDF files" readme = "README.md" dynamic = ["version"] license = "BSD-3-Clause" license-files = ["LICENSE"] requires-python = ">=3.9" classifiers = [ "Development Status :: 5 - Production/Stable", "Intended Audience :: Developers", "Programming Language :: Python :: 3", "Programming Language :: Python :: 3 :: Only", "Programming Language :: Python :: 3.9", "Programming Language :: Python :: 3.10", "Programming Language :: Python :: 3.11", "Programming Language :: Python :: 3.12", "Programming Language :: Python :: 3.13", "Programming Language :: Python :: 3.14", "Operating System :: OS Independent", "Topic :: Software Development :: Libraries :: Python Modules", "Typing :: Typed", ] dependencies = [ "typing_extensions >= 4.0; python_version < '3.11'", ] [project.urls] Changelog = "https://pypdf.readthedocs.io/en/latest/meta/CHANGELOG.html" Documentation = "https://pypdf.readthedocs.io/en/latest/" Source = "https://github.com/py-pdf/pypdf" "Bug Reports" = "https://github.com/py-pdf/pypdf/issues" [project.optional-dependencies] crypto = ["cryptography"] cryptodome = ["PyCryptodome"] image = ["Pillow>=8.0.0"] full = [ "cryptography", "Pillow>=8.0.0" ] dev = [ "black", "flit", "pip-tools", "pre-commit", "pytest-cov", "pytest-socket", "pytest-timeout", "pytest-xdist", "wheel" ] docs = [ "myst_parser", "sphinx", "sphinx_rtd_theme" ] [tool.check-wheel-contents] package = "./pypdf" [tool.flit.sdist] exclude = [ ".gitblame-ignore-revs", ".github/*", ".gitignore", ".gitmodules", ".pre-commit-config.yaml", "docs/*", "make_release.py", "Makefile", "requirements/*", "sample-files/.github/*", "sample-files/.gitignore", "sample-files/.pre-commit-config.yaml", "tests/pdf_cache/*", ] include = ["resources/", "tests/", "CHANGELOG.md"] [tool.pytest.ini_options] addopts = "--disable-socket" filterwarnings = ["error"] markers = [ "slow: Test which require more than a second", "samples: Tests which use files from https://github.com/py-pdf/sample-files", "enable_socket: Tests which need to download files" ] testpaths = ["tests"] norecursedirs = ["tests/pdf_cache"] [tool.isort] line_length = 79 indent = ' ' multi_line_output = 3 include_trailing_comma = true known_third_party = ["pytest", "setuptools"] [tool.coverage.run] source = ["pypdf"] branch = true [tool.coverage.report] # Regexes for lines to exclude from consideration exclude_lines = [ # Have to re-enable the standard pragma "pragma: no cover", "@overload", "deprecated", # Don't complain about type-checking code not being hit by unit tests "if TYPE_CHECKING", # Don't complain about missing debug-only code: "def __repr__", "def __str__", "if self\\.debug", # Don't complain if tests don't hit defensive assertion code: "raise AssertionError", "raise NotImplementedError", # Don't complain if non-runnable code isn't run: "if __name__ == .__main__.:", ] [tool.ruff] line-length = 120 [tool.ruff.lint] select = ["ALL"] ignore = [ "A001", # Variable is shadowing a Python builtin "A002", # Function argument is shadowing a Python builtin "ANN401", # Dynamically typed expressions (typing.Any) are disallowed "ARG001", # Unused function argument "ARG002", # Unused method argument "ARG004", # Unused static method argument "B904", # Within an `except` clause, raise exceptions with "B905", # `zip()` without an explicit `strict=` parameter "BLE001", # Do not catch blind exception: `Exception` "COM812", # Yes, they make the diff smaller "D101", # Missing docstring in public class "D102", # Missing docstring in public method "D105", # Missing docstring in magic method "D106", # Missing docstring in public nested class "D107", # Missing docstring in `__init__` "D205", # One blank line required between summary line and description "D212", # I want multiline-docstrings to start at the second line "D401", # First line of docstring should be in imperative mood - false positives "D415", # First line should end with a period "D417", # Missing argument descriptions in the docstring "DTZ001", # The use of `datetime.datetime()` without `tzinfo` is necessary "EM101", # Exception must not use a string literal, assign to variable first "EM102", # Exception must not use an f-string literal, assign to variable first "ERA001", # Found commented-out code "FA100", # Missing `from __future__ import annotations`, but uses `typing.Dict` "FA102", # Missing `from __future__ import annotations`, but uses PEP 604 union "FBT001", # Boolean positional arg in function definition "FBT002", # Boolean default value in function definition "FBT003", # Boolean positional value in function call "FIX002", # TODOs should typically not be in the code, but sometimes are ok "G004", # f-string in logging statement "N806", # non-lowercase-variable-in-function "N814", # Camelcase `PageAttributes` imported as constant `PG` "N817", # CamelCase `PagesAttributes` imported as acronym `PA` "PERF203", # `try`-`except` within a loop incurs performance overhead "PGH003", # Use specific rule codes when ignoring type issues "PLW1510", # `subprocess.run` without explicit `check` argument "PLW2901", # `with` statement variable `img` overwritten by assignment target "PT011", # `pytest.raises(ValueError)` is too broad, set the `match` "PT012", # `pytest.raises()` block should contain a single simple statement "PT014", # Ruff bug: Duplicate of test case at index 1 in `@pytest_mark.parametrize` "PTH123", # `open()` should be replaced by `Path.open()` "PYI042", # Type alias `mode_str_type` should be CamelCase "RET503", # Missing explicit `return` at the end of function able to return non-`None` value "RUF001", # Detect confusable Unicode-to-Unicode units. Introduces bugs "RUF002", # Detect confusable Unicode-to-Unicode units. Introduces bugs "S101", # Use of `assert` detected "S110", # `try`-`except`-`pass` detected, consider logging the exception "SIM105", # contextlib.suppress "SIM108", # Don't enforce ternary operators "SLF001", # Private member accessed "TC006", # To discuss: Add quotes to type expression in `typing.cast()` "TD002", # Authors of TODOs can be found via git "TD003", # For the moment, fix it later: Missing issue link on the line following this TODO "TID252", # We want relative imports "TRY002", # Create your own exception "TRY003", # Avoid specifying long messages outside the exception class "TRY004", # Prefer `TypeError` exception for invalid type "TRY201", # Use `raise` without specifying exception name "TRY300", # Consider moving this statement to an `else` block "TRY301", # Abstract `raise` to an inner function "UP006", # Non-PEP 585 annotation. As long as we are not on Python 3.11+ "UP007", # Non-PEP 604 annotation. As long as we are not on Python 3.11+ ] [tool.ruff.lint.mccabe] max-complexity = 37 # Recommended: 10 [tool.ruff.lint.per-file-ignores] "_cryptography.py" = ["S304", "S305"] # Use of insecure cipher / modes, aka RC4 and AES-ECB "_encryption.py" = ["S324"] "_writer.py" = ["S324"] "pypdf/_codecs/symbol.py" = ["A005"] # Module shadows a Python standard-library module "types.py" = ["A005"] # Module shadows a Python standard-library module "pypdf/_text_extraction/__init__.py" = ["PLW0603"] # Using the global statement to update is discouraged "docs/conf.py" = ["INP001", "PTH100"] "json_consistency.py" = ["T201"] "make_release.py" = ["S603", "S607", "T201"] "pypdf/*" = ["N802", "N803"] # We first need to deprecate old stuff "sample-files/*" = ["D100", "INP001"] "tests/*" = ["ANN001", "ANN201", "B017", "B018", "D103", "D104", "S105", "S106"] "tests/test_workflows.py" = ["T201"] [tool.ruff.lint.pydocstyle] convention = "google" [tool.ruff.lint.pylint] allow-magic-value-types = ["bytes", "float", "int", "str"] max-args = 12 # Recommended: 5 max-branches = 36 # Recommended: 12 max-returns = 11 # Recommended: 6 max-statements = 176 # Recommended: 50 [tool.docformatter] pre-summary-newline = true wrap-summaries = 0 wrap-descriptions = 0 [tool.mypy] show_error_codes = true ignore_missing_imports = true check_untyped_defs = true disallow_any_generics = true disallow_untyped_defs = true disallow_incomplete_defs = true warn_redundant_casts = true warn_unused_ignores = true warn_unused_configs = true exclude = ['venv', '.venv', 'tests', 'make_release.py'] pypdf-6.1.2/requirements/000077500000000000000000000000001507516550200153735ustar00rootroot00000000000000pypdf-6.1.2/requirements/ci-3.11.txt000066400000000000000000000031271507516550200171120ustar00rootroot00000000000000# # This file is autogenerated by pip-compile with Python 3.11 # by the following command: # # pip-compile --output-file=requirements/ci-3.11.txt requirements/ci.in # cffi==1.17.1 # via cryptography coverage[toml]==7.10.1 # via # -r requirements/ci.in # pytest-cov cryptography==44.0.1 # via -r requirements/ci.in defusedxml==0.7.1 # via fpdf2 exceptiongroup==1.2.2 # via pytest execnet==2.1.1 # via pytest-xdist fonttools==4.54.1 # via fpdf2 fpdf2==2.8.1 # via -r requirements/ci.in iniconfig==2.0.0 # via pytest mypy==1.17.0 # via -r requirements/ci.in mypy-extensions==1.0.0 # via mypy packaging==24.1 # via pytest pillow==11.3.0 # via # -r requirements/ci.in # fpdf2 pluggy==1.5.0 # via pytest py-cpuinfo==9.0.0 # via pytest-benchmark pycparser==2.22 # via cffi pytest==8.3.3 # via # -r requirements/ci.in # pytest-benchmark # pytest-cov # pytest-socket # pytest-timeout # pytest-xdist pytest-benchmark==4.0.0 # via -r requirements/ci.in pytest-cov==5.0.0 # via -r requirements/ci.in pytest-socket==0.7.0 # via -r requirements/ci.in pytest-timeout==2.3.1 # via -r requirements/ci.in pytest-xdist==3.6.1 # via -r requirements/ci.in pyyaml==6.0.2 # via -r requirements/ci.in ruff==0.13.0 # via -r requirements/ci.in tomli==2.0.2 # via # coverage # mypy # pytest typeguard==4.3.0 # via -r requirements/ci.in types-pillow==10.2.0.20240822 # via -r requirements/ci.in typing-extensions==4.12.2 # via # mypy # typeguard pypdf-6.1.2/requirements/ci.in000066400000000000000000000002651507516550200163210ustar00rootroot00000000000000coverage fpdf2 mypy pillow cryptography pytest pytest-benchmark pytest-socket pytest-timeout pytest-xdist pytest-cov # ruff # only take this for 3.11 typeguard types-Pillow pyyaml pypdf-6.1.2/requirements/ci.txt000066400000000000000000000031311507516550200165250ustar00rootroot00000000000000# # This file is autogenerated by pip-compile with Python 3.8 # by the following command: # # pip-compile requirements/ci.in # cffi==1.17.1 # via cryptography coverage[toml]==7.6.1 # via # -r requirements/ci.in # pytest-cov cryptography==44.0.1 # via -r requirements/ci.in defusedxml==0.7.1 # via fpdf2 exceptiongroup==1.2.2 # via pytest execnet==2.1.1 # via pytest-xdist fonttools==4.54.1 # via fpdf2 fpdf2==2.8.1 # via -r requirements/ci.in importlib-metadata==8.5.0 # via typeguard iniconfig==2.0.0 # via pytest mypy==1.13.0 # via -r requirements/ci.in mypy-extensions==1.0.0 # via mypy packaging==24.1 # via pytest pillow==10.4.0 # via # -r requirements/ci.in # fpdf2 pluggy==1.5.0 # via pytest py-cpuinfo==9.0.0 # via pytest-benchmark pycparser==2.22 # via cffi pytest==8.3.3 # via # -r requirements/ci.in # pytest-benchmark # pytest-cov # pytest-socket # pytest-timeout # pytest-xdist pytest-benchmark==4.0.0 # via -r requirements/ci.in pytest-cov==5.0.0 # via -r requirements/ci.in pytest-socket==0.7.0 # via -r requirements/ci.in pytest-timeout==2.3.1 # via -r requirements/ci.in pytest-xdist==3.6.1 # via -r requirements/ci.in pyyaml==6.0.2 # via -r requirements/ci.in tomli==2.0.2 # via # coverage # mypy # pytest typeguard==4.3.0 # via -r requirements/ci.in types-pillow==10.2.0.20240822 # via -r requirements/ci.in typing-extensions==4.12.2 # via # mypy # typeguard zipp==3.20.2 # via importlib-metadata pypdf-6.1.2/requirements/dev.in000066400000000000000000000000621507516550200164770ustar00rootroot00000000000000pillow pip-tools pre-commit pytest-cov flit wheel pypdf-6.1.2/requirements/dev.txt000066400000000000000000000031771507516550200167220ustar00rootroot00000000000000# # This file is autogenerated by pip-compile with Python 3.8 # by the following command: # # pip-compile requirements/dev.in # build==1.2.2.post1 # via pip-tools certifi==2024.8.30 # via requests cfgv==3.4.0 # via pre-commit charset-normalizer==3.4.0 # via requests click==8.1.7 # via pip-tools coverage[toml]==7.6.1 # via pytest-cov distlib==0.3.9 # via virtualenv docutils==0.20.1 # via flit exceptiongroup==1.2.2 # via pytest filelock==3.16.1 # via virtualenv flit==3.11.0 # via -r requirements/dev.in flit-core==3.11.0 # via flit identify==2.6.1 # via pre-commit idna==3.10 # via requests importlib-metadata==8.5.0 # via build iniconfig==2.0.0 # via pytest nodeenv==1.9.1 # via pre-commit packaging==24.1 # via # build # pytest pillow==10.4.0 # via -r requirements/dev.in pip-tools==7.4.1 # via -r requirements/dev.in platformdirs==4.3.6 # via virtualenv pluggy==1.5.0 # via pytest pre-commit==3.5.0 # via -r requirements/dev.in pyproject-hooks==1.2.0 # via # build # pip-tools pytest==8.3.3 # via pytest-cov pytest-cov==5.0.0 # via -r requirements/dev.in pyyaml==6.0.2 # via pre-commit requests==2.32.4 # via flit tomli==2.0.2 # via # build # coverage # pip-tools # pytest tomli-w==1.0.0 # via flit urllib3==2.5.0 # via requests virtualenv==20.27.0 # via pre-commit wheel==0.44.0 # via # -r requirements/dev.in # pip-tools zipp==3.20.2 # via importlib-metadata # The following packages are considered to be unsafe in a requirements file: # pip # setuptools pypdf-6.1.2/requirements/docs.in000066400000000000000000000000441507516550200166510ustar00rootroot00000000000000sphinx sphinx_rtd_theme myst_parser pypdf-6.1.2/requirements/docs.txt000066400000000000000000000027411507516550200170700ustar00rootroot00000000000000# # This file is autogenerated by pip-compile with Python 3.10 # by the following command: # # pip-compile requirements/docs.in # alabaster==1.0.0 # via sphinx babel==2.16.0 # via sphinx certifi==2024.8.30 # via requests charset-normalizer==3.4.0 # via requests docutils==0.21.2 # via # myst-parser # sphinx # sphinx-rtd-theme idna==3.10 # via requests imagesize==1.4.1 # via sphinx jinja2==3.1.6 # via # myst-parser # sphinx markdown-it-py==3.0.0 # via # mdit-py-plugins # myst-parser markupsafe==3.0.1 # via jinja2 mdit-py-plugins==0.4.2 # via myst-parser mdurl==0.1.2 # via markdown-it-py myst-parser==4.0.0 # via -r requirements/docs.in packaging==24.1 # via sphinx pygments==2.18.0 # via sphinx pyyaml==6.0.2 # via myst-parser requests==2.32.4 # via sphinx snowballstemmer==2.2.0 # via sphinx sphinx==8.1.3 # via # -r requirements/docs.in # myst-parser # sphinx-rtd-theme # sphinxcontrib-jquery sphinx-rtd-theme==3.0.1 # via -r requirements/docs.in sphinxcontrib-applehelp==2.0.0 # via sphinx sphinxcontrib-devhelp==2.0.0 # via sphinx sphinxcontrib-htmlhelp==2.1.0 # via sphinx sphinxcontrib-jquery==4.1 # via sphinx-rtd-theme sphinxcontrib-jsmath==1.0.1 # via sphinx sphinxcontrib-qthelp==2.0.0 # via sphinx sphinxcontrib-serializinghtml==2.0.0 # via sphinx tomli==2.0.2 # via sphinx urllib3==2.5.0 # via requests pypdf-6.1.2/resources/000077500000000000000000000000001507516550200146625ustar00rootroot00000000000000pypdf-6.1.2/resources/010-pdflatex-forms.txt000066400000000000000000000002121507516550200206470ustar00rootroot00000000000000Name Check Submit 1pypdf-6.1.2/resources/AEO.1172.layout.rot180.txt000066400000000000000000000040101507516550200207630ustar00rootroot000000000000009 1of Page 2022 AEO Management Co. All Rights Reserved. Proprietary and Confidential AEO Business Information. Subject to Legal Action if Disclosed Without Authorization from AEO.Date Printed: 17/Nov/2022 PRODUCT SUMMARY Fit / Other: 1172 KNIT SHORTIE Style Desc: SUMMER-B 2023 Season: 50 / 170 Division / Dept: AMERICAN EAGLE OUTFITTERSCompany: SUMMER-B 2023 1172 KNIT SHORTIE STYLE: 1172 STATUS: FNL pypdf-6.1.2/resources/AEO.1172.layout.txt000066400000000000000000000021271507516550200177360ustar00rootroot00000000000000 STATUS: FNL STYLE: 1172 1172 KNIT SHORTIE SUMMER-B 2023 Company: AMERICAN EAGLE OUTFITTERS Division / Dept: 50 / 170 Season: SUMMER-B 2023 Style Desc: 1172 KNIT SHORTIE Fit / Other: PRODUCT SUMMARY Date Printed: 17/Nov/2022 2022 AEO Management Co. All Rights Reserved. Proprietary and Confidential AEO Business Information. Subject to Legal Action if Disclosed Without Authorization from AEO. 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An On Hold / Missing New doc info was Leave state as On Batches can be released early Documents case receives its logged but no Hold and update state and coders can code all they can first documentation set after further automated reason to Ready To and then leave the batch in In coding operations have action was taken. Code. Progress. When docs come in, already begun for the batch the case is picked up by the (batch state = In Progress). normal On Hold process due to the assignment of the Ready to Code state reason. An “incomplete” case (not All documents All manually attached Ensures that ALL info that has Code Completed or Ignored) were “overwritten” PDFs are preserved arrived for the case remains in an “in flight” batch (state = with data from the in place and all visible to users. Specifically Reconciled, Assigned, or In new documents. “extracted” addresses split labor / C-section Progress) receives new documents are cases, allowing a coder to refer documents. aggregated under a back to the “Superseded” SUPERSEDED ON documents to make sure a newly [DATE] text doc with extracted “C-section only” type Complete document wasn’t really a Labor Record. to C-section case. New documents are received New doc info was Existing documents Prompts the coder to review the for a Code Completed or logged but no are “superseded” new documentation set while Ignored case in an “in flight” further automated (see previous) and retaining all previously applied batch. action was taken. the case is set back codes. If no significant change is to On Hold / Ready to noted, the case can simply be set Code. back to Code Completed. Documentation for an New case info The case is added to Ensures proper review of any “uncoded” (aka not Code was logged but a new batch with the additional documentation Completed) case or a new no further same date of service. received for a previously patient is received for a automated action Set state to Ignored completed batch as well as Complete or Charges Entered was taken. on the original case (if documentation for brand new batch. it exists) and add cases after a batch has already notes to both the been Completed. Notes on the original and new original and duplicate case cases indicating the ensure that users are aware of link between the two. actions taken by the system. Documentation for a Code New doc info was Existing case The status of the new document Completed case in a logged but no documents are left in is clearly indicated as arriving Complete or Charges Entered further automated place and the new AFTER the associated case was batch is received. action was taken. documentation is coded avoiding potential added as a PDF confusion regarding which attachment with type documentation was utilized at the “complete record” and time of coding while also title POSTED LATE - providing access to the new info [DATE]. and allowing the end user to determine the correct course of action.pypdf-6.1.2/resources/Epic.Page.layout.txt000066400000000000000000000020401507516550200204660ustar00rootroot00000000000000All Postprocedure Notes Last edited 10/11/23 0919 by Danny Chaung, DO Date of Service 10/11/23 0918 Status: Signed Anesthesia Post Evaluation Procedure Summary Date: 10/11/23 Room / Location: EHMC ENDOSCOPY Anesthesia Start: 0852 Anesthesia Stop: 0918 Procedure: COLONOSCOPY Diagnosis: Cancer screening Scheduled Providers: Walter A Klein, MD; Danny Chaung, Responsible Provider: Danny Chaung, DO DO Anesthesia Type: general ASA Status: 2 Patient location during evaluation: PACU Post op Vital Signs: stable Level of consciousness: awake and alert Pain management: adequate analgesia Airway patency: patent Anesthetic complications: no Respiratory status: unassisted Hydration status: continuing Post-op Complications: No Assessment: Nausea and Vomiting: absent MIPS Measure #404 - Smoking Abstinence Is the patient a current smoker? 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This is available in two fields: "Comment" and "Notice". # However, all information available in "Comment" is also available in "Notice", and # the information under "Notice" is more complete. Ignore "Comment" and only copy # information from "Notice", to avoid adding the same information twice. if key == "Notice" and value.startswith("Copyright"): copyrights.append(re.sub(r"\.([A-Z])", r". \1", value)) # Take care of missing space after period. if key == "C": # C integer ; WX number ; N name; We're ignoring C. key_value_pairs = line.split(";") character_width_x = -1 character_name = "dummy" for pair in key_value_pairs: if not pair.strip(): continue key_of_pair, value_of_pair = pair.strip().split(" ", maxsplit=1) if key_of_pair == "WX": character_width_x = int(value_of_pair) if key_of_pair == "N": character_name = value_of_pair glyph = adobe_glyphs[f"/{character_name}"] character_widths[glyph.encode("unicode_escape").decode("utf-8")] = character_width_x if key == "CH": raise NotImplementedError(name, line) result = [ f" # Generated from {file_name}" ] for copyright_entry in sorted(set(copyrights)): result.extend(f" # {line}" for line in textwrap.wrap(text=copyright_entry, width=95)) result.append(f' "{name}": FontDescriptor(') result.append(f' name="{name}",') result.append(f' family="{family}",') result.append(f' weight="{weight}",') result.append(f" ascent={ascent},") result.append(f" descent={descent},") result.append(f" cap_height={cap_height},") result.append(f" x_height={x_height},") result.append(f" italic_angle={italic_angle},") result.append(f" flags={flags},") result.append(f" bbox=({', '.join(map(str, bbox))}),") result.append(" character_widths={") for character, width in character_widths.items(): d = '"' try: if ord(character) == 34: # Double quotation mark d = "'" except TypeError: pass result.append(f" {d}{character}{d}: {width},") result.append(" },") result.append(" ),") return result def get_font_data(self) -> str: data = [ "from pypdf._font import FontDescriptor\n\n" "CORE_FONT_METRICS: dict[str, FontDescriptor] = {", ] for name, font_data in self.files.items(): data.extend(self._handle_font(name, font_data)) data.append("}\n") return 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stream xÚ%ÇŃ @0„á»VQEě ű™Ĺ0ŤY*—{ůň˙Z ČčDŁÄLT@ÉDb|Ľ=Ëë¸]®•űçʢ…ç üś1 endstream endobj startxref 11160 %%EOF pypdf-6.1.2/resources/crazyones.txt000066400000000000000000000016061507516550200174430ustar00rootroot00000000000000The Crazy Ones October 14, 1998 Heres to the crazy ones. The misď¬ts. The rebels. The troublemakers. The round pegs in the square holes. The ones who see things differently. Theyre not fond of rules. And they have no respect for the status quo. You can quote them, disagree with them, glorify or vilify them. About the only thing you cant do is ignore them. Because they change things. They invent. They imagine. They heal. They explore. They create. They inspire. They push the human race forward. Maybe they have to be crazy. How else can you stare at an empty canvas and see a work of art? Or sit in silence and hear a song thats never been written? Or gaze at a red planet and see a laboratory on wheels? We make tools for these kinds of people. While some see them as the crazy ones, we see genius. Because the people who are crazy enough to think they can change the world, are the ones who do.pypdf-6.1.2/resources/crazyones_layout_vertical_space.txt000066400000000000000000000017331507516550200241050ustar00rootroot00000000000000The Crazy Ones October 14, 1998 Heres to the crazy ones. The misď¬ts. The rebels. The troublemakers. The round pegs in the square holes. The ones who see things differently. Theyre not fond of rules. And they have no respect for the status quo. You can quote them, disagree with them, glorify or vilify them. About the only thing you cant do is ignore them. Because they change things. They invent. They imagine. They heal. They explore. They create. They inspire. They push the human race forward. Maybe they have to be crazy. How else can you stare at an empty canvas and see a work of art? Or sit in silence and hear a song thats never been written? Or gaze at a red planet and see a laboratory on wheels? We make tools for these kinds of people. While some see them as the crazy ones, we see genius. Because the people who are crazy enough to think they can change the world, are the ones who do.pypdf-6.1.2/resources/crazyones_layout_vertical_space_font_height_weight.txt000066400000000000000000000017411507516550200300310ustar00rootroot00000000000000The Crazy Ones October 14, 1998 Heres to the crazy ones. The misď¬ts. The rebels. The troublemakers. The round pegs in the square holes. The ones who see things differently. Theyre not fond of rules. And they have no respect for the status quo. You can quote them, disagree with them, glorify or vilify them. About the only thing you cant do is ignore them. Because they change things. They invent. They imagine. They heal. They explore. They create. They inspire. They push the human race forward. Maybe they have to be crazy. How else can you stare at an empty canvas and see a work of art? Or sit in silence and hear a song thats never been written? Or gaze at a red planet and see a laboratory on wheels? We make tools for these kinds of people. While some see them as the crazy ones, we see genius. 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Tj ET EMC 0 0 0 SCN 1 w 4 M 24.044 34.11 743.912 84.008 re S 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 674.1672 420.1522 cm 0 0 m 52.818 0 l S Q q 1 0 0 1 565.3123 407.1522 cm 0 0 m 167.678 0 l S Q q 1 0 0 1 565.3123 394.1522 cm 0 0 m 83.337 0 l S Q q 1 0 0 1 589.5178 317.1522 cm 0 0 m 162.044 0 l S Q q 1 0 0 1 565.3123 304.1522 cm 0 0 m 81.831 0 l S Q q 1 0 0 1 589.3878 240.1522 cm 0 0 m 167.534 0 l S Q /Artifact <>BDC BT 0.93 0.112 0.142 scn /TT0 1 Tf -0.01 Tc 12 0 0 12 565.3123 505.4237 Tm [(Clinical T)55.3 (rials: )]TJ ET EMC /Artifact <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 12 0 0 12 647.9695 505.4237 Tm [(NCCN believes that)-9.9 ( )]TJ ET EMC /Artifact <>BDC BT 12 0 0 12 565.3123 492.4237 Tm [(the best management for any patient)-9.8 ( )]TJ ET EMC /Artifact <>BDC BT 12 0 0 12 565.3123 479.4237 Tm [(with cancer is in a clinical trial.)-9.9 ( )]TJ ET EMC /Artifact <>BDC BT 0 Tc 12 0 0 12 725.0489 479.4237 Tm ( )Tj ET EMC /Artifact <>BDC BT -0.01 Tc 12 0 0 12 565.3123 466.4237 Tm [(Participation in clinical trials is)-10 ( )]TJ ET EMC /Artifact <>BDC BT 12 0 0 12 565.3123 453.4237 Tm (especially encouraged.)Tj ET EMC /Artifact <>BDC BT /C2_0 1 Tf 0.01 Tw 12 0 0 12 565.3123 434.4237 Tm [<0037>111 <0052000300bf0051004700030046004f004c0051004c00460044004f000300570055004c0044004f0056000300520051004f004c0051004800030044005700030031002600260031>-10.1 <0003>]TJ ET EMC /Artifact <>BDC BT /TT1 1 Tf 0 Tw 12 0 0 12 565.3123 421.4237 Tm (Member Institutions, )Tj ET EMC /Artifact <>BDC BT 0 0.397 0.645 scn /GS1 gs 12 0 0 12 674.1672 421.4237 Tm (click here:)Tj ET EMC /Artifact <>BDC BT 0 Tc 12 0 0 12 726.9848 421.4237 Tm ( )Tj ET EMC /Artifact <>BDC BT -0.01 Tc 0.01 Tw 12 0 0 12 565.3123 408.4237 Tm (nccn.org/clinical_trials/member_)Tj ET EMC /Artifact <>BDC BT 12 0 0 12 565.3123 395.4237 Tm (institutions.aspx)Tj ET EMC /Artifact <>BDC BT 0 0 0 scn /GS0 gs 0 Tc 0 Tw 12 0 0 12 648.6492 395.4237 Tm (.)Tj ET EMC /Artifact <>BDC BT 0.93 0.112 0.142 scn /GS1 gs /TT0 1 Tf -0.01 Tc 12 0 0 12 565.3123 376.4237 Tm [(NCCN Categories of Evidence and)-9.8 ( )]TJ ET EMC /Artifact <>BDC BT 0.01 Tw 12 0 0 12 565.3123 363.4237 Tm (Consensus:)Tj ET EMC /Artifact <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf -0.055 Tw 12 0 0 12 632.79 363.4237 Tm [( All )-54.8 (recommendations)-10 ( )]TJ ET EMC /Artifact <>BDC BT 0 Tw 12 0 0 12 565.3123 350.4237 Tm [(are category 2A)55.2 ( unless otherwise)-10.1 ( )]TJ ET EMC /Artifact <>BDC BT 0.01 Tw 12 0 0 12 565.3123 337.4237 Tm (indicated.)Tj ET EMC /Artifact <>BDC BT 12 0 0 12 565.3123 318.4237 Tm (See )Tj ET EMC /Artifact <>BDC BT 0 0.397 0.645 scn /GS1 gs 0 Tw 12 0 0 12 589.5178 318.4237 Tm [(NCCN Categories of Evidence)-10.1 ( )]TJ ET EMC /Artifact <>BDC BT 0 Tc 12 0 0 12 751.5621 318.4237 Tm ( )Tj ET EMC /Artifact <>BDC BT -0.01 Tc 12 0 0 12 565.3123 305.4237 Tm (and Consensus)Tj ET EMC /Artifact <>BDC BT 0 0 0 scn /GS0 gs 0 Tc 12 0 0 12 647.1429 305.4237 Tm (.)Tj ET EMC /Artifact <>BDC BT 0.93 0.112 0.142 scn /GS1 gs /TT0 1 Tf -0.01 Tc 12 0 0 12 565.3123 286.4237 Tm (NCCN Categories of Preference:)Tj ET EMC /Artifact <>BDC BT 0 Tc 12 0 0 12 745.8811 286.4237 Tm ( )Tj ET EMC /Artifact <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf -0.01 Tc 12 0 0 12 565.3123 273.4237 Tm [(All recommendations are considered)-10.2 ( )]TJ ET EMC /Artifact <>BDC BT 0.01 Tw 12 0 0 12 565.3123 260.4237 Tm (appropriate.)Tj ET EMC /Artifact <>BDC BT 12 0 0 12 565.3123 241.4237 Tm (See )Tj ET EMC /Artifact <>BDC BT 0 0.397 0.645 scn /GS1 gs -0.011 Tw 12 0 0 12 589.3878 241.4237 Tm (NCCN Categories of Preference)Tj ET EMC /Artifact <>BDC BT 0 0 0 scn /GS0 gs 0 Tc 0 Tw 12 0 0 12 756.922 241.4237 Tm (.)Tj ET EMC 0 0 0 SCN 1 w 4 M 557.612 233.724 210.344 288.136 re S endstream endobj 192 0 obj 11937 endobj %% Contents for page 3 %% Original object ID: 7 0 193 0 obj << /Length 194 0 R >> stream Q q BT /Xi1 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 194 0 obj 244 endobj %% Original object ID: 292 0 195 0 obj [ 2028 0 R 2029 0 R 2030 0 R 2031 0 R 2032 0 R 2033 0 R 2034 0 R 2035 0 R 2036 0 R 2037 0 R 2038 0 R 2039 0 R 2040 0 R 2041 0 R 2042 0 R 2043 0 R 2044 0 R 2045 0 R 2046 0 R 2047 0 R 2048 0 R 2049 0 R 2050 0 R 2051 0 R ] endobj %% Contents for page 4 %% Original object ID: 8 0 196 0 obj << /Length 197 0 R >> stream q endstream endobj 197 0 obj 2 endobj %% Contents for page 4 %% Original object ID: 293 0 198 0 obj << /Length 199 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma)Tj ET EMC /Artifact <>BDC BT /TT1 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm0 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 714.1972 23.544 Tm [(UPDA)73.9 (TES)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 285.7517 Tm [(Updates in V)55.5 (ersion 1.2020 of the NCCN Guidelines for Thyroid Carcinoma from V)56.4 (ersion 2.2019 include:)]TJ ET EMC 0 0 0 SCN q 1 0 0 1 23.544 268.0862 cm 0 0 m 40.965 0 l S Q 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 53.0635 184.0862 cm 0 0 m 336.794 0 l S Q q 1 0 0 1 30.744 172.0862 cm 0 0 m 48.877 0 l S Q 0 0 0 SCN /GS0 gs q 1 0 0 1 23.544 124.0862 cm 0 0 m 100.241 0 l S Q 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 23.544 112.0862 cm 0 0 m 39.725 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 23.544 269.2517 Tm (General)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 257.2517 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 257.2517 Tm <002500480057004b004800560047004400030046004f004400560056004c00bf004600440057004c005200510003005a0044005600030044004700470048004700030057004b005500520058004a004b00520058005700030057004b00480003002a0058004c00470048004f004c0051004800560011>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 23.544 245.2517 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 245.2517 Tm <000500360058005500590048004c004f004f00440051004600480012002400460057004c00590048000300560058005500590048004c004f004f004400510046004800050003004b004400560003004500480048005100030046004f00440055004c00bf0048004700030057004b005500520058004a004b0052005800570003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 30.744 233.2517 Tm (the Guidelines as "Nodule surveillance," "Monitoring of residual )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 221.2517 Tm [(disease," " )36.9 (Active surveillance" or "Disease monitoring.")]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.544 209.2517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 209.2517 Tm ("rhTSH" was replaced with "thyrotropin alfa" throughout the )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 197.2517 Tm (Guidelines.)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 185.2517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 185.2517 Tm (The )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 53.0635 185.2517 Tm (Principles of Radiation Therapy and Radioactive Iodine Therapy )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 173.2517 Tm (\(THYR)Tj /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 79.6209 173.2517 Tm [( is new)37.6 (.)]TJ ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 161.2517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 161.2517 Tm (RAI recommendations and dosing have been moved to the new )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 149.2517 Tm (Principles page from the algorithm and footnotes.)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 125.2517 Tm (Thyroid Carcinoma)Tj ET EMC /Span <>BDC BT 11 0 0 11 123.7847 125.2517 Tm ( )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 23.544 113.2517 Tm (THYR-1)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 23.544 101.2517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 101.2517 Tm [(W)18.2 (orkup for Thyroid nodule\(s\) with normal or elevated TSH updated: )]TJ ET EMC /Span <>BDC BT 11 0 0 11 30.744 89.2517 Tm ("...sonographic features a)Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 166.16 89.2517 Tm [(s described by the )37.5 (A)74.1 (T)74.4 (A)36.9 ( and/or TI-RADS or )]TJ ET EMC /Span <>BDC BT 11 0 0 11 30.744 77.2517 Tm (Nodule surveillance)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 134.6693 77.2517 Tm [(." )37.3 (Also for THYR)]TJ /Span<>> BDC (-)Tj EMC (4.)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 65.2517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 65.2517 Tm [(Sonographic features table was replaced with a reference to the )38 (A)74 (T)74.4 (A)37 ( )]TJ ET EMC /Span <>BDC BT 11 0 0 11 30.744 53.2517 Tm (and TI)Tj /Span<>> BDC (-)Tj EMC (RADS.)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 41.2517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 41.2517 Tm (Footnote b is new: "TI-RADS \()Tj ET EMC /Span <>BDC BT 11 0 0 11 187.2066 41.2517 Tm [(https://www)38.1 (.jacr)55 (.org/article/)]TJ ET EMC /Span <>BDC BT 11 0 0 11 30.744 29.2517 Tm (S1546-1440\(17\)30186-2/pdf)Tj ET EMC /Span <>BDC BT 11 0 0 11 170.7738 29.2517 Tm [(\) or )37.4 (A)74.1 (T)74.4 (A)36.9 ( \()]TJ ET EMC /Span <>BDC BT 11 0 0 11 218.4261 29.2517 Tm [(https://www)38.1 (.ncbi.nlm.nih.gov/)]TJ ET EMC /GS1 gs q 1 0 0 1 402 244.0862 cm 0 0 m 39.725 0 l S Q q 1 0 0 1 402 100.0862 cm 0 0 m 39.725 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 409.2 269.2517 Tm [(pmc/articles/PMC4739132/pdf/thy)73.4 (.2015.0020.pdf)]TJ ET EMC /Span <>BDC BT 11 0 0 11 657.8333 269.2517 Tm [(\)" )37.2 (Also for THYR)]TJ /Span<>> BDC (-)Tj EMC (2, )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 257.2517 Tm (THYR)Tj /Span<>> BDC (-)Tj EMC (3, and THYR)Tj /Span<>> BDC (-)Tj EMC (4.)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 402 245.2517 Tm (THYR-2)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 402 233.2517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 233.2517 Tm [(Benign \(Bethesda II\) T)56 (reatment updated: "Nodule surveillance )]TJ ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 735.6255 233.2517 Tm (as )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 221.2517 Tm [(recommended by the )37.2 (A)74 (T)74.4 (A)36.9 ( or TI-RADS)]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 604.7723 221.2517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 607.8284 221.2517 Tm [(If nodule growth,t repeat FNA)38.6 ( )]TJ ET EMC 0 0 0 SCN q 1 0 0 1 607.8284 224.9184 cm 0 0 m 156.643 0 l S Q /Span <>BDC BT 11 0 0 11 409.2 209.2517 Tm (or consider surgery)Tj ET EMC q 1 0 0 1 409.2 212.9184 cm 0 0 m 102.497 0 l S Q /Span <>BDC BT 11 0 0 11 511.6966 209.2517 Tm (.")Tj ET EMC /Span <>BDC BT 11 0 0 11 402 197.2517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 197.2517 Tm (Footnotes were removed:)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 405.6 185.2517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 185.2517 Tm (Repeat ultrasound after 6\22612 months, if stable for 1\2262 years, then ) Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 173.2517 Tm (subsequent ultrasound can be considered at 3- to 5-year intervals.)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 405.6 161.2517 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 416.6 161.2517 Tm <002a00550052005a0057004b00030047004800bf005100480047000300440056000300210018001300080003004c00510046005500480044005600480003004c005100030051005200470058004f0048000300590052004f00580050004800030052005500030015001300080003>Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 149.2517 Tm <004c00510046005500480044005600480003004c005100030056004c005d00480003005200490003001500b1001600030047004c0050004800510056004c005200510056001100030036004c005d004800030046004b00440051004a0048005600030056004b00520058004f00470003004500480003002100150003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.4 137.2517 Tm (mm and should be assessed by direct comparison of images. )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 125.2517 Tm [(Generally)74.1 (, more than two biopsies on a growing benign nodule are )]TJ ET EMC /Span <>BDC BT 11 0 0 11 416.4 113.2517 Tm (not indicated.)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 402 101.2517 Tm (THYR-3)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 402 89.2517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 89.2517 Tm [(Follicular or Hürthle cell neoplasm T)56.9 (reatment)]TJ ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 405.6 77.2517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 77.2517 Tm (2nd bullet: "for follicular neoplasm" was removed.)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 405.6 65.2517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 65.2517 Tm (3rd bullet was updated: "Consider nodule surveillance if low risk )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 53.2517 Tm (or patient preference )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 528.8761 53.2517 Tm [(as recommended by the )37 (A)74.1 (T)74.4 (A)36.9 ( or TI-RADS)]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 739.7399 53.2517 Tm (")Tj ET EMC 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 714.0791 37.6262 cm 0 0 m 54.377 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 714.0791 38.7917 Tm (Continued)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 23.544 514.3517 Tm [(Updates in V)55.5 (ersion 2.2020 of the NCCN Guidelines for Thyroid Carcinoma from V)56.4 (ersion 1.2020 include:)]TJ ET EMC 0 0 0 SCN q 1 0 0 1 23.544 496.6862 cm 0 0 m 105.768 0 l S Q 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 23.544 484.6862 cm 0 0 m 37.7 0 l S Q q 1 0 0 1 206.1129 484.6862 cm 0 0 m 38.495 0 l S Q q 1 0 0 1 270.2759 484.6862 cm 0 0 m 39.725 0 l S Q q 1 0 0 1 216.7665 424.6862 cm 0 0 m 37.093 0 l S Q q 1 0 0 1 259.9716 424.6862 cm 0 0 m 38.495 0 l S Q q 1 0 0 1 327.1908 424.6862 cm 0 0 m 39.725 0 l S Q 0 0 0 SCN /GS0 gs q 1 0 0 1 23.544 400.6862 cm 0 0 m 111.257 0 l S Q 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 23.544 388.6862 cm 0 0 m 42.168 0 l S Q q 1 0 0 1 210.5816 388.6862 cm 0 0 m 42.168 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 23.544 497.8517 Tm (Papillary Carcinoma)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 23.544 485.8517 Tm [(P)74.2 (AP)]TJ /Span<>> BDC (-)Tj EMC (10)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 61.2437 485.8517 Tm ( \(All changes also made on )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 206.1129 485.8517 Tm (FOLL)Tj /Span<>> BDC (-)Tj EMC (8)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 244.6075 485.8517 Tm ( and )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 270.2759 485.8517 Tm <48dc5254>Tj /Span<>> BDC 2.722 0 Td (-)Tj EMC (8)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 310.0005 485.8517 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 473.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 473.8517 Tm (2nd column, 2nd bullet: "and tumor mutational burden \(TMB\)" was )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 461.8517 Tm (added.)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 449.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 449.8517 Tm ("Pembrolizumab for patients with tumor mutational burden)Tj /Span<>> BDC (-)Tj EMC (high )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.744 437.8517 Tm <000b0037003000250010002b000c0003000b009500140013000300500058005700440057004c005200510056001200500048004a004400450044005600480003003e0050005800570012003000450040000c000300570058005000520055005600050003005a004400560003004400470047004800470003004400560003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 30.744 425.8517 Tm [(a systemic therapy option. )37.5 (Also for )]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 216.7665 425.8517 Tm [(P)74.2 (AP)]TJ /Span<>> BDC (-)Tj EMC [(1)54.9 (1)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 253.8592 425.8517 Tm (, )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 259.9716 425.8517 Tm (FOLL)Tj /Span<>> BDC (-)Tj EMC (9)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 298.4662 425.8517 Tm (, and )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 327.1908 425.8517 Tm <48dc5254>Tj /Span<>> BDC 2.722 0 Td (-)Tj EMC (9)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 366.9154 425.8517 Tm (.)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 401.8517 Tm (Medullary Carcinoma)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 23.544 389.8517 Tm (MEDU)Tj /Span<>> BDC (-)Tj EMC (6)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 65.7125 389.8517 Tm ( \(All changes also made on )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 210.5816 389.8517 Tm (MEDU)Tj /Span<>> BDC (-)Tj EMC (7)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 252.7501 389.8517 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 377.8517 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 377.8517 Tm <0005003300480050004500550052004f004c005d005800500044004500030049005200550003005300440057004c00480051005700560003005a004c0057004b00030037003000250010002b0003000b0095001400130003005000580057001200300045000c000300570058005000520055005600050003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 30.744 365.8517 Tm (was added as a systemic therapy option \(Useful in Certain )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 353.8517 Tm (Circumstances\).)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 341.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 341.8517 Tm [("Genomic testing including tumor mutational burden \(TMB\) or)58.4 (..." )]TJ ET EMC /Span <>BDC BT 11 0 0 11 30.744 329.8517 Tm (was added to footnote s. )Tj ET EMC 0 0 0 SCN q 1 0 0 1 402 496.6862 cm 0 0 m 115.538 0 l S Q 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 402 484.6862 cm 0 0 m 40.949 0 l S Q q 1 0 0 1 402 448.6862 cm 0 0 m 40.949 0 l S Q q 1 0 0 1 402 400.6862 cm 0 0 m 81.479 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 402 497.8517 Tm (Anaplastic Carcinoma)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 402 485.8517 Tm (ANAP)Tj /Span<>> BDC (-)Tj EMC (1)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 402 473.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 473.8517 Tm [(Footnote b was updated: "...BRAF)112.5 (, NTRK, )37.5 (ALK, )]TJ ET EMC /Span <>BDC BT 11 0 0 11 656.9229 473.8517 Tm (and)Tj ET EMC 0 0 0 SCN q 1 0 0 1 656.9229 477.5183 cm 0 0 m 19.556 0 l S Q /Span <>BDC BT 11 0 0 11 676.479 473.8517 Tm [( RET)111 (, )]TJ ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 706.4282 473.8517 Tm (and tumor )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 461.8517 Tm (mutational burden)Tj ET EMC /Span <>BDC BT /TT0 1 Tf -0.037 Tw 11 0 0 11 505.1439 461.8517 Tm [(." Also )-36.8 (for ANAP)]TJ /Span<>> BDC (-)Tj EMC (2.)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 0 Tw 11 0 0 11 402 449.8517 Tm (ANAP)Tj /Span<>> BDC (-)Tj EMC (2)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 402 437.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 437.8517 Tm (Reference for pembrolizumab for TMB)Tj /Span<>> BDC (-)Tj EMC (H was added to footnote g: )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 425.8517 Tm [("Marabelle )36.9 (A, et al. Presented at the )37.5 (Annual Meeting of ESMO in )]TJ ET EMC /Span <>BDC BT 11 0 0 11 409.2 413.8517 Tm (Barcelona, Spain; September 30, 2019")Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 402 401.8517 Tm (ANAP)Tj /Span<>> BDC (-)Tj EMC [(A)36.4 ( \(2 of 3\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 402 389.8517 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 408.9072 389.8517 Tm <0005003300480050004500550052004f004c005d005800500044004500030049005200550003005300440057004c00480051005700560003005a004c0057004b00030037003000250010002b0003000b0095001400130003005000580057001200300045000c000300570058005000520055005600050003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 409.2 377.8517 Tm (was added as a systemic therapy option \(Useful in Certain )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 365.8517 Tm (Circumstances\))Tj ET EMC /Artifact <>BDC 1 w 4 M q 1 0 0 1 23.544 312.6136 cm 0 0 m 744.912 0 l S Q EMC endstream endobj 199 0 obj 20577 endobj %% Contents for page 4 %% Original object ID: 9 0 200 0 obj << /Length 201 0 R >> stream Q q BT /Xi2 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 201 0 obj 244 endobj %% Original object ID: 294 0 202 0 obj << /BaseFont /EQZPCQ+Webdings /DescendantFonts 2052 0 R /Encoding /Identity-H /Subtype /Type0 /ToUnicode 2053 0 R /Type /Font >> endobj %% Original object ID: 295 0 203 0 obj << /BaseFont /YHCFWC+Arial-BoldItalicMT /Encoding /WinAnsiEncoding /FirstChar 32 /FontDescriptor 2055 0 R /LastChar 150 /Subtype /TrueType /ToUnicode 2056 0 R /Type /Font /Widths [ 278 0 0 0 0 889 0 0 0 0 0 0 278 333 278 278 556 556 556 556 0 556 0 0 0 0 0 0 584 0 584 0 0 722 722 722 722 667 611 0 722 278 0 722 611 0 722 0 667 0 722 667 611 0 0 0 0 0 0 0 0 0 0 0 0 556 611 556 611 556 333 611 611 278 0 556 278 889 611 611 611 0 389 556 333 611 556 778 0 556 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 556 ] >> endobj %% Original object ID: 297 0 204 0 obj [ 2058 0 R 2059 0 R 2060 0 R 2061 0 R 2062 0 R 2063 0 R 2064 0 R 2065 0 R 2066 0 R 2067 0 R 2068 0 R 2069 0 R 2070 0 R 2071 0 R 2072 0 R 2073 0 R 2074 0 R 2075 0 R 2076 0 R 2077 0 R ] endobj %% Contents for page 5 %% Original object ID: 10 0 205 0 obj << /Length 206 0 R >> stream q endstream endobj 206 0 obj 2 endobj %% Contents for page 5 %% Original object ID: 298 0 207 0 obj << /Length 208 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma)Tj ET EMC /Artifact <>BDC BT /TT1 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm0 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 11 0 0 11 23.544 514.3517 Tm [(Updates in V)55.5 (ersion 1.2020 of the NCCN Guidelines for Thyroid Carcinoma from V)56.4 (ersion 2.2019 include:)]TJ ET EMC /GS1 gs q 1 0 0 1 23.544 496.6862 cm 0 0 m 39.725 0 l S Q 0 0 0 SCN /GS0 gs q 1 0 0 1 23.544 364.6862 cm 0 0 m 105.768 0 l S Q 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 23.544 352.6862 cm 0 0 m 31.582 0 l S Q 0 0 0 SCN /GS0 gs q 1 0 0 1 225.7671 256.6862 cm 0 0 m 18.955 0 l S Q q 1 0 0 1 222.104 220.6862 cm 0 0 m 11 0 l S Q q 1 0 0 1 306.2422 220.6862 cm 0 0 m 12.23 0 l S Q 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 23.544 111.4861 cm 0 0 m 31.582 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 23.544 497.8517 Tm (THYR-3)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 63.2686 497.8517 Tm ( \(continued\))Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 485.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 485.8517 Tm [(AUS/FLUS without radiographic suspicion of malignancy T)58.2 (reatment )]TJ ET EMC /Span <>BDC BT 11 0 0 11 30.744 473.8517 Tm (was updated)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 461.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 461.8517 Tm (2nd bullet: "\(if Bethesda III on 2 or more occasions\)" was added.)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 449.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 449.8517 Tm (Last bullet was updated: ")Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 174.7631 449.8517 Tm (Consider )Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 225.4931 449.8517 Tm (nodule surveillance )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 331.2499 449.8517 Tm (as )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 437.8517 Tm [(recommended by the )37.2 (A)74 (T)74.4 (A)36.9 ( or TI-RADS)]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 233.5162 437.8517 Tm (")Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 425.8517 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 30.4512 425.8517 Tm <002900520052005700510052005700480003004a0003005a0044005600030058005300470044005700480047001d00030005002800560057004c0050004400570048004700030055004c0056004e000300520049000300500044004f004c004a0051004400510046005c0003004c005600030019000800b10014001b00080003>Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 30.744 413.8517 Tm [(without NIFTP)38.4 ( and 10%\22630% with NIFTP)129.5 (.)]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 241.6024 413.8517 Tm [(" )37.2 (Also for THYR)]TJ /Span<>> BDC (-)Tj EMC (4.)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 401.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 401.8517 Tm [(A)36.9 ( footnote was deleted: "Molecular diagnostics may not perform )]TJ ET EMC /Span <>BDC BT 11 0 0 11 30.744 389.8517 Tm [(well for Hürthle cell neoplasms." )38.2 (Also for THYR)]TJ /Span<>> BDC (-)Tj EMC (4.)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 365.8517 Tm (Papillary Carcinoma)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 23.544 353.8517 Tm [(P)74.2 (AP-1)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 23.544 341.8517 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 30.4512 341.8517 Tm [<00050095001400030046005000030044005100470003001f0014000300460050000500030045004c004900580055004600440057004c005200510003004c0056000300510048005a>38.2 <0011>]TJ ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 329.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 38.144 329.8517 Tm [<001f00140003004600500003005300440057004b005a0044005c0003004c0056000300510048005a>37.5 <0011>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 23.544 317.8517 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 30.4512 317.8517 Tm <0095001400030046005000030027004c0044004a0051005200560057004c0046000300330055005200460048004700580055004800560003005a00480055004800030058005300470044005700480047001d>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 305.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 305.8517 Tm (2nd bullet: "CT/MRI with contrast for )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 232.1855 305.8517 Tm (locally advanced disease or )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 293.8517 Tm (vocal cord paresis)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 134.5485 293.8517 Tm ( )Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 137.6046 293.8517 Tm [<00bf005b00480047000f000300450058004f004e005c>74.7 <000f0003005200550003005600580045005600570048005500510044004f0003004f00480056004c005200510056>]TJ ET EMC 0 0 0 SCN q 1 0 0 1 137.6046 297.5183 cm 0 0 m 176.457 0 l S Q /Span <>BDC BT /TT0 1 Tf 11 0 0 11 314.0612 293.8517 Tm (.)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 281.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 281.8517 Tm (Last bullet: "Strongly" was added.)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 269.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 269.8517 Tm (Preoperative or Intraoperative Decision)Tj /Span<>> BDC (-)Tj EMC (Making Criteria)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 257.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 257.8517 Tm (Indications for total thyroidectomy \()Tj ET EMC /Span <>BDC BT 11 0 0 11 225.767 257.8517 Tm (any)Tj ET EMC /Span <>BDC BT 11 0 0 11 244.7216 257.8517 Tm ( present\) 4th bullet was )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 245.8517 Tm (updated: "Cervical lymph node metastases )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 266.2853 245.8517 Tm (or gross central neck )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 233.8517 Tm (lymph node metastases)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 162.6554 233.8517 Tm (")Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 221.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 221.8517 Tm (Indications for total thyroidectomy )Tj ET EMC /Span <>BDC BT 11 0 0 11 222.1039 221.8517 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 233.1039 221.8517 Tm [( lobectomy)74.4 (, if )]TJ ET EMC /Span <>BDC BT 11 0 0 11 306.2421 221.8517 Tm (all)Tj ET EMC /Span <>BDC BT 11 0 0 11 318.4721 221.8517 Tm ( criteria )Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 37.944 209.8517 Tm [<00530055004800560048005100570003004f004400560057000300450058004f004f004800570003005a0044005600030046004b00440051004a0048004700030049005500520050000300050037>75.2 <00580050005200550003009400170003004600500011001100110005000300570052000300050037>75.2 <00580050005200550003>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 37.944 197.8517 Tm (1\2264 cm...")Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 185.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 185.8517 Tm (Footnote b was updated: "Use of iodinated contrast is required for )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 173.8517 Tm [(optimal cervical imaging using CT)112.2 (; )]TJ ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 221.9254 173.8517 Tm (potential delay in RAI treatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 161.8517 Tm (will not cause harm.)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 143.0831 161.8517 Tm ( ,)Tj ET EMC /Span <>BDC BT 11 0 0 11 149.1954 161.8517 Tm ( although iodinated contrast will delay )Tj ET EMC q 1 0 0 1 149.1954 165.5184 cm 0 0 m 202.909 0 l S Q /Span <>BDC BT 11 0 0 11 37.944 149.8517 Tm (treatment with RAI.)Tj ET EMC q 1 0 0 1 37.944 153.5184 cm 0 0 m 100.23 0 l S Q /Span <>BDC BT 11 0 0 11 138.174 149.8517 Tm [(" )37.2 (Also for FOLL)]TJ /Span<>> BDC (-)Tj EMC (1 and HURT)Tj /Span<>> BDC 13.326 0 Td (-)Tj EMC (1.)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 137.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 137.8517 Tm (Footnote e is new: "Routine prophylactic central neck dissection is )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 125.8517 Tm (not indicated in most papillary thyroid cancers.")Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 23.544 112.6517 Tm [(P)74.2 (AP)]TJ /Span<>> BDC (-)Tj EMC (2)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 23.544 99.4517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 99.4517 Tm [(Lobectomy + isthmusectomy)74.1 (, )37.5 (Any of the following: )]TJ ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 87.4517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 87.4517 Tm [("Gross" added to second bullet. )38.6 (Also for P)74.5 (AP)]TJ /Span<>> BDC (-)Tj EMC (3.)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 75.4517 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 38.144 75.4517 Tm <00180057004b000300450058004f004f004800570003004c0056000300510048005a001d000300260052005100bf00550050004800470003004600520051005700550044004f00440057004800550044004f00030047004c005600480044005600480005>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 63.4517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 63.4517 Tm (6th bullet updated: ")Tj ET EMC /Span <>BDC BT 11 0 0 11 144.7978 63.4517 Tm (Macroscopic)Tj ET EMC q 1 0 0 1 144.7978 67.1184 cm 0 0 m 67.246 0 l S Q /Span <>BDC BT 11 0 0 11 212.0439 63.4517 Tm ( )Tj ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 215.1 63.4517 Tm <00260052005100bf0055005000480047>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 270.1 63.4517 Tm ( nodal metastasis")Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 51.4517 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 38.144 51.4517 Tm <002f004400560057000300450058004f004f004800570003004c0056000300510048005a001d000300050033005200520055004f005c00030047004c108700480055004800510057004c00440057004800470005>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 23.544 38.2517 Tm <9520>Tj ET EMC 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 402 495.4861 cm 0 0 m 31.582 0 l S Q q 1 0 0 1 402 404.2862 cm 0 0 m 31.582 0 l S Q q 1 0 0 1 402 367.0862 cm 0 0 m 31.582 0 l S Q q 1 0 0 1 620.6519 355.0862 cm 0 0 m 38.495 0 l S Q q 1 0 0 1 684.8149 355.0862 cm 0 0 m 39.725 0 l S Q q 1 0 0 1 402 343.0862 cm 0 0 m 31.582 0 l S Q q 1 0 0 1 656.3936 319.0862 cm 0 0 m 37.835 0 l S Q q 1 0 0 1 719.3467 319.0862 cm 0 0 m 39.065 0 l S Q q 1 0 0 1 402 235.0862 cm 0 0 m 31.582 0 l S Q q 1 0 0 1 620.6519 223.0862 cm 0 0 m 38.495 0 l S Q q 1 0 0 1 681.7588 223.0862 cm 0 0 m 42.781 0 l S Q q 1 0 0 1 402 211.0862 cm 0 0 m 31.582 0 l S Q q 1 0 0 1 578.4512 211.0862 cm 0 0 m 38.495 0 l S Q q 1 0 0 1 642.6143 211.0862 cm 0 0 m 39.725 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 402 496.6517 Tm [(P)74.2 (AP)]TJ /Span<>> BDC (-)Tj EMC (2)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 433.582 496.6517 Tm ( \(continued\))Tj ET EMC /Span <>BDC BT 11 0 0 11 402 483.4517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 483.4517 Tm [(Lobectomy + isthmusectomy)74.1 (, )37.5 (All of the following:)]TJ ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 405.6 470.2517 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 416.6 470.2517 Tm <0029004c005500560057000300450058004f004f0048005700030046004f00440055004c00bf00480047001d00030005>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 529.9999 470.2517 Tm (Negative )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 578.9091 470.2517 Tm (resection)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 627.8182 470.2517 Tm ( margins")Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 405.6 458.2517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 458.2517 Tm [(3rd and 4th bullets were added to be consistent with P)76.8 (AP)]TJ /Span<>> BDC (-)Tj EMC (3.)Tj ET EMC /Span <>BDC BT 11 0 0 11 402 445.0517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 445.0517 Tm (Footnote g was updated: "Completion thyroidectomy is not required )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 431.8517 Tm (for )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 426.9192 431.8517 Tm (incidental)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 478.2615 431.8517 Tm ( small volume pathologic N1a metastases \()Tj ET EMC /Span <>BDC BT 11 0 0 11 702.6174 431.8517 Tm (fewer than )Tj ET EMC 0 0 0 SCN q 1 0 0 1 702.6174 435.5183 cm 0 0 m 58.067 0 l S Q /Span <>BDC BT 11 0 0 11 409.2 418.6517 Tm (3)Tj /Span<>> BDC (-)Tj EMC ET EMC q 1 0 0 1 409.2 422.3183 cm 0 0 m 9.781 0 l S Q /Span <>BDC BT 11 0 0 11 418.9807 418.6517 Tm ( )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 422.0369 418.6517 Tm (<5)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 434.5784 418.6517 Tm ( involved nodes...")Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 401.9999 405.4517 Tm [(P)74.2 (AP)]TJ /Span<>> BDC (-)Tj EMC (3)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 401.9999 393.4517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 393.4517 Tm (All of the following: "or NIFTP" was added to be consistent with )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 381.4517 Tm [(P)74.2 (AP)]TJ /Span<>> BDC (-)Tj EMC (2.)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 401.9999 368.2517 Tm [(P)74.2 (AP-4)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 401.9999 356.2517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 356.2517 Tm [(This page was extensively revised. )37.3 (Also )]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 620.6518 356.2517 Tm (FOLL)Tj /Span<>> BDC (-)Tj EMC (2)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 659.1464 356.2517 Tm ( and )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 684.8149 356.2517 Tm (H)Tj ET EMC /Span <>BDC BT 11 0 0 11 692.7587 356.2517 Tm Tj ET EMC /Span <>BDC BT 11 0 0 11 700.7026 356.2517 Tm (RT)Tj /Span<>> BDC 1.278 0 Td (-)Tj EMC (2)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 724.5395 356.2517 Tm (.)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 401.9999 344.2517 Tm [(P)74.2 (AP)]TJ /Span<>> BDC (-)Tj EMC (5)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 401.9999 332.2517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 332.2517 Tm ("Positive postoperative ultrasound, if done" was removed from RAI )Tj ET EMC /Span <>BDC BT -0.01 Tc 11 0 0 11 409.2 320.2517 Tm (selectively recommended \(if any present\). \(Also )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 0.01 Tw 11 0 0 11 656.3936 320.2517 Tm (FOLL)Tj /Span<>> BDC (-)Tj EMC (3)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 0 Tw 11 0 0 11 694.2283 320.2517 Tm ( and )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 0 Tc 11 0 0 11 719.3467 320.2517 Tm (H)Tj ET EMC /Span <>BDC BT 11 0 0 11 727.1805 320.2517 Tm Tj ET EMC /Span <>BDC BT -0.01 Tc 0.01 Tw 11 0 0 11 735.0144 320.2517 Tm (RT)Tj /Span<>> BDC 1.258 0 Td (-)Tj EMC (3)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 0 Tc 0 Tw 11 0 0 11 758.4114 320.2517 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 402 308.2517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 308.2517 Tm [(Considerations for Initial Postoperative Use of RAI )38.4 (After T)74 (otal )]TJ ET EMC /Span <>BDC BT 11 0 0 11 409.2 296.2517 Tm (Thyroidectomy was updated: "RAI ablation is not required in )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 284.2517 Tm (patients with classic PTC who have T1b/T2 \(1\2264 cm\) )Tj ET EMC /Span <>BDC BT 11 0 0 11 683.6683 284.2517 Tm (cN0 c)Tj ET EMC q 1 0 0 1 683.6683 287.9183 cm 0 0 m 29.353 0 l S Q /Span <>BDC BT /TT2 1 Tf 11 0 0 11 713.0213 284.2517 Tm (N0a )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 272.2517 Tm (and/or )Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 445.8685 272.2517 Tm (c)Tj ET EMC q 1 0 0 1 445.8685 275.9183 cm 0 0 m 6.118 0 l S Q /Span <>BDC BT /TT2 1 Tf 11 0 0 11 451.9861 272.2517 Tm (N0b)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 472.7669 272.2517 Tm ( disease or small-volume N1a disease \(fewer than )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 260.2517 Tm <3396>Tj ET EMC q 1 0 0 1 409.2 263.9183 cm 0 0 m 12.235 0 l S Q /Span <>BDC BT 11 0 0 11 421.4354 260.2517 Tm (5 metastatic lymph nodes with )Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 584.0291 260.2517 Tm <001f0018>Tj ET EMC q 1 0 0 1 584.0291 263.9183 cm 0 0 m 12.542 0 l S Q /Span <>BDC BT /TT0 1 Tf 11 0 0 11 596.5706 260.2517 Tm ( )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 599.6268 260.2517 Tm (<2)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 612.1683 260.2517 Tm ( mm of focus of cancer in )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 248.2517 Tm (node\)...")Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 402 236.2517 Tm [(P)74.2 (AP-6)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 402 224.2517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 224.2517 Tm [(This page was extensively revised. )37.3 (Also )]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 620.6519 224.2517 Tm (FOLL)Tj /Span<>> BDC (-)Tj EMC (4)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 659.1465 224.2517 Tm ( and)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 681.7588 224.2517 Tm ( H)Tj ET EMC /Span <>BDC BT 11 0 0 11 692.7588 224.2517 Tm Tj ET EMC /Span <>BDC BT 11 0 0 11 700.7026 224.2517 Tm (RT)Tj /Span<>> BDC 1.278 0 Td (-)Tj EMC (4)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 724.5396 224.2517 Tm (.)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 402 212.2517 Tm [(P)74.2 (AP-7)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 433.582 212.2517 Tm ( \(All changes also made on )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 578.4512 212.2517 Tm (FOLL)Tj /Span<>> BDC (-)Tj EMC (5)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 616.9458 212.2517 Tm ( and )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 642.6143 212.2517 Tm (H)Tj ET EMC /Span <>BDC BT 11 0 0 11 650.5581 212.2517 Tm Tj ET EMC /Span <>BDC BT 11 0 0 11 658.502 212.2517 Tm (RT)Tj /Span<>> BDC 1.278 0 Td (-)Tj EMC (5)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 682.3389 212.2517 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 402 200.2517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 200.2517 Tm (4th column: )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 405.6 188.2517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 188.2517 Tm ("6 weeks following cross)Tj /Span<>> BDC (-)Tj EMC (sectional imaging: Consider 24)Tj /Span<>> BDC (-)Tj EMC (hour )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 176.2517 Tm (urine iodine." was added.)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 405.6 164.2517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 164.2517 Tm (2nd bullet: "\(thyroid hormone withdrawal or rhTSH\)" was removed.)Tj ET EMC /Span <>BDC BT 11 0 0 11 402 152.2517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 152.2517 Tm (5th column)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 405.6 140.2517 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 416.6 140.2517 Tm <000500260052005100bf00550050004800470003005500440047004c0052004c00520047004c00510048001000440059004c00470003005700580050005200550003>Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 602.1014 140.2517 Tm (or)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 613.1014 140.2517 Tm ( )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 616.1576 140.2517 Tm (Thyroid remnant)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 702.9437 140.2517 Tm ( uptake )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 128.2517 Tm (only" was updated.)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 405.6 116.2517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 116.2517 Tm (")Tj ET EMC /Span <>BDC BT 11 0 0 11 421.8153 116.2517 Tm (Cervical)Tj ET EMC q 1 0 0 1 421.8153 119.9184 cm 0 0 m 42.808 0 l S Q /Span <>BDC BT 11 0 0 11 464.6229 116.2517 Tm ( )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 467.6791 116.2517 Tm (No)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 482.3422 116.2517 Tm ( uptake )Tj ET EMC /Span <>BDC BT 11 0 0 11 523.9091 116.2517 Tm (only)Tj ET EMC q 1 0 0 1 523.9091 119.9184 cm 0 0 m 22.612 0 l S Q /Span <>BDC BT 11 0 0 11 546.5214 116.2517 Tm (" was updated.)Tj ET EMC /Span <>BDC BT 0.035 Tc -0.035 Tw 11 0 0 11 714.1972 23.544 Tm [(UPDA)73.9 (TES)]TJ ET EMC 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 714.0791 36.8662 cm 0 0 m 54.377 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 0 Tc 0 Tw 11 0 0 11 714.0791 38.0317 Tm (Continued)Tj ET EMC endstream endobj 208 0 obj 27224 endobj %% Contents for page 5 %% Original object ID: 11 0 209 0 obj << /Length 210 0 R >> stream Q q BT /Xi3 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 210 0 obj 244 endobj %% Original object ID: 299 0 211 0 obj << /BaseFont /CNADAU+Arial-BoldItalicMT /DescendantFonts 2078 0 R /Encoding /Identity-H /Subtype /Type0 /ToUnicode 2079 0 R /Type /Font >> endobj %% Original object ID: 304 0 212 0 obj [ 2081 0 R 2082 0 R 2083 0 R 2084 0 R 2085 0 R 2086 0 R 2087 0 R 2088 0 R 2089 0 R 2090 0 R 2091 0 R 2092 0 R 2093 0 R 2094 0 R 2095 0 R 2096 0 R 2097 0 R 2098 0 R 2099 0 R 2100 0 R 2101 0 R 2102 0 R 2103 0 R 2104 0 R 2105 0 R ] endobj %% Contents for page 6 %% Original object ID: 12 0 213 0 obj << /Length 214 0 R >> stream q endstream endobj 214 0 obj 2 endobj %% Contents for page 6 %% Original object ID: 305 0 215 0 obj << /Length 216 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma)Tj ET EMC /Artifact <>BDC BT /TT1 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm0 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 11 0 0 11 23.544 514.3517 Tm [(Updates in V)55.5 (ersion 1.2020 of the NCCN Guidelines for Thyroid Carcinoma from V)56.4 (ersion 2.2019 include:)]TJ ET EMC /GS1 gs q 1 0 0 1 23.544 496.6862 cm 0 0 m 31.582 0 l S Q q 1 0 0 1 199.9952 496.6862 cm 0 0 m 38.495 0 l S Q q 1 0 0 1 264.1583 496.6862 cm 0 0 m 39.725 0 l S Q q 1 0 0 1 23.544 364.6862 cm 0 0 m 31.582 0 l S Q q 1 0 0 1 199.9952 364.6862 cm 0 0 m 38.495 0 l S Q q 1 0 0 1 264.1583 364.6862 cm 0 0 m 39.725 0 l S Q q 1 0 0 1 23.544 196.6862 cm 0 0 m 37.7 0 l S Q q 1 0 0 1 206.1129 196.6862 cm 0 0 m 38.495 0 l S Q q 1 0 0 1 270.2759 196.6862 cm 0 0 m 39.725 0 l S Q q 1 0 0 1 23.544 64.6862 cm 0 0 m 37.093 0 l S Q q 1 0 0 1 205.5059 64.6862 cm 0 0 m 38.495 0 l S Q q 1 0 0 1 266.6129 64.6862 cm 0 0 m 42.781 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 23.544 497.8517 Tm [(P)74.2 (AP-8)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 55.126 497.8517 Tm ( \(All changes also made on )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 199.9952 497.8517 Tm (FOLL)Tj /Span<>> BDC (-)Tj EMC (6)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 238.4898 497.8517 Tm ( and )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 264.1583 497.8517 Tm (H)Tj ET EMC /Span <>BDC BT 11 0 0 11 272.1021 497.8517 Tm Tj ET EMC /Span <>BDC BT 11 0 0 11 280.046 497.8517 Tm (RT)Tj /Span<>> BDC 1.278 0 Td (-)Tj EMC (6)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 303.8829 497.8517 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 485.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 485.8517 Tm ("Chest x)Tj /Span<>> BDC (-)Tj EMC (ray and PET/CT" was removed from Long)Tj /Span<>> BDC (-)Tj EMC (term disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 473.8517 Tm (monitoring for NED. )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 461.8517 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 461.8517 Tm <0024004500510052005500500044004f000300bf00510047004c0051004a0056000f00030030004400510044004a00480050004800510057000f00030057004b0048000300490052004f004f0052005a004c0051004a000300450058004f004f004800570003005a0044005600030055004800500052005900480047001d0003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 30.744 449.8517 Tm ("In iodine-responsive tumors, if detectable Tg or distant metastases )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 437.8517 Tm (or soft tissue invasion on initial staging, radioiodine imaging every )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.744 425.8517 Tm <0014001500b1001500170003005000520003005800510057004c004f00030051005200030046004f004c0051004c00460044004f004f005c00030056004c004a0051004c00bf00460044005100570003005500480056005300520051005600480003004c005600030056004800480051000300570052000300350024002c0003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 30.744 413.8517 Tm (treatment \(either withdrawal of thyroid hormone or rhTSH\)")Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 401.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 401.8517 Tm (The following footnote was removed: "If there is a high likelihood of )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 389.8517 Tm [(therapy)73.9 (, thyroid hormone withdrawal is suggested; if not, suggest )]TJ ET EMC /Span <>BDC BT 11 0 0 11 30.744 377.8517 Tm (using rhTSH.")Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 23.544 365.8517 Tm [(P)74.2 (AP)]TJ /Span<>> BDC (-)Tj EMC (9)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 55.126 365.8517 Tm ( \(All changes also made on )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 199.9952 365.8517 Tm (FOLL)Tj /Span<>> BDC (-)Tj EMC (7)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 238.4898 365.8517 Tm ( and )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 264.1583 365.8517 Tm (H)Tj ET EMC /Span <>BDC BT 11 0 0 11 272.1021 365.8517 Tm Tj ET EMC /Span <>BDC BT 11 0 0 11 280.046 365.8517 Tm (RT)Tj /Span<>> BDC 1.278 0 Td (-)Tj EMC (7)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 303.8829 365.8517 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 353.8517 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 353.8517 Tm <0005004400510047000300510048004a00440057004c005900480003004c00500044004a004c0051004a00050003005a0044005600030044004700470048004700030057005200030057004b0048000300bf005500560057000300450058004f004f004800570011>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 23.544 341.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 341.8517 Tm (4th bullet was updated: ")Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 160.9527 341.8517 Tm [<00360057004c00500058004f004400570048004700030037004a000300210014001300030051004a00120050002f>19.3 <000300440051004700030055004c0056004c0051004a>]TJ ET EMC 0 0 0 SCN q 1 0 0 1 160.9527 345.5183 cm 0 0 m 185.91 0 l S Q /Span <>BDC BT /TT0 1 Tf 11 0 0 11 346.8624 341.8517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 329.8517 Tm (Progressively rising Tg \(basal or stimulated\)")Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 317.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 317.8517 Tm (Locoregional recurrence)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 305.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 305.8517 Tm ("Consider preoperative iodine total body scan" was added.)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 293.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 293.8517 Tm (SBRT was added to EBRT option)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 281.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 281.8517 Tm [("For select patients with limited burden nodal disease, consider)57.5 (..." )]TJ ET EMC /Span <>BDC BT 11 0 0 11 37.944 269.8517 Tm (was added to the last option.)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 257.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 257.8517 Tm (Metastatic disease)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 245.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 245.8517 Tm ("RAI therapy for iodine)Tj /Span<>> BDC (-)Tj EMC (avid disease" was added.)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 233.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 233.8517 Tm [("See P)74 (AP)]TJ /Span<>> BDC (-)Tj EMC (10 if not amenable to RAI" was added.)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 221.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 38.144 221.8517 Tm <00290052005200570051005200570048000310870003005a0044005600030044004700470048004700030057005200030057004b004c0056000300530044004a0048001d0003000500280057004b004400510052004f000300440045004f00440057004c00520051000f0003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 37.944 209.8517 Tm [(cryoablation, RF)55.7 (A, etc.")]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 23.544 197.8517 Tm [(P)74.2 (AP-10)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 61.2437 197.8517 Tm ( \(All changes also made on )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 206.1129 197.8517 Tm (FOLL)Tj /Span<>> BDC (-)Tj EMC (8)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 244.6075 197.8517 Tm ( and )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 270.2759 197.8517 Tm (H)Tj ET EMC /Span <>BDC BT 11 0 0 11 278.2198 197.8517 Tm Tj ET EMC /Span <>BDC BT 11 0 0 11 286.1636 197.8517 Tm (RT)Tj /Span<>> BDC 1.278 0 Td (-)Tj EMC (8)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 310.0005 197.8517 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 185.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 185.8517 Tm (2nd column)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 173.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 173.8517 Tm (2nd bullet: "\(including )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 157.624 173.8517 Tm (NTRK)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 188.1748 173.8517 Tm ( and )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 213.8432 173.8517 Tm (RET)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 235.8432 173.8517 Tm ( gene fusions\)" was added.)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 161.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 161.8517 Tm (The last bullet is new: "Consider clinical trial")Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 149.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 149.8517 Tm [(Last column \(also for P)75.1 (AP)]TJ /Span<>> BDC (-)Tj EMC [(1)54.9 (1, FOLL)]TJ /Span<>> BDC (-)Tj EMC (9, and HÜRT)Tj /Span<>> BDC 23.151 0 Td (-)Tj EMC (9\))Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 137.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 137.8517 Tm (2nd sub bullet: Larotrectinib and entrectinib were moved to the )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 125.8517 Tm (algorithm from a footnote.)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 113.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 113.8517 Tm (3rd sub bullet is new: "Selpercatinib for patients with RET)Tj /Span<>> BDC 27.478 0 Td (-)Tj EMC (fusion )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 101.8517 Tm (positive tumors.")Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 89.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 89.8517 Tm (The last bullet is new: "Best supportive care \(See )Tj ET EMC /Span <>BDC BT 11 0 0 11 298.8784 89.8517 Tm (NCCN Guidelines )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 77.8517 Tm (for Palliative Care)Tj ET EMC /Span <>BDC BT 11 0 0 11 130.8747 77.8517 Tm (\)".)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 23.544 65.8517 Tm [(P)74.2 (AP)]TJ /Span<>> BDC (-)Tj EMC [(1)54.9 (1)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 60.6368 65.8517 Tm ( \(All changes also made on )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 205.5059 65.8517 Tm (FOLL)Tj /Span<>> BDC (-)Tj EMC (9)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 244.0005 65.8517 Tm ( and)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 266.6129 65.8517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 269.669 65.8517 Tm (H)Tj ET EMC /Span <>BDC BT 11 0 0 11 277.6129 65.8517 Tm Tj ET EMC /Span <>BDC BT 11 0 0 11 285.5567 65.8517 Tm (RT)Tj /Span<>> BDC 1.278 0 Td (-)Tj EMC (9)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 309.3936 65.8517 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 53.8517 Tm <9520>Tj ET EMC /Span <>BDC BT -0.001 Tw 11 0 0 11 30.4512 53.8517 Tm [(Footnote )0.8 (mm is new: "RAI therapy is an option )1 (in some patients with )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 30.744 41.8517 Tm (bone metastases and RAI)Tj /Span<>> BDC (-)Tj EMC (sensitive disease.")Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 29.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 29.8517 Tm (Footnote oo is new: "TKI therapy should be used with caution in )Tj ET EMC q 1 0 0 1 402 472.6862 cm 0 0 m 108.808 0 l S Q 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 402 460.6862 cm 0 0 m 38.495 0 l S Q q 1 0 0 1 609.4022 400.6862 cm 0 0 m 39.725 0 l S Q q 1 0 0 1 402 388.6862 cm 0 0 m 38.495 0 l S Q q 1 0 0 1 498.0433 364.6862 cm 0 0 m 39.725 0 l S Q 0 0 0 SCN /GS0 gs q 1 0 0 1 402 280.6862 cm 0 0 m 121.639 0 l S Q 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 402 268.6862 cm 0 0 m 39.725 0 l S Q q 1 0 0 1 402 172.6862 cm 0 0 m 39.725 0 l S Q 0 0 0 SCN /GS0 gs q 1 0 0 1 402 88.6862 cm 0 0 m 111.257 0 l S Q 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 402 76.6862 cm 0 0 m 42.168 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 409.2 497.8517 Tm (otherwise untreated CNS metastases due to bleeding risk.")Tj ET EMC /Span <>BDC BT 11 0 0 11 402 473.8517 Tm (Follicular Carcinoma)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 402 461.8517 Tm (FOLL)Tj /Span<>> BDC (-)Tj EMC (1)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 402 449.8517 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 408.9072 449.8517 Tm [<002900310024>36.9 <00030035004800560058004f00570056001d000300290052004f004f004c00460058004f004400550003004f00480056004c00520051000300520049000300580051004700480057004800550050004c00510048004700030056004c004a0051004c00bf004600440051004600480003000b0029002f00380036000c0003>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 409.2 437.8517 Tm (was removed.)Tj ET EMC /Span <>BDC BT 11 0 0 11 402 425.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 425.8517 Tm (Diagnostic Procedures, 2nd bullet was updated: "CT/MRI with )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 413.8517 Tm (contrast for )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 473.3738 413.8517 Tm (locally advanced disease or vocal cord paresis)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 718.5535 413.8517 Tm ( )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 721.6097 413.8517 Tm <00bf005b00480047000f0003>Tj ET EMC 0 0 0 SCN q 1 0 0 1 721.6097 417.5183 cm 0 0 m 31.786 0 l S Q /Span <>BDC BT /TT0 1 Tf 11 0 0 11 409.2 401.8517 Tm [(bulky)74.4 (, or substernal lesions)]TJ ET EMC q 1 0 0 1 409.2 405.5183 cm 0 0 m 144.67 0 l S Q /Span <>BDC BT -0.037 Tw 11 0 0 11 553.8704 401.8517 Tm [(." Also )-36.8 (for )]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 0 Tw 11 0 0 11 609.4022 401.8517 Tm <48dc5254>Tj /Span<>> BDC 2.722 0 Td (-)Tj EMC (1)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 649.1268 401.8517 Tm (.)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 402 389.8517 Tm (FOLL)Tj /Span<>> BDC (-)Tj EMC (1)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 440.4946 389.8517 Tm ( \(continued\))Tj ET EMC /Span <>BDC BT 11 0 0 11 402 377.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 377.8517 Tm (Pathways following Lobectomy/isthmusectomy were extensively )Tj ET EMC /Span <>BDC BT -0.037 Tw 11 0 0 11 409.2 365.8517 Tm [(revised. Also )-36.8 (for )]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 0 Tw 11 0 0 11 498.0433 365.8517 Tm <48dc5254>Tj /Span<>> BDC 2.722 0 Td (-)Tj EMC (1)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 537.7679 365.8517 Tm (.)Tj ET EMC /Span <>BDC BT 11 0 0 11 402 353.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 353.8517 Tm (Footnote d was updated: "Minimally invasive )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 646.9917 353.8517 Tm (FTC)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 668.374 353.8517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 671.4302 353.8517 Tm (cancer)Tj ET EMC q 1 0 0 1 671.4302 357.5183 cm 0 0 m 35.471 0 l S Q /Span <>BDC BT 11 0 0 11 706.9009 353.8517 Tm ( is )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 341.8517 Tm (characterized as a)Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 504.5906 341.8517 Tm (n encapsulated tumor )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 621.9437 341.8517 Tm <005a0048004f004f>Tj /Span<>> BDC <0010>Tj EMC <0047004800bf005100480047000300570058005000520055>Tj ET EMC q 1 0 0 1 621.9437 345.5183 cm 0 0 m 97.781 0 l S Q /Span <>BDC BT /TT0 1 Tf 11 0 0 11 719.7244 341.8517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 329.8517 Tm (with microscopic capsular and)Tj ET EMC /Span <>BDC BT 11 0 0 11 569.9676 329.8517 Tm (/or a few foci of )Tj ET EMC q 1 0 0 1 569.9676 333.5183 cm 0 0 m 83.73 0 l S Q /Span <>BDC BT 11 0 0 11 653.6976 329.8517 Tm ( )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 656.7537 329.8517 Tm (without)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 695.8499 329.8517 Tm ( vascular )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 317.8517 Tm (invasion. )Tj ET EMC /Span <>BDC BT 11 0 0 11 459.9354 317.8517 Tm (\(1\2264\) and often requires examination of at least 10 )Tj ET EMC q 1 0 0 1 459.9354 321.5183 cm 0 0 m 264.687 0 l S Q /Span <>BDC BT 11 0 0 11 409.2 305.8517 Tm (histologic sections to demonstrate)Tj ET EMC q 1 0 0 1 409.2 309.5183 cm 0 0 m 182.139 0 l S Q /Span <>BDC BT 11 0 0 11 591.3392 305.8517 Tm (.")Tj ET EMC /Span <>BDC BT 11 0 0 11 402 281.8517 Tm (Hürthle Cell Carcinoma)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 402 269.8517 Tm <48dc5254>Tj /Span<>> BDC 2.722 0 Td (-)Tj EMC (1)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 402 257.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 257.8517 Tm ("Molecular diagnostics may not perform well for Hürthle cell )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 245.8517 Tm (neoplasms." was removed from footnote a.)Tj ET EMC /Span <>BDC BT 11 0 0 11 402 233.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 233.8517 Tm (Footnote d was updated: "Minimally invasive )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 646.9917 233.8517 Tm (HCC)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 670.8232 233.8517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 673.8794 233.8517 Tm (cancer)Tj ET EMC q 1 0 0 1 673.8794 237.5184 cm 0 0 m 35.471 0 l S Q /Span <>BDC BT 11 0 0 11 709.3501 233.8517 Tm ( is )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 221.8517 Tm (characterized as a)Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 504.5906 221.8517 Tm (n encapsulated tumor )Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 621.9437 221.8517 Tm ( )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 624.9998 221.8517 Tm <005a0048004f004f>Tj /Span<>> BDC <0010>Tj EMC <0047004800bf0051004800470003005700580050005200550003>Tj ET EMC q 1 0 0 1 624.9998 225.5184 cm 0 0 m 100.837 0 l S Q /Span <>BDC BT /TT0 1 Tf 11 0 0 11 409.2 209.8517 Tm (with microscopic capsular and)Tj ET EMC /Span <>BDC BT 11 0 0 11 569.9676 209.8517 Tm (/or a few foci of )Tj ET EMC q 1 0 0 1 569.9676 213.5184 cm 0 0 m 83.73 0 l S Q /Span <>BDC BT 11 0 0 11 653.6976 209.8517 Tm ( )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 656.7537 209.8517 Tm (without)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 695.8499 209.8517 Tm ( vascular )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 197.8517 Tm (invasion. )Tj ET EMC /Span <>BDC BT 11 0 0 11 459.9354 197.8517 Tm (\(1\2264\) and often requires examination of at least 10 )Tj ET EMC q 1 0 0 1 459.9354 201.5184 cm 0 0 m 264.687 0 l S Q /Span <>BDC BT 11 0 0 11 409.2 185.8517 Tm (histologic sections to demonstrate)Tj ET EMC q 1 0 0 1 409.2 189.5184 cm 0 0 m 182.139 0 l S Q /Span <>BDC BT 11 0 0 11 591.3392 185.8517 Tm (.")Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 402 173.8517 Tm (H)Tj ET EMC /Span <>BDC BT 11 0 0 11 409.9438 173.8517 Tm Tj /Span<>> BDC 2 0 Td (-)Tj EMC (3)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 402 161.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 161.8517 Tm [(Footnote j is new: "A)38.5 ( majority of HCC are non\226iodine)]TJ /Span<>> BDC (-)Tj EMC (avid, )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 149.8517 Tm (particularly for high)Tj /Span<>> BDC (-)Tj EMC (risk disease that is negative on iodine)Tj /Span<>> BDC (-)Tj EMC (123/)Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 137.8517 Tm (iodine)Tj /Span<>> BDC (-)Tj EMC [(131 imaging. )38.3 (A)37 ( negative post)]TJ /Span<>> BDC (-)Tj EMC (therapy scan, especially done )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 125.8517 Tm [(without SPECT)111.8 (, will likely miss distant structural disease. If Tg is )]TJ ET EMC /Span <>BDC BT 11 0 0 11 409.2 113.8517 Tm (high and/or pathology is high)Tj /Span<>> BDC (-)Tj EMC (risk, FDG)Tj /Span<>> BDC (-)Tj EMC (PET is indicated.")Tj ET EMC /Span <>BDC BT 11 0 0 11 402 89.8517 Tm (Medullary Carcinoma)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 402 77.8517 Tm (MEDU-1)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 402 65.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 65.8517 Tm (Diagnostic Procedures, 9th bullet is new:)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 405.6 53.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 53.8517 Tm (First sub bullet was updated: "Consider contrast-enhanced CT of )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 416.4 41.8517 Tm (neck/)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 444.5284 41.8517 Tm (chest and liver MRI...")Tj ET EMC /Span <>BDC BT 0.035 Tc -0.035 Tw 11 0 0 11 714.1972 23.544 Tm [(UPDA)73.9 (TES)]TJ ET EMC 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 714.0791 37.8662 cm 0 0 m 54.377 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 0 Tc 0 Tw 11 0 0 11 714.0791 39.0317 Tm (Continued)Tj ET EMC endstream endobj 216 0 obj 27551 endobj %% Contents for page 6 %% Original object ID: 13 0 217 0 obj << /Length 218 0 R >> stream Q q BT /Xi4 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 218 0 obj 244 endobj %% Original object ID: 307 0 219 0 obj [ 2106 0 R 2107 0 R 2108 0 R 2109 0 R 2110 0 R 2111 0 R 2112 0 R 2113 0 R 2114 0 R 2115 0 R 2116 0 R 2117 0 R ] endobj %% Contents for page 7 %% Original object ID: 14 0 220 0 obj << /Length 221 0 R >> stream q endstream endobj 221 0 obj 2 endobj %% Contents for page 7 %% Original object ID: 308 0 222 0 obj << /Length 223 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma)Tj ET EMC /Artifact <>BDC BT /TT1 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm0 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 11 0 0 11 23.544 514.3517 Tm [(Updates in V)55.5 (ersion 1.2020 of the NCCN Guidelines for Thyroid Carcinoma from V)56.4 (ersion 2.2019 include:)]TJ ET EMC /GS1 gs q 1 0 0 1 23.544 460.6862 cm 0 0 m 42.168 0 l S Q q 1 0 0 1 23.544 352.6862 cm 0 0 m 42.168 0 l S Q q 1 0 0 1 23.544 316.6862 cm 0 0 m 42.168 0 l S Q q 1 0 0 1 23.544 208.6862 cm 0 0 m 42.168 0 l S Q q 1 0 0 1 193.4693 208.6862 cm 0 0 m 42.168 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 23.544 497.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 497.8517 Tm (Footnote f was updated: ")Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 165.8243 497.8517 Tm (Imaging may be indicated based on high )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 485.8517 Tm (burden of disease,)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 127.9339 485.8517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 130.9901 485.8517 Tm (Liver imaging is seldom needed if)Tj ET EMC 0 0 0 SCN q 1 0 0 1 130.9901 489.5183 cm 0 0 m 176.655 0 l S Q /Span <>BDC BT 11 0 0 11 307.6454 485.8517 Tm ( calcitonin )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 365.1 485.8517 Tm <001f>Tj ET EMC q 1 0 0 1 365.1 489.5183 cm 0 0 m 6.424 0 l S Q /Span <>BDC BT /TT0 1 Tf 11 0 0 11 371.5238 485.8517 Tm ( )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 30.744 473.8517 Tm (>)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 37.1678 473.8517 Tm (400 pg/mL, )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 97.6839 473.8517 Tm [(or elevated CEA)36.7 ( levels.)]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 218.3348 473.8517 Tm (")Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 23.544 461.8517 Tm (MEDU)Tj /Span<>> BDC (-)Tj EMC (2)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 23.544 449.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 449.8517 Tm (Genetic counseling was moved to the 3rd bullet and updated: )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 437.8517 Tm (")Tj ET EMC /Span <>BDC BT 11 0 0 11 35.9593 437.8517 Tm (Consider)Tj ET EMC q 1 0 0 1 35.9593 441.5183 cm 0 0 m 47.674 0 l S Q /Span <>BDC BT 11 0 0 11 83.6332 437.8517 Tm ( )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 86.6893 437.8517 Tm (with)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 108.6839 437.8517 Tm ( genetic counseling")Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 425.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 425.8517 Tm (Footnote g was updated: "...additional surgical intervention \(eg, )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 413.8517 Tm (completion thyroidectomy ± central neck dissection\) )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 308.7894 413.8517 Tm (may not be )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 401.8517 Tm (necessary)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 84.5677 401.8517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 87.6239 401.8517 Tm (is generally unnecessary)Tj ET EMC q 1 0 0 1 87.6239 405.5183 cm 0 0 m 130.851 0 l S Q /Span <>BDC BT 11 0 0 11 218.4745 401.8517 Tm ( unless...")Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 389.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 389.8517 Tm (Footnote h is new: "Prior to germline testing, all patients should )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.744 377.8517 Tm <0045004800030052108700480055004800470003004a0048005100480057004c00460003004600520058005100560048004f004c0051004a00030048004c0057004b0048005500030045005c00030057004b0048004c005500030053004b005c0056004c0046004c00440051000300520055000300440003004a0048005100480057004c00460003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 30.744 365.8517 Tm [(counselor)55.4 (.")]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 23.544 353.8517 Tm (MEDU-3)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 23.544 341.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 341.8517 Tm [("Neck CT with contrast" was added to )37.8 (Additional W)19.2 (orkup for MEN2B )]TJ ET EMC /Span <>BDC BT 11 0 0 11 30.744 329.8517 Tm (and MEN2A/FMTC.)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 23.544 317.8517 Tm (MEDU)Tj /Span<>> BDC (-)Tj EMC (5)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 23.544 305.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 305.8517 Tm (Detectable basal calcitonin or Elevated CEA)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 293.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 293.8517 Tm [("FDG PET/CT or Ga-68 DOT)75.1 (A)74.1 (T)74.4 (A)74 (TE or MRI with contrast of the )]TJ ET EMC /Span <>BDC BT 11 0 0 11 37.944 281.8517 Tm (neck, chest, abdomen with liver protocol" was moved from the 3rd )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 269.8517 Tm (column to "Disease monitoring" column.)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 257.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 257.8517 Tm (Last bullet)Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 46.9796 245.8517 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 41.544 245.8517 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 50.0357 245.8517 Tm ("Consider" was added.)Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 46.9796 233.8517 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 41.544 233.8517 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 50.0357 233.8517 Tm (Imaging recommendations were moved from a footnote into this )Tj ET EMC /Span <>BDC BT 11 0 0 11 50.184 221.8517 Tm (bullet.)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 23.544 209.8517 Tm (MEDU)Tj /Span<>> BDC (-)Tj EMC (6)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 65.7125 209.8517 Tm ( \(changes also made on )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 193.4693 209.8517 Tm (MEDU)Tj /Span<>> BDC (-)Tj EMC (7)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 235.6378 209.8517 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 197.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 197.8517 Tm (Selpercatinib \()Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 106.2481 197.8517 Tm (RET)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 128.2481 197.8517 Tm ( mutation)Tj /Span<>> BDC (-)Tj EMC (positive\) was added as a preferred )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 185.8517 Tm (treatment option.)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 173.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 173.8517 Tm (Footnote s is new: )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 137.7563 173.8517 Tm (RET)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 159.7563 173.8517 Tm ( somatic genotyping in patients who are )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 161.8517 Tm (germline wild)Tj /Span<>> BDC (-)Tj EMC (type or germline unknown.)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 149.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 149.8517 Tm (Footnote q was updated: "...are not an indication for treatment with )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 30.744 137.8517 Tm (systemic therapy)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 120.6239 137.8517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 123.68 137.8517 Tm (vandetanib or cabozantinib)Tj ET EMC q 1 0 0 1 123.68 141.5184 cm 0 0 m 142.404 0 l S Q /Span <>BDC BT 11 0 0 11 266.0839 137.8517 Tm (.")Tj ET EMC 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 402 496.6862 cm 0 0 m 42.168 0 l S Q 0 0 0 SCN /GS0 gs q 1 0 0 1 402 448.6862 cm 0 0 m 115.538 0 l S Q 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 402 436.6862 cm 0 0 m 40.949 0 l S Q q 1 0 0 1 402 340.6862 cm 0 0 m 40.949 0 l S Q q 1 0 0 1 402 280.6862 cm 0 0 m 81.479 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 402 497.8517 Tm (MEDU)Tj /Span<>> BDC (-)Tj EMC (7)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 402 485.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 485.8517 Tm (Footnote w: "vandetanib or cabozantinib" was replaced with )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 473.8517 Tm ("preferred systemic therapy options".)Tj ET EMC /Span <>BDC BT 11 0 0 11 402 449.8517 Tm (Anaplastic Carcinoma)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 402 437.8517 Tm (ANAP)Tj /Span<>> BDC (-)Tj EMC (1)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 402 425.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 425.8517 Tm ("Molecular testing for actionable mutations" was added to )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 413.8517 Tm (Diagnostic Procedures)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 405.6 401.8517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 401.8517 Tm (Footnote b is new: "Molecular testing should include )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 696.2137 401.8517 Tm [(BRAF)110.5 (, NTRK, )]TJ ET EMC /Span <>BDC BT 11 0 0 11 416.4 389.8517 Tm (ALK)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 439.0069 389.8517 Tm (, and )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 467.7315 389.8517 Tm (RET)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 489.7315 389.8517 Tm (.")Tj ET EMC /Span <>BDC BT 11 0 0 11 402 377.8517 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 408.9072 377.8517 Tm [<00280056005700440045004f004c0056004b0003002a00520044004f005600030052004900030037004b0048005500440053005c>75.1 <000f000300bf005500560057000300450058004f004f00480057001d000300050028005b005300480047004c00480051005700050003005a00440056000300440047004700480047>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 402 365.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 365.8517 Tm [("Resectable" and "Unresectable" bifurcation is new)36.8 (. The following )]TJ ET EMC /Span <>BDC BT 11 0 0 11 409.2 353.8517 Tm (pathways were extensively revised.)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 402 341.8517 Tm (ANAP)Tj /Span<>> BDC (-)Tj EMC (2)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 402 329.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 329.8517 Tm [(Aggressive therapy T)54.8 (reatment, 3rd bullet: "if not previously done" )]TJ ET EMC /Span <>BDC BT 11 0 0 11 409.2 317.8517 Tm (was added.)Tj ET EMC /Span <>BDC BT 11 0 0 11 402 305.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 305.8517 Tm ("Consider selpercatinib if )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 545.5425 305.8517 Tm (RET)Tj ET EMC /Span <>BDC BT /TT0 1 Tf /Span<>> BDC 11 0 0 11 567.5425 305.8517 Tm (-)Tj EMC (fusion positive" with reference was )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 293.8517 Tm (added to footnote g.)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 402 281.8517 Tm [(ANAP-A)36.4 ( \(2 of 3\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 402 269.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 269.8517 Tm (Entrectinib was moved from Other Recommended Regimens to )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 257.8517 Tm (Preferred Regimens.)Tj ET EMC /Span <>BDC BT 11 0 0 11 402 245.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 245.8517 Tm (Selpercatinib \()Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 484.7041 245.8517 Tm (RET)Tj ET EMC /Span <>BDC BT /TT0 1 Tf /Span<>> BDC 11 0 0 11 506.7041 245.8517 Tm (-)Tj EMC (fusion positive\) was added as a preferred )Tj ET EMC /Span <>BDC BT 11 0 0 11 409.2 233.8517 Tm (regimen with dosing and reference.)Tj ET EMC /Span <>BDC BT 11 0 0 11 402 221.8517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 221.8517 Tm (Reference number 4 was updated to the published manuscript.)Tj ET EMC /Span <>BDC BT 0.035 Tc -0.035 Tw 11 0 0 11 714.1972 23.544 Tm [(UPDA)73.9 (TES)]TJ ET EMC endstream endobj 223 0 obj 16542 endobj %% Contents for page 7 %% Original object ID: 15 0 224 0 obj << /Length 225 0 R >> stream Q q BT /Xi5 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 225 0 obj 244 endobj %% Original object ID: 309 0 226 0 obj << /BaseFont /MPYLKA+SymbolMT /DescendantFonts 2118 0 R /Encoding /Identity-H /Subtype /Type0 /ToUnicode 2119 0 R /Type /Font >> endobj %% Original object ID: 311 0 227 0 obj [ 2121 0 R 2122 0 R 2123 0 R 2124 0 R 2125 0 R 2126 0 R 2127 0 R 2128 0 R 2129 0 R 2130 0 R 2131 0 R 2132 0 R 2133 0 R 2134 0 R ] endobj %% Contents for page 8 %% Original object ID: 16 0 228 0 obj << /Length 229 0 R >> stream q endstream endobj 229 0 obj 2 endobj %% Contents for page 8 %% Original object ID: 312 0 230 0 obj << /Length 231 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma)Tj ET EMC /Artifact <>BDC BT /TT1 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 727.3779 23.544 Tm [(THYR)17.3 (-)35 (1)]TJ ET EMC /Span <>BDC BT -0.104 Tw 11 0 0 11 23.7373 514.3517 Tm [(CLINICAL)35.6 ( )0.6 (PRESENT)74.3 (A)73.9 (TION)]TJ ET EMC /Span <>BDC BT -0.035 Tw 11 0 0 11 259.0119 514.3517 Tm (WORKUP)Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 165.6395 394.2802 cm 0 0 m 0 -117.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 385.3358 Tm (For thyroid nodule known )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 373.3358 Tm (or suspected on exam or )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 23.544 361.3358 Tm [<004c00510046004c00470048005100570044004f0003>0.8 <004c00500044004a004c0051004a0003>0.8 <00bf00510047004c0051>0.8 <004a001d>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 23.544 349.3358 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 349.3358 Tm (Measure )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 337.3358 Tm (thyroid-stimulating )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 325.3358 Tm (hormone \(TSH\))Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 313.3358 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 313.3358 Tm (Ultrasound of thyroid )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 301.3358 Tm (and neck including )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 289.3358 Tm (lateral neck lymph node )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 277.3358 Tm (compartments)Tj ET EMC q 1 0 0 1 184.84 359.129 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 239.4427 405.0093 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 11 0 0 11 187 396.065 Tm (Thyroid )Tj ET EMC /Span <>BDC BT 11 0 0 11 187 384.065 Tm (nodule\(s\) )Tj ET EMC /Span <>BDC BT 11 0 0 11 187 372.065 Tm (with low )Tj ET EMC /Span <>BDC BT 11 0 0 11 187 360.065 Tm (TSH)Tj ET EMC q 1 0 0 1 184.84 257.0157 cm 0 0 m 0 57.88 l S Q q 1 0 0 1 251.0245 314.896 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT 11 0 0 11 187 305.9517 Tm (Thyroid )Tj ET EMC /Span <>BDC BT 11 0 0 11 187 293.9517 Tm (nodule\(s\) )Tj ET EMC /Span <>BDC BT 11 0 0 11 187 281.9517 Tm (with normal )Tj ET EMC /Span <>BDC BT 11 0 0 11 187 269.9517 Tm (or elevated )Tj ET EMC /Span <>BDC BT 11 0 0 11 187 257.9517 Tm (TSH)Tj ET EMC /Span <>BDC BT 9 0 0 9 209 261.9517 Tm (a)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 182.63 320.1976 cm 0 0 m -16.169 15.142 l -0.184 30.265 l S Q q 1 0 0 1 186.6168 316.4639 cm 0 0 m -3.374 6.656 l -6.863 2.931 l h f Q q 1 0 0 1 186.4135 354.2161 cm 0 0 m -6.848 -2.966 l -3.34 -6.673 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 75.6296 151.3964 cm 0 0 m 244.585 0 l S Q q 1 0 0 1 360.9617 151.3964 cm 0 0 m 75.029 0 l S Q q 1 0 0 1 29.5212 140.3964 cm 0 0 m 269.976 0 l S Q q 1 0 0 1 335.6345 85.3964 cm 0 0 m 36.113 0 l S Q q 1 0 0 1 377.1238 85.3964 cm 0 0 m 36.113 0 l S Q q 1 0 0 1 29.5212 74.3964 cm 0 0 m 36.113 0 l S Q /Span <>BDC BT /GS0 gs /TT1 1 Tf 8 0 0 8 23.7612 166.456 Tm (a)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 163.456 Tm [(Evalua)-0.6 (te and treat for hypothyroidism as clinically indicat)-2.1 (ed.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 155.456 Tm (b)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 152.456 Tm (TI-RADS \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 75.6296 152.456 Tm [(https://www)55.2 (.jacr)55.1 (.org/article/S1546-1440\(17\)301)-1.9 (86-2/pdf)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 320.2146 152.456 Tm [(\) or )55.3 (A)74.3 (T)74.3 (A)55.2 ( \()]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 360.9616 152.456 Tm [(https://www)55.2 (.ncbi.)]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 141.456 Tm [(nlm.nih.gov/pmc/articles/PMC4739132/pdf/thy)72.3 (.2015.0020.pdf)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 299.4968 141.456 Tm (\).)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 133.456 Tm (c)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT -0.003 Tw 10 0 0 10 29.5212 130.456 Tm [(For well-defin)-0.6 (ed, autonomou)-0.9 (s nodules )-0.9 (FNA)55.1 ( is rarely indic)-0.6 (ated and repeat ultrasound )-0.9 (may not be )]TJ ET EMC /Span <>BDC BT 0 Tw 10 0 0 10 29.5212 119.456 Tm [(necessary)73.6 (. For other nodules not meeting criteria for FNA, or nodules that appear to be benign ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 108.456 Tm (by ultrasound or FNA, surveillance should include repeat ultrasound after 6\22612 months; if stable ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm (for 1\2262 years, then subsequent ultrasound can be considered at 3- to 5-year intervals. If growth ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 86.456 Tm [(and/or change in ultrasonographic features, consider FNA)52.2 ( and follow )]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 335.6345 86.456 Tm (THYR)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 366.1862 86.456 Tm (2)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 371.7478 86.456 Tm (, )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 377.1237 86.456 Tm (THYR-3)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 413.237 86.456 Tm (, and )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 75.456 Tm (THYR-4)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 65.6345 75.456 Tm ( for subsequent management.)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 241.12 382.0692 cm 0 0 m 9.464 0 l S Q q 1 0 0 1 256.0459 382.0692 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 256.0459 284.8 cm 0 0 m 171.797 0 l S Q q 1 0 0 1 433.3047 284.8 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 256.6586 341.129 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 324.0892 411.0093 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT /TT0 1 Tf 11 0 0 11 258.8186 402.065 Tm (Radioiodine)Tj ET EMC /Span <>BDC BT 11 0 0 11 258.8186 390.065 Tm (imaging )Tj ET EMC /Span <>BDC BT 11 0 0 11 258.8186 378.065 Tm (iodine)Tj /Span<>> BDC (-)Tj EMC (123 )Tj ET EMC /Span <>BDC BT 11 0 0 11 258.8186 366.065 Tm (thyroid )Tj ET EMC /Span <>BDC BT 11 0 0 11 258.8186 354.065 Tm (uptake and )Tj ET EMC /Span <>BDC BT 11 0 0 11 258.8186 342.065 Tm (scan)Tj ET EMC /Span <>BDC BT 11 0 0 11 330.6986 436.2023 Tm (Autonomously )Tj ET EMC /Span <>BDC BT 11 0 0 11 330.6986 424.2023 Tm (functioning \(hot\))Tj ET EMC /Span <>BDC BT 11 0 0 11 330.6986 339.4337 Tm (Hypofunctional)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 417.7236 434.2065 cm 0 0 m 10.119 0 l S Q q 1 0 0 1 433.3047 434.2065 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 413.1161 343.4379 cm 0 0 m 14.726 0 l S Q q 1 0 0 1 433.3047 343.4379 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 434.296 411.2663 cm 0 0 m 0 45.88 l S Q /Span <>BDC BT 11 0 0 11 436.456 448.2023 Tm (Evaluate and treat )Tj ET EMC /Span <>BDC BT 11 0 0 11 436.456 436.2023 Tm (for thyrotoxicosis )Tj ET EMC /Span <>BDC BT 11 0 0 11 436.456 424.2023 Tm (as indicated )Tj ET EMC /Span <>BDC BT 11 0 0 11 436.456 412.2023 Tm (\(malignancy is rare\))Tj ET EMC /Span <>BDC BT 9 0 0 9 540.3867 416.2023 Tm (c)Tj ET EMC q 1 0 0 1 434.296 263.0198 cm 0 0 m 0 105.88 l S Q /Span <>BDC BT 11 0 0 11 436.456 359.9558 Tm (Consider )Tj ET EMC /Span <>BDC BT 11 0 0 11 436.456 347.9558 Tm (ultrasound-guided )Tj ET EMC /Span <>BDC BT 11 0 0 11 436.456 335.9558 Tm [(FNA)36.9 ( based on )]TJ ET EMC /Span <>BDC BT 11 0 0 11 436.456 323.9558 Tm (clinical and )Tj ET EMC /Span <>BDC BT -0.019 Tw 11 0 0 11 436.456 311.9558 Tm [(sonographic )1.2 (features )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 436.456 299.9558 Tm (as described by the )Tj ET EMC /Span <>BDC BT 11 0 0 11 436.456 287.9558 Tm [(A)74 (T)74.4 (A)37 ( and/or TI)]TJ /Span<>> BDC (-)Tj EMC (RADS)Tj ET EMC /Span <>BDC BT 9 0 0 9 541.3535 291.9558 Tm (b)Tj ET EMC /Span <>BDC BT 11 0 0 11 436.456 275.9558 Tm (or )Tj ET EMC /Span <>BDC BT 11 0 0 11 436.456 263.9558 Tm (Nodule surveillance)Tj ET EMC /Span <>BDC BT 9 0 0 9 540.3813 267.9558 Tm (c)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 336.8186 361.2803 cm 0 0 m -12.3 20.789 l -0.131 41.565 l S Q q 1 0 0 1 339.6 356.5793 cm 0 0 m -1.375 7.334 l -5.767 4.736 l h f Q q 1 0 0 1 339.4479 407.5591 cm 0 0 m -5.746 -4.761 l -1.342 -7.34 l h f Q EMC 10 M q 1 0 0 1 706.4461 355.0172 cm 0 0 m 0 -93.88 l S Q /Span <>BDC BT 11 0 0 11 566.014 346.0729 Tm (Atypia of undetermined )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 566.014 334.0729 Tm <0056004c004a0051004c00bf00460044005100460048001200290052004f004f004c00460058004f004400550003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 566.014 322.0729 Tm (lesion of undetermined )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 566.014 310.0729 Tm <0056004c004a0051004c00bf00460044005100460048>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 566.014 298.0729 Tm (\(AUS/FLUS\) \(Bethesda III\) )Tj ET EMC /Span <>BDC BT 11 0 0 11 566.014 286.0729 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 566.014 274.0729 Tm (Follicular or Hürthle cell )Tj ET EMC /Span <>BDC BT 11 0 0 11 566.014 262.0729 Tm (neoplasm \(Bethesda IV\))Tj ET EMC q 1 0 0 1 701.5601 217.8877 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 11 0 0 11 566.0141 208.9434 Tm (Carcinoma or suspicious )Tj ET EMC /Span <>BDC BT 11 0 0 11 566.0141 196.9434 Tm (for carcinoma )Tj ET EMC /Span <>BDC BT 11 0 0 11 641.8163 196.9434 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 566.0141 184.9434 Tm (\(Bethesda V and VI\))Tj ET EMC q 1 0 0 1 674.6495 480.1466 cm 0 0 m 0 -81.88 l S Q /Span <>BDC BT 11 0 0 11 566.014 471.2023 Tm (Thyroid lymphoma)Tj ET EMC /Span <>BDC BT 11 0 0 11 566.014 459.2023 Tm (or)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 566.014 447.2023 Tm [<002c00510056005810880046004c00480051005700030045004c005200530056005c>75.1 <000f0003>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 566.014 435.2023 Tm (nondiagnostic )Tj ET EMC /Span <>BDC BT 11 0 0 11 566.014 423.2023 Tm (\(Bethesda I\))Tj ET EMC /Span <>BDC BT 11 0 0 11 566.014 411.2023 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 566.014 399.2023 Tm (Benign \(Bethesda II\))Tj ET EMC 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 722.0031 189.7779 cm 0 0 m 39.725 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 722.0031 202.9434 Tm (See )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 722.0031 190.9434 Tm (THYR)Tj /Span<>> BDC (-)Tj EMC (3)Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 719.8431 285.1368 cm 0 0 m 0 45.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 722.0031 308.9073 cm 0 0 m 39.725 0 l S Q q 1 0 0 1 722.0031 284.9073 cm 0 0 m 39.725 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 722.0031 322.0728 Tm (See )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 722.0031 310.0728 Tm (THYR)Tj /Span<>> BDC (-)Tj EMC (3)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 722.0031 298.0728 Tm (and )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 722.0031 286.0728 Tm (THYR)Tj /Span<>> BDC (-)Tj EMC (4)Tj ET EMC q 1 0 0 1 722.0031 428.0368 cm 0 0 m 39.725 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 722.0031 441.2023 Tm (See )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 722.0031 429.2023 Tm (THYR)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 755.61 429.2023 Tm (2)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 0.035 Tc -0.056 Tw 11 0 0 11 566.2074 514.3517 Tm [(FNA)54.3 ( RESUL)74.3 (TS)]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 704.2861 200.9476 cm 0 0 m 12.604 0 l S Q q 1 0 0 1 722.352 200.9476 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 708.76 308.077 cm 0 0 m 6.253 0 l S Q q 1 0 0 1 720.475 308.077 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 679.456 439.2065 cm 0 0 m 37.434 0 l S Q q 1 0 0 1 722.352 439.2065 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 562.3016 478.8253 cm 0 0 m 0 -297.731 l S Q EMC /Artifact <>BDC q 1 0 0 1 550.0865 332.9755 cm 0 0 m 6.253 0 l S Q q 1 0 0 1 561.8016 332.9755 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 548.5997 369.351 cm 0 0 m 0 -80.751 l S Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 474.2301 103.9223 cm 0 0 m 250.191 0 l S Q /Span <>BDC BT /GS0 gs /C2_0 1 Tf 0 Tc 0 Tw 11 0 0 11 474.2301 141.0878 Tm [<0027004c0044004a0051005200560057004c004600030046004400570048004a00520055004c0048005600030049005200550003002900310024>37.2 <00030055004800560058004f0057005600030055004800c0004800460057000300310026002c0003005600570044005700480003>]TJ ET EMC /Span <>BDC BT 11 0 0 11 474.2301 129.0878 Tm <0052004900030057004b0048000300560046004c004800510046004800030046005200510049004800550048005100460048000f00030057004b00480003002500480057004b004800560047004400030026004f004400560056004c00bf004600440057004c0052005100110003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 474.2301 117.0878 Tm [(Cibas ES and )37.7 (Ali SZ. Thyroid 2017;27\(1)55.6 (1\):1341-1346. )]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 474.2301 105.0878 Tm [(https://www)38.1 (.ncbi.nlm.nih.gov/pubmed/29091573)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 724.421 105.0878 Tm (. )Tj ET EMC /Span <>BDC BT 11 0 0 11 474.2301 93.0878 Tm (Cytology reports should be interpreted in light of )Tj ET EMC /Span <>BDC BT 11 0 0 11 474.2301 81.0878 Tm (terminology used by local cytopathologists.)Tj ET EMC 0 0 0 SCN 1 w 4 M 469.23 76.088 298.066 78.008 re S endstream endobj 231 0 obj 18785 endobj %% Contents for page 8 %% Original object ID: 17 0 232 0 obj << /Length 233 0 R >> stream Q q BT /Xi6 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 233 0 obj 244 endobj %% Original object ID: 313 0 234 0 obj << /BBox [ 0 612 792 0 ] /Matrix [ 1 0 0 1 0 0 ] /Resources << /ColorSpace << /CS0 166 0 R >> /ExtGState << /GS0 167 0 R >> /Font << /TT0 2135 0 R >> /ProcSet [ /PDF /Text ] >> /Subtype /Form /Length 235 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 8 0 0 8 28.544 54.27 Tm [(Note: )37.1 (All recommendations are category 2A)36.4 ( unless otherwise indicated.)]TJ ET EMC /Artifact <>BDC BT 8 0 0 8 28.544 44.67 Tm [(Clinical T)55.9 (rials: NCCN believes that the best management of any patient with cancer\ is in a clinical trial. Participation in clinical trials is especially \ encouraged.)]TJ ET EMC /CS0 CS 0 0 0 SCN 1 w 4 M 0 j 0 J 23.544 36.379 620.19 32.007 re S endstream endobj 235 0 obj 536 endobj %% Original object ID: 315 0 236 0 obj [ 2136 0 R 2137 0 R 2138 0 R 2139 0 R 2140 0 R 2141 0 R 2142 0 R ] endobj %% Contents for page 9 %% Original object ID: 18 0 237 0 obj << /Length 238 0 R >> stream q endstream endobj 238 0 obj 2 endobj %% Contents for page 9 %% Original object ID: 316 0 239 0 obj << /Length 240 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma)Tj ET EMC /Artifact <>BDC BT /TT1 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 0.035 Tc -0.053 Tw 11 0 0 11 23.2374 514.3517 Tm [(FNA)54.3 ( )0.7 (RESUL)74.2 (TS)]TJ ET EMC /Span <>BDC BT -0.035 Tw 11 0 0 11 331.2334 514.3517 Tm [(TREA)73.9 (TMENT)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 448.9917 Tm (Thyroid)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 436.9917 Tm (lymphoma)Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 124.5594 370.8381 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 23.544 361.8938 Tm [<002c00510056005810880046004c0048005100570003>24.4 <0045004c005200530056005c>74.6 <000f0003>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 23.544 349.8938 Tm (nondiagnostic )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 337.8938 Tm (\(Bethesda I\))Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 273.3257 Tm (Benign)Tj ET EMC /Span <>BDC BT 9 0 0 9 60.8194 277.3257 Tm (d)Tj ET EMC /Span <>BDC BT 11 0 0 11 66.317 273.3257 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 261.3257 Tm (\(Bethesda II\))Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 85.7027 446.9959 cm 0 0 m 233.555 0 l S Q q 1 0 0 1 324.72 446.9959 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 205.2113 383.8758 cm 0 0 m 114.046 0 l S Q q 1 0 0 1 324.72 383.8758 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 168.48 379.8717 Tm (Cystic)Tj ET EMC /Artifact <>BDC q 1 0 0 1 160.5266 329.8943 cm 0 0 m -34.258 24.004 l -0.376 47.986 l S Q q 1 0 0 1 165 326.76 cm 0 0 m -4.279 6.114 l -7.207 1.934 l h f Q q 1 0 0 1 164.6094 381.0359 cm 0 0 m -7.198 -1.968 l -4.249 -6.134 l h f Q EMC /Span <>BDC BT 11 0 0 11 168.48 320.3575 Tm (Solid)Tj ET EMC /Artifact <>BDC q 1 0 0 1 198.144 324.3616 cm 0 0 m 121.114 0 l S Q q 1 0 0 1 324.72 324.3616 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 328.88 301.4215 cm 0 0 m 0 45.88 l S Q /Span <>BDC BT 11 0 0 11 331.04 338.3575 Tm [(Repeat FNA)36.6 ( with ultrasound guidance and immediate )]TJ ET EMC /Span <>BDC BT 11 0 0 11 331.04 326.3575 Tm (cytologic review for adequacy of specimen \(preferred\))Tj ET EMC /Span <>BDC BT 11 0 0 11 331.04 314.3575 Tm (or )Tj ET EMC /Span <>BDC BT 11 0 0 11 331.04 302.3575 Tm (Consider surgery if repeat non-diagnostic FNAs)Tj ET EMC /Span <>BDC BT 11 0 0 11 331.04 379.8717 Tm (Correlate with ultrasound, re-aspirate suspicious areas)Tj ET EMC 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 331.04 441.8262 cm 0 0 m 233.691 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 331.04 442.9917 Tm [(See NCCN Guidelines for B-Cell L)37.7 (ymphomas)]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS0 gs q 1 0 0 1 92.88 271.3299 cm 0 0 m 226.378 0 l S Q 0 0 0 scn q 1 0 0 1 324.72 271.3299 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 331.04 267.3257 Tm [(Nodule surveillance as recommended by the )37.5 (A)74 (T)74.4 (A)36.9 ( or TI)]TJ /Span<>> BDC (-)Tj EMC (RADS)Tj ET EMC /Span <>BDC BT 9 0 0 9 648.8853 271.3257 Tm (b)Tj ET EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 75.6296 96.3964 cm 0 0 m 244.585 0 l S Q q 1 0 0 1 360.9617 96.3964 cm 0 0 m 345.005 0 l S Q /Span <>BDC BT /GS0 gs /TT1 1 Tf 8 0 0 8 23.7612 100.456 Tm (b)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm (TI-RADS \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 75.6296 97.456 Tm [(https://www)55.2 (.jacr)55.1 (.org/article/S1546-1440\(17\)301)-1.9 (86-2/pdf)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 320.2146 97.456 Tm [(\) or )55.3 (A)74.3 (T)74.3 (A)55.2 ( \()]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 360.9617 97.456 Tm [(https://www)55.2 (.ncbi.nlm.nih.gov/pmc/articles/PMC4739132/pdf/thy)72.2 (.2015.0020.pdf)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 705.9666 97.456 Tm (\).)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 89.456 Tm (d)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 86.456 Tm [(Includes nodular goiter)54.7 (, colloid nodule, hyperplastic/aden)-1.9 (omatoid nodule, and Hashimoto\222)15.9 (s thyroiditis. Estimated risk of malignancy is approximately 5% or less; ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 75.456 Tm (consider nodule surveillance.)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 727.3779 23.544 Tm [(THYR)17.3 (-)35 (2)]TJ ET EMC /GS1 gs q 1 0 0 1 28.544 177.6147 cm 0 0 m 250.191 0 l S Q /Span <>BDC BT /GS0 gs /C2_0 1 Tf 0 Tc 0 Tw 11 0 0 11 28.544 202.7803 Tm [<0027004c0044004a0051005200560057004c00460003>5.2 <0046004400570048004a00520055004c004800560003>4.7 <0049005200550003>5.1 <002900310024>36.9 <0003>5.1 <0055004800560058004f005700560003>4.7 <0055004800c00048004600570003>4.6 <00310026002c0003>4.9 <005600570044005700480003>4.6 <005200490003>5.2 <0057004b00480003>5 <00560046004c00480051004600480003>4.6 <0046005200510049004800550048005100460048000f0003>]TJ ET EMC /Span <>BDC BT 11 0 0 11 28.544 190.7803 Tm [<0057004b00480003002500480057004b004800560047004400030026004f004400560056004c00bf004600440057004c00520051001100030026004c00450044005600030028003600030044005100470003>37.9 <0024004f004c00030036003d001100030037004b005c00550052004c00470003001500130014001a001e0015001a000b0014>55.6 <0014000c001d0014001600170014>]TJ /Span<>> BDC <0010>Tj EMC <001400160017001900110003>Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs /TT0 1 Tf 11 0 0 11 28.544 178.7803 Tm [(https://www)38.1 (.ncbi.nlm.nih.gov/pubmed/29091573)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 278.7349 178.7803 Tm (. Cytology reports should be )Tj ET EMC /Span <>BDC BT 11 0 0 11 28.544 166.7803 Tm (interpreted in light of terminology used by local cytopathologists.)Tj ET EMC 0 0 0 SCN 1 w 4 M 23.544 161.78 433.849 54.008 re S endstream endobj 240 0 obj 8664 endobj %% Contents for page 9 %% Original object ID: 19 0 241 0 obj << /Length 242 0 R >> stream Q q BT /Xi7 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 242 0 obj 244 endobj %% Original object ID: 318 0 243 0 obj [ 2143 0 R 2144 0 R 2145 0 R 2146 0 R 2147 0 R 2148 0 R 2149 0 R 2150 0 R 2151 0 R 2152 0 R 2153 0 R 2154 0 R 2155 0 R 2156 0 R 2157 0 R 2158 0 R 2159 0 R 2160 0 R 2161 0 R ] endobj %% Contents for page 10 %% Original object ID: 20 0 244 0 obj << /Length 245 0 R >> stream q endstream endobj 245 0 obj 2 endobj %% Contents for page 10 %% Original object ID: 319 0 246 0 obj << /Length 247 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma)Tj ET EMC /Artifact <>BDC BT /TT1 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 727.3779 23.544 Tm [(THYR)17.3 (-)35 (3)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 97.0467 406.2984 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 24.3327 397.3541 Tm (Follicular or )Tj ET EMC /Span <>BDC BT 11 0 0 11 24.3327 385.3541 Tm (Hürthle cell )Tj ET EMC /Span <>BDC BT 11 0 0 11 24.3327 373.3541 Tm (neoplasm)Tj ET EMC /Span <>BDC BT 9 0 0 9 75.6803 377.3541 Tm (e,f)Tj ET EMC /Span <>BDC BT 11 0 0 11 86.1833 373.3541 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 24.3327 361.3541 Tm (\(Bethesda IV\))Tj ET EMC q 1 0 0 1 105.9989 320.256 cm 0 0 m 0 -105.88 l S Q /Span <>BDC BT 11 0 0 11 25.2 311.3117 Tm (Atypia of )Tj ET EMC /Span <>BDC BT 11 0 0 11 25.2 299.3117 Tm (undetermined )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 25.2 287.3117 Tm <0056004c004a0051004c00bf004600440051004600480012>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 25.2 275.3117 Tm (Follicular )Tj ET EMC /Span <>BDC BT 11 0 0 11 25.2 263.3117 Tm (lesion of )Tj ET EMC /Span <>BDC BT 11 0 0 11 25.2 251.3117 Tm (undetermined )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 25.2 239.3117 Tm <0056004c004a0051004c00bf00460044005100460048>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 9 0 0 9 88.7776 243.3117 Tm (f,g )Tj ET EMC /Span <>BDC BT 11 0 0 11 25.2 227.3117 Tm (\(AUS/FLUS\) )Tj ET EMC /Span <>BDC BT 11 0 0 11 25.2 215.3117 Tm (\(Bethesda III\))Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 101.0154 383.3582 cm 0 0 m 29.762 0 l S Q q 1 0 0 1 136.24 383.3582 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 139.0794 354.4181 cm 0 0 m 0 57.88 l S Q q 1 0 0 1 219.6 412.2984 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT 11 0 0 11 141.2394 403.3541 Tm (High clinical )Tj ET EMC /Span <>BDC BT 11 0 0 11 141.2394 391.3541 Tm (and/or )Tj ET EMC /Span <>BDC BT 11 0 0 11 141.2394 379.3541 Tm (radiographic)Tj ET EMC /Span <>BDC BT 11 0 0 11 207.8624 379.3541 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 141.2394 367.3541 Tm (suspicion of )Tj ET EMC /Span <>BDC BT 11 0 0 11 141.2394 355.3541 Tm (malignancy)Tj ET EMC /Span <>BDC BT 9 0 0 9 201.7609 359.3541 Tm (h)Tj ET EMC /Span <>BDC BT 11 0 0 11 285.2585 357.1585 Tm (No)Tj ET EMC 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 336.3327 436.248 cm 0 0 m 170.559 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 336.3327 437.4135 Tm [(See Primary T)54.8 (reatment \(ANAP-1\))]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS0 gs q 1 0 0 1 134.9545 444.1379 cm 0 0 m -31.229 24.68 l -0.122 49.352 l S Q 0 0 0 scn q 1 0 0 1 139.24 440.7512 cm 0 0 m -3.919 6.35 l -7.084 2.346 l h f Q q 1 0 0 1 139.112 496.8843 cm 0 0 m -7.08 -2.358 l -3.908 -6.357 l h f Q q 1 0 0 1 103.7447 468.8106 cm 0 0 m 22.993 0 l S Q q 1 0 0 1 132.1999 468.8106 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 336.3327 463.6481 cm 0 0 m 171.778 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 336.3327 464.8136 Tm [(See Primary T)54.8 (reatment \(MEDU-1)]TJ ET EMC /Span <>BDC BT 11 0 0 11 504.4479 464.8136 Tm (\))Tj ET EMC q 1 0 0 1 336.3327 496.0262 cm 0 0 m 161.192 0 l S Q /Span <>BDC BT 11 0 0 11 336.3327 497.1917 Tm [(See Primary T)54.8 (reatment \(P)73.7 (AP-1\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 0.035 Tc -0.056 Tw 11 0 0 11 24.526 514.3257 Tm [(FNA)54.3 ( RESUL)74.3 (TS)]TJ ET EMC /Span <>BDC BT -0.035 Tw 11 0 0 11 336.526 514.3257 Tm [(TREA)73.9 (TMENT)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 9 0 0 9 406.8229 518.3257 Tm (i)Tj ET EMC /GS1 gs q 1 0 0 1 684.8233 471.9478 cm 0 0 m 64.974 0 l S Q q 1 0 0 1 519.732 459.9478 cm 0 0 m 185.217 0 l S Q /Span <>BDC BT /GS0 gs /C2_0 1 Tf 11 0 0 11 519.732 509.1133 Tm [<0027004c0044004a0051005200560057004c004600030046004400570048004a00520055004c0048005600030049005200550003002900310024>37.2 <00030055004800560058004f0057005600030055004800c0004800460057>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 519.732 497.1133 Tm (NCI state of the science conference, the )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 519.732 485.1133 Tm [<002500480057004b004800560047004400030026004f004400560056004c00bf004600440057004c00520051001100030026004c00450044005600030028003600030044005100470003>37.7 <0024004f004c00030036003d00110003>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 519.732 473.1133 Tm [(Thyroid 2017;27\(1)54.8 (1\):1341-1346. )]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 684.8233 473.1133 Tm [(https://www)38.1 (.)]TJ ET EMC /Span <>BDC BT 11 0 0 11 519.732 461.1133 Tm (ncbi.nlm.nih.gov/pubmed/29091573)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 704.9488 461.1133 Tm (.)Tj ET EMC /Span <>BDC BT 11 0 0 11 519.732 449.1133 Tm (Cytology reports should be interpreted in light )Tj ET EMC /Span <>BDC BT 11 0 0 11 519.732 437.1133 Tm [(of )0.8 (terminology )1 (used )0.7 (by )0.7 (local )0.8 (cytopathologists.)]TJ ET EMC 0 0 0 SCN 1 w 4 M 514.732 432.113 253.224 90.008 re S 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 75.6296 200.3964 cm 0 0 m 244.585 0 l S Q q 1 0 0 1 360.9617 200.3964 cm 0 0 m 345.005 0 l S Q q 1 0 0 1 255.1853 147.8964 cm 0 0 m 47.061 0 l S Q /Span <>BDC BT /GS0 gs /TT1 1 Tf 8 0 0 8 23.7612 204.456 Tm (b)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 201.456 Tm (TI-RADS \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 75.6296 201.456 Tm [(https://www)55.2 (.jacr)55.1 (.org/article/S1546-1440\(17\)301)-1.9 (86-2/pdf)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 320.2146 201.456 Tm [(\) or )55.3 (A)74.3 (T)74.3 (A)55.2 ( \()]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 360.9617 201.456 Tm [(https://www)55.2 (.ncbi.nlm.nih.gov/pmc/articles/PMC4739132/pdf/thy)72.2 (.2015.0020.pdf)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 705.9666 201.456 Tm (\).)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 193.956 Tm (e)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 190.956 Tm [(Alternative term: Suspicious)-0.6 ( for follicular or Hürthle cell n)-1.7 (eoplasm. Estimated risk of malignancy is 15%\22640%. Numbers may vary by institution or cytopathologist.) ]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 183.456 Tm (f)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 180.456 Tm [(The diagnosis)-0.7 ( of follicular ca)-0.8 (rcinoma or Hürthle cell carcin)-1.7 (oma requires evidence of either vascular or capsular invasion, which cannot be determined by FNA. ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 169.956 Tm (Molecular diagnostics may be useful to allow reclassification of follicular lesions \(ie, follicular neoplasm, atypia of undetermined significance [AUS], follicular lesions of ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 159.456 Tm (undetermined significance [FLUS]\) as either more or less likely to be benign or malignant based on the genetic profile. If molecular testing suggests papillary thyroid ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 148.956 Tm (carcinoma, especially in the case of )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 10 0 0 10 190.156 148.956 Tm (BRAF)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 10 0 0 10 216.8259 148.956 Tm ( V600E, )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 255.1853 148.956 Tm (see )Tj ET EMC /Span <>BDC BT 10 0 0 10 274.0867 148.956 Tm [(P)74.2 (AP-1)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 302.2458 148.956 Tm (. If molecular testing, in conjunction with clinical and ultrasound features, predicts a risk of malignancy ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 138.456 Tm [(comparable to the risk of malignancy seen with a benign FNA)52.5 ( cytology \(approximately 5% or less\), consider nodule surveillance. Molecular markers should be ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 127.956 Tm (interpreted with caution and in the context of clinical, radiographic, and cytologic features of each individual patient.) Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 120.456 Tm (g)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 117.456 Tm [(Estimated risk of malignanc)-0.9 (y is 6%\22618% without NIFTP)17.4 ( and 10%\22630% with NIFTP)128.2 (.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 109.956 Tm (h)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 106.956 Tm [(Based on rapid growth of nodule, imaging, physical exam)-1.7 (, age, clinical history of radiation, and family history)72.2 (.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 99.456 Tm (i)Tj ET EMC /Span <>BDC BT /Span<>> BDC 8 0 0 8 25.5386 99.456 Tm ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 96.456 Tm [(The order of the treatment options does not indicate prefe)-1.3 (rence.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 88.956 Tm (j)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 85.956 Tm [(T)111 (otal thyroide)-0.7 (ctomy may be considered for)]TJ ET EMC /Span <>BDC BT 8 0 0 8 217.3874 88.956 Tm ( )Tj ET EMC /Span <>BDC BT 10 0 0 10 219.6101 85.956 Tm [(Hürthle cell ne)-1.1 (oplasm \(Bethesda IV\), history of radiation ex)-1.3 (posure, or contralateral lobe lesions.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 78.456 Tm (k)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 75.456 Tm [(Consid)-0.8 (er second opinion pa)-1.3 (thology)73.5 (.)]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 275.0979 243.2516 cm 0 0 m -53.543 24.064 l -0.582 48.109 l S Q q 1 0 0 1 280.08 241.0125 cm 0 0 m -5.35 5.202 l -7.442 0.547 l h f Q q 1 0 0 1 279.4898 293.6192 cm 0 0 m -7.44 -0.575 l -5.33 -5.222 l h f Q EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 285.2585 239.7617 Tm (No)Tj ET EMC /Span <>BDC BT -0.055 Tc 0.055 Tw 11 0 0 11 285.2585 293.3574 Tm [(Ye)-55.2 (s)]TJ ET EMC 10 M q 1 0 0 1 334.1727 214.8257 cm 0 0 m 0 57.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 519.8307 226.5962 cm 0 0 m 62.353 0 l S Q /Span <>BDC BT /GS0 gs 0 Tc 0 Tw 11 0 0 11 336.3327 263.7617 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 343.2399 263.7617 Tm (Repeat FNA)Tj ET EMC /Span <>BDC BT 9 0 0 9 405.5822 267.7617 Tm (k)Tj ET EMC /Span <>BDC BT 11 0 0 11 336.3327 251.7617 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 343.2399 251.7617 Tm (Consider diagnostic lobectomy )Tj ET EMC /Span <>BDC BT 11 0 0 11 510.0983 251.7617 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 343.5327 239.7617 Tm (\(if Bethesda III on 2 or more occasions\))Tj ET EMC /Span <>BDC BT 11 0 0 11 336.3327 227.7617 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 343.2399 227.7617 Tm (Consider molecular diagnostics)Tj ET EMC /Span <>BDC BT 9 0 0 9 510.1144 231.7617 Tm (f)Tj ET EMC /Span <>BDC BT 11 0 0 11 513.1115 227.7617 Tm ( \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 519.8307 227.7617 Tm (See THYR-4)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 582.1838 227.7617 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 336.3327 215.7617 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 343.2399 215.7617 Tm [(Consider nodule surveillance as recommended by the )38 (A)74 (T)74.4 (A)36.9 ( or TI)]TJ /Span<>> BDC (-)Tj EMC (RADS)Tj ET EMC /Span <>BDC BT 9 0 0 9 710.5905 219.7617 Tm (b)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 304.6985 243.7659 cm 0 0 m 23.478 0 l S Q q 1 0 0 1 333.639 243.7659 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 106.2788 267.3159 cm 0 0 m 24.499 0 l S Q q 1 0 0 1 136.24 267.3159 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 310.7309 297.3616 cm 0 0 m 17.446 0 l S Q q 1 0 0 1 333.639 297.3616 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 336.3327 299.3574 Tm (Consider lobectomy or total thyroidectomy)Tj ET EMC /Span <>BDC BT 9 0 0 9 561.2526 303.3574 Tm (j)Tj ET EMC /Span <>BDC BT 11 0 0 11 563.7531 299.3574 Tm ( )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 336.3326 287.3574 Tm <00490052005500030047004800bf0051004c0057004c0059004800030047004c0044004a005100520056004c00560012005700550048004400570050004800510057>Tj ET EMC 10 M q 1 0 0 1 103.1754 497.758 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT /TT0 1 Tf 11 0 0 11 23.5446 488.8137 Tm (Carcinoma or )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.5446 476.8137 Tm (suspicious )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.5446 464.8137 Tm (for carcinoma )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.5446 452.8137 Tm (\(Bethesda V )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.5446 440.8137 Tm (and VI\))Tj ET EMC /Span <>BDC BT 11 0 0 11 141.2394 503.1917 Tm (Papillary or suspicious )Tj ET EMC /Span <>BDC BT 11 0 0 11 141.2394 491.1917 Tm (for papillary)Tj ET EMC /Span <>BDC BT 11 0 0 11 141.2394 470.8136 Tm (Medullary or suspicious )Tj ET EMC /Span <>BDC BT 11 0 0 11 141.2394 458.8136 Tm (for medullary)Tj ET EMC /Span <>BDC BT 11 0 0 11 141.2394 443.4135 Tm (Anaplastic or suspicious )Tj ET EMC /Span <>BDC BT 11 0 0 11 141.2394 431.4135 Tm (for anaplastic)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 273.56 501.1959 cm 0 0 m 54.617 0 l S Q q 1 0 0 1 333.639 501.1959 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 273.56 468.8178 cm 0 0 m 54.617 0 l S Q q 1 0 0 1 333.639 468.8178 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 273.56 441.4177 cm 0 0 m 54.617 0 l S Q q 1 0 0 1 333.639 441.4177 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 275.0622 360.7963 cm 0 0 m -52.461 22.562 l -0.572 45.105 l S Q q 1 0 0 1 280.08 358.6383 cm 0 0 m -5.434 5.115 l -7.45 0.426 l h f Q q 1 0 0 1 279.5004 408.0783 cm 0 0 m -7.448 -0.454 l -5.415 -5.135 l h f Q EMC /Span <>BDC BT -0.055 Tc 0.055 Tw 11 0 0 11 285.2585 406.6455 Tm [(Ye)-55.2 (s)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 336.3327 412.6455 Tm (Consider lobectomy or total thyroidectomy)Tj ET EMC /Span <>BDC BT 9 0 0 9 561.2526 416.6455 Tm (j)Tj ET EMC /Span <>BDC BT 11 0 0 11 563.7531 412.6455 Tm ( )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 336.3326 400.6455 Tm <00490052005500030047004800bf0051004c0057004c0059004800030047004c0044004a005100520056004c00560012005700550048004400570050004800510057>Tj ET EMC /Artifact <>BDC q 1 0 0 1 310.7309 410.6497 cm 0 0 m 17.446 0 l S Q q 1 0 0 1 333.639 410.6497 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 334.1727 338.2225 cm 0 0 m 0 45.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 522.3312 361.993 cm 0 0 m 62.353 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 11 0 0 11 336.3327 375.1585 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 343.2399 375.1585 Tm (Consider diagnostic lobectomy)Tj ET EMC /Span <>BDC BT 11 0 0 11 336.3327 363.1585 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 343.2399 363.1585 Tm (Consider molecular diagnostics )Tj ET EMC /Span <>BDC BT 9 0 0 9 513.1705 367.1585 Tm (f )Tj ET EMC /Span <>BDC BT 11 0 0 11 518.6681 363.1585 Tm (\()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 522.3312 363.1585 Tm (See THYR-4)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 584.6842 363.1585 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 336.3326 351.1585 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 343.2399 351.1585 Tm (Consider nodule surveillance if low risk or patient )Tj ET EMC /Span <>BDC BT 11 0 0 11 343.5327 339.1585 Tm [(preference as recommended by the )36.4 (A)74.1 (T)74.4 (A)36.9 ( or TI)]TJ /Span<>> BDC (-)Tj EMC (RADS)Tj ET EMC /Span <>BDC BT 9 0 0 9 613.704 343.1585 Tm (b)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 304.6985 361.1627 cm 0 0 m 23.478 0 l S Q q 1 0 0 1 333.639 361.1627 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 704.1675 281.3033 cm 0 0 m 54.21 0 l S Q q 1 0 0 1 704.1675 269.3033 cm 0 0 m 61.123 0 l S Q q 1 0 0 1 704.1675 257.3033 cm 0 0 m 62.353 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 704.1675 282.4688 Tm [(See P)74.1 (AP-1)]TJ ET EMC /Span <>BDC BT 11 0 0 11 758.378 282.4688 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 704.1675 270.4688 Tm (See FOLL-1)Tj ET EMC /Span <>BDC BT 11 0 0 11 704.1675 258.4688 Tm [(See HÜRT)54.7 (-1)]TJ ET EMC q 1 0 0 1 704.1675 403.4758 cm 0 0 m 54.21 0 l S Q q 1 0 0 1 704.1675 391.4758 cm 0 0 m 61.123 0 l S Q q 1 0 0 1 704.1675 379.4758 cm 0 0 m 62.353 0 l S Q /Span <>BDC BT 11 0 0 11 704.1675 404.6413 Tm [(See P)74.1 (AP-1)]TJ ET EMC /Span <>BDC BT 11 0 0 11 758.3779 404.6413 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 704.1675 392.6413 Tm (See FOLL-1)Tj ET EMC /Span <>BDC BT 11 0 0 11 704.1675 380.6413 Tm [(See HÜRT)54.7 (-1)]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 702.6675 418.8796 cm 0 0 m 0 -44.468 l S Q EMC /Artifact <>BDC /GS0 gs q 1 0 0 1 702.6675 306.2483 cm 0 0 m 0 -63.551 l S Q EMC /Artifact <>BDC q 1 0 0 1 577.44 297.3616 cm 0 0 m 114.778 0 l S Q 0 0 0 scn q 1 0 0 1 697.68 297.3616 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 568.8 410.6497 cm 0 0 m 123.418 0 l S Q q 1 0 0 1 697.68 410.6497 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 139.0794 238.3757 cm 0 0 m 0 57.88 l S Q q 1 0 0 1 219.6 296.256 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT 11 0 0 11 141.2394 287.3117 Tm (High clinical )Tj ET EMC /Span <>BDC BT 11 0 0 11 141.2394 275.3117 Tm (and/or )Tj ET EMC /Span <>BDC BT 11 0 0 11 141.2394 263.3117 Tm (radiographic )Tj ET EMC /Span <>BDC BT 11 0 0 11 141.2394 251.3117 Tm (suspicion of )Tj ET EMC /Span <>BDC BT 11 0 0 11 141.2394 239.3117 Tm (malignancy)Tj ET EMC /Span <>BDC BT 9 0 0 9 201.7609 243.3117 Tm (h)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 509.7672 378.1667 cm 0 0 m 182.451 0 l S Q q 1 0 0 1 697.68 378.1667 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 514.232 255.2495 cm 0 0 m 177.986 0 l S Q q 1 0 0 1 697.68 255.2495 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC endstream endobj 247 0 obj 24322 endobj %% Contents for page 10 %% Original object ID: 21 0 248 0 obj << /Length 249 0 R >> stream Q q BT /Xi8 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 249 0 obj 244 endobj %% Original object ID: 320 0 250 0 obj << /BaseFont /EYXPCQ+Arial-ItalicMT /Encoding /WinAnsiEncoding /FirstChar 32 /FontDescriptor 2162 0 R /LastChar 121 /Subtype /TrueType /ToUnicode 2163 0 R /Type /Font /Widths [ 278 0 0 0 0 0 0 0 333 333 0 0 278 0 0 0 0 0 0 0 0 0 0 0 0 0 278 0 0 0 0 0 0 667 667 0 0 667 611 0 0 0 0 667 556 0 722 0 0 0 722 0 611 0 0 0 0 0 0 0 0 0 0 0 0 556 556 500 556 556 0 556 0 222 0 0 222 833 556 556 0 0 333 500 278 556 500 0 0 500 ] >> endobj %% Original object ID: 322 0 251 0 obj [ 2165 0 R 2166 0 R 2167 0 R 2168 0 R 2169 0 R 2170 0 R 2171 0 R ] endobj %% Contents for page 11 %% Original object ID: 22 0 252 0 obj << /Length 253 0 R >> stream q endstream endobj 253 0 obj 2 endobj %% Contents for page 11 %% Original object ID: 323 0 254 0 obj << /Length 255 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma)Tj ET EMC /Artifact <>BDC BT /TT1 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 727.3984 23.544 Tm [(THYR)17.6 (-)35.4 (4)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 520.4 277.2879 Tm (Nodule surveillance as recommended )Tj ET EMC /Span <>BDC BT 11 0 0 11 520.4 265.2879 Tm [(by the )37.4 (A)74.1 (T)74.4 (A)36.9 ( or TI)]TJ /Span<>> BDC (-)Tj EMC (RADS)Tj ET EMC /Span <>BDC BT 9 0 0 9 637.7262 269.2879 Tm (b)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 517.9561 398.9999 cm 0 0 m 0 -66.952 l S Q EMC /Span <>BDC BT 11 0 0 11 520.4 379.52 Tm (Consider lobectomy)Tj ET EMC /Span <>BDC BT 11 0 0 11 520.4 367.52 Tm (or)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 520.4 355.52 Tm [<0037>74.4 <005200570044004f00030057004b005c00550052004c004700480046005700520050005c000300490052005500030047004800bf0051004c0057004c005900480003>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 520.4 343.52 Tm (diagnosis/treatment)Tj ET EMC /Artifact <>BDC q 1 0 0 1 462.96 445.5113 cm 0 0 m 45.898 0 l S Q q 1 0 0 1 514.32 445.5113 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 149.1337 338.5959 Tm (Consider molecular )Tj ET EMC /Span <>BDC BT 11 0 0 11 149.1337 326.5959 Tm (diagnostics)Tj ET EMC /Span <>BDC BT 9 0 0 9 210.2568 330.5959 Tm (f)Tj ET EMC 10 M q 1 0 0 1 518.2401 422.5712 cm 0 0 m 0 45.88 l S Q /Span <>BDC BT 11 0 0 11 520.4 459.5072 Tm (Nodule surveillance)Tj ET EMC /Span <>BDC BT 9 0 0 9 624.3253 463.5072 Tm (b)Tj ET EMC /Span <>BDC BT 11 0 0 11 520.4 447.5072 Tm (or )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 520.4 435.5072 Tm <0026005200510056004c0047004800550003004f0052004500480046005700520050005c000300490052005500030047004800bf0051004c0057004c005900480003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 520.4 423.5072 Tm (diagnosis/treatment)Tj ET EMC /Span <>BDC BT 9 0 0 9 624.9215 427.5072 Tm (l)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 471.7361 394.9158 cm 0 0 m 37.122 0 l S Q q 1 0 0 1 514.32 394.9158 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 333.64 428.5712 cm 0 0 m 0 33.88 l S Q q 1 0 0 1 461.1881 462.4515 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 11 0 0 11 335.8 453.5072 Tm (Molecular diagnostics)Tj ET EMC /Span <>BDC BT 11 0 0 11 335.8 441.5072 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 342.7072 441.5072 Tm (Not done)Tj ET EMC /Span <>BDC BT 11 0 0 11 335.8 429.5072 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 342.7072 429.5072 Tm (Not informative)Tj ET EMC /Span <>BDC BT 0.033 Tc -0.033 Tw 11 0 0 11 520.5934 514.3517 Tm [(TREA)73.9 (TMENT)]TJ ET EMC 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 75.6296 173.3964 cm 0 0 m 244.585 0 l S Q q 1 0 0 1 360.9617 173.3964 cm 0 0 m 345.005 0 l S Q q 1 0 0 1 631.8845 129.3964 cm 0 0 m 47.061 0 l S Q /Span <>BDC BT /GS0 gs /TT1 1 Tf 0 Tc 0 Tw 8 0 0 8 23.7612 177.456 Tm (b)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 174.456 Tm (TI-RADS \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 75.6296 174.456 Tm [(https://www)55.2 (.jacr)55.1 (.org/article/S1546-1440\(17\)301)-1.9 (86-2/pdf)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 320.2146 174.456 Tm [(\) or )55.3 (A)74.3 (T)74.3 (A)55.2 ( \()]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 360.9617 174.456 Tm [(https://www)55.2 (.ncbi.nlm.nih.gov/pmc/articles/PMC4739132/pdf/thy)72.2 (.2015.0020.pdf)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 705.9666 174.456 Tm (\).)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 166.456 Tm (e)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 163.456 Tm [(Alternative term: Suspicious)-0.6 ( for follicular neoplasm. Estim)-1.4 (ated risk of malignancy is 15%\22640%. Numbers may vary by institution or cytopathologist.) ]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 155.456 Tm (f)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 152.456 Tm [(The diagnosis)-0.7 ( of follicular ca)-0.8 (rcinoma or Hürthle cell carcin)-1.7 (oma requires evidence of either vascular or capsular invasion, which cannot be determined by FNA. ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 141.456 Tm (Molecular diagnostics may be useful to allow reclassification of follicular lesions \(ie, follicular neoplasm,AUS, FLUS\) as either more or less likely to be benign or ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 130.456 Tm (malignant based on the genetic profile. If molecular testing suggests papillary thyroid carcinoma, especially in the case of ) Tj ET EMC /Span <>BDC BT /TT2 1 Tf 10 0 0 10 567.0359 130.456 Tm [(BRAF)18.1 ( )]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 10 0 0 10 596.3035 130.456 Tm (V600E, )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 631.8845 130.456 Tm (see )Tj ET EMC /Span <>BDC BT 10 0 0 10 650.7859 130.456 Tm [(P)74.2 (AP-1)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 678.9451 130.456 Tm (. If molecular )Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 119.456 Tm (testing, in conjunction with clinical and ultrasound features, predicts a risk of malignancy comparable to the risk of malignancy seen with a benign FNA) Tj 66.313 0 Td ( cytology )Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 108.456 Tm (\(approximately 5% or less\), consider nodule surveillance. Molecular markers should be interpreted with caution and in the context of clinical, radiographic, and ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm (cytologic features of each individual patient.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 89.456 Tm (g)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 86.456 Tm [(Estimated risk of malignanc)-0.9 (y is 6%\22618% without NIFTP)17.4 ( and 10%\22630% with NIFTP)128.2 (.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 78.456 Tm (l)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 75.456 Tm [(Clinica)-1 (l risk factors, sonographic patterns, and patient pre)-1 (ference can help determine whether nodule surveillance or lobectomy is appropriate.) ]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 97.0571 353.5402 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT /TT0 1 Tf 11 0 0 11 24.5 344.5959 Tm (Follicular)Tj ET EMC /Span <>BDC BT 11 0 0 11 24.5 332.5959 Tm (neoplasm)Tj ET EMC /Span <>BDC BT 9 0 0 9 75.8477 336.5959 Tm (e,f)Tj ET EMC /Span <>BDC BT 11 0 0 11 24.5 320.5959 Tm (\(Bethesda IV\))Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 97.875 336.6 cm 0 0 m 41.743 0 l S Q q 1 0 0 1 145.08 336.6 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M q 1 0 0 1 28.544 213.8424 cm 0 0 m 250.191 0 l S Q /Span <>BDC BT /GS0 gs /C2_0 1 Tf 11 0 0 11 28.544 239.0079 Tm [<0027004c0044004a0051005200560057004c00460003>4.6 <0046004400570048004a00520055004c004800560003>4.1 <0049005200550003>4.4 <002900310024>37 <0003>4.4 <0055004800560058004f005700560003>4.1 <0055004800c00048004600570003>4 <00310026002c0003>4.2 <005600570044005700480003>4 <005200490003>4.6 <0057004b00480003>4.4 <00560046004c00480051004600480003>4 <0046005200510049004800550048005100460048000f0003>]TJ ET EMC /Span <>BDC BT 11 0 0 11 28.544 227.0079 Tm [<0057004b00480003002500480057004b004800560047004400030026004f004400560056004c00bf004600440057004c00520051001100030026004c00450044005600030028003600030044005100470003>37.9 <0024004f004c00030036003d001100030037004b005c00550052004c00470003001500130014001a001e0015001a000b0014>55.6 <0014000c001d0014001600170014>]TJ /Span<>> BDC <0010>Tj EMC <001400160017001900110003>Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs /TT0 1 Tf 11 0 0 11 28.544 215.0079 Tm [(https://www)38.1 (.ncbi.nlm.nih.gov/pubmed/29091573)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 278.7349 215.0079 Tm (. Cytology reports should be )Tj ET EMC /Span <>BDC BT 11 0 0 11 28.544 203.0079 Tm (interpreted in light of terminology used by local cytopathologists.)Tj ET EMC 0 0 0 SCN 1 w 4 M 23.544 198.008 433.925 54.008 re S /Span <>BDC BT 11 0 0 11 24.5 447.5959 Tm (AUS/FLUS)Tj ET EMC /Span <>BDC BT 9 0 0 9 79.5 451.5959 Tm (f,g)Tj ET EMC /Span <>BDC BT 11 0 0 11 24.5 435.5959 Tm (\(Bethesda III\))Tj ET EMC 10 M q 1 0 0 1 146.9737 422.6598 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 266.3034 468.5401 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 11 0 0 11 149.1337 459.5958 Tm [(Repeat FNA)36.6 ( cytology)]TJ ET EMC /Span <>BDC BT 11 0 0 11 149.1337 447.5958 Tm (and/or)Tj ET EMC /Span <>BDC BT 11 0 0 11 149.1337 435.5958 Tm (Consider molecular )Tj ET EMC /Span <>BDC BT 11 0 0 11 149.1337 423.5958 Tm (diagnostics)Tj ET EMC /Span <>BDC BT 9 0 0 9 210.2568 427.5958 Tm (f)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 94.68 445.6 cm 0 0 m 44.938 0 l S Q q 1 0 0 1 145.08 445.6 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT /GS0 gs 11 0 0 11 335.8 396.9117 Tm (Molecular diagnostics )Tj ET EMC /Span <>BDC BT 11 0 0 11 335.8 384.9117 Tm (suggestive of malignancy)Tj ET EMC /Span <>BDC BT 11 0 0 11 335.8 277.2879 Tm (Molecular diagnostics )Tj ET EMC /Span <>BDC BT 11 0 0 11 335.8 265.2879 Tm (indicate benign lesion)Tj ET EMC /Span <>BDC BT 9 0 0 9 451.3161 269.2879 Tm (f)Tj ET EMC /Artifact <>BDC q 1 0 0 1 462.96 336.6 cm 0 0 m 45.898 0 l S Q q 1 0 0 1 514.32 336.6 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 462.96 275.2921 cm 0 0 m 45.898 0 l S Q q 1 0 0 1 514.32 275.2921 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 322.502 288.3862 cm 0 0 m -64.627 48.214 l -0.243 96.42 l S Q q 1 0 0 1 326.88 285.12 cm 0 0 m -4.095 6.238 l -7.146 2.148 l h f Q q 1 0 0 1 326.6313 388.08 cm 0 0 m -7.143 -2.16 l -4.084 -6.245 l h f Q q 1 0 0 1 258.9044 336.5862 cm 0 0 m 58.864 0 l S Q q 1 0 0 1 323.2307 336.5862 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 335.8 494.9117 Tm (Molecular diagnostics )Tj ET EMC /Span <>BDC BT 11 0 0 11 335.8 482.9117 Tm (indicate benign lesion)Tj ET EMC /Span <>BDC BT 9 0 0 9 451.3161 486.9117 Tm (f)Tj ET EMC /Artifact <>BDC q 1 0 0 1 462.96 492.9158 cm 0 0 m 45.898 0 l S Q q 1 0 0 1 514.32 492.9158 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 520.4 488.9117 Tm (Nodule surveillance)Tj ET EMC /Span <>BDC BT 9 0 0 9 624.3253 492.9117 Tm (b)Tj ET EMC /Span <>BDC BT 0.035 Tc -0.017 Tw 11 0 0 11 23.2374 514.3517 Tm [(MOLECULAR)17.2 ( )0.6 (DIAGNOSTIC)17.2 ( )0.6 (RESUL)74.2 (TS)]TJ ET EMC 10 M q 1 0 0 1 331.4752 319.6599 cm 0 0 m 0 33.88 l S Q q 1 0 0 1 459.0233 353.5402 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 333.6352 344.5959 Tm (Molecular diagnostics)Tj ET EMC /Span <>BDC BT 11 0 0 11 333.6352 332.5959 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 340.5424 332.5959 Tm (Not done)Tj ET EMC /Span <>BDC BT 11 0 0 11 333.6352 320.5959 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 340.5424 320.5959 Tm (Not informative)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 322.581 403.6095 cm 0 0 m -53.574 41.991 l -0.203 83.973 l S Q q 1 0 0 1 326.88 400.24 cm 0 0 m -3.945 6.334 l -7.093 2.317 l h f Q q 1 0 0 1 326.6714 490.96 cm 0 0 m -7.089 -2.33 l -3.934 -6.341 l h f Q q 1 0 0 1 269.7637 445.588 cm 0 0 m 48.588 0 l S Q q 1 0 0 1 323.8137 445.588 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC endstream endobj 255 0 obj 15679 endobj %% Contents for page 11 %% Original object ID: 23 0 256 0 obj << /Length 257 0 R >> stream Q q BT /Xi9 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 257 0 obj 244 endobj %% Original object ID: 325 0 258 0 obj [ 2172 0 R 2173 0 R 2174 0 R 2175 0 R 2176 0 R 2177 0 R 2178 0 R 2179 0 R 2180 0 R ] endobj %% Contents for page 12 %% Original object ID: 24 0 259 0 obj << /Length 260 0 R >> stream q endstream endobj 260 0 obj 2 endobj %% Contents for page 12 %% Original object ID: 326 0 261 0 obj << /Length 262 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Papillary Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 23.2374 514.3517 Tm [(FNA)54.3 ( )]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.2374 502.3517 Tm [(RESUL)74.2 (TS)]TJ ET EMC /Span <>BDC BT 11 0 0 11 158.3477 514.3517 Tm [(DIAGNOSTIC)17.2 ( )]TJ ET EMC /Span <>BDC BT 11 0 0 11 158.3477 502.3517 Tm (PROCEDURES)Tj ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 347.6457 514.3517 Tm [(PREOPERA)73.9 (TIVE)17.4 ( )0.6 (OR)17.3 ( )]TJ ET EMC /Span <>BDC BT -0.035 Tw 11 0 0 11 347.6457 502.3517 Tm [(INTRAOPERA)73.9 (TIVE)17.4 ( )]TJ ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 347.6457 490.3517 Tm [(DECISION)17.3 (-)17.4 (MAKING)17.6 ( )0.6 (CRITERIA)]TJ ET EMC /Span <>BDC BT -0.094 Tw 11 0 0 11 547.3589 514.3517 Tm [(PRIMAR)36.8 (Y)35.5 ( TREA)73.9 (TMENT)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 88.9786 298.4118 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.044 289.4675 Tm (Papillary )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.044 277.4675 Tm (carcinoma )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.044 265.4675 Tm (or )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.044 253.4675 Tm (suspicious )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.044 241.4675 Tm (for papillary )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.044 229.4675 Tm (carcinoma)Tj ET EMC /Span <>BDC BT 9 0 0 9 78.0709 233.4675 Tm (a)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 137.3349 332.0759 cm 0 0 m 11.03 0 l S Q q 1 0 0 1 153.8268 332.0759 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 155.9943 255.1357 cm 0 0 m 0 165.88 l S Q q 1 0 0 1 318.96 421.016 cm 0 0 m 0 -165.88 l S Q /Span <>BDC BT 11 0 0 11 158.1543 412.0717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 165.0616 412.0717 Tm (Thyroid and neck ultrasound )Tj ET EMC /Span <>BDC BT 11 0 0 11 165.3543 400.0717 Tm (\(including central and )Tj ET EMC /Span <>BDC BT 11 0 0 11 165.3543 388.0717 Tm (lateral compartments\), if not )Tj ET EMC /Span <>BDC BT 11 0 0 11 165.3543 376.0717 Tm (previously done)Tj ET EMC /Span <>BDC BT 11 0 0 11 158.1543 364.0717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 165.0616 364.0717 Tm (CT/MRI with contrast for )Tj ET EMC /Span <>BDC BT 11 0 0 11 165.3543 352.0717 Tm (locally advanced disease or )Tj ET EMC /Span <>BDC BT 11 0 0 11 165.3543 340.0717 Tm (vocal cord paresis)Tj ET EMC /Span <>BDC BT 9 0 0 9 261.9588 344.0717 Tm (b)Tj ET EMC /Span <>BDC BT 11 0 0 11 158.1543 328.0717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 165.0615 328.0717 Tm (Consider evaluation of vocal )Tj ET EMC /Span <>BDC BT 11 0 0 11 165.3543 316.0717 Tm (cord mobility \(ultrasound, )Tj ET EMC /Span <>BDC BT -0.025 Tw 11 0 0 11 165.3543 304.0717 Tm [(mirror indirect laryngoscopy)74.4 (, )]TJ ET EMC /Span <>BDC BT /C2_0 1 Tf 0 Tw 11 0 0 11 165.3543 292.0717 Tm <00520055000300bf004500480055005200530057004c00460003004f00440055005c0051004a00520056004600520053005c000c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 307.7635 296.0717 Tm (c)Tj ET EMC /Span <>BDC BT 11 0 0 11 158.1543 280.0717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 165.0615 280.0717 Tm [(Strongly consider FNA)37.6 ( for )]TJ ET EMC /Span <>BDC BT 11 0 0 11 165.3543 268.0717 Tm (suspicious lateral neck )Tj ET EMC /Span <>BDC BT 11 0 0 11 165.3543 256.0717 Tm (nodes)Tj ET EMC /Span <>BDC BT 9 0 0 9 197.7474 260.0717 Tm (d)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 339.8963 306.1273 cm 0 0 m -19.591 25.949 l -0.209 51.881 l S Q q 1 0 0 1 343.1875 301.7681 cm 0 0 m -2.189 7.134 l -6.262 4.059 l h f Q q 1 0 0 1 342.9568 362.3837 cm 0 0 m -6.242 -4.089 l -2.154 -7.145 l h f Q EMC 10 M q 1 0 0 1 345.2924 340.1399 cm 0 0 m 0 141.88 l S Q q 1 0 0 1 522.8495 482.0202 cm 0 0 m 0 -141.88 l S Q 0.75 w q 1 0 0 1 429.9631 459.9103 cm 0 0 m 18.955 0 l S Q /Span <>BDC BT 11 0 0 11 347.4524 473.0759 Tm (Indications for total )Tj ET EMC /Span <>BDC BT 11 0 0 11 347.4524 461.0759 Tm (thyroidectomy \()Tj ET EMC /Span <>BDC BT 11 0 0 11 429.9631 461.0759 Tm (any)Tj ET EMC /Span <>BDC BT 11 0 0 11 448.9177 461.0759 Tm ( present\):)Tj ET EMC /Span <>BDC BT 11 0 0 11 347.4524 449.0759 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 354.3596 449.0759 Tm (Known distant metastases)Tj ET EMC /Span <>BDC BT 11 0 0 11 347.4524 437.0759 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 354.3596 437.0759 Tm (Extrathyroidal extension )Tj ET EMC /Span <>BDC BT 11 0 0 11 347.4524 425.0759 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 354.3596 425.0759 Tm [<0037>74.4 <00580050005200550003002100170003004600500003004c005100030047004c0044005000480057004800550003>]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 347.4524 413.0759 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 354.3596 413.0759 Tm (Cervical lymph node )Tj ET EMC /Span <>BDC BT 11 0 0 11 354.6524 401.0759 Tm (metastases or gross central )Tj ET EMC /Span <>BDC BT 11 0 0 11 354.6524 389.0759 Tm (neck lymph node metastases)Tj ET EMC /Span <>BDC BT 11 0 0 11 347.4524 377.0759 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 354.3596 377.0759 Tm <0033005200520055004f005c00030047004c108700480055004800510057004c0044005700480047>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 347.4524 365.0759 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 354.3596 365.0759 Tm (Consider for prior radiation )Tj ET EMC /Span <>BDC BT 11 0 0 11 354.6524 353.0759 Tm (exposure \(category 2B\))Tj ET EMC /Span <>BDC BT 11 0 0 11 347.4524 341.0759 Tm <9520>Tj ET EMC /Span <>BDC BT -0.016 Tw 11 0 0 11 354.3596 341.0759 Tm [(Consider for bilateral nod)0.5 (ularity)]TJ ET EMC /Artifact <>BDC 1 w 4 M q 1 0 0 1 524.9542 411.08 cm 0 0 m 12.12 0 l S Q q 1 0 0 1 542.5364 411.08 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 345.2923 234.9509 cm 0 0 m 0 81.88 l S Q q 1 0 0 1 542.4453 316.8312 cm 0 0 m 0 -81.88 l S Q 0.75 w q 1 0 0 1 347.4523 294.7213 cm 0 0 m 11 0 l S Q q 1 0 0 1 431.5905 294.7213 cm 0 0 m 12.23 0 l S Q /Span <>BDC BT 0 Tw 11 0 0 11 347.4523 307.8869 Tm (Indications for total thyroidectomy )Tj ET EMC /Span <>BDC BT 11 0 0 11 347.4523 295.8869 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 358.4523 295.8869 Tm [( lobectomy)74.4 (, if )]TJ ET EMC /Span <>BDC BT 11 0 0 11 431.5905 295.8869 Tm (all)Tj ET EMC /Span <>BDC BT 11 0 0 11 443.8205 295.8869 Tm ( criteria present:)Tj ET EMC /Span <>BDC BT 11 0 0 11 347.4523 283.8869 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 354.3596 283.8869 Tm (No prior radiation exposure)Tj ET EMC /Span <>BDC BT 11 0 0 11 347.4523 271.8869 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 354.3596 271.8869 Tm (No distant metastases)Tj ET EMC /Span <>BDC BT 11 0 0 11 347.4523 259.8869 Tm <9520>Tj ET EMC /Span <>BDC BT -0.012 Tw 11 0 0 11 354.3596 259.8869 Tm [(No )0.5 (cervical lymph )0.7 (node )0.8 (metastases)]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 347.4523 247.8869 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 354.3596 247.8869 Tm (No extrathyroidal extension )Tj ET EMC /Span <>BDC BT 11 0 0 11 347.4523 235.8869 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 354.3596 235.8869 Tm [(T)74.4 (umor 1\2264 cm in diameter )]TJ ET EMC 1 w q 1 0 0 1 545.0056 376.1399 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 684.72 446.0202 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT 11 0 0 11 547.1655 437.0759 Tm [(T)74.4 (otal thyroidectomy )]TJ ET EMC /Span <>BDC BT 11 0 0 11 547.1655 425.0759 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 554.0728 425.0759 Tm (Perform therapeutic )Tj ET EMC /Span <>BDC BT 11 0 0 11 554.3655 413.0759 Tm (neck dissection of )Tj ET EMC /Span <>BDC BT 11 0 0 11 554.3655 401.0759 Tm (involved compartments )Tj ET EMC /Span <>BDC BT 11 0 0 11 554.3655 389.0759 Tm (for clinically apparent/)Tj ET EMC /Span <>BDC BT 11 0 0 11 554.3655 377.0759 Tm (biopsy-proven disease)Tj ET EMC /Span <>BDC BT 9 0 0 9 673.5716 381.0759 Tm (e)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 685.8 411.08 cm 0 0 m 9.288 0 l S Q q 1 0 0 1 700.5497 411.08 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 701.82 388.1398 cm 0 0 m 0 45.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 703.98 387.9103 cm 0 0 m 38.908 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 703.98 425.0758 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 703.98 413.0758 Tm (Postsurgical )Tj ET EMC /Span <>BDC BT 11 0 0 11 703.98 401.0758 Tm (Evaluation )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 703.98 389.0758 Tm [(\(P)74.2 (AP-4\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 8 0 0 8 23.544 144.3872 Tm (a)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 141.3872 Tm [(There is a potential role for l)-0.6 (obectomy with or without frozen section if FNA)55.1 ( is )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 130.3872 Tm (suspicious but not diagnostic for papillary carcinoma.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 122.3872 Tm (b)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 119.3872 Tm [(Use of iodina)-0.8 (ted contrast is required for optimal cervical i)-1.6 (maging using CT)109.8 (; )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 108.3872 Tm (potential delay in RAI treatment will not cause harm.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 100.3872 Tm (c)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 97.3872 Tm [(V)55.2 (ocal cord mobility may be examined in patients with abn)-1.7 (ormal voice, surgical )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 86.3872 Tm (history involving the recurrent laryngeal or vagus nerves, invasive disease, or ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.304 75.3872 Tm (bulky disease of the central neck.)Tj ET EMC /Span <>BDC BT 8 0 0 8 400.5 122.3872 Tm (d)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 406.26 119.3872 Tm [(Tg washout is useful in diag)-1 (nosis of lymph node metasta)-0.8 (ses and recommended if )]TJ ET EMC /Span <>BDC BT 10 0 0 10 406.26 108.3872 Tm (cytology is negative.)Tj ET EMC /Span <>BDC BT 8 0 0 8 400.5 100.3872 Tm (e)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 406.26 97.3872 Tm [(Routin)-0.6 (e prophylactic central)-0.6 ( neck dissection is not indicat)-1.2 (ed in most papillary )]TJ ET EMC /Span <>BDC BT 10 0 0 10 406.26 86.3872 Tm (thyroid cancers.)Tj ET EMC /Span <>BDC BT 8 0 0 8 400.5 78.3872 Tm (f)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 406.26 75.3872 Tm [(Posterior location, abutting the trachea or apparaent inva)-1.5 (sion, etc.)]TJ ET EMC /Span <>BDC BT /TT1 1 Tf -0.039 Tc 0.039 Tw 11 0 0 11 735.9072 23.544 Tm [(PA)-74.4 (P)-56.5 (-)-39 (1)]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 543.4178 275.8911 cm 0 0 m 12.12 0 l S Q q 1 0 0 1 561 275.8911 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 566.1655 270.7213 cm 0 0 m 54.21 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 0 Tc 0 Tw 11 0 0 11 566.1655 271.8869 Tm [(See P)74.1 (AP)]TJ /Span<>> BDC (-)Tj EMC (2)Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 545.0056 191.3908 cm 0 0 m 0 33.88 l S Q /Span <>BDC BT 0 0 0 scn 11 0 0 11 547.1655 216.3268 Tm (Active surveillance with ultrasound)Tj ET EMC /Span <>BDC BT 11 0 0 11 547.1655 204.3268 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 547.1655 192.3268 Tm (Lobectomy if high risk)Tj ET EMC /Span <>BDC BT 9 0 0 9 664.5132 196.3268 Tm (f)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 103.8389 328.0717 Tm <00950014000300460050>Tj ET EMC /Span <>BDC BT 11 0 0 11 103.8389 191.3268 Tm <001f0014000300460050>Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 107.5411 214.9409 cm 0 0 m -16.927 48.531 l -0.173 97.056 l S Q q 1 0 0 1 109.3399 209.7834 cm 0 0 m 0.1 7.461 l -4.719 5.781 l h f Q q 1 0 0 1 109.1511 317.16 cm 0 0 m -4.701 -5.796 l 0.123 -7.461 l h f Q EMC /Artifact <>BDC q 1 0 0 1 137.3349 195.331 cm 0 0 m 11.03 0 l S Q q 1 0 0 1 153.8268 195.331 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 155.9943 172.3908 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 310.7793 218.2711 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT /TT1 1 Tf -0.015 Tw 11 0 0 11 158.1543 209.3268 Tm [(Thyroid )0.7 (and neck ultrasound )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 158.1543 197.3268 Tm (\(including central and )Tj ET EMC /Span <>BDC BT 11 0 0 11 158.1543 185.3268 Tm (lateral compartments\), if not )Tj ET EMC /Span <>BDC BT 11 0 0 11 158.1543 173.3268 Tm (previously done)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 506.16 208.331 cm 0 0 m 30.914 0 l S Q q 1 0 0 1 542.5364 208.331 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 347.4523 204.3268 Tm (No concerning lymph node\(s\))Tj ET EMC /Span <>BDC BT 11 0 0 11 347.4523 174.3206 Tm (Concerning lymph node\(s\))Tj ET EMC /Artifact <>BDC q 1 0 0 1 670.8 196.8786 cm 0 0 m 12.12 0 l S Q q 1 0 0 1 688.3822 196.8786 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 693.5477 191.7089 cm 0 0 m 54.21 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 693.5477 192.8744 Tm [(See P)74.1 (AP)]TJ /Span<>> BDC (-)Tj EMC (2)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS0 gs q 1 0 0 1 339.0817 183.5743 cm 0 0 m -26.071 11.757 l -0.305 23.494 l S Q 0 0 0 scn q 1 0 0 1 344.0609 181.3289 cm 0 0 m -5.343 5.209 l -7.441 0.557 l h f Q q 1 0 0 1 343.7478 209.3331 cm 0 0 m -7.439 -0.585 l -5.323 -5.229 l h f Q EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 547.1655 174.3206 Tm <0030004400510044004a00480003004400560003009500140003004600500003000b0056004800480003005300440057004b005a0044005c000300440045005200590048000c>Tj ET EMC /Artifact <>BDC q 1 0 0 1 489.6 178.3248 cm 0 0 m 47.474 0 l S Q q 1 0 0 1 542.5364 178.3248 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC endstream endobj 262 0 obj 19234 endobj %% Contents for page 12 %% Original object ID: 25 0 263 0 obj << /Length 264 0 R >> stream Q q BT /Xi10 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 264 0 obj 245 endobj %% Original object ID: 328 0 265 0 obj [ 2181 0 R 2182 0 R 2183 0 R 2184 0 R 2185 0 R 2186 0 R 2187 0 R 2188 0 R 2189 0 R 2190 0 R 2191 0 R 2192 0 R 2193 0 R ] endobj %% Contents for page 13 %% Original object ID: 26 0 266 0 obj << /Length 267 0 R >> stream q endstream endobj 267 0 obj 2 endobj %% Contents for page 13 %% Original object ID: 329 0 268 0 obj << /Length 269 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Papillary Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.094 Tw 11 0 0 11 123.3882 514.3517 Tm [(PRIMAR)36.8 (Y)35.5 ( TREA)73.9 (TMENT)]TJ ET EMC /Span <>BDC BT -0.039 Tc 0.039 Tw 11 0 0 11 735.9072 23.544 Tm [(PA)-74.4 (P)-56.5 (-)-39 (2)]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 259.7027 294.6263 cm 0 0 m -31.441 32.134 l -0.336 64.248 l S Q q 1 0 0 1 263.5228 290.7222 cm 0 0 m -3.08 6.797 l -6.728 3.228 l h f Q q 1 0 0 1 263.1672 362.798 cm 0 0 m -6.712 -3.262 l -3.046 -6.812 l h f Q EMC 10 M q 1 0 0 1 265.2028 328.8115 cm 0 0 m 0 105.88 l S Q q 1 0 0 1 503.28 434.6918 cm 0 0 m 0 -105.88 l S Q 0.75 w q 1 0 0 1 267.3628 424.582 cm 0 0 m 105.096 0 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 267.3628 425.7475 Tm (Any of the following)Tj ET EMC /Span <>BDC BT 11 0 0 11 372.459 425.7475 Tm (:)Tj ET EMC /Span <>BDC BT 11 0 0 11 267.3628 413.7475 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 274.27 413.7475 Tm [<0037>74.4 <0058005000520055000300210017000300460050>]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 267.3628 401.7475 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 274.27 401.7475 Tm (Gross positive resection margins)Tj ET EMC /Span <>BDC BT 11 0 0 11 267.3628 389.7475 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 274.27 389.7475 Tm (Gross extrathyroidal extension )Tj ET EMC /Span <>BDC BT 11 0 0 11 267.3628 377.7475 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 274.27 377.7475 Tm <003000440046005500520056004600520053004c0046000300500058004f0057004c0049005200460044004f00030047004c005600480044005600480003000b002100030014000300460050000c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 267.3628 365.7475 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 274.27 365.7475 Tm <00260052005100bf00550050004800470003004600520051005700550044004f00440057004800550044004f00030047004c00560048004400560048>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 267.3628 353.7475 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 274.27 353.7475 Tm <00260052005100bf005500500048004700030051005200470044004f000300500048005700440056005700440056004c0056>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 421.583 357.7475 Tm (g)Tj ET EMC /Span <>BDC BT 11 0 0 11 267.3628 341.7475 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 274.27 341.7475 Tm [(V)55.2 (ascular invasion )]TJ ET EMC /Span <>BDC BT 11 0 0 11 267.3628 329.7475 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 274.27 329.7475 Tm <0033005200520055004f005c00030047004c108700480055004800510057004c0044005700480047>Tj ET EMC 1 w q 1 0 0 1 265.2028 220.8199 cm 0 0 m 0 81.88 l S Q q 1 0 0 1 419.9362 302.7002 cm 0 0 m 0 -81.88 l S Q 0.75 w q 1 0 0 1 267.3628 292.5903 cm 0 0 m 98.372 0 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 267.3628 293.7559 Tm (All of the following)Tj ET EMC /Span <>BDC BT 11 0 0 11 365.7344 293.7559 Tm (:)Tj ET EMC /Span <>BDC BT 11 0 0 11 267.3628 281.7559 Tm <9520>Tj ET EMC /Span <>BDC BT -0.007 Tw 11 0 0 11 274.27 281.7559 Tm (Negative resection margins )Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 267.3628 269.7559 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 274.27 269.7559 Tm (No contralateral lesion)Tj ET EMC /Span <>BDC BT 11 0 0 11 267.3628 257.7559 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 274.27 257.7559 Tm [<0037>74.4 <00580050005200550003001f00140003004600500003004c005100030047004c004400500048005700480055>]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 267.3628 245.7559 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 274.27 245.7559 Tm (No suspicious lymph node)Tj ET EMC /Span <>BDC BT 11 0 0 11 267.3628 233.7559 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 267.3628 221.7559 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 274.27 221.7559 Tm (NIFTP)Tj ET EMC /Span <>BDC BT 9 0 0 9 306.0454 225.7559 Tm (h)Tj ET EMC /Artifact <>BDC 1 w 4 M q 1 0 0 1 504.36 381.7518 cm 0 0 m 37.285 0 l S Q q 1 0 0 1 547.1068 381.7518 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 423.36 261.7601 cm 0 0 m 39.741 0 l S Q q 1 0 0 1 468.5628 261.7601 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 715.7637 370.582 cm 0 0 m 38.908 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 657.0845 383.7476 Tm (See Postsurgical )Tj ET EMC /Span <>BDC BT 11 0 0 11 657.0845 371.7476 Tm (Evaluation )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 715.7637 371.7476 Tm [(\(P)74.2 (AP-4\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 551.52 383.7475 Tm (Completion of )Tj ET EMC /Span <>BDC BT 11 0 0 11 551.52 371.7475 Tm (thyroidectomy)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 628.8028 381.7517 cm 0 0 m 19.474 0 l S Q q 1 0 0 1 653.7388 381.7517 cm 0 0 m -7.012 -2.552 l -7.012 2.552 l h f Q EMC 10 M q 1 0 0 1 470.2508 220.8199 cm 0 0 m 0 81.88 l S Q q 1 0 0 1 623.9628 302.7002 cm 0 0 m 0 -81.88 l S Q /Span <>BDC BT 11 0 0 11 472.4108 293.7559 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 479.318 293.7559 Tm (Consider thyroglobulin )Tj ET EMC /Span <>BDC BT 11 0 0 11 479.6108 281.7559 Tm (measurement and anti-Tg )Tj ET EMC /Span <>BDC BT 11 0 0 11 479.6108 269.7559 Tm (antibodies 6\22612 wks )Tj ET EMC /Span <>BDC BT 11 0 0 11 479.6108 257.7559 Tm (post-op)Tj ET EMC /Span <>BDC BT 9 0 0 9 519.9316 261.7559 Tm (i)Tj ET EMC /Span <>BDC BT 11 0 0 11 472.4108 245.7559 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 479.318 245.7559 Tm (Consider levothyroxine )Tj ET EMC /Span <>BDC BT 11 0 0 11 479.6108 233.7559 Tm (therapy to keep TSH low or )Tj ET EMC /Span <>BDC BT 11 0 0 11 479.6108 221.7559 Tm (normal)Tj ET EMC /Span <>BDC BT 9 0 0 9 516.2846 225.7559 Tm (j)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 628.8028 261.76 cm 0 0 m 19.474 0 l S Q q 1 0 0 1 653.7388 261.76 cm 0 0 m -7.012 -2.552 l -7.012 2.552 l h f Q EMC 10 M q 1 0 0 1 654.9245 244.8199 cm 0 0 m 0 33.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 726.769 244.5903 cm 0 0 m 38.908 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 657.0845 269.7559 Tm (See Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 657.0845 257.7559 Tm (Monitoring and )Tj ET EMC /Span <>BDC BT 11 0 0 11 657.0845 245.7559 Tm (Maintenance )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 726.769 245.7559 Tm [(\(P)74.2 (AP-8\))]TJ ET EMC q 1 0 0 1 29.5212 118.3964 cm 0 0 m 48.73 0 l S Q q 1 0 0 1 29.5212 74.3964 cm 0 0 m 202.666 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 8 0 0 8 23.7612 133.456 Tm (g)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 130.456 Tm [(Completion thyroidectomy is)-0.6 ( not required for incidental small volume pathologic N1A)51.7 ( metastases \(<5 involved nodes with no metastasis >5 mm in largest dimension\). ) ]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 119.456 Tm [(See P)74.1 (AP-)]TJ ET EMC /Span <>BDC BT 10 0 0 10 72.6902 119.456 Tm (5)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 78.2517 119.456 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 111.456 Tm (h)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 108.456 Tm [(Formerly calle)-0.6 (d encapsulate)-0.9 (d follicular variant of PTC, no)-0.7 (ninvasive follicular thyroid neoplasm with papillary-like nuclear features \(NIFTP\) has been reclassified and ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm (only lobectomy is needed. Ongoing surveillance is recommended.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 89.456 Tm (i)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 86.456 Tm [(May be useful for obtaining )-0.8 (a postoperative baseline. )]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 78.456 Tm (j)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 75.456 Tm [(See Principle)-0.8 (s of )18.2 (TSH Suppression \(THYR-A\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 232.1872 75.456 Tm (.)Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 120.3176 308.8157 cm 0 0 m 0 165.88 l S Q /Span <>BDC BT /TT1 1 Tf -0.02 Tw 11 0 0 11 122.4776 465.7517 Tm [(T)74.4 (otal thyroidectomy )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 122.4776 453.7517 Tm (\(category 2B\))Tj ET EMC /Span <>BDC BT 11 0 0 11 122.4776 393.7517 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 122.4776 333.7517 Tm (Lobectomy )Tj ET EMC /Span <>BDC BT 11 0 0 11 122.4776 321.7517 Tm (+ isthmusectomy)Tj ET EMC /Span <>BDC BT 9 0 0 9 212.6475 325.7517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 122.4776 309.7517 Tm (\(category 2B\))Tj ET EMC q 1 0 0 1 101.4251 420.696 cm 0 0 m 0 -57.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 26.7071 362.5862 cm 0 0 m 54.21 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 23.044 411.7517 Tm [(T)74.4 (otal )]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.044 399.7517 Tm (thyroidectomy )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.044 387.7517 Tm (or lobectomy )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.044 375.7517 Tm (indicated )Tj ET EMC /Span <>BDC BT 11 0 0 11 74.3863 375.7517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.044 363.7517 Tm (\()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 26.7071 363.7517 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 49.3355 363.7517 Tm [(P)74.2 (AP)]TJ /Span<>> BDC (-)Tj EMC (1)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 80.9175 363.7517 Tm (\))Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 228.0638 473.7601 cm 0 0 m 0 -23.541 l S Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 326.042 450.8198 cm 0 0 m 38.908 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 267.3628 463.9854 Tm (See Postsurgical )Tj ET EMC /Span <>BDC BT 11 0 0 11 267.3628 451.9854 Tm (Evaluation )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 326.042 451.9854 Tm [(\(P)74.2 (AP-4\))]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS0 gs q 1 0 0 1 230.3533 461.9895 cm 0 0 m 27.707 0 l S Q 0 0 0 scn q 1 0 0 1 263.5227 461.9895 cm 0 0 m -7.012 -2.552 l -7.012 2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 228.0638 343.1948 cm 0 0 m 0 -32.87 l S Q EMC /Artifact <>BDC q 1 0 0 1 101.2651 391.7559 cm 0 0 m 11.818 0 l S Q q 1 0 0 1 118.5451 391.7559 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC endstream endobj 269 0 obj 14807 endobj %% Contents for page 13 %% Original object ID: 27 0 270 0 obj << /Length 271 0 R >> stream Q q BT /Xi11 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 271 0 obj 245 endobj %% Original object ID: 331 0 272 0 obj [ 2194 0 R 2195 0 R 2196 0 R 2197 0 R 2198 0 R 2199 0 R 2200 0 R 2201 0 R 2202 0 R 2203 0 R 2204 0 R 2205 0 R 2206 0 R 2207 0 R ] endobj %% Contents for page 14 %% Original object ID: 28 0 273 0 obj << /Length 274 0 R >> stream q endstream endobj 274 0 obj 2 endobj %% Contents for page 14 %% Original object ID: 332 0 275 0 obj << /Length 276 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Papillary Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf -0.043 Tc 0.043 Tw 11 0 0 11 736.1005 23.544 Tm [(P)0.5 (A)-74 (P)-56.1 (-)-38.7 (3)]TJ ET EMC /Span <>BDC BT 0.035 Tc -0.052 Tw 11 0 0 11 23.7373 514.3517 Tm [(CLINICAL)35.6 ( PRESENT)74.2 (A)73.9 (TION)]TJ ET EMC /Span <>BDC BT -0.091 Tw 11 0 0 11 447.1924 514.3517 Tm [(PRIMAR)36.8 (Y)35.5 ( )0.5 (TREA)73.9 (TMENT)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 92.16 309.3001 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 24.5446 300.3558 Tm (Papillary )Tj ET EMC /Span <>BDC BT 11 0 0 11 24.5446 288.3558 Tm (carcinoma )Tj ET EMC /Span <>BDC BT 11 0 0 11 24.5446 276.3558 Tm (found post)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 24.5446 264.3558 Tm (lobectomy )Tj ET EMC q 1 0 0 1 134.04 233.4199 cm 0 0 m 0 105.88 l S Q q 1 0 0 1 256.8 339.3002 cm 0 0 m 0 -105.88 l S Q /Span <>BDC BT 11 0 0 11 136.2 330.3559 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 143.1072 330.3559 Tm (Thyroid and )Tj ET EMC /Span <>BDC BT 11 0 0 11 143.4 318.3559 Tm (neck ultrasound )Tj ET EMC /Span <>BDC BT 11 0 0 11 143.4 306.3559 Tm (\(including central )Tj ET EMC /Span <>BDC BT 11 0 0 11 143.4 294.3559 Tm (and lateral )Tj ET EMC /Span <>BDC BT 11 0 0 11 143.4 282.3559 Tm (compartments\), if )Tj ET EMC /Span <>BDC BT 11 0 0 11 143.4 270.3559 Tm (not previously done)Tj ET EMC /Span <>BDC BT 11 0 0 11 136.2 258.3559 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 143.1072 258.3559 Tm (Biopsy suspicious )Tj ET EMC /Span <>BDC BT 11 0 0 11 143.4 246.3559 Tm (lymph nodes or )Tj ET EMC /Span <>BDC BT 11 0 0 11 143.4 234.3559 Tm (contralateral lesions)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 96.5833 286.36 cm 0 0 m 31.155 0 l S Q q 1 0 0 1 133.2 286.36 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 279.3518 185.1397 cm 0 0 m -21.8 101.22 l -0.079 202.44 l S Q q 1 0 0 1 280.5018 179.8 cm 0 0 m 1.018 7.392 l -3.971 6.318 l h f Q q 1 0 0 1 280.4191 392.92 cm 0 0 m -3.966 -6.321 l 1.024 -7.392 l h f Q q 1 0 0 1 257.5959 286.3322 cm 0 0 m 13.717 0 l S Q q 1 0 0 1 276.7749 286.3322 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 285.96 337.6557 cm 0 0 m 0 165.88 l S Q q 1 0 0 1 420.84 503.536 cm 0 0 m 0 -165.88 l S Q 0.75 w q 1 0 0 1 288.12 493.4261 cm 0 0 m 105.096 0 l S Q /Span <>BDC BT 11 0 0 11 288.12 494.5917 Tm (Any of the following)Tj ET EMC /Span <>BDC BT 11 0 0 11 393.2162 494.5917 Tm (:)Tj ET EMC /Span <>BDC BT 11 0 0 11 288.12 482.5917 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 295.0272 482.5917 Tm [<0037>74.4 <0058005000520055000300210017000300460050>]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 288.12 470.5917 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 295.0272 470.5917 Tm (Gross positive )Tj ET EMC /Span <>BDC BT 11 0 0 11 295.32 458.5917 Tm (resection margins)Tj ET EMC /Span <>BDC BT 11 0 0 11 288.12 446.5917 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 295.0272 446.5917 Tm (Gross extra-thyroidal )Tj ET EMC /Span <>BDC BT 11 0 0 11 295.32 434.5917 Tm (extension )Tj ET EMC /Span <>BDC BT 11 0 0 11 288.12 422.5917 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 295.0272 422.5917 Tm (Macroscopic multifocal )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 295.32 410.5917 Tm <0047004c005600480044005600480003000b00210014000300460050000c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 288.12 398.5917 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 295.0272 398.5917 Tm <00260052005100bf005500500048004700030051005200470044004f0003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 295.32 386.5917 Tm (metastasis)Tj ET EMC /Span <>BDC BT 9 0 0 9 352.1891 390.5917 Tm (g)Tj ET EMC /Span <>BDC BT 11 0 0 11 357.6867 386.5917 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 288.12 374.5917 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 295.0272 374.5917 Tm [<00260052005100bf00550050004800470003>39.3 <004600520051005700550044004f00440057004800550044004f0003>]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 295.32 362.5917 Tm (disease)Tj ET EMC /Span <>BDC BT 11 0 0 11 288.12 350.5917 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 295.0272 350.5917 Tm [(V)55.2 (ascular invasion )]TJ ET EMC /Span <>BDC BT 11 0 0 11 288.12 338.5917 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 295.0272 338.5917 Tm <0033005200520055004f005c00030047004c108700480055004800510057004c0044005700480047>Tj ET EMC 1 w q 1 0 0 1 285.48 269.4199 cm 0 0 m 0 33.88 l S Q q 1 0 0 1 429.6597 303.3002 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 287.64 294.3559 Tm [(T)74.4 (umor 1\2264 cm in diameter )]TJ ET EMC /Span <>BDC BT 11 0 0 11 287.64 282.3559 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 287.64 270.3559 Tm [(L)37.3 (ymphatic invasion)]TJ ET EMC q 1 0 0 1 285.4442 140.6427 cm 0 0 m 0 105.88 l S Q q 1 0 0 1 429.6597 246.523 cm 0 0 m 0 -105.88 l S Q 0.75 w q 1 0 0 1 287.6042 236.4132 cm 0 0 m 98.372 0 l S Q /Span <>BDC BT 11 0 0 11 287.6042 237.5787 Tm (All of the following)Tj ET EMC /Span <>BDC BT 11 0 0 11 385.9758 237.5787 Tm (:)Tj ET EMC /Span <>BDC BT 11 0 0 11 287.6042 225.5787 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 294.5115 225.5787 Tm (Negative resection )Tj ET EMC /Span <>BDC BT 11 0 0 11 294.8043 213.5787 Tm (margins )Tj ET EMC /Span <>BDC BT 11 0 0 11 287.6042 201.5787 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 294.5115 201.5787 Tm (No contralateral lesion)Tj ET EMC /Span <>BDC BT 11 0 0 11 287.6042 189.5787 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 294.5115 189.5787 Tm [<0037>74.4 <00580050005200550003001f00140003004600500003004c005100030047004c004400500048005700480055>]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 287.6042 177.5787 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 294.5115 177.5787 Tm (No suspicious lymph )Tj ET EMC /Span <>BDC BT 11 0 0 11 294.8043 165.5787 Tm (node)Tj ET EMC /Span <>BDC BT 11 0 0 11 287.6042 153.5787 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 287.6042 141.5787 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 294.5115 141.5787 Tm (NIFTP)Tj ET EMC /Span <>BDC BT 9 0 0 9 326.2869 145.5787 Tm (h)Tj ET EMC /Artifact <>BDC 1 w 4 M q 1 0 0 1 427.08 420.5959 cm 0 0 m 11.138 0 l S Q q 1 0 0 1 443.68 420.5959 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 431 286.36 cm 0 0 m 7.218 0 l S Q q 1 0 0 1 443.68 286.36 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 431 193.5829 cm 0 0 m 8.218 0 l S Q q 1 0 0 1 444.68 193.5829 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 445.3396 391.6557 cm 0 0 m 0 57.88 l S Q q 1 0 0 1 648.72 449.536 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT 11 0 0 11 447.4996 440.5917 Tm (Completion of thyroidectomy )Tj ET EMC /Span <>BDC BT 11 0 0 11 447.4996 428.5917 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 454.4069 428.5917 Tm (Perform therapeutic neck dissection )Tj ET EMC /Span <>BDC BT 11 0 0 11 454.6996 416.5917 Tm (of involved compartments for )Tj ET EMC /Span <>BDC BT 11 0 0 11 454.6996 404.5917 Tm (clinically apparent/biopsy-proven )Tj ET EMC /Span <>BDC BT 11 0 0 11 454.6996 392.5917 Tm (disease)Tj ET EMC q 1 0 0 1 446.3396 251.4198 cm 0 0 m 0 93.88 l S Q /Span <>BDC BT 11 0 0 11 448.4996 336.3558 Tm (Completion of )Tj ET EMC /Span <>BDC BT 11 0 0 11 448.4996 324.3558 Tm (thyroidectomy )Tj ET EMC /Span <>BDC BT 11 0 0 11 448.4996 300.3558 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 448.4996 276.3558 Tm (Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 448.4996 264.3558 Tm (monitoring)Tj ET EMC /Span <>BDC BT 9 0 0 9 505.9327 268.3558 Tm (k)Tj ET EMC /Span <>BDC BT 9 0 0 9 510.9381 268.3558 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 448.4996 252.3558 Tm (\(category 2B\))Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 529.92 256.7059 cm 0 0 m 19.628 0 l S Q q 1 0 0 1 555.01 256.7059 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 651.42 420.5959 cm 0 0 m 25.998 0 l S Q q 1 0 0 1 682.88 420.5959 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 531 332.6 cm 0 0 m 146.418 0 l S Q q 1 0 0 1 682.88 332.6 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 447.4996 195.5787 Tm (Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 447.4996 183.5787 Tm (monitoring)Tj ET EMC /Span <>BDC BT 9 0 0 9 504.9327 187.5787 Tm (k)Tj ET EMC /Artifact <>BDC q 1 0 0 1 521.28 193.5829 cm 0 0 m 27.758 0 l S Q q 1 0 0 1 554.5 193.5829 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 558.4 227.7657 cm 0 0 m 0 57.88 l S Q q 1 0 0 1 645.22 285.646 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT 11 0 0 11 560.5599 276.7017 Tm (Consider )Tj ET EMC /Span <>BDC BT 11 0 0 11 560.5599 264.7017 Tm (levothyroxine )Tj ET EMC /Span <>BDC BT 11 0 0 11 560.5599 252.7017 Tm (therapy to keep )Tj ET EMC /Span <>BDC BT 11 0 0 11 560.5599 240.7017 Tm (TSH low or )Tj ET EMC /Span <>BDC BT 11 0 0 11 560.5599 228.7017 Tm (normal)Tj ET EMC /Span <>BDC BT 9 0 0 9 597.2338 232.7017 Tm (j)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 651.42 256.7059 cm 0 0 m 25.998 0 l S Q q 1 0 0 1 682.88 256.7059 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 558.4 170.6427 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 666.7599 216.523 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 11 0 0 11 560.5599 207.5787 Tm (Consider )Tj ET EMC /Span <>BDC BT 11 0 0 11 560.5599 195.5787 Tm (levothyroxine )Tj ET EMC /Span <>BDC BT 11 0 0 11 560.5599 183.5787 Tm (therapy to keep )Tj ET EMC /Span <>BDC BT 11 0 0 11 560.5599 171.5787 Tm (TSH low or normal)Tj ET EMC /Span <>BDC BT 9 0 0 9 657.7338 175.5787 Tm (j)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 666.6 193.5829 cm 0 0 m 10.818 0 l S Q q 1 0 0 1 682.88 193.5829 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 689.4996 360.9279 cm 0 0 m 38.908 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 689.4996 398.0934 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 689.4996 386.0934 Tm (Postsurgical )Tj ET EMC /Span <>BDC BT 11 0 0 11 689.4996 374.0934 Tm (Evaluation )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 689.4996 362.0934 Tm [(\(P)74.2 (AP-4\))]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS0 gs q 1 0 0 1 685.8797 459.3552 cm 0 0 m 0 -150.515 l S Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 689.4996 192.9082 cm 0 0 m 38.908 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 689.4996 242.0738 Tm (See Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 689.4996 230.0738 Tm (Monitoring )Tj ET EMC /Span <>BDC BT 11 0 0 11 689.4996 218.0738 Tm (and )Tj ET EMC /Span <>BDC BT 11 0 0 11 689.4996 206.0738 Tm (Maintenance )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 689.4996 194.0738 Tm [(\(P)74.2 (AP-8\))]TJ ET EMC q 1 0 0 1 83.989 118.3964 cm 0 0 m 48.73 0 l S Q q 1 0 0 1 29.5212 85.3964 cm 0 0 m 202.666 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 8 0 0 8 23.7612 133.456 Tm (g)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 130.456 Tm [(Completion of thyroidectomy)-0.7 ( is not required for incidental)-1.7 ( small volume pathologic N1A)53.2 ( metastases \(<5 involved nodes with no metastasis >5 mm in largest )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 119.456 Tm (dimension\). )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 83.989 119.456 Tm [(See P)74.1 (AP-5)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 132.7195 119.456 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 111.456 Tm (h)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 108.456 Tm [(Formerly calle)-0.6 (d encapsulate)-0.9 (d follicular variant of PTC, no)-0.7 (ninvasive follicular thyroid neoplasm with papillary-like nuclear features \(NIFTP\) has been reclassified and ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm (only lobectomy is needed. Ongoing surveillance is recommended.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 89.456 Tm (j)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 86.456 Tm [(See Principle)-0.8 (s of )18.2 (TSH Suppression \(THYR-A\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 232.1872 86.456 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 78.456 Tm (k)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 75.456 Tm [(Measurement of thyroglobul)-0.7 (in and antithyroglobulin antib)-2.2 (odies may be useful for obtaining a postoperative baseline. )]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 524.54 343.8399 cm 0 0 m 0 -24.48 l S Q EMC /Artifact <>BDC q 1 0 0 1 524.54 286.0558 cm 0 0 m 0 -58.7 l S Q EMC /Artifact <>BDC q 1 0 0 1 686.8797 264.3558 cm 0 0 m 0 -84.556 l S Q EMC endstream endobj 276 0 obj 18275 endobj %% Contents for page 14 %% Original object ID: 29 0 277 0 obj << /Length 278 0 R >> stream Q q BT /Xi12 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 278 0 obj 245 endobj %% Original object ID: 334 0 279 0 obj [ 2208 0 R 2209 0 R 2210 0 R 2211 0 R 2212 0 R 2213 0 R 2214 0 R 2215 0 R 2216 0 R 2217 0 R 2218 0 R 2219 0 R ] endobj %% Contents for page 15 %% Original object ID: 30 0 280 0 obj << /Length 281 0 R >> stream q endstream endobj 281 0 obj 2 endobj %% Contents for page 15 %% Original object ID: 335 0 282 0 obj << /Length 283 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Papillary Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf -0.039 Tc 0.039 Tw 11 0 0 11 735.9071 23.544 Tm [(PA)-74.4 (P)-56.5 (-)-39 (4)]TJ ET EMC 1 1 1 scn /GS1 gs 23.544 514.352 219.816 8.008 re f /Span <>BDC BT 0 0 0 scn /GS0 gs 0.035 Tc -0.017 Tw 11 0 0 11 23.7374 514.3511 Tm [(POSTSURGICAL)35.7 ( )0.6 (EV)74.1 (ALUA)73.9 (TION)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.802 498.2717 Tm (No gross residual )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.802 486.2717 Tm (disease in neck)Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 68.1445 432.7917 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 11 0 0 11 23.544 423.8474 Tm (Gross )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 411.8474 Tm (residual )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 399.8474 Tm (disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 387.8474 Tm (in neck)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 166.4944 375.2518 cm 0 0 m -14.598 34.6 l -0.15 69.192 l S Q q 1 0 0 1 168.6177 370.2192 cm 0 0 m -0.375 7.453 l -5.077 5.469 l h f Q q 1 0 0 1 168.4491 449.4838 cm 0 0 m -5.057 -5.487 l -0.348 -7.454 l h f Q EMC /Span <>BDC BT 11 0 0 11 136.1 459.3159 Tm (Resectable)Tj ET EMC /Span <>BDC BT 11 0 0 11 136.1 340.2389 Tm (Unresectable)Tj ET EMC /Span <>BDC BT 9 0 0 9 205.1884 344.2389 Tm (l)Tj ET EMC /Artifact <>BDC q 1 0 0 1 200.8667 463.32 cm 0 0 m 12.178 0 l S Q q 1 0 0 1 218.5067 463.32 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 219.5067 465.3159 Tm (Resect, if)Tj ET EMC /Span <>BDC BT 11 0 0 11 219.5067 453.3159 Tm (possible)Tj ET EMC /Artifact <>BDC q 1 0 0 1 283.7047 453.4893 cm 0 0 m -9.897 9.831 l -0.119 19.642 l S Q q 1 0 0 1 287.58 449.64 cm 0 0 m -3.177 6.752 l -6.773 3.131 l h f Q q 1 0 0 1 287.4411 476.9999 cm 0 0 m -6.757 -3.166 l -3.143 -6.768 l h f Q EMC /Span <>BDC BT 11 0 0 11 290.58 483.8963 Tm (No gross )Tj ET EMC /Span <>BDC BT 11 0 0 11 290.58 471.8963 Tm (residual disease)Tj ET EMC /Artifact <>BDC q 1 0 0 1 376.78 481.9005 cm 0 0 m 18.458 0 l S Q q 1 0 0 1 400.7 481.9005 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 123.9452 496.2759 cm 0 0 m 271.551 0 l S Q q 1 0 0 1 400.958 496.2759 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 290.58 443.4963 Tm (Gross residual)Tj ET EMC /Span <>BDC BT 11 0 0 11 367.6122 443.4963 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 290.58 431.4963 Tm ( disease)Tj ET EMC /Artifact <>BDC q 1 0 0 1 328.3282 426.1899 cm 0 0 m 0 -13.428 l S Q q 1 0 0 1 328.3282 407.2997 cm 0 0 m 2.552 7.012 l -2.552 7.012 l h f Q EMC 10 M q 1 0 0 1 233.0336 273.3029 cm 0 0 m 0 129.88 l S Q q 1 0 0 1 372.093 403.1833 cm 0 0 m 0 -129.88 l S Q /Span <>BDC BT 11 0 0 11 235.1936 394.239 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 242.1008 394.239 Tm (TSH + Tg measurement )Tj ET EMC /Span <>BDC BT 11 0 0 11 367.2984 394.239 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 382.239 Tm (+ antithyroglobulin )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 370.239 Tm (antibodies \(6\22612 wks )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 358.239 Tm (postoperatively\))Tj ET EMC /Span <>BDC BT 11 0 0 11 235.1936 346.239 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 242.1008 346.239 Tm (Iodine)Tj /Span<>> BDC (-)Tj EMC (123 or iodine)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 242.3936 334.239 Tm (131)Tj ET EMC /Span <>BDC BT 9 0 0 9 260.7466 338.239 Tm (m )Tj ET EMC /Span <>BDC BT 11 0 0 11 271.2496 334.239 Tm (total body )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 322.239 Tm (radioiodine imaging )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 310.239 Tm (with TSH stimulation )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 298.239 Tm (\(thyroid hormone )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 286.239 Tm (withdrawal)Tj ET EMC /Span <>BDC BT 9 0 0 9 299.2359 290.239 Tm (n)Tj ET EMC /Span <>BDC BT 11 0 0 11 304.7335 286.239 Tm (\) \(category )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 274.239 Tm (2B\))Tj ET EMC q 1 0 0 1 386.98 378.1219 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 453.86 424.0022 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 11 0 0 11 389.14 415.0579 Tm (Suspected )Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 403.0579 Tm (or proven )Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 391.0579 Tm (inadequate )Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 379.0579 Tm (RAI uptake)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 454.7145 401.0621 cm 0 0 m 3.503 0 l S Q q 1 0 0 1 463.68 401.0621 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 463.54 366.1219 cm 0 0 m 0 81.88 l S Q /Span <>BDC BT 11 0 0 11 465.7 439.0579 Tm (Monitoring of residual disease)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 427.0579 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 415.0579 Tm (Consider)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 403.0579 Tm (External beam RT/intensity)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 465.7 391.0579 Tm (modulated RT \(EBRT/IMRT\) )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 379.0579 Tm (if disease is threatening vital )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 367.0579 Tm (structures)Tj ET EMC /Span <>BDC BT 9 0 0 9 519.4969 371.0579 Tm (o)Tj ET EMC q 1 0 0 1 386.98 272.1316 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 449.02 342.0119 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT 11 0 0 11 389.14 333.0676 Tm (Adequate )Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 321.0676 Tm (RAI uptake)Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 309.0676 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 297.0676 Tm (No RAI )Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 285.0676 Tm (imaging )Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 273.0676 Tm (performed)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 449.568 307.0718 cm 0 0 m 7.786 0 l S Q q 1 0 0 1 462.816 307.0718 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 463.54 278.1316 cm 0 0 m 0 57.88 l S Q /Span <>BDC BT 11 0 0 11 465.7 327.0676 Tm <9520>Tj ET EMC /Span <>BDC BT -0.025 Tw 11 0 0 11 472.6072 327.0676 Tm [(Radioiodine )1.1 (treatment \(preferred\))]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 465.7 315.0676 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 472.6072 315.0676 Tm (Post-treatment iodine)Tj /Span<>> BDC (-)Tj EMC (131 whole )Tj ET EMC /Span <>BDC BT 11 0 0 11 472.9 303.0676 Tm (body imaging)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 291.0676 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 472.6072 291.0676 Tm (TSH)Tj /Span<>> BDC (-)Tj EMC (stimulated Tg)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 279.0676 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 472.6072 279.0676 Tm (Consider EBRT/IMRT)Tj ET EMC /Span <>BDC BT 9 0 0 9 583.2195 283.0676 Tm (o)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 651.734 447.0662 cm 0 0 m 0 -327.703 l S Q EMC /Artifact <>BDC q 1 0 0 1 652.234 283.2147 cm 0 0 m 12.048 0 l S Q q 1 0 0 1 669.744 283.2147 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 670.1716 242.2744 cm 0 0 m 0 81.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 679.5316 242.0449 cm 0 0 m 38.908 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 672.3316 315.2104 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 679.2388 315.2104 Tm (Suppress )Tj ET EMC /Span <>BDC BT 11 0 0 11 679.5316 303.2104 Tm (TSH with )Tj ET EMC /Span <>BDC BT 11 0 0 11 679.5316 291.2104 Tm (levothyroxine)Tj ET EMC /Span <>BDC BT 9 0 0 9 751.0531 295.2104 Tm (j)Tj ET EMC /Span <>BDC BT 11 0 0 11 672.3316 279.2104 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 679.2388 279.2104 Tm (See Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 679.5316 267.2104 Tm (Monitoring and )Tj ET EMC /Span <>BDC BT 11 0 0 11 679.5316 255.2104 Tm (Maintenance )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 679.5316 243.2104 Tm [(\(P)74.2 (AP-8\))]TJ ET EMC q 1 0 0 1 29.5212 118.3964 cm 0 0 m 202.666 0 l S Q q 1 0 0 1 29.5212 74.3964 cm 0 0 m 245.474 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 8 0 0 8 23.7612 122.456 Tm (j)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 119.456 Tm [(See Principle)-0.8 (s of )18.2 (TSH Suppression \(THYR-A\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 232.1872 119.456 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 111.456 Tm (l)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 108.456 Tm [(For bulky)74.2 (, locoregional, visc)-1 (erally invasive disease or rap)-1.9 (id progression, refer to high)]TJ /Span<>> BDC (-)Tj EMC (volume multidisciplinary institution, including radiation oncology referral.) Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 100.456 Tm (m )Tj ET EMC /Span <>BDC BT 10 0 0 10 32.6479 97.456 Tm (If considering dosimetry iodine)Tj /Span<>> BDC (-)Tj EMC (131 is the preferred agent.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 89.456 Tm (n )Tj ET EMC /Span <>BDC BT 10 0 0 10 30.4331 86.456 Tm (For contraindications to withdrawal, thyrotropin alfa may be used.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 78.456 Tm (o)Tj ET EMC /Span <>BDC BT /Span<>> BDC 8 0 0 8 28.2104 78.456 Tm ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 75.456 Tm [(See Principle)-0.8 (s of Radiation )-0.8 (and RAI )18.1 (Therapy \(THYR)]TJ /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 274.9949 75.456 Tm (.)Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 405.5287 478.9686 cm 0 0 m 0 21.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 407.6887 490.7391 cm 0 0 m 321.1 0 l S Q q 1 0 0 1 407.6887 478.7391 cm 0 0 m 149.327 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn /TT1 1 Tf 11 0 0 11 407.6887 491.9046 Tm [(See Consideration for Initial Postoperative RAI Therapy )38.4 (After )]TJ ET EMC /Span <>BDC BT 11 0 0 11 407.6887 479.9046 Tm [(T)74.4 (otal Thyroidectomy \(P)74.7 (AP-5\))]TJ ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 82.9944 380.9113 cm 0 0 m 0 57.88 l S Q q 1 0 0 1 151.2539 438.7917 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT 0 0 0 scn 11 0 0 11 85.1544 429.8474 Tm (Cross)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 85.1544 417.8474 Tm (sectional )Tj ET EMC /Span <>BDC BT 11 0 0 11 85.1544 405.8474 Tm (CT or MRI )Tj ET EMC /Span <>BDC BT 11 0 0 11 85.1544 393.8474 Tm (of neck with )Tj ET EMC /Span <>BDC BT 11 0 0 11 85.1544 381.8474 Tm (contrast)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 68.9821 409.8515 cm 0 0 m 6.416 0 l S Q q 1 0 0 1 80.86 409.8515 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 133.94 165.9217 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 238.6992 235.802 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT 11 0 0 11 136.1 226.8577 Tm (For viscerally )Tj ET EMC /Span <>BDC BT -0.021 Tw 11 0 0 11 136.1 214.8577 Tm (invasive disease or )Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 136.1 202.8577 Tm (rapid progression, )Tj ET EMC /Span <>BDC BT 11 0 0 11 136.1 190.8577 Tm (upfront EBRT/)Tj ET EMC /Span <>BDC BT 11 0 0 11 136.1 178.8577 Tm (IMRT may be most )Tj ET EMC /Span <>BDC BT 11 0 0 11 136.1 166.8577 Tm (appropriate)Tj ET EMC /Span <>BDC BT 9 0 0 9 196.6107 170.8577 Tm (o)Tj ET EMC q 1 0 0 1 260.0336 153.9218 cm 0 0 m 0 93.88 l S Q q 1 0 0 1 428.3356 247.802 cm 0 0 m 0 -93.88 l S Q /Span <>BDC BT 11 0 0 11 262.1936 238.8577 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 269.1008 238.8577 Tm (TSH + Tg measurement )Tj ET EMC /Span <>BDC BT 11 0 0 11 394.7199 238.8577 Tm ( )Tj ET EMC /Span <>BDC BT -0.026 Tw 11 0 0 11 269.3936 226.8577 Tm [(+ )0.6 (antithyroglobulin )1.5 (antibodies )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 269.3936 214.8577 Tm (\(6\22612 wks postoperatively\))Tj ET EMC /Span <>BDC BT 11 0 0 11 262.1936 202.8577 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 269.1008 202.8577 Tm (Iodine)Tj /Span<>> BDC (-)Tj EMC (123 or iodine)Tj /Span<>> BDC (-)Tj EMC (131)Tj ET EMC /Span <>BDC BT 9 0 0 9 395.0207 206.8577 Tm (m )Tj ET EMC /Span <>BDC BT 11 0 0 11 269.3936 190.8577 Tm (total body radioiodine )Tj ET EMC /Span <>BDC BT 11 0 0 11 269.3936 178.8577 Tm (imaging with TSH )Tj ET EMC /Span <>BDC BT 11 0 0 11 269.3936 166.8577 Tm (stimulation \(thyroid hormone )Tj ET EMC /Span <>BDC BT 11 0 0 11 269.3936 154.8577 Tm (withdrawal)Tj ET EMC /Span <>BDC BT 9 0 0 9 326.2358 158.8577 Tm (n)Tj ET EMC /Span <>BDC BT 11 0 0 11 331.7334 154.8577 Tm (\) \(category 2B\))Tj ET EMC q 1 0 0 1 463.54 219.5079 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 526.6968 265.3882 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 11 0 0 11 465.7 256.4439 Tm (Suspected )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 244.4439 Tm (or proven )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 232.4439 Tm (inadequate )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 220.4439 Tm (RAI uptake)Tj ET EMC q 1 0 0 1 463.54 124.4269 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 525.58 194.3072 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT 11 0 0 11 465.7 185.3629 Tm (Adequate )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 173.3629 Tm (RAI uptake)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 161.3629 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 149.3629 Tm (No RAI )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 137.3629 Tm (imaging )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 125.3629 Tm (performed)Tj ET EMC q 1 0 0 1 542.7543 213.5079 cm 0 0 m 0 57.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 591.3688 213.2784 cm 0 0 m 37.7 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 544.9142 262.4439 Tm (Monitoring of )Tj ET EMC /Span <>BDC BT 11 0 0 11 544.9142 250.4439 Tm (residual disease)Tj ET EMC /Span <>BDC BT 11 0 0 11 544.9142 238.4439 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 544.9142 226.4439 Tm (Consider systemic )Tj ET EMC /Span <>BDC BT 11 0 0 11 544.9142 214.4439 Tm (therapy \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 591.3688 214.4439 Tm [(P)74.2 (AP)]TJ /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 616.8332 214.4439 Tm (10)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 629.0685 214.4439 Tm (\))Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 542.7542 118.4269 cm 0 0 m 0 81.88 l S Q /Span <>BDC BT 11 0 0 11 544.9142 191.3629 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 551.8214 191.3629 Tm (Radioiodine )Tj ET EMC /Span <>BDC BT 11 0 0 11 552.1142 179.3629 Tm (treatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 552.1142 167.3629 Tm (\(preferred\))Tj ET EMC /Span <>BDC BT 9 0 0 9 607.7372 171.3629 Tm (o)Tj ET EMC /Span <>BDC BT 11 0 0 11 544.9142 155.3629 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 551.8214 155.3629 Tm (Post-treatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 552.1142 143.3629 Tm (iodine)Tj /Span<>> BDC (-)Tj EMC (131 whole )Tj ET EMC /Span <>BDC BT 11 0 0 11 552.1142 131.3629 Tm (body imaging)Tj ET EMC /Span <>BDC BT 11 0 0 11 544.9142 119.3629 Tm <9520>Tj ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 551.8214 119.3629 Tm (TSH)Tj /Span<>> BDC (-)Tj EMC [(stimulated )0.6 (Tg)]TJ ET EMC /Artifact <>BDC 4 M q 1 0 0 1 527.349 159.3671 cm 0 0 m 9.493 0 l S Q q 1 0 0 1 542.304 159.3671 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 241.0537 200.8619 cm 0 0 m 12.178 0 l S Q q 1 0 0 1 258.6937 200.8619 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 527.349 242.4481 cm 0 0 m 9.493 0 l S Q q 1 0 0 1 542.304 242.4481 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 174.2401 335.5201 cm 0 0 m 0 -90.162 l S Q q 1 0 0 1 174.2401 239.8964 cm 0 0 m 2.552 7.012 l -2.552 7.012 l h f Q EMC /Artifact <>BDC q 1 0 0 1 211.0736 344.2431 cm 0 0 m 13.108 0 l S Q q 1 0 0 1 229.6433 344.2431 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 382.8782 348.8738 cm 0 0 m -10.447 12.437 l -0.12 24.856 l S Q q 1 0 0 1 386.3914 344.6913 cm 0 0 m -2.556 7.011 l -6.464 3.728 l h f Q q 1 0 0 1 386.2506 377.93 cm 0 0 m -6.445 -3.76 l -2.521 -7.023 l h f Q EMC /Artifact <>BDC q 1 0 0 1 455.5942 171.9936 cm 0 0 m -25.336 28.868 l -0.271 57.719 l S Q q 1 0 0 1 459.1972 167.8882 cm 0 0 m -2.708 6.954 l -6.543 3.587 l h f Q q 1 0 0 1 458.9054 233.8355 cm 0 0 m -6.525 -3.62 l -2.673 -6.967 l h f Q EMC endstream endobj 283 0 obj 22890 endobj %% Contents for page 15 %% Original object ID: 31 0 284 0 obj << /Length 285 0 R >> stream Q q BT /Xi13 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 285 0 obj 245 endobj %% Original object ID: 337 0 286 0 obj [ 2220 0 R 2221 0 R 2222 0 R 2223 0 R 2224 0 R 2225 0 R 2226 0 R 2227 0 R 2228 0 R ] endobj %% Contents for page 16 %% Original object ID: 32 0 287 0 obj << /Length 288 0 R >> stream q endstream endobj 288 0 obj 2 endobj %% Contents for page 16 %% Original object ID: 338 0 289 0 obj << /Length 290 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Papillary Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf -0.039 Tc 0.039 Tw 11 0 0 11 735.9072 23.544 Tm [(PA)-74.4 (P)-56.5 (-)-39 (5)]TJ ET EMC /Span <>BDC BT 0.035 Tc -0.058 Tw 11 0 0 11 23.7374 514.3517 Tm [(CLINICOP)74.1 (A)73.9 (THOLOGIC)17.3 ( F)55.1 (ACT)18.1 (ORS)]TJ ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 309.5934 514.3517 Tm [(CONSIDERA)73.9 (TION)17.3 ( )0.6 (FOR)17.2 ( )0.6 (INITIAL)35.7 ( )0.6 (POST)18.1 (OPERA)73.9 (TIVE)17.4 ( )0.6 (USE)17.5 ( )0.6 (OF)17.6 ( )0.6 (RAI)17.6 ( )18.2 ( )]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 653.1823 514.3517 Tm ( )Tj ET EMC /Span <>BDC BT 0.035 Tc -0.017 Tw 11 0 0 11 309.5934 502.3517 Tm [(AFTER)17.2 ( )0.6 (T)18.1 (OT)74.2 (AL)35.6 ( )0.7 (THYROIDECT)18.1 (OMY)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 270.1194 503.0067 cm 0 0 m 0 -93.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 494.0623 Tm (RAI not typically recommended \(if all present\):)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 482.0623 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 482.0623 Tm (Classic papillary thyroid carcinoma \(PTC\))Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 470.0623 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 470.0623 Tm <002f00440055004a004800560057000300530055004c005000440055005c0003005700580050005200550003001f0015000300460050>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.544 458.0623 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 458.0623 Tm (Intrathyroidal)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 446.0623 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 446.0623 Tm <00380051004c0049005200460044004f000300520055000300500058004f0057004c0049005200460044004f0003000b0044004f004f0003004900520046004c000300940014000300460050000c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.544 434.0623 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 434.0623 Tm (No detectable anti-Tg antibodies)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 422.0623 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 422.0623 Tm <0033005200560057005200530048005500440057004c0059004800030058005100560057004c00500058004f004400570048004700030037004a0003001f001400030051004a00120050002f>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 242.8458 426.0623 Tm (p)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 410.0623 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 410.0623 Tm (Negative postoperative ultrasound, if done)Tj ET EMC /Span <>BDC BT 9 0 0 9 253.5396 414.0623 Tm (q)Tj ET EMC q 1 0 0 1 274.0394 380.1946 cm 0 0 m 0 -93.88 l S Q /Span <>BDC BT 11 0 0 11 23.544 371.2503 Tm (RAI selectively recommended \(if any present\):)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 359.2503 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 359.2503 Tm (Largest primary tumor 2\2264 cm)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 347.2503 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 347.2503 Tm (High-risk histology)Tj ET EMC /Span <>BDC BT 9 0 0 9 130.0689 351.2503 Tm (r)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 335.2503 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 335.2503 Tm [(L)37.3 (ymphatic invasion )]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.544 323.2503 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 323.2503 Tm (Cervical lymph node metastases)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 311.2503 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 311.2503 Tm <003000440046005500520056004600520053004c0046000300500058004f0057004c0049005200460044004f004c0057005c0003000b005200510048000300490052004600580056000300210014000300460050000c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.544 299.2503 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 299.2503 Tm <0033005200560057005200530048005500440057004c0059004800030058005100560057004c00500058004f004400570048004700030037004a0003001f001800b10014001300030051004a00120050002f>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 261.1988 303.2503 Tm (p)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 287.2503 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 287.2503 Tm (Microscopic positive margins)Tj ET EMC q 1 0 0 1 282.96 255.7252 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT 11 0 0 11 23.544 246.7809 Tm (RAI typically recommended \(if any present\): )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 234.7809 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 234.7809 Tm (Gross extrathyroidal extension)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 222.7809 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 222.7809 Tm <00330055004c005000440055005c000300570058005000520055000300210017000300460050>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.544 210.7809 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 210.7809 Tm <0033005200560057005200530048005500440057004c0059004800030058005100560057004c00500058004f004400570048004700030037004a00030021001800b10014001300030051004a00120050002f>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 261.1988 214.7809 Tm (p,s)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 198.7809 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 198.7809 Tm <00250058004f004e005c0003005200550003002100180003005300520056004c0057004c005900480003004f005c00500053004b000300510052004700480056>Tj ET EMC q 1 0 0 1 583 423.0319 cm 0 0 m 0 -81.88 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 309.4 414.0876 Tm (RAI ablation is not required in patients with classic )Tj ET EMC /Span <>BDC BT 11 0 0 11 309.4 402.0876 Tm (PTC who have T1b/T2 \(1\2264 cm\) N0a and/or N0b )Tj ET EMC /Span <>BDC BT 11 0 0 11 309.4 390.0876 Tm (disease or small-volume N1a disease \(fewer than )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 309.4 378.0876 Tm <0018000300500048005700440056005700440057004c00460003004f005c00500053004b0003005100520047004800560003005a004c0057004b0003001f00150003005000500003005200490003004900520046005800560003005200490003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 309.4 366.0876 Tm (cancer in node\), particularly if the postoperative )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 309.4 354.0876 Tm [<0037004a0003004c00560003001f001400030051004a00120050002f>19.3 <0003004c005100030057004b0048000300440045005600480051004600480003005200490003004c0051005700480055004900480055004c0051004a0003004400510057004c>]TJ /Span<>> BDC <0010>Tj EMC <0037004a0003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 309.4 342.0876 Tm (antibodies. )Tj ET EMC q 1 0 0 1 583 326.0536 cm 0 0 m 0 -81.88 l S Q /Span <>BDC BT 11 0 0 11 309.4 317.1093 Tm (RAI ablation is recommended when the )Tj ET EMC /Span <>BDC BT 11 0 0 11 309.4 305.1093 Tm (combination of individual clinical factors \(such as )Tj ET EMC /Span <>BDC BT 11 0 0 11 309.4 293.1093 Tm [(the size of the primary tumor)55.6 (, histology)75.2 (, degree )]TJ ET EMC /Span <>BDC BT 11 0 0 11 309.4 281.1093 Tm (of lymphatic invasion, lymph node metastases, )Tj ET EMC /Span <>BDC BT 11 0 0 11 309.4 269.1093 Tm (postoperative thyroglobulin, and age at diagnosis\) )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 309.4 257.1093 Tm <0053005500480047004c0046005700560003004400030056004c004a0051004c00bf004600440051005700030055004c0056004e00030052004900030055004800460058005500550048005100460048000f00030047004c005600570044005100570003>Tj ET EMC /Span <>BDC BT 11 0 0 11 309.4 245.1093 Tm <0050004800570044005600570044005600480056000f00030052005500030047004c00560048004400560048>Tj /Span<>> BDC <0010>Tj EMC [<0056005300480046004c00bf0046000300500052005500570044004f004c0057005c>72.9 <0011>]TJ ET EMC /Artifact <>BDC 4 M q 1 0 0 1 306.36 422 cm 0 0 m 0 -177.491 l S Q EMC /Artifact <>BDC q 1 0 0 1 274.72 333.2545 cm 0 0 m 24.378 0 l S Q q 1 0 0 1 304.56 333.2545 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 633.7495 406.3657 cm 0 0 m 54.21 0 l S Q /Span <>BDC BT /GS0 gs /TT1 1 Tf 11 0 0 11 633.7495 431.5312 Tm (RAI not typically )Tj ET EMC /Span <>BDC BT 11 0 0 11 633.7495 419.5312 Tm (indicated, )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 633.7495 407.5312 Tm [(See P)74.1 (AP-)]TJ ET EMC /Span <>BDC BT 11 0 0 11 681.8423 407.5312 Tm (8)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS0 gs q 1 0 0 1 285.12 226.785 cm 0 0 m 334.098 0 l S Q 0 0 0 scn q 1 0 0 1 624.6801 226.785 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 633.7495 243.8303 cm 0 0 m 54.21 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 633.7495 268.9958 Tm (RAI being )Tj ET EMC /Span <>BDC BT 11 0 0 11 633.7495 256.9958 Tm (considered, )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 633.7495 244.9958 Tm [(See P)74.1 (AP-)]TJ ET EMC /Span <>BDC BT 11 0 0 11 681.8423 244.9958 Tm (6)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 23.544 183.1127 Tm (Known or suspected distant metastases at presentation)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 325.1157 187.1169 cm 0 0 m 294.102 0 l S Q q 1 0 0 1 624.6801 187.1169 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 630.78 306 cm 0 0 m 0 -90 l S Q EMC /Span <>BDC BT 11 0 0 11 23.544 156.9395 Tm (Gross residual disease not amenable to RAI therapy)Tj ET EMC /Artifact <>BDC q 1 0 0 1 299.52 160.9436 cm 0 0 m 319.698 0 l S Q q 1 0 0 1 624.6801 160.9436 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 633.7495 155.7739 cm 0 0 m 60.328 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 633.7495 156.9395 Tm [(See P)74.1 (AP-)]TJ ET EMC /Span <>BDC BT 11 0 0 11 681.8423 156.9395 Tm (10)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 8 0 0 8 23.7612 133.456 Tm (p)Tj ET EMC /Span <>BDC BT /Span<>> BDC 8 0 0 8 28.2104 133.456 Tm ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 130.456 Tm [(Tg values obtained 6\22612 we)-1.2 (eks after total thyroidectomy)74 (.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 122.456 Tm (q)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 119.456 Tm [(If preoperative imaging inco)-1.3 (mplete, consider postoperativ)-1.5 (e ultrasound including central and lateral neck components.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 111.456 Tm (r)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 108.456 Tm [(ie, poorly dif)17.9 (ferentiated, tall cell, columnar cell, and hobna)-1.8 (il variants.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 100.456 Tm (s)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm [(Additio)-0.6 (nal cross-sectional im)-0.8 (aging \(CT)17.6 ( or MRI of the neck with contrast and chest CT)17.7 ( with contrast\) should be )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 86.456 Tm (considered to rule out the presence of significant normal thyroid remnant or gross residual disease and to detect ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 75.456 Tm (clinically significant distant metastases.)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 586.3632 382.0919 cm 0 0 m 32.855 0 l S Q q 1 0 0 1 624.6801 382.0919 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 630.78 478.0707 cm 0 0 m 0 -109.071 l S Q EMC /Artifact <>BDC q 1 0 0 1 586.3632 285.1135 cm 0 0 m 32.855 0 l S Q q 1 0 0 1 624.6801 285.1135 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 600.6853 94.6824 cm 0 0 m 144.853 0 l S Q q 1 0 0 1 559.72 82.6824 cm 0 0 m 194.971 0 l S Q /Span <>BDC BT /GS0 gs /TT1 1 Tf 11 0 0 11 559.72 119.848 Tm (For general principles related to )Tj ET EMC /Span <>BDC BT 11 0 0 11 559.72 107.848 Tm [(radioactive iodine \(RAI\) therapy)74.6 (, )]TJ ET EMC /Span <>BDC BT 11 0 0 11 559.72 95.848 Tm (see the )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 600.6853 95.848 Tm (Principles of Radiation and )Tj ET EMC /Span <>BDC BT 11 0 0 11 559.72 83.848 Tm (Radioactive Iodine Therapy \(THYR)Tj /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 754.6907 83.848 Tm (.)Tj ET EMC 0 0 0 SCN 1 w 4 M 556.34 80.468 211.616 50.768 re S /Artifact <>BDC q 1 0 0 1 274.72 456.0665 cm 0 0 m 344.498 0 l S Q q 1 0 0 1 624.6801 456.0665 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 633.7495 175.9472 cm 0 0 m 54.21 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 633.7495 189.1127 Tm (Amenable to RAI)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 633.7495 177.1127 Tm [(See P)74.1 (AP-)]TJ ET EMC /Span <>BDC BT 11 0 0 11 681.8422 177.1127 Tm (7)Tj ET EMC endstream endobj 290 0 obj 17487 endobj %% Contents for page 16 %% Original object ID: 33 0 291 0 obj << /Length 292 0 R >> stream Q q BT /Xi14 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 292 0 obj 245 endobj %% Original object ID: 340 0 293 0 obj [ 2229 0 R 2230 0 R 2231 0 R 2232 0 R 2233 0 R 2234 0 R 2235 0 R 2236 0 R 2237 0 R 2238 0 R 2239 0 R ] endobj %% Contents for page 17 %% Original object ID: 34 0 294 0 obj << /Length 295 0 R >> stream q endstream endobj 295 0 obj 2 endobj %% Contents for page 17 %% Original object ID: 341 0 296 0 obj << /Length 297 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Papillary Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf -0.039 Tc 0.039 Tw 11 0 0 11 735.9072 23.544 Tm [(PA)-74.4 (P)-56.5 (-)-39 (6)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 119.3846 325.6217 cm 0 0 m 0 93.88 l S Q q 1 0 0 1 226.66 419.502 cm 0 0 m 0 -93.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 121.5446 325.3922 cm 0 0 m 61.537 0 l S Q /Span <>BDC BT /GS0 gs 0 Tc 0 Tw 11 0 0 11 121.5446 410.5577 Tm (Clinicopathologic )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 121.5446 398.5577 Tm <00bf00510047004c0051004a00560003005300550052005000530057004c0051004a0003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 121.5446 386.5577 Tm (consideration for )Tj ET EMC /Span <>BDC BT 11 0 0 11 121.5446 374.5577 Tm (RAI, without gross )Tj ET EMC /Span <>BDC BT 11 0 0 11 121.5446 362.5577 Tm (residual disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 121.5446 350.5577 Tm (or known distant )Tj ET EMC /Span <>BDC BT 11 0 0 11 121.5446 338.5577 Tm (metastasis)Tj ET EMC /Span <>BDC BT 11 0 0 11 178.4138 338.5577 Tm ( )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 121.5446 326.5577 Tm (\()Tj ET EMC /Span <>BDC BT 11 0 0 11 125.2077 326.5577 Tm [(See P)74.1 (AP-)]TJ ET EMC /Span <>BDC BT 11 0 0 11 173.3005 326.5577 Tm (5\))Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 334.48 380.081 cm 0 0 m 0 81.88 l S Q q 1 0 0 1 429.7633 461.9613 cm 0 0 m 0 -81.88 l S Q /Span <>BDC BT 0 0 0 scn 11 0 0 11 336.64 453.017 Tm (Consider )Tj ET EMC /Span <>BDC BT 11 0 0 11 336.64 441.017 Tm (pretreatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 336.64 429.017 Tm (iodine)Tj /Span<>> BDC (-)Tj EMC (123 whole )Tj ET EMC /Span <>BDC BT 11 0 0 11 336.64 417.017 Tm (body diagnostic )Tj ET EMC /Span <>BDC BT 11 0 0 11 336.64 405.017 Tm (imaging)Tj ET EMC /Span <>BDC BT 9 0 0 9 378.8085 409.017 Tm (t,u)Tj ET EMC /Span <>BDC BT 11 0 0 11 389.8036 405.017 Tm ( with )Tj ET EMC /Span <>BDC BT 11 0 0 11 336.64 393.017 Tm (TSH stimulation)Tj ET EMC /Span <>BDC BT 9 0 0 9 420.3646 397.017 Tm (o)Tj ET EMC /Span <>BDC BT 11 0 0 11 336.64 381.017 Tm (\(category 2B\))Tj ET EMC /Span <>BDC BT -0.074 Tc 0.074 Tw 9 0 0 9 406.9369 385.017 Tm [(v,)-73.9 (w)]TJ ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 312.999 421.0212 cm 0 0 m 15.178 0 l S Q q 1 0 0 1 333.639 421.0212 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M q 1 0 0 1 677.88 377.1907 cm 0 0 m 38.908 0 l S Q q 1 0 0 1 736.5538 341.1907 cm 0 0 m 26.292 0 l S Q q 1 0 0 1 677.88 329.1907 cm 0 0 m 45.214 0 l S Q /Span <>BDC BT /GS0 gs 0 Tc 0 Tw 11 0 0 11 670.68 414.3562 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 677.5872 414.3562 Tm (See Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 677.88 402.3562 Tm (Monitoring and )Tj ET EMC /Span <>BDC BT 11 0 0 11 677.88 390.3562 Tm (Maintenance )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 677.88 378.3562 Tm [(\(P)74.2 (AP-8\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 670.68 366.3562 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 677.5872 366.3562 Tm (Levothyroxine )Tj ET EMC /Span <>BDC BT 11 0 0 11 677.88 354.3562 Tm (to appropriate )Tj ET EMC /Span <>BDC BT 11 0 0 11 677.88 342.3562 Tm (TSH target )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 736.5538 342.3562 Tm (\()Tj ET EMC /Span <>BDC BT 11 0 0 11 740.2169 342.3562 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 677.88 330.3562 Tm (THYR-A\))Tj ET EMC q 1 0 0 1 29.5212 162.3964 cm 0 0 m 245.474 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 8 0 0 8 23.7612 166.456 Tm (o)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 163.456 Tm (See )Tj ET EMC /Span <>BDC BT 10 0 0 10 50.0925 163.456 Tm [(Principle)-0.8 (s of Radiation )-0.7 (and RAI )18.1 (Therapy \(THYR)]TJ /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 274.9949 163.456 Tm (.)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 8 0 0 8 23.7612 155.456 Tm <0d9c>Tj ET EMC /Span <>BDC BT /TT0 1 Tf /Span<>> BDC 8 0 0 8 27.6792 155.456 Tm ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 152.456 Tm (Even in the absence of thyroid bed uptake RAI treatment m)Tj (ay be considered. If higher than expected uptake \(residual thyroid uptake or distant metastasis\) change ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 141.456 Tm [(dose accordingly)72.8 (.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 133.456 Tm (u)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 130.456 Tm [(A)55.2 ( false)]TJ /Span<>> BDC (-)Tj EMC [(negative pretreatment scan is possible and should)-1.8 ( not prevent the use of RAI if otherwise indicated.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 122.456 Tm (v)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 119.456 Tm [(Alternatively)73.7 (, low-dose iodin)-1.3 (e)]TJ /Span<>> BDC (-)Tj EMC [(131 \(1\2263 mCi\) may be used)-1.4 (. )]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 111.456 Tm (w )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 31.7612 108.456 Tm (While pre-ablation diagnostic scans in this setting are commonly done at NCCN Member Institutions, the panel recommends \(category 2B\) selective use of ) Tj ET EMC /Span <>BDC BT 10 0 0 10 31.7612 97.456 Tm [(pre-ablation diagnostic scans based on pathology)70.8 (, postoperative )17.6 (Tg, intraoperative findings, and available imaging studies. Furthermore, dosimetry studies are ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 31.7612 86.456 Tm (considered in patients at high risk of having RAI-avid distant metastasis. Empiric RAI doses may exceed maximum tolerable activity levels in patients with decreased ) Tj ET EMC /Span <>BDC BT 10 0 0 10 31.7612 75.456 Tm (glomerular filtration rate \(GFR\). Dialysis patients require special handling.) Tj ET EMC /Span <>BDC BT /TT1 1 Tf 0.035 Tc -0.017 Tw 11 0 0 11 23.7374 514.0935 Tm [(RAI)17.5 ( )0.7 (BEING)17.6 ( )0.6 (CONSIDERED)17.2 ( )0.6 (BASED)17.3 ( )0.6 (ON)17.2 ( )0.6 (CLINICOP)74.1 (A)73.9 (THOLOGIC)17.2 ( )0.6 (FEA)73.9 (TURES)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 101.5509 389.502 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.4333 380.5577 Tm (6\22612 weeks )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.4333 368.5577 Tm (post)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 23.4333 356.5577 Tm (thyroidectomy)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 103.36 372.5618 cm 0 0 m 7.378 0 l S Q q 1 0 0 1 116.2 372.5618 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 450.3227 392.081 cm 0 0 m 0 57.88 l S Q q 1 0 0 1 543.2346 449.9613 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT 11 0 0 11 452.4827 441.017 Tm (Resect clinically )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 452.4827 429.017 Tm <0056004c004a0051004c00bf00460044005100570003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 452.4827 417.017 Tm (structural )Tj ET EMC /Span <>BDC BT 11 0 0 11 452.4827 405.017 Tm (disease if )Tj ET EMC /Span <>BDC BT 11 0 0 11 452.4827 393.017 Tm (possible )Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 430.6043 421.0212 cm 0 0 m 13.08 0 l S Q q 1 0 0 1 449.1468 421.0212 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 545 421.0212 cm 0 0 m 8.978 0 l S Q q 1 0 0 1 559.44 421.0212 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 242.84 398.081 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 308.9202 443.9613 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 11 0 0 11 245 435.017 Tm (RAI therapy )Tj ET EMC /Span <>BDC BT 11 0 0 11 245 423.017 Tm (indicated )Tj ET EMC /Span <>BDC BT 11 0 0 11 245 411.017 Tm (based on )Tj ET EMC /Span <>BDC BT 11 0 0 11 245 399.017 Tm (pathology)Tj ET EMC q 1 0 0 1 242.84 309.0901 cm 0 0 m 0 33.88 l S Q q 1 0 0 1 335.799 342.9704 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 11 0 0 11 245 334.0261 Tm (RAI therapy not )Tj ET EMC /Span <>BDC BT 11 0 0 11 245 322.0261 Tm (indicated based )Tj ET EMC /Span <>BDC BT 11 0 0 11 245 310.0261 Tm (on pathology)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 339.1779 326.0303 cm 0 0 m 323.938 0 l S Q q 1 0 0 1 668.5779 326.0303 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC /GS0 gs q 1 0 0 1 240.1519 351.6891 cm 0 0 m -13.673 20.873 l -0.147 41.732 l S Q q 1 0 0 1 243.145 347.1201 cm 0 0 m -1.708 7.264 l -5.977 4.467 l h f Q q 1 0 0 1 242.9769 398.0038 cm 0 0 m -5.956 -4.495 l -1.674 -7.272 l h f Q EMC 10 M q 1 0 0 1 562.32 362.081 cm 0 0 m 0 117.88 l S Q q 1 0 0 1 651.1309 479.9613 cm 0 0 m 0 -117.88 l S Q /Span <>BDC BT 11 0 0 11 564.48 471.017 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 571.3872 471.017 Tm (RAI therapy )Tj ET EMC /Span <>BDC BT 11 0 0 11 571.68 459.017 Tm (for remnant )Tj ET EMC /Span <>BDC BT 11 0 0 11 571.68 447.017 Tm (ablation or )Tj ET EMC /Span <>BDC BT 11 0 0 11 571.68 435.017 Tm (adjuvant )Tj ET EMC /Span <>BDC BT 11 0 0 11 571.68 423.017 Tm (therapy)Tj ET EMC /Span <>BDC BT 9 0 0 9 611.4153 427.017 Tm (o)Tj ET EMC /Span <>BDC BT 11 0 0 11 564.48 411.017 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 571.3872 411.017 Tm (Post)Tj /Span<>> BDC (-)Tj EMC (treatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 571.68 399.017 Tm (iodine)Tj /Span<>> BDC (-)Tj EMC (131 )Tj ET EMC /Span <>BDC BT 11 0 0 11 571.68 387.017 Tm (imaging )Tj ET EMC /Span <>BDC BT 11 0 0 11 571.68 375.017 Tm (\(whole body )Tj ET EMC /Span <>BDC BT 11 0 0 11 571.68 363.017 Tm (RAI scan\))Tj ET EMC /Span <>BDC BT 9 0 0 9 622.4153 367.017 Tm (o)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 652.32 424.0212 cm 0 0 m 10.796 0 l S Q q 1 0 0 1 668.5779 424.0212 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 669.54 436.0732 cm 0 0 m 0 -119.426 l S Q EMC endstream endobj 297 0 obj 14293 endobj %% Contents for page 17 %% Original object ID: 35 0 298 0 obj << /Length 299 0 R >> stream Q q BT /Xi15 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 299 0 obj 245 endobj %% Original object ID: 343 0 300 0 obj [ 2240 0 R 2241 0 R 2242 0 R 2243 0 R 2244 0 R 2245 0 R 2246 0 R 2247 0 R 2248 0 R 2249 0 R 2250 0 R ] endobj %% Contents for page 18 %% Original object ID: 36 0 301 0 obj << /Length 302 0 R >> stream q endstream endobj 302 0 obj 2 endobj %% Contents for page 18 %% Original object ID: 344 0 303 0 obj << /Length 304 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Papillary Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf -0.039 Tc 0.039 Tw 11 0 0 11 735.9072 23.544 Tm [(PA)-74.4 (P)-56.5 (-)-39 (7)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 119.2211 318.6229 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 195.9674 388.5032 cm 0 0 m 0 -69.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 121.3811 318.3934 cm 0 0 m 61.537 0 l S Q /Span <>BDC BT /GS0 gs 0 Tc 0 Tw 11 0 0 11 121.3811 379.5589 Tm (Known or )Tj ET EMC /Span <>BDC BT 11 0 0 11 121.3811 367.5589 Tm (suspected )Tj ET EMC /Span <>BDC BT 11 0 0 11 121.3811 355.5589 Tm (distant )Tj ET EMC /Span <>BDC BT -0.031 Tw 11 0 0 11 121.3811 343.5589 Tm [(metastases )-1.1 (at )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 121.3811 331.5589 Tm (presentation)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 121.3811 319.5589 Tm (\()Tj ET EMC /Span <>BDC BT 11 0 0 11 125.0442 319.5589 Tm [(See P)74.1 (AP-)]TJ ET EMC /Span <>BDC BT 11 0 0 11 173.137 319.5589 Tm (5\))Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 105.12 370.5033 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 0 0 0 scn 11 0 0 11 24.5446 361.559 Tm (6\22612 weeks )Tj ET EMC /Span <>BDC BT 11 0 0 11 24.5446 349.559 Tm (post)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 24.5446 337.559 Tm (thyroidectomy)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 195.818 353.563 cm 0 0 m 9.138 0 l S Q q 1 0 0 1 210.418 353.563 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 210.2685 282.623 cm 0 0 m 0 141.88 l S Q q 1 0 0 1 310.6086 424.5033 cm 0 0 m 0 -141.88 l S Q /Span <>BDC BT 11 0 0 11 212.4285 415.559 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 219.3358 415.559 Tm (Appropriate )Tj ET EMC /Span <>BDC BT 11 0 0 11 219.6285 403.559 Tm (cross-sectional )Tj ET EMC /Span <>BDC BT 11 0 0 11 219.6285 391.559 Tm (imaging \(CT )Tj ET EMC /Span <>BDC BT 11 0 0 11 219.6285 379.559 Tm (or MRI with )Tj ET EMC /Span <>BDC BT 11 0 0 11 219.6285 367.559 Tm (contrast\) )Tj ET EMC /Span <>BDC BT 11 0 0 11 219.6285 355.559 Tm (of known )Tj ET EMC /Span <>BDC BT 11 0 0 11 219.6285 343.559 Tm (metastatic foci)Tj ET EMC /Span <>BDC BT 9 0 0 9 296.6554 347.559 Tm (x)Tj ET EMC /Span <>BDC BT 11 0 0 11 212.4285 331.559 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 219.3358 331.559 Tm (Resect clinically )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 219.6285 319.559 Tm <0056004c004a0051004c00bf00460044005100570003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 219.6285 307.559 Tm (structural )Tj ET EMC /Span <>BDC BT 11 0 0 11 219.6285 295.559 Tm (disease if )Tj ET EMC /Span <>BDC BT 11 0 0 11 219.6285 283.559 Tm (possible)Tj ET EMC q 1 0 0 1 324.9097 282.623 cm 0 0 m 0 141.88 l S Q q 1 0 0 1 436.1281 424.5033 cm 0 0 m 0 -141.88 l S Q /Span <>BDC BT 11 0 0 11 327.0697 415.559 Tm (6 weeks following )Tj ET EMC /Span <>BDC BT 11 0 0 11 327.0697 403.559 Tm (cross)Tj /Span<>> BDC (-)Tj EMC (sectional )Tj ET EMC /Span <>BDC BT 11 0 0 11 327.0697 391.559 Tm (imaging:)Tj ET EMC /Span <>BDC BT 11 0 0 11 327.0697 379.559 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 333.9769 379.559 Tm (Consider 24)Tj /Span<>> BDC (-)Tj EMC (hour )Tj ET EMC /Span <>BDC BT 11 0 0 11 334.2697 367.559 Tm (urine iodine)Tj ET EMC /Span <>BDC BT 11 0 0 11 327.0697 355.559 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 333.9769 355.559 Tm (Pretreatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 334.2697 343.559 Tm (radioiodine )Tj ET EMC /Span <>BDC BT -0.048 Tw 11 0 0 11 334.2697 331.559 Tm [(diagnostic )1 (imaging )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 334.2697 319.559 Tm (\(iodine)Tj /Span<>> BDC (-)Tj EMC (123 or )Tj ET EMC /Span <>BDC BT 11 0 0 11 334.2697 307.559 Tm (iodine)Tj /Span<>> BDC (-)Tj EMC (131\) )Tj ET EMC /Span <>BDC BT 11 0 0 11 334.2697 295.559 Tm (with TSH )Tj ET EMC /Span <>BDC BT 11 0 0 11 334.2697 283.559 Tm (stimulation)Tj ET EMC /Span <>BDC BT 9 0 0 9 392.9381 287.559 Tm [(o,w)37.6 (,y)]TJ ET EMC q 1 0 0 1 457.1188 389.4099 cm 0 0 m 0 81.88 l S Q q 1 0 0 1 525.4 471.2902 cm 0 0 m 0 -81.88 l S Q /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 459.2788 462.3459 Tm <00260052005100bf00550050004800470003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 459.2788 450.3459 Tm (radioiodine)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 459.2788 438.3459 Tm (avid tumor)Tj ET EMC /Span <>BDC BT 11 0 0 11 459.2788 426.3459 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 459.2788 414.3459 Tm (Thyroid )Tj ET EMC /Span <>BDC BT 11 0 0 11 459.2788 402.3459 Tm (remnant )Tj ET EMC /Span <>BDC BT 11 0 0 11 459.2788 390.3459 Tm (uptake only)Tj ET EMC q 1 0 0 1 550.1188 407.4099 cm 0 0 m 0 45.88 l S Q /Span <>BDC BT 11 0 0 11 552.2788 444.3459 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 559.186 444.3459 Tm (RAI therapy )Tj ET EMC /Span <>BDC BT 11 0 0 11 552.2788 432.3459 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 559.186 432.3459 Tm (Post-treatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 559.4788 420.3459 Tm (imaging \(whole )Tj ET EMC /Span <>BDC BT 11 0 0 11 559.4788 408.3459 Tm (body RAI scan\))Tj ET EMC /Span <>BDC BT 11 0 0 11 459.2788 298.772 Tm (No uptake)Tj ET EMC q 1 0 0 1 550.1188 279.836 cm 0 0 m 0 57.88 l S Q /Span <>BDC BT 11 0 0 11 552.2788 328.772 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 559.186 328.772 Tm (Consider RAI )Tj ET EMC /Span <>BDC BT 11 0 0 11 559.4788 316.772 Tm (adjuvant therapy)Tj ET EMC /Span <>BDC BT 11 0 0 11 552.2788 304.772 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 559.186 304.772 Tm (Post-treatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 559.4788 292.772 Tm (imaging \(whole )Tj ET EMC /Span <>BDC BT 11 0 0 11 559.4788 280.772 Tm (body RAI scan\))Tj ET EMC q 1 0 0 1 669.84 322.123 cm 0 0 m 0 93.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 679.2 369.8934 cm 0 0 m 38.908 0 l S Q q 1 0 0 1 737.8738 333.8934 cm 0 0 m 26.292 0 l S Q q 1 0 0 1 679.2 321.8934 cm 0 0 m 45.214 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 672 407.059 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 678.9072 407.059 Tm (See Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 679.2 395.059 Tm (Monitoring and )Tj ET EMC /Span <>BDC BT 11 0 0 11 679.2 383.059 Tm (Maintenance )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 679.2 371.059 Tm [(\(P)74.2 (AP-8\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 672 359.059 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 678.9072 359.059 Tm (Levothyroxine )Tj ET EMC /Span <>BDC BT 11 0 0 11 679.2 347.059 Tm (to appropriate )Tj ET EMC /Span <>BDC BT 11 0 0 11 679.2 335.059 Tm (TSH target )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 737.8738 335.059 Tm (\()Tj ET EMC /Span <>BDC BT 11 0 0 11 741.5369 335.059 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 679.2 323.059 Tm (THYR-A\))Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 310.4591 353.563 cm 0 0 m 9.138 0 l S Q 0 0 0 scn q 1 0 0 1 325.0591 353.563 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 452.9839 317.2235 cm 0 0 m -14.765 36.34 l -0.152 72.672 l S Q q 1 0 0 1 455.04 312.1631 cm 0 0 m -0.275 7.457 l -5.004 5.536 l h f Q q 1 0 0 1 454.8704 394.9631 cm 0 0 m -4.984 -5.554 l -0.249 -7.458 l h f Q EMC /Artifact <>BDC q 1 0 0 1 525.9 430.35 cm 0 0 m 15.438 0 l S Q q 1 0 0 1 546.8 430.35 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 517 302.7762 cm 0 0 m 24.338 0 l S Q q 1 0 0 1 546.8 302.7762 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 104.9706 353.563 cm 0 0 m 8.938 0 l S Q q 1 0 0 1 119.3706 353.563 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 652.7787 457.3541 cm 0 0 m 0 -176.582 l S Q EMC /Artifact <>BDC /GS0 gs q 1 0 0 1 653.8076 369.063 cm 0 0 m 8.73 0 l S Q q 1 0 0 1 667.9994 369.063 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 0.035 Tc -0.023 Tw 11 0 0 11 23.7373 514.3517 Tm [(KNOWN)17.2 ( OR)17.3 ( SUSPECTED)17.2 ( DIST)74.2 (ANT)17.6 ( MET)74.2 (AST)74.2 (A)73.9 (TIC)17.2 ( DISEASE)]TJ ET EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 29.5212 151.3964 cm 0 0 m 245.474 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 0 Tc 0 Tw 8 0 0 8 23.7612 155.456 Tm (o)Tj ET EMC /Span <>BDC BT /Span<>> BDC 8 0 0 8 28.2104 155.456 Tm ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 152.456 Tm (See )Tj ET EMC /Span <>BDC BT 10 0 0 10 50.0925 152.456 Tm [(Principl)-0.8 (es of Radiation )-0.7 (and RAI )18.4 (Therapy \(THYR)]TJ /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 274.9948 152.456 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 144.456 Tm (w )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 31.7612 141.456 Tm (While pre-ablation diagnostic scans in this setting are commonly done at NCCN Member Institutions, the panel recommends \(category 2B\) selective use of ) Tj ET EMC /Span <>BDC BT 10 0 0 10 31.7612 130.456 Tm [(pre-ablation diagnostic scans based on pathology)70.8 (, postoperative )17.6 (Tg, intraoperative finds, and available imaging studies. Furthermore, dosimetry studies are ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 31.7612 119.456 Tm (considered in patients at high risk of having RAI-avid distant metastasis. Empiric RAI doses may exceed maximum tolerable activity levels in patients with decreased ) Tj ET EMC /Span <>BDC BT 10 0 0 10 31.7612 108.456 Tm (GFR. Dialysis patients require special handling.)Tj ET EMC /Span <>BDC BT -0.058 Tw 8 0 0 8 23.7612 100.456 Tm (x)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 Tw 10 0 0 10 29.5212 97.456 Tm [(T)111 (o evaluate macroscopic me)-0.7 (tastatic foci for potential alte)-0.7 (rative therapies \(eg, surgical resection, external beam irradiation\) to prevent invasion/compression of vital ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 86.456 Tm [(structures or pathologic fracture either as a result of disease progression or ) 15.5 (TSH stimulation.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 78.456 Tm (y)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 75.456 Tm [(Thyrotropin alfa may be used for elderly patients for when)-1 ( prolonged hypothyroidism may be risky)71.9 (.)]TJ ET EMC endstream endobj 304 0 obj 14985 endobj %% Contents for page 18 %% Original object ID: 37 0 305 0 obj << /Length 306 0 R >> stream Q q BT /Xi16 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 306 0 obj 245 endobj %% Original object ID: 346 0 307 0 obj [ 2251 0 R 2252 0 R 2253 0 R 2254 0 R 2255 0 R 2256 0 R 2257 0 R ] endobj %% Contents for page 19 %% Original object ID: 38 0 308 0 obj << /Length 309 0 R >> stream q endstream endobj 309 0 obj 2 endobj %% Contents for page 19 %% Original object ID: 347 0 310 0 obj << /Length 311 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Papillary Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf -0.039 Tc 0.039 Tw 11 0 0 11 735.9164 23.544 Tm [(PA)-74.1 (P)-56.4 (-)-38.8 (8)]TJ ET EMC /Span <>BDC BT 0.035 Tc -0.054 Tw 11 0 0 11 23.738 514.3517 Tm [(DISEASE)17.5 ( )-36.4 (MONIT)18.1 (ORING)17.6 ( )0.7 (AND)17.3 ( )]TJ ET EMC /Span <>BDC BT -0.035 Tw 11 0 0 11 23.738 502.3517 Tm (MAINTENANCE)Tj ET EMC /GS1 gs q 1 0 0 1 34.8823 74.3964 cm 0 0 m 171.733 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 0 Tc 0 Tw 8 0 0 8 23.7612 111.456 Tm (z)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 108.456 Tm [(A)55.2 ( subgroup of low-risk patie)-1 (nts may only require an ultras)-1.1 (ound if there is a reasonable suspicion for recurrence. )]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 100.456 Tm (aa )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 34.8823 97.456 Tm [(In selected patients who may be at higher risk for residual/recurrent disease \(eg, N1 patients\), obtain a stimulated ) 14 (Tg and consider concomitant diagnostic RAI )]TJ ET EMC /Span <>BDC BT 10 0 0 10 34.8823 86.456 Tm (imaging. )Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 78.456 Tm (bb )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 34.8823 75.456 Tm (See NCCN Guidelines for Survivorship)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 206.6157 75.456 Tm (.)Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 285.0803 458.376 cm 0 0 m 0 -189.88 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.5446 449.4317 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4518 449.4317 Tm (Physical examination, TSH and Tg )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 437.4317 Tm (measurement + antithyroglobulin antibodies at )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 425.4317 Tm (6 and 12 mo, then annually if disease-free)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.5446 413.4317 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4518 413.4317 Tm (Periodic neck ultrasound)Tj ET EMC /Span <>BDC BT 9 0 0 9 161.8717 417.4317 Tm (z)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.5446 401.4317 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4518 401.4317 Tm (Consider TSH-stimulated or TSH-unstimulated )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 389.4317 Tm (Tg measurements using an ultrasensitive )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 377.4317 Tm (assay in patients previously treated with RAI )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 365.4317 Tm (and with negative TSH-suppressed Tg and )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 353.4317 Tm (anti-thyroglobulin antibodies)Tj ET EMC /Span <>BDC BT 9 0 0 9 182.29 357.4317 Tm (aa)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.5446 341.4317 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4518 341.4317 Tm (Consider TSH-stimulated radioiodine whole )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 329.4317 Tm (body imaging in high-risk patients, patients )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 317.4317 Tm (with previous RAI-avid metastases, or )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 305.4317 Tm (patients with abnormal Tg levels \(either )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 293.4317 Tm (TSH-suppressed or TSH-stimulated\), stable or )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 281.4317 Tm (rising antithyroglobulin antibodies, or abnormal )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 269.4317 Tm (ultrasound during surveillance)Tj ET EMC /Span <>BDC BT 0.034 Tc -0.034 Tw 11 0 0 11 395.5031 514.3517 Tm (MANAGEMENT)Tj ET EMC q 1 0 0 1 312.0769 421.7457 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 371.963 467.626 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 314.2369 458.6817 Tm (No )Tj ET EMC /Span <>BDC BT 11 0 0 11 314.2369 446.6817 Tm (evidence )Tj ET EMC /Span <>BDC BT 11 0 0 11 314.2369 434.6817 Tm (of disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 314.2369 422.6817 Tm (\(NED\))Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 372.96 444.6859 cm 0 0 m 11.326 0 l S Q q 1 0 0 1 389.7484 444.6859 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 393.1497 385.7457 cm 0 0 m 0 117.88 l S Q q 1 0 0 1 674.7316 503.626 cm 0 0 m 0 -117.88 l S Q 0.75 w q 1 0 0 1 395.3097 493.5162 cm 0 0 m 158.292 0 l S Q /Span <>BDC BT 11 0 0 11 395.3097 494.6817 Tm (Long-term disease monitoring)Tj ET EMC /Span <>BDC BT 9 0 0 9 553.6012 498.6817 Tm (bb)Tj ET EMC /Span <>BDC BT 11 0 0 11 395.3097 482.6817 Tm (Patients treated with iodine)Tj /Span<>> BDC (-)Tj EMC (131 ablation, with )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 395.3097 470.6817 Tm [<0044000300510048004a00440057004c0059004800030058004f00570055004400560052005800510047000f000300560057004c00500058004f004400570048004700030037004a0003001f001500030051004a00120050002f>20.1 <0003>]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 395.3097 458.6817 Tm (\(with negative antithyroglobulin antibodies\), and )Tj ET EMC /Span <>BDC BT 11 0 0 11 395.3097 446.6817 Tm (negative RAI imaging \(if performed\) may be followed )Tj ET EMC /Span <>BDC BT 11 0 0 11 395.3097 434.6817 Tm (by unstimulated thyroglobulin annually and by )Tj ET EMC /Span <>BDC BT 11 0 0 11 395.3097 422.6817 Tm (periodic neck ultrasound. TSH-stimulated testing, )Tj ET EMC /Span <>BDC BT 11 0 0 11 395.3097 410.6817 Tm (or other imaging \(eg, CT or MRI with contrast\) as )Tj ET EMC /Span <>BDC BT 11 0 0 11 395.3097 398.6817 Tm (clinically appropriate, may be considered if clinical )Tj ET EMC /Span <>BDC BT 11 0 0 11 395.3097 386.6817 Tm (suggestion of recurrent disease.)Tj ET EMC /Span <>BDC BT 11 0 0 11 314.2369 302.6717 Tm (Abnormal)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 314.2369 290.6717 Tm <00bf00510047004c0051004a0056>Tj ET EMC 1 w q 1 0 0 1 393.1497 265.7357 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 674.7316 335.616 cm 0 0 m 0 -69.88 l S Q 0.75 w q 1 0 0 1 395.3097 325.5062 cm 0 0 m 95.938 0 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 395.3097 326.6717 Tm (Additional workup)Tj ET EMC /Span <>BDC BT 11 0 0 11 395.3097 314.6717 Tm (If iodine)Tj /Span<>> BDC (-)Tj EMC (131 imaging negative and stimulated Tg )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 395.3097 302.6717 Tm <0021001500b1001800030051004a00120050002f000f00030046005200510056004c0047004800550003004400470047004c0057004c005200510044004f0003005100520051005500440047004c0052004c00520047004c005100480003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 395.3097 290.6717 Tm (imaging \(eg, central and lateral neck compartments )Tj ET EMC /Span <>BDC BT 11 0 0 11 395.3097 278.6717 Tm (ultrasound, neck CT with contrast, chest CT with )Tj ET EMC /Span <>BDC BT 11 0 0 11 395.3097 266.6717 Tm (contrast, PET/CT\))Tj ET EMC /Artifact <>BDC 1 w 4 M /GS1 gs q 1 0 0 1 369.68 300.6758 cm 0 0 m 14.606 0 l S Q q 1 0 0 1 389.7484 300.6758 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 695.148 427.7457 cm 0 0 m 0 33.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 700.9711 427.5162 cm 0 0 m 54.21 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 697.308 452.6817 Tm (Recurrent )Tj ET EMC /Span <>BDC BT 11 0 0 11 697.308 440.6817 Tm (disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 740.7279 440.6817 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 697.308 428.6817 Tm (\()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 700.9711 428.6817 Tm [(See P)74.1 (AP-9)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 755.1815 428.6817 Tm (\))Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS1 gs q 1 0 0 1 678.728 444.6859 cm 0 0 m 9.541 0 l S Q q 1 0 0 1 693.7316 444.6859 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 678.728 300.6758 cm 0 0 m 9.541 0 l S Q q 1 0 0 1 693.7316 300.6758 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 695.148 259.7357 cm 0 0 m 0 81.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 700.9711 307.5062 cm 0 0 m 54.21 0 l S Q q 1 0 0 1 697.308 259.5062 cm 0 0 m 67.612 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 697.308 332.6717 Tm (Recurrent )Tj ET EMC /Span <>BDC BT 11 0 0 11 697.308 320.6717 Tm (disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 740.7279 320.6717 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 697.308 308.6717 Tm (\()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 700.9711 308.6717 Tm [(See P)74.1 (AP-9)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 755.1815 308.6717 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 758.8446 308.6717 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 697.308 296.6717 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 697.308 284.6717 Tm (Metastatic )Tj ET EMC /Span <>BDC BT 11 0 0 11 697.308 272.6717 Tm (disease)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 737.6718 272.6717 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 697.308 260.6717 Tm (\()Tj ET EMC /Span <>BDC BT -0.004 Tw 11 0 0 11 700.9711 260.6717 Tm [(See P)74.2 (AP-10\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 0.034 Tc -0.034 Tw 11 0 0 11 314.4303 514.3517 Tm (FINDINGS)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS1 gs q 1 0 0 1 307.5736 312.182 cm 0 0 m -20.476 51.254 l -0.209 102.501 l S Q q 1 0 0 1 309.6 307.1096 cm 0 0 m -0.232 7.459 l -4.971 5.565 l h f Q q 1 0 0 1 309.3731 419.762 cm 0 0 m -4.952 -5.582 l -0.206 -7.459 l h f Q EMC endstream endobj 311 0 obj 13280 endobj %% Contents for page 19 %% Original object ID: 39 0 312 0 obj << /Length 313 0 R >> stream Q q BT /Xi17 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 313 0 obj 245 endobj %% Original object ID: 349 0 314 0 obj [ 2258 0 R 2259 0 R 2260 0 R 2261 0 R 2262 0 R 2263 0 R 2264 0 R 2265 0 R 2266 0 R ] endobj %% Contents for page 20 %% Original object ID: 40 0 315 0 obj << /Length 316 0 R >> stream q endstream endobj 316 0 obj 2 endobj %% Contents for page 20 %% Original object ID: 350 0 317 0 obj << /Length 318 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Papillary Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf -0.039 Tc 0.039 Tw 11 0 0 11 735.9072 23.544 Tm [(PA)-74.4 (P)-56.5 (-)-39 (9)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 188.7768 503.5183 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 494.574 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 494.574 Tm [(Stimulated Tg 1\22610 ng/mL)19 ( )]TJ ET EMC /Span <>BDC BT 11 0 0 11 30.744 482.574 Tm (and negative imaging)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 470.574 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 470.574 Tm (Non-resectable tumors)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 458.574 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 458.574 Tm (Non-radioiodine responsive)Tj ET EMC /Span <>BDC BT 9 0 0 9 175.9166 462.574 Tm (cc)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 190.08 480.5782 cm 0 0 m 7.622 0 l S Q q 1 0 0 1 203.164 480.5782 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 203.164 476.574 Tm (Suppress TSH with levothyroxine)Tj ET EMC /Span <>BDC BT 9 0 0 9 377.977 480.574 Tm (j)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 293.6517 Tm (Locoregional )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 281.6517 Tm (recurrence)Tj ET EMC 10 M q 1 0 0 1 201.004 226.7157 cm 0 0 m 0 153.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 324.7562 262.4862 cm 0 0 m 234.556 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 203.164 371.6517 Tm (Surgery \(preferred\) if resectable)Tj ET EMC /Span <>BDC BT 9 0 0 9 370.6723 375.6517 Tm (ee)Tj ET EMC /Span <>BDC BT 11 0 0 11 203.164 359.6517 Tm (and/or )Tj ET EMC /Span <>BDC BT 11 0 0 11 203.164 347.6517 Tm (Radioiodine treatment,)Tj ET EMC /Span <>BDC BT 9 0 0 9 322.3432 351.6517 Tm (dd )Tj ET EMC /Span <>BDC BT 11 0 0 11 335.8388 347.6517 Tm (if radioiodine imaging positive )Tj ET EMC /Span <>BDC BT 11 0 0 11 203.164 335.6517 Tm (or)Tj ET EMC /Span <>BDC BT -0.002 Tw 11 0 0 11 203.164 323.6517 Tm [(Disease )-0.8 (monitoring )0.7 (for non-progressive disease that is stable and distant from critical structures) ]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 203.164 311.6517 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 203.164 299.6517 Tm (For select patients with unresectable, non\226radioiodine-avid, and progressive disease, consider: ) Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 206.764 287.6517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 217.764 287.6517 Tm (EBRT \(IMRT/SBRT\))Tj ET EMC /Span <>BDC BT 9 0 0 9 317.9725 291.6517 Tm (o)Tj ET EMC /Span <>BDC BT 11 0 0 11 323.4701 287.6517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 217.564 275.6517 Tm (and/or)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 206.764 263.6517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 217.764 263.6517 Tm (Systemic therapies \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 324.7562 263.6517 Tm [(See T)55.2 (reatment of Metastatic Disease P)73 (AP-10\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 203.164 251.6517 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 203.164 239.6517 Tm (For select patients with limited burden nodal disease, consider local therapies when available ) Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 203.164 227.6517 Tm [<000b00480057004b004400510052004f000300440045004f00440057004c00520051000f0003005500440047004c005200490055004800540058004800510046005c000300440045004f00440057004c005200510003003e00350029>57.2 <00240040000c>]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.544 180.2945 Tm (Metastatic disease)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 126 184.2986 cm 0 0 m 67.258 0 l S Q q 1 0 0 1 198.72 184.2986 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 201.004 155.3585 cm 0 0 m 0 57.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 203.164 155.129 cm 0 0 m 60.328 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 203.164 204.2945 Tm (RAI therapy for iodine)Tj /Span<>> BDC (-)Tj EMC (avid disease)Tj ET EMC /Span <>BDC BT 9 0 0 9 387.1562 208.2945 Tm (o)Tj ET EMC /Span <>BDC BT 11 0 0 11 203.164 192.2945 Tm (and/or)Tj ET EMC /Span <>BDC BT 11 0 0 11 203.164 180.2945 Tm (Local therapies when available)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 9 0 0 9 364.56 184.2945 Tm <1087>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 203.164 168.2945 Tm (and/or)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 203.164 156.2945 Tm [(See P)74.1 (AP-)]TJ ET EMC /Span <>BDC BT 11 0 0 11 251.2568 156.2945 Tm (10)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 263.4921 156.2945 Tm ( if not amenable to RAI)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 180.8666 291.6558 cm 0 0 m 12.924 0 l S Q q 1 0 0 1 199.2533 291.6558 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 0.035 Tc -0.042 Tw 11 0 0 11 23.7374 514.3517 Tm [(RECURRENT)17.6 ( DISEASE)]TJ ET EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 29.304 85.3276 cm 0 0 m 202.666 0 l S Q q 1 0 0 1 29.304 74.3276 cm 0 0 m 245.474 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 0 Tc 0 Tw 8 0 0 8 23.544 89.3872 Tm (j)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.304 86.3872 Tm [(See Principle)-0.8 (s of )18.2 (TSH Suppression \(THYR-A\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 231.97 86.3872 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 78.3872 Tm (o)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.304 75.3872 Tm (See )Tj ET EMC /Span <>BDC BT 10 0 0 10 49.8753 75.3872 Tm [(Principle)-0.8 (s of Radiation )-0.7 (and RAI )18.1 (Therapy \(THYR)]TJ /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 274.7776 75.3872 Tm (.)Tj ET EMC /GS1 gs q 1 0 0 1 452.0935 96.3276 cm 0 0 m 245.474 0 l S Q /Span <>BDC BT /GS0 gs 8 0 0 8 400.3914 199.3872 Tm (cc )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 410.614 196.3872 Tm [(Generally)73.4 (, a tumor is considered iodine-responsive if follow-up iodine)]TJ /Span<>> BDC (-)Tj EMC (123 or )Tj ET EMC /Span <>BDC BT 10 0 0 10 410.614 185.3872 Tm (low-dose iodine)Tj /Span<>> BDC (-)Tj EMC (131 \(1\2263 mCi\) whole body diagnostic imaging done 6\22612 mo )Tj ET EMC /Span <>BDC BT 10 0 0 10 410.614 174.3872 Tm (after iodine)Tj /Span<>> BDC (-)Tj EMC (131 treatment is negative or shows decreasing uptake compared )Tj ET EMC /Span <>BDC BT 10 0 0 10 410.614 163.3872 Tm (to pre-treatment scans. It is recommended to use the same preparation and ) Tj ET EMC /Span <>BDC BT 10 0 0 10 410.614 152.3872 Tm [(imaging method employed for the pre-treatment scan and therapy)71.4 (. Favorable )]TJ ET EMC /Span <>BDC BT 10 0 0 10 410.614 141.3872 Tm (response to iodine)Tj /Span<>> BDC (-)Tj EMC (131 treatment is additionally assessed through change in )Tj ET EMC /Span <>BDC BT 10 0 0 10 410.614 130.3872 Tm (volume of known iodine-concentrated lesions by CT/MRI, and by decreasing ) Tj ET EMC /Span <>BDC BT 10 0 0 10 410.614 119.3872 Tm (unstimulated or stimulated thyroglobulin levels.)Tj ET EMC /Span <>BDC BT 8 0 0 8 400.3914 111.3872 Tm (dd )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 411.5125 108.3872 Tm (The administered activity of RAI therapy should be adjusted for pediatric ) Tj ET EMC /Span <>BDC BT 10 0 0 10 411.5125 97.3872 Tm (patients. )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 452.0935 97.3872 Tm (See )Tj ET EMC /Span <>BDC BT 10 0 0 10 472.6648 97.3872 Tm [(Principles of Radiation and RAI )16.4 (Therapy \(THYR)]TJ /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 697.5671 97.3872 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 400.3914 89.3872 Tm (ee )Tj ET EMC /Span <>BDC BT 10 0 0 10 411.5125 86.3872 Tm (Preoperative vocal cord assessment, if central neck recurrence. )Tj ET EMC /Span <>BDC BT -0.018 Tc 0.018 Tw 8 0 0 8 400.3914 78.3872 Tm (ff)Tj /Span<>> BDC 0.538 0 Td ( )Tj EMC ET EMC /Span <>BDC BT 0 Tc 0 Tw 10 0 0 10 406.1514 75.3872 Tm [(Ethanol ablation, cryoablatio)-0.8 (n, RF)55.5 (A, etc. )]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 383.76 480.5782 cm 0 0 m 39.178 0 l S Q q 1 0 0 1 428.4 480.5782 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 429.6 469.638 cm 0 0 m 0 21.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 708.0696 469.4085 cm 0 0 m 61.317 0 l S Q /Span <>BDC BT /GS0 gs /TT1 1 Tf 11 0 0 11 431.76 482.574 Tm (Continue surveillance with unstimulated Tg, )Tj ET EMC /Span <>BDC BT -0.002 Tc 11 0 0 11 431.76 470.574 Tm (ultrasound, and other imaging as clinically indicated )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 708.0696 470.574 Tm [(\(See P)74.2 (AP-8\))]TJ ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 166.7506 443.456 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 0 0 0 scn 0 Tc 11 0 0 11 23.544 434.5117 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 434.5117 Tm (Progressively rising Tg )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 422.5117 Tm (\(basal or stimulated\))Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 410.5117 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 410.5117 Tm (Scans \(including PET\) )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 398.5117 Tm (negative )Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 166.48 420.5159 cm 0 0 m 28.218 0 l S Q q 1 0 0 1 200.16 420.5159 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 201.004 391.5757 cm 0 0 m 0 57.88 l S Q /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 203.164 440.5117 Tm <0026005200510056004c0047004800550003005500440047004c0052004c00520047004c0051004800030057004b0048005500440053005c0003005a004c0057004b00030095001400130013000300500026004c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 432.3002 444.5117 Tm (dd)Tj ET EMC /Span <>BDC BT 11 0 0 11 203.164 428.5117 Tm (and )Tj ET EMC /Span <>BDC BT 11 0 0 11 203.164 416.5117 Tm (Post-treatment iodine)Tj /Span<>> BDC (-)Tj EMC (131 imaging \(category 3\); additional RAI )Tj ET EMC /Span <>BDC BT 11 0 0 11 203.164 404.5117 Tm (treatments should be limited to patients who responded to previous )Tj ET EMC /Span <>BDC BT 11 0 0 11 203.164 392.5117 Tm (RAI therapy \(minimum of 6\22612 months between RAI treatments\))Tj ET EMC q 1 0 0 1 108.7546 268.7157 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 179.1534 314.596 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 11 0 0 11 110.9146 305.6517 Tm (Consider )Tj ET EMC /Span <>BDC BT 11 0 0 11 110.9146 293.6517 Tm (preoperative )Tj ET EMC /Span <>BDC BT 11 0 0 11 110.9146 281.6517 Tm (iodine total )Tj ET EMC /Span <>BDC BT 11 0 0 11 110.9146 269.6517 Tm (body scan)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 97.636 291.6558 cm 0 0 m 5.262 0 l S Q q 1 0 0 1 108.36 291.6558 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC endstream endobj 318 0 obj 15437 endobj %% Contents for page 20 %% Original object ID: 41 0 319 0 obj << /Length 320 0 R >> stream Q q BT /Xi18 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 320 0 obj 245 endobj %% Original object ID: 352 0 321 0 obj [ 2267 0 R 2268 0 R 2269 0 R 2270 0 R 2271 0 R 2272 0 R 2273 0 R 2274 0 R 2275 0 R 2276 0 R 2277 0 R 2278 0 R 2279 0 R ] endobj %% Contents for page 21 %% Original object ID: 42 0 322 0 obj << /Length 323 0 R >> stream q endstream endobj 323 0 obj 2 endobj %% Contents for page 21 %% Original object ID: 353 0 324 0 obj << /Length 325 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Papillary Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 11 0 0 11 729.7895 23.544 Tm [(P)39.1 (A)-35.3 (P)-17.6 (-10)]TJ ET EMC /Span <>BDC BT 11 0 0 11 313.6058 212.6523 Tm (CNS metastases)Tj ET EMC /Span <>BDC BT 0.035 Tc -0.017 Tw 11 0 0 11 23.7374 514.3517 Tm [(TREA)73.9 (TMENT)17.6 ( )0.6 (OF)17.6 ( )0.6 (LOCALL)91.8 (Y)35.5 ( )0.6 (RECURRENT)128.4 (,)35.2 ( )37.7 (ADV)74.1 (ANCED)17.3 (,)35.1 ( )37.7 (AND)17.3 (/)17.5 (OR)17.2 ( )0.6 (MET)74.2 (AST)74.2 (A)73.9 (TIC)17.3 ( )0.6 (DISEASE)17.5 ( )0.5 (NOT)17.6 ( )37.7 (AMENABLE)17.5 ( )0.6 (T)18 (O)17.6 ( )0.6 (RAI)17.6 ( )0.6 (THERAPY)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 428.859 277.8331 cm 0 0 m 0 225.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 665.0081 337.6036 cm 0 0 m 92.893 0 l S Q q 1 0 0 1 438.219 325.6036 cm 0 0 m 103.13 0 l S Q q 1 0 0 1 438.219 289.6036 cm 0 0 m 61.537 0 l S Q q 1 0 0 1 553.4639 277.6036 cm 0 0 m 209.682 0 l S Q /Span <>BDC BT /GS0 gs 0 Tc 0 Tw 11 0 0 11 431.019 494.7691 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 437.9262 494.7691 Tm (Consider systemic therapy)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 434.619 482.7691 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 445.619 482.7691 Tm (For progressive and/or symptomatic disease, consider )Tj ET EMC /Span <>BDC BT 11 0 0 11 445.419 470.7691 Tm (lenvatinib \(preferred\))Tj ET EMC /Span <>BDC BT 9 0 0 9 555.4405 474.7691 Tm (gg )Tj ET EMC /Span <>BDC BT 11 0 0 11 568.9361 470.7691 Tm (or sorafenib)Tj ET EMC /Span <>BDC BT 9 0 0 9 632.503 474.7691 Tm (hh,ii)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 434.619 458.7691 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 445.619 458.7691 Tm (Larotrectinib or entrectinib for patients with )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 677.2474 458.7691 Tm (NTRK)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 707.7982 458.7691 Tm ( gene )Tj ET EMC /Span <>BDC BT 11 0 0 11 445.419 446.7691 Tm (fusion)Tj /Span<>> BDC (-)Tj EMC (positive advanced solid tumors.)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 434.619 434.7691 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 445.619 434.7691 Tm (Selpercatinib for patients with )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 605.7528 434.7691 Tm (RET)Tj ET EMC /Span <>BDC BT /TT1 1 Tf /Span<>> BDC 11 0 0 11 627.7528 434.7691 Tm (-)Tj EMC (fusion positive tumors)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 434.619 422.7691 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 445.619 422.7691 Tm (Pembrolizumab for patients with tumor mutational burden)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 445.419 410.7691 Tm <004b004c004a004b0003000b0037003000250010002b000c0003000b009500140013000300500058005700440057004c005200510056001200500048004a004400450044005600480003003e0050005800570012003000450040000c0003005700580050005200550056>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 434.619 398.7691 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 445.619 398.7691 Tm (Other therapies are available and can be considered for )Tj ET EMC /Span <>BDC BT 11 0 0 11 445.419 386.7691 Tm (progressive and/or symptomatic disease if clinical trials or )Tj ET EMC /Span <>BDC BT 11 0 0 11 445.419 374.7691 Tm (other systemic therapies are not available or appropriate.)Tj ET EMC /Span <>BDC BT 9 0 0 9 744.9703 378.7691 Tm (jj,kk)Tj ET EMC /Span <>BDC BT 11 0 0 11 431.019 362.7691 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 437.9262 362.7691 Tm (Consider resection of distant metastases and/or EBRT \(SBRT/)Tj ET EMC /Span <>BDC BT 11 0 0 11 438.219 350.7691 Tm (IMRT\))Tj ET EMC /Span <>BDC BT 9 0 0 9 468.7644 354.7691 Tm (o)Tj ET EMC /Span <>BDC BT 11 0 0 11 474.262 350.7691 Tm (/other local therapies)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 9 0 0 9 584.9065 354.7691 Tm <10870003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 593.1814 350.7691 Tm (when available to metastatic )Tj ET EMC /Span <>BDC BT 11 0 0 11 438.219 338.7691 Tm (lesions if progressive and/or symptomatic. )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 665.0081 338.7691 Tm (\(For locoregional )Tj ET EMC /Span <>BDC BT 11 0 0 11 438.219 326.7691 Tm [(disease, see P)73.8 (AP-9\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 431.019 314.7691 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 437.9262 314.7691 Tm (Disease monitoring is often appropriate in asymptomatic )Tj ET EMC /Span <>BDC BT 11 0 0 11 438.219 302.7691 Tm (patients with indolent disease assuming no brain metastasis.)Tj ET EMC /Span <>BDC BT 9 0 0 9 758.5188 306.7691 Tm (ii )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 438.219 290.7691 Tm [(\(See P)74.1 (AP-8\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 431.019 278.7691 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 437.9262 278.7691 Tm (Best supportive care \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 553.4638 278.7691 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 576.0922 278.7691 Tm (NCCN Guidelines for Palliative Care)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 763.1459 278.7691 Tm (\))Tj ET EMC /GS1 gs q 1 0 0 1 29.304 162.3276 cm 0 0 m 202.666 0 l S Q q 1 0 0 1 29.304 151.3276 cm 0 0 m 245.474 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 8 0 0 8 23.544 166.3872 Tm (j)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.304 163.3872 Tm [(See Principle)-0.8 (s of )18.2 (TSH Suppression \(THYR-A\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 231.97 163.3872 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 155.3872 Tm (o)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.304 152.3872 Tm (See )Tj ET EMC /Span <>BDC BT 10 0 0 10 49.8753 152.3872 Tm [(Principle)-0.8 (s of Radiation )-0.7 (and RAI )18.1 (Therapy \(THYR)]TJ /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 274.7776 152.3872 Tm (.)Tj ET EMC /Span <>BDC BT -0.018 Tc 0.018 Tw 8 0 0 8 23.544 144.3872 Tm [(ff)-17.8 ( )]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 10 0 0 10 30.0674 141.3872 Tm [(Ethanol ablation, cryoablation, RF)53.4 (A, etc. )]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.544 133.3872 Tm (gg )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 34.6651 130.3872 Tm (In a subset of patients \(older than 65 years of age\), lenvatinib showed an ) Tj ET EMC /Span <>BDC BT 10 0 0 10 34.6651 119.3872 Tm (overall survival benefit compared to placebo. Brose MS, et al. J Clin Oncol ) Tj ET EMC /Span <>BDC BT 10 0 0 10 34.6651 108.3872 Tm (2017;35:2692-2699.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 100.3872 Tm (hh )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 34.6651 97.3872 Tm (The decision of whether to use lenvatinib \(preferred\) or sorafenib should ) Tj ET EMC /Span <>BDC BT 10 0 0 10 34.6651 86.3872 Tm (be individualized for each patient based on likelihood of response and )Tj ET EMC /Span <>BDC BT 10 0 0 10 34.6651 75.3872 Tm (comorbidities.)Tj ET EMC /GS1 gs q 1 0 0 1 568.132 151.3276 cm 0 0 m 188.809 0 l S Q q 1 0 0 1 405.8273 140.3276 cm 0 0 m 46.66 0 l S Q /Span <>BDC BT /GS0 gs 8 0 0 8 400.05 166.3872 Tm (ii )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 405.8273 163.3872 Tm (Kinase inhibitor therapy may not be appropriate for patients with stable or ) Tj ET EMC /Span <>BDC BT 10 0 0 10 405.8273 152.3872 Tm (slowly progressive indolent disease. )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 568.132 152.3872 Tm [(See Principles of Kinase Inhibitor )16.4 (Therapy )]TJ ET EMC /Span <>BDC BT 10 0 0 10 405.8273 141.3872 Tm (\(THYR-B\).)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 8 0 0 8 400.05 133.3872 Tm (jj )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 405.8273 130.3872 Tm (Commercially available small-molecule kinase inhibitors \(such as axitinib, ) Tj ET EMC /Span <>BDC BT 10 0 0 10 405.8273 119.3872 Tm (everolimus, pazopanib, sunitinib, vandetanib, vemurafenib [)Tj ET EMC /Span <>BDC BT /TT3 1 Tf 10 0 0 10 668.7619 119.3872 Tm (BRAF)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 10 0 0 10 695.4318 119.3872 Tm ( positive], )Tj ET EMC /Span <>BDC BT 10 0 0 10 405.8273 108.3872 Tm (dabrafenib [)Tj ET EMC /Span <>BDC BT /TT3 1 Tf 10 0 0 10 458.6447 108.3872 Tm (BRAF)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 10 0 0 10 485.3146 108.3872 Tm ( positive], or cabozantinib [all are category 2A]\) can be )Tj ET EMC /Span <>BDC BT 10 0 0 10 405.8273 97.3872 Tm (considered if clinical trials are not available or appropriate. )Tj ET EMC /Span <>BDC BT 8 0 0 8 400.05 89.3872 Tm (kk )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 410.2726 86.3872 Tm [(Cytotoxic chemotherapy has been shown to have minimal ef)15.4 (ficacy)74.1 (, although )]TJ ET EMC /Span <>BDC BT 10 0 0 10 410.2726 75.3872 Tm (most studies were small and underpowered. )Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 129 371.0029 cm 0 0 m 0 -81.88 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.044 362.0586 Tm (Structurally )Tj ET EMC /Span <>BDC BT -0.001 Tc 0.001 Tw 11 0 0 11 23.044 350.0586 Tm [(pe)-0.6 (rs)-0.6 (iste)-0.6 (nt/re)-0.6 (curr)-0.6 (ent)-1 ( )]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.044 338.0586 Tm (locoregional or )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.044 326.0586 Tm (distant metastatic )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.044 314.0586 Tm (disease not )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.044 302.0586 Tm (amenable to RAI )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.044 290.0586 Tm (therapy)Tj ET EMC /Span <>BDC BT 11 0 0 11 313.6058 257.9917 Tm (Bone metastases)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 412 481.8252 cm 0 0 m 0 -158.104 l S Q EMC /Artifact <>BDC q 1 0 0 1 414 402.7733 cm 0 0 m 7.71 0 l S Q q 1 0 0 1 427.1722 402.7733 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 406.549 261.9959 cm 0 0 m 15.161 0 l S Q q 1 0 0 1 427.1722 261.9959 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 302.7239 228.4702 cm 0 0 m -28.605 101.593 l -0.29 203.181 l S Q q 1 0 0 1 304.2043 223.2124 cm 0 0 m 0.556 7.441 l -4.357 6.058 l h f Q q 1 0 0 1 303.9009 436.9131 cm 0 0 m -4.341 -6.07 l 0.575 -7.44 l h f Q EMC /Artifact <>BDC q 1 0 0 1 301.8197 286.8109 cm 0 0 m -27.627 43.252 l -0.287 86.49 l S Q q 1 0 0 1 304.76 282.2076 cm 0 0 m -1.624 7.283 l -5.925 4.536 l h f Q q 1 0 0 1 304.4518 377.9179 cm 0 0 m -5.904 -4.563 l -1.591 -7.291 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 309.4568 433.8331 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 309.4568 325.8331 cm 0 0 m 0 69.88 l S Q /Span <>BDC BT 11 0 0 11 311.6168 470.7691 Tm (Unresectable )Tj ET EMC /Span <>BDC BT 11 0 0 11 311.6168 458.7691 Tm (locoregional )Tj ET EMC /Span <>BDC BT 11 0 0 11 311.6168 446.7691 Tm (recurrent/)Tj ET EMC /Span <>BDC BT -0.03 Tw 11 0 0 11 311.6168 434.7691 Tm (persistent disease)Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 311.6168 410.7691 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 311.6168 386.7691 Tm (Soft tissue )Tj ET EMC /Span <>BDC BT 11 0 0 11 311.6168 374.7691 Tm (metastases )Tj ET EMC /Span <>BDC BT 11 0 0 11 311.6168 362.7691 Tm [(\(eg, lung, liver)56.4 (, )]TJ ET EMC /Span <>BDC BT -0.028 Tw 11 0 0 11 311.6168 350.7691 Tm (muscle\) excluding )Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 311.6168 338.7691 Tm (CNS metastases )Tj ET EMC /Span <>BDC BT 11 0 0 11 311.6168 326.7691 Tm (\(see below\))Tj ET EMC 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 431.019 256.8262 cm 0 0 m 59.721 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 431.019 257.9917 Tm [(See P)74.1 (AP-1)]TJ ET EMC /Span <>BDC BT 11 0 0 11 484.6225 257.9917 Tm (1)Tj ET EMC q 1 0 0 1 431.019 211.4868 cm 0 0 m 59.721 0 l S Q /Span <>BDC BT 11 0 0 11 431.019 212.6524 Tm [(See P)74.1 (AP-1)]TJ ET EMC /Span <>BDC BT 11 0 0 11 484.6225 212.6524 Tm (1)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 402.8768 216.6566 cm 0 0 m 18.833 0 l S Q 0 0 0 scn q 1 0 0 1 427.1722 216.6566 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 145.68 235.1226 cm 0 0 m 0 165.88 l S Q q 1 0 0 1 272.1369 401.0029 cm 0 0 m 0 -165.88 l S Q /Span <>BDC BT 11 0 0 11 147.84 392.0586 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 154.7472 392.0586 Tm (Continue to )Tj ET EMC /Span <>BDC BT 11 0 0 11 155.04 380.0586 Tm (suppress TSH with )Tj ET EMC /Span <>BDC BT 11 0 0 11 155.04 368.0586 Tm (levothyroxine)Tj ET EMC /Span <>BDC BT 9 0 0 9 226.5615 372.0586 Tm (j)Tj ET EMC /Span <>BDC BT 11 0 0 11 147.84 356.0586 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 154.7472 356.0586 Tm (For advanced, )Tj ET EMC /Span <>BDC BT 11 0 0 11 155.04 344.0586 Tm (progressive, or )Tj ET EMC /Span <>BDC BT 11 0 0 11 155.04 332.0586 Tm (threatening disease, )Tj ET EMC /Span <>BDC BT 11 0 0 11 155.04 320.0586 Tm (genomic testing to )Tj ET EMC /Span <>BDC BT 11 0 0 11 155.04 308.0586 Tm (identify actionable )Tj ET EMC /Span <>BDC BT 11 0 0 11 155.04 296.0586 Tm (mutations \(including )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 155.04 284.0586 Tm (NTRK)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 185.5908 284.0586 Tm ( and )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 211.2592 284.0586 Tm (RET)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 233.2592 284.0586 Tm ( gene )Tj ET EMC /Span <>BDC BT 11 0 0 11 155.04 272.0586 Tm (fusions\) and tumor )Tj ET EMC /Span <>BDC BT 11 0 0 11 155.04 260.0586 Tm (mutational burden )Tj ET EMC /Span <>BDC BT 11 0 0 11 155.04 248.0586 Tm (\(TMB\))Tj ET EMC /Span <>BDC BT 11 0 0 11 147.84 236.0586 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 154.7472 236.0586 Tm (Consider clinical trial)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 130.8781 330.0628 cm 0 0 m 6.94 0 l S Q q 1 0 0 1 143.28 330.0628 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC endstream endobj 325 0 obj 19483 endobj %% Contents for page 21 %% Original object ID: 43 0 326 0 obj << /Length 327 0 R >> stream Q q BT /Xi19 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 327 0 obj 245 endobj %% Original object ID: 355 0 328 0 obj [ 2280 0 R 2281 0 R 2282 0 R 2283 0 R 2284 0 R 2285 0 R 2286 0 R ] endobj %% Contents for page 22 %% Original object ID: 44 0 329 0 obj << /Length 330 0 R >> stream q endstream endobj 330 0 obj 2 endobj %% Contents for page 22 %% Original object ID: 356 0 331 0 obj << /Length 332 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Papillary Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf -0.055 Tc 0.055 Tw 11 0 0 11 730.3964 23.544 Tm [(P)-15.9 (A)-90.3 (P)-72.6 (-)-55 (11)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 177.98 161.9533 cm 0 0 m 0 163.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 302.5848 161.7238 cm 0 0 m 209.682 0 l S Q /Span <>BDC BT /GS0 gs 0 Tc 0 Tw 11 0 0 11 180.14 316.8893 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 187.0472 316.8893 Tm (For solitary CNS lesions, either neurosurgical resection or stereotactic radiosurgery is preferred) Tj ET EMC /Span <>BDC BT 11 0 0 11 690.7699 316.8893 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 187.34 305.8893 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 180.14 294.8893 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 187.0472 294.8893 Tm [(For multiple CNS lesions, consider radiotherapy)75.7 (, including image-guided radiotherapy)76.4 (, and/or resection in )]TJ ET EMC /Span <>BDC BT 11 0 0 11 187.34 283.8893 Tm (select cases)Tj ET EMC /Span <>BDC BT 11 0 0 11 252.1745 283.8893 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 187.34 272.8893 Tm (and/or)Tj ET EMC /Span <>BDC BT 11 0 0 11 180.14 261.8893 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 187.0472 261.8893 Tm (Consider systemic therapy)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 183.74 250.8893 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 194.74 250.8893 Tm (For progressive and/or symptomatic disease, consider lenvatinib \(preferred\) or sorafenib) Tj ET EMC /Span <>BDC BT 9 0 0 9 660.5374 254.8893 Tm (hh,nn,oo)Tj ET EMC /Span <>BDC BT 9 0 0 9 698.5237 254.8893 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 194.54 239.8893 Tm (and/or)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 183.74 228.8893 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 194.74 228.8893 Tm (Larotrectinib or entrectinib for patients with )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 426.3684 228.8893 Tm (NTRK)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 456.9192 228.8893 Tm ( gene fusion)Tj /Span<>> BDC (-)Tj EMC (positive advanced solid tumors)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 183.74 217.8893 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 194.74 217.8893 Tm (Selpercatinib for patients with )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 354.8738 217.8893 Tm (RET)Tj ET EMC /Span <>BDC BT /TT1 1 Tf /Span<>> BDC 11 0 0 11 376.8738 217.8893 Tm (-)Tj EMC (fusion positive tumors)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 183.74 206.8893 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 194.74 206.8893 Tm <003300480050004500550052004f004c005d005800500044004500030049005200550003005300440057004c00480051005700560003005a004c0057004b00030037003000250010002b0003000b0095001400130003005000580057001200300045000c0003005700580050005200550056>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 514.2825 206.8893 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 194.54 195.8893 Tm (and/or)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 183.74 184.8893 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 194.74 184.8893 Tm (Other therapies are available and can be considered for progressive and/or symptomatic disease if clinical ) Tj ET EMC /Span <>BDC BT 11 0 0 11 194.54 173.8893 Tm (trials or other systemic therapies are not available or appropriate.)Tj ET EMC /Span <>BDC BT 9 0 0 9 537.4951 177.8893 Tm (ii,jj,kk,nn)Tj ET EMC /Span <>BDC BT 11 0 0 11 180.14 162.8893 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 187.0472 162.8893 Tm (Best supportive care \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 302.5848 162.8893 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 325.2132 162.8893 Tm (NCCN Guidelines for Palliative Care)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 512.267 162.8893 Tm (\))Tj ET EMC /Span <>BDC BT 0.035 Tc -0.017 Tw 11 0 0 11 23.7374 514.3517 Tm [(TREA)73.9 (TMENT)17.6 ( )0.6 (OF)17.6 ( )0.6 (MET)74.2 (AST)74.2 (A)73.9 (TIC)17.3 ( )0.5 (DISEASE)17.4 ( )0.6 (NOT)17.6 ( )37.7 (AMENABLE)17.5 ( )0.6 (T)18 (O)17.6 ( )0.6 (RAI)17.6 ( )0.6 (THERAPY)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 9 0 0 9 438.4503 518.3517 Tm (mm)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.044 239.8893 Tm (CNS metastases)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS1 gs q 1 0 0 1 117.36 243.8935 cm 0 0 m 49.478 0 l S Q q 1 0 0 1 172.3 243.8935 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.637 w 10 M q 1 0 0 1 94.5972 110.4865 cm 0 0 m 197.787 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf -0.018 Tc 0.018 Tw 6.8 0 0 6.8 23.544 149.9372 Tm [(ff)-17.8 ( )]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 8.5 0 0 8.5 29.0889 147.3872 Tm [(Ethanol ablation, cryoablation, RF)53.4 (A, etc. )]TJ ET EMC /Span <>BDC BT 6.8 0 0 6.8 23.544 140.9372 Tm (hh )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 32.9969 138.3872 Tm (The decision of whether to use lenvatinib \(preferred\) or sorafenib should be individualized for ) Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 32.9969 129.3872 Tm (each patient based on likelihood of response and comorbidities.)Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 23.544 122.9372 Tm (ii )Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 28.4547 120.3872 Tm (Kinase inhibitor therapy may not be appropriate for patients with stable or slowly progressive ) Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 28.44 111.3872 Tm (indolent disease. )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 8.5 0 0 8.5 94.5972 111.3872 Tm [(See Principles of Kinase Inhibitor )16.4 (Therapy \(THYR-B\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 8.5 0 0 8.5 292.3841 111.3872 Tm (.)Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 23.544 104.9372 Tm (jj )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 28.4547 102.3872 Tm (Commercially available small-molecule kinase inhibitors \(such as axitinib, everolimus, ) Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 28.4547 93.3872 Tm (pazopanib, sunitinib, vandetanib, vemurafenib [)Tj ET EMC /Span <>BDC BT /TT3 1 Tf 8.5 0 0 8.5 206.1288 93.3872 Tm (BRAF)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 8.5 0 0 8.5 228.7982 93.3872 Tm ( positive], dabrafenib [)Tj ET EMC /Span <>BDC BT /TT3 1 Tf 8.5 0 0 8.5 311.9596 93.3872 Tm (BRAF)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 8.5 0 0 8.5 334.6291 93.3872 Tm ( positive], )Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 28.4547 84.3872 Tm (or cabozantinib [all are category 2A]\) can be considered if clinical trials are not available or ) Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 28.4547 75.3872 Tm (appropriate.)Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 399.4425 149.9372 Tm (kk )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 408.1317 147.3872 Tm [(Cytotoxic chemotherapy has been shown to have minimal ef)15.4 (ficacy)74.1 (, although most studies were )]TJ ET EMC /Span <>BDC BT 8.5 0 0 8.5 408.1317 138.3872 Tm (small and underpowered. )Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 399.4425 131.9372 Tm (ll )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 404.3532 129.3872 Tm (Denosumab and intravenous bisphosphonates can be associated with severe hypocalcemia; ) Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 404.3532 120.3872 Tm (patients with hypoparathyroidism and vitamin D deficiency are at increased risk of hypocalcemia.) Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 399.4425 113.9372 Tm (mm )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 412.6606 111.3872 Tm (RAI therapy is an option in some patients with bone metastases and RAI)Tj /Span<>> BDC (-)Tj EMC (sensitive disease.)Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 399.4425 104.9372 Tm (nn )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 408.8954 102.3872 Tm [(After consultation with neurosurgery and radiation oncology)70.8 (, data on the ef)18.2 (ficacy of lenvatinib or )]TJ ET EMC /Span <>BDC BT 8.5 0 0 8.5 408.8954 93.3872 Tm (sorafenib for patients with brain metastases have not been established.)Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 399.4425 86.9372 Tm (oo )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 408.8954 84.3872 Tm (TKI therapy should be used with caution in otherwise untreated CNS metastases due to ) Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 408.8954 75.3872 Tm (bleeding risk.)Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 177.98 339.1147 cm 0 0 m 0 163.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 653.6 426.8852 cm 0 0 m 61.537 0 l S Q q 1 0 0 1 302.5848 338.8852 cm 0 0 m 209.682 0 l S Q /Span <>BDC BT /GS0 gs /TT1 1 Tf 11 0 0 11 180.14 494.0507 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 187.0472 494.0507 Tm (Consider surgical palliation and/or EBRT/SBRT/other local therapies)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 9 0 0 9 544.6117 498.0507 Tm <1087>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 550.3861 494.0507 Tm ( when available if symptomatic, or )Tj ET EMC /Span <>BDC BT 11 0 0 11 187.34 483.0507 Tm (asymptomatic in weight-bearing sites. Embolization prior to surgical resection of bone metastases should be ) Tj ET EMC /Span <>BDC BT 11 0 0 11 187.34 472.0507 Tm (considered to reduce the risk of hemorrhage.)Tj ET EMC /Span <>BDC BT 11 0 0 11 180.14 461.0507 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 187.0472 461.0507 Tm (Consider embolization or other interventional procedures as alternatives to surgical resection/EBRT/IMRT in ) Tj ET EMC /Span <>BDC BT 11 0 0 11 187.34 450.0507 Tm (select cases.)Tj ET EMC /Span <>BDC BT 11 0 0 11 180.14 439.0507 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 187.0472 439.0507 Tm (Consider intravenous bisphosphonate or denosumab.)Tj ET EMC /Span <>BDC BT 9 0 0 9 470.0233 443.0507 Tm (ll)Tj ET EMC /Span <>BDC BT 11 0 0 11 180.14 428.0507 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 187.0472 428.0507 Tm (Disease monitoring may be appropriate in asymptomatic patients with indolent disease.) Tj ET EMC /Span <>BDC BT 9 0 0 9 646.0985 432.0507 Tm (ii )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 653.6 428.0507 Tm [(\(See P)74.1 (AP-8\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 180.14 417.0507 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 187.0472 417.0507 Tm (Consider systemic therapy)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 183.74 406.0507 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 194.74 406.0507 Tm (For progressive and/or symptomatic disease, consider lenvatinib \(preferred\) or sorafenib.) Tj ET EMC /Span <>BDC BT 9 0 0 9 663.5935 410.0507 Tm (hh)Tj ET EMC /Span <>BDC BT 11 0 0 11 674.5886 406.0507 Tm ( )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 183.74 395.0507 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 194.74 395.0507 Tm (Larotrectinib or entrectinib for patients with )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 426.3684 395.0507 Tm (NTRK)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 456.9192 395.0507 Tm ( gene fusion)Tj /Span<>> BDC (-)Tj EMC (positive advanced solid tumors.)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 183.74 384.0507 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 194.74 384.0507 Tm (Selpercatinib for patients with )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 354.8738 384.0507 Tm (RET)Tj ET EMC /Span <>BDC BT /TT1 1 Tf /Span<>> BDC 11 0 0 11 376.8738 384.0507 Tm (-)Tj EMC (fusion positive tumors)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 183.74 373.0507 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 194.74 373.0507 Tm <003300480050004500550052004f004c005d005800500044004500030049005200550003005300440057004c00480051005700560003005a004c0057004b00030037003000250010002b0003000b0095001400130003005000580057001200300045000c0003005700580050005200550056>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 183.74 362.0507 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 194.74 362.0507 Tm (Other therapies are available and can be considered for progressive and/or symptomatic disease if clinical ) Tj ET EMC /Span <>BDC BT 11 0 0 11 194.54 351.0507 Tm (trials or other systemic therapies are not available or appropriate.)Tj ET EMC /Span <>BDC BT 9 0 0 9 537.4951 355.0507 Tm (ii,jj,kk)Tj ET EMC /Span <>BDC BT 11 0 0 11 180.14 340.0507 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 187.0472 340.0507 Tm (Best supportive care \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 302.5848 340.0507 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 325.2132 340.0507 Tm (NCCN Guidelines for Palliative Care)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 512.267 340.0507 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 23.044 417.0507 Tm (Bone metastases)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS1 gs q 1 0 0 1 130.6878 421.0549 cm 0 0 m 36.15 0 l S Q q 1 0 0 1 172.3 421.0549 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC endstream endobj 332 0 obj 17806 endobj %% Contents for page 22 %% Original object ID: 45 0 333 0 obj << /Length 334 0 R >> stream Q q BT /Xi20 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 334 0 obj 245 endobj %% Original object ID: 358 0 335 0 obj [ 2287 0 R 2288 0 R 2289 0 R 2290 0 R 2291 0 R 2292 0 R 2293 0 R 2294 0 R 2295 0 R 2296 0 R 2297 0 R 2298 0 R 2299 0 R 2300 0 R ] endobj %% Contents for page 23 %% Original object ID: 46 0 336 0 obj << /Length 337 0 R >> stream q endstream endobj 337 0 obj 2 endobj %% Contents for page 23 %% Original object ID: 359 0 338 0 obj << /Length 339 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Follicular Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q q 1 0 0 1 370.5833 174.3276 cm 0 0 m 18.901 0 l S Q q 1 0 0 1 29.304 164.3276 cm 0 0 m 28.159 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs 8 0 0 8 23.544 228.3872 Tm (a)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 225.3872 Tm [(The diagnosis)-0.7 ( of follicular ca)-0.8 (rcinoma requires evidence o)-2 (f either vascular or )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 215.3872 Tm (capsular invasion, which cannot be determined by FNA. Molecular diagnostics ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.304 205.3872 Tm [(may be useful to allow reclassification of follicular lesions \(follicular neoplasm o) -2.8 (r )]TJ ET EMC /Span <>BDC BT -0.002 Tc -0.002 Tw 10 0 0 10 29.304 195.3872 Tm [(FLUS\) as either more or less likely to be benign or malignant based on the genetic) -2 ( )]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 10 0 0 10 29.304 185.3872 Tm (profile. If molecular testing in conjunction with clinical and ultrasound features ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.304 175.3872 Tm (suggests papillary thyroid carcinoma, especially in the case of )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 10 0 0 10 305.554 175.3872 Tm (BRAF)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 10 0 0 10 332.2239 175.3872 Tm ( V600E, )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 370.5833 175.3872 Tm (see )Tj ET EMC /Span <>BDC BT 10 0 0 10 29.304 165.3872 Tm [(P)74.2 (AP-1)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 57.4632 165.3872 Tm (.)Tj ET EMC /Span <>BDC BT 10 0 0 10 60.2415 165.3872 Tm ( Molecular markers should be interpreted with caution and in the context of ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.304 155.3872 Tm (clinical, radiographic, and cytologic features of each individual patient.) Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 148.3872 Tm (b)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 145.3872 Tm [(Use of iodina)-0.8 (ted contrast is required for optimal cervical i)-1.6 (maging using CT)109.8 (; )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 135.3872 Tm (potential delay in RAI treatment will not cause harm.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 129.3872 Tm (c)Tj ET EMC /Span <>BDC BT /Span<>> BDC 9 0 0 9 27.544 129.3872 Tm ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 125.3872 Tm [(V)55.2 (ocal cord mobility may be examined in patients with abn)-1.7 (ormal voice, surgical )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 115.3872 Tm (history involving the recurrent laryngeal or vagus nerves, invasive disease, or ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.304 105.3872 Tm (bulky disease of the central neck.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 98.3872 Tm (d)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 95.3872 Tm [(Minimally inva)-0.6 (sive follicular )-0.9 (thyroid carcinoma \(FTC\) is ch)-0.8 (aracterized as an )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 85.3872 Tm (encapsulated tumor with microscopic capsular invasion and without vascular ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.304 75.3872 Tm (invasion.)Tj ET EMC /GS1 gs q 1 0 0 1 406.26 74.3276 cm 0 0 m 202.666 0 l S Q /Span <>BDC BT /GS0 gs 8 0 0 8 400.5 108.3872 Tm (e)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 406.26 105.3872 Tm [(Formerly calle)-0.6 (d encapsulate)-0.9 (d follicular variant of PTC, no)-0.7 (ninvasive follicular )]TJ ET EMC /Span <>BDC BT 10 0 0 10 406.26 95.3872 Tm [(thyroid neoplasm with NIFTP)17.2 ( has been reclassified and only lobectomy is )]TJ ET EMC /Span <>BDC BT 10 0 0 10 406.26 85.3872 Tm (needed. Ongoing surveillance is recommended.)Tj ET EMC /Span <>BDC BT 8 0 0 8 400.5 78.3872 Tm (f)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 406.26 75.3872 Tm [(See Principle)-0.8 (s of )18.2 (TSH Suppression \(THYR-A\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 608.926 75.3872 Tm (.)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 728.6078 23.544 Tm [(FOLL)17.6 (-)35 (1)]TJ ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 24.5534 514.3517 Tm [(FNA)54.3 ( )0.6 (RESUL)74.2 (TS)]TJ ET EMC /Span <>BDC BT -0.035 Tw 11 0 0 11 126.9134 514.3517 Tm [(DIAGNOSTIC)17.2 ( )]TJ ET EMC /Span <>BDC BT 11 0 0 11 126.9134 502.3517 Tm (PROCEDURES)Tj ET EMC /Span <>BDC BT -0.082 Tw 11 0 0 11 317.5934 514.3517 Tm [(PRIMAR)36.8 (Y)35.5 ( )0.5 (TREA)73.9 (TMENT)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 101.74 396.976 cm 0 0 m 0 -45.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 24.36 350.8662 cm 0 0 m 69.679 0 l S Q /Span <>BDC BT /GS0 gs 0 Tc 0 Tw 11 0 0 11 24.36 388.0317 Tm (Follicular)Tj ET EMC /Span <>BDC BT 11 0 0 11 24.36 376.0317 Tm (neoplasm)Tj ET EMC /Span <>BDC BT 9 0 0 9 75.7077 380.0317 Tm (a )Tj ET EMC /Span <>BDC BT 11 0 0 11 24.36 364.0317 Tm (\(Bethesda IV\))Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 24.36 352.0317 Tm (\()Tj ET EMC /Span <>BDC BT 11 0 0 11 28.0231 352.0317 Tm (See THYR-3\))Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS0 gs q 1 0 0 1 103.8389 374.0359 cm 0 0 m 12.379 0 l S Q 0 0 0 scn q 1 0 0 1 121.68 374.0359 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 124.56 309.0957 cm 0 0 m 0 129.88 l S Q q 1 0 0 1 289.4697 438.976 cm 0 0 m 0 -129.88 l S Q /Span <>BDC BT 11 0 0 11 126.72 430.0317 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 133.6272 430.0317 Tm (Thyroid and neck ultrasound )Tj ET EMC /Span <>BDC BT 11 0 0 11 133.92 418.0317 Tm (\(including central and )Tj ET EMC /Span <>BDC BT 11 0 0 11 133.92 406.0317 Tm (lateral compartments\), if not )Tj ET EMC /Span <>BDC BT 11 0 0 11 133.92 394.0317 Tm (previously done)Tj ET EMC /Span <>BDC BT 11 0 0 11 126.72 382.0317 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 133.6272 382.0317 Tm (CT/MRI with contrast for )Tj ET EMC /Span <>BDC BT 11 0 0 11 133.92 370.0317 Tm (locally advanced disease or )Tj ET EMC /Span <>BDC BT 11 0 0 11 133.92 358.0317 Tm (vocal cord paresis)Tj ET EMC /Span <>BDC BT 9 0 0 9 230.5245 362.0317 Tm (b)Tj ET EMC /Span <>BDC BT 11 0 0 11 236.022 358.0317 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 126.72 346.0317 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 133.6272 346.0317 Tm (Consider evaluation of vocal )Tj ET EMC /Span <>BDC BT 11 0 0 11 133.92 334.0317 Tm (cord mobility \(ultrasound, )Tj ET EMC /Span <>BDC BT 11 0 0 11 133.92 322.0317 Tm [(mirror indirect laryngoscopy)74.5 (, )]TJ ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 133.92 310.0317 Tm <00520055000300bf004500480055005200530057004c00460003004f00440055005c0051004a00520056004600520053005c000c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 276.3292 314.0317 Tm (c)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 291.76 374.0359 cm 0 0 m 14.698 0 l S Q q 1 0 0 1 311.92 374.0359 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 314.9 485.92 cm 0 0 m 0 -223.768 l S Q EMC 10 M q 1 0 0 1 469.8137 486.856 cm 0 0 m 0 -93.88 l S Q /Span <>BDC BT 11 0 0 11 317.4 477.9117 Tm [(T)74.4 (otal thyroidectomy if )]TJ ET EMC /Span <>BDC BT 11 0 0 11 317.4 465.9117 Tm [(invasive cancer)54.5 (, metastatic )]TJ ET EMC /Span <>BDC BT -0.004 Tw 11 0 0 11 317.4 453.9117 Tm [(cancer)54.6 (, )0.6 (or )0.5 (patient )0.7 (prefere)-0.7 (nce)]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 317.4 441.9117 Tm (Perform therapeutic neck )Tj ET EMC /Span <>BDC BT 11 0 0 11 317.4 429.9117 Tm (dissection of involved )Tj ET EMC /Span <>BDC BT 11 0 0 11 317.4 417.9117 Tm (compartments for clinically )Tj ET EMC /Span <>BDC BT 11 0 0 11 317.4 405.9117 Tm (apparent/biopsy-proven )Tj ET EMC /Span <>BDC BT 11 0 0 11 317.4 393.9117 Tm (disease)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 487.479 411.37 cm 0 0 m -15.768 28.546 l -0.059 57.088 l S Q q 1 0 0 1 490.12 406.5887 cm 0 0 m -1.157 7.372 l -5.624 4.904 l h f Q q 1 0 0 1 490.0536 473.243 cm 0 0 m -5.617 -4.913 l -1.146 -7.374 l h f Q q 1 0 0 1 471.571 439.9072 cm 0 0 m 9.408 0 l S Q q 1 0 0 1 486.441 439.9072 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 491.96 470.6657 cm 0 0 m 0 33.88 l S Q q 1 0 0 1 548.48 504.546 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 11 0 0 11 494.12 495.6017 Tm (Benign )Tj ET EMC /Span <>BDC BT 11 0 0 11 494.12 483.6017 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 494.12 471.6017 Tm (NIFTP)Tj ET EMC /Span <>BDC BT 9 0 0 9 525.8954 475.6017 Tm (e)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 551 487.6059 cm 0 0 m 129.418 0 l S Q q 1 0 0 1 685.88 487.6059 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 690.816 464.6656 cm 0 0 m 0 45.88 l S Q /Span <>BDC BT 11 0 0 11 692.976 501.6017 Tm (Levothyroxine )Tj ET EMC /Span <>BDC BT 11 0 0 11 692.976 489.6017 Tm (therapy to )Tj ET EMC /Span <>BDC BT 11 0 0 11 692.976 477.6017 Tm (keep TSH )Tj ET EMC /Span <>BDC BT 11 0 0 11 692.976 465.6017 Tm (normal)Tj ET EMC /Span <>BDC BT 9 0 0 9 729.6498 469.6017 Tm (f)Tj ET EMC /Span <>BDC BT 11 0 0 11 494.12 435.9117 Tm (Papillary carcinoma)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 605.96 439.9158 cm 0 0 m 74.458 0 l S Q q 1 0 0 1 685.88 439.9158 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 494.12 405.1403 Tm (Follicular)Tj ET EMC /Span <>BDC BT 11 0 0 11 494.12 393.1403 Tm (carcinoma)Tj ET EMC /Artifact <>BDC q 1 0 0 1 555.7 403.1446 cm 0 0 m 132.718 0 l S Q q 1 0 0 1 693.88 403.1446 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 692.976 434.7462 cm 0 0 m 54.21 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 692.976 435.9117 Tm [(See P)74.1 (AP-4)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 317.4 332.2194 Tm (or)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 694.976 414.1487 cm 0 0 m 0 -108.149 l S Q EMC 10 M q 1 0 0 1 491.96 328.1554 cm 0 0 m 0 57.88 l S Q q 1 0 0 1 580.7217 386.0357 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT 11 0 0 11 494.12 377.0914 Tm (Invasive cancer )Tj ET EMC /Span <>BDC BT 11 0 0 11 494.12 365.0914 Tm (\(widely invasive )Tj ET EMC /Span <>BDC BT 11 0 0 11 494.12 353.0914 Tm (or encapsulated )Tj ET EMC /Span <>BDC BT 11 0 0 11 494.12 341.0914 Tm (angioinvasive )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 494.12 329.0914 Tm <005a004c0057004b000300950017000300590048005600560048004f0056000c0003>Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 584.6587 357.0955 cm 0 0 m 8.479 0 l S Q q 1 0 0 1 598.6 357.0955 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 599.44 359.0914 Tm (Completion of )Tj ET EMC /Span <>BDC BT 11 0 0 11 599.44 347.0914 Tm (thyroidectomy)Tj ET EMC /Artifact <>BDC q 1 0 0 1 679.9387 357.0955 cm 0 0 m 8.479 0 l S Q q 1 0 0 1 693.88 357.0955 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 697.976 336.9046 cm 0 0 m 45.821 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 697.976 374.0702 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 697.976 362.0702 Tm (Postsurgical )Tj ET EMC /Span <>BDC BT 11 0 0 11 697.976 350.0702 Tm (Evaluation )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 697.976 338.0702 Tm (\(FOLL-2\))Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 491.96 231.9739 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 580.4949 301.8542 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT 0 0 0 scn 11 0 0 11 494.12 292.9099 Tm (Encapsulated )Tj ET EMC /Span <>BDC BT 11 0 0 11 494.12 280.9099 Tm (angioinvasive )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 494.12 268.9099 Tm <005a004c0057004b0003001f0017000300590048005600560048004f0056>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 574.5306 268.9099 Tm (\) )Tj ET EMC 1.155 w q 1 0 0 1 574.5306 272.5766 cm 0 0 m 3.734 0 l S Q /Span <>BDC BT 11 0 0 11 494.12 256.9099 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 494.12 244.9099 Tm (Minimally )Tj ET EMC /Span <>BDC BT 11 0 0 11 494.12 232.9099 Tm (invasive FTC)Tj ET EMC /Span <>BDC BT 9 0 0 9 561.9784 236.9099 Tm (d)Tj ET EMC /Artifact <>BDC 1 w 4 M q 1 0 0 1 581.8817 271.08 cm 0 0 m 11.256 0 l S Q q 1 0 0 1 598.6 271.08 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 600.1601 246.6491 cm 0 0 m 0 81.88 l S Q /Span <>BDC BT 11 0 0 11 602.3201 319.5851 Tm (Completion of)Tj ET EMC /Span <>BDC BT 11 0 0 11 602.3201 307.5851 Tm (thyroidectomy )Tj ET EMC /Span <>BDC BT 11 0 0 11 602.3201 283.5851 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 602.3201 259.5851 Tm (Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 602.3201 247.5851 Tm (monitoring)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 679.447 317.2654 cm 0 0 m 8.971 0 l S Q q 1 0 0 1 693.88 317.2654 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 664.5779 255.6883 cm 0 0 m 23.84 0 l S Q q 1 0 0 1 693.88 255.6883 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 695.816 176.0019 cm 0 0 m 0 117.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 704.8832 223.7724 cm 0 0 m 67.273 0 l S Q q 1 0 0 1 705.176 211.7724 cm 0 0 m 59.872 0 l S Q q 1 0 0 1 705.176 199.7724 cm 0 0 m 22.612 0 l S Q q 1 0 0 1 705.176 187.7724 cm 0 0 m 69.685 0 l S Q q 1 0 0 1 705.176 175.7724 cm 0 0 m 45.821 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 697.976 284.9379 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 704.8832 284.9379 Tm (Consider )Tj ET EMC /Span <>BDC BT 11 0 0 11 705.176 272.9379 Tm (levothyroxine )Tj ET EMC /Span <>BDC BT 11 0 0 11 705.176 260.9379 Tm (therapy to )Tj ET EMC /Span <>BDC BT 11 0 0 11 705.176 248.9379 Tm (keep TSH low )Tj ET EMC /Span <>BDC BT 11 0 0 11 705.176 236.9379 Tm (or normal)Tj ET EMC /Span <>BDC BT 9 0 0 9 755.906 240.9379 Tm (f)Tj ET EMC /Span <>BDC BT 11 0 0 11 697.976 224.9379 Tm <9520>Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 704.8832 224.9379 Tm (See Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 705.176 212.9379 Tm (Monitoring )Tj ET EMC /Span <>BDC BT 11 0 0 11 705.176 200.9379 Tm (and )Tj ET EMC /Span <>BDC BT 11 0 0 11 705.176 188.9379 Tm (Maintenance )Tj ET EMC /Span <>BDC BT 11 0 0 11 705.176 176.9379 Tm (\(FOLL-6\))Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 494.96 174.8998 cm 0 0 m 0 33.88 l S Q q 1 0 0 1 555.8669 208.7802 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 0 0 0 scn 11 0 0 11 497.12 199.8358 Tm (Benign)Tj ET EMC /Span <>BDC BT 11 0 0 11 497.12 187.8358 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 497.12 175.8358 Tm (NIFTP)Tj ET EMC /Span <>BDC BT 9 0 0 9 528.8954 179.8358 Tm (e)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 557.96 191.84 cm 0 0 m 33.418 0 l S Q q 1 0 0 1 596.84 191.84 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 602.44 193.8358 Tm (Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 602.44 181.8358 Tm (monitoring)Tj ET EMC /Span <>BDC BT 11 0 0 11 494.12 136.8308 Tm (Papillary )Tj ET EMC /Span <>BDC BT 11 0 0 11 494.12 124.8308 Tm (carcinoma)Tj ET EMC /Artifact <>BDC q 1 0 0 1 560.84 134.835 cm 0 0 m 33.418 0 l S Q q 1 0 0 1 599.72 134.835 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 604.6875 129.6653 cm 0 0 m 54.21 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 604.6875 130.8309 Tm [(See P)74.1 (AP-)]TJ ET EMC /Span <>BDC BT 11 0 0 11 652.7803 130.8309 Tm (3)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 317.4 267.0758 Tm (Lobectomy/isthmusectomy)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 670.88 191.84 cm 0 0 m 17.538 0 l S Q q 1 0 0 1 693.88 191.84 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 465.6268 270.5403 cm 0 0 m 12.025 0 l S Q q 1 0 0 1 483.1136 270.5403 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q q 1 0 0 1 466.0967 270.663 cm 0 0 m 24.626 -67.659 l S Q q 1 0 0 1 492.5908 197.8709 cm 0 0 m -0 7.462 l -4.796 5.717 l h f Q q 1 0 0 1 466.1176 270.2772 cm 0 0 m 23.745 -122.156 l S Q q 1 0 0 1 490.9045 142.7596 cm 0 0 m 1.167 7.37 l -3.843 6.397 l h f Q q 1 0 0 1 466.0967 270.1595 cm 0 0 m 20.61 56.626 l S Q q 1 0 0 1 488.575 331.9182 cm 0 0 m -0.001 -7.462 l -4.796 -5.717 l h f Q EMC endstream endobj 339 0 obj 22174 endobj %% Contents for page 23 %% Original object ID: 47 0 340 0 obj << /Length 341 0 R >> stream Q q BT /Xi21 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 341 0 obj 245 endobj %% Original object ID: 361 0 342 0 obj [ 2301 0 R 2302 0 R 2303 0 R 2304 0 R 2305 0 R 2306 0 R 2307 0 R 2308 0 R 2309 0 R 2310 0 R 2311 0 R 2312 0 R ] endobj %% Contents for page 24 %% Original object ID: 48 0 343 0 obj << /Length 344 0 R >> stream q endstream endobj 344 0 obj 2 endobj %% Contents for page 24 %% Original object ID: 362 0 345 0 obj << /Length 346 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Follicular Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 728.6078 23.544 Tm [(FOLL)17.6 (-)35 (2)]TJ ET EMC /Span <>BDC BT -0.104 Tw 11 0 0 11 23.7374 514.3517 Tm [(POSTSURGICAL)35.7 ( EV)74 (ALUA)73.9 (TION)17.3 ( )]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 495.3358 Tm (No gross residual disease in neck)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 207 499.34 cm 0 0 m 201.578 0 l S Q q 1 0 0 1 414.0405 499.34 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 416.5463 481.1949 cm 0 0 m 0 21.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 500.6101 480.9653 cm 0 0 m 45.821 0 l S Q /Span <>BDC BT /GS0 gs -0.002 Tw 11 0 0 11 418.7063 494.1309 Tm [(See Consideration for Initial )0.8 (Postoperative RAI Therapy )37.1 (After T)74.4 (otal )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 418.7063 482.1309 Tm (Thyroidectomy )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 500.6101 482.1309 Tm (\(FOLL-3)Tj ET EMC /Span <>BDC BT 11 0 0 11 542.7678 482.1309 Tm (\))Tj ET EMC q 1 0 0 1 29.304 96.3276 cm 0 0 m 202.666 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 8 0 0 8 23.544 100.3872 Tm (f)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.304 97.3872 Tm [(See Principle)-0.8 (s of )18.2 (TSH Suppression \(THYR-A\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 231.97 97.3872 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 89.3872 Tm (g)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 86.3872 Tm [(For bulky)74.2 (, locoregional, visc)-1 (erally invasive disease or rap)-1.9 (id progression, refer to )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 75.3872 Tm (high)Tj /Span<>> BDC (-)Tj EMC (volume multidisciplinary institution, including radiation oncology referral.) Tj ET EMC /GS1 gs q 1 0 0 1 406.1514 96.3276 cm 0 0 m 245.474 0 l S Q /Span <>BDC BT /GS0 gs 8 0 0 8 400.3914 100.3872 Tm (h)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 406.1514 97.3872 Tm (See )Tj ET EMC /Span <>BDC BT 10 0 0 10 426.7227 97.3872 Tm [(Principle)-0.8 (s of Radiation )-0.7 (and RAI )18.1 (Therapy \(THYR)]TJ /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 651.625 97.3872 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 400.3914 89.3872 Tm (i)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 406.1514 86.3872 Tm [(If considering)-0.7 ( dosimetry iodi)-0.8 (ne)]TJ /Span<>> BDC (-)Tj EMC [(131 is the preferred agent)-1.3 (.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 400.3914 78.3872 Tm (j)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 406.1514 75.3872 Tm [(For contraindications to withdrawal, thyrotropin alfa may b)-1.1 (e used.)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 68.1445 423.7917 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.544 414.8474 Tm (Gross )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 402.8474 Tm (residual )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 390.8474 Tm (disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 378.8474 Tm (in neck)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 166.4944 366.2518 cm 0 0 m -14.598 34.6 l -0.15 69.192 l S Q q 1 0 0 1 168.6177 361.2192 cm 0 0 m -0.375 7.453 l -5.077 5.469 l h f Q q 1 0 0 1 168.4491 440.4838 cm 0 0 m -5.057 -5.487 l -0.348 -7.454 l h f Q EMC /Span <>BDC BT 11 0 0 11 136.1 455.3159 Tm (Resectable)Tj ET EMC /Span <>BDC BT 11 0 0 11 136.1 338.2389 Tm (Unresectable)Tj ET EMC /Span <>BDC BT 9 0 0 9 205.1884 342.2389 Tm (g)Tj ET EMC /Artifact <>BDC q 1 0 0 1 200.8667 459.32 cm 0 0 m 12.178 0 l S Q q 1 0 0 1 218.5067 459.32 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 219.5067 461.3159 Tm (Resect, if)Tj ET EMC /Span <>BDC BT 11 0 0 11 219.5067 449.3159 Tm (possible)Tj ET EMC /Artifact <>BDC q 1 0 0 1 283.7047 449.4893 cm 0 0 m -9.897 9.831 l -0.119 19.642 l S Q q 1 0 0 1 287.58 445.64 cm 0 0 m -3.177 6.752 l -6.773 3.131 l h f Q q 1 0 0 1 287.4411 472.9999 cm 0 0 m -6.757 -3.166 l -3.143 -6.768 l h f Q EMC /Span <>BDC BT 11 0 0 11 290.58 487.8963 Tm (No gross )Tj ET EMC /Span <>BDC BT 11 0 0 11 290.58 475.8963 Tm (residual disease)Tj ET EMC /Artifact <>BDC q 1 0 0 1 376.78 485.9005 cm 0 0 m 31.798 0 l S Q q 1 0 0 1 414.0406 485.9005 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 290.58 434.4963 Tm (Gross residual )Tj ET EMC /Span <>BDC BT 11 0 0 11 290.58 422.4963 Tm (disease)Tj ET EMC /Artifact <>BDC q 1 0 0 1 328.3282 420.1899 cm 0 0 m 0 -13.428 l S Q q 1 0 0 1 328.3282 401.2997 cm 0 0 m 2.552 7.012 l -2.552 7.012 l h f Q EMC 10 M q 1 0 0 1 233.0336 283.3029 cm 0 0 m 0 117.88 l S Q q 1 0 0 1 372.093 401.1833 cm 0 0 m 0 -117.88 l S Q /Span <>BDC BT 11 0 0 11 235.1936 392.239 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 242.1008 392.239 Tm (TSH + Tg measurement )Tj ET EMC /Span <>BDC BT 11 0 0 11 367.2984 392.239 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 380.239 Tm (+ antithyroglobulin )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 368.239 Tm (antibodies \(6\22612 wks )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 356.239 Tm (postoperatively\))Tj ET EMC /Span <>BDC BT 11 0 0 11 235.1936 344.239 Tm <9520>Tj ET EMC /Span <>BDC BT -0.027 Tw 11 0 0 11 242.1008 344.239 Tm (Iodine)Tj /Span<>> BDC (-)Tj EMC (123 or iodine)Tj /Span<>> BDC (-)Tj EMC (131)Tj ET EMC /Span <>BDC BT 0 Tw 9 0 0 9 367.4325 348.239 Tm (i )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 332.239 Tm (total body radioiodine )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 320.239 Tm (imaging with TSH )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 308.239 Tm (stimulation \(thyroid )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 296.239 Tm (hormone withdrawal)Tj ET EMC /Span <>BDC BT 9 0 0 9 349.3482 300.239 Tm (j)Tj ET EMC /Span <>BDC BT 11 0 0 11 351.8487 296.239 Tm (\) )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 284.239 Tm (\(category 2B\))Tj ET EMC q 1 0 0 1 386.98 390.1219 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 453.86 436.0022 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 11 0 0 11 389.14 427.0579 Tm (Suspected )Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 415.0579 Tm (or proven )Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 403.0579 Tm (inadequate )Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 391.0579 Tm (RAI uptake)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 454.7145 413.0621 cm 0 0 m 3.503 0 l S Q q 1 0 0 1 463.68 413.0621 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 463.54 395.1219 cm 0 0 m 0 57.88 l S Q /Span <>BDC BT -0.002 Tw 11 0 0 11 465.7 444.0579 Tm [(Monitoring )1.1 (of residual disease)]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 465.7 432.0579 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 420.0579 Tm (Consider EBRT/IMRT if )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 408.0579 Tm (disease is threatening vital )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 396.0579 Tm (structures)Tj ET EMC /Span <>BDC BT 9 0 0 9 519.4969 400.0579 Tm (h)Tj ET EMC q 1 0 0 1 386.98 284.1316 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 449.02 354.0119 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT 11 0 0 11 389.14 345.0676 Tm (Adequate )Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 333.0676 Tm (RAI uptake)Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 321.0676 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 309.0676 Tm (No RAI )Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 297.0676 Tm (imaging )Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 285.0676 Tm (performed)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 449.568 319.0718 cm 0 0 m 7.786 0 l S Q q 1 0 0 1 462.816 319.0718 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 463.54 290.1316 cm 0 0 m 0 57.88 l S Q /Span <>BDC BT 11 0 0 11 465.7 339.0676 Tm <9520>Tj ET EMC /Span <>BDC BT -0.025 Tw 11 0 0 11 472.6072 339.0676 Tm [(Radioiodine )1.1 (treatment \(preferred\))]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 465.7 327.0676 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 472.6072 327.0676 Tm (Post-treatment iodine)Tj /Span<>> BDC (-)Tj EMC (131 whole )Tj ET EMC /Span <>BDC BT 11 0 0 11 472.9 315.0676 Tm (body imaging)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 303.0676 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 472.6072 303.0676 Tm (TSH)Tj /Span<>> BDC (-)Tj EMC (stimulated Tg)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 291.0676 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 472.6072 291.0676 Tm (Consider EBRT/IMRT)Tj ET EMC /Span <>BDC BT 9 0 0 9 583.2195 295.0676 Tm (h)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 649.734 452.0662 cm 0 0 m 0 -339.703 l S Q EMC 10 M q 1 0 0 1 82.9944 371.9113 cm 0 0 m 0 57.88 l S Q q 1 0 0 1 151.2539 429.7917 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT 11 0 0 11 85.1544 420.8474 Tm (Cross)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 85.1544 408.8474 Tm (sectional )Tj ET EMC /Span <>BDC BT 11 0 0 11 85.1544 396.8474 Tm (CT or MRI )Tj ET EMC /Span <>BDC BT 11 0 0 11 85.1544 384.8474 Tm (of neck with )Tj ET EMC /Span <>BDC BT 11 0 0 11 85.1544 372.8474 Tm (contrast)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 68.9821 400.8515 cm 0 0 m 6.416 0 l S Q q 1 0 0 1 80.86 400.8515 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 133.94 157.9217 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 238.6992 227.802 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT 11 0 0 11 136.1 218.8577 Tm (For viscerally )Tj ET EMC /Span <>BDC BT -0.021 Tw 11 0 0 11 136.1 206.8577 Tm (invasive disease or )Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 136.1 194.8577 Tm (rapid progression, )Tj ET EMC /Span <>BDC BT 11 0 0 11 136.1 182.8577 Tm (upfront EBRT/)Tj ET EMC /Span <>BDC BT 11 0 0 11 136.1 170.8577 Tm (IMRT may be most )Tj ET EMC /Span <>BDC BT 11 0 0 11 136.1 158.8577 Tm (appropriate)Tj ET EMC /Span <>BDC BT 9 0 0 9 196.6107 162.8577 Tm (h)Tj ET EMC q 1 0 0 1 260.0336 145.9218 cm 0 0 m 0 93.88 l S Q q 1 0 0 1 428.3356 239.802 cm 0 0 m 0 -93.88 l S Q /Span <>BDC BT 11 0 0 11 262.1936 230.8577 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 269.1008 230.8577 Tm (TSH + Tg measurement )Tj ET EMC /Span <>BDC BT 11 0 0 11 394.7199 230.8577 Tm ( )Tj ET EMC /Span <>BDC BT -0.026 Tw 11 0 0 11 269.3936 218.8577 Tm [(+ )0.6 (antithyroglobulin )1.5 (antibodies )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 269.3936 206.8577 Tm (\(6\22612 wks postoperatively\))Tj ET EMC /Span <>BDC BT 11 0 0 11 262.1936 194.8577 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 269.1008 194.8577 Tm (Iodine)Tj /Span<>> BDC (-)Tj EMC (123 or iodine)Tj /Span<>> BDC (-)Tj EMC (131)Tj ET EMC /Span <>BDC BT 9 0 0 9 395.0207 198.8577 Tm (i )Tj ET EMC /Span <>BDC BT 11 0 0 11 400.0217 194.8577 Tm (total )Tj ET EMC /Span <>BDC BT 11 0 0 11 269.3936 182.8577 Tm (body radioiodine imaging )Tj ET EMC /Span <>BDC BT 11 0 0 11 269.3936 170.8577 Tm (with TSH stimulation \(thyroid )Tj ET EMC /Span <>BDC BT 11 0 0 11 269.3936 158.8577 Tm (hormone withdrawal)Tj ET EMC /Span <>BDC BT 9 0 0 9 376.3481 162.8577 Tm (j)Tj ET EMC /Span <>BDC BT 11 0 0 11 378.8486 158.8577 Tm (\) )Tj ET EMC /Span <>BDC BT 11 0 0 11 269.3936 146.8577 Tm (\(category 2B\))Tj ET EMC q 1 0 0 1 463.54 218.5079 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 526.6968 264.3882 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 11 0 0 11 465.7 255.4439 Tm (Suspected )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 243.4439 Tm (or proven )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 231.4439 Tm (inadequate )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 219.4439 Tm (RAI uptake)Tj ET EMC q 1 0 0 1 463.54 117.4269 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 525.58 187.3072 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT 11 0 0 11 465.7 178.3629 Tm (Adequate )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 166.3629 Tm (RAI uptake)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 154.3629 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 142.3629 Tm (No RAI )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 130.3629 Tm (imaging )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 118.3629 Tm (performed)Tj ET EMC q 1 0 0 1 542.7543 206.5079 cm 0 0 m 0 69.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 548.5773 206.2784 cm 0 0 m 38.495 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 544.9142 267.4439 Tm (Monitoring of )Tj ET EMC /Span <>BDC BT 11 0 0 11 544.9142 255.4439 Tm (residual disease)Tj ET EMC /Span <>BDC BT 11 0 0 11 630.5187 255.4439 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 544.9142 243.4439 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 544.9142 231.4439 Tm (Consider )Tj ET EMC /Span <>BDC BT 11 0 0 11 544.9142 219.4439 Tm (systemic therapy )Tj ET EMC /Span <>BDC BT 11 0 0 11 544.9142 207.4439 Tm (\()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 548.5773 207.4439 Tm (FOLL)Tj /Span<>> BDC (-)Tj EMC (8)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 587.072 207.4439 Tm (\))Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 542.7542 111.4269 cm 0 0 m 0 81.88 l S Q /Span <>BDC BT 11 0 0 11 544.9142 184.3629 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 551.8214 184.3629 Tm (Radioiodine )Tj ET EMC /Span <>BDC BT 11 0 0 11 552.1142 172.3629 Tm (treatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 552.1142 160.3629 Tm (\(preferred\))Tj ET EMC /Span <>BDC BT 9 0 0 9 607.7372 164.3629 Tm (h)Tj ET EMC /Span <>BDC BT 11 0 0 11 544.9142 148.3629 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 551.8214 148.3629 Tm (Post-treatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 552.1142 136.3629 Tm (iodine)Tj /Span<>> BDC (-)Tj EMC (131 whole )Tj ET EMC /Span <>BDC BT 11 0 0 11 552.1142 124.3629 Tm (body imaging)Tj ET EMC /Span <>BDC BT -0.002 Tc 0.002 Tw 11 0 0 11 544.9142 112.3629 Tm <9520>Tj ET EMC /Span <>BDC BT -0.011 Tw 11 0 0 11 551.7774 112.3629 Tm (TSH)Tj /Span<>> BDC (-)Tj EMC (stimulated Tg)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 527.349 152.3671 cm 0 0 m 9.493 0 l S Q q 1 0 0 1 542.304 152.3671 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 241.0537 192.8619 cm 0 0 m 12.178 0 l S Q q 1 0 0 1 258.6937 192.8619 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 527.349 241.4481 cm 0 0 m 9.493 0 l S Q q 1 0 0 1 542.304 241.4481 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 174.2401 333.5201 cm 0 0 m 0 -96.162 l S Q q 1 0 0 1 174.2401 231.8964 cm 0 0 m 2.552 7.012 l -2.552 7.012 l h f Q EMC /Artifact <>BDC q 1 0 0 1 211.0736 342.2431 cm 0 0 m 13.108 0 l S Q q 1 0 0 1 229.6433 342.2431 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 382.8782 360.8738 cm 0 0 m -10.447 12.437 l -0.12 24.856 l S Q q 1 0 0 1 386.3914 356.6913 cm 0 0 m -2.556 7.011 l -6.464 3.728 l h f Q q 1 0 0 1 386.2506 389.93 cm 0 0 m -6.445 -3.76 l -2.521 -7.023 l h f Q EMC /Artifact <>BDC q 1 0 0 1 455.5942 163.9936 cm 0 0 m -25.336 28.868 l -0.271 57.719 l S Q q 1 0 0 1 459.1972 159.8882 cm 0 0 m -2.708 6.954 l -6.543 3.587 l h f Q q 1 0 0 1 458.9054 225.8355 cm 0 0 m -6.525 -3.62 l -2.673 -6.967 l h f Q EMC 10 M q 1 0 0 1 669.4358 241.2744 cm 0 0 m 0 81.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 678.503 277.0449 cm 0 0 m 67.273 0 l S Q q 1 0 0 1 678.7958 265.0449 cm 0 0 m 82.484 0 l S Q q 1 0 0 1 678.7958 253.0449 cm 0 0 m 69.685 0 l S Q q 1 0 0 1 678.7958 241.0449 cm 0 0 m 45.821 0 l S Q /Span <>BDC BT /GS0 gs 0 Tc 0 Tw 11 0 0 11 671.5958 314.2104 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 678.503 314.2104 Tm (Suppress )Tj ET EMC /Span <>BDC BT 11 0 0 11 678.7958 302.2104 Tm (TSH with )Tj ET EMC /Span <>BDC BT 11 0 0 11 678.7958 290.2104 Tm (levothyroxine)Tj ET EMC /Span <>BDC BT 9 0 0 9 750.3173 294.2104 Tm (f)Tj ET EMC /Span <>BDC BT 11 0 0 11 671.5958 278.2104 Tm <9520>Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 678.503 278.2104 Tm (See Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 678.7958 266.2104 Tm (Monitoring and )Tj ET EMC /Span <>BDC BT 11 0 0 11 678.7958 254.2104 Tm (Maintenance )Tj ET EMC /Span <>BDC BT 11 0 0 11 678.7958 242.2104 Tm (\(FOLL-6\))Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS0 gs q 1 0 0 1 648.4769 282.2147 cm 0 0 m 15.625 0 l S Q 0 0 0 scn q 1 0 0 1 669.5639 282.2147 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC endstream endobj 346 0 obj 22992 endobj %% Contents for page 24 %% Original object ID: 49 0 347 0 obj << /Length 348 0 R >> stream Q q BT /Xi22 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 348 0 obj 245 endobj %% Original object ID: 364 0 349 0 obj [ 2313 0 R 2314 0 R 2315 0 R 2316 0 R 2317 0 R 2318 0 R 2319 0 R 2320 0 R 2321 0 R 2322 0 R 2323 0 R ] endobj %% Contents for page 25 %% Original object ID: 50 0 350 0 obj << /Length 351 0 R >> stream q endstream endobj 351 0 obj 2 endobj %% Contents for page 25 %% Original object ID: 365 0 352 0 obj << /Length 353 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Follicular Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 728.6078 23.544 Tm [(FOLL)17.6 (-)35 (3)]TJ ET EMC /Span <>BDC BT -0.053 Tw 11 0 0 11 23.7374 513.8317 Tm [(CLINICOP)74.1 (A)73.9 (THOLOGIC)17.3 ( F)55.2 (ACT)18 (ORS)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 271.9994 500.6183 cm 0 0 m 0 -93.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 491.674 Tm (RAI not typically recommended \(if all present\):)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 479.674 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 479.674 Tm <002f00440055004a004800560057000300530055004c005000440055005c0003005700580050005200550003001f0015000300460050>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.544 467.674 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 467.674 Tm (Intrathyroidal)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 455.674 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 455.674 Tm (No vascular invasion)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 443.674 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 443.674 Tm (Clinical N0 )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 431.674 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 431.674 Tm (No detectable anti-Tg antibodies)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 419.674 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 419.674 Tm <0033005200560057005200530048005500440057004c0059004800030058005100560057004c00500058004f004400570048004700030037004a0003001f001400030051004a00120050002f>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 242.8458 423.674 Tm (k)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 407.674 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 407.674 Tm (Negative postoperative ultrasound, if done)Tj ET EMC /Span <>BDC BT 9 0 0 9 253.5396 411.674 Tm (l)Tj ET EMC 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 637.8109 442.5085 cm 0 0 m 128.992 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 634.1478 455.674 Tm (RAI not typically indicated)Tj ET EMC /Span <>BDC BT 11 0 0 11 771.6693 455.674 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 634.1478 443.674 Tm (\()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 637.8109 443.674 Tm (See Surveillance FOLL-6)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 766.803 443.674 Tm (\))Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 271.9994 384.9663 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT 11 0 0 11 23.544 376.022 Tm (RAI selectively recommended \(if any present\):)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 364.022 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 364.022 Tm (Largest primary tumor 2\2264 cm)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 352.022 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 352.022 Tm (Minor vascular invasion)Tj ET EMC /Span <>BDC BT 9 0 0 9 155.7696 356.022 Tm (d)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 340.022 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 340.022 Tm (Cervical lymph node metastases)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 328.022 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 328.022 Tm <0033005200560057005200530048005500440057004c0059004800030058005100560057004c00500058004f004400570048004700030037004a0003001f001800b10014001300030051004a00120050002f>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 261.1988 332.022 Tm (k)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 316.022 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 316.022 Tm (Microscopic positive margins)Tj ET EMC q 1 0 0 1 269.549 283.1167 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT 11 0 0 11 23.544 274.1724 Tm (RAI recommended \(if any present\):)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 262.1724 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 262.1724 Tm (Gross extrathyroidal extension)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 250.1724 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 250.1724 Tm <00330055004c005000440055005c000300570058005000520055000300210017000300460050>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.544 238.1724 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 238.1724 Tm (Extensive vascular invasion)Tj ET EMC /Span <>BDC BT 9 0 0 9 177.1949 242.1724 Tm (d)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 226.1724 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 226.1724 Tm <0033005200560057005200530048005500440057004c0059004800030058005100560057004c00500058004f004400570048004700030037004a00030021001800b10014001300030051004a0012002f>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 251.418 230.1724 Tm (k,m)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 214.1724 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 214.1724 Tm <00250058004f004e005c0003005200550003002100180003005300520056004c0057004c005900480003004f005c00500053004b000300510052004700480056>Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 274.16 350.0262 cm 0 0 m 12.038 0 l S Q q 1 0 0 1 291.66 350.0262 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.544 195.1517 Tm (Known or suspected distant metastases at presentation )Tj ET EMC /Artifact <>BDC q 1 0 0 1 324.72 199.1559 cm 0 0 m 294.498 0 l S Q q 1 0 0 1 624.6801 199.1559 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 634.1478 187.9862 cm 0 0 m 68.449 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 634.1478 201.1517 Tm (Amenable to RAI)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 634.1478 189.1517 Tm (\()Tj ET EMC /Span <>BDC BT 11 0 0 11 637.8109 189.1517 Tm (See FOLL-5)Tj ET EMC /Span <>BDC BT 11 0 0 11 698.9339 189.1517 Tm (\))Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS0 gs q 1 0 0 1 269.8394 248.6766 cm 0 0 m 349.378 0 l S Q 0 0 0 scn q 1 0 0 1 624.6801 248.6766 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 634.1478 291.5303 cm 0 0 m 59.904 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 634.1478 304.6959 Tm (RAI being considered, )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 634.1478 292.6959 Tm (s)Tj ET EMC /Span <>BDC BT 11 0 0 11 640.2654 292.6959 Tm (ee FOLL-4)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 0.035 Tc -0.017 Tw 11 0 0 11 297.5933 513.8317 Tm [(CONSIDERA)73.9 (TION)17.3 ( )0.6 (FOR)17.2 ( )0.6 (INITIAL)35.7 ( )0.6 (POST)18.1 (OPERA)73.9 (TIVE)17.4 ( )0.6 (USE)17.5 ( )0.6 (OF)17.6 ( )0.6 (RAI)17.6 ( )]TJ ET EMC /Span <>BDC BT 11 0 0 11 297.5933 501.8317 Tm [(AFTER)17.2 ( )0.6 (T)18.1 (OT)74.2 (AL)35.6 ( )0.7 (THYROIDECT)18.1 (OMY)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 171.0088 Tm (Gross residual disease not amenable to RAI therapy)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 300.24 175.0129 cm 0 0 m 318.978 0 l S Q q 1 0 0 1 624.6801 175.0129 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 634.1478 169.8432 cm 0 0 m 61.123 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 634.1478 171.0087 Tm (See FOLL-8)Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 295.24 309.0859 cm 0 0 m 0 81.88 l S Q q 1 0 0 1 567.6 390.9662 cm 0 0 m 0 -81.88 l S Q /Span <>BDC BT 0 0 0 scn 11 0 0 11 297.4 382.0219 Tm (RAI ablation is recommended when the )Tj ET EMC /Span <>BDC BT 11 0 0 11 297.4 370.0219 Tm (combination of individual clinical factors \(such as )Tj ET EMC /Span <>BDC BT 11 0 0 11 297.4 358.0219 Tm [(the size of the primary tumor)55.6 (, histology)75.2 (, degree )]TJ ET EMC /Span <>BDC BT 11 0 0 11 297.4 346.0219 Tm (of lymphatic invasion, lymph node metastases, )Tj ET EMC /Span <>BDC BT 11 0 0 11 297.4 334.0219 Tm (postoperative thyroglobulin, and age at diagnosis\) )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 297.4 322.0219 Tm <0053005500480047004c0046005700560003004400030056004c004a0051004c00bf004600440051005700030055004c0056004e00030052004900030055004800460058005500550048005100460048000f00030047004c005600570044005100570003>Tj ET EMC /Span <>BDC BT 11 0 0 11 297.4 310.0219 Tm <0050004800570044005600570044005600480056000f00030052005500030047004c00560048004400560048>Tj /Span<>> BDC <0010>Tj EMC [<0056005300480046004c00bf0046000300500052005500570044004f004c0057005c>72.9 <0011>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 8 0 0 8 23.7612 144.456 Tm (d)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 141.456 Tm [(Minimally inva)-0.6 (sive follicular )-0.9 (thyroid carcinoma \(FTC\) is ch)-0.8 (aracterized as an encapsulated tumor with microscopic )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 130.456 Tm (capsular invasion and without vascular invasion.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 122.456 Tm (k)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 119.456 Tm [(Tg values obtained 6\22612 we)-1.2 (eks after total thyroidectomy)74 (.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 111.456 Tm (l)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 108.456 Tm [(If preoperative imaging inco)-1.3 (mplete, consider postoperativ)-1.5 (e ultrasound including central and lateral neck components.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 100.456 Tm (m )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 32.6479 97.456 Tm [(Additional cross-sectional imaging \(CT)15.6 ( or MRI of the neck with contrast and chest CT)18.1 ( with contrast\) should be )]TJ ET EMC /Span <>BDC BT 10 0 0 10 32.6479 86.456 Tm (considered to rule out the presence of significant normal thyroid remnant or gross residual disease and to detect ) Tj ET EMC /Span <>BDC BT 10 0 0 10 32.6479 75.456 Tm (clinically significant distant metastases.)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 572.4 350.0262 cm 0 0 m 46.818 0 l S Q q 1 0 0 1 624.6801 350.0262 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 630.84 363 cm 0 0 m 0 -120.6 l S Q EMC /Artifact <>BDC q 1 0 0 1 274.16 453.6782 cm 0 0 m 350.718 0 l S Q q 1 0 0 1 630.34 453.6782 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 645.5215 106.6824 cm 0 0 m 119.055 0 l S Q q 1 0 0 1 559.72 94.6824 cm 0 0 m 168.706 0 l S Q q 1 0 0 1 559.72 82.6824 cm 0 0 m 48.877 0 l S Q /Span <>BDC BT /GS0 gs /TT1 1 Tf 11 0 0 11 559.72 119.848 Tm (For general principles related to RAI )Tj ET EMC /Span <>BDC BT -0.006 Tw 11 0 0 11 559.72 107.848 Tm [(therapy)73.9 (, see the )]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 645.5215 107.848 Tm (Principles of Radiation )Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 559.72 95.848 Tm (and Radioactive Iodine Therapy )Tj ET EMC /Span <>BDC BT 11 0 0 11 559.72 83.848 Tm (\(THYR)Tj /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC 0 0 0 SCN 1 w 4 M /GS0 gs 556.34 80.468 211.616 50.768 re S endstream endobj 353 0 obj 15145 endobj %% Contents for page 25 %% Original object ID: 51 0 354 0 obj << /Length 355 0 R >> stream Q q BT /Xi23 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 355 0 obj 245 endobj %% Original object ID: 367 0 356 0 obj [ 2324 0 R 2325 0 R 2326 0 R 2327 0 R 2328 0 R 2329 0 R 2330 0 R 2331 0 R 2332 0 R 2333 0 R ] endobj %% Contents for page 26 %% Original object ID: 52 0 357 0 obj << /Length 358 0 R >> stream q endstream endobj 358 0 obj 2 endobj %% Contents for page 26 %% Original object ID: 368 0 359 0 obj << /Length 360 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Follicular Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 728.6078 23.544 Tm [(FOLL)17.6 (-)35 (4)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 105.84 348.4527 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 339.5084 Tm (6\22612 weeks )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 327.5084 Tm (post-)Tj ET EMC /Span <>BDC BT 11 0 0 11 50.4263 327.5084 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 315.5084 Tm (thyroidectomy)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 107.6794 331.5125 cm 0 0 m 7.818 0 l S Q q 1 0 0 1 120.96 331.5125 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 125.24 284.5724 cm 0 0 m 0 93.88 l S Q q 1 0 0 1 229.0472 378.4527 cm 0 0 m 0 -93.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 127.4 284.3429 cm 0 0 m 68.449 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 127.4 369.5084 Tm (Clinicopathologic )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 127.4 357.5084 Tm [<00bf00510047004c0051004a00560003>66.1 <005300550052005000530057004c0051004a0003>]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 127.4 345.5084 Tm (consideration for )Tj ET EMC /Span <>BDC BT 11 0 0 11 127.4 333.5084 Tm (RAI, without gross )Tj ET EMC /Span <>BDC BT 11 0 0 11 127.4 321.5084 Tm (residual disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 127.4 309.5084 Tm (or known distant )Tj ET EMC /Span <>BDC BT 11 0 0 11 127.4 297.5084 Tm (metastasis)Tj ET EMC /Span <>BDC BT 11 0 0 11 184.2691 297.5084 Tm ( )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 127.4 285.5084 Tm (\()Tj ET EMC /Span <>BDC BT 11 0 0 11 131.0631 285.5084 Tm (See FOLL-3)Tj ET EMC /Span <>BDC BT 11 0 0 11 192.1861 285.5084 Tm (\))Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 672.0974 290.0769 cm 0 0 m 0 93.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 681.1646 373.8474 cm 0 0 m 67.273 0 l S Q q 1 0 0 1 681.4573 361.8474 cm 0 0 m 82.484 0 l S Q q 1 0 0 1 681.4573 349.8474 cm 0 0 m 69.685 0 l S Q q 1 0 0 1 681.4573 337.8474 cm 0 0 m 45.821 0 l S Q q 1 0 0 1 685.1204 289.8474 cm 0 0 m 64.179 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 674.2573 375.0129 Tm <9520>Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 681.1646 375.0129 Tm (See Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 681.4573 363.0129 Tm (Monitoring and )Tj ET EMC /Span <>BDC BT 11 0 0 11 681.4573 351.0129 Tm (Maintenance )Tj ET EMC /Span <>BDC BT 11 0 0 11 681.4573 339.0129 Tm (\(FOLL-6\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 674.2573 327.0129 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 681.1646 327.0129 Tm (Levothyroxine )Tj ET EMC /Span <>BDC BT 11 0 0 11 681.4573 315.0129 Tm (to appropriate )Tj ET EMC /Span <>BDC BT 11 0 0 11 681.4573 303.0129 Tm (TSH target )Tj ET EMC /Span <>BDC BT 11 0 0 11 740.1312 303.0129 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 681.4573 291.0129 Tm (\()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 685.1204 291.0129 Tm (See THYR-A)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 749.2996 291.0129 Tm (\))Tj ET EMC /Span <>BDC BT 0.035 Tc -0.017 Tw 11 0 0 11 23.7373 514.3517 Tm [(RAI)17.5 ( )0.7 (BEING)17.6 ( )0.6 (CONSIDERED)17.2 ( )0.6 (BASED)17.3 ( )0.6 (ON)17.2 ( )0.6 (CLINICOP)74.1 (A)73.9 (THOLOGIC)17.2 ( )0.6 (FEA)73.9 (TURES)]TJ ET EMC /GS1 gs q 1 0 0 1 29.5212 173.3964 cm 0 0 m 245.474 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 0 Tc 0 Tw 8 0 0 8 23.7612 177.456 Tm (h)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 174.456 Tm (See )Tj ET EMC /Span <>BDC BT 10 0 0 10 50.0925 174.456 Tm [(Principle)-0.8 (s of Radiation )-0.7 (and RAI )18.1 (Therapy \(THYR)]TJ /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 274.9949 174.456 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 166.456 Tm (j)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 163.456 Tm [(For contraindications to withdrawal, thyrotropin alfa may b)-1.1 (e used.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 155.456 Tm (n)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 152.456 Tm (Even in the absence of thyroid bed uptake RAI treatment m)Tj (ay be considered. If higher than expected uptake \(residual thyroid uptake or distant metastasis\) change ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 141.456 Tm [(dose accordingly)72.8 (.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 133.456 Tm (o)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 130.456 Tm [(A)55.2 ( false)]TJ /Span<>> BDC (-)Tj EMC [(negative pretreatment scan is possible and should)-1.8 ( not prevent the use of RAI if otherwise indicated.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 122.456 Tm (p)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 119.456 Tm [(Alternatively)73.7 (, low-dose iodin)-1.3 (e)]TJ /Span<>> BDC (-)Tj EMC [(131 \(1\2263 mCi\) may be used)-1.4 (. )]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 111.456 Tm (q)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 108.456 Tm [(While pre-abl)-0.6 (ation diagnosti)-1 (c)( scans in this setting are commonly done at NCCN Member Institutions the panel recommends \(category 2B\) selective use of pre-ablation ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm [(diagnostic scans based on pathology)71.8 (, postoperative )17.7 (Tg, intraoperative findings, and available imaging studies. Furthermore, dosimetry studies are considered in ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 86.456 Tm (patients at high risk of having RAI-avid distant metastasis. Empiric RAI doses may exceed maximum tolerable activity levels in patients with decreased GFR. Dialysis ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 75.456 Tm (patients require special handling.)Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 333.6328 324.081 cm 0 0 m 0 105.88 l S Q q 1 0 0 1 428.9161 429.9613 cm 0 0 m 0 -105.88 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 335.7928 421.017 Tm (Consider )Tj ET EMC /Span <>BDC BT 11 0 0 11 335.7928 409.017 Tm (pretreatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 335.7928 397.017 Tm (whole body )Tj ET EMC /Span <>BDC BT 11 0 0 11 335.7928 385.017 Tm (diagnostic )Tj ET EMC /Span <>BDC BT 11 0 0 11 335.7928 373.017 Tm (imaging)Tj ET EMC /Span <>BDC BT 9 0 0 9 377.9613 377.017 Tm (n,o)Tj ET EMC /Span <>BDC BT 11 0 0 11 391.4569 373.017 Tm ( with )Tj ET EMC /Span <>BDC BT 11 0 0 11 335.7928 361.017 Tm (TSH stimulation )Tj ET EMC /Span <>BDC BT -0.008 Tw 11 0 0 11 335.7928 349.017 Tm (\(thyroid hormone )Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 335.7928 337.017 Tm (withdrawal)Tj ET EMC /Span <>BDC BT 9 0 0 9 392.6351 341.017 Tm (j,p,q)Tj ET EMC /Span <>BDC BT 11 0 0 11 411.1317 337.017 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 335.7928 325.017 Tm (\(category 2B\))Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 310.9565 377.0212 cm 0 0 m 15.178 0 l S Q q 1 0 0 1 331.5965 377.0212 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 451.5312 348.081 cm 0 0 m 0 57.88 l S Q q 1 0 0 1 544.4431 405.9613 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT 11 0 0 11 453.6913 397.017 Tm (Resect clinically )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 453.6913 385.017 Tm <0056004c004a0051004c00bf00460044005100570003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 453.6913 373.017 Tm (structural )Tj ET EMC /Span <>BDC BT 11 0 0 11 453.6913 361.017 Tm (disease if )Tj ET EMC /Span <>BDC BT 11 0 0 11 453.6913 349.017 Tm (possible )Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 430.9525 377.0212 cm 0 0 m 13.08 0 l S Q q 1 0 0 1 449.4949 377.0212 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 546.4794 377.0212 cm 0 0 m 8.978 0 l S Q q 1 0 0 1 560.9194 377.0212 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 242.84 354.081 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 308.9202 399.9613 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 11 0 0 11 245 391.017 Tm (RAI therapy )Tj ET EMC /Span <>BDC BT 11 0 0 11 245 379.017 Tm (indicated )Tj ET EMC /Span <>BDC BT 11 0 0 11 245 367.017 Tm (based on )Tj ET EMC /Span <>BDC BT 11 0 0 11 245 355.017 Tm (pathology)Tj ET EMC q 1 0 0 1 242.84 279.0901 cm 0 0 m 0 33.88 l S Q q 1 0 0 1 335.799 312.9704 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 11 0 0 11 245 304.0261 Tm (RAI therapy not )Tj ET EMC /Span <>BDC BT 11 0 0 11 245 292.0261 Tm (indicated based )Tj ET EMC /Span <>BDC BT 11 0 0 11 245 280.0261 Tm (on pathology)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 339.1779 296.0303 cm 0 0 m 323.938 0 l S Q q 1 0 0 1 668.5779 296.0303 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 562.9557 318.081 cm 0 0 m 0 117.88 l S Q q 1 0 0 1 651.7667 435.9613 cm 0 0 m 0 -117.88 l S Q /Span <>BDC BT 11 0 0 11 565.1157 427.017 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 572.0229 427.017 Tm (RAI therapy )Tj ET EMC /Span <>BDC BT 11 0 0 11 572.3157 415.017 Tm (for remnant )Tj ET EMC /Span <>BDC BT 11 0 0 11 572.3157 403.017 Tm (ablation or )Tj ET EMC /Span <>BDC BT 11 0 0 11 572.3157 391.017 Tm (adjuvant )Tj ET EMC /Span <>BDC BT 11 0 0 11 572.3157 379.017 Tm (therapy)Tj ET EMC /Span <>BDC BT 9 0 0 9 612.0511 383.017 Tm (h)Tj ET EMC /Span <>BDC BT 11 0 0 11 565.1157 367.017 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 572.0229 367.017 Tm (Post)Tj /Span<>> BDC (-)Tj EMC (treatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 572.3157 355.017 Tm (iodine)Tj /Span<>> BDC (-)Tj EMC (131 )Tj ET EMC /Span <>BDC BT 11 0 0 11 572.3157 343.017 Tm (imaging )Tj ET EMC /Span <>BDC BT 11 0 0 11 572.3157 331.017 Tm (\(whole body )Tj ET EMC /Span <>BDC BT 11 0 0 11 572.3157 319.017 Tm (RAI scan\))Tj ET EMC /Span <>BDC BT 9 0 0 9 623.0511 323.017 Tm (h)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 653.803 377.0212 cm 0 0 m 10.796 0 l S Q q 1 0 0 1 670.061 377.0212 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC /GS0 gs q 1 0 0 1 239.5324 316.45 cm 0 0 m -10.969 15.063 l -0.122 30.11 l S Q q 1 0 0 1 242.7478 312.0344 cm 0 0 m -2.065 7.171 l -6.191 4.167 l h f Q q 1 0 0 1 242.6047 350.9907 cm 0 0 m -6.171 -4.196 l -2.031 -7.181 l h f Q EMC endstream endobj 360 0 obj 14796 endobj %% Contents for page 26 %% Original object ID: 53 0 361 0 obj << /Length 362 0 R >> stream Q q BT /Xi24 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 362 0 obj 245 endobj %% Original object ID: 370 0 363 0 obj [ 2334 0 R 2335 0 R 2336 0 R 2337 0 R 2338 0 R 2339 0 R 2340 0 R 2341 0 R 2342 0 R 2343 0 R 2344 0 R ] endobj %% Contents for page 27 %% Original object ID: 54 0 364 0 obj << /Length 365 0 R >> stream q endstream endobj 365 0 obj 2 endobj %% Contents for page 27 %% Original object ID: 371 0 366 0 obj << /Length 367 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Follicular Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 728.6078 23.544 Tm [(FOLL)17.6 (-)35 (5)]TJ ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 23.738 514.2925 Tm [(KNOWN)17.2 ( )0.6 (OR)17.3 ( )0.6 (SUSPECTED)17.3 ( )0.6 (DIST)74.3 (ANT)17.6 ( )0.6 (MET)74.2 (AST)74.2 (A)73.9 (TIC)17.3 ( )0.6 (DISEASE)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 102.0342 376.1084 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.5446 367.1641 Tm (6\22612 weeks )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.5446 355.1641 Tm (post)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 23.5446 343.1641 Tm (thyroidectomy)Tj ET EMC q 1 0 0 1 119.7585 324.2281 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 196.4961 394.1084 cm 0 0 m 0 -69.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 121.9185 323.9985 cm 0 0 m 68.449 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 121.9185 385.1641 Tm (Known or )Tj ET EMC /Span <>BDC BT 11 0 0 11 121.9185 373.1641 Tm (suspected )Tj ET EMC /Span <>BDC BT 11 0 0 11 121.9185 361.1641 Tm (distant )Tj ET EMC /Span <>BDC BT -0.032 Tw 11 0 0 11 121.9185 349.1641 Tm [(metastases )-1.3 (at )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 121.9185 337.1641 Tm (presentation )Tj ET EMC /Span <>BDC BT 11 0 0 11 190.9854 337.1641 Tm ( )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 121.9185 325.1641 Tm (\()Tj ET EMC /Span <>BDC BT 11 0 0 11 125.5816 325.1641 Tm (See FOLL-3\))Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS0 gs q 1 0 0 1 102.9087 359.1683 cm 0 0 m 10.513 0 l S Q 0 0 0 scn q 1 0 0 1 118.884 359.1683 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 197.3706 359.1683 cm 0 0 m 9.658 0 l S Q q 1 0 0 1 212.4906 359.1683 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 213.365 300.2281 cm 0 0 m 0 117.88 l S Q q 1 0 0 1 331.0027 418.1084 cm 0 0 m 0 -117.88 l S Q /Span <>BDC BT 11 0 0 11 215.525 409.1641 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 222.4323 409.1641 Tm (Appropriate)Tj ET EMC /Span <>BDC BT 11 0 0 11 284.7692 409.1641 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 222.725 397.1641 Tm ( cross-sectional )Tj ET EMC /Span <>BDC BT 11 0 0 11 222.725 385.1641 Tm (imaging \(CT or MRI )Tj ET EMC /Span <>BDC BT 11 0 0 11 222.725 373.1641 Tm (with contrast\) of )Tj ET EMC /Span <>BDC BT 11 0 0 11 222.725 361.1641 Tm (known metastatic )Tj ET EMC /Span <>BDC BT 11 0 0 11 222.725 349.1641 Tm (foci)Tj ET EMC /Span <>BDC BT 9 0 0 9 242.2812 353.1641 Tm (r)Tj ET EMC /Span <>BDC BT 11 0 0 11 215.525 337.1641 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 222.4323 337.1641 Tm (Resect clinically )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 222.725 325.1641 Tm <0056004c004a0051004c00bf00460044005100570003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 222.725 313.1641 Tm (structural disease if )Tj ET EMC /Span <>BDC BT 11 0 0 11 222.725 301.1641 Tm (possible)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 331.8772 359.1683 cm 0 0 m 11.258 0 l S Q q 1 0 0 1 348.5972 359.1683 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 488.1364 414.2281 cm 0 0 m 0 81.88 l S Q q 1 0 0 1 555.7095 496.1084 cm 0 0 m 0 -81.88 l S Q /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 490.2964 487.1641 Tm <00260052005100bf00550050004800470003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 490.2964 475.1641 Tm (radioiodine)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 490.2964 463.1641 Tm (avid tumor)Tj ET EMC /Span <>BDC BT 11 0 0 11 490.2964 451.1641 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 490.2964 439.1641 Tm (Thyroid )Tj ET EMC /Span <>BDC BT 11 0 0 11 490.2964 427.1641 Tm (remnant )Tj ET EMC /Span <>BDC BT 11 0 0 11 490.2964 415.1641 Tm (uptake only)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 557.0029 455.1683 cm 0 0 m 9.658 0 l S Q q 1 0 0 1 572.1229 455.1683 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 680.1917 410.7765 cm 0 0 m 67.273 0 l S Q q 1 0 0 1 680.4844 398.7765 cm 0 0 m 82.484 0 l S Q q 1 0 0 1 680.4844 386.7765 cm 0 0 m 69.685 0 l S Q q 1 0 0 1 680.4844 374.7765 cm 0 0 m 45.821 0 l S Q q 1 0 0 1 739.1583 338.7765 cm 0 0 m 26.292 0 l S Q q 1 0 0 1 680.4844 326.7765 cm 0 0 m 45.214 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 673.2844 411.942 Tm <9520>Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 680.1917 411.942 Tm (See Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 680.4844 399.942 Tm (Monitoring and )Tj ET EMC /Span <>BDC BT 11 0 0 11 680.4844 387.942 Tm (Maintenance )Tj ET EMC /Span <>BDC BT 11 0 0 11 680.4844 375.942 Tm (\(FOLL-6\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 673.2844 363.942 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 680.1917 363.942 Tm (Levothyroxine )Tj ET EMC /Span <>BDC BT 11 0 0 11 680.4844 351.942 Tm (to appropriate )Tj ET EMC /Span <>BDC BT 11 0 0 11 680.4844 339.942 Tm (TSH target )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 739.1583 339.942 Tm (\()Tj ET EMC /Span <>BDC BT 11 0 0 11 742.8214 339.942 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 680.4844 327.942 Tm (THYR-A\))Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 575.0327 273.2198 cm 0 0 m 0 69.88 l S Q /Span <>BDC BT 0 0 0 scn 11 0 0 11 577.1926 334.1558 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 584.0999 334.1558 Tm (Consider )Tj ET EMC /Span <>BDC BT 11 0 0 11 584.3926 322.1558 Tm (RAI adjuvant )Tj ET EMC /Span <>BDC BT 11 0 0 11 584.3926 310.1558 Tm (therapy)Tj ET EMC /Span <>BDC BT 11 0 0 11 577.1926 298.1558 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 584.0999 298.1558 Tm (Post-treatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 584.3926 286.1558 Tm (imaging \(whole )Tj ET EMC /Span <>BDC BT 11 0 0 11 584.3926 274.1558 Tm (body RAI scan\))Tj ET EMC 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 29.5212 151.3964 cm 0 0 m 245.474 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 8 0 0 8 23.7612 155.456 Tm (h)Tj ET EMC /Span <>BDC BT /Span<>> BDC 8 0 0 8 28.2104 155.456 Tm ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 152.456 Tm (See )Tj ET EMC /Span <>BDC BT 10 0 0 10 50.0925 152.456 Tm [(Principl)-0.8 (es of Radiation )-0.7 (and RAI )18.4 (Therapy \(THYR)]TJ /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 274.9949 152.456 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 144.456 Tm (q)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 141.456 Tm [(While pre-abl)-0.6 (ation diagnosti)-1 (c)( scans in this setting are commonly done at NCCN Member Institutions the panel recommends \(category 2B\) selective use of pre-ablation ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 130.456 Tm [(diagnostic scans based on pathology)71.8 (, postoperative )17.7 (Tg, intraoperative findings, and available imaging studies. Furthermore, dosimetry studies are considered in ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 119.456 Tm (patients at high risk of having RAI-avid distant metastasis. Empiric RAI doses may exceed maximum tolerable activity levels in patients with decreased GFR. Dialysis ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 108.456 Tm (patients require special handling.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 100.456 Tm (r)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm [(T)111 (o evaluate macroscopic me)-0.7 (tastatic foci for potential alte)-0.7 (rative therapies \(such as surgical resection and/or external beam radiation\) to prevent invasion/compression ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 86.456 Tm [(of vital structures or pathologic fracture either as a result of disease progression or ) 15.5 (TSH stimulation.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 78.456 Tm (s)Tj ET EMC /Span <>BDC BT /Span<>> BDC 8 0 0 8 27.7612 78.456 Tm ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 75.456 Tm [(Thyrotropin alfa may be used for elderly patients for whom prolonged hypothyroidism may be risky) 71.2 (. )]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 573.4163 432.2281 cm 0 0 m 0 45.88 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 575.5763 469.1641 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 582.4835 469.1641 Tm (RAI therapy)Tj ET EMC /Span <>BDC BT 11 0 0 11 575.5763 457.1641 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 582.4835 457.1641 Tm (Post-treatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 582.7763 445.1641 Tm (imaging \(whole )Tj ET EMC /Span <>BDC BT 11 0 0 11 582.7763 433.1641 Tm (body RAI scan\))Tj ET EMC q 1 0 0 1 349.4716 294.2281 cm 0 0 m 0 129.88 l S Q q 1 0 0 1 476.6205 424.1084 cm 0 0 m 0 -129.88 l S Q /Span <>BDC BT 11 0 0 11 351.6316 415.1641 Tm (6 weeks following )Tj ET EMC /Span <>BDC BT 11 0 0 11 351.6316 403.1641 Tm (cross)Tj /Span<>> BDC (-)Tj EMC (sectional )Tj ET EMC /Span <>BDC BT 11 0 0 11 351.6316 391.1641 Tm (imaging:)Tj ET EMC /Span <>BDC BT 11 0 0 11 351.6316 379.1641 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 358.5388 379.1641 Tm (Consider 24)Tj /Span<>> BDC (-)Tj EMC (hour )Tj ET EMC /Span <>BDC BT 11 0 0 11 358.8316 367.1641 Tm (urine iodine)Tj ET EMC /Span <>BDC BT 11 0 0 11 351.6316 355.1641 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 358.5388 355.1641 Tm (Pretreatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 358.8316 343.1641 Tm (radioiodine )Tj ET EMC /Span <>BDC BT 11 0 0 11 358.8316 331.1641 Tm (diagnostic imaging )Tj ET EMC /Span <>BDC BT 11 0 0 11 358.8316 319.1641 Tm (\(iodine)Tj /Span<>> BDC (-)Tj EMC (123 or )Tj ET EMC /Span <>BDC BT 11 0 0 11 358.8316 307.1641 Tm (iodine)Tj /Span<>> BDC (-)Tj EMC (131\) with TSH )Tj ET EMC /Span <>BDC BT 11 0 0 11 358.8316 295.1641 Tm (stimulation)Tj ET EMC /Span <>BDC BT 9 0 0 9 417.5001 299.1641 Tm (h,q,s)Tj ET EMC /Span <>BDC BT 11 0 0 11 490.2963 298.1558 Tm (No uptake)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 493.4812 313.581 cm 0 0 m -15.459 45.587 l -0.158 91.169 l S Q q 1 0 0 1 495.2353 308.4081 cm 0 0 m 0.165 7.46 l -4.668 5.821 l h f Q q 1 0 0 1 495.0617 409.9282 cm 0 0 m -4.651 -5.836 l 0.188 -7.46 l h f Q EMC /Artifact <>BDC q 1 0 0 1 557.0029 302.16 cm 0 0 m 9.658 0 l S Q q 1 0 0 1 572.1229 302.16 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 668.66 477.1724 cm 0 0 m 0 -206.452 l S Q EMC endstream endobj 367 0 obj 14959 endobj %% Contents for page 27 %% Original object ID: 55 0 368 0 obj << /Length 369 0 R >> stream Q q BT /Xi25 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 369 0 obj 245 endobj %% Original object ID: 373 0 370 0 obj [ 2345 0 R 2346 0 R 2347 0 R 2348 0 R 2349 0 R 2350 0 R 2351 0 R ] endobj %% Contents for page 28 %% Original object ID: 56 0 371 0 obj << /Length 372 0 R >> stream q endstream endobj 372 0 obj 2 endobj %% Contents for page 28 %% Original object ID: 374 0 373 0 obj << /Length 374 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Follicular Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 728.6078 23.544 Tm [(FOLL)17.6 (-)35 (6)]TJ ET EMC /GS1 gs q 1 0 0 1 29.5212 74.3964 cm 0 0 m 171.733 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 0 Tc 0 Tw 8 0 0 8 23.7612 100.456 Tm (t)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm [(A)55.2 ( subgroup of low-risk patie)-1 (nts may only require an ultras)-1.1 (ound if there is a reasonable suspicion for recurrence. )]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 89.456 Tm (u)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT -0.001 Tw 10 0 0 10 29.5212 86.456 Tm [(In )0.6 (selected )0.5 (patients who may )0.6 (be at )0.6 (higher risk )0.5 (for )0.6 (residua)-0.8 (l/recurrent disease \(eg, )0.5 (N1 patients\), obtain a )0.5 (stimulated )18 (Tg )0.6 (and consider concomitant diagnostic RAI )0.5 (imaging.)]TJ ET EMC /Span <>BDC BT 0 Tw 8 0 0 8 23.7612 78.456 Tm (v)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 75.456 Tm [(See NCCN Guidelines for S)-0.8 (urvivorship)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 201.2546 75.456 Tm (.)Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 296.1994 427.5901 cm 0 0 m 0 -189.88 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.544 418.6458 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 418.6458 Tm (Physical examination, TSH and Tg measurement )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 406.6458 Tm (+)Tj /Span<>> BDC ( )Tj EMC (antithyroglobulin antibodies at 6 and 12 mo, )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 394.6458 Tm (then annually if disease-free)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 382.6458 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 382.6458 Tm (Periodic neck ultrasound)Tj ET EMC /Span <>BDC BT 9 0 0 9 161.8712 386.6458 Tm (t)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 370.6458 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 370.6458 Tm (Consider TSH-stimulated or TSH-unstimulated )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 358.6458 Tm (Tg measurements using an ultrasensitive )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 346.6458 Tm (assay in patients previously treated with RAI )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 334.6458 Tm (and with negative TSH-suppressed Tg and )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 322.6458 Tm (anti-thyroglobulin antibodies)Tj ET EMC /Span <>BDC BT 9 0 0 9 182.2894 326.6458 Tm (u)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 310.6458 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 310.6458 Tm (Consider TSH-stimulated radioiodine whole )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 298.6458 Tm (body imaging in high-risk patients, patients with )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 286.6458 Tm (previous RAI-avid metastases, or patients with )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 274.6458 Tm (abnormal Tg levels \(either TSH-suppressed or )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 262.6458 Tm (TSH-stimulated\), stable or rising antithyroglobulin )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 250.6458 Tm (antibodies, or abnormal ultrasound during )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 238.6458 Tm (surveillance)Tj ET EMC /Span <>BDC BT 0.035 Tc -0.035 Tw 11 0 0 11 386.3534 514.3517 Tm (MANAGEMENT)Tj ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 313.2369 401.8358 Tm (NED)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 342.72 405.84 cm 0 0 m 29.098 0 l S Q q 1 0 0 1 377.28 405.84 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 384 340.8999 cm 0 0 m 0 129.88 l S Q q 1 0 0 1 660 470.7802 cm 0 0 m 0 -129.88 l S Q 0.75 w q 1 0 0 1 386.16 460.6703 cm 0 0 m 158.292 0 l S Q /Span <>BDC BT 11 0 0 11 386.16 461.8359 Tm (Long-term disease monitoring)Tj ET EMC /Span <>BDC BT 9 0 0 9 544.4515 465.8359 Tm (v)Tj ET EMC /Span <>BDC BT 11 0 0 11 386.16 449.8359 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 393.0673 449.8359 Tm (Patients treated with iodine)Tj /Span<>> BDC (-)Tj EMC (131 ablation, with )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 393.36 437.8359 Tm [<0044000300510048004a00440057004c0059004800030058004f00570055004400560052005800510047000f000300560057004c00500058004f004400570048004700030037004a0003001f001500030051004a00120050002f>20.1 <0003>]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 393.36 425.8359 Tm (\(with negative antithyroglobulin antibodies\), )Tj ET EMC /Span <>BDC BT 11 0 0 11 393.36 413.8359 Tm (and negative RAI imaging \(if performed\) may be )Tj ET EMC /Span <>BDC BT 11 0 0 11 393.36 401.8359 Tm (followed by unstimulated thyroglobulin annually )Tj ET EMC /Span <>BDC BT 11 0 0 11 393.36 389.8359 Tm (and by periodic neck ultrasound. TSH-stimulated )Tj ET EMC /Span <>BDC BT 11 0 0 11 393.36 377.8359 Tm (testing, or other imaging \(eg, CT or MRI with )Tj ET EMC /Span <>BDC BT 11 0 0 11 393.36 365.8359 Tm (contrast\) as clinically appropriate, may be )Tj ET EMC /Span <>BDC BT 11 0 0 11 393.36 353.8359 Tm (considered if clinical suggestion of recurrent )Tj ET EMC /Span <>BDC BT 11 0 0 11 393.36 341.8359 Tm (disease.)Tj ET EMC /Span <>BDC BT 11 0 0 11 313.2369 258.2958 Tm (Abnormal)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 313.2369 246.2958 Tm <00bf00510047004c0051004a0056>Tj ET EMC 1 w q 1 0 0 1 384 221.3598 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 660 291.2401 cm 0 0 m 0 -69.88 l S Q 0.75 w q 1 0 0 1 386.16 281.1303 cm 0 0 m 95.938 0 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 386.16 282.2958 Tm (Additional workup)Tj ET EMC /Span <>BDC BT 11 0 0 11 386.16 270.2958 Tm (If iodine)Tj /Span<>> BDC (-)Tj EMC (131 imaging negative and stimulated Tg )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 386.16 258.2958 Tm <0021001500b1001800030051004a00120050002f000f00030046005200510056004c0047004800550003004400470047004c0057004c005200510044004f0003005100520051005500440047004c0052004c00520047004c005100480003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 386.16 246.2958 Tm (imaging \(eg, central and lateral neck compartments )Tj ET EMC /Span <>BDC BT 11 0 0 11 386.16 234.2958 Tm (ultrasound, neck CT with contrast, chest CT with )Tj ET EMC /Span <>BDC BT 11 0 0 11 386.16 222.2958 Tm (contrast, PET/CT\))Tj ET EMC /Artifact <>BDC 1 w 4 M /GS1 gs q 1 0 0 1 362.68 256.3001 cm 0 0 m 11.858 0 l S Q q 1 0 0 1 380 256.3001 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 696.148 388.8998 cm 0 0 m 0 33.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 698.308 388.6703 cm 0 0 m 68.449 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 698.308 413.8358 Tm (Recurrent)Tj ET EMC /Span <>BDC BT 11 0 0 11 698.308 401.8358 Tm (disease)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 698.308 389.8358 Tm (\(See FOLL-7\))Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 662.8174 405.84 cm 0 0 m 26.315 0 l S Q 0 0 0 scn q 1 0 0 1 694.5944 405.84 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 662.8174 256.3001 cm 0 0 m 26.315 0 l S Q q 1 0 0 1 694.5943 256.3001 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 696.148 215.3599 cm 0 0 m 0 81.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 698.308 263.1303 cm 0 0 m 68.449 0 l S Q q 1 0 0 1 698.308 215.1303 cm 0 0 m 68.449 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 698.308 288.2959 Tm (Recurrent)Tj ET EMC /Span <>BDC BT 11 0 0 11 698.308 276.2959 Tm (disease)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 698.308 264.2959 Tm (\(See FOLL-7\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 698.308 252.2959 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 698.308 240.2959 Tm (Metastatic)Tj ET EMC /Span <>BDC BT 11 0 0 11 698.308 228.2959 Tm (disease)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 698.308 216.2959 Tm (\(See FOLL-8\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 0.034 Tc -0.034 Tw 11 0 0 11 313.4303 514.3517 Tm (FINDINGS)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 312.1389 271.6822 cm 0 0 m -15.292 60.968 l -0.155 121.932 l S Q q 1 0 0 1 313.4678 266.3842 cm 0 0 m 0.769 7.422 l -4.181 6.181 l h f Q q 1 0 0 1 313.3002 398.9158 cm 0 0 m -4.166 -6.191 l 0.787 -7.421 l h f Q EMC /Span <>BDC BT 0.035 Tc -0.054 Tw 11 0 0 11 23.738 514.3517 Tm [(DISEASE)17.5 ( )-36.4 (MONIT)18.1 (ORING)17.6 ( )0.7 (AND)17.3 ( )]TJ ET EMC /Span <>BDC BT -0.035 Tw 11 0 0 11 23.738 502.3517 Tm (MAINTENANCE)Tj ET EMC endstream endobj 374 0 obj 12241 endobj %% Contents for page 28 %% Original object ID: 57 0 375 0 obj << /Length 376 0 R >> stream Q q BT /Xi26 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 376 0 obj 245 endobj %% Original object ID: 376 0 377 0 obj [ 2352 0 R 2353 0 R 2354 0 R 2355 0 R 2356 0 R 2357 0 R 2358 0 R 2359 0 R 2360 0 R ] endobj %% Contents for page 29 %% Original object ID: 58 0 378 0 obj << /Length 379 0 R >> stream q endstream endobj 379 0 obj 2 endobj %% Contents for page 29 %% Original object ID: 377 0 380 0 obj << /Length 381 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Follicular Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 728.6078 23.544 Tm [(FOLL)17.6 (-)35 (7)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 188.7768 502.9997 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 494.0554 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 494.0554 Tm [(Stimulated Tg 1\22610 ng/mL)19 ( )]TJ ET EMC /Span <>BDC BT 11 0 0 11 30.744 482.0554 Tm (and negative imaging)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 470.0554 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 470.0554 Tm (Non-resectable tumors)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 458.0554 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 458.0554 Tm (Non-radioiodine responsive)Tj ET EMC /Span <>BDC BT 9 0 0 9 175.9166 462.0554 Tm (w)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 188.64 480.0596 cm 0 0 m 6.058 0 l S Q q 1 0 0 1 200.16 480.0596 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 207.2284 476.0554 Tm (Suppress TSH with levothyroxine)Tj ET EMC /Span <>BDC BT 9 0 0 9 382.0414 480.0554 Tm (f)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 306.8642 Tm (Locoregional )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 294.8642 Tm (recurrence)Tj ET EMC 10 M q 1 0 0 1 205.0684 227.9281 cm 0 0 m 0 153.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 522.0134 263.6986 cm 0 0 m 38.495 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 207.2284 372.8641 Tm (Surgery \(preferred\) if resectable)Tj ET EMC /Span <>BDC BT 9 0 0 9 374.7367 376.8641 Tm (y)Tj ET EMC /Span <>BDC BT 11 0 0 11 207.2284 360.8641 Tm (and/or )Tj ET EMC /Span <>BDC BT 11 0 0 11 207.2284 348.8641 Tm (Radioiodine treatment,)Tj ET EMC /Span <>BDC BT 9 0 0 9 326.4076 352.8641 Tm (z )Tj ET EMC /Span <>BDC BT 11 0 0 11 333.4081 348.8641 Tm (if radioiodine imaging positive )Tj ET EMC /Span <>BDC BT 11 0 0 11 207.2284 336.8641 Tm (or)Tj ET EMC /Span <>BDC BT -0.004 Tw 11 0 0 11 207.2284 324.8641 Tm [(Disease monitoring )1.2 (for )0.5 (non-progressive disease that )0.5 (is stable and )0.6 (distant )0.6 (from critical structures)]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 207.2284 312.8641 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 207.2284 300.8641 Tm (For select patients with unresectable, non\226radioiodine-avid, and progressive disease, consider: ) Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 210.8284 288.8641 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 221.8284 288.8641 Tm (EBRT \(IMRT/SBRT\))Tj ET EMC /Span <>BDC BT 9 0 0 9 322.0369 292.8641 Tm (h)Tj ET EMC /Span <>BDC BT 11 0 0 11 327.5345 288.8641 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 221.6284 276.8641 Tm (and/or)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 210.8284 264.8641 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 221.8284 264.8641 Tm (Systemic therapies \()Tj ET EMC /Span <>BDC BT 11 0 0 11 328.8206 264.8641 Tm [(See T)55.2 (reatment of Metastatic Disease )]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 522.0134 264.8641 Tm (FOLL-8)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 560.5081 264.8641 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 207.2284 252.8641 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 207.2284 240.8641 Tm (For select patients with limited burden nodal disease, consider local therapies when available ) Tj ET EMC /Span <>BDC BT 11 0 0 11 699.9242 240.8641 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 207.2284 228.8641 Tm [(\(eg, ethanol ablation, RF)56.8 (A\))]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.544 180.8559 Tm (Metastatic disease)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 132.48 184.86 cm 0 0 m 62.218 0 l S Q q 1 0 0 1 200.16 184.86 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 205.0684 155.9198 cm 0 0 m 0 57.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 207.2284 155.6903 cm 0 0 m 61.123 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 207.2284 204.8559 Tm (RAI therapy for iodine)Tj /Span<>> BDC (-)Tj EMC (avid disease)Tj ET EMC /Span <>BDC BT 9 0 0 9 391.2206 208.8559 Tm (h)Tj ET EMC /Span <>BDC BT 11 0 0 11 207.2284 192.8559 Tm (and/or)Tj ET EMC /Span <>BDC BT 11 0 0 11 207.2284 180.8559 Tm (Local therapies when available)Tj ET EMC /Span <>BDC BT 9 0 0 9 368.6244 184.8559 Tm (aa)Tj ET EMC /Span <>BDC BT 11 0 0 11 207.2284 168.8559 Tm (and/or)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 207.2284 156.8559 Tm (See FOLL-8)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 268.3514 156.8559 Tm ( if not amenable to RAI)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 188.28 304.8683 cm 0 0 m 6.418 0 l S Q q 1 0 0 1 200.16 304.8683 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 0.035 Tc -0.017 Tw 11 0 0 11 23.7374 514.3517 Tm [(RECURRENT)17.6 ( )0.6 (DISEASE)]TJ ET EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 29.304 85.3276 cm 0 0 m 205.444 0 l S Q q 1 0 0 1 29.304 74.3276 cm 0 0 m 245.474 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 0 Tc 0 Tw 8 0 0 8 23.544 89.3872 Tm (f)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.304 86.3872 Tm [(See Principle)-0.8 (s of )18.2 (TSH Suppression \(THYR-A\).)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 8 0 0 8 23.544 78.3872 Tm (h)Tj ET EMC /Span <>BDC BT /Span<>> BDC 8 0 0 8 27.9932 78.3872 Tm ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.304 75.3872 Tm (See )Tj ET EMC /Span <>BDC BT 10 0 0 10 49.8753 75.3872 Tm [(Principle)-0.8 (s of Radiation )-0.7 (and RAI )18.1 (Therapy \(THYR)]TJ /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 274.7776 75.3872 Tm (.)Tj ET EMC /GS1 gs q 1 0 0 1 406.614 85.3277 cm 0 0 m 245.474 0 l S Q /Span <>BDC BT /GS0 gs 8 0 0 8 400.3914 199.3872 Tm (w )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 408.3914 196.3872 Tm [(Generally)73.4 (, a tumor is considered iodine-responsive if follow-up iodine)]TJ /Span<>> BDC (-)Tj EMC (123 or )Tj ET EMC /Span <>BDC BT 10 0 0 10 408.3914 185.3872 Tm (low-dose iodine)Tj /Span<>> BDC (-)Tj EMC (131 \(1\2263 mCi\) whole body diagnostic imaging done 6\22612 mo )Tj ET EMC /Span <>BDC BT 10 0 0 10 408.3914 174.3872 Tm (after iodine)Tj /Span<>> BDC (-)Tj EMC (131 treatment is negative or shows decreasing uptake compared )Tj ET EMC /Span <>BDC BT 10 0 0 10 408.3914 163.3872 Tm (to pre-treatment scans. It is recommended to use the same preparation and ) Tj ET EMC /Span <>BDC BT 10 0 0 10 408.3914 152.3872 Tm [(imaging method employed for the pre-treatment scan and therapy)71.4 (. Favorable )]TJ ET EMC /Span <>BDC BT 10 0 0 10 408.3914 141.3872 Tm (response to iodine)Tj /Span<>> BDC (-)Tj EMC (131 treatment is additionally assessed through change in )Tj ET EMC /Span <>BDC BT 10 0 0 10 408.3914 130.3872 Tm (volume of known iodine-concentrated lesions by CT/MRI, and by decreasing ) Tj ET EMC /Span <>BDC BT 10 0 0 10 408.3914 119.3872 Tm (unstimulated or stimulated thyroglobulin levels. )Tj ET EMC /Span <>BDC BT 8 0 0 8 400.3914 111.3872 Tm (y)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 406.1514 108.3872 Tm [(Preoperative vocal cord ass)-0.7 (essment, if central neck recurrence.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 400.3914 100.3872 Tm (z )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 406.614 97.3872 Tm (The administered activity of RAI therapy should be adjusted for pediatric patients. ) Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 406.614 86.3872 Tm (See )Tj ET EMC /Span <>BDC BT 10 0 0 10 427.1853 86.3872 Tm [(Principles of Radiation and RAI )16.4 (Therapy \(THYR)]TJ /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 652.0876 86.3872 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 400.3914 78.3872 Tm (aa )Tj ET EMC /Span <>BDC BT 10 0 0 10 411.5125 75.3872 Tm [(Ethanol ablation, cryoablation, RF)53.4 (A, etc.)]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 391.3914 480.0596 cm 0 0 m 22.4 0 l S Q q 1 0 0 1 419.2533 480.0596 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 422.64 469.1194 cm 0 0 m 0 21.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 702.2975 468.8899 cm 0 0 m 68.449 0 l S Q /Span <>BDC BT /GS0 gs /TT1 1 Tf 11 0 0 11 424.8 482.0554 Tm (Continue surveillance with unstimulated Tg,)Tj ET EMC /Span <>BDC BT 11 0 0 11 424.8 470.0554 Tm (ultrasound, and other imaging as clinically indicated )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 702.2975 470.0554 Tm (\(See FOLL-6\))Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 168.48 446.0201 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 0 0 0 scn 11 0 0 11 23.544 437.0758 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 437.0758 Tm (Progressively rising Tg )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 425.0758 Tm (\(basal or stimulated\))Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 413.0758 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 413.0758 Tm (Scans \(including PET\) )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 401.0758 Tm (negative )Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 169.2 423.08 cm 0 0 m 25.498 0 l S Q q 1 0 0 1 200.16 423.08 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 205.0684 394.1398 cm 0 0 m 0 57.88 l S Q /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 207.2284 443.0758 Tm <0026005200510056004c0047004800550003005500440047004c0052004c00520047004c0051004800030057004b0048005500440053005c0003005a004c0057004b00030095001400130013000300500026004c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 207.2284 431.0758 Tm (and )Tj ET EMC /Span <>BDC BT 11 0 0 11 207.2284 419.0758 Tm (Post-treatment iodine)Tj /Span<>> BDC (-)Tj EMC (131 imaging \(category 3\); additional RAI )Tj ET EMC /Span <>BDC BT -0.002 Tw 11 0 0 11 207.2284 407.0758 Tm [(treatments should )1.4 (be )0.6 (limited )0.7 (to )0.8 (patients )0.6 (who )1.1 (responded )0.8 (to )0.8 (previous )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 207.2284 395.0758 Tm (RAI therapy \(minimum of 6\22612 months between RAI treatments\))Tj ET EMC q 1 0 0 1 117.7546 281.9281 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 188.1534 327.8084 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 11 0 0 11 119.9146 318.8641 Tm (Consider )Tj ET EMC /Span <>BDC BT 11 0 0 11 119.9146 306.8641 Tm (preoperative )Tj ET EMC /Span <>BDC BT 11 0 0 11 119.9146 294.8641 Tm (iodine total )Tj ET EMC /Span <>BDC BT 11 0 0 11 119.9146 282.8641 Tm (body scan)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 97.744 304.8683 cm 0 0 m 13.731 0 l S Q q 1 0 0 1 116.9373 304.8683 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC endstream endobj 381 0 obj 15265 endobj %% Contents for page 29 %% Original object ID: 59 0 382 0 obj << /Length 383 0 R >> stream Q q BT /Xi27 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 383 0 obj 245 endobj %% Original object ID: 379 0 384 0 obj [ 2361 0 R 2362 0 R 2363 0 R 2364 0 R 2365 0 R 2366 0 R 2367 0 R 2368 0 R 2369 0 R 2370 0 R 2371 0 R 2372 0 R 2373 0 R 2374 0 R ] endobj %% Contents for page 30 %% Original object ID: 60 0 385 0 obj << /Length 386 0 R >> stream q endstream endobj 386 0 obj 2 endobj %% Contents for page 30 %% Original object ID: 380 0 387 0 obj << /Length 388 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Follicular Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 294.46 437.5785 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 294.46 329.5785 cm 0 0 m 0 69.88 l S Q /Span <>BDC BT 0 0 0 scn /TT1 1 Tf 11 0 0 11 296.62 474.5145 Tm (Unresectable )Tj ET EMC /Span <>BDC BT 11 0 0 11 296.62 462.5145 Tm (locoregional )Tj ET EMC /Span <>BDC BT 11 0 0 11 296.62 450.5145 Tm (recurrent/)Tj ET EMC /Span <>BDC BT 11 0 0 11 296.62 438.5145 Tm (persistent disease)Tj ET EMC /Span <>BDC BT 11 0 0 11 296.62 414.5145 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 296.62 390.5145 Tm (Soft tissue )Tj ET EMC /Span <>BDC BT 11 0 0 11 296.62 378.5145 Tm (metastases )Tj ET EMC /Span <>BDC BT 11 0 0 11 296.62 366.5145 Tm [(\(eg, lung, liver)56.4 (, )]TJ ET EMC /Span <>BDC BT 11 0 0 11 296.62 354.5145 Tm (muscle\) excluding )Tj ET EMC /Span <>BDC BT 11 0 0 11 296.62 342.5145 Tm (CNS metastases )Tj ET EMC /Span <>BDC BT 11 0 0 11 296.62 330.5145 Tm (\(see below\))Tj ET EMC /Span <>BDC BT 11 0 0 11 296.62 186.1847 Tm (CNS metastases)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 398 482.5578 cm 0 0 m 0 -152.078 l S Q EMC /Artifact <>BDC q 1 0 0 1 398.76 406.5187 cm 0 0 m 7.578 0 l S Q q 1 0 0 1 411.8 406.5187 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 389.5884 253.6758 cm 0 0 m 16.749 0 l S Q q 1 0 0 1 411.8 253.6758 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 388.6 190.1888 cm 0 0 m 17.738 0 l S Q q 1 0 0 1 411.8 190.1888 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT /GS0 gs 0.035 Tc -0.017 Tw 11 0 0 11 23.7377 514.3517 Tm [(TREA)73.9 (TMENT)17.6 ( )0.6 (OF)17.6 ( )0.6 (LOCALL)91.8 (Y)35.5 ( )0.6 (RECURRENT)128.4 (,)35.2 ( )37.7 (ADV)74.1 (ANCED)17.3 (,)35.1 ( )37.7 (AND)17.3 (/)17.5 (OR)17.2 ( )0.6 (MET)74.2 (AST)74.2 (A)73.9 (TIC)17.3 ( )0.6 (DISEASE)17.5 ( )0.5 (NOT)17.6 ( )37.7 (AMENABLE)17.5 ( )0.6 (T)18 (O)17.6 ( )0.6 (RAI)17.6 ( )0.6 (THERAPY)]TJ ET EMC 10 M q 1 0 0 1 414.4284 276.5785 cm 0 0 m 0 225.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 654.2405 336.349 cm 0 0 m 89.23 0 l S Q q 1 0 0 1 423.7884 324.349 cm 0 0 m 106.38 0 l S Q q 1 0 0 1 712.3538 300.349 cm 0 0 m 26.292 0 l S Q q 1 0 0 1 423.7884 288.349 cm 0 0 m 42.158 0 l S Q q 1 0 0 1 539.0332 276.349 cm 0 0 m 209.682 0 l S Q /Span <>BDC BT /GS0 gs 0 Tc 0 Tw 11 0 0 11 416.5884 493.5145 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 423.4956 493.5145 Tm (Consider systemic therapy)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 420.1884 481.5145 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 431.1884 481.5145 Tm (For progressive and/or symptomatic disease, consider )Tj ET EMC /Span <>BDC BT 11 0 0 11 430.9884 469.5145 Tm (lenvatinib \(preferred\))Tj ET EMC /Span <>BDC BT 9 0 0 9 541.0099 473.5145 Tm (bb)Tj ET EMC /Span <>BDC BT 11 0 0 11 552.005 469.5145 Tm ( or sorafenib.)Tj ET EMC /Span <>BDC BT 9 0 0 9 621.6842 473.5145 Tm (cc,dd)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 420.1884 457.5145 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 431.1884 457.5145 Tm (Larotrectinib or entrectinib for patients with )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 662.8168 457.5145 Tm (NTRK)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 693.3676 457.5145 Tm ( gene fusion)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 430.9884 445.5145 Tm (positive advanced solid tumors.)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 420.1884 433.5145 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 431.1884 433.5145 Tm (Selpercatinib )Tj ET EMC /Span <>BDC BT 11 0 0 11 503.3222 433.5145 Tm (for patients with )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 591.3222 433.5145 Tm (RET)Tj ET EMC /Span <>BDC BT /TT1 1 Tf /Span<>> BDC 11 0 0 11 613.3222 433.5145 Tm (-)Tj EMC (fusion positive tumors)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 420.1884 421.5145 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 431.1884 421.5145 Tm <003300480050004500550052004f004c005d005800500044004500030049005200550003005300440057004c00480051005700560003005a004c0057004b00030037003000250010002b0003000b0095001400130003005000580057001200300045000c0003005700580050005200550056>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 420.1884 409.5145 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 431.1884 409.5145 Tm (Other therapies are available and can be considered for )Tj ET EMC /Span <>BDC BT 11 0 0 11 430.9884 397.5145 Tm (progressive and/or symptomatic disease if clinical trials or other )Tj ET EMC /Span <>BDC BT 11 0 0 11 430.9884 385.5145 Tm (systemic therapies are not available or )Tj ET EMC /Span <>BDC BT 11 0 0 11 636.4166 385.5145 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 430.9884 373.5145 Tm (appropriate.)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 9 0 0 9 494.5553 377.5145 Tm <00480048000f1087>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 416.5884 361.5145 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 423.4956 361.5145 Tm (Consider resection of distant metastases and/or EBRT \(SBRT/)Tj ET EMC /Span <>BDC BT 11 0 0 11 423.7884 349.5145 Tm (IMRT\))Tj ET EMC /Span <>BDC BT 9 0 0 9 454.3338 353.5145 Tm (h)Tj ET EMC /Span <>BDC BT 11 0 0 11 459.8314 349.5145 Tm (/other local therapies)Tj ET EMC /Span <>BDC BT 9 0 0 9 570.4759 353.5145 Tm (aa)Tj ET EMC /Span <>BDC BT 11 0 0 11 580.4866 349.5145 Tm ( when available to metastatic )Tj ET EMC /Span <>BDC BT 11 0 0 11 423.7884 337.5145 Tm (lesions if progressive and/or symptomatic. \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 654.2405 337.5145 Tm (For locoregional )Tj ET EMC /Span <>BDC BT 11 0 0 11 423.7884 325.5145 Tm (disease, see FOLL-7)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 530.1683 325.5145 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 416.5884 313.5145 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 423.4956 313.5145 Tm (Disease monitoring is often appropriate in asymptomatic patients )Tj ET EMC /Span <>BDC BT 11 0 0 11 423.7884 301.5145 Tm (with indolent disease assuming no brain metastasis.)Tj ET EMC /Span <>BDC BT 9 0 0 9 698.8582 305.5145 Tm (dd )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 712.3538 301.5145 Tm (\(See )Tj ET EMC /Span <>BDC BT 11 0 0 11 423.7884 289.5145 Tm (FOLL-6\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 416.5884 277.5145 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 423.4956 277.5145 Tm (Best supportive care \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 539.0332 277.5145 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 561.6616 277.5145 Tm (NCCN Guidelines for Palliative Care)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 748.7153 277.5145 Tm (\))Tj ET EMC /GS1 gs q 1 0 0 1 29.304 162.3276 cm 0 0 m 205.444 0 l S Q q 1 0 0 1 29.304 151.3276 cm 0 0 m 245.474 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 8 0 0 8 23.544 166.3872 Tm (f)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.304 163.3872 Tm [(See Principle)-0.8 (s of )18.2 (TSH Suppression \(THYR-A\).)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 8 0 0 8 23.544 155.3872 Tm (h)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.304 152.3872 Tm [(See Principle)-0.8 (s of Radiation )-0.8 (and RAI )18.1 (Therapy \(THYR)]TJ /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 274.7776 152.3872 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 144.3872 Tm (aa )Tj ET EMC /Span <>BDC BT 10 0 0 10 34.6651 141.3872 Tm [(Ethanol ablation, cryoablation, RF)53.4 (A, etc.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.544 133.3872 Tm (bb )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 34.6651 130.3872 Tm (In a subset of patients \(older than 65 years of age\), lenvatinib showed an ) Tj ET EMC /Span <>BDC BT 10 0 0 10 34.6651 119.3872 Tm (overall survival benefit compared to placebo. Brose MS, et al. J Clin Oncol ) Tj ET EMC /Span <>BDC BT 10 0 0 10 34.6651 108.3872 Tm (2017;35:2692-2699.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 100.3872 Tm (cc )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 33.7667 97.3872 Tm (The decision of whether to use lenvatinib \(preferred\) or sorafenib should ) Tj ET EMC /Span <>BDC BT 10 0 0 10 33.7667 86.3872 Tm (be individualized for each patient based on likelihood of response and )Tj ET EMC /Span <>BDC BT 10 0 0 10 33.7667 75.3872 Tm (comorbidities.)Tj ET EMC /GS1 gs q 1 0 0 1 573.7008 151.3276 cm 0 0 m 188.809 0 l S Q q 1 0 0 1 411.3961 140.3276 cm 0 0 m 43.882 0 l S Q /Span <>BDC BT /GS0 gs 8 0 0 8 400.275 166.3872 Tm (dd )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 411.3961 163.3872 Tm (Kinase inhibitor therapy may not be appropriate for patients with stable or ) Tj ET EMC /Span <>BDC BT 10 0 0 10 411.3961 152.3872 Tm (slowly progressive indolent disease. )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 573.7008 152.3872 Tm [(See Principles of Kinase Inhibitor )16.4 (Therapy )]TJ ET EMC /Span <>BDC BT 10 0 0 10 411.3961 141.3872 Tm (\(THYR-B\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 455.278 141.3872 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 400.275 133.3872 Tm (ee )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 411.3961 130.3872 Tm (Commercially available small-molecule kinase inhibitors \(such as axitinib, ) Tj ET EMC /Span <>BDC BT 10 0 0 10 411.3961 119.3872 Tm (everolimus, pazopanib, sunitinib, vandetanib, vemurafenib [)Tj ET EMC /Span <>BDC BT /TT3 1 Tf 10 0 0 10 674.3307 119.3872 Tm [(BRAF)18.1 ( )]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 10 0 0 10 703.5983 119.3872 Tm (positive], )Tj ET EMC /Span <>BDC BT 10 0 0 10 411.3961 108.3872 Tm (dabrafenib [)Tj ET EMC /Span <>BDC BT /TT3 1 Tf 10 0 0 10 464.2135 108.3872 Tm [(BRAF)18.1 ( )]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 10 0 0 10 493.4811 108.3872 Tm (positive], or cabozantinib [all are category 2A]\) can be )Tj ET EMC /Span <>BDC BT 10 0 0 10 411.3961 97.3872 Tm (considered if clinical trials are not available or appropriate. )Tj ET EMC /Span <>BDC BT -0.018 Tc 0.018 Tw 8 0 0 8 400.275 89.3872 Tm [(ff)-17.8 ( )]TJ /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 Tc 0 Tw 10 0 0 10 406.7985 86.3872 Tm [(Cytotoxic chemotherapy has been shown to have minimal ef)15.4 (ficacy)74.1 (, although most )]TJ ET EMC /Span <>BDC BT 10 0 0 10 406.7985 75.3872 Tm (studies were small and underpowered. )Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS1 gs q 1 0 0 1 290.819 196.8669 cm 0 0 m -24.708 118.32 l -0.25 236.638 l S Q q 1 0 0 1 291.9355 191.52 cm 0 0 m 1.064 7.386 l -3.931 6.343 l h f Q q 1 0 0 1 291.6751 438.8544 cm 0 0 m -3.918 -6.351 l 1.079 -7.384 l h f Q EMC /Artifact <>BDC q 1 0 0 1 287.7565 268.5007 cm 0 0 m -21.606 46.687 l -0.222 93.364 l S Q q 1 0 0 1 290.0506 263.5436 cm 0 0 m -0.629 7.436 l -5.261 5.292 l h f Q q 1 0 0 1 289.8096 366.8307 cm 0 0 m -5.24 -5.312 l -0.601 -7.438 l h f Q EMC /Span <>BDC BT /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 728.6078 23.544 Tm [(FOLL)17.6 (-)35 (8)]TJ ET EMC 10 M q 1 0 0 1 129.5254 375.1531 cm 0 0 m 0 -81.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 366.2088 Tm (Structurally )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 354.2088 Tm [(p)0.7 (ersi)0.7 (st)0.5 (en)0.7 (t)0.5 (/)0.6 (recu)0.6 (rren)0.7 (t )]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.544 342.2088 Tm (locoregional or )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 330.2088 Tm (distant metastatic )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 318.2088 Tm (disease not )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 306.2088 Tm (amenable to RAI )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 294.2088 Tm (therapy)Tj ET EMC /Span <>BDC BT 11 0 0 11 296.62 249.6716 Tm (Bone metastases)Tj ET EMC 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 416.5884 248.5061 cm 0 0 m 61.123 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 416.5884 249.6716 Tm (See FOLL-9)Tj ET EMC q 1 0 0 1 416.5884 185.0192 cm 0 0 m 61.123 0 l S Q /Span <>BDC BT 11 0 0 11 416.5884 186.1847 Tm (See FOLL-9)Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 147.6697 227.2728 cm 0 0 m 0 189.88 l S Q q 1 0 0 1 265.1948 417.1531 cm 0 0 m 0 -189.88 l S Q /Span <>BDC BT 0 0 0 scn 11 0 0 11 149.8297 408.2088 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 156.7369 408.2088 Tm (Continue to )Tj ET EMC /Span <>BDC BT 11 0 0 11 157.0297 396.2088 Tm (suppress TSH with )Tj ET EMC /Span <>BDC BT 11 0 0 11 157.0297 384.2088 Tm (levothyroxine)Tj ET EMC /Span <>BDC BT 9 0 0 9 228.5512 388.2088 Tm (f)Tj ET EMC /Span <>BDC BT 11 0 0 11 149.8297 372.2088 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 156.7369 372.2088 Tm (For advanced, )Tj ET EMC /Span <>BDC BT 11 0 0 11 157.0297 360.2088 Tm (progressive, or )Tj ET EMC /Span <>BDC BT -0.033 Tw 11 0 0 11 157.0297 348.2088 Tm (threatening disease, )Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 157.0297 336.2088 Tm (genomic testing to )Tj ET EMC /Span <>BDC BT 11 0 0 11 157.0297 324.2088 Tm (identify actionable )Tj ET EMC /Span <>BDC BT 11 0 0 11 157.0297 312.2088 Tm (mutations )Tj ET EMC /Span <>BDC BT 11 0 0 11 157.0297 300.2088 Tm (\(including )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 212.6313 300.2088 Tm (NTRK)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 243.182 300.2088 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 157.0297 288.2088 Tm (and )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 179.642 288.2088 Tm (RET)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 201.642 288.2088 Tm ( gene )Tj ET EMC /Span <>BDC BT 11 0 0 11 157.0297 276.2088 Tm (fusions\) and tumor )Tj ET EMC /Span <>BDC BT 11 0 0 11 157.0297 264.2088 Tm (mutational burden )Tj ET EMC /Span <>BDC BT 11 0 0 11 157.0297 252.2088 Tm (\(TMB\))Tj ET EMC /Span <>BDC BT 11 0 0 11 149.8297 240.2088 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 156.7369 240.2088 Tm (Consider clinical )Tj ET EMC /Span <>BDC BT 11 0 0 11 157.0297 228.2088 Tm (trial)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 131.04 334.213 cm 0 0 m 10.378 0 l S Q q 1 0 0 1 146.88 334.213 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC endstream endobj 388 0 obj 19788 endobj %% Contents for page 30 %% Original object ID: 61 0 389 0 obj << /Length 390 0 R >> stream Q q BT /Xi28 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 390 0 obj 245 endobj %% Original object ID: 382 0 391 0 obj [ 2375 0 R 2376 0 R 2377 0 R 2378 0 R 2379 0 R 2380 0 R 2381 0 R ] endobj %% Contents for page 31 %% Original object ID: 62 0 392 0 obj << /Length 393 0 R >> stream q endstream endobj 393 0 obj 2 endobj %% Contents for page 31 %% Original object ID: 383 0 394 0 obj << /Length 395 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Follicular Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 728.6078 23.544 Tm [(FOLL)17.6 (-)35 (9)]TJ ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 23.7374 519.3517 Tm [(TREA)73.9 (TMENT)17.6 ( )0.6 (OF)17.6 ( )0.6 (MET)74.2 (AST)74.2 (A)73.9 (TIC)17.3 ( )0.5 (DISEASE)17.4 ( )0.6 (NOT)17.6 ( )37.7 (AMENABLE)17.5 ( )0.6 (T)18 (O)17.6 ( )0.6 (RAI)17.6 ( )0.6 (THERAPY)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 9 0 0 9 438.4503 523.3517 Tm (gg)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.7612 254.9517 Tm (CNS metastases)Tj ET EMC 0.637 w /GS1 gs q 1 0 0 1 99.1541 114.3278 cm 0 0 m 197.787 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 6.8 0 0 6.8 23.544 157.7784 Tm (aa )Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 32.9969 155.2284 Tm [(Ethanol ablation, cryoablation, RF)53.4 (A, etc.)]TJ ET EMC /Span <>BDC BT 6.8 0 0 6.8 23.544 147.7784 Tm (cc )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 32.2332 145.2284 Tm (The decision of whether to use lenvatinib \(preferred\) or sorafenib should be individualized for ) Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 32.2332 135.2284 Tm (each patient based on likelihood of response and comorbidities.)Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 23.544 127.7784 Tm (dd )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 32.9969 125.2284 Tm (Kinase inhibitor therapy may not be appropriate for patients with stable or slowly progressive ) Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 32.9969 115.2284 Tm (indolent disease. )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 8.5 0 0 8.5 99.1541 115.2284 Tm [(See Principles of Kinase Inhibitor )16.4 (Therapy \(THYR-B\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 8.5 0 0 8.5 296.941 115.2284 Tm (.)Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 23.544 107.7784 Tm (ee )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 32.9969 105.2284 Tm (Commercially available small-molecule kinase inhibitors \(such as axitinib, everolimus, ) Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 32.9969 95.2284 Tm (pazopanib, sunitinib, vandetanib, vemurafenib [)Tj ET EMC /Span <>BDC BT /TT2 1 Tf 8.5 0 0 8.5 210.671 95.2284 Tm [(BRAF)18.1 ( )]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 8.5 0 0 8.5 235.5484 95.2284 Tm (positive], dabrafenib [)Tj ET EMC /Span <>BDC BT /TT2 1 Tf 8.5 0 0 8.5 316.3482 95.2284 Tm [(BRAF)18.1 ( )]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 8.5 0 0 8.5 341.2257 95.2284 Tm (positive], )Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 32.9969 85.2284 Tm (or cabozantinib [all are category 2A]\) can be considered if clinical trials are not available or ) Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 32.9969 75.2284 Tm (appropriate. )Tj ET EMC /Span <>BDC BT -0.018 Tc 0.018 Tw 6.8 0 0 6.8 399.4425 167.7784 Tm [(ff)-17.8 ( )]TJ /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 Tc 0 Tw 8.5 0 0 8.5 404.9874 165.2284 Tm [(Cytotoxic chemotherapy has been shown to have minimal ef)15.4 (ficacy)74.1 (, although most studies were )]TJ ET EMC /Span <>BDC BT 8.5 0 0 8.5 404.9874 155.2284 Tm (small and underpowered. )Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 399.4425 147.7784 Tm (gg )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 408.8954 145.2284 Tm (RAI therapy is an option in some patients with bone metastases and RAI)Tj /Span<>> BDC (-)Tj EMC (sensitive disease.)Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 399.4425 137.7784 Tm (hh )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 408.8954 135.2284 Tm (Denosumab and intravenous bisphosphonates can be associated with severe hypocalcemia; ) Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 408.8954 125.2284 Tm (patients with hypoparathyroidism and vitamin D deficiency are at increased risk of ) Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 408.8954 115.2284 Tm (hypocalcemia. )Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 399.4425 107.7784 Tm (ii )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 404.3532 105.2284 Tm [(After consultation with neurosurgery and radiation oncology; data on the ef) 14.7 (ficacy of lenvatinib or )]TJ ET EMC /Span <>BDC BT 8.5 0 0 8.5 404.3532 95.2284 Tm (sorafenib for patients with brain metastases have not been established.)Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 399.4425 87.7784 Tm (jj )Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 404.3532 85.2284 Tm (TKI therapy should be used with caution in otherwise untreated CNS metastases due to bleeding ) Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 404.3385 75.2284 Tm (risk.)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS1 gs q 1 0 0 1 113.04 258.9559 cm 0 0 m 55.599 0 l S Q q 1 0 0 1 174.1012 258.9559 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 176.0612 177.0157 cm 0 0 m 0 163.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 300.666 176.7862 cm 0 0 m 209.682 0 l S Q /Span <>BDC BT /GS0 gs /TT1 1 Tf 11 0 0 11 178.2212 331.9517 Tm <9520>Tj ET EMC /Span <>BDC BT -0.001 Tw 11 0 0 11 185.1284 331.9517 Tm [(For solitary CNS lesions, either neurosurgical resection or stereotactic ) -0.7 (radiosurgery is preferred)]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 688.7421 331.9517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 185.4212 320.9517 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 178.2212 309.9517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 185.1284 309.9517 Tm [(For multiple CNS lesions, consider radiotherapy)75.7 (, including image-guided radiotherapy)76.4 (, and/or )]TJ ET EMC /Span <>BDC BT 11 0 0 11 185.4212 298.9517 Tm (resection in select cases)Tj ET EMC /Span <>BDC BT 11 0 0 11 315.0526 298.9517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 185.4212 287.9517 Tm (and/or)Tj ET EMC /Span <>BDC BT 11 0 0 11 178.2212 276.9517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 185.1284 276.9517 Tm (Consider systemic therapy)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 181.8212 265.9517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 192.8212 265.9517 Tm (For progressive and/or symptomatic disease, consider lenvatinib \(preferred\) or sorafenib) Tj ET EMC /Span <>BDC BT 9 0 0 9 658.6186 269.9517 Tm (cc,ii)Tj ET EMC /Span <>BDC BT 11 0 0 11 676.1308 265.9517 Tm (,jj)Tj ET EMC /Span <>BDC BT 9 0 0 9 685.2993 269.9517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 192.6212 254.9517 Tm (and/or)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 181.8212 243.9517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 192.8212 243.9517 Tm (Larotrectinib or entrectinib for patients with )Tj ET EMC /Span <>BDC BT /TT3 1 Tf 11 0 0 11 424.4496 243.9517 Tm (NTRK)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 455.0004 243.9517 Tm ( gene fusion)Tj /Span<>> BDC (-)Tj EMC (positive advanced solid tumors )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 181.8212 232.9517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 192.8212 232.9517 Tm (Selpercatinib for patients with )Tj ET EMC /Span <>BDC BT /TT3 1 Tf 11 0 0 11 352.955 232.9517 Tm (RET)Tj ET EMC /Span <>BDC BT /TT1 1 Tf /Span<>> BDC 11 0 0 11 374.955 232.9517 Tm (-)Tj EMC (fusion positive tumors)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 181.8212 221.9517 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 192.8212 221.9517 Tm <003300480050004500550052004f004c005d005800500044004500030049005200550003005300440057004c00480051005700560003005a004c0057004b00030037003000250010002b0003000b0095001400130003005000580057001200300045000c0003005700580050005200550056>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 512.3637 221.9517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 192.6212 210.9517 Tm (and/or)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 181.8212 199.9517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 192.8212 199.9517 Tm (Other therapies are available and can be considered for progressive and/or symptomatic ) Tj ET EMC /Span <>BDC BT 11 0 0 11 192.6212 188.9517 Tm (disease if clinical trials or other systemic therapies are not available or appropriate.) Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 9 0 0 9 629.1246 192.9517 Tm <00470047000f00480048000f1087000f004c004c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 178.2212 177.9517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 185.1284 177.9517 Tm (Best supportive care \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 300.666 177.9517 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 323.2945 177.9517 Tm (NCCN Guidelines for Palliative Care)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 510.3482 177.9517 Tm (\))Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS1 gs q 1 0 0 1 119.9012 432.9901 cm 0 0 m 48.738 0 l S Q q 1 0 0 1 174.1012 432.9901 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 176.0612 351.0498 cm 0 0 m 0 163.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 657.2841 438.8203 cm 0 0 m 68.413 0 l S Q q 1 0 0 1 300.666 350.8203 cm 0 0 m 209.682 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 178.2212 505.9858 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 185.1284 505.9858 Tm (Consider surgical palliation and/or EBRT/SBRT/other local therapies)Tj ET EMC /Span <>BDC BT 9 0 0 9 542.6929 509.9858 Tm (aa )Tj ET EMC /Span <>BDC BT 11 0 0 11 555.2041 505.9858 Tm (when available if symptomatic, )Tj ET EMC /Span <>BDC BT 11 0 0 11 185.4212 494.9858 Tm (or asymptomatic in weight-bearing sites. Embolization prior to surgical resection of bone metastases ) Tj ET EMC /Span <>BDC BT 11 0 0 11 185.4212 483.9858 Tm (should be considered to reduce the risk of hemorrhage.)Tj ET EMC /Span <>BDC BT 11 0 0 11 178.2212 472.9858 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 185.1284 472.9858 Tm (Consider embolization or other interventional procedures as alternatives to surgical resection/EBRT/) Tj ET EMC /Span <>BDC BT 11 0 0 11 185.4212 461.9858 Tm (IMRT in select cases.)Tj ET EMC /Span <>BDC BT 11 0 0 11 178.2212 450.9858 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 185.1284 450.9858 Tm (Consider intravenous bisphosphonate or denosumab.)Tj ET EMC /Span <>BDC BT 9 0 0 9 468.1045 454.9858 Tm (hh)Tj ET EMC /Span <>BDC BT 11 0 0 11 178.2212 439.9858 Tm <9520>Tj ET EMC /Span <>BDC BT -0.003 Tw 11 0 0 11 185.1284 439.9858 Tm [(Disease monitoring )1.1 (may be )0.5 (appropriate )0.5 (in )0.7 (asymptomatic patients with )1 (indolent )1.2 (disease.)]TJ ET EMC /Span <>BDC BT 0 Tw 9 0 0 9 643.818 443.9858 Tm (dd )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs -0.003 Tw 11 0 0 11 657.284 439.9858 Tm (\(See FOLL-6\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 0 Tw 11 0 0 11 178.2211 428.9858 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 185.1284 428.9858 Tm (Consider systemic therapy)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 181.8211 417.9858 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 192.8211 417.9858 Tm (For progressive and/or symptomatic disease, consider lenvatinib \(preferred\) or sorafenib.) Tj ET EMC /Span <>BDC BT 9 0 0 9 661.6747 421.9858 Tm (cc)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 181.8212 406.9858 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 192.8212 406.9858 Tm (Larotrectinib or entrectinib for patients with )Tj ET EMC /Span <>BDC BT /TT3 1 Tf 11 0 0 11 424.4496 406.9858 Tm (NTRK)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 455.0004 406.9858 Tm ( gene fusion)Tj /Span<>> BDC (-)Tj EMC (positive advanced solid tumors.)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 181.8212 395.9858 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 192.8212 395.9858 Tm (Selpercatinib for patients with )Tj ET EMC /Span <>BDC BT /TT3 1 Tf 11 0 0 11 352.955 395.9858 Tm (RET)Tj ET EMC /Span <>BDC BT /TT1 1 Tf /Span<>> BDC 11 0 0 11 374.955 395.9858 Tm (-)Tj EMC (fusion positive tumors)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 181.8212 384.9858 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 192.8212 384.9858 Tm <003300480050004500550052004f004c005d005800500044004500030049005200550003005300440057004c00480051005700560003005a004c0057004b00030037003000250010002b0003000b0095001400130003005000580057001200300045000c0003005700580050005200550056>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 181.8212 373.9858 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 192.8212 373.9858 Tm (Other therapies are available and can be considered for progressive and/or symptomatic disease if ) Tj ET EMC /Span <>BDC BT 11 0 0 11 192.6212 362.9858 Tm (clinical trials or other systemic therapies are not available or appropriate.) Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 9 0 0 9 575.9293 366.9858 Tm <00470047000f00480048000f1087>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 178.2212 351.9858 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 185.1284 351.9858 Tm (Best supportive care \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 300.666 351.9858 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 323.2944 351.9858 Tm (NCCN Guidelines for Palliative Care)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 510.3481 351.9858 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 23.7612 428.9858 Tm (Bone metastases)Tj ET EMC endstream endobj 395 0 obj 18094 endobj %% Contents for page 31 %% Original object ID: 63 0 396 0 obj << /Length 397 0 R >> stream Q q BT /Xi29 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 397 0 obj 245 endobj %% Original object ID: 385 0 398 0 obj [ 2382 0 R 2383 0 R 2384 0 R 2385 0 R 2386 0 R 2387 0 R 2388 0 R 2389 0 R 2390 0 R 2391 0 R 2392 0 R 2393 0 R ] endobj %% Contents for page 32 %% Original object ID: 64 0 399 0 obj << /Length 400 0 R >> stream q endstream endobj 400 0 obj 2 endobj %% Contents for page 32 %% Original object ID: 386 0 401 0 obj << /Length 402 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Hürthle Cell Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 23.7374 514.3517 Tm [(FNA)54.3 ( )]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.7374 502.3517 Tm [(RESUL)74.2 (TS)]TJ ET EMC /Span <>BDC BT 11 0 0 11 126.3534 514.3517 Tm [(DIAGNOSTIC)17.2 ( )]TJ ET EMC /Span <>BDC BT 11 0 0 11 126.3534 502.3517 Tm (PROCEDURES)Tj ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 299.1934 514.3517 Tm [(PRIMAR)36.8 (Y)35.5 ( )0.6 (TREA)73.9 (TMENT)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 96.48 394.9202 cm 0 0 m 0 -45.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 23.544 348.8103 cm 0 0 m 62.353 0 l S Q /Span <>BDC BT /GS0 gs 0 Tc 0 Tw 11 0 0 11 23.544 385.9759 Tm (Hürthle cell)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 373.9759 Tm (neoplasm)Tj ET EMC /Span <>BDC BT 9 0 0 9 74.8917 377.9759 Tm (a)Tj ET EMC /Span <>BDC BT 11 0 0 11 79.897 373.9759 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 361.9759 Tm (\(Bethesda IV\))Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 23.544 349.9759 Tm (See THYR-3)Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 124 295.0399 cm 0 0 m 0 153.88 l S Q q 1 0 0 1 276.36 448.9202 cm 0 0 m 0 -153.88 l S Q /Span <>BDC BT 0 0 0 scn 11 0 0 11 126.16 439.9759 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 133.0672 439.9759 Tm (Thyroid and neck )Tj ET EMC /Span <>BDC BT 11 0 0 11 133.36 427.9759 Tm (ultrasound \(including )Tj ET EMC /Span <>BDC BT 11 0 0 11 133.36 415.9759 Tm (central and lateral )Tj ET EMC /Span <>BDC BT 11 0 0 11 133.36 403.9759 Tm (compartments\), if not )Tj ET EMC /Span <>BDC BT 11 0 0 11 133.36 391.9759 Tm (previously done)Tj ET EMC /Span <>BDC BT 11 0 0 11 126.16 379.9759 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 133.0672 379.9759 Tm (CT/MRI with contrast for )Tj ET EMC /Span <>BDC BT 11 0 0 11 133.36 367.9759 Tm (locally advanced disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 133.36 355.9759 Tm (or vocal cord paresis)Tj ET EMC /Span <>BDC BT 9 0 0 9 244.0206 359.9759 Tm (b)Tj ET EMC /Span <>BDC BT 11 0 0 11 126.16 343.9759 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 133.0672 343.9759 Tm (Consider evaluation )Tj ET EMC /Span <>BDC BT 11 0 0 11 133.36 331.9759 Tm (of vocal cord mobility )Tj ET EMC /Span <>BDC BT 11 0 0 11 133.36 319.9759 Tm (\(ultrasound, mirror )Tj ET EMC /Span <>BDC BT 11 0 0 11 133.36 307.9759 Tm [(indirect laryngoscopy)74.6 (, or )]TJ ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 133.36 295.9759 Tm <00bf004500480055005200530057004c00460003004f00440055005c0051004a00520056004600520053005c000c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 261.713 299.9759 Tm (c)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 98 371.98 cm 0 0 m 17.938 0 l S Q q 1 0 0 1 121.4 371.98 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 296.5 487 cm 0 0 m 0 -230.04 l S Q EMC /Artifact <>BDC q 1 0 0 1 277.68 371.98 cm 0 0 m 12.538 0 l S Q q 1 0 0 1 295.68 371.98 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 459.9735 487.576 cm 0 0 m 0 -93.88 l S Q /Span <>BDC BT 11 0 0 11 299 478.6317 Tm [(T)74.4 (otal thyroidectomy if )]TJ ET EMC /Span <>BDC BT 11 0 0 11 299 466.6317 Tm [(invasive cancer)54.5 (, metastatic )]TJ ET EMC /Span <>BDC BT 11 0 0 11 299 454.6317 Tm (disease, or patient preference )Tj ET EMC /Span <>BDC BT 11 0 0 11 299 442.6317 Tm (Perform therapeutic neck)Tj ET EMC /Span <>BDC BT 11 0 0 11 431.6553 442.6317 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 299 430.6317 Tm (dissection of involved)Tj ET EMC /Span <>BDC BT 11 0 0 11 414.5215 430.6317 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 299 418.6317 Tm (compartments for clinically )Tj ET EMC /Span <>BDC BT 11 0 0 11 299 406.6317 Tm (apparent/biopsy-proven )Tj ET EMC /Span <>BDC BT 11 0 0 11 299 394.6317 Tm (disease)Tj ET EMC /Span <>BDC BT 11 0 0 11 299 327.3517 Tm (or)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 474.9815 419.6496 cm 0 0 m -14.455 20.986 l -0.156 41.958 l S Q q 1 0 0 1 478.08 415.1513 cm 0 0 m -1.876 7.222 l -6.079 4.327 l h f Q q 1 0 0 1 477.903 466.1203 cm 0 0 m -6.059 -4.356 l -1.842 -7.231 l h f Q EMC /Span <>BDC BT 11 0 0 11 481.16 469.7299 Tm (Benign)Tj ET EMC /Span <>BDC BT 11 0 0 11 481.16 408.4666 Tm (Hürthle cell)Tj ET EMC /Span <>BDC BT 11 0 0 11 481.16 396.4666 Tm (carcinoma)Tj ET EMC /Span <>BDC BT 9 0 0 9 536.1869 400.4666 Tm (e)Tj ET EMC /Artifact <>BDC q 1 0 0 1 525.7189 473.7339 cm 0 0 m 140.579 0 l S Q q 1 0 0 1 671.76 473.7339 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 556.286 406.4708 cm 0 0 m 110.012 0 l S Q q 1 0 0 1 671.76 406.4708 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 672.2599 412 cm 0 0 m 0 -120.6 l S Q EMC /Span <>BDC BT 11 0 0 11 299 260.0717 Tm (Lobectomy/isthmusectomy)Tj ET EMC /Artifact <>BDC q 1 0 0 1 460.6331 201.3146 cm 0 0 m -16.09 62.761 l -0.058 125.521 l S Q q 1 0 0 1 461.9896 196.0235 cm 0 0 m 0.73 7.426 l -4.213 6.159 l h f Q q 1 0 0 1 461.9267 332.1282 cm 0 0 m -4.208 -6.163 l 0.737 -7.426 l h f Q q 1 0 0 1 444.4514 264.058 cm 0 0 m 9.183 0 l S Q q 1 0 0 1 459.0966 264.058 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 557.5686 346.0142 cm 0 0 m 7.418 0 l S Q q 1 0 0 1 570.4486 346.0142 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 567.92 264.0759 cm 0 0 m 7.418 0 l S Q q 1 0 0 1 580.8 264.0759 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 468.8112 191.2317 Tm (Benign)Tj ET EMC /Artifact <>BDC q 1 0 0 1 511.032 195.2359 cm 0 0 m 64.306 0 l S Q q 1 0 0 1 580.8 195.2359 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 574.7643 348.01 Tm (Completion of )Tj ET EMC /Span <>BDC BT 11 0 0 11 574.7643 336.01 Tm (thyroidectomy)Tj ET EMC /Artifact <>BDC q 1 0 0 1 656.84 346.0142 cm 0 0 m 9.458 0 l S Q q 1 0 0 1 671.76 346.0142 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 672.8566 456.7939 cm 0 0 m 0 33.88 l S Q /Span <>BDC BT 11 0 0 11 675.0166 481.7299 Tm (Levothyroxine )Tj ET EMC /Span <>BDC BT 11 0 0 11 675.0166 469.7299 Tm (therapy to keep )Tj ET EMC /Span <>BDC BT 11 0 0 11 675.0166 457.7299 Tm (TSH normal)Tj ET EMC /Span <>BDC BT 9 0 0 9 736.7466 461.7299 Tm (f)Tj ET EMC 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 675.0166 358.5303 cm 0 0 m 91.706 0 l S Q q 1 0 0 1 675.0166 346.5303 cm 0 0 m 58.679 0 l S Q q 1 0 0 1 675.0166 334.5303 cm 0 0 m 47.051 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 675.0166 359.6958 Tm (See Postsurgical )Tj ET EMC /Span <>BDC BT 11 0 0 11 675.0166 347.6958 Tm (Evaluation )Tj ET EMC /Span <>BDC BT 11 0 0 11 675.0166 335.6958 Tm [(\(HÜRT)54.8 (-2\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 722.0674 335.6958 Tm ( )Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 581.32 247.1357 cm 0 0 m 0 57.88 l S Q /Span <>BDC BT 11 0 0 11 583.48 296.0717 Tm (Completion of )Tj ET EMC /Span <>BDC BT 11 0 0 11 583.48 284.0717 Tm (thyroidectomy )Tj ET EMC /Span <>BDC BT 11 0 0 11 583.48 272.0717 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 583.48 260.0717 Tm (Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 583.48 248.0717 Tm (monitoring)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 644.68 258.4318 cm 0 0 m 22.618 0 l S Q q 1 0 0 1 672.76 258.4318 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 672.8566 175.4875 cm 0 0 m 0 105.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 682.2166 175.258 cm 0 0 m 47.051 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 675.0166 272.4235 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 681.9238 272.4235 Tm (Consider )Tj ET EMC /Span <>BDC BT 11 0 0 11 682.2166 260.4235 Tm (levothyroxine )Tj ET EMC /Span <>BDC BT 11 0 0 11 682.2166 248.4235 Tm (therapy to keep )Tj ET EMC /Span <>BDC BT 11 0 0 11 682.2166 236.4235 Tm (TSH low or )Tj ET EMC /Span <>BDC BT 11 0 0 11 682.2166 224.4235 Tm (normal)Tj ET EMC /Span <>BDC BT 9 0 0 9 718.8904 228.4235 Tm (f)Tj ET EMC /Span <>BDC BT 11 0 0 11 675.0166 212.4235 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 681.9238 212.4235 Tm (See Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 682.2166 200.4235 Tm (Monitoring and )Tj ET EMC /Span <>BDC BT 11 0 0 11 682.2166 188.4235 Tm (Maintenance )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 682.2166 176.4235 Tm [(\(HÜRT)54.8 (-6\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 583.48 197.2317 Tm (Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 583.48 185.2317 Tm (monitoring)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 661.24 297.0441 cm 0 0 m 5.058 0 l S Q q 1 0 0 1 671.76 297.0441 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 29.5212 74.3964 cm 0 0 m 202.666 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 8 0 0 8 23.7612 144.456 Tm (a)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 141.456 Tm [(The diagnosis)-0.7 ( of Hürthle cel)-0.6 (l carcinoma requires evidenc)-2 (e of either vascular or capsular invasion, which cannot be determined by FNA.) ]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 133.456 Tm (b)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 130.456 Tm [(Use of iodina)-0.8 (ted contrast is required for optimal cervical i)-1.6 (maging using CT)109.8 (; potential delay in RAI treatment will not cause harm.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 123.456 Tm (c)Tj ET EMC /Span <>BDC BT /Span<>> BDC 9 0 0 9 27.7612 123.456 Tm ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 119.456 Tm [(V)55.2 (ocal cord mobility may be examined in patients with abn)-1.7 (ormal voice, surgical history involving the recurrent laryngeal or vagus nerves, invasive disease, or bulky ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 108.456 Tm (disease of the central neck.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 100.456 Tm (d)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm [(Minimally inva)-0.6 (sive HCC is characterized as an encapsula)-1.9 (ted tumor with microscopic capsular invasion andwithout vascular invasion. ) ]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 89.456 Tm (e)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 86.456 Tm [(Also known as oxyphilic, on)-0.8 (cocytic, or follicular carcinoma)-1.2 (, oncocytic type.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 78.456 Tm (f)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 75.456 Tm [(See Principle)-0.8 (s of )18.2 (TSH Suppression \(THYR-A\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 232.1873 75.456 Tm (.)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 727.3779 23.544 Tm [<48dc5254>72.8 (-)35 (1)]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 643.68 195.2359 cm 0 0 m 22.618 0 l S Q q 1 0 0 1 671.76 195.2359 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 466.6512 317.074 cm 0 0 m 0 57.88 l S Q q 1 0 0 1 555.4128 374.9543 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 468.8112 366.01 Tm (Invasive cancer )Tj ET EMC /Span <>BDC BT 11 0 0 11 468.8112 354.01 Tm (\(widely invasive )Tj ET EMC /Span <>BDC BT 11 0 0 11 468.8112 342.01 Tm (or encapsulated )Tj ET EMC /Span <>BDC BT 11 0 0 11 468.8112 330.01 Tm (angioinvasive )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 468.8112 318.01 Tm <005a004c0057004b000300950017000300590048005600560048004f0056000c0003>Tj ET EMC q 1 0 0 1 466.6512 229.1357 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 567.7617 299.0161 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 468.8112 290.0717 Tm (Encapsulated )Tj ET EMC /Span <>BDC BT 11 0 0 11 468.8112 278.0717 Tm (angioinvasive )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 468.8112 266.0717 Tm <005a004c0057004b0003001f0017000300590048005600560048004f0056>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 468.8112 254.0717 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 468.8112 242.0717 Tm (Minimally invasive )Tj ET EMC /Span <>BDC BT 11 0 0 11 468.8112 230.0717 Tm (HCC)Tj ET EMC /Span <>BDC BT 9 0 0 9 492.6427 234.0717 Tm (d)Tj ET EMC endstream endobj 402 0 obj 17428 endobj %% Contents for page 32 %% Original object ID: 65 0 403 0 obj << /Length 404 0 R >> stream Q q BT /Xi30 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 404 0 obj 245 endobj %% Original object ID: 388 0 405 0 obj [ 2394 0 R 2395 0 R 2396 0 R 2397 0 R 2398 0 R 2399 0 R 2400 0 R 2401 0 R 2402 0 R 2403 0 R 2404 0 R 2405 0 R ] endobj %% Contents for page 33 %% Original object ID: 66 0 406 0 obj << /Length 407 0 R >> stream q endstream endobj 407 0 obj 2 endobj %% Contents for page 33 %% Original object ID: 389 0 408 0 obj << /Length 409 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Hürthle Cell Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 727.3864 23.544 Tm [<48dc5254>72.9 (-)35.2 (2)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 402.3 481.3357 cm 0 0 m 0 21.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 472.3077 481.1062 cm 0 0 m 47.051 0 l S Q /Span <>BDC BT /GS0 gs 0 Tc 0 Tw 11 0 0 11 404.46 494.2717 Tm (See Consideration for Initial Postoperative )Tj ET EMC /Span <>BDC BT 11 0 0 11 404.46 482.2717 Tm (RAI Therapy )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 472.3077 482.2717 Tm [(\(HÜRT)54.8 (-3\))]TJ ET EMC q 1 0 0 1 29.5212 107.3964 cm 0 0 m 202.666 0 l S Q q 1 0 0 1 29.5212 74.3964 cm 0 0 m 245.474 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 8 0 0 8 23.7612 111.456 Tm (f)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 108.456 Tm [(See Principle)-0.8 (s of )18.2 (TSH Suppression \(THYR-A\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 232.1872 108.456 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 100.456 Tm (g)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm [(For bulky)74.2 (, locoregional, visc)-1 (erally invasive disease or rap)-1.9 (id progression, refer to high)]TJ /Span<>> BDC (-)Tj EMC (volume multidisciplinary institution, including radiation oncology referral.) Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 89.456 Tm (h)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 86.456 Tm [(If considering)-0.7 ( dosimetry)]TJ ET EMC /Span <>BDC BT 8 0 0 8 135.1218 89.456 Tm ( )Tj ET EMC /Span <>BDC BT 10 0 0 10 137.3445 86.456 Tm [(iodi)-0.6 (ne)]TJ /Span<>> BDC (-)Tj EMC (131)Tj ET EMC /Span <>BDC BT 8 0 0 8 184.0486 89.456 Tm ( )Tj ET EMC /Span <>BDC BT 10 0 0 10 186.2712 86.456 Tm [(is the preferred agent)-0.9 (.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 78.456 Tm (i)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 75.456 Tm (See )Tj ET EMC /Span <>BDC BT 10 0 0 10 50.0925 75.456 Tm [(Principle)-0.8 (s of Radiation )-0.7 (and RAI )18.1 (Therapy \(THYR)]TJ /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 274.9949 75.456 Tm (.)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 0.035 Tc -0.051 Tw 11 0 0 11 23.7374 514.8317 Tm [(POSTSURGICAL)35.7 ( EV)74.1 (ALUA)73.9 (TION)17.2 ( )]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 68.1445 436.7917 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 427.8474 Tm (Gross )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 415.8474 Tm (residual )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 403.8474 Tm (disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 391.8474 Tm (in neck)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 166.4944 379.2518 cm 0 0 m -14.598 34.6 l -0.15 69.192 l S Q q 1 0 0 1 168.6177 374.2192 cm 0 0 m -0.375 7.453 l -5.077 5.469 l h f Q q 1 0 0 1 168.4491 453.4838 cm 0 0 m -5.057 -5.487 l -0.348 -7.454 l h f Q EMC /Span <>BDC BT 11 0 0 11 136.1 459.3159 Tm (Resectable)Tj ET EMC /Span <>BDC BT 11 0 0 11 136.1 356.2389 Tm (Unresectable)Tj ET EMC /Span <>BDC BT 9 0 0 9 205.1884 360.2389 Tm (g)Tj ET EMC /Artifact <>BDC q 1 0 0 1 200.8667 463.32 cm 0 0 m 12.178 0 l S Q q 1 0 0 1 218.5067 463.32 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 219.5067 465.3159 Tm (Resect, if)Tj ET EMC /Span <>BDC BT 11 0 0 11 219.5067 453.3159 Tm (possible)Tj ET EMC /Artifact <>BDC q 1 0 0 1 283.7047 453.4893 cm 0 0 m -9.897 9.831 l -0.119 19.642 l S Q q 1 0 0 1 287.58 449.64 cm 0 0 m -3.177 6.752 l -6.773 3.131 l h f Q q 1 0 0 1 287.4411 476.9999 cm 0 0 m -6.757 -3.166 l -3.143 -6.768 l h f Q EMC /Span <>BDC BT 11 0 0 11 290.58 486.8963 Tm (No gross )Tj ET EMC /Span <>BDC BT 11 0 0 11 290.58 474.8963 Tm (residual disease)Tj ET EMC /Artifact <>BDC q 1 0 0 1 376.78 484.9005 cm 0 0 m 18.458 0 l S Q q 1 0 0 1 400.7 484.9005 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 290.58 443.4963 Tm (Gross residual)Tj ET EMC /Span <>BDC BT 11 0 0 11 367.6122 443.4963 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 290.58 431.4963 Tm ( disease)Tj ET EMC /Artifact <>BDC q 1 0 0 1 328.3282 426.1899 cm 0 0 m 0 -13.428 l S Q q 1 0 0 1 328.3282 407.2997 cm 0 0 m 2.552 7.012 l -2.552 7.012 l h f Q EMC 10 M q 1 0 0 1 233.0336 313.3029 cm 0 0 m 0 93.88 l S Q q 1 0 0 1 372.093 407.1833 cm 0 0 m 0 -93.88 l S Q /Span <>BDC BT 11 0 0 11 235.1936 398.239 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 242.1008 398.239 Tm (TSH + Tg measurement )Tj ET EMC /Span <>BDC BT 11 0 0 11 367.2984 398.239 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 386.239 Tm (+ antithyroglobulin )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 374.239 Tm (antibodies \(6\22612 wks )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 362.239 Tm (postoperatively\))Tj ET EMC /Span <>BDC BT 11 0 0 11 235.1936 350.239 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 242.1008 350.239 Tm (Iodine)Tj /Span<>> BDC (-)Tj EMC (123 or iodine)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 242.3936 338.239 Tm (131)Tj ET EMC /Span <>BDC BT 9 0 0 9 260.7466 342.239 Tm (h )Tj ET EMC /Span <>BDC BT 11 0 0 11 268.7447 338.239 Tm (total body )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 326.239 Tm (radioiodine imaging)Tj ET EMC /Span <>BDC BT 9 0 0 9 346.899 330.239 Tm (h)Tj ET EMC /Span <>BDC BT 11 0 0 11 352.3965 326.239 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 242.3936 314.239 Tm (\(category 2B\))Tj ET EMC q 1 0 0 1 386.98 381.1219 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 453.86 427.0022 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 11 0 0 11 389.14 418.0579 Tm (Suspected )Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 406.0579 Tm (or proven )Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 394.0579 Tm (inadequate )Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 382.0579 Tm (RAI uptake)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 454.7145 404.0621 cm 0 0 m 3.503 0 l S Q q 1 0 0 1 463.68 404.0621 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 463.54 375.1219 cm 0 0 m 0 57.88 l S Q /Span <>BDC BT -0.002 Tw 11 0 0 11 465.7 424.0579 Tm [(Monitoring )1.1 (of residual disease)]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 465.7 412.0579 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 400.0579 Tm (Consider)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 388.0579 Tm (EBRT/IMRT if disease is )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 376.0579 Tm (threatening vital structures)Tj ET EMC /Span <>BDC BT 9 0 0 9 607.513 380.0579 Tm (i)Tj ET EMC q 1 0 0 1 386.98 272.1316 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 449.02 342.0119 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT 11 0 0 11 389.14 333.0676 Tm (Adequate )Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 321.0676 Tm (RAI uptake)Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 309.0676 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 297.0676 Tm (No RAI )Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 285.0676 Tm (imaging )Tj ET EMC /Span <>BDC BT 11 0 0 11 389.14 273.0676 Tm (performed)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 449.568 307.0718 cm 0 0 m 7.786 0 l S Q q 1 0 0 1 462.816 307.0718 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 463.54 278.1316 cm 0 0 m 0 57.88 l S Q /Span <>BDC BT 11 0 0 11 465.7 327.0676 Tm <9520>Tj ET EMC /Span <>BDC BT -0.025 Tw 11 0 0 11 472.6072 327.0676 Tm [(Radioiodine )1.1 (treatment \(preferred\))]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 465.7 315.0676 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 472.6072 315.0676 Tm (Post-treatment iodine)Tj /Span<>> BDC (-)Tj EMC (131 whole )Tj ET EMC /Span <>BDC BT 11 0 0 11 472.9 303.0676 Tm (body imaging)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 291.0676 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 472.6072 291.0676 Tm (TSH)Tj /Span<>> BDC (-)Tj EMC (stimulated Tg)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 279.0676 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 472.6072 279.0676 Tm (Consider EBRT/IMRT)Tj ET EMC /Span <>BDC BT 9 0 0 9 583.2195 283.0676 Tm (i)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 649.734 436.5004 cm 0 0 m 0 -325.764 l S Q EMC /Artifact <>BDC q 1 0 0 1 650.234 273.6185 cm 0 0 m 13.904 0 l S Q q 1 0 0 1 669.6 273.6185 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 82.9944 384.9113 cm 0 0 m 0 57.88 l S Q q 1 0 0 1 151.2539 442.7917 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT 11 0 0 11 85.1544 433.8474 Tm (Cross)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 85.1544 421.8474 Tm (sectional )Tj ET EMC /Span <>BDC BT 11 0 0 11 85.1544 409.8474 Tm (CT or MRI )Tj ET EMC /Span <>BDC BT 11 0 0 11 85.1544 397.8474 Tm (of neck with )Tj ET EMC /Span <>BDC BT 11 0 0 11 85.1544 385.8474 Tm (contrast)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 68.9821 413.8515 cm 0 0 m 6.416 0 l S Q q 1 0 0 1 80.86 413.8515 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 133.94 158.9217 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 238.6992 228.802 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT 11 0 0 11 136.1 219.8577 Tm (For viscerally )Tj ET EMC /Span <>BDC BT -0.021 Tw 11 0 0 11 136.1 207.8577 Tm (invasive disease or )Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 136.1 195.8577 Tm (rapid progression, )Tj ET EMC /Span <>BDC BT 11 0 0 11 136.1 183.8577 Tm (upfront EBRT/)Tj ET EMC /Span <>BDC BT 11 0 0 11 136.1 171.8577 Tm (IMRT may be most )Tj ET EMC /Span <>BDC BT 11 0 0 11 136.1 159.8577 Tm (appropriate)Tj ET EMC /Span <>BDC BT 9 0 0 9 196.6107 163.8577 Tm (i)Tj ET EMC q 1 0 0 1 260.0336 158.9217 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 428.3356 228.802 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT 11 0 0 11 262.1936 219.8577 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 269.1008 219.8577 Tm (TSH + Tg measurement )Tj ET EMC /Span <>BDC BT 11 0 0 11 394.7199 219.8577 Tm ( )Tj ET EMC /Span <>BDC BT -0.026 Tw 11 0 0 11 269.3936 207.8577 Tm [(+ )0.6 (antithyroglobulin )1.5 (antibodies )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 269.3936 195.8577 Tm (\(6\22612 wks postoperatively\))Tj ET EMC /Span <>BDC BT 11 0 0 11 262.1936 183.8577 Tm <9520>Tj ET EMC /Span <>BDC BT -0.002 Tw 11 0 0 11 269.1008 183.8577 Tm (Iodine)Tj /Span<>> BDC (-)Tj EMC (123 or iodine)Tj /Span<>> BDC (-)Tj EMC (131)Tj ET EMC /Span <>BDC BT 0 Tw 9 0 0 9 394.9764 187.8577 Tm (h )Tj ET EMC /Span <>BDC BT 11 0 0 11 402.9564 183.8577 Tm (total )Tj ET EMC /Span <>BDC BT 11 0 0 11 269.3936 171.8577 Tm (body radioiodine imaging)Tj ET EMC /Span <>BDC BT 9 0 0 9 403.2305 175.8577 Tm (h )Tj ET EMC /Span <>BDC BT 11 0 0 11 269.3936 159.8577 Tm (\(category 2B\))Tj ET EMC q 1 0 0 1 463.54 212.5079 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 526.6968 258.3882 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 11 0 0 11 465.7 249.4439 Tm (Suspected )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 237.4439 Tm (or proven )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 225.4439 Tm (inadequate )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 213.4439 Tm (RAI uptake)Tj ET EMC q 1 0 0 1 463.54 116.4269 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 525.58 186.3072 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT 11 0 0 11 465.7 177.3629 Tm (Adequate )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 165.3629 Tm (RAI uptake)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 153.3629 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 141.3629 Tm (No RAI )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 129.3629 Tm (imaging )Tj ET EMC /Span <>BDC BT 11 0 0 11 465.7 117.3629 Tm (performed)Tj ET EMC q 1 0 0 1 542.7543 200.5079 cm 0 0 m 0 69.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 544.9142 200.2784 cm 0 0 m 47.051 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 544.9142 261.4439 Tm (Monitoring of )Tj ET EMC /Span <>BDC BT 11 0 0 11 544.9142 249.4439 Tm (residual disease)Tj ET EMC /Span <>BDC BT 11 0 0 11 630.5187 249.4439 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 544.9142 237.4439 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 544.9142 225.4439 Tm (Consider )Tj ET EMC /Span <>BDC BT -0.011 Tw 11 0 0 11 544.9142 213.4439 Tm (systemic therapy )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 0 Tw 11 0 0 11 544.9142 201.4439 Tm (\()Tj ET EMC /Span <>BDC BT 11 0 0 11 548.5773 201.4439 Tm (H)Tj ET EMC /Span <>BDC BT 11 0 0 11 556.5212 201.4439 Tm Tj ET EMC /Span <>BDC BT 11 0 0 11 564.465 201.4439 Tm (RT)Tj /Span<>> BDC 1.278 0 Td (-)Tj EMC (8)Tj ET EMC /Span <>BDC BT 11 0 0 11 588.3019 201.4439 Tm (\))Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 542.7542 110.4269 cm 0 0 m 0 81.88 l S Q /Span <>BDC BT 0 0 0 scn 11 0 0 11 544.9142 183.3629 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 551.8214 183.3629 Tm (Radioiodine )Tj ET EMC /Span <>BDC BT 11 0 0 11 552.1142 171.3629 Tm (treatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 552.1142 159.3629 Tm (\(preferred\))Tj ET EMC /Span <>BDC BT 9 0 0 9 607.7372 163.3629 Tm (i)Tj ET EMC /Span <>BDC BT 11 0 0 11 544.9142 147.3629 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 551.8214 147.3629 Tm (Post-treatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 552.1142 135.3629 Tm (iodine)Tj /Span<>> BDC (-)Tj EMC (131 whole )Tj ET EMC /Span <>BDC BT 11 0 0 11 552.1142 123.3629 Tm (body imaging)Tj ET EMC /Span <>BDC BT 11 0 0 11 544.9142 111.3629 Tm <9520>Tj ET EMC /Span <>BDC BT -0.005 Tw 11 0 0 11 551.8214 111.3629 Tm (TSH)Tj /Span<>> BDC (-)Tj EMC (stimulated Tg)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 527.349 151.3671 cm 0 0 m 9.493 0 l S Q q 1 0 0 1 542.304 151.3671 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 241.0537 193.8619 cm 0 0 m 12.178 0 l S Q q 1 0 0 1 258.6937 193.8619 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 527.349 235.4481 cm 0 0 m 9.493 0 l S Q q 1 0 0 1 542.304 235.4481 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 174.2401 350.5601 cm 0 0 m 0 -112.202 l S Q q 1 0 0 1 174.2401 232.8964 cm 0 0 m 2.552 7.012 l -2.552 7.012 l h f Q EMC /Artifact <>BDC q 1 0 0 1 211.0736 360.2431 cm 0 0 m 13.108 0 l S Q q 1 0 0 1 229.6433 360.2431 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 382.8782 347.8062 cm 0 0 m -10.447 12.437 l -0.12 24.856 l S Q q 1 0 0 1 386.3914 343.6237 cm 0 0 m -2.556 7.011 l -6.464 3.728 l h f Q q 1 0 0 1 386.2506 376.8624 cm 0 0 m -6.445 -3.76 l -2.521 -7.023 l h f Q EMC /Artifact <>BDC q 1 0 0 1 455.5942 164.9936 cm 0 0 m -25.336 28.868 l -0.271 57.719 l S Q q 1 0 0 1 459.1972 160.8882 cm 0 0 m -2.708 6.954 l -6.543 3.587 l h f Q q 1 0 0 1 458.9054 226.8355 cm 0 0 m -6.525 -3.62 l -2.673 -6.967 l h f Q EMC /Span <>BDC BT 0 Tw 11 0 0 11 23.544 500.912 Tm (No gross residual )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 488.912 Tm (disease in neck)Tj ET EMC /Artifact <>BDC q 1 0 0 1 123.6872 498.9162 cm 0 0 m 271.551 0 l S Q q 1 0 0 1 400.7 498.9162 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 670.817 232.6782 cm 0 0 m 0 81.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 679.8842 268.4487 cm 0 0 m 67.273 0 l S Q q 1 0 0 1 680.1769 256.4487 cm 0 0 m 82.484 0 l S Q q 1 0 0 1 680.1769 244.4487 cm 0 0 m 69.685 0 l S Q q 1 0 0 1 680.1769 232.4487 cm 0 0 m 47.051 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 672.9769 305.6142 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 679.8842 305.6142 Tm (Suppress )Tj ET EMC /Span <>BDC BT 11 0 0 11 680.1769 293.6142 Tm (TSH with )Tj ET EMC /Span <>BDC BT 11 0 0 11 680.1769 281.6142 Tm (levothyroxine)Tj ET EMC /Span <>BDC BT 9 0 0 9 751.6984 285.6142 Tm (f)Tj ET EMC /Span <>BDC BT 11 0 0 11 672.9769 269.6142 Tm <9520>Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 679.8842 269.6142 Tm (See Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 680.1769 257.6142 Tm (Monitoring and )Tj ET EMC /Span <>BDC BT 11 0 0 11 680.1769 245.6142 Tm (Maintenance )Tj ET EMC /Span <>BDC BT 11 0 0 11 680.1769 233.6142 Tm [(\(HÜRT)54.8 (-6\))]TJ ET EMC endstream endobj 409 0 obj 22660 endobj %% Contents for page 33 %% Original object ID: 67 0 410 0 obj << /Length 411 0 R >> stream Q q BT /Xi31 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 411 0 obj 245 endobj %% Original object ID: 391 0 412 0 obj [ 2406 0 R 2407 0 R 2408 0 R 2409 0 R 2410 0 R 2411 0 R 2412 0 R 2413 0 R 2414 0 R 2415 0 R ] endobj %% Contents for page 34 %% Original object ID: 68 0 413 0 obj << /Length 414 0 R >> stream q endstream endobj 414 0 obj 2 endobj %% Contents for page 34 %% Original object ID: 392 0 415 0 obj << /Length 416 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Hürthle Cell Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 727.3858 23.544 Tm [<48dc5254>72.9 (-)35.1 (3)]TJ ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 23.7374 514.3517 Tm [(CLINICOP)74.1 (A)73.9 (THOLOGIC)17.3 ( )0.6 (F)55.2 (ACT)18.1 (ORS)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 9 0 0 9 205.1568 518.3517 Tm (j)Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 270.72 500.1874 cm 0 0 m 0 -93.88 l S Q /Span <>BDC BT 11 0 0 11 23.544 491.2431 Tm (RAI not typically recommended \(if all present\):)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 479.2431 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 479.2431 Tm <002f00440055004a004800560057000300530055004c005000440055005c0003005700580050005200550003001f0015000300460050>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.544 467.2431 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 467.2431 Tm (Intrathyroidal)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 455.2431 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 455.2431 Tm (No vascular invasion)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 443.2431 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 443.2431 Tm (Clinical N0)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 431.2431 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 431.2431 Tm (No detectable anti-Tg antibodies)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 419.2431 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 419.2431 Tm <0033005200560057005200530048005500440057004c0059004800030058005100560057004c00500058004f004400570048004700030037004a0003001f001400030051004a00120050002f>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 242.8458 423.2431 Tm (k)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 407.2431 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 407.2431 Tm (Negative postoperative ultrasound, if done)Tj ET EMC /Span <>BDC BT 9 0 0 9 253.5396 411.2431 Tm (l)Tj ET EMC q 1 0 0 1 636.56 436.3071 cm 0 0 m 0 33.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 638.72 436.0776 cm 0 0 m 69.679 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 638.72 461.2431 Tm (RAI not typically )Tj ET EMC /Span <>BDC BT 11 0 0 11 638.72 449.2431 Tm (indicated)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 638.72 437.2431 Tm (\()Tj ET EMC /Span <>BDC BT 11 0 0 11 642.3831 437.2431 Tm [(See HÜRT)54.7 (-6)]TJ ET EMC /Span <>BDC BT 11 0 0 11 704.7361 437.2431 Tm (\))Tj ET EMC q 1 0 0 1 638.72 296.1044 cm 0 0 m 69.679 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 638.72 321.2699 Tm (RAI being )Tj ET EMC /Span <>BDC BT 11 0 0 11 638.72 309.2699 Tm (considered )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 638.72 297.2699 Tm (\()Tj ET EMC /Span <>BDC BT 11 0 0 11 642.3831 297.2699 Tm [(See HÜRT)54.7 (-4)]TJ ET EMC /Span <>BDC BT 11 0 0 11 704.7361 297.2699 Tm (\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 0.035 Tc -0.017 Tw 11 0 0 11 300.9934 514.3517 Tm [(CONSIDERA)73.9 (TION)17.3 ( )0.6 (FOR)17.2 ( )0.6 (INITIAL)35.7 ( )0.6 (POST)18.1 (OPERA)73.9 (TIVE)17.4 ( )0.6 (USE)17.5 ( )0.6 (OF)17.6 ( )0.6 (RAI)17.6 ( )]TJ ET EMC /Span <>BDC BT 11 0 0 11 300.9934 502.3517 Tm [(AFTER)17.2 ( )0.6 (T)18.1 (OT)74.2 (AL)35.6 ( )0.7 (THYROIDECT)18.1 (OMY)]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 274.16 453.2473 cm 0 0 m 350.538 0 l S Q q 1 0 0 1 630.16 453.2473 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 274.16 353.6563 cm 0 0 m 20.458 0 l S Q q 1 0 0 1 300.08 353.6563 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 274.16 273.7801 cm 0 0 m 350.538 0 l S Q q 1 0 0 1 630.16 273.7801 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 219.4267 Tm (Known or suspected distant metastases at presentation)Tj ET EMC /Artifact <>BDC q 1 0 0 1 320.4 223.4308 cm 0 0 m 282.258 0 l S Q q 1 0 0 1 608.12 223.4308 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 268.5892 394.5965 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT 11 0 0 11 23.544 385.6522 Tm (RAI selectively recommended \(if any present\):)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 373.6522 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 373.6522 Tm (Largest primary tumor 2\2264 cm)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 361.6522 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 361.6522 Tm (Minor vascular invasion)Tj ET EMC /Span <>BDC BT 9 0 0 9 155.7696 365.6522 Tm (d)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 349.6522 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 349.6522 Tm (Cervical lymph node metastases)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 337.6522 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 337.6522 Tm <0033005200560057005200530048005500440057004c0059004800030058005100560057004c00500058004f004400570048004700030037004a0003001f001800b10014001300030051004a00120050002f>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 261.1988 341.6522 Tm (k)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 325.6522 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 325.6522 Tm (Microscopic positive margins)Tj ET EMC q 1 0 0 1 304.24 312.7162 cm 0 0 m 0 81.88 l S Q q 1 0 0 1 576.6 394.5965 cm 0 0 m 0 -81.88 l S Q /Span <>BDC BT 11 0 0 11 306.4 385.6522 Tm (RAI ablation is recommended when the )Tj ET EMC /Span <>BDC BT 11 0 0 11 306.4 373.6522 Tm (combination of individual clinical factors \(such as )Tj ET EMC /Span <>BDC BT 11 0 0 11 306.4 361.6522 Tm [(the size of the primary tumor)55.6 (, histology)75.2 (, degree )]TJ ET EMC /Span <>BDC BT 11 0 0 11 306.4 349.6522 Tm (of lymphatic invasion, lymph node metastases, )Tj ET EMC /Span <>BDC BT 11 0 0 11 306.4 337.6522 Tm (postoperative thyroglobulin, and age at diagnosis\) )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 306.4 325.6522 Tm <0053005500480047004c0046005700560003004400030056004c004a0051004c00bf004600440051005700030055004c0056004e00030052004900030055004800460058005500550048005100460048000f00030047004c005600570044005100570003>Tj ET EMC /Span <>BDC BT 11 0 0 11 306.4 313.6522 Tm <0050004800570044005600570044005600480056000f00030052005500030047004c00560048004400560048>Tj /Span<>> BDC <0010>Tj EMC [<0056005300480046004c00bf0046000300500052005500570044004f004c0057005c>72.9 <0011>]TJ ET EMC q 1 0 0 1 269.0394 308.7201 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.544 299.7758 Tm (RAI recommended \(if any present\):)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 287.7758 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 287.7758 Tm (Gross extrathyroidal extension)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 275.7758 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 275.7758 Tm <00330055004c005000440055005c000300570058005000520055000300210017000300460050>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.544 263.7758 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 263.7758 Tm (Extensive vascular invasion)Tj ET EMC /Span <>BDC BT 9 0 0 9 177.1949 267.7758 Tm (d)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 251.7758 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 251.7758 Tm [<0033005200560057005200530048005500440057004c005900480003>1 <0058005100560057004c00500058004f00440057004800470003>1.5 <0037004a0003>1.6 <0021001800b1001400130003>0.6 <0051004a0012002f>]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 251.3711 255.7758 Tm (k,m)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 239.7758 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 239.7758 Tm <00250058004f004e005c0003005200550003002100180003005300520056004c0057004c005900480003004f005c00500053004b000300510052004700480056>Tj ET EMC 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 701.7869 218.2612 cm 0 0 m 69.679 0 l S Q /Span <>BDC BT /GS0 gs /TT1 1 Tf 11 0 0 11 610.72 219.4267 Tm (Amenable to RAI )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 701.7869 219.4267 Tm (\()Tj ET EMC /Span <>BDC BT 11 0 0 11 705.45 219.4267 Tm [(See HÜRT)54.7 (-5)]TJ ET EMC /Span <>BDC BT 11 0 0 11 767.803 219.4267 Tm (\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 23.544 195.8069 Tm (Gross residual disease not amenable to RAI therapy)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 300.08 199.8111 cm 0 0 m 302.578 0 l S Q q 1 0 0 1 608.12 199.8111 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 610.72 194.6414 cm 0 0 m 62.353 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 610.72 195.807 Tm [(See HÜRT)54.7 (-8)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 8 0 0 8 23.544 166.3872 Tm (d)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 163.3872 Tm [(Minimally inva)-0.6 (sive HCC is characterized as an encapsula)-1.9 (ted tumor with )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 152.3872 Tm (microscopic capsular invasion and without vascular invasion.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 144.3872 Tm (j)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 141.3872 Tm [(A)55.2 ( majority of HCC are non\226i)-0.9 (odine)]TJ /Span<>> BDC (-)Tj EMC [(avid, particularly for hig)-1.9 (h)]TJ /Span<>> BDC (-)Tj EMC (risk disease that )Tj ET EMC /Span <>BDC BT 10 0 0 10 29.304 130.3872 Tm (is negative on iodine)Tj /Span<>> BDC (-)Tj EMC (123/iodine)Tj /Span<>> BDC (-)Tj EMC [(131 imaging. )51.3 (A)55.2 ( negative post)]TJ /Span<>> BDC (-)Tj EMC (therapy scan, )Tj ET EMC /Span <>BDC BT 10 0 0 10 29.304 119.3872 Tm [(especially done without SPECT)109.2 (, will likely miss distant structural disease. If )17.2 (Tg is )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 108.3872 Tm (high and/or pathology is high risk, FDG)Tj /Span<>> BDC (-)Tj EMC [(PET)16.6 ( is indicated.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.544 100.3872 Tm (k)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 97.3872 Tm [(Tg values obtained 6\22612 we)-1.2 (eks after total thyroidectomy)74 (.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.544 89.3872 Tm (l)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 86.3872 Tm [(If preoperative imaging inco)-1.3 (mplete, consider postoperativ)-1.5 (e ultrasound including )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 75.3872 Tm (central and lateral neck components.)Tj ET EMC /Span <>BDC BT 8 0 0 8 400.3914 111.3872 Tm (m )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 409.2781 108.3872 Tm [(Additional cross-sectional imaging \(CT)15.6 ( or MRI of the neck with contrast and )]TJ ET EMC /Span <>BDC BT 10 0 0 10 409.2781 97.3872 Tm [(chest CT)18.1 ( with contrast\) should be considered to rule out the presence of )]TJ ET EMC /Span <>BDC BT 10 0 0 10 409.2781 86.3872 Tm (significant normal thyroid remnant or gross residual disease and to detect ) Tj ET EMC /Span <>BDC BT 10 0 0 10 409.2781 75.3872 Tm (clinically significant distant metastases.)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 586.08 353.6563 cm 0 0 m 38.618 0 l S Q q 1 0 0 1 630.16 353.6563 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 634.8 364.5081 cm 0 0 m 0 -102.468 l S Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 645.3043 152.3282 cm 0 0 m 119.055 0 l S Q q 1 0 0 1 559.5028 140.3282 cm 0 0 m 168.706 0 l S Q q 1 0 0 1 559.5028 128.3282 cm 0 0 m 48.877 0 l S Q /Span <>BDC BT /GS0 gs /TT1 1 Tf 11 0 0 11 559.5028 165.4937 Tm (For general principles related to RAI )Tj ET EMC /Span <>BDC BT -0.006 Tw 11 0 0 11 559.5028 153.4937 Tm [(therapy)73.9 (, see the )]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 645.3043 153.4937 Tm (Principles of Radiation )Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 559.5028 141.4937 Tm (and Radioactive Iodine Therapy )Tj ET EMC /Span <>BDC BT 11 0 0 11 559.5028 129.4937 Tm (\(THYR)Tj /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC 0 0 0 SCN 1 w 4 M /GS0 gs 556.123 126.114 211.616 50.768 re S endstream endobj 416 0 obj 16749 endobj %% Contents for page 34 %% Original object ID: 69 0 417 0 obj << /Length 418 0 R >> stream Q q BT /Xi32 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 418 0 obj 245 endobj %% Original object ID: 394 0 419 0 obj [ 2416 0 R 2417 0 R 2418 0 R 2419 0 R 2420 0 R 2421 0 R 2422 0 R 2423 0 R 2424 0 R 2425 0 R 2426 0 R ] endobj %% Contents for page 35 %% Original object ID: 70 0 420 0 obj << /Length 421 0 R >> stream q endstream endobj 421 0 obj 2 endobj %% Contents for page 35 %% Original object ID: 395 0 422 0 obj << /Length 423 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Hürthle Cell Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 727.3779 23.544 Tm [<48dc5254>72.8 (-)35 (4)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 101.551 353.4399 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 344.4956 Tm (6\22612 weeks )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 332.4956 Tm (post-)Tj ET EMC /Span <>BDC BT 11 0 0 11 50.4263 332.4956 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 320.4956 Tm (thyroidectomy)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 101.6794 336.4998 cm 0 0 m 11.697 0 l S Q q 1 0 0 1 118.8382 336.4998 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 120.24 289.5596 cm 0 0 m 0 93.88 l S Q q 1 0 0 1 224.0472 383.4399 cm 0 0 m 0 -93.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 122.4 289.3301 cm 0 0 m 69.679 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 122.4 374.4956 Tm (Clinicopathologic )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 122.4 362.4956 Tm [<00bf00510047004c0051004a00560003>66.1 <005300550052005000530057004c0051004a0003>]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 122.4 350.4956 Tm (consideration for )Tj ET EMC /Span <>BDC BT 11 0 0 11 122.4 338.4956 Tm (RAI, without gross )Tj ET EMC /Span <>BDC BT 11 0 0 11 122.4 326.4956 Tm (residual disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 122.4 314.4956 Tm (or known distant )Tj ET EMC /Span <>BDC BT 11 0 0 11 122.4 302.4956 Tm (metastasis)Tj ET EMC /Span <>BDC BT 11 0 0 11 179.2691 302.4956 Tm ( )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 122.4 290.4956 Tm (\()Tj ET EMC /Span <>BDC BT 11 0 0 11 126.0631 290.4956 Tm [(See HÜRT)54.7 (-3)]TJ ET EMC /Span <>BDC BT 11 0 0 11 188.4161 290.4956 Tm (\))Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 670.5266 293.3051 cm 0 0 m 0 93.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 679.5937 377.0756 cm 0 0 m 67.273 0 l S Q q 1 0 0 1 679.8865 365.0756 cm 0 0 m 82.484 0 l S Q q 1 0 0 1 679.8865 353.0756 cm 0 0 m 69.685 0 l S Q q 1 0 0 1 679.8865 341.0756 cm 0 0 m 47.051 0 l S Q q 1 0 0 1 738.5604 305.0756 cm 0 0 m 26.292 0 l S Q q 1 0 0 1 679.8865 293.0756 cm 0 0 m 45.214 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 672.6865 378.2411 Tm <9520>Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 679.5937 378.2411 Tm (See Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 679.8865 366.2411 Tm (Monitoring and )Tj ET EMC /Span <>BDC BT 11 0 0 11 679.8865 354.2411 Tm (Maintenance )Tj ET EMC /Span <>BDC BT 11 0 0 11 679.8865 342.2411 Tm [(\(HÜRT)54.8 (-6\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 672.6865 330.2411 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 679.5937 330.2411 Tm (Levothyroxine )Tj ET EMC /Span <>BDC BT 11 0 0 11 679.8865 318.2411 Tm (to appropriate )Tj ET EMC /Span <>BDC BT 11 0 0 11 679.8865 306.2411 Tm (TSH target )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 738.5604 306.2411 Tm (\(See )Tj ET EMC /Span <>BDC BT 11 0 0 11 679.8865 294.2411 Tm (THYR-A\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 0.035 Tc -0.017 Tw 11 0 0 11 23.7373 514.3517 Tm [(RAI)17.5 ( )0.7 (BEING)17.6 ( )0.6 (CONSIDERED)17.2 ( )0.6 (BASED)17.3 ( )0.6 (ON)17.2 ( )0.6 (CLINICOP)74.1 (A)73.9 (THOLOGIC)17.2 ( )0.6 (FEA)73.9 (TURES)]TJ ET EMC /GS1 gs q 1 0 0 1 29.5212 162.3964 cm 0 0 m 245.474 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 0 Tc 0 Tw 8 0 0 8 23.7612 166.456 Tm (i)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 163.456 Tm (See )Tj ET EMC /Span <>BDC BT 10 0 0 10 50.0925 163.456 Tm [(Principle)-0.8 (s of Radiation )-0.7 (and RAI )18.1 (Therapy \(THYR)]TJ /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 274.9949 163.456 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 155.456 Tm (n)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 152.456 Tm (Even in the absence of thyroid bed uptake RAI treatment m)Tj (ay be considered. If higher than expected uptake \(residual thyroid uptake or distant metastasis\) change ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 141.456 Tm [(dose accordingly)72.8 (.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 133.456 Tm (o)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 130.456 Tm [(A)55.2 ( false)]TJ /Span<>> BDC (-)Tj EMC [(negative pretreatment scan is possible and should)-1.8 ( not prevent the use of RAI if otherwise indicated.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 122.456 Tm (q)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 119.456 Tm [(Alternatively)73.7 (, low-dose iodin)-1.3 (e)]TJ /Span<>> BDC (-)Tj EMC [(131 \(1\2263 mCi\) may be used)-1.4 (. )]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 111.456 Tm (r )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 28.648 108.456 Tm (While pre-ablation diagnostic scans in this setting are commonly done at NCCN Member Institutions, the panel recommends \(category 2B\) selective use of pre-ablation ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm [(diagnostic scans based on pathology)71.8 (, postoperative )17.7 (Tg, intraoperative findings, and available imaging studies. Furthermore, dosimetry studies are considered in ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 86.456 Tm (patients at high risk of having RAI-avid distant metastasis. Empiric RAI doses may exceed maximum tolerable activity levels in patients with decreased GFR. Dialysis ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 75.456 Tm (patients require special handling.)Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 333.2402 340.081 cm 0 0 m 0 81.88 l S Q q 1 0 0 1 428.5235 421.9613 cm 0 0 m 0 -81.88 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 335.4002 413.017 Tm (Consider )Tj ET EMC /Span <>BDC BT 11 0 0 11 335.4002 401.017 Tm (pretreatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 335.4002 389.017 Tm (iodine)Tj /Span<>> BDC (-)Tj EMC (123 whole )Tj ET EMC /Span <>BDC BT 11 0 0 11 335.4002 377.017 Tm (body diagnostic )Tj ET EMC /Span <>BDC BT 11 0 0 11 335.4002 365.017 Tm (imaging)Tj ET EMC /Span <>BDC BT 9 0 0 9 377.5687 369.017 Tm (n,o)Tj ET EMC /Span <>BDC BT 11 0 0 11 391.0643 365.017 Tm ( with )Tj ET EMC /Span <>BDC BT 11 0 0 11 335.4002 353.017 Tm (TSH stimulation)Tj ET EMC /Span <>BDC BT 9 0 0 9 419.1248 357.017 Tm (i)Tj ET EMC /Span <>BDC BT 11 0 0 11 335.4002 341.017 Tm (\(category 2B\))Tj ET EMC /Span <>BDC BT 9 0 0 9 405.6971 345.017 Tm (q,r)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 310.7602 381.0212 cm 0 0 m 15.178 0 l S Q q 1 0 0 1 331.4002 381.0212 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 450.7459 352.081 cm 0 0 m 0 57.88 l S Q q 1 0 0 1 540.3139 409.9613 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT -0.032 Tw 11 0 0 11 452.9059 401.017 Tm (Resect clinically )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 0 Tw 11 0 0 11 452.9059 389.017 Tm <0056004c004a0051004c00bf00460044005100570003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 452.9059 377.017 Tm (structural )Tj ET EMC /Span <>BDC BT 11 0 0 11 452.9059 365.017 Tm (disease if )Tj ET EMC /Span <>BDC BT 11 0 0 11 452.9059 353.017 Tm (possible )Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 430.3635 381.0212 cm 0 0 m 13.08 0 l S Q q 1 0 0 1 448.9059 381.0212 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 545.4977 381.0212 cm 0 0 m 8.978 0 l S Q q 1 0 0 1 559.9377 381.0212 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 242.84 358.081 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 308.9202 403.9613 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 11 0 0 11 245 395.017 Tm (RAI therapy )Tj ET EMC /Span <>BDC BT 11 0 0 11 245 383.017 Tm (indicated )Tj ET EMC /Span <>BDC BT 11 0 0 11 245 371.017 Tm (based on )Tj ET EMC /Span <>BDC BT 11 0 0 11 245 359.017 Tm (pathology)Tj ET EMC q 1 0 0 1 242.84 279.0901 cm 0 0 m 0 33.88 l S Q q 1 0 0 1 335.799 312.9704 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 11 0 0 11 245 304.0261 Tm (RAI therapy not )Tj ET EMC /Span <>BDC BT 11 0 0 11 245 292.0261 Tm (indicated based )Tj ET EMC /Span <>BDC BT 11 0 0 11 245 280.0261 Tm (on pathology)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 339.1779 296.0303 cm 0 0 m 323.938 0 l S Q q 1 0 0 1 668.5779 296.0303 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 561.7778 322.081 cm 0 0 m 0 117.88 l S Q q 1 0 0 1 650.5887 439.9613 cm 0 0 m 0 -117.88 l S Q /Span <>BDC BT 11 0 0 11 563.9377 431.017 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 570.845 431.017 Tm (RAI therapy )Tj ET EMC /Span <>BDC BT 11 0 0 11 571.1378 419.017 Tm (for remnant )Tj ET EMC /Span <>BDC BT 11 0 0 11 571.1378 407.017 Tm (ablation or )Tj ET EMC /Span <>BDC BT 11 0 0 11 571.1378 395.017 Tm (adjuvant )Tj ET EMC /Span <>BDC BT 11 0 0 11 571.1378 383.017 Tm (therapy)Tj ET EMC /Span <>BDC BT 9 0 0 9 610.8731 387.017 Tm (i)Tj ET EMC /Span <>BDC BT 11 0 0 11 563.9377 371.017 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 570.845 371.017 Tm (Post)Tj /Span<>> BDC (-)Tj EMC (treatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 571.1378 359.017 Tm (iodine)Tj /Span<>> BDC (-)Tj EMC (131 )Tj ET EMC /Span <>BDC BT 11 0 0 11 571.1378 347.017 Tm (imaging )Tj ET EMC /Span <>BDC BT 11 0 0 11 571.1378 335.017 Tm (\(whole body )Tj ET EMC /Span <>BDC BT 11 0 0 11 571.1378 323.017 Tm (RAI scan\))Tj ET EMC /Span <>BDC BT 9 0 0 9 621.8731 327.017 Tm (i)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 652.4286 381.0212 cm 0 0 m 10.796 0 l S Q q 1 0 0 1 668.6866 381.0212 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC /GS0 gs q 1 0 0 1 238.9185 316.0184 cm 0 0 m -13.994 20.481 l -0.151 40.948 l S Q q 1 0 0 1 242 311.5085 cm 0 0 m -1.849 7.229 l -6.063 4.35 l h f Q q 1 0 0 1 241.8278 361.4911 cm 0 0 m -6.042 -4.379 l -1.815 -7.238 l h f Q EMC endstream endobj 423 0 obj 14255 endobj %% Contents for page 35 %% Original object ID: 71 0 424 0 obj << /Length 425 0 R >> stream Q q BT /Xi33 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 425 0 obj 245 endobj %% Original object ID: 397 0 426 0 obj [ 2427 0 R 2428 0 R 2429 0 R 2430 0 R 2431 0 R 2432 0 R 2433 0 R 2434 0 R 2435 0 R 2436 0 R 2437 0 R ] endobj %% Contents for page 36 %% Original object ID: 72 0 427 0 obj << /Length 428 0 R >> stream q endstream endobj 428 0 obj 2 endobj %% Contents for page 36 %% Original object ID: 398 0 429 0 obj << /Length 430 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Hürthle Cell Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 727.3779 23.544 Tm [<48dc5254>72.8 (-)35 (5)]TJ ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 23.7374 514.3517 Tm [(KNOWN)17.2 ( )0.6 (OR)17.3 ( )0.6 (SUSPECTED)17.3 ( )0.6 (DIST)74.3 (ANT)17.6 ( )0.6 (MET)74.2 (AST)74.2 (A)73.9 (TIC)17.3 ( )0.6 (DISEASE)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 105.9983 363.6947 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 354.7504 Tm (6\22612 weeks )Tj ET EMC /Span <>BDC BT 11 0 0 11 87.1539 354.7504 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 342.7504 Tm (post-)Tj ET EMC /Span <>BDC BT 11 0 0 11 50.4263 342.7504 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 330.7504 Tm (thyroidectomy)Tj ET EMC q 1 0 0 1 122.0314 311.8144 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 199.0236 381.6947 cm 0 0 m 0 -69.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 124.1914 311.5848 cm 0 0 m 69.679 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 124.1914 372.7504 Tm (Known or )Tj ET EMC /Span <>BDC BT 11 0 0 11 124.1914 360.7504 Tm (suspected )Tj ET EMC /Span <>BDC BT 11 0 0 11 124.1914 348.7504 Tm (distant )Tj ET EMC /Span <>BDC BT -0.009 Tw 11 0 0 11 124.1914 336.7504 Tm [(metastases )-1.4 (at )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 124.1914 324.7504 Tm (presentation )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 124.1914 312.7504 Tm [(\(See HÜRT)54.7 (-3\))]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS0 gs q 1 0 0 1 107.1949 346.7545 cm 0 0 m 8.178 0 l S Q 0 0 0 scn q 1 0 0 1 120.8348 346.7545 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 200.2202 346.7545 cm 0 0 m 11.818 0 l S Q q 1 0 0 1 217.5002 346.7545 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 218.6968 287.8144 cm 0 0 m 0 117.88 l S Q q 1 0 0 1 332.4558 405.6947 cm 0 0 m 0 -117.88 l S Q /Span <>BDC BT 11 0 0 11 220.8568 396.7504 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 227.764 396.7504 Tm (Appropriate )Tj ET EMC /Span <>BDC BT 11 0 0 11 228.0568 384.7504 Tm (cross-sectional )Tj ET EMC /Span <>BDC BT 11 0 0 11 228.0568 372.7504 Tm (imaging \(CT or MRI )Tj ET EMC /Span <>BDC BT 11 0 0 11 228.0568 360.7504 Tm (with contrast\) of )Tj ET EMC /Span <>BDC BT 11 0 0 11 228.0568 348.7504 Tm (known metastatic )Tj ET EMC /Span <>BDC BT 11 0 0 11 228.0568 336.7504 Tm (foci)Tj ET EMC /Span <>BDC BT 9 0 0 9 247.6129 340.7504 Tm (s)Tj ET EMC /Span <>BDC BT 11 0 0 11 220.8568 324.7504 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 227.764 324.7504 Tm (Resect clinically )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 228.0568 312.7504 Tm <0056004c004a0051004c00bf00460044005100570003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 228.0568 300.7504 Tm (structural disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 228.0568 288.7504 Tm (if possible)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 333.6524 346.7545 cm 0 0 m 13.818 0 l S Q q 1 0 0 1 352.933 346.7545 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 480.4969 313.1124 cm 0 0 m -13.414 33.642 l -0.138 67.277 l S Q q 1 0 0 1 482.52 308.0387 cm 0 0 m -0.227 7.459 l -4.967 5.568 l h f Q q 1 0 0 1 482.3643 385.4704 cm 0 0 m -4.948 -5.586 l -0.201 -7.459 l h f Q EMC /Artifact <>BDC q 1 0 0 1 550.2003 438.4359 cm 0 0 m 10.578 0 l S Q q 1 0 0 1 566.24 438.4359 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 673.98 321.0387 cm 0 0 m 0 93.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 683.0472 404.8092 cm 0 0 m 67.273 0 l S Q q 1 0 0 1 683.34 392.8092 cm 0 0 m 82.484 0 l S Q q 1 0 0 1 683.34 380.8092 cm 0 0 m 69.685 0 l S Q q 1 0 0 1 683.34 368.8092 cm 0 0 m 47.051 0 l S Q q 1 0 0 1 716.9577 332.8092 cm 0 0 m 26.292 0 l S Q q 1 0 0 1 683.34 320.8092 cm 0 0 m 45.214 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 676.14 405.9747 Tm <9520>Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 683.0472 405.9747 Tm (See Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 683.34 393.9747 Tm (Monitoring and )Tj ET EMC /Span <>BDC BT 11 0 0 11 683.34 381.9747 Tm (Maintenance )Tj ET EMC /Span <>BDC BT 11 0 0 11 683.34 369.9747 Tm [(\(HÜRT)54.8 (-6\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 676.14 357.9747 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 683.0472 357.9747 Tm (Levothyroxine )Tj ET EMC /Span <>BDC BT 11 0 0 11 683.34 345.9747 Tm (to appropriate )Tj ET EMC /Span <>BDC BT 11 0 0 11 683.34 333.9747 Tm (target )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 716.9577 333.9747 Tm (\(See )Tj ET EMC /Span <>BDC BT 11 0 0 11 683.34 321.9747 Tm (THYR-A\))Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS0 gs q 1 0 0 1 544.08 294.5219 cm 0 0 m 16.698 0 l S Q 0 0 0 scn q 1 0 0 1 566.24 294.5219 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 566.98 259.5817 cm 0 0 m 0 69.88 l S Q /Span <>BDC BT 11 0 0 11 569.14 320.5177 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 576.0472 320.5177 Tm (Consider )Tj ET EMC /Span <>BDC BT 11 0 0 11 576.34 308.5177 Tm (RAI adjuvant )Tj ET EMC /Span <>BDC BT 11 0 0 11 576.34 296.5177 Tm (therapy)Tj ET EMC /Span <>BDC BT 11 0 0 11 569.14 284.5177 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 576.0472 284.5177 Tm (Post-treatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 576.34 272.5177 Tm (imaging \(whole )Tj ET EMC /Span <>BDC BT 11 0 0 11 576.34 260.5177 Tm (body RAI scan\))Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 657.64 460.4399 cm 0 0 m 0 -199.922 l S Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 29.5212 140.3964 cm 0 0 m 245.474 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 8 0 0 8 23.7612 144.456 Tm (i)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 141.456 Tm (See )Tj ET EMC /Span <>BDC BT 10 0 0 10 50.0925 141.456 Tm [(Principle)-0.8 (s of Radiation )-0.7 (and RAI )18.1 (Therapy \(THYR)]TJ /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 274.9949 141.456 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 133.456 Tm (r )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 28.648 130.456 Tm (While pre-ablation diagnostic scans in this setting are commonly done at NCCN Member Institutions, the panel recommends \(category 2B\) selective use of pre-ablation ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 119.456 Tm [(diagnostic scans based on pathology)71.8 (, postoperative )17.7 (Tg, intraoperative findings, and available imaging studies. Furthermore, dosimetry studies are considered in ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 108.456 Tm (patients at high risk of having RAI-avid distant metastasis. Empiric RAI doses may exceed maximum tolerable activity levels in patients with decreased GFR. Dialysis ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm (patients require special handling.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 89.456 Tm (s)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 86.456 Tm [(T)111 (o evaluate macroscopic me)-0.7 (tastatic foci for potential alte)-0.7 (rative therapies \(such as surgical resection and/or external beam radiation\) to prevent invasion/compression. ) ]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 78.456 Tm (t)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 75.456 Tm [(Thyrotropin alfa may be used for elderly patients for whom prolonged hypothyroidism may be risky) 71.2 (.)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 566.98 415.4957 cm 0 0 m 0 45.88 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 569.14 452.4317 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 576.0472 452.4317 Tm (RAI therapy )Tj ET EMC /Span <>BDC BT 11 0 0 11 569.14 440.4317 Tm <9520>Tj ET EMC /Span <>BDC BT -0.152 Tw 11 0 0 11 576.0472 440.4317 Tm [(Post-treatment )-0.7 ( )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 576.34 428.4317 Tm (imaging \(whole )Tj ET EMC /Span <>BDC BT 11 0 0 11 576.34 416.4317 Tm (body RAI scan\))Tj ET EMC q 1 0 0 1 354.1296 281.8144 cm 0 0 m 0 129.88 l S Q q 1 0 0 1 465.348 411.6947 cm 0 0 m 0 -129.88 l S Q /Span <>BDC BT 11 0 0 11 356.2896 402.7504 Tm (6 weeks following )Tj ET EMC /Span <>BDC BT 11 0 0 11 356.2896 390.7504 Tm (cross)Tj /Span<>> BDC (-)Tj EMC (sectional )Tj ET EMC /Span <>BDC BT 11 0 0 11 356.2896 378.7504 Tm (imaging:)Tj ET EMC /Span <>BDC BT 11 0 0 11 356.2896 366.7504 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 363.1968 366.7504 Tm (Consider 24)Tj /Span<>> BDC (-)Tj EMC (hour )Tj ET EMC /Span <>BDC BT 11 0 0 11 363.4896 354.7504 Tm (urine iodine)Tj ET EMC /Span <>BDC BT 11 0 0 11 356.2896 342.7504 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 363.1968 342.7504 Tm (Pretreatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 363.4896 330.7504 Tm (radioiodine )Tj ET EMC /Span <>BDC BT -0.048 Tw 11 0 0 11 363.4896 318.7504 Tm [(diagnostic )1 (imaging )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 363.4896 306.7504 Tm (\(iodine)Tj /Span<>> BDC (-)Tj EMC (123 or )Tj ET EMC /Span <>BDC BT 11 0 0 11 363.4896 294.7504 Tm (iodine)Tj /Span<>> BDC (-)Tj EMC (131\) with )Tj ET EMC /Span <>BDC BT 11 0 0 11 363.4896 282.7504 Tm (TSH stimulation)Tj ET EMC /Span <>BDC BT 9 0 0 9 447.2142 286.7504 Tm [(i,r)55.3 (,t)]TJ ET EMC q 1 0 0 1 481.7553 397.4957 cm 0 0 m 0 81.88 l S Q q 1 0 0 1 549.3285 479.376 cm 0 0 m 0 -81.88 l S Q /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 483.9153 470.4317 Tm <00260052005100bf00550050004800470003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 483.9153 458.4317 Tm (radioiodine)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 483.9153 446.4317 Tm (avid tumor)Tj ET EMC /Span <>BDC BT 11 0 0 11 483.9153 434.4317 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 483.9153 422.4317 Tm (Thyroid )Tj ET EMC /Span <>BDC BT 11 0 0 11 483.9153 410.4317 Tm (remnant )Tj ET EMC /Span <>BDC BT 11 0 0 11 483.9153 398.4317 Tm (uptake only)Tj ET EMC /Span <>BDC BT 11 0 0 11 483.9153 290.5177 Tm (No uptake)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 658.14 367.9788 cm 0 0 m 8.158 0 l S Q q 1 0 0 1 671.76 367.9788 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC endstream endobj 430 0 obj 14680 endobj %% Contents for page 36 %% Original object ID: 73 0 431 0 obj << /Length 432 0 R >> stream Q q BT /Xi34 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 432 0 obj 245 endobj %% Original object ID: 400 0 433 0 obj [ 2438 0 R 2439 0 R 2440 0 R 2441 0 R 2442 0 R 2443 0 R 2444 0 R ] endobj %% Contents for page 37 %% Original object ID: 74 0 434 0 obj << /Length 435 0 R >> stream q endstream endobj 435 0 obj 2 endobj %% Contents for page 37 %% Original object ID: 401 0 436 0 obj << /Length 437 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Hürthle Cell Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q q 1 0 0 1 31.7612 74.3964 cm 0 0 m 171.733 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs 8 0 0 8 23.7612 100.456 Tm (u)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm [(A)55.2 ( subgroup of low-risk patie)-1 (nts may only require an ultras)-1.1 (ound if there is a reasonable suspicion for recurrence. )]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 89.456 Tm (v)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT -0.001 Tw 10 0 0 10 29.5212 86.456 Tm [(In )0.6 (selected )0.5 (patients who may )0.6 (be at )0.6 (higher risk )0.5 (for )0.6 (residua)-0.8 (l/recurrent disease \(eg, )0.5 (N1 patients\), obtain a )0.5 (stimulated )18 (Tg )0.6 (and consider concomitant diagnostic RAI )0.5 (imaging.)]TJ ET EMC /Span <>BDC BT 0 Tw 8 0 0 8 23.7612 78.456 Tm (w )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 31.7612 75.456 Tm (See NCCN Guidelines for Survivorship)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 203.4946 75.456 Tm (.)Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 302.4421 432.5559 cm 0 0 m 0 -189.88 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.5446 423.6116 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4518 423.6116 Tm (Physical examination, TSH and Tg measurement )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 411.6116 Tm (+)Tj /Span<>> BDC ( )Tj EMC (antithyroglobulin antibodies at 6 and 12 mo, then )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 399.6116 Tm (annually if disease-free)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.5446 387.6116 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4518 387.6116 Tm (Periodic neck ultrasound)Tj ET EMC /Span <>BDC BT 9 0 0 9 161.8717 391.6116 Tm (u)Tj ET EMC /Span <>BDC BT 11 0 0 11 167.3693 387.6116 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.5446 375.6116 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4518 375.6116 Tm (Consider TSH-stimulated or TSH-unstimulated )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 363.6116 Tm (Tg measurements using an ultrasensitive )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 351.6116 Tm (assay in patients previously treated with RAI )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 339.6116 Tm (and with negative TSH-suppressed Tg and )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 327.6116 Tm (anti-thyroglobulin antibodies)Tj ET EMC /Span <>BDC BT 9 0 0 9 182.29 331.6116 Tm (v)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.5446 315.6116 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4518 315.6116 Tm (Consider TSH-stimulated radioiodine whole )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 303.6116 Tm (body imaging in high-risk patients, patients with )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 291.6116 Tm (previous RAI-avid metastases, or patients with )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 279.6116 Tm (abnormal Tg levels \(either TSH-suppressed or )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 267.6116 Tm (TSH-stimulated\), stable or rising antithyroglobulin )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 255.6116 Tm (antibodies, or abnormal ultrasound during )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.7446 243.6116 Tm (surveillance)Tj ET EMC /Span <>BDC BT 0.035 Tc -0.035 Tw 11 0 0 11 397.9485 514.3517 Tm (MANAGEMENT)Tj ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 323.2369 405.3517 Tm (NED)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 305.16 409.3559 cm 0 0 m 10.178 0 l S Q q 1 0 0 1 320.8006 409.3559 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 353.5716 409.3559 cm 0 0 m 34.262 0 l S Q q 1 0 0 1 393.2962 409.3559 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 396.0957 344.4157 cm 0 0 m 0 129.88 l S Q q 1 0 0 1 656.2157 474.296 cm 0 0 m 0 -129.88 l S Q 0.75 w q 1 0 0 1 398.2557 464.1862 cm 0 0 m 158.292 0 l S Q /Span <>BDC BT 11 0 0 11 398.2557 465.3517 Tm (Long-term disease monitoring)Tj ET EMC /Span <>BDC BT 9 0 0 9 556.5472 469.3517 Tm (w)Tj ET EMC /Span <>BDC BT 11 0 0 11 398.2557 453.3517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 405.163 453.3517 Tm (Patients treated with iodine)Tj /Span<>> BDC (-)Tj EMC (131 ablation, with )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 405.4557 441.3517 Tm [<0044000300510048004a00440057004c0059004800030058004f00570055004400560052005800510047000f000300560057004c00500058004f004400570048004700030037004a0003001f001500030051004a00120050002f>20.1 <0003>]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 405.4557 429.3517 Tm (\(with negative antithyroglobulin antibodies\), )Tj ET EMC /Span <>BDC BT 11 0 0 11 405.4557 417.3517 Tm (and negative RAI imaging \(if performed\) may )Tj ET EMC /Span <>BDC BT 11 0 0 11 405.4557 405.3517 Tm (be followed by unstimulated thyroglobulin )Tj ET EMC /Span <>BDC BT 11 0 0 11 405.4557 393.3517 Tm (annually and by periodic neck ultrasound. )Tj ET EMC /Span <>BDC BT 11 0 0 11 405.4557 381.3517 Tm (TSH-stimulated testing, or other imaging \(CT )Tj ET EMC /Span <>BDC BT 11 0 0 11 405.4557 369.3517 Tm (or MRI with contrast\) as clinically appropriate, )Tj ET EMC /Span <>BDC BT 11 0 0 11 405.4557 357.3517 Tm (may be considered if clinical suggestion of )Tj ET EMC /Span <>BDC BT 11 0 0 11 405.4557 345.3517 Tm (recurrent disease.)Tj ET EMC /Artifact <>BDC 1 w 4 M /GS1 gs q 1 0 0 1 303.7369 266.98 cm 0 0 m 11.602 0 l S Q q 1 0 0 1 320.8006 266.98 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT /GS0 gs 11 0 0 11 323.2369 268.9759 Tm (Abnormal)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 323.2369 256.9759 Tm <00bf00510047004c0051004a0056>Tj ET EMC 10 M q 1 0 0 1 396.0957 232.0398 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 656.2157 301.9201 cm 0 0 m 0 -69.88 l S Q 0.75 w q 1 0 0 1 398.2557 291.8103 cm 0 0 m 95.938 0 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 398.2557 292.9758 Tm (Additional workup)Tj ET EMC /Span <>BDC BT 11 0 0 11 398.2557 280.9758 Tm (If iodine)Tj /Span<>> BDC (-)Tj EMC (131 imaging negative and stimulated )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 398.2557 268.9758 Tm <0037004a00030021001500b1001800030051004a00120050002f000f00030046005200510056004c0047004800550003004400470047004c0057004c005200510044004f0003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 398.2557 256.9758 Tm (nonradioiodine imaging \(eg, central and lateral )Tj ET EMC /Span <>BDC BT 11 0 0 11 398.2557 244.9758 Tm (neck compartments ultrasound, neck CT with )Tj ET EMC /Span <>BDC BT 11 0 0 11 398.2557 232.9758 Tm (contrast, chest CT with contrast, PET/CT\) )Tj ET EMC /Artifact <>BDC 1 w 4 M /GS1 gs q 1 0 0 1 375.68 266.98 cm 0 0 m 14.606 0 l S Q q 1 0 0 1 395.7484 266.98 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 685.148 392.4157 cm 0 0 m 0 33.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 687.308 392.1862 cm 0 0 m 69.679 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 687.308 417.3517 Tm (Recurrent )Tj ET EMC /Span <>BDC BT 11 0 0 11 687.308 405.3517 Tm (disease )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 730.7279 405.3517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 687.308 393.3517 Tm [(\(See HÜRT)54.7 (-7\))]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 656.2557 409.3559 cm 0 0 m 19.762 0 l S Q 0 0 0 scn q 1 0 0 1 681.4803 409.3559 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 658.2557 266.98 cm 0 0 m 17.762 0 l S Q q 1 0 0 1 681.4803 266.98 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 685.148 226.0399 cm 0 0 m 0 81.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 687.308 273.8103 cm 0 0 m 69.679 0 l S Q q 1 0 0 1 687.308 225.8103 cm 0 0 m 69.679 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 687.308 298.9759 Tm (Recurrent )Tj ET EMC /Span <>BDC BT 11 0 0 11 687.308 286.9759 Tm (disease )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 730.7279 286.9759 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 687.308 274.9759 Tm [(\(See HÜRT)54.7 (-7\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 687.308 262.9759 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 687.308 250.9759 Tm (Metastatic )Tj ET EMC /Span <>BDC BT 11 0 0 11 687.308 238.9759 Tm (disease )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 730.7279 238.9759 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 687.308 226.9759 Tm [(\(See HÜRT)54.7 (-8\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 0.035 Tc -0.035 Tw 11 0 0 11 322.9297 514.3517 Tm (FINDINGS)Tj ET EMC /Span <>BDC BT 11 0 0 11 727.3779 23.544 Tm [<48dc5254>72.8 (-)35 (6)]TJ ET EMC /Span <>BDC BT -0.054 Tw 11 0 0 11 23.738 514.3517 Tm [(DISEASE)17.5 ( )-36.4 (MONIT)18.1 (ORING)17.6 ( )0.7 (AND)17.3 ( )]TJ ET EMC /Span <>BDC BT -0.035 Tw 11 0 0 11 23.738 502.3517 Tm (MAINTENANCE)Tj ET EMC endstream endobj 437 0 obj 12644 endobj %% Contents for page 37 %% Original object ID: 75 0 438 0 obj << /Length 439 0 R >> stream Q q BT /Xi35 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 439 0 obj 245 endobj %% Original object ID: 403 0 440 0 obj [ 2445 0 R 2446 0 R 2447 0 R 2448 0 R 2449 0 R 2450 0 R 2451 0 R 2452 0 R 2453 0 R ] endobj %% Contents for page 38 %% Original object ID: 76 0 441 0 obj << /Length 442 0 R >> stream q endstream endobj 442 0 obj 2 endobj %% Contents for page 38 %% Original object ID: 404 0 443 0 obj << /Length 444 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Hürthle Cell Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 727.3779 23.544 Tm [<48dc5254>72.8 (-)35 (7)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 188.3 502.5183 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 493.574 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 493.574 Tm [(Stimulated Tg 1\22610 ng/mL)19 ( )]TJ ET EMC /Span <>BDC BT 11 0 0 11 30.744 481.574 Tm (and negative imaging)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 469.574 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 469.574 Tm (Non-resectable tumors)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 457.574 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 457.574 Tm (Non-radioiodine responsive)Tj ET EMC /Span <>BDC BT 9 0 0 9 175.9166 461.574 Tm (x)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 189.36 479.5782 cm 0 0 m 5.237 0 l S Q q 1 0 0 1 200.0588 479.5782 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 205.14 475.574 Tm (Suppress TSH with levothyroxine)Tj ET EMC /Span <>BDC BT 9 0 0 9 379.953 479.574 Tm (f)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 304.3517 Tm (Locoregional )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 292.3517 Tm (recurrence)Tj ET EMC 10 M q 1 0 0 1 202.98 225.4157 cm 0 0 m 0 153.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 326.7322 261.1862 cm 0 0 m 236.581 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 205.14 370.3517 Tm (Surgery \(preferred\) if resectable)Tj ET EMC /Span <>BDC BT 9 0 0 9 372.6483 374.3517 Tm (aa)Tj ET EMC /Span <>BDC BT 11 0 0 11 205.14 358.3517 Tm (and/or )Tj ET EMC /Span <>BDC BT 11 0 0 11 205.14 346.3517 Tm (Radioiodine treatment,)Tj ET EMC /Span <>BDC BT 9 0 0 9 324.3192 350.3517 Tm (i )Tj ET EMC /Span <>BDC BT 11 0 0 11 329.3202 346.3517 Tm (if radioiodine imaging positive )Tj ET EMC /Span <>BDC BT 11 0 0 11 205.14 334.3517 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 205.14 322.3517 Tm (Disease monitoring for non-progressive disease that is stable and distant from critical structures) Tj ET EMC /Span <>BDC BT 11 0 0 11 205.14 310.3517 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 205.14 298.3517 Tm (For select patients with unresectable, non\226radioiodine-avid, and progressive disease, consider: ) Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 208.74 286.3517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 219.74 286.3517 Tm (EBRT \(IMRT/SBRT\))Tj ET EMC /Span <>BDC BT 9 0 0 9 319.9485 290.3517 Tm (i)Tj ET EMC /Span <>BDC BT 11 0 0 11 322.449 286.3517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 219.54 274.3517 Tm (and/or)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 208.74 262.3517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 219.74 262.3517 Tm (Systemic therapies \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 326.7322 262.3517 Tm [(See T)55.2 (reatment of Metastatic Disease HÜRT)53.6 (-8\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 205.14 250.3517 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 205.14 238.3517 Tm [(For )0.6 (select patients with )0.9 (limited )0.6 (burden )0.8 (nodal )0.9 (disease, consider local )0.6 (therapies when )0.8 (available \(eg, )0.6 (ethanol )]TJ ET EMC /Span <>BDC BT 11 0 0 11 205.14 226.3517 Tm [(ablation, RF)56 (A\))]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.544 179.0558 Tm (Metastatic disease)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 123.84 183.06 cm 0 0 m 70.757 0 l S Q q 1 0 0 1 200.0588 183.06 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 202.98 154.1199 cm 0 0 m 0 57.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 205.14 153.8903 cm 0 0 m 62.353 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 205.14 203.0559 Tm (RAI therapy for iodine)Tj /Span<>> BDC (-)Tj EMC (avid disease)Tj ET EMC /Span <>BDC BT 9 0 0 9 389.1322 207.0559 Tm (i)Tj ET EMC /Span <>BDC BT 11 0 0 11 205.14 191.0559 Tm (and/or)Tj ET EMC /Span <>BDC BT 11 0 0 11 205.14 179.0559 Tm (Local therapies when available)Tj ET EMC /Span <>BDC BT 9 0 0 9 366.536 183.0559 Tm (bb)Tj ET EMC /Span <>BDC BT 11 0 0 11 205.14 167.0559 Tm (and/or)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 205.14 155.0559 Tm [(See HÜRT)54.7 (-8)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 267.493 155.0559 Tm ( if not amenable to RAI)Tj ET EMC /Span <>BDC BT 0.035 Tc -0.017 Tw 11 0 0 11 23.7374 513.86 Tm [(RECURRENT)17.6 ( )0.6 (DISEASE)]TJ ET EMC /GS1 gs q 1 0 0 1 29.304 85.3276 cm 0 0 m 205.444 0 l S Q q 1 0 0 1 29.304 74.3276 cm 0 0 m 245.474 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 0 Tc 0 Tw 8 0 0 8 23.544 89.3872 Tm (f)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.304 86.3872 Tm [(See Principle)-0.8 (s of )18.2 (TSH Suppression \(THYR-A\).)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 8 0 0 8 23.544 78.3872 Tm (i)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.304 75.3872 Tm (See )Tj ET EMC /Span <>BDC BT 10 0 0 10 49.8753 75.3872 Tm [(Principle)-0.8 (s of Radiation )-0.7 (and RAI )18.1 (Therapy \(THYR)]TJ /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 274.7776 75.3872 Tm (.)Tj ET EMC /GS1 gs q 1 0 0 1 406.1834 96.3276 cm 0 0 m 245.474 0 l S Q /Span <>BDC BT /GS0 gs 8 0 0 8 400.4234 199.3872 Tm (x )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 406.6461 196.3872 Tm [(Generally)73.4 (, a tumor is considered iodine-responsive if follow-up iodine)]TJ /Span<>> BDC (-)Tj EMC (123 or )Tj ET EMC /Span <>BDC BT 10 0 0 10 406.6461 185.3872 Tm (low-dose iodine)Tj /Span<>> BDC (-)Tj EMC (131 \(1\2263 mCi\) whole body diagnostic imaging done 6\22612 mo )Tj ET EMC /Span <>BDC BT 10 0 0 10 406.6461 174.3872 Tm (after iodine)Tj /Span<>> BDC (-)Tj EMC (131 treatment is negative or shows decreasing uptake compared to )Tj ET EMC /Span <>BDC BT 10 0 0 10 406.6461 163.3872 Tm (pre-treatment scans. It is recommended to use the same preparation and imaging ) Tj ET EMC /Span <>BDC BT 10 0 0 10 406.6461 152.3872 Tm [(method employed for the pre-treatment scan and therapy)72.2 (. Favorable response )]TJ ET EMC /Span <>BDC BT 10 0 0 10 406.6461 141.3872 Tm (to iodine)Tj /Span<>> BDC (-)Tj EMC (131 treatment is additionally assessed through change in volume of )Tj ET EMC /Span <>BDC BT 10 0 0 10 406.6461 130.3872 Tm (known iodine-concentrated lesions by CT/MRI, and by decreasing unstimulated ) Tj ET EMC /Span <>BDC BT 10 0 0 10 406.6461 119.3872 Tm (or stimulated thyroglobulin levels. )Tj ET EMC /Span <>BDC BT 8 0 0 8 400.4234 111.3872 Tm (z)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 406.1834 108.3872 Tm [(The administered activity of RAI therapy should be adjust)-1.1 (ed for pediatric patients. )]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 406.1834 97.3872 Tm (See )Tj ET EMC /Span <>BDC BT 10 0 0 10 426.7547 97.3872 Tm [(Principles of Radiation and RAI )16.4 (Therapy \(THYR)]TJ /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 651.657 97.3872 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 400.4234 89.3872 Tm (aa )Tj ET EMC /Span <>BDC BT 10 0 0 10 411.5445 86.3872 Tm (Preoperative vocal cord assessment, if central neck recurrence.)Tj ET EMC /Span <>BDC BT 8 0 0 8 400.4234 78.3872 Tm (bb )Tj ET EMC /Span <>BDC BT 10 0 0 10 411.5445 75.3872 Tm [(Ethanol ablation, cryoablation, RF)53.4 (A, etc.)]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 394.14 479.5782 cm 0 0 m 15.651 0 l S Q q 1 0 0 1 415.2533 479.5782 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 417.6 468.638 cm 0 0 m 0 21.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 697.2576 468.4085 cm 0 0 m 69.679 0 l S Q /Span <>BDC BT /GS0 gs /TT1 1 Tf 11 0 0 11 419.76 481.574 Tm (Continue surveillance with unstimulated Tg,)Tj ET EMC /Span <>BDC BT 11 0 0 11 419.76 469.574 Tm (ultrasound, and other imaging as clinically indicated )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 697.2576 469.574 Tm [(\(See HÜRT)54.7 (-6\))]TJ ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 154.0096 442.0401 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 0 0 0 scn 11 0 0 11 23.544 433.0958 Tm <9520>Tj ET EMC /Span <>BDC BT -0.012 Tw 11 0 0 11 30.4512 433.0958 Tm [(Progressively )-0.7 (rising Tg )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 30.744 421.0958 Tm (\(basal or stimulated\))Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 409.0958 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 409.0958 Tm (Scans \(including PET\) )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 397.0958 Tm (negative )Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 154.0773 419.1 cm 0 0 m 40.519 0 l S Q q 1 0 0 1 200.0587 419.1 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 202.98 396.1598 cm 0 0 m 0 45.88 l S Q /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 205.14 433.0958 Tm <0026005200510056004c0047004800550003005500440047004c0052004c00520047004c0051004800030057004b0048005500440053005c0003005a004c0057004b00030095001400130013000300500026004c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 434.2762 437.0958 Tm (z)Tj ET EMC /Span <>BDC BT 11 0 0 11 205.14 421.0958 Tm (and )Tj ET EMC /Span <>BDC BT 11 0 0 11 205.14 409.0958 Tm (Post-treatment iodine)Tj /Span<>> BDC (-)Tj EMC (131 imaging \(category 3\); additional RAI treatments should be limited to patients ) Tj ET EMC /Span <>BDC BT 11 0 0 11 205.14 397.0958 Tm (who responded to previous RAI therapy \(minimum of 6\22612 months between RAI treatments\)) Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 188.64 302.3559 cm 0 0 m 6.058 0 l S Q q 1 0 0 1 200.16 302.3559 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 117.7546 279.4157 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 188.1534 325.296 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 11 0 0 11 119.9146 316.3517 Tm (Consider )Tj ET EMC /Span <>BDC BT 11 0 0 11 119.9146 304.3517 Tm (preoperative )Tj ET EMC /Span <>BDC BT 11 0 0 11 119.9146 292.3517 Tm (iodine total )Tj ET EMC /Span <>BDC BT 11 0 0 11 119.9146 280.3517 Tm (body scan)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 97.744 302.3559 cm 0 0 m 13.731 0 l S Q q 1 0 0 1 116.9373 302.3559 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC endstream endobj 444 0 obj 14771 endobj %% Contents for page 38 %% Original object ID: 77 0 445 0 obj << /Length 446 0 R >> stream Q q BT /Xi36 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 446 0 obj 245 endobj %% Original object ID: 406 0 447 0 obj [ 2454 0 R 2455 0 R 2456 0 R 2457 0 R 2458 0 R 2459 0 R 2460 0 R 2461 0 R 2462 0 R 2463 0 R 2464 0 R 2465 0 R 2466 0 R ] endobj %% Contents for page 39 %% Original object ID: 78 0 448 0 obj << /Length 449 0 R >> stream q endstream endobj 449 0 obj 2 endobj %% Contents for page 39 %% Original object ID: 407 0 450 0 obj << /Length 451 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Hürthle Cell Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 727.3778 23.544 Tm [<48dc5254>72.8 (-)35 (8)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 313.1471 450.9573 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 313.1471 342.9573 cm 0 0 m 0 69.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 315.3071 487.8933 Tm (Unresectable )Tj ET EMC /Span <>BDC BT 11 0 0 11 315.3071 475.8933 Tm (locoregional )Tj ET EMC /Span <>BDC BT 11 0 0 11 315.3071 463.8933 Tm (recurrent/)Tj ET EMC /Span <>BDC BT -0.023 Tw 11 0 0 11 315.3071 451.8933 Tm (persistent disease)Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 315.3071 427.8933 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 315.3071 403.8933 Tm (Soft tissue )Tj ET EMC /Span <>BDC BT 11 0 0 11 315.3071 391.8933 Tm (metastases )Tj ET EMC /Span <>BDC BT 11 0 0 11 315.3071 379.8933 Tm [(\(eg, lung, liver)56.4 (, )]TJ ET EMC /Span <>BDC BT -0.021 Tw 11 0 0 11 315.3071 367.8933 Tm (muscle\) excluding )Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 315.3071 355.8933 Tm (CNS metastases )Tj ET EMC /Span <>BDC BT 11 0 0 11 315.3071 343.8933 Tm (\(see below\))Tj ET EMC /Span <>BDC BT 11 0 0 11 315.3071 219.952 Tm (CNS metastases)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 413.8071 495.9016 cm 0 0 m 0 -151.77 l S Q EMC /Artifact <>BDC q 1 0 0 1 414.3071 402.8975 cm 0 0 m 8.231 0 l S Q q 1 0 0 1 428 402.8975 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 409.407 265.7237 cm 0 0 m 13.131 0 l S Q q 1 0 0 1 428 265.7237 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT /GS0 gs 0.035 Tc -0.017 Tw 11 0 0 11 23.7374 514.3517 Tm [(TREA)73.9 (TMENT)17.6 ( )0.6 (OF)17.6 ( )0.6 (LOCALL)91.8 (Y)35.5 ( )0.6 (RECURRENT)128.4 (,)35.2 ( )37.7 (ADV)74.1 (ANCED)17.3 (,)35.1 ( )37.7 (AND)17.3 (/)17.5 (OR)17.2 ( )0.6 (MET)74.2 (AST)74.2 (A)73.9 (TIC)17.3 ( )0.6 (DISEASE)17.5 ( )0.5 (NOT)17.6 ( )37.7 (AMENABLE)17.5 ( )0.6 (T)18 (O)17.6 ( )0.6 (RAI)17.6 ( )0.6 (THERAPY)]TJ ET EMC 10 M q 1 0 0 1 428.02 289.9573 cm 0 0 m 0 213.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 667.8322 349.7278 cm 0 0 m 89.23 0 l S Q q 1 0 0 1 437.38 337.7278 cm 0 0 m 107.61 0 l S Q q 1 0 0 1 437.38 301.7278 cm 0 0 m 47.051 0 l S Q q 1 0 0 1 552.6249 289.7278 cm 0 0 m 209.682 0 l S Q /Span <>BDC BT /GS0 gs 0 Tc 0 Tw 11 0 0 11 430.18 494.8933 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 437.0872 494.8933 Tm (Consider systemic therapy)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 433.78 482.8933 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 444.78 482.8933 Tm (For progressive and/or symptomatic disease, consider )Tj ET EMC /Span <>BDC BT 11 0 0 11 444.58 470.8933 Tm (lenvatinib \(preferred\))Tj ET EMC /Span <>BDC BT 9 0 0 9 554.6015 474.8933 Tm (bb)Tj ET EMC /Span <>BDC BT 11 0 0 11 565.5966 470.8933 Tm ( or sorafenib.)Tj ET EMC /Span <>BDC BT 9 0 0 9 635.2758 474.8933 Tm (dd,ee)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 433.78 458.8933 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 444.78 458.8933 Tm (Larotrectinib or entrectinib for patients with )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 676.4084 458.8933 Tm (NTRK)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 706.9592 458.8933 Tm ( gene )Tj ET EMC /Span <>BDC BT 11 0 0 11 444.58 446.8933 Tm (fusion)Tj /Span<>> BDC (-)Tj EMC (positive advanced solid tumors.)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 433.78 434.8933 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 444.78 434.8933 Tm (Selpercatinib )Tj ET EMC /Span <>BDC BT 11 0 0 11 516.9138 434.8933 Tm (for patients with )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 604.9138 434.8933 Tm (RET)Tj ET EMC /Span <>BDC BT /TT1 1 Tf /Span<>> BDC 11 0 0 11 626.9138 434.8933 Tm (-)Tj EMC (fusion positive tumors)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 433.78 422.8933 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 444.78 422.8933 Tm <003300480050004500550052004f004c005d005800500044004500030049005200550003005300440057004c00480051005700560003005a004c0057004b00030037003000250010002b0003000b0095001400130003005000580057001200300045000c0003005700580050005200550056>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 433.78 410.8933 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 444.78 410.8933 Tm (Other therapies are available and can be considered for )Tj ET EMC /Span <>BDC BT 11 0 0 11 444.58 398.8933 Tm (progressive and/or symptomatic disease if clinical trials or )Tj ET EMC /Span <>BDC BT 11 0 0 11 444.58 386.8933 Tm (other systemic therapies are not available or appropriate.)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 9 0 0 9 744.1313 390.8933 Tm <1087000f004a004a>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 430.18 374.8933 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 437.0872 374.8933 Tm (Consider resection of distant metastases and/or EBRT \(SBRT/)Tj ET EMC /Span <>BDC BT 11 0 0 11 437.38 362.8933 Tm (IMRT\))Tj ET EMC /Span <>BDC BT 9 0 0 9 467.9254 366.8933 Tm (i)Tj ET EMC /Span <>BDC BT 11 0 0 11 470.4259 362.8933 Tm (/other local therapies)Tj ET EMC /Span <>BDC BT 9 0 0 9 581.0704 366.8933 Tm (bb)Tj ET EMC /Span <>BDC BT 11 0 0 11 592.0656 362.8933 Tm ( when available to metastatic )Tj ET EMC /Span <>BDC BT 11 0 0 11 437.38 350.8933 Tm (lesions if progressive and/or symptomatic. \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 667.8322 350.8933 Tm (For locoregional )Tj ET EMC /Span <>BDC BT 11 0 0 11 437.38 338.8933 Tm [(disease, see HÜRT)54.5 (-7)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 544.9899 338.8933 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 430.18 326.8933 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 437.0872 326.8933 Tm (Disease monitoring is often appropriate in asymptomatic )Tj ET EMC /Span <>BDC BT 11 0 0 11 437.38 314.8933 Tm (patients with indolent disease assuming no brain metastasis.)Tj ET EMC /Span <>BDC BT 9 0 0 9 757.6798 318.8933 Tm (ee)Tj ET EMC /Span <>BDC BT 11 0 0 11 767.6906 314.8933 Tm ( )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 437.38 302.8933 Tm [(\(HÜRT)54.8 (-6\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 430.18 290.8933 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 437.0872 290.8933 Tm (Best supportive care \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 552.6248 290.8933 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 575.2532 290.8933 Tm (NCCN Guidelines for Palliative Care)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 762.3069 290.8933 Tm (\))Tj ET EMC /GS1 gs q 1 0 0 1 29.304 162.3276 cm 0 0 m 202.666 0 l S Q q 1 0 0 1 29.304 151.3276 cm 0 0 m 245.474 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 8 0 0 8 23.544 166.3872 Tm (f)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.304 163.3872 Tm [(See Principle)-0.8 (s of )18.2 (TSH Suppression \(THYR-A\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 231.97 163.3872 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 155.3872 Tm (i)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.304 152.3872 Tm (See )Tj ET EMC /Span <>BDC BT 10 0 0 10 49.8753 152.3872 Tm [(Principle)-0.8 (s of Radiation )-0.7 (and RAI )18.1 (Therapy \(THYR)]TJ /Span<>> BDC (-)Tj EMC (C\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 274.7776 152.3872 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 144.3872 Tm (bb )Tj ET EMC /Span <>BDC BT 10 0 0 10 34.6651 141.3872 Tm [(Ethanol ablation, cryoablation, RF)53.4 (A, etc.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.544 133.3872 Tm (cc )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 33.7667 130.3872 Tm (In a subset of patients \(older than 65 years of age\), lenvatinib showed an ) Tj ET EMC /Span <>BDC BT 10 0 0 10 33.7667 119.3872 Tm (overall survival benefit compared to placebo. Brose MS, et al. J Clin Oncol ) Tj ET EMC /Span <>BDC BT 10 0 0 10 33.7667 108.3872 Tm (2017;35:2692-2699.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 100.3872 Tm (dd )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 34.6651 97.3872 Tm (The decision of whether to use lenvatinib \(preferred\) or sorafenib should ) Tj ET EMC /Span <>BDC BT 10 0 0 10 34.6651 86.3872 Tm (be individualized for each patient based on likelihood of response and )Tj ET EMC /Span <>BDC BT 10 0 0 10 34.6651 75.3872 Tm (comorbidities.)Tj ET EMC /GS1 gs q 1 0 0 1 573.522 151.3276 cm 0 0 m 188.809 0 l S Q q 1 0 0 1 411.2173 140.3276 cm 0 0 m 43.882 0 l S Q /Span <>BDC BT /GS0 gs 8 0 0 8 400.0962 166.3872 Tm (ee )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 411.2173 163.3872 Tm (Kinase inhibitor therapy may not be approriate for patients with stable or ) Tj ET EMC /Span <>BDC BT 10 0 0 10 411.2173 152.3872 Tm (slowly progressive indolent disease. )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 573.522 152.3872 Tm [(See Principles of Kinase Inhibitor )16.4 (Therapy )]TJ ET EMC /Span <>BDC BT 10 0 0 10 411.2173 141.3872 Tm (\(THYR-B\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 455.0991 141.3872 Tm (.)Tj ET EMC /Span <>BDC BT -0.018 Tc 0.018 Tw 8 0 0 8 400.0962 133.3872 Tm [(ff)-17.8 ( )]TJ /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 Tc 0 Tw 10 0 0 10 406.6196 130.3872 Tm (Commercially available small-molecule kinase inhibitors \(such as axitinib, ) Tj ET EMC /Span <>BDC BT 10 0 0 10 406.6196 119.3872 Tm (everolimus, pazopanib, sunitinib, vandetanib, vemurafenib [)Tj ET EMC /Span <>BDC BT /TT3 1 Tf 10 0 0 10 669.5542 119.3872 Tm [(BRAF)18.1 ( )]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 10 0 0 10 698.8218 119.3872 Tm (positive], )Tj ET EMC /Span <>BDC BT 10 0 0 10 406.6196 108.3872 Tm (dabrafenib [)Tj ET EMC /Span <>BDC BT /TT3 1 Tf 10 0 0 10 459.437 108.3872 Tm [(BRAF)18.1 ( )]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 10 0 0 10 488.7046 108.3872 Tm (positive], or cabozantinib [all are category 2A]\) can be )Tj ET EMC /Span <>BDC BT 10 0 0 10 406.6196 97.3872 Tm (considered if clinical trials are not available or appropriate. )Tj ET EMC /Span <>BDC BT 8 0 0 8 400.0962 89.3872 Tm (gg )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 411.2173 86.3872 Tm [(Cytotoxic chemotherapy has been shown to have minimal ef)15.4 (ficacy)74.1 (, although )]TJ ET EMC /Span <>BDC BT 10 0 0 10 411.2173 75.3872 Tm (most studies were small and underpowered. )Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS1 gs q 1 0 0 1 309.5864 231.8103 cm 0 0 m -26.591 107.524 l -0.269 215.044 l S Q q 1 0 0 1 310.8977 226.5079 cm 0 0 m 0.794 7.42 l -4.161 6.195 l h f Q q 1 0 0 1 310.6163 452.16 cm 0 0 m -4.146 -6.204 l 0.811 -7.418 l h f Q EMC /Artifact <>BDC q 1 0 0 1 309.5121 279.7288 cm 0 0 m -25.935 59.605 l -0.265 119.202 l S Q q 1 0 0 1 311.6913 274.7202 cm 0 0 m -0.458 7.448 l -5.138 5.412 l h f Q q 1 0 0 1 311.4078 403.9477 cm 0 0 m -5.118 -5.431 l -0.43 -7.45 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 128.9875 380.2741 cm 0 0 m 0 -81.88 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.544 371.3298 Tm (Structurally )Tj ET EMC /Span <>BDC BT -0.003 Tc 0.003 Tw 11 0 0 11 23.544 359.3298 Tm [(persistent/recurrent)-3 ( )]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 347.3298 Tm (locoregional or )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 335.3298 Tm (distant metastatic )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 323.3298 Tm (disease not )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 311.3298 Tm (amenable to RAI )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 299.3298 Tm (therapy)Tj ET EMC /Span <>BDC BT 11 0 0 11 315.3071 261.7195 Tm (Bone metastases)Tj ET EMC 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 430.18 260.554 cm 0 0 m 62.353 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 430.18 261.7195 Tm [(See HÜRT)54.7 (-9)]TJ ET EMC q 1 0 0 1 430.18 218.7865 cm 0 0 m 62.353 0 l S Q /Span <>BDC BT 11 0 0 11 430.18 219.952 Tm [(See HÜRT)54.7 (-9)]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 406.36 223.9562 cm 0 0 m 16.178 0 l S Q 0 0 0 scn q 1 0 0 1 428 223.9562 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 147.4103 262.3938 cm 0 0 m 0 153.88 l S Q q 1 0 0 1 283.0242 416.2741 cm 0 0 m 0 -153.88 l S Q /Span <>BDC BT 11 0 0 11 149.5703 407.3298 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 156.4775 407.3298 Tm (Continue to suppress )Tj ET EMC /Span <>BDC BT -0.024 Tw 11 0 0 11 156.7703 395.3298 Tm [(TSH with )0.6 (levothyroxine)]TJ ET EMC /Span <>BDC BT 0 Tw 9 0 0 9 277.8672 399.3298 Tm (f)Tj ET EMC /Span <>BDC BT 11 0 0 11 149.5703 383.3298 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 156.4775 383.3298 Tm (For advanced, )Tj ET EMC /Span <>BDC BT 11 0 0 11 156.7703 371.3298 Tm (progressive, or )Tj ET EMC /Span <>BDC BT 11 0 0 11 156.7703 359.3298 Tm (threatening disease, )Tj ET EMC /Span <>BDC BT 11 0 0 11 156.7703 347.3298 Tm (genomic testing to )Tj ET EMC /Span <>BDC BT 11 0 0 11 156.7703 335.3298 Tm (identify actionable )Tj ET EMC /Span <>BDC BT 11 0 0 11 156.7703 323.3298 Tm (mutations \(including )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 156.7703 311.3298 Tm (NTRK)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 187.3211 311.3298 Tm ( and )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 212.9895 311.3298 Tm (RET)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 234.9895 311.3298 Tm ( gene )Tj ET EMC /Span <>BDC BT 11 0 0 11 156.7703 299.3298 Tm (fusions\) and tumor )Tj ET EMC /Span <>BDC BT 11 0 0 11 156.7703 287.3298 Tm (mutational burden )Tj ET EMC /Span <>BDC BT 11 0 0 11 156.7703 275.3298 Tm (\(TMB\))Tj ET EMC /Span <>BDC BT 11 0 0 11 149.5703 263.3298 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 156.4775 263.3298 Tm (Consider clinical trial)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 131.5924 339.334 cm 0 0 m 10.545 0 l S Q q 1 0 0 1 147.6 339.334 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC endstream endobj 451 0 obj 19456 endobj %% Contents for page 39 %% Original object ID: 79 0 452 0 obj << /Length 453 0 R >> stream Q q BT /Xi37 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 453 0 obj 245 endobj %% Original object ID: 409 0 454 0 obj [ 2467 0 R 2468 0 R 2469 0 R 2470 0 R 2471 0 R 2472 0 R 2473 0 R ] endobj %% Contents for page 40 %% Original object ID: 80 0 455 0 obj << /Length 456 0 R >> stream q endstream endobj 456 0 obj 2 endobj %% Contents for page 40 %% Original object ID: 410 0 457 0 obj << /Length 458 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Hürthle Cell Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 727.3779 23.544 Tm [<48dc5254>72.8 (-)35 (9)]TJ ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 23.7374 518.0923 Tm [(TREA)73.9 (TMENT)17.6 ( )0.6 (OF)17.6 ( )0.6 (MET)74.2 (AST)74.2 (A)73.9 (TIC)17.3 ( )0.5 (DISEASE)17.4 ( )0.6 (NOT)17.6 ( )37.7 (AMENABLE)17.5 ( )0.6 (T)18 (O)17.6 ( )0.6 (RAI)17.6 ( )0.6 (THERAPY)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 9 0 0 9 438.4503 522.0923 Tm (hh)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.7612 246.9517 Tm (CNS metastases)Tj ET EMC 0.637 w /GS1 gs q 1 0 0 1 98.6541 114.4865 cm 0 0 m 197.787 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 6.8 0 0 6.8 23.044 157.9372 Tm (bb )Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 32.4969 155.3872 Tm [(Ethanol ablation, cryoablation, RF)53.4 (A, etc.)]TJ ET EMC /Span <>BDC BT 6.8 0 0 6.8 23.044 147.9372 Tm (dd )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 32.4969 145.3872 Tm (The decision of whether to use lenvatinib \(preferred\) or sorafenib should be individualized for ) Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 32.4969 135.3872 Tm (each patient based on likelihood of response and comorbidities.)Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 23.044 127.9372 Tm (ee )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 32.4969 125.3872 Tm (Kinase inhibitor therapy may not be appropriate for patients with stable or slowly progressive ) Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 32.4969 115.3872 Tm (indolent disease. )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 8.5 0 0 8.5 98.6541 115.3872 Tm [(See Principles of Kinase Inhibitor )16.4 (Therapy \(THYR-B\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 8.5 0 0 8.5 296.441 115.3872 Tm (.)Tj ET EMC /Span <>BDC BT -0.018 Tc 0.018 Tw 6.8 0 0 6.8 23.044 107.9372 Tm [(ff)-17.8 ( )]TJ /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 Tc 0 Tw 8.5 0 0 8.5 28.5889 105.3872 Tm [(Commercially available small-molecule kinase inhibitors \(such as a)-4.9 (xitinib, everolimus, )]TJ ET EMC /Span <>BDC BT 8.5 0 0 8.5 28.5889 95.3872 Tm (pazopanib, sunitinib, vandetanib, vemurafenib [)Tj ET EMC /Span <>BDC BT /TT2 1 Tf 8.5 0 0 8.5 206.263 95.3872 Tm [(BRAF)18.1 ( )]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 8.5 0 0 8.5 231.1404 95.3872 Tm (positive], dabrafenib [)Tj ET EMC /Span <>BDC BT /TT2 1 Tf 8.5 0 0 8.5 311.9402 95.3872 Tm [(BRAF)18.1 ( )]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 8.5 0 0 8.5 336.8177 95.3872 Tm (positive], )Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 28.5889 85.3872 Tm (or cabozantinib [all are category 2A]\) can be considered if clinical trials are not available or ) Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 28.5889 75.3872 Tm (appropriate.)Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 399.1925 157.9372 Tm (gg )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 408.6454 155.3872 Tm [(Cytotoxic chemotherapy has been shown to have minimal ef)15.4 (ficacy)74.1 (, although most studies were )]TJ ET EMC /Span <>BDC BT 8.5 0 0 8.5 408.6454 145.3872 Tm (small and underpowered.)Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 399.1925 137.9372 Tm (hh )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 408.6454 135.3872 Tm (RAI therapy is an option in some patients with bone metastases and RAI)Tj /Span<>> BDC (-)Tj EMC (sensitive disease.)Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 399.1925 127.9372 Tm (ii )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 404.1032 125.3872 Tm (Denosumab and intravenous bisphosphonates can be associated with severe hypocalcemia; ) Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 404.1032 115.3872 Tm (patients with hypoparathyroidism and vitamin D deficiency are at increased risk of hypocalcemia.) Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 399.1925 107.9372 Tm (jj )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 404.1032 105.3872 Tm [(After consultation with neurosurgery and radiation oncology; data on the ef) 14.7 (ficacy of lenvatinib or )]TJ ET EMC /Span <>BDC BT 8.5 0 0 8.5 404.1032 95.3872 Tm (sorafenib for patients with brain metastases have not been established.)Tj ET EMC /Span <>BDC BT 6.8 0 0 6.8 399.1925 87.9372 Tm (kk )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 8.5 0 0 8.5 407.8817 85.3872 Tm (TKI therapy should be used with caution in otherwise untreated CNS metastases due to ) Tj ET EMC /Span <>BDC BT 8.5 0 0 8.5 407.8817 75.3872 Tm (bleeding risk.)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS1 gs q 1 0 0 1 114.48 250.9559 cm 0 0 m 52.072 0 l S Q q 1 0 0 1 172.0141 250.9559 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 174.1012 169.0157 cm 0 0 m 0 163.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 298.7061 168.7862 cm 0 0 m 209.682 0 l S Q /Span <>BDC BT /GS0 gs /TT1 1 Tf 11 0 0 11 176.2612 323.9517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 183.1685 323.9517 Tm (For solitary CNS lesions, either neurosurgical resection or stereotactic radiosurgery is preferred) Tj ET EMC /Span <>BDC BT 11 0 0 11 686.8911 323.9517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 183.4612 312.9517 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 176.2612 301.9517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 183.1685 301.9517 Tm [(For multiple CNS lesions, consider radiotherapy)75.7 (, including image-guided radiotherapy)76.4 (, and/or resection in )]TJ ET EMC /Span <>BDC BT 11 0 0 11 183.4612 290.9517 Tm (select cases)Tj ET EMC /Span <>BDC BT 11 0 0 11 248.2957 290.9517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 183.4612 279.9517 Tm (and/or)Tj ET EMC /Span <>BDC BT 11 0 0 11 176.2612 268.9517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 183.1685 268.9517 Tm (Consider systemic therapy)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 179.8612 257.9517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 190.8612 257.9517 Tm (For progressive and/or symptomatic disease, consider lenvatinib \(preferred\) or sorafenib) Tj ET EMC /Span <>BDC BT 9 0 0 9 656.6586 261.9517 Tm (dd,jj,kk)Tj ET EMC /Span <>BDC BT 11 0 0 11 687.6664 257.9517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 190.6612 246.9517 Tm (and/or)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 179.8612 235.9517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 190.8612 235.9517 Tm (Larotrectinib or entrectinib for patients with )Tj ET EMC /Span <>BDC BT /TT3 1 Tf 11 0 0 11 422.4896 235.9517 Tm (NTRK)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 453.0404 235.9517 Tm ( gene fusion)Tj /Span<>> BDC (-)Tj EMC (positive advanced solid tumors )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 179.8612 224.9517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 190.8612 224.9517 Tm (Selpercatinib for patients with)Tj ET EMC /Span <>BDC BT /TT3 1 Tf 11 0 0 11 347.9388 224.9517 Tm ( RET)Tj ET EMC /Span <>BDC BT /TT1 1 Tf /Span<>> BDC 11 0 0 11 372.995 224.9517 Tm (-)Tj EMC (fusion positive tumors)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 179.8612 213.9517 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 190.8612 213.9517 Tm <003300480050004500550052004f004c005d005800500044004500030049005200550003005300440057004c00480051005700560003005a004c0057004b00030037003000250010002b0003000b0095001400130003005000580057001200300045000c0003005700580050005200550056>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 510.4037 213.9517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 190.6612 202.9517 Tm (and/or)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 179.8612 191.9517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 190.8612 191.9517 Tm (Other therapies are available and can be considered for progressive and/or symptomatic disease if clinical ) Tj ET EMC /Span <>BDC BT 11 0 0 11 190.6612 180.9517 Tm (trials or other systemic therapies are not available or appropriate.)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 9 0 0 9 533.6163 184.9517 Tm <00480048000f1087000f004a004a000f004d004d>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 176.2612 169.9517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 183.1684 169.9517 Tm (Best supportive care \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 298.706 169.9517 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 321.3344 169.9517 Tm (NCCN Guidelines for Palliative Care)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 508.3882 169.9517 Tm (\))Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS1 gs q 1 0 0 1 124.4212 428.5262 cm 0 0 m 42.131 0 l S Q q 1 0 0 1 172.0142 428.5262 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M /GS0 gs q 1 0 0 1 174.1012 346.586 cm 0 0 m 0 163.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 654.731 434.3565 cm 0 0 m 47.051 0 l S Q q 1 0 0 1 298.7061 346.3565 cm 0 0 m 209.682 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 176.2612 501.522 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 183.1684 501.522 Tm (Consider surgical palliation and/or EBRT/SBRT/other local therapies)Tj ET EMC /Span <>BDC BT 9 0 0 9 540.7329 505.522 Tm (bb)Tj ET EMC /Span <>BDC BT 11 0 0 11 551.728 501.522 Tm ( when available if symptomatic, or )Tj ET EMC /Span <>BDC BT 11 0 0 11 183.4612 490.522 Tm (asymptomatic in weight-bearing sites. Embolization prior to surgical resection of bone metastases should be ) Tj ET EMC /Span <>BDC BT 11 0 0 11 183.4612 479.522 Tm (considered to reduce the risk of hemorrhage.)Tj ET EMC /Span <>BDC BT 11 0 0 11 176.2612 468.522 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 183.1685 468.522 Tm (Consider embolization or other interventional procedures as alternatives to surgical resection/EBRT/IMRT in ) Tj ET EMC /Span <>BDC BT 11 0 0 11 183.4612 457.522 Tm (select cases.)Tj ET EMC /Span <>BDC BT 11 0 0 11 176.2612 446.522 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 183.1685 446.522 Tm (Consider intravenous bisphosphonate or denosumab.)Tj ET EMC /Span <>BDC BT 9 0 0 9 466.1445 450.522 Tm (ii)Tj ET EMC /Span <>BDC BT 11 0 0 11 176.2612 435.522 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 183.1685 435.522 Tm (Disease monitoring may be appropriate in asymptomatic patients with indolent disease.) Tj ET EMC /Span <>BDC BT 9 0 0 9 642.2197 439.522 Tm (ee )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 654.731 435.522 Tm [(\(HÜRT)54.8 (-6\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 176.2612 424.522 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 183.1685 424.522 Tm (Consider systemic therapy)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 179.8612 413.522 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 190.8612 413.522 Tm (For progressive and/or symptomatic disease, consider lenvatinib \(preferred\) or sorafenib.) Tj ET EMC /Span <>BDC BT 9 0 0 9 659.7147 417.522 Tm (dd)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 179.8612 402.522 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 190.8612 402.522 Tm (Larotrectinib or entrectinib for patients with )Tj ET EMC /Span <>BDC BT /TT3 1 Tf 11 0 0 11 422.4896 402.522 Tm (NTRK)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 453.0404 402.522 Tm ( gene fusion)Tj /Span<>> BDC (-)Tj EMC (positive advanced solid tumors.)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 179.8612 391.522 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 190.8612 391.522 Tm (Selpercatinib for patients with )Tj ET EMC /Span <>BDC BT /TT3 1 Tf 11 0 0 11 350.995 391.522 Tm (RET)Tj ET EMC /Span <>BDC BT /TT1 1 Tf /Span<>> BDC 11 0 0 11 372.995 391.522 Tm (-)Tj EMC (fusion positive tumors)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 179.8612 380.522 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 190.8612 380.522 Tm <003300480050004500550052004f004c005d005800500044004500030049005200550003005300440057004c00480051005700560003005a004c0057004b00030037003000250010002b0003000b0095001400130003005000580057001200300045000c0003005700580050005200550056>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 179.8612 369.522 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 190.8612 369.522 Tm (Other therapies are available and can be considered for progressive and/or symptomatic disease if clinical ) Tj ET EMC /Span <>BDC BT 11 0 0 11 190.6612 358.522 Tm (trials or other systemic therapies are not available or appropriate.)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 9 0 0 9 533.6163 362.522 Tm <00480048000f1087000f004a004a>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 176.2612 347.522 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 183.1684 347.522 Tm (Best supportive care \()Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 298.706 347.522 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 321.3344 347.522 Tm (NCCN Guidelines for Palliative Care)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 508.3882 347.522 Tm (\))Tj ET EMC /Span <>BDC BT 11 0 0 11 23.7612 424.522 Tm (Bone metastases)Tj ET EMC endstream endobj 458 0 obj 17854 endobj %% Contents for page 40 %% Original object ID: 81 0 459 0 obj << /Length 460 0 R >> stream Q q BT /Xi38 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 460 0 obj 245 endobj %% Original object ID: 412 0 461 0 obj [ 2474 0 R 2475 0 R 2476 0 R 2477 0 R 2478 0 R 2479 0 R 2480 0 R 2481 0 R 2482 0 R 2483 0 R 2484 0 R 2485 0 R ] endobj %% Contents for page 41 %% Original object ID: 82 0 462 0 obj << /Length 463 0 R >> stream q endstream endobj 463 0 obj 2 endobj %% Contents for page 41 %% Original object ID: 413 0 464 0 obj << /Length 465 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Medullary Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 724.9559 23.544 Tm [(MEDU)17.6 (-)35.4 (1)]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.7374 514.3517 Tm (CLINICAL)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.7374 502.3517 Tm [(PRESENT)74.2 (A)73.9 (TION)]TJ ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 423.1901 514.3517 Tm [(PRIMAR)36.8 (Y)35.5 ( )0.6 (TREA)73.9 (TMENT)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 84.864 378.1781 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 369.2338 Tm (Medullary )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 357.2338 Tm (thyroid )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 345.2338 Tm (carcinoma )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 333.2338 Tm (on FNA)Tj ET EMC q 1 0 0 1 164.784 212.5602 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 11 0 0 11 23.544 203.6158 Tm (Medullary thyroid )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 191.6158 Tm (carcinoma diagnosed )Tj ET EMC /Span <>BDC BT -0.009 Tw 11 0 0 11 23.544 179.6158 Tm [(after )-0.7 (initial thyroid surgery)]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 23.544 159.3932 Tm (Germline mutation of )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 23.544 147.3932 Tm (RET )Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 48.6002 147.3932 Tm (proto-oncogene)Tj ET EMC /Span <>BDC BT 9 0 0 9 132.314 151.3932 Tm (a,b)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 8 0 0 8 23.544 133.3872 Tm (a)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 130.3872 Tm [(In view of the risks of thyroidectomy in very young childre)-1.2 (n, referral to a surgeon )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 119.3872 Tm (and team experienced in pediatric thyroid surgery is advised.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 111.3872 Tm (b)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 108.3872 Tm [(Eviden)-0.6 (ce of pheochromocyt)-0.6 (oma should be evaluated and)-1.9 ( addressed )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 97.3872 Tm [(appropriately before proceeding to the next step on the pathway)71.3 (.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.544 89.3872 Tm (c)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 86.3872 Tm [(Germline mutation should p)-0.9 (rompt specific mutation testing in subsequent family )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 75.3872 Tm (members and genetic counseling.)Tj ET EMC /Span <>BDC BT 8 0 0 8 400.592 133.3872 Tm (d)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 406.352 130.3872 Tm [(V)55.2 (ocal cord mobility may be examined in patients with abn)-1.7 (ormal voice, surgical )]TJ ET EMC /Span <>BDC BT 10 0 0 10 406.352 119.3872 Tm (history involving the recurrent laryngeal or vagus nerves, invasive disease, or ) Tj ET EMC /Span <>BDC BT 10 0 0 10 406.352 108.3872 Tm (bulky disease of the central neck. )Tj ET EMC /Span <>BDC BT 8 0 0 8 400.592 100.3872 Tm (e)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 406.352 97.3872 Tm [(Having)-0.8 ( distant metastases does not mean that surgery is contraindicated.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 400.592 89.3872 Tm (f)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 406.352 86.3872 Tm [(Imaging may be indicated b)-0.9 (ased on high burden of disea)-1.8 (se, calcitonin )]TJ ET EMC /Span <>BDC BT 10 0 0 10 718.2221 86.3872 Tm ( )Tj ET EMC /Span <>BDC BT 10 0 0 10 406.352 75.3872 Tm [(>400 pg/mL, or elevated CEA)54.2 ( levels.)]TJ ET EMC /Artifact <>BDC 4 M q 1 0 0 1 86.28 355.238 cm 0 0 m 7.649 0 l S Q q 1 0 0 1 99.3909 355.238 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 101.52 230.2978 cm 0 0 m 0 249.88 l S Q q 1 0 0 1 334.0258 480.1781 cm 0 0 m 0 -249.88 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 103.68 471.2338 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 110.5872 471.2338 Tm (Basal serum calcitonin level)Tj ET EMC /Span <>BDC BT 11 0 0 11 103.68 459.2338 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 110.5872 459.2338 Tm (CEA)Tj ET EMC /Span <>BDC BT 11 0 0 11 103.68 447.2338 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 110.5872 447.2338 Tm (Pheochromocytoma screening)Tj ET EMC /Span <>BDC BT 9 0 0 9 271.3548 451.2338 Tm (b)Tj ET EMC /Span <>BDC BT 11 0 0 11 103.68 435.2338 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 110.5872 435.2338 Tm (Serum calcium)Tj ET EMC /Span <>BDC BT 11 0 0 11 103.68 423.2338 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 110.5872 423.2338 Tm (Consider genetic counseling )Tj ET EMC /Span <>BDC BT 11 0 0 11 103.68 411.2338 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 110.5872 411.2338 Tm (Screen for germline )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 216.9564 411.2338 Tm (RET)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 238.9564 411.2338 Tm ( proto-oncogene )Tj ET EMC /Span <>BDC BT 11 0 0 11 110.88 399.2338 Tm (mutations)Tj ET EMC /Span <>BDC BT 9 0 0 9 163.4361 403.2338 Tm (c)Tj ET EMC /Span <>BDC BT 11 0 0 11 168.4415 399.2338 Tm [( \(exons 10, 1)55.3 (1, 13\22616\))]TJ ET EMC /Span <>BDC BT 11 0 0 11 103.68 387.2338 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 110.5872 387.2338 Tm (Thyroid and neck ultrasound \(including )Tj ET EMC /Span <>BDC BT 11 0 0 11 110.88 375.2338 Tm (central and lateral compartments\), if not )Tj ET EMC /Span <>BDC BT 11 0 0 11 110.88 363.2338 Tm (previously done)Tj ET EMC /Span <>BDC BT 11 0 0 11 103.68 351.2338 Tm <9520>Tj ET EMC /Span <>BDC BT -0.011 Tw 11 0 0 11 110.5872 351.2338 Tm (Consider evaluation of vocal cord mobility )Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 110.88 339.2338 Tm [(\(ultrasound, mirror indirect laryngoscopy)75.3 (, )]TJ ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 110.88 327.2338 Tm <00520055000300bf004500480055005200530057004c00460003004f00440055005c0051004a00520056004600520053005c000c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 253.2892 331.2338 Tm (d)Tj ET EMC /Span <>BDC BT 11 0 0 11 103.68 315.2338 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 110.5872 315.2338 Tm (Additional cross)Tj /Span<>> BDC (-)Tj EMC (sectional imaging as )Tj ET EMC /Span <>BDC BT 11 0 0 11 110.88 303.2338 Tm (indicated:)Tj ET EMC /Span <>BDC BT 9 0 0 9 162.8292 307.2338 Tm (f)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 107.28 291.2338 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 118.28 291.2338 Tm (Consider contrast-enhanced CT of neck/)Tj ET EMC /Span <>BDC BT 11 0 0 11 118.08 279.2338 Tm (chest and liver MRI or 3-phase CT of )Tj ET EMC /Span <>BDC BT 11 0 0 11 118.08 267.2338 Tm (liver)Tj ET EMC /Span <>BDC BT 9 0 0 9 140.7084 271.2338 Tm (e)Tj ET EMC /Span <>BDC BT 9 0 0 9 145.7138 271.2338 Tm (,f)Tj ET EMC 0.945 w q 1 0 0 1 145.7138 274.2338 cm 0 0 m 5.498 0 l S Q /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 107.28 255.2338 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 118.28 255.2338 Tm [(Consider Ga-68 DOT)74.4 (A)74.1 (T)74.4 (A)74 (TE )]TJ ET EMC /Span <>BDC BT 11 0 0 11 262.3113 255.2338 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 118.08 243.2338 Tm [(PET/CT)111.2 (; if not available consider bone )]TJ ET EMC /Span <>BDC BT 11 0 0 11 118.08 231.2338 Tm (scan and/or skeletal MRI)Tj ET EMC /Artifact <>BDC 1 w 4 M q 1 0 0 1 169.2 195.62 cm 0 0 m 442.378 0 l S Q q 1 0 0 1 617.04 195.62 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 161.28 157.3973 cm 0 0 m 450.298 0 l S Q q 1 0 0 1 617.04 157.3973 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 407.28 420.7244 cm 0 0 m 8.318 0 l S Q q 1 0 0 1 421.06 420.7244 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 420.8367 337.7842 cm 0 0 m 0 165.88 l S Q /Span <>BDC BT 11 0 0 11 422.9967 494.7202 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 429.904 494.7202 Tm [(T)74.4 (otal thyroidectomy with bilateral central neck )]TJ ET EMC /Span <>BDC BT 11 0 0 11 430.1967 482.7202 Tm (dissection \(level VI\))Tj ET EMC /Span <>BDC BT 11 0 0 11 422.9967 470.7202 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 429.904 470.7202 Tm <0037004b0048005500440053004800580057004c00460003004c00530056004c004f00440057004800550044004f00030052005500030045004c004f00440057004800550044004f0003005000520047004c00bf004800470003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 430.1967 458.7202 Tm (neck dissection for clinically or radiologically )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 430.1967 446.7202 Tm <004c0047004800510057004c00bf00440045004f004800030047004c005600480044005600480003000b004f004800590048004f00560003002c002c00b10039000c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 422.9967 434.7202 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 429.904 434.7202 Tm <0026005200510056004c00470048005500030053005500520053004b005c004f004400460057004c00460003004c00530056004c004f00440057004800550044004f0003005000520047004c00bf004800470003005100480046004e0003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 430.1967 422.7202 Tm (dissection for high-volume or gross disease in )Tj ET EMC /Span <>BDC BT 11 0 0 11 430.1967 410.7202 Tm (the adjacent central neck)Tj ET EMC /Span <>BDC BT 11 0 0 11 422.9967 398.7202 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 429.904 398.7202 Tm (Consider therapeutic EBRT/IMRT for grossly )Tj ET EMC /Span <>BDC BT 11 0 0 11 430.1967 386.7202 Tm (incomplete tumor resection when additional )Tj ET EMC /Span <>BDC BT -0.001 Tw 11 0 0 11 430.1967 374.7202 Tm [(attempts )-0.7 (at surgical rese)-0.6 (ction have been ruled out)]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 422.9967 362.7202 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 429.904 362.7202 Tm (Adjuvant EBRT/IMRT is rarely recommended )Tj ET EMC /Span <>BDC BT 11 0 0 11 422.9967 350.7202 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 429.904 350.7202 Tm (Postoperative administration of levothyroxine to )Tj ET EMC /Span <>BDC BT 11 0 0 11 430.1967 338.7202 Tm (normalize TSH)Tj ET EMC q 1 0 0 1 346.6631 244.9619 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 404.8699 314.8422 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 348.8231 305.8979 Tm <001f0014001100130003004600500003004c00510003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 348.8231 293.8979 Tm (diameter )Tj ET EMC /Span <>BDC BT 11 0 0 11 348.8231 281.8979 Tm (and )Tj ET EMC /Span <>BDC BT 11 0 0 11 348.8231 269.8979 Tm (unilateral )Tj ET EMC /Span <>BDC BT 11 0 0 11 348.8231 257.8979 Tm (thyroid )Tj ET EMC /Span <>BDC BT 11 0 0 11 348.8231 245.8979 Tm (disease)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 406.6695 279.9022 cm 0 0 m 8.928 0 l S Q q 1 0 0 1 421.06 279.9022 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 422.9967 281.8979 Tm [(T)74.4 (otal thyroidectomy and consider )]TJ ET EMC /Span <>BDC BT 11 0 0 11 422.9967 269.8979 Tm (neck dissection \(level VI\))Tj ET EMC /Artifact <>BDC q 1 0 0 1 617.04 279.9022 cm 0 0 m 70.498 0 l S Q q 1 0 0 1 693 279.9022 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 698.48 359.9993 cm 0 0 m 49.495 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 698.48 409.1648 Tm (See)Tj ET EMC /Span <>BDC BT 11 0 0 11 718.0522 409.1648 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 698.48 397.1648 Tm (Management)Tj ET EMC /Span <>BDC BT 11 0 0 11 765.7153 397.1648 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 698.48 385.1648 Tm (2\2263 Months)Tj ET EMC /Span <>BDC BT 11 0 0 11 758.9907 385.1648 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 698.48 373.1648 Tm (Postoperative )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 698.48 361.1648 Tm (\(MEDU-5\))Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 344.16 391.7842 cm 0 0 m 0 57.88 l S Q q 1 0 0 1 404.52 449.6645 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT 0 0 0 scn /C2_0 1 Tf 11 0 0 11 346.32 440.7202 Tm <00950014001100130003004600500003004c00510003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 346.32 428.7202 Tm (diameter )Tj ET EMC /Span <>BDC BT -0.018 Tw 11 0 0 11 346.32 416.7202 Tm (or bilateral )Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 346.32 404.7202 Tm (thyroid )Tj ET EMC /Span <>BDC BT 11 0 0 11 346.32 392.7202 Tm (disease)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 696.1281 506.44 cm 0 0 m 0 -234.542 l S Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 622.44 196.4503 cm 0 0 m 142.56 0 l S Q q 1 0 0 1 622.44 184.4503 cm 0 0 m 119.786 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 622.44 197.6159 Tm [(See )37 (Additional W)19.2 (orkup and )]TJ ET EMC /Span <>BDC BT 11 0 0 11 622.44 185.6159 Tm (Management \(MEDU-2\))Tj ET EMC q 1 0 0 1 722.6553 146.2276 cm 0 0 m 49.495 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 623 159.3932 Tm [(See )37 (Additional W)19.2 (orkup and )]TJ ET EMC /Span <>BDC BT 11 0 0 11 623 147.3932 Tm [(Primary T)54.9 (reatment )]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 722.6553 147.3932 Tm (\(MEDU-3\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 0.035 Tc -0.017 Tw 11 0 0 11 119.5534 514.3517 Tm [(DIAGNOSTIC)17.2 ( )0.6 (PROCEDURES)]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M /GS1 gs q 1 0 0 1 350.9247 328.8436 cm 0 0 m -15.382 26.394 l -0.162 52.777 l S Q q 1 0 0 1 353.675 324.1243 cm 0 0 m -1.326 7.343 l -5.735 4.774 l h f Q q 1 0 0 1 353.4921 386.3516 cm 0 0 m -5.714 -4.799 l -1.294 -7.349 l h f Q EMC endstream endobj 465 0 obj 18762 endobj %% Contents for page 41 %% Original object ID: 83 0 466 0 obj << /Length 467 0 R >> stream Q q BT /Xi39 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 467 0 obj 245 endobj %% Original object ID: 415 0 468 0 obj [ 2486 0 R 2487 0 R 2488 0 R 2489 0 R 2490 0 R 2491 0 R 2492 0 R 2493 0 R 2494 0 R ] endobj %% Contents for page 42 %% Original object ID: 84 0 469 0 obj << /Length 470 0 R >> stream q endstream endobj 470 0 obj 2 endobj %% Contents for page 42 %% Original object ID: 416 0 471 0 obj << /Length 472 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Medullary Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 724.9559 23.544 Tm [(MEDU)17.6 (-)35.4 (2)]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.7374 514.3517 Tm (CLINICAL)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.7374 502.3517 Tm [(PRESENT)74.2 (A)73.9 (TION)]TJ ET EMC /Span <>BDC BT -0.084 Tw 11 0 0 11 147.0734 514.3517 Tm [(ADDITIONAL)35.7 ( WORKUP)]TJ ET EMC /Span <>BDC BT -0.035 Tw 11 0 0 11 633.5533 514.3517 Tm (MANAGEMENT)Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 117.3606 385.3743 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT 0 Tc -0.002 Tw 11 0 0 11 23.5446 376.43 Tm (Medullary thyroid )Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 23.5446 364.43 Tm (carcinoma )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.5446 352.43 Tm (diagnosed after )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.5446 340.43 Tm (initial thyroid )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.5446 328.43 Tm (surgery)Tj ET EMC /Span <>BDC BT 9 0 0 9 63.8976 332.43 Tm (g)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 119.5204 356.4341 cm 0 0 m 16.138 0 l S Q q 1 0 0 1 141.1204 356.4341 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 143.2802 315.494 cm 0 0 m 0 81.88 l S Q q 1 0 0 1 372.9602 397.3743 cm 0 0 m 0 -81.88 l S Q /Span <>BDC BT 11 0 0 11 145.4402 388.43 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 152.3474 388.43 Tm (Basal serum calcitonin level)Tj ET EMC /Span <>BDC BT 11 0 0 11 145.4402 376.43 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 152.3474 376.43 Tm (CEA)Tj ET EMC /Span <>BDC BT 11 0 0 11 145.4402 364.43 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 152.3474 364.43 Tm (Screen for germline)Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 255.6604 364.43 Tm ( RET )Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 283.7727 364.43 Tm (proto-oncogene )Tj ET EMC /Span <>BDC BT 11 0 0 11 152.6402 352.43 Tm (mutations)Tj ET EMC /Span <>BDC BT 9 0 0 9 205.1963 356.43 Tm (c,h)Tj ET EMC /Span <>BDC BT 11 0 0 11 218.1998 352.43 Tm [( \(exons 10, 1)55.2 (1, 13\22616\) with )]TJ ET EMC /Span <>BDC BT 11 0 0 11 152.6402 340.43 Tm (genetic counseling)Tj ET EMC /Span <>BDC BT 11 0 0 11 145.4402 328.43 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 152.3474 328.43 Tm (Central and lateral neck compartments )Tj ET EMC /Span <>BDC BT 11 0 0 11 152.6402 316.43 Tm (ultrasound, if not previously done)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 449.4889 317.7629 cm 0 0 m -73.302 38.671 l -0.777 77.322 l S Q q 1 0 0 1 454.32 315.2142 cm 0 0 m -5.011 5.529 l -7.393 1.015 l h f Q q 1 0 0 1 453.5321 397.6542 cm 0 0 m -7.388 -1.046 l -4.988 -5.55 l h f Q EMC /Span <>BDC BT 11 0 0 11 462.44 396.3099 Tm (Germline )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 513.1807 396.3099 Tm (RET )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 462.44 384.3099 Tm <00500058005700440057004c005200510003004c0047004800510057004c00bf00480047>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 462.44 315.6317 Tm (Germline )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 513.1807 315.6317 Tm (RET )Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 538.2369 315.6317 Tm (mutation )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 462.44 303.6317 Tm <0051005200570003004c0047004800510057004c00bf00480047>Tj ET EMC /Artifact <>BDC q 1 0 0 1 581.76 394.314 cm 0 0 m 40.618 0 l S Q q 1 0 0 1 627.84 394.314 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 584.979 313.6358 cm 0 0 m 37.399 0 l S Q q 1 0 0 1 627.84 313.6358 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 631.2 377.3739 cm 0 0 m 0 33.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 633.36 377.1443 cm 0 0 m 49.495 0 l S Q /Span <>BDC BT /GS0 gs /TT1 1 Tf -0.037 Tw 11 0 0 11 633.36 402.3099 Tm [(See Additional )-36.1 (W)18.3 (orkup )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 633.36 390.3099 Tm [(and Primary T)55.2 (reatment )]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 633.36 378.3099 Tm (\(MEDU-3\))Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 631.2 296.6957 cm 0 0 m 0 33.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 633.36 296.4662 cm 0 0 m 49.495 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 633.36 321.6317 Tm (See Management 2\2263 )Tj ET EMC /Span <>BDC BT 11 0 0 11 633.36 309.6317 Tm (Months Postoperative )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 633.36 297.6317 Tm (\(MEDU-5\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 8 0 0 8 23.7612 111.456 Tm (c)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 108.456 Tm [(Germline mutation should p)-0.9 (rompt specific mutation testing in subsequent family members and genetic counseling.) ]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 100.456 Tm (g)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm [(If initial thyroid surgery was less than a total thyroidectomy)74.2 (, additional surgical intervention \(eg, completion thyroidectomy ± central neck dissection\) may not be ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 86.456 Tm (necessary unless there is a positive germline )Tj ET EMC /Span <>BDC BT /TT3 1 Tf 10 0 0 10 231.2839 86.456 Tm (RET)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 10 0 0 10 251.2839 86.456 Tm ( mutation or radiographic evidence of disease \(ie, biopsy-proven residual neck disease\).) Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 78.456 Tm (h)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 75.456 Tm [(Prior to germline testing, all patients should be of)17.2 (fered genetic counseling either by their physician or a genetic counselor) 51.6 (.)]TJ ET EMC endstream endobj 472 0 obj 8804 endobj %% Contents for page 42 %% Original object ID: 85 0 473 0 obj << /Length 474 0 R >> stream Q q BT /Xi40 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 474 0 obj 245 endobj %% Original object ID: 418 0 475 0 obj [ 2495 0 R 2496 0 R 2497 0 R 2498 0 R 2499 0 R 2500 0 R 2501 0 R 2502 0 R 2503 0 R 2504 0 R 2505 0 R ] endobj %% Contents for page 43 %% Original object ID: 86 0 476 0 obj << /Length 477 0 R >> stream q endstream endobj 477 0 obj 2 endobj %% Contents for page 43 %% Original object ID: 419 0 478 0 obj << /Length 479 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Medullary Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 724.9559 23.544 Tm [(MEDU)17.6 (-)35.4 (3)]TJ ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 23.7374 514.3517 Tm [(CLINICAL)35.6 ( )0.6 (PRESENT)74.2 (A)73.9 (TION)]TJ ET EMC /Span <>BDC BT -0.061 Tw 11 0 0 11 280.1934 514.3517 Tm [(ADDITIONAL)35.7 ( WORKUP)]TJ ET EMC /Span <>BDC BT -0.068 Tw 11 0 0 11 428.6036 514.3517 Tm [(PRIMAR)36.8 (Y)35.5 ( )0.5 (TREA)73.9 (TMENT)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 101.551 374.7002 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 365.7559 Tm (Germline )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 353.7559 Tm (mutation of )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 23.544 341.7559 Tm (RET )Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 48.6002 341.7559 Tm (proto)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 23.544 329.7559 Tm (oncogene)Tj ET EMC /Span <>BDC BT 9 0 0 9 75.4932 333.7559 Tm (a,c)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 113.798 310.5809 cm 0 0 m -11.499 41.179 l -0.117 82.354 l S Q q 1 0 0 1 115.2671 305.32 cm 0 0 m 0.572 7.44 l -4.344 6.068 l h f Q q 1 0 0 1 115.1364 398.2 cm 0 0 m -4.328 -6.079 l 0.591 -7.439 l h f Q EMC 10 M q 1 0 0 1 108.4 405.4115 cm 0 0 m 0 33.88 l S Q q 1 0 0 1 212.0057 439.2918 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 11 0 0 11 110.56 430.3475 Tm (Multiple endocrine )Tj ET EMC /Span <>BDC BT -0.031 Tw 11 0 0 11 110.56 418.3475 Tm [(neoplasia )0.5 (\(MEN2B\))]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 110.56 406.3475 Tm (\()Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 114.2231 406.3475 Tm (RET )Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 139.2792 406.3475 Tm (mutations\))Tj ET EMC /Span <>BDC BT 9 0 0 9 195.4985 410.3475 Tm (i)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 216.054 422.3517 cm 0 0 m 56.938 0 l S Q q 1 0 0 1 278.454 422.3517 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 108.4 265.6798 cm 0 0 m 0 33.88 l S Q q 1 0 0 1 258.16 299.5602 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 11 0 0 11 110.56 290.6158 Tm (MEN2A/Familial medullary )Tj ET EMC /Span <>BDC BT 11 0 0 11 110.56 278.6158 Tm (thyroid carcinoma \(FMTC\) )Tj ET EMC /Span <>BDC BT 11 0 0 11 110.56 266.6158 Tm (\()Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 114.2231 266.6158 Tm (RET )Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 139.2792 266.6158 Tm (mutations\))Tj ET EMC /Span <>BDC BT 9 0 0 9 195.4985 270.6158 Tm (i)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 261.774 282.6199 cm 0 0 m 11.218 0 l S Q q 1 0 0 1 278.454 282.6199 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 279.4422 363.4115 cm 0 0 m 0 117.88 l S Q q 1 0 0 1 406.9622 481.2918 cm 0 0 m 0 -117.88 l S Q /Span <>BDC BT 11 0 0 11 281.6022 472.3475 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 288.5095 472.3475 Tm (Basal serum )Tj ET EMC /Span <>BDC BT 11 0 0 11 288.8022 460.3475 Tm (calcitonin level)Tj ET EMC /Span <>BDC BT 9 0 0 9 367.666 464.3475 Tm (j)Tj ET EMC /Span <>BDC BT 11 0 0 11 281.6022 448.3475 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 288.5095 448.3475 Tm (CEA)Tj ET EMC /Span <>BDC BT 11 0 0 11 281.6022 436.3475 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 288.5095 436.3475 Tm (Pheochromocytoma )Tj ET EMC /Span <>BDC BT 11 0 0 11 288.8022 424.3475 Tm (screening)Tj ET EMC /Span <>BDC BT 9 0 0 9 340.7676 428.3475 Tm (b,k)Tj ET EMC /Span <>BDC BT 11 0 0 11 281.6022 412.3475 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 288.5095 412.3475 Tm (Central and lateral )Tj ET EMC /Span <>BDC BT 11 0 0 11 288.8022 400.3475 Tm (neck compartments )Tj ET EMC /Span <>BDC BT 11 0 0 11 288.8022 388.3475 Tm (ultrasound,)Tj ET EMC /Span <>BDC BT 9 0 0 9 348.6899 392.3475 Tm (l)Tj ET EMC /Span <>BDC BT 11 0 0 11 351.1904 388.3475 Tm ( if not )Tj ET EMC /Span <>BDC BT 11 0 0 11 288.8022 376.3475 Tm (previously done)Tj ET EMC /Span <>BDC BT 11 0 0 11 281.6022 364.3475 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 288.5095 364.3475 Tm (Neck CT with contrast)Tj ET EMC q 1 0 0 1 279.4422 241.6799 cm 0 0 m 0 81.88 l S Q q 1 0 0 1 524.506 323.5602 cm 0 0 m 0 -81.88 l S Q /Span <>BDC BT 11 0 0 11 281.6022 314.6159 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 288.5095 314.6159 Tm (Basal serum calcitonin level)Tj ET EMC /Span <>BDC BT 9 0 0 9 435.8547 318.6159 Tm (j)Tj ET EMC /Span <>BDC BT 11 0 0 11 281.6022 302.6159 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 288.5095 302.6159 Tm (CEA)Tj ET EMC /Span <>BDC BT 11 0 0 11 281.6022 290.6159 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 288.5095 290.6159 Tm (Pheochromocytoma screening)Tj ET EMC /Span <>BDC BT 9 0 0 9 449.277 294.6159 Tm (b,k)Tj ET EMC /Span <>BDC BT 11 0 0 11 281.6022 278.6159 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 288.5095 278.6159 Tm (Serum calcium + parathyroid hormone \(PTH\))Tj ET EMC /Span <>BDC BT 11 0 0 11 281.6022 266.6159 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 288.5095 266.6159 Tm (Central and lateral neck compartments )Tj ET EMC /Span <>BDC BT 11 0 0 11 288.8022 254.6159 Tm (ultrasound,)Tj ET EMC /Span <>BDC BT 9 0 0 9 348.6899 258.6159 Tm (l)Tj ET EMC /Span <>BDC BT 11 0 0 11 351.1904 254.6159 Tm ( if not previously done)Tj ET EMC /Span <>BDC BT 11 0 0 11 281.6022 242.6159 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 288.5095 242.6159 Tm (Neck CT with contrast)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 409.4804 422.3517 cm 0 0 m 8.938 0 l S Q q 1 0 0 1 423.8805 422.3517 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 426.3987 369.4115 cm 0 0 m 0 105.88 l S Q q 1 0 0 1 670.3235 475.2918 cm 0 0 m 0 -105.88 l S Q /Span <>BDC BT 11 0 0 11 428.5587 466.3475 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 435.4659 466.3475 Tm [<0037>74.4 <005200570044004f00030057004b005c00550052004c004700480046005700520050005c0003004700580055004c0051004a00030057004b0048000300bf0055005600570003005c0048004400550003005200490003>]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 435.7587 454.3475 Tm (life or at diagnosis)Tj ET EMC /Span <>BDC BT 9 0 0 9 532.9432 458.3475 Tm (a)Tj ET EMC /Span <>BDC BT 11 0 0 11 428.5587 442.3475 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 435.4659 442.3475 Tm (Therapeutic neck dissection as indicated; )Tj ET EMC /Span <>BDC BT 11 0 0 11 435.7587 430.3475 Tm (consider prophylactic bilateral central neck )Tj ET EMC /Span <>BDC BT 11 0 0 11 435.7587 418.3475 Tm (dissection \(level VI\))Tj ET EMC /Span <>BDC BT 11 0 0 11 428.5587 406.3475 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 435.4659 406.3475 Tm (Consider more extensive node dissection )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 435.7587 394.3475 Tm <000b004f004800590048004f00560003002c002c00b10039000c0003004c0049000300570058005000520055000b0056000c000300210013001100180003004600500003004c005100030047004c0044005000480057004800550003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 428.5587 382.3475 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 435.4659 382.3475 Tm (Postoperative administration of )Tj ET EMC /Span <>BDC BT 11 0 0 11 435.7587 370.3475 Tm (levothyroxine to normalize TSH)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 530.746 282.6199 cm 0 0 m 150.058 0 l S Q q 1 0 0 1 686.2659 282.6199 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 672.8417 422.3517 cm 0 0 m 8.058 0 l S Q q 1 0 0 1 686.3618 422.3517 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 688.8801 393.4115 cm 0 0 m 0 57.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 691.04 393.182 cm 0 0 m 49.495 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 691.04 442.3475 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 691.04 430.3475 Tm (Management )Tj ET EMC /Span <>BDC BT 11 0 0 11 691.04 418.3475 Tm (2\2263 Months )Tj ET EMC /Span <>BDC BT 11 0 0 11 691.04 406.3475 Tm (Postoperative )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 691.04 394.3475 Tm (\(MEDU-5\))Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 689.8801 265.6798 cm 0 0 m 0 33.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 692.04 289.4503 cm 0 0 m 65.735 0 l S Q q 1 0 0 1 692.04 277.4503 cm 0 0 m 55.628 0 l S Q q 1 0 0 1 692.04 265.4503 cm 0 0 m 49.495 0 l S Q /Span <>BDC BT 11 0 0 11 692.04 290.6158 Tm (See Primary )Tj ET EMC /Span <>BDC BT 11 0 0 11 692.04 278.6158 Tm [(T)55.3 (reatment )]TJ ET EMC /Span <>BDC BT 11 0 0 11 692.04 266.6158 Tm (\(MEDU-4\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 8 0 0 8 23.544 210.76 Tm (a)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 207.76 Tm [(In view of the risks of thyroidectomy in very young childre)-1.2 (n, referral to a surgeon and team experienced in pediatric thyroid surgery is advised.) ]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.544 199.76 Tm (b)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 196.76 Tm [(Eviden)-0.6 (ce of pheochromocyt)-0.6 (oma should be evaluated and)-1.9 ( treated appropriately before proceeding to the next step on the pathway) 71.3 (.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.544 188.76 Tm (c)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 185.76 Tm [(Germline mutation should p)-0.9 (rompt specific mutation testing in subsequent family members and genetic counseling.) ]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.544 177.76 Tm (i)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 174.76 Tm [(The timing of prophylactic th)-0.6 (yroidectomy generally depen)-2.1 (ds on the aggressiveness of the inherited )]TJ ET EMC /Span <>BDC BT /TT3 1 Tf 10 0 0 10 467.3314 174.76 Tm (RET )Tj ET EMC /Span <>BDC BT /TT0 1 Tf 10 0 0 10 490.1097 174.76 Tm [(mutation. Codon M918T)17 ( mutations are considered highest )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 163.76 Tm [(risk and codon 634 and )53.9 (A883F mutations are considered high risk, with MTC usually presenting at a younger age, whereas other RET) 13.6 ( mutations associated with )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 152.76 Tm [(MEN2A)54.9 ( or FMTC are generally moderate risk. Prophylactic thyroidectomy may be delayed in patients with less high) ]TJ /Span<>> BDC (-)Tj EMC (risk )Tj ET EMC /Span <>BDC BT /TT3 1 Tf 10 0 0 10 560.6273 152.76 Tm (RET )Tj ET EMC /Span <>BDC BT /TT0 1 Tf 10 0 0 10 583.4056 152.76 Tm (mutations that have later onset of MTC, )Tj ET EMC /Span <>BDC BT 10 0 0 10 29.304 141.76 Tm (provided the annual basal calcitonin measurement is normal, the annual ultrasound is unremarkable, there is no history of aggressive MTC in the family) Tj 66.849 0 Td (, and the family )Tj ET EMC /Span <>BDC BT 10 0 0 10 29.304 130.76 Tm [(is in agreement. \(Brandi ML, et al. J Clin Endocrinol Metab 2001;86\(12\):5658-5671 and ) 50.9 (American )17.6 (Thyroid )54.9 (Association Guidelines )16.5 (T)111 (ask Force. W)18.4 (ells SA, et al. )18.3 (Thyroid )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 119.76 Tm (2015;25\(6\):567-610.\))Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 111.76 Tm (j)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 108.76 Tm [(Normal calcitonin ranges ha)-0.9 (ve not been established for v)-1.1 (ery young children.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.544 100.76 Tm (k)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 97.76 Tm [(Screening for pheochromoc)-1 (ytoma \(MEN2A)54.7 ( and MEN2B\) and hyperparathyroidism \(MEN2A\) should be performed annually) 70.2 (. For some RET)18.4 ( mutations \(codons 768, )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 86.76 Tm (790, 804, or 891\), less frequent screening may be appropriate.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 78.76 Tm (l)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 75.76 Tm [(In addition to ultrasound, pa)-0.7 (rathyroid imaging may includ)-1.9 (e sestamibi scan with SPECT)17.5 ( or 4D)]TJ /Span<>> BDC (-)Tj EMC [(CT)17.9 ( depending on institutional practice/protocol.)]TJ ET EMC endstream endobj 479 0 obj 16876 endobj %% Contents for page 43 %% Original object ID: 87 0 480 0 obj << /Length 481 0 R >> stream Q q BT /Xi41 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 481 0 obj 245 endobj %% Original object ID: 421 0 482 0 obj [ 2506 0 R 2507 0 R 2508 0 R 2509 0 R 2510 0 R 2511 0 R 2512 0 R 2513 0 R 2514 0 R 2515 0 R 2516 0 R 2517 0 R 2518 0 R ] endobj %% Contents for page 44 %% Original object ID: 88 0 483 0 obj << /Length 484 0 R >> stream q endstream endobj 484 0 obj 2 endobj %% Contents for page 44 %% Original object ID: 422 0 485 0 obj << /Length 486 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Medullary Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 724.9559 23.544 Tm [(MEDU)17.6 (-)35.4 (4)]TJ ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 23.9134 514.3517 Tm [(CLINICAL)35.6 ( )0.6 (PRESENT)74.2 (A)73.9 (TION)]TJ ET EMC /Span <>BDC BT -0.1 Tw 11 0 0 11 318.7982 514.3517 Tm [(PRIMAR)36.8 (Y)35.5 ( )0.6 (TREA)73.9 (TMENT)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.7612 358.5159 Tm (MEN2A/FMTC)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.7612 346.5159 Tm (\(RET mutations\))Tj ET EMC /Span <>BDC BT 9 0 0 9 108.6997 350.5159 Tm (a,c,i)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 130.5526 356.5201 cm 0 0 m 7.385 0 l S Q q 1 0 0 1 143.4 356.5201 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 145.84 333.5799 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 199.84 379.4602 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 11 0 0 11 148 370.5159 Tm (Measure )Tj ET EMC /Span <>BDC BT 11 0 0 11 148 358.5159 Tm (serum)Tj ET EMC /Span <>BDC BT 11 0 0 11 148 346.5159 Tm (calcium )Tj ET EMC /Span <>BDC BT 11 0 0 11 148 334.5159 Tm (± PTH )Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 221.0513 299.7955 cm 0 0 m -18.406 56.724 l -0.187 113.444 l S Q q 1 0 0 1 222.7371 294.6 cm 0 0 m 0.263 7.458 l -4.591 5.882 l h f Q q 1 0 0 1 222.5345 418.44 cm 0 0 m -4.574 -5.896 l 0.285 -7.457 l h f Q EMC /Span <>BDC BT 11 0 0 11 183.48 439.039 Tm (No primary )Tj ET EMC /Span <>BDC BT 11 0 0 11 183.48 427.039 Tm (hyperparathyroidism)Tj ET EMC /Artifact <>BDC q 1 0 0 1 301.5712 437.0432 cm 0 0 m 9.138 0 l S Q q 1 0 0 1 316.1712 437.0432 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT 11 0 0 11 183.48 281.4 Tm (Primary )Tj ET EMC /Span <>BDC BT 11 0 0 11 183.48 269.4 Tm (hyperparathyroidism)Tj ET EMC /Artifact <>BDC q 1 0 0 1 301.5712 279.4041 cm 0 0 m 9.138 0 l S Q q 1 0 0 1 316.1712 279.4041 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 316.9824 378.1029 cm 0 0 m 0 117.88 l S Q q 1 0 0 1 675.1776 495.9832 cm 0 0 m 0 -117.88 l S Q /Span <>BDC BT 11 0 0 11 319.1424 487.0389 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 326.0496 487.0389 Tm [(T)74.4 (otal thyroidectomy by age 5)]TJ ET EMC /Span <>BDC BT 9 0 0 9 477.4339 491.0389 Tm (a,i )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 489.9407 487.0389 Tm <005200550003005a004b00480051000300500058005700440057004c005200510003004c0047004800510057004c00bf00480047>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 633.5477 491.0389 Tm (a)Tj ET EMC /Span <>BDC BT 11 0 0 11 638.553 487.0389 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 641.6092 487.0389 Tm ( )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 326.3424 475.0389 Tm <000b004c0049000300500058005700440057004c005200510003004c0047004800510057004c00bf0048004700030044005700030052004f00470048005500030044004a0048000c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 319.1424 463.0389 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 326.0496 463.0389 Tm (Therapeutic ipsilateral or bilateral central neck dissection )Tj ET EMC /Span <>BDC BT 11 0 0 11 629.8817 463.0389 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 326.3424 451.0389 Tm (\(level VI\) if elevated calcitonin)Tj ET EMC /Span <>BDC BT 9 0 0 9 482.84 455.0389 Tm (m)Tj ET EMC /Span <>BDC BT 11 0 0 11 490.8424 451.0389 Tm [( or CEA)37.1 ( test or ultrasound )]TJ ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 326.3424 439.0389 Tm <004c0047004800510057004c00bf0048004700030057004b005c00550052004c004700030052005500030051005200470044004f00030044004500510052005500500044004f004c0057005c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 319.1424 427.0389 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 326.0496 427.0389 Tm <0026005200510056004c00470048005500030053005500520053004b005c004f004400460057004c00460003004c00530056004c004f00440057004800550044004f0003005000520047004c00bf004800470003005100480046004e00030047004c00560056004800460057004c005200510003004c004900030057004b0048005500480003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 326.3424 415.0389 Tm (is high-volume or gross disease in the adjacent central neck)Tj ET EMC /Span <>BDC BT 11 0 0 11 319.1424 403.0389 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 326.0496 403.0389 Tm (Consider more extensive lymph node dissection \(levels II\226V\) if )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 326.3424 391.0389 Tm <00570058005000520055000b0056000c000300210014001100130003004600500003005200550003004600480051005700550044004f00030051005200470048000b0056000c0003005300520056004c0057004c00590048>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 319.1424 379.0389 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 326.0496 379.0389 Tm (Postoperative administration of levothyroxine to normalize TSH)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 677.3888 437.0432 cm 0 0 m 9.178 0 l S Q q 1 0 0 1 692.0288 437.0432 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 694.2401 408.103 cm 0 0 m 0 57.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 696.4 407.8734 cm 0 0 m 49.495 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 696.4 457.039 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 696.4 445.039 Tm (Management )Tj ET EMC /Span <>BDC BT 11 0 0 11 696.4 433.039 Tm (2\2263 Months )Tj ET EMC /Span <>BDC BT 11 0 0 11 696.4 421.039 Tm (Postoperative )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 696.4 409.039 Tm (\(MEDU-5\))Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 316.9824 238.464 cm 0 0 m 0 81.88 l S Q q 1 0 0 1 612.8176 320.3443 cm 0 0 m 0 -81.88 l S Q /Span <>BDC BT 0 0 0 scn 11 0 0 11 319.1424 311.4 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 326.0496 311.4 Tm [(See Primary T)54.8 (reatment as outlined above)]TJ ET EMC /Span <>BDC BT 11 0 0 11 319.1424 299.4 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 326.0496 299.4 Tm (During primary operative procedure and parathyroid )Tj ET EMC /Span <>BDC BT 11 0 0 11 326.3424 287.4 Tm (exploration:)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 322.7424 275.4 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 333.7424 275.4 Tm (If single adenoma, excise)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 322.7424 263.4 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 333.7424 263.4 Tm (If multiglandular disease, autotransplant or leave the )Tj ET EMC /Span <>BDC BT 11 0 0 11 333.5424 251.4 Tm (equivalent mass of one normal parathyroid gland)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 322.7424 239.4 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 333.7424 239.4 Tm (Consider cryopreservation of parathyroid tissue)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 619.2288 279.4041 cm 0 0 m 64.938 0 l S Q q 1 0 0 1 689.6288 279.4041 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 693.2401 250.464 cm 0 0 m 0 57.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 695.4 250.2345 cm 0 0 m 49.495 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 695.4 299.4 Tm (See )Tj ET EMC /Span <>BDC BT 11 0 0 11 695.4 287.4 Tm (Management )Tj ET EMC /Span <>BDC BT 11 0 0 11 695.4 275.4 Tm (2\2263 Months )Tj ET EMC /Span <>BDC BT 11 0 0 11 695.4 263.4 Tm (Postoperative )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 695.4 251.4 Tm (\(MEDU-5\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 8 0 0 8 23.7612 177.456 Tm (a)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 174.456 Tm [(In view of the risks of thyroidectomy in very young childre)-1.2 (n, referral to a surgeon and team experienced in pediatric thyroid surgery is advised.) ]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 166.456 Tm (c)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 163.456 Tm [(Germline mutation should p)-0.9 (rompt specific mutation testing in subsequent family members and genetic counseling.) ]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 155.456 Tm (i)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 152.456 Tm [(The timing of prophylactic th)-0.6 (yroidectomy generally depen)-2.1 (ds on the aggressiveness of the inherited )]TJ ET EMC /Span <>BDC BT /TT2 1 Tf 10 0 0 10 467.5486 152.456 Tm (RET )Tj ET EMC /Span <>BDC BT /TT0 1 Tf 10 0 0 10 490.3269 152.456 Tm [(mutation. Codon M918T)17 ( mutations are considered highest )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 141.456 Tm [(risk and codon 634 and )53.9 (A883F mutations are considered high risk, with MTC usually presenting at a younger age, whereas other RET) 13.6 ( mutations associated with )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 130.456 Tm [(MEN2A)54.9 ( or FMTC are generally moderate risk. Prophylactic thyroidectomy may be delayed in patients with less high) ]TJ /Span<>> BDC (-)Tj EMC (risk )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 10 0 0 10 560.8445 130.456 Tm (RET )Tj ET EMC /Span <>BDC BT /TT0 1 Tf 10 0 0 10 583.6228 130.456 Tm (mutations that have later onset of MTC, )Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 119.456 Tm (provided the annual basal calcitonin measurement is normal, the annual ultrasound is unremarkable, there is no history of aggressive MTC in the family) Tj 66.849 0 Td (, and the family )Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 108.456 Tm [(is in agreement. \(Brandi ML, et al. J Clin Endocrinol Metab 2001;86:5658-5671 and ) 51.2 (American )17.6 (Thyroid )54.9 (Association Guidelines )16.5 (T)111 (ask Force. W)18.4 (ells SA, et al. )18.3 (Thyroid )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm (2015;25:567-610.\))Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 89.456 Tm (m )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 32.6479 86.456 Tm (Prophylactic neck dissection may not be required if serum calcitonin is less than 40 ng/mL, because lymph node metastases are unlikely with minor calcitonin ) Tj ET EMC /Span <>BDC BT 10 0 0 10 32.6479 75.456 Tm (elevations in this setting. )Tj ET EMC endstream endobj 486 0 obj 13986 endobj %% Contents for page 44 %% Original object ID: 89 0 487 0 obj << /Length 488 0 R >> stream Q q BT /Xi42 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 488 0 obj 245 endobj %% Original object ID: 424 0 489 0 obj [ 2519 0 R 2520 0 R 2521 0 R 2522 0 R 2523 0 R 2524 0 R 2525 0 R 2526 0 R 2527 0 R ] endobj %% Contents for page 45 %% Original object ID: 90 0 490 0 obj << /Length 491 0 R >> stream q endstream endobj 491 0 obj 2 endobj %% Contents for page 45 %% Original object ID: 425 0 492 0 obj << /Length 493 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Medullary Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 724.934 23.544 Tm [(MEDU)17.2 (-)35 (5)]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.7374 514.3517 Tm [(MANAGEMENT)17.6 ( 2)34.8 <96>34.9 (3)34.8 ( )-17.4 (MONTHS)17.4 ( )]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.7374 502.3517 Tm [(POST)18.1 (OPERA)73.9 (TIVE)]TJ ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 406.0037 514.3517 Tm [(DISEASE)17.5 ( )0.6 (MONIT)18.1 (ORING)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 9 0 0 9 535.0281 518.3517 Tm (o)Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 87.1194 320.2812 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 11 0 0 11 23.544 311.3369 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 311.3369 Tm (Basal )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 299.3369 Tm (calcitonin)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 287.3369 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 287.3369 Tm (CEA)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 114.2863 247.6111 cm 0 0 m -26.613 55.73 l -0.273 111.451 l S Q q 1 0 0 1 116.64 242.6821 cm 0 0 m -0.719 7.427 l -5.324 5.228 l h f Q q 1 0 0 1 116.3479 364.0001 cm 0 0 m -5.304 -5.249 l -0.69 -7.43 l h f Q EMC 10 M q 1 0 0 1 108.72 370.7628 cm 0 0 m 0 69.88 l S Q q 1 0 0 1 171.36 440.6431 cm 0 0 m 0 -69.88 l S Q /Span <>BDC BT 11 0 0 11 110.88 431.6988 Tm (Detectable )Tj ET EMC /Span <>BDC BT 11 0 0 11 110.88 419.6988 Tm (basal )Tj ET EMC /Span <>BDC BT 11 0 0 11 110.88 407.6988 Tm (calcitonin )Tj ET EMC /Span <>BDC BT 11 0 0 11 110.88 395.6988 Tm (or )Tj ET EMC /Span <>BDC BT 11 0 0 11 110.88 383.6988 Tm (Elevated)Tj ET EMC /Span <>BDC BT 11 0 0 11 110.88 371.6988 Tm (CEA)Tj ET EMC q 1 0 0 1 107.72 154.2599 cm 0 0 m 0 81.88 l S Q q 1 0 0 1 184.88 236.1402 cm 0 0 m 0 -81.88 l S Q /Span <>BDC BT 11 0 0 11 109.88 227.1958 Tm (Basal )Tj ET EMC /Span <>BDC BT 11 0 0 11 109.88 215.1958 Tm (calcitonin )Tj ET EMC /Span <>BDC BT 11 0 0 11 109.88 203.1958 Tm (undetectable )Tj ET EMC /Span <>BDC BT 11 0 0 11 109.88 191.1958 Tm (and)Tj ET EMC /Span <>BDC BT 11 0 0 11 109.88 179.1958 Tm [(CEA)36.8 ( within )]TJ ET EMC /Span <>BDC BT 11 0 0 11 109.88 167.1958 Tm (reference )Tj ET EMC /Span <>BDC BT 11 0 0 11 109.88 155.1958 Tm (range)Tj ET EMC /Span <>BDC BT 9 0 0 9 139.8346 159.1958 Tm (n)Tj ET EMC q 1 0 0 1 187.44 340.7628 cm 0 0 m 0 129.88 l S Q q 1 0 0 1 298.4224 470.6431 cm 0 0 m 0 -129.88 l S Q /Span <>BDC BT 11 0 0 11 189.6 461.6988 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 196.5072 461.6988 Tm (Neck ultrasound)Tj ET EMC /Span <>BDC BT 11 0 0 11 189.6 449.6988 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 196.5072 449.6988 Tm <002c0049000300460044004f0046004c005700520051004c0051000300950014001800130003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 196.8 437.6988 Tm (pg/mL, CT with )Tj ET EMC /Span <>BDC BT 11 0 0 11 196.8 425.6988 Tm (contrast of neck, )Tj ET EMC /Span <>BDC BT 11 0 0 11 196.8 413.6988 Tm [(liver)55.1 (, and chest)]TJ ET EMC /Span <>BDC BT 11 0 0 11 189.6 401.6988 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 196.5072 401.6988 Tm (Consider bone )Tj ET EMC /Span <>BDC BT 11 0 0 11 196.8 389.6988 Tm (scan and MRI of )Tj ET EMC /Span <>BDC BT 11 0 0 11 196.8 377.6988 Tm (axial skeleton in )Tj ET EMC /Span <>BDC BT 11 0 0 11 196.8 365.6988 Tm (patients with very )Tj ET EMC /Span <>BDC BT 11 0 0 11 196.8 353.6988 Tm (elevated calcitonin )Tj ET EMC /Span <>BDC BT 11 0 0 11 196.8 341.6988 Tm (levels)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 172.08 405.7029 cm 0 0 m 9.075 0 l S Q q 1 0 0 1 186.6168 405.7029 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 184.1337 195.2 cm 0 0 m 16.324 0 l S Q q 1 0 0 1 205.92 195.2 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 310.1159 379.3367 cm 0 0 m -11.253 26.366 l -0.117 52.725 l S Q q 1 0 0 1 312.26 374.3129 cm 0 0 m -0.406 7.451 l -5.099 5.448 l h f Q q 1 0 0 1 312.1249 437.093 cm 0 0 m -5.08 -5.466 l -0.378 -7.453 l h f Q EMC /Span <>BDC BT 11 0 0 11 208.8 191.1958 Tm (Disease monitoring)Tj ET EMC /Artifact <>BDC q 1 0 0 1 315.36 195.2 cm 0 0 m 75.178 0 l S Q q 1 0 0 1 396 195.2 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 310.1 441.3399 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 382.3487 487.2202 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 11 0 0 11 312.26 478.2759 Tm (Imaging )Tj ET EMC /Span <>BDC BT 11 0 0 11 312.26 466.2759 Tm (positive or )Tj ET EMC /Span <>BDC BT 11 0 0 11 312.26 454.2759 Tm (symptomatic )Tj ET EMC /Span <>BDC BT 11 0 0 11 312.26 442.2759 Tm (disease)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 387.2896 464.2801 cm 0 0 m 274.888 0 l S Q q 1 0 0 1 667.64 464.2801 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 310.1 335.3884 cm 0 0 m 0 33.88 l S Q q 1 0 0 1 389.4496 369.2687 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 11 0 0 11 312.26 360.3244 Tm (Imaging )Tj ET EMC /Span <>BDC BT 11 0 0 11 312.26 348.3244 Tm (negative and )Tj ET EMC /Span <>BDC BT 11 0 0 11 312.26 336.3244 Tm (asymptomatic)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 390.7629 352.3286 cm 0 0 m 9.775 0 l S Q q 1 0 0 1 406 352.3286 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 405.9432 287.3884 cm 0 0 m 0 129.88 l S Q q 1 0 0 1 578.7042 417.2687 cm 0 0 m 0 -129.88 l S Q /Span <>BDC BT 11 0 0 11 408.1032 408.3244 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 415.0104 408.3244 Tm [(Serum calcitonin, CEA)37.5 ( every )]TJ ET EMC /Span <>BDC BT 11 0 0 11 415.3032 396.3244 Tm (6\22612 mo)Tj ET EMC /Span <>BDC BT 11 0 0 11 408.1032 384.3244 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 415.0104 384.3244 Tm (Additional studies or more )Tj ET EMC /Span <>BDC BT 11 0 0 11 415.3032 372.3244 Tm (frequent testing based on )Tj ET EMC /Span <>BDC BT 11 0 0 11 415.3032 360.3244 Tm [(calcitonin/CEA)37.5 ( doubling time )]TJ ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 411.7032 348.3244 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 422.7032 348.3244 Tm (FDG PET/CT or Ga-68 )Tj ET EMC /Span <>BDC BT 11 0 0 11 422.5032 336.3244 Tm [(DOT)74.4 (A)74 (T)74.4 (A)74.1 (TE or MRI with )]TJ ET EMC /Span <>BDC BT 11 0 0 11 422.5032 324.3244 Tm (contrast of the neck, chest, )Tj ET EMC /Span <>BDC BT 11 0 0 11 422.5032 312.3244 Tm (abdomen with liver protocol)Tj ET EMC /Span <>BDC BT 11 0 0 11 408.1032 300.3244 Tm <9520>Tj ET EMC /Span <>BDC BT -0.013 Tw 11 0 0 11 415.0104 300.3244 Tm [(No additiona)0.5 (l imaging required )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 415.3032 288.3244 Tm [(if calcitonin and CEA)38.1 ( stable)]TJ ET EMC q 1 0 0 1 405.9432 124.2599 cm 0 0 m 0 141.88 l S Q q 1 0 0 1 587.04 266.1402 cm 0 0 m 0 -141.88 l S Q /Span <>BDC BT 11 0 0 11 408.1032 257.1959 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 415.0104 257.1959 Tm (Annual serum calcitonin, CEA)Tj ET EMC /Span <>BDC BT 11 0 0 11 408.1032 245.1959 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 415.0104 245.1959 Tm (Consider central and lateral )Tj ET EMC /Span <>BDC BT 11 0 0 11 562.9465 245.1959 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 415.3032 233.1959 Tm (neck compartments ultrasound)Tj ET EMC /Span <>BDC BT 11 0 0 11 408.1032 221.1959 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 415.0104 221.1959 Tm (Additional studies or more )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 415.3032 209.1959 Tm <0049005500480054005800480051005700030057004800560057004c0051004a0003004c004900030056004c004a0051004c00bf0046004400510057004f005c0003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 415.3032 197.1959 Tm (rising calcitonin or CEA)Tj ET EMC /Span <>BDC BT 11 0 0 11 408.1032 185.1959 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 415.0104 185.1959 Tm (No additional imaging required )Tj ET EMC /Span <>BDC BT 11 0 0 11 415.3032 173.1959 Tm [(if calcitonin and CEA)38.1 ( stable)]TJ ET EMC /Span <>BDC BT 11 0 0 11 408.1032 161.1959 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 415.0104 161.1959 Tm (For MEN2B or MEN2A, annual )Tj ET EMC /Span <>BDC BT 11 0 0 11 415.3032 149.1959 Tm (biochemical screenings for )Tj ET EMC /Span <>BDC BT 11 0 0 11 415.3032 137.1959 Tm (pheochromocytoma and )Tj ET EMC /Span <>BDC BT 11 0 0 11 415.3032 125.1959 Tm (hyperparathyroidism \(MEN2A\))Tj ET EMC /Span <>BDC BT 9 0 0 9 573.6108 129.1959 Tm (p)Tj ET EMC /Span <>BDC BT 11 0 0 11 604.64 391.0522 Tm (Positive)Tj ET EMC /Span <>BDC BT 11 0 0 11 604.64 379.0522 Tm (result)Tj ET EMC /Span <>BDC BT 11 0 0 11 604.64 318.4453 Tm (Negative)Tj ET EMC /Span <>BDC BT 11 0 0 11 604.64 306.4453 Tm (result)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 600.3032 171.3371 cm 0 0 m -11.295 23.863 l -0.118 47.717 l S Q q 1 0 0 1 602.64 166.4 cm 0 0 m -0.693 7.43 l -5.306 5.247 l h f Q q 1 0 0 1 602.5026 224 cm 0 0 m -5.286 -5.267 l -0.664 -7.432 l h f Q EMC /Span <>BDC BT 11 0 0 11 604.64 238.1261 Tm (Positive)Tj ET EMC /Span <>BDC BT 11 0 0 11 604.64 226.1261 Tm (result)Tj ET EMC /Span <>BDC BT 11 0 0 11 604.64 158.7117 Tm (Negative)Tj ET EMC /Span <>BDC BT 11 0 0 11 604.64 146.7117 Tm (result)Tj ET EMC /Artifact <>BDC q 1 0 0 1 649.64 389.0565 cm 0 0 m 12.538 0 l S Q q 1 0 0 1 667.64 389.0565 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 655.82 316.4495 cm 0 0 m 6.358 0 l S Q q 1 0 0 1 667.64 316.4495 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 654.82 236.1302 cm 0 0 m 7.358 0 l S Q q 1 0 0 1 667.64 236.1302 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 652.82 156.7159 cm 0 0 m 9.358 0 l S Q q 1 0 0 1 667.64 156.7159 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 669.14 488.0842 cm 0 0 m 0 -109.364 l S Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 671.14 422.2324 cm 0 0 m 71.5 0 l S Q q 1 0 0 1 671.14 410.2324 cm 0 0 m 45.832 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 671.14 447.3979 Tm (See Recurrent or )Tj ET EMC /Span <>BDC BT 11 0 0 11 671.14 435.3979 Tm (Persistent Disease )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 671.14 423.3979 Tm (\()Tj ET EMC /Span <>BDC BT 11 0 0 11 674.8031 423.3979 Tm (MEDU-6)Tj ET EMC /Span <>BDC BT 11 0 0 11 716.9716 423.3979 Tm ( and )Tj ET EMC /Span <>BDC BT 11 0 0 11 671.14 411.3979 Tm (MEDU-7)Tj ET EMC /Span <>BDC BT 11 0 0 11 713.3085 411.3979 Tm (\))Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 668.98 275.5093 cm 0 0 m 0 81.88 l S Q /Span <>BDC BT 0 0 0 scn -0.003 Tw 11 0 0 11 671.14 348.4453 Tm (Continue disease )Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 671.14 336.4453 Tm (monitoring )Tj ET EMC /Span <>BDC BT 11 0 0 11 671.14 324.4453 Tm (or)Tj ET EMC /Span <>BDC BT -0.06 Tw 11 0 0 11 671.14 312.4453 Tm (Consider cervical )Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 671.14 300.4453 Tm (reoperation, if )Tj ET EMC /Span <>BDC BT 11 0 0 11 671.14 288.4453 Tm (primary surgery )Tj ET EMC /Span <>BDC BT 11 0 0 11 671.14 276.4453 Tm (incomplete )Tj ET EMC q 1 0 0 1 668.98 213.1901 cm 0 0 m 0 45.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 671.14 224.9606 cm 0 0 m 71.5 0 l S Q q 1 0 0 1 671.14 212.9606 cm 0 0 m 45.832 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 671.14 250.1261 Tm (See Recurrent or )Tj ET EMC /Span <>BDC BT 11 0 0 11 671.14 238.1261 Tm (Persistent Disease )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 671.14 226.1261 Tm (\()Tj ET EMC /Span <>BDC BT 11 0 0 11 674.8031 226.1261 Tm (MEDU-6)Tj ET EMC /Span <>BDC BT 11 0 0 11 716.9716 226.1261 Tm ( and )Tj ET EMC /Span <>BDC BT 11 0 0 11 671.14 214.1261 Tm (MEDU-7)Tj ET EMC /Span <>BDC BT 11 0 0 11 713.3085 214.1261 Tm (\))Tj ET EMC 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 668.98 139.7757 cm 0 0 m 0 33.88 l S Q /Span <>BDC BT 0 0 0 scn 11 0 0 11 671.14 164.7117 Tm (Continue )Tj ET EMC /Span <>BDC BT 11 0 0 11 671.14 152.7117 Tm (disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 671.14 140.7117 Tm (monitoring)Tj ET EMC 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 29.5212 85.3964 cm 0 0 m 171.733 0 l S Q q 1 0 0 1 154.5847 74.3964 cm 0 0 m 259.575 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 8 0 0 8 23.7612 100.456 Tm (n)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm [(The likelihood)-0.9 ( of significant residual disease with an unde)-2.2 (tectable basal calcitonin is very low)53 (.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 89.456 Tm (o)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 86.456 Tm [(See NCCN Guidelines for S)-0.8 (urvivorship)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 201.2546 86.456 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 78.456 Tm (p)Tj ET EMC /Span <>BDC BT /Span<>> BDC 8 0 0 8 28.2104 78.456 Tm ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 75.456 Tm (See page PHEO-1 from the )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 154.5847 75.456 Tm [(NCCN Guidelines for Neuroe)-2 (ndocrine and )54.1 (Adrenal )17.4 (T)37.3 (umors)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 414.1599 75.456 Tm (.)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 597.7374 323.9081 cm 0 0 m -17.828 28.42 l -0.188 56.828 l S Q q 1 0 0 1 600.64 319.281 cm 0 0 m -1.565 7.296 l -5.888 4.584 l h f Q q 1 0 0 1 600.4309 385.376 cm 0 0 m -5.867 -4.611 l -1.531 -7.303 l h f Q EMC endstream endobj 493 0 obj 19020 endobj %% Contents for page 45 %% Original object ID: 91 0 494 0 obj << /Length 495 0 R >> stream Q q BT /Xi43 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 495 0 obj 245 endobj %% Original object ID: 427 0 496 0 obj [ 2528 0 R 2529 0 R 2530 0 R 2531 0 R 2532 0 R 2533 0 R ] endobj %% Contents for page 46 %% Original object ID: 92 0 497 0 obj << /Length 498 0 R >> stream q endstream endobj 498 0 obj 2 endobj %% Contents for page 46 %% Original object ID: 428 0 499 0 obj << /Length 500 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Medullary Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 724.934 23.544 Tm [(MEDU)17.2 (-)35 (6)]TJ ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 23.7374 514.28 Tm [(RECURRENT)17.6 ( )0.6 (OR)17.3 ( )0.5 (PERSISTENT)17.6 ( )0.6 (DISEASE)]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.7374 502.28 Tm [(LOCOREGIONAL)35.6 ( )0.6 (DISEASE)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 354 Tm (Locoregional)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 102.5984 358.0042 cm 0 0 m 122.339 0 l S Q q 1 0 0 1 230.4 358.0042 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 649.0001 335.064 cm 0 0 m 0 45.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.16 334.8345 cm 0 0 m 72.123 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 651.16 372 Tm (Recurrent or )Tj ET EMC /Span <>BDC BT 11 0 0 11 651.16 360 Tm (Persistent Disease;)Tj ET EMC /Span <>BDC BT 11 0 0 11 651.16 348 Tm (Distant Metastases)Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 651.16 336 Tm (\()Tj ET EMC /Span <>BDC BT 11 0 0 11 654.8231 336 Tm (See MEDU-7)Tj ET EMC /Span <>BDC BT 11 0 0 11 719.62 336 Tm (\))Tj ET EMC q 1 0 0 1 518.6765 96.3964 cm 0 0 m 246.074 0 l S Q q 1 0 0 1 29.5212 85.3964 cm 0 0 m 131.133 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 8 0 0 8 23.7612 144.456 Tm (q)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 141.456 Tm [(Increasing tumor markers, in)-0.6 ( the absence of structural dis)-0.9 (ease progression, are not an indication for treatment with systemic therapy) 71.8 (. )]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 133.456 Tm (r)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 130.456 Tm [(Only health care professiona)-0.9 (ls and pharmacies certified t)-1 (hrough the vandetanib Risk Evaluation and Mitigation Strategy \(REMS\) program, a restricted distribution ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 119.456 Tm (program, will be able to prescribe and dispense the drug.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 111.456 Tm (s)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 108.456 Tm [(Genomic testing including tu)-1.1 (mor mutational burden \(TMB)-1 (\) or )]TJ ET EMC /Span <>BDC BT /TT2 1 Tf 10 0 0 10 300.1951 108.456 Tm (RET)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 10 0 0 10 320.1951 108.456 Tm ( somatic genotyping in patients who are germline wild)Tj /Span<>> BDC (-)Tj EMC (type or germline unknown.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 100.456 Tm (t)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm [(Kinase)-0.6 ( inhibit)-0.8 (or therapy may not be appropriate for patien)-1.5 (ts with stable or slowly progressive indolent disease. )]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 518.6765 97.456 Tm [(See Principles of Kinase Inhibitor )16.4 (Therapy in )54.8 (Advanced )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 86.456 Tm (Thyroid Carcinoma \(THYR-B\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 160.654 86.456 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 78.456 Tm (u)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 75.456 Tm [(T)37.3 (reatment with systemic therapy is not recommended for)-0.9 ( increasing calcitonin/CEA)53.5 ( alone.)]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 541.3616 358.0042 cm 0 0 m 95.338 0 l S Q q 1 0 0 1 642.1616 358.0042 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Span <>BDC BT /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 266.9101 514.28 Tm [(TREA)73.9 (TMENT)]TJ ET EMC 10 M q 1 0 0 1 235.5358 287.064 cm 0 0 m 0 141.88 l S Q q 1 0 0 1 540.7223 428.9443 cm 0 0 m 0 -141.88 l S Q 0.75 w q 1 0 0 1 252.2958 358.8345 cm 0 0 m 104.543 0 l S Q q 1 0 0 1 252.2958 310.8345 cm 0 0 m 169.329 0 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 237.6958 420 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 244.603 420 Tm (Surgical resection is the preferred treatment modality )Tj ET EMC /Span <>BDC BT 11 0 0 11 237.6958 408 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 244.603 408 Tm (EBRT/IMRT can be considered for unresectable disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 244.8958 396 Tm [(or)55.2 (, less commonly)74.4 (, after surgical resection)]TJ ET EMC /Span <>BDC BT 11 0 0 11 237.6958 384 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 244.603 384 Tm (Consider systemic therapy)Tj ET EMC /Span <>BDC BT 9 0 0 9 385.2129 388 Tm (q)Tj ET EMC /Span <>BDC BT 11 0 0 11 390.7104 384 Tm ( for unresectable disease )Tj ET EMC /Span <>BDC BT -0.004 Tw 11 0 0 11 244.8958 372 Tm [(that )0.6 (is )0.6 (symptomatic )0.5 (or )0.6 (progressing )0.8 (by )0.6 (RECIST )0.7 (criteria)]TJ ET EMC /Span <>BDC BT 0 Tw 9 0 0 9 527.5671 376 Tm (t,u)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 241.2958 360 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 252.2958 360 Tm (Preferred Regimens)Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 261.1313 348 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 255.6958 348 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 264.1875 348 Tm [(V)55.2 (andetanib)]TJ ET EMC /Span <>BDC BT 9 0 0 9 322.8667 352 Tm (r)Tj ET EMC /Span <>BDC BT 11 0 0 11 326.3691 348 Tm ( \(category 1\))Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 261.1313 336 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 255.6958 336 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 264.1875 336 Tm (Cabozantinib \(category 1\))Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 261.1313 324 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 255.6958 324 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 264.1875 324 Tm (Selpercatinib \()Tj ET EMC /Span <>BDC BT /TT3 1 Tf 11 0 0 11 339.9843 324 Tm (RET)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 361.9843 324 Tm ( mutation)Tj /Span<>> BDC (-)Tj EMC (positive\))Tj ET EMC /Span <>BDC BT 9 0 0 9 460.372 328 Tm (s)Tj ET EMC /Span <>BDC BT 11 0 0 11 465.3774 324 Tm ( )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 241.2958 312 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 252.2958 312 Tm (Useful in Certain Circumstances)Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 261.1313 300 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 255.6958 300 Tm <00a1>Tj ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 264.1875 300 Tm <003300480050004500550052004f004c005d00580050004400450003000b0037003000250010002b0003003e00950014001300030050005800570012003000450040000c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 462.7192 304 Tm (s)Tj ET EMC /Span <>BDC BT 11 0 0 11 237.6958 288 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 244.603 288 Tm (Disease monitoring)Tj ET EMC endstream endobj 500 0 obj 10406 endobj %% Contents for page 46 %% Original object ID: 93 0 501 0 obj << /Length 502 0 R >> stream Q q BT /Xi44 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 502 0 obj 245 endobj %% Original object ID: 430 0 503 0 obj [ 2534 0 R 2535 0 R 2536 0 R 2537 0 R 2538 0 R ] endobj %% Contents for page 47 %% Original object ID: 94 0 504 0 obj << /Length 505 0 R >> stream q endstream endobj 505 0 obj 2 endobj %% Contents for page 47 %% Original object ID: 431 0 506 0 obj << /Length 507 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma \226 Medullary Carcinoma)Tj ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 724.934 23.544 Tm [(MEDU)17.2 (-)35 (7)]TJ ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 23.7374 514.28 Tm [(RECURRENT)17.6 ( )0.6 (OR)17.3 ( )0.5 (PERSISTENT)17.6 ( )0.6 (DISEASE)]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.7374 502.28 Tm [(DIST)74.2 (ANT)17.6 ( )0.6 (MET)74.2 (AST)74.2 (ASES)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 441.5917 Tm (Asymptomatic)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 429.5917 Tm (disease)Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 143.2794 292.4101 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 11 0 0 11 24.544 283.4658 Tm (Symptomatic disease)Tj ET EMC /Span <>BDC BT 11 0 0 11 24.544 271.4658 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 24.544 259.4658 Tm (progression)Tj ET EMC /Span <>BDC BT 9 0 0 9 88.1109 263.4658 Tm (t)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 145.3323 275.47 cm 0 0 m 54.186 0 l S Q q 1 0 0 1 204.98 275.47 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 104.76 439.5959 cm 0 0 m 94.258 0 l S Q q 1 0 0 1 204.48 439.5959 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 209.9998 186.5298 cm 0 0 m 0 177.88 l S Q 0.75 w q 1 0 0 1 226.7598 342.3003 cm 0 0 m 104.543 0 l S Q q 1 0 0 1 226.7598 294.3003 cm 0 0 m 166.875 0 l S Q q 1 0 0 1 226.7598 258.3003 cm 0 0 m 169.329 0 l S Q /Span <>BDC BT 11 0 0 11 212.1598 355.4658 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 219.067 355.4658 Tm (Systemic therapy or clinical trial)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 215.7598 343.4658 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 226.7598 343.4658 Tm (Preferred Regimens)Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 235.5953 331.4658 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 230.1598 331.4658 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 238.6515 331.4658 Tm [(V)55.2 (andetanib)]TJ ET EMC /Span <>BDC BT 9 0 0 9 297.3307 335.4658 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 299.8312 331.4658 Tm (\(category 1\))Tj ET EMC /Span <>BDC BT 9 0 0 9 362.1842 335.4658 Tm (v)Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 235.5953 319.4658 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 230.1598 319.4658 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 238.6515 319.4658 Tm (Cabozantinib \(category 1\))Tj ET EMC /Span <>BDC BT 9 0 0 9 373.1115 323.4658 Tm (v)Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 235.5953 307.4658 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 230.1598 307.4658 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 238.6515 307.4658 Tm (Selpercatinib \()Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 314.4484 307.4658 Tm (RET)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 336.4484 307.4658 Tm ( mutation)Tj /Span<>> BDC (-)Tj EMC (positive\))Tj ET EMC /Span <>BDC BT 9 0 0 9 434.8361 311.4658 Tm (s)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 215.7598 295.4658 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 226.7598 295.4658 Tm (Other Recommended Regimens)Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 235.5953 283.4658 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 230.1598 283.4658 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 238.6515 283.4658 Tm (Consider other small-molecule kinase inhibitors)Tj ET EMC /Span <>BDC BT 9 0 0 9 489.879 287.4658 Tm (w)Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 235.5953 271.4658 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 230.1598 271.4658 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 238.6515 271.4658 Tm (Dacarbazine \(DTIC\)-based chemotherapy)Tj ET EMC /Span <>BDC BT 9 0 0 9 453.2052 275.4658 Tm (x)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 215.7598 259.4658 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 226.7598 259.4658 Tm (Useful in Certain Circumstances)Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 235.5953 247.4658 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 230.1598 247.4658 Tm <00a1>Tj ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 238.6515 247.4658 Tm <003300480050004500550052004f004c005d00580050004400450003000b0037003000250010002b0003003e00950014001300030050005800570012003000450040000c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 437.1832 251.4658 Tm (s)Tj ET EMC /Span <>BDC BT 11 0 0 11 212.1598 235.4658 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 219.067 235.4658 Tm (EBRT/IMRT for local symptoms)Tj ET EMC /Span <>BDC BT 11 0 0 11 212.1598 223.4658 Tm <9520>Tj ET EMC /Span <>BDC BT -0.003 Tw 11 0 0 11 219.067 223.4658 Tm [(Consider intravenous bisphosphonate )0.6 (or denosumab)]TJ ET EMC /Span <>BDC BT 0 Tw 9 0 0 9 498.8725 227.4658 Tm (y )Tj ET EMC /Span <>BDC BT -0.003 Tw 11 0 0 11 506.3549 223.4658 Tm (therapy for bone metastases )Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 212.1598 211.4658 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 219.067 211.4658 Tm [(Consider palliative resection, ablation \(eg, RF)56.8 (A, embolization,)]TJ ET EMC /Span <>BDC BT 11 0 0 11 541.1823 211.4658 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 219.3598 199.4658 Tm (other regional therapy\), or other regional treatment)Tj ET EMC /Span <>BDC BT 11 0 0 11 212.1598 187.4658 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 219.067 187.4658 Tm (Best supportive care)Tj ET EMC /Span <>BDC BT 11 0 0 11 658.256 441.5917 Tm (Progressive disease,)Tj ET EMC /Span <>BDC BT 11 0 0 11 658.256 429.5917 Tm (see pathway below)Tj ET EMC /Artifact <>BDC 1 w 4 M q 1 0 0 1 610.56 439.5959 cm 0 0 m 35.437 0 l S Q q 1 0 0 1 651.459 439.5959 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.675 w 10 M /GS1 gs q 1 0 0 1 147.7978 94.2336 cm 0 0 m 221.467 0 l S Q q 1 0 0 1 28.728 84.3336 cm 0 0 m 118.02 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 7.2 0 0 7.2 23.544 167.1872 Tm (q)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 9 0 0 9 28.728 164.4872 Tm [(Increasing tumor markers, in the absence of structural disease )-0.9 (progression, are not an )]TJ ET EMC /Span <>BDC BT 9 0 0 9 28.728 154.5872 Tm [(indication for treatment with systemic therapy)72.9 (. )]TJ ET EMC /Span <>BDC BT 7.2 0 0 7.2 23.544 147.3872 Tm (r)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 9 0 0 9 28.728 144.6872 Tm [(Only health care professionals )-1.1 (and pharmacies certified through)-1.9 ( the vandetanib REMS )]TJ ET EMC /Span <>BDC BT 9 0 0 9 28.728 134.7872 Tm (program, a restricted distribution program, will be able to prescribe and dispense the drug.) Tj ET EMC /Span <>BDC BT 7.2 0 0 7.2 23.544 127.5872 Tm (s)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 9 0 0 9 28.728 124.8872 Tm [(Genomic testing including tumo)-1.2 (r mutational burden \(TMB\) or )]TJ ET EMC /Span <>BDC BT /TT3 1 Tf 9 0 0 9 272.3345 124.8872 Tm (RET)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 9 0 0 9 290.3345 124.8872 Tm ( somatic genotyping in )Tj ET EMC /Span <>BDC BT 9 0 0 9 28.728 114.9872 Tm (patients who are germline wild)Tj /Span<>> BDC (-)Tj EMC (type or germline unknown.)Tj ET EMC /Span <>BDC BT 7.2 0 0 7.2 23.544 107.7872 Tm (t)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 9 0 0 9 28.728 105.0872 Tm [(Kinase)-0.6 ( inhibitor therapy may no)-1.2 (t be appropriate for patients with)-1.2 ( stable or slowly )]TJ ET EMC /Span <>BDC BT 9 0 0 9 28.728 95.1872 Tm (progressive indolent disease. )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 9 0 0 9 147.7979 95.1872 Tm [(See Principles of Kinase Inhibitor )16.4 (Therapy in )54.8 (Advanced )]TJ ET EMC /Span <>BDC BT 9 0 0 9 28.728 85.2872 Tm (Thyroid Carcinoma \(THYR-B\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 9 0 0 9 146.7476 85.2872 Tm (.)Tj ET EMC /Span <>BDC BT 7.2 0 0 7.2 23.544 78.0872 Tm (u)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 9 0 0 9 28.728 75.3872 Tm [(T)37.3 (reatment with systemic therapy is not recommended for increa)-1.1 (sing calcitonin/CEA)53.9 ( alone.)]TJ ET EMC /Span <>BDC BT 7.2 0 0 7.2 400.05 167.1872 Tm (v)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 9 0 0 9 405.234 164.4872 Tm [(Clinica)-1 (l benefit can be seen in b)-1 (oth sporadic and familial MTC.)]TJ ET EMC /Span <>BDC BT 7.2 0 0 7.2 400.05 157.2872 Tm (w)Tj ET EMC /Span <>BDC BT 7.2 0 0 7.2 405.2496 157.2872 Tm ( )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 9 0 0 9 407.25 154.5872 Tm [(While not FDA)54.9 ( approved for treatment of medullary thyroid cancer)53.4 (, other commercially )]TJ ET EMC /Span <>BDC BT 9 0 0 9 407.25 144.6872 Tm (available small-molecule kinase inhibitors \(such as sorafenib, sunitinib, lenvatinib, or ) Tj ET EMC /Span <>BDC BT 9 0 0 9 407.25 134.7872 Tm (pazopanib\) can be considered if clinical trials or preferred systemic therapy options are not ) Tj ET EMC /Span <>BDC BT 9 0 0 9 407.25 124.8872 Tm (available or appropriate, or if the patient progresses on preferred systemic therapy options) Tj ET EMC /Span <>BDC BT 7.2 0 0 7.2 400.05 117.6872 Tm (x)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 9 0 0 9 405.234 114.9872 Tm [(Doxoru)-0.6 (bicin/streptozocin altern)-1.2 (ating with fluorouracil/dacarbazin)-2.4 (e or fluorouracil/)]TJ ET EMC /Span <>BDC BT 9 0 0 9 405.234 105.0872 Tm (dacarbazine alternating with fluorouracil/streptozocin.)Tj ET EMC /Span <>BDC BT 7.2 0 0 7.2 400.05 97.8872 Tm (y)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 9 0 0 9 405.234 95.1872 Tm [(Denosu)-0.8 (mab and intravenous bi)-1.5 (sphosphonates can be associate)-1.9 (d with severe )]TJ ET EMC /Span <>BDC BT 9 0 0 9 405.234 85.2872 Tm (hypocalcemia; patients with hypoparathyroidism and vitamin D deficiency are at increased ) Tj ET EMC /Span <>BDC BT 9 0 0 9 405.234 75.3872 Tm (risk.)Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 209.4998 380.6557 cm 0 0 m 0 117.88 l S Q q 1 0 0 1 606.96 498.536 cm 0 0 m 0 -117.88 l S Q 0.75 w q 1 0 0 1 226.2598 440.4261 cm 0 0 m 104.543 0 l S Q q 1 0 0 1 226.2598 392.4261 cm 0 0 m 169.329 0 l S Q /Span <>BDC BT /TT1 1 Tf 11 0 0 11 211.6598 489.5917 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 218.567 489.5917 Tm (Disease monitoring)Tj ET EMC /Span <>BDC BT 11 0 0 11 211.6598 477.5917 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 218.567 477.5917 Tm [(Consider resection \(if possible\), ablation \(eg, RF)57.2 (A, embolization, other )]TJ ET EMC /Span <>BDC BT 11 0 0 11 218.8598 465.5917 Tm (regional therapy\))Tj ET EMC /Span <>BDC BT 11 0 0 11 211.6598 453.5917 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 218.567 453.5917 Tm (Systemic therapy)Tj ET EMC /Span <>BDC BT 9 0 0 9 309.6661 457.5917 Tm (q)Tj ET EMC /Span <>BDC BT 11 0 0 11 315.1637 453.5917 Tm ( if not resectable and progressing by RECIST criteria)Tj ET EMC /Span <>BDC BT 9 0 0 9 590.8458 457.5917 Tm (t,u)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 215.2598 441.5917 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 226.2598 441.5917 Tm (Preferred Regimens)Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 235.0953 429.5917 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 229.6598 429.5917 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 238.1515 429.5917 Tm [(V)55.2 (andetanib)]TJ ET EMC /Span <>BDC BT 9 0 0 9 296.8307 433.5917 Tm (r)Tj ET EMC /Span <>BDC BT 11 0 0 11 300.3331 429.5917 Tm ( \(category 1\) )Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 235.0953 417.5917 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 229.6598 417.5917 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 238.1515 417.5917 Tm (Cabozantinib \(category 1\))Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 235.0953 405.5917 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 229.6598 405.5917 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 238.1515 405.5917 Tm (Selpercatinib \()Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 313.9484 405.5917 Tm (RET)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 335.9484 405.5917 Tm ( mutation)Tj /Span<>> BDC (-)Tj EMC (positive\))Tj ET EMC /Span <>BDC BT 9 0 0 9 434.3361 409.5917 Tm (s)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 215.2598 393.5917 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 226.2598 393.5917 Tm (Useful in Certain Circumstances)Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 235.0953 381.5917 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 229.6598 381.5917 Tm <00a1>Tj ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 238.1515 381.5917 Tm <003300480050004500550052004f004c005d00580050004400450003000b0037003000250010002b0003003e00950014001300030050005800570012003000450040000c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 9 0 0 9 436.6832 385.5917 Tm (s)Tj ET EMC endstream endobj 507 0 obj 18281 endobj %% Contents for page 47 %% Original object ID: 95 0 508 0 obj << /Length 509 0 R >> stream Q q BT /Xi45 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 509 0 obj 245 endobj %% Original object ID: 433 0 510 0 obj [ 2539 0 R 2540 0 R 2541 0 R 2542 0 R 2543 0 R 2544 0 R 2545 0 R 2546 0 R 2547 0 R 2548 0 R 2549 0 R ] endobj %% Contents for page 48 %% Original object ID: 96 0 511 0 obj << /Length 512 0 R >> stream q endstream endobj 512 0 obj 2 endobj %% Contents for page 48 %% Original object ID: 434 0 513 0 obj << /Length 514 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm [(Thyroid Carcinoma \226 )37.5 (Anaplastic Carcinoma)]TJ ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.019 Tw 11 0 0 11 23.7374 514.3517 Tm [(FNA)54.3 ( OR)17.3 ( CORE)]TJ ET EMC /Span <>BDC BT -0.035 Tw 11 0 0 11 23.7374 502.3517 Tm [(BIOPSY)35.5 ( )]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.7374 490.3517 Tm (FINDING)Tj ET EMC /Span <>BDC BT 0 Tc 0 Tw 9 0 0 9 71.4703 494.3517 Tm (a)Tj ET EMC /Span <>BDC BT 0.035 Tc -0.035 Tw 11 0 0 11 108.9134 514.3517 Tm [(DIAGNOSTIC)17.2 ( )]TJ ET EMC /Span <>BDC BT 11 0 0 11 108.9134 502.3517 Tm [(PRO)0.5 (CEDURES)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 84.2394 349.4834 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 340.5391 Tm (Anaplastic)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 328.5391 Tm (thyroid)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 316.5391 Tm (carcinoma)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 304.5391 Tm [(\(A)74 (TC\))]TJ ET EMC /Artifact <>BDC 4 M q 1 0 0 1 85.1267 326.5433 cm 0 0 m 13.566 0 l S Q q 1 0 0 1 104.1553 326.5433 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 105.0427 219.6031 cm 0 0 m 0 213.88 l S Q q 1 0 0 1 232.9327 433.4834 cm 0 0 m 0 -213.88 l S Q /Span <>BDC BT 11 0 0 11 107.2027 424.5391 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 114.1099 424.5391 Tm <0026002500260003005a004c0057004b00030047004c108700480055004800510057004c0044004f>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 107.2027 412.5391 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 114.1099 412.5391 Tm (Comprehensive )Tj ET EMC /Span <>BDC BT 11 0 0 11 114.4027 400.5391 Tm (chemistry)Tj ET EMC /Span <>BDC BT 11 0 0 11 107.2027 388.5391 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 114.1099 388.5391 Tm (TSH)Tj ET EMC /Span <>BDC BT 11 0 0 11 107.2027 376.5391 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 114.1099 376.5391 Tm (Neck ultrasound)Tj ET EMC /Span <>BDC BT 11 0 0 11 107.2027 364.5391 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 114.1099 364.5391 Tm (CT with contrast of )Tj ET EMC /Span <>BDC BT 11 0 0 11 114.4027 352.5391 Tm (head, neck, chest, )Tj ET EMC /Span <>BDC BT 11 0 0 11 114.4027 340.5391 Tm (abdomen, pelvis )Tj ET EMC /Span <>BDC BT 11 0 0 11 107.2027 328.5391 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 114.1099 328.5391 Tm [(Laryngoscopy)74.3 (, )]TJ ET EMC /Span <>BDC BT 11 0 0 11 114.4027 316.5391 Tm (including evaluation )Tj ET EMC /Span <>BDC BT 11 0 0 11 114.4027 304.5391 Tm (of vocal cord mobility)Tj ET EMC /Span <>BDC BT 11 0 0 11 107.2027 292.5391 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 114.1099 292.5391 Tm (FDG PET/CT \(skull )Tj ET EMC /Span <>BDC BT 11 0 0 11 114.4027 280.5391 Tm (base to mid-thigh\))Tj ET EMC /Span <>BDC BT 11 0 0 11 107.2027 268.5391 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 114.1099 268.5391 Tm (In case of )Tj ET EMC /Span <>BDC BT 11 0 0 11 114.4027 256.5391 Tm (airway invasion, )Tj ET EMC /Span <>BDC BT 11 0 0 11 114.4027 244.5391 Tm (bronchoscopy)Tj ET EMC /Span <>BDC BT 11 0 0 11 107.2027 232.5391 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 114.1099 232.5391 Tm (Molecular testing for )Tj ET EMC /Span <>BDC BT 11 0 0 11 114.4027 220.5391 Tm (actionable mutations)Tj ET EMC /Span <>BDC BT 9 0 0 9 224.4188 224.5391 Tm (b)Tj ET EMC /Span <>BDC BT 0.035 Tc -0.035 Tw 11 0 0 11 251.8334 514.3517 Tm [(EST)74.2 (ABLISH)17.2 ( )]TJ ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 251.8334 502.3517 Tm [(GOALS)17.5 ( )0.5 (OF)17.5 ( )]TJ ET EMC /Span <>BDC BT -0.035 Tw 11 0 0 11 251.8334 490.3517 Tm (THERAPY)Tj ET EMC /Span <>BDC BT 0 Tc 0 Tw 9 0 0 9 306.9086 494.3517 Tm (c)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 233.8201 326.5433 cm 0 0 m 8.388 0 l S Q q 1 0 0 1 247.6701 326.5433 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 248.5574 267.6031 cm 0 0 m 0 117.88 l S Q q 1 0 0 1 358.7174 385.4834 cm 0 0 m 0 -117.88 l S Q /Span <>BDC BT 11 0 0 11 250.7174 376.5391 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 257.6247 376.5391 Tm (Expedient )Tj ET EMC /Span <>BDC BT 11 0 0 11 257.9174 364.5391 Tm (consultation with )Tj ET EMC /Span <>BDC BT 11 0 0 11 257.9174 352.5391 Tm (multidisciplinary )Tj ET EMC /Span <>BDC BT 11 0 0 11 257.9174 340.5391 Tm (management team)Tj ET EMC /Span <>BDC BT 11 0 0 11 250.7175 328.5391 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 257.6247 328.5391 Tm (Discuss prognosis)Tj ET EMC /Span <>BDC BT 11 0 0 11 250.7175 316.5391 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 257.6247 316.5391 Tm (Discuss risks/)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 257.9175 304.5391 Tm <004500480051004800bf005700560003005200490003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 257.9175 292.5391 Tm (treatment options)Tj ET EMC /Span <>BDC BT 11 0 0 11 250.7175 280.5391 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 257.6247 280.5391 Tm (Discuss palliative )Tj ET EMC /Span <>BDC BT 11 0 0 11 257.9175 268.5391 Tm (care options)Tj ET EMC 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 29.5212 107.3964 cm 0 0 m 85.044 0 l S Q q 1 0 0 1 181.0886 85.3964 cm 0 0 m 85.044 0 l S Q q 1 0 0 1 29.5212 74.3964 cm 0 0 m 480.054 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 8 0 0 8 23.7612 166.456 Tm (a)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 163.456 Tm [(Consid)-0.8 (er core or open biops)-1.1 (y if FNA)55.5 ( is \223suspicious\224 for )54.7 (A)74.3 (TC or is not definitive. Morphologic diagnosis combined with immunohistochemistry is necessary in order to ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 152.456 Tm [(exclude other entities such as poorly dif)16.3 (ferentiated thyroid cancer)54 (, medullary thyroid cancer)54 (, squamous cell carcinoma, and lymphoma.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 144.456 Tm (b)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 141.456 Tm [(Molecular testing should inc)-1 (lude )]TJ ET EMC /Span <>BDC BT /TT2 1 Tf -0.037 Tw 10 0 0 10 174.6042 141.456 Tm [(BRAF)128.9 (, )-36.6 (NTRK, ALK)]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 0 Tw 10 0 0 10 256.8503 141.456 Tm (, )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 10 0 0 10 262.407 141.456 Tm (RET)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 10 0 0 10 282.407 141.456 Tm (, and tumor mutational burden.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 133.456 Tm (c)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 130.456 Tm [(Preoperative evaluations ne)-1.1 (ed to be completed as quickl)-1.2 (y as possible and involve integrated decision)]TJ /Span<>> BDC (-)Tj EMC (making in a multidisciplinary team and with the patient. Consider )Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 119.456 Tm [(referral to multidisciplinary high-volume center with expertise in treating ) 51.3 (A)74.3 (TC.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 111.456 Tm (d)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 108.456 Tm [(See Staging \(ST)55.4 (-1\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 114.5652 108.456 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 100.456 Tm (e)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm [(Resectability for locoregiona)-1.2 (l disease depends on extent )-1.5 (of involved structures, potential morbidity)72.7 (, and mortality associated with resection. In most cases, there is no )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 86.456 Tm [(indication for a debulking surgery)71.9 (. )]TJ ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 181.0886 86.456 Tm [(See Staging \(ST)54.8 (-1\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 266.1326 86.456 Tm ( for definitions of R0/R1/R2.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 78.456 Tm (f)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 75.456 Tm [(See )55.1 (Adjuvant/Radiosensitizi)-1.2 (ng Chemotherapy Regimens)-1.8 ( for )55.2 (Anaplastic )17.5 (Thyroid Carcinoma \(ANAP-A)53.9 ( [1 of 2]\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 509.575 75.456 Tm (.)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 346.419 514.3517 Tm [(ST)74.3 (AGE)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 9 0 0 9 385.2359 518.3517 Tm (d)Tj ET EMC 0 0 0 SCN 1 w q 1 0 0 1 602.9747 429.4157 cm 0 0 m 0 93.88 l S Q q 1 0 0 1 668.6107 523.296 cm 0 0 m 0 -93.88 l S Q /Span <>BDC BT 11 0 0 11 605.1346 514.3517 Tm (R0/R1 )Tj ET EMC /Span <>BDC BT 11 0 0 11 605.1346 502.3517 Tm (resection)Tj ET EMC /Span <>BDC BT 9 0 0 9 654.0438 506.3517 Tm (e)Tj ET EMC /Span <>BDC BT 11 0 0 11 605.1346 490.3517 Tm (achieved )Tj ET EMC /Span <>BDC BT 11 0 0 11 605.1346 478.3517 Tm (\(usually as )Tj ET EMC /Span <>BDC BT 11 0 0 11 605.1346 466.3517 Tm (incidentally )Tj ET EMC /Span <>BDC BT 11 0 0 11 605.1346 454.3517 Tm (discovered, )Tj ET EMC /Span <>BDC BT 11 0 0 11 605.1346 442.3517 Tm (very small )Tj ET EMC /Span <>BDC BT 11 0 0 11 605.1346 430.3517 Tm [(A)74 (TC\))]TJ ET EMC /Span <>BDC BT 11 0 0 11 499.3698 388.6882 Tm (Incomplete )Tj ET EMC /Span <>BDC BT 11 0 0 11 560.4928 388.6882 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 499.3698 376.6882 Tm (\(R2 resection\))Tj ET EMC q 1 0 0 1 683.9991 435.4157 cm 0 0 m 0 81.88 l S Q /Span <>BDC BT 11 0 0 11 686.1591 508.3517 Tm (Adjuvant EBRT/)Tj ET EMC /Span <>BDC BT 11 0 0 11 686.1591 496.3517 Tm (IMRT )Tj ET EMC /Span <>BDC BT 11 0 0 11 686.1591 484.3517 Tm (with )Tj ET EMC /Span <>BDC BT 11 0 0 11 686.1591 472.3517 Tm (radiosensitizing )Tj ET EMC /Span <>BDC BT 11 0 0 11 686.1591 460.3517 Tm (chemotherapy)Tj ET EMC /Span <>BDC BT 9 0 0 9 761.349 464.3517 Tm (f)Tj ET EMC /Span <>BDC BT 11 0 0 11 764.3461 460.3517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 686.1591 448.3517 Tm (when clinically )Tj ET EMC /Span <>BDC BT 11 0 0 11 686.1591 436.3517 Tm (appropriate)Tj ET EMC /Artifact <>BDC 4 M /GS1 gs q 1 0 0 1 669.24 476.3559 cm 0 0 m 6.812 0 l S Q q 1 0 0 1 681.5145 476.3559 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC /GS0 gs q 1 0 0 1 499.8698 350.1166 cm 0 0 m 96.803 0 l S Q q 1 0 0 1 602.1346 350.1166 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 602.9746 339.8029 cm 0 0 m 0 57.88 l S Q q 1 0 0 1 685.758 397.6832 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT 11 0 0 11 605.1346 388.7389 Tm (EBRT/)Tj ET EMC /Span <>BDC BT 11 0 0 11 605.1346 376.7389 Tm (IMRT with )Tj ET EMC /Span <>BDC BT 11 0 0 11 605.1346 364.7389 Tm (chemotherapy)Tj ET EMC /Span <>BDC BT 9 0 0 9 680.3245 368.7389 Tm (f )Tj ET EMC /Span <>BDC BT 11 0 0 11 605.1346 352.7389 Tm (when clinically )Tj ET EMC /Span <>BDC BT 11 0 0 11 605.1346 340.7389 Tm (appropriate)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 689.16 368.7431 cm 0 0 m 7.892 0 l S Q q 1 0 0 1 702.5145 368.7431 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 704.1004 321.8029 cm 0 0 m 0 93.88 l S Q /Span <>BDC BT 11 0 0 11 706.2604 406.7389 Tm (Surgery )Tj ET EMC /Span <>BDC BT 11 0 0 11 706.2604 394.7389 Tm (can be )Tj ET EMC /Span <>BDC BT 11 0 0 11 706.2604 382.7389 Tm (reconsidered )Tj ET EMC /Span <>BDC BT 11 0 0 11 706.2604 370.7389 Tm (after )Tj ET EMC /Span <>BDC BT 11 0 0 11 706.2604 358.7389 Tm (neoadjuvant )Tj ET EMC /Span <>BDC BT 11 0 0 11 706.2604 346.7389 Tm (therapy )Tj ET EMC /Span <>BDC BT 11 0 0 11 706.2604 334.7389 Tm (depending )Tj ET EMC /Span <>BDC BT 11 0 0 11 706.2604 322.7389 Tm (on response)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 381.0484 271.8849 cm 0 0 m -20.909 54.658 l -0.213 109.31 l S Q q 1 0 0 1 383 266.7833 cm 0 0 m -0.122 7.461 l -4.889 5.638 l h f Q q 1 0 0 1 382.7695 386.3032 cm 0 0 m -4.87 -5.654 l -0.097 -7.462 l h f Q EMC 10 M q 1 0 0 1 344.0656 226.5799 cm 0 0 m 0 33.88 l S Q q 1 0 0 1 415.9794 260.4602 cm 0 0 m 0 -33.88 l S Q /Span <>BDC BT 11 0 0 11 346.2256 251.5159 Tm (Stage IVC)Tj ET EMC /Span <>BDC BT 11 0 0 11 346.2256 239.5159 Tm (\(metastatic )Tj ET EMC /Span <>BDC BT 11 0 0 11 346.2256 227.5159 Tm (disease\))Tj ET EMC /Span <>BDC BT 9 0 0 9 390.2525 231.5159 Tm (c)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 418.4651 243.5201 cm 0 0 m 32.88 0 l S Q q 1 0 0 1 456.8073 243.5201 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M /GS1 gs q 1 0 0 1 461.2117 238.3503 cm 0 0 m 63.169 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn -0.037 Tw 11 0 0 11 461.2117 239.5159 Tm (See ANAP-2)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 0.035 Tc -0.035 Tw 11 0 0 11 726.1589 23.544 Tm [(ANAP)17.6 (-)35.1 (1)]TJ ET EMC 0 0 0 SCN 1 w q 1 0 0 1 344.0656 391.8885 cm 0 0 m 0 45.88 l S Q q 1 0 0 1 417.5039 437.7688 cm 0 0 m 0 -45.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 346.2256 428.8245 Tm [(Stage IV)74.4 (A)37 ( )]TJ ET EMC /Span <>BDC BT 11 0 0 11 399.4048 428.8245 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 346.2256 416.8245 Tm (or IVB)Tj ET EMC /Span <>BDC BT 9 0 0 9 378.6187 420.8245 Tm (a,c)Tj ET EMC /Span <>BDC BT 11 0 0 11 346.2256 404.8245 Tm (\(locoregional )Tj ET EMC /Span <>BDC BT 11 0 0 11 346.2256 392.8245 Tm (disease\))Tj ET EMC q 1 0 0 1 497.2098 447.4157 cm 0 0 m 0 57.88 l S Q q 1 0 0 1 585.8247 505.296 cm 0 0 m 0 -57.88 l S Q /Span <>BDC BT 11 0 0 11 499.3698 496.3517 Tm [(T)74.4 (otal )]TJ ET EMC /Span <>BDC BT 11 0 0 11 499.3698 484.3517 Tm (thyroidectomy )Tj ET EMC /Span <>BDC BT -0.004 Tw 11 0 0 11 499.3698 472.3517 Tm [(with )1 (therapeutic )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 499.3698 460.3517 Tm (lymph node )Tj ET EMC /Span <>BDC BT 11 0 0 11 499.3698 448.3517 Tm (dissection)Tj ET EMC /Artifact <>BDC 4 M q 1 0 0 1 482.2502 476.3559 cm 0 0 m 8.388 0 l S Q q 1 0 0 1 496.1002 476.3559 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 586.9546 476.3559 cm 0 0 m 9.718 0 l S Q q 1 0 0 1 602.1346 476.3559 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC /Artifact <>BDC q 1 0 0 1 525.8517 438.7041 cm 0 0 m 0 -30.762 l S Q q 1 0 0 1 525.8517 402.48 cm 0 0 m 2.552 7.012 l -2.552 7.012 l h f Q EMC /Span <>BDC BT 11 0 0 11 420.4651 472.3517 Tm (Resectable)Tj ET EMC /Span <>BDC BT 11 0 0 11 421.5143 346.1125 Tm (Unresectable)Tj ET EMC /Span <>BDC BT 9 0 0 9 490.6027 350.1125 Tm (e)Tj ET EMC /Artifact <>BDC q 1 0 0 1 439.5666 364.3526 cm 0 0 m -20.776 50.476 l -0.212 100.945 l S Q q 1 0 0 1 441.6456 359.3015 cm 0 0 m -0.309 7.456 l -5.029 5.513 l h f Q q 1 0 0 1 441.4151 470.3559 cm 0 0 m -5.009 -5.531 l -0.283 -7.457 l h f Q EMC /Artifact <>BDC /GS1 gs q 1 0 0 1 584.9552 386.6924 cm 0 0 m 11.717 0 l S Q q 1 0 0 1 602.1346 386.6924 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 0 0.397 0.645 SCN 0.75 w 10 M q 1 0 0 1 667.3646 76.2159 cm 0 0 m 67.273 0 l S Q q 1 0 0 1 667.3646 64.2159 cm 0 0 m 82.484 0 l S Q q 1 0 0 1 667.3646 52.2159 cm 0 0 m 86.786 0 l S Q q 1 0 0 1 667.3646 40.2159 cm 0 0 m 40.949 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 667.3646 77.3814 Tm (See Disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 667.3646 65.3814 Tm (Monitoring and )Tj ET EMC /Span <>BDC BT 11 0 0 11 667.3646 53.3814 Tm (Management on )Tj ET EMC /Span <>BDC BT 11 0 0 11 667.3646 41.3814 Tm (ANAP)Tj /Span<>> BDC (-)Tj EMC (2)Tj ET EMC endstream endobj 514 0 obj 21331 endobj %% Contents for page 48 %% Original object ID: 97 0 515 0 obj << /Length 516 0 R >> stream Q q BT /Xi46 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 516 0 obj 245 endobj %% Original object ID: 436 0 517 0 obj [ 2550 0 R 2551 0 R 2552 0 R 2553 0 R 2554 0 R 2555 0 R 2556 0 R 2557 0 R 2558 0 R 2559 0 R 2560 0 R ] endobj %% Contents for page 49 %% Original object ID: 98 0 518 0 obj << /Length 519 0 R >> stream q endstream endobj 519 0 obj 2 endobj %% Contents for page 49 %% Original object ID: 437 0 520 0 obj << /Length 521 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm [(Thyroid Carcinoma \226 )37.5 (Anaplastic Carcinoma)]TJ ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 726.1589 23.544 Tm [(ANAP)17.6 (-)35.1 (2)]TJ ET EMC /Span <>BDC BT 0.034 Tc -0.034 Tw 11 0 0 11 23.7374 514.28 Tm [(MET)74.4 (AST)74.4 (A)74.1 (TIC)16.2 ( )]TJ ET EMC /Span <>BDC BT 0.035 Tc -0.035 Tw 11 0 0 11 23.7374 502.28 Tm (DISEASE)Tj ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 350.2091 Tm (Stage )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 338.2091 Tm (IVC)Tj ET EMC /Span <>BDC BT 9 0 0 9 41.8809 342.2091 Tm (d)Tj ET EMC /Span <>BDC BT 11 0 0 11 66.4948 422.1875 Tm (Aggressive therapy)Tj ET EMC /Span <>BDC BT -0.017 Tw 11 0 0 11 66.4948 267.4129 Tm (Palliative care)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 80.8208 285.8909 cm 0 0 m -24.229 62.322 l -0.247 124.638 l S Q q 1 0 0 1 82.8 280.8 cm 0 0 m -0.163 7.46 l -4.919 5.611 l h f Q q 1 0 0 1 82.5357 415.6265 cm 0 0 m -4.9 -5.628 l -0.137 -7.461 l h f Q EMC /Artifact <>BDC q 1 0 0 1 149 271.4171 cm 0 0 m 34.672 0 l S Q q 1 0 0 1 189.1337 271.4171 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 194.1371 355.2515 cm 0 0 m 0 141.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 229.3804 403.022 cm 0 0 m 81.479 0 l S Q /Span <>BDC BT /GS0 gs 0 Tw 11 0 0 11 196.2971 488.1875 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 203.2043 488.1875 Tm [(T)74.4 (otal thyroidectomy with )]TJ ET EMC /Span <>BDC BT 11 0 0 11 203.4971 476.1875 Tm (therapeutic lymph node )Tj ET EMC /Span <>BDC BT 11 0 0 11 203.4971 464.1875 Tm (dissection if resectable )Tj ET EMC /Span <>BDC BT 11 0 0 11 203.4971 452.1875 Tm (\(R0/R1\))Tj ET EMC /Span <>BDC BT 11 0 0 11 196.2971 440.1875 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 203.2043 440.1875 Tm (Locoregional radiation )Tj ET EMC /Span <>BDC BT 11 0 0 11 203.4971 428.1875 Tm (therapy)Tj ET EMC /Span <>BDC BT 11 0 0 11 196.2971 416.1875 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 203.2043 416.1875 Tm (Systemic therapy )Tj ET EMC /Span <>BDC BT 11 0 0 11 297.3596 416.1875 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 203.4971 404.1875 Tm (\(See )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs /C2_0 1 Tf 11 0 0 11 229.3804 404.1875 Tm <0024003100240033>Tj /Span<>> BDC <0010>Tj EMC [<0024>36.4 <0003003e0015000300520049000300160040>]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 11 0 0 11 310.8599 404.1875 Tm (\))Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 199.8971 392.1875 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 210.8971 392.1875 Tm (Molecular testing for )Tj ET EMC /Span <>BDC BT 11 0 0 11 210.6971 380.1875 Tm (actionable mutations)Tj ET EMC /Span <>BDC BT 9 0 0 9 320.7132 384.1875 Tm (g)Tj ET EMC /Span <>BDC BT 11 0 0 11 326.2108 380.1875 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 329.2669 380.1875 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 210.6971 368.1875 Tm (if not previously done)Tj ET EMC /Span <>BDC BT 9 0 0 9 324.9832 372.1875 Tm (b)Tj ET EMC /Span <>BDC BT 11 0 0 11 196.2971 356.1875 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 203.2043 356.1875 Tm (Consider clinical trial)Tj ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 171.2154 426.1917 cm 0 0 m 12.456 0 l S Q q 1 0 0 1 189.1337 426.1917 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 194.1371 212.4769 cm 0 0 m 0 117.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 203.2043 248.2474 cm 0 0 m 116.751 0 l S Q q 1 0 0 1 203.4971 236.2474 cm 0 0 m 105.746 0 l S Q q 1 0 0 1 203.4971 224.2474 cm 0 0 m 85.604 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 196.2971 321.4129 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 203.2043 321.4129 Tm (Palliative locoregional )Tj ET EMC /Span <>BDC BT 11 0 0 11 203.4971 309.4129 Tm (radiation therapy)Tj ET EMC /Span <>BDC BT 11 0 0 11 196.2971 297.4129 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 203.2043 297.4129 Tm (Local lesion control with )Tj ET EMC /Span <>BDC BT 11 0 0 11 203.4971 285.4129 Tm (surgery or radiation )Tj ET EMC /Span <>BDC BT 11 0 0 11 203.4971 273.4129 Tm (\(eg, bone,)Tj ET EMC /Span <>BDC BT 9 0 0 9 255.4409 277.4129 Tm (h)Tj ET EMC /Span <>BDC BT 11 0 0 11 260.9385 273.4129 Tm ( brain )Tj ET EMC /Span <>BDC BT 11 0 0 11 203.4971 261.4129 Tm (metastases\))Tj ET EMC /Span <>BDC BT 11 0 0 11 196.2971 249.4129 Tm <9520>Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 203.2043 249.4129 Tm (See NCCN Guidelines )Tj ET EMC /Span <>BDC BT 11 0 0 11 203.4971 237.4129 Tm (for Central Nervous )Tj ET EMC /Span <>BDC BT 11 0 0 11 203.4971 225.4129 Tm (System Cancers)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 196.2971 213.4129 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 203.2043 213.4129 Tm (Best supportive care)Tj ET EMC /GS1 gs q 1 0 0 1 29.5212 151.3964 cm 0 0 m 85.044 0 l S Q q 1 0 0 1 29.5212 74.3964 cm 0 0 m 329.39 0 l S Q /Span <>BDC BT /GS0 gs /TT0 1 Tf 8 0 0 8 23.7612 166.456 Tm (b)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 163.456 Tm [(Molecular testing should inc)-1 (lude )]TJ ET EMC /Span <>BDC BT /TT2 1 Tf -0.037 Tw 10 0 0 10 174.6042 163.456 Tm [(BRAF)128.9 (, )-36.6 (NTRK, ALK)]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 0 Tw 10 0 0 10 256.8503 163.456 Tm (, )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 10 0 0 10 262.407 163.456 Tm (RET)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 10 0 0 10 282.407 163.456 Tm (, and tumor mutational burden.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 155.456 Tm (d)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 152.456 Tm [(See Staging \(ST)55.4 (-1)]TJ ET EMC /Span <>BDC BT 10 0 0 10 111.2351 152.456 Tm (\))Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 114.5652 152.456 Tm (.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 144.456 Tm (g)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 141.456 Tm [(Consid)-0.8 (er dabrafenib/trametinib if )]TJ ET EMC /Span <>BDC BT /TT2 1 Tf 10 0 0 10 176.821 141.456 Tm (BRAF)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 10 0 0 10 203.491 141.456 Tm [( V600E mutation positive [Subbiah V)90.8 (, et al. J Clin Oncol 2018;36\(1\):7-13]; larotrectinib or entrectinib if ) ]TJ ET EMC /Span <>BDC BT /TT2 1 Tf 10 0 0 10 653.9255 141.456 Tm (NTRK )Tj ET EMC /Span <>BDC BT /TT0 1 Tf 10 0 0 10 683.9255 141.456 Tm (gene fusion )Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 130.456 Tm [(positive [Drilon )54.2 (A, et al. N Engl J Med 2018;378\(8\):731-739; Doebele RC, et al. Lancet Oncol 2020;21:271) ]TJ /Span<>> BDC (-)Tj EMC (282]; selpercatinib if )Tj ET EMC /Span <>BDC BT /TT2 1 Tf 10 0 0 10 592.6316 130.456 Tm (RET)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 10 0 0 10 612.6316 130.456 Tm ( fusion positive \(Wirth L, et )Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 119.456 Tm [(al. Presented at the )55 (Annual Meeting of the European Society for Medical Oncology in Barcelona, Spain; September 27) ]TJ /Span<>> BDC (-)Tj EMC (October 1, 2019. Oral presentation.\) or )Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 108.456 Tm [(pembrolizumab for )17 (TMB)]TJ /Span<>> BDC (-)Tj EMC [(H \(Marabelle )54.4 (A, et al. Presented at the )55.5 (Annual Meeting of ESMO in Barcelona, Spain; September 30, 2019\).)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 100.456 Tm (h)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm [(Consid)-0.8 (er use of intravenous)-0.6 ( bisphosphonates or denosumab. Denosumab and intravenous bisphosphonates can be associated with severe hypocalcemia; patients ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 86.456 Tm (with hypoparathyroidism and vitamin D deficiency are at increased risk. ) Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 78.456 Tm (i)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 10 0 0 10 29.5212 75.456 Tm (See )Tj ET EMC /Span <>BDC BT 10 0 0 10 50.0925 75.456 Tm [(Systemic )18.2 (Therapy Regi)-1 (mens for Metastatic Disease )-0.6 (\(ANAP)]TJ /Span<>> BDC (-)Tj EMC [(A)55 ( [2 of 2]\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 10 0 0 10 358.9109 75.456 Tm (.)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 0.035 Tc -0.017 Tw 11 0 0 11 406.1395 514.28 Tm [(DISEASE)17.5 ( )0.6 (MONIT)18.1 (ORING)17.6 ( )37.7 (AND)17.3 ( )0.6 (MANAGEMENT)]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 335.7154 496.24 cm 0 0 m 0 -282.827 l S Q EMC /Artifact <>BDC q 1 0 0 1 343.3252 354.8265 cm 0 0 m 53.433 0 l S Q q 1 0 0 1 402.2208 354.8265 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC 10 M q 1 0 0 1 407.1706 307.8863 cm 0 0 m 0 93.88 l S Q q 1 0 0 1 562.0228 401.7666 cm 0 0 m 0 -93.88 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 409.3306 392.8223 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 416.2379 392.8223 Tm (Cross-sectional imaging )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.5306 380.8223 Tm (\(CT or MRI with contrast\) )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.5306 368.8223 Tm (of brain, neck, chest, )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.5306 356.8223 Tm (abdomen, and pelvis )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.5306 344.8223 Tm (at frequent intervals as )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.5306 332.8223 Tm (clinically indicated)Tj ET EMC /Span <>BDC BT 11 0 0 11 409.3306 320.8223 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 416.2379 320.8223 Tm (Consider FDG PET/CT 3\2266 )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.5306 308.8223 Tm (months after initial therapy)Tj ET EMC q 1 0 0 1 623.8025 289.8863 cm 0 0 m 0 129.88 l S Q 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 632.8697 313.6568 cm 0 0 m 131.522 0 l S Q q 1 0 0 1 633.1625 301.6568 cm 0 0 m 75.211 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 625.9625 410.8223 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 632.8697 410.8223 Tm (Continued disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 633.1625 398.8223 Tm (monitoring if NED)Tj ET EMC /Span <>BDC BT 11 0 0 11 625.9625 386.8223 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 632.8697 386.8223 Tm (Palliative locoregional )Tj ET EMC /Span <>BDC BT 11 0 0 11 633.1625 374.8223 Tm (radiation therapy)Tj ET EMC /Span <>BDC BT 11 0 0 11 625.9625 362.8223 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 632.8697 362.8223 Tm (Local lesion control \(eg, )Tj ET EMC /Span <>BDC BT 11 0 0 11 633.1625 350.8223 Tm (bone,)Tj ET EMC /Span <>BDC BT 9 0 0 9 662.494 354.8223 Tm (h)Tj ET EMC /Span <>BDC BT -0.009 Tw 11 0 0 11 667.9916 350.8223 Tm ( brain metastases\))Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 625.9625 338.8223 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 632.8697 338.8223 Tm (Second-line systemic )Tj ET EMC /Span <>BDC BT 11 0 0 11 633.1625 326.8223 Tm (therapy)Tj ET EMC /Span <>BDC BT 9 0 0 9 672.8978 330.8223 Tm (i)Tj ET EMC /Span <>BDC BT 11 0 0 11 675.3983 326.8223 Tm ( or clinical trial)Tj ET EMC /Span <>BDC BT 11 0 0 11 625.9625 314.8223 Tm <9520>Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 632.8697 314.8223 Tm (See NCCN Guidelines for )Tj ET EMC /Span <>BDC BT 11 0 0 11 633.1625 302.8223 Tm (Palliative Care)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 625.9625 290.8223 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 632.8697 290.8223 Tm (Best supportive care)Tj ET EMC /Span <>BDC BT 0.035 Tc -0.035 Tw 11 0 0 11 196.4904 514.28 Tm [(TREA)73.9 (TMENT)]TJ ET EMC /Artifact <>BDC 0 0 0 SCN 1 w 4 M q 1 0 0 1 566.9726 354.8265 cm 0 0 m 46.418 0 l S Q q 1 0 0 1 618.8526 354.8265 cm 0 0 m -7.012 2.552 l -7.012 -2.552 l h f Q EMC endstream endobj 521 0 obj 16540 endobj %% Contents for page 49 %% Original object ID: 99 0 522 0 obj << /Length 523 0 R >> stream Q q BT /Xi47 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 523 0 obj 245 endobj %% Original object ID: 439 0 524 0 obj [ 2561 0 R 2562 0 R 2563 0 R 2564 0 R ] endobj %% Contents for page 50 %% Original object ID: 100 0 525 0 obj << /Length 526 0 R >> stream q endstream endobj 526 0 obj 2 endobj %% Contents for page 50 %% Original object ID: 440 0 527 0 obj << /Length 528 0 R >> stream /Span <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 8 0 0 8 23.7612 89.456 Tm (1)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 86.456 Tm [(Adapted with permission fro)-0.7 (m Mary )55.4 (Ann Liebert, Inc., Smallridge RC, et al. )54.6 (American )17.6 (Thyroid )54.9 (Association guidelines for management of patients with anaplastic thyroid ) ]TJ ET EMC /Span <>BDC BT -0.018 Tw 10 0 0 10 29.5212 75.456 Tm [(cancer)54.7 (. Thyroid )-18.3 (2012;22:1)73.5 (124. )]TJ ET EMC 0.877 0.91 0.92 scn /GS1 gs 81.141 501.78 629.719 -16.008 re 81.141 485.772 629.719 -16.008 re f /CS0 CS 0 0 0 SCN /GS2 gs q 1 0 0 1 80.6406 501.78 cm 0 0 m 153.417 0 l S Q q 1 0 0 1 81.1406 486.2717 cm 0 0 m 0 15.008 l S Q q 1 0 0 1 234.0574 501.78 cm 0 0 m 362.822 0 l S Q q 1 0 0 1 596.8794 501.78 cm 0 0 m 114.48 0 l S Q q 1 0 0 1 710.8594 486.2717 cm 0 0 m 0 15.008 l S Q q 1 0 0 1 80.6406 485.7717 cm 0 0 m 153.417 0 l S Q q 1 0 0 1 81.1406 470.2634 cm 0 0 m 0 15.008 l S Q q 1 0 0 1 234.0574 485.7717 cm 0 0 m 362.822 0 l S Q q 1 0 0 1 596.8794 485.7717 cm 0 0 m 114.48 0 l S Q q 1 0 0 1 710.8594 470.2634 cm 0 0 m 0 15.008 l S Q q 1 0 0 1 80.6406 469.7634 cm 0 0 m 153.417 0 l S Q q 1 0 0 1 81.1406 430.2551 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 234.0574 469.7634 cm 0 0 m 362.822 0 l S Q q 1 0 0 1 234.0574 430.2551 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 596.8794 430.2551 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 710.8594 430.2551 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 80.6406 429.7551 cm 0 0 m 153.417 0 l S Q q 1 0 0 1 81.1406 390.2468 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 234.0574 429.7551 cm 0 0 m 362.822 0 l S Q q 1 0 0 1 234.0574 390.2468 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 596.8794 429.7551 cm 0 0 m 114.48 0 l S Q q 1 0 0 1 596.8794 390.2468 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 710.8594 390.2468 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 80.6406 389.7468 cm 0 0 m 153.417 0 l S Q q 1 0 0 1 81.1406 350.2385 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 234.0574 389.7468 cm 0 0 m 362.822 0 l S Q q 1 0 0 1 234.0574 350.2385 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 596.8794 389.7468 cm 0 0 m 114.48 0 l S Q q 1 0 0 1 596.8794 350.2385 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 710.8594 350.2385 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 80.6406 349.7385 cm 0 0 m 153.417 0 l S Q q 1 0 0 1 81.1406 306.5 cm 0 0 m 0 42.738 l S Q q 1 0 0 1 234.0574 349.7385 cm 0 0 m 362.822 0 l S Q q 1 0 0 1 234.0574 306.5 cm 0 0 m 0 42.738 l S Q q 1 0 0 1 596.8794 349.7385 cm 0 0 m 114.48 0 l S Q q 1 0 0 1 596.8794 306.5 cm 0 0 m 0 42.738 l S Q q 1 0 0 1 710.8594 306.5 cm 0 0 m 0 42.738 l S Q q 1 0 0 1 80.6406 306 cm 0 0 m 153.417 0 l S Q q 1 0 0 1 81.1406 266.4917 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 234.0574 306 cm 0 0 m 362.822 0 l S Q q 1 0 0 1 234.0574 266.4917 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 596.8794 306 cm 0 0 m 114.48 0 l S Q q 1 0 0 1 596.8794 266.4917 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 710.8594 266.4917 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 80.6406 265.9917 cm 0 0 m 153.417 0 l S Q q 1 0 0 1 234.0574 265.9917 cm 0 0 m 362.822 0 l S Q q 1 0 0 1 596.8794 265.9917 cm 0 0 m 114.48 0 l S Q q 1 0 0 1 596.8794 469.7634 cm 0 0 m 114.48 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0 Tw 11 0 0 11 256.8916 489.7717 Tm (Adjuvant/Radiosensitizing Chemotherapy Regimens)Tj ET EMC /Span <>BDC BT 9 0 0 9 530.103 493.7717 Tm (1)Tj ET EMC 0.75 w q 1 0 0 1 85.1406 472.5978 cm 0 0 m 166.875 0 l S Q /Span <>BDC BT 11 0 0 11 85.1406 473.7634 Tm (Other Recommended Regimens)Tj ET EMC /Span <>BDC BT 11 0 0 11 85.1406 445.7551 Tm (Paclitaxel/carboplatin)Tj ET EMC /Span <>BDC BT 11 0 0 11 238.0574 445.7551 Tm (Paclitaxel 50 mg/m)Tj ET EMC /Span <>BDC BT 6.413 0 0 6.413 336.4988 449.4181 Tm (2)Tj ET EMC /Span <>BDC BT 11 0 0 11 340.0654 445.7551 Tm [(, carboplatin )38 (AUC 2 IV)]TJ ET EMC /Span <>BDC BT 11 0 0 11 600.8794 445.7551 Tm [(W)18.2 (eekly)]TJ ET EMC /Span <>BDC BT 11 0 0 11 85.1406 405.7468 Tm (Docetaxel/doxorubicin)Tj ET EMC /Span <>BDC BT 11 0 0 11 238.0574 417.7468 Tm (Docetaxel 60 mg/m)Tj ET EMC /Span <>BDC BT 6.413 0 0 6.413 337.7127 421.4098 Tm (2)Tj ET EMC /Span <>BDC BT 11 0 0 11 341.2793 417.7468 Tm [( IV)92.1 (, doxorubicin 60 mg/m)]TJ ET EMC /Span <>BDC BT 6.413 0 0 6.413 470.4595 421.4098 Tm (2)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 474.0261 417.7468 Tm <0003002c00390003000b005a004c0057004b000300530048004a00bf004f004a0055004400560057004c0050000c>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 591.9753 417.7468 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 238.0574 405.7468 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 238.0574 393.7468 Tm (Docetaxel 20 mg/m)Tj ET EMC /Span <>BDC BT 6.413 0 0 6.413 337.7127 397.4098 Tm (2)Tj ET EMC /Span <>BDC BT 11 0 0 11 341.2793 393.7468 Tm [( IV)92.1 (, doxorubicin 20 mg/m)]TJ ET EMC /Span <>BDC BT 6.413 0 0 6.413 470.4595 397.4098 Tm (2)Tj ET EMC /Span <>BDC BT 11 0 0 11 474.0261 393.7468 Tm ( IV)Tj ET EMC /Span <>BDC BT 11 0 0 11 600.8794 417.7468 Tm (Every 3\2264 weeks)Tj ET EMC /Span <>BDC BT 11 0 0 11 688.3423 417.7468 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 600.8794 393.7468 Tm [(W)18.2 (eekly)]TJ ET EMC /Span <>BDC BT 11 0 0 11 85.1406 365.7385 Tm (Paclitaxel)Tj ET EMC /Span <>BDC BT 11 0 0 11 238.0574 365.7385 Tm (30\22660 mg/m)Tj ET EMC /Span <>BDC BT 6.413 0 0 6.413 301.0389 369.4015 Tm (2)Tj ET EMC /Span <>BDC BT 11 0 0 11 304.6055 365.7385 Tm ( IV)Tj ET EMC /Span <>BDC BT 11 0 0 11 600.8794 365.7385 Tm [(W)18.2 (eekly)]TJ ET EMC /Span <>BDC BT 11 0 0 11 85.1406 323.8651 Tm (Cisplatin)Tj ET EMC /Span <>BDC BT 11 0 0 11 238.0574 323.8651 Tm (30\22640 mg/m)Tj ET EMC /Span <>BDC BT 6.413 0 0 6.413 301.0389 327.528 Tm (2)Tj ET EMC /Span <>BDC BT 11 0 0 11 304.6055 323.8651 Tm ( IV)Tj ET EMC /Span <>BDC BT 11 0 0 11 600.8794 323.8651 Tm [(W)18.2 (eekly)]TJ ET EMC /Span <>BDC BT 11 0 0 11 85.1406 281.9917 Tm (Doxorubicin)Tj ET EMC /Span <>BDC BT 11 0 0 11 238.0574 293.9917 Tm (60 mg/m)Tj ET EMC /Span <>BDC BT 6.413 0 0 6.413 282.6859 297.6547 Tm (2)Tj ET EMC /Span <>BDC BT 11 0 0 11 286.2524 293.9917 Tm ( IV)Tj ET EMC /Span <>BDC BT 11 0 0 11 238.0574 281.9917 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 238.0574 269.9917 Tm (20 mg/m)Tj ET EMC /Span <>BDC BT 6.413 0 0 6.413 282.6859 273.6547 Tm (2)Tj ET EMC /Span <>BDC BT 11 0 0 11 286.2524 269.9917 Tm ( IV)Tj ET EMC /Span <>BDC BT 11 0 0 11 600.8794 293.9917 Tm (Every 3 weeks)Tj ET EMC /Span <>BDC BT 11 0 0 11 600.8794 269.9917 Tm [(W)18.2 (eekly)]TJ ET EMC /Artifact <>BDC BT /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g 0 G 1 w /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm [(Thyroid Carcinoma \226 )37.5 (Anaplastic Carcinoma)]TJ ET EMC 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 724.3486 35.544 Tm [(ANAP)17.5 (-)17.4 (A)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 734.0595 23.544 Tm [(1 )-17.6 (O)-35 (F)-17.4 ( 3)]TJ ET EMC /GS1 gs q 1 0 0 1 44.5366 162.019 cm 0 0 m 328.083 0 l S Q /Span <>BDC BT /GS0 gs 11 0 0 11 23.7612 163.1845 Tm (For )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 44.5366 163.1845 Tm [(Systemic Therapies for Metastatic Disease see )35.5 (ANAP)]TJ /Span<>> BDC (-)Tj EMC [(A)36.5 ( \(2 of 3\))]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 372.6191 163.1845 Tm (.)Tj ET EMC /Span <>BDC BT 0.035 Tc -0.017 Tw 11 0 0 11 337.4685 514.3517 Tm [(SYSTEMIC)17.2 ( )0.6 (THERAPY)]TJ ET EMC endstream endobj 528 0 obj 10261 endobj %% Contents for page 50 %% Original object ID: 101 0 529 0 obj << /Length 530 0 R >> stream Q q BT /Xi48 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 530 0 obj 245 endobj %% Original object ID: 441 0 531 0 obj << /AIS false /BM /Normal /CA 1 /OP true /OPM 0 /SA false /SMask /None /Type /ExtGState /ca 1 /op true >> endobj %% Original object ID: 443 0 532 0 obj [ 2565 0 R 2566 0 R 2567 0 R 2568 0 R ] endobj %% Contents for page 51 %% Original object ID: 102 0 533 0 obj << /Length 534 0 R >> stream q endstream endobj 534 0 obj 2 endobj %% Contents for page 51 %% Original object ID: 444 0 535 0 obj << /Length 536 0 R >> stream /CS0 CS 0 0 0 SCN /GS0 gs q 1 0 0 1 52.589 331.8439 cm 0 0 m 226.799 0 l S Q q 1 0 0 1 53.089 292.3356 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 279.3884 331.8439 cm 0 0 m 362.822 0 l S Q q 1 0 0 1 279.3884 292.3356 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 642.2103 292.3356 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 738.911 292.3356 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 52.589 291.8356 cm 0 0 m 226.799 0 l S Q q 1 0 0 1 53.089 252.3273 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 279.3884 291.8356 cm 0 0 m 362.822 0 l S Q q 1 0 0 1 279.3884 252.3273 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 642.2103 291.8356 cm 0 0 m 97.201 0 l S Q q 1 0 0 1 642.2103 252.3273 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 738.911 252.3273 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 52.589 251.8273 cm 0 0 m 226.799 0 l S Q q 1 0 0 1 53.089 212.319 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 279.3884 251.8273 cm 0 0 m 362.822 0 l S Q q 1 0 0 1 279.3884 212.319 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 642.2103 251.8273 cm 0 0 m 97.201 0 l S Q q 1 0 0 1 642.2103 212.319 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 738.911 212.319 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 52.589 211.819 cm 0 0 m 226.799 0 l S Q q 1 0 0 1 53.089 172.3107 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 279.3884 211.819 cm 0 0 m 362.822 0 l S Q q 1 0 0 1 279.3884 172.3107 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 642.2103 211.819 cm 0 0 m 97.201 0 l S Q q 1 0 0 1 642.2103 172.3107 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 738.911 172.3107 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 52.589 171.8107 cm 0 0 m 226.799 0 l S Q q 1 0 0 1 279.3884 171.8107 cm 0 0 m 362.822 0 l S Q q 1 0 0 1 642.2103 171.8107 cm 0 0 m 97.201 0 l S Q q 1 0 0 1 642.2103 331.8439 cm 0 0 m 97.201 0 l S Q /Span <>BDC BT /CS0 cs 0 0 0 scn /GS1 gs /TT0 1 Tf 11 0 0 11 57.0891 307.8356 Tm (Paclitaxel/carboplatin)Tj ET EMC /Span <>BDC BT 9 0 0 9 170.1882 311.8356 Tm (1)Tj ET EMC /Span <>BDC BT 11 0 0 11 283.3884 319.8356 Tm (Paclitaxel 60\226100 mg/m)Tj ET EMC /Span <>BDC BT 6.413 0 0 6.413 406.3005 323.4986 Tm (2)Tj ET EMC /Span <>BDC BT 11 0 0 11 409.8671 319.8356 Tm [(, carboplatin )38 (AUC 2 IV)]TJ ET EMC /Span <>BDC BT 11 0 0 11 283.3884 307.8356 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 283.3884 295.8356 Tm (Paclitaxel 135\226175 mg/m)Tj ET EMC /Span <>BDC BT 6.413 0 0 6.413 412.4182 299.4986 Tm (2)Tj ET EMC /Span <>BDC BT 11 0 0 11 415.9848 295.8356 Tm [(, carboplatin )38 (AUC 5\2266 IV)]TJ ET EMC /Span <>BDC BT 11 0 0 11 646.2104 319.8356 Tm [(W)18.2 (eekly)]TJ ET EMC /Span <>BDC 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<>BDC BT 11 0 0 11 646.2104 215.819 Tm (Every 3\2264 weeks)Tj ET EMC /Span <>BDC BT 11 0 0 11 57.0891 187.8107 Tm (Doxorubicin)Tj ET EMC /Span <>BDC BT 9 0 0 9 121.2575 191.8107 Tm (1)Tj ET EMC /Span <>BDC BT 11 0 0 11 283.3884 199.8107 Tm (60\22675 mg/m)Tj ET EMC /Span <>BDC BT 6.413 0 0 6.413 346.3699 203.4737 Tm (2)Tj ET EMC /Span <>BDC BT 11 0 0 11 349.9365 199.8107 Tm ( IV)Tj ET EMC /Span <>BDC BT 11 0 0 11 283.3884 187.8107 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 283.3884 175.8107 Tm (20 mg/m)Tj ET EMC /Span <>BDC BT 6.413 0 0 6.413 328.0168 179.4737 Tm (2)Tj ET EMC /Span <>BDC BT 11 0 0 11 331.5834 175.8107 Tm ( IV)Tj ET EMC /Span <>BDC BT 11 0 0 11 646.2104 199.8107 Tm (Every 3 weeks)Tj ET EMC /Span <>BDC BT 11 0 0 11 646.2104 175.8107 Tm [(W)18.2 (eekly)]TJ ET EMC /Artifact <>BDC BT /TT1 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g 0 G /GS2 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT0 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm [(Thyroid Carcinoma \226 )37.5 (Anaplastic Carcinoma)]TJ ET EMC 0 0.397 0.645 SCN 0.75 w /GS2 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT1 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS1 gs /TT0 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 724.3486 35.544 Tm [(ANAP)17.5 (-)17.4 (A)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 734.0595 23.544 Tm [(2 )-17.6 (O)-35 (F)-17.4 ( 3)]TJ ET EMC /Span <>BDC BT 0.035 Tc -0.017 Tw 11 0 0 11 337.4685 518.3517 Tm [(SYSTEMIC)17.2 ( )0.6 (THERAPY)]TJ ET EMC 0.877 0.91 0.92 scn /GS2 gs 52.988 513.902 685.88 -16.008 re 52.988 497.894 685.88 -16.008 re 52.988 347.852 685.88 -16.008 re f 0 0 0 SCN 1 w /GS0 gs q 1 0 0 1 52.4883 513.902 cm 0 0 m 227.519 0 l S Q q 1 0 0 1 52.9883 498.3937 cm 0 0 m 0 15.008 l S Q q 1 0 0 1 280.0077 513.902 cm 0 0 m 362.16 0 l S Q q 1 0 0 1 642.1677 513.902 cm 0 0 m 97.201 0 l S Q q 1 0 0 1 738.8683 498.3937 cm 0 0 m 0 15.008 l S Q q 1 0 0 1 52.4883 497.8937 cm 0 0 m 227.519 0 l S Q q 1 0 0 1 52.9883 482.3854 cm 0 0 m 0 15.008 l S Q q 1 0 0 1 280.0077 497.8937 cm 0 0 m 362.16 0 l S Q q 1 0 0 1 642.1677 497.8937 cm 0 0 m 97.201 0 l S Q q 1 0 0 1 738.8683 482.3854 cm 0 0 m 0 15.008 l S Q q 1 0 0 1 52.9883 442.3771 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 280.0077 442.3771 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 642.1677 442.3771 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 738.8683 442.3771 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 52.4883 441.8771 cm 0 0 m 227.519 0 l S Q q 1 0 0 1 52.9883 415.3688 cm 0 0 m 0 26.008 l S Q q 1 0 0 1 280.0077 441.8771 cm 0 0 m 362.16 0 l S Q q 1 0 0 1 280.0077 415.3688 cm 0 0 m 0 26.008 l S Q q 1 0 0 1 642.1677 441.8771 cm 0 0 m 97.201 0 l S Q q 1 0 0 1 642.1677 415.3688 cm 0 0 m 0 26.008 l S Q q 1 0 0 1 738.8683 415.3688 cm 0 0 m 0 26.008 l S Q q 1 0 0 1 52.4883 414.8688 cm 0 0 m 227.519 0 l S Q q 1 0 0 1 52.9883 388.3605 cm 0 0 m 0 26.008 l S Q q 1 0 0 1 280.0077 414.8688 cm 0 0 m 362.16 0 l S Q q 1 0 0 1 280.0077 388.3605 cm 0 0 m 0 26.008 l S Q q 1 0 0 1 642.1677 414.8688 cm 0 0 m 97.201 0 l S Q q 1 0 0 1 642.1677 388.3605 cm 0 0 m 0 26.008 l S Q q 1 0 0 1 738.8683 388.3605 cm 0 0 m 0 26.008 l S Q q 1 0 0 1 52.4883 387.8605 cm 0 0 m 227.519 0 l S Q q 1 0 0 1 52.9883 348.3522 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 280.0077 387.8605 cm 0 0 m 362.16 0 l S Q q 1 0 0 1 280.0077 348.3522 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 642.1677 387.8605 cm 0 0 m 97.201 0 l S Q q 1 0 0 1 642.1677 348.3522 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 738.8683 348.3522 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 52.4883 347.8522 cm 0 0 m 227.519 0 l S Q q 1 0 0 1 52.9883 332.3439 cm 0 0 m 0 15.008 l S Q q 1 0 0 1 280.0077 347.8522 cm 0 0 m 362.16 0 l S Q q 1 0 0 1 642.1677 347.8522 cm 0 0 m 97.201 0 l S Q q 1 0 0 1 738.8683 332.3439 cm 0 0 m 0 15.008 l S Q q 1 0 0 1 52.4883 331.8439 cm 0 0 m 227.519 0 l S Q q 1 0 0 1 280.0077 331.8439 cm 0 0 m 362.16 0 l S Q q 1 0 0 1 642.1677 331.8439 cm 0 0 m 97.201 0 l S Q q 1 0 0 1 52.4883 481.8854 cm 0 0 m 227.519 0 l S Q q 1 0 0 1 280.0077 481.8854 cm 0 0 m 362.16 0 l S Q q 1 0 0 1 642.1677 481.8854 cm 0 0 m 97.201 0 l S Q /Span <>BDC BT 0 0 0 scn /GS1 gs 0 Tc 0 Tw 11 0 0 11 261.428 501.8937 Tm (Systemic Therapy Regimens for Metastatic 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124.2183 433.8688 Tm (3)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 10 0 0 10 56.9883 418.8688 Tm (\()Tj ET EMC /Span <>BDC BT /TT2 1 Tf 10 0 0 10 60.3184 418.8688 Tm (NTRK)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 10 0 0 10 87.54 418.8688 Tm ( gene fusion positive\))Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 284.0077 424.3688 Tm (100 mg PO)Tj ET EMC /Span <>BDC BT 11 0 0 11 646.1677 424.3688 Tm [(T)74.4 (wice daily)]TJ ET EMC /Span <>BDC BT 11 0 0 11 56.9883 402.8605 Tm (Entrectinib)Tj ET EMC /Span <>BDC BT 9 0 0 9 114.4375 406.8605 Tm (4)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 10 0 0 10 56.9883 391.8605 Tm (\()Tj ET EMC /Span <>BDC BT /TT2 1 Tf 10 0 0 10 60.3184 391.8605 Tm (NTRK)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 10 0 0 10 87.54 391.8605 Tm ( gene fusion positive\))Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 284.0077 397.3605 Tm (600 mg PO)Tj ET EMC /Span <>BDC BT 11 0 0 11 646.1677 397.3605 Tm (Once daily)Tj ET EMC /Span <>BDC BT 11 0 0 11 56.9883 369.3522 Tm (Selpercatinib)Tj ET EMC /Span <>BDC BT 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279.2877 171.4605 cm 0 0 m 362.736 0 l S Q q 1 0 0 1 642.0237 171.4605 cm 0 0 m 97.488 0 l S Q q 1 0 0 1 739.0117 155.9522 cm 0 0 m 0 15.008 l S Q q 1 0 0 1 52.4883 155.4522 cm 0 0 m 226.799 0 l S Q q 1 0 0 1 52.9883 117.9439 cm 0 0 m 0 37.008 l S Q q 1 0 0 1 279.2877 155.4522 cm 0 0 m 362.736 0 l S Q q 1 0 0 1 279.2877 117.9439 cm 0 0 m 0 37.008 l S Q q 1 0 0 1 642.0237 155.4522 cm 0 0 m 97.488 0 l S Q q 1 0 0 1 642.0237 117.9439 cm 0 0 m 0 37.008 l S Q q 1 0 0 1 739.0117 117.9439 cm 0 0 m 0 37.008 l S Q q 1 0 0 1 52.4883 117.4439 cm 0 0 m 226.799 0 l S Q q 1 0 0 1 52.9883 77.9356 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 279.2877 117.4439 cm 0 0 m 362.736 0 l S Q q 1 0 0 1 279.2877 77.9356 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 642.0237 117.4439 cm 0 0 m 97.488 0 l S Q q 1 0 0 1 642.0237 77.9356 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 739.0117 77.9356 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 52.4883 77.4356 cm 0 0 m 226.799 0 l S Q q 1 0 0 1 279.2877 77.4356 cm 0 0 m 362.736 0 l S Q q 1 0 0 1 642.0237 77.4356 cm 0 0 m 97.488 0 l S Q 0.75 w /GS1 gs q 1 0 0 1 56.9883 158.2866 cm 0 0 m 169.329 0 l S Q /Span <>BDC BT 0 0 0 scn 11 0 0 11 56.9883 159.4522 Tm (Useful in Certain Circumstances)Tj ET EMC /Span <>BDC BT 11 0 0 11 56.9883 143.4439 Tm (Lenvatinib)Tj ET EMC /Span <>BDC BT 9 0 0 9 111.9937 147.4439 Tm (6)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 10 0 0 10 56.9883 132.4439 Tm (\(if not tolerating or no response to recommended )Tj ET EMC /Span <>BDC BT 10 0 0 10 56.9883 121.4439 Tm (agents in patients without curative option\))Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 283.2877 132.4439 Tm (24 mg PO)Tj ET EMC /Span <>BDC BT 11 0 0 11 646.0237 132.4439 Tm (Daily)Tj ET EMC /Span <>BDC BT 11 0 0 11 56.9883 98.9356 Tm (Pembrolizumab)Tj ET EMC /Span <>BDC BT 9 0 0 9 138.8922 102.9356 Tm (7)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 10 0 0 10 56.9883 87.9356 Tm <000b0037003000250010002b0003003e00950014001300030050005800570012003000450040000c>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 283.2877 105.4356 Tm (200mg IV)Tj ET EMC /Span <>BDC BT 11 0 0 11 283.2877 93.4356 Tm (or)Tj ET EMC /Span <>BDC BT 11 0 0 11 283.2877 81.4356 Tm (400mg IV)Tj ET EMC /Span <>BDC BT 11 0 0 11 646.0237 105.4356 Tm (Every 3 weeks)Tj ET EMC /Span <>BDC BT 11 0 0 11 646.0237 81.4356 Tm (Every 6 weeks)Tj ET EMC 0 0.397 0.645 SCN /GS2 gs q 1 0 0 1 709.143 57.2133 cm 0 0 m 59.313 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 709.143 58.3789 Tm (References)Tj ET EMC endstream endobj 536 0 obj 18212 endobj %% Contents for page 51 %% Original object ID: 103 0 537 0 obj << /Length 538 0 R >> stream Q q BT /Xi49 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 538 0 obj 245 endobj %% Original object ID: 446 0 539 0 obj [ 2569 0 R 2570 0 R 2571 0 R ] endobj %% Contents for page 52 %% Original object ID: 104 0 540 0 obj << /Length 541 0 R >> stream q endstream endobj 541 0 obj 2 endobj %% Contents for page 52 %% Original object ID: 447 0 542 0 obj << /Length 543 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm [(Thyroid Carcinoma \226 )37.5 (Anaplastic Carcinoma)]TJ ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs 8 0 0 8 23.044 497.9997 Tm (1)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 28.804 494.9997 Tm [(Adapted with permission fro)-0.7 (m Mary )55.4 (Ann Liebert, Inc., Smallridge RC, et al. )54.6 (American )17.6 (Thyroid )54.9 (Association guidelines for management of patients with anaplastic thyroid ) ]TJ ET EMC /Span <>BDC BT -0.018 Tw 10 0 0 10 28.804 483.9997 Tm [(cancer)54.7 (. Thyroid )-18.3 (2012;22:1)73.5 (121. )]TJ ET EMC /Span <>BDC BT 0 Tw 8 0 0 8 23.044 475.9997 Tm (2)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 28.804 472.9997 Tm [(Subbia)-0.8 (h V)91.9 (, et al. Dabrafenib)-0.9 ( and trametinib treatment in p)-0.8 (atients with locally advanced or metastatic BRAF V600-mutant anaplastic thyroid cancer) 52 (. J Clin Oncol )]TJ ET EMC /Span <>BDC BT 10 0 0 10 28.804 461.9997 Tm (2018;36\(1\):7-13.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.044 453.9997 Tm (3)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 28.804 450.9997 Tm [(Drilon )54.5 (A, et al. Ef)18.2 (ficacy of larotrectinib in )17.6 (TRK fusion-posit)-0.6 (ive cancers in adults and children. N Engl J Med 2018;378\(8\):731-739.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.044 442.9997 Tm (4)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 28.804 439.9997 Tm [(Doebe)-0.8 (le RC, et al. Entrectinib in patients with advanced o)-1.3 (r metastatic NTRK fusion)]TJ /Span<>> BDC (-)Tj EMC (positive solid tumours: integrated analysis of three phase 1)Tj /Span<>> BDC (-)Tj EMC (2 trials. Lancet Oncol )Tj ET EMC /Span <>BDC BT 10 0 0 10 28.804 428.9997 Tm (2020;21:271)Tj /Span<>> BDC (-)Tj EMC (282. )Tj ET EMC /Span <>BDC BT 8 0 0 8 23.044 420.9997 Tm (5)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 28.804 417.9997 Tm [(Wirth L, et al. Registrational)-1.1 ( results of LIBRETT)18.2 (O)]TJ /Span<>> BDC (-)Tj EMC (001: a phase 1/2 trial of selpercatinib \(LOXO)Tj /Span<>> BDC (-)Tj EMC (292\) in patients with RET)Tj /Span<>> BDC 53.283 0 Td (-)Tj EMC (altered thyroid cancers. Presented at the )Tj ET EMC /Span <>BDC BT 10 0 0 10 28.804 406.9997 Tm (Annual Meeting of the European Society for Medical Oncology in Barcelona, Spain; September 27) Tj /Span<>> BDC (-)Tj EMC (October 1, 2019. Oral presentation. )Tj ET EMC /Span <>BDC BT 8 0 0 8 23.044 398.9997 Tm (6)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 28.804 395.9997 Tm [(T)111 (ahara)-0.6 ( M, et )0.5 (al. Lenvatinib for anaplastic thyroid cancer)53.8 (. Front Oncol 2017;7:25.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.044 387.9997 Tm (7)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 28.804 384.9997 Tm [(Marabelle )54.8 (A, et al. )55.4 (Association of tumor mutational burden)-1 ( with outcomes in patients with select advanced solid tumors treated with pembrolizumab in KEYNOTE) ]TJ /Span<>> BDC (-)Tj EMC (158. )Tj ET EMC /Span <>BDC BT 10 0 0 10 28.804 373.9997 Tm [(Presented at the )55 (Annual Meeting of ESMO in Barcelona, Spain; September 30, 2019.)]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 724.3486 35.544 Tm [(ANAP)17.5 (-)17.4 (A)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 734.0595 23.544 Tm [(3 )-17.6 (O)-35 (F)-17.4 ( 3)]TJ ET EMC /Span <>BDC BT 0.035 Tc -0.017 Tw 11 0 0 11 295.9172 514.3517 Tm [(SYSTEMIC)17.2 ( )0.6 (THERAPY)35.5 ( )0.6 (REFERENCES)]TJ ET EMC endstream endobj 543 0 obj 6000 endobj %% Contents for page 52 %% Original object ID: 105 0 544 0 obj << /Length 545 0 R >> stream Q q BT /Xi50 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 545 0 obj 245 endobj %% Original object ID: 449 0 546 0 obj [ 2572 0 R 2573 0 R 2574 0 R ] endobj %% Contents for page 53 %% Original object ID: 106 0 547 0 obj << /Length 548 0 R >> stream q endstream endobj 548 0 obj 2 endobj %% Contents for page 53 %% Original object ID: 450 0 549 0 obj << /Length 550 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma)Tj ET EMC /Artifact <>BDC BT /TT1 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 0.035 Tc -0.017 Tw 11 0 0 11 191.1787 514.3517 Tm [(PRINCIPLES)17.5 ( )0.6 (OF)17.6 ( )0.6 (THYROID)17.3 (-)17.4 (STIMULA)73.9 (TING)17.6 ( )0.6 (HORMONE)17.4 ( )18.2 (\()17.4 (TSH)17.3 (\))34.9 ( )0.6 (SUPPRESSION)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 494.2717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 494.2717 Tm (Because TSH is a trophic hormone that can stimulate the growth of cells derived from thyroid follicular epithelium, the use of levothyroxine ) Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 482.2717 Tm [(to maintain low TSH levels is considered optimal in treatment of patients with papillary) 77.9 (, follicular)56 (, or Hürthle cell carcinoma. However)55.5 (, data )]TJ ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.744 470.2717 Tm <0044005500480003004f00440046004e004c0051004a00030057005200030053004800550050004c005700030053005500480046004c0056004800030056005300480046004c00bf004600440057004c0052005100030052004900030057004b004800030044005300530055005200530055004c0044005700480003005600480055005800500003004f004800590048004f0056000300520049000300370036002b001100030003>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 458.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 458.2717 Tm (In general, patients with known structural residual carcinoma or at high risk for recurrence should have TSH levels maintained below 0.1 ) Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 446.2717 Tm (mU/L, whereas disease-free patients at low risk for recurrence should have TSH levels maintained either slightly below or slightly above the) Tj ET EMC /Span <>BDC BT 11 0 0 11 768.445 446.2717 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 434.2717 Tm (lower limit of the reference range. )Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 422.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 422.2717 Tm (For low-risk patients with biochemical evidence but no structural evidence of disease \(eg, Tg positive, but imaging negative\), maintain TSH ) Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 410.2717 Tm (levels at 0.1\2260.5 mU/L. )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 386.2717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 386.2717 Tm (Patients who remain disease free for several years can probably have their TSH levels maintained within the reference range \(0.5\2262 mU/L\). ) Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 374.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 374.2717 Tm (Given the potential toxicities associated with TSH-suppressive doses of levothyroxine\227including cardiac tachyarrhythmias \(especially in ) Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 362.2717 Tm (the elderly\) and bone demineralization \(particularly in post-menopausal women\) as well as frank symptoms of thyrotoxicosis\227the risks ) Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 37.944 350.2717 Tm <0044005100470003004500480051004800bf00570056000300520049000300370036002b>Tj /Span<>> BDC <0010>Tj EMC <00560058005300530055004800560056004c0059004800030057004b0048005500440053005c00030050005800560057000300450048000300450044004f0044005100460048004700030049005200550003004800440046004b0003004c00510047004c0059004c004700580044004f0003005300440057004c004800510057001100030003>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 338.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 338.2717 Tm (Patients whose TSH levels are chronically suppressed should be counseled to ensure adequate daily intake of calcium \(1200 mg/day\) and ) Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 326.2717 Tm (vitamin D \(1000 units/day\).)Tj ET EMC /Span <>BDC BT 0.035 Tc -0.035 Tw 11 0 0 11 725.5732 23.544 Tm [(THYR)17.3 (-)17.4 (A)]TJ ET EMC endstream endobj 550 0 obj 6083 endobj %% Contents for page 53 %% Original object ID: 107 0 551 0 obj << /Length 552 0 R >> stream Q q BT /Xi51 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. 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NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 0.032 Tc -0.032 Tw 11 0 0 11 725.3583 23.544 Tm [(T)0.5 (HYR)17.7 (-)18 (B)]TJ ET EMC /Span <>BDC BT 0.035 Tc -0.017 Tw 11 0 0 11 155.2224 514.3517 Tm [(PRINCIPLES)17.5 ( )0.6 (OF)17.6 ( )0.6 (KINASE)17.4 ( )0.6 (INHIBIT)18.1 (OR)17.2 ( )0.6 (THERAPY)35.5 ( )0.6 (IN)17.3 ( )37.7 (ADV)74.1 (ANCED)17.2 ( )0.6 (THYROID)17.2 ( )0.6 (CARCINOMA)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 9 0 0 9 623.9631 518.3517 Tm (1-7)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.66 494.2717 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.5672 494.2717 Tm <003200550044004f0003004e004c00510044005600480003004c0051004b004c0045004c005700520055005600030047004800500052005100560057005500440057004800030046004f004c0051004c00460044004f004f005c00030056004c004a0051004c00bf00460044005100570003004400460057004c0059004c0057005c0003004c00510003005500440051004700520050004c005d00480047000f00030053004f00440046004800450052>Tj /Span<>> BDC <0010>Tj EMC <004600520051005700550052004f004f0048004700030046004f004c0051004c00460044004f000300570055004c0044004f00560003004c00510003004f005200460044004f004f005c00030055004800460058005500550048005100570003>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.86 482.2717 Tm <0058005100550048005600480046005700440045004f00480003004400510047000300500048005700440056005700440057004c004600030050004800470058004f004f00440055005c00030057004b005c00550052004c004700030046004400510046004800550003000b003000370026000c00030044005100470003004c00510003005500440047004c0052004c00520047004c00510048>Tj /Span<>> BDC <0010>Tj EMC <005500480049005500440046005700520055005c00030047004c108700480055004800510057004c004400570048004700030057004b005c00550052004c004700030046004400510046004800550003000b002700370026000c0011>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 23.66 458.2717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.5672 458.2717 Tm (When considering kinase inhibitor therapy for individual patients, several factors should be considered. ) Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.26 446.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.26 446.2717 Tm ( Kinase inhibitor therapy can be associated with improved progression-free survival, but is not curative.) Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.26 434.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 38.26 434.2717 Tm <0003002e004c00510044005600480003004c0051004b004c0045004c00570052005500030057004b0048005500440053005c0003004c005600030048005b00530048004600570048004700030057005200030046004400580056004800030056004c00470048000300481087004800460057005600030057004b00440057000300500044005c0003004b0044005900480003004400030056004c004a0051004c00bf00460044005100570003004810870048004600570003005200510003005400580044004f004c0057005c0003005200490003004f004c004900480011>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.26 422.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.26 422.2717 Tm ( The natural history of MTC and DTC is quite variable with rates of disease progression ranging from a few months to many years. ) Tj ET EMC /Span <>BDC BT 11 0 0 11 23.66 398.2717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.5672 398.2717 Tm (The pace of disease progression should be factored into treatment decisions. Patients with very indolent disease who are asymptomatic ) Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.86 386.2717 Tm [<00500044005c000300510052005700030045004800030044005300530055005200530055004c00440057004800030049005200550003004e004c00510044005600480003004c0051004b004c0045004c00570052005500030057004b0048005500440053005c>75.7 <000f00030053004400550057004c00460058004f00440055004f005c0003004c004900030057004b004800030056004c00470048000300481087004800460057005600030052004900030057005500480044005700500048005100570003005a004c004f004f00030044004700590048005500560048004f005c00030044108700480046005700030057004b00480003005300440057004c00480051005700b6>38.8 <00560003005400580044004f004c0057005c0003>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 736.9386 386.2717 Tm ( )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.86 374.2717 Tm <005200490003004f004c00490048000f0003005a004b004800550048004400560003005300440057004c00480051005700560003005a004c0057004b000300500052005500480003005500440053004c0047004f005c0003005300550052004a0055004800560056004c0059004800030047004c00560048004400560048000300500044005c0003004500480051004800bf0057000300490055005200500003004e004c00510044005600480003004c0051004b004c0045004c00570052005500030057004b0048005500440053005c>Tj 49.607 0 Td <000f000300480059004800510003004c004900030057004b0048005c0003004b0044005900480003004700550058004a>Tj /Span<>> BDC <0010>Tj EMC <004c0051004700580046004800470003>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.86 362.2717 Tm <0056004c0047004800030048108700480046005700560011>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 23.66 338.2717 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.5672 338.2717 Tm <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>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.86 326.2717 Tm <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>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 30.86 314.2717 Tm (may be required, including dose holds and dose reductions.)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.66 290.2717 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.5672 290.2717 Tm <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>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 30.86 278.2717 Tm (trial participation. In addition, the presence of some mutations may have prognostic importance.) Tj ET EMC /Span <>BDC BT /TT1 1 Tf 8 0 0 8 23.7612 188.456 Tm (1)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 185.456 Tm [(W)18.2 (ells SA)55.2 ( Jr)55.3 (, Robinson BG, Gagel RF)110.5 (, et al. V)74.7 (andetanib in)-1.2 ( patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 756.7576 185.456 Tm ( )Tj ET EMC /Span <>BDC BT 10 0 0 10 29.5212 174.456 Tm (trial. J Clin Oncol 2012;30:134-141.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 166.456 Tm (2)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 163.456 Tm [(Brose MS, Nutting CM, Jarzab B, et al. Sorafenib in radio)-0.9 (active iodine-refractory)73.1 (, locally advanced or metastatic dif)16.9 (ferentiated thyroid cancer: a randomized, )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 152.456 Tm (double-blind, phase 3 trial. Lancet 2014;384\(9940\):319-328.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 144.456 Tm (3)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 141.456 Tm [(Elisei R, Schlumberger MJ, Müller SP)128.4 (, et al. Cabozantinib)-0.8 ( in progressive medullary thyroid cancer)52.7 (. J Clin Oncol 2013;31:3639-3646.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 133.456 Tm (4)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 130.456 Tm [(Burtness B, )55.7 (Anadkat M, Basti S, et al. NCCN )18.3 (T)111 (ask Force Report: Management of dermatologic and other toxicities associated with EGFR inhibition in patients with ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 119.456 Tm [(cancer)54.7 (. J Natl Compr Canc Netw 2009;7 Suppl 1:S5-S21.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 111.456 Tm (5)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 108.456 Tm [(Brose MS, Fr)0.5 (enette CT)110.9 (, Keefe SM, Stein SM. Management of sorafenib-related adverse events: a clinician\222) 15.6 (s perspective. Semin Oncol 2014;41 Suppl 2:S1-S16.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.7612 100.456 Tm (6)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 97.456 Tm [(Carhill)-1 ( )55.4 (AA, Cabanillas ME, Jimenez C, et al. )18.1 (The noninve)-0.9 (stigational use of tyrosine kinase inhibitors in thyroid cancer: establishing a standard for patient safety and ) ]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.5212 86.456 Tm (monitoring. J Clin Endocrinol Metab 2013;98:31-42.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.7612 78.456 Tm (7)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.5212 75.456 Tm [(Schlumberge)-1.1 (r M, )18.4 (T)111 (ahara M, Wirth LJ, et al. Lenvatinib ve)-0.7 (rsus placebo in radioiodine-refractory thyroid cancer)52 (. N Engl J Med 2015;372\(7\):621-30.)]TJ ET EMC endstream endobj 557 0 obj 12954 endobj %% Contents for page 54 %% Original object ID: 109 0 558 0 obj << /Length 559 0 R >> stream Q q BT /Xi52 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 559 0 obj 245 endobj %% Original object ID: 455 0 560 0 obj [ 2578 0 R 2579 0 R 2580 0 R 2581 0 R 2582 0 R 2583 0 R 2584 0 R ] endobj %% Contents for page 55 %% Original object ID: 110 0 561 0 obj << /Length 562 0 R >> stream q endstream endobj 562 0 obj 2 endobj %% Contents for page 55 %% Original object ID: 456 0 563 0 obj << /Length 564 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma)Tj ET EMC /Artifact <>BDC BT /TT1 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 725.165 35.544 Tm [(THYR)17.3 (-)17.4 (C)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 734.0595 23.544 Tm [(1 )-17.6 (O)-35 (F)-17.4 ( 5)]TJ ET EMC /Span <>BDC BT 0.035 Tc -0.017 Tw 11 0 0 11 212.2253 514.3517 Tm [(PRINCIPLES)17.5 ( )0.6 (OF)17.6 ( )0.6 (RADIA)73.9 (TION)17.3 ( )37.7 (AND)17.2 ( )0.6 (RADIOACTIVE)17.5 ( )0.6 (IODINE)17.4 ( )0.6 (THERAPY)]TJ ET EMC /Span <>BDC BT -0.054 Tw 11 0 0 11 313.7927 502.3517 Tm (IODINE)Tj /Span<>> BDC 3.638 0 Td (-)Tj EMC 0.333 0 Td [(1)34.8 (3)34.9 (1)34.9 ( )0.7 (ADMINISTRA)73.9 (TION)]TJ ET EMC 0 0 0 SCN q 1 0 0 1 23.544 504.1062 cm 0 0 m 96.599 0 l S Q 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 77.1771 258.1062 cm 0 0 m 54.393 0 l S Q q 1 0 0 1 157.2386 258.1062 cm 0 0 m 117.734 0 l S Q /Span <>BDC BT /GS0 gs 0 Tc 0 Tw 11 0 0 11 23.544 505.2717 Tm (General Principles)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 23.544 488.7717 Tm <003300440057004c0048005100570056000300500044005c0003004500480003005a004c0057004b004700550044005a00510003004900550052005000030057004b005c00550052004c00470003004b00520055005000520051004800030057005200030044004f004f0052005a00030044004700480054005800440057004800030048004f0048005900440057004c00520051000300520049000300370036002b0003000b0021001600130003005000380012004f000c>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 9 0 0 9 523.2061 492.7717 Tm (1)Tj ET EMC /Span <>BDC BT 11 0 0 11 528.2115 488.7717 Tm (, or prepared using 2 consecutive daily )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 476.7717 Tm (intramuscular injections of thyrotropin alfa for initial iodine)Tj /Span<>> BDC (-)Tj EMC (131 ablation of post)Tj /Span<>> BDC (-)Tj EMC (surgical gland remnant and/or treatment of locoregional )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 464.7717 Tm (residual or recurrent disease. )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 448.2717 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 448.2717 Tm <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>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 30.744 436.2717 Tm (hormone replacement in the initial postoperative setting. Because of the half) Tj /Span<>> BDC (-)Tj EMC (life of endogenous thyroid hormone, 4\2266 weeks are required for )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 424.2717 Tm [(clearance following total thyroidectomy)75.3 (. Consequently)74.7 (, if no thyroid hormone is given following total thyroidectomy in an euthyroid patient, ) ]TJ ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.744 412.2717 Tm <0048005100470052004a00480051005200580056000300370036002b0003004f004800590048004f005600030056004b00520058004f004700030045004800030056005810880046004c004800510057004f005c00030048004f0048005900440057004800470003000b002100160013000c0003004c00510003001600b100190003005a00480048004e005600110003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 23.544 395.7717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 395.7717 Tm (Thyroid hormone withdrawal is preferred for most patients with distant metastatic disease based on the likelihood of augmentation of the ) Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 383.7717 Tm (delivered radiation dose. While thyrotropin alfa is not FDA)Tj /Span<>> BDC (-)Tj EMC (approved for treatment of distant metastases, it has been studied in this setting ) Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 371.7717 Tm (in retrospective cohorts and its use may be considered for patients unable to withdraw from thyroid hormone based on comorbidities and ) Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 359.7717 Tm (other clinical considerations.)Tj ET EMC /Span <>BDC BT 9 0 0 9 182.9501 363.7717 Tm (2,3)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 343.2717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 343.2717 Tm (Regardless of preparation method, an iodine)Tj /Span<>> BDC (-)Tj EMC (restricted diet is recommended for 10\22614 days prior to iodine)Tj /Span<>> BDC (-)Tj EMC [(131 therapy)75.6 (. )37.4 (A)37 ( review of recent )]TJ ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.744 331.2717 Tm <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>Tj 64.906 0 Td <000f0003>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 319.2717 Tm <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>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 30.744 307.2717 Tm (over this period. Most common contrast media for CT requires a 2)Tj /Span<>> BDC (-)Tj EMC (month period between contrast administration and iodine scintigraphy for ) Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.744 295.2717 Tm <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>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 30.744 283.2717 Tm (iodine)Tj /Span<>> BDC (-)Tj EMC (restricted diet. The diet involves a 10)Tj /Span<>> BDC (-)Tj EMC ( to 14)Tj /Span<>> BDC (-)Tj EMC (day reduction in intake of iodized salt, seafood, and dairy products with the intention of ) Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.744 271.2717 Tm <005200530057004c0050004c005d004c0051004a00030057004b004800030056004800510056004c0057004c0059004c0057005c00030052004900030047004c0044004a0051005200560057004c004600030048005b004400500056000300440051004700030057004b0048000300481088004600440046005c0003005200490003005300520057004800510057004c0044004f00030057004b0048005500440053004c0048005600030057004b00440057000300500044005c000300490052004f004f0052005a>Tj 47.556 0 Td <001100030028005b00460048004f004f0048005100570003005500480056005200580055004600480003004c0051004900520055005000440057004c0052005100030046004400510003004500480003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 30.744 259.2717 Tm (found at )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 77.1771 259.2717 Tm (ThyCa.org)Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 131.5702 259.2717 Tm ( and )Tj ET EMC /Span <>BDC BT 0 0.397 0.645 scn /GS1 gs 11 0 0 11 157.2386 259.2717 Tm [(LIDLifeCommunity)74.5 (.org)]TJ ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 274.973 259.2717 Tm (. )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 242.7717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 242.7717 Tm (Documentation of negative pregnancy test or infertility status is required for female patients of reproductive age prior to administration of ) Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 230.7717 Tm [(radioiodine therapy)74.9 (.)]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.544 214.2717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 214.2717 Tm (Adherence to all local, state, and national regulatory guidelines including signed informed consent and signed written directive from an ) Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.744 202.2717 Tm <004400580057004b00520055004c005d004800470003005800560048005500030056004b00520058004f0047000300450048000300460052005100bf00550050004800470011>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 23.544 185.7717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 185.7717 Tm [(W)18.2 (ritten guidelines for minimizing exposure to others should be provided for patient signature, as per national and state regulatory ) ]TJ ET EMC /Span <>BDC BT 11 0 0 11 30.744 173.7717 Tm (requirements.)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 157.2717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 157.2717 Tm (Pre)Tj /Span<>> BDC (-)Tj EMC (treatment radioiodine imaging may be considered and a post)Tj /Span<>> BDC (-)Tj EMC (treatment iodine)Tj /Span<>> BDC (-)Tj EMC (131 whole body scan should be performed in all cases.)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 140.7717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 140.7717 Tm (Pre)Tj /Span<>> BDC (-)Tj EMC (therapy whole body scans may be obtained using 2\2264 mCi iodine)Tj /Span<>> BDC (-)Tj EMC (123 or 1\2262 mCi iodine)Tj /Span<>> BDC (-)Tj EMC (131. Iodine)Tj /Span<>> BDC (-)Tj EMC (123 avoids stunning and has )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 128.7717 Tm (favorable imaging characteristics. Low activity \(1\2263 mCi\) iodine)Tj /Span<>> BDC (-)Tj EMC (131 minimizes stunning and has a longer physical half)Tj /Span<>> BDC (-)Tj EMC (life that will permit )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 116.7717 Tm (delayed imaging to improve lesion detection while permitting dosimetry in cases where dose maximization is considered. If iodine) Tj /Span<>> BDC (-)Tj EMC (131 is )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.744 104.7717 Tm <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>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 23.544 88.2717 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 88.2717 Tm [<003300440057004c00480051005700560003005a004c0057004b0003>0.9 <004b004c004a004b0003>1.1 <000b00210014001300130013>-0.6 <0003>0.5 <00500026004c000c00030046005800500058004f00440057004c005900480003004f004c004900480057004c005000480003004400470050004c0051004c0056005700480055004800470003004400460057004c0059004c0057004c0048005600030056004b00520058004f00470003>1.1 <004500480003>0.5 <005000520051004c005700520055004800470003>0.7 <0049005200550003>0.5 <0050005c0048004f005200560058005300530055004800560056004c005200510003>0.5 <0044005100470003>0.6 <005300520057004800510057004c0044004f0003>0.9 <004f00520051004a001000570048005500500003>]TJ ET EMC /Span <>BDC BT 11 0 0 11 30.744 76.2717 Tm <00570052005b004c0046004c0057004c00480056000f000300440051004700030044004f0057004b00520058004a004b0003005500440055004800030057004b004c005600030056004b00520058004f004700030045004800030046005200510056004c004700480055004800470003004c00510003004400030055004c0056004e0010004500480051004800bf00570003004400510044004f005c0056004c005600030049005200550003005800560048000300520049000300350024002c000f0003004400560003005a004c0057004b000300440051005c000300520057004b0048005500030057004b0048005500440053005c>Tj 57.271 0 Td <0011>Tj ET EMC /GS1 gs q 1 0 0 1 707.436 66.2133 cm 0 0 m 54.377 0 l S Q q 1 0 0 1 707.436 54.2133 cm 0 0 m 59.313 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn /TT0 1 Tf 11 0 0 11 707.436 67.3789 Tm (Continued)Tj ET EMC /Span <>BDC BT 11 0 0 11 707.436 55.3789 Tm (References)Tj ET EMC endstream endobj 564 0 obj 16146 endobj %% Contents for page 55 %% Original object ID: 111 0 565 0 obj << /Length 566 0 R >> stream Q q BT /Xi53 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 566 0 obj 245 endobj %% Original object ID: 458 0 567 0 obj [ 2585 0 R 2586 0 R 2587 0 R 2588 0 R 2589 0 R ] endobj %% Contents for page 56 %% Original object ID: 112 0 568 0 obj << /Length 569 0 R >> stream q endstream endobj 569 0 obj 2 endobj %% Contents for page 56 %% Original object ID: 459 0 570 0 obj << /Length 571 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma)Tj ET EMC /Artifact <>BDC BT /TT1 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 725.165 35.544 Tm [(THYR)17.3 (-)17.4 (C)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 734.0595 23.544 Tm [(2 )-17.6 (O)-35 (F)-17.4 ( 5)]TJ ET EMC /Span <>BDC BT 0.035 Tc -0.017 Tw 11 0 0 11 212.2253 514.3517 Tm [(PRINCIPLES)17.5 ( )0.6 (OF)17.6 ( )0.6 (RADIA)73.9 (TION)17.3 ( )37.7 (AND)17.2 ( )0.6 (RADIOACTIVE)17.5 ( )0.6 (IODINE)17.4 ( )0.6 (THERAPY)]TJ ET EMC /Span <>BDC BT -0.054 Tw 11 0 0 11 313.7927 502.3517 Tm (IODINE)Tj /Span<>> BDC 3.638 0 Td (-)Tj EMC 0.333 0 Td [(1)34.8 (3)34.9 (1)34.9 ( )0.7 (ADMINISTRA)73.9 (TION)]TJ ET EMC 0 0 0 SCN q 1 0 0 1 23.544 487.1062 cm 0 0 m 112.675 0 l S Q q 1 0 0 1 23.544 149.6062 cm 0 0 m 120.447 0 l S Q /Span <>BDC BT 0 Tc -0.037 Tw 11 0 0 11 23.544 488.2717 Tm (Administered Activity)Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 23.544 471.7717 Tm (See special circumstances below for pediatric dose adjustment.)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 459.7717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 459.7717 Tm (Remnant ablation:)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 447.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 447.7717 Tm (30\22650 mCi )Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 46.9796 435.7717 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 41.544 435.7717 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 50.0357 435.7717 Tm (If RAI ablation is used in T1b/T2 \(1\2264 cm\), clinical N0 disease, in ) Tj ET EMC /Span <>BDC BT 11 0 0 11 50.184 423.7717 Tm [(the absence of other adverse pathologic, laboratory)75 (, or imaging )]TJ ET EMC /Span <>BDC BT 11 0 0 11 50.184 411.7717 Tm (features, 30 mCi of iodine)Tj /Span<>> BDC (-)Tj EMC (131 is recommended \(category 1\) )Tj ET EMC /Span <>BDC BT 11 0 0 11 50.184 399.7717 Tm (following either thyrotropin alfa stimulation or thyroid hormone )Tj ET EMC /Span <>BDC BT 11 0 0 11 50.184 387.7717 Tm (withdrawal. This dose of 30 mCi may also be considered )Tj ET EMC /Span <>BDC BT 11 0 0 11 50.184 375.7717 Tm (\(category 2B\) for patients with T1b/T2 \(1\2264 cm\) with small )Tj ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 50.184 363.7717 Tm <00590052004f005800500048000300310014004400030047004c005600480044005600480003000b00490048005a0048005500030057004b00440051000300180003004f005c00500053004b00030051005200470048000300500048005700440056005700440056004800560003001f00150003>Tj ET EMC /Span <>BDC BT 11 0 0 11 50.184 351.7717 Tm <005000500003004c005100030047004c004400500048005700480055000c000300440051004700030049005200550003005300440057004c00480051005700560003005a004c0057004b000300530055004c005000440055005c00030057005800500052005500560003001f0017000300460050000f0003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 50.184 339.7717 Tm (clinical M0 with minor extrathyroidal extension.)Tj ET EMC /Span <>BDC BT 9 0 0 9 297.7431 343.7717 Tm (4,5)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 327.7717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 327.7717 Tm (Adjuvant therapy:)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 315.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 315.7717 Tm (50\226100 mCi )Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 46.9796 303.7717 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 41.544 303.7717 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 50.0357 303.7717 Tm (For higher likelihood of residual disease based on operative )Tj ET EMC /Span <>BDC BT 11 0 0 11 50.184 291.7717 Tm (pathology or pretherapy radioiodine scan)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 279.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 279.7717 Tm (100\226200 mCi)Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 46.9796 267.7717 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 41.544 267.7717 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 50.0357 267.7717 Tm (For proven unresectable metastatic disease based on pathology )Tj ET EMC /Span <>BDC BT 11 0 0 11 50.184 255.7717 Tm (or pretherapy radioiodine scan)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 243.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 243.7717 Tm (Dosimetry can be used to determine maximal dose at high)Tj /Span<>> BDC (-)Tj EMC (volume )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 231.7717 Tm (centers for documented nonresectable, large)Tj /Span<>> BDC (-)Tj EMC (volume, iodine)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 37.944 219.7717 Tm [(concentrating, residual, or recurrent disease. Generally)74.6 (, the )]TJ ET EMC /Span <>BDC BT 11 0 0 11 37.944 207.7717 Tm (maximum 48)Tj /Span<>> BDC (-)Tj EMC (hour whole)Tj /Span<>> BDC (-)Tj EMC (body dose should not exceed ~80 mCi to )Tj ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 37.944 195.7717 Tm <004400590052004c0047000300530058004f00500052005100440055005c000300bf0045005500520056004c00560003004c005100030057004b00480003004600440056004800030052004900030047004c10870058005600480003004f00580051004a00030050004800570044005600570044005600480056000f0003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 37.944 183.7717 Tm (and the bone marrow retention maximum should not exceed ~120 )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 171.7717 Tm (mCi at 48 hours.)Tj ET EMC /Span <>BDC BT 9 0 0 9 123.5216 175.7717 Tm (1)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 150.7717 Tm (Special Circumstances)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 138.7717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 138.7717 Tm (Pediatric patients:)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 126.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 126.7717 Tm (Chest imaging using non)Tj /Span<>> BDC (-)Tj EMC (contrast CT prior to treatment to assess )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 114.7717 Tm (for lung metastases )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 27.144 102.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 102.7717 Tm [(W)18.2 (eight based dose adjustment for pediatric patients assuming )]TJ ET EMC /Span <>BDC BT 11 0 0 11 37.944 90.7717 Tm (routine dosing for 70 kg adult \(ie, a 150 mCi dose for a 70 kg adult )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 78.7717 Tm (would translate to 2.15 mCi/kg for the pediatric patient\))Tj ET EMC /Span <>BDC BT 9 0 0 9 325.2116 82.7717 Tm (6)Tj ET EMC q 1 0 0 1 402 487.1062 cm 0 0 m 120.447 0 l S Q /Span <>BDC BT 11 0 0 11 402 488.2717 Tm (Special Circumstances)Tj ET EMC /Span <>BDC BT 11 0 0 11 402 471.7717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 471.7717 Tm (RAI after imaging study or procedure using iodine contrast agent:)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 405.6 459.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 416.6 459.7717 Tm [<003a>37.3 <0044004c00570003001400b1001500030050005200510057004b005600030057005200030044004f004f0052005a0003004900520055000300490055004800480003004c00520047004c005100480003004f004800590048004f00560003005700520003004700480046005500480044005600480003000b001f0014001300130003>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.4 447.7717 Tm (mcg/24 hours\) and allow for optimal)Tj ET EMC /Span <>BDC BT 0.753 0.02 0.973 scn /GS1 gs 11 0 0 11 604.6461 447.7717 Tm ( )Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 607.7023 447.7717 Tm (RAI)Tj ET EMC /Span <>BDC BT 0.753 0.02 0.973 scn /GS1 gs 11 0 0 11 626.6461 447.7717 Tm ( )Tj ET EMC /Span <>BDC BT 0 0 0 scn /GS0 gs 11 0 0 11 629.7023 447.7717 Tm (uptake)Tj ET EMC /Span <>BDC BT 9 0 0 9 665.1569 451.7717 Tm (7,8)Tj ET EMC /Span <>BDC BT 11 0 0 11 677.6681 447.7717 Tm ( )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 405.6 435.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 416.6 435.7717 Tm <0026005200510056004c0047004800550003005000480044005600580055004800500048005100570003005200490003001500170010004b005200580055000300580055004c005100480003004c00520047004c00510048000300570052000300460052005100bf0055005000030044000300510052005500500044004f0003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.4 423.7717 Tm (free iodine prior to preparing for dosing. )Tj ET EMC /Span <>BDC BT 11 0 0 11 402 411.7717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9073 411.7717 Tm (Breastfeeding patients:)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 405.6 399.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 399.7717 Tm [(W)37.3 (ait 3\2266 months after cessation of lactation or with normalization )]TJ ET EMC /Span <>BDC BT 11 0 0 11 416.4 387.7717 Tm (of serum prolactin levels.)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 405.6 375.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 375.7717 Tm (Complete cessation of breastfeeding after iodine)Tj /Span<>> BDC (-)Tj EMC (123 or iodine)Tj /Span<>> BDC (-)Tj EMC (131 )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 363.7717 Tm (administration for the current infant. There should be no increased )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 351.7717 Tm (risk to mother or infant for breastfeeding with subsequent births )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 339.7717 Tm (assuming no radioiodine is administered around the subsequent )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 327.7717 Tm (birth/breastfeeding period.)Tj ET EMC /Span <>BDC BT 9 0 0 9 555.7477 331.7717 Tm (9)Tj ET EMC /Span <>BDC BT 11 0 0 11 402 315.7717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9073 315.7717 Tm (Decreased GFR/end)Tj /Span<>> BDC (-)Tj EMC (stage renal disease \(ESRD\)/hemodialysis:)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 405.6 303.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 303.7717 Tm (Special consideration to administered dose, and timing with )Tj ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 416.4 291.7717 Tm <005500480056005300480046005700030057005200030047004c0044004f005c0056004c0056000300570052000300500044005b004c0050004c005d004800030057004b0048005500440053004800580057004c0046000300481087004800460057000300440051004700030050004c0051004c0050004c005d00480003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.4 279.7717 Tm (non)Tj /Span<>> BDC (-)Tj EMC (thyroid uptake/exposure)Tj ET EMC /Span <>BDC BT 9 0 0 9 567.9723 283.7717 Tm (10)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 405.6 267.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 267.7717 Tm (Multidisciplinary involvement including close monitoring by )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 255.7717 Tm (radiation safety to coordinate administration, monitoring, and )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 243.7717 Tm (minimization of exposure to others)Tj ET EMC /Span <>BDC BT 11 0 0 11 402 231.7717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9073 231.7717 Tm (Patients desiring pregnancy)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 405.6 219.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 219.7717 Tm [(W)18.2 (omen should be counseled to wait at least 6 months after )]TJ ET EMC /Span <>BDC BT 11 0 0 11 416.4 207.7717 Tm (iodine)Tj /Span<>> BDC (-)Tj EMC (131 therapy to attempt pregnancy to avoid adverse )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 195.7717 Tm (pregnancy outcomes \(such as fetal hypothyroidism, malformation, )Tj ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 416.4 183.7717 Tm <004c00510046005500480044005600480047000300500044004f004c004a0051004400510046005c00030055004c0056004e0003004c005100030057004b004800030046004b004c004f0047000f00030052005500030049004800570044004f0003004700480050004c005600480003003e005a004c0057004b0003004b004c004a004b0003>Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 171.7717 Tm <004700520056004800560040000c000300550048004f0044005700480047000300570052000300350024002c001100030029005200550003005000440051005c0003005300440057004c0048005100570056000300440003004f00520051004a004800550003004c005100570048005500590044004f00030045004800490052005500480003>Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 159.7717 Tm <0044005700570048005000530057004c0051004a0003005300550048004a0051004400510046005c000300500044005c0003004500480003005500480046005200500050004800510047004800470003004c0051000300520055004700480055000300570052000300460052005100bf005500500003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.4 147.7717 Tm (disease)Tj /Span<>> BDC (-)Tj EMC (free status at 6\22612 months post)Tj /Span<>> BDC (-)Tj EMC (RAI. In these cases, )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 135.7717 Tm (earlier pregnancy is inadvisable as it would interfere with disease )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 123.7717 Tm (detection and further management.)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 405.6 111.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 111.7717 Tm (In selective cases when doses are high or other considerations )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 99.7717 Tm (are present, integrating care with reproductive endocrinology/)Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 87.7717 Tm (oncofertility for men and women may be appropriate.)Tj ET EMC 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 707.436 66.2133 cm 0 0 m 54.377 0 l S Q q 1 0 0 1 707.436 54.2133 cm 0 0 m 59.313 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 707.436 67.3789 Tm (Continued)Tj ET EMC /Span <>BDC BT 11 0 0 11 707.436 55.3789 Tm (References)Tj ET EMC endstream endobj 571 0 obj 18459 endobj %% Contents for page 56 %% Original object ID: 113 0 572 0 obj << /Length 573 0 R >> stream Q q BT /Xi54 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 573 0 obj 245 endobj %% Original object ID: 461 0 574 0 obj [ 2590 0 R 2591 0 R 2592 0 R 2593 0 R 2594 0 R ] endobj %% Contents for page 57 %% Original object ID: 114 0 575 0 obj << /Length 576 0 R >> stream q endstream endobj 576 0 obj 2 endobj %% Contents for page 57 %% Original object ID: 462 0 577 0 obj << /Length 578 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma)Tj ET EMC /Artifact <>BDC BT /TT1 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 725.165 35.544 Tm [(THYR)17.3 (-)17.4 (C)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 734.0595 23.544 Tm [(3 )-17.6 (O)-35 (F)-17.4 ( 5)]TJ ET EMC /Span <>BDC BT 0.035 Tc -0.017 Tw 11 0 0 11 212.2253 514.3517 Tm [(PRINCIPLES)17.5 ( )0.6 (OF)17.6 ( )0.6 (RADIA)73.9 (TION)17.3 ( )37.7 (AND)17.2 ( )0.6 (RADIOACTIVE)17.5 ( )0.6 (IODINE)17.4 ( )0.6 (THERAPY)]TJ ET EMC /Span <>BDC BT 11 0 0 11 263.197 502.3517 Tm [(EXTERNAL)35.7 ( )0.5 (BEAM)17.4 ( )0.6 (RADIA)73.9 (TION)17.2 ( )0.6 (THERAPY)35.5 ( )18.2 (\()17.4 (EBRT)17.6 (\))]TJ ET EMC 0 0 0 SCN q 1 0 0 1 23.544 493.1062 cm 0 0 m 96.599 0 l S Q q 1 0 0 1 23.544 292.1062 cm 0 0 m 100.66 0 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 494.2717 Tm (General Principles)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 477.7717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 477.7717 Tm (The decision to treat and timing of treatment with EBRT for thyroid carcinoma is best made by a multidisciplinary team that must include ) Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 465.7717 Tm (a radiation oncologist. Evaluation by a radiation oncologist early in the course of treatment for thyroid carcinoma is preferred. The ) Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.744 453.7717 Tm <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>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 441.7717 Tm [<005a004b004800510003005700520003004c0051004600520055005300520055004400570048000300280025003500370003004c0051005700520003004400510003004c00510047004c0059004c004700580044004f0003005300440057004c00480051005700b6>40.5 <0056000300570055004800440057005000480051005700030053004f004400510011>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 23.544 429.7717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 429.7717 Tm (Consider dental, speech and swallowing, and nutrition evaluation and treatment prior to radiation therapy \(RT\) to determine if pre) Tj /Span<>> BDC (-)Tj EMC (treatment )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 417.7717 Tm (optimization of dental and oral health or gastrostomy placement is appropriate.) Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 405.7717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 405.7717 Tm (Pre)Tj /Span<>> BDC (-)Tj EMC (treatment imaging including contrast)Tj /Span<>> BDC (-)Tj EMC [(enhanced CT or MRI, iodine total body scan/SPECT)114.1 (, and FDG)]TJ /Span<>> BDC (-)Tj EMC [( or DOT)75.6 (A)74 (T)74.4 (A)74 (TE)]TJ /Span<>> BDC (-)Tj EMC (PET can be used to )Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 393.7717 Tm (guide radiotherapy volumes.)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 381.7717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 381.7717 Tm [(For patients receiving both RAI and EBRT)112.2 (, the sequence of these therapies should be determined individually for each clinical circumstance.) ]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.544 369.7717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 369.7717 Tm (Conformal radiotherapy techniques including intensity)Tj /Span<>> BDC (-)Tj EMC (modulated RT \(IMRT\) with simultaneous integrated boost \(SIB\) and image guidance ) Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.744 357.7717 Tm <004400550048000300560057005500520051004a004f005c00030048005100460052005800550044004a004800470003004c005100030057004b0048000300440047004d0058005900440051005700120047004800bf0051004c0057004c0059004800030056004800570057004c0051004a0003004a004c00590048005100030057004b00480003005300520057004800510057004c0044004f000300490052005500030055004800470058004600480047000300570052005b004c0046004c0057005c>Tj 45.822 0 Td <0011>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 23.544 345.7717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 345.7717 Tm (For unresected or incompletely resected anaplastic thyroid carcinoma, RT should be started as quickly as possible. Consider a rapid start ) Tj ET EMC /Span <>BDC BT 11 0 0 11 30.744 333.7717 Tm (with 3D RT plan converted to a more conformal RT approach when possible.) Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 321.7717 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 321.7717 Tm [<0029005200550003003500130003005200550003003500140003005500480056004800460057004c005200510003005200490003>37.5 <0024>74 <00370026000f000300440047004d005800590044005100570003005500440047004c00520057004b0048005500440053005c00030052005500030046004b004800500052005500440047004c00440057004c0052005100030056004b00520058004f00470003005600570044005500570003004400560003005600520052005100030044005600030057004b00480003005300440057004c0048005100570003004c005600030056005810880046004c004800510057004f005c0003005500480046005200590048005500480047000300490055005200500003>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 30.744 309.7717 Tm [(surgery)73.8 (, ideally 2\2263 weeks postoperatively)74.2 (.)]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.544 293.2717 Tm [(T)55.3 (reatment V)73.8 (olumes)]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.544 276.7717 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 30.4512 276.7717 Tm <0027004c108700480055004800510057004c0044005700480047000f00030030004800470058004f004f00440055005c00030052005500030033005200520055004f005c00030027004c108700480055004800510057004c00440057004800470003000b00510052005100100044005100440053004f004400560057004c0046000c00030037004b005c00550052004c00470003002600440051004600480055000300b1000300440047004d00580059004400510057000300520055000300550048004600580055005500480051005700120053004800550056004c00560057004800510057000300350037>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 264.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 264.7717 Tm (Little evidence exists for appropriate treatment volumes for thyroid carcinoma. Common practice in published institutional and multi) Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 37.944 252.7717 Tm (institutional reports are described.)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 240.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 38.144 240.7717 Tm <002a00550052005600560003005500480056004c004700580044004f00030047004c005600480044005600480003004c005100030057004b004800030057004b005c00550052004c00470003004500480047000300520055000300550048004a004c005200510044004f0003004f005c00500053004b00030051005200470048005600030056004b00520058004f00470003004500480003004c00510046004f00580047004800470003004c0051000300440003004a0055005200560056000300570058005000520055000300590052004f0058005000480003000b002a00370039000c0003000b0044005600030047004800bf005100480047000300520051000300260037>Tj 64.343 0 Td <000f0003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 37.944 228.7717 Tm (MRI, and/or FDG)Tj /Span<>> BDC (-)Tj EMC (PET\).)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 216.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 38.144 216.7717 Tm <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>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 37.944 204.7717 Tm (disease/thyroid tissue\). Regional lymph node levels II\226VI can be included if involved or as elective volumes if not evaluated. Dose levels for ) Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 37.944 192.7717 Tm [<004800440046004b000300440055004800030047004c00560046005800560056004800470003004c0051000300b300270052005600480003004400510047000300290055004400460057004c0052005100440057004c0052005100b4000300450048004f0052005a>38.6 <0011>]TJ ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 180.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 180.7717 Tm [(GTV should be expanded by 0.5\2261.5 cm to CTV)93.6 (.)]TJ ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 168.7717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 168.7717 Tm [(Planning target volume \(PTV\) margins of 0.3\2260.5 cm should be added to CTV) 94.8 (, depending on technique and image guidance used.)]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.544 152.2717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 152.2717 Tm (Anaplastic thyroid carcinoma)Tj ET EMC /Span <>BDC BT 9 0 0 9 184.4942 156.2717 Tm [(1)55 (1)]TJ /Span<>> BDC (-)Tj EMC (14)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 140.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 140.2717 Tm (GTV includes gross primary disease and involved lymph nodes \(determined on contrast) Tj /Span<>> BDC (-)Tj EMC [(enhanced CT)113.3 (, MRI, and/or FDG)]TJ /Span<>> BDC (-)Tj EMC [(PET)112.3 (, assuming )]TJ ET EMC /Span <>BDC BT 11 0 0 11 37.944 128.2717 Tm (obtaining these studies does not delay start of treatment\).)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 116.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 116.2717 Tm (High)Tj /Span<>> BDC (-)Tj EMC [(risk CTV may include involved lymph node regions and postoperative bed in the case of partial or complete debulking surgery) 78.9 (.)]TJ ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 104.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 38.144 104.2717 Tm <0028004f004800460057004c0059004800030051005200470044004f000300550048004a004c005200510056000300500044005c0003004500480003004c00510046004f00580047004800470003004c00510003004f0052005a0010004700520056004800030026003700390003004c004900030048005b005700480051004700480047001000bf0048004f00470003003500370003004c0056000300580056004800470011>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 92.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 92.2717 Tm [(GTV should be expanded by 0.5\2261.5 cm to CTV)93.6 (.)]TJ ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 80.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 80.2717 Tm [(PTV margins of 0.3\2260.5 cm should be added to CTV)93.7 (, depending on technique and image guidance used.)]TJ ET EMC 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 707.436 66.2133 cm 0 0 m 54.377 0 l S Q q 1 0 0 1 707.436 54.2133 cm 0 0 m 59.313 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 707.436 67.3789 Tm (Continued)Tj ET EMC /Span <>BDC BT 11 0 0 11 707.436 55.3789 Tm (References)Tj ET EMC endstream endobj 578 0 obj 14690 endobj %% Contents for page 57 %% Original object ID: 115 0 579 0 obj << /Length 580 0 R >> stream Q q BT /Xi55 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 580 0 obj 245 endobj %% Original object ID: 464 0 581 0 obj [ 2595 0 R 2596 0 R 2597 0 R 2598 0 R ] endobj %% Contents for page 58 %% Original object ID: 116 0 582 0 obj << /Length 583 0 R >> stream q endstream endobj 583 0 obj 2 endobj %% Contents for page 58 %% Original object ID: 465 0 584 0 obj << /Length 585 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma)Tj ET EMC /Artifact <>BDC BT /TT1 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 725.165 35.544 Tm [(THYR)17.3 (-)17.4 (C)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 734.0595 23.544 Tm [(4 )-17.6 (O)-35 (F)-17.4 ( 5)]TJ ET EMC /Span <>BDC BT 0.035 Tc -0.017 Tw 11 0 0 11 212.2253 514.3517 Tm [(PRINCIPLES)17.5 ( )0.6 (OF)17.6 ( )0.6 (RADIA)73.9 (TION)17.3 ( )37.7 (AND)17.2 ( )0.6 (RADIOACTIVE)17.5 ( )0.6 (IODINE)17.4 ( )0.6 (THERAPY)]TJ ET EMC /Span <>BDC BT 11 0 0 11 263.197 502.3517 Tm [(EXTERNAL)35.7 ( )0.5 (BEAM)17.4 ( )0.6 (RADIA)73.9 (TION)17.2 ( )0.6 (THERAPY)35.5 ( )18.2 (\()17.4 (EBRT)17.6 (\))]TJ ET EMC 0 0 0 SCN q 1 0 0 1 23.544 493.1062 cm 0 0 m 122.235 0 l S Q /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 23.544 494.2717 Tm (Dose and Fractionation)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 477.7717 Tm [(Little evidence exists for appropriate treatment volumes for thyroid carcinoma. ) 37.7 (A)36.9 ( wide variety of dose regimens exists in the literature, and )]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.544 465.7717 Tm (the most common practice in published institutional and multi)Tj /Span<>> BDC (-)Tj EMC (institutional reports are described here.)Tj ET EMC /Span <>BDC BT 9 0 0 9 559.563 469.7717 Tm (15)Tj /Span<>> BDC (-)Tj EMC (21)Tj ET EMC /Span <>BDC BT 11 0 0 11 582.5816 465.7717 Tm ( The treating radiation oncologist )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 453.7717 Tm (should use his/her clinical judgment to determine the appropriate volumes, doses, and fractionation for each patient. ) Tj ET EMC q 1 0 0 1 23.544 431.6062 cm 0 0 m 346.419 0 l S Q q 1 0 0 1 23.544 419.6062 cm 0 0 m 80.685 0 l S Q /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 23.544 432.7717 Tm [<0027004c108700480055004800510057004c0044005700480047000f00030030004800470058004f004f00440055005c>74.7 <000f00030052005500030033005200520055004f005c00030027004c108700480055004800510057004c00440057004800470003000b00510052005100100044005100440053004f004400560057004c0046000c0003>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 23.544 420.7717 Tm (Thyroid Cancer)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 404.2717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 404.2717 Tm (Adjuvant RT for high)Tj /Span<>> BDC (-)Tj EMC (risk disease \(after R1 resection\))Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 392.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 392.2717 Tm (Microscopic disease \(thyroid bed, involved resected lymph node )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 380.2717 Tm (regions\): 60\22666 Gy in 1.8\2262 Gy per fraction)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 368.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 368.2717 Tm (Elective nodal regions: 50\22656 Gy in 1.6\2262 Gy per fraction)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 356.2717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 356.2717 Tm (Salvage RT after R2 resection or inoperable patients )Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 344.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 344.2717 Tm (Gross disease: 66\22670 Gy in 1.8\2262 Gy per fraction)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 332.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 332.2717 Tm (Microscopic disease \(thyroid bed, involved resected lymph node )Tj ET EMC /Span <>BDC BT 11 0 0 11 37.944 320.2717 Tm (regions\): 60\22666 Gy in 1.8\2262 Gy per fraction)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 308.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 308.2717 Tm (Elective nodal regions: 50\22656 Gy in 1.6\2262 Gy per fraction)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 296.2717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 30.4512 296.2717 Tm (Palliative RT of metastases)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 284.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 284.2717 Tm (Bony or soft)Tj /Span<>> BDC (-)Tj EMC (tissue metastases)Tj ET EMC /Span <>BDC BT 9 0 0 9 201.3608 288.2717 Tm (22)Tj ET EMC /Span <>BDC BT 11 0 0 11 211.3716 284.2717 Tm ( )Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 46.9796 272.2717 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 41.544 272.2717 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 50.0357 272.2717 Tm (For patients with oligometastatic disease and good performance )Tj ET EMC /Span <>BDC BT 11 0 0 11 50.184 260.2717 Tm (status consider higher doses \(45\22660 Gy\) in 1.8\2262 Gy daily )Tj ET EMC /Span <>BDC BT 11 0 0 11 50.184 248.2717 Tm (fractions, or SBRT following principles for treatment of )Tj ET EMC /Span <>BDC BT 11 0 0 11 50.184 236.2717 Tm (oligometastases )Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 46.9796 224.2717 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 41.544 224.2717 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 50.0357 224.2717 Tm (For patients with widely metastatic disease and/or poor )Tj ET EMC /Span <>BDC BT 11 0 0 11 50.184 212.2717 Tm [(performance status limiting life expectancy)74.2 (, consider 8 Gy in 1 )]TJ ET EMC /Span <>BDC BT 11 0 0 11 50.184 200.2717 Tm (fraction; 20 Gy in 5 daily fractions; 30 Gy in 10 daily fractions)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 27.144 188.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 38.144 188.2717 Tm (CNS metastases)Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 46.9796 176.2717 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 41.544 176.2717 Tm <00a1>Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 50.0357 176.2717 Tm <0094001700030050004800570044005600570044005600480056000300b100030046005200510056004c00470048005500030056005700480055004800520057004400460057004c00460003005500440047004c0052005600580055004a00480055005c0003000b003600350036000c00030048004c0057004b004800550003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 50.184 164.2717 Tm (following surgical resection or as monotherapy)Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 46.9796 152.2717 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 41.544 152.2717 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 50.0357 152.2717 Tm (Multiple metastases:)Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 56.6617 140.2717 Tm ( )Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 50.544 140.2717 Tm <96>Tj ET EMC /Span <>BDC BT 11 0 0 11 59.544 140.2717 Tm (Consider enrollment on clinical trial for SRS versus WBRT )Tj ET EMC /Span <>BDC BT 11 0 0 11 59.544 128.2717 Tm (\(with or without hippocampal avoidance\))Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 56.6617 116.2717 Tm ( )Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 50.544 116.2717 Tm <96>Tj ET EMC /Span <>BDC BT 11 0 0 11 59.544 116.2717 Tm (Whole brain radiation \226 30 Gy in 10 daily fractions; consider 45 )Tj ET EMC /Span <>BDC BT 11 0 0 11 59.544 104.2717 Tm (Gy in 1.8 Gy daily fractions for good performance status)Tj ET EMC /Span <>BDC BT 9 0 0 9 353.5577 108.2717 Tm (23,24)Tj ET EMC q 1 0 0 1 402 431.6062 cm 0 0 m 139.369 0 l S Q /Span <>BDC BT 11 0 0 11 402 432.7717 Tm (Anaplastic Thyroid Cancer)Tj ET EMC /Span <>BDC BT 11 0 0 11 402 416.2717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9072 416.2717 Tm (Adjuvant RT after R0 or R1 resection)Tj ET EMC /Span <>BDC BT 9 0 0 9 600.8379 420.2717 Tm (14,25)Tj /Span<>> BDC (-)Tj EMC (27)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 405.6 404.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 404.2717 Tm (Microscopic disease/high)Tj /Span<>> BDC (-)Tj EMC (risk regions: 60\22666 Gy in 1.2 Gy twice)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 416.4 392.2717 Tm (daily fractions or 1.8\2262 Gy daily fractions)Tj ET EMC /Span <>BDC BT 9 0 0 9 630.9806 396.2717 Tm (26,28)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 405.6 380.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 380.2717 Tm (Elective nodal regions can be treated with SIB: 45\22654 Gy in 0.8\2261.0 ) Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 368.2717 Tm (Gy twice)Tj /Span<>> BDC (-)Tj EMC (daily fractions or 1.6\2261.8 Gy once)Tj /Span<>> BDC (-)Tj EMC (daily fraction)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 405.6 356.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 356.2717 Tm (Chemoradiation may be considered on an individual basis.)Tj ET EMC /Span <>BDC BT 9 0 0 9 724.0576 360.2717 Tm (13)Tj ET EMC /Span <>BDC BT 11 0 0 11 402 344.2717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9073 344.2717 Tm (Salvage RT after R2 resection or inoperable patients)Tj ET EMC /Span <>BDC BT 9 0 0 9 682.1562 348.2717 Tm (13,14,26)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 405.6 332.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 332.2717 Tm (Gross disease: 66\22670 Gy in 1.2 Gy twice)Tj /Span<>> BDC (-)Tj EMC (daily fractions or 1.8\2262 Gy )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 320.2717 Tm (daily fractions)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 405.6 308.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 308.2717 Tm (Microscopic disease/high)Tj /Span<>> BDC (-)Tj EMC (risk regions: 60\22666 Gy in 1.2 Gy twice)Tj /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 11 0 0 11 416.4 296.2717 Tm (daily fractions or 1.8\2262 Gy daily fractions)Tj ET EMC /Span <>BDC BT 9 0 0 9 630.9806 300.2717 Tm (12,13)Tj ET EMC /Span <>BDC BT 11 0 0 11 653.5026 296.2717 Tm ( )Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 405.6 284.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 284.2717 Tm (Elective nodal regions can be treated with SIB: 45\22654 Gy in 0.8\2261.0 ) Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 272.2717 Tm (Gy twice)Tj /Span<>> BDC (-)Tj EMC (daily fractions or 1.6\2261.8 Gy once)Tj /Span<>> BDC (-)Tj EMC (daily fraction)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 405.6 260.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 260.2717 Tm (Chemoradiation may be considered on an individual basis.)Tj ET EMC /Span <>BDC BT 9 0 0 9 724.0576 264.2717 Tm (13)Tj ET EMC /Span <>BDC BT 11 0 0 11 402 248.2717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9073 248.2717 Tm (Palliative neck RT)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 405.6 236.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 236.2717 Tm (20 Gy in 5 daily fractions, 30 Gy in 10 daily fractions, 45 Gy in 15 )Tj ET EMC /Span <>BDC BT 11 0 0 11 416.4 224.2717 Tm (daily fractions)Tj ET EMC /Span <>BDC BT 11 0 0 11 402 212.2717 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 408.9073 212.2717 Tm (Palliative RT of metastases)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 405.6 200.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 200.2717 Tm (Bony or soft tissue metastases)Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 425.4356 188.2717 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 420 188.2717 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 428.4917 188.2717 Tm (8 Gy in 1 fraction; 20 Gy in 5 daily fractions; 30 Gy in 10 daily )Tj ET EMC /Span <>BDC BT 11 0 0 11 428.64 176.2717 Tm (fractions)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 405.6 164.2717 Tm <0017>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 416.6 164.2717 Tm (CNS metastases)Tj ET EMC /Span <>BDC BT /Span<>> BDC 11 0 0 11 425.4355 152.2717 Tm ( )Tj EMC ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 420 152.2717 Tm <00a1>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 428.4917 152.2717 Tm (Whole brain radiation \226 30 Gy in 10 daily fractions)Tj ET EMC 0 0.397 0.645 SCN /GS1 gs q 1 0 0 1 707.436 66.2133 cm 0 0 m 59.313 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 11 0 0 11 707.436 67.3789 Tm (References)Tj ET EMC endstream endobj 585 0 obj 16926 endobj %% Contents for page 58 %% Original object ID: 117 0 586 0 obj << /Length 587 0 R >> stream Q q BT /Xi56 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 587 0 obj 245 endobj %% Original object ID: 467 0 588 0 obj [ 2599 0 R 2600 0 R 2601 0 R ] endobj %% Contents for page 59 %% Original object ID: 118 0 589 0 obj << /Length 590 0 R >> stream q endstream endobj 590 0 obj 2 endobj %% Contents for page 59 %% Original object ID: 468 0 591 0 obj << /Length 592 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma)Tj ET EMC /Artifact <>BDC BT /TT1 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC q 0 g /GS1 gs 0 TL/Fm0 Do Q /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm1 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 0.035 Tc -0.035 Tw 11 0 0 11 725.165 35.544 Tm [(THYR)17.3 (-)17.4 (C)]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 11 0 0 11 734.0595 23.544 Tm [(5 )-17.6 (O)-35 (F)-17.4 ( 5)]TJ ET EMC /Span <>BDC BT 0.035 Tc -0.017 Tw 11 0 0 11 212.2253 514.3517 Tm [(PRINCIPLES)17.5 ( )0.6 (OF)17.6 ( )0.6 (RADIA)73.9 (TION)17.3 ( )37.7 (AND)17.2 ( )0.6 (RADIOACTIVE)17.5 ( )0.6 (IODINE)17.4 ( )0.6 (THERAPY)]TJ ET EMC /Span <>BDC BT -0.035 Tw 11 0 0 11 356.6701 502.3517 Tm (REFERENCES)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 0 Tc 0 Tw 8 0 0 8 23.544 493.9997 Tm (1)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 490.9997 Tm [(Edmonds CJ, Hayes S, Kermode JC, )17.9 (Thompson BD. Measurement of serum )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 480.9997 Tm (TSH and thyroid hormones in the management of treatment of thyroid carcinoma ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.304 470.9997 Tm (with radioiodine. Br J Radiol. 1977;50:799)Tj /Span<>> BDC (-)Tj EMC (807.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 463.9997 Tm (2)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 460.9997 Tm (Klubo)Tj /Span<>> BDC (-)Tj EMC 2.891 0 Td [(Gwiezd)-0.7 (zinska J, Burman KD, V)74.5 (an Nostrand D, et al. Radioiodine treatment )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 450.9997 Tm [(of metastatic thyroid cancer: relative ef)17.4 (ficacy and side ef)17.5 (fect profile of preparation )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 440.9997 Tm [(by thyroid hormone withdrawal versus recombinant human thyrotropin. )14.6 (Thyroid. )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 430.9997 Tm (2012;22:310)Tj /Span<>> BDC (-)Tj EMC (317.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 423.9997 Tm (3)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 420.9997 Tm [(T)111 (ala H, Robbi)-0.8 (ns R, Fagin JA, et al. Five)]TJ /Span<>> BDC (-)Tj EMC (year survival is similar in thyroid cancer )Tj ET EMC /Span <>BDC BT 10 0 0 10 29.304 410.9997 Tm (patients with distant metastases prepared for radioactive iodine therapy with ) Tj ET EMC /Span <>BDC BT 10 0 0 10 29.304 400.9997 Tm [(either thyroid hormone withdrawal or recombinant human )14.7 (TSH. J Clin Endocrinol )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 390.9997 Tm [(Metab. 201)73.8 (1;96:2105)]TJ /Span<>> BDC (-)Tj EMC [(21)73.2 (1)74 (1.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 23.544 383.9997 Tm (4)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 380.9997 Tm [(Mallick)-0.7 ( U, Harmer C, )18.3 (Y)74.2 (ap B, et al. )55.5 (Ablation with low)]TJ /Span<>> BDC (-)Tj EMC [(dose)-1.7 ( radioiodine and )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 370.9997 Tm [(thyrotropin alfa in thyroid cancer)53.7 (. N Engl J Med. 2012;366:1674)]TJ /Span<>> BDC (-)Tj EMC (1685.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 363.9997 Tm (5)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 360.9997 Tm [(Schlumberge)-1.1 (r M, Catargi B, Borget I, et al. Strategies of r)0.5 (adioiodine ablation in )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 350.9997 Tm (patients with low)Tj /Span<>> BDC (-)Tj EMC [(risk thyroid cancer)53.5 (. N Engl J Med. 2012;366:1663)]TJ /Span<>> BDC (-)Tj EMC (1673.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 343.9997 Tm (6)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 340.9997 Tm [(Reyno)-0.6 (lds JC. Comparison o)-0.9 (f I)]TJ /Span<>> BDC (-)Tj EMC [(131 )55.1 (Absorbed Radiation d)-1.7 (oses in children and )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 330.9997 Tm [(adults: )55.1 (A)55.1 ( tool for estimating therapeutic I)]TJ /Span<>> BDC (-)Tj EMC (131 doses in children. Robbins J. Ed., )Tj ET EMC /Span <>BDC BT 10 0 0 10 29.304 320.9997 Tm [(T)37.3 (reatment of )18.1 (Thyroid Cancer in Childhood. Proceedings of a W)15.5 (orkshop held Sept )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 310.9997 Tm (10)Tj /Span<>> BDC (-)Tj EMC [(1)73.7 (1, 1992 at the National Institutes of Health, pp 127)]TJ /Span<>> BDC (-)Tj EMC (136, 1994.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 303.9997 Tm (7)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 300.9997 Tm [(Padovani RP)128.6 (, Kasamatsu )17.8 (TS, Nakabashi CC, et al. One month is suf)17.8 (ficient )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 290.9997 Tm (for urinary iodine to return to its baseline value after the use of water) Tj /Span<>> BDC (-)Tj EMC (soluble )Tj ET EMC /Span <>BDC BT 10 0 0 10 29.304 280.9997 Tm (iodinated contrast agents in post)Tj /Span<>> BDC (-)Tj EMC (thyroidectomy patients requiring radioiodine )Tj ET EMC /Span <>BDC BT -0.018 Tw 10 0 0 10 29.304 270.9997 Tm [(therapy)73.8 (. Thryoid. )-18.2 (2012;22:926)]TJ /Span<>> BDC (-)Tj EMC (930.)Tj ET EMC /Span <>BDC BT 0 Tw 8 0 0 8 23.544 263.9997 Tm (8)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 260.9997 Tm [(Nimmons GL, F)0.5 (unk GF)111.1 (, Graham MM, et al. Urinary iodine)-1 ( excretion after contrast )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 250.9997 Tm [(computed tomography scan: implications for radioactive iodine use. JAMA)51.9 ( )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 240.9997 Tm (Otolaryngol Head Neck Surg. 2013;139:479)Tj /Span<>> BDC (-)Tj EMC (482.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 233.9997 Tm (9)Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 29.304 230.9997 Tm [(Stabin MG, B)0.5 (reitz HB. Breast milk excretion of radiopharmaceuticals: )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 220.9997 Tm [(mechanisms, findings, and radiation dosimetry)71.8 (. J Nucl Med. 2000;41:863)]TJ /Span<>> BDC (-)Tj EMC (873.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 213.9997 Tm (10 )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 34.6651 210.9997 Tm [(Holst JP)128.8 (, Burman KD, )55.4 (Atkins F)111 (, et al. Radioiodine therapy for thyroid cancer )]TJ ET EMC /Span <>BDC BT 10 0 0 10 34.6651 200.9997 Tm (and hyperthyroidism in patients with end)Tj /Span<>> BDC (-)Tj EMC (stage renal disease on hemodialysis. )Tj ET EMC /Span <>BDC BT 10 0 0 10 34.6651 190.9997 Tm (Thyroid. 2005;15:1321)Tj /Span<>> BDC (-)Tj EMC (1331.)Tj ET EMC /Span <>BDC BT -0.074 Tc 0.074 Tw 8 0 0 8 23.544 183.9997 Tm [(11)-74.2 ( )]TJ ET EMC /Span <>BDC BT 0 Tc 0 Tw 10 0 0 10 34.0714 180.9997 Tm [(Rao SN, Zafereo M, Dadu R, et al. Patterns of )18.3 (T)37.3 (reatment Failure in )54.4 (Anaplastic )]TJ ET EMC /Span <>BDC BT 10 0 0 10 29.304 170.9997 Tm [(Thyroid Carcinoma. )17.1 (Thyroid. 2017;27:672)]TJ /Span<>> BDC (-)Tj EMC (681.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 163.9997 Tm (12 )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 34.6651 160.9997 Tm [(Heron DE, Karimpour S, Grigsby PW)54.6 (. )55.5 (Anaplastic )17.5 (Thyroid Carcinoma: )]TJ ET EMC /Span <>BDC BT 10 0 0 10 34.6651 150.9997 Tm (Comparison of Conventional Radiotherapy and Hyperfractionation )Tj ET EMC /Span <>BDC BT 10 0 0 10 34.6651 140.9997 Tm [(Chemoradiotherapy in )16.4 (T)55.3 (wo Groups. )55.1 (Am J Clin Oncol. 2002;25:442)]TJ /Span<>> BDC (-)Tj EMC (446.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 133.9997 Tm (13 )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 34.6651 130.9997 Tm [(Pezzi )17.9 (T)74.4 (A, Mohamed )54.9 (ASR, Sheu )18 (T)111 (, et al. Radiation )17.6 (Therapy Dose Is )55 (Associated )]TJ ET EMC /Span <>BDC BT 10 0 0 10 34.6651 120.9997 Tm [(With Improved Survival for Unresected )54.2 (Anaplastic )17.4 (Thyroid Carcinoma: )]TJ ET EMC /Span <>BDC BT 10 0 0 10 34.6651 110.9997 Tm [(Outcomes From the National Cancer Data Base. Cancer)53.4 (. 2017;123:1653)]TJ /Span<>> BDC (-)Tj EMC (1661.)Tj ET EMC /Span <>BDC BT 8 0 0 8 23.544 103.9997 Tm (14 )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 34.6651 100.9997 Tm [(Park JW)55.3 (, Choi SH, )18.2 (Y)91.7 (oon HI, et al. )18.4 (T)37.2 (reatment Outcomes of Radiotherapy for )]TJ ET EMC /Span <>BDC BT 10 0 0 10 34.6651 90.9997 Tm [(Anaplastic )17.5 (Thyroid Cancer)54.2 (. Radiat Oncol J. 2018;36:103)]TJ /Span<>> BDC (-)Tj EMC [(1)73.1 (13.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 402 493.9997 Tm (15 )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 413.1211 490.9997 Tm [(Romesser PB, Sherman EJ, Shaha )54.5 (AR, et al. External Beam Radiotherapy With )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 480.9997 Tm [(or Without Concurrent Chemotherapy in )53.5 (Advanced or Recurrent Non)]TJ /Span<>> BDC (-)Tj EMC (Anaplastic )Tj ET EMC /Span <>BDC BT 10 0 0 10 413.1211 470.9997 Tm (Non)Tj /Span<>> BDC (-)Tj EMC [(Medullary )16.8 (Thyroid Cancer)54.2 (. J Surg Oncol. 2014;1)74 (10:375)]TJ /Span<>> BDC (-)Tj EMC (382.)Tj ET EMC /Span <>BDC BT 8 0 0 8 402 463.9997 Tm (16 )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 413.1211 460.9997 Tm [(V)55.2 (ernat SS, Khalifa J, Sun X, et al. 10)]TJ /Span<>> BDC (-)Tj EMC [(Y)92 (ear Locoregional Control With )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 450.9997 Tm [(Postoperative External Beam Radiotherapy in Patients With Locally )52.4 (Advanced )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 440.9997 Tm (High)Tj /Span<>> BDC (-)Tj EMC (Risk Non)Tj /Span<>> BDC (-)Tj EMC [(Anaplastic )16.2 (Thyroid Carcinoma De Novo or at Relapse, a )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 430.9997 Tm [(Propensity Score )54.6 (Analysis. Cancers \(Basel\). 2019;1)72.7 (1:849.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 402 423.9997 Tm (17 )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 413.1211 420.9997 Tm [(T)37.3 (uttle RM, Rondeau G, Lee NY)128.2 (. )55.5 (A)55.2 ( Risk)]TJ /Span<>> BDC (-)Tj EMC [(Adapted )54.6 (Approach to the Use of )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 410.9997 Tm [(Radioactive Iodine and External Beam Radiation in the )14.9 (T)37.3 (reatment of W)18.3 (ell)]TJ /Span<>> BDC (-)Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 413.1211 400.9997 Tm [(Dif)17.9 (ferentiated )17.6 (Thyroid Cancer)54.3 (. Cancer Control. 201)73.3 (1;18:89)]TJ /Span<>> BDC (-)Tj EMC (95.)Tj ET EMC /Span <>BDC BT 8 0 0 8 402 393.9997 Tm (18 )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 413.1211 390.9997 Tm [(Chen PV)91.4 (, Osborne R, )55.3 (Ahn E, et al. )55.6 (Adjuvant External)]TJ /Span<>> BDC (-)Tj EMC (Beam Radiotherapy in )Tj ET EMC /Span <>BDC BT 10 0 0 10 413.1211 380.9997 Tm (Patients With High)Tj /Span<>> BDC (-)Tj EMC [(Risk W)17.5 (ell)]TJ /Span<>> BDC (-)Tj EMC [(Dif)17.4 (ferentiated )17.6 (Thyroid Cancer)54.2 (. Ear Nose )18.2 (Throat J. )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 370.9997 Tm (2009;88:E01.)Tj ET EMC /Span <>BDC BT 8 0 0 8 402 363.9997 Tm (19 )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 413.1211 360.9997 Tm [(Azrif M, Slevin NJ, Sykes )55.4 (AJ, et al. Patterns of Relapse Following Radiotherapy )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 350.9997 Tm [(for Dif)18.1 (ferentiated )17.6 (Thyroid Cancer: Implication for )17.1 (T)111 (arget V)55 (olume Delineation. )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 340.9997 Tm (Radiother Oncol. 2008;89:105)Tj /Span<>> BDC (-)Tj EMC [(1)72.3 (13.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 402 333.9997 Tm (20 )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 413.1211 330.9997 Tm [(Hu )55 (A, Clark J, Payne RJ, et al. Extrathyroidal Extension in W)17.5 (ell)]TJ /Span<>> BDC (-)Tj EMC [(Dif)17.4 (ferentiated )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 320.9997 Tm [(Thyroid Cancer: Macroscopic vs Microscopic as a Predictor of Outcome. )53.6 (Arch )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 310.9997 Tm (Otolaryngol Head Neck Surg. 2007;133:644)Tj /Span<>> BDC (-)Tj EMC (649.)Tj ET EMC /Span <>BDC BT 8 0 0 8 402 303.9997 Tm (21 )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 413.1211 300.9997 Tm [(Keum KC, Suh )18 (YG, Koom WS, et al. )19.1 (The Role of Postoperative External)]TJ /Span<>> BDC (-)Tj EMC (Beam )Tj ET EMC /Span <>BDC BT 10 0 0 10 413.1211 290.9997 Tm [(Radiotherapy in the Management of Patients With Papillary )15.6 (Thyroid Cancer )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 280.9997 Tm [(Invading the )17.5 (T)37.3 (rachea. Int J Radiat Biol Phys. 2006;65:474)]TJ /Span<>> BDC (-)Tj EMC (480.)Tj ET EMC /Span <>BDC BT 8 0 0 8 402 273.9997 Tm (22 )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 413.1211 270.9997 Tm [(Schlumberger M, Challeton C, De V)72.7 (athaire F)110.6 (, et al. Radioactive Iodine )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 260.9997 Tm [(T)37.3 (reatment and External Radiotherapy for Lung and Bone Metastases From )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 250.9997 Tm (Thyroid Carcinoma. J Nucl Med. 1996;37:598)Tj /Span<>> BDC (-)Tj EMC (605.)Tj ET EMC /Span <>BDC BT 8 0 0 8 402 243.9997 Tm (23 )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 413.1211 240.9997 Tm (McWilliams RR, Giannini C, Hay ID, et al. Management of brain metastases ) Tj ET EMC /Span <>BDC BT 10 0 0 10 413.1211 230.9997 Tm (from thyroid carcinoma: a study of 16 pathologically confirmed cases over 25 ) Tj ET EMC /Span <>BDC BT 10 0 0 10 413.1211 220.9997 Tm (years. Cancer 2003;98:256)Tj /Span<>> BDC (-)Tj EMC (362.)Tj ET EMC /Span <>BDC BT 8 0 0 8 402 213.9997 Tm (24 )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 413.1211 210.9997 Tm [(Osborne JR, Kondraciuk JD, Rice SL, et al. )17.4 (Thyroid cancer brain metastases: )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 200.9997 Tm (Survival and genomic charactristics of a large tertiary care cohort. Clin Nucl Med ) Tj ET EMC /Span <>BDC BT 10 0 0 10 413.1211 190.9997 Tm (2019;44:544)Tj /Span<>> BDC (-)Tj EMC (549.)Tj ET EMC /Span <>BDC BT 8 0 0 8 402 183.9997 Tm (25 )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 413.1211 180.9997 Tm [(Rao SN, Zafereo M, Dadu R, et al. Patterns of )18.3 (T)37.3 (reatment Failure in )54.4 (Anaplastic )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 170.9997 Tm [(Thyroid Carcinoma. )17.1 (Thyroid. 2017;27:672)]TJ /Span<>> BDC (-)Tj EMC (681.)Tj ET EMC /Span <>BDC BT 8 0 0 8 402 163.9997 Tm (26 )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 413.1211 160.9997 Tm [(Heron DE, Karimpour S, Grigsby PW)54.6 (. )55.5 (Anaplastic thyroid carcinoma: comparison )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 150.9997 Tm (of conventional radiotherapy and hyperfractionation chemoradiotherapy in two ) Tj ET EMC /Span <>BDC BT 10 0 0 10 413.1211 140.9997 Tm [(groups. )54.9 (Am J Clin Oncol. 2002;25:442)]TJ /Span<>> BDC (-)Tj EMC (446.)Tj ET EMC /Span <>BDC BT 8 0 0 8 402 133.9997 Tm (27 )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 413.1211 130.9997 Tm [(Saeed NA, Kelly JR, Deshpande HA, et al. )54.1 (Adjuvant External Beam )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 120.9997 Tm [(Radiotherapy for Surgically Resected, Nonmetastatic )52.8 (Anaplastic )17.4 (Thyroid )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 110.9997 Tm [(Cancer)54.5 (. Head Neck. 2020; Online ahead of print.)]TJ ET EMC /Span <>BDC BT 8 0 0 8 402 103.9997 Tm (28 )Tj /Span<>> BDC ( )Tj EMC ET EMC /Span <>BDC BT 10 0 0 10 413.1211 100.9997 Tm [(W)37.3 (ang )17.7 (Y)128.9 (, )18.5 (T)111 (sang R, )55 (Asa S, et al. Clinical outcome of anaplastic thyroid carcinoma )]TJ ET EMC /Span <>BDC BT 10 0 0 10 413.1211 90.9997 Tm (treated with radiotherapy of once)Tj /Span<>> BDC (-)Tj EMC ( and twice)Tj /Span<>> BDC (-)Tj EMC (daily fractionation regimens. )Tj ET EMC /Span <>BDC BT 10 0 0 10 413.1211 80.9997 Tm [(Cancer)54.5 (. 2006;107:1786)]TJ /Span<>> BDC (-)Tj EMC (1792.)Tj ET EMC endstream endobj 592 0 obj 22053 endobj %% Contents for page 59 %% Original object ID: 119 0 593 0 obj << /Length 594 0 R >> stream Q q BT /Xi57 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 594 0 obj 245 endobj %% Original object ID: 470 0 595 0 obj [ 2602 0 R 2603 0 R 2604 0 R 2605 0 R ] endobj %% Contents for page 60 %% Original object ID: 120 0 596 0 obj << /Length 597 0 R >> stream q endstream endobj 597 0 obj 2 endobj %% Contents for page 60 %% Original object ID: 471 0 598 0 obj << /Length 599 0 R >> stream /Span <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 11 0 0 11 23.544 67.3789 Tm [(Used with permission of the )54.1 (American College of Surgeons, Chicago, Illinois. )15.4 (The original source for this information is the )53.5 (AJCC Cancer Staging Manual, )]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.544 56.3789 Tm (Eighth Edition \(2017\) published by Springer International Publishing.)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.544 514.3517 Tm (American Joint Committee on Cancer \(AJCC\))Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 23.544 502.3517 Tm <0037003100300003003600570044004a004c0051004a000300290052005500030037004b005c00550052004c0047>Tj /Span<>> BDC <0010>Tj EMC [<0027004c108700480055004800510057004c004400570048004700030044005100470003>39.4 <0024005100440053004f004400560057004c004600030026004400550046004c00510052005000440003>]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 373.0679 502.3517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 490.3517 Tm (\(8th ed., 2017\))Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 23.544 478.3517 Tm [(T)37.3 (able 1. )]TJ ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 67.1519 478.3517 Tm [<0027004800bf0051004c0057004c005200510056000300490052005500030037>111.8 <000f00030031000f00030030>]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 27.544 461.8434 Tm (T)Tj ET EMC /Span <>BDC BT 11 0 0 11 67.492 461.8434 Tm [(Primary T)73.9 (umor)]TJ ET EMC /Span <>BDC BT 11 0 0 11 27.544 445.8351 Tm (TX)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 67.492 445.8351 Tm (Primary tumor cannot be assessed)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 27.544 429.8268 Tm (T0)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 67.492 429.8268 Tm (No evidence of primary tumor)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 27.544 413.8185 Tm (T1)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 67.492 413.8185 Tm [<0037>37.3 <00580050005200550003009400150003004600500003005200550003004f0048005600560003004c00510003004a005500480044005700480056005700030047004c0050004800510056004c005200510003004f004c0050004c00570048004700030057005200030057004b00480003>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 67.492 402.8185 Tm (thyroid)Tj ET EMC /Span <>BDC BT 11 0 0 11 37.12 386.8102 Tm (T1a)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 67.492 386.8102 Tm [<0037>37.3 <005800500052005500030094001400030046005000030003004c00510003004a005500480044005700480056005700030047004c0050004800510056004c005200510003004f004c0050004c00570048004700030057005200030057004b004800030057004b005c00550052004c0047>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 37.12 370.8019 Tm (T1b)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 67.492 370.8019 Tm [<0037>37.3 <005800500052005500030021001400030046005000030045005800570003009400150003004600500003004c00510003004a005500480044005700480056005700030047004c0050004800510056004c005200510003004f004c0050004c00570048004700030057005200030057004b00480003>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 67.492 359.8019 Tm (thyroid)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 27.544 343.7936 Tm (T2)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 67.492 343.7936 Tm [<0037>37.3 <005800500052005500030021001500030046005000030045005800570003009400170003004600500003004c00510003004a005500480044005700480056005700030047004c0050004800510056004c005200510003004f004c0050004c00570048004700030057005200030057004b00480003>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 67.492 332.7936 Tm (thyroid)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 27.544 316.7853 Tm (T3)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 67.492 316.7853 Tm [(T)37.3 (umor >4 cm limited to the thyroid, or gross extrathyroidal )]TJ ET EMC /Span <>BDC BT 11 0 0 11 67.492 305.7853 Tm (extension invading only strap muscles)Tj ET EMC /Span <>BDC BT 11 0 0 11 37.12 289.777 Tm (T3a)Tj ET EMC /Span <>BDC BT 11 0 0 11 67.492 289.777 Tm [(T)37.3 (umor >4 cm limited to the thyroid)]TJ ET EMC /Span <>BDC BT 11 0 0 11 37.12 273.7687 Tm (T3b)Tj ET EMC /Span <>BDC BT 11 0 0 11 67.492 273.7687 Tm (Gross extrathyroidal extension invading only strap muscles )Tj ET EMC /Span <>BDC BT 11 0 0 11 67.492 262.7687 Tm (\(sternohyoid, sternothyroid, thyrohyoid, or omohyoid )Tj ET EMC /Span <>BDC BT 11 0 0 11 67.492 251.7687 Tm (muscles\) from a tumor of any size)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 27.544 235.7604 Tm (T4)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 67.492 235.7604 Tm (Includes gross extrathyroidal extension beyond the strap )Tj ET EMC /Span <>BDC BT 11 0 0 11 67.492 224.7604 Tm (muscle)Tj ET EMC /Span <>BDC BT 11 0 0 11 37.12 208.7521 Tm (T4a)Tj ET EMC /Span <>BDC BT 11 0 0 11 67.492 208.7521 Tm (Gross extrathyroidal extension invading subcutaneous soft )Tj ET EMC /Span <>BDC BT 11 0 0 11 67.492 197.7521 Tm (tissues, larynx, trachea, esophagus, or recurrent laryngeal )Tj ET EMC /Span <>BDC BT 11 0 0 11 67.492 186.7521 Tm (nerve from a tumor of any size)Tj ET EMC /Span <>BDC BT 11 0 0 11 37.12 170.7438 Tm (T4b)Tj ET EMC /Span <>BDC BT 11 0 0 11 67.492 170.7438 Tm (Gross extrathyroidal extension invading prevertebral fascia )Tj ET EMC /Span <>BDC BT 11 0 0 11 67.492 159.7438 Tm (or encasing the carotid artery or mediastinal vessels from a )Tj ET EMC /Span <>BDC BT 11 0 0 11 67.492 148.7438 Tm (tumor of any size)Tj ET EMC /Span <>BDC BT /TT3 1 Tf 11 0 0 11 23.544 133.7438 Tm [(Note: )37.1 (All categories may be subdivided: \(s\) solitary tumor and \(m\) )]TJ ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 23.544 122.7438 Tm <00500058004f0057004c0049005200460044004f0003005700580050005200550003000b0057004b00480003004f00440055004a0048005600570003004700480057004800550050004c00510048005600030057004b004800030046004f004400560056004c00bf004600440057004c00520051000c0011>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 412.96 462.1117 Tm (N)Tj ET EMC /Span <>BDC BT 11 0 0 11 454.96 462.1117 Tm [(Regional L)37.8 (ymph Nodes)]TJ ET EMC /Span <>BDC BT 11 0 0 11 412.96 446.1034 Tm (NX)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 454.96 446.1034 Tm (Regional lymph nodes cannot be assessed)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 412.96 430.0951 Tm (N0)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 454.96 430.0951 Tm (No evidence of locoregional lymph node metastasis)Tj ET EMC /Span <>BDC BT 11 0 0 11 423.76 414.0868 Tm (N0a)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 454.96 414.0868 Tm <0032005100480003005200550003005000520055004800030046005c00570052004f0052004a004c00460044004f004f005c0003005200550003004b004c005600570052004f0052004a004c00460044004f004f005c0003004600520051>Tj /Span<>> BDC <00bf>Tj EMC <00550050004800470003004500480051004c004a00510003>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 454.96 403.0868 Tm (lymph nodes)Tj ET EMC /Span <>BDC BT 11 0 0 11 423.76 387.0785 Tm (N0b)Tj ET EMC /Span <>BDC BT 11 0 0 11 454.96 387.0785 Tm (No radiologic or clinical evidence of locoregional lymph )Tj ET EMC /Span <>BDC BT 11 0 0 11 454.96 376.0785 Tm (node metastasis)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 412.96 360.0702 Tm (N1)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 454.96 360.0702 Tm (Metastasis to regional nodes)Tj ET EMC /Span <>BDC BT 11 0 0 11 423.76 344.0619 Tm (N1a)Tj ET EMC /Span <>BDC BT 11 0 0 11 454.96 344.0619 Tm (Metastasis to level VI or VII \(pretracheal, paratracheal, or )Tj ET EMC /Span <>BDC BT 11 0 0 11 454.96 333.0619 Tm (prelaryngeal/Delphian, or upper mediastinal\) lymph nodes. )Tj ET EMC /Span <>BDC BT 11 0 0 11 454.96 322.0619 Tm (This can be unilateral or bilateral disease)Tj ET EMC /Span <>BDC BT 11 0 0 11 423.76 306.0536 Tm (N1b)Tj ET EMC /Span <>BDC BT 11 0 0 11 454.96 306.0536 Tm (Metastasis to unilateral, bilateral, or contralateral )Tj ET EMC /Span <>BDC BT 11 0 0 11 454.96 295.0536 Tm [(lateral neck lymph nodes \(levels I, II, III, IV)92.2 (, or V\) or )]TJ ET EMC /Span <>BDC BT 11 0 0 11 454.96 284.0536 Tm (retropharyngeal lymph nodes)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 412.96 244.0453 Tm (M)Tj ET EMC /Span <>BDC BT 11 0 0 11 438.988 244.0453 Tm (Distant Metastasis)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 412.96 228.037 Tm (M0)Tj ET EMC /Span <>BDC BT 11 0 0 11 438.988 228.037 Tm (No distant metastasis)Tj ET EMC /Span <>BDC BT 11 0 0 11 412.96 212.0287 Tm (M1)Tj ET EMC /Span <>BDC BT 11 0 0 11 438.988 212.0287 Tm (Distant metastasis)Tj ET EMC /Artifact <>BDC BT /TT1 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma)Tj ET EMC /Artifact <>BDC BT /TT0 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm0 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT1 1 Tf -0.038 Tc 0.038 Tw 11 0 0 11 744.646 23.544 Tm [(S)-73.1 (T-)-38 (1)]TJ ET EMC /GS1 gs q 1 0 0 1 714.079 87.3062 cm 0 0 m 54.377 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 0 Tc 0 Tw 11 0 0 11 714.079 88.4717 Tm (Continued)Tj ET EMC endstream endobj 599 0 obj 12314 endobj %% Contents for page 60 %% Original object ID: 121 0 600 0 obj << /Length 601 0 R >> stream Q q BT /Xi58 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 601 0 obj 245 endobj %% Original object ID: 472 0 602 0 obj << /BaseFont /KMZZIE+Arial-ItalicMT /DescendantFonts 2606 0 R /Encoding /Identity-H /Subtype /Type0 /ToUnicode 2607 0 R /Type /Font >> endobj %% Original object ID: 475 0 603 0 obj [ 2609 0 R 2610 0 R 2611 0 R 2612 0 R ] endobj %% Contents for page 61 %% Original object ID: 122 0 604 0 obj << /Length 605 0 R >> stream q endstream endobj 605 0 obj 2 endobj %% Contents for page 61 %% Original object ID: 476 0 606 0 obj << /Length 607 0 R >> stream /Span <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 11 0 0 11 416.5884 514.3517 Tm [(Histopathologic T)75.4 (ype)]TJ ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 416.5884 490.3517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 423.4956 490.3517 Tm (Papillary thyroid carcinoma \(PTC\))Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 420.1884 478.3517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 431.1884 478.3517 Tm (Papillary microcarcinoma )Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 420.1884 466.3517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 431.1884 466.3517 Tm (Follicular variant of PTC)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 420.1884 454.3517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 431.1884 454.3517 Tm (Encapsulated variant of PTC)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 420.1884 442.3517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 431.1884 442.3517 Tm (Papillary microcarcinoma)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 420.1884 430.3517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 431.1884 430.3517 Tm (Columnar cell variant of PTC)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 420.1884 418.3517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 431.1884 418.3517 Tm (Oncocytic variant of of PTC)Tj ET EMC /Span <>BDC BT 11 0 0 11 416.5884 406.3517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 423.4956 406.3517 Tm (Follicular thyroid carcinoma \(FTC\), NOS)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 420.1884 394.3517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 431.1884 394.3517 Tm (FTC, minimally invasive)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 420.1884 382.3517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 431.1884 382.3517 Tm (FTC, encapsulated angioinvasive)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 420.1884 370.3517 Tm <0017>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 431.1884 370.3517 Tm (FTC, widely invasive)Tj ET EMC /Span <>BDC BT 11 0 0 11 416.5884 358.3517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 423.4956 358.3517 Tm (Hürthle cell carcinoma)Tj ET EMC /Span <>BDC BT 11 0 0 11 416.5884 346.3517 Tm <9520>Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 423.4956 346.3517 Tm <0033005200520055004f005c00030047004c108700480055004800510057004c004400570048004700030057004b005c00550052004c004700030046004400550046004c00510052005000440003000b005800560048004700030049005200550003004c005100560058004f004400550003>Tj ET EMC /Span <>BDC BT 11 0 0 11 423.7884 334.3517 Tm <0046004400550046004c00510052005000440003004400560003004400030056005800450057005c0053004800030052004900030053005200520055004f005c00030047004c108700480055004800510057004c0044005700480047000c0003>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 416.5884 322.3517 Tm <9520>Tj ET EMC /Span <>BDC BT 11 0 0 11 423.4956 322.3517 Tm (Anaplastic thyroid carcinoma )Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 23.544 514.3517 Tm (American Joint Committee on Cancer \(AJCC\))Tj ET EMC /Span <>BDC BT /C2_2 1 Tf 11 0 0 11 23.544 502.3517 Tm <0037003100300003003600570044004a004c0051004a000300290052005500030037004b005c00550052004c0047>Tj /Span<>> BDC <0010>Tj EMC 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95.7023 Tm (Any N)Tj ET EMC /Span <>BDC BT 11 0 0 11 203.908 95.7023 Tm (M1)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 67.3789 Tm [(Used with permission of the )54.1 (American College of Surgeons, Chicago, Illinois. )15.4 (The original source for this information is the )53.5 (AJCC Cancer Staging Manual, )]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.544 56.3789 Tm (Eighth Edition \(2017\) published by Springer International Publishing.)Tj ET EMC /Artifact <>BDC BT /TT0 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma)Tj ET EMC /Artifact <>BDC BT /TT1 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm0 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf -0.038 Tc 0.038 Tw 11 0 0 11 744.646 23.544 Tm [(S)-73.1 (T-)-38 (2)]TJ ET EMC /GS1 gs q 1 0 0 1 714.079 87.3062 cm 0 0 m 54.377 0 l S Q /Span <>BDC BT 0 0.397 0.645 scn 0 Tc 0 Tw 11 0 0 11 714.079 88.4717 Tm (Continued)Tj ET EMC endstream endobj 607 0 obj 13517 endobj %% Contents for page 61 %% Original object ID: 123 0 608 0 obj << /Length 609 0 R >> stream Q q BT /Xi59 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 609 0 obj 245 endobj %% Original object ID: 478 0 610 0 obj [ 2613 0 R 2614 0 R 2615 0 R ] endobj %% Contents for page 62 %% Original object ID: 124 0 611 0 obj << /Length 612 0 R >> stream q endstream endobj 612 0 obj 2 endobj %% Contents for page 62 %% Original object ID: 479 0 613 0 obj << /Length 614 0 R >> stream /Span <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 11 0 0 11 23.544 514.3517 Tm (American Joint Committee on Cancer \(AJCC\))Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 502.3517 Tm (TNM Staging For Thyroid-Medullary Carcinoma )Tj ET EMC /Span <>BDC BT 11 0 0 11 272.897 502.3517 Tm ( )Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 490.3517 Tm (\(8th ed., 2017\))Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 23.544 466.3517 Tm [(T)37.3 (able 3. )]TJ ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 67.1519 466.3517 Tm [<0027004800bf0051004c0057004c005200510056000300490052005500030037>111.8 <000f00030031000f00030030>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 27.544 449.8434 Tm (T)Tj ET EMC /Span <>BDC BT 11 0 0 11 68.932 449.8434 Tm [(Primary T)73.9 (umor)]TJ ET EMC /Span <>BDC BT 11 0 0 11 27.544 433.8351 Tm (TX)Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 68.932 433.8351 Tm (Primary tumor cannot be assessed)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 27.544 417.8268 Tm (T0)Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 68.932 417.8268 Tm (No evidence of primary tumor)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 27.544 401.8185 Tm (T1)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 68.932 401.8185 Tm [<0037>37.3 <00580050005200550003009400150003004600500003005200550003004f0048005600560003004c00510003004a005500480044005700480056005700030047004c0050004800510056004c005200510003004f004c0050004c00570048004700030057005200030057004b004800030057004b005c00550052004c0047>]TJ ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 38.56 385.8102 Tm (T1a)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 68.932 385.8102 Tm [<0037>37.3 <005800500052005500030094001400030046005000030003004c00510003004a005500480044005700480056005700030047004c0050004800510056004c005200510003004f004c0050004c00570048004700030057005200030057004b004800030057004b005c00550052004c0047>]TJ ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 38.56 369.8019 Tm (T1b)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 68.932 369.8019 Tm [<0037>37.3 <005800500052005500030021001400030046005000030045005800570003009400150003004600500003004c00510003004a005500480044005700480056005700030047004c0050004800510056004c005200510003004f004c0050004c00570048004700030057005200030057004b004800030057004b005c00550052004c0047>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 27.544 353.7936 Tm (T2)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 68.932 353.7936 Tm [<0037>37.3 <005800500052005500030021001500030046005000030045005800570003009400170003004600500003004c00510003004a005500480044005700480056005700030047004c0050004800510056004c005200510003004f004c0050004c00570048004700030057005200030057004b004800030057004b005c00550052004c0047>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 27.544 337.7853 Tm (T3)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 68.932 337.7853 Tm [<0037>37.3 <00580050005200550003009500170003004600500003005200550003005a004c0057004b00030048005b0057005500440057004b005c00550052004c00470044004f00030048005b0057004800510056004c00520051>]TJ ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 38.56 321.777 Tm (T3a)Tj ET EMC /Span <>BDC BT /C2_1 1 Tf 11 0 0 11 68.932 321.777 Tm [<0037>37.3 <00580050005200550003009500170003004600500003004c00510003004a005500480044005700480056005700030047004c0050004800510056004c005200510003004f004c0050004c00570048004700030057005200030057004b004800030057004b005c00550052004c0047>]TJ ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 38.56 305.7687 Tm (T3b)Tj ET EMC /Span <>BDC BT -0.001 Tw 11 0 0 11 68.932 305.7687 Tm [(T)37.3 (umor of )0.5 (any size with gross extrathyroidal extension invading only )]TJ ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 68.932 294.7687 Tm (strap muscles \(sternohyoid, sternothyroid, thyrohyoid, or omohyoid )Tj ET EMC /Span <>BDC BT 11 0 0 11 68.932 283.7687 Tm (muscles\))Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 27.544 267.7604 Tm (T4)Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 68.932 267.7604 Tm (Advanced disease)Tj ET EMC /Span <>BDC BT 11 0 0 11 38.56 251.7521 Tm (T4a)Tj ET EMC /Span <>BDC BT 11 0 0 11 68.932 251.7521 Tm (Moderately advanced disease; tumor of any size with gross )Tj ET EMC /Span <>BDC BT 11 0 0 11 68.932 240.7521 Tm (extrathyroidal extension into the nearby tissues of the neck, )Tj ET EMC /Span <>BDC BT 11 0 0 11 68.932 229.7521 Tm (including subcutaneous soft tissue, larynx, trachea, esophagus, or )Tj ET EMC /Span <>BDC BT 11 0 0 11 68.932 218.7521 Tm (recurrent laryngeal 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392.3019 Tm (Metastasis to level VI or VII \(pretracheal, paratracheal, )Tj ET EMC /Span <>BDC BT 11 0 0 11 488.908 381.3019 Tm (or prelaryngeal/Delphian, or upper mediastinal\) lymph )Tj ET EMC /Span <>BDC BT 11 0 0 11 488.908 370.3019 Tm [(nodes. )17.8 (This can be unilateral or bilateral disease)]TJ ET EMC /Span <>BDC BT 11 0 0 11 457.708 354.2936 Tm (N1b)Tj ET EMC /Span <>BDC BT 11 0 0 11 488.908 354.2936 Tm (Metastasis to unilateral, bilateral, or contralateral )Tj ET EMC /Span <>BDC BT 11 0 0 11 488.908 343.2936 Tm [(lateral neck lymph nodes \(levels I, II, III, IV)92.2 (, or V\) or )]TJ ET EMC /Span <>BDC BT 11 0 0 11 488.908 332.2936 Tm (retropharyngeal lymph nodes)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 431.68 292.2853 Tm (M)Tj ET EMC /Span <>BDC BT 11 0 0 11 457.708 292.2853 Tm (Distant Metastasis)Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 431.68 276.277 Tm (M0)Tj ET EMC /Span <>BDC BT 11 0 0 11 457.708 276.277 Tm (No distant metastasis)Tj ET EMC /Span <>BDC BT 11 0 0 11 431.68 260.2687 Tm (M1)Tj ET EMC /Span <>BDC BT 11 0 0 11 457.708 260.2687 Tm (Distant metastasis)Tj ET EMC /Span <>BDC BT /TT1 1 Tf -0.001 Tw 11 0 0 11 427.68 231.7517 Tm [(T)37.3 (able 2. )]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 471.2673 231.7517 Tm (AJCC Prognostic Stage Groups)Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 501.52 215.2434 Tm (T)Tj ET EMC /Span <>BDC BT 11 0 0 11 543.904 215.2434 Tm (N)Tj ET EMC /Span <>BDC BT 11 0 0 11 586.48 215.2434 Tm (M)Tj ET EMC /Span <>BDC BT 11 0 0 11 431.68 199.2351 Tm (Stage I)Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 501.52 199.2351 Tm (T1)Tj ET EMC /Span <>BDC BT 11 0 0 11 543.904 199.2351 Tm (N0)Tj ET EMC /Span <>BDC BT 11 0 0 11 586.48 199.2351 Tm (M0)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 431.68 183.2268 Tm (Stage II)Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 501.52 183.2268 Tm (T2)Tj ET EMC /Span <>BDC BT 11 0 0 11 543.904 183.2268 Tm (N0)Tj ET EMC /Span <>BDC BT 11 0 0 11 586.48 183.2268 Tm (M0)Tj ET EMC /Span <>BDC BT 11 0 0 11 501.52 167.2185 Tm (T3)Tj ET EMC /Span <>BDC BT 11 0 0 11 543.904 167.2185 Tm (N0)Tj ET EMC /Span <>BDC BT 11 0 0 11 586.48 167.2185 Tm (M0)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 431.68 151.2102 Tm (Stage III)Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 501.52 151.2102 Tm (T1-T3)Tj ET EMC /Span <>BDC BT 11 0 0 11 543.904 151.2102 Tm (N1a)Tj ET EMC /Span <>BDC BT 11 0 0 11 586.48 151.2102 Tm (M0)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 431.68 135.2019 Tm [(Stage IV)74.4 (A)]TJ ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 501.52 135.2019 Tm (T4a)Tj ET EMC /Span <>BDC BT 11 0 0 11 543.904 135.2019 Tm (Any N)Tj ET EMC /Span <>BDC BT 11 0 0 11 586.48 135.2019 Tm (M0)Tj ET EMC /Span <>BDC BT 11 0 0 11 501.52 119.1936 Tm (T1-T3)Tj ET EMC /Span <>BDC BT 11 0 0 11 543.904 119.1936 Tm (N1b)Tj ET EMC /Span <>BDC BT 11 0 0 11 586.48 119.1936 Tm (M0)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 431.68 103.1853 Tm (Stage IVB)Tj ET EMC /Span <>BDC BT /TT2 1 Tf 11 0 0 11 501.52 103.1853 Tm (T4)Tj ET EMC /Span <>BDC BT 11 0 0 11 543.904 103.1853 Tm (N0)Tj ET EMC /Span <>BDC BT 11 0 0 11 586.48 103.1853 Tm (M0)Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 431.68 87.177 Tm (Stage IVC)Tj ET EMC /Span <>BDC BT /TT2 1 Tf -0.018 Tw 11 0 0 11 501.52 87.177 Tm (Any T)Tj ET EMC /Span <>BDC BT 0 Tw 11 0 0 11 543.904 87.177 Tm (Any N)Tj ET EMC /Span <>BDC BT 11 0 0 11 586.48 87.177 Tm (M1)Tj ET EMC /Span <>BDC BT 11 0 0 11 23.544 67.3789 Tm [(Used with permission of the )54.1 (American College of Surgeons, Chicago, Illinois. )15.4 (The original source for this information is the )53.5 (AJCC Cancer Staging Manual, )]TJ ET EMC /Span <>BDC BT 11 0 0 11 23.544 56.3789 Tm (Eighth Edition \(2017\) published by Springer International Publishing.)Tj ET EMC /Artifact <>BDC BT /TT0 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma)Tj ET EMC /Artifact <>BDC BT /TT2 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm0 Do Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf -0.038 Tc 0.038 Tw 11 0 0 11 744.6459 23.544 Tm [(S)-73.1 (T-)-38 (3)]TJ ET EMC endstream endobj 614 0 obj 14847 endobj %% Contents for page 62 %% Original object ID: 125 0 615 0 obj << /Length 616 0 R >> stream Q q BT /Xi60 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 616 0 obj 245 endobj %% Original object ID: 481 0 617 0 obj [ 2616 0 R 2617 0 R 2618 0 R ] endobj %% Contents for page 63 %% Original object ID: 126 0 618 0 obj << /Length 619 0 R >> stream q endstream endobj 619 0 obj 2 endobj %% Contents for page 63 %% Original object ID: 482 0 620 0 obj << /Length 621 0 R >> stream /Artifact <>BDC BT /CS0 cs 0 0 0 scn /GS0 gs /TT0 1 Tf 18 0 0 18 186.6168 571.3176 Tm [(NCCN Guidelines V)55.5 (ersion 2.2020)]TJ ET EMC /Artifact <>BDC BT 18 0 0 18 186.6168 549.7176 Tm (Thyroid Carcinoma)Tj ET EMC /Artifact <>BDC BT /TT1 1 Tf 6 0 0 6 23.544 19.1758 Tm [(V)55.2 (ersion 2.2020, 07/15/20 © 2020 National )-0.8 (Comprehensive )-1.2 (Cancer Network)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 223.4159 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 225.9933 19.1758 Tm ( \(NCCN)Tj ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 246.9903 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 249.5677 19.1758 Tm [(\), )55.5 (All rights reserved. NCCN Guidelines)]TJ ET EMC /Artifact <>BDC BT 3.498 0 0 3.498 353.2697 21.1738 Tm Tj ET EMC /Artifact <>BDC BT 6 0 0 6 355.8471 19.1758 Tm [( and this illustration may )-0.8 (not be reproduced in )-1 (any form without the express written permission of )-0.6 (NCCN.)]TJ ET EMC /CS0 CS 0 0.397 0.645 SCN 0.75 w /GS1 gs q 1 0 0 1 651.683 575.1002 cm 0 0 m 116.773 0 l S Q q 1 0 0 1 682.8461 561.9001 cm 0 0 m 85.61 0 l S Q q 1 0 0 1 715.2714 548.7001 cm 0 0 m 53.185 0 l S Q /Artifact <>BDC BT 0 0.397 0.645 scn 11 0 0 11 651.683 576.2657 Tm (NCCN Guidelines Index)Tj ET EMC /Artifact <>BDC BT 11 0 0 11 682.8461 563.0657 Tm [(T)111 (able of Contents)]TJ ET EMC /Artifact <>BDC BT 11 0 0 11 715.2714 549.8657 Tm (Discussion)Tj ET EMC q 0 g 0 G 1 w 0 TL/Fm0 Do Q 0.877 0.91 0.92 scn 82.94 521.86 626.12 -16.008 re f 0.932 0.948 0.952 scn 82.94 489.843 78.7 -16.008 re 161.64 489.843 547.42 -16.008 re 82.94 457.827 78.7 -16.008 re 161.64 457.827 547.42 -16.008 re f 0 0 0 SCN 1 w /GS2 gs q 1 0 0 1 82.44 505.8517 cm 0 0 m 79.2 0 l S Q q 1 0 0 1 161.64 505.8517 cm 0 0 m 547.92 0 l S Q q 1 0 0 1 709.06 506.3517 cm 0 0 m 0 15.008 l S Q q 1 0 0 1 82.44 521.86 cm 0 0 m 79.2 0 l S Q q 1 0 0 1 82.94 506.3517 cm 0 0 m 0 15.008 l S Q q 1 0 0 1 161.64 521.86 cm 0 0 m 547.92 0 l S Q q 1 0 0 1 82.94 489.8434 cm 0 0 m 0 15.508 l S Q q 1 0 0 1 709.06 489.8434 cm 0 0 m 0 15.508 l S Q q 1 0 0 1 82.94 473.8351 cm 0 0 m 0 16.008 l S Q q 1 0 0 1 709.06 473.8351 cm 0 0 m 0 16.008 l S Q q 1 0 0 1 82.94 457.8268 cm 0 0 m 0 16.008 l S Q q 1 0 0 1 709.06 457.8268 cm 0 0 m 0 16.008 l S Q q 1 0 0 1 82.94 442.3185 cm 0 0 m 0 15.508 l S Q q 1 0 0 1 709.06 442.3185 cm 0 0 m 0 15.508 l S Q q 1 0 0 1 82.44 441.8185 cm 0 0 m 79.2 0 l S Q q 1 0 0 1 161.64 441.8185 cm 0 0 m 547.92 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 11 0 0 11 275.2793 509.8517 Tm (NCCN Categories of Evidence and Consensus)Tj ET EMC /Span <>BDC BT 11 0 0 11 86.94 493.8434 Tm (Category 1)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 165.64 493.8434 Tm (Based upon high)Tj /Span<>> BDC (-)Tj EMC (level evidence, there is uniform NCCN consensus that the intervention is appropriate.) Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 86.94 477.8351 Tm (Category 2A)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 165.64 477.8351 Tm (Based upon lower)Tj /Span<>> BDC (-)Tj EMC (level evidence, there is uniform NCCN consensus that the intervention is appropriate.) Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 86.94 461.8268 Tm (Category 2B)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 165.64 461.8268 Tm (Based upon lower)Tj /Span<>> BDC (-)Tj EMC (level evidence, there is NCCN consensus that the intervention is appropriate.) Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 86.94 445.8185 Tm (Category 3)Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 165.64 445.8185 Tm (Based upon any level of evidence, there is major NCCN disagreement that the intervention is appropriate. ) Tj ET EMC /Span <>BDC BT 11 0 0 11 86.94 429.8102 Tm [(All recommendations are category 2A)53.4 ( unless otherwise indicated.)]TJ ET EMC 0.877 0.91 0.92 scn /GS1 gs 81.14 380.77 629.72 -16.008 re f 0.932 0.948 0.952 scn 81.14 336.754 127.06 -28.008 re 208.2 336.754 502.66 -28.008 re f /GS2 gs q 1 0 0 1 80.64 364.762 cm 0 0 m 127.56 0 l S Q q 1 0 0 1 208.2 364.762 cm 0 0 m 503.16 0 l S Q q 1 0 0 1 710.86 365.262 cm 0 0 m 0 15.008 l S Q q 1 0 0 1 80.64 380.7703 cm 0 0 m 127.56 0 l S Q q 1 0 0 1 81.14 365.262 cm 0 0 m 0 15.008 l S Q q 1 0 0 1 208.2 380.7703 cm 0 0 m 503.16 0 l S Q q 1 0 0 1 81.14 336.7537 cm 0 0 m 0 27.508 l S Q q 1 0 0 1 710.86 336.7537 cm 0 0 m 0 27.508 l S Q q 1 0 0 1 81.14 308.7454 cm 0 0 m 0 28.008 l S Q q 1 0 0 1 710.86 308.7454 cm 0 0 m 0 28.008 l S Q q 1 0 0 1 81.14 281.2371 cm 0 0 m 0 27.508 l S Q q 1 0 0 1 710.86 281.2371 cm 0 0 m 0 27.508 l S Q q 1 0 0 1 80.64 280.7371 cm 0 0 m 127.56 0 l S Q q 1 0 0 1 208.2 280.7371 cm 0 0 m 503.16 0 l S Q /Span <>BDC BT 0 0 0 scn /GS0 gs /TT0 1 Tf 11 0 0 11 313.4758 368.762 Tm (NCCN Categories of Preference)Tj ET EMC /Span <>BDC BT 11 0 0 11 85.14 346.7537 Tm (Preferred intervention)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 212.2 352.2537 Tm [<002c00510057004800550059004800510057004c00520051005600030057004b004400570003004400550048000300450044005600480047000300520051000300560058005300480055004c00520055000300481088004600440046005c>72.4 <000f000300560044004900480057005c>74.6 <000f0003004400510047000300480059004c00470048005100460048001e0003004400510047000f0003005a004b0048005100030044005300530055005200530055004c004400570048000f0003>]TJ ET EMC /Span <>BDC BT 11 0 0 11 212.2 341.2537 Tm [<0044108700520055004700440045004c004f004c0057005c>72.9 <0011>]TJ ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 85.14 324.7454 Tm (Other recommended )Tj ET EMC /Span <>BDC BT 11 0 0 11 85.14 312.7454 Tm (intervention)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 212.2 324.2454 Tm <00320057004b004800550003004c00510057004800550059004800510057004c00520051005600030057004b00440057000300500044005c00030045004800030056005200500048005a004b004400570003004f004800560056000300481088004600440046004c005200580056000f00030050005200550048000300570052005b004c0046000f0003005200550003004500440056004800470003005200510003004f004800560056000300500044005700580055004800030047004400570044001e0003>Tj ET EMC /Span <>BDC BT 11 0 0 11 212.2 313.2454 Tm <0052005500030056004c004a0051004c00bf0046004400510057004f005c0003004f00480056005600030044108700520055004700440045004f0048000300490052005500030056004c0050004c004f004400550003005200580057004600520050004800560011>Tj ET EMC /Span <>BDC BT /TT0 1 Tf 11 0 0 11 85.14 296.7371 Tm (Useful in certain )Tj ET EMC /Span <>BDC BT 11 0 0 11 85.14 284.7371 Tm (circumstances)Tj ET EMC /Span <>BDC BT /C2_0 1 Tf 11 0 0 11 212.2 290.7371 Tm <00320057004b004800550003004c00510057004800550059004800510057004c00520051005600030057004b00440057000300500044005c000300450048000300580056004800470003004900520055000300560048004f004800460057004800470003005300440057004c00480051005700030053005200530058004f00440057004c0052005100560003000b0047004800bf0051004800470003005a004c0057004b000300550048004600520050005000480051004700440057004c00520051000c0011>Tj ET EMC /Span <>BDC BT /TT1 1 Tf 11 0 0 11 85.14 268.7288 Tm (All recommendations are considered appropriate.)Tj ET EMC /Span <>BDC BT /TT0 1 Tf -0.039 Tc 0.039 Tw 11 0 0 11 736.5248 23.544 Tm [(C)-74.3 (AT)]TJ /Span<>> BDC 2.014 0 Td (-)Tj EMC 0.333 0 Td (1)Tj ET EMC endstream endobj 621 0 obj 8017 endobj %% Contents for page 63 %% Original object ID: 127 0 622 0 obj << /Length 623 0 R >> stream Q q BT /Xi61 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 623 0 obj 245 endobj %% Original object ID: 484 0 624 0 obj [ 2619 0 R 2620 0 R 2621 0 R ] endobj %% Contents for page 64 %% Original object ID: 128 0 625 0 obj << /Length 626 0 R >> stream q endstream endobj 626 0 obj 2 endobj %% Contents for page 64 %% Original object ID: 485 0 627 0 obj << /Length 628 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 740.28 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 756.84 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 760.56 23.76 Tm (1)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC /TT1 1 Tf 15.96 -0 0 15.96 23.52 509.4 Tm [(Discu)2 (ssi)-7.7 (o)2 (n)]TJ 5.346 0 Td ( )Tj EMC /TOCI <>BDC 0.01 Tc -0.001 Tw 12.96 -0 0 12.96 23.52 479.04 Tm [(T)0.6 (a)1.2 (b)0.6 (l)1 (e)1.2 ( o)0.6 (f C)0.5 (o)0.6 (n)0.7 (te)1.1 (n)0.7 (ts)]TJ 0 Tc 0 Tw 8.602 0 Td ( )Tj EMC /TOCI <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 23.52 455.04 Tm [(O)-17.5 (ve)-11.2 (r)-15.2 (vi)-17.4 (e)10.5 (w)]TJ 0 Tc 0 Tw 4.5 0 Td ( )Tj 0.016 Tc 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(i)2.8 (on and)10.7 ( D)2.7 (i)2.8 (ag)-11.1 (no)10.7 (s)-1.9 (i)2.8 (s)]TJ 0 Tc 0 Tw 14.957 0 Td ( )Tj 0.016 Tc -0.016 Tw 0.185 0 Td [(.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)]TJ 9.391 0 Td [(.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)]TJ 0 Tc 0 Tw 4.109 0 Td ( )Tj -0.007 Tc 0.007 Tw 0.261 0 Td (MS)Tj 0 Tc 0 Tw 1.5 0 Td (-)Tj EMC ET BT /Reference <>BDC 0.009 Tc -0.009 Tw 11.04 -0 0 11.04 755.52 348.36 Tm (29)Tj EMC /Span <>BDC /TT3 1 Tf 0 Tc 0 Tw ( )Tj EMC /TOCI <>BDC /TT0 1 Tf -0.002 Tc 0.002 Tw -30.75 -2.141 Td [(S)-8.9 (t)-17.5 (ag)-22.1 (i)-8.3 (ng)]TJ 0 Tc 0 Tw 3.446 0 Td ( )Tj 0.016 Tc -0.016 Tw 0.25 0 Td [(.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)]TJ 9.391 0 Td [(.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)]TJ 9.391 0 Td [(.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)]TJ 0 Tc 0 Tw 6.163 0 Td ( )Tj -0.007 Tc 0.007 Tw 0.261 0 Td (MS)Tj 0 Tc 0 Tw 1.5 0 Td (-)Tj EMC /Reference <>BDC 0.009 Tc -0.009 Tw 0.348 0 Td (30)Tj EMC /Span <>BDC /TT3 1 Tf 0 Tc 0 Tw ( )Tj EMC /TOCI <>BDC /TT0 1 Tf 0.009 Tc 0.007 Tw -30.75 -2.141 Td [(S)2.1 (ur)5 (g)-11.1 (i)2.8 (c)-1.9 (al)13.6 ( )0.5 (M)16 (anagem)5 (ent)]TJ 0 Tc 0 Tw 9.87 0 Td ( )Tj 0.016 Tc -0.016 Tw 0.283 0 Td [(.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.6 (.)0.5 (.)0.5 (.)0.5 (.)0.6 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!XVW÷ö÷˙ţ˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙KHID?A˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţ˙˙˙˙˙˙˙˙˙ţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙™äää˙˙˙˙˙˙ţţţţţţýýýFDE‚‚‚˙˙˙ţţţţţţţţţ˙˙˙ţţţţţţţţţţţţ˙˙˙ţţţţţţ˙˙˙ţţţţţţ˙˙˙ţţţ˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙ţţţţţţţţţýýýţţţţţţţţţýýýýýýţţţţţţţţţýýý˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙ţţţţţţ˙˙˙ţţţýýý˙˙˙{{{ [[[˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţ˙ţţý˙˙ü˙˙ý˙ëůôO±Ű!™Ö$ Ů$ˇŘ$¤×'ˇÚ' Ű%ˇÜ"˘Ý#˘Ü%ˇŰ' Ů'ˇ×#˘×¤Ř¤Ů%˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř( Ů' Ű#˘Ü$ŁŐ%ŁŇ'˘Ő$ˇŰ ˇßZ«Ęßű˙˙˙ţ˙üöű˙úů˙ýűţţţý˙˙ü˙ţ˙˙ţ˙˙ţ˙˙˙ýţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ËĘĘ 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–З͗ΗĎΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗÎÍ’Ć{ŻĹý˙˙˙˙ţ˙˙˙˙ýţţ˙˙ý˙˙ý˙˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ĚĘĘ523ńďđ˙˙˙ţţţţţţýýý˙˙˙˙˙˙„„ 312-)+C@@˙˙˙ţţţ˙˙˙Ŕľż ĎÍÎ˙˙˙ýýýţţţ˙˙˙˙˙˙ĂÁ®­­˙˙˙ţ˙˙˙˙˙˙˙˙źžž ččč˙˙˙˙˙˙˙˙˙˙˙˙ýüý;99 {{{˙˙˙ţýţ˙˙˙˝Ľ˝§¦¦˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙™——$!"ĎÎÎ˙˙˙ţţţ˙˙˙cab ‡‡‡˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙vuv lkl˙˙˙˙˙˙˙˙˙BAAGDE˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙WUU644˙˙˙˙˙˙ţţţ˙˙˙|{{ \\\˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙Y´×“É•Î!”ĐÍ—Í•Í •Î–ЖΖ͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖ÎĚv±Ăü˙˙˙˙˙ţţ˙ü˙ýţý˙˙ţţ˙˙ý˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ĚĘĘ523ńďđ˙˙˙ţţţţţţţţţţţţţ˙ţřřřdbc" C@@˙˙˙ţ˙˙˙˙˙ÇĹĆ‹‰Šđđđ˙˙˙˙˙˙éééźžź ¸¶¶˙˙˙ţ˙˙ţţţ˙˙˙ťś› żżżâââççç˙˙˙˙˙˙ýüý;99 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 0-.GDE}z{ßßß˙˙˙˙ţ˙ţ˙ţţţţţţţ˙˙˙˙˙˙ţţţ˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙ţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ýţţţţţţţţţţţ˙˙˙˙˙˙ţţţţţţţţţ˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙ţţţţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙ýţ˙ţ˙ţţţţţţ˙˙˙˙˙˙ţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ĎĎĎLKKUSS˙˙˙˙ţ˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙ţ˙˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙öööKKKRRRŰŰŰ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙VŞŐ‡ÂŚĂŤŔŚÄŤÂŤÁ‹ÄŤÂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂ…»q¨ľ˙˙˙˙˙ýý˙˙˙ţ˙˙˙˙ţ˙˙ţ˙˙˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙žťť=:;   $ 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'%&ĎÎĎ˙˙˙ţţţ˙˙˙ţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙ţţţýýýţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţýţţţţţ˙˙˙ţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ţţţ˙˙˙ţţţţţţţţţţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙ţţţţýţ˙ýţ˙˙˙ţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ĂĂĂ)'(˙˙˙˙˙˙ţţţţţţţţţţţţýýýţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţ˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ýýýţţţ˙˙˙ţţţ˙˙˙ýýý˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙öööJJJRRRÚÚÚ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙UŞÔ …ŔŠÁ‹żŠÂ‹Ŕ‹ż‰ÂŠŔŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠŔşp¨˝˙˙˙˙˙ýý˙˙˙ţ˙˙˙˙ţ˙˙ţ˙˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ŞŞŞ [XYÖÖÖ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙äă㌊Š trs˙˙˙ţţţ˙˙˙ţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ýýýţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţ˙˙ţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ýýý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţ˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţţţţ˙ţ˙˙˙˙˙˙˙ýýý˙˙˙ýýýţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ĂÂĂ)'(˙˙˙˙ţ˙ţţţ˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙ýýý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙üüü˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙üüüĐĐĐŃŃŃőőő˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙U©Ó ľż‰˝Á‰żŠľ‡Á‰żŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔż‚ąo§˝ţ˙˙˙˙ţý˙˙˙ţ˙˙˙˙ţ˙˙ţ˙˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ççç"""gde˙˙˙˙˙˙˙˙˙˙ýţ˙ţţ˙ýţ˙ţţ˙˙˙˙˙˙|z{˝˝˝˙˙˙ţţţýýý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙÷÷÷îîîűűű˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙řřřďďď˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ýýýďďďýýý˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙óóóňňň˙˙˙˙˙˙˙˙˙ýýý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ńđńůřůţţţţţţţţţ˙˙˙˙˙˙˙˙˙÷÷÷đđđ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ĂÂĂ)'(˙˙˙˙˙˙˙˙˙úúúđđđýýý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙÷ö÷îíî˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙řřřďďďüúű˙˙˙˙˙˙ţţţ˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙óňňńđđ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ďďď÷÷÷˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙T¨Ň 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x°w˛v±v¬w¨x¨r§iťł˙˙˙˙˙ţý˙˙˙ţ˙˙˙˙ţ˙˙ý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙MśĂr¬ w±x«w­ xŻ x°w­ xŻwŻ v° w¶ wł x« z© yŞ x´ vµ w˛ xŻ x­ xŻ x± vŻ y® y¬ y© xŞ x® w° x« w­ x°yłvµ u˛ y° z¬x«v­u­ w®xŻv­v¬v¬u¬v­w®y° wŻ y± x® x­ x¬x­vŻw˛ v± y±y® z¬ y« xŞxŞx«w¬ w­ xŻ x±z˛ x±wŻ v± u˛ xŻ zŞ y¦ yłv¶ x· yŻv° x± y® y«v« y° w±v°u« z­ x­x¬ w« x¬ x¬ yŻy± y˛ v˛ułv±qĄhť˛˙˙˙˙˙ţý˙˙˙ţ˙˙˙˙ţ˙˙ý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙ŢŢŢĐĐŃĐĎĐĐĐĐŐŐŐőőő˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙MśĂr¬ v° wŞv­ wŻ wŻv¬ w®u®u® wł x± yŞ w¦ x© x° w˛ v°u® vŻ x˛ u˛ w˛ wŻ x¬ y« y¬yŻy˛x´x± x± w± wµ w± w­y« x­ wµ w˛ w® w®v­u­w®u­ v® vŻ x± x° wŻv¬v«v«v­u° wł w± y°{­{°z°yŻ y® x­ x­ x® w­ xŻzŻ w­v®u° w° x« y¨uĄ y°wł włv® v´ w° w«w©u«yŻy˛ x˛ w­ y¨y°x´ v˛u±v® x­x­zŻ x± v´ v˛pĄhś˛˙˙˙˙˙ţý˙˙˙ţ˙˙˙˙ţ˙˙ý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙éééÄĂĂihhMMMKIJKIJUUUś›śÔÓÓ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙M›Âq« uŻ v© u« v­ v®u« v­ v® wŻp¦r©q¬s°r­sŞq§ v® u­tŞ t­ v± v±p« n¦ p§qŞr®tł nĄ t¬ v±t° w« w¨u¨rŞw±w´vŻr§mĄm§k¨l«k«n¬q¬t®vŻ u®t«tŞtŞu¬ v°w° v­ wŞrˇr«n©k¨k«k¬k¬jŞp¬r¬ v® v¬ v¬w´p©r¨t¬q´rŞ r¤ q¤ w˛ w®v¨t©s­ v±q¦r¨t¬s±p¨t§r¨v° t˛u˛t­u©u§u©t­uŻp¤gś±˙˙˙˙˙ţý˙˙˙ţ˙˙˙˙ţ˙˙ý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙úúú‡‡‡ )'(A@@655OMNćäĺ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙M›Âp© u® v© u« v­ v®u« u­w­ nže˘ľ„­Ŕj ¸b›łcśłpźµ]žĽ i™x® x« wŞv§m›^¨É}ŻČt˘şj™±h›±k¤şŤ°Â=Ť°s¨v¸ w§tŁt« t¶s¬o›C…˘mť´¬ŇăŮěóÝëďŢęěŰëîÇáě»Ď_“¬A„¤uŻ u« u« uŞ v¬y°v®p§ iž7‡°h—­©ĚÜÓëóßíđŕëěÜëîĚăŃ[´A…¦qźt©wŞ}«ĂŞ»hś°\ťľe›±uˇ´HŤ­t® vŞ v§ u­u´u¨yŞĹŞĽmźłcš¸ešµw¤ş‚´Ę3€Ą t§wŻ v° u­s©u© 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UUU˙˙˙˙ţţđď𛚛˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙K–ľhĄnŞpŁ mĄn§o¨oĄ n¦n©nĄ oťo¦0s’í˙˙¤żĎjˇ m¤o¦c•c«Ç˙˙˙˙ý˙ţţţ˙˙˙»Ĺ _ŹŞŐđâîňeťp p§m© m¦˙˙ú˙ýýţü˙˙˙˙ŠµĂbŽo n¦p­p˘pŁoĄo¨ n¤ nĄoĄq¤oŞp«dŚĎôóýţ˙ţýű˙˙˙ˇÉŢdˇ nŁ oˇoĄpŞp¨ m¦n§oĄ nˇs  n¦ lŞ l© n§r kťP™Ä˙˙ýw«oĄpĄmˇ mť«ÍÖ˙˙˙˙ü˙˙ü˙÷˙ýf¤Ŕ/x©ţ˙˙®Ń×`Źq¦p¤p¤o¤o¤o¤oĄo¦o§o¦hśe—­˙˙˙˙ţţü˙˙˙˙˙˙˙˙ţ˙˙ţ˙˙˙ţ˙˙˙˙ţţţţţţţţţüüüLJK@==˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ýýý˙˙˙ěěě˙˙˙˙˙˙˙˙˙ HGGkjkÁżŔĐĐĐĐĐĐŇŃŇ"  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ZŽ[‘[\’\“[”^•d—jˇk jťhťkĄj˘h¤h˘q›_–j i i i i i i i i i iźb—c”Ş˙˙˙˙ţţü˙˙˙ţ˙˙ţ˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙ţţţţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙ţţţţţţţţţ˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙I’¸d›jźiťiˇiˇižk›h jžj i¨iĄhźh f¤h¤hźhźiźiťjškˇk˘h g iˇežh kžikˇkĄkźiźi˘iŁl¤iŁ fŁeĄi¨ežbś`śaścťd g¤gťlśk k©j¦i¤h hžiťiťi hˇf˘f¤c cš_žažhźjšf¤h¤h¤h¤jś bśeŁh§gˇjĄh¦gŁiśjźkžjť gžkŁiťjŁgŁfšfśiźiźiźiźiźiźiźiźiźiźižb—d”Ş˙˙˙˙˙ţü˙˙˙ţ˙˙ţ˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţ˙˙ţ˙ţ˙˙˙ţţţýýý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţţţţ˙˙˙ţţţýýý˙˙˙ţţţ˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţ˙˙˙ţţţ˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙I‘¸cšiźiťhˇh hžj›gźhťgś fˇhźhťižhžiśiˇhťhśh  f˘h hžiśhťh˘gŁfˇjśh˘hš g™ eŁgĄh›ik›l”fťhźgśkť g›e˘gĄjźk–ižj˘hźfźhˇ gť f›k k™ižiźfg¤iŁh›h–hžiźhˇf g h•g™gśh›hži i˘jŁhškśhźg jži gžgźhˇgž f–i›kˇfźj gžhźhźhźhźhźhźhźhźhźhža–b”Ş˙˙˙˙ţýü˙˙˙ţ˙˙ţ˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙ţ˙ţýţţţ˙˙ţţţ˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙ţţţ˙˙˙˙˙˙ţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙H¸`šfžjśf fźgťh›h gźgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgťgžgžgžgźgžgžgžgžgžgžgťgžgźgžgžgžgžgžgžgžgžgžgžgžgžgťgžgžgźgžgžgžgžgžgźgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgźgžgžgžgžgžgžgžgžgžgžgžgžgžgžgž_”b’¨˙˙˙˙ţţü˙˙˙ţ˙˙ţ˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţýýýţţţ˙ţţţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙ţýţţýţ˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţýýý˙˙˙ţţţ˙˙˙˙ţ˙˙ţ˙ţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţţţţýýýţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙H¸`šfžjśf fźgťh›h gźgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgž_”b’¨˙˙˙˙ţýü˙˙˙ţ˙˙ţ˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ýýý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ýýý˙˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţýýýţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ýýý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙H¸`šgžiśf fźgťh›h hźhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhť_”b’¨˙˙˙˙ţýü˙˙˙ţ˙˙ţ˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙÷÷÷ŰŰŰÚÚÚóóó˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţýýăââÜŰÜăââ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙ţţţćĺćÚŮŮŕßŕţţţ˙˙˙ýýýţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙ęęęŔŔŔľľľŇŇŇ˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙H¸`šfži›fźfźgťh›h gźgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgť_”b’¨˙˙˙˙ţýü˙˙˙ţ˙˙ţ˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ŰŰŰbbb_^_Ş©©˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙ţţ„‚‚cac€}~˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ýýý˙˙˙˙˙˙’‘’a_`xvw˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙ŕŕ੩ŠvvvzzzuuuÂÂÂ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙HŹ¸`™eťhšežežfśgšfźfžfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfť^“b’¨˙˙˙˙ţţü˙˙˙ţ˙˙ţ˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ÉÉÉÇĹĆ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙FCD>;<˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ł˛˛===MMMëëë˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙XXX0//˙˙˙ţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙¬¬¬YYYşşşÉÉÉÍÍÍÁÁÁ€€€bbbööö˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙GŹ·_eťhšeždťe›f™fžeťeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeś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™—˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙ĹÄĹ!¦¦¦˙˙˙˙˙˙˙˙˙ŹŤŤ‹‰Š˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙^\]867˙˙˙˙˙˙˙˙˙ŐŐŐ#!"JJJ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţýůüţţüýţ˙˙˙ńőň;‚¨R„_’b a’a”a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–`—a—b™b–`’_‘`“TŚ<Ąčůú˙˙ţţý˙ú˙ýú˙ýüýţ˙ý˙˙ý˙ý˙˙ţ˙ű˙˙ů˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ĚĘĘ523ńďđ˙˙˙˙˙˙ţţţ˙˙˙ţţţ˙˙˙  C?A˙˙˙˙ţ˙˙ţţ˙˙˙€€:89ęęę˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙}~!úúúţţţţţţ˙˙˙źžž 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(er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 740.28 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 756.84 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 760.56 23.76 Tm (2)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /H1 <>BDC /TT1 1 Tf 0.009 Tc -0.009 Tw 12.96 -0 0 12.96 23.52 513.72 Tm [(O)-9.3 (v)18.7 (er)-9.4 (v)9.4 (iew)]TJ 0 Tc 0 Tw 4.519 0 Td ( )Tj EMC /H2 <>BDC 0.009 Tc -0.009 Tw 11.04 -0 0 11.04 23.52 494.64 Tm [(E)2.1 (pi)-6.4 (de)10.6 (m)6.8 (i)-6.5 (ol)4.4 (og)0.5 (y)]TJ 0 Tc 0 Tw 6.63 0 Td ( )Tj 0.293 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw -6.924 -1.696 Td [(T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d nodul)2.6 (es)-2 ( a)10.5 (r)-5.9 (e app)10.5 (r)4.9 (ox)8.9 (i)2.6 (m)-6 (at)-6.6 (el)2.6 (y)8.9 ( 4 t)-6.7 (i)2.6 (m)-5.9 (es)-2 ( )11.2 (m)-5.9 (o)10.5 (r)-6 (e c)8.9 (om)-5.9 (m)-6 (on)10.6 ( i)2.6 (n w)13.5 (om)-6 (en )11.3 (t)-6.6 (han )]TJ 0 -1.38 Td [(i)2.6 (n m)-6 (en.)4.3 ( )]TJ [(P)1.9 (al)2.6 (pabl)2.7 (e nodul)2.6 (es)-2 ( i)2.6 (nc)-2 (r)-5.9 (eas)-2 (e)10.5 ( i)2.6 (n )11.2 (f)-6.6 (r)-5.9 (e)10.5 (q)-11.2 (uenc)-2 (y)8.9 ( t)4.3 (hr)-5.9 (ou)10.6 (g)-11.3 (hout)4.3 ( l)2.7 (i)2.6 (f)-17.5 (e)10.5 (,)4.3 ( r)-6 (eac)-2 (hi)2.6 (n)10.5 (g)-11.2 ( )11.3 (a )]TJ 0 -1.37 Td [(pr)-6 (ev)8.9 (al)2.6 (enc)-2 (e o)10.6 (f)-17.5 ( abou)10.6 (t)-6.6 ( 5)10.6 (%)-4.3 ( i)13.5 (n t)-6.6 (he)10.6 ( U)2.6 (.)-6.6 (S)1.9 (.)4.3 ( popul)2.6 (at)-6.7 (i)2.7 (on )]TJ -0.004 Tw 20.554 0 Td [(f)-6.6 (or)5 ( i)2.6 (ndi)-8.2 (v)8.8 (i)2.7 (dual)2.6 (s)-2 ( )]TJ 0.002 Tw 6.359 0 Td [(ag)-11.3 (e)]TJ 0 Tc 0 Tw (d)Tj 2.228 0 Td ( )Tj -0.013 Tc 0.013 Tw 0.283 0 Td [(5)-11.3 (0 )]TJ -0.002 Tc 0.007 Tw -29.424 -1.38 Td [(y)8.9 (ear)-6 (s)-2 ( and ol)2.6 (der)]TJ 0 Tc 0 Tw 6.87 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(hav)8.9 (i)2.6 (ng)-11.2 ( p)10.5 (al)2.6 (pabl)2.6 (e t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d nodul)2.6 (es)-2 (.)]TJ 0 Tc 0 Tw 6.96 -0 0 6.96 260.28 434.28 Tm (1)Tj 0.552 0 Td (-)Tj 0.328 0 Td (3)Tj 11.04 -0 0 11.04 270.24 430.32 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(N)2.6 (odul)2.6 (es)]TJ 0 Tc 0 Tw 3.652 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(ar)-6 (e )0.5 (ev)8.9 (en )]TJ -26.565 -1.37 Td [(m)-6 (or)-6 (e)10.6 ( pr)-6 (ev)8.9 (al)2.7 (ent)-6.6 ( w)13.5 (hen t)-6.6 (he)10.5 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )11.3 (g)-11.2 (l)2.6 (and i)2.6 (s)-2 ( ex)8.9 (am)-5.9 (i)2.6 (ne)10.5 (d )]TJ [(at)4.3 ( aut)-6.6 (ops)-2 (y)8.9 ( o)10.5 (r)-6 ( s)-2 (u)10.6 (r)4.9 (g)-11.2 (er)-5.9 (y)8.8 (,)-6.6 ( )]TJ 0 -1.38 Td [(or)-6 ( w)13.5 (hen us)-2 (i)2.6 (ng ul)2.7 (t)-6.6 (r)-6 (a)10.5 (s)-2 (ono)10.5 (g)-11.2 (r)4.9 (aphy)8.9 (;)-6.6 ( 50%)6.5 ( o)10.6 (f)-6.6 ( t)-6.6 (he)10.5 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (ds)-2 ( )0.5 (s)-2.1 (t)-6.6 (udi)2.7 (ed)10.5 ( hav)8.9 (e nodul)2.6 (es)-2 (,)4.3 ( )]TJ 0 -1.37 Td [(w)13.5 (h)-11.2 (i)2.6 (c)-2 (h ar)-6 (e)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 4.554 0 Td [(al)2.6 (m)-6 (o)10.5 (s)-2 (t)4.3 ( al)2.7 (w)13.4 (a)-11.2 (y)8.9 (s)-2 ( beni)2.6 (g)-11.3 (n.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 182.04 388.8 Tm [(2,)-1.9 (4)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 191.64 384.84 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(N)2.6 (ew)13.4 ( nodul)2.7 (es)]TJ 0 Tc 0 Tw 5.75 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(dev)8.9 (el)2.7 (op at)-6.6 ( a r)-5.9 (a)10.5 (t)-6.6 (e)10.5 ( o)10.5 (f)-6.6 ( about)4.3 ( )]TJ -21.543 -1.38 Td [(0.)-6.7 (1%)6.6 ( per)4.9 ( y)8.9 (ear)-6 (,)-6.6 ( be)10.6 (g)-11.3 (i)2.7 (nni)2.6 (n)10.5 (g )0.5 (i)2.5 (n ear)-5.9 (l)2.6 (y)8.8 ( l)2.6 (i)2.6 (f)-17.4 (e)10.5 (,)-6.6 ( bu)10.6 (t)-6.7 ( )11.3 (t)-6.6 (hey)8.9 ( dev)8.9 (el)2.6 (op at)-6.6 ( a)10.5 ( m)-6 (u)10.6 (c)-2 (h hi)13.4 (g)-11.2 (her)5 ( )]TJ 0 -1.37 Td [(r)-6 (at)-6.6 (e)10.5 ( \()-5.9 (app)10.5 (r)-6 (ox)8.9 (i)2.6 (m)-6 (at)-6.6 (el)2.6 (y)8.9 ( 2%)-4.3 ( p)10.5 (er)-6 ( y)8.9 (ear)-5.9 (\))4.9 ( a)10.5 (f)-6.6 (t)-6.6 (er)5 ( ex)8.9 (pos)-2 (ur)-5.9 (e )11.3 (t)4.3 (o head and)10.5 ( nec)8.9 (k)-2 ( )]TJ 0.002 Tw 0 -1.38 Td [(i)2.6 (r)-6 (r)-5.9 (adi)2.6 (at)-6.6 (i)2.6 (on.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 75 343.2 Tm [(5,)-1.9 (6)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 84.6 339.24 Tm ( )Tj EMC /P <>BDC -0.011 Tc 0.016 Tw -5.533 -2.37 Td [(B)-7.1 (y c)-11 (o)]TJ -0.002 Tc 0.007 Tw 2.489 0 Td [(nt)-6.7 (r)-5.9 (as)-2 (t)4.3 (,)4.3 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a i)2.6 (s)8.9 ( unc)-2 (om)5 (m)-6 (on)10.5 (.)-6.6 ( Fo)10.5 (r)-5.9 ( )11.2 (t)-6.6 (he U)2.6 (.)-6.6 (S)12.8 (.)-6.6 ( popul)2.6 (a)10.6 (t)-6.6 (i)2.6 (on,)-6.6 ( )11.2 (t)-6.6 (he )]TJ -0.005 Tc 0.005 Tw -2.489 -1.37 Td [(lif)-20.5 (e)-3.3 (t)-9.6 (i)10.4 (m)-8.9 (e)-3.4 ( )]TJ -0.011 Tc 0.011 Tw 3.435 0 Td [(r)-15 (i)-6.3 (sk)-21.9 ( )]TJ -0.002 Tc 0.007 Tw 1.837 0 Td [(o)10.5 (f)-6.6 ( bei)2.6 (n)10.5 (g)-11.2 ( di)2.6 (a)10.5 (gnos)-2 (ed w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (n)10.5 (om)-6 (a i)2.6 (s)8.8 ( )0.5 (1)]TJ 0.005 Tc -0.005 Tw (.2)Tj 0.002 Tc -0.002 Tw 21.261 0 Td (%.)Tj 0 Tc 0 Tw 6.96 -0 0 6.96 329.4 301.92 Tm (7)Tj 11.04 -0 0 11.04 333.24 297.96 Tm ( )Tj -0.006 Tc 0.011 Tw 0.272 0 Td [(I)-10.6 (t i)-1.4 (s)]TJ 0 Tc 0 Tw 1.554 0 Td ( )Tj -0.002 Tc -0.004 Tw -29.88 -1.38 Td [(es)-2 (t)-6.7 (i)2.7 (m)-6 (a)10.5 (t)-6.6 (ed t)-6.6 (hat)4.2 ( )-10.6 (appr)-6 (ox)8.9 (i)2.6 (m)4.9 (at)-6.6 (el)2.6 (y)8.9 ( )]TJ 0.002 Tw 13.011 0 Td [(53,)-6.6 (990)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc -0.004 Tw 3.337 0 Td [(new)13.5 ( )-10.6 (c)-2 (as)-2 (es)-2 ( o)10.5 (f)-17.5 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (a )]TJ -0.005 Tc 0.005 Tw 14.239 0 Td [(w)10.5 (ill )]TJ -0.002 Tc 0.002 Tw -30.587 -1.37 Td (be)Tj 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 1.391 0 Td [(di)2.6 (ag)-11.2 (nos)-2 (ed)10.5 ( i)2.6 (n )11.3 (t)-6.6 (he U)2.6 (ni)2.6 (t)4.2 (ed S)2 (t)-6.6 (at)4.3 (es)-2 ( i)2.6 (n )]TJ 0.002 Tw (2018)Tj 0 Tc 0 Tw 17.12 0 Td (.)Tj 6.96 -0 0 6.96 231 271.56 Tm (8)Tj 11.04 -0 0 11.04 234.84 267.6 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 (s)8.8 ( w)13.5 (i)-8.2 (t)-6.7 (h )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d nodul)2.7 (es)-2 (,)-6.6 ( )]TJ -19.424 -1.38 Td [(t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)]TJ 5.163 0 Td [(i)2.6 (nom)4.9 (a oc)-2 (c)-2 (u)10.5 (r)-5.9 (s)8.9 ( 2 )11.3 (t)-6.6 (o 3)10.6 ( t)-6.6 (i)2.6 (m)5 (es)-2 ( )11.3 (m)-6 (or)-6 (e)10.6 ( o)10.5 (f)-6.6 (t)-6.7 (en)10.5 ( i)2.6 (n w)13.5 (om)-5.9 (en t)-6.6 (han)10.5 ( i)2.6 (n m)-5.9 (e)10.5 (n.)]TJ 0 Tc 0 Tw 26.685 0 Td ( )Tj -31.848 -1.37 Td (T)Tj -0.002 Tc 0.007 Tw 0.62 0 Td [(hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (ar)4.9 (c)-2 (i)2.7 (nom)-6 (a)10.5 ( i)2.6 (s)-2 ( c)-2 (ur)4.9 (r)-6 (ent)-6.7 (l)2.7 (y)8.8 ( t)-6.6 (he )]TJ 0.005 Tc -0.005 Tw 14.62 0 Td [(fi)20.5 (fth)]TJ 0 Tc 0 Tw 1.609 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.272 0 Td [(m)-6 (os)8.9 (t)-6.6 ( )-10.6 (c)-2 (o)10.5 (m)4.9 (m)-6 (on m)-5.9 (al)2.6 (i)2.6 (g)-11.2 (nanc)-2 (y)8.8 ( )]TJ 0.007 Tw -17.12 -1.38 Td [(di)2.6 (ag)-11.2 (nos)-2 (ed i)2.6 (n)10.6 ( w)13.5 (om)-6 (en.)]TJ 0 Tc 0 Tw 6.96 -0 0 6.96 127.56 225.96 Tm (8)Tj 11.04 -0 0 11.04 131.4 222 Tm ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(The di)2.6 (s)-2 (eas)-2 (e i)2.6 (s)-2 ( al)2.6 (s)-2 (o)10.5 ( di)2.6 (ag)-11.2 (n)10.5 (os)-2 (ed m)-6 (o)10.6 (r)-6 (e o)10.5 (f)-6.6 (t)-6.6 (e)10.5 (n i)2.6 (n w)13.5 (hi)2.6 (t)-6.6 (e )]TJ -10.043 -1.37 Td [(N)2.6 (or)-6 (t)-6.6 (h A)12.8 (m)-6 (er)-6 (i)2.6 (c)-2 (ans)8.9 ( t)-6.6 (han)10.5 ( i)2.6 (n )11.3 (A)1.9 (f)-6.6 (r)-6 (i)2.7 (c)-2 (an A)12.9 (m)-6 (er)]TJ 0.002 Tw 16.739 0 Td [(i)2.6 (c)-2 (ans)8.9 (.)-6.6 ( )]TJ -0.004 Tw 2.87 0 Td [(T)-10.6 (he)10.5 ( m)-6 (ai)2.6 (n )-10.6 (hi)2.6 (s)-2 (t)-6.6 (ol)2.7 (o)10.5 (g)-11.2 (i)2.6 (c)-2 ( t)-6.6 (y)8.9 (pes)-2 ( )-10.6 (o)10.5 (f)-6.6 ( )]TJ 0.007 Tw -19.609 -1.38 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a )0.5 (a)10.5 (r)-6 (e:)4.2 ( 1\))4.9 ( di)13.5 (f)-6.6 (f)-17.5 (e)10.6 (r)-6 (ent)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( \()-5.9 (i)2.6 (nc)-2 (l)2.7 (udi)2.6 (n)10.5 (g)-11.2 ( )11.2 (papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 (,)-6.6 ( f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.7 (ar)-5.9 (,)-6.7 ( an)10.5 (d )]TJ 0 -1.37 Td [(H)2.6 -6 (t)-6.6 (hl)2.6 (e c)-2 (el)2.6 (l)2.6 (\))-6 (;)4.3 ( 2\))5 ( )11.2 (m)-5.9 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 (;)-6.6 ( and 3\))4.9 ( anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)8.9 (,)-6.6 ( w)13.4 (hi)2.6 (c)-2 (h i)2.6 (s)-2 ( an)10.5 ( a)10.6 (gg)-11.2 (r)-6 (es)-2 (s)-2 (i)2.6 (v)8.9 (e )]TJ -0.004 Tw 0 -1.38 Td [(undi)2.6 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( )-10.6 (t)-6.6 (u)10.6 (m)-6 (or)4.9 (.)-6.6 ( O)4.3 (f)-6.6 ( )]TJ 0.002 Tw 11.587 0 Td [(63)10.5 (,)-6.6 (324)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.002 Tw 3.326 0 Td [(pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)]TJ 0 Tc 0 Tw 3.478 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(di)2.6 (ag)-11.2 (no)10.6 (s)-2 (ed w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0.002 Tw -18.674 -1.37 Td [(c)-2 (ar)-6 (c)]TJ 0.007 Tw 1.891 0 Td [(i)2.6 (nom)-5.9 (a)10.5 ( )11.2 (f)-6.6 (r)-5.9 (om)5 ( 2011 )11.2 (t)-6.6 (o)10.6 ( )11.2 (2015,)-6.6 ( 89)10.5 (.)-6.6 (8%)6.6 ( had papi)2.6 (l)2.6 (l)2.6 (ar)4.9 (y)8.9 ( c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a,)4.2 ( )0.5 (4.)-6.6 (5)10.5 (%)-4.3 ( ha)10.5 (d )]TJ -1.891 -1.38 Td [(f)-6.6 (ol)2.7 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (,)-6.6 ( 1)10.5 (.)-6.6 (8)10.6 (%)-4.4 ( had)10.6 ( H)2.6 -5.9 (t)-6.6 (hl)2.6 (e)10.6 ( c)-2 (el)2.6 (l)2.6 ( c)-2 (ar)-6 (c)-2 (i)2.6 (n)10.6 (om)-6 (a,)4.3 ( 1.)-6.6 (6)]TJ 0.002 Tc -0.002 Tw 25.37 0 Td (% )Tj -0.002 Tc -0.004 Tw 1.174 0 Td [(had)10.5 ( m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( )]TJ 0.007 Tw -26.543 -1.37 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (,)-6.6 ( and)10.5 ( 0.)-6.6 (8)]TJ 8.478 0 Td [(%)-4.3 ( ha)10.5 (d )]TJ [(anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-6 (a)]TJ 0 Tc 0 Tw 12.467 0 Td (.)Tj 6.96 -0 0 6.96 257.88 119.76 Tm (7)Tj 11.04 -0 0 11.04 261.72 115.8 Tm ( )Tj 0.272 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -21.848 -2.37 Td [(M)15.8 (or)-5.9 (t)-6.6 (al)2.6 (i)2.7 (t)-6.7 (y)8.9 ( r)-6 (at)-6.6 (es)-1.9 ( )11.2 (f)-17.5 (o)10.6 (r)-6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (a a)10.5 (r)-5.9 (e,)4.3 ( i)2.6 (n )11.2 (g)-11.2 (ener)4.9 (al)2.6 (,)-6.6 ( v)8.9 (er)-6 (y)8.9 ( l)2.6 (o)-11.2 (w)13.4 (.)-6.6 ( )]TJ -0.004 Tw 0 -1.38 Td [(D)2.6 (i)2.6 (f)-6.6 (f)-6.6 (er)-6 (en)10.6 (t)-6.6 (i)2.6 (at)-6.6 (ed t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0.002 Tw 9.478 0 Td [(c)-2 (ar)4.9 (c)-2 (i)2.6 (nom)-6 (as)-2 ( )]TJ 0.007 Tw 5.38 0 Td [(us)-2 (ual)2.6 (l)2.6 (y)8.9 ( hav)8.9 (e an ex)8.9 (c)-2 (el)2.7 (l)2.6 (ent)-6.6 ( pr)-5.9 (o)10.5 (g)-11.2 (nos)]TJ -0.005 Tc 0.01 Tw 15.011 0 Td [(is)-5 ( w)10.5 (it)-9.6 (h)-3.4 ( )]TJ -0.002 Tc 0.002 Tw -29.87 -1.37 Td (10)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 1.446 0 Td [(y)8.9 (ear)-6 ( s)-2 (ur)-6 (v)8.9 (i)2.6 (v)8.9 (al)2.6 ( r)-5.9 (at)-6.6 (es)-2 ( ex)8.9 (c)-2 (eedi)2.6 (ng)-11.2 ( 90)10.5 (%)-4.3 ( )11.2 (t)-6.6 (o)10.6 ( 95%)6.5 (.)]TJ 0 Tc 0 Tw 6.96 -0 0 6.96 247.44 63.24 Tm (9)Tj 11.04 -0 0 11.04 251.28 59.28 Tm ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(I)-6.6 (n)10.5 ( )-10.6 (c)-2 (ont)4.3 (r)-6 (as)-2 (t)4.2 (,)-6.6 ( anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( )]TJ 0.007 Tw -20.913 -1.38 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a )0.5 (i)2.6 (s)-2 ( al)13.5 (m)4.9 (os)-2 (t)-6.7 ( uni)13.4 (f)-17.5 (o)10.6 (r)4.9 (m)-6 (l)2.6 (y)8.9 ( l)2.6 (et)-6.6 (hal)2.6 (.)-6.6 ( H)]TJ 0.002 Tw 20.326 0 Td [(ow)2.6 (ev)8.9 (er)-5.9 (,)-6.6 ( )]TJ 0.007 Tw 3.772 0 Td [(s)-2 (i)2.6 (nc)-2 (e di)13.4 (f)-6.6 (f)-6.6 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( )]TJ 10.457 42.565 Td [(t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (as)-2 ( )11.2 (r)-5.9 (epr)-6 (e)10.5 (s)-2 (ent)-6.5 ( )11.2 (m)-6 (or)-5.9 (e)10.5 ( t)-6.6 (han)10.5 ( 95)10.6 (%)-4.3 ( o)10.5 (f)-6.6 ( al)13.5 (l)2.6 ( c)-2 (as)-2 (es)-2 (,)4.3 ( )]TJ [(m)-6 (o)10.5 (s)-2 (t)4.3 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0.002 Tw 0 -1.38 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)]TJ 0 Tc 0 Tw 4.598 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(deat)-6.7 (hs)8.9 ( )-10.6 (ar)-5.9 (e)10.5 ( f)-6.6 (r)-6 (o)10.5 (m)-5.9 ( )-10.7 (papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 (,)-6.6 ( f)-17.5 (ol)2.6 (l)2.7 (i)2.6 (c)-2 (ul)2.6 (ar)-6 (,)]TJ 0 Tc 0 Tw 15.446 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(an)10.5 (d H)2.6 -6 (t)-6.6 (hl)2.6 (e)10.5 ( c)-2 (el)2.6 (l)2.6 ( )]TJ 0.002 Tw -20.609 -1.37 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)]TJ -0.011 Tc 0.011 Tw [(s.)-15.6 ( )]TJ -0.002 Tc 0.002 Tw 5.652 0 Td [(I)-6.6 (n )]TJ 1.12 0 Td (2018)Tj -0.006 Tc 0.006 Tw 2.207 0 Td (, )Tj 0.005 Tc 0 Tw 0.554 0 Td [(i)9.6 (t i)9.6 (s)15.9 ( e)6.6 (s)5 (ti)20.5 (m)1.1 (a)6.6 (te)6.7 (d)17.5 ( th)6.7 (a)17.5 (t )]TJ -0.002 Tc 0.002 Tw [(app)10.5 (r)-5.9 (ox)8.9 (i)2.6 (m)-6 (at)-6.6 (el)2.6 (y)8.9 ( )]TJ 14.783 0 Td (2060)Tj 0 Tc 0 Tw ( )Tj -0.002 Tc 0.002 Tw 2.5 0 Td [(c)-2 (anc)-2 (er)4.9 ( )]TJ -26.815 -1.38 Td [(deat)-6.7 (hs)-2 ( )]TJ -0.005 Tc 0.005 Tw 3.283 0 Td [(w)10.5 (ill )]TJ -0.002 Tc 0.007 Tw 1.641 0 Td [(oc)-2 (c)-2 (ur)-5.9 ( a)10.5 (m)-6 (on)10.5 (g)-11.2 ( )11.2 (per)-5.9 (s)-2 (ons)-2 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (hy)8.9 (r)-6 (oi)2.5 (d c)-2 (a)10.5 (r)-5.9 (c)8.8 (i)2.7 (nom)-6 (a i)2.6 (n )11.3 (t)-6.6 (he U)2.6 (ni)2.6 (t)-6.6 (ed)10.5 ( )]TJ 0.002 Tw -4.924 -1.37 Td [(S)2 (t)-6.7 (at)-6.6 (es)]TJ 0 Tc 0 Tw 2.826 0 Td (.)Tj 6.96 -0 0 6.96 439.32 457.2 Tm (8)Tj 11.04 -0 0 11.04 443.16 453.24 Tm ( )Tj 0.272 0 Td (T)Tj -0.002 Tc 0.007 Tw 0.62 0 Td [(hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (no)10.6 (m)-6 (a oc)8.9 (c)-2 (ur)-5.9 (s)8.8 ( m)-5.9 (o)10.5 (r)-5.9 (e o)10.5 (f)-6.6 (t)-6.6 (en)10.5 ( i)2.6 (n )11.3 (w)13.5 (om)-6 (en)]TJ [(;)-6.6 ( how)13.5 (ev)8.9 (er)]TJ 0.005 Tc -0.005 Tw 24.685 0 Td (, )Tj -0.005 Tc 0.005 Tw -29.033 -1.38 Td [(m)-9 (o)-3.3 (r)1.9 (t)-9.6 (a)-3.4 (lit)-9.6 (y)]TJ 0 Tc 0 Tw 3.761 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(r)-6 (at)-6.6 (es)8.9 ( ar)-6 (e)10.5 ( )]TJ 0.002 Tw [(l)2.6 (ow)13.5 (er)]TJ 0 Tc 0 Tw 6.587 0 Td ( )Tj -0.007 Tc 0.007 Tw 0.283 0 Td [(f)-11.6 (o)-5.4 (r )]TJ -0.002 Tc 1.446 0 Td [(y)8.9 (oung)-11.2 (er)4.9 ( w)13.4 (o)]TJ 0.002 Tw [(m)-6 (en)]TJ 0 Tc 0 Tw (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 622.8 441.96 Tm [(7,)-1.9 (10)]TJ 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 2.276 0 Td (12)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 646.44 438 Tm ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(A)2 (l)2.6 (t)-6.6 (hou)10.5 (g)-11.2 (h t)-6.6 (he )-10.6 (es)8.9 (t)-6.6 (i)2.6 (m)-6 (a)10.6 (t)-6.6 (ed )]TJ 0.007 Tw -22.152 -1.37 Td [(i)2.6 (nc)-2 (i)2.6 (denc)-2 (e o)10.5 (f)-17.5 ( )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)13.4 (nom)-5.9 (a )]TJ 13.75 0 Td [(p)10.5 (r)-5.9 (ev)8.9 (i)2.6 (ous)-2 (l)-8.3 (y)8.9 ( i)2.6 (nc)-2 (r)-6 (eas)8.9 (ed by)8.8 ( an av)8.8 (er)-6 (a)10.6 (g)-11.3 (e o)10.5 (f)-6.6 ( )11.3 (~)-5 (5%)6.6 ( )]TJ -13.75 -1.38 Td [(annual)2.6 (l)2.6 (y)8.8 ( bet)-17.5 (w)13.5 (een 2004 a)10.5 (nd 2013)]TJ [(,)4.2 ( t)-6.6 (he)10.5 ( i)2.6 (nc)-1.9 (i)2.6 (denc)-2 (e )]TJ [(r)4.9 (at)-6.6 (e has)8.9 ( r)-5.9 (ec)-2 (en)10.5 (t)-6.6 (l)2.6 (y)8.9 ( )]TJ 0 -1.37 Td [(s)-2 (t)-6.6 (abi)2.6 (l)2.6 (i)2.6 (z)8.9 (ed,)-6.6 ( l)2.6 (i)2.6 (k)-12.9 (el)2.6 (y)8.9 ( due t)-6.6 (o )11.2 (m)4.9 (or)-6 (e c)-2 (ons)-2 (e)10.5 (r)-5.9 (v)8.9 (at)-6.6 (i)2.6 (v)8.9 (e i)2.6 (ndi)2.6 (c)-1.9 (at)-6.6 (i)2.6 (ons)-2 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )]TJ 25.087 0 Td [(t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d bi)2.6 (ops)-1.9 (y)]TJ 0 Tc 0 Tw 6.141 0 Td ( )Tj -0.002 Tc 0.007 Tw -31.228 -1.38 Td [(and t)-6.7 (he)10.5 ( r)-5.9 (ec)-2 (l)2.6 (as)-2 (s)-2 (i)13.5 (f)-17.5 (i)2.6 (c)-2 (a)10.5 (t)-6.6 (i)2.6 (on o)10.6 (f)-6.7 ( noni)2.6 (nv)8.8 (as)-2 (i)2.6 (v)8.9 (e f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( t)-6.6 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d neopl)2.6 (as)-2 (m)-6 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ 0.002 Tw 0 -1.37 Td [(papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)]TJ 0 Tc 0 Tw 3.696 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(l)-8.3 (i)2.6 (k)-12.8 (e )-10.6 (nuc)-2 (l)2.6 (ear)5 ( f)-17.5 (ea)10.5 (t)4.3 (ur)-5.9 (es)-2 ( \()-6 (N)2.7 (I)-6.7 (F)11.2 (T)-10.5 (P)1.9 (\))]TJ 0 Tc 0 Tw 12.75 0 Td (.)Tj 6.96 -0 0 6.96 593.4 366.12 Tm (8)Tj 11.04 -0 0 11.04 597.24 362.16 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(B)2 (ec)-2 (aus)-2 (e)10.6 ( )11.2 (ov)8.8 (er)-6 (al)2.6 (l)2.6 ( m)-6 (or)-6 (t)-6.6 (al)2.6 (i)2.6 (t)-6.6 (y)8.9 ( has)-2 ( no)10.6 (t)-6.7 ( )]TJ -17.696 -1.38 Td [(dr)-6 (am)-5.9 (a)10.5 (t)-6.6 (i)2.6 (c)-2 (al)2.6 (l)2.6 (y)8.9 ( i)2.6 (nc)-2 (r)-5.9 (eas)-2 (ed s)-2 (i)2.6 (nc)-2.1 (e 1975 )11.3 (\()-6 (1150 v)8.9 (s)-2 (.)4.3 ( 2060)10.5 ( deat)-6.6 (hs)8.8 (\))-5.9 (,)4.2 ( t)-6.6 (he)10.5 ( pr)-5.9 (ev)8.9 (i)2.6 (ous)-2 ( )]TJ 0 -1.37 Td [(i)2.6 (nc)-2 (r)-6 (eas)-2 (e i)2.6 (n i)2.6 (nc)-2 (i)2.6 (denc)-2 (e )11.3 (m)-6 (a)10.6 (y)8.8 ( r)-6 (e)10.6 (f)-17.5 (l)2.6 (ec)-2 (t)4.2 (,)-6.6 ( a)10.6 (t)-6.7 ( l)2.7 (eas)8.9 (t)-6.6 ( i)2.6 (n )]TJ [(pa)10.5 (r)-5.9 (t)4.2 (,)-6.6 ( )11.3 (ear)-5.9 (l)2.6 (i)2.6 (er)-5.9 ( det)-6.6 (e)10.5 (c)-2 (t)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( )]TJ 0 -1.38 Td [(s)-2 (ubc)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.7 ( di)2.6 (s)-2 (eas)-2 (e \()-6 (i)2.6 (e,)-6.6 ( )11.2 (s)8.9 (m)-5.9 (al)2.6 (l)2.6 ( )]TJ [(papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.6 (s)-2 (\))-6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 653.88 320.52 Tm (13)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 1.431 0 Td (18)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 671.52 316.56 Tm ( )Tj 0.009 Tc -0.009 Tw 0.283 0 Td [(H)13.6 (ow)24.5 (ev)19.8 (e)10.7 (r)5 (,)]TJ 0 Tc 0 Tw 4.217 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(dat)-6.6 (a)10.5 ( )]TJ 0.007 Tw 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!XVW÷ö÷˙ţ˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙KHID?A˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţ˙˙˙˙˙˙˙˙˙ţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙™äää˙˙˙˙˙˙ţţţţţţýýýFDE‚‚‚˙˙˙ţţţţţţţţţ˙˙˙ţţţţţţţţţţţţ˙˙˙ţţţţţţ˙˙˙ţţţţţţ˙˙˙ţţţ˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙ţţţţţţţţţýýýţţţţţţţţţýýýýýýţţţţţţţţţýýý˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙ţţţţţţ˙˙˙ţţţýýý˙˙˙{{{ [[[˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţ˙ţţý˙˙ü˙˙ý˙ëůôO±Ű!™Ö$ Ů$ˇŘ$¤×'ˇÚ' Ű%ˇÜ"˘Ý#˘Ü%ˇŰ' Ů'ˇ×#˘×¤Ř¤Ů%˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř$˘Ř( Ů' Ű#˘Ü$ŁŐ%ŁŇ'˘Ő$ˇŰ ˇßZ«Ęßű˙˙˙ţ˙üöű˙úů˙ýűţţţý˙˙ü˙ţ˙˙ţ˙˙ţ˙˙˙ýţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ËĘĘ 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–З͗ΗĎΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗΗÎÍ’Ć{ŻĹý˙˙˙˙ţ˙˙˙˙ýţţ˙˙ý˙˙ý˙˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ĚĘĘ523ńďđ˙˙˙ţţţţţţýýý˙˙˙˙˙˙„„ 312-)+C@@˙˙˙ţţţ˙˙˙Ŕľż ĎÍÎ˙˙˙ýýýţţţ˙˙˙˙˙˙ĂÁ®­­˙˙˙ţ˙˙˙˙˙˙˙˙źžž ččč˙˙˙˙˙˙˙˙˙˙˙˙ýüý;99 {{{˙˙˙ţýţ˙˙˙˝Ľ˝§¦¦˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙™——$!"ĎÎÎ˙˙˙ţţţ˙˙˙cab ‡‡‡˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙vuv lkl˙˙˙˙˙˙˙˙˙BAAGDE˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙WUU644˙˙˙˙˙˙ţţţ˙˙˙|{{ \\\˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙Y´×“É•Î!”ĐÍ—Í•Í •Î–ЖΖ͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖͖ÎĚv±Ăü˙˙˙˙˙ţţ˙ü˙ýţý˙˙ţţ˙˙ý˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ĚĘĘ523ńďđ˙˙˙ţţţţţţţţţţţţţ˙ţřřřdbc" C@@˙˙˙ţ˙˙˙˙˙ÇĹĆ‹‰Šđđđ˙˙˙˙˙˙éééźžź ¸¶¶˙˙˙ţ˙˙ţţţ˙˙˙ťś› żżżâââççç˙˙˙˙˙˙ýüý;99 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 0-.GDE}z{ßßß˙˙˙˙ţ˙ţ˙ţţţţţţţ˙˙˙˙˙˙ţţţ˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙ţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ýţţţţţţţţţţţ˙˙˙˙˙˙ţţţţţţţţţ˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙ţţţţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙ýţ˙ţ˙ţţţţţţ˙˙˙˙˙˙ţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ĎĎĎLKKUSS˙˙˙˙ţ˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙ţ˙˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙öööKKKRRRŰŰŰ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙VŞŐ‡ÂŚĂŤŔŚÄŤÂŤÁ‹ÄŤÂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂŚĂ…»q¨ľ˙˙˙˙˙ýý˙˙˙ţ˙˙˙˙ţ˙˙ţ˙˙˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙žťť=:;   $ 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'%&ĎÎĎ˙˙˙ţţţ˙˙˙ţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙ţţţýýýţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţýţţţţţ˙˙˙ţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ţţţ˙˙˙ţţţţţţţţţţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙ţţţţýţ˙ýţ˙˙˙ţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ĂĂĂ)'(˙˙˙˙˙˙ţţţţţţţţţţţţýýýţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţ˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ýýýţţţ˙˙˙ţţţ˙˙˙ýýý˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙öööJJJRRRÚÚÚ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙UŞÔ …ŔŠÁ‹żŠÂ‹Ŕ‹ż‰ÂŠŔŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠÁŠŔşp¨˝˙˙˙˙˙ýý˙˙˙ţ˙˙˙˙ţ˙˙ţ˙˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ŞŞŞ [XYÖÖÖ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙äă㌊Š trs˙˙˙ţţţ˙˙˙ţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ýýýţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţ˙˙ţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ýýý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţ˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţţţţ˙ţ˙˙˙˙˙˙˙ýýý˙˙˙ýýýţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ĂÂĂ)'(˙˙˙˙ţ˙ţţţ˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙ýýý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙üüü˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙üüüĐĐĐŃŃŃőőő˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙U©Ó ľż‰˝Á‰żŠľ‡Á‰żŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔŔż‚ąo§˝ţ˙˙˙˙ţý˙˙˙ţ˙˙˙˙ţ˙˙ţ˙˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ççç"""gde˙˙˙˙˙˙˙˙˙˙ýţ˙ţţ˙ýţ˙ţţ˙˙˙˙˙˙|z{˝˝˝˙˙˙ţţţýýý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙÷÷÷îîîűűű˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙řřřďďď˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ýýýďďďýýý˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙óóóňňň˙˙˙˙˙˙˙˙˙ýýý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ńđńůřůţţţţţţţţţ˙˙˙˙˙˙˙˙˙÷÷÷đđđ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ĂÂĂ)'(˙˙˙˙˙˙˙˙˙úúúđđđýýý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙÷ö÷îíî˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙řřřďďďüúű˙˙˙˙˙˙ţţţ˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙óňňńđđ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ďďď÷÷÷˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙T¨Ň 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x°w˛v±v¬w¨x¨r§iťł˙˙˙˙˙ţý˙˙˙ţ˙˙˙˙ţ˙˙ý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙MśĂr¬ w±x«w­ xŻ x°w­ xŻwŻ v° w¶ wł x« z© yŞ x´ vµ w˛ xŻ x­ xŻ x± vŻ y® y¬ y© xŞ x® w° x« w­ x°yłvµ u˛ y° z¬x«v­u­ w®xŻv­v¬v¬u¬v­w®y° wŻ y± x® x­ x¬x­vŻw˛ v± y±y® z¬ y« xŞxŞx«w¬ w­ xŻ x±z˛ x±wŻ v± u˛ xŻ zŞ y¦ yłv¶ x· yŻv° x± y® y«v« y° w±v°u« z­ x­x¬ w« x¬ x¬ yŻy± y˛ v˛ułv±qĄhť˛˙˙˙˙˙ţý˙˙˙ţ˙˙˙˙ţ˙˙ý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙ŢŢŢĐĐŃĐĎĐĐĐĐŐŐŐőőő˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙MśĂr¬ v° wŞv­ wŻ wŻv¬ w®u®u® wł x± yŞ w¦ x© x° w˛ v°u® vŻ x˛ u˛ w˛ wŻ x¬ y« y¬yŻy˛x´x± x± w± wµ w± w­y« x­ wµ w˛ w® w®v­u­w®u­ v® vŻ x± x° wŻv¬v«v«v­u° wł w± y°{­{°z°yŻ y® x­ x­ x® w­ xŻzŻ w­v®u° w° x« y¨uĄ y°wł włv® v´ w° w«w©u«yŻy˛ x˛ w­ y¨y°x´ v˛u±v® x­x­zŻ x± v´ v˛pĄhś˛˙˙˙˙˙ţý˙˙˙ţ˙˙˙˙ţ˙˙ý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙éééÄĂĂihhMMMKIJKIJUUUś›śÔÓÓ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙M›Âq« uŻ v© u« v­ v®u« v­ v® wŻp¦r©q¬s°r­sŞq§ v® u­tŞ t­ v± v±p« n¦ p§qŞr®tł nĄ t¬ v±t° w« w¨u¨rŞw±w´vŻr§mĄm§k¨l«k«n¬q¬t®vŻ u®t«tŞtŞu¬ v°w° v­ wŞrˇr«n©k¨k«k¬k¬jŞp¬r¬ v® v¬ v¬w´p©r¨t¬q´rŞ r¤ q¤ w˛ w®v¨t©s­ v±q¦r¨t¬s±p¨t§r¨v° t˛u˛t­u©u§u©t­uŻp¤gś±˙˙˙˙˙ţý˙˙˙ţ˙˙˙˙ţ˙˙ý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙úúú‡‡‡ )'(A@@655OMNćäĺ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙M›Âp© u® v© u« v­ v®u« u­w­ nže˘ľ„­Ŕj ¸b›łcśłpźµ]žĽ i™x® x« wŞv§m›^¨É}ŻČt˘şj™±h›±k¤şŤ°Â=Ť°s¨v¸ w§tŁt« t¶s¬o›C…˘mť´¬ŇăŮěóÝëďŢęěŰëîÇáě»Ď_“¬A„¤uŻ u« u« uŞ v¬y°v®p§ iž7‡°h—­©ĚÜÓëóßíđŕëěÜëîĚăŃ[´A…¦qźt©wŞ}«ĂŞ»hś°\ťľe›±uˇ´HŤ­t® vŞ v§ u­u´u¨yŞĹŞĽmźłcš¸ešµw¤ş‚´Ę3€Ą t§wŻ v° u­s©u© 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UUU˙˙˙˙ţţđď𛚛˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙K–ľhĄnŞpŁ mĄn§o¨oĄ n¦n©nĄ oťo¦0s’í˙˙¤żĎjˇ m¤o¦c•c«Ç˙˙˙˙ý˙ţţţ˙˙˙»Ĺ _ŹŞŐđâîňeťp p§m© m¦˙˙ú˙ýýţü˙˙˙˙ŠµĂbŽo n¦p­p˘pŁoĄo¨ n¤ nĄoĄq¤oŞp«dŚĎôóýţ˙ţýű˙˙˙ˇÉŢdˇ nŁ oˇoĄpŞp¨ m¦n§oĄ nˇs  n¦ lŞ l© n§r kťP™Ä˙˙ýw«oĄpĄmˇ mť«ÍÖ˙˙˙˙ü˙˙ü˙÷˙ýf¤Ŕ/x©ţ˙˙®Ń×`Źq¦p¤p¤o¤o¤o¤oĄo¦o§o¦hśe—­˙˙˙˙ţţü˙˙˙˙˙˙˙˙ţ˙˙ţ˙˙˙ţ˙˙˙˙ţţţţţţţţţüüüLJK@==˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ýýý˙˙˙ěěě˙˙˙˙˙˙˙˙˙ HGGkjkÁżŔĐĐĐĐĐĐŇŃŇ"  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ZŽ[‘[\’\“[”^•d—jˇk jťhťkĄj˘h¤h˘q›_–j i i i i i i i i i iźb—c”Ş˙˙˙˙ţţü˙˙˙ţ˙˙ţ˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙ţţţţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙ţţţţţţţţţ˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙I’¸d›jźiťiˇiˇižk›h jžj i¨iĄhźh f¤h¤hźhźiźiťjškˇk˘h g iˇežh kžikˇkĄkźiźi˘iŁl¤iŁ fŁeĄi¨ežbś`śaścťd g¤gťlśk k©j¦i¤h hžiťiťi hˇf˘f¤c cš_žažhźjšf¤h¤h¤h¤jś bśeŁh§gˇjĄh¦gŁiśjźkžjť gžkŁiťjŁgŁfšfśiźiźiźiźiźiźiźiźiźiźižb—d”Ş˙˙˙˙˙ţü˙˙˙ţ˙˙ţ˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţ˙˙ţ˙ţ˙˙˙ţţţýýý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţţţţ˙˙˙ţţţýýý˙˙˙ţţţ˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţ˙˙˙ţţţ˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙I‘¸cšiźiťhˇh hžj›gźhťgś fˇhźhťižhžiśiˇhťhśh  f˘h hžiśhťh˘gŁfˇjśh˘hš g™ eŁgĄh›ik›l”fťhźgśkť g›e˘gĄjźk–ižj˘hźfźhˇ gť f›k k™ižiźfg¤iŁh›h–hžiźhˇf g h•g™gśh›hži i˘jŁhškśhźg jži gžgźhˇgž f–i›kˇfźj gžhźhźhźhźhźhźhźhźhźhža–b”Ş˙˙˙˙ţýü˙˙˙ţ˙˙ţ˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙ţ˙ţýţţţ˙˙ţţţ˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙ţţţ˙˙˙˙˙˙ţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙H¸`šfžjśf fźgťh›h gźgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgťgžgžgžgźgžgžgžgžgžgžgťgžgźgžgžgžgžgžgžgžgžgžgžgžgžgťgžgžgźgžgžgžgžgžgźgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgźgžgžgžgžgžgžgžgžgžgžgžgžgžgžgž_”b’¨˙˙˙˙ţţü˙˙˙ţ˙˙ţ˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţýýýţţţ˙ţţţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙ţýţţýţ˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţýýý˙˙˙ţţţ˙˙˙˙ţ˙˙ţ˙ţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţţţţýýýţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙H¸`šfžjśf fźgťh›h gźgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgž_”b’¨˙˙˙˙ţýü˙˙˙ţ˙˙ţ˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙ýýý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ýýý˙˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţýýýţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ýýý˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙H¸`šgžiśf fźgťh›h hźhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhžhť_”b’¨˙˙˙˙ţýü˙˙˙ţ˙˙ţ˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙÷÷÷ŰŰŰÚÚÚóóó˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţýýăââÜŰÜăââ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙ţţţćĺćÚŮŮŕßŕţţţ˙˙˙ýýýţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙ęęęŔŔŔľľľŇŇŇ˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙H¸`šfži›fźfźgťh›h gźgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgžgť_”b’¨˙˙˙˙ţýü˙˙˙ţ˙˙ţ˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ŰŰŰbbb_^_Ş©©˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙ţţ„‚‚cac€}~˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ýýý˙˙˙˙˙˙’‘’a_`xvw˙˙˙˙˙˙ţţţţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţţţţ˙˙˙ŕŕ੩ŠvvvzzzuuuÂÂÂ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙HŹ¸`™eťhšežežfśgšfźfžfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfťfť^“b’¨˙˙˙˙ţţü˙˙˙ţ˙˙ţ˙ţ˙˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ÉÉÉÇĹĆ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙FCD>;<˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ł˛˛===MMMëëë˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙XXX0//˙˙˙ţţţ˙˙˙ţţţţţţ˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙¬¬¬YYYşşşÉÉÉÍÍÍÁÁÁ€€€bbbööö˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙GŹ·_eťhšeždťe›f™fžeťeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeśeś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™—˙˙˙˙˙˙ţţţ˙˙˙˙˙˙˙˙˙ĹÄĹ!¦¦¦˙˙˙˙˙˙˙˙˙ŹŤŤ‹‰Š˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙^\]867˙˙˙˙˙˙˙˙˙ŐŐŐ#!"JJJ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ţýůüţţüýţ˙˙˙ńőň;‚¨R„_’b a’a”a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–a–`—a—b™b–`’_‘`“TŚ<Ąčůú˙˙ţţý˙ú˙ýú˙ýüýţ˙ý˙˙ý˙ý˙˙ţ˙ű˙˙ů˙ţ˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ĚĘĘ523ńďđ˙˙˙˙˙˙ţţţ˙˙˙ţţţ˙˙˙  C?A˙˙˙˙ţ˙˙ţţ˙˙˙€€:89ęęę˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙}~!úúúţţţţţţ˙˙˙źžž 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0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 740.28 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 756.84 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 760.56 23.76 Tm (3)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /H2 <>BDC /TT1 1 Tf 0.009 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.72 Tm [(Li)4.4 (t)-5.8 (er)-4.2 (a)10.7 (t)-5.9 (u)11.4 (r)-4.2 (e)10.7 ( )0.5 (S)2.1 (ear)6.7 (ch )0.6 (C)13.6 (r)6.7 (i)-6.5 (t)-5.8 (e)10.7 (r)-4.2 (i)-6.5 (a)10.7 ( )0.5 (an)11.3 (d )11.4 (G)-6.5 (u)11.3 (i)-6.4 (de)10.7 (l)4.4 (i)-6.5 (nes)10.7 ( )0.5 (U)2.7 (p)0.5 (d)11.3 (at)-5.8 (e)10.7 ( )0.5 (M)5.1 (et)-5.9 (h)11.3 (o)0.5 (do)11.3 (l)-6.5 (o)0.5 (gy)21.5 ( )]TJ 0 Tc 0 Tw 30.348 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc -0.004 Tw -30.348 -1.707 Td [(P)2 (r)-6 (i)2.6 (or)-6 ( t)-6.6 (o t)-6.6 (he )-10.6 (upda)10.6 (t)-6.6 (e )-10.6 (o)10.5 (f)-6.6 ( t)-6.6 (hi)13.5 (s)-2 ( )-10.6 (v)8.9 (er)-5.9 (s)-2 (i)2.6 (on )]TJ -0.005 Tc 0.01 Tw 14.902 0 Td [(o)7.5 (f)-9.6 ( t)-9.6 (h)-3.4 (e)7.5 ( NCCN G)1.3 (u)-3.4 (id)-3.3 (e)-3.4 (lin)-3.3 (e)-3.4 (s)]TJ 0 Tc 0 Tw 10.62 0 Td ( )Tj 0.283 0 Td (f)Tj -0.013 Tc 0.013 Tw 0.293 0 Td [(or)-16.9 ( )]TJ 0 Tc 0 Tw 1.152 0 Td (T)Tj -0.002 Tc 0.002 Tw 0.62 0 Td [(hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ -27.87 -1.37 Td [(C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)]TJ 0.007 Tw [(,)4.3 ( an el)2.7 (ec)8.9 (t)-6.6 (r)-6 (oni)2.6 (c)8.9 ( s)-2 (ear)-6 (c)-2 (h)10.6 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.7 (he P)2 (ubM)15.8 (ed dat)-6.6 (abas)-2 (e w)13.5 (as)-2 ( per)5 (f)-6.7 (or)4.9 (m)-5.9 (ed)10.5 ( )]TJ 0 -1.38 Td [(t)-6.6 (o ob)10.5 (t)-6.6 (ai)2.6 (n )11.3 (k)-12.9 (ey)8.8 ( l)2.7 (i)2.6 (t)-6.6 (er)-5.9 (a)10.5 (t)-6.6 (ur)-5.9 (e)]TJ 0 Tc 0 Tw 9.804 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(s)-2 (i)2.6 (nc)-2 (e t)-6.6 (he)10.5 ( pr)-5.9 (ev)8.9 (i)2.6 (ous)-2 ( )11.3 (G)-6.6 (ui)2.7 (del)2.6 (i)-8.3 (nes)-2 ( updat)-6.6 (e)10.5 (,)]TJ /TT1 1 Tf 0 Tc 0 Tw 16.63 0 Td ( )Tj /TT0 1 Tf -0.002 Tc 0.007 Tw 0.283 0 Td [(u)10.5 (s)-2 (i)2.6 (ng t)-6.6 (he)10.5 ( )]TJ -0.004 Tw -27 -1.37 Td [(f)-6.6 (ol)2.7 (l)2.6 (ow)2.6 (i)2.6 (ng)-11.2 ( )-10.6 (s)-2 (ear)4.9 (c)-2 (h t)-6.6 (er)4.9 (m)-6 (:)4.3 ( )]TJ 0.007 Tw 9.978 0 Td [(t)-6.6 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.7 (nom)-6 (a)]TJ 0 Tc 0 Tw (.)Tj /TT1 1 Tf 8.141 0 Td ( )Tj /TT0 1 Tf -0.002 Tc 0.007 Tw 0.272 0 Td [(T)-10.6 (he)10.5 ( P)2 (ubM)15.8 (ed dat)-6.6 (abas)-2 (e w)13.5 (as)-2 ( )]TJ -18.391 -1.38 Td [(c)-2 (hos)-2 (en bec)-2 (aus)-2 (e)10.6 ( i)2.7 (t)4.2 ( r)-5.9 (e)10.5 (m)-6 (ai)2.6 (ns)-2 ( t)-6.6 (he)10.5 ( m)-6 (o)10.6 (s)-2 (t)4.2 ( w)13.5 (i)2.6 (del)-8.2 (y)]TJ 0 Tc 0 Tw 18.989 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(us)-2 (ed )-10.6 (r)-6 (es)-1.9 (our)-6 (c)-2 (e)10.5 ( f)-17.5 (o)10.5 (r)-5.9 ( m)-5.9 (edi)2.6 (c)-2 (al)2.6 ( )]TJ 0.007 Tw -19.272 -1.37 Td [(l)2.6 (i)2.6 (t)-6.6 (er)-6 (at)-6.6 (ur)-5.9 (e)10.5 ( and i)2.6 (ndex)8.9 (es)-2 ( pe)10.5 (er)]TJ 0 Tc 0 Tw 11.804 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(r)-6 (ev)8.9 (i)2.6 (ew)13.5 (ed bi)2.6 (om)-5.9 (edi)2.6 (c)-2 (al)2.5 ( l)2.7 (i)-8.3 (t)-6.6 (er)-6 (a)10.5 (t)-6.6 (ur)-6 (e)10.5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 306.12 423 Tm (31)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 313.8 419.04 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -26.576 -2.37 Td [(T)-10.6 (he)10.5 ( s)-2 (ear)-5.9 (c)-2 (h)10.5 ( r)-6 (e)10.5 (s)-2 (ul)2.6 (t)-6.6 (s)-2 ( w)13.5 (er)-5.9 (e )11.3 (nar)-6 (r)-5.9 (ow)13.4 (ed by)8.8 ( s)-2 (el)2.6 (ec)-2 (t)-6.6 (i)2.6 (ng s)-2 (t)4.2 (udi)2.6 (es)-2 ( i)2.6 (n hum)-6 (ans)8.9 ( )]TJ 0 -1.38 Td [(publ)2.6 (i)2.6 (s)-2 (hed i)2.7 (n E)1.9 (ng)-11.2 (l)2.6 (i)2.6 (s)-2 (h.)4.2 ( R)2.6 (es)-2 (ul)2.6 (t)-6.6 (s)-2 ( w)13.5 (er)-6 (e c)-2 (on)10.5 (f)-17.4 (i)2.6 (ned)10.5 ( t)-6.6 (o)10.5 ( t)-6.6 (h)10.5 (e )11.3 (f)-17.5 (ol)2.6 (l)2.6 (ow)13.5 (i)2.6 (ng)-11.2 ( ar)-6 (t)-6.6 (i)2.6 (c)-2 (l)2.6 (e )11.2 (t)]TJ 0.002 Tw 29.652 0 Td [(y)8.9 (pes)-2 (:)-6.6 ( )]TJ -0.005 Tc 0.01 Tw -29.652 -1.37 Td [(Clin)-3.3 (ic)-5 (a)-3.4 (l T)-13.6 (r)-8.9 (ia)-3.4 (l,)-9.6 ( P)-1.1 (h)-3.3 (a)-3.4 (s)-5 (e)-3.3 ( )11.2 (I)1.3 (I)]TJ 0 Tc 0 Tw 9.641 0 Td (;)Tj 0.272 0 Td ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(Clin)-3.3 (ic)-5 (a)-3.4 (l T)-13.6 (r)-8.9 (ia)-3.4 (l,)-9.6 ( P)-1.1 (h)-3.3 (a)-3.4 (s)-5 (e)7.6 ( I)1.3 (I)-9.6 (I)]TJ 0.005 Tc -0.005 Tw 9.913 0 Td (; )Tj -0.005 Tc 0.01 Tw 0.565 0 Td [(Clin)-3.3 (ic)-5 (a)-3.4 (l T)-13.6 (r)-8.9 (ia)-3.4 (l,)1.3 ( P)-1.1 (h)-3.3 (a)-3.4 (s)-5 (e)-3.3 ( )11.2 (I)-9.6 (V)-1.1 (;)1.3 ( )]TJ -0.002 Tc 0.007 Tw -20.674 -1.38 Td [(G)-6.6 (ui)2.7 (del)2.6 (i)2.6 (ne;)-6.6 ( R)2.6 (ando)]TJ -0.004 Tw [(m)-6 (i)2.6 (z)8.9 (ed C)2.6 (ont)-6.6 (r)-6 (ol)2.6 (l)2.6 (ed T)-10.6 (r)-5.9 (i)2.6 (al)2.6 (;)-6.6 ( )-10.6 (M)15.8 (et)-6.6 (a)]TJ 0 Tc 0 Tw (-)Tj 0.005 Tw 20.5 0 Td [(A)4 (n)12.5 (a)1.6 (l)4.6 (y)10.9 (si)4.6 (s;)-4.6 ( S)3.9 (y)10.9 (st)-4.6 (e)1.7 (m)-4 (a)1.7 (t)-4.6 (i)4.6 (c )]TJ -0.002 Tc 0.007 Tw -20.5 -1.37 Td [(R)2.6 (ev)8.8 (i)2.6 (e)-11.2 (w)13.5 (s)-2 (;)-6.6 ( and V)1.9 (al)2.6 (i)2.6 (dat)-6.6 (i)2.6 (on S)1.9 (t)-6.6 (udi)2.6 (es)-2 (.)-6.6 ( )]TJ 0 Tc 0 Tw 14.793 0 Td ( )Tj EMC /P <>BDC -0.002 Tc -0.004 Tw -14.793 -2.38 Td [(T)-10.6 (he)10.5 ( )-10.6 (dat)-6.6 (a)10.5 ( f)-6.6 (r)-6 (om)4.9 ( k)-12.9 (ey)8.9 ( )]TJ 0.007 Tw 8.315 0 Td [(P)2 (ubM)4.9 (ed ar)4.9 (t)-6.6 (i)2.7 (c)-2.1 (l)2.7 (e)]TJ 0 Tc 0 Tw (s )Tj -0.002 Tc 0.007 Tw 7.424 0 Td [(as)-2 ( w)13.4 (el)2.6 (l)2.6 ( as)-2 ( ar)4.9 (t)-6.6 (i)2.6 (c)-2 (l)2.6 (es)-2 ( )11.2 (f)-6.6 (r)-5.9 (om)4.9 ( addi)2.6 (t)-6.6 (i)2.6 (onal)2.6 ( )]TJ -15.739 -1.37 Td [(s)-2 (our)-6 (c)-2 (es)8.9 ( deem)-5.9 (ed)10.5 ( as)-2 ( )11.3 (r)-6 (el)2.6 (e)10.5 (v)8.9 (ant)-6.6 ( t)-6.6 (o )11.3 (t)-6.6 (hes)-2 (e)10.5 ( )]TJ 0 Tc 0 Tw 16.609 0 Td (g)Tj -0.002 Tc 0.002 Tw 0.565 0 Td [(ui)2.6 (del)2.6 (i)2.6 (nes)]TJ 0 Tc 0 Tw 3.924 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(and di)2.6 (s)-2 (c)-2 (us)-2 (s)-2 (ed by)8.9 ( )11.3 (t)-6.6 (he )]TJ 0.002 Tw -21.38 -1.38 Td [(panel)2.6 ( )]TJ 0.007 Tw 2.717 0 Td [(hav)8.9 (e been i)2.7 (nc)-2 (l)2.6 (uded i)2.6 (n t)-6.6 (hi)2.6 (s)8.9 ( )]TJ 0 Tc 0 Tw (v)Tj -0.002 Tc 0.007 Tw 12.293 0 Td [(er)-6 (s)-2 (i)2.6 (on o)10.5 (f)-6.6 ( t)-6.6 (he)10.5 ( )]TJ [(D)2.6 (i)2.6 (s)-2 (c)-2 (us)-2 (s)-2 (i)2.6 (on s)-2 (ec)8.9 (t)-6.6 (i)2.6 (on)]TJ 0 Tc 0 Tw ( )Tj -0.013 Tc 0.007 Tw 14.304 0 Td [(\()-17 (eg)-11.4 (,)-17.6 ( e)]TJ 0 Tc 0 Tw 2.543 0 Td (-)Tj -0.002 Tc 0.007 Tw -31.859 -1.37 Td [(publ)2.6 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (ons)-2 ( ahead o)10.5 (f)-6.6 ( p)10.5 (r)-5.9 (i)2.6 (nt)-6.6 (,)4.3 ( m)-6 (ee)10.5 (t)-6.6 (i)2.6 (ng abs)8.9 (t)-6.6 (r)-6 (ac)8.9 (t)-6.7 (s)8.9 (\))]TJ -0.004 Tw 20.391 0 Td [(.)4.3 ( )-10.7 (R)2.7 (ec)-2 (om)-6 (m)-5.9 (en)10.5 (dat)-6.6 (i)2.7 (ons)-2 ( f)-6.6 (or)4.9 ( )]TJ -0.005 Tc 0.01 Tw -20.391 -1.38 Td [(w)10.5 (h)-14.3 (ic)-5.1 (h)-3.3 ( h)-3.4 (ig)-14.2 (h)]TJ 0 Tc 0 Tw 4.717 0 Td (-)Tj -0.005 Tc 0.005 Tw 0.337 0 Td [(le)-3.3 (v)5.8 (e)-3.3 (l )]TJ -0.002 Tc 0.007 Tw 2.315 0 Td [(ev)8.8 (i)2.6 (denc)-12.9 (e i)2.6 (s)]TJ 0 Tc 0 Tw 4.989 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(l)2.6 (ac)8.8 (k)-12.8 (i)2.6 (n)10.5 (g)-11.2 ( a)10.5 (r)-6 (e bas)-2 (ed)10.5 ( on)10.6 ( t)-6.6 (he)10.5 ( panel)2.6 <92>2.6 (s)-2 ( r)-5.9 (ev)8.9 (i)2.6 (ew)13.5 ( of)-17.5 ( )]TJ -0.016 Tc 0.016 Tw -12.641 -1.37 Td [(l)-11.4 (o)-25.2 (w)-0.6 (e)-14.3 (r)]TJ 0 Tc 0 Tw 2.38 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(l)2.6 (ev)8.8 (el)2.6 ( ev)-1.9 (i)2.6 (denc)-2 (e and ex)8.9 (per)-6 (t)-6.6 ( opi)2.6 (ni)2.6 (on.)4.2 ( )]TJ 0 Tc 0 Tw 15.337 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -18.054 -2.37 Td [(T)-10.6 (he)10.5 ( c)-2 (om)-6 (pl)2.6 (e)10.5 (t)-6.6 (e de)10.5 (t)-6.6 (ai)2.6 (l)2.6 (s)-2 ( o)10.5 (f)-6.6 ( t)4.3 (he )]TJ 0 Tc 0 Tw (D)Tj -0.002 Tc 0.007 Tw 12.967 0 Td [(ev)8.8 (el)2.6 (opm)-6 (ent)-6.6 ( and)10.6 ( U)2.6 (pdat)-6.6 (e o)10.5 (f)-6.6 ( )11.3 (t)-6.7 (he N)2.6 (C)2.6 (C)2.6 (N)2.6 ( )]TJ 0.002 Tw -12.967 -1.38 Td [(G)-6.6 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( )]TJ 4.989 0 Td [(ar)-6 (e)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 1.728 0 Td [(av)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e on t)-6.6 (he)10.5 ( N)2.6 (C)2.7 (C)2.6 (N)2.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(w)13.5 (ebpag)-11.2 (e)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.16 188.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 212.52 186.6 44.64 0.841 re f EMC BT /H2 <>BDC /CS1 cs 0 scn /TT1 1 Tf -0.002 Tc 0.018 Tw 11.04 -0 0 11.04 23.52 162.24 Tm [(M)-16.8 (a)-11.2 (n)-10.6 (a)-11.2 (gi)-17.5 (ng)-10.5 ( )0.5 (D)2.6 (i)-6.6 (f)-16.9 (f)-16.8 (er)-15.2 (e)-11.2 (nt)-6 (i)-17.4 (a)-11.3 (t)-5.9 (ed)-10.6 ( )0.5 (Th)-21.4 (y)10.5 (r)-15.2 (o)-10.5 (i)-17.5 (d )0.5 (C)-8.2 (a)-11.3 (r)-15.1 (ci)-17.4 (n)-10.6 (om)-15.2 (a )]TJ 0 Tc 0 Tw 21.359 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc -0.004 Tw -21.359 -1.696 Td [(M)15.8 (anag)-11.2 (i)2.6 (ng)-11.2 ( )-10.6 (di)13.5 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.6 (t)-6.7 (i)2.7 (at)-6.6 (ed \()4.9 (i)2.6 (e,)-6.6 ( )-10.6 (papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 (,)-6.6 ( f)-17.5 (o)]TJ -0.005 Tc 0.01 Tw [(llic)-5 (u)-3.3 (la)-3.4 (r)-8.9 (,)-9.6 ( H)]TJ 0 Tc 0 Tw Tj -0.002 Tc 0.007 Tw 22.098 0 Td [(r)-6 (t)-6.6 (hl)2.6 (e c)-2.1 (el)2.6 (l)2.6 (\))5 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ -22.098 -1.38 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( c)-2 (an be)10.6 ( a )11.3 (c)-2 (hal)2.6 (l)2.6 (eng)-11.2 (e)10.5 (,)-6.6 ( bec)-2 (au)10.5 (s)-2 (e un)10.5 (t)-6.6 (i)2.6 (l)2.6 ( r)-5.9 (ec)-2 (e)10.5 (nt)-6.6 (l)2.6 (y)8.9 (,)-6.6 ( )11.2 (f)-17.5 (ew)13.5 ( pr)-5.9 (os)-2 (pec)8.9 (t)-6.6 (i)2.6 (v)8.9 (e )]TJ 0 -1.37 Td [(r)-6 (andom)-6 (i)2.6 (z)8.9 (ed t)4.2 (r)-5.9 (i)2.6 (al)2.7 (s)-2 ( o)10.5 (f)-6.6 ( t)4.2 (r)-5.9 (eat)4.3 (m)-6 (ent)4.3 ( hav)8.8 (e been done)10.6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 254.16 117.12 Tm [(32,)-1.8 (33)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 271.44 113.16 Tm ( )Tj -0.002 Tc 0.007 Tw 0.293 0 Td [(M)15.8 (os)-2 (t)-6.6 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.5 ( i)2.6 (n)10.5 (f)-17.4 (or)4.9 (m)-5.9 (a)10.5 (t)-6.6 (i)2.6 (on )]TJ -22.75 -1.38 Td [(about)-6.6 ( )11.3 (t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-6 (en)10.5 (t)-6.6 ( )11.3 (c)-2 (om)-5.9 (es)8.9 ( )11.3 (f)-6.7 (r)4.9 (om)-6 ( s)8.9 (t)-6.6 (udi)2.6 (es)-2 ( o)10.5 (f)-6.6 ( l)2.6 (ar)4.9 (g)-11.3 (e)10.6 ( c)-2 (oho)10.5 (r)-6 (t)-6.6 (s)8.9 ( o)10.5 (f)]TJ 0 Tc 0 Tw 24.152 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 (s)-2 ( f)-6.6 (or)4.9 ( )-10.6 (w)13.5 (hom)-6 ( )]TJ 0.007 Tw -24.435 -1.37 Td [(t)-6.6 (her)-6 (apy)8.8 ( has)-2 ( n)10.5 (ot)4.3 ( been )11.2 (r)-5.9 (an)10.5 (dom)-6 (l)2.6 (y)8.9 ( as)-2 (s)-2 (i)2.6 (g)-11.2 (ned)10.6 (.)-6.6 ( )11.2 (T)-10.5 (hi)2.6 (s)-2 ( a)10.5 (c)8.9 (c)-2 (ount)-6.6 (s)-2 ( )11.2 (f)-6.6 (or)4.9 ( )11.3 (m)-6 (uc)-2.1 (h o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (he)10.6 ( )]TJ 0 -1.38 Td [(di)2.6 (s)-2 (ag)-11.2 (r)-6 (ee)10.5 (m)-5.9 (en)10.5 (t)-6.6 ( abou)10.5 (t)-6.6 ( )11.3 (m)-6 (an)10.5 (ag)-11.3 (i)2.7 (n)10.5 (g)-11.3 ( di)13.5 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed)10.6 ( c)-2 (ar)4.9 (c)-2 (i)2.6 (nom)-5.9 (a.)4.3 ( N)2.6 (onet)-6.6 (hel)2.6 (es)-2 (s)8.9 (,)-6.6 ( )]TJ 0 -1.37 Td [(m)-6 (os)-2 (t)4.3 ( pat)-6.6 (i)2.6 (en)10.6 (t)-6.7 (s)-2 ( c)-2 (a)10.6 (n be)10.5 ( c)-2 (ur)5 (ed o)10.6 (f)-6.6 ( t)-6.6 (hi)2.6 (s)8.9 ( di)2.7 (s)-2.1 (eas)-2 (e w)13.5 (hen pr)-6 (oper)-6 (l)2.7 (y)8.8 ( t)-6.6 (r)-5.9 (ea)10.5 (t)-6.6 (ed by)8.9 ( )]TJ 34.554 41.804 Td [(ex)8.8 (per)-5.9 (i)2.6 (enc)-2 (ed phy)8.9 (s)-2 (i)2.6 (c)-2 (i)2.6 (ans)-2 ( and s)-2 (ur)4.9 (g)-11.2 (e)]TJ 0.002 Tw [(ons)8.8 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 592.2 517.92 Tm (34)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 599.88 513.96 Tm ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(T)-10.6 (he )11.3 (t)-6.6 (r)-5.9 (ea)10.5 (t)-6.6 (m)-6 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( c)8.9 (hoi)2.6 (c)-2 (e i)2.6 (s)-2 ( )]TJ -17.924 -1.38 Td [(s)-2 (ur)4.9 (g)-11.3 (er)-5.9 (y)8.8 (,)-6.6 ( )11.3 (f)-6.6 (ol)2.6 (l)2.7 (ow)13.5 (ed by)8.9 ( r)-6 (adi)-8.3 (oac)-2 (t)-6.6 (i)2.6 (v)8.9 (e i)]TJ 0.002 Tw 14.457 0 Td [(odi)2.6 (ne)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 2.717 0 Td [(\()-6 (R)2.7 (A)1.9 (I)-6.6 (\))4.9 ( abl)2.6 (at)-6.6 (i)2.6 (on)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 6.38 0 Td [([)-6.6 (i)2.6 (odi)2.6 (ne 131)10.5 ( \()]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 725.64 502.68 Tm (131)Tj 0.005 Tc -0.005 Tw 11.04 -0 0 11.04 737.16 498.72 Tm (I\))Tj 0 Tc 0 Tw 0.62 0 Td (])Tj 0.272 0 Td ( )Tj -0.005 Tc 0.005 Tw 0.283 0 Td [(in)-3.3 ( )]TJ -0.002 Tc 0.007 Tw -31.261 -1.37 Td [(s)-2 (el)2.6 (ec)-2 (t)-6.6 (ed pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( )]TJ 0.002 Tw (and)Tj 0 Tc 0 Tw ( )Tj -0.002 Tc 0.002 Tw 9.696 0 Td [(t)-6.6 (hy)8.8 (r)-5.9 (ox)8.9 (i)2.6 (ne )]TJ 0.007 Tw 4.315 0 Td [(t)-6.6 (her)-6 (apy)8.9 ( i)2.6 (n m)-6 (o)]TJ 6.043 0 Td [(s)-2 (t)4.3 ( p)10.5 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 (.)]TJ 0 Tc 0 Tw 4.815 0 Td ( )Tj EMC /H2 <>BDC /TT1 1 Tf 0.009 Tc -0.009 Tw -24.87 -2.402 Td [(R)2.7 (ad)0.5 (i)-6.5 (a)10.6 (t)5.1 (i)-6.5 (o)0.5 (n)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.018 Tw 4.967 0 Td [(I)-17.5 (nd)-10.5 (u)-10.6 (c)-11.2 (e)-11.2 (d )0.5 (Th)-21.4 (yr)-15.1 (o)-10.6 (i)-6.6 (d)-10.6 ( )0.6 (C)-8.3 (ar)-15.1 (ci)-17.5 (n)-10.5 (om)-15.2 (a)]TJ 0 Tc 0 Tw ( )Tj 13.685 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw -18.652 -1.696 Td [(E)2 (x)8.8 (pos)-2 (ur)-6 (e t)-6.6 (o i)2.6 (oni)2.7 (z)8.8 (i)2.6 (ng)-11.2 ( r)-6 (adi)13.5 (at)-6.7 (i)2.6 (on i)2.6 (s)-2 ( )11.2 (t)-6.6 (he onl)2.7 (y)8.8 ( )11.3 (k)-12.9 (now)13.5 (n env)8.8 (i)2.6 (r)-5.9 (onm)-6 (ent)-6.6 (al)2.6 ( c)-2 (aus)-2 (e)10.5 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.37 Td [(t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a and)10.5 ( u)10.5 (s)-2 (ual)2.6 (l)2.6 (y)8.9 ( c)-2 (aus)-2 (es)-2 ( papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 689.4 427.2 Tm (35)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 697.08 423.24 Tm ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(T)-10.6 (he)10.5 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ -26.728 -1.38 Td [(g)-11.2 (l)2.6 (ands)-2 ( o)10.5 (f)-6.6 ( )11.2 (c)-2 (hi)2.6 (l)2.6 (dr)-5.9 (en ar)-6 (e)10.5 ( es)8.8 (pec)-2 (i)2.6 (al)2.6 (l)-8.2 (y)8.8 ( v)8.9 (ul)2.6 (ner)-6 (abl)2.6 (e t)-6.6 (o i)2.6 (oni)2.6 (z)-2 (i)2.7 (ng)-11.2 ( r)-6 (adi)2.7 (a)10.5 (t)-6.6 (i)2.6 (on.)-6.6 ( A)12.8 ( c)-2 (hi)2.6 (l)2.6 <6492>2.6 (s)-2 ( )]TJ 0 -1.37 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d g)-11.2 (l)2.6 (and)10.5 ( has)-2 ( one)10.5 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (he hi)13.5 (g)-11.2 (hes)-2 (t)4.3 ( r)-6 (i)2.6 (s)8.9 (k)-2 (s)-2 ( o)10.5 (f)-6.6 ( dev)8.9 (el)2.5 (opi)2.6 (ng)-11.2 ( c)-2 (an)10.5 (c)-2 (er)4.9 ( o)10.6 (f)-6.6 ( any)8.8 ( )]TJ 0 -1.38 Td [(or)4.9 (g)-11.3 (an.)4.2 ( )11.3 (T)-10.6 (he )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )11.2 (g)-11.2 (l)2.6 (and )11.2 (i)2.7 (s)-2 ( t)-6.7 (he onl)2.6 (y)8.8 ( or)4.9 (g)-11.2 (an)10.6 ( l)2.6 (i)2.6 (nk)-12.8 (ed)10.5 ( t)4.3 (o )0.5 (r)-6 (i)2.6 (s)8.9 (k)-2 ( at)4.3 ( about)4.3 ( 0.)-6.6 (10)10.5 ( )11.2 (G)-6.6 (y)8.9 (.)]TJ 0 Tc 0 Tw 6.96 -0 0 6.96 759.72 381.6 Tm (5)Tj 11.04 -0 0 11.04 763.56 377.64 Tm ( )Tj -0.002 Tc -0.004 Tw -32.478 -1.37 Td [(T)-10.6 (he)10.5 ( )-10.6 (r)-5.9 (i)2.6 (s)8.8 (k)-2 ( f)-17.5 (o)10.6 (r)-6 ( r)-6 (adi)2.6 (at)-6.6 (i)2.6 (on)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.424 0 Td [(i)2.6 (nd)10.5 (uc)-1.9 (ed t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( i)2.6 (s)-2 ( )11.2 (g)-11.2 (r)-5.9 (ea)10.5 (t)-6.6 (er)4.9 ( i)2.6 (n )11.2 (f)-17.4 (e)10.5 (m)-6 (al)2.6 (es)-2 (,)4.3 ( )]TJ -9.424 -1.38 Td [(c)-2 (er)-6 (t)-6.6 (ai)2.7 (n )11.3 (J)-2 (ew)13.5 (i)2.6 (s)-2 (h popul)2.6 (at)-6.6 (i)2.6 (ons)-2 (,)-6.7 ( and)]TJ 0 Tc 0 Tw 13.902 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h a )11.3 (f)-6.6 (a)10.5 (m)-5.9 (i)2.6 (l)2.6 (y)8.9 ( hi)2.6 (s)-2 (t)-6.6 (or)-6 (y)8.9 ( o)10.5 (f)-17.5 ( )11.3 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0.002 Tw -14.185 -1.37 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 458.88 336.12 Tm (36)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 466.56 332.16 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (hes)8.9 (e da)10.5 (t)-6.6 (a )11.3 (s)-2 (ugg)-11.2 (es)8.9 (t)-6.6 ( )11.2 (t)-6.6 (ha)10.5 (t)-6.6 ( )11.3 (g)-11.3 (ene)10.6 (t)-6.6 (i)2.6 (c)-2 ( )11.2 (f)-6.6 (ac)-2 (t)4.2 (or)-6 (s)-2 ( a)10.6 (r)-6 (e al)2.6 (s)-2 (o)10.5 ( i)2.6 (m)-5.9 (por)4.9 (t)-6.6 (ant)4.3 ( i)2.6 (n )]TJ -5.859 -1.38 Td [(t)-6.6 (he dev)8.9 (el)2.6 (opm)-5.9 (ent)4.2 ( o)10.6 (f)-6.6 ( t)-6.7 (hy)8.9 (r)-6 (o)10.5 (i)2.7 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( B)1.9 (e)10.5 (g)-11.2 (i)2.7 (nni)2.6 (n)10.5 (g)-11.2 ( )11.2 (w)2.7 (i)2.6 (t)-6.6 (hi)2.6 (n 5 y)8.9 (ear)-6 (s)-2 ( o)10.6 (f)-6.7 ( )]TJ 0 -1.37 Td [(i)2.6 (r)-6 (r)-5.9 (adi)2.6 (at)-6.6 (i)2.6 (on dur)-6 (i)2.6 (n)10.5 (g c)-2 (hi)2.6 (l)2.6 (dhood,)-6.7 ( new)13.5 ( nodul)2.6 (es)-2 ( dev)8.9 (el)2.6 (op at)4.2 ( a )11.3 (r)-6 (at)-6.7 (e)10.6 ( o)10.5 (f)-6.6 ( about)4.3 ( 2%)6.6 ( )]TJ 0 -1.38 Td [(annual)2.6 (l)2.6 (y)8.8 (,)-6.6 ( r)-5.9 (eac)-2 (hi)2.7 (ng)-11.2 ( a)10.5 ( pea)]TJ 10.859 0 Td [(k)-2 ( i)2.6 (nc)-2 (i)2.6 (denc)-2 (e w)13.5 (i)2.6 (t)-6.6 (hi)2.6 (n 30 y)8.9 (ear)-6 (s)-2 ( o)10.5 (f)-6.6 ( i)2.6 (r)4.9 (r)-5.9 (adi)2.6 (at)-6.5 (i)2.5 (on bu)10.5 (t)-6.6 ( )]TJ -10.859 -1.37 Td [(r)-6 (em)-6 (ai)2.6 (ni)2.6 (ng hi)13.5 (g)-11.2 (h a)10.6 (t)-6.7 ( 40)10.5 ( y)8.9 (ear)-6 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 537.84 275.4 Tm [(5,)-1.9 (6)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 547.44 271.44 Tm ( )Tj 0.272 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -13.174 -2.38 Td [(A)2 (dul)2.6 (t)-6.6 (s)-2 ( hav)8.8 (e a v)8.9 (er)-6 (y)8.9 ( s)-2 (m)-6 (al)2.6 (l)2.6 ( )11.3 (r)-6 (i)2.6 (s)-2 (k)-2 ( o)10.5 (f)-6.6 ( dev)8.9 (el)2.6 (opi)2.6 (ng)-11.2 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-1.9 (i)2.6 (no)10.5 (m)-5.9 (a a)10.6 (f)-6.6 (t)-6.7 (e)10.6 (r)-6 ( )]TJ 0 -1.37 Td [(ex)8.8 (pos)-2 (ur)-6 (e t)-6.6 (o )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 465.72 234 Tm (131)Tj 0.005 Tc -0.005 Tw 11.04 -0 0 11.04 477.24 230.04 Tm (I.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 483.48 234 Tm (37)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 491.16 230.04 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)12.8 (f)-6.6 (t)-6.6 (er)4.9 ( t)4.2 (he C)2.7 (her)-5.9 (noby)8.8 (l)2.6 ( nuc)-2.1 (l)2.7 (ear)-6 ( )11.3 (r)-6 (e)10.5 (ac)-2 (t)-6.6 (or)4.9 ( )0.5 (ac)-2 (c)-2 (i)2.6 (dent)4.2 ( i)2.6 (n 1986)10.6 (,)-6.6 ( )]TJ -8.087 -1.37 Td [(m)-6 (any)8.9 ( c)-2 (hi)2.6 (l)2.6 (dr)-5.9 (en and adol)2.6 (e)10.5 (s)-2 (c)-2 (ent)-6.7 (s)8.9 ( dev)8.9 (el)2.6 (oped papi)2.6 (l)2.6 (l)2.6 (a)-11.2 (r)-5.9 (y)8.8 ( )]TJ 0.002 Tw 22.88 0 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (as)]TJ 0 Tc 0 Tw 5.098 0 Td ( )Tj -0.013 Tc 0.013 Tw 0.283 0 Td [(af)-17.6 (t)-17.6 (er)-16.9 ( )]TJ -0.002 Tc -0.004 Tw -28.261 -1.38 Td [(bei)2.6 (ng)-11.2 ( )-10.7 (ex)8.9 (pos)-2 (ed t)-6.7 (o )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 492 203.64 Tm (131)Tj -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 503.52 199.68 Tm [(I)-6.6 ( f)-6.6 (al)2.6 (l)2.6 (out)-6.6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 542.16 203.64 Tm (38)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 549.84 199.68 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)4.3 (t)-6.7 ( )0.5 (be)10.5 (c)-2 (am)-6 (e)10.6 ( ev)8.9 (i)2.6 (dent)-6.6 ( t)4.3 (hat)-6.6 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 664.32 203.64 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 675.84 199.68 Tm [(I)-6.6 ( and o)10.6 (t)-6.6 (her)4.9 ( )]TJ 0.002 Tw -24.533 -1.37 Td [(s)-2 (hor)-6 (t)]TJ 0 Tc 0 Tw 2.217 0 Td (-)Tj -0.005 Tc 0.005 Tw 0.337 0 Td [(liv)5.9 (e)-3.4 (d)-3.3 ( )]TJ -0.004 Tc 0.004 Tw 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0 Tw 10.141 0 Td ( )Tj 0.272 0 Td ( )Tj EMC ET endstream endobj 676 0 obj 26282 endobj %% Contents for page 66 %% Original object ID: 133 0 677 0 obj << /Length 678 0 R >> stream Q q BT /Xi64 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 678 0 obj 245 endobj %% Contents for page 67 %% Original object ID: 134 0 679 0 obj << /Length 680 0 R >> stream q endstream endobj 680 0 obj 2 endobj %% Contents for page 67 %% Original object ID: 11394 0 681 0 obj << /Length 682 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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[(eni)13.5 (g)-11.2 (n)10.5 ( di)2.6 (s)-2 (eas)-2 (e.)-6.6 ( )11.3 (T)-10.6 (he)10.5 ( ot)-6.5 (he)10.5 (r)-5.9 ( 50)10.5 (%)-4.3 ( a)10.6 (r)-6 (e )]TJ -0.013 Tc 0.013 Tw 20.848 0 Td [(of)-6.7 (t)-17.6 (e)-11.4 (n)]TJ 0 Tc 0 Tw 2.207 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(f)-17.5 (i)13.5 (r)-6 (s)-2 (t)4.3 ( no)10.5 (t)-6.6 (i)2.6 (c)-2 (ed by)8.9 ( t)-6.6 (he)10.6 ( )]TJ -23.326 -1.38 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (,)4.3 ( us)-2 (ual)2.6 (l)2.7 (y)8.8 ( as)-2 ( an as)8.9 (y)8.9 (m)-6 (pt)-6.7 (om)-6 (a)10.6 (t)-6.6 (i)2.6 (c)-2 ( nodul)2.6 (e)]TJ 0 Tc 0 Tw (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 237.12 342.24 Tm [(1,)-1.9 (44)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 250.56 338.28 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(R)2.6 (egr)-5.9 (et)4.3 (t)-6.6 (abl)2.6 (y)]TJ -0.005 Tc 0.01 Tw 5.087 0 Td [(,)-9.6 ( t)-9.6 (h)-3.4 (e)7.5 ( t)-9.6 (y)5.9 (p)-3.4 (ic)-5 (a)-3.4 (lly)5.8 ( )]TJ -0.002 Tc 0.007 Tw -25.935 -1.37 Td [(i)2.6 (ndol)2.6 (ent)-6.6 ( nat)-6.6 (ur)-5.9 (e)10.5 ( o)10.5 (f)-6.6 ( di)13.5 (f)-6.6 (f)-6.6 (er)-6 (e)10.5 (nt)-6.6 (i)2.6 (at)-6.6 (ed )11.2 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (no)10.6 (m)4.9 (a o)10.6 (f)-6.7 (t)-6.6 (en l)2.6 (eads)8.9 ( t)-6.6 (o)10.5 ( l)2.6 (ong )]TJ 0 -1.38 Td [(del)2.6 (ay)8.8 (s)-2 ( i)2.6 (n di)2.7 (ag)-11.2 (nos)-2 (i)2.6 (s)-2 ( t)-6.6 (ha)10.5 (t)4.2 ( )11.3 (m)-6 (ay)8.9 ( s)-2 (ubs)-2 (t)-6.6 (an)10.6 (t)-6.7 (i)2.7 (al)2.6 (l)2.6 (y)8.9 ( )-10.5 (w)13.5 (or)-5.9 (s)-2 (en t)-6.6 (he)10.6 ( c)-2 (our)-6 (s)-2 (e)10.5 ( o)10.6 (f)-6.7 ( )11.3 (t)-6.6 (he )]TJ 0.002 Tw 0 -1.37 Td [(di)2.6 (s)-2 (eas)-2 (e.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 64.56 296.76 Tm (11)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 72.24 292.8 Tm ( )Tj 0.283 0 Td ( )Tj EMC /H2 <>BDC /TT1 1 Tf -0.002 Tc 0.007 Tw -4.696 -2.402 Td [(I)-17.5 (ni)-17.5 (t)-5.9 (i)-17.5 (al)-17.5 ( W)-14.5 (or)-15.2 (k)-11.2 (u)-10.6 (p )]TJ 0 Tc 0 Tw ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw 0 -1.696 Td [(For)-6 ( a)10.5 ( pat)-6.6 (i)2.6 (ent)4.3 ( w)13.5 (i)2.6 (t)-6.6 (h a t)-6.6 (hy)8.9 (r)-6 (o)10.6 (i)2.6 (d nodul)2.6 (e,)-6.6 ( t)-6.6 (h)10.5 (e )11.3 (f)-17.5 (i)13.5 (r)-5.9 (s)-2 (t)4.2 ( s)8.9 (t)-6.6 (ep i)2.6 (s)8.9 ( t)-6.6 (o)10.5 ( m)-6 (eas)-2 (u)10.5 (r)-5.9 (e )11.3 (t)-6.6 (he)10.5 ( s)-2 (er)-5.9 (u)10.5 (m)-6 ( )]TJ -0.004 Tw 0 -1.37 Td [(t)-6.6 (hy)8.8 (r)-5.9 (ot)-6.6 (r)-5.9 (opi)2.6 (n \()-6 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 8.652 0 Td [(s)8.9 (t)-6.6 (i)2.6 (m)-6 (u)10.5 (l)2.7 (at)-6.6 (i)2.6 (ng)-11.3 ( )-10.6 (ho)10.5 (r)4.9 (m)-5.9 (one [)4.3 (T)-10.6 (S)1.9 (H)2.7 (])-6.7 (\))5 ( )]TJ 0.007 Tw 12.402 0 Td [(l)2.6 (ev)8.8 (el)2.6 ( and )0.5 (t)-6.7 (o do)10.6 ( an )]TJ -21.054 -1.38 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2 (ound o)10.5 (f)-6.6 ( )11.2 (t)-6.6 (he)10.5 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ 10.967 0 Td [(and nec)8.8 (k)]TJ 4.054 0 Td [(;)4.3 ( al)2.6 (l)2.6 ( nodul)2.7 (es)-2 ( )11.3 (\()-6 (e)]TJ 0.002 Tw [(v)8.8 (en )]TJ 8.359 0 Td [(i)2.6 (nc)-2 (i)2.6 (dent)-6.6 (al)2.6 (om)-5.9 (as)8.9 (\))]TJ 0 Tc 0 Tw 6.978 0 Td ( )Tj -0.002 Tc 0.002 Tw -30.359 -1.37 Td [(s)-2 (houl)2.6 (d)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 3.217 0 Td [(hav)8.9 (e t)-6.6 (hi)2.6 (s)-2 ( as)-2 (s)-2 (e)10.6 (s)-2 (s)8.8 (m)-5.9 (ent)4.2 (;)-6.6 ( )11.3 (t)-6.6 (her)-5.9 (e)10.5 ( i)2.6 (s)-2 ( no)10.6 ( s)-2 (i)2.6 (z)8.9 (e c)-2 (ut)4.3 (o)10.5 (f)-6.6 (f)]TJ 0 Tc 0 Tw 19.543 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 277.92 206.04 Tm [(3,)-1.9 (46)]TJ 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 2.276 0 Td (48)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 301.44 202.08 Tm ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(T)-10.6 (he T)-10.5 (S)1.9 (H)2.6 ( )-10.6 (l)2.6 (ev)8.8 (el)2.6 (,)-6.6 ( )]TJ 0.007 Tw -25.457 -1.38 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2 (ound )11.2 (r)-5.9 (es)-2 (ul)2.6 (t)-6.6 (s)8.9 (,)-6.7 ( )0.5 (a)10.5 (nd c)-2 (l)13.5 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( f)-17.5 (ea)10.5 (t)-6.6 (ur)-5.9 (es)8.9 ( ar)-6 (e)10.5 ( us)-2 (ed)10.5 ( )]TJ [(t)4.3 (o )0.5 (det)-6.7 (e)10.6 (r)-6 (m)-5.9 (i)2.6 (ne w)13.5 (het)-6.6 (her)4.9 ( i)2.6 (s)-2 ( i)2.6 (t)4.2 ( )]TJ 0 -1.37 Td [(nec)-2 (es)-2 (s)-2 (ar)-5.9 (y)8.8 ( t)-6.6 (o)10.6 ( do )]TJ -0.005 Tc 0.005 Tw 7.315 0 Td [(f)-9.6 (in)-3.4 (e)]TJ 0 Tc 0 Tw 1.609 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(nee)10.5 (dl)2.6 (e )-10.6 (as)-2 (pi)2.7 (r)-6 (at)-6.6 (i)2.6 (on \()-5.9 (FN)2.6 (A)2 (\))-6 ( )]TJ 0.007 Tw 10.804 0 Td [(o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (h)10.5 (e nodul)2.7 (e or)4.9 ( w)13.4 (het)-6.6 (her)-6 ( )]TJ -20.065 -1.38 Td [(t)-6.6 (her)-6 (e)10.6 ( i)2.6 (s)-2 ( a l)2.6 (ow)13.5 ( r)-6 (i)2.6 (s)8.9 (k)-12.9 ( o)10.5 (f)-6.6 ( )11.3 (m)-6 (al)2.6 (i)2.6 (g)-11.2 (nanc)-2 (y)8.8 ( \()4.9 (s)-2 (ee )]TJ /TT2 1 Tf [(N)2.7 (odul)2.6 (e E)1.9 (v)-2 (al)13.5 (uat)-6.6 (i)2.6 (on)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 24.989 0 Td [(i)2.6 (n t)-6.6 (he)]TJ 0 Tc 0 Tw 2.435 0 Td ( )Tj -0.005 Tc 0.005 Tw 0.283 0 Td (NCCN)Tj 0 Tc 0 Tw ( )Tj -0.002 Tc -0.004 Tw -27.707 -1.37 Td [(G)-6.6 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( f)-17.5 (or)5 ( )]TJ 0.007 Tw [(T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d C)13.5 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a\))]TJ 0 Tc 0 Tw 15.174 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 194.16 145.32 Tm [(45,)-1.8 (49)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 211.44 141.36 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.005 Tc 0.005 Tw -17.304 -2.37 Td [(F)-2.7 (NA)]TJ 0 Tc 0 Tw 1.989 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(w)13.5 (i)2.6 (t)-6.6 (h )-10.6 (ul)2.6 (t)-6.6 (r)-6 (as)-2 (ound g)-11.3 (ui)13.5 (danc)-2 (e)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc -0.004 Tw 11.304 0 Td [(i)2.6 (s)-2 ( t)-6.6 (he )-10.6 (p)10.5 (r)-6 (oc)-2 (edur)]TJ 0.007 Tw 6.598 0 Td [(e)10.5 ( o)10.5 (f)-6.6 ( c)-2 (hoi)2.7 (c)-2 (e)10.5 ( )11.2 (f)-17.4 (o)10.5 (r)-6 ( ev)8.8 (al)2.6 (uat)-6.6 (i)2.6 (ng )]TJ -20.174 -1.38 Td [(s)-2 (us)-2 (pi)2.6 (c)-2 (i)2.6 (ous)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (d nodul)13.5 (es)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 155.64 103.92 Tm [(3,)-1.9 (45,)-1.9 (5)-17 (0)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 178.8 99.96 Tm ( )Tj 0.283 0 Td (D)Tj -0.002 Tc 0.007 Tw 0.717 0 Td [(at)-6.7 (a s)-2 (how)13.5 ( t)-6.6 (hat)4.2 ( )11.3 (hi)2.6 (g)-11.2 (her)4.9 ( )11.2 (T)-10.5 (S)1.9 (H)2.6 ( l)2.6 (ev)8.9 (el)2.6 (s)-2 ( ar)-6 (e )]TJ -15.065 -1.37 Td [(as)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (ed w)13.5 (i)2.6 (t)-6.6 (h an i)2.6 (nc)8.8 (r)-5.9 (e)10.5 (as)-2 (ed r)-6 (i)2.6 (s)8.9 (k)-2 ( )11.2 (f)-17.4 (o)10.5 (r)-6 ( di)13.5 (f)-6.6 (f)-6.7 (er)-5.9 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (e)10.5 (d )]TJ [(t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( )]TJ -0.005 Tc 0.005 Tw [(in)-3.4 ( )]TJ -0.002 Tc 0.007 Tw 0 -1.38 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d nod)10.5 (ul)2.6 (es)]TJ 12.576 0 Td [(,)-6.6 ( al)2.7 (t)-6.7 (hou)10.6 (g)-11.2 (h)10.5 ( )11.3 (T)-10.6 (S)1.9 (H)2.7 ( and )]TJ 8.87 0 Td [(t)4.3 (hy)8.9 (r)-6 (og)-11.2 (l)2.6 (obul)2.7 (i)2.6 (n \()4.9 (Tg)-11.2 (\))4.9 ( do no)10.5 (t)-6.6 ( )]TJ -0.004 Tw -21.446 -1.37 Td [(appear)-6 ( t)-6.6 (o )-10.6 (be)10.5 ( )-10.6 (us)-2 (e)10.6 (f)-17.5 (ul)13.5 ( f)-17.5 (o)10.5 (r)-5.9 ( )-10.6 (s)8.8 (c)-2 (r)-5.9 (eeni)2.7 (ng f)-17.5 (o)10.6 (r)-6 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )-10.7 (c)-2 (anc)8.8 (er)]TJ 0 Tc 0 Tw 22.554 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 275.64 58.44 Tm (51)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 1.431 0 Td (54)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 293.28 54.48 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(FN)2.6 (A)2 ( s)-2 (houl)2.6 (d be )]TJ -24.717 -1.38 Td [(c)-2 (ons)-2 (i)2.6 (der)-5.9 (ed i)2.6 (n pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)-8.3 (t)-6.6 (h no)10.5 (r)-5.9 (m)-6 (al)2.6 ( o)10.5 (r)-6 ( el)2.6 (ev)8.8 (at)-6.6 (ed )11.2 (T)-10.5 (S)12.8 (H)2.6 (,)-6.6 ( c)-2 (e)10.5 (r)-5.9 (t)-6.7 (ai)2.6 (n ul)2.6 (t)4.3 (r)-6 (as)-2 (ound)10.5 ( )]TJ 34.554 43 Td [(f)-6.6 (eat)-6.6 (u)10.5 (r)-5.9 (es)-2 (,)4.3 ( and )11.3 (c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( )0.5 (f)-17.5 (i)2.6 (nd)10.6 (i)2.6 (ng)-11.2 (s)-2 (.)4.3 ( FN)2.6 (A)1.9 ( o)10.6 (f)-6.7 ( c)-2 (l)2.6 (i)2.7 (ni)2.6 (c)-2 (al)2.6 (l)2.6 (y)8.9 ( s)-2 (i)2.6 (g)-11.2 (ni)2.6 (f)-17.5 (i)2.6 (c)-2 (an)10.5 (t)-6.6 ( o)10.5 (r)-5.9 ( s)-2 (us)-2 (pi)2.6 (c)-2 (i)2.6 (ous)8.9 ( )]TJ -0.011 Tc 0.011 Tw 0 -1.38 Td [(c)-11 (e)-9.3 (r)-15 (vi)-6.4 (c)]TJ -0.002 Tc 0.007 Tw 2.598 0 Td [(al)2.6 ( l)2.6 (y)8.8 (m)-5.9 (ph nodes)-2 ( s)-2 (h)10.5 (oul)2.6 (d al)2.6 (s)-2 (o be c)-2 (ons)-2 (i)2.6 (de)10.5 (r)-6 (ed i)13.5 (f)-6.6 ( i)2.6 (dent)-6.6 (i)13.5 (f)-17.5 (i)2.6 (ed)10.6 ( i)2.6 (n t)-6.6 (he)10.6 ( )]TJ -2.598 -1.37 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2 (ono)10.5 (g)-11.2 (r)-6 (aphi)2.6 (c)8.9 ( ev)8.9 (al)2.6 (uat)-6.6 (i)2.7 (on o)10.6 (f)-6.6 ( t)-6.6 (he)10.5 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d and)10.5 ( nec)8.9 (k)-2 (.)-6.6 ( U)2.6 (l)2.6 (t)4.3 (r)-6 (as)-2 (ound )11.3 (f)-6.7 (ea)10.5 (t)-6.6 (ur)-6 (es)8.8 ( )]TJ 0 -1.38 Td [(t)-6.6 (hat)4.3 ( i)2.6 (nc)-2 (r)-5.9 (eas)-2 (e)10.5 ( t)-6.6 (he)10.6 ( t)-6.6 (h)10.5 (r)-6 (es)-2 (ho)10.6 (l)2.6 (d )11.3 (f)-17.5 (or)5 ( FN)2.6 (A)1.9 ( ar)-6 (e)10.6 ( des)-2 (c)8.9 (r)-5.9 (i)2.6 (bed )11.3 (i)2.6 (n t)-6.6 (he al)13.5 (g)-11.2 (or)-5.9 (i)13.5 (t)-6.7 (hm)4.9 ( \()-5.9 (s)-2 (ee)10.5 ( )]TJ /TT2 1 Tf 0 -1.37 Td [(S)2 (onogr)-6 (aphi)2.6 (c)-2 ( Feat)-6.6 (u)10.5 (r)-6 (es)]TJ /TT0 1 Tf 0 Tc 0 Tw 9.804 0 Td ( )Tj -0.005 Tc 0.005 Tw 0.283 0 Td [(in)-3.4 ( )]TJ /TT2 1 Tf -0.002 Tc 0.007 Tw 1.054 0 Td [(N)2.6 (odul)2.6 (e E)2 (v)-2 (al)2.7 (uat)-6.5 (i)2.6 (on)]TJ 0 Tc 0 Tw ( )Tj /TT0 1 Tf -0.002 Tc -0.004 Tw 8.37 0 Td [(i)2.6 (n t)-6.6 (he)10.5 ( )]TJ -0.005 Tc -0.001 Tw 2.707 0 Td [(NCCN )-10.6 (G)-9.6 (u)-3.4 (id)-3.3 (e)-3.4 (lin)-3.3 (e)-3.4 (s)-5 ( f)-20.5 (o)7.5 (r)-9 ( )]TJ -0.002 Tc 0.002 Tw -22.217 -1.38 Td [(T)-10.6 (hy)]TJ 0.007 Tw 1.663 0 Td [(r)-6 (oi)2.6 (d C)2.6 (ar)-5.9 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (a)]TJ -0.004 Tw [(\))5 (.)-6.7 ( I)-6.6 (odi)2.6 (ne )-10.6 (123 \()]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 565.92 441.96 Tm (123)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 577.44 438 Tm [(I)-6.6 (\))-6 ( i)2.6 (m)-5.9 (a)10.5 (g)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( i)2.6 (s)8.9 ( r)4.9 (ec)-1.9 (om)-6 (m)-5.9 (en)10.6 (ded i)2.6 (n pa)10.6 (t)-6.7 (i)2.7 (ent)-6.6 (s)8.8 ( )]TJ -0.005 Tc 0.01 Tw -15.62 -1.37 Td [(wit)-9.6 (h)-3.4 ( lo)-3.3 (w)10.5 ( T)-13.5 (S)-1.1 (H.)-9.6 ( )]TJ 0 Tc 0 Tw 6.37 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -6.37 -2.38 Td [(S)2 (onog)-11.2 (r)-6 (aphi)2.6 (c)8.9 ( \()-6 (u)]TJ 0.002 Tw [(l)2.6 (t)4.2 (r)-5.9 (as)-2 (ound)]TJ 0 Tc 0 Tw 10.859 0 Td (\))Tj 0.337 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.272 0 Td [(f)-6.6 (eat)-6.6 (u)10.5 (r)-5.9 (es)-2 ( )]TJ 0.007 Tw 3.891 0 Td [(c)-2 (an)10.5 ( be)10.5 ( us)-2 (ed )11.3 (t)-6.6 (o)10.5 ( )]TJ [(pr)-5.9 (edi)2.6 (c)-2 (t)4.3 ( ei)2.6 (t)-6.6 (he)10.5 (r)-6 ( beni)13.5 (g)-11.3 (n o)10.5 (r)-5.9 ( )]TJ -0.004 Tw -15.359 -1.37 Td [(m)-6 (al)2.6 (i)2.6 (g)-11.2 (nan)10.5 (t)-6.6 ( t)-6.6 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(g)-11.2 (r)-6 (ow)13.5 (t)-6.6 (h o)10.5 (f)-6.6 ( a)10.5 ( nodul)2.6 (e ov)8.9 (er)-6 ( )11.3 (t)-6.7 (i)2.7 (m)-6 (e.)4.2 ( S)2 (i)2.6 (m)-6 (i)2.6 (l)2.7 (ar)-5.9 (l)2.6 (y)8.8 (,)-6.6 ( c)-2 (hoos)-2 (i)13.5 (ng w)13.4 (hi)2.6 (c)-2 (h nodul)2.6 (es)-2 ( ar)-6 (e )]TJ EMC ET endstream endobj 682 0 obj 26442 endobj %% Contents for page 67 %% Original object ID: 135 0 683 0 obj << /Length 684 0 R >> stream Q q BT /Xi65 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 684 0 obj 245 endobj %% Contents for page 68 %% Original object ID: 136 0 685 0 obj << /Length 686 0 R >> stream q endstream endobj 686 0 obj 2 endobj %% Contents for page 68 %% Original object ID: 11395 0 687 0 obj << /Length 688 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 740.28 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 756.84 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 760.56 23.76 Tm (5)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(appr)-6 (opr)-5.9 (i)2.6 (at)-6.6 (e)10.5 ( f)-17.5 (o)10.6 (r)-6 ( )]TJ 0.007 Tw 6.772 0 Td [(ac)8.8 (t)-6.6 (i)2.6 (v)8.9 (e )0.5 (s)-2.1 (ur)4.9 (v)8.9 (ei)-8.2 (l)2.6 (l)2.6 (anc)-2 (e)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 8.402 0 Td [(r)-6 (at)-6.6 (her)4.9 ( t)-6.6 (han)10.5 ( FN)13.5 (A)2 ( s)-2 (houl)2.6 (d be ba)10.6 (s)-2 (ed on)10.5 ( t)-6.6 (h)10.6 (e )]TJ -15.174 -1.38 Td [(pat)-6.6 (t)-6.6 (e)10.5 (r)-5.9 (n o)10.5 (f)-6.6 ( ul)2.6 (t)4.2 (r)-5.9 (as)-1.9 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Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)-6.6 (n s)-2 (el)2.6 (ec)-2 (t)-6.7 (ed c)-2 (a)10.5 (s)-2 (e)10.5 (s)-2 (,)-6.6 ( i)2.6 (t)4.3 ( )11.2 (m)-5.9 (ay)8.9 ( be r)-5.9 (eas)8.8 (onabl)2.6 (e )]TJ -0.004 Tw -14.641 -1.37 Td [(t)-6.6 (o f)-6.6 (ol)2.6 (l)2.6 (ow)13.5 ( )-10.6 (t)-6.6 (hes)-2 (e )-10.6 (nodul)2.6 (es)-2 ( w)2.6 (i)2.6 (t)-6.6 (h)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 12.467 0 Td [(s)-2 (er)-6 (i)2.6 (al)2.6 ( ul)2.6 (t)4.3 (r)-6 (as)-2 (ounds)8.9 (.)-6.6 ( )11.2 (D)2.6 (at)-6.6 (a i)2.6 (ndi)2.6 (c)-2 (at)-6.6 (e )11.2 (t)-6.6 (ha)10.5 (t)-6.6 ( ol)2.6 (der)4.9 ( )]TJ -12.467 -1.38 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h i)2.6 (nt)4.3 (r)-6 (at)-6.7 (hy)8.9 (r)-6 (oi)2.6 (dal)2.6 ( papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( )0.5 (m)-6 (i)2.6 (c)-2 (r)-6 (oc)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-6 (as)-2 ( )11.3 (m)-6 (ay)8.9 ( be )11.3 (g)-11.2 (ood)10.5 ( )]TJ 0 -1.37 Td [(c)-2 (andi)2.6 (dat)-6.6 (es)-2 ( )11.3 (f)-6.6 (or)5 ( an ac)8.9 (t)-6.6 (i)2.6 (v)8.9 (e s)-2 (ur)-6 (v)]TJ 12.685 0 Td [(ei)2.6 (l)2.6 (l)2.6 (anc)-2 (e appr)-6 (oac)-1.9 (h \()4.9 (r)4.9 (at)-6.6 (her)4.9 ( t)-6.6 (han)10.5 ( i)2.6 (m)4.9 (m)-5.9 (edi)2.6 (at)-6.7 (e )]TJ -12.685 -1.38 Td [(s)-2 (ur)4.9 (g)-11.3 (er)-5.9 (y)8.8 (\))-5.9 ( and)10.5 ( us)-2 (ual)2.6 (l)2.6 (y)8.8 ( s)-2 (how)13.4 ( no ev)8.8 (i)2.6 (denc)-2 (e of)-6.6 ( c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.7 (l)-8.3 (y)8.9 ( s)-2 (i)2.6 (g)-11.2 (ni)13.5 (f)-17.5 (i)2.6 (c)-2 (ant)4.3 ( di)2.7 (s)-2 (eas)-2 (e )]TJ 0 -1.37 Td [(pr)-6 (o)10.5 (g)-11.2 (r)-5.9 (es)-2 (s)-2 (i)2.6 (on)10.5 ( ov)8.9 (er)-6 ( at)4.2 ( l)2.6 (eas)-2 (t)4.3 ( 5 )11.3 (t)-6.6 (o 10)10.5 ( y)8.9 (ear)-6 (s)-2 ( o)10.6 (f)-6.6 ( )11.2 (f)-6.6 (ol)2.6 (l)2.6 (ow)]TJ 0 Tc 0 Tw 20.87 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(u)-11.2 (p.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 273.12 188.16 Tm (68)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 280.8 184.2 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (hes)-2 (e)10.6 ( obs)-2 (e)10.5 (r)-6 (v)8.9 (at)-6.6 (i)2.6 (ons)-2 ( )]TJ -23.587 -1.38 Td [(c)-2 (as)-2 (t)-6.7 ( doub)10.5 (t)4.3 ( on )11.3 (t)-6.6 (he c)-1.9 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( bene)10.6 (f)-17.5 (i)2.6 (t)4.3 ( o)10.5 (f)-6.6 ( di)2.6 (a)10.6 (g)-11.3 (nos)-1.9 (i)2.6 (ng \()-6 (a)10.5 (nd t)4.3 (r)-5.9 (eat)-6.7 (i)2.7 (n)10.5 (g)-11.2 (\))4.9 ( papi)2.6 (l)2.7 (l)2.5 (ar)-5.9 (y)8.8 ( )]TJ -0.004 Tw 0 -1.37 Td [(m)-6 (i)2.7 (c)-2 (r)-6 (oc)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( )-10.6 (i)2.6 (n )-10.7 (t)-6.5 (hes)-2 (e)10.5 ( s)-2 (el)2.6 (ec)-2 (t)-6.6 (ed gr)-6 (oups)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 226.68 157.8 Tm (69)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 234.36 153.84 Tm ( )Tj -0.002 Tc -0.004 Tw 0.272 0 Td [(O)-6.6 (t)-6.6 (he)10.6 (r)4.9 (s)-2 ( f)-17.4 (eel)2.6 ( t)-6.7 (ha)10.5 (t)-6.6 ( )-10.6 (s)-2 (u)10.5 (r)4.9 (g)-11.2 (er)-6 (y)8.9 ( )]TJ 0.007 Tw -19.37 -1.38 Td [(s)-2 (houl)2.7 (d be c)-2 (ons)-2 (i)2.6 (der)-5.9 (ed)10.6 ( )11.2 (f)-6.6 (or)4.9 ( s)-2 (el)2.7 (ec)-2 (t)4.3 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (as)8.9 ( w)13.5 (ho ar)-5.9 (e )]TJ 0 -1.37 Td [(45 y)8.9 (ear)-6 (s)-2 ( o)10.5 (f)-6.6 ( a)10.6 (g)-11.3 (e)10.6 ( or)4.9 ( ol)2.6 (der)-6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 142.8 127.44 Tm (70)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 150.48 123.48 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.002 Tw -11.783 -2.38 Td [(T)-10.6 (he)]TJ 0 Tc 0 Tw 1.717 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(N)2.6 (C)2.6 (C)2.6 (N)2.6 ( P)2 (anel)2.7 ( us)-2 (es)-2 ( )11.2 (r)5 (ec)-2 (om)-5.9 (m)-6 (en)10.5 (dat)-6.6 (i)2.6 (ons)-2 ( )11.3 (f)-6.6 (r)-6 (o)10.6 (m)4.9 ( s)8.8 (ev)8.9 (er)-5.9 (al)2.6 ( or)-6 (g)-11.2 (ani)2.6 (z)8.9 (at)-6.6 (i)2.6 (ons)-2 ( )11.2 (\()-5.9 (e)10.5 (g)-11.2 (,)4.2 ( )]TJ -2 -1.37 Td [(A)2 (m)-6 (er)-5.9 (i)2.6 (c)-2 (an )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.7 (d A)2 (s)-2 (s)-2 (o)10.5 (c)-2 (i)2.6 (at)-6.6 (i)2.6 (on [)-6.6 (A)12.9 (T)-10.6 (A)12.8 (])-6.6 (,)4.3 ( S)2 (oc)-2 (i)2.6 (et)-6.6 (y)8.8 ( o)10.5 (f)-6.6 ( R)2.6 (adi)2.7 (ol)2.6 (og)-11.2 (i)2.6 (s)-2 (t)-6.6 (s)-2 ( i)2.6 (n)10.5 ( )]TJ 0 -1.38 Td [(U)2.6 (l)2.6 (t)-6.6 (r)-5.9 (as)-2 (ound,)4.3 ( N)2.6 (C)2.6 (I)-6.6 (\))4.9 ( and )11.2 (t)-6.6 (he)10.5 (i)2.6 (r)-6 ( ex)8.9 (per)-6 (t)-6.6 (i)2.6 (s)-2 (e)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 16.185 0 Td [(w)13.5 (hen )11.3 (f)-17.5 (o)10.5 (r)-5.9 (m)-6 (ul)13.5 (at)-6.6 (i)2.6 (ng t)-6.6 (he)10.5 ( N)2.6 (C)2.6 (C)2.6 (N)2.6 ( )]TJ -16.185 -1.37 Td [(G)-6.6 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (or)5 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d no)10.5 (dul)2.6 (es)]TJ 0 Tc 0 Tw 13.185 0 Td ( )Tj -0.013 Tc 0.013 Tw 0.283 0 Td [(\()-17 (s)-13 (e)-11.3 (e )]TJ /TT2 1 Tf -0.002 Tc 0.007 Tw 2.217 0 Td [(N)2.6 (odul)2.6 (e E)2 (v)-2 (al)2.7 (uat)-6.6 (i)2.5 (on)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.005 Tc 0.01 Tw 8.37 0 Td [(in)-3.3 ( t)-9.6 (h)-3.3 (e)7.5 ( NCCN )]TJ -0.002 Tc -0.004 Tw 10.5 41.87 Td [(G)-6.6 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( f)-17.5 (or)4.9 ( T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (C)13.5 (ar)-5.9 (c)-2 (i)2.6 (nom)-5.9 (a\))4.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 575.64 517.92 Tm [(3,)-1.9 (49,)-1.9 (7)-17 (1)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 598.8 513.96 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (he N)2.7 (C)13.4 (C)2.6 (N)2.7 ( r)-6 (ec)-2 (om)4.9 (m)-6 (enda)10.5 (t)-6.6 (i)2.6 (ons)-1.9 ( )]TJ -17.837 -1.38 Td [(des)-2 (c)-2 (r)-6 (i)2.7 (be w)13.4 (hi)2.6 (c)-2 (h nodul)2.6 (es)-2 ( r)4.9 (eq)-11.2 (ui)2.6 (r)-5.9 (e)10.5 ( )11.3 (f)-17.5 (u)10.5 (r)-5.9 (t)-6.6 (he)10.5 (r)-5.9 ( as)8.9 (s)-2 (es)-2 (s)8.8 (m)-5.9 (e)10.5 (nt)-6.6 ( w)13.5 (i)2.6 (t)-6.6 (h FN)2.6 (A)1.9 ( and w)13.5 (hi)2.6 (c)-2 (h )]TJ 0 -1.37 Td [(c)-2 (an under)4.9 (g)-11.2 (o)10.5 ( ac)8.8 (t)-6.6 (i)2.7 (v)8.8 (e s)-2 (ur)-5.9 (v)8.8 (ei)2.6 (l)2.6 (l)2.6 (anc)-2 (e.)-6.6 ( I)-6.6 (n 2015)10.5 (,)-6.6 ( )11.3 (t)]TJ 0.002 Tw 18.674 0 Td (he )Tj -0.015 Tc 0.015 Tw 1.391 0 Td [(AT)-12.7 (A)-11 ( )]TJ -0.002 Tc 0.002 Tw 2.207 0 Td [(updat)-6.6 (ed)10.5 ( )]TJ -0.005 Tc 0.005 Tw 3.88 0 Td [(it)-9.6 (s)]TJ 0 Tc 0 Tw 1 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.272 0 Td [(g)-11.2 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )]TJ 0.007 Tw -27.424 -1.38 Td [(on t)-6.6 (he)10.6 ( m)-6 (ana)10.5 (g)-11.2 (e)10.5 (m)-5.9 (en)10.6 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.2 (t)-6.6 (h)]TJ 11.076 0 Td [(y)8.9 (r)-6 (oi)2.6 (d nodul)2.7 (es)-2 ( and t)-6.7 (hy)8.9 (r)-6 (oi)13.4 (d c)-2 (anc)-2 (er)4.9 (;)-6.6 ( )]TJ -0.016 Tc 0.016 Tw [(i)-0.6 (t)-20.6 (s)]TJ 0 Tc 0 Tw 15.957 0 Td ( )Tj -0.002 Tc 0.007 Tw -27.033 -1.37 Td [(c)-2 (om)-6 (pr)-5.9 (ehen)10.5 (s)-2 (i)2.6 (v)8.8 (e g)-11.2 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( al)2.6 (s)-2 (o di)2.6 (s)-2 (c)-2 (us)-2 (s)8.9 ( ul)2.7 (t)4.2 (r)-6 (as)-2 (oun)10.5 (d and FN)2.6 (A)2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 699.24 457.2 Tm (72)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 706.92 453.24 Tm ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(I)-6.6 (n)10.5 ( )-10.6 (2007)10.5 (,)-6.6 ( t)-6.6 (h)10.5 (e )]TJ 0.007 Tw -27.63 -1.38 Td [(N)2.6 (C)2.6 (I)-6.6 ( had a)10.5 ( c)-2 (on)10.6 (f)-6.6 (er)-5.9 (enc)-2 (e)10.5 ( on)10.6 ( us)-2 (i)2.6 (ng FN)2.6 (A)2 ( )11.3 (t)-6.7 (o )11.3 (m)-6 (ana)10.5 (g)-11.2 (e )11.2 (t)-6.6 (h)10.6 (y)8.8 (r)-5.9 (oi)2.6 (d nodul)2.6 (es)-2 (.)-6.6 ( )11.2 (T)-10.5 (he N)2.6 (C)2.6 (I)4.2 ( )]TJ 0 -1.37 Td [(g)-11.2 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( di)2.7 (s)-2.1 (c)-1.9 (us)-2 (s)8.9 ( w)13.5 (hi)2.6 (c)-2 (h)-11.2 ( nodul)2.6 (es)-2 ( s)-2 (h)]TJ [(oul)2.6 (d unde)10.5 (r)4.9 (g)-11.2 (o)10.5 ( FN)2.6 (A)2 ( and di)2.6 (s)-2 (c)-2 (us)8.9 (s)-2 ( )11.3 (t)-6.6 (he )]TJ 0 -1.38 Td [(FN)2.6 (A)2 ( r)-6 (es)-2 (ul)2.6 (t)-6.6 (s)8.9 ( \()-6 (i)2.7 (e,)4.3 ( c)-2 (a)10.5 (r)-6 (c)-2 (i)2.6 (nom)-6 (a,)4.3 ( beni)2.6 (g)-11.3 (n)]TJ 0.004 Tc -0.004 Tw 15.293 0 Td (\).)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 580.68 411.6 Tm [(45,)-1.8 (49)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 597.96 407.64 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (he)10.5 ( S)2 (oc)8.9 (i)2.6 (et)-6.6 (y)8.9 ( of)-6.6 ( R)2.6 (adi)2.6 (ol)2.6 (og)-11.2 (i)2.6 (s)-2 (t)4.3 (s)]TJ 0 Tc 0 Tw 12.076 0 Td ( )Tj -0.005 Tc 0.005 Tw 0.283 0 Td [(in)-3.4 ( )]TJ -0.002 Tc 0.007 Tw -30.12 -1.37 Td [(U)2.6 (l)2.6 (t)-6.6 (r)-5.9 (as)-2 (ound w)13.5 (r)-6 (ot)-6.6 (e)10.5 ( a c)-2 (ons)8.8 (ens)-2 (us)-2 ( s)8.9 (t)-6.6 (at)-6.6 (e)10.5 (m)-5.9 (ent)4.2 ( i)2.6 (n 2005)10.6 ( about)4.2 ( )0.5 (m)-6 (ana)10.5 (g)-11.2 (e)10.5 (m)-5.9 (en)10.5 (t)-6.6 ( o)10.6 (f)-6.7 ( )]TJ 0 -1.38 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d nodul)2.6 (es)-1.9 ( i)2.6 (dent)-6.6 (i)13.5 (f)-17.5 (i)2.6 (ed)10.5 ( at)4.3 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d ul)2.6 (t)4.3 (r)-5.9 (as)-2 (ono)10.5 (g)-11.2 (r)-5.9 (ap)10.5 (hy)8.9 (.)-6.6 ( I)-6.6 (t)-6.6 (s)8.9 ( r)-6 (e)10.6 (c)-2 (om)4.9 (m)-5.9 (enda)10.6 (t)-6.7 (i)2.7 (ons)-2 ( )]TJ 0 -1.37 Td [(des)-2 (c)-2 (r)-6 (i)2.7 (be w)13.4 (hi)2.6 (c)-2 (h nodul)2.6 (es)-2 ( )11.3 (s)-2 (houl)2.6 (d under)4.9 (g)-11.2 (o )]TJ -0.015 Tc 0.015 Tw [(F)-12.7 (N)-10.4 (A )]TJ -0.002 Tc 0.007 Tw 20.054 0 Td [(bas)8.9 (ed on nodul)2.6 (e )11.2 (s)-2 (i)2.6 (z)8.9 (e and )]TJ -0.004 Tw -20.054 -1.38 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2.1 (ound c)-2 (har)-5.9 (ac)8.9 (t)-6.6 (er)-5.9 (i)2.6 (s)8.9 (t)-6.6 (i)2.6 (c)-2 (s)-2 (,)-6.6 ( )-10.6 (and)10.5 ( )-10.6 (on c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)]TJ 0 Tc 0 Tw 18.163 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(f)-17.5 (ea)10.5 (t)-6.6 (ur)-5.9 (e)10.5 (s)-2 ( t)-6.6 (ha)10.5 (t)-6.6 ( )11.2 (m)-5.9 (i)13.5 (g)-11.2 (ht)4.3 ( pr)-5.9 (edi)2.6 (c)8.8 (t)-6.6 ( )11.3 (r)-5.9 (i)2.6 (s)-2.1 (k)-1.9 ( o)10.5 (f)-6.6 ( )]TJ -18.446 -1.37 Td [(m)-6 (or)-6 (bi)2.6 (di)2.6 (t)-6.6 (y)8.8 ( )11.3 (f)-6.6 (r)-6 (om)4.9 ( an undi)2.6 (a)10.5 (gnos)-2 (ed m)-6 (al)2.7 (i)13.4 (g)-11.2 (nanc)-2 (y)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 617.88 335.76 Tm (71)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 625.56 331.8 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(S)2 (us)-2 (pi)2.6 (c)-2 (i)2.6 (ous)-2 ( c)-2 (r)-6 (i)2.7 (t)-6.7 (er)-6 (i)2.7 (a)10.5 ( b)]TJ -0.011 Tc 0.011 Tw (y )Tj -0.002 Tc 0.007 Tw -20.261 -1.38 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2 (ound i)2.6 (nc)-2 (l)2.6 (ude i)2.6 (nc)8.8 (r)-5.9 (ea)10.6 (s)-2.1 (ed c)-2 (ent)4.2 (r)-5.9 (al)2.6 ( hy)8.9 (per)-6 (v)8.9 (as)-2 (c)-2 (ul)2.6 (ar)-5.9 (i)2.6 (t)-6.6 (y)8.9 (,)-6.7 ( )0.5 (hy)8.9 (poec)-2 (hoi)2.6 (c)-2 ( )0.5 (m)-6 (as)8.9 (s)-2 (,)4.3 ( )]TJ 0 -1.37 Td [(m)-6 (i)2.7 (c)-2 (r)-6 (oc)-2 (al)2.6 (c)-2 (i)13.5 (f)-17.5 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (ons)8.9 (,)-6.6 ( i)2.6 (n)10.5 (f)-17.5 (i)2.6 (l)2.6 (t)4.3 (r)4.9 (at)-6.7 (i)2.7 (v)8.8 (e m)-6 (ar)4.9 (g)-11.2 (i)2.6 (ns)-2 (,)4.3 ( and o)10.5 (t)-6.6 (he)10.6 (r)-6 ( )11.3 (f)-6.7 (eat)-6.7 (u)10.6 (r)-6 (es)-2 ( )11.2 (\()-5.9 (s)-2 (ee )]TJ /TT2 1 Tf 0 -1.38 Td [(S)2 (onogr)-6 (aphi)2.6 (c)-2 ( Feat)-6.6 (u)10.5 (r)-6 (es)]TJ /TT0 1 Tf 0 Tc 0 Tw 9.804 0 Td ( )Tj -0.005 Tc 0.005 Tw 0.283 0 Td [(in)-3.3 ( )]TJ /TT2 1 Tf -0.002 Tc 0.007 Tw 1.054 0 Td [(N)2.6 (odul)2.6 (e E)2 (v)-2 (al)2.7 (uat)-6.6 (i)2.7 (on)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.005 Tc 0.005 Tw 8.37 0 Td [(in)-3.3 ( )]TJ 0.01 Tw 1.043 0 Td [(t)-9.6 (h)-3.4 (e)7.6 ( NCCN G)-9.6 (u)-3.3 (id)-3.4 (e)-3.3 (lin)-3.4 (e)-3.3 (s)-5 ( )11.2 (f)-20.5 (o)7.6 (r)]TJ 0 Tc 0 Tw 10.967 0 Td ( )Tj -0.002 Tc 0.007 Tw -31.522 -1.37 Td [(T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d C)2.6 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-6 (a)]TJ 0 Tc 0 Tw (\))Tj 0.005 Tc -0.005 Tw 8.75 0 Td (. )Tj /TT1 1 Tf 0 Tc 0 Tw 0.554 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw -9.304 -2.37 Td [(A)2 (l)2.6 (t)-6.6 (houg)-11.2 (h)10.5 ( m)-5.9 (o)10.5 (r)-6 (e )11.3 (t)-6.7 (han 50)10.6 (%)6.6 ( o)10.6 (f)]TJ 0 Tc 0 Tw 12.076 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(al)2.6 (l)2.6 ( m)-6 (al)2.6 (i)2.6 (g)-11.2 (nan)10.5 (t)-6.6 ( no)10.6 (dul)2.6 (es)-2 ( )11.3 (ar)-6 (e as)-2 (y)8.9 (m)-6 (p)10.6 (t)-6.7 (om)-6 (a)10.6 (t)-6.6 (i)2.6 (c)-2 (,)4.2 ( t)-6.6 (he)10.5 ( )]TJ -12.359 -1.38 Td [(pr)-6 (et)-6.6 (es)8.9 (t)-6.6 ( p)10.5 (r)-6 (obabi)2.7 (l)2.5 (i)2.7 (t)-6.6 (y)8.8 ( of)-6.6 ( )11.2 (m)-5.9 (al)2.6 (i)2.7 (g)-11.3 (nanc)-2 (y)8.9 ( i)2.6 (n a)10.6 ( nodul)2.6 (e i)2.6 (nc)-2 (r)-6 (e)10.5 (as)-2 (es)-2 ( c)-2 (ons)-2 (i)2.6 (der)-6 (abl)2.6 (y)8.9 ( w)13.5 (hen )]TJ 0 -1.37 Td [(s)-2 (i)2.6 (g)-11.2 (ns)8.9 ( or)4.9 ( s)-2 (y)8.9 (m)-6 (pt)-6.6 (o)10.6 (m)-6 (s)-2 ( a)10.5 (r)-5.9 (e p)10.5 (r)-5.9 (es)-2 (ent)4.2 ( \()-6 (s)-2 (ee)10.5 ( )]TJ /TT2 1 Tf [(N)2.6 (odul)2.6 (e E)1.9 (v)-2 (al)13.4 (uat)-6.7 (i)2.7 (on)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.005 Tc 0.01 Tw 24.489 0 Td [(in)-3.3 ( t)-9.6 (h)-3.3 (e)7.5 ( NCCN )]TJ -0.002 Tc -0.004 Tw -24.489 -1.38 Td [(G)-6.6 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( f)-17.5 (or)4.9 ( T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (C)13.5 (ar)-5.9 (c)-2 (i)2.6 (nom)-5.9 (a\))4.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 575.64 203.28 Tm [(73,)-1.8 (74)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 592.92 199.32 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td 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adenom)-5.9 (at)-6.6 (ou)10.5 (s)-2 ( )]TJ EMC ET endstream endobj 688 0 obj 27176 endobj %% Contents for page 68 %% Original object ID: 137 0 689 0 obj << /Length 690 0 R >> stream Q q BT /Xi66 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 690 0 obj 245 endobj %% Contents for page 69 %% Original object ID: 138 0 691 0 obj << /Length 692 0 R >> stream q endstream endobj 692 0 obj 2 endobj %% Contents for page 69 %% Original object ID: 11396 0 693 0 obj << /Length 694 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 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an)10.6 (d m)-6 (ul)2.6 (t)-6.6 (i)2.6 (pl)2.6 (e)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 15.239 0 Td [(endoc)8.9 (r)-6 (i)2.6 (ne neo)10.6 (pl)2.6 (as)-2 (i)2.6 (a \()-5.9 (M)15.8 (E)1.9 (N)2.6 (\))-5.9 ( t)-6.6 (y)8.8 (pes)-2 ( 2A)2 ( or)4.9 ( )]TJ -15.239 -1.37 Td [(2B)1.9 (;)-6.6 ( 3\))5 ( ev)8.9 (i)2.6 (denc)-2 (e o)10.5 (f)-6.6 ( ot)-6.6 (he)10.5 (r)-5.9 ( )11.2 (t)-6.5 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)]TJ 0 Tc 0 Tw 17.13 0 Td <96>Tj -0.002 Tc 0.007 Tw 0.554 0 Td [(as)8.8 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (e)10.6 (d di)2.6 (s)-2 (eas)-2 (es)-2 ( o)10.5 (r)-5.9 ( )]TJ -17.685 -1.38 Td [(s)-2 (y)8.9 (ndr)-6 (om)-6 (es)-2 (,)4.2 ( s)-2 (uc)-2 (h)10.5 ( as)-2 ( hy)8.9 (p)10.5 (er)-6 (par)-6 (a)10.6 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (di)2.6 (s)-2 (m)-6 (,)-6.6 ( pheo)10.6 (c)8.8 (hr)-5.9 (om)-6 (oc)-2 (y)8.9 (t)-6.6 (o)10.5 (m)-6 (a,)4.2 ( m)-5.9 (a)10.5 (r)4.9 (f)-17.5 (anoi)2.6 (d)10.5 ( )]TJ 0 -1.37 Td [(habi)2.6 (t)-6.6 (us)-2 (,)-6.6 ( and)10.5 ( )11.3 (m)-6 (uc)-2 (os)-2 (al)2.6 ( ne)10.5 (ur)-5.9 (om)-5.9 (as)8.9 ( \()-6 (s)-2 (u)10.6 (gges)-2 (t)-6.6 (i)2.6 (v)8.9 (e o)10.5 (f)-6.6 ( M)4.9 (E)1.9 (N)2.7 (2B)2 (\))-6 (,)-6.6 ( w)13.5 (hi)2.6 (c)-2 (h m)-6 (a)10.6 (k)-12.9 (e)10.5 ( t)-6.6 (he)10.6 ( )]TJ -0.004 Tw 0 -1.38 Td [(pr)-6 (es)-2 (enc)-2 (e )-10.6 (o)10.5 (f)-6.6 ( m)-6 (edul)2.6 (l)]TJ 0.007 Tw 8.424 0 Td [(ar)-6 (y)8.9 ( c)8.8 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a )11.3 (m)-6 (o)10.6 (r)-6 (e l)2.6 (i)13.5 (k)-12.9 (el)2.7 (y)8.8 (;)-6.6 ( or)-6 ( )11.3 (4\))-5.9 ( )11.2 (t)-6.6 (he p)10.6 (r)-6 (es)-2 (enc)-2 (e)10.5 ( o)10.5 (f)-6.6 ( )]TJ -8.424 -1.37 Td [(s)-2 (us)-2 (pi)2.6 (c)-2 (i)2.6 (ous)-2 ( )11.3 (f)-17.5 (i)2.6 (ndi)2.7 (ngs)-1.9 ( de)10.5 (t)-6.6 (ec)8.8 (t)-6.6 (ed by)8.9 ( i)2.6 (m)-6 (a)10.5 (g)-11.2 (i)2.6 (n)10.6 (g)-11.3 (,)4.3 ( s)-2 (uc)-2.1 (h)10.6 ( as)-2 ( )11.3 (f)4.3 (oc)-2 (al)2.6 ( FD)2.6 (G)-6.6 ( up)10.5 (t)-6.6 (a)10.6 (k)-12.9 (e)10.5 ( on )]TJ 0 -1.38 Td [(P)2 (E)1.9 (T)-10.6 ( o)10.6 (r)-6 ( c)-2 (en)10.5 (t)-6.6 (r)-6 (al)13.4 ( hy)8.9 (per)-6 (v)8.9 (as)-2 (c)-2 (ul)2.6 (ar)-6 (i)2.6 (t)-6.6 (y)8.9 (,)-6.6 ( i)2.6 (r)-6 (r)-5.9 (e)10.5 (g)-11.2 (ul)2.6 (ar)4.9 ( bor)-5.9 (de)10.5 (r)-5.9 (,)4.2 ( )11.3 (and/)-6.6 (or)4.9 ( )]TJ 0 -1.37 Td [(m)-6 (i)2.7 (c)-2 (r)-6 (oc)-2 (al)2.6 (c)-2 (i)13.5 (f)-17.5 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (ons)8.9 ( on ul)2.6 (t)4.3 (r)-6 (as)-2 (ound)]TJ 0 Tc 0 Tw (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 185.76 396.48 Tm [(3,)-1.9 (76)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 199.2 392.52 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -16.196 -2.38 Td [(S)2 (om)-5.9 (e c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (i)2.6 (ans)-2 (,)-6.6 ( es)-1.9 (pe)10.5 (c)-2 (i)2.6 (al)2.6 (l)-8.2 (y)8.8 ( i)2.6 (n E)1.9 (ur)-6 (ope,)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 207.72 370.2 Tm (77)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 215.4 366.24 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(r)-6 (ec)-2 (o)10.5 (m)4.9 (m)-5.9 (e)10.5 (nd obt)-6.6 (ai)2.6 (ni)2.6 (ng s)-2 (e)10.6 (r)-6 (um)5 ( )]TJ -17.663 -1.37 Td [(c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n l)2.7 (ev)8.9 (el)2.6 (s)-2 ( f)-6.6 (r)-5.9 (om)4.9 ( al)2.6 (l)2.6 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d nod)10.5 (ul)2.6 (es)-2 ( t)-6.7 (o a)10.5 (s)-2 (s)-2 (es)-2 (s)8.8 ( )11.3 (f)-17.5 (o)10.6 (r)-6 ( )]TJ 0 -1.38 Td [(m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.6 (.)-6.6 ( H)2.6 (o)10.5 (w)13.5 (e)-11.2 (v)8.8 (er)-6 (,)-6.6 ( t)-6.6 (hi)2.6 (s)-2 ( i)2.6 (s)8.9 ( c)-2.1 (ont)4.3 (r)-5.9 (ov)8.9 (er)-5.9 (s)-2 (i)2.6 (al)2.6 ( )0.5 (i)2.6 (n t)-6.6 (he U)2.6 (ni)2.6 (t)-6.6 (ed)10.5 ( )0.5 (S)1.9 (t)-6.6 (a)10.5 (t)-6.6 (es)8.8 (,)-6.6 ( )]TJ 0 -1.37 Td [(es)-2 (pec)-2 (i)2.6 (al)2.6 (l)-8.2 (y)8.8 ( i)2.7 (n t)-6.6 (he abs)-2 (en)10.5 (c)8.9 (e o)10.5 (f)-6.6 ( c)-2 (on)10.5 (f)]TJ 14.413 0 Td [(i)2.6 (r)4.9 (m)-5.9 (a)10.5 (t)-6.6 (or)-5.9 (y)8.9 ( pent)-6.6 (a)10.5 (gas)-2 (t)-6.6 (r)-5.9 (i)2.6 (n )11.3 (s)-2 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (a)10.5 (t)-6.6 (i)2.6 (on t)-6.6 (es)8.8 (t)-6.6 (i)2.6 (n)10.6 (g)-11.2 ( )]TJ -14.413 -1.38 Td [(and bec)-2 (aus)-2 (e)10.5 ( i)2.6 (t)-6.6 ( )11.3 (m)-6 (ay)8.8 ( not)4.3 ( )11.3 (be c)-2 (os)-2 (t)4.3 ( e)10.5 (f)-6.6 (f)-6.6 (ec)8.9 (t)-6.6 (i)2.6 (v)8.9 (e.)-6.6 ( )11.3 (T)-10.6 (he A)12.9 (TA)1.9 ( i)2.6 (s)-2 ( e)10.5 (q)-11.2 (ui)2.6 (v)8.9 (oc)-2 (al)2.6 ( about)-6.6 ( )]TJ 0 -1.37 Td [(m)-6 (eas)-1.9 (ur)-5.9 (i)2.6 (n)10.5 (g s)-2 (er)-6 (u)10.6 (m)-6 ( )11.3 (c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.7 (n t)-6.6 (o s)8.9 (c)-2 (r)-5.9 (een)10.5 ( al)2.6 (l)2.7 ( pat)-6.7 (i)2.7 (ent)-6.6 (s)8.8 ( )11.3 (w)2.6 (i)2.6 (t)-6.6 (h t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d nodul)2.7 (es)-2 ( )11.3 (f)-6.6 (or)4.9 ( )]TJ 0 -1.38 Td [(m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.6 (.)]TJ 0 Tc 0 Tw 6.96 -0 0 6.96 128.16 279.12 Tm (3)Tj 11.04 -0 0 11.04 132 275.16 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 ( )11.2 (s)-2 (t)-6.6 (udy)8.9 ( s)-2 (how)13.5 (ed t)-6.6 (hat)4.2 ( c)-2 (al)2.6 (c)-2 (i)2.6 (t)4.3 (oni)2.6 (n s)-2 (c)-1.9 (r)-6 (eeni)2.7 (n)10.5 (g)-11.2 ( )11.2 (m)-5.9 (ay)8.9 ( be )]TJ -10.109 -1.37 Td [(c)-2 (os)-2 (t)-6.7 ( e)10.6 (f)-6.7 (f)-6.6 (e)10.6 (c)-2 (t)-6.6 (i)2.6 (v)8.9 (e i)2.6 (n t)-6.6 (he)10.5 ( U)2.6 (ni)2.6 (t)4.2 (ed S)1.9 (t)-6.6 (at)4.2 (es)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 189.96 264 Tm (78)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 197.64 260.04 Tm ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(H)2.6 (ow)13.4 (ev)8.9 (er)-5.9 (,)-6.6 ( f)-17.5 (al)2.6 (s)-2 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 6.924 0 Td [(pos)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (e c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n )]TJ -0.004 Tw -22.978 -1.37 Td [(r)-6 (eadi)2.6 (ng)-11.2 (s)8.8 ( )-10.6 (t)-6.6 (ha)10.5 (t)-6.6 ( c)-2 (an r)-5.9 (es)-2 (ul)2.6 (t)4.2 ( f)-6.6 (r)-6 (om)4.9 ( )-10.6 (m)-6 (i)2.7 (ni)2.6 (m)-5.9 (al)2.6 ( c)-2 (al)2.7 (c)-2.1 (i)2.7 (t)-6.6 (oni)2.6 (n )-10.6 (el)2.6 (ev)8.9 (at)-6.6 (i)2.6 (ons)-2 ( )-10.6 (hav)8.8 (e )]TJ 0.007 Tw 0 -1.38 Td [(t)-6.6 (r)-6 (adi)2.7 (t)-6.7 (i)2.7 (onal)2.6 (l)2.6 (y)8.9 ( been r)-5.9 (ul)2.6 (ed o)10.5 (ut)-6.6 ( w)13.5 (i)2.6 (t)-6.6 (h pent)-6.6 (a)10.5 (g)-11.2 (as)8.9 (t)-6.6 (r)-6 (i)2.6 (n)10.6 ( t)-6.6 (es)8.9 (t)-6.6 (i)2.6 (ng,)-6.6 ( and)10.5 ( pent)-6.6 (a)10.5 (g)-11.2 (as)8.9 (t)-6.6 (r)-6 (i)2.6 (n)10.6 ( i)2.6 (s)-2 ( )]TJ 0 -1.37 Td [(not)-6.6 ( av)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e i)2.7 (n t)-6.6 (he U)2.6 (ni)2.6 (t)-6.6 (e)10.5 (d S)2 (t)-6.6 (at)-6.7 (e)10.6 (s)-2 (.)4.2 ( S)2 (om)-5.9 (e)10.5 ( aut)-6.6 (ho)10.5 (r)-6 (s)8.9 ( )11.3 (hav)8.8 (e s)-2 (ugg)-11.2 (es)8.9 (t)-6.6 (ed )]TJ -0.005 Tc 0.005 Tw 0 -1.38 Td [(h)-3.3 (ig)-14.3 (h)]TJ 0 Tc 0 Tw 1.891 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(dos)-2 (e)10.5 ( c)-2 (al)2.6 (c)-2 (i)]TJ 4.424 0 Td [(um)4.9 ( i)2.6 (n)10.5 (f)-17.5 (us)-2 (i)13.4 (on as)-2 ( an)10.5 ( al)2.7 (t)-6.7 (er)4.9 (nat)-6.6 (i)2.6 (v)8.9 (e t)-6.6 (o p)10.5 (ent)-6.6 (a)10.5 (g)-11.2 (as)-2 (t)4.2 (r)-5.9 (i)2.6 (n s)8.9 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (at)-6.7 (i)2.7 (on )]TJ -6.652 -1.37 Td [(t)-6.6 (es)-2 (t)-6.6 (i)2.7 (n)10.5 (g)-11.2 ( i)2.6 (n)10.5 ( pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h m)4.9 (i)2.6 (ni)2.6 (m)-6 (al)2.6 ( c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.7 (n el)2.6 (ev)8.9 (at)-6.7 (i)2.7 (o)-11.3 (ns)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 277.44 188.16 Tm (79)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 285.12 184.2 Tm ( )Tj EMC /H2 <>BDC /TT1 1 Tf 0.009 Tc 0.007 Tw -23.696 -2.402 Td [(FN)-8.1 (A)35.4 ( )0.5 (R)2.7 (esul)-6.4 (t)-5.9 (s )]TJ 0 Tc 0 Tw 6.315 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw -6.315 -1.696 Td [(C)2.6 (y)8.9 (t)-6.6 (ol)2.6 (og)-11.2 (i)2.6 (c)-2 ( ex)8.9 (am)-6 (i)2.6 (nat)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( an FN)2.6 (A)1.9 ( s)-2 (pe)10.5 (c)-2 (i)2.6 (m)-6 (en )0.5 (i)2.5 (s)8.9 ( t)-6.6 (y)8.9 (pi)2.6 (c)-2 (al)2.6 (l)2.6 (y)8.9 ( c)-2 (at)-6.6 (eg)-11.2 (or)-5.9 (i)2.6 (z)8.8 (ed as)-2 (:)4.3 ( )]TJ 0 -1.37 Td [(c)-2 (at)-6.7 (e)10.6 (g)-11.2 (or)-5.9 (y)8.8 ( I)4.3 (:)4.2 ( nondi)2.6 (ag)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)8.8 ( )0.5 (or)4.9 ( uns)-2 (at)-6.6 (i)2.6 (s)8.8 (f)-6.6 (ac)-2 (t)-6.6 (o)10.5 (r)-5.9 (y)8.8 ( bi)2.6 (ops)-2 (y)8.8 (;)-6.5 ( c)-2.1 (at)-6.6 (e)10.5 (g)-11.2 (o)10.5 (r)-5.9 (y)8.8 ( I)4.3 (I)-6.6 (:)4.2 ( beni)2.6 (g)-11.2 (n)10.5 ( \()-5.9 (i)2.6 (e,)4.3 ( )]TJ -0.004 Tw 0 -1.38 Td [(nodul)2.6 (ar)-6 ( g)-11.2 (oi)2.6 (t)-6.6 (er)4.9 (,)-6.6 ( c)-2 (ol)2.6 (l)2.6 (oi)2.6 (d )-10.6 (g)-11.2 (oi)13.4 (t)-6.5 (er)4.9 (,)-6.6 ( )]TJ 0.007 Tw 12.804 0 Td [(hy)8.8 (per)-5.9 (pl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 (/)-6.6 (ade)10.5 (nom)4.9 (at)-6.6 (oi)2.7 (d nodul)2.6 (e,)4.2 ( )]TJ -12.804 -1.37 Td [(H)2.6 (as)-2 (hi)2.6 (m)-5.9 (ot)-6.6 <6f92>2.6 (s)-2 ( )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (di)2.6 (t)-6.6 (i)2.6 (s)-2 (\))-5.9 (;)-6.6 ( )11.3 (c)-2 (at)-6.6 (e)10.5 (g)-11.2 (or)-6 (y)8.9 ( I)4.2 (I)4.3 (I)-6.6 (:)4.2 ( at)-6.6 (y)8.8 (pi)2.6 (a o)10.5 (f)-6.6 ( un)10.6 (det)-6.7 (er)4.9 (m)-5.9 (i)2.6 (ned s)-2 (i)13.5 (g)-11.2 (ni)13.5 (f)-17.5 (i)2.6 (c)-2 (anc)-2 (e )]TJ 0 -1.38 Td [(\()-6 (A)2 (U)2.6 (S)2 (\))-6 ( or)4.9 ( )11.3 (f)-6.7 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( l)2.6 (es)-1.9 (i)2.5 (on o)10.6 (f)-17.5 ( unde)10.5 (t)-6.6 (er)4.9 (m)-5.9 (i)2.6 (ned s)-2 (i)13.5 (g)-11.2 (ni)13.4 (f)-17.4 (i)2.6 (c)-2 (a)10.5 (nc)-2 (e \()-6 (FLU)2.6 (S)2 (\))4.9 (;)-6.6 ( )11.3 (c)-2.1 (at)-6.6 (e)10.5 (g)-11.2 (o)10.5 (r)-5.9 (y)8.8 ( )]TJ -0.004 Tw 0 -1.37 Td [(I)-6.6 (V)2 (:)-6.7 ( f)-6.6 (ol)2.7 (l)2.6 (i)2.6 (c)-2 (ul)2.7 (ar)-6 ( )-10.6 (neopl)2.6 (as)-2 (m)4.9 ( )-10.6 (or)4.9 ( )-10.6 (s)-2 (us)-2 (pi)2.6 (c)-2 (i)2.6 (ous)-2 ( f)-6.6 (or)5 ( f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( neopl)2.6 (as)-2 (m)-5.9 ( \()-5.9 (i)2.6 (nc)-2 (l)2.7 (udes)-2 ( )]TJ 0 Tc 0 Tw 0 -1.38 Td (H)Tj 0.717 0 Td Tj -0.002 Tc 0.007 Tw 0.554 0 Td [(r)-6 (t)-6.6 (hl)2.6 (e c)-2.1 (el)2.6 (l)2.6 ( neopl)2.7 (as)-2 (m)4.9 (\))-5.9 (;)4.2 ( c)8.9 (at)-6.6 (e)10.5 (g)-11.2 (or)-6 (y)8.9 ( V)2 (:)4.2 ( s)-2 (us)-2 (pi)2.6 (c)-2 (i)2.6 (ous)-2 ( )11.2 (f)-6.6 (or)4.9 ( m)-6 (al)2.6 (i)2.6 (g)-11.2 (na)10.6 (nc)-2 (y)8.9 (;)-6.6 ( or)4.9 ( c)-2 (a)10.6 (t)-6.7 (e)10.6 (g)-11.3 (or)-5.9 (y)8.8 ( )]TJ 33.283 42.217 Td [(V)2 (I)-6.7 (:)-6.6 ( )11.3 (m)-5.9 (al)2.6 (i)2.6 (g)-11.2 (nan)10.5 (c)-2 (y)8.9 ( \()-5.9 (i)2.6 (nc)-2 (l)2.6 (udes)-2 ( )11.2 (papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 (,)-6.6 ( m)-5.9 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 (,)-6.6 ( anapl)2.6 (as)-2 (t)-6.7 (i)2.7 (c)-2 (,)-6.7 ( o)10.6 (r)-6 ( l)2.6 (y)8.9 (m)-6 (phom)-6 (a)10.6 (\))-6 (.)4.3 ( )]TJ -0.004 Tw 0 -1.38 Td [(T)-10.6 (hes)-2 (e)10.6 ( )-10.6 (di)2.6 (ag)-11.2 (no)10.5 (s)-2 (t)-6.6 (i)2.6 (c)-2 ( c)-2 (at)-6.6 (e)10.5 (g)-11.2 (o)10.5 (r)-6 (i)2.6 (es)-2 ( f)-17.5 (o)10.5 (r)-6 ( )-10.6 (FN)2.7 (A)12.8 ( )-10.6 (r)-6 (es)-2 (ul)2.6 (t)4.3 (s)-2 ( r)-6 (e)10.5 (f)-17.4 (l)2.6 (e)10.5 (c)-2 (t)-6.6 ( t)-6.6 (he )]TJ 0.007 Tw 24.272 0 Td [(2017)10.5 ( B)1.9 (et)-6.6 (hes)8.9 (da )]TJ -0.004 Tw -24.272 -1.37 Td [(S)2 (y)8.8 (s)-2 (t)-6.6 (em)-6 ( f)-17.5 (o)10.5 (r)-5.9 ( )-10.6 (R)2.6 (epo)10.5 (r)-5.9 (t)-6.7 (i)2.6 (n)10.6 (g)-11.2 ( T)-10.5 (h)10.5 (y)8.8 (r)-5.9 (oi)2.6 (d )-10.6 (C)2.6 (y)8.9 (t)-6.6 (opat)-6.6 (hol)2.6 (o)]TJ 0.009 Tc -0.009 Tw (gy)Tj 0 Tc 0 Tw 19.609 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 624.6 487.56 Tm (80)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 632.28 483.6 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(P)2 (at)-6.6 (hol)2.6 (og)-11.2 (y)8.8 ( and)10.6 ( )]TJ -20.87 -1.38 Td [(c)-2 (y)8.9 (t)-6.6 (opat)-6.6 (hol)2.6 (og)-11.2 (y)8.8 ( s)-2 (l)2.7 (i)2.6 (des)-2 ( s)-2 (ho)10.5 (ul)2.6 (d be r)-6 (ev)8.8 (i)2.6 (ew)13.5 (ed at)-6.6 ( t)-6.6 (he)10.6 ( t)4.2 (r)5 (eat)-6.7 (i)2.7 (ng i)2.6 (ns)-2 (t)-6.6 (i)2.6 (t)-6.6 (u)10.5 (t)-6.6 (i)2.6 (on )0.5 (by)8.9 ( a )]TJ 0 -1.37 Td [(pat)-6.6 (hol)2.6 (og)-11.2 (i)2.6 (s)8.8 (t)-6.6 ( w)13.5 (i)2.6 (t)-6.6 (h ex)8.9 (per)-6 (t)-6.6 (i)2.6 (s)8.9 (e i)2.7 (n t)-6.6 (he)10.5 ( di)2.6 (agnos)-2 (i)2.7 (s)-2 ( o)10.5 (f)-6.6 ( )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (d di)2.6 (s)-2 (or)-5.9 (der)-6 (s)8.9 (.)-6.6 ( A)2 (l)2.6 (t)-6.7 (hou)10.5 (g)-11.2 (h)10.5 ( )]TJ 0 -1.38 Td [(FN)2.6 (A)2 ( i)2.6 (s)-2 ( a v)8.9 (er)-5.9 (y)8.9 ( s)-2 (ens)-2 (i)2.6 (t)-6.6 (i)2.6 (v)]TJ 9.576 0 Td [(e t)4.3 (es)-2 (t)]TJ 0 Tc 0 Tw 2.446 0 Td <97>Tj -0.002 Tc 0.007 Tw [(pa)10.5 (r)-6 (t)-6.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 (l)2.6 (y)8.9 ( )11.2 (f)-17.5 (or)4.9 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a)]TJ 0 Tc 0 Tw <97>Tj -0.005 Tc 0.005 Tw -12.022 -1.37 Td [(f)-9.6 (a)-3.4 (ls)-5 (e)]TJ 0 Tc 0 Tw 2.109 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(ne)10.5 (g)-11.2 (at)-6.6 (i)2.6 (v)8.9 (e )]TJ 0.007 Tw 4.043 0 Td [(r)-6 (es)-2 (ul)13.5 (t)-6.6 (s)-2 ( a)10.5 (r)5 (e s)-2 (om)-6 (e)10.5 (t)-6.6 (i)2.6 (m)-5.9 (es)8.9 ( obt)-6.6 (ai)2.6 (ned)10.5 (;)-6.6 ( )11.3 (t)4.2 (her)-5.9 (e)10.5 (f)-17.5 (o)10.5 (r)-5.9 (e,)4.3 ( a )11.3 (r)-5.9 (eas)-2 (s)-2 (ur)-5.9 (i)2.6 (n)10.5 (g )]TJ -6.489 -1.38 Td [(FN)2.6 (A)2 ( s)-2 (houl)2.6 (d not)4.3 ( ov)8.9 (er)-5.9 (r)-6 (i)2.6 (de )11.3 (w)13.5 (or)-5.9 (r)-6 (i)2.6 (s)-2 (om)-6 (e c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( )]TJ -0.004 Tw [(or)-6 ( r)-6 (adi)2.6 (ogr)-6 (aphi)2.6 (c)-2 ( )]TJ -0.005 Tc 0.005 Tw [(f)-20.4 (in)-3.4 (d)-3.4 (in)7.5 (g)-14.2 (s)-5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 734.16 411.6 Tm [(81,)-1.8 (82)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 751.44 407.64 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -31.663 -2.37 Td [(M)15.8 (o)-11.2 (l)2.6 (ec)-2 (ul)2.6 (ar)-5.9 ( di)2.7 (ag)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)]TJ 0 Tc 0 Tw 9.087 0 Td ( )Tj -0.013 Tc 0.013 Tw 0.283 0 Td [(t)-17.6 (es)-13 (t)-6.7 (i)-8.4 (n)-11.4 (g)]TJ 0 Tc 0 Tw 2.935 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(t)-6.6 (o de)10.5 (t)-6.6 (ec)8.8 (t)-6.6 ( i)2.6 (ndi)2.6 (v)8.9 (i)2.6 (dual)2.6 ( m)-6 (ut)-6.6 (at)-6.6 (i)2.6 (ons)-2 ( )11.3 (\()-5.9 (e)10.5 (g)-11.2 (,)4.2 ( )]TJ /TT2 1 Tf -0.004 Tc 0.004 Tw [(BR)0.6 (AF)]TJ /TT0 1 Tf 0 Tc 0 Tw 17.783 0 Td ( )Tj -0.002 Tc 0.002 Tw -30.359 -1.38 Td [(V)2 (600E)]TJ 0.005 Tc -0.005 Tw 2.989 0 Td (, )Tj /TT2 1 Tf -0.004 Tc 0.004 Tw 0.565 0 Td [(R)0.6 (ET)-1.7 (/)-8.6 (PT)-1.7 (C)]TJ /TT0 1 Tf -0.006 Tc 0.006 Tw 4.261 0 Td (, )Tj /TT2 1 Tf -0.005 Tc 0.005 Tw 0.554 0 Td [(RA)-1 (S)]TJ /TT0 1 Tf 0.005 Tc -0.005 Tw 2.043 0 Td (, )Tj /TT2 1 Tf -0.004 Tc 0.004 Tw 0.554 0 Td [(PAX8)-2.4 (/)-8.6 (PPAR)]TJ /TT0 1 Tf 0 Tc 0 Tw 5.533 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [([)-6.6 (per)-6 (ox)8.9 (i)2.6 (s)-2 (om)4.9 (e pr)-5.9 (ol)2.7 (i)13.4 (f)-17.5 (er)-5.9 (a)10.5 (t)-6.6 (or)]TJ 0 Tc 0 Tw 10.467 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(ac)8.8 (t)-6.6 (i)2.6 (v)8.9 (at)-6.6 (ed )]TJ -27.587 -1.37 Td [(r)-6 (ec)-2 (ept)-6.6 (o)10.5 (r)-5.9 (s)-2 (])4.2 ( )]TJ 0.007 Tw 4.707 0 Td [(g)-11.2 (a)10.5 (m)-6 (m)-5.9 (a)10.5 (\))-5.9 ( o)10.5 (r)-6 ( pa)10.5 (t)-6.6 (t)-6.6 (e)10.5 (r)-5.9 (n )11.3 (r)-6 (ec)-2 (o)10.5 (g)-11.2 (ni)2.6 (t)-6.6 (i)2.6 (on app)10.5 (r)-6 (oac)8.9 (hes)-2 ( us)-2 (i)2.6 (n)10.5 (g)-11.2 ( )11.2 (m)-5.9 (ol)2.6 (ec)-2 (ul)2.6 (ar)-5.9 ( )]TJ -4.707 -1.38 Td [(c)-2 (l)2.6 (as)-2 (s)-2 (i)2.6 (f)-17.5 (i)2.6 (er)4.9 (s)-2 ( )11.3 (m)-6 (ay)8.9 ( be us)-2 (e)10.5 (f)-6.6 (ul)2.7 ( i)2.7 (n t)-6.6 (he)10.6 ( ev)8.9 (al)2.7 (uat)-6.7 (i)2.7 (on o)10.5 (f)-17.5 ( FN)2.6 (A)12.9 ( s)-2.1 (am)-6 (pl)2.6 (es)8.8 ( t)-6.6 (ha)10.5 (t)-6.6 ( a)10.5 (r)-5.9 (e )]TJ 0.002 Tw 0 -1.37 Td [(i)2.6 (ndet)-6.6 (er)-5.9 (m)-6 (i)2.6 (na)10.5 (t)-6.6 (e)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 6.315 0 Td [(t)-6.6 (o as)-2 (s)-2 (i)2.6 (s)8.9 (t)-6.6 ( i)2.6 (n)10.5 ( m)-6 (ana)10.6 (g)-11.3 (e)10.6 (m)-6 (ent)4.3 ( dec)-2 (i)2.6 (s)-2 (i)2.6 (ons)]TJ 0 Tc 0 Tw 15.239 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 645.96 324.72 Tm (83)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 1.448 0 Td (91)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 663.72 320.76 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(T)-10.6 (he )]TJ /TT2 1 Tf -0.004 Tc 0.004 Tw 2.011 0 Td [(BR)0.6 (AF)]TJ /TT0 1 Tf 0 Tc 0 Tw 2.652 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(V)2 (600E)2 ( )]TJ 0.007 Tw -28.663 -1.38 Td [(m)-6 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (on oc)-2 (c)-2 (u)10.5 (r)-6 (s)-2 ( i)2.7 (n)10.5 ( about)4.2 ( 45%)6.6 ( o)10.5 (f)-6.6 ( pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 20.337 0 Td [(pa)10.5 (pi)2.6 (l)2.7 (l)2.6 (ar)-6 (y)8.9 ( c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a and i)2.6 (s)8.9 ( )]TJ -0.004 Tw -20.337 -1.37 Td [(t)-6.6 (he m)-6 (os)-2 (t)4.2 ( )-10.6 (c)-2 (o)10.6 (m)-6 (m)-6 (on)10.5 ( m)-6 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (on.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 540.84 294.36 Tm (92)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 548.52 290.4 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(S)2 (om)-5.9 (e s)8.9 (t)-6.6 (udi)2.6 (es)-2 ( h)]TJ -0.004 Tw [(av)8.9 (e l)2.6 (i)2.7 (nk)-12.9 (ed t)-6.6 (he )]TJ /TT2 1 Tf -0.004 Tc 0.004 Tw 13.304 0 Td [(BR)0.6 (AF)]TJ /TT0 1 Tf 0 Tc 0 Tw 2.652 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(V)2 (600E)2 ( )]TJ 0.007 Tw -29.522 -1.38 Td [(m)-6 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (on t)-6.6 (o)10.5 ( poo)10.5 (r)-5.9 ( p)10.5 (r)-5.9 (o)10.5 (g)-11.2 (nos)8.8 (i)2.7 (s)-2 (,)-6.7 ( es)-2 (pec)-2 (i)2.6 (al)2.6 (l)2.6 (y)8.9 ( w)13.4 (hen oc)-2 (c)-2 (ur)-5.9 (r)-6 (i)2.6 (ng w)13.5 (i)2.6 (t)-6.6 (h )]TJ /TT2 1 Tf -0.005 Tc 0.005 Tw [(T)-2.7 (E)-1 (RT)]TJ /TT0 1 Tf 0 Tc 0 Tw 28.685 0 Td ( )Tj -0.002 Tc 0.007 Tw -28.685 -1.37 Td [(pr)-6 (om)-5.9 (o)10.5 (t)-6.6 (er)4.9 ( m)-6 (u)10.5 (t)-6.6 (at)-6.6 (i)2.6 (on)10.6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 497.4 264 Tm (93)Tj 0 Tc 0 Tw (-)Tj 0.013 Tc -0.013 Tw 1.431 0 Td (96)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 515.16 260.04 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(The c)-2 (hoi)2.6 (c)-2 (e o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (he p)10.5 (r)-6 (ec)-2 (i)2.6 (s)-2 (e )11.3 (m)-6 (ol)2.6 (ec)-2 (ul)2.6 (ar)-6 ( )11.3 (t)-6.6 (es)-2 (t)4.3 ( depends)8.9 ( )]TJ 0.002 Tw -10.261 -1.37 Td (on )Tj 0.007 Tw 1.391 0 Td [(t)-6.6 (he)10.6 ( c)-2 (y)8.8 (t)-6.6 (ol)2.6 (og)-11.2 (y)8.9 ( and )11.2 (t)-6.6 (he)10.5 ( c)8.9 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( q)-11.2 (ues)-2 (t)-6.6 (i)2.6 (on bei)2.6 (n)10.5 (g)-11.2 ( a)10.5 (s)8.9 (k)-2 (ed.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 664.92 248.88 Tm (97)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 1.431 0 Td [(1)-17 (00)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 686.52 244.92 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(I)-6.6 (ndet)-6.6 (er)4.9 (m)-6 (i)2.7 (nat)-6.6 (e )]TJ 0.007 Tw -25.783 -1.38 Td [(g)-11.2 (r)4.9 (oups)-2 ( i)2.6 (nc)-2 (l)2.6 (ude:)4.2 ( 1\))4.9 ( )11.3 (f)-17.5 (ol)2.7 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( o)10.6 (r)-6 ( H)2.6 4.9 (t)-6.6 (hl)2.6 (e c)-2 (el)2.6 (l)2.7 ( neopl)2.6 (as)8.9 (m)-5.9 (s)-2.1 (;)4.3 ( and 2)10.5 (\))-6 ( )]TJ -0.004 Tc 0.004 Tw 0 -1.37 Td [(AU)0.6 (S/)-8.6 (F)-1.7 (L)-2.3 (U)0.6 (S.)]TJ 6.96 -0 0 6.96 461.88 218.52 Tm (101)Tj 0 Tc 0 Tw 1.672 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.328 0 Td [(10)-17 (3)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 487.44 214.56 Tm ( )Tj 0.283 0 Td (T)Tj -0.002 Tc 0.007 Tw 0.62 0 Td [(he N)13.5 (C)2.6 (C)2.6 (N)2.6 ( P)2 (anel)2.6 ( )]TJ 0.002 Tw [(r)-5.9 (ec)-2 (om)4.9 (m)-6 (ends)8.9 ( )]TJ 0.007 Tw 13.402 0 Td [(m)-6 (ol)2.6 (ec)-2 (ul)2.6 (ar)4.9 ( di)2.7 (ag)-11.2 (no)10.6 (s)-2 (t)-6.6 (i)2.6 (c)-2 ( )]TJ 0.005 Tc -0.005 Tw -21.772 -1.38 Td [(te)6.7 (s)5 (ti)9.6 (n)17.5 (g)-4.2 ( )]TJ -0.002 Tc 0.007 Tw 3.217 0 Td [(f)-6.6 (or)4.9 ( ev)8.9 (al)2.6 (uat)-6.5 (i)2.5 (ng FN)2.6 (A)1.9 ( r)-5.9 (es)-2 (ul)2.6 (t)-6.6 (s)8.9 ( t)-6.6 (ha)10.5 (t)4.3 ( ar)-5.9 (e)10.5 ( s)-2 (us)-2 (pi)2.6 (c)-2 (i)2.6 (ous)-2 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )11.3 (f)-6.7 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( c)-2 (el)2.7 (l)2.6 ( )]TJ -3.217 -1.37 Td [(neopl)2.6 (as)-2 (m)-6 (s)-2 ( o)10.6 (r)-6 ( )]TJ -0.004 Tc 0.004 Tw [(AU)0.7 (S/)-8.6 (F)-1.7 (L)-2.3 (U)11.4 (S)]TJ 0 Tc 0 Tw ( )Tj -0.013 Tc 0.013 Tw 11.413 0 Td [(\()-17 (s)-13 (e)-11.3 (e )]TJ /TT2 1 Tf -0.002 Tc 0.007 Tw 2.217 0 Td [(N)2.6 (odul)2.6 (e E)2 (v)-2 (al)2.7 (uat)-6.6 (i)2.6 (on)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.005 Tc 0.01 Tw 8.37 0 Td [(in)-3.3 ( t)-9.6 (h)-3.3 (e)7.5 ( NCCN )]TJ -0.002 Tc 0.002 Tw [(G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )]TJ -22 -1.38 Td [(f)-6.6 (or)]TJ 0 Tc 0 Tw 1.163 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (\))-6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 520.68 172.92 Tm [(1)17.5 (04,)-19.1 (105)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 545.64 168.96 Tm ( )Tj 0.293 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -13.033 -2.37 Td [(H)2.6 (i)2.6 (s)-2 (t)-6.6 (or)-6 (i)2.6 (c)-2 (al)2.6 (l)2.6 (y)8.9 (,)-6.7 ( )0.5 (s)-2 (t)-6.6 (udi)2.7 (es)-2 ( hav)8.9 (e s)-2 (how)13.5 (n t)-6.6 (hat)4.2 ( m)-5.9 (ol)2.6 (ec)-2 (ul)2.7 (ar)4.9 ( di)2.6 (ag)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)-2 (s)-2 ( do)10.6 ( not)4.2 ( per)5 (f)-6.7 (or)4.9 (m)4.9 ( )]TJ -0.005 Tc 0.01 Tw 0 -1.38 Td [(w)10.5 (e)-14.3 (ll f)-20.4 (o)7.5 (r)-9 ( )]TJ 0.005 Tw [<48fc>-3.4 (r)1.9 (t)-9.5 (h)-3.4 (le)]TJ 0 Tc 0 Tw 6.652 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(c)-2 (el)2.6 (l)2.6 ( neop)10.5 (l)2.7 (as)-2 (m)-5.9 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 557.4 131.52 Tm [(102,)-1.8 (10)-17 (6,)-1.9 (1)-17 (07)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 596.04 127.56 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 ( 2015 publ)2.6 (i)2.6 (c)-1.9 (at)-6.6 (i)2.6 (on o)10.5 (f)-17.5 ( 134)10.5 ( pat)-6.6 (i)2.6 (en)10.6 (t)-6.7 (s)8.9 ( )]TJ -17.587 -1.37 Td [(l)2.6 (ook)-12.9 (ed a)10.6 (t)-6.6 ( )11.2 (t)-6.6 (he)10.5 ( per)4.9 (f)-6.6 (or)4.9 (m)-6 (anc)8.9 (e o)10.6 (f)-6.6 ( t)-6.7 (he)10.5 ( A)12.9 (f)-17.5 (i)2.6 (r)4.9 (m)-6 (a )11.3 (g)-11.3 (en)]TJ [(e)10.6 ( ex)8.9 (pr)-5.9 (es)-2 (s)-2 (i)2.7 (on c)-2 (l)2.6 (as)-2 (s)-2 (i)13.5 (f)-17.5 (i)2.6 (er)4.9 ( \()4.9 (G)-6.6 (E)2 (C)2.6 (\))4.9 ( )]TJ 0 -1.38 Td [(i)2.6 (n g)-11.3 (ui)2.6 (di)2.7 (n)10.5 (g)-11.2 ( )11.2 (m)-5.9 (ana)10.5 (g)-11.2 (em)-6 (en)10.6 (t)-6.6 ( )11.2 (o)10.6 (f)-17.5 ( FN)2.6 (A)2 ( di)2.6 (a)10.5 (g)-11.2 (nos)-2 (es)8.8 ( o)10.6 (f)-6.7 ( s)-2 (us)8.9 (pi)2.6 (c)-2 (i)2.6 (ous)-2 ( )11.2 (f)-17.5 (or)4.9 ( )]TJ -0.005 Tc 0.005 Tw [<48fc>-3.3 (r)1.9 (t)-9.7 (h)-3.3 (le)]TJ 0 Tc 0 Tw 29.533 0 Td ( )Tj -0.005 Tc 0.005 Tw 0.283 0 Td [(c)-5 (e)-3.4 (ll )]TJ -0.002 Tc 0.007 Tw -29.815 -1.37 Td [(neopl)2.6 (as)-2 (m)-6 ( o)10.5 (r)-5.9 ( A)1.9 (U)2.6 (S)2 ( c)-2 (onc)-2 (e)10.5 (r)4.9 (ni)2.6 (ng)-11.3 ( )11.3 (f)-6.6 (or)4.9 ( )]TJ -0.005 Tc 0.005 Tw [<48fc>-3.4 (r)1.9 (t)-9.6 (h)-3.3 (le)]TJ 0 Tc 0 Tw 17.891 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(c)-2 (el)2.6 (l)2.6 ( )-10.6 (neop)10.5 (l)2.7 (as)-2 (m)-5.9 (.)4.2 ( T)-10.6 (hi)2.6 (s)-2 ( )-10.6 (s)8.8 (t)-6.5 (udy)8.8 ( f)-17.5 (ound )]TJ 0.007 Tw -18.174 -1.38 Td [(t)-6.6 (hat)4.3 ( 86%)6.5 ( o)10.6 (f)-6.7 ( pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h s)-2 (us)-2 (pi)2.6 (c)-2 (i)2.6 (ous)-2 ( )11.2 (f)-17.4 (i)2.6 (ndi)2.6 (n)10.5 (g)-11.2 (s)8.9 ( on A)12.8 (f)-17.5 (i)13.5 (r)-6 (m)-5.9 (a)10.5 ( )11.3 (G)-6.6 (E)1.9 (C)2.6 ( had )]TJ 0 -1.37 Td [(unnec)-2 (es)-2 (s)-2 (ar)-5.9 (y)8.8 ( s)-2 (ur)4.9 (g)-11.2 (e)10.5 (r)-6 (y)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 510.24 55.68 Tm (107)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 521.76 51.72 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(H)2.6 (ow)13.4 (e)-11.2 (v)8.9 (er)-6 (,)-6.6 ( r)-6 (es)-2 (ul)2.7 (t)-6.7 (s)8.9 ( t)-6.6 (ha)10.6 (t)-6.6 ( w)13.5 (er)-6 (e p)10.5 (r)-5.9 (es)-2 (ent)-6.6 (ed)10.5 ( at)4.3 ( t)-6.6 (he)10.6 ( A)12.8 (T)-10.6 (A)2 ( )]TJ EMC ET endstream endobj 694 0 obj 27710 endobj %% Contents for page 69 %% Original object ID: 139 0 695 0 obj << /Length 696 0 R >> stream Q q BT /Xi67 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 696 0 obj 245 endobj %% Contents for page 70 %% Original object ID: 140 0 697 0 obj << /Length 698 0 R >> stream q endstream endobj 698 0 obj 2 endobj %% Contents for page 70 %% Original object ID: 11397 0 699 0 obj << /Length 700 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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(al)2.6 (i)2.6 (dat)-6.6 (ed i)2.6 (n 238 )11.2 (t)-6.6 (i)2.6 (s)-2 (s)-2 (ue s)-2 (a)10.5 (m)-5.9 (pl)2.7 (es)-2 ( and)10.5 ( )]TJ 0 -1.38 Td [(174 FN)2.6 (A)1.9 ( s)-2 (a)10.6 (m)-6 (pl)2.7 (es)-2 ( w)13.5 (i)2.6 (t)-6.6 (h )11.3 (k)-2 (now)13.5 (n s)]TJ -0.005 Tc -0.001 Tw 13.891 0 Td [(u)-3.3 (r)-9 (g)-14.2 (ic)-5 (a)-3.4 (l f)-9.7 (o)-3.3 (llo)-3.3 (w)]TJ 0 Tc 0 Tw 5.75 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up.)-6.6 ( A)2 ( 2018 publ)2.6 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (on on)10.5 ( t)-6.6 (h)10.5 (e )]TJ -19.978 -1.37 Td [(T)-10.6 (hy)8.9 (r)-6 (oS)1.9 (e)10.5 (q)-11.2 ( v)8.9 (3 G)-6.6 (e)10.6 (nom)-6 (i)2.6 (c)-2 ( C)13.5 (l)2.6 (as)-2 (s)-2 (i)2.6 (f)-17.5 (i)2.6 (er)4.9 ( r)-6 (epo)10.5 (r)-5.9 (t)-6.6 (ed)10.6 ( a )11.3 (s)-2 (ens)-2 (i)2.6 (t)4.2 (i)2.7 (v)-2 (i)2.6 (t)-6.6 (y)8.8 ( of)-6.6 ( 92.)-6.6 (9)10.5 (%)-4.3 ( )11.3 (\()-6 (95%)6.6 ( C)2.6 (I)4.2 (,)-6.6 ( )]TJ 0.002 Tw 0 -1.38 Td [(80.)-6.6 (52%)]TJ 0 Tc 0 Tw 3.391 0 Td <96>Tj -0.002 Tc 0.007 Tw 0.554 0 Td [(98)10.5 (.)-6.6 (50%)6.6 (\))-6 ( and)10.5 ( a )11.2 (s)-2 (pec)-2 (i)13.5 (f)-17.5 (i)2.6 (c)-2 (i)2.7 (t)-6.7 (y)8.9 ( o)10.5 (f)-17.4 ( 69)10.5 (.)-6.6 (3%)6.6 ( \()-5.9 (95)10.6 (%)-4.3 ( C)2.6 (I)4.2 (,)-6.6 ( 48)10.5 (.)-6.6 (21%)]TJ 0 Tc 0 Tw 23.109 0 Td <96>Tj -0.002 Tc -0.004 Tw 0.543 0 Td [(85.)-6.6 (67)10.6 (%)-4.3 (\))4.9 ( f)-6.6 (or)-6 ( )]TJ 0.002 Tw -27.598 -1.37 Td [(det)-6.6 (ec)-1.9 (t)-6.7 (i)2.7 (n)10.5 (g)-11.2 ( )]TJ -0.005 Tc 0.005 Tw 4.337 0 Td [<48fc>7.5 (r)-8.9 (t)-9.7 (h)-3.3 (le)]TJ 0 Tc 0 Tw 3.207 0 Td ( )Tj 0.005 Tw 0.272 0 Td [(ce)1.7 (l)4.6 (l)4.6 ( ca)12.5 (n)1.6 (ce)1.7 (r)-4 (s.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 171 305.4 Tm (109)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 182.52 301.44 Tm ( )Tj EMC /P <>BDC -0.018 Tc 0.018 Tw -14.402 -2.38 Td [(Mo)-27.2 (l)-13.4 (e)-16.4 (c)-18 (u)]TJ -0.002 Tc 0.007 Tw 3.207 0 Td [(l)2.6 (ar)-6 ( di)2.6 (ag)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (e)10.5 (s)-2 (t)4.3 (i)2.6 (ng)-11.2 ( )11.3 (m)-6 (ay)8.8 ( i)2.6 (nc)-2 (l)2.6 (ude m)-6 (ul)2.6 (t)-6.6 (i)13.4 (g)-11.2 (en)10.5 (e as)-2 (s)-2 (ay)8.8 (s)-2 ( \()-5.9 (e)10.5 (g,)-6.7 ( )11.3 (t)-6.6 (he )11.3 (G)-6.6 (E)1.9 (C)2.6 (\))5 ( )]TJ -3.207 -1.37 Td [(or)-6 ( i)2.6 (ndi)2.6 (v)8.9 (i)2.6 (dual)2.6 ( m)-6 (ut)-6.6 (at)-6.6 (i)2.6 (onal)2.6 ( a)10.5 (nal)2.6 (y)8.9 (s)-2 (i)2.6 (s)-2 (.)-6.6 ( )]TJ 0.002 Tw [(T)-10.6 (he )]TJ -0.004 Tc 0.004 Tw 16.62 0 Td [(G)-8.6 (EC)]TJ 0 Tc 0 Tw 2.163 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.272 0 Td [(m)-6 (eas)-2 (u)10.6 (r)-6 (es)-2 ( t)-6.6 (he )-10.6 (ex)8.8 (pr)-6 (es)-2 (s)-2 (i)2.6 (on )-10.6 (o)10.5 (f)-6.6 ( at)4.3 ( )]TJ -19.054 -1.37 Td [(l)2.6 (eas)-2 (t)-6.6 ( )-10.6 (140 g)-11.2 (e)10.5 (nes)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 104.4 248.88 Tm [(84,)-1.8 (110,)-19.1 (11)-17 (1)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 139.2 244.92 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)-6.6 (n addi)2.6 (t)-6.6 (i)2.6 (on t)-6.6 (o)10.5 ( )11.3 (t)-6.6 (hei)2.6 (r)-6 ( )0.5 (u)10.5 (t)-6.6 (i)2.6 (l)2.6 (i)2.6 (t)-6.6 (y)8.9 ( i)2.7 (n di)2.6 (ag)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)-2 (s)-2 (,)4.2 ( )11.3 (m)-5.9 (ol)2.6 (ec)-2 (ul)2.6 (ar)-5.9 ( )]TJ -10.761 -1.38 Td [(m)-6 (ar)4.9 (k)-12.9 (e)10.6 (r)-6 (s)-2 ( )11.3 (m)-6 (ay)8.9 ( dr)-6 (i)2.7 (v)8.8 (e dec)-2 (i)2.6 (s)-2 (i)2.6 (ons)-2 ( r)-6 (el)2.6 (at)-6.7 (ed)10.5 ( t)-6.6 (o)10.5 ( )11.3 (t)-6.6 (ar)4.9 (g)-11.3 (e)10.6 (t)-6.6 (ed )11.2 (t)-6.6 (h)10.6 (er)-5.9 (apy)8.8 ( )11.3 (f)-17.5 (or)4.9 ( adv)8.9 (anc)-2 (ed )]TJ 0 Tc 0 Tw 0 -1.37 Td (d)Tj -0.002 Tc 0.007 Tw 0.554 0 Td [(i)2.6 (s)-2 (eas)-2 (e and i)2.6 (n)10.6 (f)-17.5 (o)10.5 (r)-5.9 (m)4.9 ( el)2.6 (i)2.6 (g)-11.2 (i)2.6 (b)10.6 (i)2.6 (l)2.6 (i)2.6 (t)-6.6 (y)8.8 ( f)-17.4 (or)4.9 ( s)-2 (om)-6 (e)10.5 ( )0.5 (c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( t)-6.6 (r)-6 (i)2.6 (al)13.5 (s)-2 (.)-6.6 ( )11.2 (I)-6.6 (n addi)13.5 (t)-6.6 (i)2.6 (on,)-6.6 ( )11.3 (t)-6.6 (he )]TJ -0.554 -1.38 Td [(pr)-6 (es)-2 (enc)-2 (e o)10.5 (f)-6.6 ( )11.3 (s)-2 (om)-5.9 (e)10.5 ( m)-6 (u)10.6 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (ons)-2 ( m)-5.9 (ay)8.9 ( hav)8.8 (e pr)-5.9 (o)10.5 (g)-11.2 (no)10.6 (s)-2 (t)-6.6 (i)2.6 (c)8.8 ( i)2.6 (m)-5.9 (por)4.9 (t)-6.6 (anc)-2 (e)10.5 (.)]TJ 0 Tc 0 Tw 27.467 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -27.467 -2.37 Td [(A)2 ( m)-6 (i)2.6 (nor)-5.9 (i)2.6 (t)-6.6 (y)8.8 ( o)10.6 (f)-6.7 ( panel)2.7 (i)2.6 (s)-2 (t)-6.6 (s)8.8 ( ex)8.8 (pr)-5.9 (es)-2 (s)-2 (ed )11.3 (c)-2 (onc)-2 (er)-5.9 (n)10.5 ( r)-5.9 (e)10.5 (g)-11.2 (a)10.5 (r)-6 (di)2.6 (ng ac)-2 (t)-6.6 (i)2.6 (v)8.9 (e s)-2 (ur)-5.9 (v)8.8 (ei)2.6 (l)2.6 (l)2.6 (anc)-2 (e o)10.5 (f)-17.5 ( )]TJ 0 -1.38 Td [(f)-6.6 (ol)2.7 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( l)2.7 (es)-2 (i)2.6 (ons)-2 ( bec)-2 (aus)-2 (e)10.5 ( t)-6.6 (hey)8.9 ( w)13.5 (er)-5.9 (e per)-5.9 (c)-2 (ei)2.7 (v)8.8 (ed as)]TJ 0 Tc 0 Tw 21.609 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(pot)-6.6 (ent)-6.6 (i)2.6 (al)2.6 (l)2.6 (y)8.8 ( )0.5 (pr)-6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 6.543 0 Td [(m)-6 (al)2.6 (i)13.5 (g)-11.2 (nant)4.3 ( )]TJ 0.007 Tw -28.424 -1.37 Td [(l)2.6 (es)-2 (i)2.6 (ons)-2 ( w)13.4 (i)2.7 (t)-6.6 (h a v)8.8 (er)-6 (y)8.9 ( l)2.6 (o)-11.2 (w)13.5 (,)-6.6 ( but)-6.7 ( un)10.5 (k)-12.8 (now)13.4 (n,)-6.6 ( )11.3 (m)-6 (al)2.7 (i)2.6 (g)-11.3 (nan)10.5 (t)-6.6 ( p)10.5 (ot)-6.5 (ent)-6.6 (i)2.6 (al)2.6 ( i)13.5 (f)-6.6 ( not)4.3 ( s)-2 (ur)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 (l)2.6 (y)8.8 ( )]TJ 0 -1.38 Td [(r)-6 (es)-2 (ec)-1.9 (t)-6.7 (ed)10.5 ( \()-5.9 (l)2.6 (eadi)2.6 (n)10.6 (g)-11.3 ( )11.3 (t)-6.6 (o )11.2 (r)-5.9 (ec)-2 (o)10.6 (m)-6 (m)-6 (enda)10.5 (t)-6.6 (i)2.6 (ons)-2 ( )11.3 (f)-6.6 (or)5 ( ei)2.6 (t)-6.6 (her)4.9 ( a)10.6 (c)-2.1 (t)-6.6 (i)2.6 (v)8.9 (e s)-2 (ur)-5.9 (v)8.8 (ei)2.6 (l)2.6 (l)2.6 (anc)-2 (e or)-5.9 ( )]TJ 0 -1.37 Td [(c)-2 (ons)-2 (i)2.6 (der)-5.9 (i)2.6 (ng l)2.6 (obec)-1.9 (t)-6.7 (o)10.6 (m)-6 (y)8.9 ( i)2.6 (n l)2.6 (es)-2 (i)2.6 (ons)-2 ( c)-2 (l)2.6 (as)-2 (s)-2 (i)13.5 (f)-17.5 (i)2.6 (ed as)8.9 ( ben)10.6 (i)2.6 (g)-11.3 (n by)8.9 ( )11.3 (m)-6 (ol)2.6 (ec)-2 (ul)2.6 (ar)-6 ( )]TJ -0.005 Tc 0.01 Tw 0 -1.38 Td [(t)-9.6 (e)-3.4 (s)-5 (t)-9.6 (in)7.5 (g)-14.2 (\))1.9 (.)-9.6 ( Clin)-3.3 (i)]TJ -0.002 Tc 0.007 Tw [(c)-2 (al)2.6 ( r)-5.9 (i)2.6 (s)8.8 (k)-12.8 ( )11.2 (f)-6.6 (ac)8.9 (t)4.2 (or)-6 (s)-2 (,)4.3 ( s)-2 (ono)10.5 (g)-11.2 (r)-6 (aphi)2.6 (c)8.9 ( pat)4.2 (t)-6.6 (er)-6 (n)10.6 (s)-2.1 (,)-6.6 ( and)10.5 ( pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 ( p)10.6 (r)-6 (e)10.5 (f)-17.5 (e)10.6 (r)-6 (enc)-2 (e)10.6 ( )]TJ 0 -1.37 Td [(c)-2 (an hel)2.6 (p det)4.2 (er)4.9 (m)-6 (i)2.7 (ne w)13.4 (het)-6.6 (her)-6 ( ac)8.9 (t)-6.6 (i)2.6 (v)8.9 (e s)-2 (ur)-6 (v)8.9 (ei)2.7 (l)2.6 (l)2.6 (anc)-2 (e or)-6 ( l)2.6 (obec)-2 (t)-6.6 (o)10.5 (m)-5.9 (y)8.8 ( i)2.6 (s)-2 ( )]TJ -0.004 Tw 0 -1.38 Td [(appr)-6 (opr)-5.9 (i)2.6 (at)-6.6 (e)10.5 ( f)-17.5 (o)10.5 (r)-5.9 ( t)-6.7 (hes)-2 (e)10.5 ( )-10.6 (pat)-6.6 (i)13.4 (ent)-6.7 (s)]TJ 0 Tc 0 Tw 12.967 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.272 0 Td [(\()-6 (s)-2 (ee )]TJ /TT2 1 Tf 0.007 Tw 2.228 0 Td [(N)2.6 (odul)2.6 (e E)2 (v)8.8 (al)2.6 (uat)-6.6 (i)2.6 (on)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.005 Tc 0.005 Tw 8.359 0 Td [(in)-3.3 ( )]TJ 0.01 Tw 1.054 0 Td [(t)-9.6 (h)-3.4 (e)7.6 ( NCCN )]TJ -0.002 Tc -0.004 Tw -24.88 -1.37 Td [(G)-6.6 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( f)-17.5 (or)4.9 ( T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (C)13.5 (ar)-5.9 (c)-2 (i)2.6 (nom)-5.9 (a\))]TJ 0.005 Tc -0.005 Tw 15.174 0 Td (. )Tj 0 Tc 0 Tw 0.554 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw 18.826 41.87 Td [(R)2.6 (at)-6.6 (her)-6 ( )11.3 (t)-6.6 (han p)10.5 (r)-5.9 (oc)-2 (eedi)2.6 (n)10.5 (g)-11.2 ( )11.3 (t)4.2 (o i)2.6 (m)-6 (m)-5.9 (edi)2.6 (a)10.5 (t)-6.6 (e s)-2 (u)10.5 (r)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( r)-6 (es)8.8 (ec)-2 (t)-6.6 (i)2.6 (on t)-6.6 (o)10.5 ( ob)10.5 (t)-6.6 (ai)2.6 (n a )]TJ 0 -1.38 Td [(de)10.5 (f)-17.5 (i)2.6 (ni)2.6 (t)-6.6 (i)2.6 (v)8.8 (e di)2.7 (ag)-11.2 (nos)-2 (i)2.6 (s)-2 ( )]TJ -0.013 Tc 0.013 Tw 8.696 0 Td [(f)-28.5 (or)]TJ 0 Tc 0 Tw 1.174 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(t)-6.6 (h)10.5 (es)-2 (e i)2.6 (ndet)-6.6 (er)5 (m)-6 (i)2.6 (nat)-6.6 (e)10.5 ( FN)2.6 (A)2 ( c)8.9 (y)8.8 (t)-6.6 (ol)2.6 (og)-11.2 (y)]TJ 0 Tc 0 Tw 14.946 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(gr)-6 (oups)-2 ( \()4.9 (f)-17.4 (ol)2.6 (l)2.6 (i)2.7 (c)-2 (ul)2.6 (ar)-6 ( )]TJ 0.002 Tw -25.37 -1.37 Td [(l)2.6 (es)-2 (i)2.6 (ons)-2 (\))]TJ 0.007 Tw 3.435 0 Td [(,)-6.6 ( pa)10.6 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( c)-2 (an be)10.5 ( )11.3 (f)-6.6 (ol)2.6 (l)2.7 (ow)13.5 (ed )-10.5 (w)13.5 (i)2.6 (t)-6.6 (h )]TJ [(ac)-2 (t)-6.6 (i)2.6 (v)8.9 (e s)-2 (ur)-6 (v)8.9 (ei)2.7 (l)2.6 (l)2.6 (anc)-2 (e)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc -0.004 Tw 21.978 0 Td [(i)2.6 (f)-17.5 ( t)-6.6 (he )-10.6 (appl)2.6 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (on)10.5 ( )]TJ 0.007 Tw -25.413 -1.38 Td [(o)10.5 (f)-17.5 ( a)10.6 ( s)-2.1 (pec)-2 (i)13.5 (f)-17.5 (i)2.6 (c)-2 ( )11.3 (m)-6 (ol)2.6 (ec)-2 (ul)2.6 (ar)4.9 ( di)2.6 (ag)-11.3 (nos)8.9 (t)-6.6 (i)]TJ 0 Tc -0.006 Tw 14.13 0 Td [(c 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<0094>Tj /TT0 1 Tf -0.013 Tc 0.013 Tw 0.554 0 Td [(5%)-15.3 (\))-6.1 (.)]TJ 0 Tc 0 Tw 2.043 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(I)-6.6 (t)4.3 ( i)2.6 (s)-2 ( i)2.6 (m)-6 (por)4.9 (t)-6.6 (an)10.5 (t)-6.6 ( )11.3 (t)-6.6 (o no)10.5 (t)-6.6 (e )11.3 (t)-6.6 (hat)4.3 ( t)4.3 (he pr)-6 (edi)2.6 (c)-2 (t)-6.6 (i)2.6 (v)8.9 (e )0.5 (v)8.8 (al)2.6 (ue o)10.5 (f)-17.5 ( )]TJ 0.002 Tw -9.685 -1.38 Td [(m)-6 (ol)2.6 (ec)]TJ 0.007 Tw 2.663 0 Td [(ul)2.6 (ar)-5.9 ( di)2.6 (a)10.5 (g)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)-2 (s)-2 ( )11.3 (m)4.9 (ay)8.9 ( be s)-2 (i)2.6 (g)-11.2 (ni)13.4 (f)-17.4 (i)2.6 (c)-2 (an)10.6 (t)-6.7 (l)2.7 (y)8.8 ( i)2.6 (nf)-17.5 (l)2.6 (uen)10.6 (c)-2.1 (ed )0.5 (by)8.9 ( t)-6.6 (he)10.5 ( pr)-6 (e)]TJ 0 Tc 0 Tw (-)Tj 0.005 Tc -0.005 Tw 25.75 0 Td [(te)6.7 (s)15.8 (t )]TJ -0.002 Tc 0.007 Tw -28.413 -1.37 Td [(pr)-6 (obabi)2.6 (l)2.6 (i)2.7 (t)-6.7 (y)8.9 ( of)-6.6 ( di)2.6 (s)-2 (eas)-2 (e as)8.9 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (ed w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (he)10.5 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S)1.9 (t)-6.6 (a)10.6 (g)-11.2 (i)2.6 (ng )11.2 (M)15.8 (anua)-11.2 (l)2.6 ( \()-6 (s)-2 (ee )]TJ /TT2 1 Tf -0.004 Tw [(P)2 (r)-6 (o)10.5 (t)-6.6 (oc)-2 (ol)2.6 ( f)-6.6 (or)4.9 ( )]TJ 0.007 Tw 20.891 0 Td [(t)-6.6 (he)10.6 ( E)1.9 (x)-2 (am)-6 (i)2.6 (nat)-6.6 (i)2.6 (on)10.5 ( of)4.2 ( )]TJ EMC ET endstream endobj 700 0 obj 28461 endobj %% Contents for page 70 %% Original object ID: 141 0 701 0 obj << /Length 702 0 R >> stream Q q BT /Xi68 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 702 0 obj 245 endobj %% Original object ID: 9334 0 703 0 obj << /BaseFont /WYXKXF+ArialMT /DescendantFonts 2640 0 R /Encoding /Identity-H /Subtype /Type0 /ToUnicode 2641 0 R /Type /Font >> endobj %% Original object ID: 11398 0 704 0 obj [ 2643 0 R ] endobj %% Contents for page 71 %% Original object ID: 142 0 705 0 obj << /Length 706 0 R >> stream q endstream endobj 706 0 obj 2 endobj %% Contents for page 71 %% Original object ID: 11399 0 707 0 obj << /Length 708 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 740.28 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 756.84 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 760.56 23.76 Tm (8)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC /TT2 1 Tf -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(S)2 (pec)-2 (i)2.6 (m)-6 (ens)-2 ( F)11.2 (r)-6 (om)4.9 ( P)2 (at)-6.6 (i)2.6 (ent)4.3 (s)-2 ( )11.3 (W)-14.6 (i)2.6 (t)-6.6 (h)10.6 ( C)2.6 (ar)-5.9 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (as)-2 ( o)10.6 (f)-6.6 ( )11.2 (t)-6.6 (h)10.5 (e 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Tc 0 Tw 11.04 -0 0 11.04 60.12 351.12 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(R)2.6 (epeat)-6.6 ( FN)2.6 (A)2 ( w)]TJ 6.478 0 Td [(i)2.6 (l)-8.2 (l)2.6 ( not)-6.7 ( )11.3 (r)-5.9 (es)-2 (ol)2.6 (v)8.9 (e t)-6.6 (he di)2.7 (a)10.5 (g)-11.2 (nos)8.8 (t)-6.6 (i)2.6 (c)-2 ( di)2.6 (l)2.6 (em)-6 (m)-5.9 (a)10.5 (.)-6.6 ( H)2.6 (ow)13.5 (ev)8.8 (er)-6 (,)-6.6 ( )]TJ -10.076 -1.38 Td [(m)-6 (ol)2.6 (ec)-1.9 (ul)2.6 (ar)-6 ( di)2.6 (a)10.5 (g)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (e)10.5 (s)-2 (t)4.3 (i)2.6 (ng)-11.2 ( )11.2 (m)-5.9 (ay)8.8 ( be us)-2 (e)10.5 (f)-6.6 (ul)2.7 ( )11.2 (f)-6.6 (or)4.9 ( )11.3 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( c)-2 (el)2.6 (l)2.6 ( c)-2 (ar)4.9 (c)-2 (i)2.7 (nom)-6 (as)8.8 ( )]TJ 0.002 Tw 0 -1.37 Td [(\()-6 (s)-2 (ee )]TJ /TT2 1 Tf 0.007 Tw 2.228 0 Td [(N)2.6 (odul)2.6 (e E)2 (v)-2 (al)2.7 (uat)-6.6 (i)2.6 (on)]TJ /TT0 1 Tf 0 Tc 0 Tw 8.076 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (n t)-6.6 (he)10.5 ( N)2.6 (C)2.7 (C)2.6 (N)2.6 ( 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Tw 11.04 -0 0 11.04 323.4 233.88 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(P)2 (at)-6.6 (i)2.6 (ent)-6.6 (s)]TJ 0 Tc 0 Tw 3.609 0 Td ( )Tj -0.002 Tc 0.007 Tw -31.054 -1.38 Td [(w)13.5 (ho ar)-5.9 (e c)]TJ -0.005 Tc 0.005 Tw 4.326 0 Td [(lin)-3.3 (ic)-5 (a)-3.3 (ll)-11.3 (y)]TJ 0 Tc 0 Tw 3.196 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(eut)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d w)13.5 (i)2.6 (t)-6.6 (h a l)2.6 (ow)13.5 ( T)-10.6 (S)2 (H)2.6 ( and a)10.6 ( hot)4.2 ( nodul)2.7 (e on )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ -7.804 -1.37 Td [(i)2.6 (m)-5.9 (ag)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( )11.3 (s)-2 (houl)2.7 (d be ev)8.8 (al)2.6 (uat)-6.6 (ed and)10.5 ( t)4.3 (r)-6 (eat)-6.6 (ed)10.5 ( )11.3 (f)-17.5 (o)10.5 (r)-6 ( )11.3 (t)-6.6 (hy)8.8 (r)5 (ot)-6.6 (ox)8.9 (i)2.6 (c)-2 (os)-2 (i)2.6 (s)-2 ( as)-2 ( i)2.6 (ndi)2.6 (c)-2 (at)-6.6 (ed )]TJ 0 -1.38 Td [(ev)8.8 (en w)13.5 (he)]TJ [(n c)-12.9 (y)8.9 (t)-6.6 (ol)2.6 (og)-11.2 (y)8.8 ( i)2.6 (s)-2 ( s)-2 (u)10.6 (s)-2 (pi)2.6 (c)-2 (i)2.6 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(uat)-6.6 (i)2.6 (on)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.013 Tc 0.013 Tw 8.37 0 Td [(i)-8.4 (n )]TJ -0.002 Tc 0.007 Tw -31.967 -1.37 Td [(t)-6.6 (he N)2.6 (C)2.6 (C)2.6 (N)2.6 ( G)4.3 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( )11.2 (f)-17.4 (or)5 ( )11.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-6 (a)10.5 (\))-5.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 247.44 146.76 Tm [(2,)-1.9 (3)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 257.04 142.8 Tm ( )Tj 0.272 0 Td (T)Tj -0.002 Tc 0.007 Tw 0.609 0 Td [(hos)-2 (e )0.5 (pat)-6.7 (i)2.7 (ent)4.2 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h an )]TJ -22.033 -1.38 Td [(i)2.6 (nc)-2 (r)-6 (eas)-2 (ed o)10.5 (r)-5.9 ( no)10.5 (r)-5.9 (m)-6 (al)2.6 ( )11.3 (T)-10.6 (S)2 (H)13.4 ( and w)13.5 (i)2.6 (t)-6.6 (h c)-2 (y)8.9 (t)-6.6 (ol)2.6 (og)-11.2 (y)8.9 ( s)-2 (us)-2 (pi)2.6 (c)8.9 (i)2.6 (ous)-2 ( )11.2 (f)-17.5 (or)4.9 ( )11.3 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.7 (ar)-5.9 ( o)10.6 (r)-6 ( )]TJ 0 -1.37 Td [(H)2.6 -6 (t)-6.6 (hl)2.6 (e c)-2 (el)2.6 (l)2.6 ( neopl)2.6 (as)-2 (m)4.9 ( s)-2 (h)10.5 (oul)2.6 (d under)4.9 (g)-11.2 (o di)2.6 (a)10.5 (g)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)-2 ( l)13.4 (obec)-2 (t)-6.6 (om)-5.9 (y)8.9 ( o)10.5 (r)-6 ( )11.3 (t)-6.6 (ot)-6.6 (al)2.6 ( )]TJ 0 -1.38 Td [(t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 (,)-6.6 ( depe)10.6 (ndi)2.6 (ng on pa)10.6 (t)-6.6 (i)2.6 (ent)]TJ 0 Tc 0 Tw 16.076 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(p)10.5 (r)-5.9 (e)10.5 (f)-17.5 (e)10.5 (r)-5.9 (enc)-2 (e)10.5 ( u)10.5 (nl)2.6 (es)-2 (s)-1.9 ( m)-5.9 (ol)2.6 (ec)-2 (ul)2.6 (ar)4.9 ( )]TJ -16.359 -1.37 Td [(di)2.6 (ag)-11.2 (nos)-2 (t)-6.6 (i)2.6 (c)8.9 ( t)-6.6 (es)8.9 (t)-6.6 (i)2.6 (n)10.5 (g)-11.2 ( p)10.5 (r)-5.9 (edi)2.6 (c)-2 (t)4.3 (s)-2.1 ( a l)2.6 (ow)13.4 ( r)-5.9 (i)2.6 (s)8.9 (k)-12.9 ( o)10.5 (f)-6.6 ( )11.3 (m)-6 (al)2.6 (i)2.6 (g)-11.2 (nanc)8.9 (y)8.9 (.)-6.6 ( )]TJ 0 Tc 0 Tw ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw 0 -2.37 Td [(I)-6.6 (n pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h )11.3 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( or)-6 ( H)2.6 4.9 (t)-6.6 (hl)2.6 (e c)-2 (el)2.6 (l)2.6 ( neopl)2.6 (as)8.8 (m)-5.9 ( )11.3 (on FN)2.6 (A)1.9 ( w)13.5 (ho ar)-6 (e )]TJ 0 -1.38 Td [(s)-2 (el)2.6 (ec)-2 (t)-6.6 (ed )11.3 (f)-6.6 (or)5 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d s)-2 (u)10.5 (r)5 (ger)-6 (y)8.9 ( i)2.6 (n or)-6 (der)5 ( t)-6.6 (o)10.6 ( ob)10.5 (t)-6.6 (ai)2.6 (n a d)10.5 (e)10.5 (f)-17.5 (i)2.7 (ni)2.6 (t)-6.6 (i)2.6 (v)8.9 (e di)2.6 (ag)-11.3 (nos)-2 (i)2.6 (s)-2 (,)-6.6 ( )11.2 (t)-6.6 (o)10.5 (t)-6.6 (al)2.6 ( )]TJ -0.004 Tw 34.554 42.87 Td [(t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( )-10.6 (i)2.6 (s)-2 ( r)-6 (ec)-2 (o)10.5 (m)-6 (m)5 (end)]TJ [(ed f)-17.5 (o)10.5 (r)-5.9 ( )]TJ 0.007 Tw 15.576 0 Td [(bi)2.6 (l)2.6 (at)-6.6 (er)-6 (al)13.4 ( di)2.6 (s)-2 (eas)-2 (e,)-6.6 ( uni)2.6 (l)2.6 (at)-6.6 (e)10.6 (r)-6 (al)2.7 ( di)2.6 (s)-2 (eas)-2 (e )]TJ -15.576 -1.38 Td [(g)-11.2 (r)4.9 (eat)-6.6 (e)10.5 (r)-5.9 ( )11.2 (t)-6.6 (han 4)10.5 ( c)8.9 (m)-6 ( )11.3 (\()-6 (es)-2 (pec)8.9 (i)2.6 (al)2.6 (l)-8.2 (y)8.8 ( i)2.6 (n m)-6 (en\))-5.9 (,)]TJ 0 Tc 0 Tw 16.674 0 Td ( )Tj 0.283 0 Td (i)Tj -0.002 Tc 0.007 Tw 0.217 0 Td [(nv)8.8 (as)-2 (i)2.6 (v)8.9 (e c)-2 (a)-11.2 (nc)-1.9 (er)-6 (,)4.3 ( m)-6 (e)10.6 (t)-6.6 (as)8.9 (t)-6.6 (at)-6.6 (i)2.6 (c)-2 ( )11.3 (c)-2 (anc)-2 (er)4.9 (,)-6.6 ( )]TJ -17.174 -1.37 Td [(or)-6 ( i)13.5 (f)-6.6 ( t)-6.6 (he)10.5 ( pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 ( p)10.5 (r)-5.9 (e)10.5 (f)-17.5 (e)10.5 (r)-5.9 (s)-2 ( )11.3 (t)-6.7 (h)10.6 (i)2.6 (s)-2 ( appr)-5.9 (oac)-2 (h)10.5 (.)-6.6 ( A)1.9 (n)10.6 ( FN)2.6 (A)1.9 ( )0.5 (t)-6.7 (ha)10.5 (t)-6.6 ( y)8.9 (i)2.6 (el)2.6 (ds)-2 ( i)2.6 (ns)-2 (u)10.6 (f)-6.6 (f)-17.5 (i)2.6 (c)-2 (i)2.6 (ent)4.3 ( )]TJ 0 -1.38 Td [(c)-2 (el)2.6 (l)2.6 (ul)2.6 (ar)-6 ( m)-5.9 (at)-6.6 (e)10.6 (r)-6 (i)2.6 (al)2.7 ( )11.2 (f)-17.4 (o)10.5 (r)-6 ( di)2.6 (a)10.5 (gnos)-2 (i)2.6 (s)-2 ( and i)2.6 (s)-2 ( )11.3 (s)-2 (ol)2.6 (i)2.6 (d s)-2 (houl)2.6 (d )11.3 (be r)-5.9 (epea)10.5 (t)-6.6 (ed,)4.3 ( bec)-2 (aus)-2 (e)10.5 ( )]TJ 0 -1.37 Td [(appr)-6 (ox)8.8 (i)2.6 (m)-5.9 (at)-6.6 (el)2.6 (y)8.9 ( 50%)-4.3 ( o)10.5 (f)-6.6 ( s)-2 (u)10.5 (bs)-2.1 (eq)-11.2 (uen)10.5 (t)-6.6 ( s)-2 (p)10.5 (ec)-2 (i)2.6 (m)-6 (ens)8.9 ( ar)-6 (e)10.5 ( ade)10.6 (q)-11.3 (uat)-6.6 (e)10.6 ( t)-6.7 (o)10.6 ( as)-2 (s)-2 (i)13.5 (g)-11.2 (n a)10.6 ( )]TJ 0.002 Tw 0 -1.38 Td [(di)2.6 (ag)-11.2 (nos)-2 (i)]TJ -0.004 Tw 3.717 0 Td [(s)-2 ( \()-6 (s)-2 (ee )]TJ /TT2 1 Tf 0.007 Tw 3 0 Td [(N)2.6 (odul)2.6 (e E)12.8 (v)-2 (al)2.6 (uat)-6.6 (i)2.6 (on)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 8.359 0 Td [(i)2.6 (n t)-6.6 (he)10.5 ( N)2.6 (C)2.7 (C)2.6 (N)2.6 ( G)4.2 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( f)-17.5 (o)10.6 (r)-6 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0.002 Tw -15.076 -1.37 Td [(C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a\))4.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 465 426.84 Tm (74)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 472.68 422.88 Tm ( )Tj 0.005 Tc -0.005 Tw 0.283 0 Td (In)Tj 0 Tc 0 Tw 0.837 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(p)10.5 (at)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h s)-2 (er)-5.9 (i)2.6 (al)2.6 ( nondi)2.6 (ag)-11.2 (nos)8.9 (t)-6.6 (i)13.4 (c)-2 ( as)-2 (pi)2.7 (r)-6 (a)10.5 (t)-6.6 (e)]TJ -0.013 Tc 0.018 Tw [(s)-13 (,)-6.8 ( 5)-11.3 (%)-4.4 ( of)-17.6 ( )]TJ -0.002 Tc 0.007 Tw -7.533 -1.38 Td [(w)13.5 (om)-5.9 (en and 30%)6.6 ( o)10.5 (f)-6.6 ( m)-5.9 (en)10.5 ( )11.3 (m)-5.9 (ay)8.9 ( pr)-5.9 (ov)8.9 (e t)-6.6 (o)10.6 ( hav)8.8 (e m)-6 (al)2.6 (i)2.6 (gnant)-6.6 ( nodul)2.6 (es)8.8 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 712.68 411.6 Tm (122)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 724.2 407.64 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(N)2.6 (odul)2.6 (es)-12.8 ( )]TJ 0.007 Tw -29.196 -1.37 Td [(y)8.9 (i)2.6 (e)-11.2 (l)2.6 (di)2.7 (ng)-11.2 ( beni)2.7 (g)-11.3 (n)10.6 ( c)-2 (y)8.8 (t)-6.6 (ol)2.6 (og)-11.2 (y)8.9 ( )11.3 (do not)4.2 ( r)-5.9 (e)10.5 (q)-11.2 (ui)2.6 (r)-5.9 (e)10.5 ( 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(ons)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 506.64 350.88 Tm (123)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 518.16 346.92 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(S)2 (i)2.6 (z)8.8 (e c)-2 (hang)-11.2 (es)-2 ( s)-2 (houl)2.6 (d)10.5 ( be )11.3 (g)-11.3 (r)4.9 (eat)-6.5 (e)10.5 (r)-6 ( )11.3 (t)-6.6 (han 2)10.5 ( m)5 (m)4.9 ( and )]TJ -10.533 -1.37 Td [(as)-2 (s)-2 (es)-2 (s)-2 (ed by)8.8 ( di)2.6 (r)-6 (ec)8.9 (t)-6.6 ( c)-2 (o)10.6 (m)-6 (p)10.5 (ar)-6 (i)2.6 (s)-2 (on o)10.5 (f)-6.6 ( i)2.6 (m)-6 (a)10.5 (g)-11.2 (es)8.9 (.)-6.7 ( )33 (W)-36.2 (h)10.5 (en)10.5 ( )11.3 (a di)2.6 (ag)-11.2 (nos)-2 (i)2.6 (s)8.9 ( o)10.5 (f)-6.6 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.38 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( i)2.6 (s)-2 ( pr)-5.9 (o)10.5 (m)-6 (p)10.6 (t)-6.6 (l)2.6 (y)8.9 ( es)-2 (t)-6.6 (abl)2.6 (i)2.6 (s)-2 (hed us)-2 (i)2.6 (ng FN)2.7 (A)1.9 (,)4.3 ( t)-6.6 (he)10.5 ( t)-6.6 (u)10.6 (m)-6 (or)5 ( i)2.6 (s)-2 ( o)10.5 (f)-6.6 (t)-6.6 (en)10.5 ( )0.5 (c)-2.1 (on)10.5 (f)-17.5 (i)2.6 (ned)10.5 ( )]TJ 0 -1.37 Td [(t)-6.6 (o )11.3 (t)-6.6 (he )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d or)4.9 ( has)-2 ( )11.3 (m)-6 (et)4.3 (as)-2 (t)-6.6 (as)-2 (i)2.6 (z)8.9 (ed onl)2.6 (y)8.9 ( t)-6.6 (o r)-6 (e)10.5 (g)-11.2 (i)2.6 (ona)10.5 (l)2.7 ( nodes)-2 (;)]TJ 0 Tc 0 Tw 25.272 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(t)-6.6 (hus)8.9 (,)-6.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( )]TJ -25.543 -1.38 Td [(c)-2 (an be c)-2 (u)10.5 (r)-5.9 (ed.)4.2 ( H)2.7 (ow)13.5 (ev)8.9 (er)-6 (,)-6.6 ( as)-2 ( m)-5.9 (any)8.9 ( as)8.9 ( 5%)6.6 ( o)10.5 (f)-6.6 ( pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( )]TJ 0 -1.37 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( and up)10.5 ( t)-6.6 (o)10.5 ( 10)10.5 (%)-4.3 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (hos)-2 (e pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (i)2.7 (t)-6.7 (h )11.3 (f)-6.6 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( or)-5.9 ( H)2.6 5 (t)-6.6 (hl)2.6 (e c)-2 (el)2.6 (l)2.7 ( )]TJ 0 -1.38 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( hav)8.9 (e t)-6.6 (u)10.5 (m)-5.9 (or)-5.9 (s)8.8 ( t)4.3 (hat)-6.6 ( a)10.5 (ggr)-5.9 (es)-2 (s)-2 (i)2.6 (v)8.9 (el)2.7 (y)8.8 ( i)2.6 (n)-11.2 (v)8.9 (ade )-10.4 (s)-2 (t)-6.6 (r)-6 (uc)8.8 (t)-6.6 (ur)-6 (e)10.6 (s)-2 ( i)2.7 (n )11.3 (t)-6.6 (he ne)10.5 (c)8.9 (k)-12.9 ( o)10.6 (r)-6 ( )]TJ 0 -1.37 Td [(hav)8.9 (e pr)-6 (oduc)-2 (ed di)2.6 (s)-1.9 (t)-6.7 (an)10.5 (t)-6.6 ( )11.3 (m)4.9 (et)-6.7 (as)-2 (t)-6.6 (a)]TJ [(s)-2 (e)10.6 (s)-2 (.)4.2 ( S)2 (uc)-2 (h c)-2 (an)10.6 (c)-2 (er)-5.9 (s)8.8 ( ar)-6 (e)10.6 ( di)13.5 (f)-6.6 (f)-17.5 (i)2.6 (c)-2 (ul)2.7 (t)4.2 ( t)-6.6 (o)10.5 ( c)-2 (u)10.6 (r)-6 (e.)4.3 ( )]TJ 0 Tc 0 Tw 30.739 0 Td ( )Tj EMC /H2 <>BDC /TT1 1 Tf 0.009 Tc 0.007 Tw -30.739 -2.391 Td [(R)2.7 (ecur)-4.1 (r)6.7 (ence)10.6 ( )0.6 (o)11.3 (f)-5.8 ( )0.5 (D)13.6 (i)4.4 (f)-5.8 (f)-5.9 (e)10.7 (r)-4.2 (en)11.3 (t)-5.8 (i)4.4 (at)-5.9 (e)10.7 (d )0.6 (T)11.3 (hy)21.5 (r)-4.1 (oi)-6.5 (d)0.5 ( )0.5 (C)2.7 (a)10.7 (r)-4.2 (ci)4.4 (no)11.3 (m)-4.1 (a)]TJ 0 Tc 0 Tw 23.174 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw -23.174 -1.707 Td [(D)2.6 (ependi)2.6 (ng)-11.2 ( on)10.5 ( i)2.6 (ni)2.7 (t)-6.6 (i)2.6 (al)2.6 ( t)-6.6 (her)4.9 (apy)8.9 ( and ot)-6.6 (her)4.9 ( pr)-6 (o)10.5 (g)-11.2 (no)10.5 (s)-2 (t)-6.6 (i)2.6 (c)8.9 ( v)8.8 (ar)-6 (i)2.7 (abl)2.6 (es)-2 (,)-6.6 ( up )11.3 (t)-6.6 (o 30)10.5 (%)-4.3 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.37 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h di)13.5 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (e)10.5 (d t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.6 ( m)-6 (ay)8.8 ( hav)8.9 (e t)-6.7 (um)-6 (o)10.6 (r)-6 ( )11.3 (r)-6 (ec)-2 (u)10.5 (r)-6 (r)-5.9 (enc)-2 (es)8.8 ( )]TJ 0 -1.38 Td [(dur)-6 (i)2.7 (ng s)-2 (ev)8.9 (er)-5.9 (al)2.7 ( dec)-2 (a)]TJ -0.004 Tw [(des)8.9 (;)-6.6 ( 66%)-4.3 ( )-10.7 (o)10.6 (f)-6.7 ( t)-6.6 (hes)-2 (e r)-5.9 (ec)-2 (u)10.6 (r)-6 (r)-6 (enc)-2 (e)10.5 (s)-2 ( )-10.6 (oc)-2 (c)-2 (u)10.6 (r)-6 ( )-10.6 (w)13.5 (i)2.6 (t)-6.6 (hi)2.6 (n )-10.6 (t)-6.6 (he f)-17.5 (i)13.4 (r)-5.9 (s)8.9 (t)-6.6 ( )]TJ 0.007 Tw 0 -1.37 Td [(dec)-2 (ade a)10.5 (f)-6.6 (t)-6.6 (er)5 ( i)2.7 (ni)2.6 (t)-6.6 (i)2.6 (al)2.6 ( t)-6.6 (he)10.5 (r)-5.9 (a)10.5 (py)8.8 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 537 153.96 Tm (11)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 544.68 150 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 (l)2.6 (t)-6.6 (houg)-11.2 (h no)10.5 (t)-6.6 ( us)-2 (ual)2.6 (l)13.5 (y)8.8 ( f)-17.4 (a)10.5 (t)-6.6 (al)2.6 (,)-6.6 ( a)10.6 ( r)4.9 (ec)-2 (ur)4.9 (r)-6 (enc)-2 (e i)2.6 (n)10.5 ( )]TJ -12.935 -1.38 Td [(t)-6.6 (he nec)8.9 (k)-2 ( i)2.6 (s)-2 ( s)-2 (e)10.5 (r)-6 (i)]TJ 6.652 0 Td [(ous)-2 ( and)10.5 ( )11.3 (m)-6 (us)-2 (t)4.3 ( be )11.2 (r)-5.9 (e)10.5 (g)-11.2 (ar)-5.9 (ded)10.5 ( as)8.8 ( t)-6.6 (he)10.5 ( )11.2 (f)-17.4 (i)13.5 (r)-6 (s)-2 (t)4.3 ( s)-2 (i)13.4 (g)-11.2 (n o)10.5 (f)-6.6 ( a)10.5 ( pot)-6.6 (en)10.5 (t)-6.6 (i)2.6 (al)2.6 (l)2.7 (y)8.8 ( )]TJ -6.652 -1.37 Td [(l)2.6 (et)-6.6 (hal)2.6 ( out)-6.6 (c)-2 (o)10.5 (m)-6 (e.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 479.76 123.6 Tm [(124,)-1.8 (12)-17 (5)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 504.84 119.64 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)-6.6 (n o)10.6 (ne l)2.6 (ar)5 (g)-11.3 (e s)8.9 (t)-6.7 (udy)8.9 (,)-6.6 ( c)-2 (en)10.5 (t)-6.6 (r)-6 (al)13.5 ( n)10.6 (ec)-2 (k)-2 ( r)-5.9 (e)10.5 (c)-2 (ur)-5.9 (r)-6 (e)10.6 (nc)-2 (es)-2 ( w)13.4 (er)-6 (e )]TJ -9.326 -1.38 Td [(s)-2 (een )0.5 (m)-6 (o)10.5 (s)-2 (t)4.3 ( o)10.5 (f)-6.6 (t)-6.6 (en i)2.6 (n )11.2 (t)-6.6 (he)10.5 ( c)8.9 (er)-5.9 (v)8.8 (i)2.6 (c)-2 (al)2.6 ( l)-8.3 (y)8.9 (m)-6 (ph )0.5 (nodes)-2 ( )11.2 (\()-5.9 (74)10.6 (%)-4.3 (\))-6 (,)4.3 ( )11.2 (f)-6.6 (ol)2.6 (l)2.6 (ow)13.5 (ed b)-11.2 (y)8.9 ( t)-6.6 (he )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.37 Td [(r)-6 (em)-6 (nan)10.6 (t)-6.6 ( )11.2 (\()-5.9 (20%)6.6 (\))-6 (,)4.2 ( and )11.3 (t)-6.6 (hen)10.5 ( t)-6.6 (he)10.6 ( t)4.2 (r)-5.9 (ac)-2 (hea o)10.5 (r)-6 ( )11.3 (m)-5.9 (us)-2 (c)-2 (l)2.6 (e)10.5 ( \()-5.9 (6)10.5 (%)-4.3 (\))-6 (.)4.3 ( )11.3 (O)4.2 (f)-6.6 ( t)-6.6 (he)10.5 ( )11.3 (g)-11.3 (r)-5.9 (oup)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ 0 -1.38 Td [(l)2.6 (oc)-2 (al)2.6 ( r)-5.9 (ec)-2 (ur)4.9 (r)-6 (enc)-2 (es)8.9 (,)-6.7 ( )0.5 (8)10.5 (%)-4.3 ( ev)8.9 (ent)-6.6 (ual)2.6 (l)2.6 (y)8.9 ( d)]TJ [(i)2.6 (ed of)-6.6 ( c)-2 (anc)-2 (e)10.5 (r)-5.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 638.76 78 Tm (11)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 646.44 74.04 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(D)2.6 (i)2.6 (s)-2 (t)-6.6 (ant)4.3 ( m)-6 (e)10.5 (t)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.8 ( )]TJ -22.152 -1.37 Td [(w)13.5 (er)-5.9 (e t)-6.6 (he s)-2 (i)2.6 (t)-6.6 (es)8.8 ( o)10.6 (f)-6.6 ( )11.2 (r)-5.9 (ec)-2 (ur)4.9 (r)-6 (e)10.6 (nc)-2 (e i)2.6 (n 21%)6.6 ( o)10.5 (f)-6.6 ( pa)10.6 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( i)2.6 (n)10.5 ( t)-6.6 (hi)2.6 (s)-2 ( )11.2 (c)-2 (ohor)4.9 (t)-6.6 (,)4.3 ( m)-6 (os)8.9 (t)4.3 ( o)10.5 (f)-6.6 (t)-6.6 (en )]TJ EMC ET endstream endobj 708 0 obj 27048 endobj %% Contents for page 71 %% Original object ID: 143 0 709 0 obj << /Length 710 0 R >> stream Q q BT /Xi69 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 710 0 obj 245 endobj %% Contents for page 72 %% Original object ID: 144 0 711 0 obj << /Length 712 0 R >> stream q endstream endobj 712 0 obj 2 endobj %% Contents for page 72 %% Original object ID: 11402 0 713 0 obj << /Length 714 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 740.28 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 756.84 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 760.56 23.76 Tm (9)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(\()-6 (63%)-4.3 (\))5 ( i)2.6 (n )11.3 (t)-6.6 (he l)2.6 (un)10.6 (g)-11.2 (s)8.8 ( al)2.6 (one.)4.3 ( O)4.3 (f)-6.7 ( )11.3 (t)-6.6 (he p)]TJ [(a)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (i)2.6 (t)-6.6 (h di)2.6 (s)-2.1 (t)4.3 (ant)-6.6 ( )11.3 (m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 (,)-6.6 ( 50)10.5 (%)-4.3 ( )]TJ 0 -1.38 Td [(di)2.6 (ed o)10.5 (f)-17.5 ( c)-2 (an)10.5 (c)-2 (er)5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 95.76 502.68 Tm (11)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 103.44 498.72 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -7.522 -2.37 Td [(I)-6.6 (t)4.2 ( i)2.7 (s)-2 ( i)2.6 (m)-6 (po)10.5 (r)-6 (t)-6.6 (an)10.5 (t)-6.6 ( )11.3 (t)-6.6 (o )11.3 (r)-6 (ec)-2 (o)10.5 (g)-11.2 (ni)13.5 (z)8.9 (e t)-6.6 (hat)-6.6 ( )11.3 (t)-6.6 (he poo)10.5 (r)-5.9 ( ou)10.5 (t)-6.6 (c)-2 (o)10.5 (m)-5.9 (e)10.5 (s)-2 ( i)2.6 (n t)-6.6 (hi)2.6 (s)8.9 ( s)-2 (t)-6.6 (udy)8.9 ( w)13.4 (er)-6 (e )]TJ -0.004 Tw 0 -1.38 Td [(pr)-6 (obabl)2.6 (y)8.9 ( )-10.6 (r)-6 (el)2.6 (at)-6.6 (ed t)]TJ 0.007 Tw 7.707 0 Td [(o )11.2 (t)-6.6 (he )11.3 (m)4.9 (anner)-6 ( i)2.7 (n w)13.5 (hi)2.7 (c)-2 (h t)-6.6 (he )11.3 (r)-6 (ec)-2 (u)10.5 (r)-6 (r)4.9 (enc)-2 (e w)13.5 (as)-2 ( di)2.6 (ag)-11.3 (nos)-2 (ed)10.5 (.)-6.6 ( )11.3 (I)-6.6 (n )]TJ -7.707 -1.37 Td [(t)-6.6 (he pas)8.9 (t)-6.6 (,)4.2 ( di)2.6 (s)-2 (eas)-2 (e )11.3 (r)-5.9 (ec)-2 (u)10.5 (r)-5.9 (r)-6 (e)10.6 (nc)-2 (e w)13.5 (as)-2 ( her)-6 (al)2.6 (ded by)8.9 ( s)-2 (y)8.8 (m)-5.9 (pt)-6.6 (o)10.6 (m)-6 (s)8.9 ( or)4.9 ( pal)2.6 (pabl)2.6 (e )]TJ 0 -1.38 Td [(di)2.6 (s)-2 (eas)-2 (e on phy)8.9 (s)-2 (i)2.6 (c)-2 (al)2.6 ( ex)8.9 (am)-5.9 (i)2.6 (nat)-6.6 (i)2.6 (on,)4.3 ( r)-6 (e)10.5 (f)-17.4 (l)2.6 (ec)8.9 (t)-6.6 (i)2.6 (n)10.5 (g)-11.2 ( )11.3 (r)-6 (el)2.6 (at)-6.6 (i)2.6 (v)8.9 (el)-8.3 (y)8.9 ( l)2.6 (ar)-5.9 (g)-11.2 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 25.989 0 Td [(v)8.9 (ol)2.6 (um)-6 (e di)2.6 (s)-2 (eas)8.9 (e )]TJ 0.002 Tw -25.989 -1.37 Td [(r)-6 (ec)-2 (ur)5 (r)-6 (enc)-2 (e.)4.2 ( )]TJ 5.326 0 Td [(H)2.6 (ow)13.4 (ev)8.9 (er)]TJ 0.007 Tw 3.913 0 Td [(,)-6.6 ( t)-6.6 (o)10.5 (ol)2.6 (s)-2 ( t)-6.6 (hat)4.2 ( ar)-6 (e)10.5 ( hi)13.5 (g)-11.2 (hl)2.6 (y)8.9 ( s)-2 (ens)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (e f)-17.5 (o)10.6 (r)-6 ( de)]TJ 16.185 0 Td [(t)-6.6 (ec)8.9 (t)-6.6 (i)2.6 (ng di)2.6 (s)-2 (eas)-2 (e )]TJ -25.424 -1.38 Td [(\()-6 (e)10.6 (g)-11.3 (,)4.3 ( s)-2 (ens)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (e Tg as)-2 (s)-2 (ay)8.9 (s)-2 (,)4.3 ( hi)2.6 (g)-11.2 (h)]TJ 0 Tc 0 Tw 13.13 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(r)-6 (es)-2 (ol)2.7 (u)10.5 (t)-6.6 (i)2.6 (on nec)8.9 (k)-2 ( ul)2.6 (t)-6.6 (r)4.9 (as)-2 (ound\))-6 ( appea)10.5 (r)-6 ( )11.3 (t)-6.6 (o hav)8.9 (e )]TJ -13.467 -1.37 Td [(r)-6 (es)-2 (ul)2.7 (t)-6.6 (ed i)2.6 (n)10.5 ( ear)-6 (l)2.7 (i)2.6 (er)-6 ( de)10.5 (t)-6.6 (ec)8.8 (t)-6.6 (i)2.6 (on o)10.6 (f)-6.6 ( di)2.6 (s)-2 (eas)-2 (e )11.3 (r)-6 (ec)-2 (ur)4.9 (r)-5.9 (enc)-2 (e)10.5 (,)-6.6 ( w)13.5 (hi)2.6 (c)-2 (h i)2.6 (s)-2 ( now)13.5 ( of)-6.6 (t)-6.6 (en)10.5 ( )]TJ 0 -1.38 Td [(f)-6.6 (ound i)2.6 (n )11.2 (t)-6.6 (he )11.3 (f)-6.6 (i)2.6 (r)-6 (s)8.9 (t)-6.6 ( 2)10.5 ( t)-6.6 (o)10.5 ( 5 y)19.7 (ear)-5.9 (s)-2 ( o)10.5 (f)-6.6 ( )11.3 (f)-6.7 (ol)2.6 (l)2.6 (ow)]TJ 0 Tc 0 Tw 16.489 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td (up.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 224.64 370.2 Tm [(3,)-1.9 (1)-16.9 (26)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 242.04 366.24 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (hes)-2 (e non)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 5.065 0 Td [(pal)2.6 (pa)]TJ [(bl)2.6 (e,)4.3 ( )]TJ -0.005 Tc 0.005 Tw -25.141 -1.37 Td [(s)-5 (m)-9 (a)-3.3 (ll)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 2.663 0 Td [(v)8.9 (ol)2.6 (um)-6 (e l)2.6 (y)8.9 (m)-6 (ph nod)10.6 (e r)-6 (ec)-2 (u)10.5 (r)-5.9 (r)-6 (enc)-2 (e)10.5 (s)-2 ( o)10.6 (f)-6.7 (t)-6.6 (en)10.5 ( s)-2 (ho)10.5 (w)13.5 ( l)2.6 (i)2.6 (t)-6.6 (t)-6.6 (l)2.6 (e ev)8.8 (i)2.7 (denc)-2 (e of)-17.5 ( )]TJ -2.663 -1.38 Td [(di)2.6 (s)-2 (eas)-2 (e pr)-6 (o)10.5 (gr)-6 (es)-2 (s)-2 (i)2.6 (on ov)8.8 (er)-6 ( )11.3 (m)-6 (any)8.9 ( y)8.9 (ear)-6 (s)-2 ( and do)10.6 ( not)4.2 ( )11.3 (appear)-6 ( )11.3 (t)-6.6 (o be)10.5 ( as)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.7 (ed)10.5 ( )]TJ 0 -1.37 Td [(w)2.6 (i)2.6 (t)-6.6 (h an i)2.6 (nc)-2 (r)-5.9 (ea)10.5 (s)-2 (e i)2.6 (n )11.2 (m)-5.9 (or)4.9 (t)-6.6 (a)10.5 (l)2.7 (i)2.6 (t)-6.6 (y)8.8 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 162.24 324.72 Tm [(12)-17 (7,)-1.9 (1)-16.9 (28)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 187.44 320.76 Tm ( )Tj 0.293 0 Td ( )Tj EMC /H2 <>BDC /TT1 1 Tf 0.009 Tc -0.009 Tw -15.141 -2.391 Td [(P)2.1 (r)-4.2 (o)0.5 (gno)0.5 (s)10.6 (i)-6.5 (s)10.7 ( )]TJ 0 Tc 0 Tw 5.239 0 Td ( )Tj EMC /H3 <>BDC /TT2 1 Tf 0.016 Tc -0.005 Tw 9.96 -0 0 9.96 23.52 276.36 Tm [(A)3.1 (g)0.5 (e)5.7 (,)4.9 ( S)8.3 (ta)5.8 (g)0.5 (e)5.7 (,)4.9 ( a)5.7 (n)0.5 (d)0.5 ( )]TJ 0.01 Tc 0.001 Tw [(S)2.3 (ex at)-6.4 ( D)-3 (i)-1.1 (ag)-5.5 (n)-5.5 (o)-5.6 (si)-1.2 (s)]TJ 0 Tc 0 Tw ( )Tj 16.458 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 261.12 Tm [(A)2 (l)2.6 (t)-6.6 (houg)-11.2 (h)10.5 ( m)-5.9 (any)8.8 ( )11.3 (f)-6.6 (ac)-2 (t)-6.7 (o)10.6 (r)-6 (s)-2 ( i)2.6 (n)10.6 (f)-17.5 (l)2.6 (uenc)-2 (e)10.6 ( t)-6.7 (he)10.5 ( ou)10.5 (t)-6.6 (c)-2 (om)-5.9 (e)10.5 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )11.2 (pat)-6.6 (i)2.6 (ent)-6.7 (s)-1.9 ( w)13.5 (i)2.6 (t)-6.6 (h papi)2.6 (l)2.6 (l)2.7 (ar)-5.9 (y)8.8 ( )]TJ 0 -1.38 Td [(and )11.2 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( c)-2 (ar)5 (c)-2 (i)2.6 (nom)-6 (as)8.9 (,)-6.7 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 ( a)10.5 (g)-11.2 (e)10.5 ( at)4.2 ( )11.3 (t)-6.6 (he )11.3 (t)-6.6 (i)2.6 (m)-6 (e )11.3 (o)10.5 (f)-17.5 ( i)2.6 (ni)2.7 (t)-6.7 (i)2.7 (al)2.6 ( t)-6.6 (he)10.5 (r)-6 (apy)8.9 ( and )]TJ 0 -1.37 Td [(t)-6.6 (um)-5.9 (o)10.5 (r)-5.9 ( s)8.8 (t)-6.6 (a)10.5 (g)-11.2 (e a)10.5 (r)-6 (e i)13.5 (m)-6 (por)4.9 (t)-6.6 (a)10.5 (nt)-6.6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 152.64 234.72 Tm [(11,)-1.8 (129)]TJ 0 Tc 0 Tw 3.052 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.328 0 Td [(1)-17 (31)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 187.8 230.76 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 (g)-11.3 (e i)2.6 (s)-2 ( )11.3 (t)-6.6 (he )11.2 (m)-5.9 (o)10.5 (s)-2 (t)-6.6 ( i)2.6 (m)4.9 (por)4.9 (t)-6.6 (ant)4.3 ( pr)-6 (o)10.5 (g)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)-2 ( )]TJ -15.163 -1.38 Td [(v)8.9 (ar)-5.9 (i)2.6 (abl)2.6 (e f)-17.4 (o)10.5 (r)-6 ( )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)8.8 (er)-6 ( )11.3 (m)-5.9 (or)4.9 (t)-6.6 (al)2.6 (i)2.6 (t)-6.6 (y)8.9 (.)-6.7 ( H)2.7 (ow)13.5 (e)-11.2 (v)8.8 (er)-6 (,)-6.6 ( )11.3 (t)-6.6 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)-6 ( i)2.6 (s)8.9 ( m)-5.9 (o)10.5 (r)-6 (e )]TJ 0.002 Tw 0 -1.37 Td (aggr)Tj 0.007 Tw 2 0 Td [(es)-2 (s)-2 (i)2.6 (v)8.8 (e i)2.6 (n m)-5.9 (en)10.6 (.)-6.7 ( )11.3 (T)-10.5 (hy)8.9 (r)4.9 (oi)2.7 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( i)2.6 (s)-2 ( )11.3 (m)-6 (or)-6 (e)10.5 ( l)2.6 (et)4.2 (hal)2.6 ( i)2.6 (n pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( ol)2.7 (der)4.9 ( t)-6.6 (han)10.5 ( )]TJ -2 -1.38 Td [(40 y)8.9 (ear)-6 (s)-2 ( o)10.6 (f)-6.7 ( a)10.6 (g)-11.3 (e)10.6 (,)-6.6 ( i)2.6 (nc)-2 (r)-5.9 (ea)10.5 (s)-2 (i)2.7 (ng)-11.2 (l)2.6 (y)8.9 ( s)-2 (o w)13.5 (i)2.6 (t)-6.6 (h )0.5 (eac)-2 (h s)-2 (u)10.5 (bs)-2 (e)10.5 (q)-11.2 (uen)10.5 (t)-6.6 ( dec)-2 (ade)10.5 ( o)10.6 (f)-6.6 ( l)2.6 (i)13.4 (f)-17.4 (e.)4.3 ( )11.2 (T)-10.5 (he)10.6 ( )]TJ 0 -1.37 Td [(m)-6 (or)4.9 (t)-6.6 (al)2.6 (i)2.6 (t)-6.6 (y)8.8 ( r)-5.9 (at)-6.6 (e)10.6 ( i)2.6 (nc)-2 (r)-5.9 (eas)-2 (es)8.9 ( )11.3 (dr)-6 (am)-5.9 (a)10.5 (t)-6.6 (i)2.6 (c)-2 (al)2.6 (l)2.7 (y)8.8 ( af)-6.6 (t)-6.6 (er)4.9 ( a)10.5 (g)-11.2 (e 60)10.6 ( y)8.9 (ear)-5.9 (s)-2 (.)-6.6 ( H)2.7 (ow)13.5 (ev)8.8 (er)-6 (,)-6.6 ( t)-6.6 (u)10.5 (m)-5.9 (or)4.9 ( )]TJ 0 -1.38 Td [(r)-6 (ec)-2 (ur)5 (r)-6 (enc)-2 (e )11.2 (s)-1.9 (how)13.5 (s)-2 ( a r)-6 (e)10.5 (m)5 (ar)4.9 (k)-12.8 (abl)2.6 (y)8.8 ( di)2.6 (f)-6.6 (f)-6.6 (er)-5.9 (en)]TJ 17.5 0 Td [(t)-6.6 ( behav)8.9 (i)2.6 (or)-5.9 ( w)13.5 (i)2.6 (t)-6.6 (h r)-5.9 (es)-2 (pec)8.9 (t)-6.6 ( )11.2 (t)-6.6 (o )11.3 (a)10.5 (g)-11.2 (e.)4.3 ( )]TJ -17.5 -1.37 Td [(R)2.6 (ec)-2 (ur)-5.9 (r)-6 (enc)-2 (e)10.5 ( )11.3 (f)-6.6 (r)-6 (e)10.6 (q)-11.2 (uenc)-2 (i)2.6 (es)-2 ( )11.2 (ar)-6 (e hi)13.5 (g)-11.2 (hes)-2 (t)4.3 ( \()-6 (40)10.5 (%)-4.3 (\))4.9 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )11.2 (t)-6.6 (ho)10.5 (s)-2 (e y)8.9 (oung)-11.2 (er)4.9 ( t)-6.6 (h)10.5 (an 20)10.5 ( )]TJ 0 -1.38 Td [(y)8.9 (ear)-6 (s)-2 ( or)-6 ( ol)2.6 (de)10.6 (r)-6 ( )11.3 (t)-6.6 (han 60)10.5 ( y)8.9 (ear)-6 (s)-2 (;)4.3 ( r)-6 (ec)-2 (u)10.5 (r)-6 (r)-5.9 (en)10.6 (c)-2 (e a)10.5 (t)-6.6 ( o)10.5 (t)-6.6 (her)5 ( )11.2 (ag)-11.2 (es)8.9 ( ens)-2 (ues)8.9 ( i)2.6 (n onl)2.6 (y)8.9 ( )]TJ 0 -1.37 Td [(about)-6.6 ( 20)10.5 (%)-4.3 ( o)10.5 (f)-6.6 ( pa)10.6 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 133.08 113.28 Tm [(11,)-1.8 (129)]TJ 0 Tc 0 Tw 3.052 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.328 0 Td [(1)-17 (32)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 168.24 109.32 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (hi)2.6 (s)-2 ( di)2.7 (s)-2 (par)-6 (i)]TJ 5.109 0 Td [(t)-6.6 (y)8.9 ( be)10.5 (t)-6.6 (w)2.6 (een c)-2 (anc)-2 (er)]TJ 0 Tc 0 Tw 8.087 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(r)-6 (el)2.6 (a)10.5 (t)-6.6 (ed )]TJ 0.007 Tw -26.924 -1.38 Td [(m)-6 (or)4.9 (t)-6.6 (al)2.6 (i)2.6 (t)-6.6 (y)8.8 ( and t)-6.6 (he)10.6 ( )11.2 (f)-6.6 (r)-5.9 (e)10.5 (q)-11.2 (uen)10.5 (c)-2 (y)8.9 ( of)-6.6 ( t)-6.6 (u)10.5 (m)-5.9 (o)10.5 (r)-6 ( )11.3 (r)-6 (ec)-2 (ur)4.9 (r)-6 (enc)-2 (e p)10.5 (r)-6 (obabl)2.6 (y)8.8 ( ac)-2 (c)-2 (ount)-6.6 (s)-2 ( )11.3 (f)-6.6 (or)4.9 ( )]TJ 0 -1.37 Td [(m)-6 (os)-2 (t)4.3 ( o)10.5 (f)-6.6 ( t)-6.6 (h)10.5 (e di)2.6 (s)-2 (a)10.5 (g)-11.2 (r)-6 (ee)10.5 (m)-5.9 (en)10.6 (t)-6.7 (s)-2 ( a)10.6 (m)-6 (on)10.5 (g)-11.2 ( )11.2 (c)-2 (l)2.6 (i)2.7 (ni)2.6 (c)-2 (i)2.6 (ans)-2 ( c)-2 (onc)-2 (er)-6 (ni)2.6 (ng opt)-6.6 (i)13.5 (m)-6 (al)2.6 ( t)4.2 (r)-5.9 (eat)4.3 (m)-6 (ent)4.3 ( )]TJ 0 -1.38 Td [(f)-6.6 (or)4.9 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)-6.6 (i)13.5 (at)-6.6 (ed )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.7 (no)10.5 (m)-5.9 (a.)4.3 ( )11.3 (H)2.6 (ow)13.5 ( c)-2 (l)2.6 (i)2.6 (n)-11.2 (i)2.6 (c)-2 (i)2.6 (ans)-2 ( as)-2 (s)-2 (es)-2 (s)-2 ( )]TJ 0 -1.37 Td [(t)-6.6 (he i)2.6 (m)-6 (po)10.5 (r)-5.9 (t)-6.6 (an)10.6 (c)-2.1 (e)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc -0.004 Tw 6.88 0 Td [(o)10.5 (f)-6.6 ( t)-6.6 (um)-5.9 (o)10.5 (r)-6 ( r)-5.9 (ec)-2 (ur)5 (r)-6 (enc)-2 (e \()-5.9 (as)8.9 ( )-10.6 (oppos)-2 (ed t)4.3 (o )-10.6 (c)-2 (anc)-2 (er)]TJ 0 Tc 0 Tw 18.826 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(s)-2 (pec)-2 (i)13.5 (f)-17.5 (i)2.6 (c)8.9 ( )]TJ 0.007 Tw 8.511 42.152 Td [(s)-2 (ur)-6 (v)8.9 (i)2.6 (v)8.9 (a)-11.3 (l)2.7 (\))-6 ( ac)-1.9 (c)-2.1 (ount)-6.6 (s)8.9 ( )11.2 (f)-17.5 (o)10.6 (r)-6 ( )11.3 (m)-6 (u)10.6 (c)-2 (h o)10.5 (f)-6.6 ( t)-6.6 (he)10.5 ( debat)-6.6 (e)10.5 ( s)-2 (u)10.5 (r)-5.9 (r)-6 (oun)10.5 (di)2.6 (ng)-11.3 ( )11.3 (t)-6.6 (he i)2.6 (n)10.5 (f)-17.4 (l)2.6 (uenc)-2 (e)10.6 ( o)10.5 (f)-6.6 ( a)10.5 (g)-11.2 (e)10.5 ( )]TJ 0 -1.38 Td [(on t)-6.6 (he)10.6 ( t)4.2 (r)-5.9 (eat)4.2 (m)-5.9 (ent)4.3 ( pl)2.6 (an )11.3 (f)-6.6 (or)5 ( c)-2 (hi)2.6 (l)2.6 (dr)-6 (en and)10.5 ( )0.5 (y)8.8 (oung)-11.3 ( )0.5 (adul)13.5 (t)-6.6 (s)-2 (.)4.2 ( )]TJ 0 Tc 0 Tw 23.043 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -23.043 -2.37 Td [(C)2.6 (hi)2.6 (l)2.6 (dr)-5.9 (en t)-6.6 (y)8.9 (pi)2.6 (c)-2 (al)2.6 (l)-8.3 (y)8.9 ( pr)-5.9 (es)-2 (ent)-6.7 ( w)13.5 (i)2.6 (t)-6.6 (h m)-6 (o)10.5 (r)-5.9 (e adv)8.9 (anc)-2 (ed di)2.6 (s)8.8 (eas)-2 (e and hav)8.8 (e )11.3 (m)-6 (or)-6 (e)10.5 ( )]TJ 0.004 Tc -0.01 Tw 0 -1.38 Td [(t)-0.6 (u)5.7 (mo)16.5 (r r)]TJ -0.002 Tc 0.007 Tw [(ec)-2 (ur)5 (r)-6 (enc)-2 (es)8.9 ( a)10.5 (f)-6.6 (t)-6.7 (er)4.9 ( t)4.3 (her)-6 (apy)8.9 ( t)-6.6 (han adul)13.5 (t)-6.6 (s)-2 (,)4.2 ( y)8.9 (et)-6.7 ( )11.3 (t)4.3 (hei)2.6 (r)-6 ( pr)-6 (o)10.6 (g)-11.3 (nos)-2 (i)2.6 (s)8.8 ( )11.3 (f)-17.5 (o)10.6 (r)-6 ( s)-2 (u)10.5 (r)-5.9 (v)8.8 (i)2.6 (v)-2 (al)2.6 ( )]TJ 0 -1.37 Td [(i)2.6 (s)-2 ( g)-11.2 (ood)10.5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 443.64 446.16 Tm [(133,)-1.8 (1)-17 (34)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 468.72 442.2 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 (l)2.6 (t)-6.6 (houg)-11.2 (h )11.2 (t)-6.6 (h)10.5 (e pr)-5.9 (o)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)8.9 ( o)10.5 (f)-6.6 ( c)-2 (hi)2.6 (l)2.6 (dr)-5.9 (en w)13.4 (i)2.7 (t)-6.7 (h t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (a)10.5 (r)-6 (c)-2 (i)2.6 (nom)-6 (a)10.5 ( i)2.6 (s)-2 ( )]TJ -0.004 Tw -6.054 -1.38 Td [(f)-6.6 (av)8.9 (or)-6 (abl)2.6 (e f)-17.4 (or)4.9 ( )-10.6 (l)2.6 (on)10.5 (g)]TJ 0 Tc 0 Tw 7.707 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(t)-6.6 (er)4.9 (m)-6 ( s)8.9 (ur)-5.9 (v)8.8 (i)-8.2 (v)8.8 (al)2.6 ( \()-5.9 (90%)-4.3 ( a)10.6 (t)-6.6 ( 20)10.5 ( y)8.9 (ear)-5.9 (s)-2 (\))4.9 (,)-6.6 ( )11.2 (t)-6.6 (he s)8.9 (t)-6.6 (andar)-5.9 (di)2.6 (z)8.9 (ed )]TJ -0.005 Tc 0.01 Tw -8.033 -1.37 Td [(m)-9 (o)-3.3 (r)1.9 (t)-9.6 (a)-3.4 (lit)-9.6 (y)5.9 ( r)-9 (a)-3.3 (t)-9.7 (io)-3.3 ( is)5.8 ( 8)]TJ 0 Tc 0 Tw 7.815 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(f)-6.6 (ol)2.7 (d hi)13.4 (g)-11.2 (he)10.5 (r)-6 ( )11.3 (t)-6.6 (han p)10.6 (r)-6 (edi)2.6 (c)-2 (t)-6.6 (ed)10.5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 622.08 415.8 Tm (135)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 633.6 411.84 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(S)2 (om)-5.9 (e c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (i)2.6 (ans)-2 ( bel)2.6 (i)2.6 (ev)8.8 (e )]TJ -20.989 -1.38 Td [(t)-6.6 (hat)4.3 ( y)8.8 (oung)-11.2 ( a)10.5 (g)-11.2 (e)10.5 ( i)2.6 (m)-6 (pa)10.5 (r)-5.9 (t)-6.6 (s)8.8 ( s)8.9 (uc)-2.1 (h a )11.2 (f)-6.6 (av)8.8 (or)-6 (abl)2.6 (e i)2.6 (n)10.5 (f)-17.5 (l)2.7 (uenc)-2 (e)10.6 ( on )0.5 (s)-2.1 (u)10.6 (r)-6 (v)8.9 (i)2.6 (v)8.9 (a)-11.3 (l)2.7 ( t)-6.7 (hat)-6.7 ( )0.5 (i)13.4 (t)-6.6 ( )]TJ 0 -1.37 Td [(ov)8.8 (er)-6 (s)-2 (hadow)13.5 (s)-2 ( t)-6.6 (he behav)8.9 (i)-8.3 (or)-6 ( ex)8.9 (pec)-2 (t)-6.5 (ed )11.2 (f)-6.6 (r)-5.9 (o)10.5 (m)4.9 ( t)-6.6 (he)10.6 ( c)-2 (ha)10.5 (r)-5.9 (ac)-2 (t)-6.6 (e)10.6 (r)-6 (i)2.6 (s)-2 (t)-6.6 (i)2.6 (c)-2 (s)-2 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (he)10.6 ( t)-6.6 (u)10.6 (m)-6 (or)4.9 (.)-6.6 ( )]TJ 0 -1.38 Td [(T)-10.6 (he)10.5 (r)-5.9 (e)10.5 (f)-17.5 (o)10.5 (r)-5.9 (e,)4.3 ( t)-6.6 (hey)8.9 ( c)-2 (l)2.6 (as)-2 (s)-2 (i)13.5 (f)-17.5 (y)8.9 ( )11.2 (m)-5.9 (os)-2.1 (t)4.3 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )11.3 (t)-6.7 (um)-6 (o)10.6 (r)-6 (s)8.9 ( as)-2 ( l)13.5 (ow)]TJ 0 Tc 0 Tw 22.413 0 Td (-)Tj 0.004 Tc -0.01 Tw 0.337 0 Td [(ri)8.6 (s)4 (k)-6.8 ( t)-0.6 (u)5.7 (mo)16.5 (rs)14.9 ( )-10.7 (t)-0.6 (h)5.7 (a)16.5 (t)-0.6 ( ma)5.6 (y)14.9 ( )]TJ -0.002 Tc 0.007 Tw -22.75 -1.37 Td [(be t)4.3 (r)-6 (eat)-6.6 (ed)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 6.815 0 Td [(l)2.6 (obec)-2 (t)-6.6 (om)4.9 (y)8.9 ( al)2.6 (one.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 563.4 355.08 Tm (136)Tj 0 Tc 0 Tw 1.672 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.328 0 Td [(1)-17 (38)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 588.96 351.12 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(H)2.6 (o)-11.2 (w)13.5 (e)-11.2 (v)8.8 (er)-6 (,)-6.6 ( )11.3 (m)-6 (os)-2 (t)4.2 ( phy)8.9 (s)-2 (i)2.6 (c)-2 (i)2.6 (ans)-2 ( t)-6.6 (r)-5.9 (ea)10.5 (t)-6.6 (i)2.7 (n)10.5 (g)-11.2 ( )]TJ -16.946 -1.38 Td [(t)-6.6 (he di)2.7 (s)-2 (eas)-2 (e)10.5 ( bel)2.6 (i)2.6 (ev)8.8 (e t)-6.6 (hat)-6.6 ( )11.2 (t)4.3 (um)-5.9 (or)4.9 ( s)-2 (t)-6.6 (a)10.5 (g)-11.2 (e)10.5 ( and)10.5 ( i)2.6 (t)-6.6 (s)-2 ( hi)2.6 (s)8.8 (t)-6.6 (ol)2.6 (og)-11.2 (i)2.7 (c)-2 ( )11.2 (f)-6.6 (eat)-6.6 (u)10.5 (r)-5.9 (es)8.9 ( s)-2 (houl)2.6 (d be)10.5 ( )]TJ 0 -1.37 Td [(as)-2 ( s)-2 (i)13.4 (g)-11.2 (ni)13.4 (f)-17.4 (i)2.6 (c)-2 (ant)4.2 ( as)-2 ( )11.3 (t)-6.7 (he pa)10.5 (t)-6.6 (i)13.5 (ent)-6.6 <92>2.6 (s)-2 ( a)10.5 (g)-11.2 (e i)2.6 (n)10.5 ( det)-6.6 (e)10.5 (r)-5.9 (m)-6 (i)2.6 (ni)2.6 (n)10.5 (g)-11.2 ( )11.3 (m)-6 (ana)10.5 (g)-11.2 (em)-6 (en)10.5 (t)-6.6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 709.68 324.72 Tm [(11,)-1.8 (133,)-19.1 (13)-17 (9,)-1.8 (1)-17 (40)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 758.04 320.76 Tm ( )Tj -0.002 Tc 0.007 Tw -31.978 -1.38 Td [(P)2 (r)-6 (og)-11.3 (no)10.5 (s)-2 (i)2.6 (s)-2 ( i)2.6 (s)-2 ( l)2.6 (es)-2 (s)8.9 ( )11.2 (f)-17.5 (av)8.9 (or)-5.9 (ab)10.6 (l)2.6 (e i)2.6 (n m)-6 (en)]TJ 0 Tc 0 Tw 15.12 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(t)-6.6 (han)10.5 ( i)2.6 (n w)13.5 (om)-6 (en,)4.3 ( but)4.3 ( t)-6.6 (he)10.5 ( di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (enc)-2 (e)10.5 ( i)2.6 (s)-2 ( )]TJ -0.005 Tc 0.01 Tw -15.402 -1.37 Td [(u)-3.3 (s)-5.1 (u)-3.3 (a)-3.4 (lly)5.9 ( s)-5 (m)-9 (a)-3.3 (ll.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 471 294.36 Tm [(11,)-19 (13)-16.9 (8)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 492.36 290.4 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(O)-6.6 (ne s)8.9 (t)-6.6 (udy)8.8 ( )11.3 (f)-17.5 (ound )11.3 (t)-6.6 (hat)4.3 ( )11.2 (g)-11.2 (ende)10.5 (r)-6 ( w)13.5 (as)-2 ( an i)2.6 (ndependen)10.5 (t)-6.6 ( )]TJ -8.196 -1.38 Td [(pr)-6 (o)10.5 (g)-11.2 (nos)-2 (t)-6.6 (i)2.6 (c)8.9 ( v)8.9 (ar)-5.9 (i)2.6 (abl)2.6 (e )11.3 (f)-17.5 (or)4.9 ( s)8.8 (ur)-6 (v)8.9 (i)-8.2 (v)8.8 (al)2.6 ( and t)-6.7 (hat)4.3 ( t)-6.6 (he)10.6 ( r)-6 (i)]TJ 19.837 0 Td [(s)8.9 (k)-2 ( o)10.5 (f)-6.6 ( dea)10.5 (t)-6.6 (h )11.3 (f)-6.6 (r)-5.9 (o)10.5 (m)-6 ( )11.3 (c)-2 (anc)-2 (er)5 ( w)13.4 (as)-2 ( )]TJ -19.837 -1.37 Td [(about)-6.6 ( )11.3 (t)-6.6 (w)13.4 (i)2.7 (c)-2 (e as)-2 ( hi)2.6 (g)-11.2 (h)10.5 ( i)2.6 (n )11.2 (m)5 (en as)-2 ( i)2.6 (n w)13.5 (om)-5.9 (en.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 603.24 264 Tm (11)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 610.92 260.04 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(B)2 (ec)-2 (au)10.5 (s)-2 (e o)10.6 (f)-6.6 ( t)-6.7 (hi)2.6 (s)8.9 ( r)-6 (i)2.6 (s)8.9 (k)-2 ( )11.3 (f)-17.5 (ac)8.9 (t)-6.6 (or)4.9 (,)-6.6 ( )11.2 (m)-5.9 (en)10.6 ( )]TJ -18.935 -1.37 Td [(w)2.6 (i)2.6 (t)-6.6 (h t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a)]TJ 0 Tc 0 Tw <97>Tj -0.002 Tc 0.007 Tw 10.913 0 Td [(es)-2 (pec)-2 (i)2.6 (al)2.6 (l)-8.2 (y)8.8 ( t)-6.6 (hos)-2 (e w)13.5 (ho)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 9.478 0 Td [(ar)-6 (e)10.5 ( ol)2.6 (der)-6 ( )11.3 (t)-6.6 (han 40)10.5 ( y)8.9 (ear)-6 (s)]TJ 0 Tc 0 Tw 10.25 0 Td <97>Tj -0.002 Tc 0.007 Tw -30.641 -1.38 Td [(m)-6 (ay)8.9 ( be r)-6 (e)10.5 (g)-11.2 (a)10.5 (r)-5.9 (ded w)13.5 (i)2.6 (t)-6.6 (h s)-2 (p)10.5 (ec)-2.1 (i)2.7 (al)2.6 ( c)-2 (onc)-2 (er)-6 (n)]TJ 0 Tc 0 Tw (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 593.52 233.64 Tm (141)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 605.04 229.68 Tm ( )Tj 0.272 0 Td ( )Tj EMC /H3 <>BDC /TT2 1 Tf 0.01 Tc 0.001 Tw 9.96 -0 0 9.96 405 204.36 Tm [(F)-5.5 (am)-4.6 (i)-1.2 (l)-1.1 (i)-1.2 (al)-1.1 ( S)2.3 (yn)-5.5 (d)-5.5 (r)1.4 (o)-5.5 (m)-4.6 (es )]TJ 0 Tc 0 Tw ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 189 Tm [(Fam)-6 (i)2.6 (l)2.6 (i)2.6 (al)2.6 (,)-6.6 ( non)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 5.989 0 Td [(m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( c)8.9 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a )11.2 (ac)-2 (c)-2 (ount)4.2 (s)-2 ( )11.3 (f)-6.6 (or)4.9 ( a)10.6 (bout)-6.6 ( 5)10.5 (%)-4.3 ( o)10.5 (f)-6.6 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( )]TJ -5.989 -1.37 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (as)-1.9 ( )11.2 (\()-5.9 (P)12.8 (T)-10.6 (C)2.6 (s)-2 (\))-5.9 ( and)10.5 (,)-6.6 ( i)2.6 (n )11.2 (s)-2 (om)-6 (e)10.6 ( c)-2.1 (as)-2 (es)8.8 (,)-6.6 ( )11.3 (m)4.9 (ay)8.8 ( be c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 (l)-8.3 (y)8.9 ( m)-6 (or)-6 (e )]TJ -0.004 Tw 0 -1.38 Td [(aggr)-6 (es)-2 (s)-2 (i)2.6 (v)8.8 (e )-10.6 (t)-6.6 (han t)-6.6 (he s)-2 (por)4.9 (adi)2.6 (c)-2 ( f)-17.5 (or)5 (m)4.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 573.84 162.6 Tm [(142,)-1.8 (1)-17 (43)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 598.92 158.64 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(For)-6 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( )11.3 (t)-6.6 (o be)10.5 ( c)-2 (ons)-2 (i)2.6 (der)-6 (ed)10.5 ( as)8.9 ( )]TJ -17.848 -1.37 Td [(hav)8.9 (i)2.6 (ng)-11.2 ( )11.3 (f)-17.5 (a)10.5 (m)-5.9 (i)2.6 (l)2.6 (i)2.6 (al)2.6 ( papi)2.6 (l)2.6 (l)2.7 (ar)-16.8 (y)8.9 ( c)-2 (ar)-6 (c)-2 (i)2.7 (nom)-6 (a,)4.2 ( )11.3 (m)-6 (os)-2 (t)4.2 ( )0.5 (s)8.8 (t)-6.6 (udi)2.6 (es)-2 ( r)4.9 (eq)-11.2 (ui)2.6 (r)-6 (e)10.6 ( at)4.3 ( l)2.6 (eas)-2 (t)4.2 ( )0.5 (3 )]TJ -0.016 Tc 0.016 Tw 0 -1.38 Td [(f)-31.5 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For personal use only. Not approved for distribution. 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Tw 0.283 0 Td [(I)-6.6 (n pat)-6.6 (i)2.7 (e)10.5 (nt)-6.6 (s)]TJ 0 Tc 0 Tw 4.609 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(w)13.5 (i)2.6 (t)-6.6 (h s)-2 (por)-5.9 (adi)2.6 (c)8.9 ( m)-6 (edul)2.6 (l)13.5 (ar)-6 (y)8.9 ( c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (,)-6.6 ( a)10.5 ( s)-2 (o)10.5 (m)-5.9 (at)-6.6 (i)2.6 (c)8.9 ( )]TJ ET /CS0 cs 0 0.357 0.6 scn 23.52 289.08 62.88 0.84 re f BT /CS1 cs 0 scn -0.005 Tc 0.005 Tw 11.04 -0 0 11.04 23.52 275.88 Tm [(RE)-1 (T)]TJ 0 Tc 0 Tw 2 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(onc)-2 (o)10.5 (g)-11.2 (ene)10.6 ( )11.2 (m)-5.9 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (on )11.3 (c)-2 (on)10.6 (f)-17.5 (er)-6 (s)8.9 ( an adv)8.8 (er)-6 (s)-2 (e)10.6 ( pr)-5.9 (o)10.5 (gnos)-2 (i)2.6 (s)-2.1 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 292.68 279.84 Tm (156)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 304.2 275.88 Tm ( )Tj 0.283 0 Td ( )Tj ET EMC BT /H4 <>BDC /TT3 1 Tf 0.006 Tc -0.006 Tw 11.04 -0 0 11.04 23.52 248.64 Tm [(His)-4.9 (t)-9.5 (o)-3.2 (lo)-3.2 (g)-3.2 (y)6 ( )]TJ 0 Tc 0 Tw 4.467 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw -4.467 -1.413 Td [(A)2 (l)2.6 (t)-6.6 (houg)-11.2 (h)10.5 ( s)-2 (ur)-6 (v)8.9 (i)2.6 (v)8.9 (al)2.6 ( r)-5.9 (at)-6.6 (es)-2 ( w)13.4 (i)2.7 (t)-6.7 (h t)-6.6 (y)8.9 (pi)2.6 (c)-2 (al)2.6 ( papi)2.7 (l)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( c)-2 (ar)-6 (c)-2 (i)2.7 (nom)-6 (a a)10.5 (r)-6 (e )11.2 (q)-11.2 (ui)2.6 (t)-6.6 (e)10.5 ( )11.3 (g)-11.3 (ood)10.5 (,)-6.6 ( )]TJ 0.002 Tw 0 -1.37 Td [(c)-2 (anc)-2 (er)]TJ 0 Tc 0 Tw 3 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(s)-2 (p)10.5 (ec)-2 (i)13.5 (f)-17.5 (i)2.6 (c)-2 ( )11.3 (m)-6 (or)4.9 (t)-6.6 (al)2.6 (i)2.6 (t)-6.6 (y)8.9 ( r)-6 (at)-6.6 (es)8.9 ( v)8.9 (ar)-5.9 (y)8.8 ( c)-2 (ons)-2 (i)2.6 (der)-6 (abl)2.6 (y)8.9 ( w)2.6 (i)2.6 (t)-6.6 (h c)-2 (er)4.9 (t)-6.6 (ai)2.6 (n hi)2.6 (s)-2 (t)-6.6 (ol)2.6 (o)10.6 (g)-11.2 (i)2.6 (c)-2 ( )]TJ -3.337 -1.38 Td [(s)-2 (ubs)-2 (et)-6.6 (s)8.8 ( o)10.5 (f)-6.6 ( t)-6.6 (u)10.6 (m)-6 (or)5 (s)-2 (.)]TJ 0 Tc 0 Tw 6.96 -0 0 6.96 113.52 206.64 Tm (1)Tj 11.04 -0 0 11.04 117.36 202.68 Tm ( )Tj -0.016 Tc 0.021 Tw 0.283 0 Td [(A)-1.2 ( we)-25.2 (l)-11.4 (l)]TJ 0 Tc 0 Tw 2.641 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(def)-17.5 (i)2.6 (ned)10.6 ( t)-6.7 (u)10.6 (m)-6 (or)4.9 ( c)-2 (aps)-2 (ul)2.7 (e,)4.3 ( w)13.4 (hi)2.6 (c)-2 (h i)2.6 (s)-2 ( )11.2 (f)-17.4 (ound i)2.6 (n abou)10.5 (t)-6.6 ( )]TJ -11.761 -1.37 Td [(10%)-4.3 ( o)10.5 (f)-6.6 ( P)12.8 (T)-10.5 (C)2.6 (s)-2 (,)4.2 ( i)2.7 (s)-2 ( a)10.5 ( par)4.9 (t)-6.6 (i)2.6 (c)8.9 (ul)2.6 (ar)-6 (l)2.6 (y)8.9 ( f)-17.5 (av)8.9 (or)-6 (abl)2.7 (e pr)-6 (o)10.5 (g)-11.2 (no)10.5 (s)-2 (t)4.3 (i)2.6 (c)-2 ( i)2.6 (ndi)2.6 (c)-2 (at)-6.6 (or)-6 (.)4.3 ( A)1.9 ( )0.5 (w)13.4 (or)-6 (s)-2 (e )]TJ 0 -1.38 Td [(pr)-6 (o)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)-2 ( i)2.6 (s)-2 ( a)10.6 (s)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (ed)10.5 ( )11.3 (w)2.6 (i)2.6 (t)-6.6 (h:)-6.6 ( 1)10.5 (\))-6 ( anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)8.9 ( t)-6.6 (u)10.5 (m)-6 (or)4.9 ( )]TJ -0.004 Tw 21.707 0 Td [(t)-6.6 (r)-6 (ans)8.9 (f)-6.6 (or)4.9 (m)-6 (at)-6.6 (i)2.6 (on)10.5 (;)-6.6 ( )-10.6 (2)10.6 (\))-6 ( t)-6.6 (al)2.6 (l)]TJ 0 Tc 0 Tw 9.359 0 Td (-)Tj -0.005 Tc 0.005 Tw 0.337 0 Td [(c)-5 (e)-3.4 (ll )]TJ -0.002 Tc 0.007 Tw -31.402 -1.37 Td [(papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( )-10.5 (v)8.9 (ar)-6 (i)2.7 (ant)-6.6 (s)-2 (,)-6.6 ( w)13.5 (hi)2.6 (c)-2 (h hav)8.8 (e a 10)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 15.576 0 Td [(y)8.9 (ear)-6 ( )11.3 (m)-6 (or)4.9 (t)-6.6 (al)2.7 (i)2.6 (t)-6.6 (y)8.8 ( o)10.6 (f)-17.5 ( up)10.5 ( t)-6.6 (o)10.6 ( 25%)6.5 (;)-6.6 ( 3)10.5 (\))-5.9 ( )]TJ -15.576 -1.38 Td [(c)-2 (ol)2.6 (um)-5.9 (nar)-6 ( v)8.9 (ar)-5.9 (i)2.6 (ant)4.2 ( )0.5 (papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a )11.3 (\()-6 (a )11.3 (r)-6 (api)2.6 (dl)2.6 (y)8.8 ( g)-11.2 (r)4.9 (ow)2.6 (i)2.6 (ng)-11.3 ( )11.3 (t)-6.6 (um)-6 (o)10.5 (r)-5.9 ( w)13.4 (i)2.7 (t)-6.7 (h a hi)13.5 (g)-11.2 (h )]TJ 0 -1.37 Td [(m)-6 (or)4.9 (t)-6.6 (al)2.6 (i)2.6 (t)-6.6 (y)8.8 ( r)-5.9 (at)-6.6 (e)10.6 (\))-6 (;)4.2 ( )0.5 (and 4)10.5 (\))-5.9 ( di)13.5 (f)-6.6 (f)4.3 (us)-2 (e s)-2 (c)-2 (l)2.6 (er)-5.9 (os)-2 (i)2.6 (n)10.5 (g v)8.9 (ar)-5.9 (i)2.6 (ant)-6.6 (s)-2 (,)4.2 ( )11.3 (w)13.5 (h)-11.2 (i)2.6 (c)-2 (h i)2.6 (nf)-17.5 (i)2.6 (l)2.6 (t)4.3 (r)-6 (at)-6.6 (e)10.5 ( t)-6.6 (he)10.5 ( ent)-6.6 (i)2.6 (r)-6 (e)10.6 ( )]TJ -0.005 Tc 0.005 Tw 0 -1.38 Td [(g)-14.2 (la)-3.4 (n)]TJ -0.002 Tc 0.002 Tw 1.891 0 Td (d.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 53.64 115.56 Tm [(34,)-1.8 (157,)-19.1 (15)-17 (8)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 88.44 111.6 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -6.163 -2.37 Td [(N)2.6 (I)-6.6 (FT)-10.6 (P)12.9 (,)-6.6 ( )11.2 (f)-6.6 (or)4.9 (m)-6 (er)-6 (l)2.7 (y)8.8 ( )11.3 (k)-12.9 (now)13.5 (n as)-2 ( noni)2.6 (nv)8.9 (as)-2 (i)2.6 (v)8.9 (e enc)-2 (aps)-2 (ul)2.6 (a)-11.3 (t)-6.6 (ed )]TJ 0 Tc 0 Tw 23.543 0 Td (f)Tj -0.005 Tc 0.005 Tw 0.283 0 Td [(o)-3.3 (llic)-4.9 (u)-3.4 (la)-3.4 (r)]TJ 0 Tc 0 Tw 3.37 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(v)8.9 (ar)-5.9 (i)2.6 (ant)-6.6 ( o)10.5 (f)-6.6 ( )]TJ -27.478 -1.37 Td [(papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-6 (a )11.2 (\()]TJ 0 Tc 0 Tw 12.467 0 Td (E)Tj -0.005 Tc 0.01 Tw 0.663 0 Td [(F)-2.7 (V)-1 (P)-1.1 (T)-13.6 (C\))1.9 (,)1.3 ( is)-5 ( )]TJ -0.002 Tc 0.007 Tw [(c)-2 (ha)10.5 (r)-5.9 (ac)-2 (t)4.3 (er)-6 (i)2.6 (z)8.9 (ed by)8.9 ( i)2.6 (t)-6.6 (s)-2 ( )11.3 (f)-17.5 (ol)2.6 (l)2.7 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( )]TJ -13.13 -1.38 Td [(g)-11.2 (r)4.9 (ow)13.5 (t)-6.6 (h pat)-6.6 (t)-6.6 (e)10.5 (r)-6 (n,)4.2 ( enc)]TJ 8.543 0 Td [(aps)-2 (ul)13.5 (at)-6.6 (i)2.6 (on or)5 ( c)-2.1 (l)2.7 (ear)4.9 ( dem)-6 (a)10.6 (r)-6 (c)-2 (at)-6.7 (i)2.7 (o)10.5 (n o)10.6 (f)-6.7 ( )0.5 (t)-6.7 (he)10.5 ( t)-6.6 (u)10.5 (m)-5.9 (or)4.9 ( )11.3 (f)-6.6 (r)-6 (o)10.6 (m)-6 ( )]TJ -8.543 -1.37 Td [(adj)-8.3 (ac)-2 (ent)4.3 ( t)-6.6 (i)2.6 (s)-2 (s)-2 (ue)]TJ 0 Tc 0 Tw 6.652 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(w)13.5 (i)2.6 (t)-6.6 (h no i)13.5 (nv)8.8 (as)-2 (i)2.6 (on)]TJ [(,)-6.6 ( and nuc)-2 (l)2.6 (ear)4.9 ( )11.2 (f)-17.4 (ea)10.6 (t)-6.7 (ur)-5.9 (es)8.9 ( o)10.5 (f)-6.6 ( papi)2.6 (l)2.7 (l)2.6 (ar)-5.9 (y)8.8 ( )]TJ 0.002 Tw 27.62 42.935 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 458.88 517.92 Tm [(159,)-1.8 (1)-17 (60)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 483.96 513.96 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(N)2.6 (I)-6.6 (FT)-10.6 (P)2 ( )11.3 (t)4.2 (um)-6 (or)-6 (s)8.9 ( hav)8.9 (e a l)2.6 (ow)13.5 ( r)-6 (i)2.7 (s)8.8 (k)-12.8 ( )11.2 (f)-6.6 (or)4.9 ( adv)8.9 (er)-5.9 (s)-2 (e out)4.3 (c)-2 (om)-5.9 (es)8.9 ( and)10.5 (,)-6.6 ( )]TJ -7.435 -1.38 Td [(t)-6.6 (her)-6 (e)10.6 (f)-6.6 (or)-5.9 (e)10.5 (,)-6.6 ( )11.2 (r)-5.9 (e)10.5 (q)-11.2 (ui)2.7 (r)-6 (e l)2.7 (es)-2 (s)8.9 ( a)10.5 (gg)-11.3 (r)5 (es)-2 (s)-2 (i)2.6 (v)8.9 (e t)-6.6 (r)-5.9 (ea)10.6 (t)-6.7 (m)-5.9 (en)10.6 (t)-6.6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 621 502.68 Tm (160)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 1.983 0 Td [(16)-17 (3)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 646.44 498.72 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(N)2.6 (I)-6.6 (FT)-10.6 (P)12.9 ( w)13.5 (as)-2 ( r)-6 (e)]TJ 0 Tc 0 Tw (-)Tj 6.435 0 Td [(cl)4.6 (a)1.7 (ssi)15.4 (f)-15.4 (i)4.6 (e)1.6 (d)12.5 ( )]TJ -0.002 Tc 0.007 Tw -28.587 -1.37 Td [(i)2.6 (n 2016 )]TJ [(t)-6.6 (o)10.5 ( pr)-5.9 (ev)8.9 (ent)4.3 ( ov)8.9 (er)-5.9 (t)-6.6 (r)4.9 (eat)-6.6 (m)-6 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (hi)2.6 (s)-2 ( i)2.6 (ndol)2.6 (en)]TJ [(t)4.3 ( t)4.2 (um)-6 (or)4.9 ( t)-6.6 (y)8.9 (pe as)8.9 ( w)13.5 (el)2.6 (l)2.6 ( as)-2 ( t)-6.6 (he )]TJ 0 -1.38 Td [(ps)-2 (y)8.8 (c)-2 (hol)2.6 (og)-11.2 (i)2.6 (c)-2 (al)2.6 ( )0.5 (c)-2 (ons)-1.9 (e)10.5 (q)-11.2 (ue)10.5 (nc)-2 (es)-2 ( )0.5 (o)10.5 (f)-6.6 ( a)10.6 ( c)-2 (anc)-2 (er)5 ( di)2.6 (a)10.5 (g)-11.2 (nos)8.9 (i)2.6 (s)-2 ( on t)-6.6 (he)10.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.7 (.)]TJ -0.004 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For personal use only. Not approved for distribution. 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2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (11)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.005 Tc 0.01 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(NCCN G)-9.6 (u)]TJ -0.002 Tc -0.004 Tw 4.489 0 Td [(i)2.6 (del)2.6 (i)2.6 (nes)-2 ( f)-17.5 (or)4.9 ( T)-10.6 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d )-10.7 (C)2.7 (ar)-6 (c)-2 (i)2.7 (nom)-6 (a\))4.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 228.96 517.92 Tm (81)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 236.64 513.96 Tm ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(T)-10.6 (he)10.5 ( di)2.6 (ag)-11.2 (nos)-2 (i)2.6 (s)-2 ( )-10.6 (o)10.5 (f)-6.6 ( f)-6.6 (ol)2.6 (l)2.6 (i)2.6 (c)-1.9 (ul)2.6 (ar)-6 ( )]TJ 0.007 Tw -19.587 -1.38 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a )0.5 (i)2.6 (s)-2 ( a)10.5 (s)-2 (s)-2 (i)2.6 (g)-11.2 (ned)10.5 ( onl)2.6 (y)8.9 ( af)-6.6 (t)-6.6 (e)10.5 (r)-5.9 ( anal)2.7 (y)8.8 (s)-2 (i)2.6 (s)-2 ( o)10.6 (f)-17.5 ( )11.3 (t)-6.7 (he )]TJ 0.002 Tw 24.446 0 Td [(pe)10.5 (r)-6 (m)-5.9 (anen)10.5 (t)]TJ 0 Tc 0 Tw 4.761 0 Td ( )Tj -0.002 Tc -0.004 Tw -29.207 -1.37 Td [(hi)2.6 (s)-2 (t)-6.6 (ol)2.6 (og)-11.2 (i)2.6 (c)-2 ( s)-2 (ec)-2 (t)-6.6 (i)2.6 (ons)]TJ 0 Tc 0 Tw 8.098 0 Td <97>Tj -0.002 Tc 0.007 Tw [(ob)10.5 (t)-6.6 (a)10.5 (i)2.6 (ned )11.2 (f)-17.5 (r)-5.9 (o)10.5 (m)-5.9 ( di)2.6 (a)10.6 (g)-11.3 (nos)8.9 (t)-6.6 (i)2.6 (c)-2 ( l)2.6 (obe)10.5 (c)-2 (t)-6.6 (om)-6 (y)8.9 ( o)10.5 (r)-5.9 ( )]TJ 0.005 Tc -0.005 Tw -8.098 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(t)-6.7 (e)10.6 (s)-2 ( )11.2 (f)-17.5 (o)10.6 (r)-6 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( and )11.3 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.7 (ar)-5.9 ( )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-6 (as)-2 ( )]TJ -3.022 -1.38 Td [(ar)-6 (e )0.5 (s)-2.1 (i)2.7 (m)-6 (i)2.6 (l)2.6 (ar)4.9 ( i)2.6 (n pat)-6.6 (i)2.7 (en)10.5 (t)-6.6 (s)-2 ( o)10.5 (f)-6.6 ( )11.3 (c)-2 (om)-5.9 (par)-5.9 (abl)2.6 (e)10.5 ( a)10.5 (g)-11.2 (e and)10.6 ( di)2.6 (s)-2 (eas)-2 (e s)-2 (t)-6.6 (a)10.5 (g)-11.2 (e)10.5 (.)4.3 ( P)1.9 (at)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (i)2.6 (t)-6.6 (h )]TJ 0 -1.37 Td [(ei)2.6 (t)-6.6 (her)-6 ( c)-2 (an)10.6 (c)-2 (er)5 ( hav)8.8 (e an ex)8.9 (c)-2 (el)2.6 (l)2.6 (ent)-6.6 ( pr)-5.9 (o)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)8.9 ( i)13.4 (f)-17.4 ( )11.2 (t)-6.6 (he )11.3 (t)-6.6 (u)10.5 (m)-6 (or)-5.9 (s)]TJ 0 Tc 0 Tw 24.152 0 Td ( )Tj -0.013 Tc 0.018 Tw 0.283 0 Td [(a)-11.3 (r)-17 (e c)-13 (o)-11.3 (nf)-28.5 (i)-8.4 (n)-11.3 (e)-11.4 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(hl)2.6 (e c)-2 (el)2.6 (l)2.6 ( c)-2 (ar)-5.9 (c)-2 (i)2.6 (no)10.5 (m)-6 (a)]TJ -0.006 Tc 0.006 Tw (. )Tj -0.002 Tc 0.007 Tw 0 -1.37 Td [(P)2 (r)-6 (ev)8.8 (i)2.6 (ous)-2 (l)-8.2 (y)8.8 ( c)-2 (ons)-2 (i)2.6 (der)-6 (ed a )11.2 (v)8.9 (ar)-6 (i)2.6 (ant)-6.6 ( o)10.5 (f)-17.4 ( )11.2 (f)-6.6 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( t)-6.7 (hy)8.9 (r)-6 (oi)13.5 (d c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-6 (a,)4.2 ( t)-6.6 (he)10.5 ( )22.1 (W)-36.2 (o)10.5 (r)-6 (l)2.7 (d)10.5 ( )]TJ 0 -1.38 Td [(H)2.6 (eal)2.6 (t)-6.6 (h O)4.2 (r)4.9 (g)-11.2 (ani)2.6 (z)8.9 (at)-6.6 (i)2.6 (on \()15.8 (W)-36.3 (H)24.3 (O)-6.6 (\))5 ( and A)2 (J)-2 (C)2.6 (C)2.6 ( )11.3 (r)-6 (ec)-2 (l)2.6 (as)-2 (s)-2 (i)13.5 (f)-17.5 (i)2.6 (e)10.5 (d )]TJ -0.005 Tc 0.01 Tw [<48fc>-3.4 (r)-8.9 (t)-9.6 (h)-3.4 (le)7.5 ( c)-5 (e)-3.3 (ll c)-5.1 (a)-3.3 (r)-9 (c)-5 (in)-3.3 (o)7.5 (m)-9 (a)]TJ 0 Tc 0 Tw 32.402 0 Td ( )Tj -0.002 Tc 0.007 Tw -32.402 -1.37 Td [(as)-2 ( a s)-2 (epa)10.5 (r)-5.9 (at)-6.6 (e)10.5 ( en)10.5 (t)-6.6 (i)2.6 (t)-6.6 (y)8.9 ( i)2.6 (n 2)10.6 (017)]TJ 0 Tc 0 Tw (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 161.76 177.12 Tm [(9,)-1.9 (171)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 179.04 173.16 Tm ( )Tj -0.002 Tc 0.007 Tw 0.293 0 Td [(M)15.8 (o)-11.2 (l)2.6 (ec)-2 (ul)2.6 (ar)-5.9 ( s)-2 (t)-6.6 (udi)2.6 (e)10.5 (s)-2 ( s)-2 (u)10.5 (gg)-11.2 (es)8.9 (t)]TJ 0 Tc 0 Tw 11.522 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(t)-6.6 (hat)4.3 ( t)-6.7 (hi)2.6 (s)8.9 ( t)-6.6 (u)10.5 (m)-6 (or)4.9 ( )]TJ -26.174 -1.38 Td [(m)-6 (ay)8.9 ( be )]TJ 3.543 0 Td [(m)-6 (or)-6 (e)10.6 ( s)-2 (i)2.6 (m)-6 (i)2.6 (l)2.6 (ar)-6 ( )11.3 (t)-6.6 (o p)10.6 (api)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.7 (han )]TJ [(t)-6.6 (o )11.2 (f)-6.6 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( t)4.2 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-5.9 (a)]TJ 0 Tc 0 Tw (s)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 354.48 161.88 Tm [(172,)-1.8 (17)-17 (3)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 379.56 157.92 Tm ( )Tj -0.002 Tc -0.004 Tw -32.25 -1.37 Td [(and g)-11.2 (enot)-6.6 (y)8.8 (pi)2.6 (ng)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc -0.004 Tw 7.098 0 Td [(r)-6 (ev)8.9 (eal)2.6 (ed )-10.6 (t)-6.6 (ha)10.6 (t)-6.6 ( m)-5.9 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (onal)2.6 (,)-6.6 ( t)-6.7 (r)-5.9 (ans)8.9 (c)-2 (r)-6 (i)13.5 (pt)-6.7 (i)2.6 (onal)2.6 (,)-6.6 ( )-10.6 (and c)-2 (opy)8.9 ( )-10.6 (num)-6 (be)10.5 (r)-5.9 ( )]TJ 0.007 Tw -7.098 -1.38 Td [(pr)-6 (o)10.5 (f)-17.5 (i)2.7 (l)2.6 (es)-2 ( o)10.5 (f)-6.6 ( H)2.6 4.9 (t)-6.6 (hl)2.7 (e c)-2 (el)2.6 (l)2.6 ( c)-2 (a)10.5 (r)-6 (c)-2 (i)2.7 (nom)-6 (as)8.8 ( w)13.5 (er)-6 (e di)2.6 (s)-2 (t)-6.6 (i)2.6 (nc)-2 (t)4.2 ( )11.3 (f)-6.6 (r)4.9 (om)-6 ( papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( and )11.3 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.7 (ar)-5.9 ( )]TJ 0 -1.37 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (as)8.9 (,)-6.6 ( be)10.6 (s)-2 (t)4.2 ( c)-2 (at)-6.6 (e)10.5 (g)-11.2 (o)10.5 (r)-6 (i)2.6 (z)8.9 (i)2.6 (ng)-11.2 ( i)2.7 (t)-6.6 ( as)8.9 ( a uni)13.5 (q)-11.2 (ue)10.6 ( c)-2 (l)2.6 (as)8.9 (s)-2 ( o)10.5 (f)-6.6 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0.002 Tw 0 -1.38 Td [(m)-6 (al)2.6 (i)2.6 (g)-11.2 (nanc)-2 (y)8.8 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 82.32 101.16 Tm (174)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 93.84 97.2 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(B)2 (eni)2.6 (g)-11.2 (n)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 3.391 0 Td [(a)10.5 (nd m)-5.9 (al)2.6 (i)2.6 (gnant)4.2 ( H)2.6 -6 (t)-6.6 (hl)2.6 (e)10.5 ( c)-2 (el)2.7 (l)2.6 ( t)-6.6 (u)10.5 (m)-6 (or)-6 (s)8.9 ( us)]TJ 16.174 0 Td [(ual)2.6 (l)2.6 (y)8.9 ( c)-2 (annot)-6.6 ( b)10.5 (e )]TJ -26.217 -1.37 Td [(di)2.6 (s)-2 (c)-2 (r)-6 (i)2.6 (m)-5.9 (i)2.6 (nat)-6.6 (ed by)8.9 ( FN)2.6 (A)2 ( o)10.5 (r)-6 ( )11.3 (f)-6.6 (r)-6 (oz)8.9 (en s)-2 (ec)8.9 (t)-6.6 (i)2.6 (on ex)8.9 (am)-6 (i)2.6 (nat)-6.6 (i)2.6 (on,)-6.6 ( al)2.6 (t)-6.6 (hou)10.5 (g)-11.2 (h)10.5 ( l)2.6 (ar)4.9 (g)-11.2 (e)10.5 ( \()-6 (>)6 (4 )]TJ 0 -1.38 Td [(c)-2 (m)-6 (\))5 ( t)-6.7 (u)10.6 (m)-6 (or)4.9 (s)-2 ( a)10.5 (r)-6 (e )11.3 (m)-6 (or)-6 (e)10.5 ( l)2.6 (i)2.6 (k)-12.8 (e)10.5 (l)2.6 (y)8.9 ( t)-6.6 (o be )11.3 (m)-6 (al)2.6 (i)2.6 (g)-11.2 (nant)4.2 ( )11.3 (t)-6.6 (han s)8.9 (m)-5.9 (al)2.6 (l)2.6 (er)-6 ( ones)8.8 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 324.48 70.8 Tm (175)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 336 66.84 Tm ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(S)-1 (im)-9 (ila)-3.3 (r)-9 ( t)-9.6 (o)7.5 ( )]TJ 0.005 Tw -28.587 -1.37 Td [(f)-9.6 (o)-3.4 (llic)-5 (u)-3.3 (la)-3.4 (r)-8.9 ( )]TJ -0.002 Tc 0.002 Tw 3.935 0 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ 0.007 Tw 3.272 0 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-6 (a,)4.2 ( t)-6.6 (he)10.5 ( di)2.6 (ag)-11.2 (n)10.5 (os)-2 (i)2.6 (s)-2 ( o)10.5 (f)-6.6 ( H)2.6 4.9 (t)4.2 (hl)2.6 (e c)-2 (el)2.6 (l)2.6 ( c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( i)2.6 (s)-2 ( onl)2.6 (y)8.9 ( )]TJ 27.348 41.87 Td [(as)-2 (s)-2 (i)2.6 (g)-11.2 (ned)10.6 ( a)10.5 (f)-6.6 (t)]TJ 5.38 0 Td [(er)4.9 ( anal)2.6 (y)8.9 (s)-2 (i)2.6 (s)-2 ( of)-6.6 ( )11.2 (t)-6.6 (he )]TJ 0.002 Tw [(pe)10.5 (r)-6 (m)-5.9 (anen)10.6 (t)]TJ 0 Tc 0 Tw 12.576 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(hi)2.6 (s)8.8 (t)-6.6 (ol)2.6 (og)-11.2 (i)13.5 (c)-2 ( s)-2 (ec)8.8 (t)-6.6 (i)2.6 (ons)]TJ 0 Tc 0 Tw 8.076 0 Td <97>Tj -0.002 Tc 0.002 Tw [(obt)-6.6 (ai)2.7 (ned)10.5 ( )]TJ 0.007 Tw -26.315 -1.38 Td [(f)-6.6 (r)-6 (o)10.6 (m)-6 ( di)2.7 (a)10.5 (g)-11.2 (nos)8.9 (t)-6.7 (i)2.7 (c)-2 ( l)2.6 (obec)-2 (t)-6.6 (o)10.5 (m)4.9 (y)8.9 ( or)-6 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (o)10.5 (m)-5.9 (y)]TJ 0 Tc 0 Tw 19.217 0 Td <97>Tj -0.002 Tc 0.007 Tw [(s)-2 (ho)10.6 (w)13.5 (s)-2.1 ( t)-6.6 (um)-6 (or)4.9 ( c)-2 (aps)-2 (ul)2.6 (e )]TJ -19.217 -1.37 Td [(i)2.6 (nv)8.8 (as)-2 (i)2.6 (on b)-11.2 (y)8.9 ( H)2.6 -6 (t)-6.6 (hl)2.6 (e c)-2 (el)2.6 (l)2.6 (s)-2 (.)4.3 ( )]TJ 0 Tc 0 Tw 11.293 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -11.293 -2.38 Td [(H)2.6 -6 (t)-6.6 (hl)2.7 (e c)-2 (el)2.6 (l)2.6 ( c)-2 (a)10.5 (r)-6 (c)-2 (i)2.7 (nom)-6 (as)8.8 ( )11.3 (m)-6 (ay)8.9 ( be a)10.5 (gg)-11.3 (r)-5.9 (e)10.5 (s)-2 (s)-2 (i)2.6 (v)8.9 (e,)-6.6 ( es)-2 (pe)10.5 (c)-1.9 (i)2.6 (al)2.6 (l)-8.2 (y)8.8 ( w)13.5 (hen )-10.5 (v)8.9 (as)-2 (c)-2 (ul)2.6 (ar)-5.9 ( )]TJ 0 -1.37 Td [(i)2.6 (nv)8.8 (as)-2 (i)2.6 (on or)-5.9 ( l)2.6 (ar)-5.9 (g)-11.2 (e)10.5 ( t)-6.6 (u)10.5 (m)-5.9 (o)10.5 (r)-6 (s)-2 ( )11.3 (oc)-2.1 (c)-1.9 (ur)-6 ( i)2.6 (n)10.6 ( ol)2.6 (der)]TJ 0 Tc 0 Tw 16.902 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 636.24 446.16 Tm [(176)-16.9 (,)-1.9 (17)-17 (7)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 661.44 442.2 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)-6.6 (n 2)10.6 ( l)2.6 (ar)5 (g)-11.3 (e s)-2 (e)10.5 (r)-6 (i)2.7 (es)-2 (,)4.3 ( )]TJ -23.511 -1.38 Td [(pul)2.6 (m)-5.9 (onar)-5.9 (y)8.8 ( m)-5.9 (e)10.5 (t)-6.6 (as)-1.9 (t)-6.7 (a)10.6 (s)-2 (es)-2 ( o)10.5 (c)-2 (c)-2 (ur)-6 (r)-5.9 (ed)10.6 ( i)2.7 (n 25)10.5 (%)-4.3 ( and)10.5 ( 35%)6.6 ( o)10.5 (f)-6.6 ( pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( w)13.4 (i)2.6 (t)-6.6 (h H)2.6 -6 (t)-6.6 (hl)2.7 (e)10.5 ( )]TJ 0 -1.37 Td [(c)-2 (el)2.6 (l)2.6 ( c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.6 (,)-6.6 ( abou)10.5 (t)-6.6 ( )11.3 (t)-6.6 (w)13.5 (i)-8.3 (c)-2 (e t)-6.6 (he)10.5 ( )11.3 (f)-6.6 (r)-6 (e)10.5 (q)-11.2 (uenc)-2 (y)8.9 ( o)10.5 (f)-6.6 ( )11.2 (f)-17.4 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (a)10.5 (r)-6 (c)-2 (i)2.7 (nom)-6 (a)10.5 ( )]TJ 0.002 Tw 0 -1.38 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 464.4 400.56 Tm (178)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 1.983 0 Td [(1)-17 (80)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 489.84 396.6 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)-6.6 (n c)-2 (ont)4.3 (r)-5.9 (as)-2 (t)4.3 ( t)-6.6 (o)10.5 ( papi)2.7 (l)2.6 (l)2.6 (a)]TJ [(r)-5.9 (y)8.8 ( or)-6 ( )11.3 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( c)-2 (a)10.5 (r)-6 (c)-2 (i)2.6 (nom)-6 (as)8.9 (,)-6.6 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 722.52 400.56 Tm (131)Tj -0.011 Tc 0.005 Tw 11.04 -0 0 11.04 734.04 396.6 Tm [(I)-15.6 ( m)-14.9 (a)-9.4 (y )]TJ -0.002 Tc 0.007 Tw -29.804 -1.37 Td [(be not)4.3 ( e)10.5 (f)-6.6 (f)-6.6 (ec)-2 (t)-6.6 (i)2.6 (v)8.9 (e i)2.6 (n pa)10.5 (t)-6.6 (i)2.6 (ent)4.2 (s)-1.9 ( w)13.5 (i)2.6 (t)-6.6 (h H)2.6 -5.9 (t)-6.6 (hl)2.6 (e c)-2 (el)2.7 (l)2.6 ( c)-2 (a)10.5 (r)-6 (c)-2 (i)2.6 (n)10.6 (om)-5.9 (a bec)-2 (au)10.5 (s)-2 (e )11.3 (f)-6.6 (ew)13.4 (er)-6 ( )]TJ 0 -1.38 Td [(H)2.6 -6 (t)-6.6 (hl)2.7 (e c)-2 (el)2.6 (l)2.6 ( c)-2 (a)10.5 (r)-6 (c)-2 (i)2.7 (nom)-6 (as)8.8 ( )11.3 (c)-2 (onc)-2 (ent)-6.6 (r)-5.9 (a)10.5 (t)-6.6 (e )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 583.08 370.2 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 594.6 366.24 Tm [(I)-6.6 (.)4.2 ( I)-6.6 (n)10.6 ( a )11.3 (s)-2 (er)-5.9 (i)13.5 (es)-2 ( o)10.5 (f)-6.6 ( 100 pa)10.5 (t)-6.6 (i)2.7 (ent)-6.7 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ -0.004 Tw -17.174 -1.37 Td [(di)2.6 (s)-2 (t)-6.6 (ant)-6.6 ( m)-5.9 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (as)8.9 (es)-2 (,)4.3 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 502.92 355.08 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 514.44 351.12 Tm [(I)-6.6 ( upt)-6.6 (a)10.5 (k)-12.9 (e by)8.9 ( pul)2.6 (m)-5.9 (ona)10.5 (r)-6 (y)8.9 ( m)-5.9 (e)10.5 (t)4.2 (as)-2 (t)-6.6 (as)-2 (es)8.9 ( w)13.5 (as)-2 ( s)-2 (een i)2.7 (n )]TJ 0.004 Tc -0.004 Tw -9.913 -1.38 Td [(mo)5.7 (re)]TJ 0 Tc 0 Tw 2.272 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(t)-6.6 (han)10.5 ( 50%)6.6 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.6 ( )11.2 (f)-6.6 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( \()-6 (64%)6.6 (\))-6 ( and)10.6 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( \()-6 (60%)-4.3 (\))4.9 ( c)-2 (ar)-5.9 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (as)8.9 ( but)4.3 ( )]TJ -2.554 -1.37 Td [(i)2.6 (n onl)2.6 (y)8.9 ( 36%)-4.2 ( o)10.6 (f)-6.6 ( H)2.6 -5.9 (t)-6.6 (hl)2.6 (e)10.5 ( c)-2 (e)10.6 (l)2.6 (l)2.6 ( c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (as)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 594.6 324.72 Tm (178)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 606.12 320.76 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)-6.6 (n t)-6.6 (he)10.5 ( N)13.5 (at)-6.6 (i)2.7 (onal)2.6 ( C)2.6 (anc)-2 (er)-6 ( )]TJ -18.5 -1.38 Td [(D)2.6 (at)-6.6 (abas)-2 (e )11.2 (r)-5.9 (epor)5 (t)-6.6 (,)4.2 ( t)-6.6 (he)10.6 ( 10)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 10.804 0 Td [(y)8.9 (ear)-6 ( r)-5.9 (el)2.6 (at)-6.6 (i)2.6 (v)8.8 (e s)-2 (ur)-5.9 (v)8.9 (i)2.6 (v)8.8 (a)-11.2 (l)2.6 ( r)-5.9 (at)-6.6 (e)10.5 (s)-2 ( w)13.5 (er)-6 (e 85%)6.6 ( )11.2 (f)-17.5 (o)10.6 (r)-6 ( )11.3 (f)-6.6 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( )]TJ -10.804 -1.37 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (as)8.9 ( and 76)10.5 (%)-4.3 ( )11.3 (f)-6.6 (or)4.9 ( )11.3 (H)2.6 -6 (t)-6.6 (hl)2.6 (e c)-2 (el)2.6 (l)2.6 ( c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 638.64 294.36 Tm (181)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 650.16 290.4 Tm ( )Tj 0.283 0 Td ( )Tj EMC /H4 <>BDC /TT2 1 Tf 0.015 Tc 0.001 Tw -22.489 -2.467 Td [(P)8.1 (ri)8.7 (ma)16.6 (ry)15 ( )0.5 (T)6.5 (u)16.6 (mo)16.6 (r)11.1 ( )0.5 (S)8.1 (i)-2.1 (z)36.7 (e)]TJ 0 Tc 0 Tw 8.967 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc -0.004 Tw -8.967 -1.413 Td [(P)2 (T)-10.6 (C)2.6 (s)-2 ( s)-2 (m)-6 (al)2.6 (l)2.6 (er)-5.9 ( t)-6.7 (han)10.6 ( )]TJ 0.004 Tc 0.001 Tw 8.478 0 Td [(1)5.7 ( c)14.9 (m,)10.2 ( t)-0.6 (e)16.5 (rme)5.6 (d)16.6 <2093>]TJ -0.002 Tc 0.002 Tw [(i)2.6 (nc)-2 (i)2.6 (dent)-6.6 (al)2.6 (o)10.5 (m)-5.9 (as)]TJ 0 Tc 0 Tw 13.076 0 Td <94>Tj 0.326 0 Td ( )Tj -0.007 Tc 0.007 Tw 0.283 0 Td [(o)-5.3 (r )]TJ 0 Tc 0 Tw 1.163 0 Td <93>Tj -0.002 Tc 0.002 Tw 0.326 0 Td [(m)-6 (i)2.7 (c)-2 (r)-6 (oc)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (as)]TJ 0.005 Tc -0.005 Tw 7.533 0 Td <2c94>Tj 0 Tc 0 Tw 0.609 0 Td ( )Tj -0.002 Tc 0.007 Tw -31.793 -1.37 Td [(ar)-6 (e )11.3 (t)-6.6 (y)8.9 (pi)2.6 (c)-2 (al)2.6 (l)-8.2 (y)8.8 ( f)-17.5 (ound)10.5 ( i)2.6 (nc)-2 (i)2.6 (dent)-6.7 (al)2.6 (l)2.6 (y)8.9 ( af)-6.6 (t)-6.6 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(;)4.2 ( t)-6.6 (he)10.5 ( 30)]TJ 0 Tc 0 Tw 19 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(y)8.9 (ear)-6 ( c)-2 (anc)-2 (er)]TJ 0 Tc 0 Tw 5.207 0 Td (-)Tj -0.005 Tc -0.001 Tw 0.337 0 Td [(s)-5 (p)7.5 (e)-3.3 (c)-5.1 (i)10.5 (f)-20.5 (ic)-5 ( m)-9 (o)-3.3 (r)1.9 (t)-9.6 (a)-3.4 (lit)-9.6 (y)5.9 ( )]TJ EMC ET endstream endobj 729 0 obj 28374 endobj %% Contents for page 74 %% Original object ID: 149 0 730 0 obj << /Length 731 0 R >> stream Q q BT /Xi72 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. 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(inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (12)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(i)2.6 (s)-2 ( 0.)-6.6 (4%)6.6 ( c)-2 (o)10.5 (m)-6 (par)-5.9 (ed)10.6 ( t)-6.7 (o)10.6 ( 7%)6.6 ( )11.2 (\()]TJ /TT2 1 Tf -0.004 Tc 0.004 Tw 11.413 0 Td (P )Tj /TT0 1 Tf -0.002 Tc 0.007 Tw 0.946 0 Td [(<)5.9 ( .)-6.6 (001)10.5 (\))-5.9 ( )11.2 (f)-6.6 (or)4.9 ( )11.3 (t)-6.6 (um)-5.9 (o)10.5 (r)-6 (s)-2 ( 1)10.6 (.)-6.7 (5 )11.3 (c)-2 (m)-6 ( o)10.5 (r)-5.9 ( l)2.6 (ar)4.9 (g)-11.2 (e)10.6 (r)-6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 330.36 517.92 Tm (11)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 338.04 513.96 Tm ( )Tj -0.006 Tc 0.272 0 Td [(I)-10.6 (n)-4.3 ( f)-10.6 (a)-4.3 (c)-6 (t, )]TJ -0.002 Tc 0.007 Tw -28.761 -1.38 Td [(t)-6.6 (he p)10.5 (r)-5.9 (o)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)-2 ( )11.3 (f)-6.7 (or)4.9 ( papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( and )11.3 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-5.9 (as)8.9 ( i)2.6 (s)-2 ( )]TJ 0 -1.37 Td [(i)2.6 (nc)-2 (r)-6 (em)-6 (ent)4.3 (al)2.6 (l)2.6 (y)8.9 ( poor)-6 (er)-6 ( as)8.8 ( t)4.3 (um)-6 (or)-5.9 (s)8.9 ( i)2.6 (nc)-2 (r)-5.9 (eas)-2 (e)10.5 ( i)2.6 (n s)-2.1 (i)2.7 (z)8.8 (e.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 256.56 487.56 Tm [(170,)-1.8 (1)-17 (86)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 281.64 483.6 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (her)-5.9 (e)10.5 ( i)2.6 (s)-2 ( a l)2.6 (i)2.6 (near)5 ( )]TJ -23.663 -1.38 Td [(r)-6 (el)2.6 (at)-6.6 (i)2.6 (ons)-2 (hi)2.6 (p bet)-6.6 (w)13.5 (een t)-6.6 (u)10.5 (m)5 (or)-6 ( s)-2 (i)2.6 (z)8.9 (e and )11.3 (r)-6 (ec)-2 (ur)5 (r)-6 (enc)-2 (e o)10.5 (r)4.9 ( c)-2 (anc)-2 (er)]TJ 0 Tc 0 Tw 25.424 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(s)-2 (pec)-2 (i)13.5 (f)-17.5 (i)2.6 (c)8.9 ( )]TJ 0.007 Tw -25.761 -1.37 Td [(m)-6 (or)4.9 (t)-6.6 (al)2.6 (i)2.6 (t)-6.6 (y)8.8 ( )11.3 (f)-17.5 (or)4.9 ( bot)-6.6 (h)10.5 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( and )11.3 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.7 (ar)-5.9 ( c)-2 (ar)-6 (c)-1.9 (i)2.6 (no)10.5 (m)5 (as)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 276.72 457.2 Tm (11)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 284.4 453.24 Tm ( )Tj /TT3 1 Tf 12 -0 0 12 287.52 453.24 Tm ( )Tj EMC /H4 <>BDC /TT2 1 Tf 0.009 Tc -0.004 Tw 11.04 -0 0 11.04 23.52 425.88 Tm [(Loc)-1.9 (al)2.7 ( T)0.5 (u)10.6 (m)-5.8 (or)5 ( I)-6.5 (nv)-1.8 (a)10.6 (s)-1.9 (i)2.8 (on)]TJ 0 Tc 0 Tw 9.707 0 Td ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw -9.989 -1.402 Td [(U)2.6 (p t)-6.6 (o 10)10.5 (%)-4.3 ( o)10.5 (f)-6.6 ( )11.3 (di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (at)4.3 (ed t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.5 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (as)8.9 ( i)2.6 (nv)8.8 (ade t)-6.6 (hr)-5.9 (ou)10.5 (g)-11.2 (h )11.3 (t)-6.6 (he ou)10.5 (t)-6.6 (er)4.9 ( )]TJ 0 -1.38 Td [(bor)-6 (der)4.9 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.6 ( )11.2 (g)-11.2 (l)2.6 (and and)10.5 ( )11.3 (g)-11.2 (r)4.9 (ow)13.5 ( di)2.6 (r)-5.9 (ec)-2 (t)-6.7 (l)2.7 (y)8.8 ( i)2.6 (nt)-6.6 (o s)-2 (ur)4.9 (r)-6 (ou)10.5 (ndi)2.6 (ng)-11.2 ( )11.2 (t)-6.6 (i)2.6 (s)-2 (s)-2 (ues)-2 (,)4.3 ( i)2.6 (nc)-2 (r)-6 (eas)-2 (i)2.6 (n)10.5 (g )]TJ 0 -1.37 Td [(bot)-6.6 (h )11.3 (m)-5.9 (or)-5.9 (bi)2.6 (di)2.6 (t)-6.6 (y)8.9 ( and )11.3 (m)-6 (or)4.9 (t)-6.6 (a)10.5 (l)2.6 (i)2.6 (t)-6.6 (y)8.9 (.)-6.6 ( T)-10.6 (he)10.5 ( l)2.6 (oc)-2 (al)2.6 ( i)2.6 (nv)8.8 (as)-2 (i)2.6 (on m)-6 (ay)8.9 ( be m)-6 (i)2.6 (c)-2 (r)-5.9 (os)8.9 (c)-2 (opi)]TJ -0.007 Tc 0.012 Tw 29.359 0 Td [(c)-7 ( o)-5.4 (r )]TJ -0.002 Tc 0.007 Tw -29.359 -1.38 Td [(g)-11.2 (r)4.9 (os)-2 (s)-1.9 (;)4.2 ( i)2.6 (t)4.3 ( c)-2 (an oc)8.9 (c)-2 (ur)4.9 ( w)13.4 (i)2.7 (t)-6.7 (h bot)-6.6 (h papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( and )11.2 (f)-17.4 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-6 (as)8.8 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 331.2 368.76 Tm [(11,)-1.8 (18)-17 (7)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 352.44 364.8 Tm ( )Tj -0.002 Tc 0.007 Tw -29.793 -1.37 Td [(R)2.6 (ec)-2 (ur)-5.9 (r)-6 (enc)-2 (e)10.5 ( r)-5.9 (a)10.5 (t)-6.6 (es)-2 ( a)10.6 (r)-6 (e 2)10.5 ( )11.3 (t)-6.7 (i)2.6 (m)-5.9 (es)-2 ( )0.5 (hi)13.5 (g)-11.2 (he)10.5 (r)-5.9 ( w)13.4 (i)2.7 (t)-6.6 (h l)2.6 (oc)-2 (al)2.6 (l)2.6 (y)8.9 ( i)2.6 (n)-11.2 (v)8.9 (as)-2 (i)-8.2 (v)8.8 (e t)-6.6 (um)-5.9 (or)5 (s)-2.1 (,)4.3 ( and as)8.9 ( )]TJ 0 -1.38 Td [(m)-6 (any)8.9 ( as)-2 ( 33)10.6 (%)-4.4 ( o)10.6 (f)-6.7 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h s)-2 (uc)-2 (h t)-6.6 (u)10.5 (m)-5.9 (o)10.5 (r)-5.9 (s)-2 ( di)2.6 (e o)10.5 (f)-6.6 ( )22.1 (c)-2 (anc)-2 (er)-6 ( w)13.5 (i)2.6 (t)-6.6 (hi)2.6 (n a )]TJ 0.002 Tw 0 -1.37 Td [(dec)-2 (ade.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 62.76 323.28 Tm [(11,)-1.8 (18)-17 (8)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 84 319.32 Tm ( )Tj 0.283 0 Td ( )Tj EMC /H4 <>BDC /TT2 1 Tf 0.009 Tc 0.007 Tw -5.761 -2.467 Td [(Ly)-1.9 (m)-5.8 (p)10.7 (h )0.6 (N)13.6 (ode)10.7 ( )0.5 (M)5.1 (et)-6.5 (a)10.6 (s)-1.8 (t)4.4 (as)-1.9 (e)10.6 (s)-1.8 ( )]TJ 0 Tc 0 Tw 11.5 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw -11.5 -1.413 Td [(I)-6.6 (n one)10.6 ( r)-6 (ev)8.8 (i)2.7 (ew)13.5 (,)-6.6 ( nod)]TJ [(al)2.6 ( m)-6 (et)4.2 (as)-2 (t)-6.6 (as)-2.1 (es)8.9 ( w)13.5 (er)-5.9 (e )11.3 (f)-17.5 (ound)10.6 ( i)2.6 (n 36)10.5 (%)-4.3 ( o)10.5 (f)-6.6 ( 8029)10.5 ( adul)2.6 (t)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ 0 -1.38 Td [(papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( c)-2 (ar)-5.9 (c)-2.1 (i)2.7 (nom)-6 (a,)-6.6 ( i)2.6 (n )11.3 (1)10.5 (7%)-4.3 ( o)10.5 (f)-6.6 ( 1540)10.6 ( pat)-6.6 (i)2.7 (ent)4.2 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h )11.2 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.37 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (,)-6.6 ( and)10.5 ( i)2.6 (n up)10.5 ( t)-6.6 (o)10.5 ( )11.3 (80%)-4.3 ( o)10.5 (f)-6.6 ( c)-2 (hi)2.6 (l)2.6 (dr)-5.9 (en)10.6 ( w)13.4 (i)2.7 (t)-6.7 (h papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( )0.5 (c)-2.1 (ar)-6 (c)-2 (i)2.7 (nom)-6 (a.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 340.32 250.08 Tm (132)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 351.84 246.12 Tm ( )Tj -0.004 Tc 0.004 Tw 0.283 0 Td [(An)-2.4 ( )]TJ -0.002 Tc 0.007 Tw -30.022 -1.38 Td [(enl)2.6 (ar)-6 (g)-11.2 (ed)10.6 ( c)-2 (er)-5.9 (v)8.8 (i)2.7 (c)-2 (al)2.6 ( l)2.6 (y)8.9 (m)-6 (ph )11.3 (node m)-5.9 (ay)8.9 ( be )11.3 (t)-6.7 (he)10.5 ( onl)2.6 (y)8.9 ( s)-2 (i)2.6 (gn o)10.5 (f)-6.6 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.6 (.)-6.7 ( )]TJ -0.004 Tw 0 -1.37 Td [(I)-6.6 (n t)-6.6 (hes)-2 (e )-10.7 (pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 (,)-6.6 ( m)-6 (ul)2.6 (t)-6.6 (i)2.6 (pl)2.6 (e )-10.6 (noda)]TJ 0.007 Tw [(l)2.6 ( m)-5.9 (e)10.5 (t)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 ( ar)-5.9 (e)10.5 ( )11.2 (us)-2 (ual)2.6 (l)2.6 (y)8.9 ( f)-17.5 (ound a)10.5 (t)-6.6 ( )]TJ 0.002 Tw 0 -1.38 Td [(s)-2 (ur)4.9 (g)-11.3 (er)-5.9 (y)8.8 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 63.36 204.48 Tm (189)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 74.88 200.52 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (he)10.5 ( pr)-6 (o)10.5 (g)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)-2 ( i)2.6 (m)-6 (por)5 (t)-6.6 (anc)-2 (e)10.5 ( o)10.5 (f)-6.6 ( r)-6 (e)10.6 (g)-11.2 (i)2.6 (onal)2.6 ( )11.3 (l)2.6 (y)8.9 (m)-6 (ph node m)-5.9 (e)10.5 (t)-6.6 (as)-1.9 (t)-6.7 (a)10.6 (s)-2 (es)-2 ( )]TJ -4.935 -1.37 Td [(i)2.6 (s)-2 ( c)-2 (ont)4.3 (r)-6 (ov)8.8 (er)-6 (s)-1.9 (i)2.6 (al)]TJ 0 Tc 0 Tw 6.641 0 Td (.)Tj 6.96 -0 0 6.96 99.96 189.36 Tm (3)Tj 11.04 -0 0 11.04 103.8 185.4 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(H)2.6 (ow)13.4 (e)-11.2 (v)-2 (er)-6 (,)4.3 ( an anal)2.7 (y)8.8 (s)-2 (i)2.6 (s)-2 ( o)10.6 (f)-6.7 ( m)-5.9 (o)10.5 (r)-6 (e )11.3 (t)4.2 (han 9900 pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( i)2.6 (n t)-6.6 (he)10.6 ( )]TJ -7.554 -1.38 Td [(S)2 (E)1.9 (E)2 (R)2.6 ( dat)-6.6 (abas)-2 (e )11.2 (f)-6.6 (ound a)10.5 ( )11.3 (s)-2.1 (i)2.7 (g)-11.3 (ni)13.5 (f)-17.5 (i)2.6 (c)-2 (ant)4.3 ( di)13.5 (f)-6.6 (f)-6.6 (er)-5.9 (enc)-2 (e)]TJ 0 Tc 0 Tw 20.054 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (n s)8.8 (ur)-6 (v)8.9 (i)-8.3 (v)8.9 (al)2.6 ( at)-6.6 ( 14 y)8.9 (ear)-6 (s)8.9 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )]TJ -20.337 -1.37 Td [(t)-6.6 (hos)-2 (e w)13.4 (i)2.6 (t)-6.6 (h and w)13.5 (i)2.6 (t)-6.6 (hout)-6.6 ( l)2.6 (y)8.8 (m)-5.9 (ph node)10.5 ( m)-6 (e)10.5 (t)-6.6 (as)8.9 (t)-6.7 (as)-2 (es)8.8 ( \()-5.9 (7)10.5 (9%)-4.3 ( )]TJ -0.011 Tc 0.011 Tw [(vs)-11 (.)-15.6 ( )]TJ -0.013 Tc 0.013 Tw 25.109 0 Td [(8)-11.3 (2%)-15.3 (,)-6.8 ( )]TJ -0.002 Tc 0.002 Tw -25.109 -1.38 Td [(r)-6 (es)-2 (pec)-2 (t)-6.6 (i)2.6 (v)8.9 (el)2.6 (y)8.9 (\))-6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 88.32 143.76 Tm (190)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 99.84 139.8 Tm ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(O)-6.6 (l)2.6 (der)-5.9 ( )-10.7 (pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( \()-6 (>)]TJ 0.007 Tw 7.413 0 Td [(45)10.5 ( y)8.8 (ear)-5.9 (s)-2 (\))4.9 ( w)13.5 (i)2.6 (t)-6.6 (h)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 6.467 0 Td [(papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( c)-2 (ar)-6 (c)-2 (i)2.7 (nom)-6 (a )]TJ 0.002 Tw (and )Tj 0.007 Tw -21.076 -1.37 Td [(l)2.6 (y)8.9 (m)-6 (ph node m)-5.9 (e)10.5 (t)-6.6 (as)-1.9 (t)-6.7 (a)10.6 (s)-2 (es)-2 ( )11.3 (al)2.6 (s)-2 (o hav)8.9 (e dec)-2 (r)-5.9 (eas)-2 (ed)10.6 ( s)-2 (ur)4.9 (v)8.9 (i)-8.3 (v)8.9 (al)2.6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 287.64 128.64 Tm [(1)-17 (91)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 299.28 124.68 Tm ( )Tj -0.004 Tc 0.004 Tw 0.283 0 Td (A )Tj -0.002 Tc 0.002 Tw 0.946 0 Td (2012)Tj 0 Tc 0 Tw ( )Tj -0.011 Tc 0.016 Tw 2.5 0 Td [(r)-15 (e)-9.3 (vi)-6.4 (e)-20.3 (w)4.5 ( b)-9.3 (y )]TJ -0.002 Tc 0.007 Tw -28.707 -1.38 Td [(R)2.6 (andol)2.6 (ph et)]TJ 0 Tc 0 Tw 5.38 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(al)2.6 ( e)10.5 (m)-6 (phas)-2 (i)2.6 (z)8.9 (ed t)-6.6 (he)10.5 ( c)-2 (or)4.9 (r)-6 (el)2.6 (at)-6.6 (i)2.6 (on be)10.5 (t)-6.6 (w)13.5 (een t)-6.6 (he)10.5 ( s)-2 (i)2.6 (z)8.9 (e and num)-5.9 (be)10.5 (r)-5.9 ( )]TJ -0.004 Tw -5.663 -1.37 Td [(o)10.5 (f)-17.5 ( m)-5.9 (et)-6.6 (as)8.9 (t)-6.6 (a)10.5 (t)-6.6 (i)2.7 (c)-2 ( )-10.7 (l)2.7 (y)8.8 (m)-5.9 (ph )-10.6 (node)10.5 (s)-2 ( )-10.6 (and t)-6.6 (he r)-5.9 (i)2.6 (s)8.8 (k)-12.8 ( )-10.6 (o)10.5 (f)-6.6 ( r)-6 (ec)-2 (u)10.5 (r)-6 (r)-5.9 (en)10.6 (c)-2.1 (e.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 282.24 98.28 Tm (192)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 293.76 94.32 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)-6.6 (dent)-6.6 (i)13.5 (f)-17.5 (i)2.7 (c)-2 (a)10.5 (t)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( )]TJ -24.761 -1.38 Td [(f)-6.6 (ew)13.5 (er)-6 ( t)-6.6 (han 5)10.5 ( s)-2 (ub)]TJ 0 Tc 0 Tw 7.37 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(c)-2 (m)4.9 ( )11.3 (m)-6 (et)4.2 (as)-2 (t)-6.6 (at)-6.6 (i)2.6 (c)8.9 ( l)2.6 (y)8.9 (m)-6 (ph nodes)-2 ( w)13.5 (as)-2 ( as)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.7 (ed)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h )0.5 (a l)2.6 (ow)13.4 ( )]TJ -7.707 -1.37 Td [(r)-6 (i)2.7 (s)-2 (k)-2 ( o)10.5 (f)-6.6 ( )11.2 (r)-5.9 (ec)-2 (ur)4.9 (r)-6 (enc)-2 (e.)4.3 ( C)2.6 (onv)8.8 (er)-6 (s)-2 (el)2.6 (y)8.9 (,)-6.6 ( s)-2 (t)4.2 (r)-5.9 (uc)-2 (t)-6.6 (u)10.6 (r)-6 (al)2.6 ( )0.5 (di)2.6 (s)-2 (eas)-2 (e)10.5 ( )0.5 (r)-6 (ec)-2 (u)10.6 (r)-6 (r)-5.9 (enc)-2 (e)10.5 ( r)-6 (a)10.6 (t)-6.7 (es)8.9 ( o)10.5 (f)-6.6 ( m)-6 (o)10.5 (r)5 (e )]TJ 0.002 Tw 34.554 40.761 Td [(t)-6.6 (han )]TJ 0.007 Tw 2.228 0 Td [(20)10.5 (%)-4.3 ( )11.2 (t)-6.6 (o 30)10.6 (%)-4.4 ( w)13.5 (er)-6 (e s)8.8 (een)]TJ 0 Tc 0 Tw ( )Tj -0.005 Tc 0.01 Tw 10.522 0 Td [(in)-3.3 ( la)-3.3 (r)1.9 (g)-14.2 (e)]TJ 0 Tc 0 Tw 3.272 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(v)8.9 (ol)2.6 (um)-6 (e l)2.6 (y)8.9 (m)4.9 (ph node )11.3 (m)-6 (et)-6.5 (a)10.5 (s)-2 (t)-6.6 (as)-2 (es)8.8 ( \()5 (>)-5 (3 )]TJ -0.007 Tc 0.012 Tw -16.359 -1.38 Td [(c)-7 (m)-11 (,)-0.7 ( o)-5.4 (r >)-9.9 (5)]TJ 0 Tc 0 Tw 4.196 0 Td <96>Tj -0.002 Tc 0.007 Tw 0.554 0 Td [(10)10.5 ( i)2.6 (nv)8.9 (ol)2.7 (v)8.8 (ed l)-8.2 (y)-2 (m)-6 (ph nodes)8.8 (\))-5.9 (.)]TJ 0 Tc 0 Tw 11.565 0 Td ( )Tj 0.272 0 Td ( )Tj EMC /H4 <>BDC /TT2 1 Tf 0.009 Tc 0.007 Tw -16.587 -2.467 Td [(D)2.7 (i)2.8 (s)-1.9 (t)-6.5 (an)10.7 (t)4.4 ( )0.5 (M)5.1 (et)-6.5 (a)10.7 (s)-1.9 (t)4.4 (as)-1.8 (es)]TJ 0 Tc 0 Tw 8.641 0 Td ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.005 Tc 0.005 Tw -8.924 -1.413 Td (Dis)Tj -0.002 Tc 0.007 Tw 1.435 0 Td [(t)-6.6 (ant)-6.6 ( )11.3 (m)-6 (et)-6.7 (a)10.6 (s)-2 (t)-6.6 (as)-2 (es)8.8 ( ar)-6 (e)10.6 ( )11.2 (t)4.3 (he pr)-5.9 (i)2.6 (nc)-2 (i)2.6 (pal)2.6 ( c)-2 (aus)-2 (e)10.5 ( o)10.5 (f)-6.6 ( dea)10.5 (t)-6.6 (h )11.3 (f)-6.7 (r)-5.9 (o)10.5 (m)-5.9 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( and )]TJ -1.435 -1.37 Td [(f)-6.6 (ol)2.7 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 507.84 444.72 Tm [(193,)-1.8 (1)-17 (94)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 532.92 440.76 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 (bout)-6.6 ( 50%)6.6 ( o)10.5 (f)-6.6 ( t)-6.6 (hes)-2 (e)10.5 ( )11.3 (m)4.9 (et)-6.7 (as)-2 (t)-6.6 (as)-2 (e)10.6 (s)-2 ( a)10.6 (r)-6 (e )]TJ [(p)10.5 (r)-6 (es)-2 (ent)4.3 ( at)4.3 ( )]TJ -0.004 Tw -11.87 -1.38 Td [(t)-6.6 (he t)-6.6 (i)2.6 (m)-6 (e )-10.6 (o)10.5 (f)-6.6 ( di)2.6 (ag)-11.3 (nos)-2 (i)2.7 (s)8.8 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 509.04 429.48 Tm (132)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 520.56 425.52 Tm ( )Tj -0.005 Tc 0.005 Tw 0.283 0 Td [(Dis)-5 (t)]TJ -0.002 Tc 0.007 Tw 1.717 0 Td [(ant)-6.6 ( )11.3 (m)-6 (et)-6.7 (a)10.6 (s)-2 (t)-6.6 (as)-2 (es)8.9 ( oc)-2 (c)-2 (u)10.5 (r)-5.9 ( ev)8.9 (en m)-6 (o)10.6 (r)-6 (e o)10.6 (f)-6.6 (t)-6.6 (e)10.5 (n i)2.6 (n )]TJ -12.467 -1.37 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h H)2.6 4.9 (t)-6.6 (hl)2.6 (e c)-2 (el)2.6 (l)2.6 ( )11.3 (c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.5 ( \()-5.9 (35)10.6 (%)-4.3 (\))4.9 ( and i)2.6 (n )11.3 (t)4.2 (hos)-2 (e pat)-6.6 (i)2.6 (ent)4.2 (s)-2 ( w)13.5 (ho ar)-6 (e)10.5 ( )]TJ 0 -1.38 Td [(ol)2.6 (der)-6 ( t)-6.6 (han)10.5 ( a)10.6 (g)-11.3 (e 40)10.6 ( y)8.9 (ear)-5.9 (s)-2 ( )11.3 (at)-6.6 ( di)2.7 (a)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 585.6 399.12 Tm [(178,)-1.8 (17)-17 (9)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 610.68 395.16 Tm ( )Tj 0.283 0 Td (A)Tj -0.002 Tc 0.002 Tw 0.663 0 Td [(m)-6 (ong)]TJ 0 Tc 0 Tw ( )Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 651.84 399.12 Tm (123)Tj -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 663.36 395.16 Tm (1 )Tj 0.007 Tw 0.837 0 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( i)2.6 (n 13)10.5 ( )]TJ 0.002 Tw -24.239 -1.37 Td [(s)-2 (t)-6.6 (udi)2.6 (es)]TJ 0 Tc 0 Tw 3.163 0 Td (,)Tj 0.272 0 Td ( )Tj 0.283 0 Td (t)Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(he)10.5 ( s)-2 (i)2.6 (t)-6.6 (es)8.9 ( o)]TJ 4.25 0 Td [(f)-6.6 ( r)-6 (epo)10.6 (r)-6 (t)-6.6 (ed)10.6 ( di)2.6 (s)-2 (t)-6.6 (ant)4.3 ( )11.3 (m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 ( )11.2 (w)13.5 (er)-6 (e l)2.6 (ung)-11.3 ( )11.3 (\()-5.9 (49%)-4.3 (\))4.9 (,)4.2 ( bone )]TJ -8.25 -1.38 Td [(\()-6 (25%)-4.2 (\))4.9 (,)4.2 ( bot)-6.6 (h)10.6 ( l)2.7 (ung and bo)10.5 (ne \()-5.9 (15)10.6 (%)-4.4 (\))5 (,)-6.6 ( and)10.5 ( t)-6.6 (he)10.5 ( )0.5 (c)-2 (ent)4.2 (r)-5.9 (a)10.5 (l)2.6 ( ner)-5.9 (v)8.8 (ous)-2 ( s)-2 (y)8.9 (s)-2 (t)-6.6 (em)5 ( \()-6 (C)2.6 (N)2.6 (S)2 (\))4.9 ( )]TJ 0 -1.37 Td [(or)-6 ( o)10.5 (t)-6.6 (her)4.9 ( s)-2 (o)10.6 (f)-6.7 (t)-6.6 ( )11.3 (t)-6.6 (i)2.6 (s)-2 (s)-2 (ues)8.9 ( \()]TJ -0.004 Tw 9.315 0 Td [(10)10.6 (%)-4.3 (\))-6 (.)4.3 ( T)-10.5 (he)]TJ 0 Tc 0 Tw 4.587 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(m)-6 (ai)2.6 (n p)10.5 (r)-6 (edi)2.6 (c)-1.9 (t)-6.7 (o)10.6 (r)-6 (s)-2 ( )11.3 (o)10.5 (f)-17.5 ( ou)10.5 (t)-6.6 (c)-2 (om)-5.9 (e)10.5 ( )11.3 (f)-6.6 (or)4.9 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( )]TJ -0.004 Tw -14.185 -1.38 Td [(w)2.6 (i)2.6 (t)-6.6 (h )-10.6 (di)2.6 (s)-2 (t)-6.6 (ant)4.3 ( m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.8 ( ar)-6 (e )]TJ -0.013 Tc 0.018 Tw 12.359 0 Td [(p)-11.3 (at)-17.6 (i)-8.4 (e)-11.4 (n)-11.3 (t)-17.6 <92>-8.4 (s)-13 ( ag)-22.2 (e,)]TJ 0 Tc 0 Tw 5.924 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(t)-6.6 (he s)-2 (i)13.5 (t)4.2 (e o)10.5 (f)-6.6 ( t)-6.6 (he)10.6 ( di)]TJ 0.005 Tc -0.005 Tw 7.033 0 Td [(s)5 (ta)6.7 (n)17.5 (t )]TJ -0.002 Tc -0.004 Tw -25.587 -1.37 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (i)2.6 (s)-2 (,)4.2 ( )-10.6 (and )-10.6 (w)13.5 (het)-6.6 (her)4.9 ( t)-6.7 (he m)-6 (et)-6.6 (as)8.8 (t)-6.6 (as)-2 (es)8.9 ( )]TJ 0.002 Tw 18.12 0 Td [(c)-2 (onc)-2 (en)10.5 (t)-6.6 (r)4.9 (at)-6.6 (e )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 665.64 323.28 Tm (131)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 677.16 319.32 Tm (I)Tj 0.283 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 683.4 323.28 Tm [(178,)-1.8 (1)-17 (79,)-19.1 (19)-16.9 (5,)-1.8 (1)-17 (96)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 735.72 319.32 Tm ( )Tj 0.293 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -30.25 -2.37 Td [(A)2 (l)2.6 (t)-6.6 (houg)-11.2 (h)10.5 ( s)-2 (om)-6 (e)10.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 (,)4.3 ( )11.3 (es)-2 (pec)-2 (i)2.6 (al)2.6 (l)-8.3 (y)8.9 ( y)8.9 (oung)-11.2 (er)-5.9 ( ones)8.8 (,)4.3 ( w)13.5 (i)2.6 (t)-6.6 (h di)2.6 (s)-2 (t)-6.6 (ant)-6.6 ( )11.2 (m)-5.9 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (a)10.6 (s)-2 (es)-2 ( )]TJ 0 -1.38 Td [(s)-2 (ur)-6 (v)8.9 (i)2.6 (v)8.9 (e f)-17.5 (or)4.9 ( dec)-2 (ades)8.8 (,)-6.6 ( abo)10.5 (ut)-6.6 ( 50)10.6 (%)-4.3 ( di)2.6 (e w)13.4 (i)2.7 (t)-6.7 (hi)2.6 (n 5 y)8.9 (ear)-6 (s)8.9 ( r)-6 (e)10.6 (g)-11.3 (a)10.6 (r)-6 (dl)2.6 (es)-2 (s)-2 ( o)10.6 (f)-6.7 ( )11.3 (t)-6.6 (um)-5.9 (o)10.5 (r)-5.9 ( )]TJ 0.002 Tw 0 -1.37 Td [(hi)2.6 (s)-2 (t)-6.6 (ol)2.6 (og)-11.2 (y)8.8 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 451.56 266.76 Tm (132)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 463.08 262.8 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(E)2 (v)8.8 (en s)-2 (o,)-6.6 ( s)-2 (o)10.5 (m)-6 (e pul)2.6 (m)-6 (o)10.6 (nar)-6 (y)8.9 ( m)-6 (e)10.6 (t)-6.7 (as)8.9 (t)-6.6 (as)8.9 (es)-2 ( )0.5 (ar)-6 (e)10.6 ( c)-2 (o)10.5 (m)-6 (pat)-6.6 (i)2.6 (bl)2.6 (e w)13.4 (i)2.6 (t)-6.6 (h )]TJ 0.002 Tw -5.543 -1.38 Td [(l)2.6 (ong)]TJ 0 Tc 0 Tw 1.891 0 Td (-)Tj -0.011 Tc 0.016 Tw 0.326 0 Td [(t)-15.6 (e)-9.4 (r)-4 (m)-15 ( su)-9.4 (r)-15 (vi)-6.4 (va)-9.4 (l)-6.4 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 494.76 251.52 Tm [(1)-17 (97)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 506.4 247.56 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(For)-6 ( ex)8.9 (am)-6 (pl)2.6 (e,)-6.6 ( one)10.6 ( s)-1.9 (t)-6.6 (udy)8.8 ( )11.3 (f)-6.6 (ou)10.6 (nd t)-6.7 (ha)10.5 (t)-6.6 ( w)13.5 (hen di)2.6 (s)-2 (t)-6.6 (ant)4.3 ( )]TJ 0.002 Tw -9.467 -1.37 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 ( )]TJ 0.007 Tw 5.38 0 Td [(w)13.5 (er)-5.9 (e c)-2 (on)10.5 (f)-17.5 (i)2.6 (ne)10.5 (d t)-6.6 (o)10.5 ( t)-6.6 (he)10.5 ( l)2.6 (ung,)-6.6 ( )11.3 (m)-6 (o)10.5 (r)-5.9 (e )11.3 (t)-6.6 (han )11.3 (50%)-4.3 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (he pa)10.6 (t)-6.7 (i)2.7 (ent)-6.6 (s)8.8 ( w)13.5 (er)-6 (e )]TJ -5.38 -1.38 Td [(al)2.6 (i)-8.3 (v)8.9 (e and )11.3 (f)-6.7 (r)-5.9 (ee o)10.5 (f)-6.6 ( di)2.6 (s)-2 (eas)-2 (e)10.5 ( )11.3 (at)-6.6 ( 10)10.5 ( y)8.8 (ear)-6 (s)-2 (,)4.3 ( w)13.4 (her)-5.9 (eas)-2 ( no )11.3 (pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.7 (h s)8.9 (k)-12.9 (el)2.6 (et)-6.6 (al)13.4 ( )]TJ 0 -1.37 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 ( s)-2 (ur)-5.9 (v)8.9 (i)2.6 (v)8.8 (ed t)-6.6 (hat)4.3 ( l)2.6 (ong.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 553.68 206.04 Tm (198)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 565.2 202.08 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (he )11.3 (s)-2 (ur)-6 (v)8.9 (i)2.6 (v)8.8 (al)2.6 ( r)-5.9 (at)-6.6 (es)-2 ( ar)-6 (e)10.6 ( hi)2.6 (g)-11.2 (he)10.5 (s)-2 (t)4.3 ( i)2.6 (n y)8.9 (oung )]TJ -14.793 -1.38 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h di)13.5 (f)-6.6 (f)-6.6 (us)-2 (e l)2.6 (un)10.6 (g m)-6 (e)10.6 (t)-6.7 (as)-2 (t)-6.6 (a)10.5 (s)-2 (es)-2 ( s)-2 (ee)10.6 (n onl)2.6 (y)8.9 ( )]TJ 0.002 Tw (on )Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 653.4 190.8 Tm (131)Tj -0.005 Tc 0.01 Tw 11.04 -0 0 11.04 664.92 186.84 Tm [(I)-9.6 ( im)-9 (a)7.5 (g)-14.2 (in)-3.3 (g)]TJ 0 Tc 0 Tw 4.054 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(and no)10.5 (t)-6.6 ( on)10.5 ( )]TJ 0 Tc 0 Tw -27.88 -1.37 Td (x)Tj 0.489 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(r)-6 (ay)]TJ 0 Tc 0 Tw 1.38 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 432.48 175.68 Tm [(19)-17 (6,)-1.9 (1)-16.9 (98,)-19.1 (19)-17 (9)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 471.36 171.72 Tm ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(P)2 (r)-6 (og)-11.3 (nos)-2 (i)2.7 (s)8.8 ( i)2.6 (s)-2 ( )-10.6 (w)13.5 (or)-5.9 (s)-2 (e)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 8.641 0 Td [(w)13.5 (i)2.6 (t)-6.6 (h l)2.6 (ar)-6 (g)-11.2 (e)10.6 ( pul)2.7 (m)4.9 (onar)-5.9 (y)8.9 ( m)-5.9 (et)-6.7 (a)10.6 (s)-2 (t)-6.7 (as)-2 (es)8.8 ( )11.3 (t)-6.6 (hat)4.3 ( d)10.5 (o )]TJ -14.935 -1.38 Td [(not)-6.6 ( c)-2 (onc)-2 (en)10.6 (t)-6.6 (r)-6 (a)10.5 (t)-6.6 (e)10.5 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 483.96 160.44 Tm (131)Tj 0.005 Tc -0.005 Tw 11.04 -0 0 11.04 495.48 156.48 Tm (I.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 501.72 160.44 Tm [(178,)-19.1 (17)-17 (9)-16.9 (,)-1.9 (19)-17 (5)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 540.6 156.48 Tm ( )Tj 0.283 0 Td ( )Tj EMC /H2 <>BDC /TT1 1 Tf 0.009 Tc 0.007 Tw -12.565 -2.391 Td [(T)11.3 (u)0.5 (m)-4.2 (or)-4.2 ( )0.6 (S)12.9 (t)-5.8 (ag)11.3 (i)-6.5 (n)0.5 (g)11.3 ( )]TJ 0 Tc 0 Tw 7.435 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -7.435 -1.696 Td (T)Tj 0.62 0 Td (h)Tj 0.554 0 Td (e)Tj 0.543 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(N)2.6 (C)2.6 (C)2.6 (N)2.6 ( G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )11.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d C)2.6 (ar)-5.9 (c)-2 (i)2.6 (no)10.6 (m)-6 (a do)10.5 ( )11.3 (not)-6.6 ( us)-2 (e)10.6 ( )11.2 (T)-10.5 (N)2.6 (M)15.8 ( s)-2.1 (t)-6.6 (a)10.6 (g)-11.2 (es)-2 ( as)8.8 ( )]TJ -2 -1.38 Td [(t)-6.6 (he p)10.5 (r)-5.9 (i)2.6 (m)-6 (ar)-6 (y)8.9 ( de)10.5 (t)-6.6 (er)4.9 (m)-5.9 (i)2.6 (nant)-6.6 ( )11.3 (o)10.5 (f)-17.5 ( )11.3 (m)-6 (ana)10.6 (g)-11.2 (em)-5.9 (en)10.5 (t)4.3 (.)-6.6 ( )11.3 (I)-6.7 (ns)-2 (t)-6.6 (ead)10.5 (,)4.3 ( m)-6 (any)8.9 ( c)-2 (ha)10.6 (r)-6 (ac)-2 (t)-6.6 (e)10.5 (r)-6 (i)2.6 (s)-2 (t)-6.6 (i)2.6 (c)-2 (s)8.9 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.37 Td [(t)-6.6 (he )11.3 (t)-6.7 (um)-5.9 (o)10.5 (r)-6 ( and)10.5 ( pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 ( pl)2.6 (a)10.5 (y)8.9 ( i)2.6 (m)-6 (por)-5.9 (t)-6.6 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stream Q q BT /Xi73 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 738 0 obj 245 endobj %% Contents for page 76 %% Original object ID: 152 0 739 0 obj << /Length 740 0 R >> stream q endstream endobj 740 0 obj 2 endobj %% Contents for page 76 %% Original object ID: 11408 0 741 0 obj << /Length 742 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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Tc 0 Tw 11.04 -0 0 11.04 177.96 422.88 Tm ( )Tj EMC /H2 <>BDC /TT1 1 Tf 0.009 Tc 0.007 Tw -13.989 -2.402 Td [(P)2.1 (r)-4.2 (o)0.5 (gno)0.5 (s)10.6 (t)5.1 (i)-6.5 (c)10.7 ( )0.5 (S)2.1 (cor)6.7 (i)-6.5 (n)0.5 (g)11.2 ( )0.6 (S)12.9 (t)-5.8 (r)6.7 (at)-5.8 (eg)11.3 (i)-6.5 (es)10.6 ( )]TJ 0 Tc 0 Tw 14.837 0 Td ( )Tj EMC ET /P <>BDC BT /TT0 1 Tf -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 377.64 Tm [(S)2 (ev)8.9 (er)-5.9 (al)2.6 ( s)-2 (t)-6.6 (ag)-11.2 (i)2.6 (n)10.5 (g )0.5 (and c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( pr)-6 (o)10.6 (g)-11.3 (nos)8.8 (t)-6.6 (i)2.6 (c)-2 ( s)-2 (c)-2 (o)10.6 (r)-6 (i)2.6 (ng s)8.9 (t)-6.6 (r)4.9 (at)-6.6 (e)10.6 (g)-11.3 (i)2.6 (es)-2 ( us)-2 (e)10.5 ( pat)-6.6 (i)2.6 (ent)4.3 ( a)10.5 (g)-11.3 (e)10.6 ( )]TJ 0 -1.37 Td [(ol)2.6 (der)-6 ( t)-6.6 (han)10.5 ( 40 y)8.9 (ear)-6 (s)8.9 ( as)-2 ( a)10.5 ( )11.3 (m)-6 (aj)-8.2 (o)10.5 (r)-5.9 ( )11.2 (f)-6.6 (eat)-6.6 (u)10.6 (r)-6 (e )11.3 (t)-6.6 (o i)2.6 (den)10.5 (t)-6.6 (i)13.5 (f)-17.5 (y)8.8 ( )11.3 (c)-2 (anc)-2 (er)-6 ( )]TJ -0.005 Tc -0.001 Tw 24.924 0 Td [(m)-9 (o)-3.3 (r)1.9 (t)-9.6 (a)-3.4 (lit)-9.6 (y)5.9 ( )-10.6 (r)-9 (is)5.9 (k)-15.9 ( f)-9.6 (r)1.9 (o)7.6 (m)-9 ( )]TJ -0.002 Tc -0.004 Tw -24.924 -1.38 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d )]TJ 0.002 Tw 9.315 0 Td [(c)-2 (a)10.5 (r)4.9 (c)-2 (i)2.7 (nom)-6 (a.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 180.12 351.24 Tm [(130,)-1.8 (13)-17 (6,)-19.1 (201)]TJ 0 Tc 0 Tw 5.569 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.328 0 Td [(2)-17 (03)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 232.8 347.28 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (hes)8.9 (e s)-2 (t)4.2 (r)-5.9 (at)-6.6 (e)10.5 (g)-11.2 (i)2.6 (es)8.8 ( )0.5 (i)2.6 (nc)-2 (l)2.6 (ude t)-6.6 (he)10.6 ( )]TJ -0.005 Tc -0.001 Tw -19.239 -1.37 Td [(E)-1 (O)-9.7 (RT)-13.5 (C)10.5 (,)-9.7 ( T)-13.6 (NM)12.8 ( )-10.6 (7)]TJ -0.002 Tc 0.002 Tw 6.96 -0 0 6.96 101.16 336.12 Tm (th)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 106.92 332.16 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(edi)2.6 (t)-6.6 (i)2.6 (on,)-6.6 ( A)2 (M)15.8 (E)1.9 (S)2 ( \()]TJ 0 Tc 0 Tw 6.924 0 Td (A)Tj -0.006 Tc 0.006 Tw 0.663 0 Td [(g)-15.2 (e)-4.4 (, )]TJ 0 Tc 0 Tw 1.674 0 Td (M)Tj -0.002 Tc 0.002 Tw 0.815 0 Td [(et)-6.6 (as)-2 (t)-6.6 (as)-2 (e)10.6 (s)-2 (,)-6.6 ( )]TJ 0 Tc 0 Tw 4.837 0 Td (E)Tj -0.002 Tc 0.007 Tw 0.663 0 Td [(x)8.9 (t)-6.6 (ent)4.2 (,)-6.6 ( and)10.6 ( )]TJ 0 Tc 0 Tw (S)Tj -0.002 Tc 0.007 Tw 5.315 0 Td [(i)2.6 (z)8.9 (e\))-5.9 (,)-6.6 ( and)10.5 ( )]TJ ET 186.48 330.12 7.32 0.84 re f 212.28 330.12 9 0.84 re f 274.68 330.12 7.32 0.84 re f 333.36 330.12 7.32 0.84 re f BT -0.004 Tc 0.009 Tw 11.04 -0 0 11.04 23.52 316.92 Tm [(AG)-8.7 (ES \()]TJ 0 Tc 0 Tw 3.391 0 Td (A)Tj -0.013 Tc 0.007 Tw 0.652 0 Td [(g)-22.2 (e,)-17.6 ( t)-17.7 (u)-11.3 (m)-17 (or)-17 ( )]TJ 0 Tc 0 Tw (G)Tj -0.002 Tc 0.002 Tw 5.261 0 Td [(r)-6 (ad)10.5 (e,)-6.6 ( )]TJ 0 Tc 0 Tw 2.554 0 Td (E)Tj -0.002 Tc 0.007 Tw 0.663 0 Td [(x)8.9 (t)-6.6 (ent)4.2 (,)-6.6 ( and)10.6 ( )]TJ 0 Tc 0 Tw (S)Tj -0.002 Tc -0.004 Tw 5.315 0 Td [(i)2.6 (z)8.9 (e\))-5.9 (.)-6.6 ( )-10.6 (A)1.9 (l)2.6 (l)2.6 ( o)10.5 (f)-17.4 ( t)-6.6 (hes)-2 (e s)-2 (t)4.3 (r)-6 (at)-6.6 (e)10.5 (g)-11.2 (i)2.6 (es)-2 ( )]TJ ET 60.96 314.88 7.2 0.84 re f 117.72 314.88 8.52 0.84 re f 154.44 314.88 7.32 0.84 re f 213.12 314.88 7.32 0.84 re f BT -0.011 Tc 0.011 Tw 11.04 -0 0 11.04 23.52 301.8 Tm [(e)1.5 (f)-15.6 (f)-26.5 (e)-9.3 (ct)-15.6 (i)-6.3 (ve)-9.3 (l)-17.3 (y )]TJ -0.002 Tc 0.007 Tw 4.707 0 Td [(di)2.6 (s)-2 (t)-6.6 (i)2.6 (ng)-11.2 (ui)2.6 (s)-2 (h be)10.5 (t)4.2 (w)13.5 (een pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( at)4.3 ( l)2.6 (ow)13.4 ( )0.5 (and hi)2.6 (g)-11.3 (h)10.6 ( r)-6 (i)2.6 (s)8.9 (k)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 314.04 305.76 Tm (186)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 325.56 301.8 Tm ( )Tj -0.016 Tc 0.016 Tw 0.261 0 Td [(W)-50.3 (it)-20.6 (h)-14.4 ( )]TJ -0.002 Tc -0.004 Tw -27.62 -1.38 Td [(i)2.6 (nc)-2 (r)-6 (em)-6 (ent)4.3 (al)2.6 (l)2.6 (y)8.9 ( )-21.5 (w)13.5 (or)-6 (s)-2 (eni)2.6 (ng)-11.2 ( M)4.9 (A)2 (C)2.6 (I)-6.6 (S)2 ( )-10.6 (\()]TJ 0 Tc 0 Tw 14.739 0 Td (M)Tj -0.002 Tc 0.002 Tw 0.815 0 Td [(et)-6.7 (as)-2 (t)-6.6 (as)-2 (i)2.7 (s)-2 (,)4.2 ( )]TJ 0 Tc 0 Tw 4.5 0 Td (A)Tj -0.013 Tc 0.013 Tw 0.663 0 Td [(g)-22.2 (e,)-17.6 ( )]TJ 0 Tc 0 Tw 1.674 0 Td (C)Tj -0.002 Tc 0.007 Tw 0.717 0 Td [(o)10.5 (m)-5.9 (pl)2.6 (et)-6.6 (enes)-2 (s)8.9 ( o)10.5 (f)-6.6 ( )]TJ ET 186.24 284.52 9 0.841 re f 244.92 284.52 7.321 0.841 re f 270.72 284.52 7.92 0.841 re f BT 0.002 Tw 11.04 -0 0 11.04 23.52 271.44 Tm [(r)-6 (es)-2 (ec)-1.9 (t)-6.7 (i)2.7 (on)10.5 (,)-6.6 ( )]TJ 0 Tc 0 Tw 4.598 0 Td (I)Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(nv)8.8 (as)-2 (i)2.6 (on,)-6.6 ( and )]TJ 0 Tc 0 Tw 5.924 0 Td (S)Tj -0.002 Tc 0.007 Tw 0.663 0 Td [(i)2.6 (z)8.9 (e\))-5.9 ( s)-2 (c)-2 (or)-5.9 (es)-2 ( o)10.6 (f)-6.7 ( l)2.7 (es)-2 (s)8.9 ( )]TJ [(t)-6.6 (han)10.5 ( 6,)4.3 ( 6 )11.3 (t)-6.6 (o 6)10.5 (.)-6.6 (99,)4.2 ( 7 )11.3 (t)-6.7 (o 7)10.5 (.)-6.6 (99)10.5 (,)-6.6 ( )]TJ ET 74.28 269.4 3.12 0.841 re f 142.8 269.4 7.32 0.841 re f BT 11.04 -0 0 11.04 23.52 256.2 Tm [(and 8+)5.9 (,)-6.6 ( how)13.5 (ev)8.9 (er)-6 (,)-6.6 ( t)-6.6 (he)10.6 ( 20)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 11.054 0 Td [(y)8.9 (ear)-6 ( s)-2 (ur)-6 (v)8.9 (i)2.6 (v)8.9 (a)-11.2 (l)2.6 ( r)-6 (at)-6.6 (es)8.9 ( w)13.5 (er)-6 (e )11.3 (99%)-4.3 (,)4.2 ( 89%)6.6 (,)-6.6 ( 56)10.6 (%)-4.3 (,)4.2 ( and )]TJ -11.054 -1.37 Td [(24%)-4.3 (,)4.3 ( r)-6 (es)-2 (pec)8.8 (t)-6.6 (i)2.6 (v)8.9 (el)2.6 (y)8.8 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 112.68 245.04 Tm [(1)-17 (36)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 124.32 241.08 Tm ( )Tj 0.293 0 Td ( )Tj ET EMC BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 214.92 Tm [(U)2.6 (nf)-17.5 (o)10.5 (r)-5.9 (t)-6.7 (una)10.6 (t)-6.6 (el)2.6 (y)8.9 (,)-6.6 ( a )11.3 (s)-2 (t)-6.6 (udy)8.9 ( t)-6.6 (h)10.5 (at)-6.6 ( c)-2 (l)2.7 (as)-2 (s)-2 (i)13.5 (f)-17.5 (i)2.6 (ed)10.5 ( 269 pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a )]TJ 0 -1.38 Td [(ac)-2 (c)-2 (or)-5.9 (di)2.6 (n)10.5 (g)-11.2 ( )11.3 (t)-6.6 (o 5)10.6 ( di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)4.2 ( p)10.6 (r)-6 (o)10.5 (g)-11.2 (nos)-2 (t)-6.6 (i)2.6 (c)8.9 ( par)-6 (adi)13.5 (g)-11.2 (m)4.9 (s)-2 ( )11.3 (f)-6.6 (ou)10.6 (nd t)-6.7 (ha)10.5 (t)-6.6 ( s)-2 (o)10.5 (m)-5.9 (e)10.5 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( i)2.6 (n )]TJ 0 -1.37 Td [(t)-6.6 (he l)2.6 (ow)13.4 (es)-2 (t)]TJ 0 Tc 0 Tw 4.489 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(r)-6 (i)2.7 (s)8.8 (k)-2 ( g)-11.2 (r)-6 (oup)10.6 ( f)-6.6 (r)-5.9 (o)10.5 (m)-6 ( )-10.6 (eac)-2 (h)10.6 ( )]TJ 0.007 Tw 9.359 0 Td [(appr)-6 (oa)10.5 (c)-2 (h di)2.6 (ed o)10.5 (f)4.3 ( c)-2 (anc)-2 (er)5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 301.2 188.52 Tm (139)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 312.72 184.56 Tm ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(T)-13.6 (h)-3.3 (is)-5 ( is)5.8 ( )]TJ -0.002 Tc 0.007 Tw -26.478 -1.38 Td [(par)-6 (t)-6.6 (i)2.7 (c)-2 (ul)2.6 (ar)-6 (l)2.6 (y)8.9 ( t)-6.6 (r)-6 (ue)10.5 ( o)10.5 (f)-6.6 ( c)-2 (l)2.6 (as)-2 (s)-2 (i)13.5 (f)-6.7 (i)2.7 (c)-2 (at)-6.6 (i)2.6 (on s)-2 (c)-2 (he)10.5 (m)-6 (es)-2 ( )11.3 (t)-6.6 (hat)4.2 ( s)-2 (i)2.6 (m)5 (pl)2.6 (y)8.9 ( c)-2 (at)-6.6 (eg)-11.2 (o)10.5 (r)-6 (i)2.6 (z)8.9 (e pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( )]TJ -0.005 Tc 0.005 Tw 0 -1.37 Td [(d)-3.3 (ic)-5 (h)]TJ -0.002 Tc 0.007 Tw 1.826 0 Td [(ot)-6.7 (om)-6 (ous)-1.9 (l)2.6 (y)8.8 ( as)-2 ( l)2.6 (ow)13.5 ( or)-6 ( )11.3 (hi)2.6 (g)-11.2 (h )11.2 (r)-5.9 (i)2.6 (s)8.9 (k)-12.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 188.16 158.16 Tm [(201,)-1.8 (20)-17 (4)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 213.24 154.2 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (he A)2 (J)]TJ -0.013 Tc 0.018 Tw 3.174 0 Td [(C)2.5 (C)-8.4 ( T)-21.6 (N)-8.4 (M)4.8 ( s)-13 (t)-17.6 (ag)-22.2 (i)-8.4 (ng)-22.2 ( a)-11.4 (p)-11.3 (pr)-16.9 (o)-11.4 (a)-11.3 (c)-13 (h )]TJ -0.002 Tc 0.007 Tw -20.641 -1.38 Td [(\()-6 (s)-2 (ee )11.3 (T)-10.5 (abl)2.6 (e 1)10.5 ( i)2.7 (n )11.3 (t)-6.6 (he N)2.6 (C)2.6 (C)13.5 (N)2.6 ( G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )11.2 (f)-17.5 (o)10.6 (r)-6 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )11.3 (C)2.6 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a\))4.9 (,)-6.6 ( w)13.5 (hi)2.6 (c)-2 (h i)2.6 (s)-2 ( )]TJ 0 -1.37 Td [(per)-6 (haps)-2 ( )11.3 (t)-6.6 (he )11.2 (m)-5.9 (os)8.9 (t)-6.6 ( w)13.5 (i)2.6 (del)-8.3 (y)8.9 ( us)-2.1 (ed i)2.6 (ndi)2.6 (c)-2 (at)-6.6 (or)4.9 ( o)10.5 (f)-6.6 ( pr)-6 (o)10.5 (g)-11.2 (no)10.5 (s)-2 (i)2.6 (s)-2 (,)-6.6 ( c)-2 (l)2.6 (as)-2 (s)-2 (i)13.5 (f)-17.4 (i)2.6 (es)8.9 ( t)-6.6 (u)10.5 (m)-5.9 (or)-5.9 (s)8.8 ( i)2.6 (n )]TJ 0 -1.38 Td [(al)2.6 (l)2.6 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( y)8.8 (oung)-11.2 (e)10.5 (r)4.9 ( t)-6.6 (han)10.6 ( )]TJ 0.002 Tw (55)Tj 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 12.533 0 Td [(y)8.9 (ear)-6 (s)-2 ( a)10.5 (s)-2 ( s)8.9 (t)-6.6 (a)10.5 (g)-11.2 (e )11.2 (I)-6.6 ( )11.3 (or)5 ( s)-2 (t)4.3 (ag)-11.2 (e)10.5 ( I)4.2 (I)-6.6 (,)4.3 ( ev)8.9 (en t)-6.6 (hos)-2 (e)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ -0.004 Tw -12.533 -1.37 Td [(di)2.6 (s)-2 (t)-6.6 (ant)-6.6 ( m)-5.9 (e)10.5 (t)-6.6 (as)-2 (t)]TJ 0.007 Tw 6.217 0 Td [(as)8.8 (es)-2 (.)4.3 ( A)2 (l)2.6 (t)-6.6 (h)10.5 (oug)-11.2 (h)10.5 ( i)2.6 (t)-6.6 ( p)10.6 (r)-6 (edi)2.6 (c)-2 (t)-6.6 (s)8.9 ( c)-2 (anc)-2 (e)10.5 (r)-5.9 ( )11.2 (m)-5.9 (or)4.9 (t)-6.6 (al)2.6 (i)2.6 (t)-6.6 (y)8.9 ( r)-5.9 (eas)-2 (onabl)2.6 (y)8.9 ( )]TJ -0.005 Tc 0.005 Tw -6.217 -1.38 Td [(w)10.5 (e)-14.3 (ll,)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 45.48 82.2 Tm [(20)-17 (5,)-1.9 (2)-16.9 (06)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 70.68 78.24 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (N)2.6 (M)15.8 ( s)-2 (t)-6.6 (ag)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( )11.2 (w)13.5 (as)-2 ( not)-6.6 ( es)-2 (t)-6.6 (abl)2.6 (i)2.6 (s)-2 (hed a)10.5 (s)-2 ( a)10.5 ( pr)-6 (edi)2.7 (c)-2 (t)-6.7 (o)10.6 (r)-6 ( o)10.5 (f)-6.6 ( )11.3 (r)-6 (ec)-2 (u)10.5 (r)-5.9 (r)-6 (enc)-2 (e)10.5 ( )]TJ -4.554 -1.37 Td [(and t)-6.7 (he)10.5 (r)-5.9 (e)10.5 (f)-17.5 (o)10.5 (r)-5.9 (e does)8.9 ( not)4.2 ( a)10.5 (c)-2 (c)-2 (ur)-6 (at)-6.6 (el)2.6 (y)8.9 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 (ec)-2 (as)8.8 (t)-6.5 ( )11.2 (t)-6.6 (he )11.3 (r)-6 (e)10.6 (c)-2.1 (ur)-6 (r)-5.9 (enc)-2 (es)8.9 ( )11.3 (t)-6.6 (hat)4.2 ( o)10.6 (f)-6.6 (t)-6.6 (en )]TJ 0 -1.38 Td [(oc)-2 (c)-2 (ur)-5.9 ( i)2.6 (n)10.5 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (ho dev)8.9 (el)2.6 (oped t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a w)13.5 (hen t)-6.6 (hey)8.8 ( w)13.5 (er)-6 (e y)8.8 (oung)-11.2 (.)4.2 ( )]TJ 34.554 42.217 Td [(T)-10.6 (w)13.5 (o s)-2 (t)-6.6 (udi)2.6 (es)-2 ( hav)8.9 (e s)-2 (how)13.4 (n t)-6.6 (he)10.5 ( p)]TJ [(oor)4.9 ( pr)-6 (edi)2.6 (c)8.9 (t)-6.6 (i)2.6 (v)8.9 (e v)8.9 (al)2.7 (u)-11.3 (e o)10.5 (f)-6.6 ( m)-6 (os)8.9 (t)-6.6 ( )11.2 (s)-2 (t)-6.6 (a)10.5 (g)-11.2 (i)2.7 (n)10.5 (g)-11.3 ( )]TJ 0 -1.38 Td [(appr)-6 (oac)-2 (hes)-2 ( )11.3 (f)-6.6 (or)4.9 ( )11.3 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)8.9 (ar)-6 (c)-2 (i)2.7 (nom)-6 (a,)4.2 ( i)2.6 (nc)-2 (l)2.6 (udi)2.6 (ng t)-6.6 (he)10.5 ( )11.3 (T)-10.6 (N)2.6 (M)15.8 ( s)-2 (y)8.8 (s)-2 (t)-6.6 (em)-6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 704.04 502.68 Tm [(130,)-1.8 (20)-17 (7)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 729.12 498.72 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -29.641 -2.37 Td [(A)2 ( t)-6.7 (hr)-6 (ee)]TJ 0 Tc 0 Tw 3.217 0 Td (-)Tj -0.013 Tc 0.018 Tw 0.337 0 Td [(t)-17.6 (i)-8.4 (er)-16.9 (e)-11.4 (d)-11.3 ( s)-2.2 (t)-17.6 (ag)-22.2 (i)-8.4 (ng)-22.3 ( s)-13 (y)-2.1 (s)-13 (t)-17.6 (e)-11.4 (m)]TJ 0 Tc 0 Tw 9.413 0 Td <97>Tj -0.016 Tc 0.016 Tw [(l)-11.4 (o)-14.4 (w,)-20.6 ( )]TJ -0.002 Tc 0.007 Tw 3.043 0 Td [(i)2.6 (nt)-6.6 (er)-5.9 (m)-6 (e)10.5 (di)2.6 (at)-6.6 (e,)4.2 ( hi)2.6 (g)-11.2 (h)]TJ 0 Tc 0 Tw 7.924 0 Td <97>Tj -0.013 Tc 0.018 Tw [(t)-17.6 (h)-11.4 (at)-17.6 ( u)-11.4 (s)-13 (es)-13 ( )]TJ -0.002 Tc 0.007 Tw -23.935 -1.38 Td [(c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (opat)-6.6 (hol)2.6 (og)-11.2 (i)2.6 (c)-2 ( )11.3 (f)-17.5 (ea)10.6 (t)-6.6 (ur)-6 (e)10.6 (s)-2 ( t)-6.6 (o)10.5 ( r)-6 (i)2.6 (s)8.9 (k)-2 ( s)-2 (t)4.3 (r)-6 (at)-6.6 (i)13.4 (f)-17.4 (y)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h r)-6 (e)10.5 (g)-11.2 (a)10.5 (r)-5.9 (d )11.3 (t)-6.6 (o )11.3 (t)-6.6 (he )11.3 (r)-6 (i)2.6 (s)8.9 (k)-12.9 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.37 Td [(r)-6 (ec)-2 (ur)5 (r)-6 (enc)-2 (e ha)10.6 (s)-2 ( been)10.5 ( )]TJ 0.002 Tw [(s)-2 (u)10.6 (gg)-11.2 (es)8.9 (t)-6.6 (ed)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 14.304 0 Td [(and)10.5 ( v)8.9 (al)2.7 (i)2.6 (dat)-6.6 (ed)]TJ 0 Tc 0 Tw (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 631.32 446.16 Tm [(3,)-1.9 (20)-17 (8)]TJ 0 Tc 0 Tw 2.517 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.328 0 Td [(21)-17 (1)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 662.76 442.2 Tm ( )Tj 0.009 Tc -0.009 Tw 0.283 0 Td (Th)Tj -0.013 Tc 0.018 Tw 1.174 0 Td [(i)-8.4 (s)-13 ( s)-2.1 (t)-17.6 (ag)-22.2 (i)-8.4 (ng)-22.2 ( s)-13 (y)-2.2 (s)-13 (t)-17.6 (em)-16.9 ( )]TJ -0.002 Tc 0.007 Tw -24.804 -1.38 Td [(e)10.5 (f)-6.6 (f)-17.5 (ec)8.9 (t)-6.6 (i)2.6 (v)8.8 (el)-8.3 (y)8.9 ( r)-6 (i)2.7 (s)-2 (k)-2 ( s)8.8 (t)-6.6 (r)-6 (a)10.6 (t)-6.6 (i)13.4 (f)-17.4 (i)2.6 (es)-2 ( p)10.5 (at)-6.6 (i)2.6 (ent)]TJ 0 Tc 0 Tw 13.522 0 Td (s)Tj ( )Tj -0.013 Tc 0.018 Tw 0.783 0 Td [(w)2.5 (i)-8.4 (t)-17.6 (h)-11.4 ( r)-16.9 (eg)-22.2 (ar)-17 (d)-11.3 ( )11.3 (t)-17.7 (o t)-17.6 (h)-11.4 (e r)-16.9 (i)-8.4 (s)-2.2 (k)-23.8 ( )11.2 (of)-17.6 ( r)-17 (e)-11.4 (c)-13 (ur)-17 (r)-17 (e)-11.3 (n)-11.4 (c)-13 (e,)-17.6 ( )11.2 (r)-16.9 (i)-8.4 (s)-2.2 (k)-23.8 ( )]TJ -0.002 Tc 0.007 Tw -14.304 -1.37 Td [(o)10.5 (f)-17.5 ( pe)10.5 (r)-5.9 (s)-2 (i)2.6 (s)-2 (t)-6.6 (en)10.5 (t)-6.6 ( di)2.6 (s)-2 (eas)-2 (e)10.5 ( a)10.6 (f)-6.7 (t)-6.6 (e)10.5 (r)-5.9 ( i)2.6 (ni)2.6 (t)-6.6 (i)2.6 (al)2.6 ( t)-6.6 (he)10.5 (r)-6 (apy)8.9 (,)-6.6 ( r)-6 (i)2.7 (s)8.8 (k)-2 ( o)10.6 (f)-6.7 ( ha)10.5 (v)8.9 (i)2.6 (ng)-11.2 ( per)-5.9 (s)-2 (i)2.6 (s)-2 (t)-6.6 (en)10.6 (t)-6.7 ( )]TJ 0 -1.38 Td [(s)-2 (t)-6.6 (r)-6 (uc)8.9 (t)-6.7 (ur)-5.9 (al)13.5 ( di)2.6 (s)-2 (eas)-1.9 (e,)4.3 ( l)2.6 (i)2.6 (k)-12.9 (el)2.6 (i)2.6 (hood o)10.5 (f)-6.6 ( ac)-2 (hi)2.6 (ev)8.9 (i)2.6 (ng)-11.2 ( r)-6 (e)10.6 (m)-6 (i)2.6 (s)-2 (s)-2 (i)13.5 (on i)2.6 (n r)-6 (es)-2 (pon)10.5 (s)-2 (e )11.3 (t)-6.6 (o )0.5 (i)2.6 (ni)2.6 (t)-6.6 (i)2.6 (al)2.6 ( )]TJ 0.002 Tw 0 -1.37 Td [(t)-6.6 (her)-6 (apy)8.9 (,)-6.6 ( )]TJ 0.007 Tw 3.891 0 Td [(and)10.5 ( l)2.6 (i)2.7 (k)-12.9 (el)2.6 (i)2.7 (hood o)10.5 (f)4.2 ( bei)2.7 (ng i)2.6 (n r)-5.9 (e)10.5 (m)-6 (i)2.6 (s)-2 (s)-1.9 (i)2.6 (on a)10.6 (t)-6.6 ( )11.2 (f)-17.4 (i)2.6 (n)10.5 (al)2.7 ( )11.2 (f)-17.5 (ol)2.6 (l)2.6 (ow)]TJ 0 Tc 0 Tw 21.522 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td (up.)Tj 0 Tc 0 Tw 1.391 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)-6.6 (n ano)10.6 (t)-6.6 (he)10.5 (r)-5.9 ( )]TJ -27.424 -1.38 Td [(appr)-6 (oac)-2 (h,)4.2 ( em)-6 (pha)10.6 (s)-2.1 (i)2.6 (s)-1.9 ( has)8.8 ( been pl)2.6 (ac)-2 (ed)10.5 ( on ev)8.9 (al)2.6 (uat)-6.6 (i)2.6 (on o)10.6 (f)-6.7 ( r)-5.9 (es)-2 (pons)8.9 (e )11.3 (t)-6.6 (o )]TJ 0 -1.37 Td [(t)-6.6 (her)-6 (apy)8.9 ( us)-2 (i)2.6 (n)10.5 (g)-11.2 ( a)10.5 ( dy)8.9 (nam)-5.9 (i)2.6 (c)-2 ( )11.2 (r)-5.9 (i)2.6 (s)-2 (k)-2 ( as)-2 (s)-2 (es)8.9 (s)-2 (m)-6 (en)10.5 (t)-6.6 ( app)10.5 (r)-5.9 (oac)8.8 (h i)2.6 (n w)13.4 (hi)2.6 (c)-2 (h )0.5 (t)-6.7 (he )0.5 (i)2.5 (ni)2.6 (t)-6.6 (i)2.6 (al)2.6 ( r)-6 (i)2.6 (s)8.9 (k)-2 ( )]TJ 0.002 Tw 0 -1.38 Td [(es)-2 (t)-6.7 (i)2.7 (m)-6 (a)10.5 (t)-6.6 (es)]TJ 0 Tc 0 Tw 4.272 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(a)10.5 (r)-5.9 (e m)-6 (odi)13.5 (f)-17.5 (i)2.6 (ed )-10.7 (d)10.6 (ur)-5.9 (i)2.6 (ng f)-17.4 (ol)2.6 (l)2.6 (ow)]TJ 0 Tc 0 Tw 11.337 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up as)-2.1 ( addi)2.6 (t)-6.6 (i)]TJ 5.109 0 Td [(o)10.5 (nal)2.6 ( dat)-6.6 (a a)10.5 (r)-5.9 (e )]TJ 0.002 Tw -21.337 -1.37 Td [(ac)-2 (c)-2 (um)-6 (ul)2.6 (at)-6.6 (ed)]TJ 0 Tc 0 Tw 5.652 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 470.52 324.72 Tm (212)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 482.04 320.76 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (hi)2.6 (s)-2 ( al)2.7 (l)2.6 (o)10.5 (w)13.5 (s)-2 ( ong)-11.3 (oi)2.6 (ng r)-5.9 (e)]TJ 0 Tc 0 Tw 9.913 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(as)-2 (s)-2 (es)-2 (s)8.9 (m)-6 (e)10.6 (nt)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (r)-6 (i)2.6 (s)8.9 (k)-12.9 ( and)10.6 ( al)2.6 (l)]TJ 11.457 0 Td [(ow)13.4 (s)-2 ( t)-6.6 (he )]TJ -28.967 -1.38 Td [(m)-6 (ana)10.6 (g)-11.2 (em)-5.9 (en)10.5 (t)-6.6 ( pa)10.5 (r)-6 (adi)13.4 (g)-11.2 (m)4.9 ( t)4.3 (o be be)10.5 (t)-6.6 (t)-6.6 (e)10.5 (r)-5.9 ( )11.2 (t)-6.6 (ai)2.6 (l)2.6 (or)-5.9 (ed )11.3 (t)-6.7 (o )11.3 (r)-6 (e)10.5 (al)2.6 (i)2.6 (s)-2 (t)-6.6 (i)2.6 (c)-2 ( es)-2 (t)-6.6 (i)2.6 (m)-6 (a)10.5 (t)-6.6 (es)8.9 ( o)10.5 (f)-6.6 ( r)-6 (i)2.6 (s)8.9 (k)-2 ( )]TJ 0 -1.37 Td [(t)-6.6 (hat)4.3 ( m)-6 (ay)8.9 ( c)-2 (han)10.6 (g)-11.3 (e)10.5 ( s)-1.9 (ubs)8.8 (t)-6.6 (a)10.5 (nt)-6.6 (i)2.6 (al)2.6 (l)2.6 (y)8.9 ( o)-11.2 (v)8.9 (er)-6 ( t)-6.6 (i)2.6 (m)-6 (e)10.6 (.)-6.6 ( )]TJ 0 Tc 0 Tw 18.054 0 Td ( )Tj EMC /H2 <>BDC /TT1 1 Tf 0.009 Tc 0.007 Tw -18.054 -2.391 Td [(S)2.1 (ur)-4.1 (g)11.3 (i)-6.5 (ca)10.6 (l)-6.5 ( )11.4 (M)-5.8 (an)11.3 (age)10.7 (m)-4.2 (en)11.3 (t)-5.8 ( )11.4 (of)5.1 ( )0.5 (D)2.8 (i)4.3 (f)-5.8 (f)5.1 (er)-4.2 (en)11.3 (t)5 (i)-6.5 (a)10.7 (t)-5.8 (ed)11.3 ( )0.5 (T)11.3 (h)-10.4 (y)21.5 (r)-4.2 (o)0.5 (i)-6.5 (d)11.3 ( )0.5 (C)2.8 (ar)-4.1 (c)10.6 (i)-6.5 (n)0.5 (o)11.3 (m)-4.2 (a)]TJ 0 Tc 0 Tw 28.076 0 Td ( )Tj 0.283 0 Td ( )Tj EMC /H3 <>BDC /TT3 1 Tf 0.016 Tc -0.005 Tw 9.96 -0 0 9.96 405 246 Tm [(I)4.9 (ps)5.8 (i)4.8 (l)4.9 (a)5.7 (te)5.8 (r)7.4 (a)5.7 (l)4.9 ( L)0.5 (o)0.5 (b)0.5 (e)5.8 (c)5.7 (to)0.5 (m)1.4 (y)5.8 ( V)8.3 (e)5.8 (r)7.4 (s)5.7 (u)0.5 (s)5.8 ( T)0.5 (o)0.5 (ta)5.7 (l)4.9 ( Th)0.5 (y)5.8 (r)7.4 (o)0.5 (i)4.9 (d)0.5 (e)5.7 (c)5.7 (to)0.6 (m)13.4 (y)]TJ 0 Tc 0 Tw 24.59 0 Td ( )Tj 0.289 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 230.76 Tm [(T)-10.6 (he)10.5 ( appr)-6 (op)10.5 (r)-6 (i)2.7 (at)-6.6 (e ex)8.9 (t)-6.6 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( )]TJ 11.413 0 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d r)-6 (es)-2 (ec)8.9 (t)-6.6 (i)2.6 (on)]TJ 0 Tc 0 Tw <97>Tj -0.002 Tc 0.007 Tw [(i)2.6 (ps)-2 (i)2.6 (l)2.6 (at)-6.6 (er)-6 (al)2.6 ( l)2.6 (obec)8.8 (t)-6.6 (om)-6 (y)8.9 ( v)8.9 (er)-5.9 (s)-2 (us)-2 ( )]TJ -0.004 Tw -11.413 -1.38 Td [(t)-6.6 (ot)-6.6 (al)2.6 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (dec)-2 (t)-6.6 (om)-5.9 (y)]TJ 0 Tc 0 Tw 8.37 0 Td <97>Tj -0.002 Tc 0.007 Tw [(i)2.6 (s)-2 ( v)8.9 (er)-5.9 (y)8.9 ( c)-2 (ont)-6.5 (r)-6 (ov)8.9 (er)-6 (s)-2 (i)2.6 (al)2.6 ( )11.3 (f)-6.6 (or)4.9 ( l)2.6 (ow)13.5 (e)-11.3 (r)]TJ 0 Tc 0 Tw 13.902 0 Td (-)Tj -0.005 Tc 0.01 Tw 0.337 0 Td [(r)-9 (is)5.9 (k)-5 ( p)-3.4 (a)-3.3 (p)-3.4 (illa)-3.3 (r)-9 (y)5.9 ( )]TJ -0.002 Tc 0.007 Tw -22.609 -1.37 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (,)-6.6 ( w)13.5 (hi)2.6 (c)-2 (h i)2.6 (s)-2 ( r)-6 (e)10.5 (f)-17.4 (l)2.6 (e)10.5 (c)-2 (t)-6.6 (ed i)2.6 (n )11.3 (t)-6.6 (he)10.5 ( N)2.6 (C)2.6 (C)2.6 (N)2.6 ( c)-2 (at)-6.6 (e)10.5 (g)-11.2 (o)10.5 (r)-6 (y)8.9 ( 2B)1.9 ( r)-5.9 (ec)-2 (o)10.5 (m)5 (m)-6 (endat)-6.6 (i)2.6 (ons)-2 ( )]TJ 0 -1.38 Td [(f)-6.6 (or)5 ( t)-6.6 (hes)-1.9 (e)10.5 ( pr)-5.9 (oc)-2 (e)10.5 (dur)-6 (es)8.8 ( \()-5.9 (s)-2 (e)10.5 (e )]TJ /TT2 1 Tf 0.004 Tc 0.001 Tw [(P)8 (ri)8.7 (ma)16.5 (ry)4.1 ( T)17.2 (re)5.6 (a)5.6 (t)10.3 (me)5.7 (n)16.5 (t)]TJ /TT0 1 Tf 0 Tc 0 Tw 19.891 0 Td ( )Tj -0.005 Tc -0.001 Tw 0.283 0 Td [(in)-3.3 ( t)1.2 (h)-3.3 (e)-3.4 ( )-10.6 (NCCN )-10.6 (G)-9.6 (u)-3.3 (id)-3.4 (e)-3.3 (lin)-3.4 (e)-3.3 (s)-5.1 ( f)-20.5 (o)7.5 (r)-8.9 ( )]TJ 0 Tc 0 Tw -20.174 -1.37 Td (P)Tj -0.002 Tc 0.007 Tw 0.663 0 Td [(api)2.6 (l)2.6 (l)2.6 (ar)-16.8 (y)8.8 ( [)-6.6 (Thy)8.8 (r)-5.9 (oi)2.7 (d])-6.6 ( C)2.6 (ar)-6 (c)-2 (i)13.5 (nom)-6 (a and)10.5 ( )]TJ /TT2 1 Tf -0.005 Tc 0.005 Tw [(P)-1 (a)-3.4 (p)-3.3 (illa)-3.4 (r)-8.9 (y)-5 ( )]TJ -0.002 Tc 0.002 Tw 18.728 0 Td [(Thy)-2 (r)4.9 (oi)2.6 (d )]TJ 3.598 0 Td [(C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.005 Tc 0.01 Tw 5.109 0 Td [(in)7.5 ( t)-9.6 (h)-3.4 (is)5.9 ( )]TJ -0.002 Tc 0.007 Tw -28.098 -1.38 Td [(D)2.6 (i)2.6 (s)-2 (c)-2 (us)-2 (s)-2 (i)2.6 (on\))-6 (.)-6.6 ( )11.3 (I)-6.6 (n )11.3 (m)-6 (os)8.9 (t)-6.6 ( c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( s)-2 (et)4.2 (t)-6.6 (i)2.6 (ng)-11.2 (s)8.8 (,)-6.6 ( de)10.5 (c)-2 (i)2.6 (s)-2 (i)2.6 (ons)-2 ( ab)10.5 (out)-6.6 ( )11.3 (t)-6.6 (he ex)8.9 (t)-6.6 (ent)4.2 ( o)10.6 (f)-6.6 ( )]TJ 0 -1.37 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( s)-2 (houl)2.6 (d be)10.5 ( )11.2 (i)2.7 (ndi)-8.3 (v)8.9 (i)2.6 (dual)-8.3 (i)2.6 (z)8.9 (ed and done i)2.6 (n c)-2 (ons)-2 (ul)2.6 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (on w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (he )]TJ 0.002 Tw 0 -1.38 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 441.24 128.4 Tm (213)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 452.76 124.44 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(C)2.6 (i)2.6 (r)-5.9 (c)-2 (um)-5.9 (s)8.8 (t)-6.6 (anc)-2 (e)10.5 (s)-2 ( i)2.7 (n w)13.5 (hi)2.7 (c)-2 (h l)2.6 (obec)-2 (t)-6.6 (om)-5.9 (y)]TJ 0 Tc 0 Tw 15.283 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (s)-2 ( n)10.5 (ot)-6.6 ( )11.2 (r)-5.9 (ec)-2 (om)4.9 (m)-5.9 (ended)10.5 ( ar)-5.9 (e)10.5 ( )]TJ -0.005 Tc 0.01 Tw -20.174 -1.37 Td [(d)-3.3 (e)-3.4 (t)-9.6 (a)-3.4 (ile)-3.3 (d)-3.4 ( in)-3.3 ( t)-9.7 (h)-3.3 (e)7.5 ( NCCN )]TJ -0.002 Tc 0.007 Tw [(G)-6.6 (u)10.5 (i)2.6 (del)2.6 (i)2.6 (nes)-2 (.)-6.6 ( T)-10.5 (hi)2.6 (s)8.9 ( debat)-6.6 (e)10.5 ( r)-5.9 (e)10.5 (f)-17.5 (l)13.5 (ec)-2 (t)-6.6 (s)-2 ( )11.3 (t)-6.6 (he l)2.6 (i)2.6 (m)-5.9 (i)13.4 (t)-6.6 (at)-6.6 (i)2.6 (ons)-2 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.38 Td [(pr)-6 (o)10.5 (g)-11.2 (nos)-2 (t)-6.6 (i)2.6 (c)8.9 ( s)-2 (c)-2 (or)-5.9 (i)2.6 (n)10.5 (g)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 494.4 98.04 Tm (138)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 505.92 94.08 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(and t)-6.7 (he)10.5 ( m)-5.9 (o)10.5 (r)-6 (bi)2.6 (di)2.7 (t)-6.6 (y)8.8 ( o)10.5 (f)-17.4 (t)-6.7 (en)10.5 ( as)-2 (s)-2 (o)10.5 (c)-2 (i)2.6 (at)-6.6 (ed w)13.5 (i)2.6 (t)-6.7 (h t)-6.6 (ot)-6.7 (al)13.5 ( )]TJ -9.424 -1.37 Td [(t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( per)4.9 (f)-6.6 (or)5 (m)-6 (ed)10.5 ( out)-6.6 (s)-2 (i)2.6 (de o)10.5 (f)-6.6 ( )11.3 (m)]TJ 16.739 0 Td [(a)10.5 (j)-8.2 (or)4.9 ( c)-2 (anc)-2 (e)10.6 (r)-6 ( )11.3 (c)-2 (ent)-6.6 (er)-5.9 (s)8.8 (.)-6.6 ( P)2 (a)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( t)4.2 (r)-5.9 (eat)-6.6 (ed)10.6 ( )]TJ -16.739 -1.38 Td [(at)-6.6 ( )11.2 (t)-6.6 (he M)15.8 (ay)8.9 (o C)2.6 (l)2.6 (i)2.6 (n)-11.2 (i)2.6 (c)-2 ( C)2.6 (anc)-2 (er)-6 ( C)2.6 (ent)-6.6 (e)10.5 (r)-5.9 ( )11.2 (f)-6.6 (or)4.9 ( l)2.6 (ow)]TJ 0 Tc 0 Tw 17.88 0 Td (-)Tj 0.005 Tw 0.337 0 Td [(r)-4 (i)4.7 (sk P)14.9 (T)-8.6 (C)4.6 (s \()-3.9 (M)17.7 (A)4 (C)4.6 (I)-4.6 (S)4 ( sco)1.7 (r)-4 (e)12.6 ( )]TJ /C2_0 1 Tf 0 Tw <0094>Tj /TT0 1 Tf -0.002 Tc 0.002 Tw 11.641 0 Td [(3)10.5 (.)-6.6 (99\))4.9 ( )]TJ 0.007 Tw -29.859 -1.37 Td [(had no i)2.6 (m)-6 (p)10.5 (r)-5.9 (ov)8.9 (em)-6 (ent)4.3 ( i)2.6 (n s)8.9 (ur)-6 (v)8.9 (i)-8.3 (v)8.9 (al)2.6 ( r)-5.9 (at)-6.6 (es)-2 ( a)10.5 (f)-6.6 (t)-6.6 (e)10.5 (r)-5.9 ( und)10.5 (er)5 (goi)2.7 (ng)-11.2 ( p)10.5 (r)-5.9 (oc)-2 (edur)-6 (e)10.5 (s)-2 ( )11.3 (m)-5.9 (or)-6 (e)10.6 ( )]TJ EMC ET endstream endobj 742 0 obj 30563 endobj %% Contents for page 76 %% Original object ID: 153 0 743 0 obj << /Length 744 0 R >> stream Q q BT /Xi74 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 744 0 obj 245 endobj %% Contents for page 77 %% Original object ID: 154 0 745 0 obj << /Length 746 0 R >> stream q endstream endobj 746 0 obj 2 endobj %% Contents for page 77 %% Original object ID: 11409 0 747 0 obj << /Length 748 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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)11.3 (f)-17.5 (o)10.6 (r)-6 ( )]TJ 0 -1.37 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h A)2 (M)15.8 (E)1.9 (S)2 ( l)]TJ 0.009 Tc -0.009 Tw 9.13 0 Td (ow)Tj 0 Tc 0 Tw 1.272 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(r)-6 (i)2.7 (s)-2 (k)-12.9 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( )-10.6 (c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 260.28 324.72 Tm (215)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 271.8 320.76 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -22.772 -2.37 Td [(M)15.8 (os)-2 (t)-6.6 ( N)2.6 (C)2.6 (C)2.7 (N)2.6 ( P)1.9 (anel)2.6 ( )-10.5 (M)15.8 (em)-5.9 (ber)-6 (s)-2 ( )11.3 (r)-5.9 (ec)-2 (om)4.9 (m)-6 (end)10.6 ( t)-6.7 (o)10.6 (t)-6.6 (al)2.6 ( t)4.3 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (dec)-2 (t)-6.6 (om)-5.9 (y)8.8 ( )11.3 (f)-17.5 (or)4.9 ( pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 (s)-2 ( )]TJ 0 -1.38 Td [(w)2.6 (i)2.6 (t)-6.6 (h bi)2.6 (ops)-2 (y)]TJ 0 Tc 0 Tw 4.924 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(pr)-6 (ov)8.9 (en p)]TJ [(api)2.6 (l)2.6 (l)-8.3 (ar)-6 (y)8.9 ( c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( w)13.5 (ho hav)8.9 (e l)2.6 (ar)-6 (g)-11.2 (e)]TJ 0 Tc 0 Tw 18.946 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(v)8.9 (ol)2.6 (um)-6 (e pat)-6.6 (hol)2.6 (o)10.5 (g)-11.2 (i)2.6 (c)-2 ( )]TJ -0.004 Tw -24.543 -1.37 Td [(N)2.6 (1 )-10.6 (m)-6 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (as)-2 (e)10.6 (s)-2.1 ( \()]TJ 0 Tc 0 Tw 7.261 0 Td (>)Tj -0.002 Tc 0.007 Tw 0.587 0 Td [(5)10.5 ( i)2.6 (nv)8.9 (ol)-8.2 (v)8.8 (ed nodes)-2 ( w)13.5 (i)2.6 (t)-6.6 (h m)-6 (et)-6.7 (as)8.9 (t)-6.6 (as)8.9 (es)-2 ( >)-5 (2)10.5 ( m)4.9 (m)4.9 ( i)2.6 (n l)2.6 (ar)4.9 (g)-11.3 (es)8.9 (t)-6.6 ( )]TJ 0.002 Tw -7.848 -1.38 Td [(di)2.6 (m)-6 (ens)-2 (i)2.6 (on\))-5.9 (,)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 80.52 252.96 Tm [(3,)-1.9 (34,)-1.9 (21)-17 (6)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 107.52 249 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(bec)-2 (aus)-2 (e t)-6.7 (hi)2.6 (s)-2 ( p)10.5 (r)-5.9 (oc)-2 (edu)10.5 (r)-6 (e i)2.6 (s)-2 ( a)10.5 (s)-2 (s)-2 (oc)8.8 (i)2.6 (at)-6.6 (ed w)13.5 (i)2.6 (t)-6.6 (h i)2.6 (m)-5.9 (pr)-5.9 (ov)8.9 (ed )]TJ 0.002 Tw -7.891 -1.37 Td [(di)2.6 (s)-2 (eas)-2 (e)]TJ 0 Tc 0 Tw (-)Tj -0.011 Tc 0.016 Tw 3.761 0 Td [(f)-26.5 (r)-4.1 (e)-9.3 (e)-9.4 ( s)-11 (u)1.5 (r)-14.9 (vi)-6.3 (va)-20.2 (l)-6.4 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 127.44 237.84 Tm [(124)-16.9 (,)-1.9 (1)-16.9 (40,)-19.1 (215)-17 (,)-1.8 (2)-17 (17)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 179.88 233.88 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(S)2 (om)-5.9 (e c)-2 (ent)-6.6 (e)10.5 (r)-5.9 (s)8.8 ( r)-5.9 (e)10.5 (por)-5.9 (t)4.2 ( t)-6.6 (ha)10.5 (t)-6.6 ( pa)10.5 (t)-6.5 (i)2.6 (ent)-6.7 (s)8.9 ( t)4.3 (r)-6 (eat)-6.6 (ed)10.5 ( )]TJ -14.446 -1.38 Td [(by)8.8 ( l)2.6 (obec)-2 (t)-6.6 (om)-5.9 (y)8.9 ( al)2.6 (one hav)8.9 (e a 5)10.5 (%)-4.3 ( )11.2 (t)-6.6 (o 10)10.5 (%)-4.3 ( )11.3 (r)-5.9 (ec)-2 (ur)4.9 (r)-6 (enc)-2 (e)10.6 ( r)-5.9 (a)10.5 (t)-6.6 (e i)2.7 (n )11.3 (t)-6.6 (he oppo)10.6 (s)-2 (i)2.6 (t)-6.6 (e )]TJ 0 -1.37 Td [(t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d l)2.6 (obe.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 83.52 207.48 Tm [(132,)-1.8 (2)-17 (14)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 108.6 203.52 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 (f)-17.5 (t)-6.6 (e)10.5 (r)-5.9 ( l)13.5 (obec)-2 (t)-6.6 (om)-5.9 (y)8.8 (,)]TJ 0 Tc 0 Tw 7.207 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(t)-6.6 (hes)-2 (e)10.5 ( pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 (s)8.9 ( al)2.6 (s)-2 (o hav)8.9 (e an ov)8.8 (er)-6 (al)2.6 (l)2.6 ( )]TJ 0.002 Tw -15.478 -1.38 Td [(l)2.6 (ong)]TJ 0 Tc 0 Tw 1.891 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.326 0 Td [(t)-6.6 (er)5 (m)-6 ( r)-6 (ec)-2 (ur)4.9 (r)-5.9 (enc)-2 (e)10.5 ( )-10.6 (r)-6 (a)10.6 (t)4.2 (e )-10.6 (o)10.5 (f)-6.6 ( )-10.6 (m)-6 (o)10.6 (r)-6 (e t)-6.6 (han )-10.6 (30)10.5 (%)-4.3 ( \()-5.9 (v)8.8 (s)-2 (.)-6.6 ( 1%)-4.3 ( )-10.6 (a)10.5 (f)-6.6 (t)-6.6 (e)10.5 (r)-5.9 ( t)-6.6 (ot)-6.6 (al)2.7 ( )]TJ 0.007 Tw -2.217 -1.37 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( and )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 116.64 177.12 Tm (131)Tj -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 128.16 173.16 Tm [(I)-6.6 ( t)-6.6 (h)10.6 (er)-5.9 (apy)8.8 (\))]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 174.6 177.12 Tm (11)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 182.28 173.16 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(and t)-6.7 (he hi)13.5 (g)-11.2 (h)]TJ [(es)8.8 (t)-6.6 ( )11.3 (f)-6.6 (r)-6 (e)10.6 (q)-11.3 (uenc)-2 (y)8.9 ( \()-6 (11)10.5 (%)-4.3 (\))4.9 ( o)10.5 (f)-6.6 ( )]TJ -0.004 Tw -14.663 -1.38 Td [(s)-2 (ubs)-2 (eq)-11.2 (uen)10.5 (t)-6.6 ( pul)2.7 (m)-6 (onar)-6 (y)8.9 ( m)-5.9 (et)-6.6 (as)8.9 (t)-6.7 (as)-2 (es)8.8 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 197.28 161.88 Tm (218)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 208.8 157.92 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(H)2.6 (ow)13.4 (e)-11.2 (v)8.9 (er)-5.9 (,)-6.6 ( i)2.6 (n pr)-6 (ope)10.6 (r)-6 (l)2.6 (y)8.9 ( s)-2 (el)2.6 (ec)-2 (t)-6.6 (ed )]TJ -17.065 -1.37 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( )11.3 (t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (ed)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h l)2.6 (obec)-2 (t)-6.6 (om)-6 (y)8.9 ( al)2.6 (one,)4.3 ( r)-6 (ec)-2 (u)10.5 (r)-5.9 (r)-6 (en)10.5 (c)-2 (e )11.3 (r)-6 (at)-6.6 (es)8.9 ( m)-5.9 (ay)8.9 ( be)10.6 ( as)-2 ( l)2.6 (ow)13.5 ( as)-2 ( )]TJ 0.002 Tw 0 -1.38 Td [(4%)-4.4 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 42.6 131.52 Tm (41)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 50.28 127.56 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(H)2.6 (i)2.6 (g)-11.2 (he)10.6 (r)-6 ( )11.3 (r)-6 (ec)-2 (ur)5 (r)-6 (enc)-2 (e )11.2 (r)-5.9 (at)-6.6 (es)8.8 ( ar)-6 (e)10.6 ( al)2.6 (s)-2 (o obs)-2 (e)10.5 (r)-6 (v)8.9 (ed )11.3 (w)2.6 (i)2.6 (t)-6.6 (h )0.5 (c)-2.1 (er)-6 (v)8.9 (i)2.6 (c)-2 (al)2.6 ( l)2.6 (y)8.9 (m)-6 (ph node )]TJ -2.707 -1.37 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 ( and )11.3 (m)-5.9 (ul)2.6 (t)-6.6 (i)2.6 (c)-2 (en)10.5 (t)-6.6 (r)-6 (i)2.7 (c)-2 ( )11.2 (t)-6.6 (u)10.5 (m)-5.9 (or)-5.9 (s)8.8 (,)-6.6 ( p)10.6 (r)-6 (ov)8.9 (i)2.6 (di)2.6 (ng)-11.2 ( s)-2 (o)10.6 (m)-6 (e addi)2.6 (t)-6.6 (i)2.6 (onal)2.6 ( )11.3 (j)-8.3 (us)8.9 (t)-6.6 (i)13.5 (f)-17.5 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (o)10.5 (n )]TJ 0 -1.38 Td [(f)-6.6 (or)4.9 ( t)-6.6 (o)10.5 (t)-6.6 (al)2.6 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (dec)-2 (t)-6.6 (o)10.5 (m)-6 (y)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 134.88 101.16 Tm (11)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 142.56 97.2 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -11.065 -2.37 Td [(H)2.6 (ow)13.4 (e)-11.2 (v)8.9 (er)-5.9 (,)-6.6 ( s)-2 (om)-5.9 (e)10.5 ( pr)-5.9 (o)10.5 (m)-5.9 (i)2.6 (nent)-6.6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)5 ( s)-2 (pec)-2 (i)2.7 (al)2.6 (i)2.6 (s)-2 (t)-6.6 (s)-2 ( )11.3 (\()-6 (i)2.6 (nc)-2 (l)2.6 (udi)2.6 (ng s)-2 (om)-6 (e)10.6 ( at)4.3 ( )]TJ 0 -1.37 Td [(N)2.6 (C)2.6 (C)2.6 (N)2.6 ( )-10.4 (M)15.7 (em)-6 (ber)-5.9 ( )11.3 (I)-6.7 (ns)-2 (t)-6.6 (i)2.6 (t)-6.6 (u)10.5 (t)-6.6 (i)2.6 (o)10.5 (ns)-2 (\))-5.9 ( oppos)-2 (e)10.5 ( t)-6.6 (hi)2.6 (s)8.9 ( v)8.9 (i)2.6 (e)-11.2 (w)13.4 ( and adv)8.9 (oc)-2 (at)-6.6 (e uni)2.6 (l)2.7 (at)-6.6 (er)-5.9 (al)13.5 ( )]TJ 0 -1.38 Td [(l)2.6 (obec)-2 (t)-6.6 (om)-5.9 (y)8.8 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )11.3 (m)-6 (os)8.9 (t)-6.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( and )11.3 (f)]TJ -0.004 Tw 20.728 0 Td [(ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.7 (ar)-6 ( )-10.6 (c)-2 (ar)4.9 (c)-2 (i)2.6 (nom)-5.9 (a bas)-2 (ed )]TJ 0.007 Tw 13.826 42.87 Td [(on 1\))4.9 ( t)-6.6 (he)10.5 ( l)2.6 (ow)13.5 ( m)-6 (or)-6 (t)-6.6 (al)2.6 (i)2.6 (t)-6.6 (y)8.8 ( a)10.6 (m)-6 (on)10.5 (g)-11.2 ( )11.2 (m)-5.9 (os)8.9 (t)-6.6 ( pa)10.6 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( \()-5.9 (i)2.6 (e,)4.3 ( t)4.3 (hos)-2 (e pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( c)-2 (a)10.5 (t)-6.6 (e)10.5 (g)-11.2 (or)-6 (i)2.6 (z)8.9 (ed )]TJ 0 -1.38 Td [(as)-2 ( l)2.6 (ow)13.5 ( r)-6 (i)2.6 (s)-2 (k)-2 ( by)8.9 ( t)-6.6 (he )0.5 (A)1.9 (M)15.8 (E)1.9 (S)2 ( and ot)-6.6 (he)10.5 (r)-6 ( p)10.5 (r)-5.9 (o)10.5 (g)-11.2 (nos)-2 (t)-6.6 (i)2.6 (c)8.9 ( c)-2 (l)2.6 (a)10.5 (s)-2 (s)-2 (i)2.6 (f)-17.5 (i)2.6 (c)-2 (a)10.6 (t)-6.6 (i)2.6 (on s)-2 (c)-2 (he)10.6 (m)-6 (es)8.8 (\))-5.9 (;)4.2 ( an)10.5 (d )]TJ 0 -1.37 Td [(2\))-6 ( )11.3 (t)-6.7 (he hi)13.5 (g)-11.2 (h c)-2 (o)10.6 (m)-6 (pl)2.6 (i)2.7 (c)-2 (at)-6.6 (i)2.6 (on )11.3 (r)-6 (at)-6.6 (es)8.9 ( r)-6 (epo)10.5 (r)-6 (t)-6.6 (ed)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h m)-5.9 (or)-5.9 (e)10.5 ( )11.3 (ex)8.9 (t)-6.6 (ens)-2 (i)2.6 (v)8.8 (e )]TJ 0.002 Tw 0 -1.38 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 476.64 472.32 Tm [(137,)-1.8 (2)-17 (03,)-19.1 (21)-17 (9)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 515.4 468.36 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(The l)2.6 (ar)4.9 (g)-11.2 (e )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d r)-6 (e)10.5 (m)-5.9 (nant)4.3 ( )11.3 (r)-6 (em)-6 (ai)2.6 (ni)2.6 (ng a)10.6 (f)-6.7 (t)-6.6 (e)10.6 (r)-6 ( )]TJ -10.283 -1.37 Td [(uni)2.6 (l)2.6 (at)-6.6 (er)-5.9 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4.804 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up i)2.6 (s)-2 ( pl)2.6 (anned w)13.5 (i)2.6 (t)-6.6 (h s)-2 (er)-5.9 (um)4.9 ( )11.3 (Tg)-11.2 ( d)10.5 (et)-6.6 (e)10.5 (r)-6 (m)-5.9 (i)2.6 (nat)-6.6 (i)2.6 (ons)8.9 ( and w)13.5 (i)2.6 (t)-6.6 (h \()-6 (o)10.5 (r)-5.9 ( )]TJ EMC ET endstream endobj 748 0 obj 27443 endobj %% Contents for page 77 %% Original object ID: 155 0 749 0 obj << /Length 750 0 R >> stream Q q BT /Xi75 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 750 0 obj 245 endobj %% Contents for page 78 %% Original object ID: 156 0 751 0 obj << /Length 752 0 R >> stream q endstream endobj 752 0 obj 2 endobj %% Contents for page 78 %% Original object ID: 11410 0 753 0 obj << /Length 754 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 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a)10.5 (f)-6.6 (t)-6.6 (er)5 ( c)-2 (om)-6 (pl)2.6 (e)10.5 (t)-6.6 (i)2.6 (on t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (dec)-2 (t)-6.6 (o)10.5 (m)-6 (y)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 223.56 339.84 Tm (140)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 235.08 335.88 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)-6.6 (n an)10.5 (ot)-6.6 (her)4.9 ( s)-2 (t)-6.6 (udy)8.9 (,)4.2 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (ho )]TJ -19.446 -1.37 Td [(under)-5.9 (w)13.4 (ent)-6.6 ( c)-2 (om)-6 (pl)2.6 (et)-6.7 (i)2.7 (on)10.5 ( t)-6.6 (h)10.5 (y)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( w)13.5 (i)2.6 (t)-6.6 (hi)2.6 (n 6 m)-5.9 (o)10.5 (nt)-6.7 (hs)-2 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (hei)2.6 (r)4.9 ( pr)-5.9 (i)2.6 (m)-6 (a)10.6 (r)-6 (y)8.9 ( )]TJ 0 -1.38 Td [(oper)-6 (at)-6.6 (i)2.6 (on dev)8.8 (el)2.6 (oped s)-2 (i)13.5 (gni)2.6 (f)-17.5 (i)2.7 (c)-2 (an)10.5 (t)-6.6 (l)2.6 (y)8.9 ( f)-17.5 (ew)13.4 (er)-6 ( l)2.6 (y)8.9 (m)-5.9 (ph no)10.5 (de and he)10.5 (m)-6 (at)-6.6 (o)10.5 (g)-11.2 (enou)10.6 (s)-2 ( )]TJ 0 -1.37 Td [(r)-6 (ec)-2 (ur)5 (r)-6 (enc)-2 (es)8.8 (,)-6.6 ( and)10.6 ( t)-6.7 (hey)8.8 ( s)-2 (u)10.6 (r)-6 (v)8.9 (i)-8.3 (v)8.9 (ed s)-2 (i)2.6 (g)-11.2 (ni)13.5 (f)-17.5 (i)2.6 (c)-2 (ant)-6.6 (l)2.6 (y)8.9 ( l)2.6 (ong)-11.2 (e)10.5 (r)-5.9 ( )]TJ 22.38 0 Td [(t)-6.6 (han di)2.6 (d )11.2 (t)-6.6 (hos)-2 (e)10.6 ( i)2.6 (n w)13.5 (hom)-6 ( )]TJ -22.38 -1.38 Td [(t)-6.6 (he s)-2 (ec)-2 (ond)10.5 ( ope)10.5 (r)-6 (at)-6.6 (i)2.6 (on w)13.5 (as)-2 ( del)2.7 (ay)8.9 (ed )11.3 (f)-17.5 (or)5 ( m)-5.9 (o)10.5 (r)-5.9 (e )11.3 (t)-6.6 (han )11.3 (6 m)-5.9 (on)10.6 (t)-6.7 (hs)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 310.56 279.12 Tm (231)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 322.08 275.16 Tm ( )Tj 0.272 0 Td ( )Tj EMC /H3 <>BDC /TT2 1 Tf 0.016 Tc -0.005 Tw 9.96 -0 0 9.96 23.52 249.84 Tm [(S)8.3 (u)0.5 (r)7.4 (g)0.5 (i)4.9 (c)5.7 (a)5.8 (l)4.8 ( C)3.1 (o)0.5 (m)1.4 (p)0.5 (l)4.9 (i)4.8 (c)5.8 (a)5.7 (ti)4.9 (o)0.5 (n)0.5 (s)]TJ 0 Tc 0 Tw 11.386 0 Td ( )Tj 0.289 0 Td ( 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Tw 11.04 -0 0 11.04 235.08 204.24 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(Tr)-6 (an)10.5 (s)-2 (i)2.6 (ent)-6.6 ( c)-2 (l)2.7 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( )]TJ -19.446 -1.38 Td [(hy)8.8 (popar)-5.9 (at)-6.6 (hy)8.9 (r)-6 (oi)2.7 (di)2.6 (s)-2 (m)-5.9 ( a)10.5 (f)-6.6 (t)-6.6 (er)4.9 ( s)-2 (ur)4.9 (g)-11.2 (e)]TJ 13.739 0 Td [(r)-6 (y)8.9 ( i)2.6 (s)-2 ( c)-2 (o)10.6 (m)-6 (m)-6 (on)10.5 ( i)2.6 (n a)10.5 (dul)2.6 (t)-6.6 (s)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 284.64 192.96 Tm (234)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 296.16 189 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(and c)-2 (hi)2.6 (l)2.6 (dr)-6 (en)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 359.28 192.96 Tm [(140,)-19.1 (23)-17 (5)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 384.48 189 Tm ( )Tj -0.002 Tc -0.004 Tw -32.696 -1.37 Td [(under)4.9 (g)-11.2 (oi)2.6 (ng )-10.6 (t)-6.6 (o)10.5 (t)-6.6 (al)2.7 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 (.)4.3 ( T)-10.5 (he r)-5.9 (at)-6.6 (es)8.8 ( )-10.5 (o)10.5 (f)-6.6 ( )-10.6 (l)2.6 (on)10.5 (g)]TJ 0 Tc 0 Tw 21.663 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.326 0 Td [(t)-6.6 (er)5 (m)-6 ( r)-6 (ec)-2 (ur)4.9 (r)-5.9 (ent)4.2 ( )-10.6 (l)2.7 (ar)-6 (y)8.9 (ng)-11.2 (eal)2.6 ( )]TJ 0.007 Tw -21.989 -1.38 Td [(ner)-6 (v)8.9 (e i)2.6 (nj)-8.2 (ur)-5.9 (y)8.8 ( and hy)8.9 (popar)5 (at)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (di)2.6 (s)-2 (m)-6 (,)-6.6 ( )11.3 (r)-6 (es)-2 (pec)8.9 (t)-6.6 (i)2.6 (v)8.8 (el)-8.3 (y)-2 (,)-6.6 ( w)13.5 (er)-6 (e 3%)6.6 ( and )11.3 (2.)-6.6 (6)10.6 (%)-4.3 ( )]TJ 0 -1.37 Td [(a)10.5 (f)-17.5 (t)-6.6 (e)10.6 (r)-6 ( )11.3 (t)-6.6 (ot)-6.6 (al)2.6 ( )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (dec)-2 (t)-6.6 (o)10.5 (m)-6 (y)8.9 ( and 1.)-6.6 (9)10.5 (%)-4.3 ( and)]TJ 0 Tc 0 Tw 17.065 0 Td ( )Tj 0.005 Tc 0.283 0 Td [(0)6.7 (.2)17.5 (%)2.7 ( a)17.5 (fte)17.5 (r)11.9 ( s)5 (u)6.7 (b)6.7 (to)17.5 (ta)6.6 (l)9.7 ( )]TJ -0.002 Tc 0.002 Tw -17.348 -1.38 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 95.16 132.24 Tm (236)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 106.68 128.28 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(O)-6.6 (ne )11.3 (s)-2 (t)4.2 (udy)8.9 ( r)-6 (epor)-6 (t)-6.5 (ed)10.5 ( hy)8.8 (poc)-2.1 (al)2.6 (c)-2 (em)-6 (i)2.6 (a i)2.6 (n 5)10.6 (.)-6.7 (4%)6.6 ( o)10.5 (f)-6.6 ( pat)-6.6 (i)2.6 (ent)4.2 (s)-2 ( )]TJ -7.815 -1.37 Td [(i)2.6 (m)-5.9 (m)-6 (edi)2.6 (at)-6.6 (el)2.6 (y)8.9 ( a)10.5 (f)-6.6 (t)-6.6 (er)5 ( t)-6.6 (o)10.5 (t)-6.6 (al)2.6 ( t)-6.6 (h)10.5 (y)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 (,)-6.6 ( per)4.9 (s)-2 (i)2.6 (s)-2 (t)-6.6 (i)2.6 (n)10.5 (g)-11.2 ( i)13.5 (n onl)2.7 (y)8.8 ( 0.)-6.6 (5%)-4.3 ( o)10.5 (f)-6.6 ( )11.3 (pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( 1)10.5 ( )]TJ 0 -1.38 Td [(y)8.9 (ear)-6 ( l)2.6 (at)-6.6 (er)-5.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 72.6 101.88 Tm (237)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 84.12 97.92 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(A)2 (not)-6.7 (he)10.5 (r)]TJ 0 Tc 0 Tw 3.489 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(s)8.9 (t)-6.6 (u)10.5 (dy)8.9 ( r)-6 (epor)-5.9 (t)-6.6 (ed)10.5 ( a 3)10.5 (.)-6.6 (4%)6.6 ( i)2.6 (nc)-2 (i)2.6 (denc)-2 (e o)10.5 (f)-6.6 ( )]TJ 0.002 Tw [(l)2.6 (ong)]TJ 0 Tc 0 Tw (-)Tj -0.007 Tc 0.007 Tw 17.837 0 Td [(t)-0.7 (e)-5.4 (rm)-11 ( )]TJ -0.002 Tc -27.38 -1.37 Td [(r)-6 (ec)-2 (ur)5 (r)-6 (ent)4.3 ( l)2.6 (ar)-5.9 (y)8.8 (ng)-11.2 (eal)2.6 ( ne)10.5 (r)-6 (v)8.9 (e i)2.6 (nj)-8.3 (ur)-6 (y)]TJ 0 Tc 0 Tw 13.739 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(and)10.5 ( a 1)10.5 (.)-6.6 (1%)6.6 ( i)2.6 (nc)-2 (i)2.6 (denc)-2 (e o)10.5 (f)-6.6 ( per)4.9 (m)-5.9 (anen)10.6 (t)-6.6 ( )]TJ 0.002 Tw -14.022 -1.38 Td [(hy)8.8 (poc)-2 (al)2.6 (c)-2 (em)-5.9 (i)2.6 (a.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 93.84 71.52 Tm (238)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 105.36 67.56 Tm ( )Tj -0.002 Tc 0.007 Tw 0.261 0 Td [(W)-36.3 (hen )11.3 (ex)8.9 (per)-6 (i)2.7 (enc)-2 (ed s)-2 (ur)4.9 (g)-11.2 (eons)-2 ( p)10.5 (er)5 (f)-17.5 (o)10.5 (r)-6 (m)5 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (dec)-2 (t)-6.6 (o)10.5 (m)-5.9 (i)2.6 (es)-2 (,)4.3 ( )]TJ -7.674 -1.37 Td [(c)-2 (om)-6 (pl)2.7 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (ons)-2 ( oc)8.9 (c)-2 (ur)4.9 ( at)4.2 ( a )11.3 (l)2.6 (o)-11.3 (w)13.5 (er)-6 ( r)-5.9 (at)-6.6 (e)10.5 (.)4.3 ( A)2 ( s)8.8 (t)-6.6 (udy)8.9 ( o)10.5 (f)-17.5 ( 58)10.5 (60 pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( )11.3 (f)-6.7 (ound )11.2 (t)-6.6 (hat)4.3 ( )]TJ 34.554 41.804 Td [(s)-2 (ur)4.9 (g)-11.3 (eons)-2 ( w)13.5 (ho per)4.9 (f)-6.6 (or)4.9 (m)-6 (ed)10.5 ( m)-6 (o)10.6 (r)-6 (e )11.3 (t)-6.6 (han 100)10.5 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)8.9 (t)-6.6 (om)-5.9 (i)]TJ 23.935 0 Td [(es)8.8 ( a y)8.8 (ear)-5.9 ( had)10.5 ( t)-6.6 (he)10.6 ( )]TJ -23.935 -1.38 Td [(l)2.6 (o)-11.2 (w)13.5 (es)-2 (t)-6.6 ( ov)8.8 (er)-6 (al)2.6 (l)2.6 ( c)-2 (om)-6 (pl)2.6 (i)2.6 (c)-2 (at)-6.6 (i)13.5 (on r)-6 (a)10.6 (t)-6.6 (e )11.3 (\()-6 (4.)-6.6 (3)10.5 (%)-4.3 (\))4.9 (,)-6.6 ( w)13.5 (her)-6 (eas)-2 ( )11.3 (s)-2 (ur)4.9 (g)-11.2 (eons)-2 ( w)13.5 (ho per)4.9 (f)-6.6 (or)4.9 (m)-6 (ed)10.5 ( )]TJ 0 -1.37 Td [(f)-6.6 (ew)13.4 (er)-6 ( t)-6.6 (han 10)10.5 ( )11.3 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (dec)-1.9 (t)4.2 (om)-6 (i)2.6 (es)-2 ( a)10.5 ( y)8.8 (ear)-6 ( had 4)10.5 ( t)-6.6 (i)13.4 (m)-5.9 (e)10.5 (s)-2 ( as)-2 ( )11.2 (m)-5.9 (any)8.8 ( )]TJ 0.002 Tw 0 -1.38 Td [(c)-2 (om)-6 (pl)2.7 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (ons)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 474.84 472.32 Tm (239)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 486.36 468.36 Tm ( )Tj 0.283 0 Td ( )Tj EMC /H2 <>BDC /TT1 1 Tf 0.009 Tc -0.004 Tw -7.652 -2.391 Td [(R)2.7 (ad)0.5 (i)-6.5 (oa)10.7 (ct)5 (i)-6.5 (v)10.7 (e I)-6.5 (od)11.3 (i)-6.4 (ne)]TJ 0 Tc 0 Tw <97>Tj 0.009 Tc 0.007 Tw 9.989 0 Td [(D)13.6 (i)4.4 (agn)0.5 (os)10.7 (t)-5.9 (i)-6.5 (c)10.7 (s )0.5 (a)10.7 (nd )0.6 (T)11.3 (r)-4.2 (ea)10.7 (t)5 (m)-4.2 (e)10.7 (nt)]TJ 0 Tc 0 Tw 13 0 Td ( )Tj EMC /H3 <>BDC /TT2 1 Tf 0.016 Tc -0.005 Tw 9.96 -0 0 9.96 405 424.08 Tm [(D)3.1 (i)4.8 (a)5.8 (g)0.5 (n)0.5 (o)0.5 (s)5.7 (ti)4.9 (c)5.7 ( T)0.5 (o)12.6 (ta)5.7 (l)4.9 ( B)3.1 (o)0.5 (d)0.5 (y)5.8 ( I)4.8 (m)13.5 (a)5.7 (g)0.5 (i)4.9 (n)0.5 (g)0.5 ( a)5.8 (n)0.5 (d)0.5 ( T)0.5 (h)0.5 (y)5.7 (r)7.5 (o)0.5 (i)16.9 (d)0.5 ( S)8.3 (tu)0.5 (n)0.5 (n)12.6 (i)4.8 (n)0.5 (g)]TJ 0 Tc 0 Tw 25.88 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 408.72 Tm [(W)-25.4 (h)10.5 (e)10.6 (n i)2.6 (ndi)2.6 (c)-2 (at)-6.6 (ed)10.5 (,)-6.5 ( di)2.6 (a)10.5 (g)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (o)10.5 (t)-6.6 (al)2.7 ( body)8.9 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 590.4 412.68 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 601.92 408.72 Tm [(I)-6.6 ( i)2.6 (m)-6 (a)10.6 (g)-11.2 (i)2.6 (n)10.5 (g i)2.6 (s)-2 ( r)-5.9 (e)10.5 (c)-2 (om)4.9 (m)-6 (ended )]TJ -17.837 -1.38 Td [(\()-6 (c)-2 (at)-6.6 (e)10.5 (g)-11.2 (o)10.5 (r)-5.9 (y)8.8 ( 2B)1.9 (\))-5.9 ( a)10.5 (f)-6.6 (t)-6.6 (e)10.5 (r)-6 ( )11.3 (s)-2 (ur)4.9 (g)-11.2 (e)10.5 (r)-6 (y)8.9 ( t)-6.6 (o as)8.9 (s)-2 (es)-2 (s)-2 ( )11.3 (t)-6.6 (he)10.6 ( c)-2 (om)-5.9 (pl)2.6 (e)10.6 (t)4.2 (enes)-2 (s)-2 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (dec)-2 (t)-6.6 (om)-5.9 (y)8.8 ( )]TJ 0 -1.37 Td [(and t)-6.7 (o)10.6 ( as)]TJ 4.109 0 Td [(s)-2 (es)-2 (s)8.8 ( w)13.5 (het)-6.6 (her)-5.9 ( )11.2 (r)4.9 (es)-2 (i)2.6 (dual)2.6 ( di)2.6 (s)-2 (eas)-2 (e i)2.6 (s)-2 ( pr)-6 (e)10.5 (s)-2 (e)10.5 (nt)-6.6 ( )11.3 (\()-6 (s)-2 (ee )]TJ /TT3 1 Tf [(R)2.6 (A)2 (I)4.2 ( B)2 (ei)2.6 (ng )]TJ 0.002 Tw -4.109 -1.38 Td [(C)2.6 (ons)-2 (i)2.6 (der)-5.9 (ed )]TJ 0.007 Tw 5.38 0 Td [(B)2 (as)-2 (ed on)10.5 ( C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (opat)-6.6 (hol)2.7 (ogi)2.7 (c)-2 ( Feat)-6.6 (ur)-5.9 (e)10.5 (s)-2 ( )]TJ /TT0 1 Tf -0.005 Tc 0.01 Tw [(i)10.5 (n)-3.4 ( t)-9.6 (h)-3.4 (e)7.5 ( NCCN G)-9.6 (u)-3.4 (id)-3.3 (e)-3.3 (lin)-3.4 (e)-3.4 (s)-5 ( )]TJ -0.002 Tc 0.007 Tw -5.38 -1.37 Td [(f)-6.6 (or)4.9 ( P)1.9 (api)2.6 (l)2.6 (l)2.7 (ar)-5.9 (y)8.8 (,)-6.6 ( Fol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 (,)-6.6 ( and H)]TJ 0 Tc 0 Tw 13.022 0 Td Tj -0.002 Tc 0.007 Tw 0.554 0 Td [(r)-6 (t)-6.6 (hl)2.6 (e)10.5 ( C)2.6 (el)2.6 (l)2.6 ( C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a\))4.9 (.)-6.6 ( H)2.6 (ow)13.5 (ev)8.9 (er)-5.9 (,)-6.6 ( a )]TJ -0.004 Tw -13.576 -1.38 Td [(phenom)-6 (enon t)-6.6 (er)5 (m)-6 (ed)10.5 ( )-10.6 <93>]TJ 0.002 Tw 9.815 0 Td [(s)8.9 (t)4.2 (unni)2.6 (ng)]TJ 0.007 Tw 3.761 0 Td [<94>4.9 ( m)-5.9 (ay)8.9 ( oc)-2 (c)-2 (u)10.5 (r)-5.9 ( w)13.5 (hen i)2.6 (m)-5.9 (a)10.5 (g)-11.2 (i)2.6 (ng dos)-2 (es)8.8 ( o)10.5 (f)-6.5 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 731.04 336.72 Tm (13)Tj 0 Tc 0 Tw (1)Tj 0.005 Tc -0.005 Tw 11.04 -0 0 11.04 742.56 332.76 Tm (I )Tj -0.002 Tc -0.004 Tw -30.576 -1.37 Td [(i)2.6 (nduc)-2 (e f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.7 (ar)-6 ( )-10.6 (c)-2 (el)2.6 (l)2.6 ( )]TJ 0.002 Tw 8.924 0 Td [(dam)4.9 (ag)-11.2 (e)10.5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 546.36 321.6 Tm (240)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 557.88 317.64 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(S)2 (t)-6.7 (unni)2.6 (ng)]TJ 0 Tc 0 Tw 3.946 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(de)10.5 (c)-2 (r)-6 (eas)8.9 (es)-2.1 ( )-10.6 (upt)-6.6 (a)10.5 (k)-12.9 (e)10.5 ( )-10.6 (i)2.6 (n t)-6.6 (he t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0.004 Tc -0.01 Tw -18.359 -1.38 Td [(re)5.7 (mn)5.7 (a)5.6 (n)16.6 (t)-0.7 ( )-10.6 (o)16.6 (r me)]TJ -0.002 Tc 0.007 Tw 6.489 0 Td [(t)-6.6 (a)10.5 (s)-2 (t)-6.6 (as)-2 (es)8.9 (,)4.2 ( t)4.3 (hus)-2 ( i)2.6 (m)-5.9 (pai)2.6 (r)-6 (i)2.6 (n)10.6 (g)-11.3 ( )11.3 (t)-6.6 (he )11.3 (t)-6.6 (her)-6 (ap)10.5 (eut)-6.6 (i)2.6 (c)-2 ( e)10.5 (f)-6.6 (f)-6.6 (i)2.6 (c)-2 (ac)-2 (y)8.8 ( o)10.6 (f)-6.6 ( )]TJ 0.002 Tw -6.489 -1.37 Td [(s)-2 (ubs)-2 (eq)-11.2 (uen)10.6 (t)-6.6 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 465.12 291.24 Tm (131)Tj 0.005 Tc -0.005 Tw 11.04 -0 0 11.04 476.64 287.28 Tm (I.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 482.88 291.24 Tm (241)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 494.4 287.28 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -8.38 -2.37 Td [(T)-10.6 (o)10.6 ( av)8.9 (oi)2.6 (d 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2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 756 0 obj 245 endobj %% Contents for page 79 %% Original object ID: 158 0 757 0 obj << /Length 758 0 R >> stream q endstream endobj 758 0 obj 2 endobj %% Contents for page 79 %% Original object ID: 11411 0 759 0 obj << /Length 760 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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(ed l)2.6 (es)-2 (s)8.8 ( o)10.6 (f)-6.6 (t)-6.6 (en )11.2 (f)-6.6 (or)4.9 ( )]TJ -8.337 -1.38 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( a)10.5 (t)4.3 ( l)2.6 (ow)13.5 ( r)-5.9 (i)2.6 (s)-2 (k)-12.9 (.)4.3 ( )]TJ 0 Tc 0 Tw 8.75 0 Td ( )Tj EMC /H3 <>BDC /TT2 1 Tf 0.011 Tc 9.96 -0 0 9.96 23.52 473.4 Tm [(E)3.3 (lig)-4.5 (ib)-4.5 (ilit)-5.4 (y)0.7 ( f)-5.4 (o)-4.6 (r)2.5 ( )]TJ 0.01 Tc -0.01 Tw [(P)2.3 (o)-5.5 (st)-6.4 (o)-5.5 (p)-5.5 (er)1.4 (at)-6.4 (i)10.8 (ve )]TJ 0.016 Tc -0.005 Tw 13.578 0 Td [(R)3.1 (a)5.7 (d)0.5 (i)4.9 (o)0.5 (a)5.7 (c)5.7 (ti)4.9 (v)5.7 (e)5.8 ( I)4.9 (o)0.5 (d)0.5 (i)4.8 (n)0.5 (e)]TJ 0 Tc 0 Tw 9.06 0 Td ( )Tj 0.001 Tc -0.001 Tw 0.289 0 Td [(\()-15.4 (RA)-11.9 (I)-10.2 (\))]TJ 0 Tc 0 Tw 2.434 0 Td ( )Tj 0.301 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 458.04 Tm [(T)-10.6 (he)10.5 ( N)2.6 (C)2.6 (C)2.6 (N)2.6 ( P)2 (anel)2.6 ( r)-6 (ec)-2 (o)10.5 (m)4.9 (m)-6 (ends)-2 ( )]TJ [(a)10.5 ( s)-2 (el)2.6 (ec)-2 (t)-6.6 (i)2.6 (v)8.9 (e 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(l)2.7 (anc)-2 (e )11.3 (f)-17.5 (or)4.9 ( r)-6 (ec)-2 (u)10.5 (r)-6 (r)5 (ent)-6.7 ( )0.5 (di)2.6 (s)-2 (eas)-2 (e)10.5 ( \()-5.9 (s)-2 (ee)10.6 ( bel)2.6 (ow)13.5 (\))-5.9 (;)-6.7 ( )]TJ 0 -1.38 Td [(2\))-6 ( ad)10.5 (j)-8.3 (uv)8.8 (ant)-6.6 ( t)-6.6 (h)10.5 (er)-6 (apy)8.9 ( t)-6.6 (o)10.5 ( t)4.3 (r)-6 (y)8.9 ( t)-6.6 (o)10.5 ( el)2.6 (i)2.6 (m)]TJ 14.239 0 Td [(i)2.6 (nat)-6.6 (e s)-2 (u)10.5 (s)-2 (pec)-2 (t)-6.6 (ed)10.6 ( )11.2 (m)-5.9 (i)2.6 (c)-2 (r)-6 (o)10.6 (m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.8 (;)-6.6 ( o)10.5 (r)-5.9 ( 3)10.5 (\))-6 ( )]TJ -14.239 -1.37 Td [(R)2.6 (A)2 (I)-6.6 ( t)-6.7 (he)10.5 (r)-5.9 (apy)8.9 ( t)-6.6 (o)10.5 ( t)4.3 (r)-5.9 (eat)4.2 ( )11.3 (k)-12.9 (no)10.5 (w)13.5 (n per)-5.9 (s)-2 (i)2.6 (s)-2 (t)-6.6 (ent)-6.6 ( di)2.6 (s)-2 (eas)-2 (e)10.6 (.)4.2 ( )11.3 (The N)2.6 (C)2.6 (C)2.6 (N)2.6 ( )0.5 (G)-6.7 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )]TJ 0 -1.38 Td [(hav)8.9 (e 3 di)2.6 (f)-6.6 (f)-6.6 (er)-6 (e)10.5 (nt)4.3 ( pat)-6.7 (hw)13.5 (ay)-2 (s)-2 ( )11.3 (f)-17.5 (o)10.6 (r)-6 ( pos)8.9 (t)-6.6 (oper)-5.9 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e R)2.6 (A)2 (I)-6.6 ( a)10.5 (dm)-5.9 (i)2.6 (ni)2.7 (s)-2 (t)-6.6 (r)-6 (a)10.5 (t)-6.6 (i)2.6 (on bas)-2 (ed)10.5 ( on )]TJ 0 -1.37 Td [(c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (opat)-6.6 (hol)2.7 (og)-11.2 (i)2.6 (c)-2 ( )11.3 (f)-17.5 (a)10.5 (c)-2 (t)-6.6 (o)10.5 (r)-5.9 (s)-2 (:)4.2 ( 1\))4.9 ( R)2.6 (A)2 (I)-6.6 ( )11.2 (t)-6.6 (y)8.9 (pi)2.6 (c)-1.9 (al)2.6 (l)-8.2 (y)8.8 ( r)-5.9 (ec)-2 (om)4.9 (m)4.9 (ended;)-6.6 ( 2)10.5 (\))-6 ( R)2.6 (A)2 (I)4.2 ( s)-2 (el)2.6 (ec)-2 (t)-6.6 (i)2.6 (v)8.8 (el)2.6 (y)-2 ( )]TJ 0.004 Tc -0.004 Tw 0 -1.38 Td (re)Tj -0.002 Tc 0.007 Tw 0.891 0 Td [(c)-2 (om)4.9 (m)-6 (ended)10.6 (;)-6.7 ( and)10.6 ( 3\))4.9 ( R)2.6 (A)2 (I)-6.6 ( not)4.3 ( )11.2 (t)-6.6 (y)8.9 (pi)2.6 (c)-2 (al)2.6 (l)-8.2 (y)8.8 ( r)-5.9 (ec)-2 (om)-6 (m)-5.9 (e)10.5 (nded )]TJ -0.013 Tc 0.013 Tw [(\()-17 (s)-13 (e)-11.3 (e )]TJ /TT3 1 Tf -0.005 Tc 0.005 Tw -0.891 -1.37 Td (Clin)Tj 0 Tc 0 Tw 1.707 0 Td (i)Tj 0.217 0 Td (co)Tj 1.054 0 Td (p)Tj -0.002 Tc 0.007 Tw 0.554 0 Td [(at)-6.7 (hol)2.7 (ogi)2.6 (c)-2 ( Fac)-2 (t)-6.6 (or)4.9 (s)]TJ 0 Tc 0 Tw 7.598 0 Td ( )Tj /TT0 1 Tf -0.005 Tc 0.01 Tw 0.283 0 Td [(in)-3.3 ( t)-9.6 (h)-3.3 (e)7.5 ( NCCN )]TJ -0.002 Tc -0.004 Tw [(G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( f)-17.5 (o)10.6 (r)]TJ 0 Tc 0 Tw 12.022 0 Td ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(P)-1 (a)-3.4 (p)-3.4 (illa)-3.4 (r)-9 (y)5.9 (,)-9.6 ( F)-2.7 (o)-3.4 (llic)-5 (u)-3.3 (la)-3.4 (r)-8.9 (,)-9.7 ( )]TJ -0.002 Tc 0.007 Tw -23.717 -1.38 Td (and H)Tj 0 Tc 0 Tw 2.663 0 Td Tj -0.005 Tc 0.01 Tw 0.554 0 Td [(r)-9 (t)-9.6 (h)-3.3 (le)7.5 ( Ce)-3.4 (ll Ca)-3.3 (r)-9 (c)-5 (in)-3.4 (o)-3.3 (m)-9 (a)-3.3 (\))1.9 (.)]TJ 0 Tc 0 Tw 9.63 0 Td ( )Tj EMC /P <>BDC -12.848 -2.37 Td (P)Tj -0.002 Tc 0.002 Tw 0.663 0 Td [(os)-2 (t)-6.7 (oper)-5.9 (a)10.5 (t)-6.6 (i)2.6 (v)8.8 (e )]TJ -0.005 Tc 0.005 Tw 5.707 0 Td [(RA)-1 (I)]TJ 0 Tc 0 Tw 1.663 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (s)-2 ( )11.3 (t)-6.6 (y)8.8 (pi)-8.3 (c)-2 (al)2.6 (l)2.6 (y)8.9 ( r)-6 (ec)-2 (om)-5.9 (m)-6 (ended)10.6 ( )11.2 (f)-17.5 (o)10.6 (r)-6 ( p)10.5 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( a)10.5 (t)4.3 ( hi)2.6 (g)-11.2 (h)10.5 ( r)-5.9 (i)2.6 (s)8.8 (k)-2 ( o)10.6 (f)-6.6 ( )]TJ -8.315 -1.38 Td [(hav)8.9 (i)2.6 (ng)-11.2 ( per)-5.9 (s)-2 (i)2.6 (s)-2 (t)-6.6 (en)10.6 (t)-6.7 ( di)2.6 (s)-2 (eas)8.9 (e r)-5.9 (e)10.5 (m)-6 (ai)2.6 (ni)2.6 (ng a)10.5 (f)-6.6 (t)-6.6 (er)4.9 ( t)-6.6 (o)10.6 (t)-6.7 (al)2.6 ( t)-6.6 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( and i)2.6 (nc)-2 (l)2.6 (udes)-2 ( )]TJ 0 -1.37 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h any)8.9 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.5 ( )11.3 (f)-6.7 (ol)2.6 (l)2.6 (o)-11.2 (w)13.5 (i)2.6 (ng)-11.3 ( )11.3 (f)-17.5 (ac)8.8 (t)-6.6 (or)-6 (s)8.9 (:)-6.6 ( 1)10.5 (\))-5.9 ( )11.2 (gr)-6 (os)-2 (s)8.8 ( ex)8.9 (t)-6.6 (r)-6 (at)-6.7 (hy)8.9 (r)-6 (oi)2.6 (dal)2.6 ( ex)8.9 (t)-6.6 (ens)-2 (i)2.6 (on;)4.3 ( )]TJ 0 -1.37 Td [(2\))-6 ( a)10.5 ( pr)-6 (i)2.6 (m)-5.9 (a)10.5 (r)-6 (y)8.9 ( t)-6.6 (u)10.5 (m)-5.9 (or)4.9 ( )11.3 (g)-11.2 (r)-6 (ea)10.5 (t)4.3 (er)-6 ( )11.3 (t)-6.6 (han 4)10.5 ( c)-2 (m)4.9 (;)4.3 ( or)4.9 ( 3\))4.9 ( pos)-2 (t)]TJ -0.004 Tw 21 0 Td [(o)10.5 (per)-5.9 (at)-6.6 (i)2.6 (v)8.9 (e )-10.6 (uns)-2 (t)-6.6 (i)2.5 (m)-5.9 (ul)2.7 (a)10.5 (t)-6.6 (ed Tg )]TJ 0.007 Tw -21 -1.38 Td [(g)-11.2 (r)4.9 (eat)-6.6 (e)10.5 (r)-5.9 ( )11.2 (t)-6.6 (han 5)10.5 ( t)-6.6 (o)10.5 ( 10 n)10.5 (g/)4.2 (m)-5.9 (L.)4.2 ( I)-6.6 (n)10.5 ( t)-6.6 (he)10.5 ( c)-2 (as)-2 (e)10.6 ( o)10.5 (f)-6.6 ( )11.2 (f)-17.4 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( o)10.5 (r)-5.9 ( )]TJ 0 Tc 0 Tw (H)Tj 24.38 0 Td Tj -0.007 Tc 0.007 Tw 0.554 0 Td [(rt)-11.6 (h)-5.3 (l)-2.5 (e)]TJ 0 Tc 0 Tw 1.935 0 Td ( )Tj -0.005 Tc 0.005 Tw 0.283 0 Td [(c)-5 (e)-3.4 (ll )]TJ -0.002 Tc 0.007 Tw -27.152 -1.37 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (,)-6.6 ( ex)8.9 (t)-6.6 (ens)-2 (i)2.6 (v)8.9 (e v)8.9 (as)-2 (c)-1.9 (ul)2.6 (ar)-6 ( i)2.6 (nv)8.8 (as)-2 (i)2.6 (on i)2.6 (s)-2 ( anot)-6.6 (he)10.5 (r)-5.9 ( i)2.6 (ndi)2.6 (c)-2 (at)-6.6 (i)2.6 (on )11.2 (f)-6.6 (or)4.9 ( )]TJ 0 -1.38 Td [(pos)-2 (t)-6.6 (oper)-6 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e )0.5 (R)2.5 (A)2 (I)-6.6 (.)-6.6 ( P)]TJ 0.002 Tw 9.152 0 Td [(os)8.8 (t)-6.6 (o)10.5 (per)-5.9 (at)-6.6 (i)2.7 (v)8.8 (e )]TJ -0.005 Tc 0.005 Tw 5.696 0 Td [(RA)-1 (I)]TJ 0 Tc 0 Tw 1.663 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(i)2.6 (s)-2 ( )-10.6 (al)2.6 (s)-2 (o)10.5 ( f)-6.6 (r)-5.9 (e)10.5 (quent)-6.6 (l)2.6 (y)8.9 ( )-10.6 (r)-6 (ec)-2 (om)5 (m)-6 (ended f)-6.6 (or)4.9 ( )]TJ -16.793 -1.37 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( )-10.6 (w)13.5 (i)2.6 (t)-6.6 (h k)-12.9 (now)13.5 (n/)-6.6 (s)-2 (us)]TJ 0.007 Tw 10.533 0 Td [(p)10.5 (ec)-2 (t)-6.6 (ed di)2.6 (s)8.9 (t)-6.6 (ant)4.3 ( m)-6 (e)10.5 (t)-6.6 (as)8.8 (t)-6.6 (as)-2 (es)8.9 ( at)4.2 ( pr)-6 (es)-2 (en)10.5 (t)-6.6 (at)-6.6 (i)2.6 (on)10.6 ( )]TJ -0.013 Tc 0.013 Tw [(\()-17 (s)-13 (e)-11.3 (e )]TJ /TT3 1 Tf -0.005 Tc 0.005 Tw -10.533 -1.38 Td (Clin)Tj 0 Tc 0 Tw 1.707 0 Td (i)Tj 0.217 0 Td (co)Tj 1.054 0 Td (p)Tj -0.002 Tc 0.007 Tw 0.554 0 Td [(at)-6.7 (hol)2.7 (ogi)2.6 (c)-2 ( Fac)-2 (t)-6.6 (or)4.9 (s)]TJ /TT0 1 Tf 0 Tc 0 Tw 7.598 0 Td ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(in)-3.3 ( t)-9.6 (h)-3.3 (e)7.5 ( NCCN )]TJ -0.002 Tc -0.004 Tw [(G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2.1 ( f)-17.5 (o)10.6 (r)]TJ 0 Tc 0 Tw 12.022 0 Td ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(P)-1 (a)-3.4 (p)-3.3 (illa)-3.4 (r)-9 (y)5.9 (,)-9.6 ( F)-2.7 (o)-3.4 (llic)-5 (u)-3.3 (la)-3.4 (r)-8.9 (,)-9.6 ( )]TJ -0.002 Tc 0.007 Tw -23.717 -1.37 Td (and H)Tj 0 Tc 0 Tw 2.663 0 Td Tj -0.005 Tc 0.01 Tw 0.554 0 Td [(r)-9 (t)-9.6 (h)-3.3 (le)7.5 ( Ce)-3.4 (ll Ca)-3.3 (r)-9 (c)-5 (in)-3.3 (o)-3.4 (m)-9 (a)-3.3 (\))1.9 (.)]TJ 0 Tc 0 Tw 9.641 0 Td ( )Tj 0.272 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -13.13 -2.38 Td [(P)2 (os)-2 (t)-6.6 (oper)-6 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e R)2.6 (A)1.9 (I)-6.6 ( i)2.6 (s)-2 ( )]TJ 0.002 Tw [(s)-2 (el)13.5 (ec)-2 (t)-6.6 (i)2.6 (v)8.9 (el)-8.2 (y)]TJ 0 Tc 0 Tw 13.891 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(r)-6 (ec)-2 (om)5 (m)-6 (ended f)-6.7 (o)10.6 (r)-6 ( )-10.6 (pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( )]TJ -0.016 Tc 0.016 Tw 11.87 0 Td [(wh)-14.4 (o)]TJ 0 Tc 0 Tw 1.815 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(ar)-6 (e)10.5 ( at)4.2 ( )]TJ -0.004 Tw -28.141 -1.37 Td [(g)-11.2 (r)4.9 (eat)-6.6 (e)10.5 (r)-5.9 ( r)-5.9 (i)2.6 (s)-2 (k)-2 ( f)-6.7 (or)4.9 ( )-10.6 (r)-5.9 (ec)-2 (u)10.5 (r)-5.9 (r)-6 (enc)8.9 (e )]TJ -0.016 Tc 0.021 Tw 11.75 0 Td [(wi)-11.4 (t)-20.6 (h)-14.4 ( a)]TJ -0.002 Tc 0.007 Tw 2.598 0 Td [(ny)8.8 ( of)-6.6 ( t)-6.6 (he)10.5 ( )11.3 (f)-17.5 (ol)2.6 (l)2.6 (ow)13.5 (i)2.6 (n)-11.2 (g)]TJ 0 Tc 0 Tw ( )Tj -0.005 Tc 0.01 Tw 8.261 0 Td [(c)-5 (lin)-3.3 (ic)-5 (a)-3.4 (l in)-3.4 (d)-3.3 (ic)-5 (a)-3.4 (t)-9.6 (io)-3.3 (n)-3.4 (s)-5 ( )]TJ -0.002 Tc 0.007 Tw -22.609 -1.38 Td [(s)-2 (uc)-2 (h as)8.8 ( l)2.6 (ar)4.9 (g)-11.2 (es)-2 (t)4.3 ( pr)-6 (i)13.5 (m)-6 (ar)-6 (y)8.9 ( t)4.3 (um)-6 (or)4.9 ( 2 )11.2 (t)-6.6 (o 4)10.5 ( c)8.9 (m)-6 (,)]TJ 0 Tc 0 Tw 17.783 0 Td ( )Tj -0.005 Tc 0.005 Tw 0.283 0 Td [(h)-3.3 (ig)-14.3 (h)]TJ 0 Tc 0 Tw 1.88 0 Td (-)Tj -0.011 Tc 0.011 Tw 0.337 0 Td [(r)-15 (i)-6.3 (sk)]TJ 0 Tc 0 Tw 1.543 0 Td ( )Tj -0.005 Tc 0.005 Tw 0.283 0 Td [(h)-3.3 (is)-5 (t)-9.7 (o)-3.3 (lo)7.5 (g)-14.2 (y)]TJ 0 Tc 0 Tw 3.924 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(\()4.9 (f)-17.5 (o)10.6 (r)-6 ( papi)2.7 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( )]TJ 0.002 Tw -26.315 -1.37 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (\))]TJ -0.006 Tc 0.006 Tw 4.935 0 Td (, )Tj -0.002 Tc 0.007 Tw 0.554 0 Td [(l)2.6 (y)8.9 (m)-6 (phat)-6.6 (i)2.6 (c)-2 ( or)5 ( v)8.8 (as)-2 (c)-2 (ul)2.6 (ar)-6 ( )]TJ [(i)2.7 (nv)8.9 (as)-2 (i)2.6 (on,)-6.6 ( c)-2 (er)-6 (v)8.9 (i)2.6 (c)-2 (al)2.6 ( l)2.6 (y)8.8 (m)-5.9 (ph node )]TJ 0.002 Tw -5.489 -1.38 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)]TJ 0.007 Tw 5.098 0 Td [(,)-6.6 ( )11.3 (m)-6 (ac)8.8 (r)-5.9 (os)-2 (c)-2 (opi)13.5 (c)-2 ( m)-5.9 (ul)13.5 (t)-6.6 (i)13.5 (f)-17.5 (oc)-2 (al)2.6 (i)2.6 (t)-6.6 (y)8.9 ( \()-6 (one )11.2 (f)-6.6 (oc)-2 (us)8.9 ( >)-5 (1)10.6 ( c)-2 (m)4.9 (\))-6 (,)4.3 ( uns)8.9 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (at)-6.6 (ed)10.5 ( )]TJ 0.002 Tw -5.098 -1.37 Td [(pos)-2 (t)-6.6 (o)]TJ 0.007 Tw [(per)-6 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e )0.5 (s)-2 (er)-6 (um)4.9 ( )11.3 (Tg \()5 (<)-5 (5)]TJ 0 Tc 0 Tw <96>Tj -0.002 Tc 0.007 Tw 12.772 0 Td [(10 n)10.5 (g/)-6.6 (m)-6 (L)10.5 (\))-5.9 (,)4.2 ( or)4.9 ( m)-5.9 (i)2.6 (c)8.8 (r)-5.9 (os)8.9 (c)-2 (opi)2.6 (c)-2 ( pos)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (e )]TJ 0.002 Tw 21.783 42.804 Td [(m)-6 (ar)4.9 (g)-11.2 (i)2.6 (ns)]TJ 0 Tc 0 Tw 3.554 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 447.36 517.92 Tm [(3,)-1.9 (249,)-1.9 (2)-17 (50)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 478.2 513.96 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(H)2.6 (o)-11.2 (w)13.5 (e)-11.2 (v)8.8 (er)-6 (,)-6.6 ( )11.3 (t)-6.6 (he N)2.6 (C)2.6 (C)2.6 (N)2.6 ( P)2 (anel)2.6 ( does)8.9 ( )11.2 (not)-6.6 ( )11.3 (r)-6 (out)-6.6 (i)2.6 (nel)2.6 (y)8.8 ( r)-5.9 (ec)-2 (om)4.9 (m)-6 (end)10.6 ( )]TJ -6.913 -1.38 Td [(R)2.6 (A)2 (I)-6.6 ( )11.2 (f)-17.5 (o)10.6 (r)-6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (i)2.7 (t)-6.7 (h al)2.6 (l)2.7 ( of)-6.6 ( )11.3 (t)-6.6 (he )11.2 (f)-6.6 (ol)2.6 (l)2.6 (ow)2.6 (i)2.6 (ng)-11.2 ( )11.3 (f)-6.6 (ac)-2 (t)-6.6 (o)10.5 (r)-5.9 (s)-2 (:)4.3 ( 1\))4.9 ( )11.3 (ei)2.6 (t)-6.6 (her)-5.9 ( uni)13.5 (f)-17.5 (o)10.5 (c)-2 (al)2.6 ( \()4.9 (<)-5 (2 c)8.8 (m)5 (\))-6 ( )]TJ -0.004 Tw 0 -1.37 Td [(or)-6 ( m)-6 (ul)2.6 (t)-6.6 (i)13.4 (f)-17.4 (oc)-2 (al)2.6 ( c)-2 (l)2.6 (as)-2 (s)-2 (i)2.6 (c)-2 ( )-10.6 (papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( )-10.6 (m)-6 (i)2.6 (c)-2 (r)-5.9 (oc)-2 (ar)4.9 (c)-2 (i)2.6 (nom)-5.9 (as)8.9 ( )-10.6 (\()-6 (al)2.6 (l)2.6 ( f)-17.5 (oc)-2 (i)2.6 ( )]TJ /C2_0 1 Tf 0 Tc 0 Tw <0094>Tj /TT0 1 Tf -0.002 Tc -0.004 Tw 24.707 0 Td [(1)10.5 ( )-10.6 (c)-2 (m)4.9 (\))-5.9 ( c)-2 (on)10.5 (f)-17.5 (i)2.7 (ned t)-6.6 (o )]TJ 0.007 Tw -24.707 -1.38 Td [(t)-6.6 (he )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d;)-6.6 ( 2\))4.9 ( no)10.6 ( det)-6.6 (ec)8.9 (t)-6.6 (a)10.5 (bl)2.6 (e ant)-6.6 (i)]TJ 0 Tc 0 Tw 14.239 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(Tg)-11.2 ( an)10.6 (t)-6.7 (i)2.7 (bodi)2.6 (es)-2 (;)4.2 ( a)10.6 (nd 3\))4.9 ( pos)-2 (t)-6.6 (ope)10.6 (r)-6 (at)-6.7 (i)2.7 (v)8.8 (e )]TJ -14.565 -1.37 Td [(uns)-2 (t)-6.6 (i)2.6 (m)-5.9 (ul)2.6 (at)-6.6 (ed)10.5 ( )11.3 (Tg)-11.2 ( l)2.6 (es)-2 (s)8.8 ( t)-6.6 (ha)10.5 (n 1 n)]TJ -0.004 Tw 13.022 0 Td [(g/)-6.6 (m)-6 (L)10.5 (.)-6.6 ( G)-6.6 (ui)2.6 (del)2.7 (i)2.6 (nes)-2 ( f)-6.6 (r)4.9 (om)-6 ( t)-6.6 (he )-10.6 (A)12.8 (T)-10.6 (A)12.9 ( )-10.6 (l)2.6 (i)2.6 (s)-2 (t)-6.6 ( )-10.6 (v)8.9 (er)-5.9 (y)8.8 ( )]TJ 0.007 Tw -13.022 -1.38 Td [(s)-2 (i)2.6 (m)-5.9 (i)2.6 (l)2.6 (ar)-5.9 ( i)2.6 (ndi)2.6 (c)-2 (at)-6.6 (i)2.7 (ons)-2 ( )11.2 (f)-6.6 (or)4.9 ( po)10.6 (s)-2 (t)-6.7 (oper)-5.9 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e R)2.6 (A)2 (I)-6.6 ( us)-2 (e)10.5 ( and )11.3 (al)2.6 (s)-2 (o pr)-5.9 (ov)8.9 (i)2.6 (de s)-2 (pec)-2 (i)13.5 (f)-17.5 (i)2.6 (c)-2 ( )]TJ 0 -1.37 Td [(g)-11.2 (ui)2.6 (danc)-2 (e )11.2 (r)-5.9 (e)10.5 (g)-11.2 (ar)-5.9 (di)2.6 (n)10.6 (g t)-6.6 (he)10.5 ( s)8.9 (a)10.5 (f)-17.5 (e us)-2 (e)10.5 ( o)10.5 (f)-6.6 ( R)2.6 (A)2 (I)4.3 ( i)2.6 (n t)-6.6 (he)10.5 ( out)4.3 (pat)-6.6 (i)2.6 (ent)-6.6 ( s)-2.1 (e)10.6 (t)4.2 (t)-6.6 (i)2.6 (ng)]TJ 0 Tc 0 Tw (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 715.8 426.84 Tm [(3,)-1.9 (251)]TJ /TT1 1 Tf 0 Tc 0 Tw 11.04 -0 0 11.04 733.08 422.88 Tm ( )Tj /TT0 1 Tf 0.293 0 Td ( )Tj EMC /H3 <>BDC /TT2 1 Tf 0.016 Tc -0.005 Tw 9.96 -0 0 9.96 405 397.44 Tm [(P)8.3 (o)0.5 (s)5.8 (to)0.5 (p)0.5 (e)5.7 (r)7.4 (a)5.8 (ti)4.8 (v)5.8 (e)5.7 ( A)3.1 (d)0.5 (m)1.4 (i)4.9 (n)0.5 (i)4.8 (s)5.7 (tr)19.4 (a)5.8 (ti)4.8 (o)0.5 (n)0.5 ( o)0.5 (f R)3.1 (A)3.1 (I)4.8 ( )]TJ 0 Tc 0 Tw 17.88 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 405 382.2 Tm [(S)2 (t)-6.7 (udi)2.7 (es)-2 ( )]TJ 3.609 0 Td [(s)-2 (how)13.5 ( )]TJ 0.007 Tw 2.598 0 Td [(dec)-2 (r)-6 (eas)-2 (ed)10.5 ( r)-5.9 (ec)-2 (u)10.5 (r)-5.9 (r)-6 (enc)-2.1 (e)10.6 ( and di)2.6 (s)-2 (eas)-2 (e)]TJ 0 Tc 0 Tw 15.348 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.326 0 Td [(s)-2 (pec)-2 (i)13.5 (f)-17.5 (i)2.6 (c)-2 ( )-10.6 (m)-5.9 (o)10.5 (r)-6 (t)4.3 (al)2.7 (i)2.6 (t)-6.6 (y)8.8 ( f)-17.5 (or)4.9 ( )]TJ 0.002 Tw -21.88 -1.38 Td [(popul)2.6 (at)-6.6 (i)2.6 (ons)]TJ 0 Tc 0 Tw 5.098 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(at)4.2 ( i)2.6 (nt)-6.6 (er)4.9 (m)-5.9 (edi)13.5 (at)-6.6 (e o)10.5 (r)-6 ( )]TJ 0.002 Tw [(hi)13.4 (g)-11.2 (her)]TJ 0 Tc 0 Tw 10.793 0 Td ( )Tj -0.011 Tc 0.011 Tw 0.283 0 Td [(r)-15 (i)-6.3 (sk)-11 ( )]TJ -0.002 Tc 0.007 Tw 1.826 0 Td [(w)13.5 (hen pos)-1.9 (t)-6.7 (oper)-6 (a)10.6 (t)-6.6 (i)2.6 (v)8.8 (e )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 705.24 370.92 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 716.76 366.96 Tm [(I)-6.6 ( t)-6.6 (her)-6 (apy)8.9 ( )]TJ -28.239 -1.37 Td [(i)2.6 (s)-2 ( adm)-5.9 (i)2.6 (ni)2.6 (s)-2 (t)-6.6 (er)-6 (ed)10.5 ( as)8.9 ( par)4.9 (t)-6.6 ( o)10.6 (f)-6.7 ( )11.3 (t)-6.6 (he i)2.6 (ni)2.6 (t)-6.6 (i)2.6 (al)2.6 ( t)4.3 (r)-6 (eat)4.3 (m)-5.9 (en)10.5 (t)-6.6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 627.12 355.8 Tm [(11,)-1.8 (13)-17 (1,)-1.9 (1)-16.9 (39,)-19.1 (25)-17 (2)]TJ 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 7.293 0 Td [(2)-17 (54)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 689.52 351.84 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)-6.6 (n a s)8.8 (t)-6.5 (udy)8.8 ( )]TJ -26.054 -1.38 Td [(as)-2 (s)-2 (es)-2 (s)-2 (i)2.6 (ng out)4.3 (c)-2 (om)-5.9 (es)8.9 ( i)2.6 (n 1)10.5 (004 pat)-6.7 (i)2.7 (ent)-6.7 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h )0.5 (di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (a,)4.3 ( )]TJ 0 -1.37 Td [(t)-6.6 (um)-5.9 (o)10.5 (r)-5.9 ( )11.2 (r)-5.9 (ec)-2 (ur)4.9 (r)-6 (enc)-2 (e)10.6 ( w)13.4 (as)-2 ( about)-6.6 ( 3)]TJ 0 Tc 0 Tw 13.239 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(f)-17.5 (ol)2.6 (d hi)13.5 (g)-11.3 (her)5 ( i)2.6 (n pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( ei)2.7 (t)-6.7 (he)10.5 (r)-5.9 ( )11.2 (t)-6.6 (r)-5.9 (ea)10.6 (t)-6.7 (ed)10.5 ( )]TJ -0.016 Tc 0.016 Tw [(wi)-11.4 (t)-20.6 (h)-14.4 ( )]TJ -0.002 Tc 0.007 Tw -13.565 -1.38 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d hor)4.9 (m)-6 (one al)2.6 (one o)10.5 (r)4.9 ( )11.3 (g)-11.2 (i)2.6 (v)8.9 (en no pos)-2 (t)-6.6 (ope)10.5 (r)-5.9 (at)-6.6 (i)2.6 (v)8.9 (e )11.3 (m)-5.9 (edi)2.6 (c)-2 (al)2.6 ( t)-6.6 (he)10.5 (r)-6 (apy)8.9 ( w)13.5 (hen )]TJ 0 -1.37 Td [(c)-2 (om)-6 (par)-5.9 (ed)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h pat)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( )11.3 (w)13.5 (ho under)-6 (w)13.5 (ent)-6.6 ( pos)-2 (t)-6.6 (oper)4.9 (at)-6.6 (i)2.6 (v)8.9 (e t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d r)-5.9 (em)-5.9 (nan)10.5 (t)-6.6 ( )]TJ 0 -1.38 Td [(abl)2.6 (at)-6.6 (i)2.6 (on w)13.5 (i)2.6 (t)-6.6 (h )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 469.2 279.84 Tm (131)Tj 0.005 Tc 0 Tw 11.04 -0 0 11.04 480.72 275.88 Tm (I \()Tj /TT3 1 Tf -0.004 Tc 0.004 Tw 0.902 0 Td (P )Tj /TT0 1 Tf -0.002 Tc 0.007 Tw 0.946 0 Td [(<)-5 ( )11.3 (.)-6.6 (00)10.5 (1\))-5.9 (.)4.2 ( M)15.8 (or)-6 (eov)8.9 (er)-6 (,)-6.6 ( )11.3 (f)-17.5 (ew)13.5 (er)-6 ( pat)-6.6 (i)2.6 (e)10.5 (nt)-6.6 (s)-2 ( dev)8.9 (el)2.6 (oped di)2.6 (s)-2 (t)-6.6 (an)10.6 (t)-6.6 ( )]TJ -8.707 -1.37 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 ( \()]TJ /TT3 1 Tf -0.015 Tc 0.015 Tw 5.717 0 Td (P )Tj /TT0 1 Tf -0.002 Tc 0.007 Tw 0.935 0 Td [(<)5.9 ( .)-6.6 (002)10.5 (\))-5.9 ( a)10.5 (f)4.3 (t)-6.6 (er)4.9 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d r)-6 (e)10.6 (m)-6 (na)]TJ -0.013 Tc 0.013 Tw [(nt)-17.6 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 620.64 264.72 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 632.16 260.76 Tm [(I)-6.6 ( a)10.5 (bl)2.6 (at)-6.6 (i)2.6 (on t)-6.6 (han )11.3 (a)10.5 (f)-6.6 (t)-6.6 (er)4.9 ( ot)-6.6 (he)10.5 (r)-5.9 ( )]TJ -20.576 -1.38 Td [(f)-6.6 (or)4.9 (m)-6 (s)-2 ( o)10.5 (f)-6.6 ( po)10.5 (s)-2 (t)-6.6 (ope)10.5 (r)-5.9 (at)-6.6 (i)2.6 (v)8.9 (e t)4.3 (r)4.9 (eat)-6.6 (m)-5.9 (en)10.5 (t)-6.6 (.)4.3 ( H)2.6 (ow)13.5 (ev)8.8 (er)-6 (,)-6.6 ( t)-6.6 (hi)2.6 (s)-2 ( e)10.5 (f)-6.6 (f)-6.6 (ec)8.9 (t)-6.6 ( i)2.6 (s)8.9 ( obs)-2 (er)-5.9 (v)8.9 (ed onl)2.6 (y)8.8 ( i)2.7 (n )]TJ 0 -1.37 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h pr)-6 (i)13.5 (m)-5.9 (ar)-5.9 (y)8.8 ( t)-6.6 (u)10.6 (m)4.9 (or)-6 (s)-2 ( )0.5 (1)10.5 (.)-6.6 (5 c)8.9 (m)4.9 ( or)5 ( m)-6 (o)10.5 (r)-5.9 (e i)2.6 (n di)2.6 (a)10.6 (m)-6 (et)-6.7 (e)10.6 (r)-6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 680.28 234.36 Tm (252)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 691.8 230.4 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 (not)-6.7 (her)4.9 ( s)8.8 (t)-6.6 (udy)8.9 ( )]TJ -26.261 -1.38 Td [(o)10.5 (f)-17.5 ( 21)10.5 (,)-6.6 (870 i)2.6 (nt)-6.6 (e)10.5 (r)5 (m)-6 (edi)2.6 (at)-6.6 (e )11.3 (r)-6 (i)2.6 (s)-2 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0 -1.37 Td [(c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.7 ( f)-17.4 (ac)8.9 (t)-6.6 (or)-5.9 (s)8.9 ( \()-6 (H)2.6 (R)2.6 (,)4.3 ( 0)10.5 (.)-6.6 (71;)4.3 ( 95%)6.5 ( C)2.6 (I)-6.6 (,)4.3 ( 0)10.5 (.)-6.6 (62)]TJ 0 Tc 0 Tw <96>Tj -0.002 Tc 0.002 Tw 17.674 0 Td [(0.)-6.7 (82)10.5 (;)-6.6 ( )]TJ /TT3 1 Tf 0 Tc 0 Tw 2.5 0 Td (P)Tj 0.652 0 Td ( )Tj /TT0 1 Tf -0.002 Tc -0.004 Tw 0.283 0 Td [(<)5.9 ( .)-6.6 (001\))4.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 675.6 173.64 Tm (254)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 687.12 169.68 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(S)2 (om)-5.9 (e s)8.9 (t)-6.6 (udi)2.6 (es)-1.9 ( )]TJ -25.837 -1.38 Td [(hav)8.9 (e f)-17.5 (ound)10.5 ( t)-6.6 (ha)10.5 (t)-6.6 ( )11.2 (r)-5.9 (e)10.5 (m)-5.9 (nant)4.3 ( )11.2 (abl)2.6 (at)-6.6 (i)2.6 (on had l)2.6 (es)-2 (s)-2 ( o)10.6 (f)-6.7 ( )11.3 (a )11.3 (t)-6.7 (he)10.5 (r)-5.9 (apeut)-6.6 (i)2.6 (c)-2 ( e)10.5 (f)-6.6 (f)-6.6 (e)10.5 (c)-2 (t)4.3 (,)-6.6 ( pe)10.5 (r)-5.9 (haps)-2 ( )]TJ 0 -1.37 Td [(bec)-2 (aus)-2 (e )11.2 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0.552 0 Td (56)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 458.28 52.44 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(H)2.6 (ow)13.4 (e)-11.2 (v)8.9 (er)-5.9 (,)-6.6 ( a)10.5 ( )]TJ 5.304 0 Td [(m)-6 (or)-6 (e)10.6 ( r)-6 (ec)-2.1 (en)10.5 (t)]TJ 0 Tc 0 Tw 5.326 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(s)-2 (t)-6.6 (udy)8.9 ( r)-6 (epo)10.5 (r)-5.9 (t)4.2 (ed t)-6.6 (ha)10.5 (t)-6.6 ( )11.3 (t)-6.6 (he i)2.6 (nc)-2 (i)2.6 (denc)-2 (e o)10.5 (f)-6.6 ( )]TJ EMC ET endstream endobj 760 0 obj 28663 endobj %% Contents for page 79 %% Original object ID: 159 0 761 0 obj << /Length 762 0 R >> stream Q q BT /Xi77 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 762 0 obj 245 endobj %% Contents for page 80 %% Original object ID: 160 0 763 0 obj << /Length 764 0 R >> stream q endstream endobj 764 0 obj 2 endobj %% Contents for page 80 %% Original object ID: 11412 0 765 0 obj << /Length 766 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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(Tg pr)-6 (o)10.6 (duc)-2 (t)-6.6 (i)2.6 (on,)4.2 ( )11.3 (w)13.5 (h)-11.2 (i)2.6 (c)-2 (h )11.3 (f)-17.5 (ac)-2 (i)2.6 (l)2.6 (i)2.6 (t)-6.6 (at)-6.6 (es)8.9 ( i)2.6 (dent)-6.6 (i)13.5 (f)-17.5 (i)2.6 (c)8.9 (at)-6.7 (i)2.7 (on o)10.5 (f)-6.6 ( pat)-6.6 (i)2.6 (en)10.6 (t)-6.7 (s)-1.9 ( w)13.4 (ho ar)-6 (e)10.6 ( )]TJ 0 -1.38 Td [(f)-6.6 (r)-6 (ee)10.5 ( o)10.5 (f)-6.6 ( di)2.6 (s)-2 (eas)-2 (e and)10.6 ( m)-6 (ay)8.8 ( )11.3 (s)-2 (i)2.6 (m)-5.9 (pl)2.6 (i)2.6 (f)-17.5 (y)8.9 ( t)-6.6 (hei)13.5 (r)-6 ( c)-2 (a)10.6 (r)]TJ 18.12 0 Td [(e w)13.5 (hi)2.6 (l)2.6 (e pr)-5.9 (om)-6 (o)10.6 (t)-6.6 (i)2.6 (ng ear)-6 (l)2.6 (y)8.9 ( )]TJ -18.12 -1.37 Td [(i)2.6 (dent)-6.6 (i)2.6 (f)-17.5 (i)2.6 (c)-2 (a)10.5 (t)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (hos)-2 (e w)13.4 (i)2.6 (t)-6.6 (h r)-6 (es)-2 (i)2.6 (dual)2.6 ( c)-2 (anc)-2 (e)10.5 (r)-6 (;)4.3 ( and)10.5 ( 3\))4.9 ( el)2.6 (i)2.7 (m)-6 (i)2.6 (nat)-6.6 (i)2.6 (on o)10.5 (f)-6.5 ( nor)5 (m)-6 (al)2.6 ( )]TJ 0 -1.38 Td [(t)-6.6 (i)2.6 (s)-2 (s)-2 (ue,)4.3 ( w)13.4 (hi)2.6 (c)-2 (h m)-6 (ay)8.8 ( el)2.6 (i)2.6 (m)-6 (i)2.7 (nat)-6.7 (e )11.3 (t)-6.6 (he ni)2.6 (dus)8.9 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( c)-2.1 (on)10.5 (t)-6.6 (i)2.6 (nued c)-2 (on)10.5 (f)-17.5 (oundi)2.6 (n)10.5 (g ant)-6.6 (i)]TJ 0 Tc 0 Tw 30.087 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.326 0 Td (Tg )Tj 0.007 Tw -30.413 -1.37 Td [(ant)-6.6 (i)2.6 (body)8.8 ( pr)-6 (oduc)-2 (t)-6.6 (i)2.6 (on.)4.3 ( C)2.6 (on)10.5 (v)8.9 (er)-6 (s)-2 (el)2.6 (y)8.8 (,)-6.6 ( ot)-6.6 (her)-6 (s)-2 ( a)10.5 (r)5 (g)-11.2 (ue )11.3 (t)-6.6 (ha)10.5 (t)-6.6 ( )11.3 (m)-6 (os)-2 (t)4.3 ( r)-5.9 (e)10.5 (c)-2 (ur)4.9 (r)-5.9 (enc)-2 (es)-2 ( )11.3 (c)-2 (an )]TJ 0 -1.38 Td [(be eas)-2 (i)2.6 (l)2.6 (y)8.9 ( det)]TJ 5.598 0 Td [(ec)-2 (t)-6.7 (ed)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h )0.5 (nec)-2 (k)-2 ( )0.5 (ul)2.6 (t)4.3 (r)-6 (as)-2 (ound and)10.5 ( t)-6.6 (ha)10.5 (t)-6.6 ( )11.2 (s)-2 (er)-6 (um)4.9 ( )11.3 (Tg)-11.2 ( l)2.6 (ev)8.9 (el)2.7 (s)-2 ( ar)-5.9 (e)10.5 ( o)10.5 (f)-6.6 (t)-6.6 (e)10.5 (n )]TJ -5.598 -1.37 Td [(q)-11.2 (ui)2.6 (t)-6.6 (e)10.6 ( l)2.7 (ow)13.5 ( af)-6.6 (t)-6.6 (er)4.9 ( a )11.3 (t)-6.6 (ot)-6.6 (al)13.5 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 (.)4.2 ( )11.3 (T)-10.6 (her)-5.9 (e)10.5 (f)-6.6 (or)-6 (e)10.5 (,)-6.6 ( i)2.6 (n)10.5 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( a)10.5 (t)-6.6 ( l)2.6 (ow)13.5 ( and )]TJ 0 -1.38 Td [(i)2.6 (nt)-6.6 (er)-5.9 (m)-6 (edi)2.6 (a)10.5 (t)-6.6 (e )11.3 (r)-6 (i)2.6 (s)-2 (k)-2 (,)4.3 ( t)-6.6 (he)10.5 ( c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( bene)10.6 (f)-17.5 (i)2.6 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (r)-6 (out)-6.6 (i)2.6 (ne)10.5 ( r)-6 (e)10.5 (m)-5.9 (nant)4.3 ( abl)2.6 (at)-6.6 (i)2.6 (on as)8.9 ( a )]TJ -0.004 Tw 0 -1.37 Td [(r)-6 (e)10.6 (q)-11.3 (ui)2.6 (r)-5.9 (em)-6 (en)10.5 (t)-6.6 ( f)-6.6 (or)5 ( )-10.7 (opt)-6.6 (i)13.5 (m)-5.9 (al)2.6 ( f)-6.6 (ol)2.6 (l)2.7 (o)-11.3 (w)]TJ 0 Tc 0 Tw 13.065 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up r)-5.9 (em)-5.9 (ai)2.6 (ns)8.8 ( unc)-2 (er)4.9 (t)]TJ 0.002 Tw 7.978 0 Td [(ai)2.6 (n.)-6.6 ( )]TJ 0 Tc 0 Tw 1.88 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -23.261 -2.37 Td [(D)2.6 (at)-6.6 (a s)-2 (u)10.5 (gg)-11.2 (es)8.9 (t)-6.6 ( )11.3 (t)-6.7 (hat)4.2 ( l)2.6 (ow)13.5 (er)-6 ( dos)-2 (es)-2 ( o)10.5 (f)-6.6 ( R)2.6 (A)2 (I)4.2 ( ar)-6 (e)10.6 ( as)-2 ( e)10.5 (f)4.3 (f)-6.6 (e)10.5 (c)-2 (t)-6.6 (i)2.6 (v)8.9 (e as)-2 ( hi)2.6 (g)-11.2 (he)10.5 (r)-5.9 ( do)10.5 (s)-2 (es)]TJ 0 Tc 0 Tw 30.804 0 Td <97>Tj -0.013 Tc 0.013 Tw [(30)-11.3 ( )]TJ -0.002 Tc -0.004 Tw -30.804 -1.38 Td [(v)8.9 (er)-5.9 (s)-2 (us)-2 ( )-10.6 (100 m)-6 (C)2.6 (i)]TJ 0 Tc 0 Tw 6.924 0 Td <97>Tj -0.002 Tc 0.007 Tw 0.989 0 Td [(f)-17.5 (o)10.5 (r)-5.9 ( abl)13.5 (at)-6.6 (i)2.6 (on i)2.6 (n pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 (s)-2 ( w)13.4 (i)2.6 (t)-6.6 (h l)2.6 (ow)]TJ 0 Tc 0 Tw 13.576 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(r)-6 (i)2.7 (s)8.8 (k)-12.8 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )-10.6 (c)-2 (anc)-2 (e)10.5 (r)-5.9 ( \()-5.9 (e)10.5 (g)-11.2 (,)4.2 ( )]TJ -21.826 -1.37 Td [(T)-10.6 (1b)10.5 (/)4.3 (T)-10.6 (2 [)-6.6 (1)]TJ 0 Tc 0 Tw <96>Tj -0.002 Tc 0.007 Tw 4.826 0 Td [(4 c)8.9 (m)4.9 (])-6.6 (,)4.3 ( c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( N)2.6 (0 di)2.6 (s)-2 (eas)-2 (e\))-6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 207.72 188.16 Tm [(32,)-1.8 (33)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 225 184.2 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (he N)2.7 (C)13.4 (C)2.6 (N)2.7 ( G)-6.7 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( r)-5.9 (e)10.5 (f)-17.5 (l)2.6 (ec)8.8 (t)-6.5 ( a)10.5 ( )]TJ 0.004 Tc 0.001 Tw -18.533 -1.38 Td [(mo)5.7 (re)16.6 ( c)]TJ -0.002 Tc 0.007 Tw 3.054 0 Td [(aut)-6.6 (i)2.6 (ous)8.9 ( appr)-5.9 (oac)-2 (h)10.5 ( )11.3 (t)-6.6 (o us)-2 (i)2.6 (n)10.5 (g)-11.2 ( R)2.6 (A)12.8 (I)-6.6 ( abl)2.6 (at)-6.6 (i)2.6 (on)10.6 ( bas)8.8 (ed on )11.3 (t)-6.6 (hes)-2 (e )11.2 (r)-5.9 (ando)10.6 (m)-6 (i)2.6 (z)8.9 (ed )]TJ -0.005 Tc 0.005 Tw -3.054 -1.37 Td [(t)-9.6 (r)-9 (ia)-3.3 (ls)-5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 49.92 157.8 Tm (261)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 61.44 153.84 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)4.3 (f)-6.7 ( )0.5 (R)2.6 (A)1.9 (I)-6.6 ( a)10.5 (bl)2.6 (at)-6.6 (i)2.7 (on i)2.7 (s)8.8 ( us)-2 (ed,)4.3 ( t)-6.6 (he)10.5 ( N)2.6 (C)2.6 (C)2.6 (N)2.6 ( G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( r)-5.9 (ec)-2 (o)10.6 (m)4.9 (m)-6 (end )]TJ -0.013 Tc 0.018 Tw -3.717 -1.38 Td [(\()-17 (c)-13 (a)-11.3 (t)-17.6 (eg)-22.2 (or)-16.9 (y)-2.2 ( 1)-11.3 (\))-17 ( 3)-11.3 (0 )11.3 (m)-17 (C)-8.4 (i)-8.4 ( of)-17.6 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 135.48 142.56 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 147 138.6 Tm [(I)-6.6 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( R)2.7 (A)1.9 (I)4.3 ( abl)2.6 (at)-6.6 (i)2.6 (on i)2.7 (n pa)10.6 (t)-6.6 (i)13.5 (ent)-6.7 (s)-2 ( )0.5 (a)10.5 (t)-6.6 ( l)]TJ 13.859 0 Td [(ow)13.4 ( r)-5.9 (i)2.6 (s)8.9 (k)-12.9 ( bas)-2 (ed)10.6 ( on)10.5 ( )]TJ -0.004 Tw -25.043 -1.37 Td [(t)-6.6 (hes)-2 (e r)-5.9 (andom)-6 (i)2.6 (z)8.9 (ed )-10.6 (t)4.3 (r)-6 (i)2.6 (al)2.6 (s)-2 (.)-6.6 ( T)-10.5 (hi)2.6 (s)-2 ( s)-2 (am)-6 (e)10.5 ( )-10.6 (abl)2.6 (at)-6.6 (i)2.6 (on )-10.6 (dos)-2 (e)]TJ 0 Tc 0 Tw 21.663 0 Td <97>Tj -0.002 Tc -0.004 Tw [(30 m)-6 (C)2.6 (i)]TJ 0 Tc 0 Tw 4.152 0 Td <97>Tj -0.002 Tc 0.007 Tw [(m)-6 (ay)8.9 ( be )]TJ -25.815 -1.38 Td [(c)-2 (ons)-2 (i)2.6 (der)-5.9 (ed )11.3 (\()-6 (c)-2 (at)-6.6 (e)10.6 (g)-11.3 (o)10.6 (r)-6 (y)8.9 ( 2B)2 (\))-6 ( i)2.6 (n pa)10.6 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( at)4.2 ( )0.5 (s)-2 (l)2.6 (i)2.6 (g)-11.3 (h)10.6 (t)-6.6 (l)2.6 (y)8.8 ( hi)2.6 (g)-11.2 (he)10.6 (r)-6 ( )11.3 (r)-6 (i)2.6 (s)-2 (k)-2 ( \()4.9 (s)-2 (ee )]TJ /TT2 1 Tf [(R)2.7 (A)1.9 (I)4.3 ( B)1.9 (ei)2.6 (ng )]TJ 0.002 Tw 0 -1.37 Td [(C)2.6 (ons)-2 (i)2.6 (der)-5.9 (ed )]TJ 0.007 Tw 5.38 0 Td [(B)2 (as)-2 (ed on)10.5 ( C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (opat)-6.6 (hol)2.6 (ogi)2.7 (c)-2 ( Feat)-6.6 (ur)-5.9 (e)10.5 (s)-2 ( )]TJ /TT0 1 Tf -0.005 Tc 0.01 Tw [(i)10.5 (n)-3.4 ( t)-9.6 (h)-3.4 (e)7.5 ( NCCN G)-9.6 (u)-3.4 (id)-3.3 (e)-3.3 (lin)-3.4 (e)-3.4 (s)-5 ( )]TJ -0.002 Tc 0.007 Tw -5.38 -1.38 Td [(f)-6.6 (or)4.9 ( P)1.9 (api)2.6 (l)2.6 (l)2.7 (ar)-5.9 (y)8.8 (,)-6.6 ( Fol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 (,)-6.6 ( and)]TJ 0 Tc 0 Tw ( )Tj 12.304 0 Td (H)Tj 0.717 0 Td Tj -0.005 Tc 0.01 Tw 0.554 0 Td [(r)-9 (t)-9.6 (h)-3.3 (le)7.5 ( Ce)-3.4 (ll Ca)-3.3 (r)-9 (c)-5 (in)-3.4 (o)-3.3 (m)-9 (a)-3.3 (\))1.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 279.84 81.84 Tm (262)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 291.36 77.88 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(R)2.6 (A)2 (I)-6.6 ( abl)2.6 (at)-6.6 (i)2.6 (on i)2.6 (s)-2 ( n)10.6 (ot)-6.6 ( )]TJ -24.543 -1.37 Td [(r)-6 (ec)-2 (om)5 (m)-6 (ended)10.5 ( i)2.7 (n pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( at)4.3 ( v)8.9 (er)-5.9 (y)8.8 ( l)2.6 (ow)13.5 ( r)-6 (i)2.6 (s)-2 (k)-12.9 (.)4.3 ( )]TJ 0 Tc 0 Tw 18.609 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw 15.946 40.87 Td [(R)2.6 (A)2 (I)-6.6 ( t)-6.7 (he)10.5 (r)-5.9 (apy)8.9 ( )11.2 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Tw 11.04 -0 0 11.04 702.72 483.6 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (he po)10.5 (s)-2 (s)-2 (i)2.6 (bl)2.6 (e )]TJ -27.25 -1.38 Td [(bene)10.5 (f)-17.5 (i)2.6 (t)-6.6 (s)-2 ( o)10.5 (f)-6.6 ( R)2.6 (A)12.9 (I)-6.7 ( s)-2 (houl)2.6 (d)10.5 ( b)10.5 (e w)13.5 (ei)2.6 (g)-11.2 (hed w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (he )11.3 (r)-6 (i)2.6 (s)8.9 (k)-12.9 ( o)10.6 (f)-6.7 ( adv)8.8 (er)-6 (s)-2 (e e)10.5 (f)4.3 (f)-6.7 (ec)-2 (t)-6.6 (s)8.9 ( as)8.9 ( par)4.9 (t)-6.6 ( )]TJ -0.013 Tc 0 -1.37 Td [(of)-28.5 ( t)-17.6 (r)-17 (e)-11.3 (at)-17.6 (m)-17 (e)-11.3 (nt)-17.6 ( )-10.6 (d)-11.4 (ec)-13 (i)-8.4 (s)-13 (i)-8.4 (o)-11.4 (n)]TJ 0 Tc 0 Tw 9.25 0 Td (-)Tj -0.013 Tc 0.013 Tw 0.337 0 Td [(m)-17 (ak)-23.9 (i)-8.4 (ng)-22.2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 549.48 457.2 Tm (261)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 561 453.24 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 (dv)8.9 (er)-5.9 (s)-2 (e e)10.6 (f)-6.7 (f)-6.6 (ec)8.9 (t)-6.6 (s)-2.1 ( )11.3 (m)-5.9 (ay)8.9 ( be )11.3 (m)-6 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(m)-5.9 (onar)-5.9 (y)8.8 ( m)-5.9 (e)10.5 (t)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 ( t)-6.6 (ha)10.6 (t)-6.6 ( )11.2 (c)-2 (onc)-2 (ent)-6.6 (r)-5.9 (a)10.5 (t)-6.6 (e 5)10.6 (0%)6.6 ( or)4.9 ( )]TJ EMC ET endstream endobj 766 0 obj 28363 endobj %% Contents for page 80 %% Original object ID: 161 0 767 0 obj << /Length 768 0 R >> stream Q q BT /Xi78 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 768 0 obj 245 endobj %% Contents for page 81 %% Original object ID: 162 0 769 0 obj << /Length 770 0 R >> stream q endstream endobj 770 0 obj 2 endobj %% Contents for page 81 %% Original object ID: 11413 0 771 0 obj << /Length 772 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 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-14.674 -1.38 Td [(wit)-9.6 (h)-3.4 ( 1)-3.3 (5)-3.4 (0)-3.3 ( )11.2 (m)-8.9 (Ci o)7.6 (f)-9.6 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 102.48 502.68 Tm (131)Tj 0.005 Tc 0 Tw 11.04 -0 0 11.04 114 498.72 Tm (I \()Tj -0.002 Tc 0.007 Tw 0.902 0 Td [(555)10.5 (0 M)15.8 (B)1.9 (q)-11.2 (\))-6 ( o)10.6 (r)-6 ( l)2.6 (es)-2 (s)8.8 ( t)-6.6 (o)10.6 ( av)8.9 (oi)2.6 (d l)2.6 (ung i)2.7 (nj)-8.3 (ur)-5.9 (y)8.8 (,)4.3 ( w)13.5 (hi)2.6 (c)-2 (h m)-6 (ay)8.8 ( )]TJ -9.098 -1.37 Td [(oc)-2 (c)-2 (ur)-5.9 ( w)13.4 (h)]TJ [(en m)-6 (o)10.6 (r)-6 (e )11.3 (t)-6.6 (han)10.5 ( 8)10.6 (0 m)-5.9 (C)2.6 (i)2.6 ( )11.2 (r)-5.9 (em)-5.9 (ai)2.6 (n)]TJ 0 Tc 0 Tw (s)Tj 17.109 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (n t)-6.6 (he)10.5 ( w)13.5 (hol)2.6 (e body)8.9 ( 48 hour)-6 (s)8.9 ( a)10.5 (f)-6.6 (t)-6.6 (er)4.9 ( )]TJ 0.005 Tc -0.005 Tw -17.391 -1.38 Td [(tr)1 (e)6.7 (a)17.5 (tm)1.1 (e)6.6 (n)17.6 (t.)11.2 ( )]TJ -0.002 Tc 0.007 Tw 4.761 0 Td [(T)-10.6 (he ad)10.5 (m)-5.9 (i)2.6 (ni)2.6 (s)-2 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(E)2 (K)1.9 ( i)2.6 (nhi)2.7 (bi)2.6 (t)-6.6 (or)-6 ( \()4.9 (s)-2 (el)2.6 (um)-5.9 (et)-6.6 (i)2.6 (ni)2.6 (b\))-5.9 ( s)-2 (i)13.5 (g)-11.2 (ni)13.5 (f)-17.5 (i)2.6 (c)-2 (an)10.5 (t)-6.6 (l)2.6 (y)8.9 ( )]TJ 0 -1.37 Td [(i)2.6 (nc)-2 (r)-6 (eas)-2 (ed )11.3 (t)-6.6 (he e)10.5 (f)-6.6 (f)-6.6 (ec)8.9 (t)-6.6 (i)2.6 (v)8.9 (enes)-2 (s)-2 ( o)10.5 (f)-6.6 ( R)]TJ 14.185 0 Td [(A)2 (I)4.2 ( t)-6.6 (he)10.5 (r)-6 (apy)8.9 ( i)2.6 (n pat)-6.6 (i)13.4 (ent)-6.6 (s)-2 ( w)13.5 (ho w)13.5 (er)-6 (e pr)-6 (ev)8.9 (i)2.6 (ous)-2 (l)2.6 (y)8.9 ( )]TJ 0.004 Tc 0.001 Tw -14.185 -1.38 Td [(R)8.6 (A)8 (I)-0.7 ( re)16.5 (f)-0.6 (ra)5.7 (c)14.9 (t)-0.7 (o)5.7 (ry)14.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 94.56 411.6 Tm (271)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 106.08 407.64 Tm ( )Tj 0.283 0 Td ( )Tj EMC /H3 <>BDC /TT2 1 Tf 0.008 Tc -0.008 Tw 9.96 -0 0 9.96 23.52 382.32 Tm [(Po)-7.5 (s)-2.3 (t)]TJ 0 Tc 0 Tw 2.217 0 Td (-)Tj 0.016 Tc -0.016 Tw 0.349 0 Td [(T)0.5 (r)7.4 (e)5.8 (a)5.7 (tm)1.4 (e)5.7 (n)0.5 (t )]TJ 0.018 Tc -0.018 Tw 6.48 -0 0 6.48 101.28 385.8 Tm (131)Tj 0.011 Tc 0 Tw 9.96 -0 0 9.96 112.44 382.32 Tm [(I Im)-3.6 (a)0.8 (g)-4.6 (i)12 (n)-4.6 (g)]TJ 0 Tc 4.482 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.013 Tc 0.013 Tw 11.04 -0 0 11.04 23.52 366.96 Tm [(W)-36.4 (hen)-11.4 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 55.44 370.92 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 66.96 366.96 Tm [(I)-6.6 ( t)-6.6 (he)10.6 (r)-6 (apy)8.9 ( i)2.6 (s)-2 ( )11.3 (g)-11.3 (i)2.7 (v)8.8 (en,)-6.6 ( w)13.5 (hol)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 11.022 0 Td [(body)8.8 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 215.52 370.92 Tm [(13)-17 (1)]TJ -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 227.16 366.96 Tm [(I)-6.6 ( i)2.6 (m)-6 (a)10.6 (g)-11.2 (i)2.6 (ng s)-2 (houl)2.6 (d be )11.3 (per)4.9 (f)-6.6 (or)4.9 (m)-5.9 (ed )]TJ -18.446 -1.37 Td [(s)-2 (ev)8.8 (er)-6 (al)2.6 ( day)8.9 (s)-2 ( l)2.6 (at)-6.6 (er)-6 ( )11.3 (t)-6.6 (o)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.002 Tw 9.207 0 Td [(doc)8.9 (um)-5.9 (ent)4.2 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 176.52 355.8 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 188.04 351.84 Tm [(I)-6.6 ( upt)-6.6 (a)10.5 (k)-12.9 (e)10.6 ( by)8.9 ( t)-6.6 (he)10.6 ( )11.2 (t)-6.6 (um)-6 (o)10.5 (r)-5.9 (.)4.2 ( P)2 (os)-2 (t)]TJ 0 Tc 0 Tw 11.913 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(t)4.3 (r)-6 (eat)4.3 (m)-6 (en)10.5 (t)-6.6 ( )]TJ -0.016 Tc 0.016 Tw -27.152 -1.38 Td [(wh)-14.4 (o)-25.2 (l)-11.4 (e)]TJ 0 Tc 0 Tw 2.598 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(body)8.8 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 82.8 340.56 Tm [(13)-17 (1)]TJ -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 94.44 336.6 Tm [(I)-6.6 ( i)2.6 (m)-6 (a)10.6 (g)-11.2 (i)2.6 (ng )11.2 (s)-2 (houl)2.6 (d be done)10.5 (,)-6.6 ( p)10.6 (r)-6 (i)2.6 (m)-5.9 (ar)-6 (i)2.7 (l)13.4 (y)8.9 ( bec)-2 (aus)-2 (e up )11.2 (t)-6.6 (o 25)10.5 (%)-4.3 ( )0.5 (o)10.5 (f)-6.6 ( )]TJ -6.424 -1.37 Td [(i)2.6 (m)-5.9 (ag)-11.2 (es)8.9 ( s)-2 (how)13.5 ( l)2.6 (es)-2 (i)2.6 (ons)-2 ( t)-6.6 (ha)10.6 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(n 27)10.6 (%)-4.3 ( o)10.6 (f)-6.6 ( )11.2 (t)-6.6 (h)10.5 (e t)4.3 (r)-6 (eat)4.3 (m)-6 (ent)4.3 ( c)-2 (y)8.8 (c)-2 (l)2.7 (es)-2 (,)-6.6 ( bu)10.5 (t)-6.6 ( )]TJ -2.217 -1.38 Td [(onl)2.6 (y)8.9 ( 10%)-4.3 ( o)10.5 (f)-17.5 ( )11.3 (t)-6.6 (he)10.6 ( pos)-2 (t)]TJ 0 Tc 0 Tw 9.033 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(t)4.3 (r)-6 (ea)10.5 (t)-6.6 (m)-6 (en)10.5 (t)-6.6 ( i)13.5 (m)-6 (a)10.5 (g)-11.2 (i)2.6 (ng s)-2 (how)13.5 (ed c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 (l)-8.3 (y)8.9 ( s)-2 (i)2.6 (g)]TJ 17.217 0 Td [(ni)2.6 (f)-17.5 (i)2.6 (c)-2 (an)10.6 (t)-6.6 ( new)13.5 ( )]TJ -26.587 -1.37 Td [(f)-6.6 (oc)-2.1 (i)2.7 ( o)10.5 (f)-6.6 ( )11.2 (m)-5.9 (et)-6.6 (as)8.8 (t)-6.6 (at)-6.6 (i)2.6 (c)8.9 ( di)2.6 (s)-2 (eas)8.9 (e.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 150.12 264.72 Tm (272)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 161.64 260.76 Tm ( )Tj -0.004 Tc 0.004 Tw 0.283 0 Td [(Po)-2.4 (s)-4 (t)]TJ 0 Tc 0 Tw 2 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(t)4.3 (r)-6 (eat)4.3 (m)-6 (en)10.5 (t)-6.6 ( i)2.6 (m)-6 (a)10.6 (g)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( w)13.4 (as)-2 ( m)-6 (o)10.6 (s)-2 (t)4.2 ( l)2.6 (i)2.6 (k)-12.8 (el)2.6 (y)8.9 ( t)-6.6 (o )]TJ -15.13 -1.38 Td [(r)-6 (ev)8.9 (eal)2.6 ( c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)-8.2 (l)2.6 (y)8.8 ( i)2.7 (m)-6 (por)-6 (t)-6.6 (ant)-6.6 ( new)13.5 ( i)2.6 (n)10.5 (f)-17.4 (or)4.9 (m)-5.9 (at)-6.6 (i)2.6 (on i)2.6 (n)10.6 ( pat)-6.6 (i)2.6 (e)10.5 (nt)-6.6 (s)-2 ( y)8.9 (oung)-11.3 (e)10.6 (r)-6 ( )11.3 (t)-6.6 (han)10.5 ( 45 )]TJ 0 -1.37 Td [(y)8.9 (ear)-6 (s)-2 ( w)13.5 (ho had r)-6 (ec)-2 (ei)2.6 (v)8.9 (ed )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 142.8 234.36 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 154.32 230.4 Tm [(I)-6.6 ( t)-6.6 (her)-6 (apy)8.9 ( i)2.6 (n t)-6.6 (he)10.5 ( pas)-2 (t)4.3 (.)4.3 ( C)2.7 (onv)8.9 (er)-6 (s)-2 (el)2.6 (y)8.9 (,)-6.6 ( i)2.6 (n ol)2.6 (der)-6 ( )]TJ -11.848 -1.38 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( and)10.5 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (ho had no)10.5 (t)-6.6 ( p)10.5 (r)-5.9 (ev)8.9 (i)2.6 (ous)-2 (l)2.6 (y)8.9 ( r)-6 (ec)-2 (ei)2.7 (v)8.8 (ed )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 288.24 219.12 Tm [(1)-17 (31)]TJ -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 299.88 215.16 Tm [(I)-6.6 ( t)-6.6 (her)-6 (a)]TJ -0.011 Tc 0.011 Tw [(p)-9.4 (y,)-15.6 ( )]TJ -0.002 Tc 0.002 Tw -25.033 -1.37 Td [(pos)-2 (t)]TJ 0 Tc 0 Tw 1.891 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( i)13.5 (m)-6 (a)10.6 (g)-11.3 (i)2.7 (ng r)4.9 (ar)-5.9 (el)2.6 (y)8.9 ( y)8.9 (i)2.6 (e)-11.2 (l)2.6 (ded new)13.5 ( i)2.6 (nf)-17.5 (or)5 (m)4.9 (at)-6.6 (i)2.6 (on t)-6.6 (ha)10.5 (t)-6.6 ( al)13.5 (t)-6.6 (er)-6 (ed)10.5 ( t)-6.6 (he)10.6 ( )]TJ -2.217 -1.38 Td [(pat)-6.6 (i)2.6 (ent)-6.6 <92>2.6 (s)-2 ( p)10.5 (r)-5.9 (o)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 118.44 188.76 Tm (272)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 129.96 184.8 Tm ( )Tj 0.283 0 Td ( )Tj EMC /H2 <>BDC /TT1 1 Tf 0.009 Tc -0.004 Tw -9.924 -2.391 Td [(A)24.5 (s)-11.1 (sessm)-4.1 (en)11.3 (t)-5.9 ( )-10.4 (a)10.6 (n)0.5 (d M)-5.8 (a)10.6 (n)0.5 (a)10.6 (g)0.5 (em)-4.1 (en)11.3 (t)5 ( )-21.3 (A)35.3 (f)-5.8 (t)-5.8 (er)-4.1 ( I)-6.5 (n)11.3 (i)-6.5 (t)5.1 (i)-6.5 (a)10.7 (l)4.3 ( )-10.4 (T)11.3 (r)-4.2 (e)10.7 (at)-5.9 (m)6.7 (ent)]TJ 0 Tc 0 Tw 25.304 0 Td ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw -25.587 -1.696 Td [(S)2 (er)-5.9 (um)4.9 ( )11.3 (Tg)-11.2 ( de)10.6 (t)-6.7 (er)4.9 (m)-5.9 (i)2.6 (nat)-6.6 (i)2.6 (on)10.6 (s)-2.1 (,)-6.6 ( nec)8.8 (k)-2 ( ul)2.6 (t)4.2 (r)-5.9 (as)-2 (ound)10.5 (,)-6.6 ( and)10.5 ( )11.3 (w)13.5 (ho)-11.2 (l)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 24.196 0 Td [(body)8.8 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 317.52 143.64 Tm [(13)-17 (1)]TJ -0.005 Tc 0.01 Tw 11.04 -0 0 11.04 329.16 139.68 Tm [(I)-9.6 ( im)-9 (a)7.5 (g)-14.2 (in)-3.3 (g)-3.4 ( )]TJ -0.002 Tc 0.007 Tw -27.685 -1.38 Td [(det)-6.6 (ec)-1.9 (t)4.2 ( r)-5.9 (ec)-2 (u)10.5 (r)-5.9 (r)-6 (en)10.5 (t)-6.6 ( )11.3 (or)4.9 ( r)-5.9 (es)-2 (i)2.6 (d)10.6 (ual)2.6 ( di)2.6 (s)-2 (eas)-2 (e i)2.6 (n )11.3 (m)-5.9 (os)-2 (t)4.3 ( pat)-6.6 (i)2.6 (e)10.5 (nt)-6.7 (s)-2 ( )0.5 (w)13.4 (ho hav)8.9 (e )]TJ 0.002 Tw [(under)4.9 (g)-11.2 (one)10.5 ( )]TJ -0.004 Tw 0 -1.37 Td [(t)-6.6 (ot)-6.7 (al)2.6 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (abl)2.7 (at)-6.6 (i)2.6 (on.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 125.16 113.28 Tm (273)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 136.68 109.32 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)4.3 (n c)-2 (ont)4.3 (r)-6 (as)-2 (t)4.2 (,)4.3 ( nei)2.6 (t)-6.6 (her)4.9 ( s)-2 (er)-6 (u)10.6 (m)4.9 ( )11.2 (Tg)-11.2 ( no)10.5 (r)-6 ( w)13.5 (hol)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 17.663 0 Td [(body)8.8 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 361.68 113.28 Tm [(13)-17 (1)]TJ 0.005 Tc -0.005 Tw 11.04 -0 0 11.04 373.32 109.32 Tm (I )Tj -0.002 Tc 0.007 Tw -31.685 -1.38 Td [(i)2.6 (m)-5.9 (ag)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( i)2.6 (s)8.9 ( s)-2 (pec)-2 (i)13.5 (f)-17.5 (i)2.6 (c)8.9 ( )11.2 (f)-17.4 (o)10.5 (r)-6 ( )11.3 (t)-6.6 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.7 (nom)-6 (a i)2.7 (n)10.5 ( pat)-6.6 (i)2.6 (en)10.6 (t)-6.7 (s)-2 ( w)13.5 (ho hav)8.9 (e not)-6.6 ( )]TJ 0 -1.37 Td [(under)4.9 (g)-11.2 (one )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (dec)-2 (t)-6.6 (om)4.9 (y)8.9 ( and r)-5.9 (em)-6 (nan)10.5 (t)-6.6 ( )11.3 (abl)2.6 (at)-6.7 (i)2.7 (on.)-6.7 ( )11.3 (W)-25.4 (h)10.5 (e)10.6 (n i)2.6 (ni)2.6 (t)-6.6 (i)2.6 (al)2.6 ( abl)2.6 (at)-6.6 (i)2.6 (v)]TJ 0.002 Tw 29.75 0 Td (e )Tj 0.007 Tw -29.75 -1.38 Td [(t)-6.6 (her)-6 (apy)8.9 ( has)-2 ( b)10.5 (een c)-2 (o)10.5 (m)-5.9 (pl)13.5 (et)-6.7 (ed,)4.3 ( s)-2 (er)-6 (u)10.5 (m)-5.9 ( )11.3 (Tg s)-2 (houl)2.6 (d b)10.5 (e m)-6 (eas)-2 (u)10.5 (r)-6 (ed pe)10.5 (r)-6 (i)2.6 (odi)2.7 (c)-2 (al)2.6 (l)2.6 (y)8.9 (.)-6.6 ( )]TJ 0 -1.37 Td [(S)2 (er)-5.9 (um)4.9 ( )11.3 (Tg)-11.2 ( c)-2 (an)10.6 ( be )11.2 (m)-5.9 (eas)-2 (u)10.5 (r)-6 (ed w)13.4 (hi)2.6 (l)2.6 (e t)-6.7 (he pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 ( i)2.6 (s)-2 ( )11.3 (t)-6.6 (a)10.5 (k)-12.9 (i)2.7 (n)10.5 (g)-11.3 ( )11.3 (t)-6.6 (hy)8.8 (r)-5.9 (ox)8.9 (i)2.6 (ne,)-6.6 ( but)4.3 ( t)-6.6 (he)10.5 ( )]TJ 34.554 42.152 Td [(t)-6.6 (es)-2 (t)4.3 ( i)2.6 (s)-2 ( )11.3 (m)-6 (or)-6 (e)10.5 ( s)-1.9 (ens)-1.9 (i)2.6 (t)-6.7 (i)2.7 (v)8.8 (e w)13.5 (h)-11.3 (en t)-6.6 (hy)8.9 (r)-6 (ox)8.8 (i)2.6 (ne has)-2.1 ( been )11.2 (s)-2 (t)4.3 (opped or)4.9 ( w)13.5 (hen )]TJ 0 -1.38 Td [(r)-6 (ec)-2 (om)-5.9 (bi)2.7 (nan)10.5 (t)-6.6 ( hu)10.5 (m)-5.9 (an )11.3 (T)-10.6 (S)2 (H)13.4 ( \()-5.9 (r)-6 (h)10.5 (T)-10.5 (S)1.9 (H)13.5 (\))-5.9 ( i)2.6 (s)-2 ( )11.3 (g)-11.3 (i)2.6 (v)8.9 (en t)-6.6 (o)10.5 ( i)2.6 (nc)-2 (r)-6 (e)10.6 (as)]TJ 23.152 0 Td [(e t)-6.6 (he)10.5 ( s)-2 (er)-6 (u)10.5 (m)5 ( )]TJ -0.005 Tc 0.005 Tw -23.152 -1.37 Td [(T)-13.6 (S)-1 (H.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 430.2 487.56 Tm [(274,)-1.8 (27)-17 (5)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 455.28 483.6 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -4.837 -2.38 Td [(U)2.6 (s)-2 (i)2.6 (ng)-11.2 ( c)-2.1 (u)10.6 (r)-6 (r)-5.9 (en)10.5 (t)-6.6 ( )11.3 (Tg as)-2 (s)-2 (ay)8.8 (s)-2 (,)4.3 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h m)-6 (eas)]TJ 19.565 0 Td [(u)10.5 (r)-5.9 (abl)2.6 (e s)-2 (er)-6 (u)10.6 (m)-6 ( )11.3 (Tg l)2.6 (ev)8.8 (el)2.6 (s)-2 ( dur)-5.9 (i)2.6 (ng )]TJ -19.565 -1.37 Td [(T)-10.6 (S)2 (H)2.6 ( s)-2 (upp)10.5 (r)-5.9 (es)-2 (s)-2 (i)2.6 (on and)10.6 ( )11.2 (t)-6.6 (h)10.6 (os)-2 (e w)13.5 (i)2.6 (t)-6.6 (h s)-2 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (at)-6.7 (ed)10.5 ( )11.3 (Tg)-11.2 ( l)2.6 (e)10.5 (v)8.9 (el)2.6 (s)-2 ( m)-5.9 (or)-5.9 (e )11.3 (t)-6.6 (han )0.5 (2)10.5 ( n)10.5 (g)-11.2 (/)4.2 (m)-5.9 (L)10.5 ( )]TJ 0 -1.38 Td [(ar)-6 (e )0.5 (l)2.6 (i)2.6 (k)-12.9 (el)2.7 (y)8.8 ( t)-6.6 (o)10.5 ( hav)8.9 (e r)-6 (es)-2 (i)2.6 (dua)10.5 (l)2.6 (/)-6.6 (r)-6 (ec)-2 (ur)4.9 (r)-6 (ent)4.3 ( di)2.6 (s)-2 (eas)-2 (e )11.3 (t)-6.6 (ha)10.5 (t)-6.6 ( )11.3 (m)-6 (ay)8.9 ( be l)2.6 (oc)-2 (al)2.6 (i)2.6 (z)8.9 (ed i)2.6 (n )]TJ 0 -1.37 Td [(al)2.6 (m)-6 (os)-1.9 (t)4.2 ( 50%)6.6 ( pr)-5.9 (o)10.5 (m)-5.9 (pt)-6.6 (l)2.6 (y)8.9 ( an)10.6 (d i)2.6 (n an addi)2.6 (t)-6.6 (i)2.6 (onal)2.6 ( 30)10.6 (%)-4.3 ( o)10.5 (v)8.9 (er)-5.9 ( t)-6.7 (he )0.5 (nex)8.8 (t)4.3 ( 3 )11.3 (t)-6.6 (o 5)10.6 ( )]TJ 0.002 Tw 0 -1.38 Td [(y)8.9 (ear)-6 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 435 400.56 Tm (276)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 446.52 396.6 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 (bout)-6.6 ( 6%)6.5 ( o)10.6 (f)-6.7 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h det)-6.7 (e)10.6 (c)-2 (t)-6.7 (abl)2.6 (e )11.3 (s)-2 (er)5 (um)-5.9 ( )11.2 (Tg l)2.6 (ev)8.9 (el)2.6 (s)-2 ( \()-6 (w)13.5 (hi)2.7 (c)-2 (h ar)-6 (e )]TJ -4.043 -1.37 Td [(<)-5 (2 n)10.5 (g/)-6.6 (m)-6 (L)10.5 ( a)10.6 (f)-6.7 (t)-6.6 (er)4.9 ( s)8.9 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (at)-6.6 (i)2.6 (o)10.6 (n\))-6 ( w)13.5 (i)2.6 (l)2.6 (l)2.7 ( ha)-11.2 (v)8.9 (e r)-5.9 (ec)-2 (ur)4.9 (r)-6 (enc)-2 (es)-2 ( )11.3 (ov)8.9 (er)-5.9 ( t)-6.6 (he nex)8.8 (t)4.3 ( 3 )11.3 (t)-6.6 (o 5)10.5 ( )]TJ 0 -1.38 Td [(y)8.9 (ear)-6 (s)-2 (,)-6.6 ( w)13.5 (her)-6 (eas)-1.9 ( onl)2.6 (y)8.8 ( abo)]TJ [(ut)-6.7 ( 2)10.6 (%)-4.4 ( )0.5 (o)10.5 (f)-6.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h c)-2 (om)-6 (pl)2.6 (et)-6.6 (el)2.6 (y)8.9 ( undet)-6.6 (ec)-2 (t)-6.6 (a)10.6 (bl)2.6 (e )]TJ 0 -1.37 Td [(s)-2 (er)-6 (um)5 ( )11.2 (Tg)-11.2 ( a)10.5 (f)-6.6 (t)-6.6 (e)10.5 (r)-5.9 ( )11.3 (s)-2 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (a)10.5 (t)-6.6 (i)2.6 (on w)13.5 (i)2.6 (l)-8.3 (l)2.6 ( hav)8.9 (e r)-5.9 (ec)-2 (ur)-5.9 (r)-6 (enc)-2 (es)8.8 ( o)10.6 (v)8.8 (er)-6 ( t)-6.6 (he nex)8.9 (t)4.2 ( )0.5 (3 )11.3 (t)-6.7 (o 5)10.5 ( )]TJ -0.004 Tw 0 -1.38 Td [(y)8.9 (ear)-6 (s)-2 (.)-6.6 ( T)-10.6 (he )-10.6 (l)2.6 (on)10.5 (g)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 7.207 0 Td [(t)-6.6 (e)10.5 (r)-5.9 (m)4.9 ( c)-2 (l)2.6 (i)2.6 (ni)2.7 (c)-2.1 (al)2.6 ( s)-2 (i)2.6 (g)-11.2 (ni)13.4 (f)-17.4 (i)2.6 (c)-2 (anc)-2 (e i)2.6 (s)8.9 ( unc)-2 (e)10.5 (r)-5.9 (t)4.2 (ai)2.6 (n )11.2 (f)-17.5 (or)4.9 ( di)2.6 (s)-2 (eas)-2 (e onl)2.6 (y)8.9 ( )]TJ -7.207 -1.37 Td [(det)-6.6 (ec)-1.9 (t)-6.7 (ed)10.5 ( by)8.8 ( m)-5.9 (i)2.6 (ni)2.7 (m)-6 (al)2.6 (l)2.6 (y)8.8 ( el)2.6 (ev)8.8 (at)-6.6 (ed Tg l)2.6 (ev)8.9 (el)2.6 (s)-2 ( a)10.5 (f)-17.4 (t)-6.6 (e)10.5 (r)-6 ( s)8.9 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (at)-6.7 (i)2.7 (on.)]TJ 0 Tc 0 Tw 25.478 0 Td ( )Tj /CS0 cs 0.122 0.102 0.09 scn /TT3 1 Tf 0.272 0 Td ( )Tj EMC /H3 <>BDC /CS1 cs 0 scn /TT2 1 Tf 0.01 Tc -0.01 Tw 9.96 -0 0 9.96 405 295.44 Tm [(R)-3 (eco)-5.5 (m)]TJ 0.016 Tc -0.017 Tw 3.398 0 Td [(b)0.5 (i)4.9 (n)0.5 (a)5.7 (n)0.5 (t )-12.1 (H)3 (u)0.5 (m)1.4 (a)5.7 (n)0.5 ( TS)8.4 (H)]TJ 0 Tc 0 Tw 9.145 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.005 Tc -0.001 Tw 11.04 -0 0 11.04 405 280.08 Tm [(Du)-3.4 (r)-8.9 (in)-3.4 (g)-14.2 ( f)-9.7 (o)-3.3 (llo)-3.3 (w)]TJ 0 Tc 0 Tw 5.75 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up,)-6.6 ( per)-6 (i)2.7 (odi)2.7 (c)-2 ( w)13.4 (i)2.7 (t)-6.7 (hdr)-5.9 (aw)13.4 (al)2.6 ( of)-17.4 ( )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d h)10.5 (or)-6 (m)-5.9 (one)10.5 ( t)-6.6 (he)10.6 (r)-6 (apy)8.9 ( has)-2 ( )]TJ -6.087 -1.38 Td [(t)-6.6 (r)-6 (adi)2.7 (t)-6.7 (i)2.7 (onal)2.6 (l)2.6 (y)8.9 ( been us)-2 (ed )11.2 (t)-6.6 (o)10.6 ( i)2.7 (nc)-2 (r)-5.9 (eas)-2 (e)10.5 ( t)-6.6 (he)10.6 ( s)-2.1 (er)-6 (u)10.6 (m)-6 ( )11.3 (T)-10.6 (S)2 (H)13.5 ( c)-2 (onc)-2 (ent)4.2 (r)-5.9 (at)-6.6 (i)2.6 (ons)8.9 ( )]TJ 0 -1.37 Td [(s)-2 (u)10.5 (f)-6.6 (f)-17.5 (i)2.7 (c)-2.1 (i)2.7 (ent)-6.6 (l)2.6 (y)8.8 ( t)-6.6 (o)10.6 ( s)-2 (t)-6.7 (i)13.5 (m)-5.9 (ul)2.6 (at)-6.6 (e )11.3 (t)4.2 (hy)8.9 (r)-6 (oi)2.6 (d t)-6.6 (i)2.6 (s)-2 (s)-2 (ue s)-2 (o)10.6 ( t)-6.7 (ha)10.5 (t)-6.6 ( s)-2 (e)10.5 (r)-5.9 (u)10.5 (m)-5.9 ( )11.2 (Tg m)-6 (ea)10.5 (s)-2 (ur)-5.9 (e)10.5 (m)-5.9 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ 0 -1.37 Td [(\()-6 (or)-6 ( w)13.5 (i)2.6 (t)-6.6 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0 773 0 obj << /Length 774 0 R >> stream Q q BT /Xi79 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. 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(hy)8.9 (r)-6 (oi)2.6 (d hor)5 (m)-6 (one )]TJ 0.002 Tw 0 -1.38 Td [(w)2.6 (i)2.6 (t)-6.6 (hdr)-5.9 (aw)13.5 (al)2.7 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 78.48 502.68 Tm [(27)-17 (5)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 90.12 498.72 Tm ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(D)2.6 (at)-6.6 (a )-10.6 (s)-2 (how)13.5 (ed )-10.6 (t)-6.6 (ha)10.6 (t)-6.6 ( t)-6.6 (he )-10.6 (c)-2 (o)10.5 (m)-5.9 (bi)2.7 (nat)-6.7 (i)2.6 (on o)10.6 (f)-17.5 ( r)-5.9 (h)10.5 (T)-10.6 (S)2 (H)]TJ 0 Tc 0 Tw 19.337 0 Td <96>Tj -0.005 Tc 0.005 Tw 0.554 0 Td [(s)-5 (t)-9.6 (im)-9 (u)-3.3 (la)]TJ -0.013 Tc 0.013 Tw 3.163 0 Td [(t)-17.6 (e)-11.3 (d )]TJ -0.016 Tc 0.016 Tw -29.37 -1.37 Td [(wh)-14.4 (o)-25.2 (l)-11.4 (e)]TJ 0 Tc 0 Tw 2.598 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(body)8.8 ( i)2.6 (m)-5.9 (ag)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( and)10.6 ( )11.2 (s)-2 (er)-6 (um)4.9 ( )11.3 (Tg)-11.3 ( )11.3 (m)-6 (eas)-2 (u)10.5 (r)-6 (em)-6 (en)10.5 (t)-6.6 (s)8.9 ( det)-6.6 (ec)8.9 (t)-6.6 (ed 100)10.5 (%)-4.3 ( o)10.5 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[(I)-6.6 ( on t)-6.6 (he )11.2 (t)-6.5 (hi)2.6 (r)-5.9 (d)10.5 ( day)8.8 (.)-6.5 ( )22.1 (W)-36.3 (h)10.5 (o)10.6 (l)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 11.152 0 Td [(body)8.8 ( i)2.6 (m)-5.9 (ag)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( and)10.6 ( )11.2 (Tg)-11.2 ( )11.3 (m)-6 (eas)-2 (ur)-6 (e)10.5 (m)-5.9 (en)10.6 (t)-6.6 (s)-2 ( w)13.4 (er)-6 (e )]TJ -0.004 Tw -12.196 -1.37 Td [(per)4.9 (f)-17.5 (o)10.6 (r)-6 (m)-5.9 (ed)10.5 ( )-10.6 (on t)-6.6 (he f)-6.6 (i)13.4 (f)-6.6 (t)-6.6 (h )-10.6 (da)10.5 (y)8.9 (.)-6.6 ( )11.1 (W)-36.2 (h)10.5 (ol)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 15.076 0 Td [(body)8.8 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 216.84 426.84 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 228.36 422.88 Tm [(I)-6.6 ( i)2.6 (m)-6 (a)10.6 (g)-11.2 (e)10.5 (s)-2 ( w)13.5 (er)-6 (e ac)8.9 (q)-11.2 (ui)2.6 (r)-6 (ed a)10.5 (f)-6.6 (t)-6.6 (e)10.5 (r)-5.9 ( )11.2 (30 )]TJ -18.554 -1.38 Td [(m)-6 (i)2.7 (nut)-6.5 (es)8.9 ( o)10.5 (f)-6.6 ( i)2.6 (m)-6 (a)10.6 (g)-11.3 (i)2.7 (n)10.5 (g)-11.2 ( o)10.5 (r)-6 ( a)10.5 (f)-6.6 (t)4.3 (er)-6 ( ob)10.6 (t)-6.6 (ai)2.6 (ni)2.6 (ng)-11.2 ( 140)10.5 (,)-6.6 (000)10.6 ( c)-2 (ou)10.5 (nt)-6.6 (s)-2 (,)4.2 ( w)13.5 (hi)2.6 (c)-2 (hev)8.9 (er)-5.9 ( c)-2 (am)-5.9 (e )]TJ 0.016 Tc -0.016 Tw 0 -1.37 Td [(f)0.5 (i)]TJ -0.002 Tc 0.007 Tw 0.5 0 Td [(r)-6 (s)-2 (t)4.3 (.)-6.6 ( A)12.8 ( s)-2 (er)-6 (u)10.5 (m)5 ( )11.2 (Tg)-11.2 ( o)10.5 (f)-6.6 ( 2)10.5 (.)-6.6 (0 n)10.5 (g/)-6.7 (m)-5.9 (L)10.5 ( or)4.9 ( hi)2.6 (g)-11.2 (he)10.5 (r)-6 (,)4.3 ( ob)10.5 (t)-6.6 (ai)2.6 (ned )11.3 (72 hour)-5.9 (s)8.8 ( a)10.6 (f)-6.7 (t)-6.6 (er)4.9 ( t)-6.6 (he)10.6 ( l)2.6 (as)-2 (t)4.3 ( )]TJ -0.5 -1.38 Td [(r)-6 (hT)-10.6 (S)2 (H)13.5 ( i)2.6 (nj)-8.2 (ec)8.9 (t)-6.6 (i)2.6 (on,)-6.6 ( i)2.6 (ndi)2.6 (c)-2 (at)-6.6 (e)10.5 (s)-2 ( t)-6.6 (ha)10.6 (t)-6.7 ( )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d t)-6.6 (i)2.6 (s)-2 (s)-2 (ue)10.6 ( or)4.9 ( t)-6.6 (h)10.5 (y)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a i)2.6 (s)8.9 ( )]TJ 0 -1.37 Td [(pr)-6 (es)-2 (ent)4.2 (,)-6.6 ( )11.3 (r)-6 (e)10.6 (g)-11.3 (ar)-6 (dl)2.6 (es)-2 (s)8.9 ( o)10.5 (f)-6.6 ( t)-6.6 (h)10.5 (e w)13.5 (hol)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 14.511 0 Td [(body)8.8 ( )-10.6 (i)2.6 (m)-5.9 (ag)-11.2 (i)2.6 (ng f)-17.5 (i)2.6 (n)10.6 (di)2.6 (ng)-11.2 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 293.4 366.12 Tm [(275,)-1.8 (27)-17 (8)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 318.48 362.16 Tm ( )Tj 0.283 0 Td ( )Tj EMC /H3 <>BDC /TT2 1 Tf 0.016 Tc -0.005 Tw 9.96 -0 0 9.96 23.52 336.72 Tm [(M)17.7 (e)-6.3 (a)5.7 (s)5.8 (u)0.5 (r)7.4 (i)4.8 (n)0.5 (g)0.5 ( S)8.3 (e)5.7 (r)7.4 (u)0.5 (m)1.4 ( T)0.5 (g)0.5 ( a)5.7 (n)0.6 (d)0.5 ( A)3.1 (n)0.5 (ti)]TJ 0 Tc 0 Tw 14.506 0 Td (-)Tj 0.016 Tc -0.005 Tw 0.349 0 Td [(T)12.5 (g)0.5 ( A)3.1 (n)0.5 (ti)16.9 (b)0.5 (o)0.5 (d)0.5 (i)4.8 (e)5.8 (s)]TJ 0 Tc 0 Tw 6.819 0 Td ( )Tj 0.277 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 321.48 Tm [(S)2 (er)-5.9 (um)4.9 ( )11.3 (Tg)-11.2 ( )11.3 (m)-6 (eas)-2 (ur)-5.9 (e)10.5 (m)-5.9 (en)10.5 (t)-6.6 ( )11.3 (i)2.6 (s)-2 ( t)-6.6 (he be)10.5 (s)-2 (t)4.2 ( m)-5.9 (ean)10.5 (s)-2 ( o)10.5 (f)-6.6 ( de)10.5 (t)4.3 (ec)-2 (t)-6.6 (i)2.6 (ng t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )11.3 (t)-6.7 (i)2.7 (s)-2 (s)-2 (ue,)4.2 ( )]TJ 0 -1.38 Td [(i)2.6 (nc)-2 (l)2.6 (udi)2.6 (ng)-11.2 ( c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-6 (a.)4.3 ( )11.2 (Tg)-11.2 ( )11.3 (c)-2 (an be )11.3 (m)-6 (eas)-2 (u)10.5 (r)-5.9 (ed w)13.5 (hen )11.3 (T)-10.6 (S)2 (H)2.6 ( has)8.9 ( been )]TJ 0.002 Tw 0 -1.37 Td [(s)-2 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (at)-6.6 (ed)]TJ 0 Tc 0 Tw 4.543 0 Td <97>Tj (e)Tj -0.002 Tc 0.007 Tw 1.554 0 Td [(i)2.6 (t)-6.6 (her)4.9 ( by)8.8 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (d hor)4.9 (m)-5.9 (one w)13.5 (i)2.6 (t)-6.6 (hdr)-5.9 (aw)13.5 (al)-8.3 ( or)5 ( by)8.9 ( r)-6 (h)10.5 (T)-10.5 (S)1.9 (H)]TJ 0 Tc 0 Tw 21.38 0 Td <97>Tj ( )Tj -0.002 Tc 0.002 Tw 1.283 0 Td [(bec)-2 (au)10.5 (s)-2 (e )]TJ 0.007 Tw -28.761 -1.38 Td [(i)2.6 (n t)-6.6 (hi)2.6 (s)-2 ( s)-2 (e)10.5 (t)-6.6 (t)-6.6 (i)2.6 (n)10.6 (g)-11.3 (,)4.3 ( s)-2 (e)10.5 (r)-5.9 (um)4.9 ( )11.3 (Tg)-11.2 ( )11.2 (has)-2 ( a l)2.6 (ow)13.4 (er)-5.9 ( )11.2 (f)-17.5 (al)2.6 (s)-2 (e)]TJ 0 Tc 0 Tw 18.337 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(ne)10.5 (g)-11.2 (at)-6.6 (i)2.6 (v)8.9 (e r)-5.9 (a)10.5 (t)-6.6 (e )11.3 (t)-6.6 (han w)13.4 (hol)2.7 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 11.185 0 Td [(body)8.8 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 23.52 264.72 Tm (131)Tj -0.005 Tc 0.01 Tw 11.04 -0 0 11.04 35.04 260.76 Tm [(I)-9.6 ( im)-9 (a)-3.3 (g)-14.3 (in)7.6 (g)-14.3 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 83.04 264.72 Tm (274)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 1.983 0 Td [(27)-17 (6,)-19.1 (279)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 122.04 260.76 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(S)2 (er)-16.8 (um)-5.9 ( )11.2 (Tg l)2.6 (ev)8.8 (el)2.6 (s)-2 ( v)8.9 (ar)-5.9 (y)8.8 ( i)2.7 (n r)-6 (es)-2 (pons)-2.1 (e t)-6.6 (o)10.5 ( t)-6.6 (he)10.5 ( i)2.6 (nc)-2 (r)-5.9 (eas)-2 (e)10.5 ( i)2.6 (n )]TJ -9.207 -1.38 Td [(s)-2 (er)-6 (um)5 ( )11.2 (T)-10.5 (S)1.9 (H)2.6 ( a)10.6 (f)-6.6 (t)-6.7 (e)10.6 (r)-6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d hor)-6 (m)-5.9 (one)10.5 ( w)13.5 (i)2.6 (t)-6.6 (hdr)-6 (aw)13.4 (al)2.6 ( or)-6 ( r)4.9 (hT)-10.6 (S)2 (H)2.6 ( s)8.8 (t)-6.6 (i)2.6 (m)-5.9 (ul)2.6 (at)-6.6 (i)2.6 (on)10.6 (.)-6.6 ( S)1.9 (er)-6 (u)10.5 (m)5 ( )]TJ 0 -1.37 Td [(Tg )11.2 (g)-11.2 (ener)-6 (al)2.6 (l)2.6 (y)8.9 ( does)-2 ( not)4.3 ( i)2.6 (n)10.5 (c)-2 (r)-6 (eas)-2 (e a)10.5 (s)-2 ( )11.3 (m)-6 (uc)-2 (h a)10.6 (f)-6.6 (t)4.2 (er)4.9 ( r)-6 (h)10.6 (TS)1.9 (H)2.6 ( adm)-5.9 (i)2.6 (ni)2.7 (s)-2.1 (t)-6.6 (r)-5.9 (a)10.5 (t)-6.6 (i)2.6 (on as)8.8 ( )]TJ 0 -1.38 Td [(a)10.5 (f)-17.4 (t)-6.7 (e)10.6 (r)-6 ( w)13.5 (i)2.6 (t)-6.6 (hdr)-6 (aw)13.5 (al)2.6 ( of)-6.6 ( t)-6.6 (hy)8.9 (r)-6 (oi)]TJ 10.804 0 Td [(d hor)4.9 (m)-6 (one.)]TJ 0 Tc 0 Tw 5.043 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.272 0 Td [(T)-10.6 (he c)-2 (ondi)2.6 (t)-6.6 (i)2.6 (ons)-2 ( f)-17.5 (o)10.5 (r)-6 ( r)-6 (h)10.6 (T)-10.6 (S)2 (H)]TJ 0 Tc 0 Tw 11.087 0 Td <96>Tj -0.002 Tc 0.002 Tw 0.554 0 Td [(s)-2 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (a)10.5 (t)-6.6 (ed,)4.3 ( )]TJ -0.016 Tc 0.016 Tw -27.761 -1.37 Td [(wh)-14.4 (o)-25.2 (l)-11.4 (e)]TJ 0 Tc 0 Tw 2.598 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(body)8.8 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 82.8 204 Tm [(13)-17 (1)]TJ -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 94.44 200.04 Tm [(I)-6.6 ( i)2.6 (m)-6 (a)10.6 (g)-11.2 (i)2.6 (ng )11.2 (s)-2 (t)-6.6 (i)2.6 (pul)2.7 (at)-6.6 (e us)-2 (i)2.6 (n)10.5 (g)-11.2 ( 4)]TJ 0 Tc 0 Tw 11.533 0 Td (-)Tj -0.005 Tc 0.005 Tw 0.326 0 Td [(m)-9 (Ci )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 248.04 204 Tm (131)Tj -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 259.56 200.04 Tm [(I)-6.6 ( )-10.6 (dos)-2 (es)-2 ( \()-5.9 (bas)-2 (ed)10.5 ( )-10.6 (on t)-6.6 (he )]TJ -0.005 Tc 0.005 Tw -21.38 -1.38 Td [(t)-9.6 (r)-9 (ia)-3.3 (l\))]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 45 188.76 Tm (275)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 56.52 184.8 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(and an i)2.6 (m)-6 (a)10.5 (g)-11.2 (i)2.6 (n)10.6 (g t)-6.6 (i)13.5 (m)-6 (e o)10.5 (f)-6.6 ( 30)10.6 ( m)-5.9 (i)2.6 (nu)10.5 (t)]TJ 14.185 0 Td [(es)-2 ( o)10.5 (r)-6 ( un)10.5 (t)-6.6 (i)2.6 (l)2.6 ( 140,)-6.6 (000)10.6 ( c)-2 (ount)4.3 (s)-2 ( a)10.5 (r)-5.9 (e )]TJ -17.457 -1.37 Td [(obt)-6.6 (ai)2.7 (ned.)-6.6 ( )11.3 (Tg m)5 (eas)-2 (ur)-5.9 (e)10.5 (m)-6 (e)10.5 (nt)-6.6 (s)-2 ( )11.3 (m)-6 (ay)8.9 ( al)2.6 (s)-2 (o be )11.3 (obt)-6.6 (ai)2.6 (ned)10.5 ( w)13.5 (i)2.6 (t)-6.6 (hout)-6.6 ( s)-2 (t)-6.6 (i)13.5 (m)-6 (ul)2.6 (at)-6.7 (i)2.7 (ng )11.2 (T)-10.5 (S)1.9 (H)2.6 ( )]TJ 0 -1.38 Td [(us)-2 (i)2.6 (ng)-11.2 ( ul)13.5 (t)-6.6 (r)-5.9 (as)-2 (ens)-2 (i)13.5 (t)-6.6 (i)2.6 (v)8.9 (e as)-2 (s)-2 (ay)8.9 (s)-2 ( \()-6 (i)2.7 (e,)-6.6 ( )]TJ 0.002 Tw [(s)-2 (ec)-2 (ond)]TJ 0 Tc 0 Tw 17.011 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.326 0 Td [(g)-11.2 (ener)-5.9 (a)10.5 (t)-6.6 (i)2.6 (o)]TJ 0 Tc 0 Tw 4.152 0 Td (n)Tj 0.554 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(Tg)-11.2 ( i)2.6 (m)4.9 (m)-5.9 (uno)10.5 (m)-6 (et)4.2 (r)-5.9 (i)2.6 (c)-2 ( )]TJ 0 Tc 0.005 Tw -22.315 -1.37 Td [(a)1.7 (ssa)1.6 (y)10.9 (s [)]TJ -0.018 Tc 0.018 Tw 3.652 0 Td [(T)-15.7 (g)-27.2 (I)-22.7 (MA)-14 (s)]TJ 0 Tc 0 Tw 3.435 0 Td (])Tj 0.283 0 Td (\))Tj 0.337 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 111.72 143.28 Tm [(280,)-1.8 (2)]TJ (81)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 136.68 139.32 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)-6.6 (t)-6.6 ( i)2.6 (s)-2 ( us)-1.9 (e)10.5 (f)-6.6 (ul)2.6 ( t)-6.6 (o)10.5 ( m)-5.9 (ea)10.6 (s)-2.1 (ur)-6 (e)10.6 ( s)-2 (er)4.9 (um)-6 ( )11.3 (Tg and an)10.5 (t)-6.6 (i)]TJ 0 Tc 0 Tw 18.076 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.326 0 Td (Tg )Tj -0.004 Tw -28.935 -1.38 Td [(ant)-6.6 (i)2.6 (body)8.8 ( )-10.6 (l)2.6 (ev)8.9 (e)-11.3 (l)2.7 (s)-2 ( f)-17.5 (or)4.9 ( f)-17.5 (ol)2.6 (l)2.6 (ow)]TJ 0 Tc 0 Tw 10.859 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(up )-10.6 (and)10.5 ( )-10.6 (as)-2 (s)-2 (es)-2 (s)-2 (i)2.6 (n)10.6 (g)-11.2 ( t)-6.6 (r)4.9 (end pat)-6.7 (t)-6.6 (e)10.6 (r)-6 (ns)-2 (.)4.2 ( )]TJ 0 Tc 0 Tw ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -11.196 -2.37 Td [(T)-10.6 (he)10.5 ( s)-2 (ens)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (i)2.6 (t)-6.6 (y)8.9 ( and s)-2 (pec)-2 (i)2.6 (f)-17.4 (i)2.6 (c)-2 (i)2.6 (t)-6.6 (y)8.8 ( )0.5 (o)10.5 (f)-6.6 ( v)8.8 (ar)-6 (i)2.6 (ous)-2 ( )11.3 (Tg as)-2 (s)-2 (ay)8.8 (s)-2 (,)-6.6 ( how)13.5 (ev)8.8 (er)-6 (,)-6.6 ( v)8.9 (ar)-6 (y)8.9 ( w)13.4 (i)2.7 (de)-11.2 (l)-8.3 (y)8.9 ( )]TJ 0 -1.37 Td [(i)2.6 (n di)2.6 (f)-6.6 (f)-6.6 (er)-6 (en)10.6 (t)-6.6 ( l)2.6 (abo)10.5 (r)-6 (at)-6.6 (o)10.5 (r)-5.9 (i)2.6 (es)-2 (,)4.3 ( )11.3 (ev)8.9 (en w)2.6 (i)2.6 (t)-6.6 (h )0.5 (t)-6.7 (he )]TJ [(u)10.6 (s)-2 (e o)10.5 (f)-6.6 ( an)10.5 ( i)2.6 (nt)-6.7 (er)-5.9 (na)10.5 (t)-6.6 (i)2.6 (onal)2.6 ( s)-2 (t)-6.6 (anda)10.6 (r)-6 (d )]TJ -0.005 Tc 0.01 Tw 0 -1.38 Td [(\()-9 (CRM)12.8 ( 4)-3.3 (5)-3.4 (7)]TJ 0.004 Tc -0.004 Tw 4.533 0 Td (\).)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 80.4 71.52 Tm (282,)Tj 1.948 0 Td [(28)-17 (3)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 105.6 67.56 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (hus)8.9 (,)-6.6 ( i)2.6 (t)4.3 ( i)2.6 (s)-2 ( r)-6 (e)10.6 (c)-2 (om)4.9 (m)-5.9 (ended )11.3 (t)-6.6 (hat)4.3 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( unde)10.5 (r)4.9 (g)-11.2 (o)10.5 ( )11.3 (Tg)-11.2 ( )]TJ -7.717 -1.37 Td [(m)-6 (oni)2.7 (t)-6.6 (or)-5.9 (i)2.6 (n)10.5 (g v)8.9 (i)2.6 (a t)-6.6 (he s)-2 (a)10.5 (m)-6 (e )11.3 (Tg a)]TJ [(s)-2 (s)-2 (ay)8.9 ( per)4.9 (f)-6.6 (or)5 (m)-6 (ed i)2.6 (n )11.2 (t)-6.6 (h)10.5 (e s)-2 (am)-5.9 (e)10.5 ( l)2.6 (abor)-6 (a)10.5 (t)-6.5 (or)-5.9 (y)8.8 (.)-6.6 ( )]TJ 34.554 41.804 Td [(I)-6.6 (deal)2.7 (l)2.6 (y)8.9 (,)-6.7 ( s)-2 (er)-6 (um)4.9 ( i)2.6 (s)-2 ( )11.3 (f)-6.6 (r)-6 (oz)8.8 (en a)10.6 (nd s)-2 (av)8.9 (ed )11.3 (f)-17.5 (or)4.9 ( )11.3 (f)-6.6 (ut)-6.7 (u)10.6 (r)-6 (e anal)2.6 (y)8.9 (s)-2 (es)-2 ( i)13.4 (f)-6.6 ( needed,)4.2 ( es)-2 (pec)-2 (i)2.6 (al)2.6 (l)2.7 (y)-2 ( )]TJ 0 -1.38 Td [(s)-2 (houl)2.6 (d a c)-2 (han)10.5 (g)-11.2 (e)10.5 ( i)2.6 (n )11.2 (Tg)-11.2 ( a)10.5 (s)-1.9 (s)-2.1 (ay)8.9 ( be nec)-2 (es)-2 (s)-2 (a)10.5 (r)-5.9 (y)8.9 (.)-6.6 ( A)1.9 (s)-2 ( )11.3 (t)-6.6 (h)10.5 (e s)-2 (ens)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.8 (i)2.6 (t)-6.6 (y)8.9 ( of)-6.7 ( )]TJ 0 -1.37 Td [(c)-2 (om)-6 (m)-6 (e)10.6 (r)-6 (c)-2 (i)2.6 (al)2.6 (l)2.6 (y)8.9 ( av)8.9 (ai)-8.2 (l)2.6 (abl)2.6 (e T)-10.5 (g as)-2 (s)-2 (ay)8.9 (s)-2 ( i)2.6 (m)-5.9 (p)10.5 (r)-6 (ov)8.9 (es)-2 (,)-6.6 ( t)-6.6 (he)10.6 ( n)10.5 (eed )11.2 (f)-17.5 (o)10.6 (r)-6 ( s)8.9 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (at)-6.6 (ed)10.5 ( )11.3 (Tg)-11.2 ( )]TJ 0.005 Tc -0.005 Tw 0 -1.38 Td [(te)6.6 (s)5 (t)0.5 (i)9.6 (n)]TJ -0.002 Tc 0.007 Tw 2.38 0 Td [(g)-11.2 ( )11.2 (m)-5.9 (ay)8.9 ( bec)-2 (o)10.5 (m)-5.9 (e l)2.7 (es)-2 (s)8.9 ( i)2.6 (m)-6 (por)4.9 (t)-6.6 (ant)4.3 (.)]TJ 0 Tc 0 Tw 13.304 0 Td ( )Tj 0.272 0 Td ( )Tj EMC /P <>BDC -0.004 Tc 0.004 Tw -15.957 -2.37 Td [(An)-2.4 (t)-8.6 (i)]TJ 0 Tc 0 Tw 1.717 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(Tg)-11.2 ( an)10.6 (t)-6.7 (i)2.7 (bodi)2.6 (es)-2 ( s)-2 (houl)2.6 (d be )11.3 (m)-6 (eas)-2 (ur)-6 (ed)10.5 ( i)2.6 (n )11.2 (t)-6.6 (he s)-2 (a)10.6 (m)-6 (e s)-2 (e)10.6 (r)-6 (um)4.9 ( s)-2 (a)10.5 (m)-6 (pl)2.6 (e )11.2 (t)-6.6 (a)10.5 (k)-12.8 (en )]TJ -2.043 -1.38 Td [(f)-6.6 (or)5 ( )11.2 (Tg)-11.2 ( as)-2 (s)-2 (ay)8.9 (,)4.2 ( bec)-2.1 (aus)-2 (e)10.5 ( t)-6.6 (h)10.5 (es)-2.1 (e ant)-6.6 (i)2.6 (bodi)2.6 (es)-2 ( )11.3 (\()-6 (w)13.5 (hi)2.6 (c)-2 (h ar)-6 (e )11.3 (f)-17.5 (ound)10.6 ( i)2.6 (n )]TJ /C2_0 1 Tf 0 Tc 0 Tw 26.315 0 Td <0094>Tj /TT0 1 Tf -0.002 Tc 0.007 Tw 0.554 0 Td [(25%)6.6 ( o)10.5 (f)-6.6 ( )]TJ -26.87 -1.37 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (d c)8.9 (ar)-5.9 (c)8.9 (i)2.6 (nom)-6 (a\))-6 ( i)2.6 (nv)8.8 (al)2.6 (i)2.6 (dat)-6.6 (e s)-2 (er)-5.9 (u)10.5 (m)-6 ( )11.3 (Tg m)-5.9 (eas)-2 (u)10.5 (r)-5.9 (e)10.5 (m)-6 (ent)-6.6 (s)8.9 ( i)2.6 (n )]TJ 0 Tc 0.005 Tw 0 -1.38 Td [(m)-4 (o)1.7 (st)6.3 ( a)1.6 (ssa)1.6 (y)10.9 (s.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 469.32 400.56 Tm [(280,)-1.8 (28)-17 (3,)-1.9 (2)-16.9 (84)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 507.96 396.6 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (hes)-2 (e ant)-6.6 (i)2.6 (bodi)2.6 (es)-2 ( )11.3 (t)-6.6 (y)8.9 (pi)2.6 (c)-2 (al)2.6 (l)-8.3 (y)8.9 ( f)-6.6 (al)2.6 (s)-2 (el)2.6 (y)8.9 ( l)2.6 (o)-11.2 (w)13.5 (er)-5.9 ( t)-6.6 (he )11.2 (Tg)-11.2 ( v)8.9 (al)2.6 (ue )]TJ -9.609 -1.37 Td [(i)2.6 (n i)2.6 (m)-6 (m)-6 (unoc)-2 (he)10.5 (m)-6 (i)2.7 (l)2.6 (um)-6 (i)2.7 (nom)4.9 (et)-6.6 (r)-5.9 (i)2.6 (c)-2 ( a)10.5 (s)-2 (s)-2 (ay)8.8 (s)-2 ( \()4.9 (I)-6.6 (C)2.6 (M)15.8 (A)2 (s)-2 (\))-6 ( and i)2.6 (m)-6 (m)-5.9 (uno)10.5 (r)-5.9 (adi)2.6 (om)-5.9 (e)10.5 (t)-6.6 (r)-6 (i)2.6 (c)8.9 ( )]TJ 0 -1.38 Td [(as)-2 (s)-2 (ay)8.9 (s)-2 ( \()-6 (I)-6.6 (R)2.6 (M)15.8 (A)2 (s)-2 (\))-6 (,)-6.6 ( w)13.5 (hi)2.6 (l)2.6 (e r)-6 (ai)2.6 (s)-2 (i)2.6 (ng)-11.3 ( )11.3 (t)-6.6 (he v)8.9 (al)2.7 (ue )0.5 (i)2.6 (n ol)2.6 (der)-6 ( )11.3 (r)-6 (a)10.6 (di)2.6 (oi)2.6 (m)-6 (m)-5.9 (unoas)-2 (s)-2 (ay)8.9 (s)-2 (.)-6.6 ( )]TJ -0.005 Tc 0.01 Tw 0 -1.37 Td [(A)-1 (lt)-9.7 (h)-3.3 (o)-3.4 (u)-3.3 (g)-14.2 (h)7.5 ( t)-9.6 (h)-3.4 (e)7.5 ( c)-5 (lin)-3.4 (ic)-5 (a)-3.3 (l im)-9 (p)]TJ -0.002 Tc 0.007 Tw 10.75 0 Td [(or)-6 (t)-6.6 (anc)-2 (e)10.5 ( o)10.5 (f)-6.6 ( ant)-6.6 (i)]TJ 0 Tc 0 Tw 6.326 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(Tg an)10.5 (t)-6.6 (i)2.6 (bodi)2.6 (es)-2 ( i)2.6 (s)-2 ( unc)-2 (l)2.6 (ear)4.9 (,)-6.6 ( )11.3 (t)-6.7 (hei)2.6 (r)-6 ( )]TJ -17.402 -1.38 Td [(per)-6 (s)-2 (i)2.7 (s)-2 (t)-6.7 (enc)-2 (e)10.5 ( )11.2 (f)-17.4 (o)10.5 (r)-6 ( )11.3 (m)-6 (or)-6 (e)10.6 ( t)-6.6 (h)10.5 (a)10.5 (n 1 y)8.9 (ear)-6 ( a)10.5 (f)-6.6 (t)-6.6 (e)10.6 (r)-6 ( )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (dec)-2 (t)-6.6 (o)10.5 (m)-5.9 (y)8.8 ( and R)2.6 (A)2 (I)4.2 ( abl)2.6 (at)-6.6 (i)2.6 (on )]TJ 0 -1.37 Td [(pr)-6 (obabl)2.6 (y)8.9 ( i)2.6 (ndi)2.6 (c)-2 (at)-6.7 (es)-2 ( t)-6.6 (he)10.5 ( pr)4.9 (es)-2 (enc)-2 (e o)10.6 (f)-6.6 ( r)-6 (e)10.5 (s)-2 (i)2.6 (dual)2.6 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d t)-6.6 (i)2.6 (s)-2 (s)-2 (ue)10.6 ( and pos)8.9 (s)-2 (i)2.6 (bl)2.7 (y)8.8 ( an )]TJ -0.004 Tw 0 -1.38 Td [(i)2.6 (nc)-2 (r)-6 (eas)-2 (ed r)-6 (i)2.7 (s)-2 (k)-2 ( )-10.7 (o)10.6 (f)-6.6 ( r)-5.9 (ec)-2 (ur)4.9 (r)-6 (e)10.6 (nc)-2 (e.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 543.84 309.48 Tm (284)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 555.36 305.52 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -13.902 -2.37 Td [(I)-6.6 (n one)10.6 ( s)-2 (t)-6.6 (udy)8.8 (,)4.3 ( 49%)6.6 ( o)10.5 (f)-6.6 ( pat)-6.6 (i)13.5 (ent)-6.6 (s)-2 ( had)10.5 ( a )11.3 (r)-5.9 (ec)-2 (u)10.5 (r)-5.9 (r)-6 (enc)-2 (e)10.5 ( i)13.5 (f)-17.5 ( )11.3 (t)4.3 (hey)8.8 ( had undet)-6.6 (ec)8.8 (t)-6.6 (abl)2.6 (e )]TJ 0 -1.37 Td [(s)-2 (er)-6 (um)5 ( )11.2 (Tg)-11.2 ( and)10.6 ( s)-2 (e)10.5 (r)-6 (um)4.9 ( ant)-6.6 (i)]TJ 0 Tc 0 Tw 11.076 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(Tg an)10.5 (t)-6.6 (i)2.6 (body)8.9 ( l)2.6 (ev)8.9 (e)-11.2 (l)2.6 (s)-2 ( o)10.5 (f)-17.5 ( 10)10.5 (0 uni)2.6 (t)-6.6 (s)-2 (/)4.2 (m)-5.9 (L)10.5 ( or)5 ( m)-6 (o)10.5 (r)-5.9 (e w)13.5 (hen )]TJ -11.413 -1.38 Td [(c)-2 (om)-6 (par)-5.9 (ed)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h onl)2.6 (y)8.9 ( 3%)-4.3 ( )11.3 (o)10.5 (f)-17.5 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h undet)-6.6 (ec)-2 (t)4.3 (abl)2.6 (e )]TJ [(s)-2 (er)-5.9 (u)10.5 (m)-6 ( )11.3 (Tg and s)-2 (e)10.5 (r)-5.9 (u)10.5 (m)-6 ( )]TJ 0.002 Tw 0 -1.37 Td [(ant)-6.6 (i)]TJ 0 Tc 0 Tw 1.609 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(Tg)-11.2 ( an)10.6 (t)-6.7 (i)2.7 (bodi)2.6 (es)-2 ( o)10.5 (f)-6.6 ( l)2.6 (es)-2 (s)8.8 ( t)-6.6 (han)10.5 ( )0.5 (100 uni)2.6 (t)4.3 (s)-2 (/)4.2 (m)-5.9 (L.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 621 237.84 Tm (285)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 632.52 233.88 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)-6.6 (n)10.5 ( )11.3 (pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h c)-2 (oex)8.9 (i)2.6 (s)-2 (t)-6.6 (ent)4.3 ( )]TJ -20.891 -1.38 Td [(aut)-6.6 (oi)2.7 (m)-6 (m)-5.9 (u)10.5 (ne )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d di)2.6 (s)-2 (eas)-2 (e at)4.2 ( )0.5 (t)-6.6 (he)10.5 ( t)-6.6 (i)13.5 (m)-6 (e o)10.5 (f)-6.6 ( s)-2 (u)10.5 (r)4.9 (g)-11.2 (er)4.9 (y)8.9 (,)-6.7 ( )0.5 (ant)-6.6 (i)]TJ 0 Tc 0 Tw 24.272 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.326 0 Td [(Tg)-11.2 ( )-10.6 (an)10.6 (t)-6.7 (i)2.7 (bodi)2.6 (es)-2 ( m)-6 (a)10.5 (y)8.9 ( )]TJ 0.007 Tw -24.598 -1.37 Td [(per)-6 (s)-2 (i)2.7 (s)-2 (t)4.2 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )11.3 (f)-6.7 (ar)4.9 ( l)2.6 (ong)-11.2 (e)10.5 (r)-5.9 (.)4.2 ( I)-6.6 (n)10.5 ( a)10.6 ( s)-1.9 (t)-6.6 (udy)8.8 ( o)10.6 (f)-6.7 ( 116)10.6 ( pat)-6.6 (i)2.6 (ent)4.2 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h ant)-6.6 (i)]TJ 0 Tc 0 Tw 24.489 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(Tg ant)-6.7 (i)2.7 (bodi)2.6 (es)-2 ( )]TJ -24.815 -1.38 Td [(be)10.5 (f)-17.5 (or)-5.9 (e)10.5 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d)]TJ [(ec)-1.9 (t)-6.7 (o)10.6 (m)-6 (y)8.9 (,)-6.6 ( an)10.5 (t)-6.6 (i)2.6 (bodi)2.6 (es)-2 ( r)-6 (e)10.5 (m)-5.9 (ai)2.6 (ned det)-6.6 (e)10.5 (c)-2 (t)4.3 (abl)2.6 (e )11.3 (f)-17.5 (or)4.9 ( up )11.3 (t)-6.6 (o 20)10.5 ( y)8.9 (ear)-6 (s)-2 ( i)2.6 (n)10.5 ( )]TJ 0 -1.37 Td [(s)-2 (om)-6 (e pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (hout)-6.6 ( de)10.5 (t)-6.6 (ec)-2 (t)-6.7 (abl)2.7 (e )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d t)-6.5 (i)2.5 (s)-1.9 (s)-2.1 (ue)10.5 (,)-6.6 ( a)10.5 (nd t)-6.6 (he)10.5 ( m)-5.9 (edi)2.6 (an)10.5 ( t)-6.6 (i)2.6 (m)-5.9 (e)10.5 ( t)-6.6 (o)10.5 ( )]TJ 0 -1.38 Td [(di)2.6 (s)-2 (appear)-5.9 (anc)-2 (e o)10.6 (f)-6.6 ( an)10.5 (t)-6.6 (i)2.6 (bodi)2.6 (es)-2.1 ( w)13.5 (as)-2 ( 3 y)8.9 (ear)-6 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 607.56 161.88 Tm (286)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 619.08 157.92 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(P)2 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h per)-5.9 (s)-2 (i)2.6 (s)8.9 (t)-6.6 (ent)-6.6 (l)2.6 (y)8.8 ( )]TJ -19.674 -1.37 Td [(undet)-6.6 (ec)-2 (t)-6.6 (abl)2.6 (e)10.5 ( s)-2 (er)-5.9 (u)10.5 (m)-6 ( )11.3 (Tg a)10.5 (nd ant)-6.6 (i)]TJ 0 Tc 0 Tw 14.022 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(Tg ant)-6.7 (i)2.7 (body)8.9 ( l)2.6 (ev)8.9 (el)-8.3 (s)-2 ( hav)]TJ 9.913 0 Td [(e l)2.6 (ong)-11.2 (e)10.5 (r)-6 ( di)2.6 (s)-2 (eas)-2 (e)]TJ 0 Tc 0 Tw 7.315 0 Td (-)Tj -0.002 Tc 0.007 Tw -31.576 -1.38 Td [(f)-6.6 (r)-6 (ee)10.5 ( s)-2 (ur)-6 (v)8.9 (i)2.6 (v)8.9 (al)2.6 ( )-10.4 (w)13.4 (hen c)-2 (om)-5.9 (p)10.5 (ar)-6 (ed w)13.5 (i)2.6 (t)-6.6 (h pat)-6.6 (i)2.6 (ent)-6.7 (s)8.9 ( w)13.5 (ho hav)8.9 (e det)-6.6 (ec)-2 (t)-6.6 (abl)2.6 (e l)2.6 (ev)8.9 (el)2.6 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 748.08 131.52 Tm (287)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 759.6 127.56 Tm ( )Tj 0.283 0 Td ( )Tj EMC /H3 <>BDC /TT2 1 Tf 9.96 -0 0 9.96 405 102.24 Tm (T)Tj 0.016 Tc -0.005 Tw 0.627 0 Td [(r)7.4 (e)5.8 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EMC ET endstream endobj 779 0 obj 27965 endobj %% Contents for page 82 %% Original object ID: 165 0 780 0 obj << /Length 781 0 R >> stream Q q BT /Xi80 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 781 0 obj 245 endobj %% Contents for page 83 %% Original object ID: 166 0 782 0 obj << /Length 783 0 R >> stream q endstream endobj 783 0 obj 2 endobj %% Contents for page 83 %% Original object ID: 11415 0 784 0 obj << /Length 785 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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)Tj -0.002 Tc 0.007 Tw 10.033 0 Td [(p)10.5 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h pr)-5.9 (o)10.5 (gr)-6 (es)-2 (s)-2 (i)2.6 (v)8.9 (e )11.3 (m)-6 (et)-6.6 (as)8.9 (t)-6.6 (at)-6.6 (i)2.6 (c)8.9 ( di)2.6 (s)-2 (eas)-2 (e.)4.3 ( )22.1 (W)-36.2 (h)10.5 (e)10.5 (n )]TJ -10.033 -1.37 Td [(a l)2.7 (ar)4.9 (g)-11.2 (e )11.2 (t)-6.6 (um)-6 (o)10.5 (r)-5.9 ( i)2.6 (s)8.9 ( not)4.2 ( v)8.9 (i)2.6 (s)-2 (i)2.6 (bl)-8.3 (e on di)2.6 (a)10.5 (g)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)-2 ( w)13.5 (hol)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 20.935 0 Td [(body)8.8 ( i)2.6 (m)-5.9 (ag)-11.2 (i)2.6 (n)10.6 (g)-11.3 (,)4.3 ( i)2.6 (t)-6.6 (s)8.9 ( abi)2.6 (l)2.6 (i)2.6 (t)-6.6 (y)8.9 ( t)-6.6 (o )]TJ 0.002 Tw -20.935 -1.38 Td [(c)-2 (onc)-2 (ent)-6.6 (r)-5.9 (a)10.5 (t)-6.6 (e )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 84.24 279.12 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 95.76 275.16 Tm [(I)-6.6 ( i)2.6 (s)8.9 ( v)8.8 (er)-6 (y)8.9 ( l)2.6 (ow)13.4 (;)-6.6 ( t)-6.6 (hus)-2 (,)4.3 ( t)-6.6 (he)10.6 ( t)-6.5 (u)10.5 (m)-6 (or)4.9 ( w)13.5 (i)2.6 (l)2.6 (l)2.6 ( no)-11.2 (t)-6.6 ( )11.3 (r)-6 (es)-2 (pond )11.3 (t)-6.7 (o )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 327.6 279.12 Tm (131)Tj -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 339.12 275.16 Tm [(I)-6.6 ( t)-6.6 (her)-6 (apy)8.9 (.)-6.6 ( )]TJ 0 Tc 0 Tw ( )Tj EMC /H3 <>BDC /TT2 1 Tf 0.016 Tc -0.005 Tw 9.96 -0 0 9.96 23.52 249.84 Tm [(T)0.5 (h)0.5 (y)5.7 (r)7.5 (o)0.5 (i)4.8 (d)0.5 ( H)3 (o)0.5 (r)7.4 (m)1.4 (o)0.5 (n)0.5 (e)5.8 ( S)8.3 (u)0.5 (p)0.5 (p)0.5 (r)7.5 (e)17.7 (s)5.8 (s)5.7 (i)4.9 (o)0.5 (n)0.5 ( o)0.5 (f T)0.5 (S)8.3 (H)]TJ 0 Tc 0 Tw 18.578 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf 11.04 -0 0 11.04 23.52 234.6 Tm (T)Tj -0.002 Tc 0.007 Tw 0.62 0 Td [(he)10.5 ( us)-2 (e o)10.5 (f)]TJ 0 Tc 0 Tw 4.098 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(po)10.5 (s)-2 (t)-6.6 (ope)10.5 (r)-6 (at)-6.6 (i)2.6 (v)8.9 (e )]TJ 0.007 Tw 6.25 0 Td [(l)2.6 (ev)8.8 (ot)-6.6 (hy)8.9 (r)-6 (ox)-2 (i)2.6 (ne t)-6.6 (o )]TJ 0.002 Tw [(dec)8.8 (r)-5.9 (eas)8.8 (e)]TJ 0 Tc 0 Tw ( )Tj -0.005 Tc 0.01 Tw 11.62 0 Td [(T)-13.6 (S)-1 (H le)-3.4 (v)5.9 (e)-3.4 (ls)-5 ( is)-5 ( )]TJ -0.002 Tc 0.007 Tw -22.87 -1.38 Td [(c)-2 (ons)-2 (i)2.6 (der)-5.9 (ed op)10.6 (t)-6.7 (i)2.7 (m)-6 (al)2.6 ( i)2.6 (n )11.3 (t)-6.6 (r)-6 (e)10.5 (at)-6.6 (m)-6 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (i)2.6 (t)-6.6 (h papi)2.6 (l)2.7 (l)2.6 (ar)-5.9 (y)8.8 (,)-6.6 ( f)-17.4 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 (,)-6.6 ( o)10.5 (r)-5.9 ( )]TJ 0 -1.37 Td [(H)2.6 -6 (t)-6.6 (hl)2.6 (e c)-2 (el)2.6 (l)2.6 ( c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-6 (a)]TJ 0 Tc 0 Tw 9.859 0 Td (,)Tj 0.283 0 Td ( )Tj 0.283 0 Td (b)Tj -0.002 Tc 0.007 Tw 0.543 0 Td [(ec)-2 (aus)-1.9 (e )11.3 (T)-10.6 (S)2 (H)2.6 ( i)2.6 (s)-2 ( a)10.5 ( )11.3 (t)-6.6 (r)-6 (ophi)2.6 (c)-2 ( )11.2 (hor)-6 (m)-6 (one)10.5 ( t)-6.6 (ha)10.5 (t)-6.6 ( c)8.9 (an )]TJ -10.967 -1.38 Td [(s)-2 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (at)-6.6 (e)10.5 ( t)-6.6 (he)10.6 ( )11.2 (g)-11.2 (r)-6 (ow)13.5 (t)-6.6 (h o)10.5 (f)-6.6 ( c)8.9 (el)2.6 (l)2.7 (s)-2 ( der)-6 (i)2.6 (v)8.9 (ed f)-6.6 (r)-6 (om)4.9 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )0.5 (f)-6.7 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (a)]TJ 0.004 Tc -0.004 Tw (r )Tj -0.002 Tc 0.002 Tw 0 -1.37 Td [(epi)2.6 (t)-6.6 (hel)2.6 (i)2.6 (um)-6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 76.8 177.84 Tm [(3,)-1.9 (243)-17 (,)-1.9 (29)-16.9 (1,)-19.1 (292)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 121.32 173.88 Tm ( )Tj 0.009 Tc -0.009 Tw 0.283 0 Td [(H)13.6 (ow)24.5 (ev)19.8 (e)10.7 (r)5 (,)4.4 ( )]TJ -0.002 Tc 0.007 Tw 4.5 0 Td [(t)-6.6 (he)10.6 ( opt)-6.6 (i)2.6 (m)-6 (al)13.5 ( )]TJ [(s)-2 (er)-6 (u)10.6 (m)-6 ( l)2.6 (ev)8.8 (el)2.6 (s)-2 ( o)10.5 (f)-17.5 ( )11.3 (T)-10.6 (S)2 (H)]TJ 0 Tc 0 Tw 14.12 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(hav)8.9 (e not)-6.6 ( )]TJ -28.043 -1.38 Td [(been de)10.5 (f)-17.5 (i)2.6 (ned be)10.5 (c)-2 (aus)-2 (e o)10.5 (f)4.3 ( a l)2.6 (ac)8.9 (k)-2 ( o)10.5 (f)-6.6 ( s)]TJ -0.004 Tw 15.685 0 Td [(pec)-2 (i)13.5 (f)-17.5 (i)2.6 (c)8.9 ( )-10.6 (dat)-6.6 (a)10.5 (;)-6.6 ( t)4.2 (her)-5.9 (e)10.5 (f)-17.5 (o)10.6 (r)-6 (e,)]TJ 0 Tc 0 Tw 9.848 0 Td ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(t)-9.6 (h)-3.4 (e)7.6 ( NCCN )]TJ -0.002 Tc 0.007 Tw -25.815 -1.37 Td [(P)2 (anel)2.6 ( r)-5.9 (ec)-2 (om)4.9 (m)-6 (ends)8.9 ( t)-6.6 (ai)2.6 (l)2.6 (or)4.9 (i)2.6 (ng)-11.3 ( )11.3 (t)-6.6 (he de)10.6 (gr)-5.9 (ee o)10.5 (f)-6.6 ( )11.3 (T)-10.6 (S)2 (H)13.4 ( s)-2 (u)10.6 (ppr)-5.9 (es)-2 (s)-2 (i)2.6 (on )11.2 (t)-6.6 (o )11.3 (t)-6.7 (he )11.3 (r)-5.9 (i)2.6 (s)8.8 (k)-12.8 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.38 Td [(r)-6 (ec)-2 (ur)5 (r)-6 (enc)-2 (e and)10.5 ( dea)10.5 (t)-6.6 (h )11.2 (f)-6.6 (r)-5.9 (o)10.5 (m)-6 ( )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 ( )11.2 (f)-17.5 (o)10.6 (r)-6 ( ea)10.5 (c)8.9 (h i)2.6 (ndi)2.6 (v)8.9 (i)2.6 (dua)-11.2 (l)2.6 ( pat)-6.6 (i)2.6 (ent)-6.6 (.)4.3 ( For)4.9 ( )]TJ 0 -1.37 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h )11.3 (k)-12.9 (now)13.5 (n r)-6 (es)-2 (i)13.5 (dual)2.6 ( c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( or)5 ( t)-6.6 (ho)10.5 (s)-2 (e )11.3 (at)-6.6 ( hi)13.4 (g)-11.2 (h )11.2 (r)-5.9 (i)2.6 (s)8.9 (k)-12.9 ( )11.2 (f)-6.6 (or)4.9 ( )]TJ 0.002 Tw 0 -1.38 Td [(r)-6 (ec)-2 (ur)5 (r)-6 (enc)-2 (e)]TJ 0 Tc 0 Tw (,)Tj 5.043 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(t)-6.6 (he)10.6 ( r)-6 (e)10.5 (c)-2 (om)4.9 (m)4.9 (ended)]TJ 0 Tc 0 Tw ( )Tj -0.005 Tc 0.01 Tw 8.293 0 Td [(T)-13.6 (S)-1 (H le)-3.4 (v)5.9 (e)-3.4 (l )]TJ -0.002 Tc 0.007 Tw [(i)2.6 (s)-2 ( bel)2.6 (ow)13.5 ( 0.)-6.6 (1 m)-6 (i)2.6 (l)2.6 (l)2.6 (i)2.6 (uni)2.6 (t)-6.6 (s)-2 (/)-6.6 (L.)4.3 ( For)4.9 ( )]TJ 0 Tc 0 Tw -13.62 -1.37 Td (p)Tj -0.002 Tc 0.002 Tw 0.554 0 Td [(at)-6.7 (i)2.7 (ent)-6.7 (s)]TJ 0 Tc 0 Tw 2.946 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(a)10.5 (t)4.3 ( l)2.6 (ow)13.5 ( r)-5.9 (i)2.6 (s)-2 (k)-12.9 ( an)10.5 (d )11.3 (f)4.2 (or)-5.9 ( )11.2 (t)-6.6 (hos)-2 (e pa)10.5 (t)-6.6 (i)2.6 (ent)-6.7 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h an )11.2 (ex)8.8 (c)-2 (el)2.6 (l)2.6 (ent)-6.6 ( r)-5.9 (es)-2 (pons)-2 (e )11.3 (t)-6.6 (o )]TJ -3.783 -1.38 Td [(i)2.6 (ni)2.6 (t)-6.6 (i)2.6 (al)2.6 ( t)-6.6 (her)-5.9 (apy)8.9 ( w)13.4 (ho ar)-6 (e i)2.6 (n )11.3 (r)-5.9 (em)-6 (i)2.7 (s)-2 (s)-2 (i)2.6 (on,)]TJ 0 Tc 0 Tw 15.565 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(t)-6.6 (he)10.6 ( r)-6 (e)10.5 (c)-2 (om)4.9 (m)-6 (e)10.6 (nded)]TJ 0 Tc 0 Tw ( )Tj -0.005 Tc 0.01 Tw 8.293 0 Td [(T)-13.6 (S)-1 (H le)-3.4 (v)5.9 (e)-3.4 (l)]TJ 0 Tc 0 Tw ( )Tj -0.005 Tc 0.005 Tw 4.598 0 Td [(is)-5 ( )]TJ -0.002 Tc 0.002 Tw 1 0 Td [(ei)2.6 (t)-6.6 (her)-6 ( )]TJ 0.007 Tw -29.739 -1.37 Td [(s)-2 (l)2.6 (i)2.6 (g)-11.2 (ht)-6.6 (l)2.6 (y)8.8 ( bel)2.7 (ow)13.5 ( or)-5.9 ( s)-2 (l)2.6 (i)2.6 (g)-11.2 (ht)-6.6 (l)2.6 (y)8.9 ( )11.3 (abov)8.9 (e t)-6.7 (he )]TJ -0.005 Tc 0.01 Tw [(lo)-3.3 (w)10.5 (e)-3.4 (r)-9 ( lim)-8.9 (it)-9.6 ( o)]TJ -0.002 Tc -0.004 Tw 20.598 0 Td [(f)-6.6 ( t)4.3 (he )]TJ -0.013 Tc 0.007 Tw 2.217 0 Td [(r)-17 (ef)-17.6 (e)-11.4 (r)-17 (e)-11.3 (n)-11.4 (c)-13 (e )-10.6 (r)-17 (a)-11.3 (ng)-22.2 (e.)-17.6 ( T)-21.5 (h)-11.4 (e )]TJ -0.002 Tc 11.739 41.804 Td [(r)-6 (i)2.7 (s)-2 (k)-2 ( and)10.5 ( bene)10.6 (f)-17.5 (i)2.6 (t)4.3 ( o)10.5 (f)-6.6 ( )11.2 (T)-10.5 (S)1.9 (H)]TJ 0 Tc 0 Tw 10.141 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(s)8.9 (uppr)-5.9 (es)-2 (s)-2 (i)2.6 (v)8.9 (e t)-6.6 (her)-6 (apy)8.9 ( )11.3 (m)-6 (us)-1.9 (t)4.2 ( be bal)2.6 (anc)-2 (ed)10.5 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( eac)-2 (h)10.5 ( )]TJ -10.478 -1.38 Td [(i)2.6 (ndi)-8.2 (v)8.8 (i)2.6 (dual)2.6 ( pat)-6.6 (i)2.6 (ent)-6.6 ( bec)-2 (aus)8.9 (e o)10.6 (f)-6.7 ( t)-6.5 (he)10.5 ( pot)-6.6 (en)10.5 (t)-6.6 (i)2.6 (al)2.7 ( t)-6.7 (ox)8.9 (i)2.6 (c)-2 (i)2.6 (t)-6.6 (i)2.6 (es)-2 ( )0.5 (as)-2 (s)-2 (oc)-2 (i)2.7 (at)-6.6 (ed)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ -0.004 Tc 0.004 Tw 0 -1.37 Td [(T)-12.6 (SH)]TJ 0 Tc 0 Tw 2 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(s)-2 (upp)10.5 (r)-5.9 (es)-2 (s)-2 (i)2.6 (v)8.9 (e dos)-2 (es)-2 ( )11.3 (o)10.5 (f)-17.5 ( l)2.6 (ev)8.9 (ot)-6.6 (hy)8.8 (r)-5.9 (ox)8.9 (i)2.6 (ne,)-6.6 ( i)2.6 (nc)-2 (l)2.6 (udi)2.6 (n)-11.2 (g c)-2 (ar)-6 (di)2.6 (ac)8.9 ( )]TJ -2.337 -1.38 Td [(t)-6.6 (ac)-2.1 (hy)8.9 (ar)-5.9 (r)-6 (hy)8.8 (t)-6.6 (hm)-6 (i)2.6 (as)8.9 ( \()-6 (es)-1.9 (pec)-2 (i)13.5 (al)2.6 (l)-8.3 (y)8.9 ( i)]TJ 13.065 0 Td [(n t)-6.6 (he el)2.6 (der)-6 (l)2.7 (y)8.8 (\))-5.9 (,)4.2 ( bone )11.3 (dem)-5.9 (i)2.6 (ner)-6 (al)2.6 (i)2.6 (z)8.9 (at)-6.6 (i)2.6 (on )]TJ -13.065 -1.37 Td [(\()-6 (par)5 (t)-6.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 (l)2.6 (y)8.9 ( i)2.6 (n pos)-2 (t)]TJ 0 Tc 0 Tw 8.37 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(m)-6 (en)10.5 (opaus)-2 (al)2.6 ( w)13.5 (om)-5.9 (en\))-6 (,)-6.6 ( and)10.5 ( )11.3 (f)-6.6 (r)-6 (a)10.6 (nk)-2 ( s)-2 (y)8.9 (m)-6 (pt)-6.6 (o)10.5 (m)-6 (s)8.9 ( o)10.5 (f)-6.6 ( )]TJ 0.002 Tw -8.696 -1.38 Td [(t)-6.6 (hy)8.8 (r)-5.9 (ot)-6.6 (ox)8.8 (i)2.6 (c)-2 (os)-2 (i)2.6 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 474.72 441.96 Tm [(3,)-1.9 (29)-17 (3)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 492.12 438 Tm ( )Tj 0.283 0 Td (A)Tj -0.002 Tc 0.007 Tw 0.663 0 Td [(n adeq)-11.2 (ua)10.6 (t)-6.7 (e dai)2.6 (l)2.6 (y)8.9 ( i)2.6 (nt)-6.6 (ak)-12.9 (e)10.6 ( o)10.5 (f)-6.6 ( c)-2 (al)13.5 (c)-2 (i)2.6 (um)-6 ( \()-6 (120)10.5 (0 )11.3 (m)4.9 (g)-11.2 (/)-6.6 (d)10.5 (\))-5.9 ( and)10.5 ( )]TJ -8.837 -1.37 Td [(v)8.9 (i)2.6 (t)-6.6 (am)-5.9 (i)2.6 (n D)2.6 ( \()-5.9 (1000)10.6 ( uni)2.6 (t)-6.6 (s)-2 (/)-6.6 (d)10.5 (\))]TJ 0 Tc 0 Tw 10.533 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)13.5 (s)-2 ( r)-6 (ec)-2 (o)10.5 (m)4.9 (m)-6 (ended )11.3 (f)-6.6 (or)4.9 ( p)]TJ [(at)-6.7 (i)2.7 (e)10.5 (nt)-6.6 (s)-2 ( w)13.5 (hos)-2 (e )11.2 (T)-10.5 (S)1.9 (H)2.6 ( l)2.6 (ev)8.9 (el)2.6 (s)-2 ( )]TJ -10.815 -1.38 Td [(ar)-6 (e )0.5 (c)-2.1 (h)10.6 (r)-6 (oni)2.6 (c)-2 (al)2.6 (l)2.6 (y)8.9 ( s)-2 (uppr)-5.9 (es)-2 (s)8.9 (ed.)]TJ 0 Tc 0 Tw 12.13 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 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For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 787 0 obj 245 endobj %% Contents for page 84 %% Original object ID: 168 0 788 0 obj << /Length 789 0 R >> stream q endstream endobj 789 0 obj 2 endobj %% Contents for page 84 %% Original object ID: 11416 0 790 0 obj << /Length 791 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 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(A)1.9 (I)-6.6 ( al)2.6 (one i)2.6 (n)10.6 ( c)-2 (om)-5.9 (pa)10.5 (r)4.9 (abl)2.6 (e pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( t)4.3 (r)-6 (eat)-6.6 (ed)10.6 ( w)13.5 (i)2.6 (t)-6.6 (h R)2.6 (A)2 (I)-6.6 ( a)10.5 (f)-6.6 (t)-6.6 (e)10.5 (r)-6 ( s)8.9 (ur)5 (g)-11.3 (er)-5.9 (y)8.8 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 357.48 279.12 Tm (303)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 369 275.16 Tm ( )Tj -0.002 Tc 0.007 Tw -31.293 -1.37 Td [(A)2 (not)-6.7 (her)-6 ( )11.3 (s)-2 (t)-6.6 (udy)8.8 ( )11.3 (f)-17.5 (ound)10.5 ( )11.3 (t)-6.6 (hat)4.2 ( r)-5.9 (ec)-2 (u)10.6 (r)-6 (r)-6 (enc)-2 (e)10.6 (s)-2 ( di)2.6 (d no)10.6 (t)-6.6 ( o)10.5 (c)-2 (c)8.8 (ur)-6 ( i)2.6 (n pa)10.6 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( )0.5 (at)4.3 ( hi)2.6 (g)-11.2 (h)10.5 ( r)-5.9 (i)2.6 (s)8.9 (k)-2.1 ( )]TJ 0 -1.37 Td [(w)13.5 (ho r)-6 (ec)-2 (ei)2.6 (v)8.9 (ed E)2 (B)1.9 (R)2.7 (T)-10.6 (,)-6.6 ( bu)10.5 (t)-6.6 ( )11.3 (r)-6 (ec)-2 (ur)4.9 (r)-6 (enc)-2 (es)8.8 ( di)2.6 (d )0.5 (oc)-2 (c)-2 (u)10.5 (r)-5.9 ( i)2.6 (n )11.3 (t)-6.6 (hos)-2 (e )0.5 (w)13.4 (ho di)2.6 (d not)4.2 ( )]TJ 0.002 Tw 0 -1.38 Td [(r)-6 (ec)-2 (ei)2.7 (v)8.8 (e )]TJ 0.007 Tw 3.489 0 Td [(E)2 (B)1.9 (R)2.6 (T)-10.6 (.)4.3 ( H)2.6 (ow)13.5 (e)-11.3 (v)8.9 (er)-6 (,)-6.6 ( t)-6.6 (he)10.6 ( s)-2 (t)-6.6 (udy)8.8 ( w)13.5 (as)-2 ( not)4.2 ( pow)13.5 (er)-6 (ed t)-6.6 (o)10.5 ( det)-6.6 (ec)8.8 (t)-6.6 ( a)10.6 ( s)8.8 (t)-6.6 (at)-6.6 (i)2.6 (s)8.8 (t)-6.6 (i)2.6 (c)-2 (al)2.6 ( )]TJ 0.002 Tw -3.489 -1.37 Td [(s)-2 (i)2.6 (g)-11.2 (ni)13.5 (f)-17.4 (i)2.6 (c)-2 (anc)-2 (e)10.5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 84.12 218.52 Tm (304)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 95.64 214.56 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(O)-6.6 (t)-6.6 (her)4.9 ( da)10.5 (t)4.2 (a )11.3 (f)-6.6 (r)-6 (om)5 ( s)-2 (i)2.6 (n)10.5 (g)-11.2 (l)2.6 (e i)2.7 (ns)-2 (t)-6.6 (i)2.6 (t)-6.6 (u)10.5 (t)-6.6 (i)2.6 (ons)-2 ( )11.3 (al)2.6 (s)-2 (o s)-2 (how)13.5 ( t)-6.6 (hat)-6.6 ( )11.3 (adj)-8.3 (uv)8.8 (ant)-6.6 ( )]TJ -0.005 Tc 0.01 Tw -6.815 -1.38 Td [(E)-1 (B)-1.1 (RT)-13.6 ( y)5.9 (ie)-3.4 (ld)-3.3 (s)-5 ( lo)-3.4 (n)-3.3 (g)]TJ 0 Tc 0 Tw 7.652 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(t)-6.6 (er)5 (m)4.9 ( c)8.8 (ont)-6.6 (r)-5.9 (ol)2.7 ( o)10.6 (f)-6.7 ( l)2.7 (oc)-2 (o)10.5 (r)-5.9 (e)10.5 (g)-11.2 (i)2.6 (onal)2.6 ( di)2.6 (s)-2 (eas)-2 (e.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 288.36 203.28 Tm (305)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 1.983 0 Td [(3)-17 (07)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 313.8 199.32 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(S)2 (t)-6.7 (udi)2.7 (es)-2 ( )]TJ -0.004 Tw -26.576 -1.37 Td [(s)-2 (ugg)-11.2 (es)8.9 (t)-6.6 ( t)-6.6 (ha)10.5 (t)-6.6 ( )-10.6 (i)2.6 (nt)-6.6 (ens)-2 (i)13.5 (t)-6.6 (y)]TJ 0 Tc 0 Tw 9.359 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(m)-6 (o)10.6 (dul)2.6 (at)-6.6 (ed r)-5.9 (adi)2.6 (at)-6.6 (i)2.6 (on)10.5 ( t)-6.6 (he)10.5 (r)-6 (apy)8.9 ( \()4.9 (I)-6.6 (M)15.8 (R)2.6 (T)-10.6 (\))-5.9 ( i)2.6 (s)-2 ( s)-2 (a)10.5 (f)-6.6 (e)10.5 (,)-6.6 ( )]TJ -9.696 -1.38 Td [(e)10.5 (f)-6.6 (f)-17.5 (ec)8.9 (t)-6.6 (i)2.6 (v)8.8 (e,)-6.6 ( and l)2.6 (es)-2 (s)8.9 ( m)-6 (o)10.5 (r)-5.9 (bi)13.5 (d i)2.7 (n pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )11.3 (c)-2 (anc)-2 (er)-5.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 299.4 172.92 Tm [(305,)-1.8 (30)-17 (8)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 324.48 168.96 Tm ( )Tj /TT1 1 Tf 0.283 0 Td ( )Tj EMC /H3 <>BDC /TT2 1 Tf 0.01 Tc -0.01 Tw 9.96 -0 0 9.96 23.52 143.64 Tm [(E)2.3 (xt)-6.4 (er)1.3 (n)-5.5 (al)]TJ 0 Tc 0 Tw 4.036 0 Td (-)Tj 0.01 Tc 0.001 Tw 0.349 0 Td [(B)-3 (eam)-4.6 ( R)-2.9 (T)-5.5 ( an)-5.5 (d)]TJ 0 Tc 0 Tw 6.53 0 Td ( )Tj 0.01 Tc 0.001 Tw 0.289 0 Td [(S)2.3 (u)-5.5 (r)1.4 (g)-5.5 (i)-1.2 (cal)-1.2 ( E)2.3 (xci)-1.1 (si)-1.2 (o)-5.5 (n)-5.5 ( o)-5.5 (f)-6.4 ( )-12.2 (M)23.7 (et)-6.4 (as)-12.3 (t)-6.4 (ases )]TJ 0 Tc 0 Tw ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 128.28 Tm [(S)2 (ur)-5.9 (g)-11.3 (i)2.7 (c)-2.1 (al)2.6 ( ex)8.8 (c)-2 (i)2.7 (s)-2 (i)2.5 (on,)-6.6 ( E)2 (B)2 (R)13.4 (T)-10.5 (,)4.2 ( s)-2 (t)-6.6 (e)10.5 (r)-5.9 (eot)-6.6 (ac)8.9 (t)-6.6 (i)2.6 (c)-2 ( body)8.9 ( )11.2 (r)-5.9 (adi)2.6 (at)-6.6 (i)2.6 (on t)-6.6 (he)10.5 (r)-5.9 (apy)8.8 ( \()-5.9 (S)1.9 (B)2 (R)2.6 (T\))-6 (,)4.3 ( or)4.9 ( )]TJ 0 -1.37 Td [(ot)-6.7 (her)5 ( l)2.6 (oc)-2 (al)2.6 ( t)-6.6 (he)10.6 (r)-6 (api)2.6 (es)-2 ( c)-2 (an)10.5 ( be c)-2 (ons)-2 (i)2.6 (de)10.5 (r)-5.9 (ed )11.3 (f)-6.7 (or)4.9 ( s)-2 (y)8.9 (m)-6 (pt)4.2 (om)-6 (at)-6.6 (i)2.6 (c)8.9 ( i)2.6 (s)-2 (ol)2.6 (at)-6.6 (ed s)8.9 (k)-12.9 (el)2.7 (e)10.5 (t)-6.6 (al)2.6 ( )]TJ 0 -1.38 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 ( or)5 ( t)-6.6 (ho)10.5 (s)-2 (e )11.2 (t)-6.6 (hat)4.3 ( ar)-5.9 (e)10.5 ( as)-2 (y)8.8 (m)-5.9 (pt)-6.6 (o)10.6 (m)-6 (at)-6.6 (i)2.6 (c)8.9 ( i)2.6 (n w)13.5 (ei)-8.3 (g)-11.2 (h)10.6 (t)]TJ 0 Tc 0 Tw 23.272 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(bea)10.5 (r)-5.9 (i)2.6 (ng s)-2 (i)2.6 (t)-6.6 (es)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 349.56 101.88 Tm [(309,)-1.8 (3)-17 (10)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 374.64 97.92 Tm ( )Tj -0.002 Tc 0.007 Tw -31.804 -1.37 Td [(B)2 (r)-6 (ai)2.6 (n m)-6 (e)10.6 (t)-6.6 (as)-2 (t)-6.6 (a)10.5 (s)-2 (es)-2 ( pos)8.9 (e a)10.6 ( s)-2 (pec)-2 (i)2.7 (al)2.6 ( pr)-6 (obl)2.6 (em)4.9 (,)4.3 ( bec)-2 (a)]TJ 0.002 Tw [(us)8.8 (e )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 275.52 86.76 Tm (131)Tj -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 287.04 82.8 Tm [(I)-6.6 ( )-10.6 (t)-6.6 (her)-6 (apy)8.9 ( m)-6 (ay)8.8 ( )]TJ 0.007 Tw -23.87 -1.38 Td [(i)2.6 (nduc)-2 (e c)-2 (er)-6 (eb)10.5 (r)-6 (al)2.6 ( edem)-6 (a)10.5 (.)-6.6 ( )11.3 (N)2.6 (eur)-6 (os)-2 (ur)4.9 (g)-11.3 (i)2.7 (c)-2 (al)2.6 ( r)-5.9 (e)10.5 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (on)10.5 ( )11.3 (c)-2 (an be c)-2 (on)10.6 (s)-2 (i)2.6 (der)-6 (ed )11.3 (f)-6.6 (or)5 ( )]TJ 0 -1.37 Td [(br)-6 (ai)2.7 (n m)-5.9 (e)10.5 (t)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)-2 (.)4.2 ( )0.5 (For)4.9 ( s)-2 (o)10.6 (l)2.6 (i)2.6 (t)-6.6 (ar)-6 (y)8.9 ( br)-6 (ai)2.6 (n l)2.6 (es)-2 (i)2.6 (ons)-2 (,)-6.6 ( ei)13.5 (t)-6.6 (her)5 ( neur)-6 (os)-2 (u)10.5 (r)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( r)-6 (es)-2 (e)10.5 (c)-2 (t)-6.6 (i)2.6 (on )]TJ 34.554 41.804 Td [(or)-6 ( s)8.9 (t)-6.6 (er)-5.9 (eo)10.5 (t)-6.6 (ac)-2 (t)-6.6 (i)2.6 (c)8.9 ( r)-6 (adi)2.6 (os)-2 (u)10.5 (r)4.9 (ger)-5.9 (y)8.8 ( i)2.6 (s)-2 ( pr)-6 (e)10.5 (f)-6.6 (er)-6 (r)5 (ed ov)8.9 (er)-5.9 ( w)13.5 (hol)2.6 (e br)-6 (ai)2.6 (n r)-5.9 (adi)2.6 (a)10.5 (t)-6.6 (i)2.6 (on)]TJ 0 Tc 0 Tw (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 729.12 517.92 Tm [(311,)-1.8 (3)-17 (12)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 754.2 513.96 Tm ( )Tj -0.002 Tc 0.007 Tw -31.63 -1.38 Td [(O)-6.6 (nc)-2 (e b)10.5 (r)-5.9 (ai)2.6 (n)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 5.152 0 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 ( a)10.5 (r)-5.9 (e di)2.6 (a)10.5 (g)-11.2 (nos)-2 (ed,)4.3 ( di)2.6 (s)-2 (eas)-2 (e)]TJ 0 Tc 0 Tw (-)Tj -0.011 Tc 0.016 Tw 16.011 0 Td [(sp)-9.4 (e)-9.3 (c)-11 (i)-6.4 (f)-26.5 (i)-6.4 (c m)-15 (o)1.5 (r)-14.9 (t)-15.6 (a)-9.4 (l)-6.4 (i)-6.4 (t)-15.6 (y i)-6.4 (s)-11 ( ve)-9.4 (r)-15 (y )]TJ -0.002 Tc 0.007 Tw -21.163 -1.37 Td [(hi)2.6 (g)-11.3 (h )11.3 (\()-6 (67%)6.6 (\))-6 (,)4.3 ( w)13.5 (i)2.6 (t)-6.6 (h a r)-6 (epo)10.5 (r)-5.9 (t)4.2 (ed )0.5 (m)-6 (edi)2.6 (an )11.3 (s)-2 (ur)-5.9 (v)8.9 (i)2.6 (v)8.8 (al)2.6 ( of)-17.4 ( 12)10.5 (.)4.3 (4 m)-5.9 (on)10.6 (t)-6.6 (hs)-2 ( i)2.6 (n)10.5 ( one )]TJ 0.004 Tc -0.004 Tw 0 -1.38 Td (re)Tj -0.002 Tc 0.007 Tw 0.891 0 Td [(t)-6.6 (r)4.9 (os)-2 (pec)-2 (t)-6.6 (i)2.6 (v)8.8 (e s)-2 (t)-6.6 (udy)8.9 (.)4.2 ( S)2 (ur)-5.9 (v)8.8 (i)2.6 (v)8.9 (a)-11.2 (l)2.6 ( w)13.5 (as)-2.1 ( )0.5 (s)-2 (i)2.6 (g)-11.3 (ni)2.6 (f)-17.5 (i)2.6 (c)-2 (an)10.5 (t)-6.6 (l)2.6 (y)8.9 ( i)2.6 (m)-6 (pr)-6 (ov)8.9 (ed by)8.9 ( s)-2 (ur)5 (g)-11.3 (i)2.6 (c)-2 (al)2.6 ( )]TJ -0.004 Tw -0.891 -1.37 Td [(r)-6 (es)-2 (ec)-2 (t)-6.6 (i)2.7 (on)10.5 ( )-10.6 (o)10.5 (f)-6.6 ( )-10.6 (one )-10.6 (o)10.5 (r)-6 ( m)-5.9 (or)-5.9 (e)10.5 ( t)-6.6 (um)-6 (o)10.6 (r)-6 ( f)-6.6 (oc)-2 (i)2.6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 578.76 457.2 Tm (313)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 590.28 453.24 Tm ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(M)15.8 (os)-2 (t)-6.6 ( )-10.6 (r)-5.9 (ec)-2 (ur)4.9 (r)4.9 (ent)-6.6 ( t)-6.6 (um)-6 (o)10.6 (r)-6 (s)-2 ( r)-6 (es)-2 (pond)10.5 ( )-10.6 (w)13.5 (el)2.6 (l)2.6 ( )]TJ 0.007 Tw -17.065 -1.38 Td [(t)-6.6 (o s)-2 (u)10.6 (r)4.9 (g)-11.2 (er)-6 (y)8.9 (;)-6.6 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 460.2 441.96 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 471.72 438 Tm [(I)-6.6 ( )11.3 (t)-6.7 (her)-6 (apy)8.9 (;)-6.6 ( )11.2 (E)2 (B)1.9 (R)2.7 (T)-10.6 (,)4.3 ( S)2 (B)2 (R)2.6 (T,)-6.6 ( o)10.5 (r)-6 ( )11.3 (I)-6.6 (M)15.8 (R)2.6 (T)-10.6 (;)-6.6 ( )11.3 (or)-5.9 ( o)10.5 (t)-6.6 (her)4.9 ( l)2.6 (oc)-2 (al)2.6 ( t)-6.6 (he)10.5 (r)-6 (api)2.6 (es)-2 ( )]TJ -6.043 -1.37 Td [(s)-2 (uc)-2 (h as)8.8 ( et)-6.6 (hanol)2.6 ( abl)2.6 (a)]TJ 9.141 0 Td [(t)-6.6 (i)2.6 (on,)4.3 ( c)-2 (r)-6 (y)8.9 (oabl)2.7 (at)-6.6 (i)2.6 (on,)-6.6 ( o)10.5 (r)-5.9 ( )11.2 (r)-5.9 (adi)2.6 (o)10.5 (f)-17.5 (r)-5.9 (e)10.5 (q)-11.2 (uenc)-2 (y)8.9 ( abl)2.6 (at)-6.6 (i)2.6 (on )]TJ -0.005 Tc 0.005 Tw -9.141 -1.38 Td [(\()-9 (RF)-2.7 (A)-1 (\))]TJ 0 Tc 0 Tw 2.663 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 437.52 411.6 Tm [(3,)-1.9 (314)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 454.8 407.64 Tm ( )Tj 0.283 0 Td ( )Tj EMC /H3 <>BDC /TT2 1 Tf 0.01 Tc -0.01 Tw 9.96 -0 0 9.96 405 382.32 Tm [(S)2.3 (yst)-6.4 (em)-4.6 (i)-1.2 (c)]TJ 0 Tc 0 Tw ( )Tj 0.016 Tc -0.016 Tw 4.771 0 Td [(T)0.5 (h)0.5 (e)5.7 (r)7.5 (a)5.7 (p)0.5 (y)]TJ 0 Tc 0 Tw 3.988 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.011 Tc 0.011 Tw 11.04 -0 0 11.04 405 366.96 Tm [(S)-7 (ys)-11 (t)-15.6 (e)-9.3 (m)-15 (i)-6.4 (c)]TJ 0 Tc 0 Tw 4.043 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(t)-6.6 (he)10.5 (r)-6 (apy)8.9 ( c)-2 (an be)10.6 ( c)-2 (ons)-2 (i)2.6 (der)-6 (ed)10.5 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )11.2 (t)-6.6 (um)-6 (o)10.6 (r)-6 (s)-2 ( )11.3 (t)-6.7 (h)10.6 (at)-6.6 ( a)10.5 (r)-5.9 (e no)10.5 (t)-6.6 ( s)-2 (u)10.5 (r)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 (l)2.6 (y)8.9 ( )]TJ -4.326 -1.37 Td [(r)-6 (es)-2 (ec)-1.9 (t)-6.7 (abl)2.7 (e)10.5 (;)-6.6 ( a)10.5 (r)-6 (e no)10.6 (t)-6.6 ( )11.2 (r)-5.9 (es)-2 (po)10.5 (ns)-2 (i)2.7 (v)8.8 (e t)-6.6 (o )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 567.72 355.8 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 579.24 351.84 Tm [(I)-6.6 (;)-6.6 ( ar)-5.9 (e)10.5 ( not)4.3 ( a)10.5 (m)-6 (e)10.6 (nabl)2.6 (e t)-6.6 (o E)2 (B)1.9 (R)13.5 (T)-10.5 ( )]TJ -15.783 -1.38 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 (,)4.3 ( S)1.9 (B)2 (R)2.6 (T,)-6.6 ( )11.3 (I)-6.6 (M)15.7 (R)2.6 (T)-10.5 (,)-6.6 ( )11.2 (or)-6 ( o)10.6 (t)-6.6 (her)4.9 ( l)2.6 (oc)-2 (al)2.6 ( t)-6.6 (he)10.6 (r)-6 (api)2.6 (es)-2 (;)4.2 ( )11.3 (and hav)8.8 (e c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 (l)-8.2 (y)8.9 ( )]TJ 0 -1.37 Td [(s)-2 (i)2.6 (g)-11.2 (ni)13.5 (f)-17.4 (i)2.6 (c)-2 (ant)4.2 ( s)8.9 (t)-6.6 (r)-6 (uc)8.8 (t)-6.6 (ur)-6 (al)2.6 ( di)2.6 (s)-2 (e)10.5 (as)-2.1 (e pr)-5.9 (o)10.5 (gr)-6 (es)-2 (s)-2 (i)2.6 (on )]TJ [(du)10.6 (r)-6 (i)2.6 (ng t)4.3 (he l)2.6 (as)-2 (t)-6.6 ( 6)10.6 ( )11.2 (t)-6.6 (o 12)10.5 ( m)-5.9 (on)10.5 (t)-6.6 (hs)8.9 (.)-6.6 ( )]TJ 0 -1.38 Td [(A)2 (m)-6 (on)10.6 (g)-11.2 ( 49)10.5 ( pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h )11.3 (m)-6 (et)-6.6 (as)8.9 (t)-6.6 (at)-6.6 (i)2.6 (c)8.8 ( di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)5 (a w)13.5 (ho )]TJ 0 -1.37 Td [(w)13.5 (er)-5.9 (e t)-6.6 (r)-5.9 (eat)-6.6 (ed)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h 5 c)-2 (he)10.5 (m)-6 (ot)-6.6 (he)10.6 (r)-6 (apy)8.9 ( pr)-5.9 (ot)-6.6 (o)10.5 (c)-2 (ol)2.6 (s)-2 (,)-6.6 ( )11.3 (onl)2.6 (y)8.8 ( )0.5 (2 \()-5.9 (3%)6.6 (\))-6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( )0.5 (had )]TJ 0 -1.38 Td [(obj)-8.3 (ec)-2 (t)-6.6 (i)2.6 (v)8.9 (e r)-5.9 (es)-2 (pon)10.6 (s)-2 (es)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 505.44 279.84 Tm (315)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 516.96 275.88 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)4.3 (n a )11.2 (r)-5.9 (ev)8.9 (i)2.6 (e)-11.2 (w)13.5 ( of)-6.6 ( publ)2.6 (i)2.6 (s)-2 (hed )0.5 (s)8.8 (er)-6 (i)2.6 (es)-2 (,)-6.6 ( 38)10.5 (%)-4.3 ( o)10.6 (f)-6.7 ( p)10.6 (at)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( )]TJ -10.424 -1.37 Td [(had a )11.3 (r)-6 (es)-2 (pons)-2 (e)10.6 ( \()-6 (de)10.6 (f)-17.5 (i)2.6 (ned)10.5 ( )11.3 (as)-2 ( a dec)8.9 (r)-6 (eas)-2 (e)10.6 ( i)2.6 (n t)-6.6 (u)10.5 (m)-5.9 (o)10.5 (r)-6 ( )11.3 (m)-6 (as)-2 (s)-2 (\))4.9 ( )11.3 (t)-6.6 (o dox)8.9 (or)-6 (ubi)2.6 (c)-2 (i)2.6 (n.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 746.28 264.72 Tm (316)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 757.8 260.76 Tm ( )Tj -0.002 Tc 0.007 Tw -31.957 -1.38 Td [(C)2.6 (om)-6 (bi)2.6 (nat)-6.6 (i)2.6 (on c)-2 (he)10.6 (m)-6 (ot)-6.7 (he)10.5 (r)4.9 (apy)8.8 ( i)2.6 (s)-2 ( not)-6.6 ( c)-2 (l)2.6 (ear)-5.9 (l)2.6 (y)8.9 ( s)-2 (uper)-5.9 (i)2.6 (o)10.5 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0.004 Tw 6.96 -0 0 6.96 636.96 82.56 Tm (356)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 1.983 0 Td [(35)-17 (9)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 662.4 78.6 Tm ( )Tj 0.283 0 Td ( )Tj EMC ET endstream endobj 791 0 obj 28364 endobj %% Contents for page 84 %% Original object ID: 169 0 792 0 obj << /Length 793 0 R >> stream Q q BT /Xi82 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 793 0 obj 245 endobj %% Contents for page 85 %% Original object ID: 170 0 794 0 obj << /Length 795 0 R >> stream q endstream endobj 795 0 obj 2 endobj %% Contents for page 85 %% Original object ID: 11417 0 796 0 obj << /Length 797 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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(api)2.6 (l)2.6 (l)2.6 (ar)5 (y)8.8 ( [)-6.6 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d])4.3 ( C)2.6 (ar)-5.9 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (\))-6 (.)4.3 ( )]TJ -5.098 -1.37 Td [(V)2 (andet)-6.6 (ani)2.6 (b and c)-2 (ab)]TJ -0.004 Tw [(oz)8.8 (an)10.5 (t)-6.6 (i)2.6 (ni)2.7 (b,)-6.6 ( )-10.6 (or)-6 (al)13.4 ( k)-12.9 (i)2.6 (nas)-2 (e )-10.6 (i)2.6 (nhi)2.6 (bi)2.6 (t)-6.6 (or)4.9 (s)-2 (,)-6.6 ( )-10.6 (a)10.6 (r)-6 (e r)-5.9 (ec)-2 (o)10.5 (m)-5.9 (m)-6 (ended)10.6 ( f)-17.5 (o)10.6 (r)-6 ( )]TJ 0.007 Tw 0 -1.38 Td [(t)-6.6 (he )11.3 (t)-6.6 (r)-6 (ea)10.6 (t)-6.6 (m)-6 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (m)-6 (edul)2.6 (l)2.6 (ar)4.9 (y)8.9 ( c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a i)2.6 (n)10.6 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( )11.3 (w)2.6 (i)2.6 (t)-6.6 (h unr)-6 (es)-2 (ec)8.9 (t)-6.6 (abl)2.6 (e l)2.7 (oc)-2 (al)2.6 (l)2.6 (y)8.9 ( )]TJ -0.004 Tw 0 -1.37 Td [(adv)8.9 (anc)-2 (ed )-10.6 (or)-5.9 ( m)-6 (et)-6.6 (as)8.9 (t)-6.7 (at)-6.6 (i)2.6 (c)8.9 ( di)2.6 (s)-2 (eas)-2 (e )-10.6 (\()-6 (s)-2 (ee)10.5 ( )]TJ /TT2 1 Tf 16.511 0 Td [(M)4.9 (edul)2.6 (l)2.6 (ar)-5.9 (y)-2 ( Thy)-2 (r)-5.9 (oi)2.6 (d )-10.6 (C)2.6 (ar)-5.9 (c)-2 (i)2.6 (no)10.6 (m)-6 (a)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.005 Tc -0.001 Tw 13.293 0 Td [(in)-3.3 ( t)-9.6 (h)-3.4 (is)-5 ( )]TJ 0 Tc 0 Tw -29.804 -1.38 Td [(D)4.6 (i)4.6 (scu)1.7 (ssi)4.6 (o)1.6 (n)]TJ 4.815 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(and t)-6.7 (he)10.5 ( N)2.6 (C)2.7 (C)2.6 (N)2.6 ( G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2.1 ( )11.3 (f)-17.5 (o)10.6 (r)-6 ( M)15.8 (edul)2.7 (l)2.6 (a)-11.3 (r)-5.9 (y)8.9 ( [)4.2 (T)-10.5 (hy)8.9 (r)]TJ 20.054 0 Td [(oi)2.6 (d])-6.6 ( C)2.6 (ar)4.9 (c)-2 (i)2.6 (nom)-6 (a\))4.9 (.)-6.6 ( )]TJ -25.152 -1.37 Td [(S)2 (ev)8.9 (er)-5.9 (e or)-6 ( )11.3 (f)-6.6 (at)-6.6 (al)2.6 ( s)-2 (i)2.6 (de)10.6 ( e)10.5 (f)-6.6 (f)-6.6 (ec)8.9 (t)-6.6 (s)-2 ( )11.3 (f)-6.6 (r)-6 (o)10.5 (m)-5.9 ( )11.2 (k)-12.8 (i)2.6 (nas)-2 (e)10.5 ( i)2.6 (nhi)2.6 (bi)2.6 (t)-6.6 (or)-5.9 (s)8.8 ( i)2.7 (nc)-2 (l)2.6 (ude bl)2.6 (eedi)2.6 (ng)-11.3 (,)4.3 ( )]TJ 0 -1.38 Td [(hy)8.8 (per)-5.9 (t)-6.6 (ens)-2 (i)2.6 (on,)-6.6 ( s)8.9 (t)-6.7 (r)-5.9 (o)10.5 (k)-12.9 (e)10.6 (,)4.2 ( an)10.5 (d l)2.7 (i)2.6 (v)8.8 (er)-6 ( t)-6.6 (ox)8.9 (i)2.5 (c)-1.9 (i)2.6 (t)-6.6 (y)8.8 (;)-6.6 ( how)13.5 (e)-11.2 (v)8.9 (er)-5.9 (,)-6.7 ( )0.5 (m)-6 (os)-2 (t)4.3 ( s)-2 (i)2.6 (de e)10.5 (f)-6.6 (f)-6.6 (ec)8.8 (t)-6.6 (s)8.9 ( c)-2 (an be)10.5 ( )]TJ 0 -1.37 Td [(m)-6 (ana)10.6 (g)-11.2 (ed and)10.5 ( ar)-5.9 (e)10.5 ( r)-6 (ev)8.9 (er)-5.9 (s)-2 (i)13.4 (bl)2.6 (e w)13.5 (i)2.5 (t)-6.5 (h di)2.6 (s)-2 (c)-2 (ont)-6.6 (i)2.6 (nuat)-6.6 (i)2.6 (on )11.3 (o)10.5 (f)-17.5 ( )11.3 (t)-6.6 (he d)10.5 (r)-5.9 (u)10.5 (g)-11.2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 318.36 335.76 Tm [(328,)-1.8 (32)-17 (9,)-1.9 (3)-16.9 (63)]TJ 0 Tc 0 Tw 5.569 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.328 0 Td [(3)-17 (68)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 371.04 331.8 Tm ( )Tj -0.002 Tc 0.007 Tw -31.478 -1.38 Td [(D)2.6 (os)-2 (e m)-5.9 (odi)13.4 (f)-17.4 (i)2.6 (c)-2 (a)10.5 (t)-6.6 (i)2.6 (ons)-2 ( o)10.5 (f)-6.6 ( )11.3 (k)-12.9 (i)2.6 (n)10.5 (as)-2 (e i)2.6 (nhi)2.6 (bi)2.6 (t)-6.6 (or)-6 (s)-2 ( )]TJ 17.228 0 Td [(m)-6 (ay)8.9 ( be )11.2 (r)-5.9 (e)10.5 (q)-11.2 (ui)2.7 (r)-6 (ed)10.6 (.)-6.6 ( P)]TJ 8.424 0 Td [(az)8.8 (opani)2.7 (b has)-2 ( )]TJ -25.652 -1.37 Td [(been r)-5.9 (epo)10.5 (r)-6 (t)-6.6 (ed)10.5 ( t)-6.6 (o)10.5 ( c)-2 (aus)-2 (e)10.5 ( r)4.9 (ev)8.9 (er)-5.9 (s)-2 (i)2.6 (bl)2.6 (e hy)8.8 (popi)2.6 (g)-11.2 (m)-6 (ent)-6.6 (at)-6.6 (i)13.4 (on.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 280.44 305.4 Tm (369)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 291.96 301.44 Tm ( )Tj 0.283 0 Td ( )Tj EMC /H1 <>BDC /TT1 1 Tf 0.009 Tc 12.96 -0 0 12.96 23.52 273.84 Tm [(Papillar)-9.4 (y)18.7 ( Th)-18.9 (y)18.7 (roid C)-9.8 (arcinoma )]TJ /CS0 cs 0.114 0.106 0.067 scn 0 Tc ( )Tj EMC /H2 <>BDC /CS1 cs 0 scn 0.009 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 255 Tm [(S)2.1 (ur)-4.1 (g)11.3 (i)-6.5 (ca)10.6 (l)-6.5 ( )0.6 (T)11.3 (her)-4.2 (a)10.7 (py)]TJ 0 Tc 0 Tw 8.228 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw -8.228 -1.707 Td [(I)-6.6 (m)-6 (a)10.6 (g)-11.3 (i)2.7 (n)10.5 (g)-11.2 ( i)2.6 (s)8.8 ( per)5 (f)-6.7 (or)4.9 (m)-5.9 (ed)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 9.652 0 Td [(be)10.5 (f)4.2 (or)-6 (e s)-2 (u)10.5 (r)4.9 (g)-11.2 (er)-6 (y)8.9 ( t)-6.6 (o)10.5 ( as)-2 (c)-2 (e)10.6 (r)-6 (t)-6.6 (ai)2.7 (n)10.5 ( t)4.2 (he ex)8.9 (t)-6.6 (ent)-6.6 ( o)10.5 (f)-6.6 ( di)2.6 (s)-2 (eas)-2 (e)10.6 ( and)10.5 ( )]TJ -9.652 -1.37 Td [(t)-6.6 (o ai)2.6 (d i)2.6 (n )11.3 (t)-6.6 (he)10.6 ( s)-2 (ur)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( dec)-2 (i)13.5 (s)-2 (i)2.6 (on)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.13 0 Td [(m)-6 (a)10.6 (k)-12.9 (i)2.6 (n)10.5 (g)-11.2 ( p)10.5 (r)-5.9 (oc)-2 (es)-2 (s)8.9 (.)-6.6 ( A)12.8 ( )11.2 (c)-2 (er)-6 (v)8.9 (i)2.6 (c)-2 (al)2.6 ( ul)2.7 (t)-6.7 (r)-5.9 (as)-2 (ound,)4.2 ( )]TJ -13.13 -1.37 Td [(i)2.6 (nc)-2 (l)2.6 (udi)2.6 (ng)-11.2 ( t)-6.6 (he)10.5 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d and)10.5 ( )11.2 (t)-6.6 (he c)-2 (en)10.5 (t)-6.6 (r)-5.9 (al)2.6 ( &)12.9 ( )]TJ [(l)2.7 (at)-6.6 (e)10.5 (r)-5.9 (al)2.6 ( c)-2 (o)10.6 (m)4.9 (par)-6 (t)4.3 (m)-6 (ent)-6.6 (s)8.9 (,)-6.6 ( i)2.6 (s)8.9 ( t)-6.7 (he)10.5 ( )]TJ -0.005 Tc 0.005 Tw 0 -1.38 Td [(p)-3.3 (r)-9 (in)-3.4 (c)-5 (ip)]TJ -0.002 Tc 0.002 Tw 2.935 0 Td (al)Tj 0 Tc 0 Tw 0.772 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (m)-5.9 (ag)-11.2 (i)2.6 (n)10.5 (g m)-6 (odal)2.6 (i)2.6 (t)4.3 (y)8.8 ( t)-6.6 (hat)-6.6 ( i)2.6 (s)8.9 ( r)-6 (ec)-2 (o)10.5 (m)4.9 (m)-5.9 (ended.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 259.08 194.64 Tm (370)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 270.6 190.68 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)-6.6 (n one)10.6 ( r)-6 (epo)10.5 (r)-5.9 (t)4.2 (,)-6.6 ( c)-2 (e)10.6 (r)-6 (v)8.9 (i)2.6 (c)-2 (al)2.5 ( )]TJ -22.663 -1.37 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2.1 (ound pe)10.5 (r)5 (f)-17.5 (o)10.5 (r)4.9 (m)-6 (ed be)10.5 (f)-6.6 (or)-6 (e)10.5 ( pr)-6 (i)2.7 (m)-6 (a)10.5 (r)-5.9 (y)8.8 ( s)-2 (ur)4.9 (g)-11.2 (e)10.5 (r)-5.9 (y)8.8 ( )11.3 (f)-17.5 (or)4.9 ( )11.3 (new)2.6 (l)2.6 (y)8.8 ( di)2.6 (ag)-11.2 (nos)-2 (ed t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.38 Td [(c)-2 (anc)-2 (er)-6 ( i)2.6 (den)10.5 (t)-6.6 (i)13.5 (f)-17.5 (i)2.6 (ed )11.3 (m)-5.9 (et)-6.6 (as)8.8 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( s)-2 (i)2.7 (t)-6.7 (es)8.9 ( not)4.2 ( appr)4.9 (ec)-2 (i)2.6 (at)-6.6 (ed )11.3 (on phy)8.9 (s)-2 (i)2.6 (c)-2 (al)2.6 ( ex)8.9 (am)-5.9 (i)2.6 (nat)-6.6 (i)2.6 (on )]TJ 0 -1.37 Td [(i)2.6 (n 20%)-4.3 ( o)10.5 (f)-6.6 ( pa)10.5 (t)-6.6 (i)2.7 (ent)-6.6 (s)8.9 (,)-6.6 ( and)10.5 ( s)8.9 (ur)4.9 (g)-11.3 (i)2.7 (c)-2 (al)2.6 ( s)-2 (t)4.3 (r)-6 (at)-6.6 (e)10.5 (g)-11.2 (y)8.9 ( w)13.5 (as)-2 ( al)2.6 (t)-6.6 (er)4.9 (ed i)2.6 (n 39%)6.5 ( o)10.5 (f)-6.6 ( pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 371.64 149.16 Tm (371)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 383.16 145.2 Tm ( )Tj -32.576 -1.38 Td (S)Tj -0.002 Tc 0.002 Tw 0.663 0 Td [(ur)-6 (g)-11.2 (eon)]TJ 0 Tc 0 Tw 3.109 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(per)4.9 (f)-6.6 (or)4.9 (m)-6 (ed)10.5 ( pr)-6 (eo)10.6 (per)-6 (at)-6.6 (i)2.6 (v)8.8 (e ul)2.6 (t)-6.6 (r)-6 (as)-1.9 (ound)10.5 ( i)]TJ 15.783 0 Td [(dent)4.2 (i)2.6 (f)-17.4 (i)2.6 (ed nonpal)2.6 (pabl)2.6 (e )]TJ -19.891 -1.37 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (at)-6.7 (i)2.7 (c)8.8 ( l)2.6 (y)8.9 (m)-6 (ph nodes)8.8 ( i)2.6 (n 24%)6.6 ( o)10.5 (f)-6.6 ( pat)-6.6 (i)2.6 (ent)4.3 (s)-2.1 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 232.8 118.8 Tm (372)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 244.32 114.84 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)-6.6 (n )11.3 (m)-5.9 (or)-5.9 (e)10.5 ( t)-6.6 (han)10.5 ( 7)]TJ [(00 pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( )]TJ -20.283 -1.38 Td [(w)2.6 (i)2.6 (t)-6.6 (h P)1.9 (T)-10.5 (C)13.4 (,)-6.6 ( p)10.6 (r)-6 (eoper)-6 (a)10.6 (t)-6.6 (i)2.6 (v)8.8 (e ul)2.6 (t)-6.7 (r)-5.9 (as)-2 (ound de)10.5 (t)-6.6 (ec)8.9 (t)-6.7 (ed nonp)10.5 (al)2.6 (pabl)2.6 (e nodal)2.6 ( )]TJ 0 -1.37 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 ( i)2.6 (n 33%)6.6 ( o)10.5 (f)-6.6 ( s)-2 (u)10.5 (bj)-8.3 (ec)-2 (t)4.3 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 175.32 88.44 Tm (373)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 186.84 84.48 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(P)2 (r)-6 (eoper)-5.9 (a)10.5 (t)-6.6 (i)2.6 (v)8.8 (e ul)2.6 (t)-6.6 (r)-6 (as)-2 (ound)10.5 ( )11.3 (f)-17.5 (i)2.7 (ndi)2.6 (n)10.5 (g)-11.2 (s)-2 ( al)13.5 (t)-6.6 (er)-5.9 (ed)10.6 ( )]TJ -15.076 -1.38 Td [(t)-6.6 (he ope)10.5 (r)-5.9 (at)-6.6 (i)2.6 (on i)2.6 (n)10.6 ( m)-5.9 (o)10.5 (r)-5.9 (e )11.3 (t)-6.6 (ha)10.5 (n 40%)6.6 ( o)10.5 (f)-6.6 ( c)-2 (as)-2 (es)8.9 (.)-6.6 ( )11.2 (I)-6.6 (n a)]TJ -0.013 Tc 0.013 Tw [(n)-11.3 (ot)-17.6 (he)-11.3 (r)]TJ 0 Tc 0 Tw 22.935 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(r)4.9 (epor)4.9 (t)-6.6 (,)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 311.64 73.2 Tm (374)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 323.16 69.24 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(oper)-6 (at)-6.7 (i)2.7 (v)8.8 (e )]TJ 0.007 Tw -27.424 -1.37 Td [(m)-6 (ana)10.6 (g)-11.2 (em)-6 (en)10.5 (t)-6.6 ( w)13.5 (as)-2 ( al)2.6 (t)-6.6 (e)10.5 (r)-5.9 (e)10.5 (d i)2.7 (n 23%)6.6 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.6 ( t)-6.7 (o)10.6 (t)-6.7 (al)2.6 ( )11.3 (gr)-5.9 (ou)10.5 (p due )11.2 (t)-6.6 (o )11.2 (f)-17.4 (i)2.6 (ndi)2.6 (n)10.5 (g)-11.2 (s)8.9 ( on )11.2 (t)-6.6 (he )]TJ 0 -1.38 Td [(pr)-6 (eoper)-5.9 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e ul)2.6 (t)-6.6 (r)-6 (as)-2 (ound.)4.2 ( )11.3 (T)-10.6 (hes)-2 (e)10.6 ( s)-2 (t)-6.6 (udi)2.6 (es)8.9 ( i)2.6 (ndi)2.6 (c)-2 (at)-6.6 (e )11.3 (t)-6.6 (h)10.5 (at)-6.7 ( p)10.6 (r)-6 (eoper)-5.9 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e )]TJ 34.554 43.033 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2 (ound ha)10.6 (s)-2.1 ( a)10.6 ( hi)2.6 (g)-11.2 (h)10.5 ( s)-2 (e)10.6 (ns)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (i)2.6 (t)-17.5 (y)8.9 ( )11.3 (f)]TJ 14.685 0 Td [(or)4.9 ( nodal)2.6 ( di)2.7 (s)-2 (eas)8.9 (e and w)13.5 (i)2.6 (l)2.6 (l)2.6 ( det)-6.6 (ec)-2 (t)-6.6 ( )]TJ -14.685 -1.38 Td [(nonpal)2.6 (pabl)2.7 (e nodal)2.6 ( m)-5.9 (et)-6.6 (a)10.5 (s)-2 (t)-6.6 (as)-2 (es)8.9 ( i)2.6 (n 20%)6.5 ( t)-6.6 (o)10.5 ( 33%)6.5 ( o)10.5 (f)-6.6 ( )11.3 (pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 (,)4.3 ( and)10.5 ( ul)2.6 (t)-6.6 (r)-5.9 (as)-2 (ound)10.5 ( )]TJ 0 -1.37 Td [(s)-2 (houl)2.6 (d al)2.6 (t)-6.6 (er)5 ( t)-6.6 (he)10.5 ( i)2.6 (ndex)8.9 ( oper)-6 (at)-6.6 (i)2.6 (on i)2.6 (n a)10.5 ( s)-2 (i)2.6 (m)-6 (i)2.7 (l)2.6 (ar)4.9 ( per)-5.9 (c)-2 (e)10.5 (nt)-6.6 (a)10.6 (g)-11.3 (e o)10.5 (f)-6.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 (.)-6.7 ( )11.3 (I)-6.6 (n )11.2 (m)-5.9 (os)8.9 (t)-6.6 ( )]TJ 0 -1.38 Td [(c)-2 (as)-2 (es)-2 (,)4.3 ( l)2.6 (es)-2 (i)2.7 (ons)-1.9 ( s)-2 (us)-2 (pi)2.6 (c)-2 (i)2.6 (ou)10.6 (s)-2 ( )11.2 (f)-17.5 (o)10.6 (r)-6 ( l)2.6 (oc)-2 (o)10.5 (r)-6 (e)10.6 (g)-11.3 (i)2.7 (onal)2.6 ( r)-5.9 (ec)-2 (u)10.5 (r)-5.9 (r)-6 (e)10.5 (nc)-2 (e,)-6.6 ( w)13.4 (hi)2.6 (c)-2 (h ar)-6 (e a)10.5 (m)-5.9 (enabl)2.6 (e)10.5 ( )]TJ 0 -1.37 Td [(t)-6.6 (o needl)2.6 (e bi)2.6 (ops)-2 (y)8.9 (,)-6.6 ( )11.2 (s)-2 (houl)2.6 (d )11.3 (be i)2.6 (nt)-6.6 (er)4.9 (r)-5.9 (o)10.5 (g)-11.2 (at)-6.6 (ed)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h FN)2.6 (A)2 ( bi)2.6 (ops)-2 (y)8.8 ( be)10.5 (f)-17.5 (or)-6 (e)10.6 ( s)-2 (ur)4.9 (g)-11.2 (e)10.5 (r)-5.9 (y)8.8 (.)-6.6 ( )]TJ 0.002 Tw 0 -1.38 Td (Tg)Tj 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 1.446 0 Td [(w)13.5 (as)-2 (hout)-6.6 ( as)-2 (s)-2 (ay)8.9 ( m)-6 (ay)8.8 ( b)10.5 (e a us)-2 (e)10.5 (f)-6.6 (ul)2.6 ( ad)10.6 (j)-8.3 (unc)-2 (t)4.3 ( t)-6.7 (o)10.6 ( FN)13.5 (A)1.9 ( bi)2.6 (ops)-2 (y)8.9 ( i)2.7 (n t)-6.6 (hes)-2 (e )11.2 (c)-2 (as)-2 (es)]TJ -0.006 Tc 0.006 Tw 30.576 0 Td (, )Tj -0.005 Tc 0.01 Tw -32.022 -1.37 Td [(p)-3.3 (a)-3.4 (r)-9 (t)-9.6 (ic)-5 (u)-3.3 (la)-3.4 (r)-8.9 (ly)5.8 ( if)-9.6 ( c)-5 (y)5.8 (t)-9.6 (o)-3.3 (lo)7.5 (g)-14.2 (y)5.8 ( is)-5 ( )11.3 (n)-3.4 (e)-3.3 (g)-14.3 (a)7.6 (t)-9.7 (iv)5.9 (e)]TJ 14.554 0 Td [(.)-9.6 ( Cr)-9 (o)-3.3 (s)-5 (s)]TJ 0 Tc 0 Tw 3.163 0 Td (-)Tj -0.005 Tc 0.01 Tw 0.337 0 Td [(s)-5 (e)-3.4 (c)-5 (t)-9.6 (io)-3.3 (n)-3.4 (a)7.5 (l im)-8.9 (a)-3.4 (g)-14.2 (in)7.5 (g)-3.3 ( \()-8.9 (C)10.5 (T)-13.6 ( o)7.5 (r)-9 ( M)12.8 (RI)-9.6 (\))-9 ( )]TJ -0.002 Tc 0.007 Tw -18.054 -1.38 Td [(s)-2 (houl)2.6 (d be per)4.9 (f)-6.6 (or)4.9 (m)-6 (ed)10.5 ( i)13.5 (f)-17.5 ( )11.3 (t)-6.6 (h)10.5 (e t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d l)2.6 (es)]TJ 16.402 0 Td [(i)2.6 (on i)2.6 (s)-2 ( )11.3 (f)-17.5 (i)2.6 (x)8.9 (ed,)4.2 ( )11.3 (bul)2.6 (k)-12.8 (y)8.8 (,)-6.6 ( o)10.6 (r)-6 ( s)-2 (ubs)8.9 (t)-6.6 (er)-5.9 (nal)13.4 (.)-6.6 ( )]TJ -16.402 -1.37 Td [(I)-6.6 (odi)2.6 (nat)-6.6 (ed c)-2 (o)10.5 (nt)4.2 (r)-5.9 (as)-1.9 (t)4.2 ( i)2.6 (s)-2 ( )11.3 (r)-6 (e)10.6 (qui)2.6 (r)-6 (ed )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( op)10.6 (t)-6.7 (i)2.6 (m)-5.9 (al)2.7 ( c)-2.1 (e)10.6 (r)-6 (v)8.9 (i)2.6 (c)-2 (al)2.6 ( i)2.6 (m)-6 (ag)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( w)13.4 (i)2.7 (t)-6.7 (h C)13.5 (T)]TJ -0.006 Tc 0.006 Tw 28.859 0 Td (, )Tj -0.002 Tc 0.007 Tw -28.859 -1.38 Td [(al)2.6 (t)-6.6 (houg)-11.2 (h)10.5 ( i)2.6 (odi)2.7 (nat)-6.6 (ed c)-2 (on)10.5 (t)-6.6 (r)4.9 (as)-2 (t)-6.6 ( w)13.5 (i)2.6 (l)2.6 (l)2.6 ( del)2.6 (a)-11.2 (y)8.9 ( t)-6.6 (r)-5.9 (eat)4.2 (m)-5.9 (en)10.6 (t)-6.6 ( )11.2 (w)2.6 (i)2.6 (t)-6.6 (h R)2.6 (A)2 (I)]TJ 24.772 0 Td [(.)4.3 ( E)1.9 (v)8.9 (al)2.7 (uat)-6.7 (i)2.7 (on o)10.5 (f)-17.5 ( )]TJ -24.772 -1.37 Td [(v)8.9 (oc)-2 (al)2.6 ( c)-2 (or)-5.9 (d m)-5.9 (obi)2.6 (l)2.6 (i)2.6 (t)-6.6 (y)8.9 ( )]TJ 0.002 Tw [(m)-6 (ay)]TJ 0 Tc 0 Tw 10.359 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(be c)-2 (ons)-2 (i)2.6 (der)-5.9 (ed)]TJ 0 Tc 0 Tw 6.261 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(f)-17.5 (o)10.5 (r)-5.9 ( pa)10.6 (t)-6.7 (i)2.7 (ent)4.2 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h abnor)-6 (m)-5.9 (al)13.5 ( v)8.9 (oi)2.6 (c)-2 (e,)-6.6 ( a )]TJ -0.007 Tc -17.163 -1.38 Td [(s)-7 (u)-5.4 (rg)]TJ -0.002 Tc 1.946 0 Td [(i)2.6 (c)-2 (al)2.6 ( hi)2.6 (s)-2 (t)-6.6 (or)-6 (y)8.9 ( i)2.6 (nv)8.9 (ol)2.6 (v)-2 (i)2.6 (ng)-11.2 ( )11.3 (t)-6.6 (he )11.3 (r)-6 (ec)-2 (ur)4.9 (r)-5.9 (ent)4.2 ( l)2.6 (ar)-5.9 (y)8.8 (ng)-11.2 (eal)2.6 ( o)10.5 (r)-6 ( v)8.9 (ag)-11.3 (us)8.9 ( ner)-6 (v)8.9 (es)-2 (,)4.3 ( i)2.6 (nv)8.8 (as)-2 (i)2.6 (v)8.9 (e )]TJ -1.946 -1.37 Td [(di)2.6 (s)-2 (eas)-2 (e,)-6.6 ( o)10.5 (r)-5.9 ( bul)13.5 (k)-12.9 (y)8.9 ( di)2.6 (s)-2 (eas)8.9 (e o)10.6 (f)-6.6 ( t)-6.7 (he)10.5 ( c)-2 (ent)4.3 (r)-6 (al)2.6 ( nec)8.9 (k)]TJ 0 Tc 0 Tw 19.609 0 Td (.)Tj 0.272 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(V)2 (oc)-2 (al)2.6 ( c)-2 (or)-5.9 (d)10.5 ( m)-6 (obi)2.6 (l)2.7 (i)2.6 (t)-6.6 (y)8.8 ( m)-5.9 (ay)8.9 ( be )]TJ -20.163 -1.38 Td [(ev)8.8 (al)2.6 (uat)-6.6 (ed by)8.9 ( ul)2.6 (t)-6.6 (r)-6 (as)-2 (ound,)4.2 ( m)-5.9 (i)2.6 (r)4.9 (r)-6 (or)4.9 ( i)2.6 (ndi)2.6 (r)-5.9 (ec)-2 (t)4.3 ( l)2.6 (ar)-6 (y)8.9 (ng)-11.2 (os)-2 (c)8.8 (opy)8.9 (,)-6.6 ( or)-5.9 ( )11.3 (f)-17.5 (i)2.6 (be)10.5 (r)]TJ 0 Tc 0 Tw 27.043 0 Td (-)Tj -0.013 Tc 0.013 Tw 0.337 0 Td [(o)-11.3 (pt)-17.6 (i)-8.4 (c)-13 ( )]TJ -0.002 Tc 0.002 Tw -27.38 -1.37 Td [(l)2.6 (ar)-6 (y)8.9 (ng)-11.2 (os)-2 (c)-2 (opy)]TJ 0 Tc 0 Tw 5.87 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 472.92 305.4 Tm (375)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 484.56 301.44 Tm ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -7.207 -2.38 Td [(T)-10.6 (he)10.5 ( N)2.6 (C)2.6 (C)2.6 (N)2.7 ( P)1.9 (anel)2.6 ( agr)-6 (eed)10.6 ( on )11.2 (t)-6.6 (he c)-2 (ha)10.5 (r)-6 (ac)8.9 (t)-6.7 (er)-6 (i)2.7 (s)-2 (t)-6.7 (i)2.7 (c)-2 (s)8.8 ( o)10.6 (f)-6.7 ( )11.3 (pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( a)10.5 (t)4.3 ( hi)2.7 (g)-11.3 (he)10.5 (r)-5.9 ( )11.2 (r)-5.9 (i)2.6 (s)8.9 (k)-12.9 ( )]TJ 0 -1.37 Td [(w)13.5 (ho r)-6 (eq)-11.2 (ui)2.6 (r)-5.9 (e)10.5 ( )]TJ [(t)-6.6 (o)10.5 (t)-6.6 (al)2.6 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d)10.5 (ec)-2 (t)-6.7 (om)-5.9 (y)8.8 ( and)10.5 ( nec)8.9 (k)-2 ( di)2.6 (s)-2 (s)-2 (ec)-2 (t)4.3 (i)2.6 (on)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 23.152 0 Td [(as)-2 ( t)-6.7 (he)10.5 ( pr)-6 (i)13.5 (m)-6 (ar)-6 (y)8.9 ( )]TJ -0.004 Tw -23.152 -1.37 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( \()-6 (s)-2 (ee )]TJ /TT2 1 Tf 0.007 Tw 6.717 0 Td [(P)12.8 (r)-5.9 (eoper)-6 (a)10.5 (t)4.3 (i)2.6 (v)-2 (e or)-5.9 ( )11.2 (I)-6.6 (nt)4.2 (r)-5.9 (aoper)-6 (a)10.6 (t)-6.6 (i)2.6 (v)-2 (e D)2.6 (ec)-2 (i)13.5 (s)-2 (i)2.6 (on)]TJ 0 Tc 0 Tw (-)Tj -0.005 Tc 0.01 Tw 17.598 0 Td [(M)1.9 (a)-3.3 (k)-5 (in)-3.4 (g)-3.3 ( Cr)-8.9 (it)-9.6 (e)-3.4 (r)-8.9 (ia)]TJ /TT0 1 Tf 0 Tc 0 Tw 6.707 0 Td ( )Tj -0.013 Tc 0.013 Tw 0.283 0 Td [(i)-8.4 (n )]TJ -0.005 Tc 0.01 Tw -31.304 -1.38 Td [(t)-9.6 (h)-3.4 (e)-3.3 ( NCCN )]TJ -0.002 Tc 0.007 Tw [(G)4.2 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (or)4.9 ( P)1.9 (api)2.6 (l)2.7 (l)2.6 (ar)-5.9 (y)8.8 ( [)-6.6 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d])-6.6 ( C)2.6 (a)10.6 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a)]TJ -0.007 Tc (\).)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 680.28 233.64 Tm [(3,)-1.9 (376)-17 (,)-1.9 (37)-16.9 (7)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 711.24 229.68 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 ( t)-6.6 (ot)-6.6 (al)2.7 ( )]TJ -28.022 -1.37 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( i)2.6 (s)-2 ( )11.3 (r)-6 (ec)-2 (o)10.5 (m)-6 (m)5 (ended )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.7 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h any)8.9 ( one o)10.5 (f)-17.5 ( )11.3 (t)-6.6 (he )11.3 (f)-6.7 (ol)2.6 (l)2.6 (ow)13.4 (i)2.7 (ng)-11.2 ( )]TJ -0.004 Tw 0 -1.38 Td [(f)-6.6 (ac)-2 (t)-6.6 (o)10.6 (r)-6 (s)-2 (,)4.3 ( )-10.6 (i)2.6 (nc)-2 (l)2.6 (udi)2.7 (ng:)-6.6 ( k)-12.9 (now)13.4 (n )-10.6 (di)2.6 (s)-2 (t)-6.6 (ant)4.3 ( m)-6 (et)-6.6 (as)8.9 (t)]TJ 0.007 Tw 17.402 0 Td [(as)-2 (es)8.9 (,)-6.6 ( ex)8.9 (t)-6.6 (r)4.9 (at)-6.6 (hy)8.9 (r)-6 (oi)2.6 (dal)2.6 ( ex)8.9 (t)-6.6 (ens)-2 (i)2.6 (on,)-6.6 ( )]TJ -17.402 -1.37 Td [(t)-6.6 (um)-5.9 (o)10.5 (r)-5.9 ( )11.2 (gr)-6 (eat)-6.6 (e)10.6 (r)-6 ( )11.3 (t)-6.7 (han 4)10.5 ( c)8.9 (m)-6 ( )11.3 (i)2.6 (n di)2.6 (am)-6 (et)-6.6 (e)10.5 (r)-6 (,)4.3 ( c)-2 (er)-5.9 (v)8.9 (i)2.6 (c)-2 (al)2.6 ( l)2.6 (y)8.9 (m)-5.9 (ph node )11.2 (m)-5.9 (et)-6.6 (a)10.5 (s)-1.9 (t)-6.7 (as)-2 (es)8.9 (,)-6.6 ( o)10.5 (r)-5.9 ( )]TJ 0 -1.38 Td [(poor)-6 (l)2.6 (y)8.9 ( di)2.6 (f)-6.6 (f)-6.6 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.7 (ed hi)2.6 (s)8.9 (t)4.2 (ol)2.6 (og)-11.3 (y)8.9 (.)-6.6 ( )11.3 (T)-10.6 (ot)-6.6 (al)13.5 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (o)10.5 (m)-5.9 (y)8.8 ( )0.5 (m)-6 (ay)8.9 ( be c)-2 (on)10.5 (s)-2 (i)2.6 (der)-5.9 (ed )11.2 (f)4.3 (or)-5.9 ( )]TJ 0 -1.37 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h bi)2.6 (l)2.6 (at)-6.7 (er)-6 (al)2.6 ( no)10.5 (dul)2.6 (ar)-5.9 (i)2.6 (t)-6.6 (y)8.9 ( or)-5.9 ( a)10.5 ( pr)-5.9 (i)2.6 (or)5 ( ex)8.9 (pos)-2 (ur)-5.9 (e )11.3 (t)-6.6 (o )11.2 (r)-5.9 (adi)2.6 (at)-6.6 (i)2.6 (on \()4.9 (c)-2 (at)-6.6 (e)10.5 (g)-11.2 (o)10.5 (r)-5.9 (y)]TJ 0 Tc 0 Tw 32.185 0 Td ( )Tj -0.002 Tc 0.007 Tw -32.185 -1.38 Td [(2B)1.9 ( )11.3 (f)-17.5 (or)5 ( r)-6 (adi)2.6 (a)10.5 (t)-6.6 (i)2.7 (on ex)8.9 (pos)-2 (ur)4.9 (e\))-6 (.)4.3 ( )]TJ [(C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 (l)-8.3 (y)8.9 ( pos)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (e and)-11.2 (/)-6.6 (or)5 ( bi)2.6 (ops)-2 (y)]TJ 0 Tc 0 Tw 25.859 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(pr)-6 (ov)8.9 (en nodal)2.7 ( )]TJ -26.196 -1.37 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 ( s)-2 (houl)2.7 (d be)10.5 ( t)4.2 (r)4.9 (eat)-6.7 (ed w)13.5 (i)2.6 (t)-6.6 (h a )11.3 (f)-6.6 (or)5 (m)-6 (al)2.6 ( c)-2 (o)10.5 (m)4.9 (par)-5.9 (t)4.2 (m)-5.9 (ent)-6.6 (al)2.6 ( )11.3 (r)-6 (es)-2 (ec)8.9 (t)-6.6 (i)2.6 (on.)-6.6 ( )11.3 (I)-6.6 (n)10.5 ( )]TJ 0 -1.38 Td [(t)-6.6 (he c)-2 (en)10.6 (t)-6.6 (r)-6 (al)2.6 ( ne)10.5 (c)8.9 (k)-12.8 (,)4.2 ( t)-6.6 (hi)2.6 (s)8.8 ( i)2.6 (s)-2 ( a)10.6 (c)-2 (hi)2.6 (ev)8.8 (ed t)-6.6 (hr)-6 (ou)10.5 (g)-11.2 (h a)10.6 ( uni)2.6 (l)2.6 (at)4.3 (er)-6 (al)2.6 ( or)4.9 ( bi)2.6 (l)2.6 (at)-6.5 (er)-6 (al)2.6 ( l)2.6 (ev)8.8 (el)2.6 ( V)1.9 (I)-6.6 ( )]TJ -0.004 Tw 0 -1.37 Td [(di)2.6 (s)-2 (s)-2 (ec)-2 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For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 799 0 obj 245 endobj %% Contents for page 86 %% Original object ID: 172 0 800 0 obj << /Length 801 0 R >> stream q endstream endobj 801 0 obj 2 endobj %% Contents for page 86 %% Original object ID: 11418 0 802 0 obj << /Length 803 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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0 Tc 0 Tw 3.489 0 Td ( )Tj 0.272 0 Td ( )Tj EMC /P <>BDC -0.005 Tc 0.01 Tw -12.739 -2.37 Td [(T)-13.6 (h)-3.3 (e)7.5 ( NCCN P)]TJ -0.002 Tc 0.007 Tw 5.815 0 Td [(anel)2.6 ( di)2.6 (d )]TJ 0.002 Tw [(not)4.2 ( )]TJ 5.435 0 Td [(uni)13.5 (f)-17.5 (or)4.9 (m)-6 (l)2.6 (y)]TJ 0 Tc 0 Tw 4.033 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(agr)-6 (ee)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 2.837 0 Td [(abou)10.5 (t)-6.6 ( )11.2 (t)-6.6 (h)10.6 (e pr)-6 (e)10.5 (f)-6.6 (er)4.9 (r)-6 (ed p)10.5 (r)-5.9 (i)2.6 (m)-6 (ar)-6 (y)8.9 ( )]TJ -0.004 Tw -18.402 -1.38 Td [(s)-2 (ur)4.9 (g)-11.3 (er)-5.9 (y)8.8 ( f)-17.5 (o)10.5 (r)-5.9 ( )-10.6 (pa)10.6 (t)-6.7 (i)2.7 (ent)-6.6 (s)8.9 ( )]TJ -0.005 Tc 0.01 Tw 8.815 0 Td [(w)10.5 (it)-9.6 (h)-3.4 ( P)-1 (T)-13.6 (C )]TJ -0.002 Tc 0.007 Tw [(w)13.4 (ho ar)-6 (e)10.6 ( as)-2 (s)-2 (u)10.5 (m)-5.9 (ed )11.3 (t)4.2 (o be a)10.5 (t)-6.6 ( l)2.6 (ow)13.5 (er)-6 ( r)-5.9 (i)2.6 (s)8.8 (k)-2 ( o)10.6 (f)-6.6 ( )]TJ 0.002 Tw -8.815 -1.37 Td [(c)-2 (anc)-2 (er)]TJ 0 Tc 0 Tw 3 0 Td (-)Tj -0.005 Tc -0.001 Tw 0.337 0 Td [(s)-5 (p)7.5 (e)-3.3 (c)-5 (i)10.4 (f)-20.4 (ic)-5.1 ( m)-9 (o)-3.3 (r)1.9 (t)-9.6 (a)-3.4 (lit)-9.6 (y)5.9 (.)-9.6 ( )]TJ -0.002 Tc 0.007 Tw 7.913 0 Td [(A)2 (s)-2 ( p)10.5 (r)-6 (ev)8.8 (i)2.7 (ous)-2 (l)-8.3 (y)8.9 ( m)-6 (ent)-6.6 (i)2.6 (one)10.5 (d,)-6.6 ( )11.3 (t)-6.6 (he ex)8.9 (t)-6.6 (ent)4.2 ( o)10.6 (f)-6.7 ( )11.3 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0.002 Tw -11.25 -1.38 Td [(r)-6 (es)-2 (ec)-1.9 (t)-6.7 (i)2.7 (on)]TJ 0 Tc 0 Tw <97>Tj -0.002 Tc 0.007 Tw [(i)2.6 (ps)-2 (i)2.6 (l)2.7 (at)-6.6 (er)-5.9 (al)13.5 ( l)2.6 (obec)-2 (t)-6.6 (om)-5.9 (y)8.8 ( )]TJ [(v)8.9 (er)-6 (s)-2 (us)8.8 ( t)-6.6 (o)10.5 (t)-6.6 (al)2.6 ( t)-6.6 (hy)8.9 (r)-5.9 (o)10.5 (i)2.6 (dec)-2 (t)-6.6 (om)-6 (y)]TJ 0 Tc 0 Tw 25.924 0 Td <97>Tj -0.011 Tc 0.016 Tw [(i)-6.4 (s)-11 ( ve)-9.4 (r)-14.9 (y )]TJ -0.002 Tc -0.004 Tw -25.924 -1.37 Td [(c)-2 (ont)-6.6 (r)-6 (ov)8.9 (er)-5.9 (s)-2 (i)2.6 (al)2.6 ( f)-17.5 (o)10.6 (r)-6 ( )-10.6 (l)2.6 (ow)13.4 (er)]TJ 0 Tc 0 Tw 9.75 0 Td (-)Tj -0.005 Tc 0.01 Tw 0.337 0 Td [(r)-9 (i)10.5 (s)-5 (k)-5 ( P)9.8 (T)-13.6 (C,)1.3 ( w)10.5 (h)-3.4 (ic)-5 (h)-3.4 ( is)-5 ( r)-9 (e)7.6 (f)-20.5 (le)-3.4 (c)-5 (t)-9.6 (e)7.5 (d)-3.3 ( in)-3.4 ( t)-9.6 (h)-3.4 (e)7.5 ( NCCN c)-5 (a)-3.3 (t)-9.7 (e)7.6 (g)-14.3 (o)7.6 (r)-9 (y)5.9 ( )]TJ -0.002 Tc 0.007 Tw -10.087 -1.38 Td [(2B)1.9 ( r)-5.9 (ec)-2 (o)10.5 (m)-5.9 (m)-6 (enda)10.5 (t)-6.6 (i)2.6 (ons)-2 ( )11.3 (f)-6.6 (or)4.9 ( t)-6.6 (hes)-2 (e)10.5 ( pr)-6 (oc)-2 (ed)10.5 (ur)-5.9 (es)8.9 ( \()-6 (s)-2 (ee)10.5 ( )]TJ /TT2 1 Tf [(I)4.3 (ps)-2 (i)2.6 (l)2.7 (at)-6.6 (er)-5.9 (al)2.7 ( Lobec)-2 (t)-6.6 (o)10.5 (m)-6 (y)8.9 ( )]TJ 0 -1.37 Td [(V)2 (er)-5.9 (s)-2.1 (us)-2 ( To)10.5 (t)-6.6 (al)2.6 ( Thy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (o)10.5 (m)-5.9 (y)]TJ /TT0 1 Tf 0 Tc 0 Tw 12.413 0 Td ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(in)7.5 ( t)-9.6 (h)-3.4 (is)-5 ( Dis)-5 (c)-5 (u)-3.3 (s)-5.1 (s)-5 (io)-3.3 (n)7.5 (\))-8.9 (.)1.2 ( L)]TJ -0.002 Tc 0.007 Tw 9.12 0 Td [(obec)-2 (t)-6.6 (om)-5.9 (y)8.8 ( pl)2.6 (us)-2 ( )]TJ 0.002 Tw -21.815 -1.37 Td [(i)2.6 (s)-2 (t)-6.6 (hm)-6 (us)-2 (ec)8.9 (t)-6.6 (o)10.5 (m)-6 (y)]TJ 0 Tc 0 Tw 6.641 0 Td ( )Tj -0.005 Tc 0.005 Tw 0.283 0 Td [(is)-5 ( )]TJ -0.002 Tc 0.007 Tw 1 0 Td [(r)-6 (ec)-2 (o)10.5 (m)5 (m)-6 (ended )11.3 (f)-6.6 (or)4.9 ( pat)-6.6 (i)2.6 (en)10.6 (t)-6.6 (s)-2 ( w)13.4 (ho c)-2 (annot)4.3 ( \()-6 (o)10.6 (r)-6 ( )11.3 (r)-6 (e)10.6 (f)-17.5 (us)8.9 (e )11.3 (t)-6.6 (o\))4.9 ( )]TJ -7.924 -1.38 Td [(t)-6.6 (a)10.5 (k)-12.9 (e )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d hor)5 (m)-6 (one )11.2 (r)-5.9 (ep)10.5 (l)2.7 (ac)-2 (em)-6 (ent)4.3 ( t)-6.6 (he)10.5 (r)-5.9 (apy)8.9 ( )11.2 (f)-17.4 (or)4.9 ( t)-6.6 (he)10.5 ( )11.3 (r)-6 (em)-5.9 (ai)2.7 (nder)4.9 ( o)10.6 (f)-6.7 ( t)-6.6 (hei)13.5 (r)-5.9 ( )]TJ -0.011 Tc 0.011 Tw 0 -1.37 Td [(l)-6.4 (i)-17.2 (ve)-9.3 (s)-11 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 48.6 218.52 Tm (213)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 60.12 214.56 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(N)2.6 (ot)-6.6 (e t)-6.6 (hat)4.3 ( s)-2 (o)10.5 (m)-6 (e )11.3 (pat)-6.7 (i)2.7 (ent)-6.6 (s)-2 ( p)10.6 (r)-6 (e)10.5 (f)-17.4 (e)10.5 (r)-6 ( )11.3 (t)-6.6 (o)10.5 ( hav)8.9 (e t)-6.6 (o)10.5 (t)-6.5 (al)2.6 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (o)10.5 (m)-5.9 (y)8.9 ( t)-6.6 (o)10.5 ( )]TJ -3.598 -1.38 Td [(av)8.8 (oi)2.6 (d hav)-2 (i)2.7 (ng)-11.2 ( a s)-2 (e)10.6 (c)-2 (ond s)8.9 (ur)4.9 (g)-11.2 (er)-6 (y)8.9 ( \()-6 (i)2.6 (e,)4.3 ( c)-2 (o)10.5 (m)-6 (pl)2.6 (et)-6.7 (i)2.7 (on )11.2 (t)-6.6 (h)10.5 (y)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 (\))-6 (.)-6.6 ( )11.3 (O)4.3 (t)-6.7 (her)5 ( )]TJ 0 -1.37 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( p)10.5 (r)-5.9 (e)10.5 (f)-17.5 (e)10.5 (r)-5.9 ( )11.2 (t)-6.6 (o)10.6 ( hav)8.8 (e a )11.3 (l)2.6 (obec)-2 (t)-6.6 (om)-5.9 (y)8.8 ( i)2.6 (n an a)10.5 (t)4.3 (t)-6.6 (em)-5.9 (p)10.5 (t)-6.6 ( )]TJ 21.88 0 Td [(t)-6.6 (o av)8.9 (oi)2.6 (d t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d hor)4.9 (m)-6 (one)10.6 ( )]TJ -0.004 Tw -21.88 -1.38 Td [(r)-6 (epl)2.7 (ac)-2 (em)-6 (en)10.5 (t)-6.6 ( t)-6.7 (her)-5.9 (apy)8.9 (.)-6.6 ( )]TJ 0 Tc 0 Tw ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw 0 -2.37 Td [(A)2 ( s)-2 (t)-6.6 (udy)8.9 ( )]TJ -0.013 Tc 0.013 Tw (of)Tj 0 Tc 0 Tw 4.435 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(m)-6 (or)-6 (e)10.6 ( t)-6.6 (han)10.5 ( 50)10.6 (00 pat)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( )11.3 (f)-6.6 (ound )11.3 (t)-6.6 (hat)4.2 ( s)-2 (u)10.6 (r)-6 (v)8.9 (i)-8.3 (v)8.9 (al)2.7 ( of)-6.6 ( pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( a)10.5 (f)-6.6 (t)-6.6 (e)10.5 (r)-6 ( )]TJ -4.707 -1.38 Td [(par)-6 (t)-6.6 (i)2.7 (al)2.6 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (o)10.5 (m)-5.9 (y)8.9 ( w)13.4 (as)-2 ( s)-2 (i)2.6 (m)-6 (i)2.7 (l)2.6 (ar)-5.9 ( )11.2 (t)-6.6 (o )11.3 (t)-6.7 (he)10.5 ( s)-2 (ur)-6 (v)8.9 (i)2.6 (v)8.9 (al)2.6 ( a)-11.2 (f)-6.6 (t)-6.6 (e)10.5 (r)-5.9 ( )11.2 (t)-6.6 (ot)-6.6 (al)2.6 ( )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (o)10.5 (m)-5.9 (y)8.9 ( )]TJ 0 -1.37 Td [(f)-6.6 (or)5 ( pat)-6.7 (i)2.7 (ent)-6.6 (s)]TJ 0 Tc 0 Tw 4.935 0 Td ( )Tj -0.013 Tc 0.013 Tw 0.283 0 Td (at)Tj 0 Tc 0 Tw 0.826 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(l)2.6 (ow)13.4 ( and hi)2.7 (g)-11.3 (h)]TJ 0 Tc 0 Tw 5.587 0 Td ( )Tj -0.011 Tc 0.011 Tw 0.283 0 Td [(r)-15 (i)-6.3 (sk)]TJ 0 Tc 0 Tw 1.543 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 178.32 116.4 Tm (380)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 189.84 112.44 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 (n obs)-2 (er)-6 (v)8.9 (at)-6.6 (i)2.6 (onal)2.6 ( s)-2 (t)-6.6 (udy)8.9 ( \()-6 (S)2 (E)1.9 (E)2 (R)2.6 ( )]TJ -15.348 -1.38 Td [(dat)-6.6 (abas)-2 (e\))4.9 ( i)2.6 (n )11.3 (m)-6 (or)-5.9 (e)10.5 ( t)-6.6 (han)10.5 ( 3)10.5 (5,)-6.6 (000 pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h P)2 (T)-10.6 (C)2.6 ( l)13.5 (i)2.6 (m)-5.9 (i)2.6 (t)-6.6 (ed )11.2 (t)-6.6 (o )11.2 (t)-6.6 (he )11.3 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.37 Td [(g)-11.2 (l)2.6 (and s)-2 (u)10.6 (gg)-11.2 (e)10.5 (s)-2 (t)-6.6 (s)8.9 ( t)-6.6 (ha)10.6 (t)-6.6 ( )11.2 (s)-2 (ur)-6 (v)8.9 (i)2.6 (v)8.9 (al)2.6 ( i)2.6 (s)-2 ( s)-2 (i)2.6 (m)-5.9 (i)2.6 (l)2.6 (ar)-6 ( w)13.5 (het)-6.6 (her)-6 ( \()-5.9 (o)10.5 (r)-6 ( )11.3 (not)-6.6 (\))4.9 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( ar)5 (e )11.3 (t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (ed )]TJ 0 -1.38 Td [(i)2.6 (n t)-6.6 (he )]TJ 2.717 0 Td [(f)-17.5 (i)13.5 (r)-6 (s)8.9 (t)-6.6 ( y)8.9 (ear)-6 ( a)10.5 (f)-6.6 (t)-6.6 (e)10.6 (r)-6 ( di)2.6 (a)10.6 (gnos)-2 (i)2.6 (s)-2 ( and w)13.5 (het)-6.6 (her)-6 ( )11.3 (t)-6.6 (hey)8.9 ( u)10.5 (nder)5 (g)-11.3 (o l)2.6 (obec)-2 (t)-6.7 (o)10.6 (m)-6 (y)8.9 ( or)5 ( )]TJ -0.004 Tw -2.717 -1.37 Td [(t)-6.6 (ot)-6.6 (al)2.6 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (dec)-2 (t)-6.6 (om)-5.9 (y)]TJ 0 Tc 0 Tw 8.37 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 119.04 55.68 Tm (381)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 130.56 51.72 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(H)2.6 (ow)13.4 (e)-11.2 (v)8.9 (er)-5.9 (,)-6.6 ( m)-6 (os)8.9 (t)-6.6 ( )11.2 (g)-11.2 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (\()-6 (e)10.5 (g)-11.2 (,)4.3 ( N)2.6 (C)2.6 (C)2.6 (N)2.6 (,)-6.6 ( A)12.8 (T)-10.5 (A)1.9 (\))4.9 ( do no)10.5 (t)-6.6 ( )]TJ 24.576 41.87 Td [(r)-6 (ec)-2 (om)5 (m)-6 (end)10.5 ( ac)-2 (t)-6.6 (i)2.6 (v)8.9 (e s)-2 (ur)-6 (v)8.9 (ei)2.7 (l)2.5 (l)2.7 (anc)-2 (e )11.3 (f)-17.5 (or)4.9 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (i)2.6 (t)-6.6 (h P)2 (T)-10.6 (C)2.6 (.)]TJ 0 Tc 0 Tw 6.96 -0 0 6.96 664.44 517.92 Tm (3)Tj 11.04 -0 0 11.04 668.28 513.96 Tm ( )Tj 0.283 0 Td (A)Tj -0.002 Tc 0.007 Tw 0.663 0 Td [(no)10.5 (t)-6.6 (her)4.9 ( s)8.9 (t)-6.7 (udy)8.9 ( )]TJ -0.013 Tc 0.013 Tw (of)Tj 0 Tc 0 Tw 6.587 0 Td ( )Tj -0.002 Tc 0.007 Tw -31.38 -1.38 Td [(2784 pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-6 (e)10.6 (nt)-6.6 (i)2.6 (at)-6.6 (ed )]TJ 14.348 0 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (no)10.6 (m)4.9 (a )]TJ [(\()-5.9 (86)10.5 (%)-4.3 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ -0.004 Tc 0.004 Tw [(PT)-12.5 (C)]TJ -0.002 Tc -0.004 Tw 14.783 0 Td [(\))-6 ( f)-6.6 (ound )]TJ 0.007 Tw -29.13 -1.37 Td [(t)-6.6 (hat)4.3 ( t)-6.7 (o)10.6 (t)-6.6 (al)2.6 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (dec)-2 (t)]TJ 8.435 0 Td [(o)10.5 (m)-5.9 (y)8.8 ( )11.3 (w)13.5 (as)-2 ( as)-2 (s)-2 (oc)-2 (i)2.7 (at)-6.6 (ed w)13.5 (i)2.6 (t)-6.6 (h i)2.6 (nc)-2 (r)4.9 (eas)-2 (ed s)-2 (ur)-6 (v)8.9 (i)2.6 (v)8.9 (al)2.6 ( i)2.6 (n pat)-6.6 (i)2.6 (ent)-6.6 (s)]TJ 0 Tc 0 Tw 24.076 0 Td ( )Tj -0.002 Tc 0.002 Tw -32.511 -1.38 Td [(at)-6.6 ( )]TJ -0.016 Tc 0.016 Tw 1.12 0 Td [(h)-14.4 (ig)-25.2 (h)]TJ 0 Tc 0 Tw 1.88 0 Td ( )Tj -0.011 Tc 0.011 Tw 0.272 0 Td [(r)-15 (i)-6.3 (sk)]TJ 0 Tc 0 Tw 1.554 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 461.4 472.32 Tm (255)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 472.92 468.36 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 ( s)8.8 (t)-6.6 (udy)8.9 ( i)2.6 (n 52,)-6.6 (173 pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( )11.2 (f)-17.5 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[(w)13.5 (ho under)-6 (g)-11.2 (o l)2.6 (obec)8.9 (t)-6.6 (om)-6 (y)8.9 ( )11.3 (pl)2.6 (us)-2 ( i)2.7 (s)-2 (t)-6.6 (hm)-5.9 (u)10.5 (s)-2 (ec)-2 (t)-6.6 (o)10.6 (m)-6 (y)8.9 (,)]TJ 0 Tc 0 Tw 19.891 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(c)-2 (o)10.5 (m)-5.9 (pl)2.6 (et)-6.6 (i)2.6 (on )-10.6 (o)10.5 (f)-6.6 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (dec)-2 (t)-6.6 (om)4.9 (y)8.8 ( )]TJ -20.174 -1.38 Td [(i)2.6 (s)-2 ( )-10.6 (r)-5.9 (ec)-2 (o)10.5 (m)-5.9 (m)-6 (ended)10.6 ( f)-17.5 (o)10.6 (r)-6 ( )-10.6 (any)8.9 ( one )-10.6 (o)10.5 (f)-6.6 ( )-10.6 (t)-6.6 (he)10.5 ( f)-17.4 (ol)2.6 (l)2.6 (ow)13.5 (i)2.6 (ng)-11.2 ( )-10.6 (r)-5.9 (i)2.6 (s)8.8 (k)-2 ( f)-6.6 (ac)-2 (t)-6.6 (or)-6 (s)8.9 (:)-6.6 ( )-10.6 (l)2.6 (a)10.5 (r)5 (g)-11.3 (e t)-6.6 (um)-6 (o)10.6 (r)-6 ( \()-6 (>)-4.9 (4)10.5 ( )]TJ -0.007 Tc 0.012 Tw 0 -1.37 Td [(c)-7 (m)-11 (\),)-11.6 ( p)-5.3 (o)]TJ -0.002 Tc 0.007 Tw 3.326 0 Td [(s)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (e r)-5.9 (es)-2 (ec)-2 (t)-6.6 (i)2.6 (on)10.6 ( m)4.9 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( f)-17.5 (or)5 ( T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (C)13.5 (ar)-5.9 (c)-2 (i)2.6 (nom)-5.9 (a\))4.9 (.)-6.6 ( )]TJ 0 Tc 0 Tw ( )Tj EMC ET endstream endobj 803 0 obj 27277 endobj %% Contents for page 86 %% Original object ID: 173 0 804 0 obj << /Length 805 0 R >> stream Q q BT /Xi84 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 805 0 obj 245 endobj %% Contents for page 87 %% Original object ID: 174 0 806 0 obj << /Length 807 0 R >> stream q endstream endobj 807 0 obj 2 endobj %% Contents for page 87 %% Original object ID: 11419 0 808 0 obj << /Length 809 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (24)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /H2 <>BDC /TT1 1 Tf 0.009 Tc -0.004 Tw 11.04 -0 0 11.04 23.52 513.72 Tm [(R)2.7 (ad)0.5 (i)-6.5 (oa)10.7 (ct)5 (i)-6.5 (v)10.7 (e I)-6.5 (od)11.3 (i)-6.4 (ne)10.7 ( )]TJ -0.009 Tw 9.261 0 Td [(T)11.3 (h)0.5 (er)-4.1 (ap)0.5 (y)]TJ 0 Tc 0 Tw 3.935 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw -13.196 -1.707 Td [(P)2 (os)-2 (t)-6.6 (oper)-6 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e R)2.7 (A)1.9 (I)-6.6 ( adm)-5.9 (i)2.6 (n)10.5 (i)2.6 (s)-2 (t)-6.6 (r)-6 (at)-6.6 (i)2.6 (on)10.5 ( i)2.6 (s)-2 ( r)-6 (e)10.6 (c)-2.1 (om)4.9 (m)-5.9 (ende)10.5 (d w)13.5 (hen a num)-6 (be)10.5 (r)-6 ( o)10.6 (f)-6.6 ( )]TJ 0 -1.37 Td [(c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.7 ( f)-17.4 (ac)8.9 (t)-6.6 (or)-5.9 (s)8.9 ( pr)-6 (edi)2.7 (c)8.8 (t)-6.6 ( a)10.5 ( )11.3 (s)-2 (i)2.6 (g)-11.2 (ni)13.4 (f)-17.4 (i)2.6 (c)-2 (a)]TJ [(nt)4.2 ( r)-5.9 (i)2.6 (s)8.9 (k)-2 ( o)10.5 (f)-6.6 ( r)-6 (e)10.5 (c)-2 (ur)4.9 (r)-6 (e)10.6 (nc)-2 (e,)-6.6 ( di)2.6 (s)8.9 (t)-6.6 (ant)4.3 ( m)-6 (e)10.5 (t)-6.6 (as)8.8 (t)-6.6 (as)-2 (es)-2 (,)4.3 ( )]TJ 0 -1.38 Td [(or)-6 ( di)2.6 (s)-2 (eas)-2 (e)]TJ 0 Tc 0 Tw 4.598 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(s)-2 (pec)-2 (i)13.5 (f)-17.5 (i)2.6 (c)-2 ( )11.3 (m)-6 (or)4.9 (t)-6.6 (a)10.5 (l)2.6 (i)2.6 (t)-6.6 (y)8.9 (.)-6.6 ( C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (opat)-6.6 (hol)2.6 (og)-11.2 (i)2.6 (c)-2 ( )11.3 (f)-17.5 (ac)8.9 (t)-6.6 (or)-5.9 (s)8.9 ( c)-2 (an be)10.5 ( us)-2 (ed)10.6 ( t)-6.7 (o)10.6 ( )]TJ -4.935 -1.37 Td [(g)-11.2 (ui)2.6 (de dec)-2 (i)2.7 (s)-2 (i)2.6 (ons)8.8 ( 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(e)10.5 (c)-2 (ur)4.9 (r)-6 (enc)-2 (e/)-6.6 (di)2.6 (s)-2 (eas)-2 (e)]TJ 0 Tc 0 Tw 17.228 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(s)-2 (pec)-2 (i)13.5 (f)-17.5 (i)2.6 (c)8.9 ( m)4.9 (or)-6 (t)-6.6 (al)2.7 (i)2.6 (t)-6.7 (y)8.9 (;)]TJ 0 Tc 0 Tw 7.641 0 Td ( )Tj -0.013 Tc 0.018 Tw 0.283 0 Td [(2\))-16.9 ( R)-8.4 (A)-9.1 (I)-6.7 ( i)-8.4 (s)-13 ( n)-11.4 (ot)-17.6 ( )]TJ -0.002 Tc 0.007 Tw -25.489 -1.38 Td [(r)-6 (ec)-2 (om)5 (m)-6 (ended)10.5 ( a)10.6 (f)-6.6 (t)-6.6 (er)4.9 ( l)2.6 (obec)-2 (t)-6.6 (om)-5.9 (y)8.9 (;)]TJ 0 Tc 0 Tw 13.739 0 Td ( )Tj 0.283 0 Td (3)Tj -0.002 Tc 0.007 Tw 0.554 0 Td [(\))4.9 ( R)2.6 (A)2 (I)-6.6 ( )11.2 (m)-5.9 (ay)8.9 ( be c)-2 (o)10.5 (ns)-2 (i)2.6 (der)-6 (ed )11.2 (f)-17.5 (o)10.6 (r)-6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( )]TJ -14.576 -1.37 Td [(w)2.6 (i)2.6 (t)-6.6 (hout)-6.6 ( )11.2 (gr)-6 (os)-2 (s)-2 ( )11.2 (r)-5.9 (es)-1.9 (i)2.6 (dual)2.6 ( di)13.5 (s)-2 (eas)-2 (e,)-6.6 ( bu)10.5 (t)4.2 ( dat)-6.6 (a)10.6 ( ar)-5.9 (e)10.5 ( c)-2 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(,)]TJ 0 Tc 0 Tw 4.196 0 Td ( )Tj -0.002 Tc 0.007 Tw -32.228 -1.38 Td [(s)-2 (om)-6 (e pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( m)-6 (ay)8.9 ( hav)8.8 (e )11.2 (m)-5.9 (et)-6.7 (as)8.9 (t)-6.6 (at)-6.6 (i)2.6 (c)8.9 ( di)2.6 (s)-2 (eas)-2 (e )11.3 (t)-6.6 (hat)4.2 ( )11.3 (m)-6 (ay)8.9 ( not)-6.6 ( be)10.5 ( a)10.6 (m)-6 (enabl)2.6 (e t)-6.6 (o)10.5 ( )]TJ 0 -1.37 Td [(R)2.6 (A)2 (I)-6.6 ( t)-6.7 (he)10.5 (r)-5.9 (apy)8.9 (,)-6.7 ( w)13.5 (hi)2.6 (c)-2 (h i)2.6 (s)-2 ( al)2.6 (s)-2 (o )11.2 (k)-12.9 (now)13.5 (n as)-2 ( i)2.6 (odi)2.7 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 19.228 0 Td [(r)-6 (e)10.6 (f)-6.6 (r)-6 (ac)8.8 (t)-6.6 (or)-6 (y)8.9 ( )-10.6 (di)2.7 (s)-2 (eas)-2 (e \()-6 (s)-2 (ee )]TJ /TT2 1 Tf 0.007 Tw -19.228 -1.38 Td [(Tr)-6 (eat)4.3 (m)-5.9 (ent)4.2 ( of)4.2 ( M)5 (et)-6.6 (as)8.8 (t)-6.6 (at)-6.6 (i)2.6 (c)8.8 ( )11.3 (D)2.6 (i)2.6 (s)-2 (eas)-2 (e N)2.6 (ot)-6.6 ( A)12.9 (m)-6 (enabl)2.6 (e t)4.2 (o R)2.6 (A)2 (I)-6.7 ( The)10.5 (r)-5.9 (apy)]TJ /TT0 1 Tf 0 Tc 0 Tw 27.924 0 Td ( )Tj -0.013 Tc 0.018 Tw 0.283 0 Td [(i)-8.4 (n t)-17.6 (h)-11.3 (e )]TJ -0.002 Tc 0.007 Tw -28.207 -1.37 Td [(N)2.6 (C)2.6 (C)2.6 (N)2.6 ( G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (or)4.9 ( P)1.9 (api)2.6 (l)2.7 (l)2.6 (ar)-5.9 (y)8.8 ( [)-6.6 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d])-6.7 ( C)2.6 (ar)-6 (c)-2 (i)2.7 (no)10.5 (m)-5.9 (a\))4.9 (.)]TJ 0 Tc 0 Tw 23.272 0 Td ( )Tj 0.272 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -23.543 -2.37 Td [(A)2 (l)2.6 (l)2.6 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( s)-2 (houl)2.7 (d )11.3 (be ex)8.9 (am)-5.9 (i)2.6 (ned,)-6.7 ( and)10.5 ( pal)2.6 (pabl)2.7 (e ne)10.5 (c)-2 (k)-2 ( di)2.6 (s)-2 (eas)-2 (e )11.3 (s)-2 (houl)2.6 (d be )]TJ 0 -1.38 Td [(s)-2 (ur)4.9 (g)-11.3 (i)2.7 (c)-2 (al)2.6 (l)2.6 (y)8.9 ( r)-5.9 (es)-2 (ec)-2 (t)-6.6 (ed be)10.5 (f)-6.6 (or)4.9 (e any)8.9 ( R)2.6 (A)2 (I)-6.6 ( )11.2 (t)-6.6 (r)-5.9 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.6 (t)-6.7 (.)4.3 ( A)2 ( n)10.5 (eg)-11.2 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e pr)-5.9 (eg)-11.2 (nan)10.5 (c)-2 (y)8.9 ( t)-6.6 (es)8.9 (t)-6.6 ( i)2.6 (s)8.9 ( )]TJ 0 -1.37 Td [(r)-6 (e)10.6 (q)-11.3 (ui)2.6 (r)-5.9 (ed be)10.5 (f)-6.6 (or)-6 (e)10.6 ( t)-6.7 (he)10.5 ( ad)10.5 (m)-6 (i)2.6 (ni)2.6 (s)-2 (t)-6.6 (r)-6 (at)-6.6 (i)2.6 (on)10.6 ( o)10.5 (f)-6.6 ( R)2.6 (A)1.9 (I)-6.6 ( i)2.6 (n)10.6 ( w)13.4 (om)-6 (en o)10.6 (f)-6.6 ( c)-2.1 (hi)2.6 (l)2.6 (d)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 26.261 0 Td [(bear)-6 (i)2.6 (n)10.5 (g)-11.2 ( )]TJ -0.004 Tw -26.261 -1.38 Td [(pot)-6.6 (ent)-6.6 (i)2.6 (al)2.6 (.)-6.6 ( T)]TJ 0.007 Tw 4.946 0 Td [(he)10.5 ( ad)10.5 (m)-5.9 (i)2.6 (ni)2.6 (s)-2 (t)-6.6 (er)4.9 (ed ac)-2 (t)-6.6 (i)2.6 (v)8.9 (i)2.6 (t)-6.6 (y)8.8 ( of)-6.6 ( R)2.6 (A)]TJ 13.174 0 Td [(I)4.3 ( t)-6.7 (he)10.5 (r)-5.9 (apy)8.8 ( s)-1.9 (houl)2.6 (d be a)10.5 (dj)-8.2 (us)8.9 (t)-6.6 (ed )11.3 (f)-6.6 (or)4.9 ( )]TJ -18.12 -1.37 Td [(pedi)2.6 (at)-6.6 (r)-5.9 (i)2.6 (c)-2 ( pa)10.6 (t)-6.7 (i)2.7 (ent)-6.7 (s)-1.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 109.92 184.32 Tm (270)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 121.44 180.36 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(For)4.9 ( )11.2 (pat)-6.6 (i)2.7 (ent)-6.5 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h unr)-6 (e)10.5 (s)-2 (ec)-2 (t)-6.6 (abl)13.5 (e )11.3 (g)-11.2 (r)-6 (os)-2 (s)8.8 ( )0.5 (r)-6 (e)10.5 (s)-2 (i)2.6 (dual)2.6 ( di)2.6 (s)-2 (eas)-2 (e )]TJ -9.152 -1.38 Td [(i)2.6 (n t)-6.6 (he nec)8.8 (k)-2 ( )11.3 (\()-6 (s)-1.9 (us)-2 (pec)8.9 (t)-6.6 (ed o)10.5 (r)-6 ( pr)4.9 (ov)8.8 (en\))-5.9 ( t)-6.6 (ha)10.5 (t)-6.6 ( i)2.6 (s)8.9 ( r)-5.9 (e)10.5 (f)-6.6 (r)-6 (ac)8.8 (t)-6.6 (or)4.9 (y)8.9 ( t)-6.6 (o R)2.6 (A)2 (I)-6.6 (,)4.2 ( E)2 (B)1.9 (R)13.5 (T)-10.5 ( o)10.5 (r)-6 ( )11.3 (I)-6.6 (M)15.8 (R)2.6 (T)-10.6 ( )]TJ 0 -1.37 Td [(c)-2 (an be c)-2 (on)10.5 (s)-2 (i)2.6 (der)-6 (ed i)13.5 (f)-6.6 ( di)2.6 (s)-2 (e)10.5 (as)-2 (e i)2.6 (s)-2 ( )11.3 (t)-6.6 (hr)-5.9 (ea)10.6 (t)-6.7 (eni)2.6 (ng v)8.8 (i)2.6 (t)-6.6 (al)2.6 ( s)-2 (t)4.3 (r)-6 (uc)-2 (t)-6.7 (u)10.6 (r)-6 (es)-2 ( )11.2 (\()-5.9 (s)-2 (ee)10.6 ( )]TJ /TT2 1 Tf 0 -1.38 Td [(P)2 (os)-2 (t)-6.6 (s)-2 (ur)-6 (gi)2.6 (c)-2 (al)2.6 ( E)2 (v)-2 (al)2.7 (uat)-6.5 (i)2.6 (on)]TJ /TT0 1 Tf 0 Tc 0 Tw 10.359 0 Td ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(in)-3.3 ( t)-9.6 (h)-3.3 (e)7.5 ( NCCN G)-9.5 (u)-3.4 (id)-3.3 (e)-3.4 (lin)-3.3 (e)-3.4 (s)-5 ( )11.2 (f)-9.6 (o)-3.3 (r)-9 ( P)]TJ -0.002 Tc 0.007 Tw 12.967 0 Td [(api)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( [)4.3 (T)-10.6 (hy)8.9 (r)-5.9 (oi)2.6 (d])-6.6 ( )]TJ 0.002 Tw -23.609 -1.37 Td [(C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a\))4.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 83.52 123.6 Tm [(3,)-1.9 (305,)-19.2 (30)-16.9 (6,)-1.8 (3)-17 (84)]TJ 0 Tc 0 Tw 6.414 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.328 0 Td [(3)-17 (86)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 142.08 119.64 Tm ( )Tj 0.293 0 Td ( )Tj EMC /H2 <>BDC /TT1 1 Tf 0.009 Tc -0.004 Tw -11.033 -2.391 Td [(S)2.1 (ur)-4.1 (v)10.6 (ei)-6.5 (l)4.4 (l)-6.5 (an)11.3 (ce)10.7 ( )-10.5 (and)11.3 ( M)-5.8 (ai)4.4 (nt)5.1 (enance)]TJ 0 Tc 0 Tw 14.489 0 Td ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw -14.772 -1.707 Td [(T)-10.6 (he)10.5 ( r)-5.9 (ec)-2 (o)10.5 (m)-5.9 (m)4.9 (endat)-6.6 (i)2.6 (ons)-2 ( )11.3 (f)-6.6 (o)10.5 (r)-6 ( s)-2 (u)10.6 (r)-6 (v)8.9 (ei)2.6 (l)2.6 (l)2.7 (anc)-2 (e and m)-6 (ai)2.6 (nt)-6.6 (e)10.6 (nanc)-2 (e)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 25.098 0 Td [(ar)-6 (e)10.5 ( des)-2 (c)8.9 (r)-6 (i)2.7 (bed i)2.6 (n )]TJ -25.098 -1.37 Td [(t)-6.6 (he al)13.5 (g)-11.2 (or)-6 (i)2.6 (t)-6.6 (h)10.5 (m)5 ( \()-5.9 (s)-2 (ee)10.6 ( )]TJ /TT2 1 Tf [(S)1.9 (ur)-6 (v)-2 (ei)13.4 (l)2.7 (l)2.6 (anc)-2 (e and M)4.9 (ai)2.6 (nt)-6.6 (enanc)-2 (e)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.005 Tc 0.01 Tw 21.891 0 Td [(i)10.5 (n)-3.4 ( t)-9.6 (h)-3.4 (e)7.6 ( NCCN G)-9.6 (u)-3.3 (id)-3.4 (e)-3.3 (lin)-3.4 (e)-3.3 (s)-5 ( )]TJ -0.002 Tc 0.007 Tw -21.891 -1.38 Td [(f)-6.6 (or)5 ( P)1.9 (api)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( [)-6.6 (T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d])-6.6 ( C)2.6 (a)10.6 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a\))4.9 (.)]TJ 0 Tc 0 Tw 6.96 -0 0 6.96 190.56 48 Tm (3)Tj 11.04 -0 0 11.04 194.4 44.04 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 (bout)4.3 ( 85)10.5 (%)-4.2 ( o)10.5 (f)-6.6 ( )11.2 (pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( a)10.5 (r)-5.9 (e )11.2 (c)-2 (ons)-2 (i)2.6 (der)-6 (ed)10.6 ( )]TJ 18.793 42.565 Td [(t)-6.6 (o be)10.5 ( l)2.6 (ow)13.5 ( r)-6 (i)2.6 (s)-2 (k)-2 ( a)10.5 (f)-6.6 (t)-6.6 (er)4.9 ( s)-2 (ur)4.9 (g)-11.2 (e)10.5 (r)-5.9 (y)8.9 ( )11.2 (f)-17.4 (or)4.9 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )0.5 (c)-2.1 (anc)-2 (er)-5.9 (.)]TJ 0 Tc 0 Tw 6.96 -0 0 6.96 669.36 517.92 Tm (3)Tj 11.04 -0 0 11.04 673.2 513.96 Tm ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(I)-6.6 (n pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (ho )]TJ -24.565 -1.38 Td [(hav)8.9 (e had t)-6.6 (ot)-6.6 (al)13.5 ( \()-6 (o)10.5 (r)-5.9 ( nea)10.5 (r)-6 ( )11.3 (t)4.3 (ot)-6.6 (al)2.6 (\))-6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( and)10.5 ( t)4.3 (hy)8.9 (r)-6 (oi)2.6 (d r)-5.9 (em)-5.9 (nan)10.5 (t)-6.6 ( abl)2.6 (at)-6.7 (i)2.7 (on,)4.2 ( )]TJ 0 -1.37 Td [(t)-6.6 (he A)12.8 (T)-10.5 (A)1.9 ( )11.3 (G)-6.6 (ui)2.6 (del)2.7 (i)2.6 (nes)-2 ( de)10.5 (f)-17.4 (i)2.6 (n)10.5 (e )0.5 (t)-6.7 (he)10.5 ( abs)-2 (enc)-2 (e)10.6 ( o)10.6 (f)-6.6 ( per)-6 (s)-2 (i)2.6 (s)8.9 (t)4.3 (ent)-6.7 ( )11.3 (t)-6.6 (um)-6 (o)10.5 (r)-5.9 ( )11.2 (\()-5.9 (al)2.6 (s)-2 (o )11.3 (k)-12.9 (now)13.5 (n a)10.6 (s)-2 ( )]TJ 0 -1.38 Td [(no ev)8.8 (i)2.6 (denc)-2 (e o)10.6 (f)-17.5 ( di)2.7 (s)-2.1 (eas)-2 (e)10.5 ( [)4.2 (N)2.6 (E)2 (D)2.6 (])-6.6 (\))-5.9 ( as)8.9 (:)-6.6 ( 1)10.5 (\))-6 ( abs)-2 (en)10.5 (c)-2 (e o)10.5 (f)-6.6 ( )11.3 (c)-2 (l)2.5 (i)2.7 (ni)2.6 (c)-2 (al)2.6 ( ev)-2 (i)2.6 (denc)-2 (e o)10.5 (f)-17.5 ( )]TJ 0 -1.37 Td [(t)-6.6 (um)-5.9 (o)10.5 (r)-5.9 (;)4.2 ( 2\))4.9 ( abs)-2 (enc)-2 (e)10.5 ( o)10.5 (f)-6.6 ( i)]TJ 9.641 0 Td [(m)-6 (a)10.6 (g)-11.3 (i)2.7 (n)10.5 (g)-11.2 ( ev)8.9 (i)2.6 (denc)-2 (e o)10.5 (f)-6.6 ( t)-6.6 (u)10.5 (m)-5.9 (o)10.5 (r)-6 (;)4.3 ( )11.3 (and 3\))4.9 ( undet)-6.6 (ec)8.8 (t)-6.6 (abl)2.6 (e )11.3 (Tg )]TJ -9.641 -1.38 Td [(l)2.6 (ev)8.8 (e)-11.2 (l)2.6 (s)-2 ( \()-5.9 (dur)-6 (i)2.6 (n)10.5 (g)-11.2 ( ei)2.6 (t)4.3 (her)4.9 ( )11.3 (T)-10.6 (S)1.9 (H)2.6 ( s)-2 (uppr)-6 (es)8.9 (s)-2 (i)2.6 (on or)5 ( )11.2 (T)-10.5 (S)1.9 (H)2.6 ( s)8.9 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (at)-6.6 (i)2.7 (on\))-6 ( )11.3 (and abs)-2 (enc)-2 (e)10.6 ( o)10.5 (f)-6.6 ( )]TJ 0.002 Tw 0 -1.37 Td [(ant)-6.6 (i)]TJ 0 Tc 0 Tw 1.609 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(Tg)-11.2 ( an)10.6 (t)-6.7 (i)2.7 (bodi)2.6 (es)-2 (.)]TJ 0 Tc 0 Tw 6.96 -0 0 6.96 495.6 426.84 Tm (3)Tj 11.04 -0 0 11.04 499.44 422.88 Tm ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(P)2 (at)-6.6 (i)2.6 (e)10.5 (nt)-6.6 (s)-2 ( t)-6.7 (r)-5.9 (ea)10.6 (t)-6.6 (ed )-10.7 (w)13.5 (i)2.7 (t)-6.7 (h )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 605.28 426.84 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 616.8 422.88 Tm [(I)-6.6 ( abl)2.6 (at)-6.7 (i)2.7 (on m)-6 (ay)8.8 ( be )11.3 (f)-6.6 (ol)2.6 (l)2.6 (ow)13.5 (ed )-10.5 (w)13.5 (i)2.6 (t)-6.6 (h )]TJ -19.185 -1.38 Td [(uns)-2 (t)-6.6 (i)2.6 (m)-5.9 (ul)2.6 (at)-6.6 (ed)10.5 ( )11.3 (Tg)-11.2 ( annual)2.6 (l)2.6 (y)8.9 ( and w)13.5 (i)2.6 (t)-6.6 (h per)-5.9 (i)2.6 (odi)2.6 (c)-2 ( nec)8.9 (k)-2 ( u)10.5 (l)2.6 (t)-6.6 (r)-6 (as)-2 (ound i)13.5 (f)-6.6 ( )11.3 (t)-6.7 (hey)8.8 ( hav)8.9 (e )]TJ 0 -1.37 Td [(neg)-11.2 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e ul)2.6 (t)-6.6 (r)-6 (as)-2 (ounds)8.9 (,)-6.6 ( s)8.8 (t)-6.6 (i)2.6 (m)-5.9 (ul)2.7 (at)-6.6 (ed )11.3 (Tg l)2.6 (es)-2 (s)-2 ( )11.2 (t)-6.5 (han)10.6 ( 2 n)10.5 (g/)-6.6 (m)-6 (L)10.5 ( )0.5 (\()-6 (w)13.5 (i)2.6 (t)-6.6 (h )]TJ 0.002 Tw [(ne)10.5 (g)-11.2 (at)-6.6 (i)2.6 (v)8.9 (e )]TJ 0 -1.38 Td [(ant)-6.6 (i)]TJ 0 Tc 0 Tw 1.609 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(Tg)-11.2 ( an)10.6 (t)-6.7 (i)2.7 (bod)]TJ -0.005 Tc 0.005 Tw [(ie)-3.3 (s)-5 (\))-9 (,)]TJ 0 Tc 0 Tw 6.598 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(and )11.2 (neg)-11.2 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e R)2.6 (A)1.9 (I)-6.6 ( i)2.6 (m)-5.9 (a)10.5 (g)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( )11.3 (\()-6 (i)13.5 (f)-17.5 ( )11.3 (per)4.9 (f)-17.5 (o)10.5 (r)-5.9 (m)-6 (ed)10.5 (\))-6 (.)4.3 ( H)2.6 (ow)13.4 (ev)8.9 (er)-5.9 (,)-6.6 ( i)2.6 (f)-6.6 ( )]TJ -8.815 -1.37 Td [(t)-6.6 (hey)8.9 ( hav)8.8 (e a c)-1.9 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( s)-2 (ugges)-2 (t)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( r)-5.9 (e)10.5 (c)-2 (ur)5 (r)-6 (ent)4.3 ( di)2.6 (s)-2 (ea)10.5 (s)-2 (e,)-6.7 ( )11.3 (t)-6.6 (hen )11.2 (T)-10.5 (S)1.9 (H)]TJ 0 Tc 0 Tw 27.37 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.326 0 Td [(s)-2 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (a)10.5 (t)-6.6 (ed )]TJ 0.007 Tw -27.696 -1.38 Td [(t)-6.6 (es)-2.1 (t)-6.6 (i)2.7 (n)10.5 (g)-11.2 ( )11.2 (\()-5.9 (or)4.9 ( ot)-6.6 (he)10.6 (r)-6 ( i)13.5 (m)-6 (a)10.5 (g)-11.2 (i)2.6 (ng\))5 ( m)-5.9 (ay)8.8 ( be )11.3 (c)-2 (ons)-2 (i)2.6 (der)-5.9 (ed.)4.2 ( A)2 ( )11.2 (s)8.9 (ubgr)-6 (oup o)10.5 (f)-6.6 ( pa)10.6 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( at)4.2 ( )]TJ 0 -1.37 Td [(l)2.6 (o)-11.2 (w)13.5 ( r)-6 (i)2.6 (s)-2 (k)-2 ( \()-5.9 (e)10.5 (g,)-6.6 ( )11.3 (m)-6 (i)2.7 (c)-2 (r)-6 (opapi)2.6 (l)2.6 (l)2.7 (ar)-6 (y)8.9 ( c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (as)8.9 ( en)10.6 (t)-6.6 (i)2.6 (r)-6 (el)2.6 (y)8.8 ( c)-2 (o)]TJ [(n)10.5 (f)-17.5 (i)2.6 (ned t)-6.6 (o)10.5 ( t)-6.6 (he)10.5 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.38 Td [(g)-11.2 (l)2.6 (and\))4.9 ( m)-6 (ay)8.8 ( onl)2.6 (y)8.9 ( r)-5.9 (e)10.5 (q)-11.2 (ui)2.6 (r)-5.9 (e)10.5 ( )11.3 (per)-6 (i)2.6 (odi)2.6 (c)-2 ( nec)8.9 (k)-12.9 ( ul)13.5 (t)-6.6 (r)-6 (as)-2 (ound)10.6 ( )11.2 (f)-6.6 (ol)2.6 (l)2.6 (ow)]TJ 0 Tc 0 Tw 24.293 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up \()-6 (w)13.5 (i)2.6 (t)-6.6 (hout)-6.6 ( )]TJ -0.004 Tw -24.63 -1.37 Td [(s)-2 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (at)-6.6 (ed)10.5 ( Tg)-11.2 ( )-10.6 (o)10.5 (r)-6 ( f)-6.6 (ol)2.6 (l)2.6 (ow)]TJ 0 Tc 0 Tw 9.957 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(u)-11.2 (p w)13.5 (hol)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 4.326 0 Td [(body)8.8 ( i)2.6 (m)-5.9 (ag)-11.2 (i)2.6 (ng\))-5.9 ( a)10.5 (s)-2 ( l)2.6 (ong as)8.9 ( t)-6.6 (hei)2.6 (r)4.9 ( bas)-2 (al)2.6 ( )11.2 (Tg )]TJ -14.62 -1.38 Td [(r)-6 (em)-6 (ai)2.6 (ns)-2 ( l)2.6 (ow)13.5 ( \()-6 (s)-2 (ee)10.5 ( )]TJ /TT2 1 Tf [(S)2 (ur)-5.9 (v)-2 (ei)2.6 (l)2.6 (l)2.7 (anc)-2 (e and M)4.9 (ai)2.6 (nt)-6.6 (enanc)-2 (e)]TJ /TT0 1 Tf 0 Tc 0 Tw 21.163 0 Td ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(i)10.5 (n)-3.4 ( t)-9.6 (h)-3.4 (e)7.6 ( NCCN G)-9.6 (u)-3.3 (id)-3.4 (e)-3.3 (lin)-3.4 (e)-3.3 (s)-5 ( )]TJ -0.002 Tc 0.007 Tw -21.446 -1.37 Td [(f)-6.6 (or)5 ( P)1.9 (api)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( [)-6.6 (T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d])-6.6 ( )]TJ [(C)2.6 (a)10.6 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a\))4.9 (.)-6.6 ( N)2.6 (o)10.6 (t)-6.7 (e )11.3 (t)-6.6 (hat)4.2 ( )11.3 (Tg s)8.9 (houl)2.6 (d be m)-5.9 (ea)10.5 (s)-2 (ur)-6 (ed)10.5 ( us)-2 (i)2.6 (ng )]TJ 0 -1.38 Td [(t)-6.6 (he s)-2 (a)10.5 (m)-5.9 (e l)2.6 (abo)10.6 (r)-6 (at)-6.5 (o)10.5 (r)-6 (y)8.9 ( and )11.3 (t)-6.6 (he s)-2 (a)10.5 (m)-5.9 (e a)10.5 (s)-2 (s)-2 (ay)8.9 (,)-6.6 ( bec)-2 (aus)8.8 (e )11.3 (Tg)-11.3 ( l)2.6 (ev)8.9 (el)2.6 (s)-2 ( v)8.9 (ar)-6 (y)8.9 ( )-10.5 (w)13.5 (i)2.6 (del)-8.3 (y)8.9 ( )]TJ 0 -1.37 Td [(bet)-6.6 (w)13.5 (een l)2.6 (abor)-5.9 (at)-6.6 (or)-5.9 (i)2.6 (es)-1.9 (.)]TJ 0 Tc 0 Tw 6.96 -0 0 6.96 510.36 244.68 Tm (3)Tj 11.04 -0 0 11.04 514.08 240.72 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(P)2 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h c)-2 (l)2.7 (i)2.6 (ni)2.6 (c)-2 (al)2.6 (l)2.6 (y)8.9 ( s)-2 (i)2.6 (g)-11.2 (ni)2.6 (f)-17.5 (i)2.7 (c)-2 (an)10.5 (t)-6.6 ( )11.3 (r)-6 (es)-2 (i)2.6 (dual)2.6 ( di)2.6 (s)-2 (eas)-2 (e )]TJ -10.163 -1.38 Td [(c)-2 (an t)-6.6 (y)8.9 (pi)2.6 (c)-2 (al)2.6 (l)2.6 (y)8.9 ( be i)2.6 (dent)-6.6 (i)2.6 (f)-17.4 (i)2.6 (ed)10.5 ( by)8.9 ( t)-6.6 (he )11.2 (t)-6.6 (r)-5.9 (end)10.5 ( i)2.6 (n )11.2 (Tg l)2.6 (ev)8.9 (el)2.6 (s)-12.9 ( ov)8.9 (er)-6 ( t)-6.6 (i)13.5 (m)-6 (e.)]TJ 0 Tc 0 Tw 6.96 -0 0 6.96 698.64 229.44 Tm (3)Tj 11.04 -0 0 11.04 702.36 225.48 Tm ( )Tj EMC /P <>BDC -0.005 Tc -0.001 Tw -26.935 -2.37 Td [(RA)-1 (I)-9.7 ( )-10.6 (im)-8.9 (a)7.5 (g)-14.2 (in)7.5 (g)-14.2 ( \()1.9 (T)-13.5 (S)-1.1 (H)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 8.37 0 Td [(s)-2 (t)-6.6 (i)13.5 (m)-6 (ul)2.6 (at)-6.6 (ed [)-6.6 (dur)-6 (i)2.7 (n)10.5 (g)-11.3 ( )-10.5 (ei)13.5 (t)-6.6 (her)4.9 ( T)-10.6 (S)2 (H)2.6 ( )-10.6 (s)8.8 (uppr)-6 (es)-2 (s)-2 (i)2.6 (on )-10.6 (o)10.5 (r)-5.9 ( T)-10.5 (S)1.9 (H)2.6 ( )]TJ 0.007 Tw -8.37 -1.37 Td [(s)-2 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (at)-6.6 (i)2.6 (on])4.2 (\))-5.9 ( )11.3 (c)-2 (an be)10.5 ( c)-2 (ons)8.9 (i)2.6 (der)-5.9 (ed i)2.6 (n pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 (s)-2 ( a)10.5 (t)-6.6 ( )]TJ -0.016 Tc 0.016 Tw [(h)-14.3 (i)-0.6 (g)-25.2 (h)-3.5 ( )]TJ 0.004 Tc -0.01 Tw 22.163 0 Td [(ri)8.6 (s)14.9 (k)-6.9 ( f)-0.6 (o)16.5 (r )]TJ -0.013 Tc 0.018 Tw 3.272 0 Td [(p)-11.3 (er)-17 (s)-13 (i)-8.4 (s)-13 (t)-17.6 (e)-11.3 (nt)-17.6 ( or)-17 ( )]TJ -0.002 Tc 0.007 Tw -25.435 -1.38 Td [(r)-6 (ec)-2 (ur)5 (r)-6 (ent)4.3 ( di)2.6 (s)-2 (eas)-1.9 (e)]TJ 0 Tc 0 Tw (,)Tj 7.978 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(di)2.6 (s)-2 (t)-6.6 (an)10.5 (t)-6.6 ( )11.3 (m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-1.9 (es)8.9 (,)-6.6 ( o)10.5 (r)-6 ( di)2.6 (s)-2 (eas)-2 (e)]TJ 0 Tc 0 Tw 13.457 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(s)-2 (pec)-2 (i)13.5 (f)-17.5 (i)2.6 (c)-2 ( m)-6 (or)4.9 (t)-6.6 (al)2.7 (i)2.6 (t)-6.6 (y)8.8 (;)]TJ 0 Tc 0 Tw 7.641 0 Td ( )Tj -0.002 Tc 0.007 Tw -29.696 -1.37 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h pr)-6 (ev)8.9 (i)2.6 (ous)-2 ( R)13.4 (A)2 (I)]TJ 0 Tc 0 Tw 11.522 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(av)8.8 (i)2.6 (d m)-6 (et)-6.6 (a)10.5 (s)-2 (t)-6.6 (as)-2 (es)8.9 (;)4.2 ( or)4.9 ( p)10.5 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.4 (i)2.6 (t)-6.6 (h abnor)4.9 (m)-5.9 (al)2.6 ( )11.3 (Tg )]TJ -11.859 -1.38 Td [(l)2.6 (ev)8.8 (e)-11.2 (l)2.6 (s)-2 (,)-6.6 ( s)-2 (t)-6.6 (abl)2.6 (e)10.6 ( or)4.9 ( i)2.6 (nc)-2 (r)-6 (eas)-2 (i)13.5 (ng ant)-6.6 (i)]TJ 0 Tc 0 Tw 13.63 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(Tg ant)-6.7 (i)2.7 (bodi)2.6 (es)-2 (,)4.2 ( or)4.9 ( )11.3 (abnor)-6 (m)-5.9 (al)2.6 ( ul)13.5 (t)-6.6 (r)-6 (as)-2 (ound)10.6 ( )]TJ -13.957 -1.37 Td [(r)-6 (es)-2 (ul)2.7 (t)-6.6 (s)8.8 (.)-6.6 ( )11.3 (I)-6.6 (n pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( s)-2 (el)2.6 (ec)-2 (t)4.3 (ed )11.3 (f)-17.5 (o)10.6 (r)-6 ( )11.3 (m)-6 (oni)2.6 (t)-6.6 (or)-6 (i)2.6 (n)10.6 (g w)13.5 (i)2.6 (t)-6.6 (h R)2.6 (A)2 (I)-6.6 ( i)2.6 (m)-6 (a)10.6 (g)-11.2 (i)]TJ -0.016 Tc 0.021 Tw 25.098 0 Td [(n)-3.5 (g)-25.2 ( i)-0.6 (t)-20.6 ( i)-11.4 (s)-16 ( )]TJ -0.002 Tc 0.007 Tw -25.098 -1.38 Td [(r)-6 (ec)-2 (om)5 (m)-6 (ended)10.5 ( ev)8.9 (er)-5.9 (y)8.8 ( 12 t)4.3 (o )0.5 (24 )11.2 (m)-5.9 (ont)-6.6 (hs)8.9 ( un)10.5 (t)-6.6 (i)2.7 (l)2.6 ( no c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 (l)2.6 (y)8.9 ( s)-2 (i)2.6 (g)-11.2 (ni)2.6 (f)-17.4 (i)2.6 (c)-2 (ant)4.3 ( )]TJ 0 -1.37 Td [(r)-6 (es)-2 (pons)-2 (e i)2.6 (s)8.9 ( s)-2 (een )11.3 (t)-6.6 (o)10.5 ( R)2.6 (A)2 (I)-6.6 ( )11.2 (t)-6.5 (r)-6 (ea)10.6 (t)-6.7 (m)-5.9 (en)10.5 (t)-6.6 ( i)2.6 (n pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (i)2.7 (t)-6.7 (h i)2.6 (odi)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 25.207 0 Td [(r)-6 (es)-2 (pons)-2 (i)2.6 (v)8.8 (e )]TJ 0.007 Tw -25.207 -1.38 Td [(t)-6.6 (um)-5.9 (o)10.5 (r)-5.9 (s)-2 ( and)10.5 ( det)4.2 (ec)-2 (t)-6.6 (abl)2.6 (e )11.2 (Tg,)-6.6 ( di)2.7 (s)-2.1 (t)-6.6 (an)10.5 (t)4.3 ( m)-6 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (a)10.5 (s)-2 (es)-2 (,)4.2 ( or)4.9 ( s)-2 (o)10.5 (f)-6.6 (t)-6.6 ( )11.3 (t)-6.7 (i)2.6 (s)-2 (s)-2 (ue i)2.6 (nv)8.9 (as)-2.1 (i)2.7 (on on )]TJ -0.005 Tc 0.01 Tw 0 -1.37 Td [(in)-3.3 (it)-9.7 (ia)-3.3 (l s)-5 (t)-9.6 (a)-3.4 (g)-14.2 (in)7.5 (g)-3.3 (.)-9.7 ( No)-3.3 (n)]TJ 0 Tc 0 Tw 8.152 0 Td (-)Tj -0.005 Tc 0.01 Tw 0.337 0 Td [(RA)9.8 (I)-9.6 ( i)10.5 (m)-9 (a)7.5 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For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 811 0 obj 245 endobj %% Contents for page 88 %% Original object ID: 176 0 812 0 obj << /Length 813 0 R >> stream q endstream endobj 813 0 obj 2 endobj %% Contents for page 88 %% Original object ID: 11420 0 814 0 obj << /Length 815 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 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(.)]TJ 0 Tc 0 Tw 4.989 0 Td ( )Tj -0.005 Tc 0.005 Tw 0.283 0 Td [(Hig)-14.2 (h)]TJ 0 Tc 0 Tw 2.043 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(r)-6 (i)2.7 (s)8.8 (k)-2 ( )11.3 (f)-17.5 (ac)8.8 (t)4.3 (or)-5.9 (s)-2 ( i)2.6 (nc)-1.9 (l)2.6 (ude i)2.6 (nc)-2 (o)10.5 (m)-6 (pl)2.6 (et)-6.6 (e )11.3 (t)-6.6 (u)10.5 (m)-6 (or)4.9 ( r)-5.9 (es)-2 (ec)8.8 (t)-6.6 (i)2.6 (on,)4.3 ( )]TJ -0.004 Tw -7.652 -1.37 Td [(m)-6 (ac)-2 (r)-6 (os)8.9 (c)-2 (opi)2.6 (c)-2 ( t)-6.5 (um)-6 (o)10.6 (r)]TJ 0 Tc 0 Tw 8.424 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (nv)8.8 (as)-2 (i)2.6 (on,)-6.6 ( and di)2.6 (s)8.9 (t)-6.6 (ant)4.2 ( m)-5.9 (e)10.5 (t)-6.6 (as)8.9 (t)-6.6 (as)8.8 (es)]TJ /TT1 1 Tf 0 Tc 0 Tw 14.446 0 Td ( )Tj /TT0 1 Tf -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (n pat)-6.7 (i)2.7 (en)10.5 (t)-6.6 (s)-2 ( a)10.5 (t)-6.6 ( hi)13.5 (g)-11.2 (h)10.5 ( )]TJ -23.435 -1.38 Td [(r)-6 (i)2.7 (s)-2 (k)-2 ( )11.2 (f)-6.6 (or)4.9 ( per)-6 (s)-2 (i)2.6 (s)8.9 (t)-6.6 (ent)4.3 ( or)4.9 ( r)-5.9 (ec)-2 (u)10.6 (r)-6 (r)-5.9 (en)10.5 (t)-6.6 ( di)2.6 (s)-2 (eas)-2 (e)10.5 (,)-6.6 ( di)2.6 (s)-2 (t)-6.6 (an)10.5 (t)4.3 ( m)-6 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (as)-2 (e)10.6 (s)-2 (,)4.2 ( or)4.9 ( di)2.6 (s)-2 (eas)-2 (e)]TJ 0 Tc 0 Tw (-)Tj 0.005 Tw 0 -1.37 Td [(sp)1.7 (e)1.6 (ci)15.5 (f)-15.5 (i)4.6 (c m)-3.9 (o)12.5 (r)-4 (t)6.3 (a)1.6 (l)4.6 (i)4.6 (t)-4.6 (y)10.9 ( \()-3.9 (se)]TJ -0.002 Tc 0.002 Tw 9.033 0 Td (e )Tj /TT2 1 Tf 0.007 Tw 0.837 0 Td [(C)13.5 (ons)-2 (i)2.6 (der)-6 (at)-6.6 (i)2.6 (on )11.3 (f)-6.6 (or)4.9 ( I)-6.6 (ni)2.6 (t)-6.6 (i)2.6 (al)2.7 ( P)2 (o)10.5 (s)-2 (t)-6.6 (oper)-6 (a)10.6 (t)-6.7 (i)2.6 (v)-2 (e R)2.6 (A)2 (I)4.2 ( Ther)-5.9 (ap)10.6 (y)]TJ /TT0 1 Tf 0 Tc 0 Tw 22.424 0 Td ( )Tj -0.002 Tc 0.007 Tw -32.293 -1.38 Td [(i)2.6 (n t)-6.6 (he N)2.6 (C)2.6 (C)2.6 (N)2.6 ( )11.2 (G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( f)-6.6 (or)4.9 ( P)2 (api)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( [)-6.7 (T)-10.5 (hy)8.9 (r)-5.9 (oi)2.6 (d])-6.6 ( C)2.6 (a)10.5 (r)-6 (c)-2 (i)2.6 (nom)-6 (a\))]TJ 0 Tc 0 Tw 25.707 0 Td (.)Tj 6.96 -0 0 6.96 310.44 441.96 Tm (3)Tj /TT1 1 Tf 11.04 -0 0 11.04 314.28 438 Tm ( )Tj 0.272 0 Td ( )Tj EMC /H2 <>BDC 0.009 Tc 0.007 Tw -26.609 -2.391 Td [(R)2.7 (ecur)-4.1 (r)6.7 (ent)5 ( )0.6 (D)13.6 (i)-6.5 (sea)10.6 (se )]TJ 0 Tc 0 Tw 9.196 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw -9.196 -1.696 Td [(T)-10.6 (he)10.5 ( N)2.6 (C)2.6 (C)2.6 (N)2.6 ( P)2 (anel)2.6 ( agr)-6 (e)]TJ [(es)8.9 ( t)-6.6 (ha)10.6 (t)-6.7 ( )0.5 (s)-2.1 (u)10.6 (r)4.9 (g)-11.2 (er)-5.9 (y)8.8 ( i)2.6 (s)-2 ( )11.3 (t)-6.6 (he p)10.5 (r)-5.9 (e)10.5 (f)-17.5 (e)10.5 (r)5 (r)-6 (ed )11.3 (t)-6.6 (her)-6 (apy)8.9 ( )11.3 (f)-17.5 (o)10.5 (r)-6 ( )]TJ 0 -1.38 Td [(l)2.6 (oc)-2 (or)-5.9 (eg)-11.2 (i)2.6 (onal)2.6 ( )11.2 (r)-5.9 (ec)-2 (ur)4.9 (r)-6 (ent)4.2 ( di)13.5 (s)-2 (eas)-2 (e i)13.5 (f)-6.6 ( t)-6.6 (he)10.6 ( t)-6.6 (u)10.5 (m)-5.9 (or)4.9 ( i)2.6 (s)-2 ( )11.2 (r)-5.9 (es)8.9 (ec)-2 (t)-6.6 (abl)2.6 (e \()4.9 (s)-2 (ee )]TJ /TT2 1 Tf -0.013 Tc 0.013 Tw [(R)-8.4 (e)-11.3 (c)-13 (ur)-16.9 (r)-17 (e)-11.3 (nt)-17.6 ( )]TJ -0.005 Tc 0.005 Tw 0 -1.37 Td [(Dis)-5 (e)-3.3 (a)-3.4 (s)-5 (e)]TJ /TT0 1 Tf 0 Tc 0 Tw 3.598 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (n t)-6.6 (he)10.5 ( N)2.6 (C)2.7 (C)2.6 (N)2.6 ( P)1.9 (api)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( [)-6.6 (T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d])-6.6 ( C)2.6 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (a al)13.4 (g)-11.2 (or)-6 (i)2.6 (t)4.3 (hm)5 (\))-6 (.)4.3 ( C)2.6 (er)-5.9 (v)8.8 (i)2.6 (c)-2 (al)2.6 ( )]TJ -3.88 -1.38 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2.1 (ound,)4.2 ( i)2.6 (nc)-2 (l)2.6 (udi)2.6 (ng t)-6.6 (he)10.5 ( )11.2 (c)-2 (ent)-6.7 (r)-5.9 (al)2.7 ( and)10.5 ( l)2.6 (at)-6.6 (e)10.6 (r)-6 (al)2.6 ( c)-2 (o)10.5 (m)-6 (p)10.5 (ar)-5.9 (t)4.2 (m)-6 (ent)-6.6 (s)8.8 (,)-6.6 ( i)2.6 (s)8.9 ( t)-6.6 (he)10.6 ( )]TJ -0.005 Tc 0.005 Tw [(p)-3.4 (r)-9 (in)-3.3 (c)-5 (ip)]TJ -0.002 Tc 0.002 Tw 31.739 0 Td (al)Tj 0 Tc 0 Tw 0.772 0 Td ( )Tj -0.002 Tc 0.007 Tw -32.511 -1.37 Td [(i)2.6 (m)-5.9 (ag)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( )11.3 (m)-6 (odal)2.6 (i)2.6 (t)-6.6 (y)8.8 ( )0.5 (w)13.4 (hen l)2.6 (oc)-2 (or)-6 (e)10.6 (g)-11.3 (i)2.7 (onal)2.6 ( r)-5.9 (ec)-2 (u)10.6 (r)-6 (r)-6 (enc)-2 (e)10.5 ( i)13.4 (s)-2 ( )0.5 (s)-2 (us)-2 (pec)8.9 (t)-6.6 (ed.)]TJ 0 Tc 0 Tw 6.96 -0 0 6.96 320.76 336.12 Tm (3)Tj 11.04 -0 0 11.04 324.6 332.16 Tm ( )Tj -0.005 Tc 0.005 Tw -27.272 -1.38 Td [(Cr)-9 (o)-3.3 (s)-5 (s)]TJ 0 Tc 0 Tw 2.609 0 Td (-)Tj -0.005 Tc -0.001 Tw 0.337 0 Td [(s)-5 (e)-3.4 (c)5.9 (t)-9.6 (io)-3.4 (n)-3.3 (a)-3.4 (l )-10.7 (im)-8.9 (a)7.5 (g)-14.3 (in)7.5 (g)-14.2 ( wit)-9.6 (h)-3.3 ( )]TJ -0.002 Tc 0.007 Tw 10.022 0 Td [(C)2.6 (T or)4.9 ( M)15.8 (R)2.6 (I)-6.6 ( m)-5.9 (ay)8.9 ( al)2.6 (s)-2 (o)10.5 ( be v)8.9 (al)2.6 (uabl)2.6 (e)]TJ 0 Tc 0 Tw ( )Tj -0.007 Tc 0.007 Tw 14.489 0 Td [(f)-22.5 (o)-5.3 (r )]TJ -0.002 Tc -27.457 -1.37 Td [(ev)8.8 (al)2.6 (uat)-6.6 (i)2.6 (on and s)-2 (ur)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( p)10.5 (l)2.6 (anni)2.6 (ng)]TJ 14.239 0 Td [(,)-6.6 ( e)10.5 (s)-2 (pec)-2 (i)2.6 (al)2.6 (l)2.6 (y)8.9 ( )-10.5 (w)13.5 (hen r)-5.9 (el)2.6 (i)2.7 (abl)2.6 (e hi)2.6 (g)-11.2 (h)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 13.565 0 Td [(r)-6 (es)-2 (ol)2.7 (ut)-6.6 (i)2.6 (on )]TJ 0.007 Tw -27.804 -1.38 Td [(di)2.6 (ag)-11.2 (nos)-2 (t)-6.6 (i)2.6 (c)8.9 ( ul)2.6 (t)-6.6 (r)-5.9 (a)10.5 (s)-2 (ound i)2.6 (s)-2 ( )11.3 (unav)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e and/)-6.6 (or)-6 ( )11.3 (t)-6.6 (her)-6 (e)10.6 ( )11.2 (i)2.6 (s)-2 ( s)-1.9 (us)-2 (pi)2.7 (c)-2 (i)2.6 (on o)10.5 (f)-6.6 ( i)2.6 (nv)8.8 (as)-2 (i)2.6 (on )]TJ 0 -1.37 Td [(i)2.6 (nt)-6.6 (o t)-6.6 (he)10.6 ( aer)-6 (odi)13.5 (g)-11.2 (es)8.9 (t)-6.6 (i)2.6 (v)8.9 (e t)-6.6 (r)-5.9 (a)10.5 (c)-2 (t)-6.6 (.)4.3 ( I)-6.6 (n)10.6 ( m)-6 (o)10.5 (s)-2 (t)4.3 ( c)-2 (as)-2 (es)8.9 (,)-6.6 ( l)2.6 (es)-2 (i)2.6 (on)10.5 (s)-2 ( s)-2 (us)-2.1 (pi)2.6 (c)-2 (i)2.6 (ous)-2 ( )11.3 (f)-6.6 (or)5 ( )]TJ -0.005 Tc 0.005 Tw 0 -1.38 Td [(lo)-3.3 (c)]TJ -0.002 Tc 0.007 Tw 1.272 0 Td [(or)-6 (eg)-11.2 (i)2.7 (onal)2.6 ( )11.3 (r)-6 (ec)-2 (ur)5 (r)-6 (enc)-2 (e)10.5 (,)-6.6 ( )11.3 (w)13.5 (h)-11.3 (i)2.7 (c)-2 (h ar)-5.9 (e a)10.6 (m)-6 (enabl)2.6 (e )11.3 (t)-6.6 (o n)10.5 (eedl)2.6 (e bi)2.6 (ops)-2 (y)8.9 (,)-6.6 ( s)-2 (houl)2.6 (d be )]TJ -1.272 -1.37 Td [(i)2.6 (nt)-6.6 (er)-5.9 (r)-6 (o)10.5 (g)-11.2 (a)10.5 (t)-6.6 (ed w)13.5 (i)2.6 (t)-6.6 (h FN)2.6 (A)1.9 ( bi)13.5 (ops)-2 (y)8.8 ( bef)-17.4 (o)10.5 (r)-6 (e )11.3 (s)-2.1 (ur)4.9 (g)-11.2 (e)10.5 (r)-5.9 (y)8.8 (.)-6.6 ( )]TJ 0.002 Tw 20.043 0 Td (Tg)Tj 0 Tc 0 Tw 1.174 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(w)13.5 (as)-2 (hout)-6.6 ( as)-2 (s)-2 (ay)8.9 ( m)-5.9 (ay)8.8 ( be a)10.6 ( )]TJ -21.489 -1.38 Td [(us)-2 (e)10.5 (f)-17.5 (ul)2.6 ( ad)10.5 (j)-8.2 (unc)-2 (t)4.2 ( t)-6.6 (o)10.6 ( FN)2.6 (A)1.9 ( bi)13.4 (ops)-2 (y)8.8 ( i)2.6 (n t)-6.6 (hes)-2 (e c)8.9 (as)-2 (es)]TJ -0.005 Tc 0.01 Tw 19.337 0 Td [(,)1.3 ( p)-3.3 (a)-3.4 (r)1.9 (t)1.3 (ic)-5 (u)-3.4 (la)-3.3 (r)-9 (ly)5.9 ( if)-20.5 ( c)-5 (y)5.9 (t)-9.7 (o)-3.3 (lo)-3.4 (g)-14.2 (y)5.9 ( is)5.9 ( )]TJ -0.002 Tc 0.002 Tw -19.337 -1.37 Td [(neg)-11.2 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e)]TJ 0 Tc 0 Tw (.)Tj 4.043 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -4.043 -2.37 Td [(C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)-8.2 (l)-8.3 (y)8.9 ( s)-2 (i)2.6 (g)-11.2 (ni)13.5 (f)-17.5 (i)2.7 (c)-2 (ant)4.2 ( nod)10.5 (al)2.6 ( r)-6 (ec)-2 (u)]TJ [(r)4.9 (r)-6 (enc)-2 (e)10.5 ( )0.5 (i)2.5 (n a p)10.5 (r)-6 (ev)8.8 (i)2.7 (ous)-2 (l)2.6 (y)8.8 ( undi)2.6 (s)-2 (s)-2 (ec)-2 (t)-6.6 (ed nodal)2.6 ( )]TJ 0 -1.38 Td [(bas)-2 (i)2.6 (n s)-2 (houl)2.6 (d be )11.3 (t)-6.6 (r)-6 (ea)10.6 (t)-6.6 (ed )11.2 (w)2.6 (i)2.6 (t)-6.6 (h a )11.2 (f)-6.6 (or)4.9 (m)-6 (al)2.6 ( c)-2 (o)10.5 (m)-6 (par)5 (t)-6.6 (m)-6 (e)10.5 (nt)-6.6 (al)2.6 ( r)-5.9 (es)-2 (e)10.5 (c)-2 (t)-6.6 (i)2.7 (on.)]TJ 0 Tc 0 Tw 6.96 -0 0 6.96 330.12 173.28 Tm (3)Tj 11.04 -0 0 11.04 333.96 169.32 Tm ( )Tj -0.002 Tc -0.004 Tw 0.272 0 Td [(I)-6.6 (n t)-6.6 (he)10.5 ( )]TJ 0.007 Tw -28.391 -1.37 Td [(c)-2 (ent)-6.6 (r)-6 (al)2.6 ( ne)10.5 (c)8.9 (k)-12.9 (,)4.2 ( t)-6.6 (hi)2.6 (s)8.9 ( i)2.6 (s)-2 ( us)-2 (ua)10.5 (l)2.6 (l)-8.2 (y)8.8 ( ac)-2 (hi)2.6 (ev)8.9 (ed t)-6.6 (hr)-5.9 (ou)10.5 (g)-11.2 (h a)10.5 ( un)10.6 (i)2.6 (l)2.6 (at)-6.6 (er)-6 (al)2.6 ( l)2.6 (ev)8.9 (el)2.6 ( V)1.9 (I)-6.6 ( )]TJ 0 -1.38 Td [(di)2.6 (s)-2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (on and,)4.2 ( oc)-2 (c)-2 (a)10.5 (s)-2 (i)2.6 (onal)2.6 (l)-8.2 (y)8.8 (,)-6.6 ( a l)2.6 (ev)8.9 (el)2.7 ( V)1.9 (I)-6.6 (I)-6.6 ( di)2.7 (s)-2 (s)-2 (e)10.5 (c)-2 (t)-6.6 (i)2.6 (o)10.5 (n.)-6.6 ( )11.3 (I)-6.6 (n )11.2 (t)-6.6 (he l)2.6 (at)-6.6 (e)10.5 (r)-6 (al)2.6 ( )]TJ -0.004 Tw 0 -1.37 Td [(c)-2 (om)-6 (par)4.9 (t)-6.6 (m)-5.9 (e)10.5 (nt)4.3 (,)-6.6 ( )-10.6 (a)10.5 ( f)-17.5 (o)10.5 (r)-5.9 (m)-6 (al)2.6 ( m)5 (odi)2.6 (f)-17.5 (i)2.6 (ed r)-6 (adi)2.6 (c)-2 (al)2.6 ( )-10.6 (nec)8.9 (k)-2 ( )-10.6 (di)2.6 (s)-2 (s)8.9 (ec)-2 (t)-6.6 (i)2.6 (on)]TJ 0 Tc 0 Tw <97>Tj -0.002 Tc 0.007 Tw [(i)2.6 (nc)-2 (l)2.6 (udi)2.6 (ng)-11.2 ( l)2.6 (ev)8.9 (el)2.6 (s)-2 ( )]TJ 0.005 Tc 0 Tw 0 -1.38 Td [(II)11.3 (, )11.2 (II)11.3 (I,)11.2 ( IV)19.9 (, a)6.6 (n)6.7 (d)17.5 ( V)9 (b)]TJ 0 Tc 7.152 0 Td <97>Tj -0.002 Tc 0.007 Tw [(s)-2 (houl)2.6 (d)10.5 ( be pe)10.6 (r)4.9 (f)-17.5 (o)10.5 (r)-5.9 (m)-6 (e)]TJ [(d)10.5 (.)-6.6 ( E)2 (x)8.8 (t)-6.6 (endi)2.6 (n)10.5 (g )0.5 (t)-6.7 (he)10.5 ( di)2.6 (s)-2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (on)10.5 ( )11.3 (f)-17.5 (i)2.6 (el)2.6 (d i)2.6 (nt)-6.6 (o)10.5 ( )]TJ -7.152 -1.37 Td [(l)2.6 (ev)8.8 (e)-11.2 (l)2.6 (s)-2 ( I)-6.6 ( o)10.5 (r)-5.9 ( V)1.9 (a)10.6 ( m)-6 (ay)8.9 ( be)10.5 ( ne)10.5 (c)-2 (es)-2 (s)-2 (ar)-6 (y)8.9 ( w)13.5 (hen t)-6.6 (hes)-2 (e l)2.6 (ev)8.9 (el)2.6 (s)-2 ( ar)-5.9 (e )11.3 (c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 (l)-8.2 (y)8.8 ( i)2.6 (n)-11.2 (v)8.9 (ol)-8.3 (v)8.9 (ed.)-6.6 ( )]TJ 0 -1.38 Td [(S)2 (el)2.6 (ec)-2 (t)-6.6 (i)2.6 (v)8.8 (e di)2.6 (s)-2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (on o)10.6 (f)-6.7 ( i)2.7 (ndi)2.6 (v)-2 (i)2.6 (dual)2.6 ( nodal)2.6 ( m)-6 (et)-6.7 (as)8.9 (t)-6.6 (as)-2 (e)10.5 (s)-2 ( \()-5.9 (c)-2 (he)10.6 (r)-6 (r)-6 (y)8.9 ( pi)2.6 (c)8.9 (k)-12.9 (i)2.6 (n)10.5 (g)-11.2 (\))4.9 ( i)2.6 (s)-2 ( no)10.5 (t)-6.6 ( )]TJ 0 -1.37 Td [(c)-2 (ons)-2 (i)2.6 (der)-5.9 (ed ade)10.5 (q)-11.2 (ua)10.6 (t)-6.7 (e s)-2 (u)10.5 (r)4.9 (g)-11.2 (e)10.6 (r)-6 (y)8.9 ( )11.2 (f)-17.5 (or)4.9 ( nodal)2.6 ( di)2.6 (s)-2 (eas)-2 (e)10.5 ( i)2.6 (n a p)10.6 (r)-6 (ev)8.8 (i)2.6 (ous)-2 (l)-8.2 (y)8.9 ( )]TJ 0.002 Tw 0 -1.38 Td (undi)Tj -0.004 Tw 1.88 0 Td [(s)-2 (s)-2 (ec)-2.1 (t)-6.5 (ed f)-17.5 (i)2.7 (el)2.6 (d)10.5 (,)-6.6 ( )-10.6 (and)10.6 ( )-10.7 (i)2.7 (s)-2 ( not)-6.6 ( r)-6 (ec)-2 (om)5 (m)-6 (ended)10.5 ( )-10.6 (i)2.6 (n )-10.6 (t)-6.6 (he)10.6 ( N)2.6 (C)2.6 (C)2.6 (N)2.7 ( )]TJ 23.207 0 Td [(G)-6.6 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( f)-17.5 (or)4.9 ( )]TJ 0.007 Tw 9.467 42.217 Td [(T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d C)2.6 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (a.)4.3 ( C)2.6 (l)2.6 (i)2.6 (ni)-8.3 (c)-2 (al)2.6 (l)2.6 (y)8.8 ( s)-2 (i)2.7 (g)-11.3 (ni)2.6 (f)-17.5 (i)2.6 (c)-2 (ant)4.3 ( nodal)2.6 ( )11.3 (r)-6 (ec)8.8 (ur)-6 (r)-5.9 (enc)-2 (e)]TJ 0 Tc 0 Tw 25.37 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(det)-6.6 (ec)8.9 (t)-6.6 (ed)10.5 ( i)2.6 (n a )]TJ -25.652 -1.38 Td [(pr)-6 (ev)8.9 (i)2.6 (ous)-2 (l)-8.2 (y)8.9 ( di)2.6 (s)-2 (s)-2 (ec)-2 (t)-6.6 (ed nod)10.5 (al)2.6 ( bas)-2.1 (i)2.7 (n m)-5.9 (ay)8.9 ( be )11.3 (t)-6.7 (r)-5.9 (ea)10.5 (t)-6.6 (ed)10.5 ( )11.3 (w)2.6 (i)2.6 (t)-6.6 (h a )11.3 (m)-6 (or)-6 (e)10.5 ( )11.3 (f)-17.5 (oc)-2 (u)10.5 (s)-2 (ed )]TJ 0 -1.37 Td [(di)2.6 (s)-2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (on o)10.6 (f)-6.7 ( t)-6.6 (h)10.6 (e )11.3 (r)-6 (e)10.5 (g)-11.2 (i)2.6 (on c)8.9 (ont)-6.6 (ai)2.6 (ni)2.6 (ng)-11.2 ( )11.2 (t)-6.6 (he)10.5 ( m)-5.9 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (c)]TJ 0 Tc 0 Tw 21.554 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(di)2.6 (s)-2 (eas)-2 (e.)-6.6 ( Fo)10.5 (r)-5.9 ( ex)8.9 (am)-6 (pl)2.6 (e,)4.3 ( a )]TJ -21.826 -1.38 Td [(l)2.6 (ev)8.8 (e)-11.2 (l)2.6 ( I)-6.6 (I)4.3 ( r)-6 (ec)-2 (u)10.5 (r)-6 (r)-5.9 (enc)-2 (e)10.5 ( det)4.3 (ec)-2 (t)4.3 (ed i)2.6 (n a pa)10.5 (t)-6.6 (i)2.6 (ent)4.3 ( w)13.5 (ho under)-5.9 (w)13.5 (ent)-6.6 ( a )11.3 (m)-6 (odi)13.5 (f)-17.5 (i)2.7 (ed )0.5 (r)-6 (adi)2.6 (c)-2 (al)2.6 ( )]TJ 0 -1.37 Td [(nec)-2 (k)-2 ( di)2.6 (s)-2 (s)-2 (ec)8.9 (t)-6.6 (i)2.6 (on as)-2 ( p)10.6 (ar)4.9 (t)-6.6 ( o)10.6 (f)-6.7 ( )11.3 (t)-6.6 (he p)10.5 (r)-5.9 (i)2.6 (m)-6 (ar)-6 (y)8.9 ( )11.3 (t)-6.7 (r)-5.9 (ea)10.6 (t)-6.6 (m)-6 (en)10.5 (t)-6.6 ( )11.2 (m)-5.9 (ay)8.8 ( onl)2.6 (y)8.9 ( r)-6 (eq)-11.2 (ui)2.6 (r)-5.9 (e)10.5 ( s)-2 (el)2.6 (ec)-2 (t)-6.6 (i)2.6 (v)8.9 (e )]TJ 0 -1.38 Td [(di)2.6 (s)-2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (on o)10.6 (f)-6.7 ( l)2.6 (ev)8.9 (el)2.6 ( I)-6.6 (I)4.3 (.)-6.6 ( Li)13.5 (k)-12.9 (e)10.6 (w)2.6 (i)2.6 (s)-2 (e,)-6.6 ( a c)-2 (en)10.5 (t)-6.5 (r)-6 (al)13.5 ( nec)8.9 (k)-12.9 ( )11.3 (r)-6 (ec)-2 (u)10.5 (r)-5.9 (r)-6 (enc)-2 (e)10.5 ( det)-6.6 (ec)8.8 (t)-6.6 (ed)10.5 ( i)2.6 (n a )]TJ 0.002 Tw 0 -1.37 Td [(pat)-6.6 (i)2.6 (en)]TJ 0.007 Tw [(t)-6.6 ( w)13.5 (ho under)-6 (w)13.5 (ent)-6.6 ( a)10.5 ( c)-2 (ent)4.3 (r)-5.9 (al)2.6 ( nec)8.9 (k)-2 ( di)2.6 (s)-2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (on)10.5 ( )11.3 (as)-2 ( par)4.9 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (he p)10.5 (r)-5.9 (i)2.6 (m)-6 (a)10.5 (r)-5.9 (y)8.8 ( )]TJ 0 -1.38 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( )11.3 (m)-6 (ay)8.8 ( onl)2.6 (y)8.8 ( r)-5.9 (equi)2.6 (r)-5.9 (e a)10.6 ( )11.2 (f)-17.5 (oc)-2 (us)-2 (ed)10.5 ( r)-5.9 (e)10.5 (s)-2 (ec)-2 (t)-6.7 (i)2.7 (on)10.5 ( o)10.6 (f)-6.7 ( )0.5 (t)-6.7 (he)10.5 ( r)-5.9 (e)10.5 (g)-11.2 (i)2.6 (on o)10.5 (f)-6.6 ( )]TJ 0.002 Tw 0 -1.37 Td [(r)-6 (ec)-2 (ur)5 (r)-6 (enc)-2 (e.)]TJ 0 Tc 0 Tw 5.043 0 Td ( )Tj 0.272 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -5.315 -2.38 Td [(For)-6 ( un)10.6 (r)-6 (es)-2 (ec)-2 (t)-6.6 (abl)2.6 (e)10.6 ( l)2.6 (oc)-2 (or)-6 (e)10.5 (gi)2.6 (onal)2.6 ( r)-6 (ec)-2 (ur)-5.9 (r)-6 (en)10.5 (c)-2 (e,)4.3 ( R)2.6 (A)2 (I)-6.6 ( )11.2 (t)-6.6 (r)-5.9 (e)10.5 (at)-6.6 (m)-5.9 (en)10.6 (t)-6.7 ( and)10.6 ( E)1.9 (B)2 (R)2.6 (T or)5 ( )]TJ 0 -1.359 Td [(I)-6.6 (M)15.8 (R)2.6 (T)-10.6 ( ar)-6 (e)10.5 ( r)-5.9 (ec)-2 (o)10.5 (m)-5.9 (m)-6 (en)10.5 (ded )11.3 (i)2.6 (f)-6.7 ( t)-6.6 (he)10.5 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 554.28 355.2 Tm (131)Tj -0.005 Tc 0.01 Tw 11.04 -0 0 11.04 565.8 351.24 Tm [(I)-9.6 ( im)-9 (a)7.5 (g)-14.2 (in)-3.3 (g)-3.4 ( is)-5 ( p)-3.4 (o)]TJ 0.005 Tw 6.435 0 Td [(s)-5 (it)1.3 (iv)5.8 (e)-3.3 (.)]TJ EMC /Reference <>BDC /TT3 1 Tf 0 Tc 0 Tw 6.96 -0 0 6.96 664.8 355.2 Tm (296)Tj EMC /Span <>BDC (,)Tj EMC /Reference <>BDC 1.759 0 Td (372)Tj EMC /Span <>BDC /TT0 1 Tf 11.04 -0 0 11.04 687.48 351.24 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(Loc)-2 (al)2.6 ( t)-6.6 (her)-6 (api)2.6 (es)-2 (,)4.2 ( )]TJ -25.87 -1.391 Td [(s)-2 (uc)-2 (h as)8.9 ( et)-6.6 (hanol)2.6 ( abl)2.6 (a)10.5 (t)-6.6 (i)2.6 (on )11.3 (or)-5.9 ( R)2.6 (FA)2 (,)4.2 ( ar)-6 (e)10.5 ( al)2.6 (s)-2 (o an)10.5 ( opt)-6.6 (i)2.6 (o)10.6 (n i)13.5 (f)-17.5 ( av)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e.)-6.6 ( E)1.9 (B)2 (R)2.6 (T)-10.6 ( o)10.5 (r)-5.9 ( )]TJ 0 -1.37 Td [(I)-6.6 (M)15.8 (R)2.6 (T)-10.6 ( al)2.6 (one i)2.7 (s)-2 ( ano)10.5 (t)-6.6 (her)4.9 ( o)10.5 (pt)-6.6 (i)2.6 (on i)2.6 (n t)-6.6 (he)10.5 ( a)]TJ [(bs)-2 (enc)-2 (e)10.5 ( o)10.5 (f)-6.6 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 636.24 324.72 Tm (131)Tj -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 647.76 320.76 Tm [(I)-6.6 ( )-10.6 (upt)-6.6 (a)10.5 (k)-12.9 (e)10.6 ( f)-17.4 (o)10.5 (r)-6 ( s)-2 (el)2.6 (ec)-2 (t)-6.6 ( )]TJ 0.007 Tw -21.989 -1.38 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( no)10.6 (t)4.2 ( r)-5.9 (es)-1.9 (pons)-2 (i)2.6 (v)8.9 (e t)4.3 (o ot)-6.6 (he)10.6 (r)-6 ( )11.3 (t)-6.6 (her)-6 (api)2.6 (es)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 609.96 309.48 Tm [(306,)-1.8 (3)-17 (87)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 635.04 305.52 Tm ( )Tj -0.002 Tc 0.007 Tw 0.293 0 Td [(W)-25.4 (h)10.5 (e)10.6 (n )11.3 (r)-6 (ec)-2 (ur)4.9 (r)-5.9 (ent)4.2 ( di)2.6 (s)-2 (eas)-2 (e i)13.5 (s)-2 ( )]TJ -21.13 -1.37 Td [(s)-2 (us)-2 (pec)-2 (t)-6.6 (ed)10.5 ( bas)-2 (ed on)10.5 ( hi)13.4 (g)-11.2 (h)10.6 ( s)-2 (er)-6 (u)10.6 (m)]TJ 0 Tc 0 Tw 14.13 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(s)8.9 (t)-6.7 (i)2.7 (m)-6 (ul)2.6 (at)-6.6 (ed)10.5 ( )11.3 (Tg v)8.9 (al)-8.2 (ues)-2 ( \()4.9 (>)-5 (10 n)10.6 (g/)-6.6 (m)-5.9 (L)10.5 (\))-6 ( and)10.6 ( )]TJ -14.467 -1.38 Td [(neg)-11.2 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e i)]TJ 4.261 0 Td [(m)-6 (ag)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( )11.3 (s)-2 (t)-6.7 (udi)2.6 (es)8.9 ( \()-6 (i)2.7 (nc)-2 (l)2.6 (udi)2.6 (ng P)2 (E)1.9 (T )0.5 (s)-2.1 (c)-2 (ans)8.9 (\))-5.9 (,)4.2 ( )11.3 (R)2.6 (A)2 (I)-6.7 ( )0.5 (t)-6.7 (he)10.5 (r)-5.9 (apy)8.8 ( c)-2 (an )0.5 (be)10.5 ( )]TJ -4.261 -1.37 Td [(c)-2 (ons)-2 (i)2.6 (der)-5.9 (ed us)-2 (i)2.6 (n)10.6 (g)-11.3 ( an)10.5 ( e)10.5 (m)5 (pi)2.6 (r)-5.9 (i)2.6 (c)-2 ( )11.2 (f)-17.4 (i)2.6 (x)8.8 (ed dos)-2 (e o)10.5 (f)-6.6 ( 100)10.5 ( t)-6.6 (o)10.5 ( )11.3 (150 m)-6 (C)2.6 (i)2.6 ( o)10.6 (f)-6.7 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 700.44 264 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 711.96 260.04 Tm [(I)-6.6 ( \()4.9 (s)-2 (ee )]TJ /TT2 1 Tf -27.804 -1.38 Td [(R)2.6 (ec)-2 (ur)-5.9 (r)-6 (ent)4.3 ( D)2.6 (i)2.6 (s)-2 (eas)-2 (e)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.005 Tc 0.01 Tw 8.543 0 Td [(in)7.5 ( t)-9.6 (h)-3.4 (e)7.6 ( NCCN G)-9.6 (u)-3.3 (id)-3.4 (e)-3.3 (lin)-3.4 (e)-3.3 (s)-5 ( )11.2 (f)-20.5 (o)7.6 (r)-9 ( P)-1.1 (a)7.5 (p)-3.3 (illa)-3.4 (r)-8.9 (y)5.8 ( [)-9.6 (T)-13.6 (h)-3.3 (y)5.8 (r)-8.9 (o)-3.4 (id)-3.3 (])-9.6 ( )]TJ -0.002 Tc -0.004 Tw -8.543 -1.37 Td [(C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a\))4.9 (.)-6.6 ( T)-10.6 (he)10.5 ( )-10.6 (N)2.6 (C)2.6 (C)2.6 (N)2.7 ( P)2 (anel)2.6 ( )-10.6 (had )-10.6 (a m)-5.9 (aj)-8.3 (o)10.6 (r)-6 ( di)2.6 (s)-2 (agr)5 (eem)-6 (ent)4.3 ( )-10.6 (about)4.2 ( )]TJ 0.002 Tw 0 -1.38 Td [(r)-6 (ec)-2 (om)5 (m)]TJ 0.007 Tw 3.609 0 Td [(endi)2.6 (n)10.5 (g)-11.2 ( )11.2 (\()-5.9 (c)-2 (at)-6.6 (e)10.6 (g)-11.3 (o)10.6 (r)-6 (y)8.9 ( 3\))4.9 ( pos)-2.1 (t)]TJ 0 Tc 0 Tw 10.739 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(t)4.3 (r)-6 (eat)4.3 (m)-6 (en)10.5 (t)-6.6 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 616.68 218.4 Tm (131)Tj -0.005 Tc 0.01 Tw 11.04 -0 0 11.04 628.2 214.44 Tm [(I)-9.6 ( im)1.9 (a)-3.4 (g)-14.2 (in)7.5 (g)-14.2 ( in)-3.4 ( )11.3 (t)-9.6 (h)-3.4 (is)-5 ( s)-5 (e)7.5 (t)1.3 (t)-9.7 (in)-3.4 (g)-3.4 (,)-9.6 ( )]TJ -0.002 Tc 0.007 Tw -20.217 -1.37 Td [(bec)-2 (aus)-2 (e s)-2 (o)10.5 (m)-6 (e do)10.6 ( not)4.2 ( )11.3 (f)-17.5 (e)10.5 (el)2.6 ( t)-6.6 (hat)4.3 ( t)-6.6 (he)10.5 (s)-2 (e pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( s)-2 (ho)10.5 (ul)2.7 (d hav)8.9 (e i)2.6 (m)-5.9 (ag)-11.2 (i)2.6 (n)10.6 (g)-11.3 (.)4.3 ( N)2.6 (o )]TJ 0 -1.38 Td [(s)-2 (t)-6.6 (udy)8.9 ( has)-2 ( s)-2 (how)13.5 (n a dec)8.8 (r)-5.9 (e)10.5 (as)-2.1 (e i)2.6 (n )11.2 (m)-5.9 (or)-5.9 (bi)2.6 (di)2.6 (t)-6.6 (y)8.9 ( or)4.9 ( m)-5.9 (o)10.5 (r)-6 (t)-6.6 (a)10.6 (l)2.6 (i)2.6 (t)-6.6 (y)8.8 ( i)2.6 (n pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( )11.3 (t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (ed )]TJ -0.005 Tc 0.005 Tw 0 -1.37 Td [(wit)-9.6 (h)-3.4 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 427.68 172.92 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 439.2 168.96 Tm [(I)-6.6 ( on t)-6.6 (he)10.6 ( bas)-2 (i)2.6 (s)-2 ( o)10.5 (f)-6.6 ( i)13.5 (nc)-2 (r)-5.9 (eas)-2 (ed )11.2 (Tg )11.3 (m)-6 (eas)-2 (ur)-6 (e)10.5 (m)-5.9 (e)10.5 (n)]TJ [(t)-6.7 (s)-2 ( )0.5 (al)2.6 (one.)4.2 ( )11.3 (I)-6.6 (n a)10.6 ( l)2.6 (ong)]TJ 0 Tc 0 Tw (-)Tj -0.013 Tc 0.013 Tw 27.38 0 Td [(t)-17.6 (er)-16.9 (m)-6.1 ( )]TJ -0.005 Tc 0.005 Tw -30.478 -1.38 Td [(f)-9.6 (o)-3.4 (llo)-3.3 (w)]TJ 0 Tc 0 Tw 2.533 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up s)-2 (t)-6.6 (udy)8.9 (,)-6.6 ( no s)-2 (u)10.5 (r)-6 (v)8.9 (i)2.6 (v)8.9 (al)2.6 ( adv)8.8 (ant)-6.6 (ag)-11.2 (e w)13.5 (as)-2 ( as)-2 (s)-2 (o)10.5 (c)-2 (i)2.6 (at)-6.6 (ed w)13.5 (i)2.6 (t)-6.6 (h em)-6 (pi)2.7 (r)-6 (i)2.6 (c)8.9 ( )]TJ -0.005 Tc 0.005 Tw -2.87 -1.37 Td [(h)-3.3 (ig)-14.3 (h)]TJ 0 Tc 0 Tw 1.891 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(dos)-2 (e)10.5 ( R)2.6 (A)2 (I)4.2 ( i)2.7 (n pat)-6.6 (i)2.6 (en)10.5 (t)4.3 (s)-2 ( w)13.4 (i)2.6 (t)-6.6 (h neg)-11.2 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e i)2.6 (m)-5.9 (ag)-11.2 (i)2.6 (n)10.5 (g.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 639.84 142.56 Tm (388)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 651.36 138.6 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(Fur)-6 (t)-6.6 (her)4.9 (,)-6.6 ( po)10.6 (t)-6.6 (ent)-6.6 (i)2.6 (al)2.7 ( )]TJ 0.002 Tw -22.598 -1.38 Td [(l)2.6 (ong)]TJ 0 Tc 0 Tw 1.891 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(t)-6.6 (er)5 (m)-6 ( s)-2 (i)2.6 (de)10.5 ( e)10.5 (f)-6.6 (f)-6.6 (ec)-2 (t)4.3 (s)-2 ( )11.3 (\()-6 (i)2.6 (e,)-6.6 ( )]TJ [(x)8.8 (er)-6 (os)-2 (t)-6.6 (o)10.5 (m)-6 (i)2.7 (a,)4.3 ( nas)-2 (ol)2.6 (ac)-2 (r)-6 (i)13.5 (m)4.9 (al)2.6 ( duc)-2 (t)-6.6 ( )11.3 (s)-2 (t)-6.6 (enos)-2 (i)2.6 (s)8.9 (,)-6.6 ( bone)10.6 ( )]TJ -2.217 -1.37 Td [(m)-6 (ar)4.9 (r)-5.9 (ow)13.5 ( and )11.3 (g)-11.2 (onadal)2.6 ( c)-2 (o)10.5 (m)-6 (pr)-6 (o)10.6 (m)-6 (i)2.6 (s)-2 (e,)4.2 ( t)-6.6 (he)10.5 ( r)-6 (i)2.6 (s)8.9 (k)-2 ( o)10.5 (f)-6.6 ( he)10.5 (m)-6 (at)-6.6 (ol)2.6 (o)10.6 (g)-11.2 (i)2.6 (c)-2 ( and)10.5 ( ot)-6.6 (he)10.5 (r)-5.9 ( )]TJ -0.004 Tw 0 -1.38 Td [(m)-6 (al)2.6 (i)2.6 (g)-11.2 (nanc)-2 (i)2.6 (es)-2 (\))4.9 ( m)-5.9 (ay)8.9 ( )-10.6 (n)]TJ 0.007 Tw [(eg)-11.2 (a)10.5 (t)4.2 (e any)8.9 ( bene)10.5 (f)-17.4 (i)2.6 (t)4.2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 593.4 96.96 Tm [(389,)-1.8 (3)-17 (90)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 618.48 93 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 (c)-2 (t)-6.7 (i)2.7 (v)-2 (e s)-2 (ur)-6 (v)8.9 (ei)2.7 (l)2.6 (l)2.6 (anc)-2 (e m)-5.9 (ay)8.9 ( be )]TJ -19.62 -1.37 Td [(c)-2 (ons)-2 (i)2.6 (der)-5.9 (ed )11.3 (f)-6.7 (or)4.9 ( pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h l)2.6 (ow)]TJ 0 Tc 0 Tw 13.891 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(v)8.9 (o)-11.2 (l)2.6 (um)-5.9 (e di)2.6 (s)-2 (eas)-2 (e )11.3 (t)4.3 (hat)-6.6 ( i)2.6 (s)-2 ( )11.2 (s)-2 (t)-6.6 (abl)2.6 (e and)10.5 ( di)2.6 (s)-2 (t)-6.6 (an)10.6 (t)-6.7 ( )]TJ 0.004 Tc 0.001 Tw -14.228 -1.38 Td [(f)-0.6 (ro)16.5 (m c)14.9 (ri)8.6 (t)-0.6 (i)8.6 (c)4 (a)5.7 (l)8.6 ( s)14.8 (t)-0.6 (ru)5.6 (c)14.9 (t)-0.6 (u)5.6 (re)5.7 (s)14.9 (.)10.2 ( )]TJ 0 Tc 0 Tw 10.293 0 Td ( )Tj EMC ET endstream endobj 815 0 obj 26614 endobj %% Contents for page 88 %% Original object ID: 177 0 816 0 obj << /Length 817 0 R >> stream Q q BT /Xi86 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 817 0 obj 245 endobj %% Original object ID: 11421 0 818 0 obj [ 2653 0 R 2654 0 R ] endobj %% Contents for page 89 %% Original object ID: 178 0 819 0 obj << /Length 820 0 R >> stream q endstream endobj 820 0 obj 2 endobj %% Contents for page 89 %% Original object ID: 11422 0 821 0 obj << /Length 822 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td 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(s)-2 ( p)10.5 (r)-5.9 (ev)8.9 (ent)-6.6 ( s)8.9 (k)-12.9 (el)2.7 (e)10.5 (t)-6.6 (al)]TJ 0 Tc 0 Tw 10.25 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(r)4.9 (el)2.6 (at)-6.6 (ed ev)8.8 (ent)-6.6 (s)]TJ 0 Tc 0 Tw 6.261 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 212.64 347.04 Tm (395)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 1.983 0 Td [(39)-17 (7)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 238.08 343.08 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(E)2 (m)-6 (bol)2.6 (i)-8.2 (z)8.8 (at)-6.6 (i)2.6 (on \()-6 (or)4.9 ( ot)-6.6 (he)10.5 (r)-5.9 ( )]TJ -19.717 -1.37 Td [(i)2.6 (nt)-6.6 (er)-5.9 (v)8.8 (ent)-6.6 (i)2.6 (onal)2.6 ( pr)-5.9 (o)]TJ [(c)-2 (edur)-5.9 (e)10.5 (s)-2 (\))-6 ( o)10.6 (f)-6.7 ( )11.3 (m)-6 (et)-6.6 (a)10.5 (s)-2 (t)-6.6 (as)-2 (es)8.9 ( c)-2 (an)10.6 ( al)2.6 (s)8.9 (o be c)-1.9 (ons)-2 (i)2.7 (de)10.5 (r)-5.9 (ed ei)2.6 (t)-6.6 (he)10.5 (r)-5.9 ( )]TJ -0.004 Tw 0 -1.38 Td [(pr)-6 (i)2.6 (or)-6 ( t)-6.6 (o r)-6 (es)-2 (ec)8.9 (t)-6.6 (i)2.6 (on )-10.6 (or)4.9 ( )-10.6 (as)-2 ( a)10.5 (n 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(e)-3.4 (s)-5 ( )11.3 (f)-20.5 (o)7.5 (r)-8.9 ( Ce)-3.3 (n)7.5 (t)-9.6 (r)-9 (a)-3.3 (l Ne)7.5 (r)-9 (v)5.9 (o)-3.4 (u)-3.3 (s)-5 ( )]TJ ET 189.36 269.4 185.16 0.841 re f BT -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 256.2 Tm [(S)2 (y)8.8 (s)-2 (t)-6.6 (em)-6 ( C)2.6 (anc)-2 (er)4.9 (s)]TJ ET EMC /Span <>BDC BT /CS1 cs 0 scn -0.007 Tc 11.04 -0 0 11.04 104.28 256.2 Tm (\).)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 111 260.16 Tm [(311,)-1.8 (3)-17 (12)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 136.08 256.2 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(F)-10.6 (or)-6 ( )11.3 (m)-5.9 (ul)2.6 (t)-6.6 (i)2.6 (pl)2.6 (e C)2.6 (N)2.6 (S)2 ( l)2.6 (es)-2 (i)2.6 (ons)-2 (,)-6.6 ( )11.2 (s)-2 (ur)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( r)-6 (es)-2 (ec)8.9 (t)-6.6 (i)2.6 (on and)10.5 (/)-6.6 (or)4.9 ( )]TJ ET /CS0 cs 0 0.357 0.6 scn 23.52 254.16 80.761 0.84 re f BT /CS1 cs 0 scn 11.04 -0 0 11.04 23.52 241.08 Tm [(E)2 (B)1.9 (R)2.6 (T)-10.5 ( c)-2 (an)10.5 ( be c)-2 (o)10.6 (ns)-2 (i)2.6 (der)-5.9 (ed)10.5 ( \()-5.9 (s)-2 (ee)10.6 ( )]TJ /TT2 1 Tf -0.004 Tw [(Tr)-6 (ea)10.5 (t)-6.6 (m)-6 (en)10.5 (t)-6.6 ( of)4.3 ( )-10.6 (M)4.9 (et)-6.6 (a)10.5 (s)-2 (t)-6.6 (a)]TJ -0.005 Tc 0.01 Tw [(t)-9.6 (ic)5.9 ( Dis)-5 (e)-3.3 (a)-3.4 (s)-5 (e)]TJ /TT0 1 Tf 0 Tc 0 Tw 27.913 0 Td ( )Tj /TT2 1 Tf -0.006 Tc 0.006 Tw 0.283 0 Td [(N)-1.4 (o)-4.3 (t )]TJ -0.002 Tc 0.007 Tw -28.196 -1.38 Td [(A)2 (m)-6 (enabl)2.6 (e t)-6.6 (o)10.5 ( R)2.6 (A)1.9 (I)4.3 ( Ther)-5.9 (ap)10.6 (y)]TJ /TT0 1 Tf 0 Tc 0 Tw 11.467 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (n t)-6.6 (he)10.5 ( N)2.6 (C)2.7 (C)2.6 (N)2.6 ( G)-6.5 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (o)10.6 (r)-6 ( P)2 (api)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( [)4.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d])-6.6 ( )]TJ 0.002 Tw -11.75 -1.37 Td [(C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a\))4.9 (.)-6.6 ( )]TJ 0 Tc 0 Tw 5.707 0 Td ( )Tj ET EMC BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 184.56 Tm [(For)-6 ( c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.7 (l)2.6 (y)8.8 ( pr)-6 (og)-11.2 (r)-6 (es)8.8 (s)-2 (i)2.6 (v)8.9 (e)-11.2 ( or)4.9 ( s)-2 (y)8.9 (m)-5.9 (pt)-6.6 (o)10.5 (m)-5.9 (at)-6.6 (i)2.6 (c)8.9 ( di)2.6 (s)-2 (eas)-2 (e,)]TJ 0 Tc 0 Tw 21.935 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(r)-6 (ec)-2 (o)10.5 (m)-5.9 (m)-6 (en)10.5 (ded )]TJ 0.007 Tw -22.217 -1.38 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( op)10.5 (t)-6.6 (i)2.6 (ons)-2 ( )11.3 (t)-6.6 (hat)4.2 ( c)-2 (o)10.6 (ul)2.6 (d be c)-2 (ons)-2 (i)2.6 (der)-6 (ed)10.5 ( i)2.6 (nc)-2 (l)2.6 (ude:)-6.6 ( 1)10.5 (\))-5.9 ( l)2.6 (env)8.9 (at)-6.6 (i)2.6 (ni)2.6 (b )]TJ -0.004 Tw 0 -1.37 Td [(\()-6 (pr)-6 (e)10.6 (f)-6.6 (er)-5.9 (r)-6 (ed)10.6 (\))-6 ( or)5 ( )-10.7 (s)-1.9 (or)-6 (a)10.6 (f)-6.6 (eni)2.6 (b;)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 139.8 158.16 Tm [(328,)-19.1 (333)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 164.88 154.2 Tm ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(2)-3.3 (\))-9 ( c)-5 (lin)-3.4 (ic)-5 (a)-3.3 (l t)-9.7 (r)-8.9 (ia)-3.4 (ls)-5 (;)-9.6 ( 3)7.5 (\))-9 ( )]TJ -0.002 Tc -0.004 Tw [(o)10.6 (t)-6.7 (her)4.9 ( )-10.7 (s)-1.9 (m)-6 (al)2.6 (l)2.6 ( m)-5.9 (ol)2.7 (ec)-2 (ul)2.7 (e )]TJ 0.007 Tw -13.087 -1.38 Td [(k)-12.9 (i)2.6 (nas)-1.9 (e)10.5 ( i)2.6 (nhi)2.6 (bi)2.7 (t)-6.6 (or)-6 (s)-2 ( i)13.5 (f)-6.6 ( a )11.2 (c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( t)-6.6 (r)-6 (i)2.6 (al)2.6 ( i)2.6 (s)-2 ( n)10.5 (ot)4.2 ( av)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e;)-6.6 ( or)-5.9 ( 4)10.5 (\))-6 ( )11.3 (r)-5.9 (es)-2 (ec)-1.9 (t)-6.7 (i)2.7 (on)10.5 ( o)10.6 (f)-6.7 ( di)2.6 (s)-2 (t)-6.6 (an)10.6 (t)-6.6 ( )]TJ 0 -1.37 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 ( and/)-6.6 (o)10.5 (r)-5.9 ( E)2 (B)1.9 (R)13.5 (T or)4.9 ( I)-6.6 (M)15.8 (R)2.6 (T)-10.5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 192.36 127.8 Tm [(399,)-1.8 (40)-17 (0)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 217.44 123.84 Tm ( )Tj 0.009 Tc -0.009 Tw 0.283 0 Td (Th)Tj -0.002 Tc -0.004 Tw 1.174 0 Td [(e r)-5.9 (ec)8.9 (om)-5.9 (m)-6 (enda)10.5 (t)-6.6 (i)2.6 (ons)-2 ( f)-6.6 (or)5 ( )]TJ 0.007 Tw -19.022 -1.38 Td [(l)2.6 (env)8.9 (at)-6.6 (i)2.6 (ni)2.6 (b \()-6 (pr)-5.9 (e)10.5 (f)-17.5 (er)4.9 (r)-5.9 (ed\))4.9 ( or)4.9 ( )11.3 (s)-2 (or)-6 (a)10.5 (f)-17.5 (eni)2.6 (b a)10.5 (r)-5.9 (e ba)10.5 (s)-2 (ed on)10.5 ( p)10.5 (has)-2 (e 3 )11.3 (r)-6 (andom)-5.9 (i)2.6 (z)8.9 (ed )]TJ -0.005 Tc 0.005 Tw 0 -1.37 Td [(t)-9.6 (r)-9 (ia)-3.3 (ls)-5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 49.92 97.44 Tm [(328,)-1.8 (33)-17 (3)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 75 93.48 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (he N)2.7 (C)2.6 (C)2.6 (N)2.6 ( P)12.8 (anel)2.6 ( )11.2 (f)-17.4 (eel)2.6 (s)-2 ( )11.3 (t)-6.7 (hat)4.3 ( l)2.6 (env)8.9 (a)]TJ [(t)-6.6 (i)2.7 (ni)2.6 (b i)2.6 (s)-2 ( t)-6.7 (he p)10.5 (r)-6 (e)10.5 (f)-17.4 (e)10.5 (r)-6 (r)-5.9 (ed)10.6 ( a)10.6 (g)-11.2 (en)10.5 (t)-6.6 ( i)2.6 (n )]TJ -4.946 -1.38 Td [(t)-6.6 (hi)2.6 (s)-2 ( s)-2 (e)10.5 (t)-6.6 (t)-6.6 (i)2.6 (n)10.5 (g)-11.2 ( bas)8.9 (ed on)10.5 ( a )11.3 (r)4.9 (es)-2 (pons)-2 (e r)-5.9 (a)10.5 (t)-6.6 (e )11.3 (o)10.5 (f)-6.6 ( 65%)6.6 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( l)13.5 (env)8.9 (at)-6.6 (i)2.7 (ni)2.6 (b )-10.5 (w)13.5 (hen )]TJ 0 -1.37 Td [(c)-2 (om)-6 (par)-5.9 (ed)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h 12%)-4.3 ( )11.2 (f)-6.6 (or)4.9 ( s)8.9 (or)-5.9 (a)10.5 (f)-17.5 (eni)2.6 (b,)4.2 ( al)2.6 (t)-6.6 (hou)10.5 (g)-11.2 (h)10.5 ( t)-6.6 (hes)-2 (e)10.5 ( )11.3 (ag)-11.2 (en)10.5 (t)-6.6 (s)-2 ( hav)8.9 (e no)10.5 (t)-6.6 ( been)10.5 ( )]TJ 0 -1.38 Td [(di)2.6 (r)-6 (ec)-2 (t)-6.6 (l)2.6 (y)8.8 ( c)-2 (om)-6 (par)-5.9 (e)10.5 (d.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 113.52 51.84 Tm [(326,)-1.8 (32)-17 (8,)-1.9 (3)-17 (33)]TJ /TT1 1 Tf 0 Tc 0 Tw 11.04 -0 0 11.04 152.16 47.88 Tm ( )Tj /TT0 1 Tf -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (he dec)-1.9 (i)2.6 (s)-2.1 (i)2.7 (on )11.2 (t)-6.6 (o u)10.5 (s)-2 (e l)2.6 (e)10.5 (nv)8.9 (at)-6.6 (i)2.6 (ni)2.6 (b or)-5.9 ( s)-2 (or)-5.9 (a)10.5 (f)-6.6 (eni)2.6 (b )]TJ 22.62 42.217 Td [(s)-2 (houl)2.6 (d be i)2.6 (ndi)2.7 (v)8.8 (i)2.6 (dual)-8.3 (i)2.6 (z)8.9 (ed )-10.4 (f)-6.7 (or)4.9 ( eac)-2 (h pa)10.5 (t)-6.6 (i)2.6 (ent)4.3 ( bas)-2 (ed o)10.5 (n l)2.6 (i)2.6 (k)-12.9 (el)2.6 (i)2.6 (hood o)10.5 (f)-6.6 ( r)-5.9 (e)10.5 (s)-2 (pons)-2 (e )]TJ 0 -1.38 Td [(and c)-2 (om)-5.9 (o)10.5 (r)-6 (bi)2.6 (di)2.7 (t)-6.7 (i)2.7 (es)-2 (.)4.3 ( )]TJ 8.359 0 Td [(T)-10.6 (he e)10.6 (f)-6.7 (f)-6.6 (i)2.7 (c)-2.1 (ac)-2 (y)8.9 ( o)10.5 (f)-6.6 ( l)2.6 (env)8.9 (at)-6.6 (i)2.6 (ni)2.6 (b or)-6 ( s)-2 (o)10.6 (r)-6 (a)10.5 (f)-17.5 (eni)2.6 (b )11.3 (f)]TJ 17.076 0 Td [(or)4.9 ( pat)-6.6 (i)2.6 (en)10.6 (t)-6.7 (s)-1.9 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ -25.435 -1.37 Td [(br)-6 (ai)2.7 (n m)-5.9 (e)10.5 (t)-6.6 (as)8.9 (t)-6.6 (as)-1.9 (es)-2 ( ha)10.5 (s)-2 ( no)10.6 (t)-6.7 ( been)10.5 ( es)-2 (t)-6.6 (abl)2.6 (i)2.6 (s)-2 (hed;)4.3 ( t)-6.6 (he)10.6 (r)-6 (e)10.5 (f)-6.6 (or)-6 (e)10.6 (,)-6.7 ( c)-2 (ons)-2 (ul)13.5 (t)-6.6 (at)-6.6 (i)2.6 (on w)13.5 (i)2.6 (t)-6.6 (h )]TJ 0 -1.38 Td [(neur)-6 (os)-2 (ur)4.9 (g)-11.2 (eons)8.8 ( and)10.5 ( r)-6 (adi)2.6 (a)10.6 (t)-6.7 (i)2.7 (on onc)-1.9 (ol)2.6 (o)10.6 (g)-11.3 (i)2.6 (s)-2 (t)-6.6 (s)8.9 ( i)2.6 (s)-2 ( r)-5.9 (e)10.5 (c)-2 (om)4.9 (m)-5.9 (ended.)4.2 ( K)2 (i)2.6 (nas)-2 (e )]TJ 0.002 Tw 0 -1.37 Td [(i)2.6 (nhi)2.6 (bi)2.6 (t)-6.6 (or)-5.9 (s)]TJ 0 Tc 0 Tw 3.989 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(hav)8.9 (e )]TJ 0.007 Tw 2.435 0 Td [(been us)-2 (e)10.5 (d as)-2 ( s)-2 (e)10.5 (c)-2 (ond)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 9.815 0 Td [(l)2.6 (i)2.6 (ne )-10.6 (t)-6.6 (h)10.5 (er)-6 (apy)8.9 ( f)-17.5 (o)10.5 (r)-5.9 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )-10.6 (c)-2 (anc)-2 (er)4.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 735.36 457.2 Tm [(329,)-1.8 (3)-17 (30)]TJ /TT1 1 Tf 0 Tc 0 Tw 11.04 -0 0 11.04 760.56 453.24 Tm ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw -32.207 -2.38 Td [(Lenv)8.8 (at)-6.6 (i)2.6 (ni)2.7 (b )-10.5 (w)13.5 (as)-2 ( c)-2 (om)-5.9 (par)-6 (e)10.5 (d )]TJ [(w)13.5 (i)2.6 (t)-6.6 (h pl)2.6 (ac)-2 (ebo i)2.6 (n pat)-6.5 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(v)8.8 (i)2.6 (ng)-11.2 ( l)2.6 (env)8.9 (at)-6.6 (i)2.6 (ni)2.6 (b had a )]TJ -0.013 Tc 0.013 Tw [(pr)-16.9 (og)-22.2 (r)-17 (e)-11.3 (s)-13 (s)-13 (i)-8.4 (o)-11.4 (n)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 17.054 0 Td [(f)-6.6 (r)-6 (ee )]TJ -0.011 Tc 0.016 Tw -29.63 -1.37 Td [(s)-11 (u)-9.3 (r)-15 (vi)-6.4 (va)-20.2 (l)-6.4 ( \()]TJ -0.004 Tc 0.004 Tw 3.989 0 Td [(PF)-1.7 (S)]TJ 0 Tc 0 Tw (\))Tj 2.272 0 Td ( )Tj -0.013 Tc 0.018 Tw 0.283 0 Td [(of)-17.6 ( 1)-11.3 (8.)]TJ 0 Tc 0 Tw 2.489 0 Td (3)Tj 0.554 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(m)4.9 (ont)-6.6 (hs)-2 ( c)-2 (o)10.5 (m)-6 (pa)10.5 (r)-6 (ed w)13.4 (i)2.6 (t)-6.6 (h )]TJ [(3.)-6.6 (6)10.6 ( m)-5.9 (on)10.6 (t)-6.6 (hs)-2 ( )]TJ -0.004 Tw 15.511 0 Td [(f)-6.6 (or)5 ( t)-6.6 (hos)-2 (e )]TJ 0.007 Tw -25.37 -1.38 Td [(r)-6 (ec)-2 (ei)2.7 (v)8.8 (i)2.7 (ng)-11.2 ( pl)2.6 (ac)-2 (ebo)]TJ 0 Tc 0 Tw ( )Tj 8.033 0 Td (\()Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(haz)8.9 (ar)-5.9 (d r)-5.9 (a)10.5 (t)-6.6 (i)2.6 (o [)-6.6 (H)2.6 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822 0 obj 28948 endobj %% Contents for page 89 %% Original object ID: 179 0 823 0 obj << /Length 824 0 R >> stream Q q BT /Xi87 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 824 0 obj 245 endobj %% Contents for page 90 %% Original object ID: 180 0 825 0 obj << /Length 826 0 R >> stream q endstream endobj 826 0 obj 2 endobj %% Contents for page 90 %% Original object ID: 11425 0 827 0 obj << /Length 828 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (27)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(di)2.6 (s)-2 (eas)-2 (e\))-5.9 (,)4.2 ( )-10.6 (l)2.6 (ar)-6 (ot)4.2 (r)-5.9 (ec)-1.9 (t)-6.7 (i)2.7 (ni)2.6 (b \()4.9 (f)-17.4 (o)10.5 (r)-6 ( )]TJ /TT2 1 Tf -0.005 Tc 0.005 Tw 11.533 0 Td [(NT)-2.7 (RK)]TJ /TT0 1 Tf 0 Tc 0 Tw 2.707 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.272 0 Td [(g)-11.2 (ene)10.5 ( f)-17.5 (us)-1.9 (i)2.6 (on )]TJ 0.007 Tw 5.446 0 Td [(p)10.5 (os)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (e di)2.6 (s)-2 (eas)-2 (e\))-5.9 (,)-6.6 ( ax)8.9 (i)2.6 (t)-6.6 (i)2.6 (ni)2.6 (b,)-6.6 ( )]TJ -19.957 -1.38 Td [(ev)8.8 (er)-6 (ol)2.6 (i)2.6 (m)-6 (us)-2 (,)-6.6 ( paz)8.9 (opani)2.6 (b,)-6.6 ( s)8.9 (uni)2.6 (t)-6.6 (i)2.6 (ni)2.6 (b,)-6.6 ( v)8.9 (andet)-6.6 (ani)2.6 (b,)]TJ 0 Tc 0 Tw 19.891 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(o)10.5 (r)-5.9 ( c)8.8 (aboz)8.9 (ant)-6.6 (i)2.6 (ni)2.6 (b)]TJ 0 Tc 0 Tw <97>Tj -0.002 Tc 0.002 Tw [(al)2.6 (t)-6.6 (houg)-11.2 (h )]TJ 0.007 Tw -20.174 -1.37 Td [(s)-2 (om)-6 (e o)10.6 (f)-6.6 ( )11.2 (t)-6.6 (hes)-2 (e)10.6 ( hav)8.8 (e not)4.2 ( )11.3 (been appr)-6 (ov)8.8 (ed by)8.9 ( t)-6.6 (he)10.5 ( F)11.2 (D)2.6 (A)2 ( )11.2 (f)-17.4 (or)4.9 ( di)13.5 (f)-6.7 (f)-17.4 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (a)10.6 (t)-6.6 (ed )]TJ 0 -1.38 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 ( \()-5.9 (s)-2 (ee)10.6 ( )]TJ /TT2 1 Tf [(P)1.9 (r)-5.9 (i)2.6 (nc)8.9 (i)2.6 (pl)2.6 (es)-2 ( of)-6.6 ( K)1.9 (i)2.6 (nas)-2 (e )11.3 (I)-6.7 (nhi)2.6 (bi)2.6 (t)-6.6 (or)4.9 ( )11.3 (Ther)-6 (apy)-2 ( i)2.6 (n A)1.9 (dv)-2 (an)10.6 (c)-2 (ed )]TJ 0.002 Tw 0 -1.37 Td [(Thy)-2 (r)-6 (oi)2.6 (d )]TJ -0.005 Tc 0.005 Tw 3.609 0 Td [(Ca)-3.4 (r)-8.9 (c)-5 (in)-3.4 (o)7.6 (m)-9 (a)]TJ /TT0 1 Tf 0 Tc 0 Tw 4.815 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (n )11.2 (t)-6.6 (h)10.5 (e N)2.6 (C)2.6 (C)2.6 (N)2.6 ( G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )11.2 (Thy)8.9 (r)-6 (oi)2.6 (d C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a\))5 (.)-6.7 ( )0.5 (N)2.6 (ot)-6.6 (e)10.5 ( )]TJ -8.707 -1.38 Td [(t)-6.6 (hat)4.3 ( )11.2 (k)-12.8 (i)2.6 (nas)-2 (e i)2.6 (nhi)2.6 (bi)2.6 (t)-6.6 (or)4.9 ( t)-6.6 (he)10.5 (r)4.9 (apy)8.8 ( m)-5.9 (ay)8.9 ( not)-6.6 ( be)10.6 ( appr)-5.9 (op)10.5 (r)-5.9 (i)2.6 (at)-6.6 (e )11.3 (f)-6.7 (or)4.9 ( pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h s)-2 (t)-6.6 (abl)13.5 (e )]TJ 0 -1.37 Td [(or)-6 ( s)-2 (l)2.6 (ow)13.4 (l)-8.2 (y)8.8 ( pr)-6 (ogr)-5.9 (es)-1.9 (s)-2.1 (i)2.7 (v)8.8 (e i)2.6 (ndol)2.6 (ent)-6.7 ( di)2.6 (s)-2 (eas)-2 (e.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 212.04 426.84 Tm [(328,)-1.8 (33)-17 (3,)-1.9 (3)-17 (64,)-19.1 (40)-17 (2,)-19.1 (403)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 277.92 422.88 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 (c)-2 (t)-6.7 (i)2.7 (v)8.8 (e s)-2 (ur)-5.9 (v)8.8 (ei)-8.3 (l)2.7 (l)2.6 (anc)-2 (e i)2.6 (s)-2 ( )]TJ -23.326 -1.38 Td [(o)10.5 (f)-17.5 (t)-6.6 (en)10.5 ( appr)-6 (op)10.5 (r)-6 (i)2.6 (at)-6.6 (e )11.3 (f)-6.6 (or)4.9 ( as)-2 (y)8.9 (m)-6 (pt)-6.6 (o)10.5 (m)-6 (at)-6.6 (i)2.6 (c)8.9 ( pat)-6.6 (i)2.6 (ent)4.2 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h i)2.6 (ndol)2.7 (ent)-6.5 ( di)2.6 (s)-2 (eas)-2 (e and)10.5 ( no )]TJ 0 -1.37 Td [(br)-6 (ai)2.7 (n m)-5.9 (e)10.5 (t)-6.6 (as)8.9 (t)-6.6 (as)-2 (i)2.7 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 106.8 396.48 Tm [(329,)-1.8 (36)-17 (4)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 132 392.52 Tm ( )Tj EMC /H1 <>BDC /TT1 1 Tf 0.009 Tc 12.96 -0 0 12.96 23.52 364.92 Tm [(Follicular Th)-9.6 (y)18.7 (roid )-9.2 (Carcinoma )]TJ 0 Tc ( )Tj EMC /P 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(T)-10.5 (he di)2.7 (a)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)8.8 ( o)10.6 (f)-6.6 ( )11.2 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.38 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( r)-6 (e)10.6 (q)-11.3 (ui)2.6 (r)-6 (es)8.9 ( ev)8.9 (i)2.6 (denc)-2 (e o)10.5 (f)-6.6 ( i)2.6 (nv)8.9 (as)-2 (i)2.6 (on t)-6.6 (hr)-6 (ou)10.5 (g)-11.2 (h)10.5 ( t)-6.6 (he)10.6 ( c)-2.1 (aps)-2 (ul)2.6 (e o)10.5 (f)-6.6 ( )11.3 (t)-6.7 (he nodul)13.4 (e )]TJ 0 -1.37 Td [(or)-6 ( )11.3 (t)-6.6 (he p)10.5 (r)-6 (es)-2 (enc)-2 (e)10.5 ( o)10.5 (f)-6.6 ( v)8.9 (as)-2 (c)-2 (ul)2.6 (ar)-6 ( i)2.6 (nv)8.8 (as)-2 (i)2.6 (on.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 202.68 289.56 Tm [(45,)-19 (40)-16.9 (4)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 224.04 285.6 Tm ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(Un)-3.4 (lik)-15.9 (e)-3.4 ( )11.3 (P)-1.1 (T)-13.5 (C,)1.2 ( F)-2.7 (NA)-1 ( is)-5 ( n)-3.3 (o)7.5 (t)-9.6 ( s)-5 (p)7.6 (e)-3.4 (c)-5 (i)10.5 (f)-20.5 (ic)-5 ( )]TJ -0.001 Tw -18.446 -1.38 Td [(f)-9.6 (o)-3.4 (r)1.9 ( f)-20.5 (o)-3.4 (llic)-5 (u)-3.4 (la)-3.3 (r)-9 ( )]TJ -0.002 Tc 0.007 Tw 5.38 0 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (a)10.5 (r)-6 (c)-2 (i)13.5 (nom)-5.9 (a and)10.5 ( ac)-2 (c)-2 (oun)10.5 (t)-6.6 (s)-2 ( )11.3 (f)-6.6 (or)4.9 ( )0.5 (t)4.2 (he m)-5.9 (ai)2.6 (n di)13.5 (f)-6.6 (f)-6.6 (e)10.5 (r)-5.9 (enc)-2 (es)-2 ( i)2.6 (n)10.5 ( )]TJ -5.38 -1.37 Td [(m)-6 (ana)10.6 (g)-11.2 (em)-5.9 (en)10.5 (t)-6.6 ( o)10.6 (f)-6.7 ( )11.3 (t)-6.6 (he)10.6 ( 2 )11.3 (t)-6.6 (u)10.5 (m)-5.9 (or)4.9 ( t)-6.6 (y)8.9 (pes)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 191.16 259.2 Tm [(74,)-1.8 (81,)-19.2 (116)-17 (,)-1.8 (4)-17 (05)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 235.68 255.24 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (he )11.3 (FN)2.6 (A)2 ( c)-2 (y)8.9 (t)-6.7 (ol)2.6 (og)-11.3 (i)2.7 (c)-2 ( di)2.6 (a)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)-2 ( )]TJ -0.013 Tc -19.5 -1.38 Td [(of)-28.5 <2093>-17 ([)]TJ -0.002 Tc -0.004 Tw 1.728 0 Td [(s)-2 (us)-2 (pi)2.6 (c)-2 (i)2.6 (ous)8.9 ( f)-17.5 (o)10.5 (r)]TJ 0 Tc 0 Tw 6.087 0 Td (])Tj 0.272 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( neopl)2.6 (as)-2 (m)]TJ 8.261 0 Td [<94>-6 ( w)13.5 (i)2.6 (l)2.6 (l)2.6 ( pr)-6 (ov)8.9 (e t)-6.6 (o be a)10.5 ( beni)2.6 (g)-11.2 (n)10.5 ( )11.3 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( )]TJ -16.62 -1.37 Td [(adenom)-6 (a i)2.6 (n 80)10.5 (%)-4.3 ( o)10.5 (f)-6.6 ( )11.3 (c)-2 (as)-2 (e)10.6 (s)-2.1 (.)-6.6 ( H)2.6 (ow)13.5 (ev)8.9 (er)-5.9 (,)-6.6 ( 20%)6.6 ( o)10.5 (f)-6.6 ( pat)-6.6 (i)2.6 (e)10.5 (nt)]TJ -0.005 Tc -0.001 Tw 22.88 0 Td [(s)-5 ( )-10.6 (w)10.4 (it)-9.6 (h)-3.3 ( f)-20.4 (o)-3.4 (llic)-5 (u)-3.4 (la)-3.3 (r)-9 ( )]TJ -0.002 Tc 0.007 Tw -22.88 -1.38 Td [(neopl)2.6 (as)-2 (m)-6 (s)-2 ( on)10.5 ( FN)2.6 (A)2 ( ar)-5.9 (e)10.5 ( u)10.5 (l)2.6 (t)-6.6 (i)2.6 (m)-6 (at)-6.6 (el)2.6 (y)8.8 ( di)2.6 (ag)-11.3 (nos)-2 (ed)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h )0.5 (f)-6.7 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.37 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( w)13.5 (hen t)-6.6 (he )11.3 (f)-17.5 (i)2.6 (nal)13.5 ( pat)-6.6 (hol)2.6 (o)10.5 (g)-11.2 (y)8.9 ( i)2.6 (s)-2 ( as)-2 (s)-2 (es)-2 (s)8.9 (ed.)4.2 ( )11.3 (M)15.8 (o)-11.2 (l)2.6 (ec)-2 (ul)2.6 (ar)-6 ( di)2.7 (ag)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)-2 ( )]TJ 0 -1.38 Td [(t)-6.6 (es)-2 (t)-6.6 (i)2.7 (n)10.5 (g)-11.2 ( )11.2 (m)-5.9 (ay)8.9 ( be u)10.5 (s)-2 (e)10.5 (f)-17.4 (ul)2.6 ( )11.3 (t)-6.6 (o )11.3 (det)-6.6 (er)4.9 (m)-6 (i)2.6 (ne t)-6.6 (he)10.5 ( s)8.9 (t)-6.7 (at)-6.6 (us)8.9 ( o)10.5 (f)-6.6 ( )11.3 (f)4.3 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( l)2.6 (es)-2 (i)2.6 (ons)-2 ( or)-5.9 ( l)2.6 (es)-2 (i)2.6 (ons)-2 ( )]TJ 0 -1.37 Td [(o)10.5 (f)-17.5 ( i)2.7 (ndet)-6.6 (e)10.5 (r)-5.9 (m)-6 (i)2.6 (na)10.5 (t)-6.6 (e s)-1.9 (i)13.4 (g)-11.2 (ni)13.4 (f)-17.4 (i)]TJ 9.978 0 Td [(c)-2 (a)10.5 (nc)-2 (e \()-5.9 (i)2.6 (nc)-2 (l)2.7 (udi)2.7 (ng )11.2 (f)-17.4 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( n)10.5 (eopl)2.6 (as)-1.9 (m)-6 (s)-2 (,)4.2 ( )0.5 (A)1.9 (U)2.6 (S)2 (,)-6.6 ( o)10.5 (r)-6 ( )]TJ -9.978 -1.38 Td [(FLU)2.6 (S)1.9 (\))-5.9 ( as)-2 ( )11.3 (m)-6 (o)10.5 (r)-5.9 (e o)10.6 (r)-6 ( l)2.6 (es)-2 (s)8.9 ( l)2.6 (i)2.7 (k)-12.9 (el)2.6 (y)8.8 ( t)-6.6 (o)10.5 ( be )11.3 (m)-5.9 (al)2.6 (i)2.6 (g)-11.2 (nan)10.5 (t)-6.6 ( bas)8.9 (ed on )11.3 (t)-6.6 (he )11.2 (g)-11.2 (ene)10.5 (t)-6.6 (i)2.7 (c)-2 ( p)10.5 (r)-6 (o)10.5 (f)-17.4 (i)2.6 (l)2.6 (e.)4.3 ( )]TJ 0 -1.37 Td [(Fur)-6 (t)-6.6 (he)10.6 (r)-6 ( di)2.6 (a)10.5 (g)-11.2 (nos)-2 (t)-6.6 (i)2.6 (c)8.9 ( and )11.3 (t)-6.6 (r)4.9 (eat)-6.6 (m)-6 (en)10.5 (t)-6.6 ( dec)-2 (i)2.6 (s)-2 (i)2.6 (ons)8.9 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (ho pr)-6 (es)-2 (en)10.5 (t)4.3 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ 0 -1.38 Td [(f)-6.6 (ol)2.7 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( neopl)2.7 (as)-2 (m)-6 (s)-1.9 ( a)10.6 (r)-6 (e)10.5 ( )11.3 (bas)-2 (ed on )11.3 (t)-6.6 (hei)2.6 (r)4.9 ( )11.3 (T)-10.6 (S)2 (H)2.6 ( l)2.6 (ev)8.9 (el)-8.3 (s)-2 ( \()-6 (s)-2 (ee)10.5 ( )]TJ /TT2 1 Tf 0.002 Tw [(N)2.6 (odul)]TJ 0.007 Tw 27.25 0 Td [(e E)2 (v)-2 (al)2.6 (uat)-6.6 (i)2.6 (on)]TJ /TT0 1 Tf 0 Tc 0 Tw 5.478 0 Td ( )Tj -0.002 Tc 0.007 Tw -32.728 -1.37 Td [(i)2.6 (n t)-6.6 (he N)2.6 (C)2.6 (C)2.6 (N)2.6 ( )11.2 (G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( f)-6.6 (or)4.9 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d C)2.6 (ar)-5.9 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (\))-6 (.)]TJ 0 Tc 0 Tw 21.326 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -21.326 -2.37 Td [(B)2 (ec)-2 (aus)-2 (e m)-6 (o)10.5 (s)-2 (t)4.3 ( pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( w)13.4 (i)2.7 (t)-6.7 (h )11.3 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( neopl)2.7 (as)-2 (m)4.9 (s)-2 ( o)10.6 (n FN)2.6 (A)2 ( ac)-2 (t)-6.6 (ual)2.6 (l)2.6 (y)8.9 ( hav)8.9 (e )]TJ 0 -1.38 Td [(beni)2.6 (g)-11.2 (n di)2.7 (s)-2 (eas)-2 (e)10.5 (,)-6.6 ( )11.3 (t)-6.6 (ot)-6.6 (al)13.4 ( t)-6.6 (hy)8.8 (r)4.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( i)2.6 (s)-2 ( )11.3 (r)-6 (ec)-2 (om)4.9 (m)-5.9 (end)10.5 (ed onl)2.6 (y)8.9 ( i)2.6 (f)-6.6 ( i)2.6 (nv)8.9 (as)-2 (i)-8.3 (v)8.9 (e )]TJ 0 -1.37 Td [(c)-2 (anc)-2 (er)-6 ( o)10.5 (r)-5.9 ( )11.2 (m)-5.9 (e)10.5 (t)-6.6 (as)-2 (t)-6.5 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( di)2.6 (s)-2 (e)10.5 (as)-2 (e i)2.6 (s)-2 ( appa)10.5 (r)-5.9 (ent)4.2 ( )0.5 (at)4.3 ( t)-6.6 (he)10.5 ( t)-6.6 (i)13.5 (m)-6 (e o)10.5 (f)-6.6 ( s)-2 (u)10.5 (r)]TJ -0.013 Tc 0.018 Tw 25.587 0 Td [(g)-22.2 (e)-11.4 (r)-16.9 (y)-2.2 ( or)-17 ( i)2.5 (f)-17.6 ( t)-17.6 (h)-11.4 (e )]TJ -0.002 Tc 0.007 Tw 8.967 42.304 Td [(pat)-6.6 (i)2.6 (ent)-6.6 ( op)10.6 (t)-6.6 (s)8.8 ( )11.3 (f)-17.5 (o)10.6 (r)-6 ( )11.3 (t)-6.7 (ot)-6.6 (al)2.7 ( )11.2 (t)-6.6 (hy)8.8 (r)5 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( t)-6.6 (o)10.5 ( av)8.8 (oi)2.6 (d a s)-2 (ec)8.9 (ond pr)-5.9 (oc)-2 (edu)10.5 (r)-5.9 (e )11.3 (\()-5.9 (i)2.6 (e,)-6.6 ( )]TJ 0 -1.38 Td [(c)-2 (om)-6 (pl)2.7 (et)-6.6 (i)2.6 (on )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)4.9 (y)8.8 (\))-5.9 ( i)2.6 (f)-6.6 ( c)-2 (anc)-2 (e)10.5 (r)-5.9 ( i)2.6 (s)8.8 ( )11.3 (f)-17.5 (ound)10.5 ( at)4.2 ( p)10.5 (at)-6.6 (hol)2.6 (og)-11.3 (i)2.6 (c)8.9 ( r)-5.9 (ev)8.9 (i)2.6 (ew)13.5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 722.88 502.68 Tm [(4)-17 (04,)-19.1 (40)-17 (6)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 748.2 498.72 Tm ( )Tj -0.002 Tc 0.007 Tw -31.087 -1.37 Td [(O)-6.6 (t)-6.6 (he)10.5 (r)-5.9 (w)13.5 (i)2.6 (s)-2 (e,)-6.6 ( l)2.7 (obec)-2 (t)-6.6 (om)-5.9 (y)8.9 ( pl)13.5 (us)-2 ( i)2.7 (s)-2 (t)-6.7 (h)10.6 (m)-6 (us)-2 (ec)8.9 (t)-6.6 (om)-5.9 (y)8.9 ( i)2.6 (s)-2 ( adv)8.8 (i)2.6 (s)-2 (ed )0.5 (as)-2 ( )11.3 (t)-6.6 (he)10.5 ( i)2.6 (ni)2.6 (t)-6.6 (i)2.6 (al)2.6 ( s)-2 (ur)4.9 (g)-11.2 (er)-6 (y)8.9 (.)4.3 ( )]TJ 0 -1.38 Td [(I)4.3 (f)-6.7 ( i)2.7 (nv)8.9 (as)-2 (i)-8.2 (v)8.8 (e f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-6 (a )11.3 (\()-6 (ex)8.8 (t)-6.6 (ens)-2 (i)2.6 (v)8.9 (e )0.5 (v)-2 (as)-2 (c)-2 (ul)2.6 (ar)-5.9 ( i)2.6 (nv)8.9 (as)-2 (i)2.6 (on\))-6 ( i)2.6 (s)-2 ( )]TJ 0 -1.37 Td [(f)-6.6 (ound on)10.6 ( t)-6.6 (he)10.5 ( )11.3 (f)-17.5 (i)2.6 (nal)2.6 ( )0.5 (hi)2.6 (s)-2 (t)-6.6 (ol)2.6 (o)10.5 (g)-11.2 (i)2.6 (c)-2 ( )11.2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (ons)8.9 ( a)10.5 (f)-6.6 (t)-6.6 (er)5 ( l)2.6 (obec)-2 (t)-6.6 (o)10.5 (m)-5.9 (y)8.9 ( pl)2.6 (us)-2 ( i)2.6 (s)-2 (t)-6.6 (h)10.5 (m)-6 (us)-2 (ec)8.8 (t)-6.6 (om)-6 (y)8.9 (,)-6.6 ( )]TJ 0 -1.38 Td [(pr)-6 (om)-5.9 (p)10.5 (t)-6.6 ( c)-2 (o)10.5 (m)-5.9 (pl)2.6 (et)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (o)]TJ [(i)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( i)2.6 (s)8.9 ( r)-5.9 (ec)-2 (o)10.6 (m)-6 (m)-5.9 (en)10.5 (ded \()-6 (s)-2 (ee)10.5 ( )]TJ /TT2 1 Tf 0.004 Tc -0.004 Tw [(P)8 (ri)8.6 (ma)16.5 (ry)14.9 ( )]TJ -0.002 Tc 0.002 Tw 0 -1.37 Td [(Tr)-6 (eat)4.3 (m)-5.9 (ent)]TJ /TT0 1 Tf 0 Tc 0 Tw 4.543 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (n t)-6.6 (he)10.5 ( N)2.6 (C)2.7 (C)2.6 (N)2.6 ( )11.2 (G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (or)4.9 ( Fol)2.6 (l)2.6 (i)2.7 (c)-2 (ul)2.6 (ar)-6 ( [)4.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d])-6.6 ( C)2.6 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.5 (\))-5.9 (.)4.2 ( )]TJ 0 Tc 0 Tw 26.402 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -31.228 -2.38 Td [(C)2.6 (om)-6 (pl)2.7 (et)-6.6 (i)2.6 (on t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (dec)-2 (t)-6.6 (o)10.5 (m)4.9 (y)8.9 ( i)2.6 (s)-2 ( al)2.6 (s)-2 (o r)-6 (ec)-2 (o)10.5 (m)-6 (m)-5.9 (ended)10.5 ( )11.3 (f)-6.6 (or)-5.9 ( )11.3 (t)-6.7 (um)-6 (o)10.6 (r)-6 (s)-2 ( )11.3 (t)-6.6 (hat)4.2 (,)4.3 ( on )11.3 (f)-17.5 (i)2.6 (nal)2.6 ( )]TJ 0 -1.37 Td [(hi)2.6 (s)-2 (t)-6.6 (ol)2.6 (og)-11.2 (i)2.6 (c)-2 ( )11.2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (ons)8.9 ( a)10.5 (f)-6.6 (t)-6.6 (er)4.9 ( l)2.6 (obec)-2 (t)-6.6 (om)-5.9 (y)8.9 ( pl)2.6 (us)-2 ( i)2.6 (s)8.9 (t)-6.7 (hm)-6 (u)10.6 (s)-2 (e)10.5 (c)-2 (t)-6.6 (om)-5.9 (y)8.9 (,)4.2 ( ar)-6 (e)10.5 ( i)2.6 (dent)-6.6 (i)13.5 (f)-17.5 (i)2.6 (ed as)8.8 ( )]TJ -0.005 Tc 0.005 Tw 0 -1.38 Td [(m)-9 (in)]TJ -0.002 Tc 0.007 Tw 1.609 0 Td [(i)2.6 (m)-5.9 (al)2.6 (l)2.6 (y)8.9 ( i)2.6 (n)-11.2 (v)8.9 (as)-2 (i)-8.2 (v)8.8 (e f)-17.5 (ol)2.7 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (no)10.6 (m)-6 (as)-2 (.)4.2 ( )]TJ -0.005 Tc 0.01 Tw [(M)1.9 (in)-3.3 (im)-9 (a)-3.3 (ll)-11.3 (y)5.9 ( in)-3.4 (v)5.9 (a)-3.4 (s)-5 (i)-11.3 (v)5.9 (e)]TJ 0 Tc 0 Tw 27.565 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(c)-2 (anc)-2 (er)-6 ( )]TJ 0.007 Tw -29.457 -1.37 Td [(i)2.6 (s)-2 ( c)-2 (har)-6 (ac)8.9 (t)-6.6 (er)-5.9 (i)2.6 (z)8.8 (ed )0.5 (as)-2 ( a)10.5 ( w)13.5 (el)-8.3 (l)]TJ 0 Tc 0 Tw 11.13 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(de)10.5 (f)-17.5 (i)2.6 (ned t)-6.7 (u)10.6 (m)-6 (o)10.6 (r)-6 ( w)13.5 (i)2.6 (t)-6.6 (h m)-5.9 (i)2.6 (c)-2 (r)4.9 (os)-2 (c)-2 (opi)2.6 (c)-2 ( c)-2 (aps)-2 (ul)2.6 (ar)4.9 ( and/)-6.7 (o)10.6 (r)-6 ( )]TJ -0.016 Tc 0.021 Tw -11.467 -1.38 Td [(f)-20.6 (e)-14.4 (w \()-20 (1)]TJ 0 Tc 0 Tw 2.717 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(4\))4.9 ( )11.2 (f)-17.4 (o)10.5 (c)-2 (i)2.6 ( o)10.5 (f)-6.6 ( v)8.9 (as)-2 (c)-2 (ul)2.6 (ar)-5.9 ( i)2.6 (nv)8.9 (as)-2 (i)2.6 (on and o)10.6 (f)-17.5 (t)-6.6 (en)10.6 ( r)-5.9 (e)10.5 (q)-11.2 (ui)13.5 (r)-5.9 (es)-2 ( ex)8.8 (am)-6 (i)2.7 (nat)-6.7 (i)2.7 (on o)10.5 (f)-6.6 ( a)10.5 (t)4.3 ( )]TJ -3.054 -1.37 Td [(l)2.6 (eas)-2 (t)-6.6 ( 10 hi)2.6 (s)8.8 (t)-6.6 (ol)2.6 (og)-11.2 (i)2.6 (c)8.9 ( s)-2 (ec)8.8 (t)-6.6 (i)2.6 (ons)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 539.04 324.72 Tm (407)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 550.56 320.76 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(M)4.9 (i)2.6 (ni)2.6 (m)-6 (al)2.6 (l)-8.3 (y)8.9 ( i)2.6 (n)-11.2 (v)8.9 (as)-2 (i)-8.2 (v)8.8 (e c)-2 (anc)-2 (er)-5.9 (s)8.9 (,)-6.7 ( )0.5 (as)8.9 ( w)13.5 (el)2.6 (l)2.6 ( as)-2 ( )]TJ -13.467 -1.38 Td [(N)2.6 (I)-6.6 (FT)-10.6 (P)12.9 ( t)-6.6 (u)10.5 (m)-6 (or)4.9 (s)-2 (,)4.3 ( m)-6 (ay)8.8 ( al)2.6 (s)-2 (o )11.3 (be s)-2 (i)2.6 (m)-5.9 (pl)2.6 (y)8.9 ( )11.3 (f)-17.5 (ol)2.6 (l)2.7 (ow)13.5 (ed c)-2 (ar)-5.9 (e)10.5 (f)-6.6 (ul)2.6 (l)-8.3 (y)8.9 (,)-6.6 ( bec)-2 (aus)-2 (e )11.3 (m)-6 (i)2.6 (ni)2.6 (m)-5.9 (al)2.6 (l)2.6 (y)8.9 ( )]TJ 0 -1.37 Td [(i)2.6 (nv)8.8 (as)-2 (i)-8.3 (v)8.9 (e f)-17.5 (ol)2.6 (l)2.7 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (as)-2 ( and)10.5 ( N)2.6 (I)-6.6 (F)11.2 (T)-10.6 (P)12.9 ( us)-2 (ual)2.6 (l)2.6 (y)8.9 ( hav)8.9 (e an ex)8.9 (c)-2 (el)2.6 (l)2.6 (ent)-6.6 ( )]TJ 0 -1.38 Td [(pr)-6 (o)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)-2 (.)4.3 ( H)2.6 (ow)13.5 (e)-11.2 (v)8.9 (er)-5.9 (,)-6.6 ( dea)10.5 (t)-6.6 (hs)-2 ( a)10.6 (t)-6.7 (t)4.3 (r)-5.9 (i)2.6 (but)-6.6 (ed)10.6 ( t)-6.6 (o)10.6 ( m)-6 (i)2.6 (ni)2.6 (m)-6 (al)2.6 (l)2.6 (y)8.9 ( i)2.6 (nv)8.9 (as)-12.8 (i)-8.3 (v)8.9 (e )11.3 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( )]TJ 0.002 Tw 0 -1.37 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (no)]TJ 0.007 Tw [(m)-5.9 (a)10.5 ( do oc)8.9 (c)-2 (as)-2 (i)2.6 (onal)2.6 (l)2.7 (y)8.8 ( oc)-2 (c)-2 (ur)-5.9 (.)-6.6 ( Fo)10.5 (r)-6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (h)-11.2 (o hav)8.9 (e a c)-2 (en)10.5 (t)-6.6 (r)-5.9 (al)2.6 ( nec)8.9 (k)-2 ( )]TJ 0 -1.37 Td [(r)-6 (ec)-2 (ur)5 (r)-6 (enc)-2 (e,)4.2 ( pr)-6 (eope)10.5 (r)-6 (at)-6.6 (i)2.6 (v)8.9 (e v)8.9 (oc)-2 (al)2.6 ( c)-2 (or)-6 (d as)8.9 (s)-2 (es)-2 (s)8.9 (m)-5.9 (ent)4.2 ( )11.3 (s)-2 (houl)2.7 (d be c)-2 (ons)-2 (i)2.6 (der)-5.9 (ed)10.6 ( )]TJ 0.002 Tw 0 -1.38 Td [(\()-6 (s)-2 (ee )]TJ /TT2 1 Tf 0.007 Tw 2.228 0 Td [(R)2.6 (ec)-2 (u)10.5 (r)-6 (r)-5.9 (en)10.6 (t)-6.6 ( D)2.7 (i)2.6 (s)-2 (eas)-2 (e)]TJ /TT0 1 Tf 0 Tc 0 Tw 8.239 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (n t)-6.6 (he)10.5 ( N)2.6 (C)2.7 (C)2.6 (N)2.6 ( G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2.1 ( )11.3 (f)-6.6 (or)-6 ( Fol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( [)4.3 (T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d])4.3 ( )]TJ 0.002 Tw -10.75 -1.37 Td [(C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a\))4.9 (.)-6.6 ( )]TJ 0 Tc 0 Tw 5.707 0 Td ( )Tj EMC /P <>BDC -0.002 Tc -0.004 Tw -5.707 -2.38 Td [(T)-10.6 (he)10.5 ( )-10.6 (ot)-6.7 (he)10.5 (r)-5.9 ( f)-6.6 (eat)-6.6 (u)10.6 (r)-6 (es)-2 ( )-10.6 (o)10.6 (f)-6.6 ( m)-5.9 (a)10.5 (nag)-11.2 (e)10.5 (m)-6 (ent)4.3 ( )-10.6 (and f)-6.6 (ol)2.6 (l)]TJ 0.002 Tw 18.837 0 Td (ow)Tj 0 Tc 0 Tw 1.261 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up f)-6.6 (or)5 ( )11.2 (f)-17.4 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ -20.435 -1.37 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( ar)-5.9 (e)10.5 ( s)-2 (i)2.6 (m)-5.9 (i)2.6 (l)2.6 (ar)-5.9 ( )11.2 (t)-6.6 (o )11.2 (t)-6.6 (hos)-2.1 (e o)10.5 (f)-6.6 ( P)12.8 (T)-10.5 (C)13.5 (.)-6.7 ( C)2.6 (l)2.7 (i)2.6 (ni)2.6 (c)-2 (opat)4.3 (hol)2.6 (og)-11.2 (i)2.6 (c)-2 ( )11.3 (f)-6.6 (ac)-2 (t)-6.6 (o)10.5 (r)-5.9 (s)-2 ( )11.3 (c)-2 (an be)10.5 ( )]TJ 0 -1.38 Td [(us)-2 (ed t)-6.7 (o)10.6 ( )11.2 (g)-11.2 (ui)2.6 (de dec)-2 (i)2.6 (s)-2 (i)2.6 (ons)-2 ( )11.3 (about)-6.6 ( w)13.5 (het)-6.6 (her)4.9 ( t)-6.6 (o)10.5 ( adm)-6 (i)2.7 (ni)13.5 (s)-2 (t)-6.6 (er)5 ( i)2.7 (ni)2.6 (t)-6.6 (i)2.6 (al)2.6 ( pos)-2 (t)-6.6 (ope)10.5 (r)-5.9 (at)-6.6 (i)2.6 (v)8.9 (e )]TJ -0.013 Tc 0.018 Tw 0 -1.37 Td [(R)-8.4 (A)-9 (I)-17.6 ( \()-16.9 (s)-13 (e)-11.4 (e )]TJ /TT2 1 Tf -0.002 Tc 0.007 Tw [(C)2.6 (l)2.6 (i)2.6 (ni)2.7 (c)-2.1 (opat)-6.6 (hol)2.6 (ogi)2.6 (c)-2 ( Fac)-2 (t)-6.6 (o)10.5 (r)-5.9 (s)]TJ /TT0 1 Tf 0 Tc 0 Tw 15.293 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(i)2.6 (n t)-6.6 (he )-10.6 (N)2.6 (C)2.6 (C)2.7 (N)2.6 ( G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( f)-17.5 (or)4.9 ( )-10.6 (Fol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( )]TJ 0.002 Tw -15.576 -1.38 Td [([)4.3 (T)-10.6 (hy)8.9 (r)-5.9 (oi)2.6 (d)]TJ -0.005 Tc 0.01 Tw [(])-9.6 ( Ca)-3.4 (r)-9 (c)-5 (in)-3.3 (o)7.5 (m)-9 (a)]TJ 0 Tc 0 Tw 8.978 0 Td (\))Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(.)-6.6 ( )11.3 (T)-10.6 (h)10.5 (e N)2.6 (C)2.6 (C)2.6 (N)2.6 ( G)-6.6 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( pr)-5.9 (ov)8.9 (i)2.6 (de )]TJ 0.002 Tw [(al)2.6 (g)-11.2 (or)-5.9 (i)13.5 (t)-6.7 (hm)-6 (s)]TJ 0 Tc 0 Tw 18.837 0 Td ( )Tj 0.005 Tc -0.005 Tw 0.283 0 Td (to)Tj 0 Tc 0 Tw 0.826 0 Td ( )Tj 0.283 0 Td [(a)1.7 (ssi)4.6 (s)10.8 (t)-4.6 ( )]TJ -0.002 Tc 0.007 Tw -29.533 -1.37 Td [(i)2.6 (n dec)-2 (i)2.6 (s)-2 (i)2.6 (on)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 5.043 0 Td [(m)-6 (a)10.6 (k)-12.9 (i)2.6 (n)10.5 (g)-11.2 ( abou)10.5 (t)4.3 ( us)-2 (e o)10.5 (f)-6.6 ( R)2.6 (A)12.8 (I)-6.6 ( i)2.6 (n di)13.5 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.6 (t)4.2 ( s)8.9 (et)-6.6 (t)-6.6 (i)2.6 (n)10.5 (g)-11.2 (s)-2 (:)4.3 ( 1\))5 ( R)2.6 (A)1.9 (I)4.3 ( i)2.6 (s)-2 ( no)10.6 (t)-6.6 ( )]TJ -5.043 -1.38 Td [(t)-6.6 (y)8.9 (pi)2.6 (c)-2 (al)2.6 (l)-8.3 (y)8.9 ( i)2.6 (ndi)2.6 (c)-2 (at)-6.6 (ed )11.2 (f)-17.4 (or)4.9 ( pat)4.3 (i)2.6 (ent)-6.6 (s)-2 ( c)-2 (l)2.6 (as)-2 (s)-2 (i)13.5 (f)-17.5 (i)2.6 (ed a)10.5 (s)-2 ( hav)8.9 (i)2.6 (ng a l)2.6 (ow)13.5 ( r)-6 (i)2.6 (s)-2 (k)-2 ( o)10.6 (f)-6.7 ( )]TJ 0.002 Tw 0 -1.37 Td [(r)-6 (ec)-2 (ur)5 (r)-6 (enc)-2 (e/)-6.6 (di)2.6 (s)-2 (eas)-2 (e)]TJ 0 Tc 0 Tw 8.478 0 Td (-)Tj -0.005 Tc 0.01 Tw 0.337 0 Td [(s)-5 (p)-3.3 (e)-3.4 (c)5.9 (if)-20.5 (ic)-5 ( )11.2 (m)-8.9 (o)7.5 (r)-9 (t)-9.6 (a)-3.3 (lit)-9.6 (y)5.8 (;)-9.6 ( 2)7.5 (\))-9 ( RA)-1 (I)1.2 ( )11.3 (m)-9 (a)-3.3 (y)5.8 ( b)-3.3 (e)]TJ 0 Tc 0 Tw 14.283 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(c)-2 (ons)-2 (i)2.6 (der)-5.9 (ed)10.6 ( f)-17.5 (o)10.6 (r)-6 ( )]TJ 0.007 Tw -23.38 -1.38 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (hout)4.3 ( )11.3 (g)-11.2 (r)-6 (os)-2 (s)8.8 ( r)-5.9 (e)10.5 (s)-2 (i)2.6 (dual)2.6 ( di)2.6 (s)-2 (eas)-2 (e,)-6.6 ( bu)10.6 (t)-6.7 ( da)10.5 (t)-6.6 (a )11.2 (ar)-6 (e c)-2 (on)10.5 (f)-17.4 (l)2.6 (i)2.6 (c)8.9 (t)-6.6 (i)2.6 (ng r)-6 (e)10.5 (g)-11.2 (a)10.6 (r)-6 (di)2.6 (n)10.6 (g)-11.2 ( )]TJ 0 -1.37 Td [(t)-6.6 (he bene)10.6 (f)-17.5 (i)13.5 (t)-6.6 ( o)10.5 (f)-6.6 ( R)2.6 (A)12.8 (I)-6.6 ( i)2.6 (n )11.2 (t)-6.6 (hi)2.6 (s)-2 ( )11.2 (s)-2 (et)-6.6 (t)-6.6 (i)2.6 (n)10.5 (g)-11.2 (;)4.3 ( and)10.5 ( 3\))4.9 ( R)2.6 (A)1.9 (I)-6.6 ( i)2.6 (s)8.9 ( o)10.5 (f)-6.6 (t)4.3 (en us)-2 (ed )11.3 (f)-6.6 (or)5 ( pat)-6.7 (i)2.7 (en)10.5 (t)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ EMC ET endstream endobj 828 0 obj 26565 endobj %% Contents for page 90 %% Original object ID: 181 0 829 0 obj << /Length 830 0 R >> stream Q q BT /Xi88 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 830 0 obj 245 endobj %% Contents for page 91 %% Original object ID: 182 0 831 0 obj << /Length 832 0 R >> stream q endstream endobj 832 0 obj 2 endobj %% Contents for page 91 %% Original object ID: 11426 0 833 0 obj << /Length 834 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 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(t)-6.6 (i)2.6 (n)10.5 (g)-11.2 ( )11.3 (t)-6.6 (hes)-2 (e )11.3 (c)-2 (r)-6 (i)2.7 (t)-6.7 (e)10.6 (r)-6 (i)2.6 (a )]TJ 0 -1.37 Td [(m)-6 (ay)8.9 ( be )11.2 (f)-17.4 (ol)2.6 (l)2.6 (ow)13.5 (ed w)13.5 (i)2.6 (t)-6.7 (hout)-6.6 ( R)2.6 (A)2 (I)-6.7 ( abl)2.6 (at)-6.6 (i)2.6 (on.)4.3 ( I)-6.6 (odi)2.6 (ne 131)10.5 ( )11.3 (abl)2.6 (a)]TJ [(t)-6.6 (i)2.6 (on and )]TJ 0.002 Tw 0 -1.38 Td [(pos)-2 (t)]TJ 0 Tc 0 Tw 1.891 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( i)13.5 (m)-6 (a)10.6 (g)-11.3 (i)2.7 (ng \()4.9 (w)2.6 (i)2.6 (t)-6.6 (h c)-2 (ons)-2 (i)2.6 (der)-6 (a)10.5 (t)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( dos)8.9 (i)2.6 (m)-5.9 (et)-6.6 (r)-5.9 (y)8.8 ( )11.3 (f)-6.6 (or)5 ( di)2.6 (s)-2 (t)-6.6 (ant)4.3 ( )]TJ -2.217 -1.37 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (i)2.6 (s)-2 (\))4.9 ( ar)-5.9 (e)10.5 ( r)-6 (e)10.6 (c)-2 (om)4.9 (m)5 (ended )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( s)-2 (us)8.9 (pec)-2 (t)-6.6 (ed)10.6 ( or)4.9 ( p)10.5 (r)-5.9 (ov)8.8 (en )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 293.76 415.8 Tm (131)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 305.28 411.84 Tm (I)Tj 0.283 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(av)8.8 (i)2.6 (d m)-6 (et)-6.6 (as)-2 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( )]TJ -26.141 -1.38 Td [(f)-6.6 (oc)-2 (i)2.7 ( \()4.9 (s)-2 (ee )]TJ /TT2 1 Tf [(R)2.6 (A)1.9 (I)4.3 ( B)2 (ei)2.6 (ng C)2.6 (on)10.5 (s)-2 (i)2.6 (der)-5.9 (ed )]TJ [(B)1.9 (as)-2 (ed on)10.6 ( C)2.6 (l)2.6 (i)2.6 (ni)2.7 (c)-2 (opat)-6.6 (hol)2.6 (ogi)2.6 (c)-2 ( Feat)-6.6 (u)10.6 (r)-6 (es)]TJ /TT0 1 Tf 0 Tc 0 Tw 30.413 0 Td ( )Tj -0.013 Tc 0.013 Tw 0.283 0 Td [(i)-8.4 (n )]TJ -0.002 Tc 0.007 Tw -30.696 -1.37 Td [(t)-6.6 (he N)2.6 (C)2.6 (C)2.6 (N)2.6 ( G)4.3 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( )11.2 (f)-17.4 (or)5 ( Fol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( [)]TJ 15.783 0 Td [(T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d])-6.6 ( C)2.6 (ar)4.9 (c)-2 (i)2.6 (nom)-6 (a\))4.9 (.)-6.6 ( )11.3 (T)-10.6 (he)10.5 ( dec)-2 (i)2.6 (s)-2 (i)2.6 (on t)4.3 (o )]TJ -15.783 -1.38 Td [(per)4.9 (f)-17.5 (o)10.6 (r)-6 (m)4.9 ( di)2.6 (ag)-11.2 (no)10.5 (s)-2 (t)-6.6 (i)2.6 (c)-2 ( w)13.5 (hol)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 11.413 0 Td [(body)8.8 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 176.4 370.2 Tm (131)Tj 0.005 Tc -0.005 Tw 11.04 -0 0 11.04 187.92 366.24 Tm (I )Tj -0.002 Tc 0.007 Tw 0.565 0 Td [(i)2.6 (m)-5.9 (ag)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( w)13.5 (i)2.6 (t)-6.6 (h a)10.6 (deq)-11.3 (ua)10.5 (t)-6.6 (e )11.2 (T)-10.5 (S)1.9 (H)2.6 ( s)8.9 (t)-6.6 (i)2.6 (m)-5.9 (ul)2.6 (at)-6.6 (i)2.6 (on)10.6 ( )]TJ -15.457 -1.37 Td [(\()-6 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d w)13.5 (i)2.6 (t)-6.6 (hdr)-5.9 (aw)13.5 (al)2.7 ( or)-6 ( r)-5.9 (h)10.5 (T)-10.6 (S)2 (H)2.6 ( s)8.9 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (at)-6.6 (i)2.6 (on\))5 ( be)10.5 (f)-6.6 (or)-6 (e)10.6 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 259.56 355.08 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 271.08 351.12 Tm [(I)-6.6 ( t)-6.6 (her)-6 (apy)8.9 ( i)2.6 (s)-2 ( )]TJ -22.424 -1.38 Td [(adm)-6 (i)2.7 (ni)2.6 (s)-2 (t)-6.6 (er)-6 (ed)10.5 ( i)2.6 (s)-2 ( a)10.5 ( c)-2 (at)-6.6 (e)10.5 (g)-11.2 (o)10.5 (r)-6 (y)8.9 ( 2B)1.9 ( r)-6 (ec)-2 (o)10.5 (m)5 (m)-6 (endat)-6.6 (i)2.6 (on )11.3 (f)4.2 (or)-6 ( bo)10.5 (t)-6.6 (h )11.3 (f)-6.6 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.7 (ar)-5.9 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0.002 Tw 0 -1.37 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)]TJ 0.007 Tw 4.054 0 Td [(a)10.5 ( and P)12.8 (T)-10.6 (C)2.7 ( be)10.5 (c)8.9 (aus)-2 (e o)10.5 (f)-6.6 ( t)-6.7 (he)10.5 ( pr)-6 (obl)2.6 (e)10.6 (m)-6 ( o)10.5 (f)-6.6 ( s)8.9 (t)4.3 (unni)2.6 (ng)-11.2 ( )11.2 (\()-5.9 (s)-2 (ee )11.2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (on)10.6 ( on )]TJ /TT2 1 Tf -4.054 -1.38 Td [(D)2.6 (i)2.6 (agnos)-2 (t)-6.6 (i)2.6 (c)-2 ( Tot)-6.6 (al)2.7 ( B)1.9 (ody)8.9 ( I)4.2 (m)4.9 (agi)2.6 (ng)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj /TT2 1 Tf -0.002 Tc 0.002 Tw 13.793 0 Td (and)Tj /TT0 1 Tf 0 Tc 0 Tw ( )Tj /TT2 1 Tf -0.002 Tc 0.007 Tw 1.946 0 Td [(Thy)-2 (r)-6 (oi)2.6 (d)10.5 ( S)1.9 (t)-6.6 (unni)13.5 (ng)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.005 Tc 0.01 Tw 7.804 0 Td [(in)-3.3 ( t)-9.6 (h)-3.3 (is)5.8 ( Dis)-5 (c)-5 (u)-3.3 (s)-5 (s)-5 (io)-3.4 (n)-3.3 (\))-9 (.)1.3 ( )]TJ 0 Tc 0 Tw 8.576 0 Td ( )Tj EMC /H1 <>BDC /TT1 1 Tf 0.009 Tc 12.96 -0 0 12.96 23.52 278.04 Tm [<48fc7274>-0.6 (hle Cell Carcinoma )]TJ 0 Tc ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 259.44 Tm [(T)-10.6 (hi)2.6 (s)-2 ( )11.3 (t)-6.6 (u)10.5 (m)-6 (or)4.9 ( \()-6 (al)2.6 (s)-2 (o )11.2 (k)-2 (now)13.5 (n as)-2 ( ox)8.8 (y)8.9 (phi)-8.3 (l)2.7 (i)2.6 (c)-2 ( c)-2 (el)2.6 (l)2.6 ( c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a\))]TJ 0 Tc 0 Tw 22.707 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (s)-2 ( us)-2 (ual)2.6 (l)2.6 (y)8.8 ( as)-2 (s)-2 (um)-6 (ed)10.5 ( t)4.2 (o )]TJ -22.989 -1.38 Td [(be a v)8.8 (ar)-6 (i)2.6 (ant)-6.6 ( o)10.6 (f)-6.7 ( )11.3 (f)-6.6 (ol)2.7 (l)2.6 (i)2.6 (c)-2 (ul)]TJ 9.359 0 Td [(ar)-6 ( t)4.3 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.7 (nom)-6 (a)]TJ 0 Tc 0 Tw 9.033 0 Td (,)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 229.68 248.16 Tm [(202,)-1.8 (4)-17 (08)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 254.76 244.2 Tm ( )Tj -0.005 Tc 0.005 Tw 0.283 0 Td [(a)-14.2 (lt)-9.6 (h)-3.4 (o)]TJ -0.013 Tc 0.018 Tw 2.174 0 Td [(u)-11.3 (g)-22.3 (h t)-17.6 (h)-11.3 (e p)-11.3 (r)-17 (og)-22.2 (n)-11.4 (os)-13 (i)-8.4 (s)-13 ( of)-17.6 ( )]TJ -0.005 Tc 0.01 Tw -23.402 -1.37 Td [<48fc>-3.4 (r)-8.9 (t)-9.6 (h)-3.4 (le)-3.3 ( c)-5.1 (e)-3.3 (ll c)-5 (a)7.5 (r)-9 (c)-5 (in)-3.3 (o)-3.4 (m)-8.9 (a)7.5 ( is)-5 ( )]TJ -0.002 Tc 0.002 Tw [(w)13.4 (or)-6 (s)-2 (e.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 178.92 233.04 Tm [(177,)-1.8 (4)-17 (04)-17 (,)-1.8 (40)-16.9 (6,)-19.1 (409)-17 (,)-1.8 (4)-17 (10)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 244.92 229.08 Tm ( )Tj -0.002 Tc 0.007 Tw 0.293 0 Td [(M)15.8 (ol)-8.2 (ec)-2 (ul)2.6 (ar)-5.9 ( di)2.7 (a)10.5 (g)-11.2 (nos)-2 (t)-6.6 (i)2.6 (c)8.9 ( t)-6.6 (es)8.9 (t)-6.7 (i)2.7 (ng )]TJ -20.348 -1.38 Td [(m)-6 (ay)8.9 ( not)-6.6 ( pe)10.5 (r)5 (f)-17.5 (o)10.5 (r)4.9 (m)-5.9 ( w)13.4 (el)2.6 (l)2.6 ( f)-17.5 (o)10.5 (r)-5.9 ( )]TJ 10.967 0 Td [(H)2.6 -6 (t)-6.6 (hl)2.7 (e c)-2 (el)2.6 (l)]TJ 0 Tc 0 Tw 4.989 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(neopl)2.6 (as)-2 (m)4.9 ( as)8.9 ( di)2.6 (s)-2 (c)-2 (us)-2 (s)-2 (ed i)2.6 (n)10.6 ( )]TJ /TT2 1 Tf -0.005 Tc 0.005 Tw [(F)-2.7 (NA)-1.1 ( )]TJ -16.239 -1.37 Td [(Re)-3.4 (s)-5 (u)-3.3 (lt)-9.6 (s)]TJ /TT0 1 Tf -0.002 Tc 0.007 Tw 3.326 0 Td [(,)-6.6 ( abov)8.9 (e.)4.2 ( )]TJ 3.815 0 Td [(T)-10.6 (he H)2.7 10.5 (r)-6 (t)4.3 (hl)2.6 (e c)-2 (el)2.7 (l)2.6 ( v)8.8 (ar)-6 (i)2.6 (ant)-6.7 ( o)10.6 (f)]TJ 0 Tc 0 Tw 11.359 0 Td ( )Tj -0.016 Tc 0.016 Tw 0.283 0 Td [(P)-12.1 (T)-24.5 (C)-0.6 ( )]TJ 0.004 Tc -0.01 Tw 2.272 0 Td [(i)8.6 (s)4 ( ra)5.7 (re)16.5 ( )]TJ -0.002 Tc 0.007 Tw 3.043 0 Td [(and s)-2 (ee)10.5 (m)-5.9 (s)8.8 ( t)-6.6 (o)10.6 ( hav)8.8 (e )]TJ -24.098 -1.38 Td [(a pr)-5.9 (o)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)8.8 ( s)-2 (i)2.6 (m)-5.9 (i)2.6 (l)2.6 (ar)-6 ( )11.3 (t)-6.6 (o )11.3 (f)-6.6 (ol)2.6 (l)2.6 (i)2.7 (c)-2 (ul)2.6 (ar)-6 ( c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (a.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 227.88 187.44 Tm (411)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 239.4 183.48 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.013 Tc 0.018 Tw -19.837 -2.37 Td [(T)-21.6 (h)-11.3 (e m)-17 (a)-11.3 (n)-11.4 (ag)-22.3 (em)-17 (e)]TJ -0.002 Tc 0.007 Tw 6.989 0 Td [(nt)4.2 ( o)10.5 (f)-6.6 ( H)2.6 4.9 (t)4.3 (hl)2.6 (e c)-2 (el)2.6 (l)2.6 ( c)-1.9 (ar)-6 (c)-2 (i)2.6 (nom)-6 (a)10.5 ( i)2.6 (s)-2 ( al)2.6 (m)4.9 (os)-2 (t)-6.6 ( i)2.6 (dent)-6.6 (i)2.6 (c)-2 (al)2.6 ( )11.3 (t)-6.7 (o )11.3 (f)-6.7 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( )]TJ -6.989 -1.37 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)]TJ 5.163 0 Td [(i)2.6 (nom)4.9 (a,)4.2 ( ex)8.9 (c)-2 (ept)-6.6 ( )11.2 (t)-6.6 (hat)4.3 ( 1\))5 ( l)2.6 (oc)-2 (or)-6 (e)10.5 (g)-11.2 (i)2.6 (onal)2.6 ( nod)10.5 (al)2.6 ( m)-6 (et)-6.6 (a)10.5 (s)-2 (t)-6.6 (as)-2 (es)8.9 ( )11.2 (m)-5.9 (ay)8.9 ( be )]TJ -5.163 -1.38 Td [(m)-6 (or)-6 (e)10.6 ( c)-2 (om)4.9 (m)-5.9 (on)10.5 (,)-6.6 ( and)10.6 ( t)-6.6 (he)10.5 (r)4.9 (e)10.6 (f)-17.5 (or)-6 (e)10.5 ( t)-6.6 (he)10.5 (r)-6 (apeut)-6.6 (i)2.6 (c)8.9 ( l)2.6 (y)8.9 (m)-6 (ph )11.3 (node di)2.6 (s)-2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (ons)8.9 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.5 ( )]TJ -0.004 Tw 0 -1.37 Td [(a)10.5 (f)-6.6 (f)-17.5 (ec)8.9 (t)-6.7 (ed c)-2 (om)-6 (pa)10.5 (r)-6 (t)4.3 (m)-6 (ent)4.2 ( m)4.9 (ay)8.9 ( )-10.6 (be )-10.6 (needed f)-17.5 (o)10.5 (r)-5.9 ( c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 (l)-8.3 (y)8.9 ( )-10.6 (appar)-5.9 (ent)-6.6 ( )-10.6 (bi)2.6 (ops)-2 (y)]TJ 0 Tc 0 Tw 29.576 0 Td (-)Tj -0.002 Tc 0.007 Tw -29.576 -1.38 Td [(pr)-6 (ov)8.9 (en di)2.6 (s)-2 (eas)-2 (e;)-6.6 ( and)10.6 ( 2\))4.9 ( )11.3 (m)-6 (et)-6.6 (as)8.9 (t)-6.6 (at)-6.7 (i)2.7 (c)8.8 ( H)2.6 4.9 (t)-6.6 (hl)2.6 (e c)-2 (el)2.6 (l)2.6 ( t)-6.6 (u)10.5 (m)-6 (or)-6 (s)8.9 ( ar)-5.9 (e)10.5 ( l)2.6 (es)-2 (s)]TJ 0 Tc 0 Tw 27.315 0 Td ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(li)10.5 (k)-15.9 (e)-3.3 (ly)5.8 ( t)-9.6 (o)-3.4 ( )]TJ -0.002 Tc 0.002 Tw -27.598 -1.37 Td [(c)-2 (onc)-2 (ent)-6.6 (r)-5.9 (a)10.5 (t)-6.6 (e )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 84.24 85.44 Tm (131)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 95.76 81.48 Tm (I)Tj 0.283 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.272 0 Td [(\()-6 (s)-2 (ee )]TJ /TT2 1 Tf 0.007 Tw 2.228 0 Td [(P)2 (ap)10.5 (i)2.6 (l)2.7 (l)2.6 (ar)-5.9 (y)-2 ( Thy)-2 (r)-5.9 (oi)2.6 (d C)2.6 (anc)-2 (er)]TJ /TT0 1 Tf 0.005 Tc -0.005 Tw 10.902 0 Td (: )Tj /TT2 1 Tf -0.002 Tc 0.007 Tw 0.565 0 Td [(S)2 (u)10.5 (r)-6 (gi)2.6 (c)-2 (al)2.7 ( Ther)-6 (apy)]TJ /TT0 1 Tf 0 Tc 0 Tw 7.522 0 Td ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(in)-3.3 ( t)-9.6 (h)-3.3 (is)5.8 ( )]TJ 0 Tc 0 Tw -28.598 -1.38 Td [(D)4.6 (i)4.6 (scu)1.7 (ssi)4.6 (o)1.6 (n)1.7 (\))]TJ 5.152 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 83.52 70.2 Tm (412)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 95.04 66.24 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(P)2 (os)-2 (t)-6.6 (oper)4.9 (at)-6.6 (i)2.6 (v)8.9 (e )0.5 (E)1.9 (B)2 (R)2.6 (T)-10.6 ( or)4.9 ( I)-6.6 (M)15.7 (R)2.7 (T)-10.6 ( )11.3 (c)-2 (an )11.2 (be c)-2 (ons)-2 (i)2.7 (der)-6 (ed)10.5 ( )11.3 (f)-17.5 (o)10.5 (r)-6 (:)4.3 ( 1\))4.9 ( )]TJ -6.761 -1.37 Td [(unr)-6 (es)-2 (ec)-2 (t)-6.7 (abl)2.6 (e)10.5 ( pr)-5.9 (i)2.6 (m)-6 (a)]TJ 8.478 0 Td [(r)-6 (y)8.9 ( H)2.6 -6 (t)-6.6 (hl)2.6 (e c)-2 (el)2.6 (l)2.6 ( l)2.6 (es)-2 (i)2.6 (ons)-2 ( )11.2 (t)-6.6 (hat)4.3 ( do)10.5 ( )11.2 (not)-6.7 ( c)-2 (onc)-2 (en)10.5 (t)-6.6 (r)-5.9 (a)10.5 (t)-6.6 (e)10.5 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 340.32 55.08 Tm (131)Tj 0.005 Tc 0 Tw 11.04 -0 0 11.04 351.84 51.12 Tm [(I i)9.6 (f )]TJ -0.002 Tc 0.007 Tw 4.815 41.924 Td [(di)2.6 (s)-2 (eas)-2 (e i)2.6 (s)-2 ( t)-6.6 (h)10.5 (r)-5.9 (eat)-6.6 (eni)2.6 (n)10.5 (g v)8.9 (i)2.6 (t)-6.7 (al)2.6 ( s)-2 (t)-6.6 (r)-6 (u)10.6 (c)-2 (t)-6.6 (u)10.5 (r)-6 (es)-2 (;)4.2 ( and 2)10.5 (\))-5.9 ( un)10.5 (r)-5.9 (e)10.5 (s)-2 (ec)-2 (t)-6.7 (abl)2.6 (e l)2.6 (oc)-2 (or)-5.9 (e)10.5 (g)-11.2 (i)2.6 (onal)2.6 ( )]TJ -0.004 Tw 0 -1.38 Td [(r)-6 (ec)-2 (ur)5 (r)-6 (enc)-2 (e \()-5.9 (s)-2 (ee)10.6 ( )]TJ /TT2 1 Tf 0.007 Tw 7.261 0 Td [(P)2 (os)-2 (t)-6.6 (s)-2 (u)10.5 (r)5 (gi)2.6 (c)-2 (al)2.6 ( E)1.9 (v)-2 (al)2.6 (uat)-6.6 (i)2.6 (on)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.002 Tc 0.002 Tw 10.63 0 Td (and )Tj /TT2 1 Tf 0.007 Tw 1.946 0 Td [(R)2.6 (ec)8.8 (ur)-6 (r)-5.9 (en)10.6 (t)-6.6 ( D)2.7 (i)2.6 (s)-2 (eas)-2 (e)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.013 Tc 0.018 Tw 8.533 0 Td [(i)-8.4 (n t)-17.6 (h)-11.3 (e )]TJ -0.002 Tc 0.007 Tw -28.37 -1.37 Td [(N)2.6 (C)2.6 (C)2.6 (N)2.6 ( G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (or)4.9 ( H)2.6 -5.9 (t)-6.6 (hl)2.6 (e C)2.6 (el)2.7 (l)2.6 ( [)4.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d])4.3 ( C)2.6 (ar)-6 (c)-2 (i)13.5 (nom)-5.9 (a\))4.9 (,)-6.6 ( s)-2 (i)13.5 (m)-6 (i)2.6 (l)2.7 (ar)-6 ( t)-6.6 (o)10.6 ( )11.2 (t)-6.6 (he )]TJ -0.004 Tw 0 -1.38 Td [(m)-6 (ana)10.6 (g)-11.2 (em)-5.9 (en)10.5 (t)-6.6 ( f)-6.6 (or)5 ( f)-6.6 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (a)-11.2 (r)-5.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (c)-2 (ar)-6 (c)-2 (i)2.6 (nom)4.9 (a.)]TJ 0 Tc 0 Tw 6.96 -0 0 6.96 621.6 472.32 Tm (3)Tj 11.04 -0 0 11.04 625.44 468.36 Tm ( )Tj 0.272 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -20.239 -2.37 Td [(C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (opat)-6.6 (hol)2.7 (og)-11.2 (i)2.6 (c)-2 ( )11.3 (f)-17.5 (ac)8.8 (t)-6.6 (or)-6 (s)8.9 ( )11.3 (c)-2 (an be us)-2 (ed)10.5 ( )11.3 (t)-6.7 (o )11.3 (g)-11.3 (ui)2.6 (de de)10.5 (c)-2 (i)2.6 (s)-2 (i)2.6 (ons)-2 ( about)-6.6 ( w)13.5 (het)-6.6 (her)4.9 ( t)-6.6 (o)10.5 ( )]TJ 0 -1.38 Td [(us)-2 (e i)2.6 (ni)2.6 (t)-6.6 (i)2.6 (al)2.7 ( pos)-2 (t)-6.6 (ope)10.6 (r)-6 (at)-6.6 (i)2.6 (v)8.8 (e R)2.6 (A)1.9 (I)-6.5 ( \()-6 (s)-2 (ee)10.6 ( )]TJ /TT2 1 Tf [(C)2.6 (l)2.6 (i)2.6 (ni)2.7 (c)-2 (opat)-6.6 (hol)2.6 (ogi)2.6 (c)-2 ( Fac)-2 (t)-6.6 (o)10.5 (r)-5.9 (s)]TJ /TT0 1 Tf 0 Tc 0 Tw 25.989 0 Td ( )Tj -0.005 Tc -0.001 Tw 0.283 0 Td [(in)-3.3 ( t)-9.6 (h)-3.4 (e)-3.3 ( )-10.6 (NCCN )]TJ -0.002 Tc 0.007 Tw -26.272 -1.37 Td [(G)-6.6 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (or)5 ( H)2.7 4.9 (t)-6.6 (hl)2.6 (e C)13.5 (el)2.6 (l)2.6 ( [)-6.6 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d])4.3 ( C)2.7 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a)]TJ 0 Tc 0 Tw 20.88 0 Td (\))Tj -0.005 Tc -0.001 Tw 0.337 0 Td [(.)1.3 ( T)-13.6 (h)-3.3 (e)-3.4 ( )-10.6 (NCCN G)-9.6 (u)-3.4 (id)-3.3 (e)-3.4 (lin)-3.3 (e)-3.4 (s)-5 ( )]TJ -0.002 Tc 0.002 Tw -21.217 -1.38 Td [(pr)-6 (ov)8.9 (i)2.6 (de)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.002 Tw 3.543 0 Td [(al)2.6 (g)-11.2 (or)]TJ -0.005 Tc 0.01 Tw 2.228 0 Td [(it)-9.6 (h)7.5 (m)-9 (s)5.9 ( t)-9.6 (o)7.5 ( a)-3.4 (s)-5 (s)5.9 (is)-5 (t)-9.6 ( in)-3.3 ( d)-3.4 (e)-3.3 (c)-5 (is)-5 (io)-3.4 (n)]TJ 0 Tc 0 Tw 11.293 0 Td (-)Tj -0.013 Tc 0.018 Tw 0.326 0 Td [(m)-17 (ak)-23.9 (i)-8.4 (ng)-22.2 ( a)-11.4 (bo)-11.4 (u)-11.3 (t)-17.6 ( u)-11.4 (s)-13 (e of)-17.5 ( R)-8.4 (A)-9 (I)-6.7 ( i)-8.4 (n)-11.4 ( )]TJ -0.002 Tc 0.007 Tw -17.391 -1.37 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 ( s)-2 (e)10.5 (t)4.3 (t)-6.6 (i)2.6 (ng)-11.2 (s)8.9 (:)-6.6 ( 1)10.5 (\))-5.9 ( R)2.6 (A)12.8 (I)-6.6 ( )11.3 (i)2.6 (s)-2 ( not)-6.6 ( )11.2 (t)-6.6 (y)8.9 (pi)2.7 (c)-2 (al)2.6 (l)-8.2 (y)8.8 ( i)2.6 (ndi)2.6 (c)-2 (at)-6.6 (ed )11.3 (f)-6.6 (or)-5.9 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( )11.3 (c)-2 (l)2.6 (as)-2 (s)-2 (i)13.4 (f)-17.4 (i)2.6 (ed as)8.9 ( )]TJ 0 -1.38 Td [(hav)8.9 (i)2.6 (ng)-11.2 ( a l)2.6 (ow)13.5 ( r)-5.9 (i)2.6 (s)-2 (k)-2 ( o)10.5 (f)-6.6 ( r)-6 (e)10.5 (c)-2 (ur)4.9 (r)-6 (enc)-2 (e/)-6.6 (di)2.6 (s)-2 (eas)-2 (e)]TJ 0 Tc 0 Tw 17.228 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(s)-2 (pec)-2 (i)13.5 (f)-17.5 (i)2.6 (c)8.9 ( m)4.9 (or)-6 (t)-6.6 (al)2.7 (i)2.6 (t)-6.6 (y)8.8 (;)-6.6 ( 2)10.5 (\))-5.9 ( R)2.6 (A)2 (I)4.2 ( m)-5.9 (ay)8.9 ( be)10.6 ( )]TJ -17.565 -1.37 Td [(c)-2 (ons)-2 (i)2.6 (der)-5.9 (ed )11.3 (f)-6.7 (or)4.9 ( pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( w)13.5 (i)2.6 (t)-6.7 (hout)-6.6 ( )11.3 (gr)-5.9 (os)-2 (s)8.9 ( r)-6 (es)-2 (i)2.6 (dual)]TJ 0 Tc 0 Tw 20 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(di)2.6 (s)-2 (e)10.5 (as)-1.9 (e,)-6.6 ( bu)10.6 (t)-6.6 ( da)10.5 (t)-6.6 (a a)10.5 (r)-6 (e )]TJ -20.283 -1.38 Td [(c)-2 (on)10.5 (f)-17.5 (l)2.6 (i)2.6 (c)-2 (t)-6.6 (i)2.6 (ng r)-5.9 (e)10.5 (g)-11.2 (a)10.5 (r)-6 (di)2.6 (n)10.5 (g)-11.2 ( )11.3 (t)-6.6 (he )11.2 (bene)10.5 (f)-17.4 (i)2.6 (t)-6.7 ( )0.5 (o)10.5 (f)-6.6 ( R)2.6 (A)12.8 (I)-6.6 ( i)2.6 (n )11.3 (t)-6.6 (hi)2.6 (s)-2 ( s)-2 (e)10.5 (t)-6.6 (t)-6.6 (i)13.4 (ng;)-6.7 ( )0.5 (and)10.5 ( 3\))4.9 ( R)2.6 (A)2 (I)-6.6 ( i)2.6 (s)8.9 ( o)10.5 (f)-6.6 (t)-6.6 (en )]TJ 0 -1.37 Td [(us)-2 (ed )11.2 (f)-17.5 (o)10.6 (r)-6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h k)-12.9 (n)10.5 (ow)13.5 (n or)-6 ( s)-2 (us)-2 (pec)-2 (t)-6.6 (ed)10.5 ( di)2.6 (s)-2 (t)-6.6 (an)10.5 (t)4.2 ( m)-5.9 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (a)10.6 (t)-6.6 (i)2.6 (c)-2 ( di)2.6 (s)-2 (eas)-2 (e)]TJ 0 Tc 0 Tw 30.304 0 Td ( )Tj -0.013 Tc 0.013 Tw 0.283 0 Td [(\()-17 (s)-13 (ee)-11.4 ( )]TJ /TT2 1 Tf -0.002 Tc 0.007 Tw -30.587 -1.38 Td [(C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (opat)-6.6 (hol)2.7 (ogi)2.6 (c)-2 ( Fac)-2 (t)-6.6 (or)4.9 (s)]TJ /TT0 1 Tf 0 Tc 0 Tw 11.13 0 Td ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(in)-3.4 ( t)-9.6 (h)-3.3 (e)7.5 ( NCCN G)-9.6 (u)-3.3 (id)-3.4 (e)-3.3 (lin)-3.3 (e)-3.4 (s)-5 ( )11.2 (f)-20.5 (o)7.6 (r)-9 <2048fc>7.5 (r)-8.9 (t)-9.7 (h)-3.3 (le)-3.4 ( c)-5 (e)-3.3 (ll )11.2 ([)1.3 (T)-13.6 (h)-3.4 (y)5.9 (r)-9 (o)-3.3 (id)-3.4 (])-9.6 ( )]TJ 0.005 Tw -11.413 -1.37 Td [(Ca)-3.4 (r)-8.9 (c)-5 (i)]TJ -0.002 Tc 0.002 Tw [(nom)-6 (a)]TJ 0 Tc 0 Tw (\))Tj 5.152 0 Td (.)Tj 0.272 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -5.424 -2.37 Td [(R)2.6 (A)2 (I)-6.6 ( t)-6.7 (he)10.5 (r)-5.9 (apy)8.9 ( has)-1.9 ( been)10.5 ( r)-5.9 (e)10.5 (por)-6 (t)-6.6 (ed)10.5 ( t)-6.6 (o)10.5 ( dec)-2 (r)-5.9 (ea)10.5 (s)-2 (e )11.3 (t)-6.7 (he )11.2 (r)-5.9 (i)2.6 (s)-2 (k)-2 ( o)10.5 (f)-6.6 ( l)2.6 (oc)-2 (or)-5.9 (e)10.5 (g)-11.2 (i)2.6 (onal)2.6 ( )]TJ 0 -1.38 Td [(r)-6 (ec)-2 (ur)5 (r)-6 (enc)-2 (e and)10.5 ( i)2.6 (s)-2 ( )11.3 (r)-6 (ec)-2 (o)10.5 (m)4.9 (m)-6 (ended )11.3 (f)-6.6 (or)4.9 ( unr)-5.9 (es)-2 (e)10.6 (c)-2 (t)-6.6 (abl)2.6 (e)10.5 ( di)2.6 (s)-2 (eas)-2 (e w)13.5 (i)2.6 (t)-6.6 (h )0.5 (pos)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.8 (e )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 752.28 252.96 Tm (131)Tj 0.016 Tc -0.016 Tw 11.04 -0 0 11.04 763.8 249 Tm [(I)0.5 ( )]TJ -0.002 Tc -0.004 Tw -32.5 -1.37 Td [(i)2.6 (m)-5.9 (ag)-11.2 (i)2.6 (n)10.5 (g)-11.2 (.)4.3 ( I)-6.6 (odi)2.7 (ne )-10.6 (131 t)-6.6 (her)4.9 (apy)8.9 ( )-10.7 (\()-5.9 (100)]TJ 0 Tc 0 Tw <96>Tj -0.002 Tc 0.007 Tw 15.13 0 Td [(150 m)-6 (C)2.6 (i)2.6 (\))4.9 ( )11.3 (m)-6 (ay)8.9 ( be c)-2 (ons)-2 (i)2.6 (der)-6 (ed)10.5 ( a)10.5 (f)-6.6 (t)-6.6 (er)4.9 ( )]TJ -15.13 -1.38 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( )11.3 (f)-17.5 (o)10.5 (r)-6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)4.3 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h s)-2 (t)-6.6 (i)2.6 (m)-5.9 (ul)2.6 (at)-6.6 (ed)]TJ 0 Tc 0 Tw 18.283 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(Tg)-11.2 ( l)2.6 (ev)8.8 (el)2.6 (s)-2 ( o)10.5 (f)-17.5 ( )11.3 (m)-6 (o)10.6 (r)-6 (e )11.2 (t)-6.6 (han 10)10.6 ( n)10.6 (g)-11.2 (/)4.2 (m)-5.9 (L)10.5 ( )]TJ -18.554 -1.37 Td [(w)13.5 (ho hav)8.9 (e neg)-11.2 (at)-6.6 (i)2.7 (v)8.8 (e s)-2 (c)-2 (ans)-2 ( \()-6 (i)2.6 (nc)-2 (l)2.6 (udi)2.6 (ng FD)2.6 (G)]TJ 0 Tc 0 Tw 18.12 0 Td (-)Tj -0.007 Tc 0.012 Tw 0.337 0 Td [(P)-3 (E)7.8 (T)-15.6 (\) \(s)-7 (e)-5.4 (e)-5.3 ( )]TJ /TT2 1 Tf -0.002 Tc 0.007 Tw [(R)2.6 (ec)-2 (ur)4.9 (r)-5.9 (ent)4.2 ( D)2.6 (i)2.6 (s)-2 (eas)-2 (e)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.016 Tc 0.016 Tw 13.293 0 Td [(in)-14.4 ( )]TJ -0.002 Tc 0.007 Tw -31.75 -1.38 Td [(t)-6.6 (he N)2.6 (C)2.6 (C)2.6 (N)2.6 ( G)4.3 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( )11.2 (f)-17.4 (or)5 ( H)2.6 -6 (t)-6.6 (hl)2.6 (e)10.5 ( C)2.6 (el)2.6 (l)2.6 ( [)4.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d])-6.6 ( C)13.5 (ar)-5.9 (c)-2.1 (i)2.7 (nom)-6 (a\))4.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 695.52 192.24 Tm (177)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 707.04 188.28 Tm ( )Tj -0.002 Tc 0.007 Tw -27.359 -1.37 Td [(P)2 (r)-6 (et)-6.7 (r)-5.9 (ea)10.6 (t)4.2 (m)-5.9 (ent)4.2 ( di)2.6 (ag)-11.3 (no)10.5 (s)-2 (t)-6.6 (i)2.6 (c)-2 ( i)13.5 (m)-5.9 (a)10.5 (g)-11.3 (i)2.7 (ng \()]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 569.64 177.12 Tm (123)Tj -0.013 Tc 0.018 Tw 11.04 -0 0 11.04 581.16 173.16 Tm [(I)-17.6 ( or)-17 ( )0.5 (l)-8.4 (o)-11.4 (w)]TJ 0 Tc 0 Tw 3.207 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(dos)-2 (e )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 647.16 177.12 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 658.68 173.16 Tm [(I)-6.6 (\))-6 ( w)13.5 (i)2.6 (t)-6.6 (h adeq)-11.2 (uat)-6.6 (e)10.5 ( )11.3 (T)-10.6 (S)2 (H)2.6 ( )]TJ -22.978 -1.38 Td [(s)-2 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (at)-6.6 (i)2.6 (on )11.2 (\()-5.9 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d w)13.4 (i)2.6 (t)-6.6 (hdr)-6 (aw)13.4 (al)2.6 ( or)-5.9 ( r)-6 (h)10.6 (T)-10.6 (S)1.9 (H)2.6 ( s)8.9 (t)-6.6 (i)2.6 (m)-5.9 (ul)2.6 (at)-6.6 (i)13.4 (o)]TJ [(n\))-6 ( )11.3 (m)-6 (ay)8.8 ( be c)-2 (ons)-2 (i)2.6 (der)-5.9 (ed)10.5 ( )]TJ 0 -1.37 Td [(bas)-2 (ed on pa)10.5 (t)-6.6 (hol)2.6 (o)10.5 (g)-11.2 (y)8.9 (,)-6.6 ( pos)8.8 (t)-6.6 (oper)-6 (a)10.6 (t)-6.7 (i)2.7 (v)8.8 (e Tg)-11.2 (,)4.2 ( and)10.6 ( i)2.6 (nt)-6.6 (r)-5.9 (ao)10.5 (per)-5.9 (at)-6.6 (i)2.6 (v)8.9 (e )11.2 (f)-17.5 (i)2.7 (ndi)2.6 (ng)-11.2 (s)8.9 ( \()4.9 (s)-2 (ee )]TJ /TT2 1 Tf 0 -1.38 Td [(R)2.6 (A)2 (I)-6.6 ( B)1.9 (ei)2.6 (ng C)2.6 (ons)-2 (i)2.6 (der)-5.9 (ed )]TJ [(B)12.8 (as)-2 (ed on C)2.6 (l)2.7 (i)2.6 (ni)2.6 (c)-2 (opat)-6.6 (hol)2.6 (ogi)2.6 (c)-2 ( Feat)-6.6 (u)10.6 (r)-6 (es)]TJ /TT0 1 Tf 0 Tc 0 Tw 26.38 0 Td ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(in)7.5 ( t)-9.6 (h)-3.4 (e)7.6 ( NCCN )]TJ -0.002 Tc 0.007 Tw -26.663 -1.37 Td [(G)-6.6 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (or)4.9 ( H)2.7 4.9 (t)-6.6 (hl)2.6 (e C)13.5 (el)2.6 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For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 836 0 obj 245 endobj %% Contents for page 92 %% Original object ID: 184 0 837 0 obj << /Length 838 0 R >> stream q endstream endobj 838 0 obj 2 endobj %% Contents for page 92 %% Original object ID: 11427 0 839 0 obj << /Length 840 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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-0.002 Tc 0.007 Tw 0.283 0 Td [(B)2 (ec)-2 (aus)-2 (e t)-6.6 (he)10.5 ( )]TJ -27.326 -1.38 Td [(C)2.6 ( c)-2 (el)2.6 (l)2.6 (s)-2 ( ar)-5.9 (e )11.3 (pr)-5.9 (edo)10.5 (m)-5.9 (i)2.6 (nant)-6.6 (l)13.5 (y)8.9 ( l)2.6 (oc)-2 (at)-6.6 (ed i)2.6 (n t)-6.6 (he)10.5 ( upper)4.9 ( po)10.5 (r)-5.9 (t)-6.7 (i)2.7 (on o)10.5 (f)-6.6 ( eac)-2 (h)10.5 ( )11.3 (t)-6.7 (hy)8.9 (r)-6 (o)]TJ [(i)2.6 (d l)2.6 (obe,)-6.6 ( )]TJ 0 -1.37 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h s)-2 (po)10.5 (r)-5.9 (adi)2.6 (c)-2 ( di)13.5 (s)-2 (eas)-2 (e t)-6.7 (y)8.9 (pi)2.6 (c)-2 (al)2.6 (l)2.7 (y)8.8 ( pr)-6 (es)-2 (ent)-6.6 ( w)13.4 (i)2.7 (t)-6.6 (h upper)4.9 ( pol)2.6 (e nodul)2.6 (es)-2 (.)4.2 ( )]TJ 0 -1.38 Td [(M)15.8 (et)-6.6 (as)-2 (t)-6.6 (at)-6.6 (i)2.6 (c)-2 ( c)-2 (er)-6 (v)8.9 (i)2.6 (c)-2 (al)2.6 ( aden)10.5 (opat)-6.6 (hy)8.8 ( appear)-6 (s)8.9 ( i)2.6 (n about)4.2 ( )11.3 (50%)-4.3 ( o)10.5 (f)-6.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( at)4.3 ( i)2.6 (ni)2.6 (t)-6.6 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s)8.9 (y)8.8 (m)-5.9 (pt)-6.6 (om)-6 (s)8.9 ( i)2.6 (n 5%)6.6 ( t)-6.7 (o)10.6 ( 10%)6.5 ( )]TJ -0.013 Tc 0.018 Tw 0 -1.38 Td [(of)-28.5 ( p)-11.3 (at)-17.6 (i)-8.4 (e)]TJ -0.002 Tc 0.007 Tw 3.272 0 Td [(nt)-6.7 (s)8.9 (.)-6.6 ( M)15.8 (any)8.9 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.4 (i)2.6 (t)-6.6 (h adv)8.9 (anc)-2 (ed M)15.8 (T)-10.6 (C)2.6 ( c)-2 (an hav)8.9 (e di)2.6 (ar)-6 (r)-6 (hea,)4.3 ( )]TJ -3.272 -1.37 Td [(C)2.6 (us)-2 (hi)2.6 (ng)-11.2 <92>2.6 (s)-2 ( s)-2 (y)8.8 (ndr)-5.9 (om)-5.9 (e)10.5 (,)4.3 ( or)4.9 ( )11.3 (f)-6.6 (ac)-2 (i)2.7 (al)2.6 ( )11.3 (f)-17.5 (l)2.6 (us)-2 (hi)2.6 (ng,)-6.7 ( bec)-2 (aus)-2 (e)10.6 ( )11.2 (t)4.3 (he t)-6.6 (u)10.5 (m)-5.9 (or)4.9 ( c)-2 (an )11.3 (s)-2 (ec)-1.9 (r)-6 (e)10.5 (t)-6.6 (e )]TJ 0 -1.37 Td [(c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n and s)-2 (o)10.5 (m)-5.9 (et)-6.6 (i)13.5 (m)-6 (e)10.6 (s)-2.1 ( )0.5 (ot)-6.6 (he)10.6 (r)-6 ( ho)10.5 (r)-6 (m)-5.9 (onal)2.6 (l)2.6 (y)8.9 ( ac)-2 (t)-6.6 (i)2.6 (v)8.8 (e pept)-6.7 (i)2.7 (des)-2 ( )11.2 (\()-5.9 (i)2.6 (e,)4.3 ( )]TJ 0 -1.38 Td [(adr)-6 (enoc)-2 (or)4.9 (t)-6.6 (i)2.6 (c)-2 (ot)4.3 (r)-6 (opi)2.7 (c)-2 ( hor)4.9 (m)4.9 (one [)-6.6 (A)2 (C)13.5 (T)-10.6 (H)2.6 (])4.3 (,)-6.6 ( c)-2 (al)2.6 (c)-2 (i)2.7 (t)-6.7 (oni)2.6 (n )11.3 (g)10.5 (ene)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 23.761 0 Td [(r)-6 (el)2.6 (at)-6.6 (ed)10.5 ( pept)-6.6 (i)2.6 (de)]TJ 0 Tc 0 Tw 6.587 0 Td ( )Tj -0.002 Tc 0.007 Tw -30.348 -1.37 Td [([)-6.6 (C)2.6 (G)-6.6 (R)2.6 (P)2 (])4.2 (\))-5.9 (.)4.2 ( )11.3 (T)-10.6 (r)-5.9 (ea)10.5 (t)-6.5 (m)-6 (en)10.6 (t)-6.6 ( w)13.4 (i)2.6 (t)-6.6 (h s)-2 (om)-5.9 (a)10.5 (t)-6.6 (os)8.8 (t)-6.6 (at)-6.6 (i)2.6 (n anal)2.6 (o)10.5 (g)-11.2 (s)8.9 ( \()-6 (e)10.5 (g,)-6.6 ( oc)8.9 (t)-6.6 (r)-6 (eo)10.5 (t)-6.6 (i)2.6 (de,)4.3 ( l)2.6 (anr)-6 (eot)-6.6 (i)2.6 (de\))4.9 ( )]TJ 0 -1.38 Td [(m)-6 (ay)8.9 ( be us)-2 (e)10.6 (f)-6.7 (ul)2.6 ( i)2.6 (n pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (hes)-2 (e s)-2 (y)8.8 (m)-5.9 (p)10.5 (t)-6.6 (om)4.9 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 254.16 194.28 Tm (421)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 265.68 190.32 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(P)2 (at)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ 0.002 Tw -22.217 -1.37 Td [(unr)-6 (es)-2 (e)]TJ 0.007 Tw [(c)-2 (t)-6.6 (abl)2.6 (e)10.5 ( or)5 ( m)-6 (e)10.5 (t)-6.6 (as)8.8 (t)-6.6 (at)4.2 (i)2.7 (c)-2 ( di)2.6 (s)-2 (eas)-2 (e )11.2 (m)-5.9 (ay)8.9 ( hav)8.9 (e ei)2.6 (t)-6.6 (her)-6 ( s)-2 (l)2.6 (ow)13.5 (l)-8.3 (y)8.9 ( pr)-5.9 (ogr)-6 (es)-2 (s)-2 (i)2.6 (v)8.9 (e or)4.9 ( )]TJ 0 -1.38 Td [(r)-6 (api)2.7 (dl)2.6 (y)8.9 ( pr)-5.9 (og)-11.2 (r)-5.9 (e)10.5 (s)-2 (s)-2 (i)2.6 (v)8.9 (e di)2.6 (s)-2 (eas)-2 (e.)]TJ 0 Tc 0 Tw 12.348 0 Td ( )Tj EMC /H2 <>BDC /TT1 1 Tf 0.009 Tc 0.007 Tw -12.348 -2.391 Td [(N)2.7 (o)0.5 (du)0.5 (l)-6.5 (e)10.6 ( )0.6 (E)2.1 (v)10.6 (al)-6.5 (u)0.5 (a)10.6 (t)5.1 (i)-6.5 (on)11.3 ( )0.6 (an)0.5 (d)11.3 ( )0.5 (D)2.8 (i)4.4 (ag)0.5 (nos)10.7 (i)-6.5 (s)10.7 ( )]TJ 0 Tc 0 Tw 16.348 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw -16.348 -1.696 Td [(P)2 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h M)15.8 (T)-10.5 (C)2.6 ( c)-2 (an b)10.5 (e i)2.6 (dent)-6.6 (i)13.5 (f)-17.5 (i)2.6 (ed by)8.8 ( us)-2 (i)2.6 (n)10.5 (g)-11.2 ( pa)10.5 (t)-6.6 (h)10.5 (ol)2.6 (og)-11.2 (i)2.6 (c)-2 ( di)2.6 (a)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)-2 ( o)10.5 (r)-6 ( )0.5 (by)8.9 ( )]TJ 0 -1.38 Td [(pr)-6 (os)-2 (pec)-2 (t)-6.7 (i)2.7 (v)8.8 (e )11.3 (g)-11.3 (enet)-6.6 (i)2.6 (c)8.9 ( s)-2 (c)-2 (r)-6 (e)10.5 (eni)2.6 (ng)-11.2 (.)4.3 ( S)2 (epar)-6 (a)10.5 (t)-6.6 (e pa)10.6 (t)-6.7 (hw)13.5 (ay)-2 (s)-2 ( ar)-6 (e)10.6 ( i)2.6 (n)]TJ [(c)-2 (l)2.6 (uded i)2.6 (n t)-6.6 (h)10.5 (e )]TJ -0.004 Tw 0 -1.37 Td [(al)2.6 (g)-11.3 (or)-6 (i)2.7 (t)-6.7 (h)10.6 (m)-6 ( \()-6 (s)-2 (ee)10.5 ( )]TJ /TT2 1 Tf 0.007 Tw 6.598 0 Td [(C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.7 ( P)1.9 (r)-5.9 (es)-2 (ent)-6.6 (at)-6.6 (i)2.6 (on)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 9.37 0 Td [(i)2.6 (n)10.5 ( t)-6.6 (he)10.5 ( N)2.6 (C)2.6 (C)2.6 (N)2.6 ( G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (or)4.9 ( M)15.7 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( )]TJ -15.967 -1.38 Td [([)4.3 (T)-10.6 (hy)8.9 (r)-5.9 (oi)2.6 (d])-6.6 ( C)2.6 (ar)-5.9 (c)-2 (i)2.6 (no)10.6 (m)-6 (a\))4.9 ( de)10.6 (pendi)2.6 (ng)-11.2 ( on)10.5 ( t)-6.6 (he)10.6 ( )11.2 (m)-5.9 (et)-6.6 (hod)10.5 ( o)10.5 (f)-6.6 ( i)2.6 (dent)-6.6 (i)13.5 (f)-17.5 (i)2.6 (c)-2 (a)10.5 (t)-6.6 (i)2.6 (on.)-6.6 ( )]TJ 0 Tc 0 Tw 28.359 0 Td ( )Tj EMC /H3 <>BDC /TT3 1 Tf 0.016 Tc 0.007 Tw 9.96 -0 0 9.96 405 514.8 Tm [(S)8.3 (p)0.5 (o)0.5 (r)7.4 (a)5.8 (d)0.5 (i)4.8 (c)5.8 ( M)29.7 (T)0.5 (C)]TJ 0 Tc 0 Tw 6.867 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 499.44 Tm [(S)2 (por)-6 (adi)2.6 (c)-2 ( M)15.8 (T)-10.6 (C)2.7 ( i)2.5 (s)-1.9 ( us)-2 (ual)2.6 (l)2.6 (y)8.9 ( s)-2 (us)-2 (pec)-2 (t)-6.6 (ed)10.5 ( a)10.5 (f)-6.6 (t)-6.6 (er)4.9 ( FN)2.6 (A)2 ( o)10.5 (f)-6.6 ( a)10.5 ( s)-2 (ol)2.6 (i)2.6 (t)-6.6 (ar)-5.9 (y)8.8 ( nodul)2.6 (e \()4.9 (s)-2 (ee )]TJ /TT2 1 Tf 0 -1.38 Td [(N)2.6 (odul)2.6 (e E)2 (v)-2 (al)2.7 (uat)-6.6 (i)2.6 (on)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.002 Tc -0.004 Tw 8.37 0 Td [(i)2.6 (n )-10.6 (t)-6.6 (he)10.5 ( N)2.6 (C)2.6 (C)2.6 (N)2.6 ( )-10.6 (G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( f)-17.5 (or)4.9 ( T)-10.5 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d )-10.6 (C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a\))5 (.)-6.7 ( )]TJ 0.007 Tw -8.37 -1.37 Td [(R)2.6 (epor)-6 (t)-6.6 (s)8.9 ( s)-2 (u)10.5 (gg)-11.2 (es)-2 (t)4.2 ( )11.3 (t)-6.6 (hat)4.3 ( ab)10.5 (out)-6.7 ( 3)10.6 (%)-4.3 ( o)10.5 (f)-6.6 ( pa)10.6 (t)-6.7 (i)2.6 (ent)-6.7 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h nodul)2.6 (ar)-5.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d di)2.6 (s)-2 (eas)-2 (e)10.5 ( w)13.5 (i)-8.2 (l)2.5 (l)2.7 ( )]TJ 0 -1.38 Td [(hav)8.9 (e an i)2.6 (nc)-2 (r)-6 (eas)-2 (ed )11.2 (s)-2 (er)-6 (u)10.5 (m)-5.9 ( c)-2 (al)2.6 (c)-2 (i)2.7 (t)-6.7 (oni)2.6 (n)10.5 ( l)2.6 (ev)8.9 (el)2.6 ( )-10.5 (w)13.5 (hen m)-5.9 (eas)-2 (ur)-5.9 (ed)10.6 ( by)8.9 ( a s)-2 (ens)-2 (i)13.5 (t)-6.6 (i)2.6 (v)8.9 (e )]TJ 0 -1.37 Td [(i)2.6 (m)-5.9 (m)-6 (uno)10.5 (m)-5.9 (et)4.3 (r)-6 (i)2.6 (c)-2 ( as)-2 (s)-2 (ay)8.8 (;)4.3 ( 40)10.5 (%)-4.3 ( )0.5 (o)10.5 (f)-6.6 ( )11.2 (t)-6.6 (hes)-2 (e pa)10.6 (t)-6.7 (i)2.6 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (l)2.6 (l)2.6 ( h)-11.2 (av)8.8 (e )-10.5 (M)15.8 (T)-10.6 (C)2.6 ( at)4.3 ( )]TJ 0.002 Tw 0 -1.38 Td [(t)-6.6 (hy)]TJ 1.326 0 Td [(r)-6 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 476.64 427.44 Tm (422)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 1.983 0 Td [(4)-17 (24)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 502.08 423.48 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(H)2.6 (o)-11.2 (w)2.6 (ev)8.8 (er)-6 (,)-6.6 ( r)-5.9 (ou)10.5 (t)-6.6 (i)2.6 (ne )11.3 (m)-5.9 (eas)-2 (ur)-5.9 (e)10.5 (m)-6 (e)10.5 (nt)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (he bas)-2 (al)13.5 ( )]TJ -0.013 Tc 0.013 Tw [(s)-13 (e)-11.3 (r)-17 (um)]TJ 0 Tc 0 Tw 22.391 0 Td ( )Tj -0.002 Tc 0.007 Tw -31.467 -1.37 Td [(c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n c)-2 (onc)-2 (ent)4.3 (r)-6 (at)-6.6 (i)2.6 (on i)13.5 (s)-2 ( not)4.3 ( r)-5.9 (ec)-2.1 (o)10.6 (m)4.9 (m)-6 (ended by)8.9 ( )11.3 (t)4.3 (he N)2.6 (C)2.6 (C)2.6 (N)2.6 ( P)1.9 (anel)2.6 ( )11.3 (f)-17.5 (or)5 ( )]TJ 0 -1.38 Td [(ev)8.8 (al)2.6 (uat)-6.6 (i)2.6 (ng)-11.2 ( a )]TJ [(pa)10.6 (t)-6.6 (i)2.6 (ent)-6.6 ( w)13.5 (i)2.6 (t)-6.6 (h )11.2 (nodul)2.6 (ar)-5.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d di)2.6 (s)-2 (eas)-2 (e)10.5 ( )11.3 (bec)-2 (aus)-2 (e o)10.5 (f)]TJ 0 Tc 0 Tw 26.424 0 Td (:)Tj 0.272 0 Td ( )Tj -0.007 Tc 0.007 Tw 0.283 0 Td [(1)-5.3 (\) )]TJ -0.013 Tc 0.013 Tw 1.163 0 Td [(t)-17.6 (h)-11.3 (e )]TJ -0.002 Tc 0.007 Tw -28.141 -1.37 Td [(ex)8.8 (pens)-2 (e of)-6.6 ( s)-2 (c)8.8 (r)-5.9 (eeni)2.6 (n)10.5 (g)-11.2 ( al)2.6 (l)2.6 ( )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d nodul)2.6 (es)-2 ( )]TJ -0.004 Tw [(and )-10.6 (onl)2.6 (y)8.9 ( f)-17.5 (i)2.6 (ndi)2.6 (n)10.5 (g)]TJ 0 Tc 0 Tw 25.043 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(a)10.5 ( )11.3 (f)-17.5 (ew)13.5 ( c)-1.9 (as)-2 (es)8.9 ( o)10.5 (f)-6.6 ( )]TJ -0.018 Tc 0.018 Tw -25.326 -1.38 Td [(MT)-26.6 (C)]TJ -0.002 Tc 0.007 Tw 2.152 0 Td [(;)-6.6 ( 2\))]TJ 0 Tc 0 Tw 1.446 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(t)-6.6 (he)10.5 ( l)2.6 (ac)8.9 (k)-12.9 ( o)10.6 (f)-6.7 ( c)-1.9 (on)10.5 (f)-6.6 (i)13.5 (r)-6 (m)-5.9 (a)10.5 (t)-6.6 (or)-6 (y)8.9 ( pent)-6.6 (a)10.5 (g)-11.2 (a)10.5 (s)-2 (t)4.3 (r)-6 (i)2.6 (n s)-2 (t)-6.6 (i)13.5 (m)-6 (ul)2.6 (at)-6.6 (i)2.6 (on )11.3 (t)-6.6 (es)-2 (t)-6.7 (i)2.7 (n)10.5 (g)]TJ 0 Tc 0 Tw 24.315 0 Td (;)Tj 0.272 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(and)10.5 ( )]TJ -0.007 Tc 0.007 Tw 1.935 0 Td [(3)-5.3 (\) )]TJ -0.002 Tc -30.685 -1.37 Td [(t)-6.6 (he )11.3 (r)-6 (es)-2 (ul)2.6 (t)-6.6 (i)2.6 (n)10.5 (g)-11.2 ( need)10.5 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( i)2.6 (n )11.3 (s)-2.1 (om)-5.9 (e)10.5 ( pat)-6.6 (i)2.6 (e)10.5 (nt)-6.7 (s)-2 ( w)13.5 (ho ac)-2 (t)-6.6 (ual)2.6 (l)2.6 (y)8.9 ( hav)8.8 (e )]TJ -0.004 Tw 0 -1.38 Td [(beni)2.6 (g)-11.2 (n t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (di)2.6 (s)-2 (eas)-2 (e.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 518.28 336.36 Tm [(425,)-1.8 (4)-17 (26)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 543.36 332.4 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(T)-10.6 (he )]TJ -0.015 Tc 0.015 Tw 2.011 0 Td [(AT)-23.5 (A)-11.1 ( )]TJ -0.005 Tc 0.005 Tw 2.217 0 Td (is)Tj 0 Tc 0 Tw 0.707 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(e)10.5 (q)-11.2 (ui)2.6 (v)8.9 (oc)-2 (al)2.7 ( about)-6.6 ( )11.2 (r)-5.9 (out)-6.6 (i)2.6 (ne)10.5 ( c)-1.9 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n )]TJ 0.002 Tw -18.033 -1.37 Td [(m)-6 (eas)-1.9 (ur)-5.9 (e)10.5 (m)-6 (en)10.5 (t)]TJ 0 Tc 0 Tw 6.098 0 Td (.)Tj 6.96 -0 0 6.96 475.44 321.24 Tm (3)Tj 11.04 -0 0 11.04 479.28 317.28 Tm ( )Tj 0.272 0 Td ( )Tj EMC /H3 <>BDC /TT3 1 Tf 0.016 Tc 0.007 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842 0 R >> stream Q q BT /Xi90 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 842 0 obj 245 endobj %% Original object ID: 11428 0 843 0 obj [ 2655 0 R ] endobj %% Contents for page 93 %% Original object ID: 186 0 844 0 obj << /Length 845 0 R >> stream q endstream endobj 845 0 obj 2 endobj %% Contents for page 93 %% Original object ID: 11429 0 846 0 obj << /Length 847 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 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Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (30)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(A)2 (l)2.6 (l)2.6 ( f)-17.5 (a)10.5 (m)-5.9 (i)2.6 (l)2.6 (i)2.6 (al)2.7 ( f)-17.5 (o)10.5 (r)4.9 (m)-5.9 (s)-2 ( o)10.5 (f)-6.6 ( M)15.8 (T)-10.6 (C)2.6 ( )11.3 (and M)15.8 (E)2 (N)2.6 (2 ar)-6 (e i)2.6 (nher)-5.9 (i)2.6 (t)-6.6 (ed i)13.5 (n an )]TJ 0.002 Tw 0 -1.38 Td [(aut)-6.6 (os)-1.9 (om)-5.9 (al)]TJ 0 Tc 0 Tw 4.598 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(dom)-6 (i)2.7 (nant)4.3 ( f)-17.4 (a)10.5 (s)8.9 (hi)2.6 (on.)-6.6 ( )-10.6 (M)15.8 (ut)-6.7 (at)-6.6 (i)2.6 (ons)-2 ( )-10.6 (i)2.6 (n t)-6.6 (he )]TJ /TT2 1 Tf -0.016 Tc 0.016 Tw 15.457 0 Td [(RE)-12.1 (T)]TJ /TT0 1 Tf 0 Tc 0 Tw 1.978 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(pr)-6 (ot)-6.6 (o)]TJ 0 Tc 0 Tw 2.272 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(onc)-2 (o)10.5 (g)-11.2 (ene)10.6 ( ar)-6 (e)10.6 ( )]TJ -25.261 -1.37 Td [(f)-6.6 (ound i)2.6 (n a)10.5 (t)-6.6 ( l)2.6 (eas)8.9 (t)-6.6 ( 95)10.5 (%)-4.3 ( o)10.5 (f)-6.6 ( )11.3 (k)-12.9 (i)2.6 (ndr)-5.9 (eds)8.9 ( w)13.4 (i)2.7 (t)-6.6 (h M)15.8 (E)1.9 (N)2.6 (2A)2 ( an)-11.2 (d 88%)6.6 ( o)10.5 (f)-6.6 ( )11.3 (f)-17.5 (a)10.5 (m)-5.9 (i)2.6 (l)2.6 (i)2.6 (al)2.6 ( )]TJ -0.018 Tc 0.018 Tw 0 -1.38 Td [(MT)-26.6 (C)-13.4 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 50.4 472.32 Tm [(415)-16.9 (,)-1.9 (41)-17 (6,)-19.1 (428)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 89.16 468.36 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(T)-10.6 (he )]TJ /TT2 1 Tf -0.005 Tc 0.005 Tw 2.011 0 Td [(RE)-1 (T)]TJ /TT0 1 Tf 0 Tc 0 Tw 1.989 0 Td ( )Tj -0.013 Tc 0.013 Tw 0.283 0 Td [(pr)-16.9 (o)-11.4 (t)-17.6 (o)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 2.598 0 Td [(onc)-2 (o)10.5 (g)-11.2 (ene )-10.6 (c)-2 (od)10.6 (es)-2 ( f)-6.7 (or)4.9 ( a)]TJ 0 Tc 0 Tw ( )Tj -0.005 Tc 0.005 Tw 9.859 0 Td [(c)-5 (e)-3.4 (ll )]TJ -0.002 Tc 0.002 Tw -22.967 -1.37 Td [(m)-6 (em)-6 (b)10.6 (r)-6 (ane)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 5.109 0 Td [(as)8.8 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (ed)10.5 ( )-10.6 (t)-6.6 (y)8.9 (r)-6 (os)-2 (i)2.6 (ne k)-12.8 (i)2.6 (nas)-2 (e r)-5.9 (ec)-2 (ep)10.5 (t)-6.6 (or)4.9 ( f)-17.5 (o)10.6 (r)-6 ( )-10.6 (a)10.5 ( g)-11.2 (l)2.6 (i)2.6 (al)2.6 (,)-6.6 ( )-10.6 (c)-2 (el)2.6 (l)2.6 ( )-10.6 (l)2.6 (i)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 24.141 0 Td [(der)-6 (i)2.7 (v)8.8 (ed )]TJ -0.004 Tw -29.25 -1.38 Td [(neur)-6 (ot)4.2 (r)-5.9 (ophi)2.6 (c)-2 ( f)-17.5 (a)10.6 (c)-2 (t)-6.7 (o)10.6 (r)-6 (.)4.3 ( )]TJ 0.007 Tw 8.87 0 Td [(M)15.8 (ut)-6.6 (at)-6.6 (i)2.6 (ons)-2 ( as)-2 (s)-2 (oc)-2 (i)2.6 (a)10.5 (t)-6.6 (ed w)13.5 (i)2.6 (t)-6.6 (h M)15.7 (E)-8.9 (N)2.6 (2A)1.9 ( and )11.3 (f)-17.5 (a)10.5 (m)-5.9 (i)2.6 (l)2.6 (i)2.6 (al)2.7 ( M)15.8 (T)-10.5 (C)2.6 ( )]TJ -8.87 -1.37 Td [(hav)8.9 (e been pr)-6 (i)2.6 (m)-5.9 (a)10.5 (r)-5.9 (i)2.6 (l)2.6 (y)8.9 ( i)2.7 (den)-11.2 (t)-6.7 (i)13.5 (f)-17.5 (i)2.7 (ed i)2.7 (n s)-2 (ev)8.8 (er)-6 (al)2.6 ( c)-2 (odons)8.9 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.7 (he )0.5 (c)-2.1 (y)8.9 (s)-2 (t)-6.6 (ei)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.005 Tc 0.005 Tw 28.033 0 Td [(r)-9 (ic)-5 (h)-3.3 ( )]TJ -0.002 Tc 0.007 Tw -28.033 -1.38 Td [(ex)8.8 (t)-6.6 (r)-5.9 (ac)-2 (el)2.6 (l)2.6 (ul)2.7 (ar)-5.9 ( dom)-5.9 (ai)2.6 (ns)-2 ( o)10.5 (f)-6.6 ( )11.3 (ex)8.8 (ons)-2 ( 10,)]TJ 0 Tc 0 Tw 15.13 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(11)10.5 (,)-6.6 ( and)10.5 ( 13;)4.3 ( M)4.9 (E)1.9 (N)2.6 (2B)1.9 ( and s)-2 (om)-6 (e)10.5 ( )11.3 (f)-6.6 (am)-5.9 (i)2.6 (l)2.6 (i)2.6 (al)2.6 ( )]TJ -15.413 -1.37 Td [(M)15.8 (T)-10.6 (C)2.6 ( m)-5.9 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (ons)-1.9 ( )]TJ [(a)10.6 (r)-6 (e )11.2 (f)-6.6 (oun)10.6 (d w)13.5 (i)2.6 (t)-6.6 (hi)2.6 (n t)-6.6 (he i)2.6 (nt)-6.7 (r)-5.9 (a)10.5 (c)-2 (el)2.6 (l)2.6 (ul)2.6 (ar)-5.9 ( )11.2 (ex)8.8 (ons)-2 ( 14)]TJ 0 Tc 0 Tw ( )Tj -0.013 Tc 0.013 Tw 25.696 0 Td [(t)-17.6 (o )]TJ -0.002 Tc 0.002 Tw 1.109 0 Td (16.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 334.8 396.48 Tm [(413,)-1.8 (41)-17 (4)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 359.88 392.52 Tm ( )Tj -0.004 Tc 0.004 Tw -30.467 -1.38 Td [(So)-2.4 (m)]TJ -0.005 Tc 0.005 Tw 2.054 0 Td [(a)-3.3 (t)-9.7 (ic)]TJ 0 Tc 0 Tw 1.554 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(m)-6 (u)10.6 (t)-6.6 (at)-6.6 (i)2.6 (ons)-2 ( i)2.6 (n)10.5 ( ex)8.9 (ons)-2 ( 11,)4.3 ( 13,)4.3 ( and 1)10.5 (6 hav)8.9 (e )11.2 (al)2.6 (s)-2 (o been )11.2 (f)-17.5 (o)10.6 (und i)2.6 (n a)10.5 (t)-6.6 ( )]TJ -3.88 -1.37 Td [(l)2.6 (eas)-2 (t)-6.6 ( 25%)6.6 ( o)10.5 (f)-6.6 ( s)-2 (po)10.6 (r)-6 (adi)2.6 (c)-2 ( M)15.8 (T)-10.6 (C)2.6 ( )11.3 (t)-6.6 (u)10.5 (m)-5.9 (or)-5.9 (s)]TJ 0 Tc 0 Tw 15.293 0 Td <97>Tj -0.002 Tc 0.007 Tw 0.989 0 Td [(par)4.9 (t)-6.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 (l)2.6 (y)8.9 ( t)-6.6 (he c)-2 (odon 918)10.5 ( )11.3 (m)-6 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (on )]TJ -0.004 Tw -16.283 -1.38 Td [(t)-6.6 (hat)4.3 ( )-10.6 (ac)-2 (t)-6.6 (i)2.6 (v)8.9 (at)-6.6 (es)-2 ( t)-6.7 (he t)-6.6 (y)8.9 (r)-6 (os)-2 (i)2.6 (ne k)-12.9 (i)2.6 (nas)-2 (e f)-6.6 (unc)-2 (t)-6.6 (i)2.6 (on)10.5 ( )-10.6 (o)10.5 (f)-6.6 ( )-10.6 (t)-6.6 (he)10.6 ( )-10.6 (r)4.9 (ec)-2 (ept)-6.6 (or)]TJ 0 Tc 0 Tw 24.935 0 Td <97>Tj -0.002 Tc 0.007 Tw [(and a)10.5 (r)-6 (e )]TJ -24.935 -1.37 Td [(as)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (ed w)13.5 (i)2.6 (t)-6.6 (h poor)-6 (e)10.5 (r)-5.9 ( p)10.5 (r)-6 (o)10.6 (g)-11.3 (nos)-2 (i)2.6 (s)]TJ 0 Tc 0 Tw 14.576 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(o)10.5 (f)-6.6 ( t)-6.6 (he )-10.6 (pa)10.5 (t)-6.6 (i)2.7 (ent)-6.6 (.)4.2 ( )]TJ 0 Tc 0 Tw ( )Tj EMC /P <>BDC -0.004 Tc 0.004 Tw -14.859 -2.38 Td [(Ab)-2.4 (o)]TJ -0.002 Tc 0.007 Tw 1.772 0 Td [(ut)-6.6 ( 6%)6.6 ( o)10.5 (f)-6.6 ( pa)10.5 (t)-6.6 (i)2.7 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-17.5 (h c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 (l)-8.2 (y)8.8 ( s)-2 (por)-5.9 (adi)2.6 (c)-2 ( M)15.8 (T)-10.6 (C)2.6 ( c)-2 (ar)4.9 (r)-6 (y)8.9 ( a )11.3 (g)-11.2 (er)4.9 (m)-6 (l)2.6 (i)2.6 (ne )]TJ -1.772 -1.37 Td [(m)-6 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (on i)2.6 (n )]TJ /TT2 1 Tf -0.005 Tc 0.005 Tw [(RE)-1.1 (T)]TJ /TT0 1 Tf -0.002 Tc 0.007 Tw 7.152 0 Td [(,)4.3 ( l)2.6 (eadi)2.6 (ng t)-6.6 (o)10.5 ( i)2.7 (dent)-6.6 (i)13.5 (f)-17.5 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (on)10.6 ( o)10.5 (f)-6.6 ( new)13.4 ( k)-1.9 (i)2.5 (ndr)-6 (eds)-2 ( w)13.5 (i)2.6 (t)-6.6 (h m)-5.9 (ul)2.6 (t)-6.6 (i)2.6 (pl)2.6 (e )]TJ -7.152 -1.38 Td [(\()-6 (pr)-6 (ev)8.9 (i)2.6 (ous)-2 (l)2.6 (y)8.9 ( undi)2.6 (ag)-11.2 (nos)-2 (ed\))-6 ( a)10.6 (f)-6.7 (f)-6.6 (ec)8.8 (t)-6.5 (ed i)2.7 (ndi)2.6 (v)8.8 (i)2.7 (dual)2.6 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 246.12 279.12 Tm [(42)-17 (9,)-1.9 (4)-16.9 (30)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 271.32 275.16 Tm ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(G)-6.6 (enet)-6.6 (i)2.7 (c)-2 ( t)-6.6 (es)-2 (t)-6.6 (i)2.6 (n)10.5 (g f)-17.5 (o)10.6 (r)-6 ( )]TJ /TT2 1 Tf -0.005 Tc 0.005 Tw -22.728 -1.37 Td [(RE)-1 (T)]TJ /TT0 1 Tf 0 Tc 0 Tw 1.989 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(pr)-6 (ot)-6.6 (o)]TJ 0 Tc 0 Tw 2.272 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(onc)-2 (o)10.5 (g)-11.2 (ene)10.5 ( m)-5.9 (u)10.5 (t)-6.6 (at)-6.6 (i)2.7 (ons)-2 ( i)2.6 (s)8.8 ( r)-5.9 (ec)-2 (o)10.6 (m)4.9 (m)-6 (ended )11.2 (f)-6.6 (or)4.9 ( al)2.7 (l)2.6 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h new)13.5 (l)-8.3 (y)-2 ( )]TJ 0.002 Tw -4.88 -1.37 Td (di)Tj 0.007 Tw 0.772 0 Td [(ag)-11.3 (nos)-2 (ed )11.2 (c)-2 (l)2.6 (i)2.7 (ni)2.6 (c)-2 (al)2.6 (l)-8.3 (y)8.9 ( appar)-6 (ent)4.3 ( s)-2 (por)-6 (adi)2.6 (c)8.8 ( M)15.8 (T)-10.5 (C)2.6 (,)-6.6 ( and)10.5 ( )11.2 (f)-6.6 (or)-6 ( s)-2 (c)8.9 (r)-6 (eeni)2.6 (n)10.5 (g)-11.2 ( c)-2 (hi)2.6 (l)2.6 (dr)-5.9 (en)10.6 ( )]TJ -0.772 -1.38 Td [(and adul)2.6 (t)-6.6 (s)-2 ( i)2.6 (n)10.6 ( )11.2 (k)-12.9 (now)13.5 (n k)-12.9 (i)2.6 (nd)10.5 (r)-6 (eds)-2 ( w)13.4 (i)2.6 (t)-6.6 (h i)2.6 (nher)-5.9 (i)2.6 (t)-6.6 (ed)10.6 ( )11.2 (f)-17.4 (o)10.5 (r)-6 (m)-5.9 (s)8.8 ( o)10.6 (f)-6.6 ( M)15.7 (T)-10.5 (C)2.6 (;)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 306.12 233.64 Tm (431)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 317.64 229.68 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(g)-11.2 (enet)-6.6 (i)2.7 (c)8.8 ( )]TJ 0.007 Tw -26.924 -1.37 Td [(c)-2 (ouns)-2 (el)2.6 (i)2.6 (ng)-11.2 ( s)-2 (houl)2.6 (d)10.6 ( be c)-2 (o)10.5 (ns)-2 (i)2.6 (der)-6 (ed.)-6.6 ( M)15.8 (T)-10.6 (C)2.6 ( )11.3 (c)-2 (an i)2.6 (nv)8.8 (ol)2.6 (v)8.9 (e di)2.6 (f)-6.6 (f)-17.5 (i)2.6 (c)-2 (ul)2.6 (t)4.2 ( et)-6.6 (hi)2.6 (c)-2 (al)2.6 ( )]TJ 0 -1.38 Td [(dec)-2 (i)2.6 (s)-2 (i)2.6 (ons)-2 ( )11.3 (f)-17.5 (or)4.9 ( c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (i)2.6 (ans)-2 ( i)13.5 (f)-17.5 ( )11.3 (par)-6 (ent)-6.6 (s)8.9 ( or)4.9 ( )11.3 (g)-11.2 (uar)-6 (di)2.6 (ans)8.9 ( r)-6 (e)10.5 (f)4.3 (us)-2 (e s)-2 (c)8.9 (r)-6 (eeni)2.6 (ng and/)-6.7 (o)10.6 (r)-6 ( )]TJ 0 -1.37 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( )11.3 (f)-6.6 (or)5 ( c)-2 (hi)2.6 (l)2.6 (dr)-6 (en w)13.5 (i)2.6 (t)-6.6 (h pos)-2 (s)-2 (i)2.6 (bl)2.6 (e M)15.8 (T)-10.6 (C)2.6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 223.56 188.16 Tm (432)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 235.08 184.2 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.013 Tc 0.007 Tw -19.446 -2.38 Td [(T)-21.6 (h)-11.3 (e g)]TJ -0.002 Tc 2.554 0 Td [(ener)-6 (al)2.6 (l)2.6 (y)8.8 ( ac)-2 (c)-2 (ept)-6.6 (ed)10.6 ( )11.2 (pr)-6 (eoper)-5.9 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e w)13.5 (or)-6 (k)-12.9 (up i)2.6 (nc)-2 (l)2.6 (ude)]TJ 0 Tc 0 Tw (s)Tj ( )Tj -0.002 Tc 0.007 Tw 21.326 0 Td [(m)-6 (ea)10.5 (s)-2 (ur)-6 (e)10.5 (m)-5.9 (ent)4.2 ( o)10.6 (f)-6.6 ( )]TJ 0.002 Tw -23.88 -1.37 Td [(s)-2 (er)-6 (um)5 ( )]TJ -0.004 Tw 3.054 0 Td [(m)-6 (a)10.6 (r)4.9 (k)-12.9 (e)10.5 (r)-5.9 (s)-2 ( \()-5.9 (bas)-2 (al)2.7 ( )]TJ -0.013 Tc 0.013 Tw 6.87 0 Td [(s)-13 (er)-16.9 (u)-11.4 (m)-6.1 ( )]TJ -0.002 Tc 0.007 Tw 3.043 0 Td [(c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n and)10.6 ( s)-2 (er)-5.9 (u)10.5 (m)-6 ( c)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (noem)-6 (b)10.5 (r)-5.9 (y)8.9 (oni)2.7 (c)-2 ( )]TJ -12.967 -1.38 Td [(ant)-6.6 (i)2.6 (g)-11.2 (en)10.6 ( [)-6.6 (C)2.6 (E)1.9 (A)2 (])4.2 (\))-5.9 ( and)10.5 ( s)-2 (c)8.9 (r)-6 (e)10.6 (eni)2.6 (ng)-11.2 ( )]TJ -0.013 Tc 0.013 Tw [(of)-17.6 ( )]TJ -0.002 Tc 0.007 Tw 14.413 0 Td [(pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h g)-11.3 (e)10.6 (r)4.9 (m)-6 (l)2.6 (i)2.7 (ne )]TJ /TT2 1 Tf -0.005 Tc 0.005 Tw [(RE)-1.1 (T)-2.7 ( )]TJ /TT0 1 Tf -0.002 Tc 0.002 Tw -14.413 -1.37 Td [(pr)-6 (ot)-6.6 (o)]TJ 0 Tc 0 Tw 2.272 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(onc)-2 (o)10.5 (g)-11.2 (ene m)-5.9 (u)]TJ 0.007 Tw 6.033 0 Td [(t)-6.6 (at)-6.6 (i)2.6 (on)10.5 (s)-2 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( pheoc)-2 (h)10.5 (r)-5.9 (o)10.5 (m)-6 (oc)-2 (y)8.9 (t)-6.7 (om)-6 (a)10.6 ( \()-6 (M)15.8 (E)2 (N)2.6 (2A)2 ( and )]TJ -0.018 Tc 0.018 Tw [(ME)-14.1 (N)]TJ -0.004 Tc 0.004 Tw 21.859 0 Td [(2)-13.2 (B\))-7.9 ( )]TJ -0.002 Tc 0.007 Tw -30.5 -1.38 Td [(and hy)8.9 (per)-6 (par)-5.9 (at)-6.6 (hy)8.9 (r)-6 (oi)2.6 (di)2.6 (s)-2 (m)4.9 ( \()-5.9 (M)15.8 (E)1.9 (N)2.6 (2A)1.9 (\))-5.9 (.)-6.6 ( B)1.9 (e)10.6 (f)-17.5 (o)10.5 (r)-6 (e )]TJ -0.007 Tc [(s)-7 (u)5.5 (rg)-16.2 (e)-5.3 (ry)]TJ 0 Tc 0 Tw 22.424 0 Td ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(f)-20.5 (o)7.5 (r)-8.9 ( M)12.7 (T)-13.5 (C,)1.2 ( it)-9.6 ( is)5.8 ( im)-8.9 (p)-3.4 (o)7.5 (r)-8.9 (t)-9.6 (a)-3.4 (n)7.5 (t)1.3 ( )]TJ -0.002 Tc -0.004 Tw -22.707 -1.37 Td [(t)-6.6 (o )-10.7 (di)2.6 (a)10.5 (g)-11.2 (nos)-2 (e and )]TJ 0.002 Tw 7.38 0 Td [(add)10.5 (r)-5.9 (es)-2 (s)]TJ 0 Tc 0 Tw 3.533 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(c)-2 (oex)8.9 (i)2.6 (s)-2 (t)-6.6 (i)2.6 (ng)-11.2 ( pheo)10.5 (c)-2 (hr)-6 (o)10.5 (m)-5.9 (oc)8.9 (y)8.9 (t)-6.6 (om)-5.9 (a)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 13.739 0 Td [(t)-6.6 (o)10.5 ( av)8.8 (oi)2.6 (d )]TJ -24.935 -1.38 Td [(hy)8.8 (per)-5.9 (t)-6.6 (ens)-2 (i)2.6 (v)8.9 (e c)-2 (r)-5.9 (i)2.6 (s)-2 (i)2.6 (s)-2 ( dur)-6 (i)2.6 (n)10.6 (g s)-2 (ur)5 (g)-11.2 (e)10.5 (r)-6 (y)]TJ 0 Tc 0 Tw 14.837 0 Td ( )Tj -0.013 Tc 0.013 Tw 0.283 0 Td [(\()-17 (s)-13 (e)-11.3 (e )]TJ /TT2 1 Tf -0.002 Tc 0.002 Tw -15.12 -1.37 Td [(P)2 (heoc)-2 (hr)-6 (om)-6 (oc)8.8 (y)-2 (t)-6.6 (o)10.6 (m)-6 (a/)-6.7 (P)2 (a)10.5 (r)4.9 (agangl)2.6 (i)2.6 (om)-6 (a)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.005 Tc 0.01 Tw 16.12 0 Td [(in)-3.3 ( t)]TJ 1.337 0 Td [(h)-3.3 (e)7.5 ( NCCN G)-9.6 (u)-3.3 (id)-3.4 (e)-3.3 (lin)-3.4 (e)-3.3 (s)-5 ( )11.2 (f)-20.5 (o)7.6 (r)-9 ( )]TJ -0.002 Tc 0.002 Tw 17.098 41.87 Td [(N)2.6 (eur)-5.9 (oendoc)-2 (r)-5.9 (i)2.6 (ne )]TJ -0.013 Tc 0.013 Tw 7.37 0 Td [(T)-21.6 (um)-17 (o)-11.3 (r)-6.1 (s)]TJ -0.002 Tc 0.007 Tw 3.38 0 Td [(,)4.3 ( av)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.005 Tc 0.005 Tw [(www)10.4 (.)-9.6 (NCC)-11.2 (N)-11.3 (.)-9.6 (o)-3.4 (r)1.9 (g)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 666.12 513.96 Tm (\).)Tj 0 Tc 0 Tw 0.609 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 588.48 511.92 77.639 0.84 re f BT /CS1 cs 0 scn -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 405 498.72 Tm [(P)2 (heoc)-2 (hr)-6 (om)-6 (oc)-2 (y)8.8 (t)-6.6 (o)10.6 (m)-6 (a)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 9.152 0 Td [(c)-2 (an)10.5 ( )11.2 (be r)-5.9 (e)10.5 (m)-6 (ov)8.9 (ed us)-2 (i)2.6 (ng l)2.7 (apar)-5.9 (o)10.5 (s)-2 (c)-2 (opi)2.6 (c)]TJ 0 Tc 0 Tw 15.663 0 Td ( )Tj -0.002 Tc 0.002 Tw -24.815 -1.37 Td [(adr)-6 (enal)2.6 (ec)-2 (t)-6.6 (o)10.5 (m)-6 (y)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 480.24 487.56 Tm [(413,)-19.1 (41)-17 (4,)-1.8 (4)-17 (33)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 519 483.6 Tm ( )Tj -0.002 Tc 0.007 Tw 0.293 0 Td [(P)2 (r)-6 (eoper)-5.9 (at)-6.6 (i)2.6 (v)8.9 (e t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d and)10.5 ( nec)8.9 (k)-12.9 ( ul)13.5 (t)-6.6 (r)-6 (as)-2 (ound)10.6 ( )]TJ -10.62 -1.38 Td [(\()-6 (i)2.7 (nc)-2 (l)2.6 (udi)2.6 (ng)-11.2 ( c)-2 (en)10.5 (t)-6.6 (r)-5.9 (al)13.5 ( and l)2.6 (at)4.3 (er)-5.9 (al)2.6 ( )0.5 (nec)8.9 (k)-2 ( c)-2 (om)-6 (pa)10.5 (r)-6 (t)4.3 (m)-5.9 (en)10.5 (t)-6.6 (s)-2 (\))4.9 ( i)2.6 (s)]TJ 0 Tc 0 Tw 22.772 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(r)-6 (e)10.6 (c)-2 (om)4.9 (m)-5.9 (ended.)4.3 ( )]TJ -23.054 -1.37 Td [(C)2.6 (ont)-6.6 (r)-6 (as)8.9 (t)]TJ 0 Tc 0 Tw 3.772 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(enhanc)-2 (ed)10.6 ( C)13.5 (T)-10.5 ( o)10.5 (f)-6.6 ( c)-2 (hes)8.8 (t)-6.6 ( a)10.5 (nd l)2.6 (i)2.6 (v)8.9 (er)-6 ( M)15.8 (R)2.6 (I)-6.6 ( or)-6 ( 3)]TJ 0 Tc 0 Tw 17.88 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(phas)-2 (e C)13.5 (T o)10.5 (f)-6.6 ( l)2.6 (i)2.6 (v)8.9 (er)-5.9 ( c)-2 (an )]TJ -22.326 -1.38 Td [(be c)-2 (ons)-2 (i)2.6 (der)-5.9 (ed)10.6 (,)-6.7 ( al)2.6 (t)-6.6 (hou)10.5 (g)-11.2 (h)10.5 ( )11.3 (di)2.6 (s)-2 (t)-6.7 (ant)-6.6 ( )11.3 (m)-5.9 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (as)-2 (i)2.6 (s)8.8 ( )0.5 (does)8.9 ( )11.3 (not)-6.6 ( c)-2 (on)10.5 (t)-6.6 (r)-5.9 (ai)2.6 (ndi)2.6 (c)-2 (at)-6.6 (e)10.5 ( )]TJ 0.002 Tw 0 -1.37 Td [(s)-2 (ur)4.9 (g)-11.3 (er)-5.9 (y)8.8 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 444.84 426.84 Tm [(413,)-1.8 (4)-17 (14)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 469.92 422.88 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(Li)-8.3 (v)8.9 (er)-5.9 ( i)2.6 (m)-6 (a)10.5 (g)-11.2 (i)2.6 (ng i)2.6 (s)-1.9 ( r)-5.9 (a)10.5 (r)-6 (el)2.6 (y)8.9 ( needed i)13.5 (f)-6.6 ( t)-6.6 (he)10.5 ( c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n i)2.6 (s)-2 ( l)2.6 (es)-2 (s)8.9 ( t)-6.6 (han)10.5 ( )]TJ -6.163 -1.38 Td [(400 p)10.5 (g)-11.2 (/)4.2 (m)-5.9 (L.)4.3 ( E)1.9 (v)8.9 (al)2.6 (uat)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( v)8.9 (oc)-2 (al)2.6 ( c)-2 (or)-5.9 (d )11.3 (m)-6 (obi)2.6 (l)2.6 (i)2.6 (t)-6.6 (y)8.8 ( c)-2 (an )11.3 (al)2.6 (s)-2 (o be c)-2 (ons)-2 (i)2.7 (der)-6 (ed)10.5 ( )11.2 (f)-6.6 (or)4.9 ( )]TJ 0 -1.37 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h abnor)4.9 (m)-6 (al)2.6 ( v)8.8 (oi)2.6 (c)-2 (e,)-6.6 ( )0.5 (s)-2 (u)10.5 (r)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( hi)2.6 (s)-2 (t)-6.6 (or)-5.9 (y)8.9 ( i)2.6 (nv)8.9 (ol)2.7 (v)-2 (i)2.6 (ng)-11.2 ( )11.3 (t)-6.6 (he )11.2 (r)-5.9 (ec)-2 (u)]TJ 0.002 Tw [(r)4.9 (r)-6 (ent)4.2 ( )]TJ 0.007 Tw 0 -1.38 Td [(l)2.6 (ar)-6 (y)8.9 (ng)-11.2 (eal)2.6 ( or)4.9 ( v)8.9 (ag)-11.2 (us)-2 ( ne)10.5 (r)-5.9 (v)8.9 (es)-2 (,)-6.6 ( i)2.6 (nv)8.8 (as)-2 (i)2.6 (v)8.9 (e di)2.6 (s)-2 (eas)-2 (e,)-6.6 ( or)4.9 ( b)10.5 (ul)2.6 (k)-12.9 (y)8.9 ( di)2.6 (s)-2 (eas)-2 (e o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (he )]TJ 0 -1.37 Td [(c)-2 (ent)-6.6 (r)-6 (al)2.6 ( ne)10.5 (c)8.9 (k)-12.9 (.)4.2 ( )]TJ 0 Tc 0 Tw 5.924 0 Td ( )Tj ET EMC BT /H2 <>BDC /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 405 335.64 Tm [(S)-8.9 (t)-16.8 (a)-11.3 (gi)-17.5 (n)-10.6 (g )]TJ 0 Tc 0 Tw 4 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw -4 -1.696 Td [(A)2 (s)-2 ( pr)-5.9 (ev)8.9 (i)2.6 (ous)-2 (l)2.6 (y)8.9 ( m)-6 (ent)-6.6 (i)2.6 (oned,)-6.6 ( )11.3 (t)]TJ 0.002 Tw 11.696 0 Td (he)Tj 0 Tc 0 Tw ( )Tj -0.002 Tc -0.004 Tw 1.391 0 Td [(N)2.6 (C)2.6 (C)2.6 (N)2.6 ( G)-6.6 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( f)-6.7 (or)-5.9 ( T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (C)2.6 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (a )-10.6 (do)10.5 ( )]TJ 0.007 Tw -13.087 -1.37 Td [(not)-6.6 ( us)-2 (e)10.6 ( )11.2 (T)-10.5 (N)2.6 (M)15.8 ( s)-2 (t)-6.6 (a)10.5 (g)-11.2 (es)-2 ( )11.3 (t)-6.6 (o )11.3 (gui)2.6 (de t)-6.6 (her)-5.9 (apy)8.8 (.)-6.6 ( )11.3 (I)-6.6 (ns)8.9 (t)-6.6 (ead,)4.2 ( m)4.9 (any)8.9 ( c)-2 (har)-5.9 (ac)-2 (t)-6.6 (e)10.5 (r)-5.9 (i)2.6 (s)-2 (t)-6.6 (i)2.6 (c)-2 (s)-2 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (he)10.5 ( )]TJ 0 -1.38 Td [(t)-6.6 (um)-5.9 (o)10.5 (r)-5.9 ( and)10.5 ( pat)]TJ 6.163 0 Td [(i)2.6 (en)10.5 (t)-6.6 ( pl)2.6 (ay)8.9 ( i)2.6 (m)-6 (por)4.9 (t)-6.6 (ant)4.3 ( r)-6 (ol)2.6 (es)8.9 ( i)2.6 (n t)-6.6 (hes)8.9 (e )11.3 (N)2.6 (C)2.6 (C)2.6 (N)2.6 ( G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 (.)-6.6 ( M)15.8 (an)-11.2 (y)-2 ( )]TJ -6.163 -1.37 Td [(s)-2 (pec)-2 (i)2.6 (al)2.6 (i)2.6 (s)-2 (t)-6.6 (s)-2 ( i)2.6 (n t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (an)10.5 (c)-2 (er)-5.9 ( al)2.6 (s)-2 (o)10.6 ( )11.2 (f)-17.4 (ol)2.6 (l)2.6 (ow)13.5 ( t)-6.6 (hi)2.6 (s)-2 ( par)-5.9 (ad)10.5 (i)2.6 (g)-11.2 (m)5 (.)-6.7 ( )11.3 (T)-10.6 (he)10.5 ( )11.3 (T)-10.6 (N)2.6 (M)15.8 ( c)-2 (r)-5.9 (i)2.6 (t)-6.6 (er)-5.9 (i)2.6 (a )11.3 (f)-6.6 (or)5 ( )]TJ 0 -1.38 Td [(c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (opat)-6.6 (hol)2.7 (og)-11.2 (i)2.6 (c)-2 ( t)-6.6 (u)10.5 (m)-5.9 (o)10.5 (r)-6 ( s)8.9 (t)-6.6 (a)10.5 (g)-11.2 (i)2.6 (ng ar)-6 (e)10.5 ( bas)-2 (ed)10.5 ( on )11.3 (t)-6.6 (um)4.9 (or)-6 ( s)-2 (i)2.6 (z)8.9 (e,)-6.7 ( )11.3 (t)-6.6 (he p)10.5 (r)-5.9 (es)-2 (enc)-2 (e)10.6 ( or)4.9 ( )]TJ 0 -1.37 Td [(abs)-2 (enc)-2 (e o)10.5 (f)-6.6 ( ex)8.9 (t)-6.6 (r)-6 (a)10.6 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (dal)2.6 ( i)2.6 (nv)8.8 (as)-2 (i)2.6 (on,)-6.6 ( l)2.6 (oc)-1.9 (or)-5.9 (eg)-11.2 (i)2.6 (onal)]TJ 0 Tc 0 Tw 21 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(n)10.5 (odal)2.6 ( m)-6 (et)-6.6 (a)10.5 (s)-2 (t)-6.6 (as)-1.9 (es)8.9 (,)4.2 ( and )]TJ -0.004 Tw -21.283 -1.38 Td [(di)2.6 (s)-2 (t)-6.6 (ant)-6.6 ( m)-5.9 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (as)8.9 (es)-2 ( \()-6 (s)-2 (ee )]TJ 0.007 Tw [(T)-10.6 (abl)2.6 (e 1)]TJ 0 Tc 0 Tw 14.13 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (n t)-6.6 (he)10.5 ( N)2.6 (C)2.7 (C)2.6 (N)2.6 ( G)-6.6 (ui)13.5 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (or)4.9 ( )11.3 (T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0.002 Tw -14.413 -1.37 Td [(C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)]TJ -0.007 Tc 0.007 Tw (\).)Tj 0 Tc 0 Tw 6.96 -0 0 6.96 465 214.68 Tm (9)Tj 11.04 -0 0 11.04 468.84 210.72 Tm ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(T)-10.6 (he 8)]TJ 0.002 Tw 6.96 -0 0 6.96 500.16 214.68 Tm (th)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 505.92 210.72 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(edi)2.6 (t)4.3 (i)2.6 (on o)10.5 (f)-17.5 ( )11.3 (t)-6.6 (he A)2 (J)-2 (C)2.6 (C)2.6 ( C)2.6 (anc)8.9 (er)4.9 ( )11.3 (S)2 (t)-6.7 (ag)-11.2 (i)2.6 (n)10.5 (g M)15.7 (anual)2.6 ( )]TJ -9.424 -1.38 Td [(s)-2 (epar)-6 (at)-6.6 (ed)10.5 ( M)15.8 (T)-10.6 (C)2.7 ( i)2.6 (nt)-6.6 (o i)13.5 (t)-6.6 (s)-2 ( o)10.6 (w)13.4 (n s)-2 (t)-6.6 (and)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 15.185 0 Td [(al)2.6 (one c)-2 (hap)10.5 (t)-6.6 (er)4.9 (.)]TJ 0 Tc 0 Tw 6.96 -0 0 6.96 642.36 199.44 Tm (9)Tj 11.04 -0 0 11.04 646.2 195.48 Tm ( )Tj 0.283 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(M)15.8 (any)8.9 ( of)-17.5 ( )11.3 (t)-6.6 (he)10.6 ( s)-2 (t)-6.6 (udi)2.6 (es)8.9 ( )]TJ -22.413 -1.37 Td [(c)-2 (i)2.6 (t)-6.6 (ed i)2.6 (n )11.2 (t)-6.6 (hi)2.6 (s)-2 ( D)2.6 (i)2.6 (s)-2 (c)-2 (us)-2 (s)-2 (i)2.6 (on )11.2 (r)5 (epor)-5.9 (t)-6.6 (i)2.6 (n)10.5 (g)-11.2 ( on)10.6 ( A)2 (J)-2 (C)2.6 (C)]TJ 0 Tc 0 Tw 18.554 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(T)-10.6 (N)2.6 (M)15.8 ( s)-2 (t)-6.6 (a)10.5 (g)-11.2 (i)2.6 (ng hav)8.9 (e r)-6 (e)10.5 (f)-6.6 (er)]TJ -0.004 Tw 10.413 0 Td [(r)-6 (ed t)-6.6 (o )]TJ 0.007 Tw -29.293 -1.38 Td [(t)-6.6 (he 5)]TJ 0.002 Tw 6.96 -0 0 6.96 429.6 169.08 Tm (th)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 435.36 165.12 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(edi)2.6 (t)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (he)10.6 ( A)1.9 (J)-2 (C)2.6 (C)]TJ 0 Tc 0 Tw 8.576 0 Td (-)Tj -0.013 Tc 0.018 Tw 0.337 0 Td [(T)-21.6 (N)-8.4 (M)4.8 ( s)-13 (t)-17.6 (ag)-22.2 (i)-8.4 (ng)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 599.28 169.08 Tm (200)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 610.8 165.12 Tm ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(and )-10.6 (not)-6.7 ( t)-6.6 (o t)-6.6 (he )-10.6 (6)]TJ 0.002 Tw 6.96 -0 0 6.96 690.6 169.08 Tm (th)Tj -0.006 Tc 0.011 Tw 11.04 -0 0 11.04 696.36 165.12 Tm (, 7)Tj -0.002 Tc 0.002 Tw 6.96 -0 0 6.96 708.6 169.08 Tm (th)Tj -0.013 Tc 0.018 Tw 11.04 -0 0 11.04 714.36 165.12 Tm [(,)-17.6 ( or)-17 ( )0.5 (8)]TJ 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page 93 %% Original object ID: 187 0 848 0 obj << /Length 849 0 R >> stream Q q BT /Xi91 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 849 0 obj 245 endobj %% Original object ID: 11431 0 850 0 obj [ 2656 0 R ] endobj %% Contents for page 94 %% Original object ID: 188 0 851 0 obj << /Length 852 0 R >> stream q endstream endobj 852 0 obj 2 endobj %% Contents for page 94 %% Original object ID: 11432 0 853 0 obj << /Length 854 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 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(e)10.5 (m)-5.9 ( w)13.5 (as)-2 ( )]TJ 0 -1.38 Td [(deem)-6 (ed )11.3 (t)-6.6 (o be)10.5 ( t)-6.6 (he)10.6 ( )11.2 (m)-5.9 (os)-2 (t)4.3 ( a)10.5 (ppr)-5.9 (opr)-6 (i)2.6 (at)-6.6 (e)10.5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 197.88 339.84 Tm [(434,)-1.8 (4)-17 (40)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 222.96 335.88 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(C)2.6 (odon)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 3.217 0 Td [(anal)2.6 (y)8.8 (s)-2 (i)2.7 (s)-2.1 ( i)2.7 (s)-2 ( us)-2 (ef)-17.5 (ul)13.5 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )]TJ -21.565 -1.37 Td [(pr)-6 (edi)2.6 (c)-2 (t)-6.6 (i)2.6 (n)10.5 (g)-11.2 ( p)10.5 (r)-5.9 (o)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 125.16 324.72 Tm [(413,)-1.8 (4)-17 (14,)-19.1 (441)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 163.8 320.76 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(P)2 (r)-6 (es)-2.1 (enc)-2 (e o)10.5 (f)-17.4 ( an)10.5 ( ex)8.8 (on 16 )11.2 (m)-5.9 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (on,)4.2 ( ei)2.6 (t)-6.6 (her)4.9 ( )]TJ -12.989 -1.38 Td [(w)2.6 (i)2.6 (t)-6.6 (hi)2.6 (n a s)-2 (por)-6 (adi)]TJ 6.935 0 Td [(c)8.9 ( t)-6.6 (u)10.5 (m)-6 (or)4.9 ( o)10.5 (r)-5.9 ( as)-2 (s)-2 (o)10.5 (c)-2 (i)2.6 (at)-6.6 (ed w)13.5 (i)2.6 (t)-6.6 (h M)15.8 (E)2 (N)2.6 (2)-11.3 (B)2 (,)-6.6 ( i)2.6 (s)-2 ( as)8.8 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (ed w)13.4 (i)2.6 (t)-6.6 (h )]TJ -6.935 -1.37 Td [(m)-6 (or)-6 (e)10.6 ( a)10.5 (gg)-11.2 (r)-5.9 (es)8.9 (s)-2 (i)2.6 (v)8.9 (e di)2.6 (s)-2 (eas)-2 (e.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 148.92 294.36 Tm (442)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 160.44 290.4 Tm ( )Tj -0.002 Tc 0.007 Tw 0.293 0 Td [(M)15.8 (or)-5.9 (e t)-6.6 (han )11.3 (95%)6.5 ( o)10.6 (f)-6.7 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h M)15.8 (E)2 (N)2.6 (2B)2 ( hav)8.9 (e )]TJ -12.696 -1.38 Td [(a m)-6 (u)10.5 (t)-6.6 (at)-6.6 (i)2.6 (on i)2.6 (n)10.5 ( ex)8.8 (on 16 \()4.9 (c)8.9 (odon 918\))4.9 (,)-6.6 ( w)13.5 (her)-6 (eas)-2 ( 2)10.5 (%)]TJ 0 Tc 0 Tw 21.163 0 Td ( )Tj -0.006 Tc 0.006 Tw 0.272 0 Td [(to)-4.4 ( )]TJ -0.002 Tc 0.007 Tw 1.109 0 Td [(3%)6.5 ( hav)8.9 (e a m)4.9 (ut)-6.6 (a)10.6 (t)-6.6 (i)2.6 (on i)2.6 (n )]TJ -22.543 -1.37 Td [(ex)8.8 (on 15 \()-5.9 (c)]TJ 4.663 0 Td [(odon)10.5 ( 883\))5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 127.56 264 Tm (443)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 139.08 260.04 Tm ( )Tj 0.283 0 Td ( )Tj EMC /H2 <>BDC /TT1 1 Tf 0.009 Tc -0.004 Tw -10.75 -2.391 Td [(S)2.1 (ur)-4.1 (g)11.3 (i)-6.5 (ca)10.6 (l)-6.5 ( M)-5.8 (an)11.3 (age)10.7 (m)-4.2 (en)11.3 (t)]TJ 0 Tc 0 Tw 10.467 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw -10.467 -1.696 Td [(S)2 (ur)-5.9 (g)-11.3 (e)10.6 (r)-6 (y)8.9 ( i)2.6 (s)-2 ( t)-6.6 (he)10.6 ( )11.2 (m)-5.9 (ai)2.6 (n t)4.2 (r)-5.9 (eat)4.3 (m)-6 (ent)4.3 ( )11.2 (f)-17.5 (o)10.6 (r)-6 ( M)15.8 (T)-10.6 (C)2.6 (.)4.3 ( )22.1 (W)-36.2 (h)10.5 (i)2.6 (l)2.6 (e no)10.5 ( )11.3 (c)-2 (ur)-6 (at)-6.6 (i)2.6 (v)8.8 (e s)-2 (y)8.9 (s)-2 (t)-6.7 (em)-6 (i)2.7 (c)8.8 ( t)-6.6 (he)10.5 (r)-6 (ap)10.5 (y)8.9 ( )]TJ 0 -1.38 Td [(f)-6.6 (or)5 ( M)15.7 (T)-10.5 (C)2.6 ( i)2.6 (s)-2 ( av)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e,)-6.6 ( )0.5 (v)8.8 (an)-11.3 (det)-6.5 (ani)2.6 (b and )11.2 (c)-2 (aboz)8.9 (ant)]TJ 20.5 0 Td [(i)2.6 (ni)2.6 (b ar)-6 (e)10.5 ( r)-5.9 (ec)-2 (o)10.6 (m)-6 (m)4.9 (ended )11.3 (f)-6.7 (or)4.9 ( )]TJ -20.5 -1.37 Td [(l)2.6 (oc)-2 (al)2.6 (l)-8.2 (y)8.8 ( adv)8.9 (anc)-2 (ed and m)-6 (e)10.6 (t)-6.7 (as)-2 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( M)15.8 (T)-10.6 (C)2.6 ( )11.3 (\()-5.9 (s)-2.1 (ee )]TJ /TT2 1 Tf [(R)2.6 (ec)-2 (u)10.5 (r)-5.9 (r)4.9 (ent)-6.6 ( o)10.5 (r)-5.9 ( P)1.9 (er)4.9 (s)-2 (i)2.6 (s)-2 (t)-6.6 (ent)4.2 ( )]TJ -0.005 Tc 0.005 Tw 0 -1.38 Td [(Dis)-5 (e)-3.3 (a)-3.4 (s)-5 (e)]TJ /TT0 1 Tf 0 Tc 0 Tw 3.598 0 Td ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(in)-3.3 ( t)-9.6 (h)-3.3 (is)-5 ( Dis)-5 (c)-5 (u)-3.3 (s)-5 (s)-5 (io)7.5 (n)-3.4 (\))-8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 158.16 173.28 Tm (444)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 1.983 0 Td [(4)-17 (47)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 183.6 169.32 Tm ( )Tj -0.002 Tc 0.007 Tw 0.293 0 Td [(M)15.8 (T)-10.6 (C)2.6 ( c)-2 (el)2.6 (l)2.6 (s)-2 ( do no)10.5 (t)-6.6 ( c)-2 (onc)-2 (en)10.6 (t)-6.7 (r)-5.9 (a)10.5 (t)-6.6 (e)10.5 ( R)2.6 (A)2 (I)-6.6 (,)4.3 ( and )]TJ -14.793 -1.37 Td [(M)15.8 (T)-10.6 (C)2.6 ( does)-2 ( not)4.2 ( r)-5.9 (es)-1.9 (pon)10.6 (d )11.3 (w)13.5 (e)-11.2 (l)2.6 (l)2.6 ( t)-6.6 (o c)-2 (onv)8.9 (ent)-6.6 (i)2.6 (onal)2.6 ( c)-2 (y)8.8 (t)-6.6 (ot)4.2 (ox)8.9 (i)2.6 (c)-2 ( c)-2 (hem)-6 (ot)-6.6 (her)-6 (apy)8.9 (.)4.3 ( )]TJ -0.013 Tc 0.013 Tw 0 -1.38 Td [(T)-21.6 (h)-11.3 (er)-17 (ef)-28.5 (or)-16.9 (e)-11.4 (,)-6.7 ( )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 77.4 142.92 Tm (131)Tj -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 88.92 138.96 Tm [(I)-6.6 ( i)2.6 (m)-6 (a)10.6 (g)-11.2 (i)2.6 (ng c)8.8 (annot)-6.6 ( be)10.5 ( us)-2 (ed,)4.2 ( and)10.5 ( )0.5 (R)2.6 (A)1.9 (I)-6.6 ( )11.3 (t)4.2 (r)-5.9 (eat)4.2 (m)-5.9 (ent)4.3 ( i)2.6 (s)-2 ( no)10.6 (t)-6.7 ( e)10.5 (f)-6.6 (f)-6.6 (ec)8.9 (t)-6.6 (i)2.6 (v)8.8 (e )]TJ -5.924 -1.37 Td [(i)2.6 (n t)-6.6 (hes)-2 (e pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 (.)-6.6 ( P)1.9 (os)8.9 (t)-6.6 (op)10.5 (er)-6 (at)-6.7 (i)2.7 (v)8.8 (e l)2.6 (ev)8.9 (ot)-6.6 (hy)8.9 (r)-6 (ox)-2 (i)2.6 (ne i)2.6 (s)-2 ( i)2.6 (ndi)2.6 (c)-2 (at)-6.6 (ed )11.2 (f)-17.4 (o)10.5 (r)-6 ( al)2.6 (l)2.6 ( pa)10.6 (t)]TJ 0.002 Tw 29.696 0 Td [(i)2.6 (ent)-6.6 (s)8.9 (;)-6.6 ( )]TJ 0.007 Tw -29.696 -1.38 Td [(how)13.5 (e)-11.2 (v)8.9 (er)-6 (,)-6.6 ( )11.3 (T)-10.6 (S)2 (H)2.6 ( s)-2 (uppr)-6 (e)10.5 (s)-2 (s)-2 (i)2.6 (on i)2.6 (s)-2 ( )0.5 (not)4.2 ( appr)4.9 (opr)-6 (i)2.6 (at)-6.6 (e)10.5 ( bec)8.9 (aus)-2 (e C)2.6 ( c)-2 (el)2.6 (l)2.6 (s)-2 ( l)2.6 (ac)8.9 (k)-2 ( )11.2 (T)-10.5 (S)1.9 (H)2.6 ( )]TJ 0.002 Tw 0 -1.37 Td [(r)-6 (ec)-2 (ept)-6.6 (o)10.5 (r)-5.9 (s)-2 (.)4.2 ( )]TJ 0.007 Tw 4.707 0 Td [(T)-10.6 (hus)8.9 (,)-6.6 ( )11.3 (T)-10.6 (S)2 (H)2.6 ( )11.2 (s)-2 (h)10.6 (oul)2.6 (d be )11.3 (k)-12.9 (ept)4.3 ( i)2.6 (n )11.2 (t)-6.6 (he no)10.5 (r)-6 (m)5 (al)2.6 ( r)-5.9 (an)10.5 (g)-11.2 (e by)8.9 ( ad)10.6 (j)-8.3 (us)-2 (t)-6.6 (i)2.6 (n)10.5 (g t)-6.6 (he)10.5 ( )]TJ -4.707 -1.38 Td [(l)2.6 (ev)8.8 (ot)-6.6 (hy)8.9 (r)-6 (o)-11.2 (x)8.9 (i)2.6 (ne dos)-2 (e)]TJ 0 Tc 0 Tw (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 118.32 82.2 Tm [(413,)-19.1 (41)-17 (4)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 143.64 78.24 Tm ( )Tj 0.272 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw 23.402 39.467 Td [(P)2 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( s)-2 (houl)2.6 (d)10.5 ( be as)8.8 (s)-2 (es)8.9 (s)-2 (ed )11.2 (f)-17.4 (o)10.5 (r)-6 ( hy)8.8 (per)-5.9 (par)-6 (a)10.6 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (di)2.6 (s)-1.9 (m)-6 ( and)10.5 ( )]TJ 0 -1.38 Td [(pheoc)-2 (hr)-6 (om)-6 (o)10.5 (c)-2 (y)8.9 (t)-6.6 (om)-6 (a p)10.6 (r)-6 (eo)10.5 (per)-6 (at)-6.6 (i)2.6 (v)8.9 (el)2.6 (y)8.9 (,)-6.6 ( ev)8.9 (en i)2.6 (n pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (ho hav)8.8 (e appar)-6 (ent)-6.7 (l)2.6 (y)8.9 ( )]TJ 0 -1.37 Td [(s)-2 (por)-6 (adi)2.6 (c)-2 ( di)2.6 (s)-2 (eas)-2 (e)10.6 (,)-6.6 ( bec)-2 (au)10.5 (s)-2 (e t)-6.6 (he)10.6 ( pos)-2 (s)-2 (i)2.6 (bi)2.6 (l)2.6 (i)2.7 (t)-6.7 (y)8.9 ( of)-6.6 ( M)15.8 (E)2 (N)-8.3 (2 s)-2 (houl)2.6 (d di)2.6 (c)-2 (t)-6.6 (a)10.5 (t)-6.6 (e)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.002 Tw 28.924 0 Td [(t)-6.6 (es)8.9 (t)-6.6 (i)2.6 (ng )]TJ -0.004 Tw -28.924 -1.38 Td [(f)-6.6 (or)4.9 ( )-10.6 (a g)-11.2 (e)10.5 (r)-6 (m)-5.9 (l)2.6 (i)2.6 (ne )]TJ /TT2 1 Tf -0.005 Tc 0.005 Tw 6.38 0 Td [(RE)-1 (T)]TJ /TT0 1 Tf 0 Tc 0 Tw 1.989 0 Td ( )Tj -0.013 Tc 0.013 Tw 0.283 0 Td [(pr)-16.9 (o)-11.4 (t)-17.6 (o)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 2.598 0 Td [(onc)-2 (o)10.5 (g)-11.2 (ene )11.2 (m)-5.9 (ut)-6.6 (a)10.5 (t)-6.5 (i)2.6 (on )11.2 (f)-6.6 (or)4.9 ( a)10.5 (l)2.6 (l)2.6 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h M)15.8 (T)-10.6 (C)2.6 (.)-6.6 ( )]TJ -11.25 -1.37 Td [(P)2 (heoc)-2 (hr)-6 (om)-6 (oc)-2 (y)8.8 (t)-6.6 (o)10.6 (m)-6 (as)-2 ( )11.2 (s)-2 (h)10.6 (oul)2.7 (d be r)-5.9 (e)10.5 (m)-6 (ov)8.8 (ed \()-5.9 (e)10.5 (g,)-6.6 ( )]TJ 0.002 Tw [(l)2.6 (ap)10.5 (ar)-5.9 (os)-2 (c)-2 (opi)2.6 (c)-2 ( )]TJ 0 -1.38 Td [(adr)-6 (enal)2.6 (ec)-2 (t)-6.6 (o)10.5 (m)-6 (y)8.9 (\))]TJ 0 Tc 0 Tw 6.87 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(be)10.5 (f)-17.5 (o)10.5 (r)-5.9 (e s)8.9 (ur)5 (g)-11.3 (er)-6 (y)8.9 ( on )11.3 (t)-6.6 (he )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d t)-6.6 (o)10.5 ( a)10.6 (v)8.8 (oi)2.6 (d hy)8.8 (per)-6 (t)-6.6 (ens)-2 (i)2.6 (v)8.9 (e c)-2 (r)-5.9 (i)2.6 (s)-2 (i)2.6 (s)-2 ( )]TJ -7.152 -1.37 Td [(dur)-6 (i)2.7 (ng s)-2 (ur)4.9 (g)-11.2 (e)10.5 (r)-5.9 (y)8.9 ( \()-6 (s)-2 (ee)10.6 ( )]TJ /TT2 1 Tf 0.002 Tw [(P)1.9 (he)10.5 (oc)-2 (hr)-5.9 (om)-6 (oc)8.9 (y)-2 (t)-6.6 (o)10.5 (m)-6 (a/)-6.6 (P)1.9 (a)10.6 (r)-6 (aga)10.5 (ngl)2.7 (i)2.6 (om)]TJ 0 Tc 0 Tw 24.141 0 Td (a)Tj /TT0 1 Tf 0.554 0 Td ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(in)-3.3 ( t)-9.6 (h)-3.3 (e)7.5 ( NCCN )]TJ -0.002 Tc -0.004 Tw -24.978 -1.38 Td [(G)-6.6 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( f)-17.5 (or)5 ( )-10.7 (N)2.7 (eur)-5.9 (oend)10.5 (oc)-2 (r)-5.9 (i)2.6 (ne )]TJ 0.002 Tw [(T)-10.6 (um)4.9 (or)-5.9 (s)]TJ 0.007 Tw 17.174 0 Td [(,)-6.6 ( av)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e)-11.2 ( at)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.005 Tc 0.005 Tw [(www)10.5 (.)-9.6 (NCCN.)-9.6 (o)-3.4 (r)-9 (g)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 737.16 407.64 Tm (\))Tj 0.005 Tc -0.005 Tw 0.326 0 Td (. )Tj ET /CS0 cs 0 0.357 0.6 scn 659.52 405.6 77.64 0.84 re f BT /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 392.52 Tm [(P)2 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h pheoc)-2 (h)10.5 (r)-6 (om)4.9 (oc)-2 (y)8.9 (t)-6.6 (om)-6 (as)-2 ( )11.2 (m)-5.9 (us)8.9 (t)-6.6 ( be)10.6 ( t)4.2 (r)-5.9 (eat)-6.6 (e)10.5 (d pr)-6 (eope)10.5 (r)-5.9 (at)-6.6 (i)2.6 (v)8.9 (el)2.7 (y)8.8 ( )-10.5 (w)13.5 (i)2.6 (t)-6.6 (h )]TJ 0.002 Tw 0 -1.38 Td [(al)2.6 (pha)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 2.772 0 Td [(adr)-6 (ener)4.9 (g)-11.2 (i)2.6 (c)8.9 ( bl)2.7 (oc)8.9 (k)-12.9 (a)10.5 (de \()-5.9 (phenox)8.8 (y)8.9 (benz)8.9 (am)-6 (i)2.6 (ne\))-5.9 ( or)-5.9 ( w)13.4 (i)2.6 (t)-6.6 (h )]TJ 0.002 Tw -2.772 -1.37 Td [(al)2.6 (pha)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 2.772 0 Td [(m)-6 (et)-6.6 (hy)8.9 (l)2.6 (t)-6.6 (y)8.9 (r)-6 (os)-2 (i)2.6 (ne t)-6.6 (o)10.5 ( )11.3 (av)8.9 (oi)2.6 (d a hy)8.9 (per)-6 (t)-6.6 (ens)-2 (i)2.7 (v)8.8 (e c)-2 (r)-6 (i)2.6 (s)-2 (i)2.6 (s)-2 ( dur)-5.9 (i)2.6 (ng s)-2 (u)10.5 (r)4.9 (g)-11.2 (er)-6 (y)8.9 (.)-6.6 ( Fo)10.5 (r)-6 (c)-2 (ed)10.5 ( )]TJ -2.772 -1.38 Td [(hy)8.8 (dr)-6 (at)-6.6 (i)2.6 (on and al)2.6 (pha)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.098 0 Td [(bl)2.6 (oc)8.9 (k)-12.9 (ade)10.5 ( ar)-6 (e)10.6 ( nec)-2 (es)-2 (s)-2 (a)10.6 (r)-6 (y)8.9 ( t)-6.6 (o)10.5 ( pr)4.9 (ev)8.9 (ent)-6.6 ( hy)8.9 (pot)-6.6 (ens)-2 (i)2.6 (on a)10.5 (f)-17.5 (t)-6.6 (e)10.6 (r)-6 ( )]TJ -9.098 -1.37 Td [(t)-6.6 (he )11.3 (t)-6.6 (um)-5.9 (o)10.5 (r)-6 ( i)2.6 (s)8.9 ( r)-6 (e)10.6 (m)-6 (ov)8.8 (ed.)-6.6 ( 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w)13.4 (hos)-2 (e t)-6.6 (u)10.5 (m)-5.9 (or)4.9 ( i)2.6 (s)-2 ( l)2.6 (es)-2 (s)8.9 ( t)-6.7 (han)10.5 ( 1 )]TJ -5.707 -1.38 Td [(c)-2 (m)-6 ( and)10.6 ( )11.2 (f)-17.4 (o)10.5 (r)-6 ( uni)2.6 (l)2.7 (at)-6.6 (e)10.5 (r)-5.9 (al)2.6 ( t)4.3 (hy)8.9 (r)-6 (oi)2.6 (d di)2.6 (s)-2 (eas)-2 (e \()-6 (s)-2 (ee)10.5 ( )]TJ /TT2 1 Tf 0.004 Tc 0.001 Tw [(P)8 (ri)19.5 (ma)5.7 (ry)14.9 ( T)6.3 (re)5.7 (a)16.5 (t)-0.6 (me)5.7 (n)16.5 (t)]TJ /TT0 1 Tf 0 Tc 0 Tw 26.761 0 Td ( )Tj -0.005 Tc -0.001 Tw 0.283 0 Td [(in)-3.3 ( t)-9.6 (h)-3.4 (e)7.6 ( )-10.7 (NCCN )]TJ -0.002 Tc 0.007 Tw -27.043 -1.37 Td [(G)-6.6 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (or)4.9 ( M)15.8 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( )-10.5 ([)4.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d])-6.6 ( C)2.6 (ar)-5.9 (c)-2 (i)2.6 (no)10.6 (m)-6 (a\))4.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 632.52 218.52 Tm [(376,)-19.1 (420)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 657.6 214.56 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(G)-6.6 (i)2.6 (v)8.9 (en t)-6.6 (he r)-6 (i)2.6 (s)8.9 (k)-12.9 (s)-2 ( o)10.6 (f)-6.7 ( )]TJ -23.163 -1.38 Td [(t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( i)2.6 (n v)8.9 (er)-6 (y)8.9 ( y)8.9 (oung c)-2 (hi)2.6 (l)2.6 (dr)-6 (en,)4.3 ( r)-6 (e)10.6 (f)-6.6 (er)4.9 (r)-5.9 (al)2.6 ( t)-6.6 (o)10.6 ( a)10.6 ( s)-2 (ur)4.9 (g)-11.2 (eon)10.5 ( and )11.3 (t)-6.6 (ea)10.5 (m)-5.9 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ 0.002 Tw 0 -1.37 Td [(ex)8.8 (per)-5.9 (i)2.6 (e)]TJ 0.007 Tw [(nc)-2 (e i)2.7 (n pedi)2.6 (at)-6.6 (r)-5.9 (i)2.6 (c)-2 ( )11.2 (t)-6.6 (h)10.6 (y)8.8 (r)-5.9 (oi)2.6 (d s)-2 (ur)-5.9 (ger)-6 (y)8.9 ( i)2.6 (s)-2 ( adv)8.9 (i)2.6 (s)-2 (ed.)]TJ 0 Tc 0 Tw 21.826 0 Td ( )Tj 0.272 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -22.098 -2.38 Td [(I)4.3 (f)-6.7 ( )0.5 (a pa)10.6 (t)-6.6 (i)2.6 (ent)-6.6 ( w)13.5 (i)2.6 (t)-6.6 (h i)2.6 (nher)-6 (i)2.6 (t)-6.6 (ed)10.5 ( )11.3 (di)2.6 (s)-2 (eas)-2 (e i)2.6 (s)-2 ( di)2.5 (a)10.6 (g)-11.2 (nos)-2 (ed ea)10.5 (r)5 (l)2.6 (y)8.8 ( enoug)-11.3 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0 obj << /Length 856 0 R >> stream Q q BT /Xi92 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 856 0 obj 245 endobj %% Contents for page 95 %% Original object ID: 190 0 857 0 obj << /Length 858 0 R >> stream q endstream endobj 858 0 obj 2 endobj %% Contents for page 95 %% Original object ID: 11434 0 859 0 obj << /Length 860 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (32)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(E)2 (805K)2 (,)-6.6 ( V)1.9 (804M)15.8 ( +)-5 ( Y)2 (806C)13.5 (,)-6.6 ( o)10.5 (r)-6 ( V)2 (804M)15.8 ( +)-5 ( S)1.9 (904C)2.6 (\))4.9 ( )]TJ /TT2 1 Tf -0.005 Tc 0.005 Tw [(RE)-1 (T)]TJ /TT0 1 Tf 0 Tc 0 Tw 22.543 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(m)-6 (u)10.6 (t)-6.6 (at)-6.6 (i)2.6 (ons)8.9 ( \()-6 (s)-2 (ee)10.5 ( )]TJ /TT2 1 Tf -0.005 Tc 0.005 Tw [(Clin)-3.3 (ic)-5 (a)-3.4 (l)-11.3 ( )]TJ -0.004 Tc 0.004 Tw -22.826 -1.38 Td [(Pr)-8 (e)-2.3 (s)-4 (e)]TJ -0.002 Tc 0.002 Tw 2.609 0 Td [(nt)-6.6 (a)10.5 (t)-6.6 (i)2.6 (on)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 3.272 0 Td [(i)2.6 (n )11.2 (t)-6.6 (he N)2.6 (C)2.6 (C)2.7 (N)2.6 ( G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (o)10.6 (r)-6 ( M)15.8 (edul)2.6 (l)2.7 (a)-11.3 (r)-5.9 (y)8.9 ( [)4.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d])-6.6 ( C)2.6 (ar)4.9 (c)-2 (i)2.6 (nom)-5.9 (a\))4.9 (,)-6.6 ( )]TJ -5.88 -1.37 Td [(bec)-2 (aus)-2 (e t)-6.7 (he)10.5 (s)-2 (e )]TJ /TT2 1 Tf -0.005 Tc 0.005 Tw [(RE)-1.1 (T)]TJ /TT0 1 Tf 0 Tc 0 Tw 8.761 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(m)-6 (u)10.6 (t)4.2 (at)-6.6 (i)2.6 (ons)-2 ( c)-2 (a)10.5 (r)-5.9 (r)-6 (y)8.9 ( t)-6.6 (he)10.5 ( hi)2.6 (g)-11.2 (h)10.5 (es)-2 (t)4.2 ( r)4.9 (i)2.6 (s)-2 (k)-12.8 ( )11.2 (f)-6.6 (o)10.6 (r)-6 ( M)15.8 (T)-10.6 (C)2.6 ( \()-5.9 (i)2.6 (e)10.5 (,)-6.6 ( l)2.6 (ev)8.9 (el)2.6 ( )]TJ -0.005 Tc 0.005 Tw -9.033 -1.38 Td [(D\))-9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 38.28 472.32 Tm [(413,)-1.8 (4)-17 (14,)-19.1 (44)-16.9 (9)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 77.04 468.36 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -5.13 -2.37 Td [(H)2.6 (ow)13.4 (e)-11.2 (v)8.9 (er)-5.9 (,)-6.6 ( )11.2 (f)-17.4 (or)4.9 ( pat)-6.6 (i)2.7 (en)10.5 (t)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h c)-2 (odon 768)10.5 (,)-6.6 ( 790)10.5 (,)4.3 ( )]TJ [(791,)4.3 ( 8)10.5 (04)]TJ [(,)-6.6 ( and)10.5 ( 891 )]TJ /TT2 1 Tf -0.005 Tc 0.005 Tw [(RE)-1.1 (T)]TJ /TT0 1 Tf 0 Tc 0 Tw 29.478 0 Td ( )Tj 0.004 Tc -0.004 Tw 0.272 0 Td [(\(ri)8.6 (s)14.9 (k)4 ( )]TJ -0.002 Tc 0.007 Tw -29.75 -1.38 Td [(l)2.6 (ev)8.8 (e)-11.2 (l)2.6 ( A)2 (\))-6 ( m)-5.9 (u)10.5 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (ons)-2 (,)-6.6 ( )11.3 (t)-6.6 (he)10.5 ( l)2.6 (et)-6.6 (hal)2.6 (i)2.6 (t)-6.6 (y)8.9 ( o)10.5 (f)-17.5 ( M)15.8 (T)-10.6 (C)2.6 ( )11.3 (m)-5.9 (ay)8.9 ( be l)2.6 (o)10.5 (w)13.5 (er)-5.9 ( t)-6.6 (han w)13.5 (i)2.6 (t)-6.6 (h ot)-6.6 (her)4.9 ( )]TJ /TT2 1 Tf -0.005 Tc 0.005 Tw [(RE)-1 (T)]TJ /TT0 1 Tf 0 Tc 0 Tw 32.348 0 Td ( )Tj -0.002 Tc 0.002 Tw -32.348 -1.37 Td [(m)-6 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (ons)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 74.4 415.8 Tm [(413,)-1.8 (41)-17 (4,)-1.9 (4)-17 (49)-17 (,)-1.8 (45)-17 (0)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 126.72 411.84 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)-6.6 (n )11.3 (pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.7 (h)10.6 (es)-2 (e )]TJ -0.005 Tc -0.001 Tw [(le)-3.4 (s)-5 (s)5.9 ( h)-3.3 (ig)-14.2 (h)]TJ 0 Tc 0 Tw 13.576 0 Td (-)Tj -0.005 Tc -0.001 Tw 0.326 0 Td [(r)-9 (is)5.9 (k)-15.9 ( \()-9 (ie)-3.3 (,)-9.6 ( )-10.7 (lo)-3.3 (w)10.5 (e)-3.4 (r)]TJ 0 Tc 0 Tw 5.87 0 Td (-)Tj -0.011 Tc 0.011 Tw 0.337 0 Td [(r)-15 (i)-6.3 (sk)-11 ( )]TJ -0.005 Tc 0.01 Tw -29.739 -1.38 Td [(le)-3.3 (v)5.8 (e)-14.2 (l A)-1.1 (\))-8.9 ( )]TJ /TT2 1 Tf 0.005 Tw [(RE)-1.1 (T)]TJ /TT0 1 Tf 0 Tc 0 Tw 5.598 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.272 0 Td [(m)-6 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (ons)-2 (,)4.3 ( annual)2.6 ( )]TJ 0.007 Tw 8.141 0 Td [(bas)-2 (al)2.7 ( c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.7 (n t)4.3 (es)-2 (t)-6.6 (i)2.6 (ng and a)]TJ 0.002 Tw 12.804 0 Td [(nnual)2.6 ( )]TJ 0.007 Tw -26.815 -1.37 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2.1 (ound a)10.5 (r)-6 (e )11.2 (r)-5.9 (ec)-2 (o)10.6 (m)-6 (m)-5.9 (e)10.5 (nded;)-6.6 ( )11.2 (t)-6.6 (ot)-6.6 (al)2.6 ( )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.7 (o)10.6 (m)4.9 (y)8.9 ( and c)-2 (ent)-6.6 (r)-5.9 (al)13.5 ( node )]TJ 0 -1.38 Td [(di)2.6 (s)-2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (on )11.3 (m)-6 (ay)8.9 ( be de)10.5 (f)-17.5 (e)10.6 (r)-6 (r)4.9 (ed i)13.5 (f)-17.5 ( )11.3 (t)-6.6 (hes)-2 (e)10.5 ( t)-6.6 (es)8.8 (t)-6.6 (s)-2 ( a)10.6 (r)-6 (e )11.2 (nor)4.9 (m)-5.9 (al)2.6 (,)-6.6 ( )11.3 (t)-6.6 (her)-5.9 (e)10.5 ( i)2.6 (s)-2 ( no)10.5 ( )11.3 (f)-17.5 (a)10.6 (m)-6 (i)2.6 (l)2.6 (y)8.9 ( )]TJ 0 -1.37 Td [(hi)2.6 (s)-2 (t)-6.6 (or)-5.9 (y)8.8 ( o)10.5 (f)-6.6 ( a)10.6 (gg)-11.2 (r)-6 (es)-2 (s)-2 (i)2.6 (v)8.9 (e M)15.8 (T)-10.5 (C)2.6 (,)-6.6 ( and )11.3 (t)-6.6 (he)10.5 ( )11.3 (f)-17.5 (a)10.5 (m)-5.9 (i)2.6 (l)2.6 (y)8.9 ( ag)-11.2 (r)-5.9 (ees)8.8 ( )11.3 (t)-6.6 (o de)10.5 (f)-6.6 (er)4.9 ( s)-2 (ur)4.9 (g)-11.2 (e)10.6 (r)-6 (y)8.9 ( \()-6 (s)-2 (ee)10.5 ( )]TJ /TT2 1 Tf 0 -1.38 Td [(A)2 (ddi)2.6 (t)-6.6 (i)2.6 (onal)2.7 ( W)-14.6 (o)10.6 (r)-6 (k)-2 (up)]TJ /TT0 1 Tf 0 Tc 0 Tw 8.087 0 Td ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(in)-3.3 ( t)-9.6 (h)-3.3 (e)7.5 ( )11.2 (NCCN G)-9.6 (u)-3.3 (id)-3.4 (e)-3.3 (lin)-3.4 (e)-3.3 (s)-5 ( )]TJ -0.002 Tc 0.007 Tw 10.837 0 Td [(f)-17.5 (or)4.9 ( M)15.8 (e)-11.2 (dul)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( [)-6.6 (T)-10.5 (hy)8.9 (r)-5.9 (oi)2.6 (d])-6.7 ( )]TJ 0.002 Tw -19.207 -1.37 Td [(C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a\))4.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 83.52 324.72 Tm [(413,)-1.8 (4)-17 (14,)-19.1 (45)-16.9 (1,)-1.8 (4)-17 (52)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 135.84 320.76 Tm ( )Tj -0.002 Tc 0.007 Tw 0.293 0 Td [(D)2.6 (el)2.6 (ay)-2 (i)2.6 (ng)-11.2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (dec)-2 (t)-6.6 (o)10.5 (m)-5.9 (y)8.8 ( )11.3 (m)-6 (ay)8.9 ( al)2.6 (s)-2 (o be app)10.5 (r)-5.9 (opr)-6 (i)2.6 (at)-6.6 (e)10.5 ( )]TJ -10.467 -1.38 Td [(f)-6.6 (or)4.9 ( c)-2 (hi)2.6 (l)2.6 (dr)-6 (en w)13.5 (i)2.6 (t)-6.6 (h l)2.6 (ow)13.5 (er)]TJ 0 Tc 0 Tw 9.63 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(r)-6 (i)2.7 (s)-2 (k)-2 ( m)-6 (u)10.5 (t)-6.6 (at)-6.7 (i)2.7 (ons)8.8 ( \()-5.9 (i)2.6 (e,)4.3 ( l)2.6 (ev)8.9 (el)2.6 ( A)1.9 (\))-5.9 ( )11.3 (bec)-2 (aus)-2 (e o)10.6 (f)-6.7 ( )11.3 (t)-6.6 (h)]TJ [(e l)2.6 (at)-6.6 (e)10.5 ( ons)-2 (e)10.5 (t)-6.6 ( )]TJ -9.967 -1.37 Td [(o)10.5 (f)-17.4 ( M)15.8 (T)-10.5 (C)2.6 ( dev)8.8 (el)2.6 (opm)-5.9 (ent)4.2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 128.76 294.36 Tm [(413,)-1.8 (4)-17 (14,)-19.1 (450)-16.9 (,)-1.9 (4)-17 (51,)-19.1 (45)-17 (3)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 194.76 290.4 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 ( s)-2 (t)-6.6 (udy)8.8 ( )11.3 (f)-17.5 (ound)10.5 ( )11.3 (no ev)8.9 (i)2.6 (denc)-2 (e o)10.5 (f)-17.4 ( )]TJ -15.793 -1.38 Td [(per)-6 (s)-2 (i)2.7 (s)-2 (t)-6.6 (en)10.5 (t)-6.6 ( o)10.6 (r)-6 ( )11.3 (r)-6 (ec)-2 (ur)4.9 (r)-5.9 (ent)4.2 ( M)4.9 (T)-10.5 (C)2.6 ( 5)10.5 ( y)8.9 (ear)-6 (s)-2 ( o)10.5 (r)-5.9 ( )11.3 (m)-6 (or)-5.9 (e)10.5 ( a)10.5 (f)-6.6 (t)-6.6 (er)4.9 ( pr)-5.9 (ophy)8.9 (l)2.6 (ac)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (o)10.5 (t)-6.6 (al)2.7 ( )]TJ 0 -1.37 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( i)2.6 (n y)8.9 (oung p)10.5 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h R)2.6 (E)12.9 (T)-10.6 ( )11.3 (m)-6 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (ons)-2 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( M)15.7 (E)2 (N)2.6 (2A)1.9 (;)-6.6 ( l)2.6 (ong)-11.2 (e)10.5 (r)-5.9 ( )]TJ -0.005 Tc 0.005 Tw 0 -1.37 Td [(f)-9.6 (o)-3.4 (llo)-3.3 (w)]TJ 0 Tc 0 Tw 2.533 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up i)2.6 (s)-2 ( nec)-2 (es)-2 (s)-2 (ar)-5.9 (y)8.8 ( t)-6.6 (o)10.5 ( )0.5 (det)-6.7 (e)10.6 (r)-6 (m)-5.9 (i)2.6 (ne i)13.5 (f)-6.7 ( )11.3 (t)-6.6 (hes)-2 (e pa)10.5 (t)-6.6 (i)2.6 (e)10.6 (nt)-6.6 (s)-2 ( a)10.5 (r)-5.9 (e c)-2 (u)10.5 (r)-5.9 (ed.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 328.8 248.88 Tm (454)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 340.32 244.92 Tm ( )Tj 0.272 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -28.967 -2.38 Td [(V)2 (ar)-5.9 (i)2.6 (at)-6.6 (i)2.6 (ons)-2 ( i)2.6 (n s)-2 (u)10.5 (r)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( s)-2 (t)4.2 (r)5 (at)-6.6 (e)10.5 (g)-11.2 (y)8.9 ( )11.3 (f)-17.5 (or)4.9 ( M)15.8 (T)-10.5 (C)2.6 ( depend o)10.5 (n )0.5 (t)-6.7 (he)10.5 ( r)-5.9 (i)2.6 (s)8.8 (k)-2 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( l)2.6 (oc)-2 (or)-6 (e)10.6 (g)-11.2 (i)2.6 (ona)10.5 (l)2.6 ( )]TJ 0 -1.37 Td [(node m)-5.9 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (a)10.5 (s)-2 (es)-2 ( and)10.5 ( on)10.5 ( w)13.5 (het)-6.6 (her)-6 ( s)-2 (i)2.6 (m)-5.9 (ul)13.5 (t)-6.6 (aneous)-2 ( p)10.5 (ar)-5.9 (at)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d r)-6 (e)10.6 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (on )11.3 (f)-6.6 (or)5 ( )]TJ 0.002 Tw 0 -1.38 Td [(hy)8.8 (per)-5.9 (par)-6 (at)-6.6 (hy)8.9 (r)-6 (oi)2.6 (di)2.6 (s)]TJ 0 Tc 0.005 Tw 8.196 0 Td [(m)-4 ( i)4.6 (s )0.5 (n)12.5 (e)1.6 (ce)1.7 (ssa)1.6 (r)-3.9 (y)10.8 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 190.56 192.24 Tm [(413,)-1.8 (4)-17 (14)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 215.64 188.28 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 ( bi)2.6 (l)2.6 (at)-6.6 (er)-5.9 (al)2.6 ( c)-2 (ent)-6.6 (r)-5.9 (al)13.5 ( nec)8.9 (k)-12.9 ( di)2.6 (s)-2 (s)-2 (e)10.5 (c)-2 (t)-6.6 (i)2.6 (on )]TJ -17.685 -1.37 Td [(\()-6 (l)2.7 (ev)8.9 (el)2.7 ( V)2 (I)-6.6 (\))-6 ( c)-2 (an)10.5 ( be c)-2 (ons)-2 (i)2.6 (de)10.5 (r)-6 (ed )11.2 (f)-6.6 (or)4.9 ( al)2.6 (l)2.6 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h M)4.9 (E)]TJ 22.652 0 Td [(N)2.6 (2B)1.9 (.)-6.6 ( For)4.9 ( t)-6.6 (hos)-2 (e)10.5 ( )]TJ -22.652 -1.38 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h M)15.8 (E)2 (N)2.6 (2A)1.9 ( )-10.5 (w)13.5 (h)-11.2 (o under)4.9 (g)-11.3 (o)10.6 ( pr)-5.9 (ophy)8.9 (l)2.6 (ac)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.2 (t)4.3 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 (,)-6.6 ( t)-6.6 (he)10.6 (r)-6 (apeu)10.5 (t)-6.6 (i)2.6 (c)-2 ( )]TJ 0 -1.37 Td [(i)2.6 (ps)-2 (i)2.6 (l)2.6 (at)-6.6 (er)-6 (al)2.6 ( or)-5.9 ( bi)2.7 (l)2.6 (at)-6.6 (e)10.5 (r)-5.9 (al)2.6 ( c)-2 (en)10.5 (t)-6.6 (r)-6 (al)2.6 ( nec)8.9 (k)-2 ( di)2.6 (s)-2 (s)-1.9 (ec)8.9 (t)-6.6 (i)2.6 (on \()-6 (l)2.6 (ev)8.8 (el)2.6 ( V)2 (I)-6.6 (\))4.9 ( i)2.6 (s)-2 ( r)-6 (e)10.5 (c)-2 (om)4.9 (m)-5.9 (ended i)13.5 (f)-6.6 ( )]TJ 0 -1.38 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( hav)8.9 (e an)10.5 ( i)2.6 (nc)-2 (r)-6 (eas)8.9 (ed c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n or)4.9 ( C)2.6 (E)2 (A)1.9 ( t)4.3 (es)-2 (t)4.3 ( or)5 ( i)13.4 (f)-17.5 ( )0.5 (ul)2.6 (t)4.3 (r)-6 (as)-2 (ound)10.6 ( s)-2 (how)13.4 (s)-2 ( a )]TJ 0 -1.37 Td [(t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d or)-5.9 ( nodal)]TJ 0 Tc 0 Tw 6.87 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(abnor)4.9 (m)-5.9 (a)10.5 (l)2.6 (i)2.6 (t)-6.6 (y)8.9 (.)-6.6 ( S)1.9 (i)2.6 (m)-5.9 (i)2.6 (l)2.6 (ar)-6 (l)2.6 (y)8.9 (,)-6.6 ( m)-6 (or)-6 (e ex)8.9 (t)-6.6 (en)10.6 (s)-2.1 (i)2.7 (v)8.8 (e l)-8.3 (y)8.9 (m)-6 (ph node )]TJ -7.152 -1.38 Td [(di)2.6 (s)-2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (on \()-5.9 (l)2.6 (ev)8.9 (el)2.6 (s)-2 ( I)4.2 (I)]TJ 0 Tc 0 Tw 8.424 0 Td <96>Tj -0.002 Tc 0.007 Tw 0.554 0 Td [(V)2 (\))-6 ( i)2.6 (s)8.9 ( c)-2 (ons)-2 (i)2.6 (der)-6 (ed)10.5 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )11.3 (t)-6.7 (hes)-2 (e pa)10.5 (t)4.2 (i)2.6 (ent)-6.7 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h pr)-5.9 (i)2.6 (m)-6 (a)10.5 (r)-5.9 (y)8.9 ( )]TJ 0.004 Tc 0.001 Tw -8.978 -1.37 Td [(t)-0.6 (u)5.7 (mo)16.5 (r\(s)14.9 (\) 1)]TJ 0 Tc 0 Tw 4.543 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(c)8.9 (m)-6 ( o)10.5 (r)-5.9 ( l)2.6 (ar)5 (g)-11.3 (e)10.6 (r)-6 ( i)13.5 (n di)2.6 (am)-5.9 (et)-6.6 (e)10.6 (r)-6 ( )11.3 (\()-6 (>)-4.9 (0)10.5 (.)-6.6 (5 )11.3 (c)-2 (m)4.9 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )11.2 (pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h M)15.8 (E)1.9 (N)2.6 (2B)1.9 (\))-5.9 ( or)-5.9 ( )]TJ -4.826 -1.38 Td [(f)-6.6 (or)4.9 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h c)-2 (ent)4.2 (r)-5.9 (al)2.6 ( c)8.9 (om)-6 (par)4.9 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( l)2.6 (y)8.9 (m)-5.9 (ph node)10.5 ( )11.3 (m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 ( \()]TJ -0.013 Tc 0.013 Tw 27.761 0 Td [(s)-13 (e)-11.3 (e )]TJ /TT2 1 Tf 0.004 Tc 0.001 Tw 6.793 40.5 Td [(P)8 (ri)8.6 (ma)5.7 (ry)14.9 ( T)6.3 (re)5.6 (a)16.5 (t)-0.6 (me)5.6 (n)16.5 (t)]TJ /TT0 1 Tf 0 Tc 0 Tw 8.25 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (n t)-6.6 (he)10.5 ( N)2.6 (C)2.7 (C)2.6 (N)2.6 ( G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-1.9 ( )11.2 (f)-17.5 (o)10.6 (r)-6 ( M)15.8 (edul)2.6 (l)2.7 (ar)-5.9 (y)8.8 ( [)-6.6 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d])-6.6 ( )]TJ 0.002 Tw -8.533 -1.38 Td [(C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a\))4.9 (.)-6.6 ( )]TJ 0 Tc 0 Tw 5.707 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -5.707 -2.37 Td [(W)-25.4 (i)13.5 (t)4.2 (h a)10.5 ( c)-2 (onc)-2 (u)10.6 (r)-6 (r)-6 (en)10.5 (t)-6.6 ( di)2.6 (a)10.5 (g)-11.2 (no)10.6 (s)-2.1 (i)2.7 (s)-2 ( o)10.5 (f)-6.6 ( hy)8.9 (per)-5.9 (par)-6 (at)-6.6 (hy)8.9 (r)-6 (oi)2.6 (di)2.6 (s)-2 (m)-5.9 ( i)2.6 (n M)15.8 (E)2 (N)2.6 (2A)2 ( or)-5.9 ( )11.3 (f)-6.7 (am)-6 (i)2.7 (l)2.6 (i)2.6 (al)2.6 ( )]TJ 0 -1.38 Td [(M)15.8 (T)-10.6 (C)2.6 (,)-6.6 ( t)-6.6 (he)10.5 ( s)-2 (ur)5 (g)-11.3 (eon)10.6 ( s)-2 (houl)13.5 (d l)2.7 (eav)8.8 (e or)-5.9 ( aut)4.2 (ot)4.3 (r)-6 (ans)-2 (pl)2.6 (ant)4.2 ( t)-6.6 (he)10.5 ( e)10.5 (q)-11.2 (ui)2.6 (v)8.8 (al)2.6 (ent)-6.6 ( m)-6 (as)-2 (s)8.9 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.37 Td [(one nor)4.9 (m)-6 (al)2.6 ( par)-6 (a)10.6 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )11.3 (gl)2.6 (and i)2.6 (f)]TJ 0 Tc 0 Tw 13.739 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(m)-6 (ul)2.6 (t)-6.6 (i)2.6 (g)-11.2 (l)2.6 (andul)2.6 (ar)4.9 ( hy)8.9 (per)-5.9 (pl)2.6 (as)-2 (i)2.6 (a )0.5 (i)2.5 (s)-2 ( pr)-6 (es)-2 (e)10.5 (nt)4.2 (.)-6.6 ( )]TJ -14.011 -1.38 Td [(C)2.6 (r)-5.9 (y)8.8 (opr)-5.9 (es)-2 (er)-6 (v)8.9 (at)-6.6 (i)2.7 (on o)10.6 (f)-6.6 ( r)-6 (es)-2 (e)10.5 (c)-2 (t)-6.6 (ed pa)10.6 (r)-6 (at)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d )11.3 (t)-6.6 (i)2.6 (s)-2 (s)-2 (ue s)8.9 (houl)2.7 (d be c)-2 (ons)-2 (i)2.6 (der)-5.9 (ed)10.5 ( )0.5 (t)-6.7 (o)10.6 ( )]TJ 0 -1.37 Td [(al)2.6 (l)2.6 (o)-11.2 (w)13.4 ( f)-17.4 (u)10.5 (t)-6.6 (ur)-5.9 (e)10.5 ( i)2.6 (m)-6 (pl)2.6 (ant)-6.6 (a)10.5 (t)-6.6 (i)2.6 (on )11.3 (i)2.6 (n t)-6.7 (he ev)8.9 (ent)4.2 ( o)10.6 (f)-6.6 ( i)2.6 (at)-6.6 (r)-5.9 (o)10.5 (g)-11.2 (eni)2.6 (c)8.8 ( )0.5 (hy)8.9 (popar)-6 (at)-6.6 (hy)8.9 (r)-6 (oi)2.6 (di)2.7 (s)-2 (m)-6 (.)4.3 ( )]TJ 0 -1.38 Td [(D)2.6 (i)2.6 (s)-2 (f)-17.5 (i)13.5 (g)-11.2 (ur)-6 (i)2.6 (n)10.5 (g)-11.2 ( )11.3 (r)-6 (adi)2.6 (c)-1.9 (al)2.6 ( node)10.5 ( )11.3 (di)2.6 (s)-2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (ons)-2 ( do)10.6 ( not)4.2 ( i)2.6 (m)-5.9 (pr)-5.9 (o)10.5 (v)8.9 (e pr)-6 (og)-11.3 (nos)-2.1 (i)2.7 (s)8.8 ( and a)10.5 (r)-5.9 (e n)]TJ -0.013 Tc 0.013 Tw [(ot)-6.8 ( )]TJ -0.002 Tc 0.007 Tw 0 -1.37 Td [(i)2.6 (ndi)2.6 (c)-2 (at)-6.6 (ed.)-6.6 ( )11.2 (I)-6.6 (n )11.3 (t)-6.7 (he p)10.6 (r)-6 (es)-2 (enc)8.8 (e o)10.5 (f)-6.6 ( )11.3 (g)-11.3 (r)-5.9 (os)-2 (s)-2 (l)2.6 (y)8.8 ( i)2.6 (nv)8.9 (as)-2 (i)2.6 (v)8.9 (e )0.5 (di)2.6 (s)-2 (e)-11.2 (as)-2 (e,)-6.6 ( )11.3 (m)-6 (or)-6 (e)10.5 ( ex)8.8 (t)-6.6 (ended )]TJ 0 -1.38 Td [(pr)-6 (oc)-2 (edur)-5.9 (es)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h r)-6 (es)-2 (ec)8.8 (t)-6.6 (i)2.6 (on o)10.6 (f)-6.7 ( )0.5 (i)2.6 (nv)8.9 (ol)-8.2 (v)8.8 (ed nec)-2 (k)-2 ( s)-2.1 (t)4.3 (r)-5.9 (uc)8.9 (t)4.2 (ur)-6 (es)-2 ( )11.3 (m)-6 (ay)8.8 ( be app)10.6 (r)-6 (opr)-5.9 (i)2.6 (at)-6.6 (e)10.5 (.)4.3 ( )]TJ 0.002 Tw 0 -1.37 Td [(Func)-2 (t)-6.6 (i)2.6 (on)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 4.163 0 Td [(pr)-6 (e)10.5 (s)-2 (er)-6 (v)8.9 (i)2.6 (ng)-11.2 ( app)10.6 (r)4.9 (oac)-2 (hes)-2 ( ar)-5.9 (e)10.5 ( pr)-6 (e)10.5 (f)-6.6 (er)4.9 (r)-6 (ed)10.5 (.)-6.6 ( )11.3 (I)-6.7 (n )11.3 (s)-2 (om)-5.9 (e pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 (,)-6.6 ( M)15.7 (T)-10.5 (C)2.6 ( i)2.6 (s)8.9 ( )]TJ -4.163 -1.38 Td [(di)2.6 (ag)-11.2 (nos)-2 (ed a)10.5 (f)-6.6 (t)4.3 (er)5 ( t)-6.5 (hy)8.9 (r)-6 (oi)2.6 (d s)8.9 (ur)4.9 (g)-11.3 (er)-6 (y)8.9 (.)-6.6 ( )11.3 (I)-6.6 (n )11.3 (t)-6.6 (h)]TJ [(es)-2 (e)10.5 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 (,)4.2 ( addi)2.6 (t)-6.6 (i)2.6 (onal)2.6 ( w)13.5 (or)-5.9 (k)-12.9 (up)10.6 ( i)2.6 (s)-2 ( )]TJ 0 -1.37 Td [(r)-6 (ec)-2 (om)5 (m)-6 (ended)10.5 ( t)-6.6 (o)10.6 ( as)-2 (c)-2 (er)4.9 (t)-6.6 (a)10.5 (i)2.6 (n w)13.5 (het)-6.6 (her)-5.9 ( t)-6.6 (hey)8.9 ( hav)8.9 (e R)2.6 (E)1.9 (T pr)-6 (o)10.6 (t)-6.7 (o)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 25.38 0 Td [(onc)-2 (o)10.5 (g)-11.2 (ene)10.6 ( )]TJ 0.007 Tw -25.38 -1.38 Td [(m)-6 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (ons)-2 ( )11.3 (\()-6 (e)10.6 (g)-11.3 (,)4.3 ( ex)8.9 (ons)-2 ( 10,)4.3 ( 11,)4.3 ( 13)]TJ 0 Tc 0 Tw <96>Tj -0.002 Tc 0.007 Tw 14.522 0 Td [(16\))4.9 (,)-6.6 ( w)13.5 (hi)2.6 (c)-2 (h w)13.5 (i)-8.3 (l)2.6 (l)2.6 ( det)-6.6 (er)4.9 (m)-6 (i)2.7 (ne w)13.4 (het)-6.7 (her)-5.9 ( )11.3 (t)-6.7 (hey)8.9 ( )]TJ -14.522 -1.37 Td [(need addi)2.6 (t)-6.6 (i)2.6 (onal)2.7 ( s)-2 (ur)4.9 (g)-11.2 (e)10.5 (r)-5.9 (y)8.8 ( \()4.9 (eg,)-6.6 ( c)-2 (o)10.6 (m)-6 (pl)2.6 (et)-6.6 (i)2.6 (on )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)4.3 (om)-5.9 (y)8.9 ( and/)-6.6 (or)4.9 ( nec)8.9 (k)-2 ( )]TJ -0.004 Tw 0 -1.38 Td [(di)2.6 (s)-2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (on\))-5.9 (;)4.2 ( g)-11.2 (enet)-6.6 (i)2.6 (c)8.9 ( )-10.6 (c)]TJ 0.007 Tw 9.315 0 Td [(oun)10.5 (s)-2 (el)2.6 (i)2.6 (ng)-11.3 ( s)-2 (houl)2.6 (d be)10.5 ( c)-2 (ons)-2 (i)2.6 (de)10.5 (r)-5.9 (ed )11.2 (\()-5.9 (s)-2 (ee )]TJ /TT2 1 Tf 0.002 Tw [(A)2 (ddi)2.6 (t)-6.6 (i)2.6 (onal)2.6 ( )]TJ -0.013 Tc 0.013 Tw -9.315 -1.37 Td [(W)-25.5 (or)-17 (k)-13 (u)-11.3 (p)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 3.717 0 Td [(i)2.6 (n t)-6.6 (he)10.5 ( N)2.6 (C)2.6 (C)2.7 (N)2.6 ( G)-6.6 (u)10.6 (i)2.6 (del)2.6 (i)2.6 (nes)-2 ( f)-17.5 (o)10.6 (r)-6 ( M)15.8 (edul)2.6 (l)2.7 (ar)-5.9 (y)8.8 ( [)-6.6 (Thy)8.8 (r)-5.9 (oi)2.7 (d])-6.6 ( C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (\))-6 (.)4.3 ( )]TJ 0 Tc 0 Tw 26.739 0 Td ( )Tj EMC /H2 <>BDC /TT1 1 Tf 0.009 Tc 0.007 Tw -30.457 -2.391 Td [(A)24.5 (d)-10.4 (j)4.3 (u)-10.4 (v)10.7 (ant)-5.8 ( )0.5 (R)2.7 (T)]TJ /TT0 1 Tf 0 Tc 0 Tw 5.967 0 Td ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -6.25 -1.696 Td [(E)2 (B)1.9 (R)2.6 (T)-10.6 ( and)10.5 ( I)-6.6 (M)15.8 (R)2.6 (T)-10.6 ( hav)8.9 (e n)10.5 (ot)-6.6 ( been)10.6 ( ade)10.5 (q)-11.2 (uat)-6.6 (el)2.6 (y)8.9 ( s)-2 (t)-6.6 (udi)13.5 (ed as)-2 ( ad)10.5 (j)-8.2 (uv)8.9 (ant)-6.6 ( )11.3 (t)-6.7 (her)-5.9 (apy)8.9 ( i)13.5 (n )]TJ -0.018 Tc 0.018 Tw 0 -1.38 Td [(MT)-26.6 (C)-13.4 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 431.88 203.64 Tm [(307)-16.9 (,)-1.9 (41)-17 (3,)-19.1 (455)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 470.64 199.68 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(S)2 (l)-8.3 (i)2.6 (g)-11.2 (ht)-6.6 ( i)13.5 (m)-5.9 (pr)4.9 (ov)8.9 (em)-6 (ent)-6.5 (s)-2.1 ( )0.5 (i)2.5 (n l)2.6 (oc)-2 (al)2.6 ( di)2.6 (s)-2 (eas)8.9 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 16.457 0 Td [(f)-17.5 (r)4.9 (ee s)-2 (u)10.6 (r)-6 (v)8.9 (i)2.6 (v)8.9 (a)-11.3 (l)2.7 ( hav)8.8 (e )]TJ -22.685 -1.37 Td [(been r)-5.9 (epo)10.5 (r)-6 (t)-6.6 (ed)10.5 ( a)10.5 (f)-6.6 (t)-6.6 (er)4.9 ( E)1.9 (B)2 (R)2.6 (T )11.3 (f)-17.5 (o)10.5 (r)-6 ( s)-1.9 (el)2.6 (ec)8.8 (t)-6.6 (ed pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 (,)-6.6 ( s)8.8 (uc)-2 (h as)-2 ( )11.3 (t)-6.6 (hos)-2 (e)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ 0 -1.38 Td [(ex)8.8 (t)-6.6 (r)-5.9 (at)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (dal)2.7 ( i)2.6 (nv)8.9 (as)-2 (i)2.6 (on or)-5.9 ( ex)8.9 (t)-6.6 (ens)-2 (i)2.6 (v)8.9 (e )]TJ [(l)2.6 (oc)-2 (or)-5.9 (eg)-11.2 (i)2.6 (onal)2.6 ( n)10.5 (ode i)2.6 (nv)8.9 (ol)-8.2 (v)8.8 (em)-5.9 (ent)-6.5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 731.64 173.28 Tm (456)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 743.16 169.32 Tm ( )Tj 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on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 862 0 obj 245 endobj %% Contents for page 96 %% Original object ID: 192 0 863 0 obj << /Length 864 0 R >> stream q endstream endobj 864 0 obj 2 endobj %% Contents for page 96 %% Original object ID: 11435 0 865 0 obj << /Length 866 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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de)10.5 (t)-6.6 (ec)-2 (t)-6.6 (abl)2.6 (e)10.5 ( bas)-2 (al)2.6 ( )]TJ 0 -1.37 Td [(c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n or)-6 ( el)2.6 (ev)8.9 (at)-6.6 (ed C)2.6 (E)12.8 (A)2 ( w)13.5 (ho hav)8.8 (e neg)-11.2 (at)-6.6 (i)2.6 (v)8.9 (e i)2.6 (m)5 (ag)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( and)10.5 ( w)13.5 (ho ar)-6 (e )]TJ -0.004 Tw 0 -1.38 Td [(as)-2 (y)8.8 (m)-5.9 (pt)-6.6 (om)-6 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( m)-5.9 (ay)8.9 ( )-10.6 (be f)-17.4 (ol)13.5 (l)2.6 (o)-11.2 (w)13.5 (ed )-10.6 (\()-6 (s)-2 (ee )]TJ /TT2 1 Tf -0.005 Tc 0.005 Tw 16.13 0 Td [(S)-1 (u)7.5 (r)-9 (v)-5 (e)-3.3 (illa)-3.4 (n)-3.3 (c)-5 (e)]TJ /TT0 1 Tf 0 Tc 0 Tw 5.413 0 Td ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(in)-3.3 ( t)-9.6 (h)-3.3 (e)7.5 ( NCCN G)-9.6 (u)-3.4 (id)-3.3 (e)-3.4 (lin)-3.3 (e)-3.4 (s)-5 ( )]TJ -0.002 Tc 0.007 Tw -21.826 -1.37 Td [(f)-6.6 (or)5 ( M)15.7 (edul)-8.3 (l)2.6 (ar)-5.9 (y)8.8 ( [)-6.6 (T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d])]TJ 0 Tc 0 Tw 9.913 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a\))4.9 (.)-6.6 ( P)2 (a)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h a bas)-2 (al)2.6 ( s)-2 (e)10.6 (r)-6 (um)5 ( c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n )]TJ -0.004 Tw -10.196 -1.38 Td [(v)8.9 (al)2.6 (ue )-10.6 (g)-11.2 (r)-5.9 (eat)-6.6 (e)10.5 (r)-6 ( t)-6.6 (han)10.5 ( )-10.6 (1000 pg/)-6.6 (m)-6 (L)]TJ 0 Tc 0 Tw 13.576 0 Td <97>Tj -0.002 Tc 0.007 Tw [(and w)13.4 (i)2.7 (t)-6.7 (h no obv)8.9 (i)2.6 (ous)-2 ( M)15.8 (T)-10.6 (C)2.6 ( i)2.6 (n t)-6.7 (he)10.5 ( nec)8.9 (k)-2 ( and)10.5 ( )]TJ -0.004 Tw -13.576 -1.37 Td [(upper)-5.9 ( m)-5.9 (edi)2.6 (as)-2 (t)-6.6 (i)2.6 (num)]TJ 0 Tc 0 Tw 8.478 0 Td <97>Tj -0.002 Tc 0.007 Tw [(pr)-6 (o)10.5 (babl)2.6 (y)8.9 ( hav)8.8 (e di)2.6 (s)-2 (t)-6.6 (ant)-6.6 ( m)-5.9 (e)10.5 (t)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)-2 (,)4.3 ( )11.2 (m)-5.9 (os)-1.9 (t)4.2 ( l)2.6 (i)2.6 (k)-12.8 (el)2.6 (y)8.9 ( i)2.6 (n t)-6.6 (he)10.5 ( )]TJ -8.478 -1.38 Td [(l)2.6 (i)-8.3 (v)8.9 (er)-6 (.)-6.6 ( H)2.6 (ow)13.4 (ev)8.9 (er)-5.9 (,)-6.6 ( oc)-2 (c)-2 (as)-2 (i)2.6 (onal)2.6 (l)-8.2 (y)8.9 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( hav)8.8 (e )11.3 (r)-6 (el)2.6 (at)-6.6 (i)2.6 (v)8.9 (el)2.7 (y)8.8 ( l)2.6 (o)-11.2 (w)13.5 ( s)-2 (er)-5.9 (um)]TJ 0 Tc 0 Tw 27.533 0 Td ( )Tj -0.004 Tc 0.009 Tw 0.283 0 Td [(C)0.6 (EA a)-2.3 (n)-2.4 (d)8.6 ( )]TJ -0.002 Tc 0.007 Tw -27.815 -1.37 Td [(c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n l)2.6 (ev)8.9 (el)2.6 (s)-2 ( but)-6.6 ( hav)8.9 (e ex)8.9 (t)-6.6 (ens)-2 (i)2.6 (v)8.9 (e m)-6 (et)-6.6 (as)8.9 (t)-6.6 (at)-6.7 (i)2.7 (c)8.8 ( di)2.6 (s)-2 (eas)-2 (e;)-6.7 ( i)2.6 (ni)2.6 (t)-6.6 (i)2.6 (al)2.6 ( )]TJ 0 -1.38 Td [(pos)-2 (t)-6.6 (oper)-6 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e )0.5 (i)2.6 (m)-6 (ag)-11.2 (i)2.6 (n)10.6 (g i)2.6 (s)-2 ( )11.3 (t)-6.6 (her)-6 (e)10.6 (f)-6.6 (or)-5.9 (e)10.5 ( r)-6 (eas)-2 (onabl)2.6 (e)10.6 ( des)8.8 (pi)2.6 (t)-6.6 (e )0.5 (t)-6.7 (he)10.5 ( abs)-2 (enc)-2 (e)10.6 ( o)10.6 (f)-6.6 ( v)8.8 (er)-6 (y)8.9 ( )]TJ 0.004 Tc -0.01 Tw 0 -1.37 Td [(h)5.7 (i)8.6 (g)-5.3 (h)5.7 ( )-10.6 (s)4 (e)16.5 (ru)16.6 (m ma)5.7 (r)10.9 (k)-6.9 (e)16.5 (rs)14.9 (.)]TJ 0 Tc 0 Tw 9.087 0 Td ( )Tj 0.272 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -9.359 -2.37 Td [(T)-10.6 (he)10.5 ( pr)-6 (o)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)8.9 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( pa)10.5 (t)-6.6 (i)2.6 (ent)4.3 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h pos)-2 (t)-6.6 (oper)-6 (a)10.6 (t)-6.7 (i)2.7 (v)8.8 (e hy)8.9 (per)-5.9 (c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (nem)-5.9 (i)2.6 (a )]TJ 0 -1.38 Td [(depends)-2 ( pr)-6 (i)13.5 (m)-6 (ar)-6 (i)2.6 (l)2.7 (y)8.8 ( on )]TJ [(t)-6.6 (he)10.5 ( ex)8.9 (t)-6.6 (ent)-6.6 ( o)10.5 (f)-6.6 ( di)2.6 (s)-2 (eas)-2 (e)10.5 ( a)10.5 (t)-6.6 ( )11.3 (t)-6.6 (he )11.3 (t)-6.7 (i)2.6 (m)-5.9 (e o)10.6 (f)-6.6 ( i)2.6 (ni)2.6 (t)-6.6 (i)2.6 (al)2.6 ( s)-2 (u)10.5 (r)4.9 (g)-11.2 (er)-6 (y)8.9 (.)-6.6 ( )11.2 (I)-6.6 (n )]TJ 0 -1.37 Td [(a s)-1.9 (t)-6.7 (udy)8.9 ( o)10.5 (f)-6.6 ( 31)10.5 ( pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( )11.2 (\()-5.9 (1)10.5 (0 pat)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h appar)-6 (en)10.5 (t)-6.6 (l)2.6 (y)8.9 ( s)-2 (por)-6 (adi)2.6 (c)-2 ( di)2.6 (s)-2 (eas)-2 (e,)4.3 ( 15 )]TJ 0 -1.38 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h M)15.8 (E)2 (N)2.6 (2A)1.9 (,)-6.6 ( and 6 pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h M)15.8 (E)-9 (N)2.7 (2B)-8.9 (\))-6 (,)4.3 ( t)-6.6 (he)10.6 ( 5)]TJ 0 Tc 0 Tw (-)Tj 25.261 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td (and 10)Tj 0 Tc 0 Tw 3.043 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(y)8.9 (ear)-6 ( )]TJ 0.007 Tw -28.924 -1.37 Td [(s)-2 (ur)-6 (v)8.9 (i)2.6 (v)8.9 (a)-11.3 (l)2.7 ( r)-5.9 (at)-6.6 (es)8.9 ( w)13.4 (er)-6 (e 90%)-4.3 ( )11.3 (and 86%)6.6 (,)-6.6 ( )11.2 (r)-5.9 (es)-2 (pec)8.9 (t)-6.6 (i)2.6 (v)8.9 (el)-8.2 (y)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 254.04 184.32 Tm [(45)-17 (7)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 265.8 180.36 Tm ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(T)-10.6 (w)13.5 (o s)-2 (t)-6.6 (ud)]TJ [(i)2.6 (es)-2 ( hav)8.9 (e )]TJ -22.217 -1.38 Td [(r)-6 (epor)4.9 (t)-6.6 (ed hi)13.5 (g)-11.3 (her)5 ( m)-6 (o)10.5 (r)-5.9 (t)-6.7 (al)2.6 (i)2.6 (t)-6.6 (y)8.9 ( )11.2 (r)-5.9 (at)-6.7 (es)8.9 ( )11.2 (f)-17.4 (o)10.5 (r)-6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (i)2.6 (t)-6.6 (h hi)2.7 (gh pos)-2 (t)-6.6 (ope)10.5 (r)-6 (at)-6.6 (i)2.6 (v)8.9 (e s)-2 (er)-6 (u)10.5 (m)5 ( )]TJ 0 -1.37 Td [(c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n v)8.9 (al)2.6 (ues)-2 (,)-6.6 ( w)13.4 (i)2.6 (t)-6.6 (h m)4.9 (or)-6 (e )11.2 (t)-6.6 (han 50)10.6 (%)-4.3 ( o)10.6 (f)-6.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( )11.3 (hav)8.9 (i)2.6 (ng)-11.2 ( a r)-5.9 (e)10.5 (c)-2 (ur)4.9 (r)-6 (enc)-2 (e )]TJ -0.004 Tw 0 -1.38 Td [(dur)-6 (i)2.7 (ng )-10.6 (a m)-6 (ean f)-6.7 (ol)2.6 (l)2.6 (ow)]TJ 0 Tc 0 Tw 9.185 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up o)10.5 (f)-17.5 ( 10)10.5 ( y)8.9 (ear)-6 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 201.6 138.72 Tm [(439,)-1.8 (45)-17 (8)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 226.68 134.76 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(R)2.6 (out)-6.6 (i)2.6 (ne l)2.6 (y)8.9 (m)-5.9 (phadenec)-2 (t)-6.6 (om)-6 (y)8.9 ( o)10.5 (r)-6 ( )]TJ -18.685 -1.37 Td [(ex)8.8 (c)-2 (i)2.6 (s)-2 (i)2.7 (on of)-17.5 ( pal)2.6 (pabl)2.6 (e )11.2 (t)-6.6 (um)4.9 (or)-5.9 ( )11.3 (g)-11.3 (ene)10.6 (r)-6 (al)2.6 (l)2.6 (y)8.9 ( f)-17.5 (ai)2.6 (l)2.6 (s)-2 ( )11.3 (t)-6.6 (o no)10.5 (r)-5.9 (m)4.9 (al)2.6 (i)-8.2 (z)8.9 (e t)-6.6 (he)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 25.609 0 Td [(s)-2 (e)10.5 (r)-5.9 (um)4.9 ( c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)13.5 (n )]TJ -25.609 -1.38 Td [(c)-2 (onc)-2 (ent)-6.6 (r)-5.9 (a)10.5 (t)-6.6 (i)2.6 (ons)-2 ( i)2.6 (n )11.3 (s)-2 (uc)-2 (h p)10.5 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 (;)4.3 ( t)4.3 (her)-5.9 (e)10.5 (f)-6.6 (or)-5.9 (e)10.5 (,)-6.6 ( s)-2 (o)10.5 (m)-5.9 (e )11.3 (hav)8.9 (e f)-17.5 (oc)-2 (u)10.5 (s)-2 (ed on)10.5 ( )]TJ 0 -1.37 Td [(det)-6.6 (ec)-1.9 (t)-6.7 (i)2.7 (on an)10.5 (d e)10.5 (r)-5.9 (adi)2.6 (c)-2 (at)-6.6 (i)2.6 (o)10.6 (n o)10.5 (f)-6.6 ( m)-5.9 (i)2.6 (c)8.8 (r)-5.9 (os)-2 (c)-2 (opi)2.7 (c)-2 ( )11.2 (t)-6.6 (um)-6 (o)10.5 (r)-5.9 ( d)10.5 (epos)-2 (i)2.6 (t)-6.6 (s)-2 ( w)13.4 (i)2.6 (t)-6.6 (h a c)-2 (u)10.6 (r)-6 (at)-6.7 (i)2.7 (v)8.8 (e )]TJ 0 -1.38 Td [(i)2.6 (nt)-6.6 (ent)-6.6 ( i)2.6 (n pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (i)2.6 (t)-6.6 (hout)-6.6 ( )11.3 (di)2.6 (s)-2 (t)-6.6 (ant)-6.6 ( )11.3 (m)-6 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (as)8.9 (es)-2 (.)4.2 ( )]TJ -0.011 Tc 0.011 Tw [(E)-7 (xt)-15.6 (e)-9.3 (n)-9.4 (s)-11 (i)-6.4 (ve)]TJ 0 Tc 0 Tw 24.141 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(di)2.6 (s)-2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (on t)-6.6 (o )]TJ -24.424 -1.37 Td [(r)-6 (em)-6 (ov)8.9 (e al)2.6 (l)2.6 ( nodal)2.6 ( and pe)10.5 (r)5 (i)2.6 (nodal)2.6 ( t)-6.6 (i)2.6 (s)-2 (s)-2 (ue )11.3 (f)-6.7 (r)-5.9 (o)10.5 (m)-5.9 ( )11.2 (t)-6.6 (he ne)10.5 (c)-2 (k)-2 ( and )0.5 (uppe)10.5 (r)-5.9 ( )]TJ 0 -1.38 Td [(m)-6 (edi)2.7 (as)-2 (t)-6.6 (i)2.6 (num)4.9 ( w)13.5 (as)-2 ( )11.2 (f)-17.4 (i)2.6 (r)-6 (s)8.9 (t)-6.6 ( )11.3 (r)-6 (e)10.5 (por)-5.9 (t)-6.7 (ed)10.5 ( t)-6.6 (o)10.5 ( nor)5 (m)-6 (al)2.6 (i)2.6 (z)8.8 (e t)-6.6 (he s)8.9 (er)-5.9 (um)4.9 ( c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n l)2.6 (ev)8.9 (el)2.7 (s)-2.1 ( )0.5 (i)2.6 (n )]TJ 34.554 42.598 Td [(4 o)10.5 (f)-6.6 ( 11 pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( at)4.2 ( l)2.6 (eas)-2 (t)4.3 ( )11.3 (2 y)8.9 (ear)-6 (s)-2 ( pos)8.9 (t)-6.6 (oper)-6 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (el)-8.3 (y)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 637.92 517.92 Tm [(4)-17 (59)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 649.56 513.96 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)-6.6 (n s)-2 (ubs)-2 (e)10.6 (q)-11.3 (uen)10.5 (t)-6.6 ( l)2.6 (ar)5 (g)-11.3 (e)10.6 (r)-6 ( )]TJ -22.435 -1.38 Td [(s)-2 (t)-6.6 (udi)2.6 (es)-2 (,)4.2 ( 20%)6.6 ( t)-6.6 (o)10.5 ( 40%)6.6 ( o)10.5 (f)-6.6 ( p)10.5 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( unde)10.5 (r)5 (g)-11.3 (oi)2.6 (n)10.5 (g)-11.2 ( )11.3 (m)-6 (i)2.6 (c)-2 (r)-5.9 (o)10.5 (di)2.6 (s)-2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( t)-6.6 (h)10.5 (e c)-2 (en)10.5 (t)-6.6 (r)-6 (al)2.6 ( )]TJ 0 -1.37 Td [(and bi)2.6 (l)2.6 (at)-6.6 (er)-5.9 (al)2.6 ( nec)8.9 (k)-2 ( c)-2 (o)10.5 (m)-5.9 (pa)10.6 (r)-6 (t)4.3 (m)-6 (ent)-6.6 (s)8.9 ( w)13.5 (er)-6 (e bi)2.7 (oc)-2 (hem)-5.9 (i)2.6 (c)-2 (a)10.5 (l)2.6 (l)-8.3 (y)8.9 ( c)-2 (ur)-6 (ed,)4.3 ( w)13.5 (i)2.6 (t)-6.6 (h m)-5.9 (i)2.6 (ni)2.6 (m)-5.9 (al)2.6 ( )]TJ 0 -1.38 Td [(per)-6 (i)2.7 (oper)-5.9 (at)-6.6 (i)2.6 (v)8.9 (e m)-5.9 (o)10.5 (r)-5.9 (bi)2.6 (di)2.6 (t)-6.6 (y)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 519.36 472.32 Tm [(46)-17 (0,)-1.9 (4)-16.9 (61)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 544.56 468.36 Tm ( )Tj -0.002 Tc 0.007 Tw 0.261 0 Td [(W)-36.3 (hen)10.6 ( r)-6 (epea)10.5 (t)-6.6 ( s)-2 (u)10.5 (r)4.9 (g)-11.2 (er)4.9 (y)8.8 ( i)2.6 (s)-2 ( pl)2.6 (anned )11.2 (f)-17.4 (or)4.9 ( c)-2 (ur)-6 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e )]TJ -12.902 -1.37 Td [(i)2.6 (nt)-6.6 (ent)-6.6 (,)4.2 ( pr)-6 (eope)10.5 (r)-6 (at)-6.6 (i)2.6 (v)8.9 (e as)-2 (s)-2 (e)10.5 (s)-2 (s)-2 (m)-6 (en)10.5 (t)-6.6 ( s)-2 (houl)2.6 (d i)2.6 (nc)-2 (l)2.6 (ude l)2.6 (o)10.5 (c)-2 (or)-5.9 (e)10.5 (g)-11.2 (i)2.6 (onal)2.6 ( i)2.6 (m)-6 (a)10.5 (g)-11.2 (i)2.6 (ng \()-5.9 (i)2.6 (e)10.5 (,)]TJ 0 Tc 0 Tw 31.859 0 Td ( )Tj -0.002 Tc 0.007 Tw -31.859 -1.38 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2 (ono)10.5 (g)-11.2 (r)-6 (aphy)8.8 ( o)10.6 (f)-6.7 ( )11.3 (t)-6.6 (he n)10.5 (ec)-2 (k)-2 ( and upp)10.5 (er)4.9 ( m)-5.9 (edi)2.6 (as)8.9 (t)-6.6 (i)2.6 (num)-5.9 (\))4.9 ( and )0.5 (a)10.5 (t)-6.6 (t)-6.7 (e)10.6 (m)-6 (pt)4.2 (s)-2 ( )11.3 (t)-6.6 (o )]TJ 0 -1.37 Td [(ex)8.8 (c)-2 (l)2.6 (ude pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h di)2.6 (s)-2 (t)4.3 (ant)-6.7 ( )11.3 (m)-5.9 (et)-6.6 (as)8.8 (t)-6.6 (as)-2 (es)8.9 (,)-6.6 ( w)13.5 (hi)2.6 (c)-2 (h m)4.9 (ay)8.8 ( i)2.6 (nc)-2 (l)2.6 (ude )]TJ 0.002 Tw 0 -1.38 Td [(c)-2 (ont)-6.6 (r)-6 (as)8.9 (t)]TJ 0 Tc 0 Tw 3.554 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(enhan)10.5 (c)-2 (ed C)13.5 (T or)4.9 ( M)15.8 (R)2.6 (I)-6.6 ( o)10.5 (f)-17.5 ( )11.3 (t)-6.6 (he nec)8.8 (k)-1.9 (,)4.2 ( c)-2 (hes)-2 (t)4.3 (,)4.2 ( )11.3 (and abdom)-6 (en)10.5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 715.68 411.6 Tm (461)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 727.32 407.64 Tm ( )Tj EMC /H2 <>BDC /TT1 1 Tf 0.009 Tc 0.007 Tw -29.196 -2.391 Td [(P)2.1 (ost)-5.8 (op)11.3 (er)-4.2 (a)10.7 (t)5.1 (i)-6.5 (v)10.6 (e )0.5 (M)5.1 (anage)10.7 (m)-4.2 (en)11.3 (t)-5.8 ( )11.4 (and)11.3 ( )0.6 (S)2 (u)0.5 (r)-4.2 (v)10.7 (ei)4.4 (l)4.4 (l)-6.4 (an)0.5 (ce)]TJ 0 Tc 0 Tw 21.533 0 Td ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.005 Tc 0.01 Tw -21.815 -1.696 Td [(Ca)-3.4 (lc)-5 (it)-9.7 (o)-3.3 (n)-3.4 (in)-3.3 ( is)]TJ 0 Tc 0 Tw 5.37 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(v)8.9 (er)-5.9 (y)8.8 ( us)-2 (ef)-17.4 (ul)13.5 ( )11.3 (f)-6.7 (or)-5.9 ( s)-2 (u)10.5 (r)-6 (v)8.9 (ei)2.7 (l)2.6 (l)2.6 (anc)-2 (e,)-6.6 ( bec)-2 (aus)-2 (e )11.3 (t)-6.7 (hi)2.6 (s)-2 ( hor)4.9 (m)-5.9 (one)10.5 ( i)2.6 (s)-2 ( onl)2.6 (y)8.9 ( )]TJ -5.652 -1.38 Td [(pr)-6 (oduc)-2 (ed i)2.6 (n )11.3 (t)-6.6 (he)10.6 ( par)-6 (a)10.5 (f)-6.6 (ol)2.6 (l)2.6 (i)-8.3 (c)-2 (ul)2.6 (ar)-6 ( c)-2 (el)2.5 (l)2.7 (s)-2 (.)-6.6 ( )11.2 (Thus)-1.9 (,)4.2 ( m)-6 (ea)10.5 (s)-2 (ur)4.9 (em)-5.9 (ent)-6.6 (s)8.8 ( o)10.6 (f)-6.6 ( s)-2 (e)10.5 (r)-6 (um)4.9 ( )]TJ 0 -1.37 Td [(c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n and C)2.6 (E)2 (A)1.9 ( l)2.6 (ev)8.9 (el)-8.3 (s)-2 ( ar)-6 (e)10.6 ( t)-6.6 (he)10.5 ( c)-2 (or)-6 (ne)10.5 (r)-6 (s)8.9 (t)-6.6 (one o)10.5 (f)-6.6 ( )11.2 (pos)-2 (t)-6.7 (oper)-6 (a)10.6 (t)-6.6 (i)2.6 (v)8.8 (e )]TJ 0 -1.38 Td [(as)-2 (s)-2 (es)-2 (s)-2 (m)-5.9 (en)10.5 (t)-6.6 ( )11.3 (f)-6.6 (or)5 ( r)-5.9 (e)10.5 (s)-2 (i)2.6 (dual)2.6 ( di)2.7 (s)-2.1 (eas)-2 (e \()-5.9 (s)-2 (ee)10.5 ( )]TJ /TT2 1 Tf 0.002 Tw [(S)2 (ur)-5.9 (v)-2 (ei)2.5 (l)2.7 (l)2.6 (anc)-2 (e)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.005 Tc 0.01 Tw 22.446 0 Td [(in)-3.3 ( t)-9.6 (h)-3.3 (e)7.5 ( NCCN )]TJ -0.002 Tc 0.002 Tw -22.446 -1.37 Td [(G)-6.6 (ui)2.7 (de)]TJ 0.007 Tw [(l)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (or)5 ( M)15.8 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( )-10.5 ([)4.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d])-6.6 ( C)2.6 (ar)-5.9 (c)-2 (i)2.6 (no)10.6 (m)-6 (a\))4.9 (.)-6.6 ( Fo)10.5 (r)-6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h a )]TJ 0 -1.38 Td [(det)-6.6 (ec)-1.9 (t)-6.7 (abl)2.6 (e b)10.5 (as)-2 (al)2.7 ( c)-2.1 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (on)10.5 (i)2.6 (n or)-6 ( )0.5 (el)2.6 (ev)8.8 (at)-6.6 (ed C)2.6 (E)2 (A)1.9 ( l)2.6 (ev)8.8 (el)2.6 (,)-6.6 ( nec)8.9 (k)-12.9 ( ul)13.5 (t)-6.6 (r)-5.9 (as)-2 (ound)10.5 ( i)2.6 (s)-2 ( )]TJ 0 -1.37 Td [(r)-6 (ec)-2 (om)5 (m)-6 (ended)10.6 (.)-6.7 ( P)2 (at)-6.7 (i)2.7 (en)10.5 (t)-6.6 (s)-2 ( )11.3 (w)2.6 (i)2.6 (t)-6.6 (h undet)-6.6 (ec)8.9 (t)-6.6 (abl)2.6 (e c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (o)10.5 (ni)2.6 (n l)2.6 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(g)-11.2 ( )11.2 (m)-5.9 (ay)8.9 ( be appr)-6 (o)10.5 (pr)-6 (i)2.7 (at)-6.6 (e.)4.2 ( )]TJ 0 Tc 0 Tw 12.402 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -13.739 -2.37 Td [(P)2 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h det)-6.6 (e)10.6 (c)-2 (t)-6.6 (abl)2.6 (e )11.3 (s)-2 (er)-5.9 (um)4.9 ( m)-5.9 (a)10.5 (r)4.9 (k)-12.8 (e)10.5 (r)-6 (s)-2 ( )11.3 (\()-6 (i)2.7 (e,)-6.6 ( )11.3 (c)-2 (al)2.6 (c)-2 (i)2.6 (t)4.3 (oni)2.6 (n l)2.6 (ev)8.9 (el)2.7 (s)-2 ( )]TJ /C2_0 1 Tf 0 Tc 0 Tw <0095>Tj /TT0 1 Tf -0.002 Tc 0.007 Tw 27.185 0 Td [(150 p)10.5 (g)-11.2 (/)4.2 (m)-5.9 (L\))4.9 ( )]TJ -27.185 -1.37 Td [(s)-2 (houl)2.7 (d hav)8.9 (e c)-2 (ont)-6.5 (r)-6 (a)10.5 (s)-2 (t)]TJ 0 Tc 0 Tw 9.196 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(en)10.5 (hanc)-2 (ed )-10.6 (C)13.5 (T)-10.5 ( \()]TJ 0 Tc 0 Tw 6.587 0 Td Tj -0.002 Tc 0.007 Tw 0.554 0 Td [(P)2 (E)12.8 (T)-10.6 (\))4.9 ( or)4.9 ( M)15.8 (R)2.6 (I)-6.6 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.6 ( nec)8.8 (k)-2 (,)-6.6 ( )11.3 (c)-2 (hes)-2 (t)4.3 (,)-6.6 ( an)10.5 (d )]TJ -16.674 -1.38 Td [(abdom)-5.9 (en w)13.4 (i)2.6 (t)-6.6 (h a l)2.7 (i)2.6 (v)8.8 (er)-6 ( pr)-6 (o)10.5 (t)-6.6 (oc)-2 (ol)2.6 (.)-6.7 ( B)2 (one)10.5 ( s)-2 (c)-2 (an)10.5 ( and M)15.7 (R)2.6 (I)-6.6 ( o)10.6 (f)-6.7 ( )0.5 (ax)8.9 (i)2.6 (al)2.6 ( )0.5 (s)-2.1 (k)-12.8 (el)2.6 (et)-6.6 (on)10.6 ( s)-2 (houl)13.5 (d )]TJ 0 -1.37 Td [(be c)-2 (ons)-2 (i)2.6 (d)]TJ [(er)-5.9 (ed)10.6 ( i)2.7 (n s)-2 (el)2.6 (ec)-2 (t)4.3 ( p)10.5 (at)-6.6 (i)2.7 (ent)-6.6 (s)-2 ( )11.2 (s)-2 (uc)-2 (h as)8.9 ( )11.2 (t)-6.6 (hos)-2 (e w)13.4 (i)2.7 (t)-6.7 (h v)8.9 (er)-5.9 (y)8.8 ( el)2.6 (ev)8.9 (at)-6.6 (ed )]TJ 0 -1.38 Td [(c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n l)2.7 (ev)8.9 (el)2.6 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 485.04 51.84 Tm [(41)-17 (3,)-1.9 (4)-16.9 (14)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 510.24 47.88 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (he N)2.7 (C)2.6 (C)2.6 (N)2.6 ( P)1.9 (anel)2.6 ( r)-5.9 (ec)-2 (o)10.5 (g)-11.2 (ni)2.7 (z)8.8 (es)-2 ( t)-6.6 (ha)]TJ -0.004 Tw 14.467 0 Td [(t)-6.6 ( m)-6 (any)8.9 ( )-10.6 (di)13.5 (f)-6.6 (f)-17.5 (e)10.6 (r)-6 (ent)4.2 ( )]TJ EMC ET endstream endobj 866 0 obj 25316 endobj %% Contents for page 96 %% Original object ID: 193 0 867 0 obj << /Length 868 0 R >> stream Q q BT /Xi94 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 868 0 obj 245 endobj %% Contents for page 97 %% Original object ID: 194 0 869 0 obj << /Length 870 0 R >> stream q endstream endobj 870 0 obj 2 endobj %% Contents for page 97 %% Original object ID: 11436 0 871 0 obj << /Length 872 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (34)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(i)2.6 (m)-5.9 (ag)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( m)-6 (odal)2.6 (i)2.6 (t)-6.6 (i)2.6 (es)-2 ( m)-5.9 (ay)8.9 ( be )-10.6 (us)-2 (ed t)-6.6 (o )-10.6 (ex)8.8 (am)-6 (i)2.7 (ne f)-6.6 (or)4.9 ( )-10.6 (r)4.9 (es)-2 (i)2.6 (dual)2.6 ( )-10.6 (or)-6 ( m)-6 (et)-6.6 (as)8.9 (t)-6.6 (at)-6.6 (i)2.6 (c)8.9 ( )]TJ 0.007 Tw 0 -1.38 Td [(t)-6.6 (um)-5.9 (o)10.5 (r)-5.9 (,)4.2 ( but)4.3 ( t)-6.6 (he)10.6 (r)-6 (e i)2.7 (s)8.8 ( i)2.6 (ns)-2 (u)10.5 (f)-6.6 (f)-17.5 (i)13.5 (c)-2 (i)2.6 (ent)-6.6 ( ev)8.8 (i)2.6 (denc)-2 (e t)-6.7 (o)10.6 ( r)-6 (ec)-2 (o)10.5 (m)4.9 (m)-6 (end any)8.9 ( par)4.9 (t)-6.6 (i)2.6 (c)-2 (ul)2.7 (ar)-5.9 ( )]TJ 0 -1.37 Td [(c)-2 (hoi)2.6 (c)-2 (e or)4.9 ( )]TJ -0.004 Tw [(c)-2 (om)-6 (bi)2.6 (na)10.6 (t)-6.6 (i)2.6 (on )-10.6 (o)10.5 (f)-6.6 ( t)-6.6 (es)-2 (t)-6.6 (s)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 172.2 487.56 Tm [(413,)-1.8 (4)-17 (14)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 197.28 483.6 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -16.022 -2.38 Td [(For)-6 ( )11.3 (t)-6.6 (he as)-2 (y)8.9 (m)-6 (p)10.6 (t)-6.6 (om)-6 (a)10.6 (t)-6.6 (i)2.6 (c)-2 ( pa)10.6 (t)-6.7 (i)2.6 (ent)-6.6 ( )0.5 (w)13.4 (i)2.6 (t)-6.6 (h det)-6.6 (ec)8.9 (t)-6.6 (abl)2.6 (e )11.2 (m)-5.9 (ar)]TJ 21.772 0 Td [(k)-12.9 (e)10.6 (r)-6 (s)-2 ( i)2.6 (n)10.5 ( w)13.5 (hom)-5.9 ( i)2.7 (m)-6 (a)10.5 (g)-11.2 (i)2.6 (ng )]TJ -21.772 -1.37 Td [(f)-6.6 (ai)2.7 (l)2.6 (s)-2 ( t)-6.7 (o)10.6 ( i)2.6 (dent)-6.6 (i)13.5 (f)-17.5 (y)8.9 ( )11.3 (f)-17.5 (oc)-1.9 (i)13.4 ( o)10.6 (f)-6.7 ( di)2.6 (s)-2 (eas)-2 (e,)-6.6 ( )11.2 (t)-6.6 (he N)2.6 (C)2.6 (C)2.6 (N)2.6 ( )0.5 (P)1.9 (anel)2.6 ( )11.3 (r)4.9 (ec)-2 (om)-6 (m)-5.9 (en)10.5 (ds)-2 ( c)-2 (on)10.6 (s)-2 (er)-5.9 (v)8.8 (at)-6.6 (i)2.6 (v)8.9 (e )]TJ 0 -1.38 Td [(s)-2 (ur)-6 (v)8.9 (ei)2.6 (l)2.6 (l)2.7 (anc)-2 (e )-10.5 (w)13.5 (i)2.6 (t)-6.6 (h r)-6 (epeat)4.3 ( )11.3 (m)-6 (eas)-2 (ur)-6 (e)10.5 (m)-5.9 (en)10.5 (t)-6.6 ( o)10.6 (f)-6.6 ( )11.2 (t)-6.6 (he s)-2 (e)10.5 (r)-5.9 (u)10.5 (m)-5.9 ( )11.2 (m)-5.9 (ar)4.9 (k)-12.8 (e)10.5 (r)-6 (s)8.9 ( ev)8.9 (er)-6 (y)8.9 ( 6 t)-6.6 (o)10.5 ( 12 )]TJ 0 -1.37 Td [(m)-6 (ont)-6.6 (hs)8.9 (.)-6.6 ( Fo)10.5 (r)-6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (ho ar)-6 (e)10.6 ( as)-2 (y)8.9 (m)-6 (pt)-6.6 (o)10.5 (m)-5.9 (at)-6.6 (i)2.6 (c)8.9 ( w)13.4 (i)2.7 (t)-6.7 (h abnor)-5.9 (m)-6 (al)2.6 ( )11.2 (m)-5.9 (ar)5 (k)-2.1 (er)-6 (s)8.9 ( and )]TJ 0 -1.38 Td [(r)-6 (epeat)-6.7 (ed)10.5 ( ne)10.5 (g)-11.2 (at)-6.6 (i)2.6 (v)8.9 (e i)2.6 (m)-6 (a)]TJ 9.859 0 Td [(g)-11.2 (i)2.6 (ng,)-6.6 ( c)-2 (on)10.6 (t)-6.6 (i)2.6 (nued ac)8.9 (t)-6.6 (i)2.6 (v)8.9 (e s)-2 (ur)-6 (v)8.9 (ei)2.6 (l)2.6 (l)2.6 (anc)-2 (e or)-6 ( c)-2 (ons)-2 (i)2.6 (der)-6 (a)10.5 (t)-6.6 (i)2.6 (on )]TJ -9.859 -1.37 Td [(o)10.5 (f)-17.5 ( c)-2 (e)10.6 (r)-6 (v)8.9 (i)2.6 (c)-2 (al)2.7 ( r)-6 (eoper)-6 (at)-6.6 (i)2.6 (on)10.5 ( i)2.6 (s)-2 ( )11.2 (r)-5.9 (ec)-2 (om)4.9 (m)-5.9 (ended)10.5 ( i)13.5 (f)-17.5 ( p)10.5 (r)-5.9 (i)2.6 (m)-6 (ar)-6 (y)8.9 ( )11.3 (s)-2 (ur)4.9 (g)-11.2 (er)-6 (y)8.9 ( w)13.5 (as)-2 ( i)2.6 (nc)-2 (om)-5.9 (pl)2.6 (et)-6.6 (e)10.5 (.)-6.6 ( )]TJ -0.004 Tw 0 -1.38 Td [(For)-6 ( t)-6.6 (he )-10.6 (pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 ( )-10.6 (w)13.5 (i)2.6 (t)-6.6 (h )-10.6 (i)2.6 (nc)-2 (r)-5.9 (e)10.5 (as)-2.1 (i)2.7 (ng)-11.2 ( s)-2 (er)-5.9 (u)10.5 (m)-6 ( m)-6 (ar)4.9 (k)-2 (er)-5.9 (s)8.9 (,)-6.6 ( m)4.9 (or)-6 (e f)-6.6 (r)-6 (e)10.5 (q)-11.2 (uen)10.5 (t)-6.6 ( )-10.6 (i)2.6 (m)-5.9 (a)10.5 (g)-11.2 (i)2.6 (n)10.5 (g )-10.6 (m)-6 (a)10.5 (y)8.9 ( )]TJ 0.007 Tw 0 -1.37 Td [(be c)-2 (ons)-2 (i)2.6 (der)-5.9 (ed)10.6 (.)-6.7 ( )11.3 (O)-6.6 (ut)4.2 (s)-2 (i)2.6 (de o)10.5 (f)-6.6 ( c)-2 (l)2.6 (i)2.7 (ni)2.6 (c)-2 (al)2.6 ( t)-6.6 (r)-6 (i)2.6 (al)2.6 (s)-2 (,)4.3 ( no)10.5 ( t)-6.6 (he)10.5 (r)-6 (ap)10.5 (eut)-6.6 (i)]TJ 23.37 0 Td [(c)-2 ( i)2.6 (nt)-6.6 (e)10.5 (r)-6 (v)8.9 (ent)-6.6 (i)2.6 (on i)2.6 (s)-2 ( )]TJ -23.37 -1.38 Td [(r)-6 (ec)-2 (om)5 (m)-6 (ended)10.5 ( on )11.3 (t)-6.6 (he ba)10.5 (s)-2 (i)2.6 (s)-2 ( o)10.5 (f)-6.6 ( abnor)4.9 (m)-5.9 (al)2.6 ( )11.3 (m)-5.9 (ar)4.9 (k)-12.9 (e)10.6 (r)-6 (s)-2 ( )11.3 (al)2.6 (one.)-6.6 ( )]TJ 0 Tc 0 Tw 24.707 0 Td ( )Tj EMC /H2 <>BDC /TT1 1 Tf 0.009 Tc 0.007 Tw -24.707 -2.391 Td [(R)2.7 (ecur)-4.1 (r)6.7 (ent)5 ( )0.6 (o)11.3 (r)6.7 ( )0.5 (P)2.1 (er)-4.2 (s)10.7 (i)-6.5 (s)10.6 (t)-5.8 (en)11.3 (t)-5.8 ( )0.5 (D)13.6 (i)-6.5 (se)10.7 (ase)10.6 ( )]TJ 0 Tc 0 Tw 15.685 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw -15.685 -1.696 Td [(K)2 (i)2.6 (nas)-2 (e i)2.6 (nhi)2.7 (bi)2.6 (t)-6.6 (or)-6 (s)-2 ( )11.3 (m)-6 (ay)8.8 ( be appr)-6 (op)10.5 (r)-5.9 (i)2.6 (at)-6.6 (e )11.2 (f)-6.6 (or)4.9 ( s)-2 (el)2.7 (ec)-2 (t)4.3 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.7 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h r)-6 (e)10.5 (c)-1.9 (ur)4.9 (r)-5.9 (ent)4.2 ( or)4.9 ( )]TJ 0 -1.38 Td [(per)-6 (s)-2 (i)2.7 (s)-2 (t)-6.6 (en)10.5 (t)-6.6 ( M)15.8 (T)-10.6 (C)2.7 ( )11.2 (t)-6.6 (hat)4.3 ( i)2.6 (s)-2 ( no)10.5 (t)-6.6 ( )11.3 (r)-5.9 (es)-2 (ec)-2 (t)-6.6 (abl)2.6 (e)10.5 ( \()-6 (s)-2 (ee)10.5 ( )]TJ /TT2 1 Tf [(R)2.6 (ec)-2 (ur)4.9 (r)5 (ent)-6.6 ( o)10.5 (r)-6 ( P)2 (er)4.9 (s)-2 (i)2.6 (s)-2 (t)-6.6 (ent)4.3 ( D)2.6 (i)2.6 (s)-2 (eas)8.9 (e)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 0 -1.37 Td [(i)2.6 (n t)-6.6 (he N)2.6 (C)2.6 (C)2.6 (N)2.6 ( )11.2 (G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( f)-6.6 (or)4.9 ( M)15.8 (edul)-8.2 (l)2.6 (ar)-6 (y)8.9 ( [)-6.7 (T)-10.5 (hy)8.9 (r)-5.9 (oi)2.6 (d])4.2 ( C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-6 (a\))5 (.)-6.6 ( A)1.9 (l)13.5 (t)-6.6 (hou)10.5 (g)-11.2 (h )]TJ 0 -1.38 Td [(k)-12.9 (i)2.6 (nas)-1.9 (e)10.5 ( i)2.6 (nhi)2.6 (bi)2.7 (t)-6.6 (or)-6 (s)-2 ( )11.3 (m)-5.9 (ay)8.9 ( be )11.3 (r)-6 (ec)-2 (om)4.9 (m)-5.9 (ended)10.5 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( pa)10.5 (t)-6.6 (i)2.6 (ent)4.3 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h M)15.8 (T)-10.6 (C)2.6 (,)-6.6 ( i)2.6 (t)-6.6 ( i)2.6 (s)8.9 ( )]TJ 0 -1.37 Td [(i)2.6 (m)-5.9 (por)-5.9 (t)-6.6 (an)10.6 (t)-6.6 ( )11.2 (t)-6.6 (o no)10.5 (t)-6.6 (e)10.6 ( t)-6.7 (ha)10.5 (t)-6.6 ( )11.3 (k)-12.9 (i)2.6 (n)10.6 (as)-2 (e i)2.7 (nhi)2.6 (bi)2.6 (t)-6.6 (or)-6 (s)-2 ( )11.3 (m)-6 (ay)8.9 ( not)4.2 ( be)10.5 ( appr)-6 (op)10.5 (r)-6 (i)2.6 (at)-6.6 (e )11.3 (f)-6.6 (or)4.9 ( pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 (s)-2 ( )]TJ 0 -1.37 Td [(w)2.6 (i)2.6 (t)-6.6 (h s)-2 (t)-6.7 (abl)2.7 (e o)10.5 (r)-5.9 ( )11.2 (s)-2 (l)2.7 (ow)13.5 (l)-8.3 (y)8.9 ( pr)-6 (og)-11.2 (r)5 (es)-2 (s)-2 (i)2.6 (v)8.9 (e i)2.6 (ndol)2.6 (ent)-6.6 ( d)]TJ 0.002 Tw [(i)2.6 (s)-2 (eas)8.8 (e.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 266.88 218.88 Tm [(329,)-1.8 (4)-17 (62)-17 (,)-1.8 (46)-17 (3)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 305.64 214.92 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(V)2 (andet)-6.6 (ani)2.6 (b and )]TJ -25.837 -1.38 Td [(c)-2 (aboz)8.9 (ant)-6.6 (i)2.6 (ni)2.6 (b ar)-5.9 (e or)-6 (al)2.7 ( )11.2 (r)-5.9 (ec)8.9 (ept)-6.6 (or)5 ( )11.2 (k)-12.9 (i)2.7 (nas)-2 (e i)2.6 (nhi)2.7 (bi)2.6 (t)-6.6 (or)-6 (s)8.9 ( t)-6.6 (h)10.5 (at)-6.6 ( i)2.6 (nc)-2 (r)-6 (ea)10.5 (s)-2 (e P)1.9 (FS)2 ( i)2.6 (n)10.5 ( )]TJ 0 Tc 0 Tw 0 -1.37 Td (p)Tj -0.002 Tc -0.004 Tw 0.554 0 Td [(at)-6.7 (i)2.7 (ent)-6.6 (s)-2 ( )-10.7 (w)13.5 (i)2.6 (t)-6.6 (h m)-6 (et)-6.6 (as)8.9 (t)-6.6 (at)-6.6 (i)2.6 (c)8.9 ( M)15.8 (T)-10.5 (C)]TJ 0 Tc 0 Tw 12.228 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 167.76 188.52 Tm [(444)-16.9 (,)-1.9 (44)-17 (7,)-19.1 (464)]TJ 0 Tc 0 Tw 5.586 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.328 0 Td [(4)-17 (66)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 220.56 184.56 Tm ( )Tj 0.293 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.002 Tw -18.141 -2.38 Td [(V)2 (andet)-6.6 (ani)2.6 (b )]TJ 0.007 Tw 5.326 0 Td [(i)2.6 (s)-2 ( a)10.5 ( m)-5.9 (ul)2.6 (t)-6.6 (i)13.5 (t)-6.6 (ar)5 (get)-6.6 (ed )11.2 (k)-12.8 (i)2.6 (nas)-2 (e)10.5 ( i)2.6 (nhi)2.6 (bi)2.6 (t)-6.6 (or)-5.9 (;)4.2 ( i)2.6 (t)-6.6 ( i)2.6 (n)10.6 (hi)2.6 (bi)2.6 (t)-6.6 (s)-2 ( R)2.6 (E)2 (T,)-6.7 ( v)8.9 (as)-2 (c)-2 (ul)2.6 (ar)-6 ( )]TJ -5.326 -1.37 Td [(endot)-6.6 (hel)2.6 (i)2.6 (al)2.6 ( gr)-5.9 (ow)13.5 (t)-6.6 (h )11.2 (f)-17.5 (ac)8.9 (t)-6.6 (or)4.9 ( r)-5.9 (ec)-2 (ep)10.5 (t)-6.6 (or)4.9 ( \()-6 (V)2 (E)12.8 (G)-6.6 (FR)2.6 (\))-6 (,)4.3 ( and)10.5 ( )11.3 (endot)-6.6 (hel)2.6 (i)2.6 (al)2.6 ( gr)-5.9 (ow)13.5 (t)-6.6 (h )11.2 (f)-17.5 (ac)8.9 (t)-6.6 (or)4.9 ( )]TJ -0.004 Tw 0 -1.38 Td [(r)-6 (ec)-2 (ept)-6.6 (o)10.5 (r)-5.9 ( \()-5.9 (E)1.9 (G)-6.6 (FR)13.5 (\))-6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 108 131.88 Tm (444)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 119.52 127.92 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)-6.6 (n a)10.6 ( )11.2 (phas)-2 (e I)4.3 (I)-6.6 (I)4.3 ( r)-6 (ando)10.5 (m)-6 (i)2.6 (z)8.9 (ed t)-6.6 (r)-5.9 (i)2.6 (a)10.5 (l)2.6 ( i)2.6 (n )]TJ [(pat)-6.7 (i)2.6 (ent)-6.7 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ -8.978 -1.37 Td [(unr)-6 (es)-2 (ec)-2 (t)-6.6 (abl)2.6 (e)10.5 (,)-6.6 ( l)2.6 (oc)-2 (al)2.6 (l)2.6 (y)8.9 ( adv)-2 (anc)-2 (ed,)-6.6 ( o)10.5 (r)-5.9 ( )11.2 (m)-5.9 (et)-6.6 (a)10.5 (s)-2 (t)-6.6 (a)10.6 (t)-6.7 (i)2.7 (c)-2 ( M)15.7 (TC)2.5 ( )0.5 (\()-6 (n )11.3 (=)-4.9 ( 331)10.5 (\))-6 (,)4.3 ( v)8.9 (andet)-6.6 (ani)2.6 (b )]TJ 0.002 Tw 0 -1.38 Td [(i)2.6 (nc)-2 (r)-6 (eas)-2 (ed )]TJ -0.004 Tc 0.004 Tw 4.609 0 Td [(PF)-1.7 (S)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 2.217 0 Td [(w)13.5 (hen c)-2 (o)10.6 (m)-6 (par)-5.9 (ed)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h pl)2.6 (ac)-2 (ebo \()]TJ 13.511 0 Td [(H)13.5 (R)2.6 (,)-6.6 ( 0.)-6.6 (46)10.5 (;)-6.6 ( )11.3 (95%)6.5 ( C)2.6 (I)]TJ -0.013 Tc 0.018 Tw 7.75 0 Td [(,)-6.7 ( 0)-11.4 (.)-17.6 (31)]TJ 0 Tc 0 Tw 2.489 0 Td <96>Tj -0.002 Tc 0.002 Tw -30.576 -1.37 Td [(0.)-6.7 (69;)4.3 ( )]TJ /TT2 1 Tf 0 Tc 0 Tw 2.5 0 Td (P)Tj 0.663 0 Td ( )Tj /TT0 1 Tf -0.002 Tc -0.004 Tw 0.283 0 Td [(<)5.9 ( .)-6.6 (001)]TJ -0.007 Tc 0.007 Tw [(\);)-11.6 ( )]TJ -0.002 Tc 3.685 0 Td [(ov)8.8 (er)-6 (al)2.6 (l)2.6 ( s)8.8 (ur)-5.9 (v)8.8 (i)-8.2 (v)8.8 (al)2.6 ( dat)-6.6 (a ar)-6 (e)10.6 ( not)4.2 ( y)8.9 (et)-6.7 ( a)10.6 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 303.84 86.4 Tm [(44)-17 (4)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 315.48 82.44 Tm ( )Tj 0.009 Tc -0.009 Tw 0.283 0 Td (Th)Tj -0.002 Tc 0.007 Tw 1.174 0 Td [(e FD)2.6 (A)12.8 ( )]TJ -27.902 -1.38 Td [(appr)-6 (ov)8.8 (ed t)-6.6 (he u)10.6 (s)-2 (e o)10.5 (f)-6.6 ( v)8.9 (andet)-6.6 (ani)2.6 (b )11.2 (f)-17.5 (o)10.6 (r)-6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h l)2.6 (o)]TJ [(c)-2 (al)2.6 (l)2.6 (y)8.9 ( ad)-11.2 (v)8.9 (anc)-2 (ed or)-6 ( )]TJ 0 -1.37 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (at)-6.7 (i)2.7 (c)8.8 ( M)15.8 (T)-10.5 (C)2.6 ( w)13.4 (ho ar)-6 (e )11.2 (not)-6.7 ( )0.5 (el)2.6 (i)2.6 (g)-11.2 (i)2.6 (bl)2.6 (e )11.3 (f)-6.6 (or)5 ( s)-2.1 (ur)4.9 (g)-11.2 (e)10.5 (r)-5.9 (y)8.8 ( a)10.6 (nd w)13.4 (hos)-2 (e di)2.7 (s)-2 (eas)-2 (e i)2.6 (s)-2 ( )]TJ 34.554 41.837 Td [(c)-2 (aus)-2 (i)2.6 (ng s)-2 (y)8.9 (m)-6 (pt)-6.6 (o)10.5 (m)-5.9 (s)-2.1 ( o)10.6 (r)-6 ( )11.3 (gr)4.9 (ow)2.6 (i)2.6 (ng)-11.2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 553.68 517.92 Tm (445)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 565.2 513.96 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(H)2.6 (ow)13.4 (e)-11.2 (v)8.9 (er)-6 (,)-6.6 ( ac)-2 (c)-1.9 (e)10.5 (s)-2 (s)-2 ( i)2.6 (s)-2 ( )11.2 (r)-5.9 (es)-2 (t)4.3 (r)-5.9 (i)2.6 (c)-2 (t)-6.6 (ed)10.5 ( t)-6.6 (h)10.5 (r)-5.9 (ou)10.6 (g)-11.3 (h a)10.5 ( )]TJ -14.793 -1.38 Td [(v)8.9 (andet)-6.6 (ani)2.6 (b R)2.7 (i)2.6 (s)-2 (k)-12.9 ( E)1.9 (v)8.9 (al)2.6 (uat)-6.6 (i)2.6 (on and M)15.8 (i)2.6 (t)-6.6 (i)2.6 (g)-11.2 (at)-6.6 (i)2.6 (on S)12.8 (t)-6.6 (r)-5.9 (a)10.5 (t)-6.6 (e)10.5 (gy)8.9 ( \()-5.9 (R)2.6 (E)-8.9 (M)15.7 (S)2 (\))-5.9 ( pr)-6 (o)10.5 (g)-11.2 (r)-5.9 (a)10.5 (m)-5.9 ( )]TJ 0 -1.37 Td [(bec)-2 (aus)-2 (e o)10.5 (f)-6.6 ( po)10.6 (t)-6.7 (ent)-6.6 (i)2.6 (al)2.6 ( c)-2 (a)10.5 (r)4.9 (di)2.6 (ac)-2 ( t)-6.6 (ox)8.9 (i)2.6 (c)-2 (i)2.6 (t)-6.6 (y)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 581.64 487.56 Tm [(46)-17 (7)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 593.28 483.6 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (he N)2.7 (C)2.6 (C)13.4 (N)2.7 ( P)1.9 (anel)2.6 ( r)-6 (ec)-2 (o)10.5 (m)-6 (m)-5.9 (end)10.5 (s)-2 ( )]TJ -17.337 -1.38 Td [(v)8.9 (andet)-6.6 (ani)2.6 (b \()-5.9 (c)-2 (at)-6.6 (e)10.5 (g)-11.2 (o)10.6 (r)-6 (y)8.9 ( 1\))-5.9 ( )11.2 (f)4.3 (or)-5.9 ( pa)10.6 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.4 (i)2.6 (t)-6.6 (h r)-6 (e)10.6 (c)-2 (ur)4.9 (r)-5.9 (ent)4.2 ( or)4.9 ( per)-5.9 (s)-2 (i)2.6 (s)8.8 (t)-6.6 (ent)4.3 ( M)15.8 (T)-10.6 (C)2.6 ( \()-5.9 (s)-2 (ee)10.5 ( )]TJ /TT2 1 Tf 0 -1.37 Td [(R)2.6 (ec)-2 (ur)-5.9 (r)-6 (ent)4.3 ( o)10.5 (r)-6 ( P)2 (er)5 (s)-2 (i)2.6 (s)-2 (t)-6.6 (ent)4.2 ( )11.3 (D)2.6 (i)2.6 (s)-2 (eas)-2 (e)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.005 Tc 0.01 Tw 14.402 0 Td [(in)-3.3 ( t)-9.6 (h)-3.3 (e)7.5 ( NCCN G)-9.6 (u)7.5 (id)-3.4 (e)-3.3 (lin)-3.4 (e)-3.3 (s)-5 ( f)-20.4 (o)7.5 (r)-9 ( M)12.8 (e)-3.4 (d)-3.3 (u)-3.4 (lla)-3.3 (r)-9 (y)5.9 ( )]TJ -0.002 Tc 0.007 Tw -14.402 -1.38 Td [([)4.3 (T)-10.6 (hy)8.9 (r)-5.9 (oi)2.6 (d])-6.6 ( C)2.6 (ar)-5.9 (c)-2 (i)2.6 (no)10.6 (m)-6 (a\))4.9 (.)]TJ 0 Tc 0 Tw 9.576 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -9.576 -2.37 Td [(C)2.6 (aboz)8.9 (ant)-6.6 (i)2.7 (ni)2.6 (b i)2.6 (s)-2 ( a m)-5.9 (ul)2.6 (t)-6.6 (i)2.6 (t)-6.6 (a)10.6 (r)-6 (get)-6.6 (ed)10.6 ( )11.2 (k)-12.8 (i)2.6 (nas)-2 (e i)2.6 (nhi)2.7 (bi)2.6 (t)-6.6 (or)4.9 ( )]TJ -0.005 Tc 0.01 Tw [(t)-9.6 (h)7.5 (a)-3.4 (t)-9.6 ( in)-3.3 (h)-3.4 (ib)-3.4 (it)-9.6 (s)-5 ( RE)9.8 (T)-13.5 (,)1.2 ( )]TJ -0.002 Tc 0.007 Tw 0 -1.38 Td [(V)2 (E)1.9 (G)-6.6 (FR)2.6 (2,)-6.6 ( and)10.5 ( M)15.8 (E)1.9 (T)-10.5 (.)-6.6 ( )11.2 (I)-6.6 (n a)10.5 ( )11.3 (phas)-2 (e 3 )11.3 (r)-6 (andom)-5.9 (i)2.6 (z)8.9 (ed t)4.2 (r)-5.9 (i)2.6 (al)]TJ 0 Tc 0 Tw 21.989 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(\()-6 (E)12.9 (X)-8.9 (A)1.9 (M)15.8 (\))-6 ( i)2.7 (n pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ -22.272 -1.37 Td [(l)2.6 (oc)-2 (al)2.6 (l)-8.2 (y)8.8 ( adv)8.9 (anc)-2 (ed or)-6 ( m)-5.9 (e)10.5 (t)-6.6 (a)10.5 (s)-2 (t)-6.6 (at)-6.7 (i)2.7 (c)8.8 ( M)15.8 (T)-10.6 (C)2.6 ( )0.5 (\()-6 (n)10.5 ( =)5.9 ( 330\))4.9 (,)-6.6 ( c)-2 (a)10.5 (boz)8.9 (ant)-6.6 (i)2.6 (ni)2.7 (b i)2.6 (nc)-2 (r)-6 (eas)-2 (ed )]TJ 0 -1.38 Td [(m)-6 (edi)2.7 (an P)1.9 (FS)2 ( w)13.5 (hen c)-2 (om)-6 (p)10.5 (ar)-6 (ed w)13.5 (i)2.6 (t)-6.6 (h pl)2.6 (ac)-2 (ebo \()-5.9 (11)10.5 (.)-6.6 (2)10.5 ( )11.2 (v)8.9 (s)-2 (.)-6.6 ( 4.)-6.6 (0 )11.3 (m)-6 (on)10.5 (t)-6.6 (hs)-2 (;)4.3 ( H)2.6 (R)2.6 (,)4.3 ( 0.)-6.6 (28)10.5 (;)-6.6 ( )]TJ 0 -1.37 Td [(95%)-4.3 ( C)2.6 (I)4.3 (,)-6.6 ( 0)10.5 (.)-6.6 (19)]TJ 0 Tc 0 Tw <96>Tj -0.002 Tc 0.002 Tw 6.326 0 Td [(0)10.5 (.)-6.6 (40;)4.3 ( )]TJ /TT2 1 Tf 0 Tc 0 Tw 2.489 0 Td (P)Tj 0.663 0 Td ( )Tj /TT0 1 Tf -0.002 Tc -0.004 Tw 0.272 0 Td [(<)-5 ( .)4.3 (001)]TJ 0.004 Tc (\).)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 550.32 355.08 Tm (447)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 561.84 351.12 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(Fol)2.6 (l)2.6 (o)-11.2 (w)13.5 (i)2.6 (ng)-11.2 ( l)2.6 (ong)]TJ 0 Tc 0 Tw (-)Tj -0.007 Tc 0.001 Tw 6.707 0 Td [(t)-0.7 (e)-5.4 (r)-11 (m f)]TJ -0.005 Tc 0.005 Tw 2.554 0 Td [(o)-3.3 (llo)-3.4 (w)]TJ 0 Tc 0 Tw 2.25 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up,)-6.6 ( t)-6.6 (he)10.6 ( )]TJ -26.337 -1.38 Td [(m)-6 (edi)2.7 (an ov)8.9 (er)-5.9 (al)2.7 (l)2.6 ( s)-2 (ur)-6 (v)8.9 (i)2.6 (v)8.9 (al)2.6 ( f)-6.6 (or)-6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( )11.3 (t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (ed)10.5 ( w)13.4 (i)2.7 (t)-6.7 (h c)-2 (aboz)8.8 (ant)-6.6 (i)2.6 (ni)2.6 (b )-10.4 (w)13.5 (as)-2 ( 26.)-6.6 (6 )]TJ 0 -1.37 Td [(m)-6 (ont)-6.6 (hs)8.9 ( c)-2 (o)10.5 (m)-6 (par)-5.9 (ed)10.6 ( t)-6.7 (o)10.6 ( 21.)4.2 (1 m)-6 (on)10.5 (t)-6.6 (hs)-2 ( )11.3 (f)-6.6 (or)4.9 ( pl)2.6 (ac)-2 (ebo,)4.3 ( al)2.6 (t)4.2 (houg)-11.2 (h)10.5 ( t)-6.6 (hi)2.6 (s)-2 ( )0.5 (di)13.5 (f)-6.6 (f)-6.6 (e)10.5 (r)-6 (enc)-2 (e )]TJ 0 -1.38 Td [(w)13.5 (as)-2 ( not)-6.6 ( s)-2 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (s)-2 (t)-6.6 (i)2.7 (c)-2 (al)2.6 (l)2.6 (y)8.9 ( s)-2 (i)2.6 (g)-11.2 (ni)2.6 (f)-17.4 (i)2.6 (c)-2 (an)10.6 (t)-6.7 ( )11.3 (\()-6 (s)8.9 (t)-6.6 (r)-5.9 (a)10.5 (t)-6.6 (i)13.5 (f)-17.5 (i)2.6 (ed H)2.6 (R)2.6 (,)4.3 ( 0.)-6.6 (85)10.5 (;)-6.6 ( 95)10.6 (%)-4.3 ( C)2.6 (I)4.2 (,)-6.6 ( )11.3 (.)-6.6 (64)]TJ 0 Tc 0 Tw <96>Tj -0.002 Tc 0.002 Tw 28.152 0 Td [(1)10.5 (.)-6.6 (12,)4.3 ( )]TJ /TT2 1 Tf 0 Tc 0 Tw 2.489 0 Td (P)Tj /TT0 1 Tf 0.663 0 Td ( )Tj 0.003 Tc -0.003 Tw 0.272 0 Td (= )Tj -0.002 Tc 0.002 Tw -31.576 -1.37 Td [(.)-6.6 (24\))4.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 427.08 294.36 Tm (468)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 438.6 290.4 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(E)2 (x)8.8 (p)-11.2 (l)2.6 (or)-6 (at)-6.6 (or)-5.9 (y)8.8 ( anal)2.6 (y)-2 (s)-2 (es)-1.9 ( hav)8.8 (e s)-2 (u)10.5 (gg)-11.2 (es)8.9 (t)-6.6 (ed )11.2 (t)-6.6 (hat)4.3 ( )11.3 (c)-2 (aboz)8.9 (ant)-6.6 (i)2.6 (ni)2.7 (b m)-5.9 (ay)8.9 ( hav)8.8 (e )]TJ 0 Tc 0 Tw -3.326 -1.38 Td (a)Tj 0.554 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(g)-11.2 (r)-6 (ea)10.5 (t)-6.6 (er)5 ( c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-1.9 (al)2.6 ( bene)10.5 (f)-17.5 (i)2.6 (t)-6.6 ( )11.3 (f)4.2 (or)-6 ( )11.3 (m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (an)10.5 (c)-2 (er)-6 (s)-2 ( ha)10.5 (r)-5.9 (bor)-6 (i)2.6 (n)10.5 (g )]TJ /TT2 1 Tf -0.005 Tc 0.005 Tw [(RE)-1 (T)]TJ /TT0 1 Tf 0 Tc 0 Tw 29.522 0 Td ( )Tj -0.002 Tc 0.007 Tw -30.348 -1.37 Td [(M)15.8 (918T)-10.5 ( or)-5.9 ( )]TJ /TT2 1 Tf -0.005 Tc 0.005 Tw [(RA)-1.1 (S)]TJ /TT0 1 Tf 0 Tc 0 Tw 6.598 0 Td ( )Tj 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(C)2.6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 612.36 233.64 Tm (446)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 623.88 229.68 Tm ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(T)-13.6 (h)-3.3 (e)7.5 ( NCCN P)-1.1 (a)-3.3 (n)-3.4 (e)-3.3 (l )]TJ -0.002 Tc 0.007 Tw -20.109 -1.37 Td [(r)-6 (ec)-2 (om)5 (m)-6 (ends)8.8 ( c)-2 (aboz)8.9 (ant)-6.6 (i)2.6 (ni)2.6 (b \()-6 (c)-2 (a)10.6 (t)-6.7 (e)10.6 (g)-11.2 (or)-6 (y)8.9 ( 1\))4.9 ( bas)-2 (ed)10.6 ( on )11.2 (t)4.3 (he phas)-2 (e )11.3 (I)-6.6 (I)4.2 (I)-6.6 ( )11.3 (r)-6 (ando)10.5 (m)-5.9 (i)2.6 (z)8.9 (ed )]TJ 0 -1.38 Td [(t)-6.6 (r)-6 (i)2.6 (al)2.6 ( and FD)2.6 (A)12.8 ( appr)-6 (ov)8.8 (al)2.6 ( \()-6 (s)8.9 (ee )]TJ /TT2 1 Tf [(R)2.6 (ec)-2 (ur)-5.9 (r)4.9 (ent)4.3 ( or)4.9 ( P)2 (er)-5.9 (s)-2 (i)2.6 (s)]TJ 21 0 Td [(t)-6.6 (e)10.5 (nt)-6.6 ( D)2.6 (i)2.6 (s)-2 (eas)-2 (e)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.005 Tc 0.01 Tw 5.826 0 Td [(in)7.5 ( t)-9.6 (h)-3.4 (e)7.6 ( NCCN )]TJ -0.002 Tc 0.007 Tw -26.826 -1.37 Td [(G)-6.6 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( 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(c)-2.1 (a)10.6 (t)-6.6 (e)10.5 (g)-11.2 (or)-5.9 (y)8.8 ( 1)10.6 (\))-6 (;)4.3 ( or)4.9 ( 3\))4.9 ( )11.3 (c)-2 (aboz)8.9 (ant)-6.6 (i)2.6 (ni)2.6 (b \()-5.9 (c)-2 (at)-6.6 (e)10.5 (g)-11.2 (or)-6 (y)8.9 ( )]TJ EMC ET endstream endobj 872 0 obj 26393 endobj %% Contents for page 97 %% Original object ID: 195 0 873 0 obj << /Length 874 0 R >> stream Q q BT /Xi95 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 874 0 obj 245 endobj %% Contents for page 98 %% Original object ID: 196 0 875 0 obj << /Length 876 0 R >> stream q endstream endobj 876 0 obj 2 endobj %% Contents for page 98 %% Original object ID: 11437 0 877 0 obj << /Length 878 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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(e)-11.4 (nt)-17.6 ( or)-17 ( )]TJ -0.002 Tc 0.007 Tw 0 -1.37 Td [(P)2 (er)-5.9 (s)-2.1 (i)2.7 (s)-2 (t)-6.6 (ent)4.2 ( D)2.6 (i)2.7 (s)-2 (eas)-1.9 (e)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 8.598 0 Td [(i)2.6 (n )11.2 (t)-6.6 (he)10.5 ( N)2.6 (C)2.6 (C)2.6 (N)2.6 ( G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( M)15.8 (edul)]TJ 14.989 0 Td [(l)2.6 (ar)-6 (y)8.9 ( [)-6.6 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d])-6.6 ( )]TJ -23.587 -1.38 Td [(C)2.6 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a\))4.9 (.)-6.6 ( )11.3 (T)-10.6 (hes)8.9 (e i)2.6 (nt)-6.6 (e)10.5 (r)5 (v)8.8 (ent)-6.6 (i)2.6 (ons)-2 ( m)-5.9 (ay)8.9 ( be c)-2 (ons)-2 (i)2.6 (de)10.5 (r)-6 (ed )11.3 (f)-6.6 (or)4.9 ( as)-2 (y)8.9 (m)-6 (pt)-6.6 (o)10.5 (m)-5.9 (at)-6.6 (i)2.6 (c)8.9 ( )]TJ 0 -1.37 Td [(di)2.6 (s)-2 (t)-6.6 (ant)-6.6 ( )11.2 (m)-5.9 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (as)8.9 (es)-2 ( )11.3 (\()-6 (es)-2 (pe)10.5 (c)-2 (i)2.7 (al)2.6 (l)-8.2 (y)8.8 ( f)-17.5 (o)10.6 (r)-6 ( p)10.5 (r)-5.9 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(n or)-5.9 ( C)2.6 (E)1.9 (A)2 ( al)2.6 (one.)]TJ 0 Tc 0 Tw 20.5 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -20.5 -2.37 Td [(I)-6.6 (n )11.3 (t)-6.6 (he s)-2 (e)10.5 (t)-6.6 (t)-6.6 (i)2.6 (n)10.5 (g o)10.5 (f)-6.6 ( s)-2 (y)8.9 (m)-6 (pt)-6.6 (o)10.5 (m)-6 (at)-6.6 (i)2.6 (c)8.9 ( di)2.6 (s)-2 (eas)-2 (e o)10.5 (r)-5.9 ( p)10.6 (r)-6 (o)10.5 (g)-11.2 (r)-5.9 (es)8.9 (s)-2 (i)2.6 (on,)-6.6 ( t)-6.6 (he)10.6 ( N)2.6 (C)2.6 (C)2.6 (N)2.6 ( P)1.9 (anel)2.6 ( )]TJ 0 -1.38 Td [(r)-6 (ec)-2 (om)5 (m)-6 (ends)8.8 ( t)-6.6 (he)10.5 ( )11.3 (f)-17.5 (ol)2.7 (l)2.6 (ow)13.5 (i)2.6 (n)-11.2 (g:)-6.6 ( 1)10.6 (\))-6 ( v)8.9 (andet)-6.6 (ani)2.6 (b )11.3 (\()-5.9 (c)-2 (at)-6.6 (e)10.5 (g)-11.2 (o)10.5 (r)4.9 (y)8.9 ( 1\))-6 (;)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 288.96 339.84 Tm [(444,)-1.8 (4)-17 (66,)-19.1 (47)-17 (1)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 327.72 335.88 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(2\))-6 ( )]TJ 0.007 Tw -27.837 -1.37 Td [(c)-2 (aboz)8.9 (ant)-6.6 (i)2.6 (ni)2.6 (b \()-5.9 (c)-2 (at)-6.6 (e)10.6 (g)-11.3 (or)-6 (y)8.9 ( 1)10.5 (\))-5.9 (;)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 150.24 324.72 Tm (447)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 161.76 320.76 Tm ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(3)-3.3 (\))-9 ( c)-5 (lin)-3.4 (ic)-5 (a)-3.3 (l t)1.2 (r)-9 (ia)-3.3 (l;)-9.6 ( o)-3.4 (r)1.9 ( 4)-3.3 (\))1.9 ( )]TJ -0.002 Tc 0.007 Tw 8.913 0 Td [(c)-2 (ons)-2 (i)2.6 (der)-5.9 ( o)10.5 (t)-6.6 (her)4.9 ( s)-2 (m)-6 (al)2.6 (l)]TJ 0 Tc 0 Tw 8.924 0 Td (-)Tj -0.002 Tc 0.007 Tw -30.641 -1.38 Td [(m)-6 (ol)2.6 (ec)-2 (ul)2.6 (e )11.2 (k)-12.8 (i)2.6 (nas)-2 (e i)2.6 (nhi)2.6 (bi)2.6 (t)-6.6 (or)4.9 (s)-2 ( \()-6 (i)2.6 (e,)4.3 ( s)-2 (o)10.6 (r)-6 (a)10.5 (f)-17.4 (eni)2.6 (b,)4.3 ( s)-2 (uni)2.6 (t)-6.6 (i)2.6 (ni)2.6 (b,)4.3 ( )]TJ 0.002 Tw [(l)2.6 (env)8.9 (at)-6.6 (i)2.6 (ni)2.6 (b,)-6.7 ( )]TJ 0.007 Tw 26.978 0 Td [(paz)8.9 (opani)2.6 (b\))-5.9 ( i)2.6 (f)-6.6 ( )]TJ -26.978 -1.37 Td [(c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.7 ( t)-6.6 (r)-5.9 (i)2.6 (al)2.7 (s)-2.1 (,)-6.6 ( v)8.9 (andet)-6.6 (ani)2.6 (b,)4.2 ( or)4.9 ( c)-2 (aboz)8.9 (ant)-6.7 (i)2.7 (ni)2.6 (b ar)-5.9 (e no)10.5 (t)-6.6 ( )11.2 (av)8.9 (ai)-8.2 (l)2.6 (abl)2.6 (e or)-6 ( )]TJ 0.002 Tw 0 -1.38 Td [(appr)-6 (opr)-5.9 (i)2.6 (at)-6.6 (e)10.5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 82.32 279.12 Tm [(341,)-1.8 (4)-17 (72)]TJ 0 Tc 0 Tw 3.621 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.328 0 Td [(47)-17 (6)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 121.44 275.16 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)4.3 (f)-17.5 ( )11.2 (t)-6.6 (h)10.6 (e pat)-6.6 (i)2.6 (ent)4.3 ( pr)-5.9 (o)10.5 (gr)-6 (es)-2 (s)-2 (es)8.9 ( on )11.2 (v)8.9 (andet)-6.6 (ani)2.6 (b)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.002 Tw 17.511 0 Td [(or)-6 ( )]TJ 0.007 Tw -26.663 -1.37 Td [(c)-2 (aboz)8.8 (ant)-6.6 (i)2.7 (ni)2.6 (b,)-6.6 ( s)-2 (y)8.8 (s)-2 (t)-6.6 (em)-6 (i)2.6 (c)-2 ( c)8.9 (hem)-6 (ot)-6.6 (he)10.6 (r)-6 (apy)]TJ 0 Tc 0 Tw 16.62 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(c)-2 (an be)10.5 ( ad)10.6 (m)-6 (i)2.6 (ni)2.6 (s)-2 (t)-6.6 (er)-5.9 (ed)10.5 ( us)-2 (i)2.6 (ng )]TJ -16.902 -1.37 Td [(dac)-2 (ar)-6 (baz)8.9 (i)2.6 (ne or)-5.9 ( c)-2 (o)10.5 (m)-5.9 (bi)2.6 (nat)4.3 (i)2.6 (ons)-2 ( i)2.6 (nc)-2 (l)2.6 (udi)2.6 (ng)-11.2 ( dac)-2 (a)10.6 (r)-6 (baz)8.9 (i)2.6 (ne.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 276.72 248.88 Tm [(413,)-1.8 (4)-17 (77)]TJ 0 Tc 0 Tw 3.621 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.328 0 Td [(4)-17 (79)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 315.84 244.92 Tm ( )Tj -0.004 Tc 0.009 Tw 0.283 0 Td [(EBR)0.6 (T)-12.5 ( o)-2.4 (r)2.9 ( )]TJ -0.002 Tc 0.007 Tw -26.761 -1.38 Td [(I)-6.6 (M)15.8 (R)2.6 (T)-10.6 ( c)-2 (an be)10.5 ( us)-1.9 (ed)10.5 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( l)2.6 (o)]TJ 10.63 0 Td [(c)-2 (al)2.6 ( s)-2 (y)8.8 (m)-5.9 (pt)-6.6 (om)4.9 (s)-2 (.)4.2 ( I)-6.6 (n)10.6 (t)-6.6 (r)-6 (av)8.8 (enous)-2 ( bi)2.6 (s)-2 (phos)-2 (phonat)-6.6 (e)10.5 ( )]TJ -10.63 -1.37 Td [(t)-6.6 (her)-6 (apy)8.9 ( or)4.9 ( denos)-2 (u)10.5 (m)-5.9 (ab c)8.8 (an be c)-2 (ons)-2 (i)2.6 (de)10.5 (r)-5.9 (ed )11.3 (f)-6.7 (or)4.9 ( bon)10.5 (e m)-6 (e)10.6 (t)-6.7 (as)-2 (t)-6.6 (a)10.5 (s)-2 (es)]TJ 0 Tc 0 Tw 27.707 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 332.52 218.52 Tm (395)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 1.983 0 Td [(39)-17 (7)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 357.96 214.56 Tm ( )Tj 0.283 0 Td (B)Tj -0.002 Tc 0.002 Tw 0.663 0 Td [(es)-2 (t)-6.7 ( )]TJ 0.007 Tw -31.239 -1.38 Td [(s)-2 (uppor)-5.9 (t)-6.7 (i)2.7 (v)8.8 (e c)-2 (ar)-5.9 (e)]TJ 0 Tc 0 Tw 6.815 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(i)2.6 (s)-2 ( )-10.6 (al)2.6 (s)-2 (o r)-6 (e)10.6 (c)-2 (om)-5.9 (m)-6 (end)10.5 (ed)]TJ 0 Tc 0 Tw (.)Tj 9.739 0 Td ( )Tj 0.272 0 Td ( )Tj EMC /P <>BDC -0.002 Tc -0.004 Tw -17.109 -2.37 Td [(R)2.6 (es)-2 (ul)2.6 (t)-6.6 (s)-2 ( f)-6.6 (r)-6 (om)4.9 ( )-10.6 (c)]TJ -0.005 Tc 0.01 Tw 6.38 0 Td [(lin)-3.3 (ic)-5 (a)-3.4 (l t)-9.6 (r)-9 (ia)-3.3 (l)10.4 (s)-5 ( )]TJ -0.002 Tc 0.007 Tw [(hav)8.9 (e s)-1.9 (how)13.4 (n)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 10.728 0 Td [(t)-6.6 (he e)10.5 (f)-6.6 (f)-6.6 (ec)8.8 (t)-6.6 (i)2.6 (v)8.9 (enes)-2 (s)-2 ( o)10.5 (f)-17.5 ( nov)8.9 (el)2.6 ( )]TJ -17.109 -1.38 Td [(m)-6 (ul)2.6 (t)-6.6 (i)2.6 (t)-6.6 (ar)4.9 (g)-11.2 (e)10.5 (t)-6.6 (ed)10.5 ( t)-6.6 (he)10.5 (r)-5.9 (api)2.6 (es)-2 ( i)]TJ 0.002 Tw 10.63 0 Td [(nc)-2 (l)2.6 (udi)2.6 (ng)]TJ 0 Tc 0 Tw 3.717 0 Td ( )Tj -0.005 Tc 0.005 Tw 0.283 0 Td [(s)-5 (u)-3.4 (n)-3.3 (it)-9.6 (in)-3.4 (ib)]TJ 0 Tc 0 Tw 3.652 0 Td (,)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 228.48 161.88 Tm [(341,)-1.8 (34)-17 (2)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 253.56 157.92 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(s)-2 (or)-6 (a)10.5 (f)-17.5 (eni)2.6 (b,)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 305.16 161.88 Tm [(402,)-1.8 (47)-17 (3)]TJ 0 Tc 0.005 Tw 11.04 -0 0 11.04 330.24 157.92 Tm ( )Tj -0.002 Tc 0.002 Tw -27.783 -1.37 Td [(l)2.6 (env)8.9 (at)-6.6 (i)2.6 (ni)2.6 (b,)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 72.96 146.76 Tm [(4)-17 (76)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 84.6 142.8 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(and paz)8.8 (opa)-11.2 (ni)2.6 (b)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 159.96 146.76 Tm [(47)-17 (5)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 171.6 142.8 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (n M)15.7 (T)-10.5 (C)2.6 (.)-6.6 ( S)1.9 (ev)8.9 (er)-5.9 (e or)4.9 ( )11.2 (f)-6.6 (at)-6.6 (al)2.6 ( s)-2 (i)2.6 (de)10.5 ( e)10.6 (f)-6.7 (f)-6.6 (ec)-2 (t)4.2 (s)-2 ( )11.3 (f)-6.6 (r)-6 (o)10.6 (m)-6 ( )]TJ -13.696 -1.38 Td [(k)-12.9 (i)2.6 (nas)-1.9 (e)10.5 ( i)2.6 (nhi)2.6 (bi)2.7 (t)-6.6 (or)-6 (s)-1.9 ( i)2.6 (nc)-2 (l)2.6 (ude )11.3 (bl)2.6 (eedi)2.6 (ng)-11.2 (,)-6.6 ( hy)8.8 (per)5 (t)-6.7 (ens)-2 (i)2.7 (on,)4.2 ( )11.3 (and l)2.6 (i)2.6 (v)8.8 (er)-6 ( t)-6.6 (ox)8.8 (i)2.7 (c)-2 (i)2.6 (t)-6.6 (y)8.8 (;)-6.6 ( )]TJ 0 -1.37 Td [(how)13.5 (e)-11.2 (v)8.9 (er)-6 (,)-6.6 ( m)-5.9 (any)8.9 ( s)-2 (i)2.7 (de e)10.5 (f)-6.6 (f)-6.6 (e)10.5 (c)-2 (t)-6.6 (s)-2 ( )]TJ 12.359 0 Td [(c)-2 (an be)10.5 ( m)-6 (ana)10.6 (g)-11.3 (ed)10.5 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 245.04 116.4 Tm [(364,)-1.8 (3)-17 (67,)-19.1 (399)-16.9 (,)-1.9 (4)-17 (03)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 297.36 112.44 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(B)2 (ec)-2 (aus)-2 (e)]TJ 0 Tc 0 Tw ( )Tj -0.013 Tc 0.013 Tw 4.163 0 Td [(s)-13 (o)-11.3 (m)-17 (e )]TJ -0.002 Tc 0.007 Tw -29.25 -1.38 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( )11.3 (m)-6 (ay)8.8 ( hav)8.9 (e i)2.6 (ndol)2.6 (ent)-6.6 ( and)10.5 ( as)-2 (y)8.9 (m)-6 (pt)-6.6 (o)10.5 (m)-6 (at)-6.6 (i)2.6 (c)8.9 ( di)2.6 (s)8.9 (eas)-2 (e,)-6.6 ( po)10.5 (t)-6.6 (ent)-6.6 (i)2.6 (al)2.6 (l)2.6 (y)]TJ 0 Tc 0 Tw 28.957 0 Td ( )Tj -0.011 Tc 0.011 Tw 0.283 0 Td [(t)-15.6 (o)-9.4 (xi)-6.4 (c)-11 ( )]TJ -0.002 Tc 0.007 Tw -29.239 -1.37 Td [(t)-6.6 (her)-6 (apy)8.9 ( m)-6 (ay)8.9 ( no)10.5 (t)-6.6 ( be)10.5 ( appr)4.9 (opr)-6 (i)2.6 (at)-6.6 (e.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 179.64 86.04 Tm (364)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 191.16 82.08 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -15.467 -2.37 Td [(N)2.6 (ov)8.8 (el)2.6 ( t)-6.6 (her)-6 (api)2.7 (es)-2 ( and )11.2 (t)-6.6 (he )11.3 (m)-6 (ana)10.6 (g)-11.2 (em)-6 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (a)10.5 (gg)-11.2 (r)-6 (es)-2 (s)-2 (i)13.5 (v)8.9 (e )-10.5 (M)15.8 (T)-10.6 (C)2.6 ( hav)8.9 (e been )]TJ 0.002 Tw 0 -1.38 Td [(r)-6 (ev)8.9 (i)2.6 (e)-11.2 (w)13.5 (ed.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 70.56 44.64 Tm [(32)-17 (3,)-1.9 (4)-16.9 (13,)-19.1 (48)-17 (0)]TJ 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 5.931 0 Td [(48)-17 (3)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 123.48 40.68 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(O)4.3 (f)-6.6 ( i)2.6 (nt)-6.6 (er)-6 (es)8.8 (t)-6.6 (,)4.3 ( c)-2 (al)2.7 (c)-2 (i)2.6 (t)-6.6 (oni)2.7 (n l)2.6 (ev)8.9 (el)2.6 (s)-2 ( dec)-2 (r)-5.9 (eas)-2 (ed d)10.5 (r)-6 (a)10.6 (m)-6 (at)-6.7 (i)2.7 (c)-2 (al)2.6 (l)2.6 (y)8.9 ( )]TJ -0.004 Tw 25.217 42.87 Td [(a)10.5 (f)-17.5 (t)-6.6 (e)10.6 (r)-6 ( )-10.6 (v)8.9 (andet)-6.6 (ani)2.6 (b t)-6.6 (her)-6 (apy)]TJ 0 Tc 0 Tw 10.75 0 Td (,)Tj 0.272 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(w)13.5 (hi)2.6 (c)-2 (h di)2.7 (d not)-6.6 ( di)2.6 (r)-6 (ec)8.8 (t)-6.6 (l)2.6 (y)8.9 ( c)-2 (or)-5.9 (r)-6 (el)2.6 (a)]TJ [(t)-6.7 (e)10.6 ( w)13.4 (i)2.7 (t)-6.7 (h c)-2 (hang)-11.3 (e)10.6 (s)-2 ( i)2.6 (n )]TJ -11.304 -1.38 Td [(t)-6.6 (um)-5.9 (o)10.5 (r)-5.9 ( v)8.8 (ol)2.6 (um)]TJ 0.002 Tw 5.489 0 Td (e;)Tj 0 Tc 0 Tw 0.826 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(t)-6.6 (hus)8.9 (,)4.2 ( c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n m)-6 (ay)8.8 ( no)10.5 (t)-6.6 ( be)10.6 ( a )11.3 (r)-6 (el)2.6 (i)2.6 (abl)2.6 (e m)-6 (ar)4.9 (k)-12.9 (e)10.5 (r)-5.9 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.7 (u)10.6 (m)-6 (or)4.9 ( )]TJ 0.002 Tw -6.598 -1.37 Td [(r)-6 (es)-2 (pons)-2 (e)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 4.391 0 Td [(i)2.6 (n)10.5 ( pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( )11.3 (r)-6 (ec)8.8 (ei)2.6 (v)-2 (i)2.6 (ng)-11.3 ( )0.5 (R)2.6 (E)12.8 (T)-10.6 ( i)2.6 (nhi)2.7 (bi)2.6 (t)-6.6 (or)4.9 ( t)-6.6 (he)10.5 (r)4.9 (apy)]TJ 0 Tc 0 Tw 18.413 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 659.88 487.56 Tm [(47)-17 (1)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 671.52 483.6 Tm ( )Tj 0.283 0 Td (A)Tj 0.663 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(phas)-2 (e 2)10.5 ( t)4.3 (r)-6 (i)2.7 (al)2.6 ( )]TJ -0.005 Tc 0.005 Tw [(in)-3.3 ( )]TJ -0.002 Tc 0.007 Tw -25.37 -1.38 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h pr)-6 (o)10.6 (gr)-5.9 (es)-2 (s)-2 (i)2.6 (v)8.9 (e m)-5.9 (e)10.5 (t)-6.6 (as)-2 (t)-6.7 (a)10.6 (t)-6.6 (i)2.6 (c)-2 ( M)15.8 (T)-10.6 (C)2.6 ( as)8.9 (s)-2 (es)-2 (s)8.8 (ed )0.5 (t)4.2 (r)-5.9 (eat)4.2 (m)-5.9 (ent)4.2 ( us)-2 (i)2.6 (n)10.5 (g)-11.2 ( )]TJ 0 -1.37 Td [(pr)-6 (et)-6.6 (a)10.6 (r)4.9 (g)-11.2 (et)-6.6 (ed)10.5 ( ant)-6.6 (i)]TJ 0 Tc 0 Tw 6.989 0 Td <96>Tj -0.002 Tc 0.007 Tw 0.554 0 Td [(C)2.6 (E)2 (A)1.9 ( r)-5.9 (a)10.5 (di)2.7 (oi)2.6 (m)-5.9 (m)-6 (uno)]TJ [(t)-6.6 (he)10.5 (r)-5.9 (apy)8.9 ( w)13.5 (i)2.7 (t)-6.7 (h )]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 639.84 457.2 Tm [(1)-17 (31)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 651.48 453.24 Tm (I)Tj 0.283 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 657.72 457.2 Tm (484)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 669.24 453.24 Tm ( )Tj 0.283 0 Td (O)Tj -0.002 Tc 0.007 Tw 0.783 0 Td [(v)8.9 (er)-5.9 (al)2.6 (l)2.7 ( s)-2 (ur)-6 (v)8.9 (i)-8.2 (v)8.8 (al)2.6 ( )]TJ -25 -1.38 Td [(w)13.5 (as)-2 ( i)2.6 (m)-5.9 (pr)-5.9 (ov)8.9 (ed i)2.6 (n t)-6.6 (he s)-2 (ub)10.5 (s)-2 (et)]TJ 0 Tc 0 Tw 12.087 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(o)10.5 (f)-6.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h i)2.6 (nc)-2 (r)-5.9 (e)10.5 (as)-2 (ed c)-2 (al)2.6 (c)-2 (i)2.6 (t)]TJ 13.783 0 Td [(oni)2.6 (n doubl)2.6 (i)2.6 (ng )]TJ -0.011 Tc 0.011 Tw -26.152 -1.37 Td [(t)-15.6 (i)-6.4 (m)-15 (e)-9.3 (s.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 434.4 426.84 Tm (485)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 445.92 422.88 Tm ( )Tj 0.283 0 Td ( )Tj EMC /H1 <>BDC /TT1 1 Tf 0.009 Tc -0.009 Tw 12.96 -0 0 12.96 405 395.28 Tm [(A)18 (n)-9.6 (aplast)-0.6 (ic )]TJ 0.01 Tw 5.426 0 Td [(Th)-18.9 (y)18.8 (roid )0.7 (Carcinoma)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj 9.565 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 376.68 Tm [(A)2 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )0.5 (c)-2 (a)10.5 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (as)-2 ( )11.3 (\()-6 (A)12.9 (T)-10.6 (C)2.6 (s)-2 (\))4.9 ( ar)-6 (e)10.6 ( a)10.5 (gg)-11.2 (r)-5.9 (es)8.9 (s)-2 (i)2.6 (v)8.9 (e undi)2.6 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (at)-6.6 (e)10.5 (d )]TJ 0 -1.38 Td [(t)-6.6 (um)-5.9 (o)10.5 (r)-5.9 (s)-2 (,)4.2 ( w)13.5 (i)2.6 (t)-6.6 (h a di)2.7 (s)-2 (eas)-2 (e)]TJ 0 Tc 0 Tw (-)Tj -0.005 Tc 0.01 Tw 10.25 0 Td [(s)5.9 (p)-3.4 (e)-3.3 (c)-5 (if)-20.5 (ic)5.9 ( m)-8.9 (o)7.5 (r)-9 (t)-9.6 (a)-3.3 (lit)-9.7 (y)5.9 ( )]TJ -0.002 Tc 0.007 Tw [(appr)-6 (oa)10.6 (c)8.8 (hi)2.6 (ng)-11.3 ( 100)10.6 (%)-4.3 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 697.32 365.4 Tm (486)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 708.84 361.44 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(P)2 (at)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( )]TJ 0.007 Tw -27.804 -1.37 Td [(w)2.6 (i)2.6 (t)-6.6 (h anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( c)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (nom)4.9 (a ar)-5.9 (e)10.5 ( ol)2.6 (der)-6 ( )11.3 (t)-6.6 (han )11.3 (t)-6.6 (hos)-2 (e)10.5 ( w)13.5 (i)-8.3 (t)-6.6 (h di)13.5 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( )]TJ 0 -1.38 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (as)8.9 (,)-6.6 ( w)13.4 (i)2.7 (t)-6.7 (h a )11.2 (m)-5.9 (ean)10.5 ( a)10.5 (g)-11.2 (e a)10.6 (t)-6.6 ( di)2.6 (a)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)-2 ( o)10.6 (f)-6.7 ( )0.5 (ap)10.5 (pr)4.9 (ox)8.9 (i)2.6 (m)-5.9 (at)-6.6 (el)2.6 (y)8.8 ( )0.5 (71 y)8.8 (ear)-5.9 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 741.96 335.04 Tm (487)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 753.48 331.08 Tm ( )Tj -0.002 Tc 0.007 Tw -31.565 -1.37 Td [(Few)13.4 (er)-6 ( t)-6.6 (han 10%)6.6 ( o)10.5 (f)-6.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( a)10.6 (r)-6 (e y)8.9 (ounger)4.9 ( t)-6.6 (han)10.5 ( a)10.5 (g)-11.2 (e)10.5 ( 50 y)8.9 (ear)-5.9 (s)-2 (,)4.2 ( and)10.6 ( 60%)6.5 ( t)-6.6 (o)10.5 ( )]TJ 0 -1.38 Td [(70%)-4.3 ( o)10.5 (f)-6.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( ar)-6 (e)10.6 ( w)13.4 (o)]TJ 0.002 Tw [(m)-6 (en.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 541.44 304.68 Tm [(129,)-1.8 (4)-17 (87)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 566.52 300.72 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (he i)2.7 (nc)-2 (i)2.6 (den)]TJ -0.013 Tc 0.018 Tw [(c)-13 (e)-11.4 ( of)-17.6 ( )]TJ -0.015 Tc 0.015 Tw [(AT)-23.5 (C)-10.4 ( )]TJ -0.002 Tc 0.007 Tw 9.88 0 Td [(i)2.6 (s)8.9 ( dec)-2 (r)-6 (eas)-2 (i)2.7 (n)10.5 (g)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw -24.793 -1.37 Td [(bec)-2 (aus)-2 (e o)10.5 (f)-6.6 ( be)10.6 (t)-6.7 (t)-6.6 (e)10.6 (r)-6 ( )11.3 (m)-6 (ana)10.6 (gem)-6 (ent)4.3 ( o)10.5 (f)-6.6 ( di)13.5 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.6 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.3 (t)-6.6 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)-6 ( and)10.6 ( )]TJ 0 -1.38 Td [(bec)-2 (aus)-2 (e o)10.5 (f)-6.6 ( i)2.6 (nc)-2 (r)-5.9 (eas)8.9 (ed i)2.6 (od)10.6 (i)2.6 (ne i)2.6 (n t)-6.6 (he di)2.6 (e)10.5 (t)]TJ 0 Tc 0 Tw 17.011 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 595.92 274.32 Tm [(486,)-1.8 (48)-17 (8)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 621 270.36 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 (s)-2 ( pr)4.9 (ev)8.9 (i)2.6 (ous)-2 (l)-8.3 (y)8.9 ( m)-6 (ent)-6.6 (i)2.6 (oned,)-6.6 ( )]TJ -19.848 -1.37 Td [(anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( c)-2 (ar)4.9 (c)-2 (i)2.7 (nom)-6 (a i)2.6 (s)8.8 ( t)4.3 (he l)2.6 (eas)-2 (t)-6.6 ( )11.3 (c)-2 (om)4.9 (m)-5.9 (on )11.3 (t)-6.7 (y)8.9 (pe o)10.6 (f)-6.7 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.6 (.)]TJ 0 Tc 0 Tw 30.196 0 Td ( )Tj -0.004 Tc 0.004 Tw 0.283 0 Td [(An)-2.4 ( )]TJ -0.002 Tc 0.007 Tw -30.478 -1.38 Td [(av)8.8 (er)-6 (ag)-11.2 (e o)10.5 (f)]TJ 0 Tc 0 Tw 4.717 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(63)10.5 (,)-6.6 (229)]TJ 0 Tc 0 Tw ( )Tj -0.013 Tc 0.013 Tw 3.326 0 Td [(p)-11.3 (at)-17.6 (i)-8.4 (e)-11.4 (nt)-17.6 (s)]TJ -0.002 Tc 0.007 Tw 3.478 0 Td [(/)-6.6 (y)8.9 (ear)-6 ( w)13.5 (er)-5.9 (e )]TJ -0.004 Tw [(di)2.6 (a)10.5 (g)-11.2 (nos)-2 (ed)10.5 ( w)2.7 (i)2.6 (t)]TJ 0.007 Tw 11.011 0 Td [(h t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.6 ( )]TJ -22.815 -1.37 Td [(bet)-6.6 (w)13.5 (een 2010 t)-6.6 (o)10.5 ( 2014.)4.2 ( )11.3 (O)4.3 (f)-6.7 ( )0.5 (t)-6.7 (hes)-2 (e)10.6 ( )]TJ 0.002 Tw [(63)10.5 (,)-6.6 (229)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.002 Tw 17.793 0 Td [(pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)]TJ 0.007 Tw 3.478 0 Td [(,)-6.6 ( onl)2.6 (y)8.9 ( 514 pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( )11.3 (\()-6 (0.)-6.6 (8)10.5 (%)6.6 (\))]TJ 0 Tc 0 Tw 11.304 0 Td ( )Tj -0.002 Tc 0.002 Tw -32.576 -1.38 Td (had )Tj 0.007 Tw 1.946 0 Td [(anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( c)-2 (a)10.5 (r)-6 (c)-2 (i)2.7 (nom)5 (a)]TJ 0 Tc 0 Tw (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 532.92 213.6 Tm (29)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 540.6 209.64 Tm ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -12.283 -2.37 Td [(A)2 (ppr)-6 (ox)8.8 (i)2.6 (m)-5.9 (at)-6.6 (el)2.6 (y)8.9 ( 50%)-4.3 ( o)10.5 (f)-6.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.7 (s)-2 ( )0.5 (w)13.4 (i)2.6 (t)-6.6 (h )]TJ -0.015 Tc 0.015 Tw [(AT)-23.6 (C)-10.3 ( )]TJ -0.002 Tc 0.007 Tw 18.065 0 Td [(hav)8.9 (e ei)2.6 (t)-6.6 (h)10.5 (er)-5.9 ( a)10.5 ( pr)-6 (i)2.6 (or)4.9 ( or)5 ( c)-1.9 (oex)8.8 (i)2.6 (s)-2 (t)-6.6 (ent)-6.6 ( )]TJ 0.005 Tc -0.005 Tw -18.065 -1.37 Td [(d)6.7 (i)9.6 (ffe)]TJ -0.002 Tc 0.007 Tw 1.891 0 Td [(r)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.2 (c)-1.9 (ar)-6 (c)-2 (i)2.7 (no)10.5 (m)-5.9 (a.)4.3 ( A)1.9 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( c)-2 (a)10.5 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( d)10.5 (ev)8.9 (el)2.6 (ops)-2 ( f)-6.6 (r)-5.9 (om)4.9 ( m)-5.9 (o)10.5 (r)-6 (e )]TJ -0.004 Tw -1.891 -1.38 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed t)-6.6 (u)10.5 (m)-5.9 (or)-5.9 (s)8.9 ( )-10.6 (as)8.9 ( a )]TJ 0.007 Tw 11.522 0 Td [(r)-6 (es)-2 (ul)2.7 (t)4.2 ( o)10.5 (f)-6.6 ( one)10.6 ( or)4.9 ( m)-5.9 (o)10.5 (r)-6 (e d)10.5 (edi)2.6 (f)-6.6 (f)-6.6 (er)-6 (en)10.6 (t)-6.6 (i)2.6 (at)-6.6 (i)2.6 (n)10.6 (g)-11.3 ( s)8.9 (t)-6.6 (eps)8.9 (,)-6.6 ( )]TJ -11.522 -1.37 Td [(par)-6 (t)-6.6 (i)2.7 (c)-2.1 (ul)2.6 (ar)-6 (l)2.6 (y)8.9 ( l)2.6 (os)-2 (s)-2 ( o)10.6 (f)-6.6 ( t)-6.5 (he)10.5 ( p5)10.5 (3 t)-6.6 (u)10.6 (m)-6 (or)4.9 ( s)-2 (uppr)-5.9 (e)10.5 (s)-2 (s)-2 (or)4.9 ( pr)-5.9 (o)10.5 (t)4.3 (ei)2.6 (n.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 661.2 141.96 Tm (489)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 672.72 138 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(N)2.6 (o pr)-5.9 (ec)-2 (i)2.6 (pi)2.6 (t)-6.6 (at)-6.6 (i)2.6 (ng )]TJ -24.533 -1.38 Td [(ev)8.8 (ent)-6.6 (s)-2 ( hav)8.9 (e been i)2.6 (dent)-6.6 (i)13.5 (f)-17.5 (i)13.5 (ed,)-6.6 ( and)10.5 ( t)-6.6 (he)10.5 ( m)-6 (e)10.6 (c)-2.1 (hani)2.6 (s)-2 (m)-5.9 (s)8.8 ( l)2.6 (eadi)2.6 (ng)-11.3 ( )11.3 (t)-6.6 (o a)10.5 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( )]TJ 0 -1.37 Td [(t)-6.6 (r)-6 (ans)8.9 (f)-6.6 (or)4.9 (m)-6 (at)-6.6 (i)2.6 (on)10.5 ( o)10.6 (f)-6.6 ( di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.5 (s)-2 ( a)10.6 (r)-6 (e un)10.5 (c)-2 (er)-6 (t)-6.6 (ai)2.6 (n.)4.3 ( I)-6.6 (odi)2.6 (ne)10.5 ( )]TJ 0 -1.38 Td [(de)10.5 (f)-17.5 (i)2.6 (c)-2 (i)2.6 (enc)-2 (y)8.9 ( i)2.6 (s)-2 ( as)-1.9 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (ed )11.2 (w)2.6 (i)2.7 (t)-6.7 (h A)2 (T)-10.6 (C)13.5 (.)-6.6 ( M)15.7 (or)-6 (e t)-6.6 (han)10.5 ( 80)10.5 (%)-4.3 ( o)10.5 (f)-6.6 ( pa)10.6 (t)-6.7 (i)2.7 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ -0.005 Tc 0.005 Tw [(A)-1.1 (T)-13.6 (C )]TJ -0.002 Tc 0.007 Tw 0 -1.37 Td [(hav)8.9 (e a hi)2.6 (s)-2 (t)-6.6 (or)-6 (y)8.9 ( o)10.5 (f)-6.6 ( )11.3 (g)-11.2 (oi)2.6 (t)-6.6 (e)10.5 (r)-5.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 519.48 81.24 Tm [(488,)-1.8 (4)-17 (90,)-19.1 (49)-16.9 (1)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 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/Length 880 0 R >> stream Q q BT /Xi96 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 880 0 obj 245 endobj %% Contents for page 99 %% Original object ID: 198 0 881 0 obj << /Length 882 0 R >> stream q endstream endobj 882 0 obj 2 endobj %% Contents for page 99 %% Original object ID: 11438 0 883 0 obj << /Length 884 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 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252.24 230.04 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(The appear)-6 (anc)-2 (e)10.6 ( o)10.6 (f)-6.6 ( A)12.8 (T)-10.6 (C)2.6 (s)-2 ( )]TJ -21 -1.37 Td [(v)8.9 (ar)-5.9 (i)2.6 (es)-2 ( w)2.6 (i)2.7 (del)-8.3 (y)8.9 (;)-6.6 ( m)-6 (any)8.9 ( A)12.8 (T)-10.6 (C)2.6 (s)-2 ( hav)8.8 (e m)-6 (i)2.6 (x)8.9 (ed m)-6 (o)10.6 (r)-6 (phol)2.6 (og)-11.2 (i)13.5 (es)-1.9 (.)-6.7 ( )11.3 (T)-10.6 (he)10.5 ( m)-5.9 (o)10.5 (s)-2 (t)4.2 ( c)-2 (om)4.9 (m)-5.9 (on)10.5 ( )]TJ 0 -1.38 Td [(m)-6 (or)-6 (phol)2.6 (o)10.5 (g)-11.2 (y)8.9 ( i)2.6 (s)-2 ( bi)2.7 (phas)-2 (i)2.6 (c)-2 ( s)8.9 (pi)2.6 (ndl)2.6 (e and g)-11.2 (i)2.6 (an)10.6 (t)-6.7 ( c)-2 (el)2.6 (l)2.6 ( )11.3 (t)-6.6 (um)4.9 (or)-6 (.)4.3 ( M)15.8 (ol)2.6 (ec)-2 (ul)2.7 (ar)-5.9 ( t)-6.7 (ec)-2 (hni)2.6 (q)-11.2 (ues)8.9 ( )]TJ 0 -1.37 Td [(ar)-6 (e )0.5 (no)10.5 (t)-6.6 ( )11.3 (r)-6 (ec)-2 (om)5 (m)-6 (ended)10.5 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( di)2.6 (a)10.6 (g)-11.3 (nos)-2 (i)2.6 (s)-2 ( o)10.5 (f)-6.6 ( A)12.8 (T)-10.6 (C)2.6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 237.12 188.52 Tm (488)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 248.64 184.56 Tm ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(S)-1 (o)7.5 (m)-9 (e)-3.4 (t)-9.5 (im)-9 (e)7.5 (s)-5 ( it)1.2 ( is)-5 ( d)-3.4 (i)10.5 (f)-9.6 (f)-9.6 (ic)-5 (u)-3.4 (lt)-9.6 ( )11.3 (t)-9.6 (o)-3.4 ( )]TJ -0.002 Tc 0.007 Tw -20.674 -1.38 Td [(di)2.6 (s)-2 (c)-2 (r)-6 (i)2.6 (m)-5.9 (i)2.6 (nat)-6.6 (e be)10.5 (t)-6.6 (w)13.5 (een A)2 (TC)2.6 ( )]TJ [(and ot)-6.6 (he)10.5 (r)-6 ( p)10.5 (r)-5.9 (i)2.6 (m)-6 (a)10.6 (r)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)4.9 (oi)2.6 (d m)-5.9 (al)2.6 (i)2.6 (g)-11.2 (nanc)-2 (i)2.6 (es)8.9 ( \()-6 (i)2.7 (e,)4.3 ( )]TJ 0 -1.37 Td [(M)15.8 (T)-10.6 (C)2.6 (,)-6.6 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d l)2.6 (y)8.9 (m)-6 (phom)-6 (a\))4.9 ( or)5 ( poor)-5.9 (l)2.6 (y)8.8 ( di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-6 (ent)-6.6 (i)2.7 (at)-6.6 (ed)10.5 ( c)8.8 (anc)-2 (er)-6 ( )11.3 (m)-5.9 (et)-6.6 (a)10.5 (s)-2 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (t)-6.6 (o 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o)10.5 (f)-17.5 ( v)8.9 (oc)-2 (al)2.6 ( c)8.8 (or)-5.9 (d )11.3 (m)-6 (obi)2.6 (l)2.6 (i)2.6 (t)-6.6 (y)8.9 (,)-6.6 ( and i)2.6 (m)-6 (a)10.5 (g)-11.2 (i)2.6 (n)10.6 (g s)-2 (t)-6.6 (udi)2.6 (es)8.8 (.)-6.6 ( N)2.6 (ec)8.9 (k)-2 ( )]TJ 0 -1.38 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2.1 (ound )11.2 (c)-2 (an )11.3 (r)-6 (api)2.6 (dl)2.6 (y)8.9 ( as)-2 (s)-2 (es)-2 (s)-2 ( )11.3 (t)-6.6 (um)-5.9 (o)10.5 (r)-6 ( ex)8.9 (t)-6.7 (ens)-1.9 (i)2.6 (on an)10.5 (d i)2.6 (nv)8.9 (as)-2 (i)2.6 (on.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 317.64 71.16 Tm [(49)-17 (2)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 329.28 67.2 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(C)2.6 (T)-10.6 ( s)8.9 (c)-2 (ans)-2 ( )]TJ -27.978 -1.37 Td [(o)10.5 (f)-17.4 ( )11.2 (t)-6.6 (he head)10.5 (,)-6.6 ( nec)8.9 (k)-2 (,)4.2 ( c)-2 (hes)8.9 (t)-6.6 (,)4.3 ( abdom)-6 (en)10.5 (,)-6.6 ( and)10.5 ( pel)2.6 (v)8.9 (i)2.6 (s)-2 ( c)-2 (an ac)-2 (c)-2 (ur)-6 (a)10.6 (t)-6.6 (el)2.6 (y)8.9 ( det)-6.6 (er)4.9 (m)-5.9 (i)2.6 (ne )]TJ 34.554 41.837 Td [(t)-6.6 (he ex)8.9 (t)-6.6 (ent)4.3 ( o)10.5 (f)-6.6 ( t)4.2 (he )11.2 (t)-6.6 (hy)]TJ 8.75 0 Td [(r)-6 (oi)2.6 (d t)4.2 (um)-6 (or)4.9 ( and i)2.7 (dent)-6.6 (i)13.5 (f)-17.5 (y)8.9 ( )11.2 (t)-6.6 (um)4.9 (or)4.9 ( i)2.6 (nv)8.9 (as)-2 (i)2.6 (on of)-6.6 ( t)-6.6 (he)10.5 ( )11.2 (g)-11.2 (r)-5.9 (ea)10.6 (t)-6.7 ( )]TJ -8.75 -1.38 Td [(v)8.9 (es)-2 (s)-2 (el)2.6 (s)-2 ( and upper)-6 ( )11.3 (aer)-6 (od)10.5 (i)2.6 (g)-11.2 (es)-2 (t)-6.6 (i)2.6 (v)8.9 (e t)4.2 (r)-5.9 (ac)-2 (t)4.3 ( s)8.9 (t)-6.7 (r)-5.9 (uc)8.9 (t)-6.6 (ur)-6 (es)8.8 (.)]TJ -0.022 Tc 0.022 Tw 6.96 -0 0 6.96 641.76 502.68 Tm [(49)-17.7 (4)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 653.16 498.72 Tm ( )Tj -0.004 Tc -0.002 Tw 0.283 0 Td [(PET)-12.5 (/)-8.7 (C)11.5 (T)-12.5 ( )-10.6 (s)6.8 (c)-4 (a)-2.3 (n)-2.3 (s)-4.1 ( f)-8.6 (r)-8 (o)8.6 (m)-8 ( )]TJ -0.005 Tc 0.01 Tw -22.761 -1.37 Td [(s)-5 (k)-15.9 (u)-3.3 (ll b)-3.4 (a)-3.3 (s)-5.1 (e)7.6 ( t)-9.7 (o)7.6 ( )11.2 (m)-9 (id)]TJ 0 Tc 0 Tw 7.424 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(t)-6.6 (hi)13.5 (g)-11.2 (h a)10.5 (r)4.9 (e r)-5.9 (ec)-2 (o)10.6 (m)-6 (m)-5.9 (e)10.5 (nded )11.3 (t)-6.6 (o ac)8.8 (c)-2 (ur)4.9 (at)-6.6 (el)2.6 (y)8.9 ( s)-2 (t)-6.6 (a)10.5 (g)-11.2 (e )11.3 (t)-6.6 (he pa)10.6 (t)-6.7 (i)2.7 (ent)4.2 (.)-6.6 ( )]TJ -7.761 -1.38 Td [(B)2 (one m)-5.9 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (as)8.8 (es)-2 ( a)10.5 (r)-5.9 (e us)8.8 (u)]TJ [(al)2.6 (l)-8.2 (y)8.9 ( l)2.6 (y)8.8 (t)-6.6 (i)2.6 (c)-2 (.)-6.6 ( A)2 (l)2.6 (l)2.6 ( A)2 (T)-10.6 (C)2.6 (s)-2 ( a)10.5 (r)-5.9 (e c)8.9 (ons)-2 (i)2.6 (der)-5.9 (ed s)8.8 (t)-6.6 (a)10.5 (g)-11.2 (e )11.3 (I)-6.7 (V)2 ( )11.3 (\()-6 (A)2 (,)-6.6 ( B)12.8 (,)4.2 ( )]TJ 0 -1.37 Td [(or)-6 ( C)2.6 (\))4.9 ( \()-5.9 (s)-2 (ee)10.5 ( )]TJ 0.002 Tw 4.707 0 Td [(T)-10.6 (abl)2.6 (e)]TJ 0 Tc 0 Tw ( )Tj 2.783 0 Td (1)Tj 0.543 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(i)2.6 (n )-10.6 (t)-6.6 (h)10.5 (e N)2.6 (C)2.6 (C)2.6 (N)2.6 ( )-10.6 (G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( f)-17.5 (or)4.9 ( T)-10.5 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For personal use only. Not approved for distribution. 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m)-6 (os)-1.9 (t)4.2 ( )]TJ 0.007 Tw -22.989 -1.38 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h A)12.9 (T)-10.6 (C)2.6 ( hav)8.9 (e u)10.6 (nr)-6 (es)-2 (ec)-2 (t)-6.6 (abl)2.6 (e)10.5 ( or)5 ( m)-6 (e)10.5 (t)-6.6 (as)-2 (t)4.2 (at)-6.6 (i)13.5 (c)-2 ( di)2.6 (s)-2 (eas)-2 (e.)4.2 ( )11.3 (T)-10.6 (he pa)10.5 (t)-6.6 (enc)-2 (y)8.9 ( )]TJ 0 -1.37 Td [(o)10.5 (f)-17.4 ( )11.2 (t)-6.6 (he ai)2.6 (r)-6 (w)13.5 (ay)8.9 ( s)-2 (houl)2.6 (d be a)10.6 (s)-2 (s)-2 (es)-2 (s)-2 (ed )11.3 (t)-6.6 (hr)-5.9 (ou)10.6 (g)-11.3 (hou)10.6 (t)-6.6 ( )11.2 (t)-6.6 (he )11.3 (pat)-6.6 (i)2.6 (ent)-6.6 <92>2.6 (s)-2 ( c)-2 (ou)10.5 (r)-6 (s)-2 (e.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 343.56 412.32 Tm (498)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 355.08 408.36 Tm ( )Tj 0.005 Tc -0.011 Tw 0.283 0 Td [(I)11.3 (f th)6.7 (e)]TJ 0 Tc 0 Tw 2.217 0 Td ( )Tj -0.002 Tc 0.007 Tw -32.533 -1.38 Td [(pat)-6.6 (i)2.6 (ent)-6.6 ( appea)10.5 (r)-5.9 (s)8.8 ( t)-6.5 (o)10.5 ( hav)8.8 (e r)4.9 (es)-2 (ec)-2 (t)-6.6 (abl)2.6 (e di)2.6 (s)-2 (eas)-2 (e)10.6 (,)-6.6 ( an)10.5 ( at)4.2 (t)4.3 (em)-6 (pt)4.3 ( at)4.2 ( t)-6.6 (o)10.5 (t)-6.6 (al)2.6 ( )]TJ -0.004 Tw 0 -1.37 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( )-10.6 (w)13.5 (i)2.6 (t)-6.6 (h )-10.6 (c)-2 (om)-6 (p)10.5 (l)2.6 (et)-6.6 (e g)-11.2 (r)-6 (os)8.9 (s)-2 ( t)-6.6 (um)-6 (o)10.5 (r)-5.9 ( r)-5.9 (e)]TJ 0.007 Tw [(s)-2 (ec)8.9 (t)-6.6 (i)2.6 (on s)-2 (houl)2.7 (d be )11.3 (m)-6 (ade)10.5 (,)-6.6 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ 0 -1.38 Td [(s)-2 (el)2.6 (ec)-2 (t)-6.6 (i)2.6 (v)8.9 (e r)-5.9 (es)-2 (ec)-2 (t)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( )11.3 (al)2.6 (l)2.6 ( i)2.7 (nv)8.9 (ol)-8.2 (v)8.8 (ed l)2.7 (oc)-2 (al)2.6 ( or)-5.9 ( r)-6 (e)10.5 (g)-11.2 (i)2.6 (onal)2.6 ( )11.3 (s)-2 (t)-6.7 (r)-5.9 (uc)8.9 (t)-6.6 (ur)-6 (e)10.5 (s)-2 ( and)10.6 ( nodes)-2 (.)4.2 ( )]TJ 0 -1.37 Td [(T)-10.6 (o)10.6 (t)-6.7 (al)2.6 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (o)10.5 (m)-5.9 (y)8.9 ( w)13.4 (i)2.7 (t)-6.7 (h at)-6.6 (t)-6.6 (e)10.6 (m)-6 (pt)-6.7 (ed)10.5 ( c)-2 (o)10.6 (m)-6 (pl)2.6 (et)-6.6 (e )11.2 (t)-6.6 (u)10.5 (m)4.9 (or)-6 ( r)5 (es)-2 (ec)-2 (t)-6.6 (i)2.6 (on)10.5 ( has)-2 ( no)10.5 (t)-6.6 ( )]TJ 0 -1.38 Td [(been s)-2 (how)13.5 (n t)-6.6 (o p)10.5 (r)-6 (ol)2.6 (ong s)8.8 (ur)-6 (v)8.9 (i)-8.3 (v)8.9 (al)]TJ 0 Tc 0 Tw 13.728 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(ex)8.8 (c)-2 (ept)-6.6 ( )11.3 (f)-17.5 (or)4.9 ( t)-6.6 (he)10.5 ( )11.3 (f)-17.5 (ew)13.5 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( w)13.5 (hos)-2 (e t)-6.6 (u)10.5 (m)-6 (or)-6 (s)8.9 ( )]TJ -14.011 -1.37 Td [(ar)-6 (e )0.5 (s)8.8 (m)-5.9 (al)2.6 (l)2.6 ( a)]TJ [(nd c)-2 (on)10.6 (f)-6.6 (i)2.6 (ned e)10.5 (nt)-6.6 (i)2.6 (r)-6 (el)2.6 (y)8.9 ( t)-6.6 (o )11.3 (t)-6.6 (he )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d or)4.9 ( r)-6 (e)10.5 (adi)2.6 (l)-8.3 (y)8.9 ( ex)8.9 (c)-2 (i)2.6 (s)-2 (ed )]TJ 0.002 Tw 0 -1.38 Td [(s)-2 (t)-6.6 (r)-6 (uc)8.9 (t)-6.7 (ur)-5.9 (e)10.5 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 75 306 Tm [(497,)-1.8 (49)-17 (9,)-1.9 (5)-17 (03)-17 (,)-1.8 (50)-17 (4)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 127.32 302.04 Tm ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(P)2 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( )-10.6 (need)10.5 ( t)-6.6 (o r)-6 (ec)-2 (ei)2.6 (v)8.9 (e )-10.7 (l)2.7 (ev)-2 (ot)-6.6 (hy)8.9 (r)-6 (ox)8.9 (i)2.6 (ne )-10.6 (i)2.6 (f)-17.5 ( t)-6.7 (ot)-6.6 (al)13.5 ( )]TJ 0.007 Tw -9.685 -1.37 Td [(t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( i)2.6 (s)-2 ( done)10.5 (.)]TJ 0 Tc 0 Tw 9.967 0 Td ( )Tj EMC /H3 <>BDC /TT2 1 Tf 0.01 Tc -0.01 Tw 9.96 -0 0 9.96 23.52 261.6 Tm [(R)-3 (ad)]TJ 0.016 Tc -0.005 Tw 1.928 0 Td [(i)4.9 (a)5.7 (ti)4.9 (on)0.6 ( T)0.5 (h)0.5 (e)5.7 (r)7.5 (a)5.7 (p)0.5 (y)]TJ 0 Tc 0 Tw 7 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 246.24 Tm [(E)2 (B)1.9 (R)2.6 (T)-10.5 ( o)10.5 (r)-6 ( )11.3 (I)-6.6 (M)15.8 (R)2.6 (T)-10.6 ( c)-2 (an i)2.6 (nc)8.9 (r)-6 (e)10.5 (as)-2 (e s)-2 (hor)4.9 (t)]TJ 0 Tc 0 Tw 14.957 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(t)-6.6 (er)5 (m)4.9 ( s)-2 (ur)-5.9 (v)8.8 (i)2.7 (v)8.8 (al)2.6 ( i)-8.3 (n s)-2 (om)-5.9 (e)10.5 ( pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 (s)-2 (;)4.2 ( E)2 (B)1.9 (R)2.6 (T )]TJ -0.013 Tc 0.013 Tw [(or)-17 ( )]TJ -0.002 Tc 0.007 Tw -15.283 -1.38 Td [(I)-6.6 (M)15.8 (R)2.6 (T)-10.6 ( c)-2 (an al)2.6 (s)-2 (o)]TJ 0 Tc 0 Tw 6.424 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (m)-5.9 (pr)-6 (ov)8.9 (e l)13.5 (oc)-1.9 (al)2.6 ( c)-2 (ont)4.3 (r)-6 (ol)2.6 ( and c)-2 (a)10.6 (n be)10.5 ( )11.3 (us)-2 (ed )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( pal)2.6 (l)2.6 (i)2.6 (at)-6.6 (i)2.6 (on \()-6 (e)10.5 (g,)4.3 ( t)-6.7 (o)10.6 ( )]TJ -6.707 -1.37 Td [(pr)-6 (ev)8.9 (ent)-6.6 ( as)-2 (phy)8.9 (x)8.8 (i)2.6 (at)-6.6 (i)2.6 (on)]TJ 0.004 Tc -0.004 Tw (\).)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 131.16 219.84 Tm [(455,)-19.1 (486)-17 (,)-1.8 (48)-16.9 (8,)-19.1 (501)-17 (,)-1.8 (5)-17 (05)]TJ 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 9.828 0 Td [(50)-17 (9)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 211.2 215.88 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(S)2 (ur)-5.9 (g)-11.3 (i)2.7 (c)-2 (al)2.6 ( e)10.5 (x)8.9 (c)-2 (i)2.6 (s)-2 (i)2.6 (on or)-6 ( ex)8.9 (t)-6.7 (er)-6 (nal)2.6 ( )]TJ 0.002 Tw -17.283 -1.38 Td [(i)2.6 (r)-6 (r)-5.9 (adi)2.6 (at)-6.6 (i)2.6 (on)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 4.663 0 Td [(s)-2 (houl)2.7 (d be)10.5 ( c)-2 (on)10.6 (s)-2 (i)2.6 (der)-6 (ed )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( i)2.6 (s)-2 (ol)2.6 (at)-6.6 (ed)10.5 ( s)8.8 (k)-12.8 (el)2.6 (e)10.6 (t)-6.6 (al)2.6 ( m)-5.9 (e)10.5 (t)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)-2 (.)4.3 ( Fo)10.5 (r)-6 ( )]TJ -4.663 -1.37 Td [(s)-2 (ol)2.6 (i)2.6 (t)-6.6 (ar)-5.9 (y)8.8 ( br)-6 (ai)2.6 (n l)2.7 (es)-2 (i)2.6 (ons)-2 (,)4.3 ( ei)2.6 (t)4.3 (her)]TJ 0 Tc 0 Tw 12.076 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(neu)10.5 (r)-5.9 (os)-2 (ur)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.7 ( )11.2 (r)-5.9 (es)-2 (ec)8.8 (t)-6.6 (i)2.7 (on or)4.9 ( r)-5.9 (adi)2.6 (at)-6.6 (i)2.6 (on )11.3 (t)-6.6 (her)4.9 (apy)8.9 ( i)2.6 (s)-2 ( )]TJ 0.002 Tw -12.359 -1.38 Td [(r)-6 (ec)-2 (om)5 (m)-6 (ended)10.5 (.)]TJ 0 Tc 0 Tw 6.652 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(O)-6.6 (nc)-2 (e )11.3 (br)-5.9 (a)10.5 (i)2.6 (n m)-5.9 (et)-6.6 (a)10.5 (s)-1.9 (t)-6.6 (as)-2 (es)8.8 ( ar)-6 (e)10.5 ( di)2.6 (a)10.5 (g)-11.2 (n)10.5 (os)-2 (ed,)-6.6 ( di)2.6 (s)-2 (eas)-2 (e)]TJ 0 Tc 0 Tw 20.826 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(s)-2 (pec)-2 (i)13.5 (f)-17.5 (i)2.6 (c)8.9 ( )]TJ 0.007 Tw -28.087 -1.37 Td [(m)-6 (or)4.9 (t)-6.6 (al)2.6 (i)2.6 (t)-6.6 (y)8.8 ( i)2.7 (s)-2 ( v)8.9 (er)-6 (y)8.9 ( hi)2.6 (g)-11.2 (h,)4.2 ( w)13.5 (i)2.6 (t)-6.6 (h a )11.3 (r)-6 (epor)4.9 (t)-6.6 (ed )11.3 (m)-6 (edi)2.6 (an s)-2 (u)10.6 (r)-6 (v)8.9 (i)2.6 (v)8.9 (a)-11.3 (l)2.7 ( o)10.5 (f)-17.5 ( 1)10.5 (.)-6.6 (3 )11.2 (m)-5.9 (ont)-6.6 (h)10.5 (s)-2 (.)]TJ 0 Tc 0 Tw 30.011 0 Td ( )Tj -0.002 Tc -0.004 Tw -30.011 -1.38 Td [(E)2 (nt)-6.6 (er)-5.9 (al)2.6 ( )-10.6 (nu)10.5 (t)-6.6 (r)-5.9 (i)2.6 (t)-6.6 (i)2.6 (on m)-6 (ay)8.8 ( )-10.6 (be us)-2 (e)10.6 (f)-17.5 (ul)2.6 ( f)-17.5 (o)10.6 (r)-6 ( s)-2 (om)-5.9 (e)10.5 ( )-10.6 (pat)-6.6 (i)2.6 (en)10.6 (t)-6.6 (s)-2 ( w)13.5 (ho )-10.6 (hav)8.9 (e )-10.6 (di)2.6 (f)-6.6 (f)-17.5 (i)2.6 (c)-2 (ul)2.6 (t)-6.6 (y)8.8 ( )]TJ 0.007 Tw 0 -1.37 Td [(s)-2 (w)13.5 (al)-8.2 (l)2.6 (o)-11.2 (w)13.4 (i)2.7 (ng)-11.2 ( \()-6 (s)-2 (ee )]TJ /TT3 1 Tf [(P)12.9 (r)-6 (i)2.6 (nc)-2 (i)2.6 (pl)2.6 (es)-2 ( of)4.2 ( N)2.6 (ut)4.2 (r)-5.9 (i)2.6 (t)-6.6 (i)2.6 (on:)-6.6 ( M)4.9 (anage)10.5 (m)-5.9 (ent)4.2 ( and S)2 (uppo)10.5 (r)-5.9 (t)-6.6 (i)2.6 (v)-2 (e)10.5 ( C)2.6 (ar)4.9 (e)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 0 -1.38 Td [(i)2.6 (n t)-6.6 (he N)2.6 (C)2.6 (C)2.6 (N)2.6 ( )11.2 (G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( f)-6.6 (or)4.9 ( H)2.6 (ead and N)2.6 (ec)8.9 (k)-2 ( C)2.6 (anc)8.8 (er)-6 (,)4.3 ( av)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.005 Tc 0.005 Tw 0 -1.37 Td [(www)10.5 (.)-9.6 (NC)-11.3 (CN.)-9.6 (o)-3.4 (r)-8.9 (g)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 101.16 94.44 Tm (\).)Tj 0 Tc 0 Tw 0.609 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)4.3 (f)-6.7 ( en)10.5 (t)-6.6 (er)4.9 (al)2.6 ( )11.3 (f)-17.5 (eedi)2.6 (ng i)2.6 (s)-2 ( c)-2 (on)10.5 (s)-2 (i)2.6 (der)-6 (ed,)4.2 ( )11.3 (a c)-2 (ar)-6 (e)10.6 (f)-6.7 (ul)2.6 ( c)-2 (onv)8.9 (er)-5.9 (s)-2 (at)-6.6 (i)2.6 (on)10.5 ( )]TJ ET /CS0 cs 0 0.357 0.6 scn 23.52 92.4 77.64 0.84 re f BT /CS1 cs 0 scn 11.04 -0 0 11.04 23.52 79.2 Tm [(s)-2 (houl)2.6 (d oc)-2 (c)-2 (ur)5 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (he pa)10.5 (t)4.3 (i)2.6 (ent)-6.6 ( about)4.3 ( t)-6.6 (hei)13.5 (r)-6 ( w)13.5 (i)2.6 (s)-2 (hes)-2 (.)-6.6 ( )]TJ 0 Tc 0 Tw 21.489 0 Td ( )Tj ET EMC BT /H3 <>BDC /TT2 1 Tf 0.01 Tc 0.001 Tw 9.96 -0 0 9.96 405 514.8 Tm [(S)2.3 (yst)-6.4 (em)-4.6 (i)-1.2 (c T)-5.5 (h)-5.5 (er)1.4 (ap)-5.5 (y)]TJ 0 Tc 0 Tw 8.759 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 405 499.44 Tm [(T)-10.6 (r)-5.9 (e)10.5 (at)4.3 (m)-5.9 (ent)]TJ 0 Tc 0 Tw 4.543 0 Td ( )Tj -0.005 Tc 0.01 Tw 0.283 0 Td [(w)10.5 (it)-9.6 (h)-3.4 ( s)-5 (in)-3.4 (g)-14.2 (le)]TJ 0 Tc 0 Tw 4.652 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(d)10.5 (r)4.9 (ug c)-1.9 (hem)-5.9 (o)10.5 (t)-6.6 (her)-5.9 (apy)8.8 ( i)2.7 (s)-2 ( )11.2 (not)4.3 ( )11.2 (v)8.9 (er)-6 (y)8.9 ( ef)-6.6 (f)-17.5 (e)10.6 (c)-2 (t)-6.6 (i)2.6 (v)8.8 (e,)-6.6 ( al)2.6 (t)-6.6 (hou)10.5 (g)-11.2 (h)10.5 ( )]TJ -9.815 -1.38 Td [(s)-2 (om)-6 (e pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( m)-6 (ay)8.9 ( s)-2 (how)13.5 ( di)2.6 (s)-2 (eas)-2 (e )11.2 (r)-5.9 (es)-2 (pons)-2 (e )11.3 (or)4.9 ( ha)10.6 (v)8.8 (e s)-2 (t)-6.6 (abl)2.6 (e di)2.6 (s)]TJ 0.002 Tw 27.141 0 Td [(eas)-2 (e.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 731.64 488.16 Tm [(488,)-1.8 (50)-17 (9)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 756.72 484.2 Tm ( )Tj -0.002 Tc 0.007 Tw -31.859 -1.37 Td [(H)2.6 (y)8.9 (per)-6 (f)-17.4 (r)-6 (a)10.5 (c)-2 (t)-6.6 (i)2.6 (onat)-6.6 (ed)10.6 ( E)1.9 (B)2 (R)2.6 (T,)4.3 ( c)-1.9 (om)-6 (bi)2.6 (ned)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h r)-6 (adi)2.6 (os)-2 (ens)-2 (i)2.6 (t)-6.6 (i)2.6 (z)8.9 (i)2.6 (ng)-11.2 ( dos)-2 (es)-2 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.38 Td [(dox)8.9 (or)-5.9 (ubi)2.6 (c)-2 (i)2.6 (n,)-6.6 ( m)-6 (ay)]TJ 0 Tc 0 Tw 7.533 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (nc)-2 (r)-6 (eas)8.9 (e t)-6.6 (he)10.5 ( l)2.6 (oc)-2 (al)2.6 ( r)-5.9 (es)-2 (pons)8.8 (e )11.3 (r)-6 (at)-6.6 (e)10.5 ( t)-6.6 (o)10.5 ( about)4.3 ( 80%)6.5 (,)-6.6 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ -7.815 -1.37 Td [(s)-2 (ubs)-2 (eq)-11.2 (uen)10.5 (t)-6.6 ( )11.2 (m)-5.9 (edi)2.6 (an )11.3 (s)-2 (ur)-5.9 (v)8.8 (i)2.7 (v)8.8 (al)2.6 ( of)-17.5 ( )0.5 (1)10.5 ( y)8.8 (ear)-5.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 590.4 442.68 Tm (510)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 601.92 438.72 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(D)2.6 (i)2.6 (s)-2 (t)-6.6 (ant)4.3 ( )11.2 (m)-5.9 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.8 ( t)-6.6 (hen)10.6 ( bec)-2 (o)10.6 (m)4.9 (e )]TJ -18.12 -1.38 Td [(t)-6.6 (he l)2.6 (eadi)2.6 (ng c)-2 (aus)-2 (e)10.5 ( o)10.5 (f)-6.6 ( dea)10.5 (t)-6.6 (h.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 537.24 427.44 Tm (511)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 548.76 423.48 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(S)2 (i)2.6 (m)-6 (i)2.6 (l)2.6 (ar)-6 ( i)2.6 (m)-5.9 (pr)-5.9 (ov)8.9 (em)-5.9 (e)10.5 (nt)-6.6 ( i)2.6 (n l)2.6 (oc)-2 (al)2.6 ( )0.5 (di)2.6 (s)-2 (eas)-2 (e)10.5 ( c)-2 (o)]TJ -0.013 Tc 0.013 Tw [(nt)-17.6 (r)-16.9 (ol)-8.4 ( )]TJ -0.002 Tc 0.007 Tw -13.304 -1.37 Td [(has)-2 ( been )11.3 (r)-6 (epor)4.9 (t)-6.6 (ed w)13.5 (i)2.6 (t)-6.6 (h a)10.6 ( c)-2 (om)-6 (bi)2.6 (na)10.5 (t)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( )]TJ 0.002 Tw [(hy)8.8 (per)5 (f)-6.7 (r)-5.9 (a)10.5 (c)-2 (t)-6.6 (i)2.6 (onat)-6.6 (ed)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 25.989 0 Td [(R)13.5 (T and )]TJ 0.002 Tw -25.989 -1.38 Td [(dox)8.9 (or)-5.9 (ubi)2.6 (c)-2 (i)2.6 (n)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 5.424 0 Td [(bas)-2 (ed r)-5.9 (e)10.5 (g)-11.2 (i)2.6 (m)4.9 (ens)-2 (,)-6.6 ( )11.2 (f)-6.5 (ol)2.6 (l)2.6 (ow)13.5 (ed by)8.9 ( debul)2.6 (k)-12.9 (i)2.6 (ng s)-2 (ur)4.9 (g)-11.2 (e)10.5 (r)-5.9 (y)8.8 ( i)2.6 (n r)-6 (es)-2 (pons)-1.9 (i)2.5 (v)8.9 (e )]TJ -5.424 -1.37 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( o)10.5 (r)-5.9 ( o)10.5 (t)-6.6 (he)10.6 (r)-6 ( )11.3 (m)-6 (ul)2.6 (t)-6.6 (i)2.6 (m)-6 (o)10.6 (dal)2.7 (i)2.6 (t)-6.6 (y)8.8 ( appr)-6 (oac)-2 (hes)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 615.48 381.96 Tm [(509,)-1.8 (51)-17 (2)]TJ 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 3.948 0 Td [(5)-17 (14)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 654.6 378 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(I)-6.6 (M)15.8 (R)2.6 (T)-10.6 ( m)-5.9 (ay)8.9 ( be us)-2 (e)10.6 (f)-6.6 (ul)2.6 ( t)-6.6 (o)10.5 ( )]TJ -0.004 Tw -22.891 -1.38 Td [(r)-6 (educ)-2 (e t)-6.6 (ox)8.8 (i)2.7 (c)-2 (i)2.6 (t)-6.6 (y)8.8 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 478.32 366.72 Tm [(45)-17 (5,)-1.9 (4)-16.9 (88,)-19.1 (51)-17 (5)]TJ 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 5.931 0 Td [(51)-17 (9)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 531.24 362.76 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(H)2.6 (ow)13.4 (e)-11.2 (v)8.9 (er)-6 (,)-6.6 ( t)-6.6 (he)10.6 ( addi)2.6 (t)-6.6 (i)2.6 (on o)10.6 (f)-6.7 ( l)2.6 (ar)4.9 (g)-11.2 (e)10.5 (r)-5.9 ( dos)-2 (e)10.5 (s)-2 ( o)10.5 (f)-6.6 ( o)10.5 (t)-6.6 (her)4.9 ( )]TJ -11.717 -1.37 Td [(c)-2 (hem)-5.9 (ot)-6.6 (he)10.5 (r)-6 (apeut)-6.6 (i)2.6 (c)8.9 ( dr)-5.9 (u)10.5 (g)-11.2 (s)8.9 ( )11.2 (has)-2 ( not)4.2 ( been a)10.5 (s)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (ed)10.5 ( )11.3 (w)2.6 (i)2.6 (t)-6.6 (h i)2.6 (m)-6 (pr)-6 (ov)8.8 (ed c)-2 (on)10.5 (t)-6.6 (r)-6 (ol)2.6 ( o)10.5 (f)-6.6 ( )]TJ -0.005 Tc 0.005 Tw 0 -1.38 Td [(d)-3.3 (is)-5 (t)-9.7 (a)]TJ -0.002 Tc 0.007 Tw 2.109 0 Td [(nt)-6.7 ( di)2.6 (s)-2 (eas)-2 (e)10.5 ( or)4.9 ( w)13.5 (i)2.6 (t)-6.6 (h i)2.6 (m)-5.9 (pr)-5.9 (ov)8.9 (ed s)-2 (u)10.5 (r)-5.9 (v)8.8 (i)-8.2 (v)8.9 (al)2.6 (.)-6.6 ( )]TJ 0 Tc 0 Tw ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -2.109 -2.37 Td [(S)2 (y)8.8 (s)-2 (t)-6.6 (em)-6 (i)2.6 (c)-2 ( t)-6.6 (he)10.5 (r)-6 (apy)8.9 ( r)-5.9 (ec)-2 (o)10.5 (m)5 (m)-6 (endat)-6.6 (i)2.6 (ons)8.9 ( ar)-5.9 (e)10.5 ( des)-2 (c)-2 (r)-5.9 (i)2.6 (be)10.5 (d i)2.6 (n )0.5 (t)-6.7 (he)10.5 ( al)2.6 (g)-11.2 (o)10.5 (r)-6 (i)2.6 (t)-6.6 (h)10.6 (m)-6 ( )11.3 (\()]TJ -0.013 Tc 0.013 Tw 29.859 0 Td [(s)-13 (e)-11.3 (e )]TJ /TT3 1 Tf -0.002 Tc 0.007 Tw -29.859 -1.37 Td [(S)2 (y)-2 (s)-2 (t)-6.7 (em)-5.9 (i)2.6 (c)8.8 ( Ther)-5.9 (apy)8.9 ( f)-6.7 (o)10.6 (r)-6 ( A)2 (n)10.5 (apl)2.6 (as)-2 (t)-6.7 (i)2.7 (c)-2 ( Thy)-2 (r)-5.9 (oi)2.6 (d)10.5 ( )0.5 (C)2.6 (ar)-5.9 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (a)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.002 Tc -0.004 Tw 23.272 0 Td [(i)2.6 (n t)-6.6 (he)]TJ 0 Tc 0 Tw ( )Tj -0.005 Tc 0.005 Tw 2.717 0 Td (NCCN)Tj 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw -25.989 -1.38 Td [(G)-6.6 (ui)2.7 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (or)5 ( A)2 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)8.9 ( [)4.2 (T)-10.5 (hy)8.9 (r)-5.9 (oi)2.6 (d])-6.6 ( C)2.6 (a)10.5 (r)-6 (c)-2 (i)2.7 (nom)-6 (a)]TJ 0 Tc 0 Tw 20.272 0 Td (\))Tj 0.337 0 Td (.)Tj -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 635.64 279.84 Tm [(488,)-1.8 (520)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 660.6 275.88 Tm ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(R)2.6 (ec)-2 (om)-5.9 (m)-6 (ended )]TJ 0.007 Tw -23.435 -1.37 Td [(r)-6 (e)10.6 (g)-11.3 (i)2.7 (m)-6 (ens)-2 ( i)2.6 (nc)-2 (l)2.6 (ude)10.5 ( pac)-2 (l)2.6 (i)2.6 (t)-6.6 (a)10.6 (x)8.8 (el)2.6 ( and c)-2 (ar)-6 (bopl)2.6 (at)-6.6 (i)2.6 (n c)-2 (o)10.5 (m)-5.9 (b)10.5 (i)2.6 (nat)-6.6 (i)2.6 (ons)-2 (,)-6.6 ( doc)-2 (e)10.6 (t)-6.7 (ax)8.9 (el)2.6 ( and )]TJ 0 -1.38 Td [(dox)8.9 (or)-5.9 (ubi)2.6 (c)-2 (i)2.6 (n )0.5 (c)-2 (om)-5.9 (bi)2.6 (nat)-6.6 (i)2.6 (ons)-2 (,)-6.6 ( pac)-2 (l)2.6 (i)2.7 (t)-6.7 (ax)8.9 (el)2.6 ( al)2.6 (one,)-6.6 ( o)10.6 (r)-6 ( do)10.6 (x)8.8 (or)-6 (ubi)2.7 (c)-2 (i)2.6 (n al)2.6 (one.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 719.4 249.48 Tm [(488)-16.9 (,)-1.9 (5)-16.9 (21)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 744.6 245.52 Tm ( )Tj -0.002 Tc 0.007 Tw -30.761 -1.37 Td [(D)2.6 (abr)-6 (a)10.6 (f)-17.5 (eni)2.6 (b pl)2.6 (us)-2 ( )11.3 (t)-6.6 (r)-6 (a)10.5 (m)-5.9 (e)10.5 (t)-6.6 (i)2.6 (ni)2.6 (b c)-2 (om)-6 (bi)2.7 (na)10.5 (t)-6.6 (i)2.6 (on or)4.9 ( l)2.6 (ar)-6 (ot)4.2 (r)-5.9 (ec)8.9 (t)-6.6 (i)2.6 (ni)2.6 (b ar)-6 (e al)2.6 (s)-2 (o)10.5 ( opt)-6.6 (i)2.6 (ons)8.9 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )]TJ /TT3 1 Tf -0.004 Tc 0.004 Tw 0 -1.38 Td [(BR)0.6 (AF)]TJ /TT0 1 Tf 0 Tc 0 Tw 2.652 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(V)2 (600E)2 ( m)-6 (u)10.5 (t)-6.6 (at)-6.6 (i)2.6 (on)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 7.435 0 Td [(p)10.5 (os)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (e or)-6 ( )]TJ /TT3 1 Tf -0.005 Tc 0.005 Tw [(NT)-2.7 (RK)]TJ /TT0 1 Tf 0 Tc 0 Tw 7.522 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.272 0 Td [(g)-11.2 (ene f)-6.6 (us)8.9 (i)2.6 (on)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 5.489 0 Td [(pos)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (e t)-6.6 (um)-6 (o)10.6 (r)-6 (s)-2 (,)4.3 ( )]TJ 0.002 Tw -23.652 -1.37 Td [(r)-6 (es)-2 (pec)-2 (t)-6.6 (i)2.6 (v)8.9 (el)2.6 (y)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 466.08 204 Tm [(35)-17 (5,)-1.9 (5)-16.9 (22)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 491.28 200.04 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(T)-10.6 (he N)13.5 (C)2.6 (C)2.6 (N)2.7 ( P)1.9 (anel)2.6 ( r)-6 (ec)-2 (om)4.9 (m)-5.9 (ends)8.9 ( m)-6 (ol)2.6 (ec)-2 (ul)2.6 (ar)4.9 ( t)-6.6 (es)8.9 (t)-6.6 (i)2.6 (n)10.5 (g)-11.2 ( )11.3 (t)-6.6 (o hel)2.6 (p)10.6 ( )]TJ -8.098 -1.38 Td [(i)2.6 (nf)-17.5 (o)10.5 (r)-5.9 (m)4.9 ( dec)-2 (i)2.6 (s)-2 (i)2.6 (ons)-2 ( )11.3 (r)-6 (e)10.5 (g)-11.2 (ar)-6 (di)13.4 (ng s)-2 (y)8.9 (s)-2 (t)-6.6 (em)-6 (i)2.6 (c)8.9 ( t)-6.6 (he)10.6 (r)-6 (apy)8.9 ( an)]TJ -0.004 Tw [(d t)-6.6 (o )-10.6 (de)10.5 (t)-6.6 (er)5 (m)-6 (i)2.6 (ne )-10.6 (el)2.6 (i)2.6 (g)-11.2 (i)2.6 (bi)2.7 (l)2.6 (i)2.6 (t)-6.6 (y)8.8 ( f)-17.5 (or)4.9 ( )]TJ 0.007 Tw 0 -1.37 Td [(c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.7 ( t)-6.6 (r)-5.9 (i)2.6 (al)2.7 (s)-2.1 (.)-6.6 ( )11.3 (T)-10.5 (he )11.3 (dos)-2 (a)10.5 (ge and )11.3 (f)-6.6 (r)-6 (e)10.5 (q)-11.2 (uenc)-2 (y)8.9 ( o)10.5 (f)-6.6 ( ad)10.5 (m)-5.9 (i)2.6 (ni)2.7 (s)-2 (t)-6.7 (r)-5.9 (at)-6.6 (i)2.6 (on)10.5 ( o)10.5 (f)-6.6 ( al)2.6 (l)2.6 ( t)-6.6 (he)10.6 ( )]TJ 0 -1.38 Td [(r)-6 (ec)-2 (om)5 (m)-6 (ended)10.5 ( s)-2 (y)8.9 (s)-2 (t)-6.6 (em)-6 (i)2.6 (c)8.9 ( t)4.2 (her)-5.9 (apy)8.9 ( ag)-11.2 (en)10.5 (t)-6.6 (s)8.8 ( ar)-6 (e)10.6 ( pr)-5.9 (ov)8.9 (i)2.6 (ded )0.5 (i)2.6 (n t)-6.6 (he)10.6 ( al)2.6 (gor)-5.9 (i)2.6 (t)-6.6 (h)10.5 (m)-5.9 (.)4.2 ( )]TJ 0 -1.37 Td [(E)2 (i)2.6 (t)-6.6 (her)-6 ( c)-2 (onc)-2 (u)10.5 (r)-5.9 (r)-6 (en)10.5 (t)-6.6 ( )11.3 (c)-2 (hem)-6 (o)10.5 (r)-5.9 (adi)2.6 (at)-6.6 (i)2.6 (on or)4.9 ( c)-2 (he)10.5 (m)-6 (ot)-6.6 (he)10.6 (r)-6 (ap)10.5 (y)8.9 ( al)2.6 (one r)-6 (eg)-11.3 (i)13.5 (m)-5.9 (ens)-2 ( )11.3 (m)-6 (ay)8.9 ( )]TJ 0 -1.38 Td [(be us)-2.1 (ed dependi)2.6 (n)10.5 (g o)]TJ [(n )11.2 (t)-6.6 (h)10.5 (e c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( s)-2 (et)-6.6 (t)-6.6 (i)2.6 (n)10.5 (g)-11.2 (;)4.3 ( how)13.4 (ev)8.9 (e)-11.3 (r)-5.9 (,)4.3 ( c)-2.1 (hem)-6 (o)10.5 (r)-5.9 (adi)2.6 (at)-6.6 (i)2.6 (on )0.5 (i)2.5 (s)8.9 ( )]TJ 0 -1.37 Td [(g)-11.2 (ene)10.5 (r)-5.9 (al)2.6 (l)2.6 (y)8.9 ( m)-6 (or)-6 (e )]TJ 6.87 0 Td [(t)-6.6 (ox)8.8 (i)2.6 (c)-2 (.)-6.6 ( I)4.3 (f)-6.6 ( u)10.5 (s)-2 (i)2.6 (ng)-11.2 ( )11.3 (c)-2 (hem)-6 (o)10.6 (r)-6 (adi)2.6 (at)-6.6 (i)2.6 (on,)4.3 ( t)-6.7 (he)10.5 ( A)2 (T)-10.6 (A)12.8 ( )0.5 (G)-6.7 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )]TJ -6.87 -1.38 Td [(r)-6 (ec)-2 (om)5 (m)-6 (end)10.5 ( us)-2 (i)2.6 (ng w)13.5 (eek)-12.9 (l)13.5 (y)8.9 ( c)-2 (hem)-6 (ot)-6.6 (he)10.5 (r)-5.9 (apy)8.9 ( r)-6 (e)10.5 (g)-11.2 (i)2.6 (m)-5.9 (en)10.5 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 653.28 97.68 Tm (488)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 664.8 93.72 Tm ( )Tj 0.283 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -23.815 -2.37 Td [(S)2 (y)8.8 (s)-2 (t)-6.6 (em)-6 (i)2.6 (c)-2 ( t)-6.6 (he)10.5 (r)-6 (apy)8.9 ( al)2.6 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For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 894 0 obj 245 endobj %% Contents for page 101 %% Original object ID: 202 0 895 0 obj << /Length 896 0 R >> stream q endstream endobj 896 0 obj 2 endobj %% Contents for page 101 %% Original object ID: 11445 0 897 0 obj << /Length 898 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 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(i)13.4 (g)-11.2 (ue)10.5 ( )]TJ 0 -1.38 Td [(\()-6 (38%)-4.3 (\))5 (,)4.2 ( py)8.8 (r)-5.9 (ex)8.9 (i)2.6 (a \()-6 (37%)-4.3 (\))4.9 ( an)]TJ -0.004 Tw 10.739 0 Td [(d )-10.7 (naus)-2 (ea \()-6 (35%)6.6 (\))-6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 222.96 309.48 Tm (522)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 234.48 305.52 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(B)2 (as)-2 (e)10.5 (d on )11.3 (t)-6.6 (hes)-2 (e da)10.5 (t)-6.6 (a,)4.3 ( )11.3 (t)-6.7 (he FD)2.6 (A)12.8 ( )]TJ -19.391 -1.37 Td [(appr)-6 (ov)8.8 (ed dabr)-6 (a)10.5 (f)-17.4 (eni)2.6 (b)10.5 (/)-6.6 (t)4.3 (r)-6 (a)10.5 (m)-5.9 (et)-6.6 (i)2.6 (ni)2.6 (b )11.2 (f)-6.6 (or)4.9 ( A)1.9 (T)-10.5 (C)13.4 ( )0.5 (w)13.4 (i)2.6 (t)-6.6 (h )]TJ /TT2 1 Tf -0.004 Tc 0.004 Tw [(BR)0.6 (AF)]TJ /TT0 1 Tf 0 Tc 0 Tw 22.478 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(V)2 (600E)2 ( m)-6 (u)10.5 (t)-6.6 (at)-6.6 (i)2.6 (on)10.6 ( on )]TJ -22.761 -1.38 Td [(M)15.8 (a)-11.2 (y)8.8 ( 4,)-6.6 ( 2018.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 87.24 279.12 Tm (526)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 98.76 275.16 Tm ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -6.815 -2.37 Td [(A)2 ( pool)2.6 (ed anal)2.6 (y)8.9 (s)-2 (i)2.6 (s)-2 ( o)10.5 (f)-17.5 ( 3)10.5 ( s)-2 (t)4.3 (udi)2.6 (es)-2 ( \()-6 (a pha)10.5 (s)-2 (e 1)10.6 ( i)2.6 (nc)-2 (l)2.6 (udi)2.6 (ng adul)2.6 (t)-6.6 (s)-2 (,)4.3 ( a)10.5 ( phas)-2 (e 1)10.5 (/)-6.6 (2 )]TJ -0.005 Tc 0.01 Tw 0 -1.37 Td [(in)-3.3 (v)5.8 (o)-14.2 (lv)-5 (in)-3.4 (g)-14.2 ( c)-5 (h)-3.4 (ild)-3.3 (r)]TJ -0.002 Tc 0.007 Tw 6.543 0 Td [(en,)4.3 ( and a)10.5 ( )11.3 (phas)-2 (e 2 i)2.6 (nv)8.9 (ol)2.7 (v)8.8 (i)2.6 (ng)-11.2 ( adol)2.6 (es)-2 (c)-2 (ent)-6.6 (s)-2 ( and)10.5 ( adul)2.6 (t)-6.6 (s)8.9 (\))-6 ( )]TJ -6.543 -1.38 Td [(s)-2 (t)-6.6 (udi)2.6 (ed t)-6.6 (he)10.6 ( s)-2 (a)10.5 (f)-6.6 (et)-6.6 (y)8.9 ( and)10.5 ( e)10.5 (f)-6.6 (f)-17.4 (i)2.6 (c)-2 (a)10.5 (c)-2 (y)8.9 ( o)10.5 (f)-17.5 ( l)2.6 (ar)-6 (o)10.5 (t)-6.6 (r)-5.9 (e)10.5 (c)-2 (t)-6.6 (i)2.6 (ni)2.6 (b i)2.6 (n p)10.5 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.4 (i)2.6 (t)-6.6 (h )]TJ /TT2 1 Tf -0.005 Tc 0.005 Tw [(NT)-2.7 (RK)]TJ /TT0 1 Tf 0 Tc 0 Tw 29.804 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.272 0 Td [(g)-11.2 (ene)10.5 ( )]TJ -30.076 -1.37 Td [(f)-6.6 (us)-2 (i)2.7 (on)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 3 0 Td [(pos)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (e t)-6.6 (u)10.5 (m)-5.9 (or)-5.9 (s)8.9 (,)-6.6 ( i)2.6 (n)10.5 (c)-2 (l)2.6 (udi)2.6 (ng)-11.3 ( )0.5 (7)10.5 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)-6 ( o)10.5 (f)-6.6 ( w)13.5 (hi)2.6 (c)-2 (h 1 )]TJ -3 -1.38 Td [(pat)-6.6 (i)2.6 (ent)-6.6 ( had)10.5 ( A)12.8 (T)-10.5 (C)2.6 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 106.2 192.24 Tm [(355,)-1.8 (52)-17 (7)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 131.28 188.28 Tm ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(For)-6 ( t)-6.6 (he )-10.6 (w)13.4 (hol)2.7 (e )-10.6 (popul)2.6 (at)-6.6 (i)2.6 (on,)-6.6 ( t)-6.6 (he O)-6.6 (R)2.6 (R)2.6 ( )-10.6 (w)13.5 (as)-2 ( 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(ponded )11.3 (t)-6.6 (o l)2.6 (ar)-6 (o)10.6 (t)-6.7 (r)5 (ec)-2 (t)-6.6 (i)2.6 (ni)2.6 (b,)-6.6 ( w)13.5 (i)2.6 (t)-6.6 (h 1 c)-2 (o)10.5 (m)-5.9 (pl)2.6 (et)-6.6 (e)10.5 ( r)-6 (es)-2 (po)]TJ 21.5 0 Td [(ns)-2 (e and 4)10.5 ( par)4.9 (t)-6.6 (i)2.6 (al)2.6 ( )]TJ 0.002 Tw -21.5 -1.38 Td [(r)-6 (es)-2 (pons)-2 (es)8.9 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 77.4 131.52 Tm (527)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 88.92 127.56 Tm ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(Lar)-6 (ot)-6.6 (r)-5.9 (ec)8.9 (t)-6.6 (i)2.6 (n)10.5 (i)2.6 (b )0.5 (w)13.4 (as)-2 ( f)-17.5 (ound)10.5 ( t)-6.6 (o)10.5 ( be w)13.5 (el)2.6 (l)]TJ 0 Tc 0 Tw 14.783 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(t)4.3 (ol)2.6 (er)-6 (at)-6.6 (ed as)8.9 ( t)-6.6 (h)10.5 (e )11.2 (m)-5.9 (aj)-8.2 (o)10.5 (r)-6 (i)2.6 (t)-6.6 (y)8.9 ( )]TJ -21.326 -1.37 Td [(\()-6 (93%)-4.2 (\))4.9 ( o)10.5 (f)-6.6 ( adv)8.8 (er)-6 (s)-2 (e ev)8.8 (ent)-6.6 (s)8.9 ( )11.3 (w)13.4 (er)-6 (e g)-11.2 (r)-6 (ade)10.5 (s)-2 ( 1)10.6 ( or)4.9 ( 2 and)10.5 ( n)10.5 (o t)4.2 (r)-5.9 (eat)4.2 (m)-5.9 (ent)]TJ 0 Tc 0 Tw 27.196 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(r)-6 (el)2.6 (at)-6.7 (ed)10.5 ( )]TJ 0.007 Tw -27.533 -1.38 Td [(adv)8.9 (er)-5.9 (s)-2 (e ev)8.8 (ent)-6.6 (s)-2 ( o)10.6 (f)-6.6 ( )11.2 (g)-11.2 (r)-6 (ade)10.5 (s)-2 ( 3 o)10.6 (r)-6 ( 4)10.5 ( oc)-2 (c)-2 (u)10.5 (r)-6 (r)-5.9 (ed)10.6 ( i)2.6 (n m)-5.9 (o)10.5 (r)-6 (e)10.5 ( t)-6.6 (han)10.6 ( 5%)6.6 ( o)10.5 (f)-6.6 ( pat)-6.6 (i)2.6 (ent)4.3 (s)-2 (.)]TJ -0.004 Tc 0.004 Tw 6.96 -0 0 6.96 364.32 101.16 Tm (355)Tj 0 Tc 0 Tw 11.04 -0 0 11.04 375.84 97.2 Tm ( )Tj -0.002 Tc 0.007 Tw -31.913 -1.37 Td [(B)2 (as)-2 (ed on )11.3 (t)-6.6 (hes)-2 (e da)10.5 (t)-6.6 (a)10.5 (,)-6.6 ( )11.3 (t)-6.6 (he)10.6 ( FD)2.6 (A)1.9 ( appr)-6 (ov)8.8 (ed l)2.6 (ar)-5.9 (o)10.5 (t)-6.6 (r)-6 (ec)8.8 (t)-6.6 (i)2.6 (ni)2.6 (b )11.2 (f)-17.5 (or)]TJ 0 Tc 0 Tw 24.652 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(m)-6 (e)10.6 (t)-6.6 (as)8.9 (t)-6.6 (at)-6.6 (i)2.6 (c)8.9 ( s)-2 (ol)2.6 (i)2.6 (d 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0 Tc 0 Tw 29.141 0 Td <97>Tj -0.002 Tc 0.007 Tw -29.141 -1.38 Td [(r)-6 (e)10.6 (g)-11.3 (ar)-5.9 (dl)2.6 (es)-2 (s)8.8 ( o)10.6 (f)-6.6 ( s)-2 (ur)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( )11.2 (r)-5.9 (e)10.5 (s)-2 (ec)-2 (t)-6.7 (i)2.7 (on)]TJ 0 Tc 0 Tw <97>Tj -0.002 Tc 0.007 Tw [(s)-2 (houl)2.6 (d be)10.6 ( c)-2 (ons)-2 (i)13.4 (der)]TJ -0.005 Tc 0.01 Tw 23.152 0 Td [(e)-3.3 (d)-3.4 ( )11.2 (f)-9.6 (o)-3.3 (r)1.9 ( c)-5 (lin)-3.4 (ic)-5 (a)-3.3 (l t)-9.7 (r)-8.9 (ia)-3.4 (ls)-5 (.)1.3 ( )]TJ -0.002 Tc 0.007 Tw -23.152 -1.37 Td [(P)2 (r)-6 (ev)8.8 (i)2.6 (ous)-2 ( c)-2 (l)2.7 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( t)-6.6 (r)-6 (i)2.6 (al)2.6 (s)-2 ( )11.3 (f)-17.5 (or)5 ( A)2 (T)-10.6 (C)13.5 ( hav)8.9 (e t)-6.6 (es)8.9 (t)-6.7 (ed )11.2 (t)-6.6 (her)-5.9 (api)13.4 (es)-2 ( i)2.6 (nc)-2 (l)2.6 (udi)2.6 (ng)-11.2 ( )]TJ 0 -1.38 Td [(f)-6.6 (os)-2 (br)-6 (e)10.6 (t)-6.6 (abul)2.6 (i)2.6 (n \()-6 (and)10.6 ( i)2.6 (t)-6.6 (s)8.8 ( par)5 (ent)-6.6 ( d)10.6 (r)-6 (u)10.5 (g)-11.2 (,)4.3 ( c)-2 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For personal use only. Not approved for distribution. 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(r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (39)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /H1 <>BDC /TT1 1 Tf 0.009 Tc -0.009 Tw 12.96 -0 0 12.96 23.52 501.72 Tm [(Ref)-0.6 (erences)]TJ 0 Tc 0 Tw 5.491 0 Td ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 482.88 Tm [(1.)-6.7 ( M)15.8 (az)-2 (z)8.8 (af)-17.5 (er)4.9 (r)-6 (i)2.7 ( E)2 (L.)4.2 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ [(c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-6 (a:)4.2 ( P)2 (api)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( and )11.2 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 (.)-6.6 ( )11.3 (I)-6.7 (n:)4.3 ( M)15.7 (az)-2 (z)8.9 (af)-17.5 (er)4.9 (r)-5.9 (i)2.6 ( )]TJ 0 -1.141 Td [(E)2 (L,)-6.6 ( S)2 (am)-5.9 (aan)10.5 ( N)2.6 (,)4.2 ( eds)8.8 (.)-6.6 ( E)2 (nd)10.6 (oc)-2 (r)-6 (i)2.6 (ne )11.2 (T)-10.5 (um)4.9 (or)-6 (s)8.9 (.)-6.6 ( C)2.6 (a)10.5 (m)-5.9 (br)-5.9 (i)2.6 (d)10.5 (g)-11.2 (e)10.5 (:)-6.6 ( B)2 (l)2.6 (ac)8.9 (k)-12.9 (w)13.5 (el)2.7 (l)2.6 ( S)1.9 (c)-2 (i)2.6 (ent)-6.6 (i)2.6 (f)-17.4 (i)2.6 (c)-2 ( )]TJ 0 -1.152 Td [(P)2 (ubl)2.6 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (ons)-2 ( 1993:)-6.6 (278)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 10.152 0 Td [(3)10.5 (33.)]TJ 0 Tc 0 Tw 1.924 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -12.076 -2.141 Td [(2.)-6.7 ( H)2.7 (e)10.5 (g)-11.2 (edus)8.9 ( L.)4.3 ( C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.7 ( pr)-6 (ac)-2 (t)-6.6 (i)2.6 (c)-2 (e.)4.2 ( )11.3 (T)-10.6 (he )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d nodul)2.6 (e.)-6.6 ( N)2.6 ( E)2 (n)10.5 (g)-11.2 (l)2.6 ( )11.3 (J)-2 ( M)15.8 (ed )]TJ 0.002 Tw 0 -1.141 Td [(2004;)-6.6 (351:)-6.6 (1764)]TJ 0 Tc 0 Tw 6.652 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1771.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.989 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (15496625)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 408.6 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 406.56 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 384.96 Tm [(3.)-6.7 ( C)2.7 (ooper)4.9 ( D)2.6 (S)1.9 (,)4.3 ( D)2.6 (oher)-6 (t)-6.6 (y)8.9 ( )11.2 (G)-6.6 (M)15.8 (,)-6.6 ( H)2.6 (aug)-11.2 (en)10.5 ( B)1.9 (R)2.6 (,)4.3 ( et)4.2 ( al)2.6 (.)-6.6 ( R)13.4 (ev)8.9 (i)2.6 (s)-2 (ed A)2 (m)-6 (er)-5.9 (i)2.6 (c)-2 (an )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.141 Td [(A)2 (s)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (i)2.6 (on m)-6 (ana)10.5 (g)-11.2 (e)10.6 (m)-6 (en)10.5 (t)-6.6 ( )11.2 (g)-11.2 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( pa)10.6 (t)-6.7 (i)2.7 (ent)-6.6 (s)8.9 ( )11.3 (w)2.6 (i)2.6 (t)-6.6 (h )0.5 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d nodul)2.6 (es)-2 ( and)10.5 ( )]TJ -0.004 Tw 0 -1.141 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed t)-6.6 (hy)]TJ 0.007 Tw 7.37 0 Td [(r)-6 (oi)2.6 (d c)-2 (an)10.5 (c)-2 (er)-6 (.)4.3 ( )11.3 (T)-10.6 (hy)8.9 (r)-5.9 (oi)2.6 (d 2009;)-6.6 (19)10.6 (:)-6.7 (116)10.5 (7)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 15.511 0 Td [(1214.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.88 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19860577)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 347.04 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 345 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 323.4 Tm [(4.)-6.7 ( E)2 (z)8.9 (z)8.8 (at)-6.6 ( S)1.9 (,)-6.6 ( S)2 (a)10.5 (r)-5.9 (t)-6.6 (i)2.6 ( D)2.6 (A)1.9 (,)4.3 ( C)2.6 (ai)2.5 (n D)2.6 (R)2.6 (,)-6.6 ( B)12.8 (r)-5.9 (auns)-2 (t)-6.6 (ei)2.6 (n )11.3 (G)-6.6 (D)2.6 (.)4.3 ( )11.2 (T)-10.5 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d i)2.6 (nc)-2 (i)2.6 (dent)-6.6 (al)2.6 (om)-6 (as)-2 (.)-6.6 ( )]TJ 0 -1.141 Td [(P)2 (r)-6 (ev)8.8 (al)2.6 (enc)-2 (e )0.5 (by)8.9 ( pal)2.6 (pat)-6.6 (i)2.6 (on and)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 12.859 0 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2 (ono)10.5 (gr)-5.9 (aphy)8.9 (.)-6.6 ( A)12.8 (r)4.9 (c)-2 (h I)-6.6 (n)10.5 (t)-6.6 (er)-6 (n)10.5 ( M)15.8 (ed )]TJ 0.002 Tw -12.859 -1.152 Td [(1994;)-6.6 (154:)-6.6 (1838)]TJ 0 Tc 0 Tw 6.652 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1840.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.989 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8053752)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 285.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 283.44 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 261.84 Tm [(5.)-6.7 ( R)2.7 (on E)12.8 (,)-6.6 ( Lubi)2.6 (n)10.6 ( J)-2 (H)2.6 (,)4.2 ( S)2 (hor)4.9 (e R)2.7 (E)1.9 (,)-6.6 ( e)10.5 (t)-6.6 ( al)13.5 (.)-6.6 ( )11.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)8.9 (er)-6 ( a)10.5 (f)-6.6 (t)-6.6 (e)10.5 (r)-5.9 ( ex)8.9 (pos)-2 (ur)-6 (e)10.5 ( t)-6.6 (o)10.5 ( )]TJ 0 -1.152 Td [(ex)8.8 (t)-6.6 (er)-6 (nal)2.6 ( r)-5.9 (adi)2.6 (at)]TJ 6.326 0 Td [(i)2.6 (on:)4.3 ( a pool)13.5 (ed anal)2.6 (y)8.9 (s)-2 (i)2.6 (s)-2 ( of)-6.6 ( s)-2 (ev)8.9 (en s)8.9 (t)-6.6 (u)10.5 (di)2.6 (es)-2 (.)-6.6 ( R)2.6 (adi)2.6 (at)-6.7 ( R)2.6 (es)8.9 ( )]TJ 0.002 Tw -6.326 -1.141 Td [(1995;)-6.6 (141:)-6.6 (259)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(277.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (7871153)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 223.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 221.88 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 200.16 Tm [(6.)-6.7 ( S)2 (c)-2 (hnei)2.6 (der)4.9 ( A)1.9 (B)2 (,)4.3 ( B)1.9 (e)10.5 (k)-12.8 (er)4.9 (m)-5.9 (an C)13.5 (,)-6.6 ( Lel)2.6 (and J)8.9 (,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( )11.3 (Thy)8.9 (r)-5.9 (oi)2.6 (d nodul)2.6 (es)-2 ( )0.5 (i)2.6 (n t)-6.6 (he)10.6 ( )]TJ -0.005 Tc 0.005 Tw 0 -1.141 Td [(f)-9.6 (o)-3.4 (llo)-3.3 (w)]TJ 0 Tc 0 Tw 2.533 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up of)-6.7 ( i)2.7 (r)-6 (r)-5.9 (adi)2.6 (a)10.5 (t)-6.6 (ed i)2.6 (n)10.5 (di)2.6 (v)-2 (i)2.6 (dual)2.6 (s)-2 (:)-6.6 ( c)-2 (om)-6 (pa)10.5 (r)-5.9 (i)2.6 (s)-2 (on o)10.5 (f)-6.6 ( )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d ul)2.6 (t)-6.6 (r)-6 (as)-2 (ound)10.6 ( w)13.4 (i)2.7 (t)-6.7 (h )]TJ -2.87 -1.141 Td [(s)-2 (c)-2 (anni)2.6 (ng and pal)2.7 (pat)-6.7 (i)2.7 (on)10.5 (.)-6.6 ( )11.3 (J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.6 (nol)2.7 ( M)15.7 (et)-6.6 (ab 1997;)-6.6 (82:)-6.6 (4020)]TJ 0 Tc 0 Tw 27.707 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(4027.)4.3 ( )]TJ 0.007 Tw -28.043 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (939870)]TJ 0 Tc 0 Tw (6)Tj EMC ET /Span <>BDC BT /CS1 cs 0 scn 11.04 -0 0 11.04 309.12 162.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 160.2 222.48 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 138.6 Tm [(7.)-6.7 ( N)2.7 (oone A)1.9 (M)15.8 (,)-6.6 ( H)2.6 (ow)13.4 (l)2.6 (ader)-6 ( N)2.6 (,)-6.6 ( )0.5 (K)1.9 (r)-5.9 (apc)-2.1 (ho)10.5 ( M)15.8 (,)-6.6 ( et)4.3 ( al)2.6 (.)-6.6 ( S)1.9 (E)2 (E)12.8 (R)2.6 ( C)2.6 (anc)-2 (er)-6 ( S)12.8 (t)-6.6 (at)-6.6 (i)2.6 (s)8.9 (t)-6.6 (i)2.6 (c)-2 (s)-2 ( )]TJ 0 -1.141 Td [(R)2.6 (ev)8.8 (i)2.6 (e)-11.2 (w)13.5 (,)-6.6 ( 1975)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 6.37 0 Td [(2015,)-6.6 ( bas)8.9 (ed on N)2.6 (ov)8.8 (em)-6 (ber)4.9 ( 2017 S)12.9 (E)1.9 (E)2 (R)2.6 ( dat)-6.6 (a )0.5 (s)-2.1 (ub)10.5 (m)-5.9 (i)2.6 (s)-2 (s)-2 (i)2.6 (on,)4.2 ( )]TJ -6.37 -1.152 Td [(pos)-2 (t)-6.6 (ed )11.3 (t)-6.6 (o )11.3 (t)-6.6 (he S)1.9 (E)2 (E)1.9 (R)2.7 ( w)13.4 (eb s)-1.9 (i)2.5 (t)-6.5 (e,)4.3 ( A)2 (pr)-6 (i)2.6 (l)2.6 ( 2018)10.5 (.)-6.6 ( B)2 (e)10.5 (t)-6.6 (hes)-2 (d)10.5 (a,)-6.6 ( M)15.8 (D)2.6 (:)-6.6 ( N)2.6 (at)-6.6 (i)2.6 (onal)2.7 ( C)2.7 (anc)-2 (er)4.9 ( )]TJ 0 -1.141 Td [(I)-6.6 (ns)-2 (t)-6.6 (i)2.7 (t)-6.7 (u)10.6 (t)-6.6 (e;)4.3 ( 2018)10.6 (.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.7 (e)-11.3 ( at)4.3 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.7 (t)-6.5 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (s)-2 (ee)10.5 (r)-6 (.)-6.6 (c)-2 (an)10.5 (c)-2 (er)4.9 (.)4.2 (gov)8.9 (/)-6.6 (c)-2 (s)-2 (r)-5.9 (/)-6.7 (1975_2015)10.5 (/)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 351.96 100.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 161.88 98.64 190.08 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 77.04 Tm [(8.)-6.7 ( S)2 (i)2.6 (e)10.5 (g)-11.2 (el)2.6 ( R)2.6 (L,)4.3 ( M)15.8 (i)2.6 (l)-8.3 (l)2.6 (er)-6 ( K)2 (D)2.6 (,)-6.6 ( J)8.9 (em)-5.9 (al)2.6 ( A)2 (.)4.2 ( C)2.6 (anc)-2 (er)4.9 ( s)-2 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (s)-2 (t)-6.6 (i)2.6 (c)-2 (s)8.9 (,)-6.6 ( 2018)10.5 (.)-6.6 ( C)2.6 (A)1.9 ( C)2.6 (anc)-2 (e)10.6 (r)-6 ( )11.3 (J)-2 ( )]TJ 0 -1.152 Td [(C)2.6 (l)2.6 (i)2.6 (n 2018;)-6.6 (68:)-6.6 (7)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 6.772 0 Td [(30)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -6.772 -1.141 Td [(h)6.7 (ttp)6.7 (s)15.9 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.)]TJ -0.002 Tc 0.002 Tw [(nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (29313949)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.76 51.72 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 49.68 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(9.)-6.7 ( A)12.9 (m)-6 (i)2.6 (n M)15.8 (B)1.9 (,)-6.6 ( E)2 (dg)-11.2 (e)10.5 ( S)2 (B)1.9 (,)-6.6 ( )11.3 (G)4.3 (r)-6 (eene F)11.2 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 (,)-6.6 ( ed)10.6 (s)-2 (.)4.2 ( A)2 (J)-2 (C)13.5 (C)2.6 ( C)2.6 (anc)-2 (er)-5.9 ( S)12.8 (t)-6.6 (a)10.5 (g)-11.2 (i)2.6 (ng )]TJ 0 -1.152 Td [(M)15.8 (anua)-11.2 (l)2.6 (,)-6.6 ( 8t)-6.6 (h e)10.5 (d.)4.2 ( )0.5 (N)2.6 (ew)13.5 ( Y)1.9 (or)-6 (k)-2 (:)-6.6 ( S)2 (p)10.5 (r)-5.9 (i)2.6 (ng)-11.2 (e)10.5 (r)-5.9 ( )11.2 (I)-6.6 (nt)-6.6 (e)10.5 (r)-5.9 (nat)-6.7 (i)2.7 (onal)2.6 ( )11.3 (P)2 (ubl)2.6 (i)2.6 (s)-2 (hi)2.6 (ng)-11.2 (;)-6.6 ( 2017)10.5 (.)]TJ 0 Tc 0 Tw 29.467 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -29.467 -2.141 Td [(10.)-6.6 ( J)-2 (on)10.6 (k)-12.9 (l)2.6 (aas)8.9 ( J)-2 (,)4.2 ( N)2.6 (o)10.6 (g)-11.2 (uer)-6 (a)10.5 (s)]TJ 0 Tc 0 Tw 11.25 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(G)-6.6 (onz)8.9 (al)2.6 (ez)8.9 ( G)-6.7 (,)4.3 ( M)15.8 (uns)-2 (el)2.7 (l)2.6 ( )-10.5 (M)15.8 (,)-6.6 ( et)-6.6 ( al)2.6 (.)-6.6 ( )11.2 (T)-10.5 (h)10.5 (e i)2.6 (m)-5.9 (pa)10.6 (c)-2 (t)4.2 ( o)10.6 (f)-6.7 ( a)10.6 (g)-11.3 (e)10.6 ( )]TJ -11.587 -1.141 Td [(and )11.2 (g)-11.2 (ender)4.9 ( on papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)]TJ 0 Tc 0 Tw 10.413 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(t)4.3 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)-5.9 ( s)-1.9 (u)10.5 (r)-6 (v)8.9 (i)2.6 (v)8.9 (a)-11.3 (l)2.7 (.)-6.7 ( J)-2 ( )11.3 (C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.7 (nol)2.6 ( M)15.8 (et)-6.6 (ab )]TJ 0.002 Tw -10.696 -1.152 Td [(2012;)-6.6 (97:)-6.6 (E)2 (878)]TJ 0 Tc 0 Tw 6.207 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(887.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.543 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22496497)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 439.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 437.64 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 416.04 Tm [(11.)-6.6 ( M)15.8 (az)-2 (z)8.9 (af)-17.4 (er)5 (r)-6 (i)2.6 ( E)2 (L,)4.3 ( J)-2 (hi)2.6 (an)10.5 (g S)2 (M)15.8 (.)-6.6 ( Long)]TJ 0 Tc 0 Tw (-)Tj -0.005 Tc 0.01 Tw 16.174 0 Td [(t)-9.6 (e)7.5 (r)-9 (m)1.9 ( im)-8.9 (p)-3.4 (a)-3.3 (c)5.8 (t)-9.6 ( )11.3 (o)7.5 (f)-20.5 ( in)-3.4 (it)-9.6 (ia)-3.3 (l s)-5.1 (u)-3.3 (r)1.9 (g)-14.2 (ic)-5 (a)-3.4 (l a)-3.3 (n)]TJ -0.013 Tc 0.013 Tw 13.967 0 Td (d )Tj -0.002 Tc 0.007 Tw -30.141 -1.152 Td [(m)-6 (edi)2.7 (c)-2 (al)2.6 ( t)-6.6 (he)10.5 (r)-6 (apy)8.9 ( on papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( and )11.3 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.7 (ar)-5.9 ( )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)-6 (.)4.3 ( A)1.9 (m)4.9 ( J)8.9 ( M)15.8 (ed )]TJ 0.002 Tw 0 -1.141 Td [(1994;)-6.6 (97:)-6.6 (418)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(428.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (7977430)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 378 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 375.96 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 354.36 Tm [(12.)-6.6 ( S)1.9 (t)4.3 (r)-5.9 (oup)10.5 ( A)1.9 (M)15.8 (,)-6.6 ( H)2.6 (ar)-6 (r)-5.9 (el)2.6 (l)2.6 ( C)2.6 (J)-2 (,)-6.6 ( H)2.7 (e)10.5 (r)4.9 (g)-11.2 (et)4.3 ( K)1.9 (A)2 (.)-6.6 ( Lon)10.5 (g)]TJ 0 Tc 0 Tw (-)Tj -0.013 Tc 0.007 Tw 19.62 0 Td [(t)-17.6 (er)-6.1 (m)-16.9 ( s)-13 (u)-11.3 (r)]TJ -0.002 Tc 3.652 0 Td [(v)8.9 (i)2.6 (v)8.8 (a)-11.2 (l)2.7 ( i)2.7 (n y)8.9 (oung)-11.2 ( )]TJ -23.272 -1.141 Td [(w)13.5 (om)-5.9 (en:)-6.6 ( haz)8.8 (ar)-5.9 (ds)-2 ( and)10.5 ( c)-2 (o)10.5 (m)-5.9 (pet)-6.6 (i)2.6 (n)10.5 (g)-11.2 ( )11.3 (r)-6 (i)2.6 (s)8.9 (k)-12.9 (s)8.9 ( a)10.5 (f)-6.6 (t)-6.6 (er)4.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (.)-6.6 ( )11.3 (J)-2 ( C)2.6 (anc)-2 (e)10.5 (r)-5.9 ( )]TJ 0 -1.141 Td [(E)2 (pi)2.6 (dem)-5.9 (i)2.6 (ol)2.7 ( 2012;)-6.5 (2012:)-6.6 (64)10.5 (1372.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 0 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (23091489)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 316.44 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 314.4 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 405 292.8 Tm [(13.)-6.6 ( I)-6.6 (t)-6.7 (o)10.6 ( )-10.6 (Y)1.9 (,)4.3 ( )-10.6 (H)2.6 (i)2.6 (g)-11.2 (as)-2 (hi)2.6 (y)8.9 (am)-5.9 (a T,)-6.6 ( T)-10.5 (a)]TJ 0.007 Tw 12.63 0 Td [(k)-12.9 (a)10.6 (m)-6 (ur)-5.9 (a)10.5 ( Y)2 (,)4.2 ( et)4.2 ( al)2.6 (.)4.3 ( Lon)10.5 (g)]TJ 0 Tc 0 Tw 9.478 0 Td (-)Tj -0.005 Tc -0.001 Tw 0.326 0 Td [(t)-9.6 (e)7.5 (r)-9 (m)1.9 ( f)-20.5 (o)-3.3 (llo)-3.4 (w)]TJ 0 Tc 0 Tw 4.804 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(up f)-17.5 (or)5 ( )]TJ 0.007 Tw -27.576 -1.141 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-6 (a )11.3 (t)-6.6 (r)4.9 (eat)-6.6 (ed)10.5 ( )11.3 (as)-2 ( beni)2.6 (g)-11.2 (n)10.5 ( nodul)2.6 (es)-2 (.)4.2 ( )]TJ 0 -1.152 Td [(A)2 (nt)-6.6 (i)2.6 (c)-2 (anc)-2 (er)-6 ( R)2.6 (es)8.9 ( 2007)10.5 (;)-6.6 (27:)4.3 (1039)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.467 0 Td [(1043.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -13.467 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (174)]TJ (65240)Tj EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 254.88 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 252.84 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 231.24 Tm [(14.)-6.6 ( Li)2.7 ( N)13.4 (,)-6.6 ( D)2.6 (u )11.3 (X)-9 (L)10.6 (,)-6.6 ( R)2.6 (ei)2.6 (t)-6.6 (z)8.9 (el)2.7 ( )11.2 (LR)2.6 (,)-6.6 ( et)4.3 ( al)2.6 (.)4.3 ( I)4.2 (m)-5.9 (pac)8.9 (t)-6.6 ( o)10.5 (f)-6.6 ( enha)10.6 (nc)-2 (ed det)-6.6 (ec)8.8 (t)-6.6 (i)2.6 (on on)10.5 ( t)-6.6 (he)10.5 ( )]TJ 0 -1.152 Td [(i)2.6 (nc)-2 (r)-6 (eas)-2 (e i)2.6 (n )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-6 ( i)2.7 (nc)-2 (i)2.6 (denc)-2 (e i)2.6 (n )11.3 (t)-6.7 (he U)2.7 (ni)2.6 (t)-6.6 (ed)10.5 ( )11.3 (S)1.9 (t)-6.6 (at)-6.7 (es)8.9 (:)-6.6 ( )11.2 (r)-5.9 (ev)8.9 (i)2.6 (e)-11.2 (w)13.5 ( of)-6.6 ( )]TJ 0 -1.141 Td [(i)2.6 (nc)-2 (i)2.6 (denc)-2 (e t)-6.6 (r)-6 (ends)8.9 ( by)8.9 ( s)-2 (oc)-2 (i)13.5 (oec)-2 (onom)-6 (i)2.6 (c)-2 ( s)8.9 (t)-6.6 (at)-6.6 (u)10.5 (s)-1.9 ( w)13.4 (i)2.6 (t)-6.6 (hi)2.6 (n )0.5 (t)-6.7 (he s)-2 (u)10.6 (r)-6 (v)8.9 (ei)2.6 (l)2.6 (l)2.7 (anc)-2 (e,)-6.6 ( )]TJ 0 -1.141 Td [(epi)2.6 (dem)-5.9 (i)2.6 (ol)2.6 (og)-11.2 (y)8.8 (,)-6.6 ( and end)10.5 ( r)4.9 (es)-2 (ul)2.6 (t)-6.6 (s)-2 ( )11.3 (r)-6 (e)10.6 (g)-11.2 (i)2.6 (s)-2 (t)-6.6 (r)-6 (y)8.9 (,)4.2 ( 19)]TJ 0.002 Tw (80)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 19.902 0 Td [(200)10.5 (8.)-6.6 ( T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )-10.7 (2013)10.5 (;)-6.6 (23:)-6.6 (103)]TJ 0 Tc 0 Tw 11.902 0 Td (-)Tj -0.002 Tc 0.007 Tw -31.804 -1.152 Td [(110.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.2 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.7 (h.)-6.6 (g)-11.2 (ov)8.9 (/)-6.6 (pu)10.5 (bm)-5.9 (ed/)-6.6 (23043274)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 721.2 180.6 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 492.6 178.56 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 156.96 Tm [(15.)-6.6 ( D)2.6 (av)8.8 (i)2.6 (es)-2 ( L,)-6.6 ( )33 (W)-36.2 (e)10.5 (l)2.6 (c)-2 (h H)13.4 (G)-6.6 (.)4.3 ( C)2.6 (ur)-6 (r)-6 (en)10.5 (t)-6.6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2.1 (anc)-2 (e)10.5 (r)-6 ( )11.3 (t)-6.6 (r)4.9 (ends)-2 ( i)2.6 (n t)-6.6 (he)10.5 ( U)2.6 (ni)2.7 (t)-6.7 (ed)10.5 ( )]TJ 0 -1.141 Td [(S)2 (t)-6.7 (at)-6.6 (es)8.9 (.)-6.6 ( J)-2 (A)2 (M)15.7 (A)2 ( O)-6.6 (t)-6.6 (ol)2.7 (a)10.5 (r)-6 (y)8.9 (ngol)2.6 ( H)2.6 (ead N)2.6 (ec)8.9 (k)-12.9 ( )]TJ [(S)1.9 (u)10.6 (r)4.9 (g)-11.2 ( 2014)10.5 (;)-6.6 (140:)-6.6 (317)]TJ 0 Tc 0 Tw 25.37 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(322.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e )]TJ -0.006 Tc 0.006 Tw -25.707 -1.152 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (24557566)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 648.96 131.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 420.36 129.6 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 108 Tm [(16.)-6.6 ( )33 (W)-36.3 (i)2.7 (l)2.6 (hel)2.6 (m)4.9 ( S)1.9 (.)4.3 ( E)2 (v)8.8 (al)2.6 (uat)-6.6 (i)2.6 (o)-11.2 (n o)10.6 (f)-6.6 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d i)2.6 (nc)-2 (i)2.6 (dent)-6.7 (al)2.6 (om)4.9 (a.)-6.6 ( S)2 (ur)4.9 (g C)2.6 (l)2.6 (i)2.6 (n N)2.6 (or)-5.9 (t)-6.6 (h)10.5 ( A)2 (m)4.9 ( )]TJ 0.002 Tw 0 -1.141 Td [(2014;)-6.6 (94:)-6.6 (485)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(497.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24857572)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 82.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 80.64 228.72 0.84 re f EMC endstream endobj 905 0 obj 25438 endobj %% Contents for page 102 %% Original object ID: 205 0 906 0 obj << /Length 907 0 R >> stream Q q BT /Xi100 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 907 0 obj 246 endobj %% Original object ID: 11462 0 908 0 obj [ 2675 0 R 2676 0 R 2677 0 R 2678 0 R 2679 0 R 2680 0 R 2681 0 R 2682 0 R 2683 0 R 2684 0 R 2685 0 R 2686 0 R 2687 0 R 2688 0 R 2689 0 R 2690 0 R ] endobj %% Contents for page 103 %% Original object ID: 206 0 909 0 obj << /Length 910 0 R >> stream q endstream endobj 910 0 obj 2 endobj %% Contents for page 103 %% Original object ID: 11463 0 911 0 obj << /Length 912 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (40)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(17.)-6.6 ( D)2.6 (av)8.8 (i)2.6 (es)-2 ( L,)-6.6 ( )33 (W)-36.2 (e)10.5 (l)2.6 (c)-2 (h H)13.4 (G)-6.6 (.)4.3 ( I)-6.6 (nc)8.9 (r)-6 (eas)-2 (i)2.6 (n)10.5 (g)-11.2 ( i)2.6 (nc)-2 (i)2.6 (denc)-2 (e o)10.5 (f)-6.6 ( )11.2 (t)4.3 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)-5.9 ( i)2.6 (n )11.2 (t)-6.6 (he )]TJ 0 -1.152 Td [(U)2.6 (ni)2.6 (t)-6.6 (ed S)1.9 (t)-6.6 (at)-6.6 (e)10.5 (s)-2 (,)4.2 ( 1973)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.098 0 Td [(200)10.5 (2.)-6.6 ( J)-2 (A)1.9 (M)15.8 (A)2 ( 2006;)-6.6 (295:)-6.6 (2164)]TJ 0 Tc 0 Tw 12.348 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(2167.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -21.772 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (16684987)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 488.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 486.6 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 465 Tm [(18.)-6.6 ( )11.3 (I)-6.6 (t)-6.7 (o)10.6 ( Y)1.9 (,)4.3 ( )11.3 (T)-10.6 (om)-5.9 (oda)10.5 ( C)2.6 (,)4.3 ( U)2.6 (r)-6 (u)10.6 (no )11.2 (T)-10.5 (,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( P)2 (api)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( )0.5 (m)-6 (i)2.6 (c)-2 (r)4.9 (oc)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.5 ( )0.5 (o)10.5 (f)-6.6 ( t)-6.7 (he)10.5 ( )]TJ 0 -1.152 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d:)-6.6 ( how)13.4 ( s)-1.9 (houl)2.6 (d i)2.6 (t)-6.6 ( be)10.5 ( )11.3 (t)-6.6 (r)-5.9 (ea)10.5 (t)-6.6 (ed? )33 (W)-36.3 (o)10.5 (r)-5.9 (l)2.6 (d J)8.9 ( S)2 (ur)4.9 (g 20)10.6 (04;)-6.6 (28:)-6.6 (1115)]TJ 0 Tc 0 Tw 27.087 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(1121.)4.3 ( )]TJ 0.007 Tw -27.424 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (15490053)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 439.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 437.64 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 416.04 Tm [(19.)-6.6 ( V)1.9 (er)4.9 (g)-11.2 (a)10.5 (m)-5.9 (i)2.6 (ni)2.7 ( LB)2 (,)4.2 ( Fr)-5.9 (az)8.9 (i)2.6 (er)-6 ( A)1.9 (L,)4.3 ( A)2 (br)-6 (an)10.5 (t)-6.6 (es)8.9 ( FL,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( )11.3 (I)4.2 (nc)-2 (r)-6 (eas)-2 (e i)2.6 (n)10.5 ( t)-6.6 (he)10.6 ( i)2.6 (nc)-2 (i)2.6 (denc)-2 (e )]TJ 0 -1.152 Td [(o)10.5 (f)-17.5 ( di)13.5 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( )0.5 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)8.9 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a i)2.6 (n)10.5 ( c)-2 (hi)2.6 (l)2.6 (dr)-6 (en,)4.3 ( ad)10.6 (ol)2.6 (es)-2 (c)-2 (ent)-6.6 (s)-2 (,)4.2 ( and y)8.8 (oun)10.5 (g)-11.2 ( )]TJ 0 -1.141 Td [(adul)2.6 (t)-6.6 (s)-2 (:)-6.6 ( a)10.5 ( popul)2.6 (at)-6.6 (i)2.7 (on)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 8.989 0 Td [(ba)10.5 (s)8.8 (ed s)-2.1 (t)-6.6 (udy)]TJ 5.359 0 Td [(.)4.3 ( J)-2 ( P)1.9 (edi)2.6 (at)4.2 (r)-5.9 ( 2014)10.6 (;)4.2 (164:)-6.6 (1481)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 11.75 0 Td [(1485)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)-8.3 (e )]TJ -0.006 Tc 0.006 Tw -26.098 -1.152 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (24630354)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 267.48 378 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 38.88 375.96 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 354.36 Tm [(20.)-6.6 ( B)1.9 (ann)10.5 ( D)2.6 (V)1.9 (,)-6.6 ( )11.3 (G)-6.6 (oy)8.9 (al)2.6 ( N)2.6 (,)-6.6 ( C)13.4 (am)-5.9 (ac)-2 (ho F)11.2 (,)-6.6 ( )11.2 (G)-6.6 (ol)2.6 (denber)4.9 (g )11.3 (D)2.6 (.)-6.6 ( I)-6.6 (n)10.5 (c)-2 (r)-5.9 (eas)-2 (i)2.6 (n)10.5 (g)-11.2 ( i)2.6 (nc)-2 (i)2.7 (denc)-2 (e)10.5 ( )]TJ 0 -1.141 Td [(o)10.5 (f)-17.5 ( )11.3 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 ( i)2.6 (n )11.3 (t)-6.6 (he C)13.5 (om)-5.9 (m)-6 (onw)13.5 (eal)2.6 (t)-6.6 (h)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 17.565 0 Td [(o)10.5 (f)-6.6 ( P)2 (enns)-2 (y)8.9 (l)2.6 (v)8.9 (an)-11.2 (i)2.6 (a.)-6.6 ( J)-2 (A)1.9 (M)15.8 (A)2 ( )]TJ -17.565 -1.141 Td [(O)-6.6 (t)-6.6 (ol)2.6 (ar)-6 (y)8.9 (n)10.5 (g)-11.2 (ol)2.6 ( H)2.6 (ead N)2.7 (ec)8.9 (k)-2 ( )11.2 (S)2 (ur)-6 (g 2014;)-6.6 (1)10.5 (40:)-6.6 (1149)]TJ 0 Tc 0 Tw 19.609 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(115)10.5 (6.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -19.946 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (25170647)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 316.44 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 314.4 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 292.8 Tm [(21.)-6.6 ( A)1.9 (s)-1.9 (c)-2.1 (heb)10.5 (r)-6 (oo)10.5 (k)]TJ 0 Tc 0 Tw 6.935 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(K)2 (i)2.6 (l)13.4 (f)-17.4 (oy)8.9 ( B)1.9 (,)4.3 ( K)2 (apl)2.6 (an E)1.9 (L,)4.2 ( C)2.7 (hi)2.6 (u B)1.9 (C)2.6 (,)-6.6 ( e)10.6 (t)-6.6 ( )11.2 (al)2.6 (.)-6.6 ( )11.2 (T)-10.5 (he ac)8.9 (c)-2 (el)2.7 (er)-5.9 (at)-6.6 (i)2.6 (on i)2.6 (n)10.5 ( )]TJ -7.272 -1.141 Td [(papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)-6 ( i)13.5 (nc)-2 (i)2.6 (denc)-2 (e r)-6 (a)10.6 (t)-6.7 (es)-2 ( i)2.6 (s)8.9 ( s)-2 (i)2.6 (m)-6 (i)2.6 (l)2.6 (ar)-6 ( )11.3 (am)-6 (on)10.5 (g)-11.2 ( )11.2 (r)-5.9 (ac)-2 (i)2.6 (al)2.6 ( and e)10.6 (t)-6.6 (hni)2.6 (c)-2 ( )]TJ 0 -1.152 Td [(g)-11.2 (r)4.9 (oups)-2 ( i)2.6 (n )11.3 (t)-6.6 (he U)2.6 (ni)2.7 (t)-6.7 (e)10.6 (d S)2 (t)-6.6 (a)10.5 (t)4.3 (es)-2 (.)-6.6 ( A)2 (nn)10.5 ( S)2 (ur)5 (g O)-6.6 (nc)-2 (ol)13.5 ( 201)10.5 (3;)-6.7 (20:)-6.7 (2746)]TJ 0 Tc 0 Tw 25.978 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(2753.)4.3 ( )]TJ 0.007 Tw -26.315 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (23504142)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 254.88 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 252.84 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 231.24 Tm [(22.)-6.6 ( S)1.9 (c)-1.9 (hnei)2.6 (der)5 ( D)2.7 (F,)4.2 ( E)2 (l)13.5 (f)-17.5 (en)10.5 (bei)2.6 (n D)2.6 (,)-6.6 ( Ll)2.6 (oy)8.9 (d R)2.6 (V)1.9 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( L)10.6 (y)8.8 (m)-5.9 (ph node )11.3 (m)-6 (et)-6.7 (as)8.9 (t)-6.6 (as)-2 (es)8.8 ( )]TJ 0 -1.152 Td [(do not)4.3 ( i)2.6 (m)-6 (pac)8.9 (t)-6.6 ( s)-2 (u)10.5 (r)-5.9 (v)8.8 (i)2.6 (v)8.9 (a)-11.2 (l)2.6 ( i)2.6 (n f)-6.7 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( v)8.9 (ar)-5.9 (i)2.6 (ant)-6.6 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)-1.9 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-5.9 (.)4.3 ( A)1.9 (nn )]TJ -0.004 Tw 0 -1.141 Td [(S)2 (ur)-5.9 (g O)-6.6 (nc)-2 (ol)2.6 ( )-10.6 (2015)10.6 (;)-6.6 (22:)-6.6 (158)]TJ 0 Tc 0 Tw 10.804 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(163.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -11.141 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)]TJ -0.002 Tc 0.002 Tw 3.935 0 Td [(w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.8 (/)-6.6 (pubm)-6 (ed/)-6.6 (25092163)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 193.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 191.28 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 23.52 169.68 Tm [(23.)-6.6 ( )22 (W)-36.3 (a)10.6 (n)10.5 (g)-11.2 ( T)-10.5 (S)12.8 (,)-6.6 ( G)-6.5 (o)10.5 (f)-6.6 (f)-6.6 (r)-6 (edo)10.5 ( P)2 (,)-6.7 ( )-10.6 (S)2 (os)-2.1 (a J)-2 (A)1.9 (,)4.3 ( )-10.6 (R)2.6 (om)-5.9 (an)10.6 ( )-10.6 (S)1.9 (A)2 (.)-6.6 ( P)2 (api)2.6 (l)2.6 (l)2.6 (ar)-16.8 (y)8.8 ( )-10.6 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d )]TJ 0.007 Tw 0 -1.152 Td [(m)-6 (i)2.7 (c)-2 (r)-6 (oc)-2 (a)10.5 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (:)-6.6 ( an)10.5 ( ov)8.9 (er)]TJ 0 Tc 0 Tw 10.913 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(t)-6.6 (r)-6 (e)10.6 (at)-6.6 (ed)10.5 ( m)-6 (al)2.6 (i)13.5 (g)-11.2 (nanc)-2 (y)8.9 (? )22.2 (W)-36.3 (o)21.4 (r)-6 (l)2.6 (d J)-2 ( S)2 (u)10.5 (r)4.9 (g)-11.2 ( )]TJ 0.002 Tw -11.25 -1.141 Td [(2014;)-6.6 (38:)-6.6 (2297)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(2303.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -6.435 -1.152 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)]TJ -0.002 Tc 0.002 Tw 3.217 0 Td [(w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.7 (m)-6 (.)-6.6 (ni)2.7 (h.)4.3 (gov)8.8 (/)-6.6 (pubm)-6 (ed/)-6.6 (24791670)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 131.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 129.6 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 108 Tm [(24.)-6.6 ( A)1.9 (s)-1.9 (c)-2.1 (heb)10.5 (r)-6 (oo)10.5 (k)]TJ 0 Tc 0 Tw 6.935 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(K)2 (i)2.6 (l)13.4 (f)-17.4 (oy)8.9 ( B)1.9 (,)4.3 ( G)4.3 (r)-6 (o)10.5 (g)-11.2 (an R)2.6 (H)2.6 (,)4.3 ( )22.1 (W)-36.2 (a)10.5 (r)4.9 (d M)15.8 (H)2.6 (,)-6.7 ( )11.3 (et)-6.6 ( al)2.6 (.)4.3 ( Fol)2.6 (l)2.7 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d )]TJ -7.272 -1.141 Td [(c)-2 (anc)-2 (er)-6 ( i)2.6 (nc)-2 (i)2.6 (denc)-2 (e)10.6 ( pat)4.2 (t)-6.6 (er)-6 (n)10.5 (s)-2 ( i)2.6 (n t)-6.6 (he)10.6 ( U)2.6 (ni)2.6 (t)-6.6 (ed S)12.9 (t)-6.7 (at)-6.6 (e)10.5 (s)-2 (,)4.3 ( 1)10.5 (980)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 23.435 0 Td [(2009.)4.3 ( T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0.002 Tw -23.435 -1.152 Td [(2013;)-6.6 (23:)-6.6 (1015)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1021.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (23360496)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 70.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 68.04 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(25.)-6.6 ( A)1.9 (s)-1.9 (c)-2.1 (heb)10.5 (r)-6 (oo)10.5 (k)]TJ 0 Tc 0 Tw 6.935 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(K)2 (i)2.6 (l)13.4 (f)-17.4 (oy)8.9 ( B)1.9 (,)4.3 ( )22.1 (W)-36.2 (a)10.5 (r)4.9 (d M)15.8 (H)2.6 (,)-6.6 ( S)1.9 (abr)-5.9 (a M)15.8 (M)15.8 (,)-6.6 ( D)2.6 (ev)8.9 (es)-2 (a S)2 (S)1.9 (.)-6.6 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ -7.272 -1.152 Td [(c)-2 (anc)-2 (er)-6 ( i)2.6 (nc)-2 (i)2.6 (denc)-2 (e)10.6 ( pat)4.2 (t)-6.6 (er)-6 (n)10.5 (s)-2 ( i)2.7 (n t)-6.6 (he)10.6 ( U)2.6 (ni)2.6 (t)-6.6 (ed S)12.9 (t)-6.7 (at)-6.6 (e)10.5 (s)-2 ( by)8.8 ( )11.3 (hi)2.6 (s)-2 (t)-6.6 (ol)2.6 (og)-11.3 (i)2.7 (c)-2 ( )11.2 (t)-6.6 (y)8.9 (pe,)-6.6 ( 1992)]TJ 0 Tc 0 Tw 31.022 0 Td (-)Tj -0.002 Tc -0.004 Tw -31.022 -1.141 Td [(2006.)-6.6 ( T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )-10.6 (2011)10.6 (;)-6.6 (21:)-6.6 (1)10.5 (25)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 12.25 0 Td [(134.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -12.25 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21186939)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 473.88 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 452.28 Tm [(26.)-6.6 ( Y)1.9 (u )11.3 (G)-6.6 (P)12.8 (,)-6.6 ( Li)2.7 ( J)-2 (C)13.5 (,)-6.6 ( B)12.8 (r)-5.9 (ano)10.5 (v)8.9 (an D)2.6 (,)-6.6 ( et)4.3 ( al)2.6 (.)-6.6 ( )11.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (an)10.5 (c)-2 (er)-6 ( i)2.6 (nc)-2 (i)2.6 (denc)-2 (e and)10.5 ( s)-2 (u)10.5 (r)-5.9 (v)8.9 (i)2.6 (v)-2 (al)2.6 ( )]TJ 0 -1.141 Td [(i)2.6 (n t)-6.6 (he na)10.5 (t)-6.6 (i)2.6 (onal)2.6 ( c)-2 (anc)-2 (e)10.5 (r)-5.9 ( i)2.6 (ns)8.9 (t)-6.6 (i)2.6 (t)-6.6 (ut)-6.5 (e)10.5 ( s)-2 (ur)-5.9 (v)8.8 (ei)2.6 (l)2.6 (l)2.6 (anc)-2 (e,)-6.6 ( epi)2.6 (dem)-6 (i)2.6 (ol)2.6 (og)-11.3 (y)8.9 (,)-6.6 ( and)10.5 ( end )11.3 (r)-6 (es)-2.1 (ul)2.6 (t)-6.6 (s)8.9 ( )]TJ 0 -1.152 Td [(r)-6 (ac)-2 (e/)-6.6 (e)10.6 (t)-6.6 (hni)2.6 (c)-2 (i)2.6 (t)-6.6 (y)8.9 ( gr)-6 (o)]TJ -0.004 Tw [(ups)8.9 (.)-6.6 ( T)-10.5 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d )-10.6 (2010;)-6.6 (20:)-6.6 (465)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 19.228 0 Td [(473.)4.2 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -19.228 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (20384488)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 412.32 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 390.72 Tm [(27.)-6.6 ( C)2.6 (hen A)1.9 (Y)12.9 (,)-6.7 ( J)-2 (e)10.6 (m)-6 (al)2.6 ( A)12.8 (,)-6.6 ( )11.3 (W)-25.5 (a)10.6 (r)4.9 (d)10.5 ( E)2 (M)15.8 (.)-6.7 ( I)-6.6 (nc)-2 (r)-6 (eas)-2.1 (i)2.6 (n)10.6 (g i)2.6 (nc)-2 (i)2.6 (denc)-2 (e o)10.5 (f)-6.6 ( di)13.4 (f)-6.6 (f)-6.6 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )]TJ 0 -1.152 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 ( i)2.7 (n t)-6.6 (he)10.5 ( U)2.6 (ni)2.6 (t)4.3 (ed S)2 (t)-6.6 (at)4.3 (es)-2 (,)4.3 ( )]TJ 0.002 Tw (1988)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 18.348 0 Td [(2005)10.5 (.)-6.6 ( C)13.4 (anc)-2 (er)-5.9 ( 2009)10.5 (;)-6.6 (115:)-6.6 (3801)]TJ 0 Tc 0 Tw 12.902 0 Td (-)Tj -0.002 Tc 0.007 Tw -31.25 -1.141 Td [(3807.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.3 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.7 (nc)-2 (bi)2.6 (.)-6.7 (nl)2.6 (m)-5.9 (.)-6.7 (ni)2.6 (h.)-6.6 (g)-11.3 (ov)8.9 (/)-6.7 (pu)10.5 (bm)-6 (ed/)-6.6 (19598221)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 727.32 365.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 498.72 363.36 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 341.76 Tm [(28.)-6.6 ( E)1.9 (new)13.4 (ol)2.6 (d L,)-6.6 ( Zhu)10.6 ( K)1.9 (,)4.3 ( R)2.6 (on E)1.9 (,)-6.6 ( )0.5 (e)10.5 (t)4.2 ( al)2.6 (.)-6.6 ( R)2.6 (i)2.6 (s)-2 (i)2.6 (n)10.5 (g)-11.2 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )0.5 (c)-2 (anc)-2 (er)4.9 ( i)2.6 (nc)-2 (i)2.6 (denc)-2 (e i)2.6 (n )11.2 (t)-6.6 (he )]TJ 0 -1.141 Td [(U)2.6 (ni)2.6 (t)-6.6 (ed S)1.9 (t)-6.6 (at)-6.6 (e)10.5 (s)-2 ( by)8.9 ( de)10.5 (m)-6 (o)10.5 (g)-11.2 (r)5 (a)]TJ [(phi)2.6 (c)-2 ( and t)-6.6 (u)10.5 (m)-6 (o)10.6 (r)-6 ( c)-2 (ha)10.6 (r)-6 (ac)8.8 (t)4.3 (er)-5.9 (i)2.6 (s)-2 (t)-6.6 (i)2.6 (c)-2 (s)-2 (,)4.3 ( 1980)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 27.87 0 Td [(2005)10.5 (.)-6.6 ( )]TJ 0.007 Tw -27.87 -1.152 Td [(C)2.6 (anc)-2 (er)-6 ( E)2 (pi)2.6 (dem)-5.9 (i)2.6 (ol)2.7 ( B)1.9 (i)2.6 (om)-6 (a)10.5 (r)4.9 (k)-12.8 (er)-5.9 (s)8.9 ( P)2 (r)-6 (ev)8.9 ( 2009;)-6.6 (18)10.5 (:)-6.6 (784)]TJ 0 Tc 0 Tw 21.326 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(791.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -21.652 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19240234)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 303.84 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 301.8 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 280.2 Tm [(29.)-6.6 ( H)2.6 (ow)13.4 (l)2.6 (ader)-5.9 ( N)2.7 (,)-6.6 ( N)2.6 (oone)10.5 ( )11.3 (A)2 (,)-6.7 ( )0.5 (K)1.9 (r)-6 (apc)-2 (ho)10.5 ( M)15.8 (,)-6.6 ( et)4.2 ( al)2.6 (.)-6.6 ( S)]TJ -0.005 Tc 0.01 Tw 20.337 0 Td [(E)-1 (E)9.8 (R Ca)-3.4 (n)-3.4 (c)-5 (e)-3.3 (r)-9 ( S)9.8 (t)-9.6 (a)-3.3 (t)-9.6 (is)5.8 (t)-9.6 (ic)-5 (s)-5 ( )]TJ -0.002 Tc 0.007 Tw -20.337 -1.152 Td [(R)2.6 (ev)8.8 (i)2.6 (e)-11.2 (w)13.5 (,)-6.6 ( 1975)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 6.37 0 Td [(2014,)-6.6 ( bas)8.9 (ed on N)2.6 (ov)8.9 (em)-6 (ber)4.9 ( 2016 S)12.9 (E)1.9 (E)2 (R)2.6 ( dat)-6.6 (a s)-2 (ub)10.5 (m)-5.9 (i)2.6 (s)-2 (s)-2 (i)2.6 (on,)4.2 ( )]TJ -6.37 -1.141 Td [(pos)-2 (t)-6.6 (ed )11.3 (t)-6.6 (o )11.3 (t)-6.6 (he S)1.9 (E)2 (E)1.9 (R)2.7 ( w)13.4 (eb s)-2 (i)2.7 (t)-6.6 (e,)4.3 ( A)2 (pr)-6 (i)2.6 (l)2.6 ( 2017)10.5 (.)-6.6 ( B)2 (e)10.5 (t)-6.6 (hes)-2 (d)10.5 (a,)-6.6 ( M)15.8 (D)2.6 (:)-6.6 ( N)2.6 (at)-6.6 (i)2.6 (onal)2.7 ( C)2.7 (anc)-2 (er)4.9 ( )]TJ 0 -1.152 Td [(I)-6.6 (ns)-2 (t)-6.6 (i)2.7 (t)-6.7 (u)10.6 (t)-6.6 (e;)4.3 ( 2017)10.6 (.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.7 (e)-11.3 ( at)4.3 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw [(h)17.6 (ttp)6.6 (s)15.9 (:/)11.3 (/s)4.9 (e)6.7 (e)17.5 (r)1.1 (.)]TJ -0.002 Tc 0.002 Tw [(c)-2 (an)10.6 (c)-2 (er)4.9 (.)4.3 (gov)8.9 (/)-6.6 (c)-2 (s)-2 (r)-6 (/)-6.6 (1975_2014)10.5 (/)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 733.44 242.16 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 543.36 240.12 190.08 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 218.52 Tm [(30.)-6.6 ( S)1.9 (i)2.7 (e)10.5 (g)-11.2 (el)2.6 ( R)2.6 (,)4.3 ( )22.1 (W)-36.2 (a)10.5 (r)4.9 (d E)12.8 (,)-6.6 ( B)1.9 (r)4.9 (aw)2.6 (l)2.6 (ey)8.8 ( O)-6.6 (,)-6.6 ( J)-2 (e)10.5 (m)-5.9 (al)2.7 ( A)2 (.)4.3 ( C)2.6 (anc)8.8 (er)-5.9 ( s)8.9 (t)-6.6 (at)-6.6 (i)2.6 (s)8.8 (t)-6.6 (i)2.6 (c)-2 (s)-2 (,)4.3 ( 2011:)4.3 ( t)-6.6 (he)10.5 ( )]TJ 0 -1.141 Td [(i)2.6 (m)-5.9 (pac)-2 (t)4.2 ( o)10.5 (f)-6.6 ( el)2.6 (i)2.6 (m)-6 (i)2.7 (nat)-6.6 (i)2.6 (ng s)-2 (oc)8.9 (i)2.6 (oec)-2 (onom)-6 (i)2.6 (c)-2 ( and )11.3 (r)-6 (ac)-2 (i)2.7 (al)2.6 ( di)13.5 (s)-2 (par)-6 (i)2.6 (t)-6.6 (i)2.6 (es)-2 ( on)10.5 ( pr)-6 (e)10.6 (m)-6 (at)-6.6 (u)10.6 (r)-6 (e )]TJ 0 -1.141 Td [(c)-2 (anc)-2 (er)-6 ( dea)10.5 (t)-6.6 (hs)8.9 (.)-6.7 ( C)2.7 (A)1.9 ( C)2.6 (anc)8.9 (er)-5.9 ( J)8.9 ( C)2.7 (l)2.6 (i)2.6 (n 2011;)-6.6 (61:)-6.6 (2)10.6 (12)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 20.62 0 Td [(23)10.5 (6.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -20.62 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21685461)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 180.6 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 178.56 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 156.96 Tm [(31.)-6.6 ( U)2.6 (.)-6.6 (S)12.8 (.)-6.6 ( N)2.6 (a)10.6 (t)-6.7 (i)2.7 (onal)2.6 ( Li)2.6 (br)-5.9 (ar)-5.9 (y)8.8 ( o)10.6 (f)-6.6 ( M)15.8 (edi)2.6 (c)-2 (i)2.7 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 16.554 0 Td [(K)2 (e)-11.3 (y)8.9 ( )-10.5 (M)15.8 (E)2 (D)2.6 (LI)-6.6 (N)2.6 (E)2 -4.1 ( I)-6.6 (ndi)2.6 (c)-2 (a)10.5 (t)-6.6 (or)-6 (s)8.9 (.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)-8.3 (e )]TJ -0.006 Tc 0.006 Tw -16.554 -1.141 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)-6.6 (g)-11.2 (o)10.5 (v)8.8 (/)-6.6 (bs)-2 (d/)-6.7 (bs)-2 (d_)10.6 (k)-12.9 (ey)8.8 (.)-6.6 (ht)4.2 (m)-5.9 (l)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0.005 Tc -0.005 Tw 11.04 -0 0 11.04 619.68 144.36 Tm (. )Tj -0.002 Tc 0.007 Tw 0.565 0 Td [(A)2 (c)8.8 (c)8.9 (es)-1.9 (s)-2 (ed M)15.7 (ar)-6 (c)-1.9 (h 9,)4.2 ( 2018.)]TJ 0 Tc 0 Tw 11.228 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 420.36 142.32 199.319 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 120.72 Tm [(32.)-6.6 ( M)15.8 (al)2.6 (l)2.7 (i)2.6 (c)-2 (k)-12.9 ( U)2.6 (,)-6.6 ( H)2.6 (a)10.5 (r)-5.9 (m)-6 (e)10.5 (r)-5.9 ( C)13.4 (,)4.3 ( Y)2 (ap B)1.9 (,)4.3 ( et)4.3 ( al)2.7 (.)4.2 ( A)2 (bl)2.6 (at)-6.6 (i)2.6 (on w)13.5 (i)2.6 (t)-6.6 (h l)2.6 (ow)]TJ 0 Tc 0 Tw 24.239 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(dos)-2 (e r)-6 (adi)2.6 (oi)2.6 (odi)2.6 (ne )]TJ -24.576 -1.152 Td [(and t)-6.7 (hy)8.9 (r)-6 (ot)4.2 (r)-5.9 (opi)2.6 (n al)13.5 (f)-17.5 (a)10.5 ( i)2.6 (n t)-6.6 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)-6 (.)4.3 ( N)2.6 ( E)1.9 (n)10.6 (g)-11.2 (l)2.6 ( J)8.8 ( M)4.9 (ed )0.5 (2012;)-6.7 (366)10.6 (:)-6.6 (1674)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 29.935 0 Td [(1685)10.5 (.)4.2 ( )]TJ 0.007 Tw -29.935 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw [(h)17.6 (ttp)17.5 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.)]TJ -0.002 Tc 0.002 Tw [(nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.2 (g)-11.2 (ov)8.8 (/)-6.6 (pub)10.6 (m)-6 (ed)10.5 (/)-6.6 (22551128)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 95.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 93.36 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 71.76 Tm [(33.)-6.6 ( S)1.9 (c)-1.9 (hl)2.6 (um)-6 (be)10.5 (r)4.9 (g)-11.2 (er)5 ( M)15.7 (,)-6.6 ( C)2.6 (at)4.3 (ar)4.9 (g)-11.2 (i)2.6 ( B)2 (,)4.2 ( B)2 (or)4.9 (g)-11.2 (et)4.2 ( )11.3 (I)-6.6 (,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( S)12.9 (t)-6.7 (r)5 (at)-6.6 (e)10.5 (g)-11.2 (i)2.6 (es)-2 ( o)10.5 (f)-6.6 ( r)-6 (adi)2.6 (oi)2.6 (odi)2.6 (ne )]TJ 0 -1.152 Td [(abl)2.6 (at)-6.6 (i)2.6 (on i)2.6 (n pat)-6.6 (i)2.7 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h l)2.6 (ow)]TJ 0 Tc 0 Tw 12.12 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(r)-6 (i)2.7 (s)-2 (k)-12.9 ( )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (.)4.3 ( N)2.6 ( E)1.9 (ng)-11.2 (l)13.4 ( J)-2 ( M)15.8 (ed )]TJ EMC ET endstream endobj 912 0 obj 27857 endobj %% Contents for page 103 %% Original object ID: 207 0 913 0 obj << /Length 914 0 R >> stream Q q BT /Xi101 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 914 0 obj 246 endobj %% Original object ID: 11480 0 915 0 obj [ 2691 0 R 2692 0 R 2693 0 R 2694 0 R 2695 0 R 2696 0 R 2697 0 R 2698 0 R 2699 0 R 2700 0 R 2701 0 R 2702 0 R 2703 0 R 2704 0 R 2705 0 R 2706 0 R ] endobj %% Contents for page 104 %% Original object ID: 208 0 916 0 obj << /Length 917 0 R >> stream q endstream endobj 917 0 obj 2 endobj %% Contents for page 104 %% Original object ID: 11481 0 918 0 obj << /Length 919 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (41)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(2012;)-6.6 (366:)-6.6 (1663)]TJ 0 Tc 0 Tw 6.652 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1673.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.989 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22551127)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 499.2 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 477.6 Tm [(34.)-6.6 ( S)1.9 (her)4.9 (m)-6 (an)10.5 ( S)1.9 (I)4.3 (.)-6.6 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )11.2 (c)-2 (ar)-6 (c)-1.9 (i)2.6 (nom)-6 (a)10.5 (.)-6.6 ( Lanc)-2 (e)10.5 (t)-6.6 ( 2)10.5 (003;)4.2 (361:)-6.6 (501)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 25.935 0 Td [(511)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e )]TJ -0.006 Tc 0.006 Tw -25.935 -1.141 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (12583960)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 267.48 465 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 38.88 462.96 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 441.36 Tm [(35.)-6.6 ( P)1.9 (el)2.6 (l)2.6 (egr)-5.9 (i)2.6 (t)-6.6 (i)2.6 ( )11.3 (G)-6.6 (,)4.2 ( Fr)-6 (as)]TJ 9.087 0 Td [(c)-2 (a F)11.1 (,)-6.6 ( R)2.6 (e)10.5 (g)-11.2 (al)2.6 (but)-6.6 (o)10.5 ( C)2.6 (,)-6.6 ( )11.3 (et)4.3 ( al)2.7 (.)-6.7 ( )33 (W)-36.2 (o)10.5 (r)4.9 (l)2.6 (d)-11.2 (w)13.5 (i)2.6 (de i)2.6 (nc)-2 (r)-6 (eas)-2 (i)2.6 (ng)-11.2 ( )]TJ -9.087 -1.152 Td [(i)2.6 (nc)-2 (i)2.6 (denc)-2 (e o)10.5 (f)-17.5 ( )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)8.9 (er)-6 (:)4.3 ( updat)-6.6 (e)10.5 ( on epi)2.6 (de)10.5 (m)-5.9 (i)2.6 (ol)2.6 (og)-11.2 (y)8.8 ( and )11.3 (r)-6 (i)2.6 (s)8.9 (k)-12.9 ( )11.3 (f)-6.6 (ac)-2 (t)-6.6 (o)10.6 (r)-6 (s)8.9 (.)-6.6 ( J)8.9 ( )]TJ 0 -1.141 Td [(C)2.6 (anc)-2 (er)-6 ( E)2 (pi)2.6 (dem)-5.9 (i)2.6 (ol)2.7 ( 2013)10.5 (;)4.3 (2013:)-6.6 (965212.)4.3 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e )-10.5 (at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 0 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)]TJ 12.402 0 Td [(pubm)-6 (ed/)-6.6 (23737785)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 403.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 401.28 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 379.68 Tm [(36.)-6.6 ( )33 (W)-36.3 (o)10.6 (n)10.5 (g)-11.2 ( FL)10.5 (,)-6.6 ( R)2.6 (on)10.6 ( E)1.9 (,)-6.6 ( )11.3 (G)-6.6 (i)13.4 (er)-5.9 (l)2.6 (ow)13.5 (s)-2 (k)-12.9 (i)2.6 ( T,)-6.6 ( S)12.9 (c)-2 (hnei)2.6 (der)-5.9 ( A)12.8 (B)2 (.)-6.7 ( B)2 (eni)2.6 (g)-11.2 (n)10.5 ( )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d t)-6.6 (u)10.5 (m)-6 (or)-6 (s)8.9 (:)-6.6 ( )]TJ 0 -1.141 Td [(g)-11.2 (ene)10.5 (r)-5.9 (al)2.6 ( r)-5.9 (i)2.6 (s)8.8 (k)-1.9 ( )11.2 (f)-17.5 (ac)8.9 (t)-6.6 (or)4.9 (s)-2 ( and)10.5 ( t)4.3 (hei)2.6 (r)-5.9 ( e)10.6 (f)-6.6 (f)-6.6 (ec)-2 (t)4.3 (s)-2 ( on)10.6 ( r)-5.9 (adi)2.6 (at)-6.6 (i)2.6 (on)10.5 ( r)5 (i)2.6 (s)-2 (k)-12.9 ( )11.3 (es)-2 (t)-6.6 (i)2.6 (m)-5.9 (a)10.5 (t)-6.6 (i)2.6 (on.)4.3 ( A)1.9 (m)4.9 ( J)-2 ( )]TJ 0 -1.152 Td [(E)2 (pi)2.6 (dem)-5.9 (i)2.6 (ol)2.6 ( 1996;)-6.5 (144:)-6.6 (728)]TJ 0 Tc 0 Tw 10.75 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(733.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.7 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -11.076 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8857821)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 341.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 339.72 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 318.12 Tm [(37.)-6.6 ( R)2.6 (on E)12.8 (,)-6.6 ( D)2.6 (oody)8.9 ( M)4.9 (M)15.8 (,)-6.7 ( B)2 (ec)-1.9 (k)-12.9 (e)10.5 (r)-5.9 ( D)2.7 (V)12.8 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( C)2.6 (anc)-2 (er)4.9 ( )11.3 (m)-6 (or)4.9 (t)-6.6 (al)2.6 (i)2.6 (t)-6.6 (y)8.9 ( )11.3 (f)-17.5 (ol)2.6 (l)2.6 (ow)2.6 (i)2.6 (ng)-11.2 ( )]TJ -0.004 Tw 0 -1.141 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( f)-6.6 (or)5 ( )-10.7 (adul)2.6 (t)4.3 ( )-10.6 (hy)8.9 (per)-6 (t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (di)2.6 (s)-2 (m)-5.9 (.)-6.6 ( )-10.6 (C)2.6 (oope)10.5 (r)-5.9 (at)-6.7 (i)2.7 (v)8.8 (e T)-10.5 (hy)8.9 (r)-5.9 (ot)-6.6 (ox)8.9 (i)2.6 (c)-2 (os)-2 (i)2.6 (s)-2 ( T)-10.6 (her)-6 (apy)8.8 ( )]TJ -0.005 Tc 0.005 Tw 0 -1.152 Td [(F)-2.7 (o)-3.3 (llo)-14.2 (w)]TJ 0 Tc 0 Tw 2.87 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up S)2 (t)-6.7 (udy)8.8 ( G)-6.6 (r)-5.9 (oup)10.5 (.)4.2 ( )11.3 (J)-2 (A)2 (M)15.8 (A)1.9 ( 1998;)-6.6 (280:)-6.6 (347)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 16.902 0 Td [(355)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -20.109 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9686552)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 280.2 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 278.16 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 256.56 Tm [(38.)-6.6 ( )11.3 (Tr)-6 (on)10.5 (k)-12.9 (o M)15.7 (D)2.7 (,)-6.7 ( )0.5 (H)2.6 (ow)13.5 (e G)4.3 (R)2.6 (,)-6.6 ( B)2 (o)10.5 (g)-11.2 (danov)8.8 (a )11.3 (T)-10.6 (I)4.3 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( )11.3 (A)1.9 ( c)-2 (ohor)4.9 (t)-6.6 ( s)8.8 (t)-6.6 (udy)8.9 ( o)10.5 (f)-6.6 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (anc)-2 (er)-6 ( and)10.5 ( ot)4.2 (her)5 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d )11.3 (di)2.7 (s)-2 (eas)-2 (es)-2 ( a)10.6 (f)-6.7 (t)-6.6 (er)4.9 ( t)-6.6 (he)10.6 ( c)-2 (ho)10.5 (r)-5.9 (n)10.5 (oby)8.9 (l)2.6 ( ac)-2 (c)-2 (i)2.6 (dent)-6.6 (:)-6.6 ( t)4.3 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.141 Td [(c)-2 (anc)-2 (er)-6 ( i)2.6 (n)10.5 ( U)13.5 (k)-12.9 (r)-5.9 (ai)2.7 (ne)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 8.043 0 Td [(de)10.5 (t)-6.6 (ec)-2 (t)4.3 (ed dur)-6 (i)2.7 (n)10.5 (g)-11.2 ( )11.2 (f)-17.5 (i)13.5 (r)-5.9 (s)8.8 (t)-6.6 ( s)-2 (c)8.9 (r)-5.9 (eeni)2.6 (n)10.5 (g)-11.2 (.)4.3 ( J)-2 ( N)2.6 (a)10.5 (t)-6.6 (l)2.6 ( C)2.6 (anc)-2 (er)4.9 ( I)-6.6 (ns)8.9 (t)4.3 ( )]TJ 0.002 Tw -8.043 -1.152 Td [(2006;)-6.6 (98:)-6.6 (897)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(903.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (16818853)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 205.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 203.88 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 23.52 182.28 Tm [(39.)-6.6 ( )-10.6 (J)-2 (ac)-2 (ob)10.5 ( )-10.6 (P)2 (,)4.2 ( G)-6.6 (oul)2.6 (k)-12.9 (o)10.6 ( G)-6.6 (,)4.3 ( H)2.7 (ei)2.6 (denr)-6 (ei)2.6 (c)-2 (h )11.1 (W)-36.3 (F)11.2 (,)4.2 ( )-10.5 (et)4.3 ( )-10.6 (al)2.6 (.)4.3 ( Thy)8.9 (r)-6 (oi)2.6 (d )-10.6 (c)-2 (anc)-1.9 (er)-6 ( r)-5.9 (i)2.6 (s)8.8 (k)-12.8 ( t)]TJ 0.002 Tw 29.685 0 Td (o )Tj 0.007 Tw -29.685 -1.141 Td [(c)-2 (hi)2.6 (l)2.6 (dr)-5.9 (en c)-2 (al)2.6 (c)-2 (ul)2.6 (at)-6.5 (ed.)4.3 ( N)2.6 (at)-6.6 (u)10.5 (r)-6 (e 1998)10.5 (;)-6.6 (392:)-6.6 (31)]TJ 0 Tc 0 Tw 17.62 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(32.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -17.957 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9510245)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 156.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 154.92 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 133.32 Tm [(40.)-6.6 ( C)2.6 (ar)-6 (di)2.7 (s)8.8 ( E)2 (,)4.2 ( K)2 (es)-2 (m)-6 (i)2.6 (ni)2.6 (en)10.6 (e A)2 (,)-6.7 ( )11.3 (I)-6.6 (v)8.9 (anov)8.8 ( V)2 (,)-6.6 ( et)4.3 ( al)2.6 (.)4.3 ( R)2.6 (i)2.6 (s)-2 (k)-2 ( o)10.5 (f)-6.6 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-5.9 ( a)10.5 (f)-6.6 (t)-6.6 (e)10.5 (r)-6 ( )]TJ 0 -1.141 Td [(ex)8.8 (pos)-2 (ur)-6 (e t)-6.6 (o 1)10.5 (31I)4.3 ( i)2.6 (n c)-2 (hi)2.6 (l)2.6 (dhood.)-6.6 ( J)8.9 ( N)2.6 (at)-6.6 (l)2.6 ( C)2.6 (anc)-2 (e)10.6 (r)-6 ( )11.3 (I)-6.6 (ns)8.9 (t)-6.6 ( )11.3 (2005;)-6.7 (97:)-6.6 (724)]TJ 0 Tc 0 Tw 27.315 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(732.)4.2 ( )]TJ 0.007 Tw -27.652 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (159000)]TJ (42)Tj EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 108 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 105.96 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 84.36 Tm [(41.)-6.6 ( )11.3 (T)-10.6 (u)10.5 (t)-6.6 (t)-6.6 (l)2.6 (e R)2.6 (M)15.8 (,)-6.6 ( V)1.9 (ai)2.6 (s)-2 (m)-6 (an)10.5 ( )11.3 (F,)-6.7 ( )11.3 (Tr)-5.9 (on)10.6 (k)-12.9 (o M)15.8 (D)2.6 (.)-6.6 ( C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.7 ( pr)-5.9 (es)-2 (ent)-6.6 (at)-6.6 (i)2.6 (on a)10.5 (nd c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( )]TJ 0 -1.141 Td [(out)-6.6 (c)-2 (om)-6 (e)10.5 (s)-2 ( i)2.6 (n C)2.6 (he)10.6 (r)-6 (noby)8.8 (l)]TJ 0 Tc 0 Tw 10.185 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(r)-6 (el)2.6 (at)-6.6 (ed paedi)2.6 (at)-6.6 (r)-5.9 (i)2.6 (c)8.8 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )11.3 (c)-2 (anc)-2 (er)-6 (s)8.9 (:)-6.6 ( w)13.5 (hat)-6.6 ( do)10.5 ( w)13.5 (e )]TJ -10.522 -1.152 Td [(k)-12.9 (now)13.5 ( now)13.5 (? )22.2 (W)-36.3 (ha)10.5 (t)-6.6 ( )11.3 (c)-2 (an w)13.5 (e ex)8.9 (pec)-2 (t)-6.6 ( i)2.6 (n )11.2 (t)-6.6 (he )11.3 (f)-6.6 (ut)-6.6 (u)10.6 (r)-6 (e? C)2.6 (l)2.6 (i)2.6 (n O)-6.6 (nc)-2 (ol)13.5 ( \()-6 (R)2.6 ( C)2.6 (ol)2.6 (l)2.6 ( R)2.6 (adi)2.6 (ol)2.6 (\))-6 ( )]TJ 0.002 Tw 34.554 41.207 Td [(2011;)-6.6 (23:)-6.6 (268)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(275.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.7 (/)4.3 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21324656)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 499.2 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 477.6 Tm [(42.)-6.6 ( S)1.9 (c)-1.9 (hnei)2.6 (der)4.9 ( A)2 (B)2 (.)4.2 ( R)2.6 (adi)2.7 (at)-6.6 (i)2.6 (on)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 12.859 0 Td [(i)2.6 (nduc)-2 (ed )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d t)-6.6 (u)10.5 (m)4.9 (or)-6 (s)-2 (.)4.3 ( E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab )]TJ -12.859 -1.141 Td [(C)2.6 (l)2.6 (i)2.6 (n N)2.6 (or)-5.9 (t)-6.6 (h A)2 (m)4.9 ( 1990)10.5 (;)-6.6 (19:)-6.6 (4)10.5 (95)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 12.359 0 Td [(508.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -12.359 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (2261904)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 452.28 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 450.24 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 428.64 Tm [(43.)-6.6 ( N)2.6 (i)13.5 (k)-12.9 (i)13.5 (f)-17.5 (or)-6 (ov)8.8 ( Y)2 (E)2 (,)4.2 ( N)2.6 (i)2.6 (k)-12.8 (i)13.4 (f)-6.6 (or)-6 (o)10.6 (v)8.8 (a )-10.5 (M)15.8 (,)-6.6 ( Fag)-11.2 (i)2.6 (n)10.6 ( J)-2 (A)2 (.)4.3 ( P)1.9 (r)-5.9 (ev)8.9 (al)2.7 (enc)-2 (e o)10.5 (f)-6.6 ( m)-5.9 (i)2.6 (ni)2.6 (s)-2 (at)-6.6 (el)2.7 (l)2.6 (i)2.6 (t)-6.6 (e and)10.5 ( )]TJ -0.005 Tc 0.01 Tw 0 -1.141 Td [(m)-9 (ic)-5 (r)-8.9 (o)-3.4 (s)-5 (a)7.5 (t)-9.6 (e)-3.3 (llit)-9.6 (e)-3.4 ( in)-3.4 (s)-5 (t)-9.6 (a)-3.3 (b)-3.4 (ilit)-9.6 (y)5.9 ( in)-3.4 ( r)-9 (a)-3.3 (d)-3.4 (ia)-3.3 (t)-9.6 (io)-3.4 (n)]TJ 0 Tc 0 Tw 15.348 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(i)2.6 (nduc)-2 (ed)10.5 ( pos)-1.9 (t)]TJ 0 Tc 0 Tw 5.641 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(C)2.6 (her)-6 (noby)8.9 (l)2.6 ( pedi)2.7 (at)-6.6 (r)-6 (i)2.7 (c)-2 ( )]TJ -21.652 -1.152 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (as)-1.9 (.)4.2 ( O)-6.6 (n)10.5 (c)8.9 (og)-11.1 (ene)10.5 ( 1998;)-6.6 (17)10.5 (:)-6.6 (1983)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 20.228 0 Td [(19)10.5 (88.)-6.6 ( A)1.9 (v)8.9 (ai)]TJ 4.696 0 Td [(l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -24.924 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9788442)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 390.72 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 388.68 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 367.08 Tm [(44.)-6.6 ( K)1.9 (apl)2.6 (an M)4.9 (M)15.8 (.)-6.6 ( C)2.6 (l)2.6 (i)2.6 (ni)2.7 (c)-2.1 (al)2.6 ( ev)8.8 (al)2.6 (uat)-6.6 (i)2.6 (on and m)-6 (ana)10.5 (g)-11.2 (e)10.5 (m)-5.9 (ent)4.3 ( o)10.5 (f)-6.6 ( s)-2 (ol)2.6 (i)2.6 (t)-6.6 (ar)-6 (y)8.9 ( t)4.3 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.152 Td [(nodul)2.6 (es)-2 (.)-6.6 ( I)-6.7 (n)10.6 (:)4.2 ( B)2 (r)-6 (av)8.9 (er)-5.9 (m)-6 (an)10.5 ( )11.2 (LE)2 (,)-6.7 ( U)2.7 (t)-6.6 (i)13.4 (g)-11.2 (er)4.9 ( R)2.6 (D)2.6 (,)4.3 ( eds)-2 (.)4.2 ( )22.2 (W)-36.3 (e)10.5 (r)15.8 (ner)-5.9 ( and)10.5 ( I)-6.6 (n)10.5 (g)-11.2 (ba)10.6 (r)-6 (')-6.7 (s)8.9 ( )11.3 (T)-10.6 (he )]TJ 0.002 Tw 0 -1.141 Td [(T)-10.6 (hy)8.9 (r)-6 (oi)]TJ 0.007 Tw 2.772 0 Td [(d:)-6.6 ( A)12.9 ( Fundam)-6 (en)10.5 (t)-6.6 (al)2.7 ( )11.2 (and C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( T)-10.5 (ex)8.9 (t)-6.6 (,)-6.6 ( 9)10.5 (t)-6.6 (h )11.3 (ed.)4.3 ( P)1.9 (hi)2.6 (l)2.6 (adel)2.6 (phi)2.6 (a:)-6.6 ( Li)2.6 (ppi)2.6 (nc)-2 (ot)-6.6 (t)-6.6 ( )]TJ -2.772 -1.141 Td [(W)-25.4 (i)13.5 (l)2.6 (l)2.6 (i)2.6 (am)-6 (s)-2 ( &)12.8 ( )22.2 (W)-36.3 (i)2.6 (l)13.5 (k)-12.9 (i)2.7 (ns)8.9 (;)4.2 ( 2005)10.5 (:)-6.6 (996)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 13.13 0 Td [(1010)10.5 (.)]TJ 0 Tc 0 Tw 2.478 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -15.609 -2.141 Td [(45.)-6.6 ( Lay)19.7 (f)-17.4 (i)2.6 (el)2.6 (d LJ)-2 (,)4.3 ( C)2.6 (i)2.6 (bas)-2 ( E)12.9 (S)1.9 (,)-6.6 ( )11.3 (G)-6.6 (har)-6 (i)2.6 (b H)13.5 (,)-6.7 ( M)15.8 (andel)2.6 ( S)2 (J)-2 (.)-6.6 ( )11.3 (T)-10.6 (hy)8.9 (r)-5.9 (oi)2.6 (d as)-2 (pi)2.6 (r)-6 (a)10.6 (t)-6.7 (i)2.7 (on )]TJ 0 -1.152 Td [(c)-2 (y)8.9 (t)-6.6 (ol)2.6 (og)-11.2 (y)8.8 (:)-6.6 ( c)-2 (ur)4.9 (r)-6 (ent)4.3 ( s)8.9 (t)-6.6 (at)-6.6 (us)8.8 (.)-6.6 ( )11.3 (C)2.6 (A)2 ( C)2.6 (anc)-2 (er)-5.9 ( J)8.8 ( C)2.6 (l)2.7 (i)2.6 (n 2009;)-6.6 (5)10.5 (9:)-6.6 (99)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 24.054 0 Td [(110)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -24.054 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19278960)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 280.2 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 278.16 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 256.56 Tm [(46.)-6.6 ( C)2.6 (z)8.9 (er)-5.9 (w)13.5 (onk)-12.9 (a L)10.6 (,)-6.6 ( F)11.2 (r)-5.9 (eem)4.9 (an J)-2 (,)4.2 ( )0.5 (M)15.7 (c)-2 (I)-6.6 (v)8.9 (er)-6 ( B)2 (,)-6.7 ( )0.5 (e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( S)1.9 (u)10.6 (m)-6 (m)-5.9 (a)10.5 (r)-6 (y)8.9 ( o)10.5 (f)-6.6 ( pr)-5.9 (oc)-2 (eedi)2.6 (n)10.5 (g)-11.2 (s)8.9 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.152 Td [(t)-6.6 (he s)-2 (ec)-2 (ond)10.6 ( )22.1 (W)-36.3 (o)10.6 (r)4.9 (l)2.6 (d C)2.7 (on)10.5 (g)-11.2 (r)4.9 (es)-2 (s)-2 ( on )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d C)2.6 (anc)-2 (e)10.5 (r)-5.9 (.)4.2 ( )11.3 (H)2.6 (ead N)2.6 (ec)8.9 (k)-12.9 ( 2014)10.5 (;)-6.6 (36:)-6.6 (917)]TJ 0 Tc 0 Tw 32.076 0 Td (-)Tj -0.002 Tc 0.007 Tw -32.076 -1.141 Td [(920.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.7 (abl)2.6 (e at)-6.6 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.2 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.7 (h.)-6.6 (g)-11.2 (ov)8.9 (/)-6.6 (pu)10.5 (bm)-5.9 (ed/)-6.6 (24677329)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 721.2 231.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 492.6 229.2 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 207.6 Tm [(47.)-6.6 ( S)1.9 (hr)-6 (e)10.6 (s)-2 (t)-6.6 (ha)10.6 ( M)15.8 (,)-6.6 ( C)2.6 (r)-5.9 (ot)-6.6 (he)10.5 (r)4.9 (s)-2 ( B)1.9 (A)2 (,)-6.6 ( B)2 (u)10.5 (r)-6 (c)-2 (h)10.6 ( H)2.6 (B)1.9 (.)-6.6 ( )11.3 (T)-10.6 (he)10.5 ( i)2.6 (m)-6 (p)10.6 (ac)-2 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d nodul)2.6 (e s)-2 (i)2.6 (z)8.9 (e )]TJ 0 -1.152 Td [(on t)-6.6 (he)10.6 ( r)-6 (i)2.6 (s)8.9 (k)-2 ( o)10.5 (f)-6.6 ( m)-6 (al)2.6 (i)13.5 (g)-11.2 (nanc)-2 (y)8.9 ( and ac)-2 (c)-2 (u)10.5 (r)-5.9 (ac)-2 (y)8.9 ( o)10.5 (f)-6.6 ( )11.3 (f)-17.5 (i)2.6 (ne)]TJ 0 Tc 0 Tw 20.217 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(ne)10.5 (edl)2.6 (e as)-2 (pi)2.7 (r)-6 (at)-6.6 (i)2.6 (on:)4.2 ( a 10)]TJ 0 Tc 0 Tw 10.076 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(y)8.9 (ear)-6 ( )]TJ -0.004 Tw -30.967 -1.141 Td [(s)-2 (t)-6.6 (udy)8.9 ( f)-17.4 (r)]TJ 0.007 Tw 3.283 0 Td [(o)10.5 (m)4.9 ( a s)-2 (i)2.6 (n)10.5 (g)-11.2 (l)2.6 (e i)2.6 (ns)-2 (t)-6.6 (i)13.5 (t)4.3 (ut)-6.6 (i)2.6 (on.)-6.6 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.7 (d 2012)10.5 (;)-6.6 (22:)-6.6 (1)10.5 (251)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 20.152 0 Td [(1256.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -23.435 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22962940)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 169.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 167.64 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 145.92 Tm [(48.)-6.6 ( K)1.9 (oi)13.5 (k)-12.9 (e E)12.8 (,)-6.6 ( N)2.6 (o)10.5 (g)-11.2 (uc)-2 (hi)2.6 ( S)12.8 (,)-6.6 ( )11.3 (Y)2 (am)-6 (as)-2 (hi)2.6 (t)-6.6 (a H)13.5 (,)-6.6 ( e)10.5 (t)-6.6 ( al)13.5 (.)-6.6 ( U)2.6 (l)2.6 (t)-6.6 (r)-5.9 (a)10.5 (s)-2 (onogr)-5.9 (aphi)2.6 (c)-2 ( )]TJ 0 -1.141 Td [(c)-2 (har)-6 (ac)-2 (t)-6.6 (e)10.5 (r)-5.9 (i)2.6 (s)-2 (t)-6.6 (i)2.6 (c)-2 (s)8.8 ( o)10.6 (f)-6.6 ( t)-6.7 (hy)8.9 (r)-6 (o)]TJ [(i)2.6 (d )11.3 (nodul)2.6 (es)-2 (:)-6.6 ( pr)-5.9 (edi)2.6 (c)8.9 (t)-6.7 (i)2.7 (on o)10.5 (f)-6.6 ( )11.2 (m)5 (al)2.6 (i)2.6 (g)-11.2 (nanc)-2 (y)8.8 (.)-6.6 ( A)2 (r)-6 (c)-2 (h)10.6 ( S)1.9 (ur)4.9 (g )]TJ 0.002 Tw 0 -1.141 Td [(2001;)-6.6 (136:)-6.6 (334)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(337.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (11231857)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 108 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 105.96 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 84.36 Tm [(49.)-6.6 ( B)1.9 (al)2.6 (oc)-2 (h Z)32.9 (W)-36.2 (,)4.2 ( )11.3 (C)2.6 (i)2.6 (bas)-2 ( E)12.8 (S)2 (,)-6.6 ( C)2.6 (l)2.6 (ar)4.9 (k)-2 ( D)2.6 (P)2 (,)-6.7 ( e)10.6 (t)-6.6 ( al)2.6 (.)4.3 ( )11.2 (T)-10.5 (he)10.6 ( N)2.7 (at)-6.6 (i)2.6 (onal)2.6 ( C)2.6 (anc)-2 (er)-5.9 ( )11.3 (I)-6.7 (ns)8.9 (t)-6.6 (i)2.6 (t)-6.6 (ut)-6.6 (e)]TJ 0 Tc 0 Tw 31.685 0 Td ( )Tj -0.002 Tc 0.007 Tw -31.685 -1.141 Td [(T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d )11.3 (f)-17.5 (i)2.6 (ne)10.5 ( needl)2.6 (e as)-2 (pi)2.6 (r)4.9 (at)-6.7 (i)2.6 (on )0.5 (s)-2.1 (t)-6.5 (a)10.5 (t)-6.6 (e)10.5 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.6 ( s)-2 (c)-2 (i)2.6 (enc)-2 (e)10.5 ( c)-2 (on)10.6 (f)-17.5 (e)10.5 (r)-5.9 (enc)-2 (e:)4.3 ( a)10.5 ( )]TJ 0 -1.152 Td [(s)-2 (um)-6 (m)-6 (a)10.6 (t)-6.6 (i)2.6 (on.)4.2 ( C)2.6 (y)8.9 (t)-6.6 (oj)-8.3 (our)-6 (nal)13.4 ( )11.3 (2008;)-6.6 (5:)-6.7 (6)10.6 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 0 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (18394201)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 46.44 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 44.4 228.72 0.841 re f EMC endstream endobj 919 0 obj 27181 endobj %% Contents for page 104 %% Original object ID: 209 0 920 0 obj << /Length 921 0 R >> stream Q q BT /Xi102 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 921 0 obj 246 endobj %% Original object ID: 11499 0 922 0 obj [ 2707 0 R 2708 0 R 2709 0 R 2710 0 R 2711 0 R 2712 0 R 2713 0 R 2714 0 R 2715 0 R 2716 0 R 2717 0 R 2718 0 R 2719 0 R 2720 0 R 2721 0 R ] endobj %% Contents for page 105 %% Original object ID: 210 0 923 0 obj << /Length 924 0 R >> stream q endstream endobj 924 0 obj 2 endobj %% Contents for page 105 %% Original object ID: 11500 0 925 0 obj << /Length 926 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (42)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(50.)-6.6 ( Y)1.9 (an)10.5 (g J)-2 (,)4.2 ( S)2 (c)-2 (hnadi)2.6 (g V)1.9 (,)4.3 ( )11.3 (Logr)-5.9 (ono R)2.6 (,)4.3 ( )22.1 (W)-36.2 (a)]TJ -0.004 Tw 17.685 0 Td [(s)8.9 (s)-2 (er)4.9 (m)-5.9 (an P)2 (G)-6.6 (.)4.3 ( )-10.6 (Fi)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 8.359 0 Td [(needl)2.6 (e )]TJ 0.007 Tw -26.043 -1.152 Td [(as)-2 (pi)2.6 (r)-5.9 (at)-6.6 (i)2.6 (on o)10.6 (f)-6.7 ( )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d nod)10.5 (ul)2.6 (es)-2 (:)-6.6 ( a )11.2 (s)-2 (t)-6.6 (udy)8.9 ( o)10.5 (f)-6.6 ( 4703)10.5 ( pat)-6.6 (i)13.5 (ent)-6.6 (s)-2 ( w)13.4 (i)2.6 (t)-6.6 (h hi)2.6 (s)-2 (t)-6.7 (ol)2.6 (o)10.5 (g)-11.2 (i)2.6 (c)-2 ( and)10.6 ( )]TJ 0 -1.141 Td [(c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.7 ( c)-2 (or)-6 (r)-5.9 (el)2.7 (at)-6.6 (i)2.6 (ons)-2 (.)4.3 ( C)2.6 (anc)-2 (er)-5.9 ( 2007)10.6 (;)-6.6 (111:)-6.6 (306)]TJ 0 Tc 0 Tw 18.565 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(315.)4.2 ( A)12.8 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -18.902 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed)]TJ [(/)-6.6 (17680588)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 473.88 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 452.28 Tm [(51.)-6.6 ( R)2.6 (i)2.6 (nal)2.6 (di)2.6 ( S)1.9 (,)-6.6 ( P)2 (l)2.6 (um)4.9 (m)-6 (e)10.5 (r)-5.9 ( )11.3 (M)15.7 (,)-6.6 ( B)2 (i)2.6 (es)-2 (s)-2 (y)8.9 ( C)2.6 (,)-6.6 ( et)-6.6 ( al)2.6 (.)4.3 ( )11.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 22.435 0 Td [(s)-2 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (a)10.5 (t)-6.6 (i)2.6 (ng hor)5 (m)-6 (one)10.5 (,)-6.6 ( )]TJ -22.435 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (og)-11.2 (l)2.6 (obul)2.6 (i)2.6 (n,)-6.6 ( and)10.5 ( )0.5 (t)-6.7 (hy)8.9 (r)-6 (oi)13.4 (d hor)4.9 (m)-5.9 (ones)-2 ( and)10.6 ( r)-5.9 (i)2.6 (s)8.9 (k)-2 ( o)10.5 (f)-6.6 ( d)10.5 (i)2.6 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.6 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (:)-6.6 ( )11.3 (t)-6.7 (he E)2 (P)12.8 (I)-6.6 (C)2.6 ( s)8.9 (t)-6.6 (u)10.5 (dy)8.8 (.)-6.6 ( J)-2 ( N)2.6 (at)-6.6 (l)2.6 ( C)2.6 (anc)-2 (e)10.5 (r)-5.9 ( )11.2 (I)-6.6 (ns)8.8 (t)-6.6 ( 20)10.5 (14;)-6.6 (106:)-6.6 (d)10.5 (j)-8.3 (u097.)4.3 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e)-11.2 ( )]TJ -0.006 Tc 0.006 Tw 0 -1.141 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (24824312)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 267.48 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 38.88 412.32 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 390.72 Tm [(52.)-6.6 ( M)15.8 (c)-2 (Leod D)2.6 (S)1.9 (,)-6.5 ( )33 (W)-36.3 (a)10.5 (t)4.3 (t)-6.6 (er)-5.9 (s)8.8 ( K)2 (F,)-6.6 ( C)2.6 (a)10.5 (r)-5.9 (pent)-6.6 (e)10.5 (r)-5.9 ( A)1.9 (D)13.5 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( )11.3 (T)-10.5 (hy)8.9 (r)-6 (ot)-6.6 (r)-6 (opi)2.6 (n and)10.5 ( )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (anc)-2 (er)-6 ( di)2.7 (a)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)8.9 (:)-6.6 ( a)10.6 ( s)-2 (y)8.8 (s)-2 (t)4.3 (em)-6 (at)-6.6 (i)2.6 (c)8.9 ( r)-5.9 (ev)8.9 (i)2.6 (ew)13.4 ( and dos)-2 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 21.435 0 Td [(r)-6 (es)-2 (pons)-2 (e m)-6 (e)10.5 (t)-6.6 (a)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 6.935 0 Td [(anal)2.6 (y)8.9 (s)-2.1 (i)2.7 (s)-2 (.)-6.7 ( )]TJ -0.005 Tc 0.01 Tw -28.37 -1.141 Td [(J)-5 ( Clin)-3.4 ( E)-1 (n)-3.4 (d)]TJ -0.002 Tc 0.007 Tw 4.543 0 Td [(oc)-2 (r)-6 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.5 (ab 2012;)-6.6 (97:)-6.6 (2682)]TJ 0 Tc 0 Tw 12.359 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(2692.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -17.239 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22622023)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 350.76 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 329.16 Tm [(53.)-6.6 ( J)-2 (i)2.6 (n )11.2 (J)-2 (,)4.3 ( M)15.8 (ac)-2 (hek)-12.8 (ano R)13.5 (,)-6.6 ( )11.3 (M)15.7 (c)-2 (H)2.6 (enr)-16.8 (y)8.9 ( C)2.6 (R)2.6 (.)-6.6 ( T)-10.6 (he)10.5 ( u)10.5 (t)-6.6 (i)2.6 (l)2.6 (i)2.7 (t)-6.7 (y)8.9 ( o)10.5 (f)-17.4 ( p)10.5 (r)-6 (eoper)-5.9 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e s)-2 (er)-6 (um)4.9 ( )]TJ 0.002 Tw 0 -1.152 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 3.326 0 Td [(s)-2 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (at)-6.6 (i)2.6 (n)10.5 (g hor)5 (m)4.9 (one l)2.6 (ev)8.9 (el)2.6 ( )]TJ [(f)-17.4 (o)10.5 (r)-6 ( p)10.5 (r)-5.9 (edi)2.6 (c)-2 (t)-6.6 (i)2.6 (n)10.5 (g)-11.2 ( )11.3 (m)-6 (al)2.6 (i)2.6 (g)-11.2 (nan)10.5 (t)-6.6 ( nodul)2.6 (ar)4.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)13.5 (d )]TJ -3.326 -1.141 Td [(di)2.6 (s)-2 (eas)-2 (e.)-6.6 ( A)12.8 (m)-5.9 ( J)8.9 ( S)1.9 (ur)4.9 (g 201)10.5 (0;)-6.6 (199:)-6.6 (294)]TJ 0 Tc 0 Tw 15.011 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(297;)4.2 ( di)2.6 (s)-2 (c)-2 (us)-1.9 (s)-2.1 (i)2.7 (o)10.5 (n 298.)4.3 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.7 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -15.348 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (20226898)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 291.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 289.08 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 267.48 Tm [(54.)-6.6 ( H)2.6 (ay)8.8 (m)-5.9 (ar)4.9 (t)-6.6 ( M)15.8 (R)2.6 (,)-6.6 ( R)2.6 (eppl)2.6 (i)2.6 (ng)-11.3 (e)10.6 (r)-6 ( D)2.6 (J)8.9 (,)-6.6 ( Lev)8.9 (er)-5.9 (s)-2.1 (on )11.2 (G)-6.6 (E)12.8 (,)]TJ 0 Tc 0 Tw 20.772 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( H)2.7 (i)2.6 (g)-11.3 (he)10.5 (r)-5.9 ( s)-2 (e)10.5 (r)-6 (u)10.6 (m)-6 ( )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ -21.054 -1.141 Td [(s)-2 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (at)-6.6 (i)2.6 (n)10.5 (g)-11.2 ( ho)10.6 (r)-6 (m)4.9 (one l)2.6 (ev)8.9 (el)2.7 ( i)2.7 (n t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d nodul)2.6 (e pa)10.5 (t)-6.6 (i)2.6 (ent)4.3 (s)-2 ( i)2.6 (s)-2 ( as)-2 (s)-2 (o)10.5 (c)-2 (i)2.6 (at)-6.6 (ed )0.5 (w)13.4 (i)2.6 (t)-6.6 (h )]TJ 0 -1.152 Td [(g)-11.2 (r)4.9 (eat)-6.6 (e)10.5 (r)-5.9 ( )11.2 (r)-5.9 (i)2.6 (s)-2 (k)-2 (s)-2 ( o)10.5 (f)-6.6 ( di)13.5 (f)-6.6 (f)-6.6 (er)-6 (en)10.5 (t)-6.6 (i)13.5 (at)-6.6 (ed )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2.1 (anc)-2 (er)4.9 ( and )11.2 (adv)8.9 (anc)-2 (ed t)-6.6 (um)-6 (o)10.5 (r)-5.9 ( s)8.9 (t)-6.7 (a)10.6 (g)-11.2 (e.)4.3 ( J)8.8 ( )]TJ 0 -1.141 Td [(C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.7 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2008;)-6.6 (93:)-6.6 (809)]TJ 0 Tc 0 Tw 15.565 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(814.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)-8.2 (e at)4.2 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -15.902 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (18160464)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 216.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 214.92 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 193.32 Tm [(55.)-6.6 ( B)1.9 (onav)8.9 (i)2.6 (t)-6.6 (a J)-2 (A)2 (,)4.3 ( M)15.7 (ay)8.9 (o J)-2 (,)-6.6 ( B)2 (abb J)8.9 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( P)2 (at)4.3 (t)-6.6 (er)-5.9 (n)10.5 ( r)-6 (e)10.5 (c)-2 (og)-11.2 (ni)2.7 (t)-6.7 (i)2.7 (on)10.5 ( o)10.5 (f)-6.6 ( beni)2.6 (g)-11.2 (n)10.5 ( )]TJ 0 -1.152 Td [(nodul)2.6 (es)-2 ( at)-6.6 ( ul)13.4 (t)-6.6 (r)-5.9 (as)-2 (ound)10.5 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (he )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d:)-6.6 ( w)13.5 (hi)2.6 (c)-2 (h nodul)2.6 (es)-2 ( c)-2 (an be)10.5 ( l)2.6 (e)10.5 (f)-6.6 (t)-6.6 ( al)2.6 (one? A)1.9 (J)-2 (R)13.5 ( )]TJ 0 -1.141 Td [(A)2 (m)-6 ( J)8.9 ( R)2.6 (oent)4.3 (g)-11.2 (enol)2.7 ( 2009)10.5 (;)-6.6 (1)10.6 (93:)-6.6 (207)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 14.359 0 Td [(213)10.5 (.)]TJ 0 Tc 0 Tw 1.935 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -16.576 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19542415)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 155.28 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 153.24 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 131.64 Tm [(56.)-6.6 ( F)11.2 (r)-6 (i)2.6 (edr)-5.9 (i)2.6 (c)-2 (h)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 5.88 0 Td [(R)2.6 (us)-2 (t)4.2 ( M)15.8 (,)-6.6 ( M)15.8 (e)-11.2 (y)8.8 (er)-6 ( G)-6.6 (,)4.3 ( D)2.6 (aut)-6.6 (h)10.5 ( N)2.6 (,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( )11.3 (I)-6.6 (n)10.5 (t)4.3 (er)-5.9 (obs)-2 (er)-5.9 (v)8.8 (er)-5.9 ( a)10.5 (gr)-5.9 (ee)10.5 (m)-5.9 (ent)4.3 ( o)10.5 (f)-6.6 ( )]TJ -5.88 -1.141 Td [(T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d I)4.3 (m)-6 (a)10.6 (g)-11.3 (i)2.6 (n)10.6 (g)-11.2 ( R)2.6 (epo)10.5 (r)-6 (t)-6.6 (i)13.5 (ng and D)2.6 (at)-6.6 (a)10.5 ( S)2 (y)8.9 (s)-2 (t)-6.6 (em)4.9 ( \()4.9 (TI)4.3 (R)2.6 (A)2 (D)2.6 (S)1.9 (\))-5.9 ( and s)8.9 (t)-6.6 (r)-6 (ai)2.6 (n )]TJ 0 -1.152 Td [(el)2.6 (as)-2 (t)-6.6 (ogr)-5.9 (aphy)8.9 ( )11.3 (f)-17.5 (o)10.5 (r)-6 ( )11.3 (t)-6.6 (he as)8.8 (s)8.9 (es)-2 (s)-2 (m)-6 (en)10.6 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d nodul)2.6 (es)-2 (.)-6.6 ( P)1.9 (LoS)12.8 ( O)-6.6 (ne)10.5 ( )]TJ 0 -1.141 Td [(2013;)-6.6 (8:)-6.7 (e77927)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)-8.2 (e at)4.2 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 0 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24205031)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 81.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 79.08 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 57.48 Tm [(57.)-6.6 ( A)1.9 (l)2.7 (ex)8.9 (ander)-6 ( E)2 (K)2 (,)4.2 ( C)2.6 (ooper)-5.9 ( D)2.6 (.)4.2 ( )11.3 (T)-10.6 (he )0.5 (i)13.4 (m)-5.9 (por)4.9 (t)-6.6 (anc)-2 (e,)4.3 ( an)10.5 (d i)2.6 (m)-5.9 (por)4.9 (t)-6.6 (ant)4.3 ( l)2.6 (i)2.6 (m)]TJ 0.005 Tc 0 Tw 28.261 0 Td [(i)9.6 (ta)17.5 (ti)9.6 (o)6.7 (n)6.7 (s)5 (, o)17.5 (f)11.2 ( )]TJ -0.002 Tc 0.007 Tw -28.261 -1.152 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2 (ound i)13.4 (m)-5.9 (a)10.5 (g)-11.2 (i)2.6 (ng )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( e)10.5 (v)8.9 (al)2.6 (uat)-6.6 (i)2.6 (ng)-11.2 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d nodul)2.7 (es)8.9 (.)-6.6 ( J)-2 (A)1.9 (M)15.8 (A)2 ( I)-6.6 (nt)-6.6 (e)10.5 (r)-5.9 (n M)15.8 (ed )]TJ 0.002 Tw 34.554 42.5 Td [(2013;)-6.6 (173:)-6.6 (1796)]TJ 0 Tc 0 Tw 6.652 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1797.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.989 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (23979653)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 499.2 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.005 Tc 0.01 Tw 11.04 -0 0 11.04 405 477.6 Tm [(5)-3.3 (8)-3.4 (.)-9.6 ( Ho)-3.4 (r)-9 (v)5.9 (a)-3.3 (t)-9.6 (h)7.5 ( E)-1.1 (,)1.2 ( M)12.8 (a)-3.3 (j)-11.3 (lis)-5 ( S)-1.1 (,)-9.6 ( )11.3 (Ro)-3.4 (s)-5 (s)-5 (i R,)-9.6 ( e)7.5 (t)-9.6 ( )]TJ -0.002 Tc 0.007 Tw [(al)2.6 (.)4.3 ( A)1.9 (n ul)13.5 (t)-6.6 (r)-5.9 (as)-2 (o)10.5 (nogr)-6 (am)4.9 ( r)-6 (epo)10.6 (r)-6 (t)-6.6 (i)2.6 (n)10.5 (g)-11.2 ( )11.3 (s)-2 (y)8.9 (s)-2 (t)-6.7 (em)4.9 ( )]TJ 0 -1.141 Td [(f)-6.6 (or)5 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d nodul)2.7 (es)-2 ( s)8.9 (t)-6.6 (r)4.9 (at)-6.6 (i)13.5 (f)-6.6 (y)8.9 (i)2.6 (ng)-11.2 ( c)-2 (anc)-2 (er)4.9 ( r)-6 (i)2.6 (s)8.9 (k)-2 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( m)-5.9 (ana)10.5 (g)-11.2 (e)10.5 (m)-6 (ent)4.3 (.)-6.6 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n )]TJ 0 -1.152 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2009;)-6.6 (9)10.6 (4:)-6.6 (1748)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.467 0 Td [(1751)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.467 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)]TJ 14.902 0 Td [(ed/)-6.6 (19276237)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 439.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 437.64 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 416.04 Tm [(59.)-6.6 ( K)1.9 (a)10.6 (m)-6 (r)-5.9 (an)10.5 ( S)2 (C)2.6 (,)-6.6 ( M)15.8 (ar)-5.9 (q)-11.2 (u)10.5 (s)8.9 (ee E)2 (,)-6.6 ( K)2 (i)13.4 (m)-5.9 ( M)15.8 (I)-6.7 (,)-6.6 ( e)10.6 (t)-6.6 ( al)13.5 (.)-6.6 ( )11.2 (T)-10.5 (hy)8.9 (r)4.9 (oi)2.6 (d nodul)2.7 (e s)-2 (i)2.6 (z)8.9 (e and )]TJ 0 -1.152 Td [(pr)-6 (edi)2.6 (c)-2 (t)-6.6 (i)2.6 (on o)10.6 (f)-6.7 ( c)-2 (anc)-2 (e)10.6 (r)-6 (.)4.3 ( J)8.8 ( C)2.6 (l)2.6 (i)2.7 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2013;)-6.6 (98:)-6.6 (564)]TJ 0 Tc 0 Tw 25.598 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(570.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e )]TJ -0.006 Tc 0.006 Tw -25.935 -1.141 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (23275525)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 648.96 390.72 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 420.36 388.68 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 367.08 Tm [(60.)-6.6 ( S)12.8 (m)-5.9 (i)2.6 (t)-6.6 (h)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 4.554 0 Td [(B)2 (i)2.6 (ndm)-6 (an)10.5 ( R)2.6 (,)4.3 ( L)10.5 (ebda P)2 (,)4.2 ( Fel)2.6 (ds)-2 (t)-6.6 (ei)2.6 (n V)2 (A)2 (,)4.2 ( et)4.2 ( )11.3 (al)2.5 (.)-6.6 ( )0.5 (R)2.6 (i)2.6 (s)-2 (k)-2 ( o)10.5 (f)-6.6 ( )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 ( )]TJ -4.554 -1.152 Td [(bas)-2 (ed on )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d ul)2.6 (t)-6.6 (r)-6 (a)10.6 (s)-2 (o)10.5 (und i)2.6 (m)-6 (a)10.5 (g)-11.2 (i)2.6 (n)10.6 (g)-11.3 ( c)-2 (ha)10.5 (r)-5.9 (ac)-2 (t)-6.6 (e)10.5 (r)-5.9 (i)2.6 (s)-2 (t)-6.6 (i)13.4 (c)-2 (s)-2 (:)-6.6 ( )11.3 (r)-5.9 (es)-2 (ul)2.6 (t)-6.6 (s)8.8 ( o)10.5 (f)-6.6 ( a)10.6 ( )]TJ 0.002 Tw 0 -1.141 Td [(popul)2.6 (at)-6.6 (i)2.6 (on)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 4.935 0 Td [(bas)-2 (ed s)8.9 (t)-6.6 (udy)8.9 (.)-6.7 ( )11.3 (J)-2 (A)2 (M)15.8 (A)1.9 ( I)-6.6 (nt)-6.7 (er)-6 (n M)15.8 (ed 2013;)-6.6 (1)10.5 (73:)-6.6 (1788)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 20.891 0 Td [(1796)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e )]TJ 0 Tc 0 Tw -25.826 -1.141 Td (a)Tj -0.006 Tc 0.006 Tw 0.554 0 Td [(t)-10.6 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 0.837 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (23978950)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 648.96 329.16 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 420.36 327.12 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 305.52 Tm [(61.)-6.6 ( Y)1.9 (oo)10.5 ( )22.2 (W)-36.3 (S)12.8 (,)4.3 ( C)2.6 (hoi)2.6 ( H)2.6 (S)2 (,)4.2 ( C)2.6 (ho S)23.7 (W)-36.2 (,)4.3 ( )11.2 (et)4.2 ( al)2.6 (.)4.2 ( )11.3 (T)-10.6 (he )11.2 (r)-5.9 (ol)2.6 (e o)10.5 (f)-6.6 ( )11.3 (ul)2.6 (t)-6.6 (r)-5.9 (as)-2 (ound )11.3 (f)-6.6 (i)2.6 (ndi)2.6 (ng)-11.3 (s)8.9 ( i)2.6 (n )]TJ 0 -1.152 Td [(t)-6.6 (he )11.3 (m)-6 (ana)10.5 (g)-11.2 (em)-6 (en)10.5 (t)4.3 ( o)10.5 (f)-6.6 ( t)-6.6 (hy)8.9 (r)-6 (o)10.6 (i)2.6 (d nodul)2.6 (es)-2 ( w)13.5 (i)2.6 (t)-6.6 (h at)-6.6 (y)8.8 (pi)2.6 (a or)-6 ( )11.3 (f)-6.6 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( l)2.6 (es)-2 (i)2.6 (ons)-2 ( o)10.5 (f)-6.6 ( )]TJ 0.002 Tw 0 -1.141 Td [(undet)-6.6 (e)]TJ 0.007 Tw [(r)4.9 (m)-6 (i)2.6 (ned s)-2 (i)13.5 (g)-11.3 (ni)13.5 (f)-17.5 (i)2.6 (c)-2 (anc)8.9 (e.)-6.6 ( C)2.6 (l)2.6 (i)2.7 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( )11.3 (\()-6 (O)-6.6 (x)19.7 (f)-17.4 (\))4.9 ( )11.2 (2014;)-6.6 (80:)-6.7 (735)]TJ 0 Tc 0 Tw 27.141 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(742.)4.2 ( )]TJ 0.007 Tw -27.478 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (24117478)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 267.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 265.44 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 243.84 Tm [(62.)-6.6 ( B)1.9 (er)4.9 (t)-6.6 (a)10.5 (g)-11.2 (na)10.5 ( F,)4.2 ( )11.3 (T)-10.5 (r)-6 (e)10.5 (g)-11.2 (l)2.6 (i)2.6 (a )11.3 (G)-6.7 (,)4.3 ( P)2 (i)2.6 (c)-2 (c)-2 (ar)-5.9 (do)10.6 ( A)2 (,)4.3 ( G)-6.7 (i)2.7 (ubbi)2.6 (ni)2.6 ( )11.3 (R)2.6 (.)-6.6 ( D)2.6 (i)2.6 (ag)-11.2 (no)10.5 (s)-2 (t)-6.6 (i)2.6 (c)-2 ( and)10.5 ( c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( )]TJ 0 Tc 0 Tw 0 -1.141 Td (si)Tj -0.002 Tc 0.007 Tw 0.717 0 Td [(g)-11.2 (ni)13.5 (f)-17.5 (i)2.7 (c)-2.1 (anc)-2 (e)10.5 ( o)10.5 (f)-6.6 ( F)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 6.826 0 Td (18)Tj 0 Tc 0 Tw 1.098 0 Td (-)Tj -0.005 Tc 0.005 Tw 0.337 0 Td [(F)-2.7 (DG)]TJ 0 Tc 0 Tw 2.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(P)2 (E)1.9 (T/)-6.6 (C)13.5 (T)-10.6 ( )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d i)2.6 (nc)-2 (i)2.6 (dent)-6.6 (al)2.7 (om)-5.9 (as)-2 (.)4.3 ( J)-2 ( C)2.6 (l)2.6 (i)2.6 (n )]TJ -11.413 -1.152 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2012;)-6.6 (9)10.6 (7:)-6.6 (3866)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.467 0 Td [(3875)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.467 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22904176)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 205.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 203.88 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 182.28 Tm [(63.)-6.6 ( )11.3 (I)-6.6 (t)-6.7 (o)10.6 ( Y)1.9 (,)4.3 ( M)15.8 (i)-8.3 (y)8.9 (auc)-2 (hi)2.7 ( A)2 (,)-6.6 ( I)-6.6 (no)10.6 (ue H)2.6 (,)-6.6 ( e)10.5 (t)-6.6 ( )11.2 (al)2.6 (.)-6.6 ( A)]TJ 16.848 0 Td [(n)10.5 ( obs)-2 (er)-6 (v)8.9 (at)-6.6 (i)13.5 (onal)2.6 ( t)-6.6 (r)-6 (i)2.6 (al)2.6 ( )11.3 (f)-6.6 (or)4.9 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( )]TJ -16.848 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d m)-6 (i)2.6 (c)-2 (r)-5.9 (oc)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( i)13.4 (n J)-2 (apanes)-2 (e )11.3 (pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 (.)-6.6 ( )33 (W)-36.3 (o)21.4 (r)-6 (l)2.6 (d J)-2 ( S)2 (u)10.5 (r)4.9 (g)-11.2 ( 2010)10.6 (;)-6.7 (34:)-6.7 (28)]TJ 0 Tc 0 Tw 31.293 0 Td (-)Tj -0.002 Tc 0.007 Tw -31.293 -1.152 Td [(35.)-6.6 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.3 (/)-6.6 (w)13.4 (w)2.7 (w)13.4 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.7 (nl)2.6 (m)-6 (.)-6.5 (ni)2.6 (h.)4.2 (g)-11.2 (ov)8.8 (/)-6.6 (pubm)-6 (ed/)-6.6 (20020290)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 715.08 156.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 486.48 154.92 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 133.32 Tm [(64.)-6.6 ( N)2.6 (euhol)2.6 (d N)2.6 (,)4.2 ( S)2 (c)-2 (hul)2.6 (t)-6.6 (hei)13.5 (s)-2 ( A)2 (,)]TJ 0 Tc 0 Tw 12.739 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(H)2.6 (er)4.9 (m)-6 (ann M)15.8 (,)-6.6 ( et)4.3 ( al)2.6 (.)4.3 ( I)-6.6 (n)10.5 (c)-2 (i)2.6 (dent)-6.6 (al)2.6 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( )]TJ -0.013 Tc 0.018 Tw -13.022 -1.141 Td [(m)-17 (i)-8.3 (c)-13.1 (r)-16.9 (o)-11.4 (c)-13 (ar)-17 (c)-13 (i)-8.4 (n)-11.3 (o)-11.4 (m)-16.9 (a of)-17.6 ( t)-17.6 (h)-11.4 (e t)-17.7 (hy)-2.2 (r)-16.9 (o)-11.4 (i)-8.4 (d)]TJ 0.004 Tc -0.004 Tw 13.065 0 Td (--)Tj -0.002 Tc 0.007 Tw 0.663 0 Td [(f)-17.5 (ur)4.9 (t)-6.6 (her)4.9 ( ev)8.9 (i)2.6 (denc)-2 (e o)10.6 (f)-6.6 ( a v)8.9 (er)-5.9 (y)8.8 ( l)2.6 (ow)13.5 ( m)-6 (al)2.6 (i)2.6 (g)-11.2 (nant)-6.6 ( )]TJ -13.728 -1.152 Td [(pot)-6.6 (ent)-6.6 (i)2.6 (al)2.6 (:)-6.6 ( a)10.5 ( r)-6 (e)10.5 (t)-6.6 (r)5 (os)-2 (pec)-2 (t)-6.6 (i)2.6 (v)8.9 (e c)-2 (l)2.7 (i)2.5 (ni)2.6 (c)-2 (opat)-6.6 (hol)2.6 (og)-11.2 (i)2.6 (c)-2 (al)2.6 ( s)8.9 (t)-6.6 (udy)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h up t)-6.6 (o)10.5 ( 30 y)8.8 (ear)-6 (s)8.9 ( o)10.5 (f)-6.6 ( )]TJ -0.005 Tc 0.005 Tw 0 -1.141 Td [(f)-9.6 (o)-3.4 (llo)-3.3 (w)]TJ 0 Tc 0 Tw 2.533 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up.)-6.6 ( A)2 (nn S)1.9 (ur)4.9 (g)-11.2 ( )11.2 (O)-6.6 (nc)8.8 (ol)2.6 ( 2011;)-6.6 (18:)-6.6 (3430)]TJ 0 Tc 0 Tw 15.087 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(3436.)4.3 ( A)12.8 (v)8.9 (ai)-8.2 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -18.293 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21431405)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 82.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 80.64 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 59.04 Tm [(65.)-6.6 ( )11.3 (T)-10.6 (a)10.5 (k)-12.8 (a)10.5 (m)-6 (i)2.6 ( H)2.6 (,)4.3 ( I)4.3 (t)-6.6 (o)10.5 ( Y)1.9 (,)-6.6 ( )11.3 (O)4.2 (k)-12.8 (a)10.5 (m)-6 (ot)-6.6 (o)10.5 ( )11.3 (T)-10.6 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( R)2.6 (ev)8.8 (i)2.6 (s)-2 (i)2.7 (t)-6.7 (i)2.7 (ng)-11.2 ( t)4.2 (he )11.2 (g)-11.2 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( i)2.6 (s)-2 (s)-2 (ued by)8.9 ( )]TJ 0 -1.141 Td [(t)-6.6 (he J)-2 (apanes)8.8 (e S)1.9 (oc)-2 (i)2.6 (et)-6.7 (y)8.9 ( o)10.6 (f)-6.7 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d S)2 (ur)4.9 (g)-11.2 (eons)8.9 ( and)10.5 ( J)8.8 (apan A)1.9 (s)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (i)2.6 (on o)10.6 (f)-6.6 ( )]TJ EMC ET endstream endobj 926 0 obj 28624 endobj %% Contents for page 105 %% Original object ID: 211 0 927 0 obj << /Length 928 0 R >> stream Q q BT /Xi103 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 928 0 obj 246 endobj %% Original object ID: 11516 0 929 0 obj [ 2722 0 R 2723 0 R 2724 0 R 2725 0 R 2726 0 R 2727 0 R 2728 0 R 2729 0 R 2730 0 R 2731 0 R 2732 0 R 2733 0 R 2734 0 R 2735 0 R 2736 0 R ] endobj %% Contents for page 106 %% Original object ID: 212 0 930 0 obj << /Length 931 0 R >> stream q endstream endobj 931 0 obj 2 endobj %% Contents for page 106 %% Original object ID: 11517 0 932 0 obj << /Length 933 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (43)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (ne S)1.9 (ur)4.9 (g)-11.2 (eons)8.9 (:)]TJ 0 Tc 0 Tw 9.315 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(a)10.5 ( )11.3 (gr)-5.9 (adual)2.6 ( m)-5.9 (ov)8.9 (e )11.3 (t)-6.6 (ow)13.5 (ar)-6 (ds)-2 ( c)-2 (o)10.5 (ns)-2 (ens)-2 (us)-2 ( be)10.5 (t)-6.6 (w)13.5 (een )]TJ -9.598 -1.152 Td [(J)-2 (apanes)-2 (e and)10.6 ( w)13.5 (es)-2 (t)-6.6 (er)-5.9 (n p)10.5 (r)-5.9 (ac)-2 (t)-6.6 (i)2.6 (c)-2 (e)10.6 ( i)2.6 (n t)-6.6 (he)10.5 ( m)-6 (ana)10.6 (gem)-6 (e)10.5 (nt)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (a.)4.3 ( )]TJ 0 -1.141 Td [(W)-25.4 (o)10.5 (r)4.9 (l)2.7 (d J)8.9 ( S)1.9 (ur)4.9 (g 2014;)-6.7 (38)10.5 (:)-6.6 (20)10.5 (02)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 12.467 0 Td [(2010.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -12.467 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (246)]TJ (71301)Tj EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 473.88 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 452.28 Tm [(66.)-6.6 ( )11.3 (I)-6.6 (t)-6.7 (o)10.6 ( Y)1.9 (,)4.3 ( U)2.6 (r)-6 (uno )11.3 (T,)4.2 ( N)2.6 (ak)-2 (a)10.5 (no K)2 (,)-6.6 ( e)10.5 (t)4.3 ( al)2.6 (.)-6.6 ( A)2 (n)10.5 ( obs)-2 (er)-5.9 (v)8.8 (at)-6.6 (i)13.5 (on t)4.2 (r)-5.9 (i)2.6 (al)2.6 ( w)13.5 (i)2.6 (t)-6.6 (hout)-6.6 ( s)-2 (ur)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( )]TJ 0 -1.141 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( i)2.6 (n pa)10.6 (t)-6.6 (i)2.6 (ent)-6.7 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( m)-5.9 (i)2.6 (c)-2.1 (r)-5.9 (oc)-2 (ar)-5.9 (c)-2 (i)2.6 (no)10.5 (m)5 (a o)10.5 (f)-6.6 ( t)-6.6 (he)10.5 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d.)4.2 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.7 (d )]TJ 0.002 Tw 0 -1.152 Td [(2003;)-6.6 (13:)-6.6 (381)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(387.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.7 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -5.88 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/)]TJ -0.002 Tc 0.002 Tw [(w)2.7 (w)2.6 (w)13.4 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.2 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (12804106)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 412.32 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 23.52 390.72 Tm [(67.)-6.6 ( T)-10.6 (an)10.6 ( )-10.6 (G)-6.6 (H)13.4 (,)-6.6 ( G)-6.6 (har)-6 (i)2.7 (b)10.5 ( )-10.6 (H)2.6 (.)-6.6 ( Thy)8.9 (r)-6 (oi)2.6 (d )-10.6 (i)2.6 (nc)-2 (i)2.6 (dent)-6.6 (al)2.6 (om)-6 (as)-2 (:)-6.6 ( m)4.9 (anag)-11.2 (e)10.5 (m)-6 (ent)4.2 ( )-10.6 (appr)-6 (oa)10.5 (c)-2 (hes)-2 ( )]TJ 0.007 Tw 0 -1.152 Td [(t)-6.6 (o nonpal)2.6 (pabl)2.6 (e nodul)2.7 (es)-2 ( )11.3 (di)2.6 (s)-2 (c)-2 (ov)8.9 (er)-5.9 (ed i)2.6 (nc)-2 (i)2.6 (dent)-6.6 (al)2.7 (l)2.6 (y)8.8 ( o)-11.2 (n t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d i)2.6 (m)-5.9 (a)10.5 (g)-11.2 (i)2.6 (n)10.5 (g)-11.2 (.)4.3 ( A)1.9 (nn )]TJ 0 -1.141 Td [(I)-6.6 (nt)-6.6 (e)10.6 (r)-6 (n M)15.7 (ed 1997;)-6.5 (126:)-6.6 (2)10.5 (2)10.5 (6)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 11.467 0 Td [(231.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -11.467 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9027275)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 350.76 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 329.16 Tm [(68.)-6.6 ( )11.3 (I)-6.6 (t)-6.7 (o)10.6 ( Y)1.9 (,)4.3 ( M)15.8 (i)-8.3 (y)8.9 (auc)-2 (hi)2.7 ( A)2 (,)-6.6 ( K)1.9 (i)2.7 (har)-6 (a M)15.8 (,)-6.7 ( et)4.2 ( al)2.6 (.)4.3 ( P)1.9 (at)-6.6 (i)2.6 (ent)4.2 ( a)10.6 (ge i)2.6 (s)-2 ( s)-2 (i)13.5 (g)-11.3 (ni)13.5 (f)-17.5 (i)2.6 (c)-2 (ant)-6.6 (l)2.6 (y)8.9 ( r)-6 (el)2.6 (at)-6.6 (ed)10.5 ( t)4.3 (o )]TJ 0 -1.152 Td [(t)-6.6 (he p)10.5 (r)-5.9 (o)10.5 (g)-11.2 (r)-6 (es)-2 (s)-2 (i)2.6 (on)10.5 ( )0.5 (o)10.5 (f)-6.6 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( m)-5.9 (i)2.6 (c)-2 (r)-6 (oc)-2 (a)10.5 (r)-6 (c)-2 (i)2.7 (nom)-6 (a)10.5 ( o)10.5 (f)-6.6 ( t)-6.6 (h)10.6 (e t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d under)4.9 ( )]TJ -0.004 Tw 0 -1.141 Td [(obs)-2 (er)-6 (v)8.9 (at)-6.6 (i)2.6 (on.)-6.6 ( T)-10.6 (hy)8.8 (r)-5.9 (oi)2.7 (d )-10.6 (201)10.5 (4;)-6.6 (24:)-6.6 (27)]TJ 0 Tc 0 Tw 14.293 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(34.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)]TJ 5.13 0 Td [(e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -19.761 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24001104)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 291.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 289.08 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 267.48 Tm [(69.)-6.6 ( K)1.9 (i)2.7 (m)4.9 ( H)2.6 (J)-2 (,)4.2 ( K)2 (i)2.6 (m)-5.9 ( N)2.6 (K)12.8 (,)-6.6 ( C)2.6 (h)10.5 (oi)2.6 ( J)-2 (H)2.6 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( R)2.6 (adi)2.6 (oac)-2 (t)-6.6 (i)2.6 (v)8.9 (e i)2.6 (odi)2.6 (ne abl)2.6 (at)-6.7 (i)2.7 (on does)-2 ( no)10.5 (t)-6.6 ( )]TJ 0 -1.141 Td [(pr)-6 (ev)8.9 (ent)-6.6 ( r)-5.9 (ec)-2 (u)10.5 (r)-5.9 (r)-6 (en)10.5 (c)-2 (es)-2 ( i)2.6 (n p)10.5 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d m)-5.9 (i)2.6 (c)-2 (r)-6 (oc)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.6 (.)-6.7 ( )0.5 (C)]TJ -0.005 Tc 0.005 Tw 31.587 0 Td [(lin)-3.3 ( )]TJ -0.002 Tc 0.007 Tw -31.587 -1.152 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( \()4.9 (O)-6.6 (x)8.9 (f)-6.7 (\))-5.9 ( 2013)10.5 (;)-6.6 (78)10.5 (:)-6.6 (614)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.359 0 Td [(620)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -13.359 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22957654)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 229.56 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 227.52 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 205.92 Tm [(70.)-6.6 ( N)2.6 (i)2.6 (l)2.6 (ubol)2.6 ( N)2.6 (,)-6.6 ( K)1.9 (ebebew)13.5 ( E)1.9 (.)-6.6 ( S)2 (houl)2.6 (d s)8.9 (m)-6 (al)2.6 (l)2.6 ( papi)2.7 (l)2.6 (l)2.6 (ar)-5.9 (y)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-6 ( be)10.5 ( )]TJ 0 -1.141 Td [(obs)-2 (er)-6 (v)8.9 (ed? A)2 ( popul)2.6 (at)-6.6 (i)2.6 (on)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 10.804 0 Td [(bas)-2 (ed s)-2 (t)-6.6 (u)]TJ [(dy)8.9 (.)4.2 ( C)2.7 (anc)-2 (er)4.9 ( 201)10.6 (5;)-6.6 (121:)-6.6 (1017)]TJ 0 Tc 0 Tw 16.065 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(1024.)4.3 ( )]TJ 0.007 Tw -27.207 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (25425528)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 180.6 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 178.56 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 156.96 Tm [(71.)-6.6 ( F)11.2 (r)-6 (at)-6.6 (es)8.9 ( M)15.8 (C)2.6 (,)-6.6 ( B)1.9 (ens)-2 (on )11.3 (C)2.6 (B)2 (,)-6.6 ( C)2.6 (har)-6 (boneau)10.5 ( J)19.7 (W)-25.3 (,)4.2 ( e)10.5 (t)-6.6 ( )11.3 (al)2.7 (.)-6.7 ( )0.5 (M)15.7 (anag)-11.2 (em)-5.9 (en)10.5 (t)-6.6 ( o)10.6 (f)-6.7 ( )11.3 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.141 Td [(nodul)2.6 (es)-2 ( det)-6.6 (ec)8.9 (t)-6.6 (ed a)10.5 (t)-6.6 ( U)2.6 (S)2 (:)4.2 ( )11.3 (S)1.9 (oc)-2 (i)2.6 (et)-6.6 (y)8.8 ( of)-6.6 ( R)]TJ 16.293 0 Td [(adi)2.6 (ol)2.6 (og)-11.2 (i)2.6 (s)-2 (t)4.3 (s)-2 ( i)13.5 (n U)2.6 (l)2.6 (t)-6.6 (r)-5.9 (as)-2 (ound)10.5 ( c)-2 (ons)-2 (ens)-2 (us)8.9 ( )]TJ -16.293 -1.152 Td [(c)-2 (on)10.5 (f)-17.5 (er)-6 (enc)-2 (e)10.5 ( s)8.9 (t)-6.6 (at)-6.6 (e)10.5 (m)-5.9 (ent)4.3 (.)-6.6 ( R)13.4 (adi)2.6 (ol)2.6 (og)-11.3 (y)8.9 ( 2005;)-6.6 (237:)-6.6 (794)]TJ 0 Tc 0 Tw 20.946 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(8)10.5 (00.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -21.283 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (16304103)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 119.04 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 117 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 95.4 Tm [(72.)-6.6 ( H)2.6 (au)10.5 (g)-11.2 (en B)1.9 (R)13.5 (,)-6.6 ( A)1.9 (l)2.7 (ex)8.9 (ander)-6 ( E)2 (K)2 (,)4.2 ( B)2 (i)2.6 (bl)2.7 (e K)2 (C)2.6 (,)-6.7 ( e)10.6 (t)-6.6 ( al)2.6 (.)4.3 ( 20)10.6 (15 )]TJ -0.004 Tw [(A)1.9 (m)-5.9 (e)10.5 (r)-6 (i)2.6 (c)-2 (an T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0.007 Tw 0 -1.152 Td [(A)2 (s)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (i)2.6 (on M)15.8 (anag)-11.2 (em)-6 (en)10.5 (t)-6.6 ( )11.2 (G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (or)4.9 ( A)1.9 (dul)2.7 (t)4.2 ( P)2 (at)4.3 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ -0.004 Tw 0 -1.141 Td [(N)2.6 (odul)2.6 (es)-2 ( )-10.6 (and )-10.6 (D)2.6 (i)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-6 (ent)-6.6 (i)2.6 (at)4.3 (ed T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (C)2.6 (anc)-2 (er)-5.9 (:)4.2 ( T)-10.6 (he)10.5 ( A)1.9 (m)-5.9 (er)-5.9 (i)2.6 (c)-2 (an T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0.007 Tw 0 -1.141 Td [(A)2 (s)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (i)2.6 (on G)-6.6 (ui)2.6 (del)2.6 (i)2.7 (nes)-2 ( )11.2 (Tas)-2 (k)-2 ( For)4.9 (c)-2 (e on)10.5 ( )11.3 (T)-10.6 (hy)8.9 (r)-5.9 (oi)2.6 (d N)2.6 (odul)2.7 (es)-2 ( and D)2.6 (i)13.5 (f)-6.7 (f)-17.4 (e)10.5 (r)-6 (ent)-6.6 (i)2.6 (a)10.6 (t)-6.6 (ed )]TJ -0.004 Tw 34.554 41.348 Td [(T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (C)2.6 (anc)-2 (er)4.9 (.)-6.6 ( T)-10.5 (hy)8.9 (r)-5.9 (oi)2.6 (d 2016;)-6.7 (26:)-6.6 (1)]TJ 0 Tc 0 Tw 15.402 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td (133)Tj 0.007 Tw [(.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e)-11.2 ( at)4.2 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -15.739 -1.152 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (26462967)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 639.24 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 499.2 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 477.6 Tm [(73.)-6.6 ( B)1.9 (o)10.6 (m)-6 (el)2.6 (i)2.6 ( S)1.9 (R)2.7 (,)-6.6 ( LeB)2 (eau)10.5 ( )11.3 (S)2 (O)-6.7 (,)4.3 ( Fer)4.9 (r)-6 (i)2.6 (s)-2 ( R)2.6 (L.)4.3 ( E)1.9 (v)8.9 (al)2.6 (uat)-6.7 (i)2.7 (on o)10.5 (f)-6.6 ( a )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d nodul)2.6 (e.)-6.6 ( )]TJ 0 -1.141 Td [(O)-6.6 (t)-6.6 (ol)2.6 (ar)-6 (y)8.9 (n)10.5 (g)-11.2 (ol)2.6 ( C)2.6 (l)2.6 (i)2.6 (n N)2.6 (or)-5.9 (t)-6.6 (h)10.5 ( A)12.8 (m)-6 ( )0.5 (2010)10.5 (;)-6.6 (43:)-6.6 (229)]TJ 0 Tc 0 Tw 17.391 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(238,)4.2 ( v)8.9 (i)2.6 (i)2.6 (.)-6.6 ( A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -17.728 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (20510711)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 452.28 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 450.24 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 428.64 Tm [(74.)-6.6 ( M)15.8 (az)-2 (z)8.9 (af)-17.4 (er)5 (r)-6 (i)2.6 ( E)2 (L.)4.3 ( )11.2 (T)-10.5 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-1.9 (anc)-2 (er)4.9 ( i)2.6 (n t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d nodul)13.4 (es)-2 (:)-6.6 ( )11.3 (f)-17.5 (i)2.6 (ndi)2.6 (n)10.5 (g a needl)2.7 (e i)2.6 (n)10.5 ( )]TJ 0 -1.141 Td [(t)-6.6 (he hay)8.9 (s)-2 (t)-6.6 (ac)8.9 (k)-2 (.)-6.6 ( A)12.8 (m)-6 ( )11.3 (J)-2 ( M)15.8 (ed 1992;)-6.6 (93:)-6.6 (359)]TJ 0 Tc 0 Tw 16.457 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(362.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -16.793 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (1415298)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 403.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 401.28 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 379.68 Tm [(75.)-6.6 ( H)2.6 (a)10.5 (m)-5.9 (m)-6 (i)2.6 (n)10.5 (g)-11.2 ( )11.3 (J)-2 (F,)4.3 ( G)-6.6 (os)-2 (l)2.6 (i)2.6 (n)10.6 (g)-11.3 (s)8.9 ( B)2 (M)15.7 (,)-6.6 ( v)8.9 (an S)2 (t)-6.6 (eeni)2.6 (s)-2 ( G)4.3 (J)-2 (,)4.2 ( )11.3 (et)-6.6 ( al)2.6 (.)4.3 ( )11.2 (T)-10.5 (he v)8.8 (al)2.6 (ue o)10.5 (f)-6.6 ( )11.3 (f)-17.5 (i)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 0 -1.141 Td [(needl)2.6 (e as)-2 (pi)2.6 (r)-6 (at)-6.6 (i)2.6 (on bi)2.6 (ops)-2 (y)8.8 ( )11.3 (i)2.6 (n pat)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h nodul)2.6 (ar)-5.9 ( t)4.2 (hy)8.9 (r)-6 (oi)2.6 (d di)2.6 (s)-2 (eas)-2 (e )0.5 (di)2.6 (v)8.9 (i)2.6 (ded )]TJ -0.004 Tw 0 -1.152 Td [(i)2.6 (nt)-6.6 (o g)-11.2 (r)-6 (oups)8.8 ( )-10.6 (o)10.6 (f)-6.7 ( )-10.6 (s)-2 (us)-2 (pi)2.6 (c)-2 (i)2.6 (on o)10.6 (f)-17.5 ( m)-6 (al)2.7 (i)2.6 (g)-11.3 (n)]TJ 0.007 Tw [(an)10.6 (t)-6.6 ( neopl)2.6 (as)8.9 (m)-5.9 (s)-2 ( )11.2 (on c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( g)-11.3 (r)-5.9 (ou)10.5 (nds)-2 (.)4.2 ( )0.5 (A)1.9 (r)-6 (c)-2 (h)10.6 ( )]TJ 0 -1.141 Td [(I)-6.6 (nt)-6.6 (e)10.6 (r)-6 (n M)15.7 (ed 1990;)-6.5 (150:)-6.6 (1)10.5 (1)10.5 (3)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 11.467 0 Td [(116.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -11.467 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (2297281)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 329.16 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 327.12 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 305.52 Tm [(76.)-6.6 ( C)2.6 (han B)1.9 (K)12.9 (,)-6.7 ( D)2.7 (es)-2 (s)-2 (e)10.5 (r)-5.9 ( )11.2 (T)-10.5 (S)12.8 (,)-6.6 ( M)15.8 (c)-2 (D)2.6 (oug)-11.2 (al)2.6 (l)2.6 ( I)-6.6 (R)2.6 (,)4.3 ( et)4.3 ( al)2.6 (.)4.2 ( C)2.6 (om)-6 (m)-5.9 (on)10.6 ( and un)10.5 (c)-2 (om)5 (m)-6 (on )]TJ 0.002 Tw 0 -1.152 Td [(s)-2 (onog)]TJ 0.007 Tw [(r)-5.9 (aphi)2.6 (c)-2 ( )11.3 (f)-6.6 (eat)-6.6 (u)10.5 (r)-6 (es)-2 ( o)10.5 (f)-6.6 ( )11.3 (papi)2.6 (l)2.7 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a.)4.3 ( J)-2 ( U)2.6 (l)2.6 (t)4.3 (r)-6 (as)-2 (ound)10.5 ( M)15.8 (ed )]TJ 0.002 Tw 0 -1.141 Td [(2003;)-6.6 (22:)-6.6 (1083)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1090.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (14606565)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 267.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 265.44 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 243.84 Tm [(77.)-6.6 ( H)2.6 (enr)-5.9 (y)8.8 ( J)-2 (F)11.2 (,)-6.6 ( D)2.6 (eni)2.6 (z)8.9 (ot)-6.6 ( A)2 (,)4.2 ( )0.5 (P)1.9 (uc)-2 (c)-1.9 (i)2.6 (ni)2.6 ( M)15.8 (,)-6.6 ( et)-6.6 ( al)2.6 (.)4.3 ( )11.2 ([)-6.6 (E)2 (ar)-5.9 (l)2.6 (y)8.9 ( di)2.6 (a)]TJ [(g)-11.2 (nos)-2 (i)2.6 (s)-2 ( o)10.5 (f)-6.6 ( s)-2 (po)10.6 (r)-6 (adi)2.6 (c)-2 ( )]TJ 0 -1.141 Td [(m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( c)-2 (anc)-2 (er)-5.9 (s)8.9 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.5 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d:)-6.6 ( v)8.9 (al)2.6 (ue o)10.6 (f)-6.6 ( s)-2 (y)8.9 (s)-2 (t)-6.6 (e)10.5 (m)5 (at)-6.6 (i)2.6 (c)-2 ( as)-2 (s)-2 (ay)8.9 ( o)10.5 (f)-6.6 ( c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n])4.3 (.)-6.6 ( )]TJ 0 -1.152 Td [(P)2 (r)-6 (es)-2.1 (s)-1.9 (e M)15.8 (ed 1996;)-6.6 (25)10.5 (:)-6.6 (15)10.5 (83)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 12.022 0 Td [(1588.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -12.022 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8952672)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 205.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 203.88 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 182.28 Tm [(78.)-6.6 ( C)2.6 (heun)10.5 (g)-11.2 ( K)12.8 (,)-6.6 ( R)2.6 (o)10.5 (m)-5.9 (an S)12.8 (A)2 (,)-6.7 ( )22.2 (W)-36.3 (a)10.5 (n)10.6 (g )11.3 (T)-10.6 (S)2 (,)4.2 ( et)4.2 ( )0.5 (al)2.6 (.)4.3 ( C)2.6 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.7 (n m)-5.9 (eas)-2 (u)10.5 (r)-6 (em)-6 (en)10.5 (t)-6.6 ( i)2.6 (n )11.2 (t)-6.6 (he)10.5 ( )]TJ 0 -1.141 Td [(ev)8.8 (al)2.6 (uat)-6.6 (i)2.6 (on of)-6.5 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d nod)10.5 (ul)2.6 (es)-2 ( i)2.6 (n t)-6.6 (he)10.5 ( U)2.6 (ni)2.7 (t)-6.7 (ed S)12.9 (t)-6.6 (at)-6.6 (es)8.8 (:)4.3 ( a c)-2 (os)8.9 (t)]TJ 0 Tc 0 Tw 24.88 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(e)10.5 (f)-6.6 (f)-6.6 (e)10.5 (c)-2 (t)-6.6 (i)2.6 (v)8.9 (enes)-2 (s)-2 ( )]TJ 0.007 Tw -25.217 -1.152 Td [(and dec)-2 (i)2.6 (s)-2 (i)2.6 (on anal)2.7 (y)8.8 (s)-2 (i)2.6 (s)-2 (.)-6.6 ( J)-2 ( )11.3 (C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.6 (nol)2.6 ( M)15.7 (et)-6.6 (ab 2008;)-6.6 (93:)-6.6 (2173)]TJ 0 Tc 0 Tw 26.924 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(2180.)4.3 ( )]TJ 0.007 Tw -27.261 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (18364376)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 144.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 142.32 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 120.72 Tm [(79.)-6.6 ( D)2.6 (oy)8.8 (l)2.6 (e P)1.9 (,)-6.6 ( D)2.7 (ur)-6 (en)10.5 ( C)2.6 (,)4.3 ( N)13.5 (er)-5.9 (l)2.6 (i)2.6 (c)-2 (h K)2 (,)-6.6 ( e)10.5 (t)-6.6 ( al)13.5 (.)-6.6 ( P)2 (o)10.5 (t)-6.6 (enc)-2 (y)8.9 ( and t)-6.6 (ol)2.6 (er)-5.9 (anc)-2 (e)10.5 ( o)10.5 (f)-6.6 ( c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n)10.5 ( )]TJ 0 -1.152 Td [(s)-2 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (at)-6.6 (i)2.6 (on w)13.5 (i)2.6 (t)-6.6 (h hi)13.5 (g)-11.2 (h)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.315 0 Td [(dos)8.9 (e c)-2 (al)2.6 (c)-2 (i)2.6 (um)-6 ( v)8.9 (er)-5.9 (s)-2 (us)8.9 ( pent)-6.7 (a)10.6 (gas)-2 (t)-6.6 (r)-6 (i)2.6 (n i)2.6 (n)10.5 ( nor)4.9 (m)-5.9 (al)2.6 ( adul)2.6 (t)-6.6 (s)8.9 (.)-6.7 ( J)8.9 ( )]TJ -9.315 -1.141 Td [(C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.7 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2009;)-6.6 (94:)-6.6 (297)]TJ 0 Tc 0 Tw (0)Tj 16.12 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(2974.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -16.457 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19491231)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 82.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 80.64 228.72 0.84 re f EMC endstream endobj 933 0 obj 25926 endobj %% Contents for page 106 %% Original object ID: 213 0 934 0 obj << /Length 935 0 R >> stream Q q BT /Xi104 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 935 0 obj 246 endobj %% Original object ID: 11534 0 936 0 obj [ 2737 0 R 2738 0 R 2739 0 R 2740 0 R 2741 0 R 2742 0 R 2743 0 R 2744 0 R 2745 0 R 2746 0 R 2747 0 R 2748 0 R 2749 0 R 2750 0 R ] endobj %% Contents for page 107 %% Original object ID: 214 0 937 0 obj << /Length 938 0 R >> stream q endstream endobj 938 0 obj 2 endobj %% Contents for page 107 %% Original object ID: 11535 0 939 0 obj << /Length 940 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (44)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(80.)-6.6 ( C)2.6 (i)2.6 (bas)-2 ( E)2 (S)1.9 (,)4.3 ( A)1.9 (l)2.7 (i)2.6 ( S)1.9 (Z.)4.3 ( )11.2 (T)-10.5 (h)10.5 (e 2017 B)1.9 (e)10.6 (t)-6.7 (hes)-2 (da S)1.9 (y)8.9 (s)-2 (t)-6.6 (e)10.5 (m)-6 ( )11.3 (f)-6.6 (or)4.9 ( R)2.6 (epor)5 (t)-6.7 (i)2.6 (ng )11.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ -0.004 Tw 0 -1.152 Td [(C)2.6 (y)8.9 (t)-6.6 (opat)-6.6 (hol)2.6 (og)-11.2 (y)8.8 (.)-6.5 ( T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (2)10.5 (017;)-6.6 (27:)-6.6 (1341)]TJ 0 Tc 0 Tw 16.62 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1346.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -16.957 -1.141 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (29091573)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.76 488.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 486.6 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 465 Tm [(81.)-6.6 ( E)1.9 (i)2.7 (l)2.6 (er)-5.9 (s)-2 ( S)12.8 (G)-6.6 (,)4.2 ( LaP)2 (ol)2.6 (i)2.6 (c)-2 (e )11.3 (P)2 (,)-6.7 ( )0.5 (M)15.7 (uk)-12.9 (uny)8.9 (adz)8.9 (i)2.6 ( P)1.9 (,)-6.6 ( et)-6.6 ( al)2.6 (.)4.3 ( )11.3 (Thy)8.9 (r)-6 (oi)2.6 (d f)-17.4 (i)2.6 (ne)]TJ 0 Tc 0 Tw 26.196 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(needl)2.6 (e )]TJ 0.007 Tw -26.533 -1.152 Td [(as)-2 (pi)2.6 (r)-5.9 (at)-6.6 (i)2.6 (on c)-2 (y)8.9 (t)-6.6 (ol)2.7 (o)10.5 (g)-11.2 (y)8.8 (:)-6.6 ( per)4.9 (f)-6.6 (o)10.5 (r)-5.9 (m)-6 (anc)-2 (e)10.6 ( dat)-6.6 (a)10.5 ( o)10.5 (f)-6.6 ( neopl)2.6 (as)-2 (t)-6.6 (i)13.4 (c)-2 ( and )11.3 (m)-6 (al)2.6 (i)2.6 (g)-11.2 (nan)10.5 (t)-6.6 ( c)-2 (a)10.5 (s)-2 (es)-2 ( )]TJ 0 -1.141 Td [(as)-2 ( i)2.6 (dent)-6.6 (i)13.5 (f)-17.5 (i)]TJ 4.217 0 Td [(ed )11.3 (f)-6.6 (r)-6 (o)10.5 (m)-5.9 ( 15)10.6 (58 )11.3 (r)4.9 (es)-2 (pons)-2.1 (es)-2 ( i)2.6 (n )11.2 (t)-6.6 (he A)2 (S)1.9 (C)2.6 (P)2 ( N)13.5 (on)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 18.88 0 Td [(G)-6.6 (Y)1.9 (N)2.7 ( A)1.9 (s)8.9 (s)-2 (es)-2 (s)8.9 (m)-5.9 (ent)4.2 ( )]TJ -0.004 Tw -23.098 -1.152 Td [(pr)-6 (o)10.5 (g)-11.2 (r)-5.9 (a)10.5 (m)-6 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d f)-17.5 (i)2.7 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.207 0 Td [(nee)10.5 (dl)2.6 (e per)5 (f)-17.5 (o)10.5 (r)-6 (m)-5.9 (an)10.6 (c)-2 (e da)10.5 (t)-6.6 (a.)4.3 ( C)13.5 (anc)-2 (er)-5.9 ( C)2.6 (y)8.9 (t)-6.7 (opat)-6.6 (hol)2.6 ( )]TJ 0.002 Tw -9.207 -1.141 Td [(2014;)-6.6 (122:)-6.6 (745)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(750.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24913410)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 401.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 399.72 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn 11.04 -0 0 11.04 23.52 378 Tm (8)Tj -0.002 Tc 0.007 Tw 0.554 0 Td [(2.)-6.6 ( Y)2 (eh)10.5 ( M)37.5 (W)-36.3 (,)4.3 ( D)2.6 (em)-6 (i)2.6 (r)-5.9 (c)-2 (an)10.5 ( )11.3 (O)-6.6 (,)4.2 ( )0.5 (I)4.2 (t)-6.6 (uar)4.9 (t)-6.6 (e P)12.8 (,)-6.6 ( C)2.6 (l)2.6 (ar)4.9 (k)-2 ( )11.2 (O)-6.6 (H)2.6 (.)-6.6 ( F)11.2 (al)2.7 (s)-2 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 23.098 0 Td [(neg)-11.2 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e f)-17.5 (i)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 5.989 0 Td [(needl)13.5 (e )]TJ 0.007 Tw -29.641 -1.141 Td [(as)-2 (pi)2.6 (r)-5.9 (at)-6.6 (i)2.6 (on c)-2 (y)8.9 (t)-6.6 (ol)2.7 (o)10.5 (g)-11.2 (y)8.8 ( r)-5.9 (es)-2 (ul)2.6 (t)4.3 (s)-2.1 ( del)2.7 (ay)8.9 ( t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-6 (en)10.5 (t)-6.6 ( and)10.5 ( ad)10.5 (v)8.9 (er)-5.9 (s)-2 (el)2.6 (y)8.9 ( af)-6.7 (f)-17.4 (ec)8.9 (t)-6.6 ( ou)10.5 (t)-6.6 (c)-1.9 (o)10.5 (m)-6 (e )]TJ 0 -1.141 Td [(i)2.6 (n pat)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)8.9 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a.)4.3 ( )11.3 (T)-10.6 (hy)8.9 (r)-5.9 (oi)2.6 (d 2004;)4.2 (14:)-6.6 (207)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 24.772 0 Td [(215)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -24.772 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (15072703)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 340.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 338.04 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 23.52 316.44 Tm [(83.)-6.6 ( G)-6.6 (i)2.6 (or)-5.9 (dano TJ)-2 (,)4.2 ( )-10.6 (B)2 (eaud)10.5 (enon)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.13 0 Td [(H)2.6 (ui)2.6 (br)-5.9 (egt)-6.6 (s)-2 (e)10.5 ( S)1.9 (,)4.3 ( S)1.9 (hi)2.6 (nde R)2.6 (,)-6.6 ( e)10.5 (t)-6.6 ( )11.3 (al)2.6 (.)-6.6 ( M)15.8 (ol)2.6 (ec)-2 (ul)2.6 (ar)-5.9 ( )]TJ -13.13 -1.141 Td [(t)-6.6 (es)-2 (t)-6.6 (i)2.7 (n)10.5 (g)-11.2 ( )11.2 (f)-6.6 (or)4.9 ( onc)-2 (o)10.5 (g)-11.2 (eni)2.6 (c)8.9 ( )11.3 (g)-11.3 (e)10.5 (ne m)-5.9 (u)10.5 (t)-6.6 (at)-6.6 (i)2.6 (ons)8.8 ( i)2.7 (n t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d l)2.6 (e)10.5 (s)-2 (i)2.6 (ons)-2 (:)-6.6 ( a)10.5 ( c)-2 (as)-2 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 27.804 0 Td [(c)-2 (ont)4.3 (r)-6 (ol)2.6 ( )]TJ 0.007 Tw -27.804 -1.152 Td [(v)8.9 (al)-8.2 (i)2.6 (dat)-6.6 (i)2.6 (on s)-2 (t)-6.6 (udy)8.8 ( )0.5 (i)2.6 (n 413 p)10.5 (os)-2 (t)-6.6 (s)-2 (ur)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( )11.2 (s)-2 (pec)-2 (i)2.6 (m)-5.9 (ens)8.9 (.)-6.6 ( )]TJ [(H)13.4 (um)-6 ( P)2 (a)10.5 (t)-6.6 (hol)2.6 ( )]TJ 0.002 Tw 0 -1.141 Td [(2014;)-6.6 (45:)-6.6 (1339)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1347.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24830619)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 265.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 263.88 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 242.16 Tm [(84.)-6.6 ( A)1.9 (l)2.7 (ex)8.9 (ander)-6 ( E)2 (K)2 (,)4.2 ( K)2 (ennedy)8.9 ( G)-6.6 (C)2.6 (,)-6.6 ( B)2 (al)2.6 (oc)-2 (h )11.3 (Z)22 (W)-25.3 (,)4.2 ( e)10.5 (t)-6.6 ( a)10.5 (l)2.6 (.)-6.6 ( P)2 (r)-6 (eope)10.5 (r)-5.9 (at)-6.6 (i)2.6 (v)8.9 (e di)2.6 (ag)-11.3 (nos)-2 (i)2.7 (s)8.8 ( )]TJ 0 -1.141 Td [(o)10.5 (f)-17.5 ( beni)13.5 (g)-11.2 (n )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d nodul)2.6 (es)-2 ( w)13.5 (i)2.6 (t)-6.6 (h i)2.6 (ndet)]TJ 15.63 0 Td [(er)4.9 (m)-6 (i)2.6 (nat)-6.6 (e c)-2 (y)8.8 (t)-6.6 (o)10.6 (l)2.6 (og)-11.2 (y)8.9 (.)-6.6 ( N)2.6 ( E)1.9 (n)10.6 (g)-11.3 (l)2.7 ( J)8.9 ( M)15.8 (ed )]TJ 0.002 Tw -15.63 -1.141 Td [(2012;)-6.6 (367:)-6.6 (705)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(715.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22731672)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 204.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 202.2 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 180.6 Tm [(85.)-6.6 ( N)2.6 (i)13.5 (k)-12.9 (i)13.5 (f)-17.5 (or)-6 (ov)8.8 ( Y)2 (E)2 (,)4.2 ( )11.3 (O)-6.6 (hor)-6 (i)2.6 ( )11.3 (N)2.6 (P)2 (,)-6.7 ( H)2.7 (oda)10.5 (k)-12.9 ( S)2 (P)1.9 (,)4.3 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( I)4.3 (m)-6 (p)10.6 (ac)-2 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (m)-6 (ut)4.2 (at)-6.6 (i)2.6 (onal)2.7 ( t)-6.6 (e)10.5 (s)-2 (t)-6.6 (i)2.6 (n)10.5 (g)-11.2 ( )]TJ 0 -1.141 Td [(on t)-6.6 (he)10.6 ( di)2.6 (ag)-11.2 (no)]TJ 6.043 0 Td [(s)-2 (i)2.6 (s)-2 ( and )11.2 (m)-5.9 (a)10.5 (nag)-11.2 (e)10.5 (m)-5.9 (ent)4.2 ( o)10.5 (f)-6.6 ( pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h c)-2 (y)8.9 (t)-6.6 (ol)2.6 (og)-11.2 (i)2.6 (c)-2 (al)2.6 (l)2.6 (y)8.9 ( )]TJ -6.043 -1.152 Td [(i)2.6 (ndet)-6.6 (er)-5.9 (m)-6 (i)2.6 (na)10.5 (t)-6.6 (e )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d nodul)2.6 (es)-2 (:)-6.6 ( )0.5 (a p)10.5 (r)-6 (os)-2 (pec)8.9 (t)-6.6 (i)2.6 (v)8.9 (e anal)2.6 (y)8.8 (s)-2 (i)2.7 (s)-2 ( of)-6.6 ( 1056 FN)2.6 (A)12.9 ( )]TJ 0 -1.141 Td [(s)-2 (am)-6 (pl)2.7 (es)-2 (.)4.3 ( J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)2 (ndoc)8.8 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2011;)-6.7 (96:)-6.6 (3390)]TJ 0 Tc 0 Tw 21.163 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(3)10.5 (397.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -21.5 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)]TJ -0.002 Tc 0.002 Tw 6.533 0 Td [(i)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.8 (/)-6.6 (pubm)-5.9 (ed/)-6.7 (21880806)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 130.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 128.04 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 106.32 Tm [(86.)-6.6 ( )11.3 (O)-6.6 (hor)-6 (i)2.6 ( N)2.6 (P)12.9 (,)-6.7 ( N)2.7 (i)13.4 (k)-12.8 (i)13.4 (f)-17.4 (or)-5.9 (ov)8.9 (a )11.3 (M)4.9 (N)2.6 (,)-6.6 ( S)2 (c)-2 (hoedel)2.7 ( K)2 (E)2 (,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( )11.3 (C)2.6 (ont)-6.6 (r)-6 (i)2.6 (but)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( )]TJ -0.004 Tw 0 -1.141 Td [(m)-6 (ol)2.6 (ec)-2 (ul)2.6 (ar)-6 ( t)-6.6 (es)-2 (t)-6.6 (i)2.6 (n)10.6 (g )-10.6 (t)-6.6 (o)10.5 ( )-10.6 (t)-6.6 (hy)8.8 (r)4.9 (oi)2.6 (d f)-17.5 (i)2.7 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.13 0 Td [(needl)2.6 (e as)-2 (pi)2.6 (r)-6 (a)10.5 (t)-6.5 (i)2.5 (o)10.6 (n c)-2 (y)8.9 (t)-6.6 (ol)2.7 (og)-11.2 (y)8.9 ( o)10.5 (f)-6.6 ( ")5.2 (f)-6.7 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( )]TJ -14.13 -1.141 Td [(l)2.6 (es)-2 (i)2.6 (on o)10.5 (f)-17.5 ( unde)10.5 (t)-6.6 (er)5 (m)-6 (i)2.6 (ned s)-2 (i)13.4 (g)-11.2 (ni)13.5 (f)-17.5 (i)2.6 (c)-2 (anc)-2 (e)10.5 (/)-6.6 (at)-6.6 (y)8.8 (pi)2.6 (a o)10.5 (f)-6.6 ( unde)10.5 (t)-6.6 (er)4.9 (m)-5.9 (i)2.6 (ned s)-2 (i)13.5 (g)-11.2 (ni)13.5 (f)-17.5 (i)2.6 (c)-2 (anc)-2 (e")5.2 (.)-6.6 ( )]TJ 0 -1.152 Td [(C)2.6 (anc)-2 (er)-6 ( C)2.6 (y)8.9 (t)]TJ 4.989 0 Td [(opat)-6.7 (hol)2.6 ( 2010)10.6 (;)4.2 (118:)-6.6 (17)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.424 0 Td [(23)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.413 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (20099311)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 55.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 53.76 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(87.)-6.6 ( R)2.6 (i)2.6 (v)8.9 (er)-5.9 (a M)15.8 (,)-6.6 ( R)2.6 (i)2.6 (c)-2 (ar)-6 (t)-6.6 (e)]TJ 0 Tc 0 Tw 9.359 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(Fi)2.6 (l)2.6 (ho J)-2 (,)4.3 ( K)1.9 (nau)10.6 (f)-6.6 ( J)-2 (,)4.2 ( e)10.6 (t)-6.7 ( al)2.6 (.)4.3 ( M)15.8 (ol)2.6 (e)-11.2 (c)-2 (ul)2.6 (ar)-5.9 ( )11.2 (g)-11.2 (enot)-6.7 (y)8.9 (pi)2.6 (ng o)10.5 (f)-6.6 ( )]TJ -9.696 -1.152 Td [(papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-6 (a )11.2 (f)-6.6 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( v)8.9 (ar)]TJ 17.446 0 Td [(i)2.6 (ant)-6.6 ( ac)-2 (c)-2 (o)10.5 (r)-6 (di)2.6 (ng t)-6.6 (o)10.5 ( i)2.6 (t)-6.6 (s)8.9 ( hi)2.6 (s)-2 (t)-6.6 (ol)2.6 (o)10.5 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( )]TJ -17.446 -1.141 Td [(s)-2 (ubt)-6.6 (y)8.9 (pes)-2 ( \()-6 (enc)-2 (aps)-2 (ul)2.6 (a)10.5 (t)-6.6 (ed )11.3 (v)8.8 (s)-1.9 ( i)2.7 (nf)-17.5 (i)2.7 (l)2.6 (t)-6.7 (r)-5.9 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e\))-5.9 ( r)-6 (ev)8.9 (eal)2.7 (s)-2 ( di)2.6 (s)-2 (t)-6.6 (i)2.6 (nc)-2 (t)-6.6 ( B)1.9 (R)2.7 (A)1.9 (F and)10.5 ( R)2.6 (A)2 (S)2 ( )]TJ 0 -1.152 Td [(m)-6 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (on pat)4.3 (t)-6.6 (er)5 (ns)-2 (.)4.3 ( M)15.7 (od P)2 (at)-6.7 (hol)2.7 ( 2010;)-6.6 (23)10.6 (:)-6.7 (1191)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 20.011 0 Td [(12)10.5 (00.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -20.011 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)]TJ 12.402 0 Td [(pubm)-6 (ed/)-6.6 (20526288)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 463.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 461.28 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 439.68 Tm [(88.)-6.6 ( N)2.6 (i)13.5 (k)-12.9 (i)13.5 (f)-17.5 (or)-6 (ov)8.8 ( Y)2 (E)2 (,)4.2 ( S)2 (t)-6.6 (ew)13.5 (ar)-6 (d D)2.6 (L,)-6.6 ( R)2.6 (obi)2.6 (ns)-2 (on)]TJ 0 Tc 0 Tw 17.674 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(S)2 (m)-6 (i)2.6 (t)-6.6 (h)10.5 ( )11.3 (TM)15.8 (,)-6.6 ( et)-6.6 ( al)2.6 (.)-6.6 ( M)15.8 (ol)2.6 (ec)-2 (ul)2.6 (ar)-6 ( t)-6.6 (es)8.8 (t)-6.6 (i)2.6 (ng )]TJ -18.011 -1.152 Td [(f)-6.6 (or)5 ( m)-6 (u)10.5 (t)-6.6 (at)-6.6 (i)2.6 (ons)8.9 ( i)2.7 (n i)2.6 (m)-5.9 (p)10.5 (r)-6 (ov)8.8 (i)2.7 (n)-11.3 (g t)-6.6 (he)10.6 ( )11.2 (f)-17.5 (i)2.7 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 15.304 0 Td [(needl)2.6 (e)10.5 ( as)-2 (pi)2.7 (r)-6 (at)-6.5 (i)13.4 (on di)2.6 (ag)-11.2 (nos)-2 (i)2.6 (s)8.9 ( o)10.5 (f)-6.6 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ -15.304 -1.141 Td [(nodul)2.6 (es)-2 (.)-6.6 ( J)8.8 ( C)2.6 (l)2.7 (i)2.6 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2009;)-6.6 (94:)-6.6 (2092)]TJ 0 Tc 0 Tw 20.946 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(2)10.5 (098.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -21.283 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19318445)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 401.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 399.72 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 378 Tm [(89.)-6.6 ( M)15.8 (us)-2 (hol)2.6 (t)-6.5 ( )11.2 (T)-10.6 (J)-2 (,)4.3 ( Fot)4.2 (t)-6.6 (ner)4.9 ( )11.3 (C)2.6 (,)-6.6 ( )22.1 (W)-36.2 (e)10.5 (be)10.6 (r)-6 ( M)15.8 (M)15.8 (,)-6.6 ( et)-6.6 ( al)2.6 (.)-6.6 ( D)2.6 (e)10.5 (t)4.3 (ec)-2 (t)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( by)8.9 ( anal)2.6 (y)8.8 (s)-2 (i)2.6 (s)-2 ( of)-6.6 ( B)2 (R)2.5 (A)2 (F and R)2.6 (E)12.8 (T)-10.6 (/)-6.6 (P)12.9 (T)-10.6 (C)2.6 (1)10.5 ( m)4.9 (ut)-6.6 (at)-6.6 (i)2.6 (ons)-2 ( i)2.7 (n)10.5 ( )11.3 (f)-17.5 (i)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 28.761 0 Td [(needl)2.6 (e)10.5 ( )]TJ 0.007 Tw -28.761 -1.141 Td [(as)-2 (pi)2.6 (r)-5.9 (at)-6.6 (i)2.6 (on bi)2.6 (ops)-2 (i)2.6 (es)-2 ( o)10.6 (f)-6.6 ( )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.5 (d n)]TJ [(odul)2.6 (es)-2 (.)4.2 ( )22.2 (W)-36.3 (o)10.5 (r)-5.9 (l)2.6 (d)10.5 ( J)-2 ( S)2 (u)10.5 (r)-6 (g 2010)10.5 (;)-6.6 (34:)-6.6 (2595)]TJ 0 Tc 0 Tw 29.087 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(2603.)4.3 ( )]TJ 0.007 Tw -29.424 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (20652698)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 340.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 338.04 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 316.44 Tm [(90.)-6.6 ( Las)-2 (s)-2 (al)2.7 (l)2.6 (e S)12.9 (,)-6.7 ( H)2.7 (o)10.5 (f)-6.6 (m)-6 (an)10.5 ( )11.2 (V)2 (,)-6.6 ( I)-6.6 (l)2.6 (i)2.6 (e M)15.8 (,)-6.7 ( et)4.3 ( al)2.6 (.)4.3 ( C)2.6 (l)2.6 (i)2.6 (ni)2.7 (c)-2 (al)2.6 ( i)-8.3 (m)-5.9 (pac)-2 (t)4.3 ( o)10.5 (f)-6.6 ( t)4.2 (he de)10.5 (t)-6.6 (ec)-2 (t)-6.6 (i)2.6 (on)10.5 ( o)10.6 (f)-6.6 ( )]TJ 0 -1.141 Td [(B)2 (R)2.6 (A)1.9 (F m)-5.9 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.7 (ons)-1.9 ( i)2.7 (n )11.3 (t)-6.6 (h)]TJ [(y)8.9 (r)-6 (oi)2.6 (d )0.5 (pat)-6.7 (hol)2.6 (o)10.5 (g)-11.2 (y)8.8 (:)-6.6 ( po)10.5 (t)-6.6 (ent)-6.6 (i)2.6 (al)2.6 ( us)8.9 (e)10.5 (f)-17.5 (ul)2.6 (nes)-2 (s)-2 ( as)8.8 ( di)2.6 (ag)-11.2 (no)10.5 (s)-2 (t)-6.6 (i)2.6 (c)8.9 (,)-6.6 ( )]TJ 0 -1.152 Td [(pr)-6 (o)10.5 (g)-11.2 (nos)-2 (t)-6.6 (i)2.6 (c)8.9 ( and )11.3 (t)-6.6 (her)-6 (a)10.6 (g)-11.2 (no)10.5 (s)-2 (t)-6.6 (i)2.6 (c)-2 ( appl)2.6 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (ons)-2 (.)4.2 ( C)2.6 (ur)4.9 (r)-5.9 ( M)15.7 (ed C)2.6 (hem)4.9 ( 2010;)-6.6 (17)10.6 (:)-6.7 (1839)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 0 -1.141 Td [(1850.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.3 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.7 (nc)-2 (bi)2.6 (.)-6.7 (nl)2.6 (m)-5.9 (.)-6.7 (ni)2.6 (h.)-6.6 (g)-11.3 (ov)8.9 (/)-6.7 (pu)10.5 (bm)-6 (ed/)-6.6 (20345340)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 727.32 278.52 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 498.72 276.48 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 254.88 Tm [(91.)-6.6 ( C)2.6 (hudo)]TJ [(v)8.9 (a D)2.7 (,)4.2 ( )22.1 (W)-36.2 (i)2.6 (l)2.6 (de)10.5 ( J)8.9 (I)-6.7 (,)4.3 ( )22.1 (W)-36.2 (a)10.5 (n)10.5 (g E)1.9 (T,)-6.6 ( )11.3 (et)4.3 ( al)2.6 (.)-6.6 ( M)15.7 (ol)2.6 (ec)-2 (ul)-8.3 (ar)-6 ( c)-2 (l)2.7 (as)-2 (s)-2 (i)13.5 (f)-17.5 (i)2.6 (c)-2 (a)10.5 (t)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( )]TJ 0 -1.152 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d nodul)2.6 (es)-1.9 ( us)-2 (i)2.6 (n)10.5 (g)-11.2 ( hi)13.5 (gh)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 11.913 0 Td [(di)2.6 (m)-6 (ens)-2 (i)2.6 (onal)2.6 (i)2.6 (t)-6.6 (y)8.9 ( g)-11.3 (eno)10.6 (m)-6 (i)2.6 (c)-2 ( dat)-6.6 (a)10.5 (.)-6.6 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( )]TJ -11.913 -1.141 Td [(M)15.8 (et)-6.6 (ab 2010;)-6.6 (95:)-6.6 (5296)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.489 0 Td [(53)10.5 (04.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -9.489 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)6.6 (l)9.6 (m)1.1 (.n)6.6 (i)9.7 (h)]TJ -0.002 Tc 0.002 Tw 10.25 0 Td [(.)4.3 (gov)8.8 (/)-6.6 (pubm)-6 (ed/)-6.6 (20826580)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 216.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 214.92 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 193.32 Tm [(92.)-6.6 ( Y)1.9 (ar)4.9 (c)-2 (hoan M)15.8 (,)-6.6 ( Li)2.6 (V)1.9 (ol)2.6 (s)-2 (i)2.6 ( V)2 (A)1.9 (,)-6.6 ( B)2 (r)-6 (os)-2.1 (e)10.6 ( M)15.8 (S)1.9 (.)-6.6 ( B)2 (R)2.6 (A)1.9 (F m)5 (ut)-6.6 (at)-6.6 (i)2.6 (on and)10.6 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (an)10.5 (c)8.9 (er)-6 ( )]TJ 0 -1.152 Td [(r)-6 (ec)-2 (ur)5 (r)-6 (enc)-2 (e.)4.2 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n O)-6.6 (nc)-2 (ol)2.6 ( )11.3 (2015;)-6.6 (33:)-6.6 (7)]TJ 0 Tc 0 Tw 15.402 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(8.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -15.739 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (25422487)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 168 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 165.96 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 144.36 Tm [(93.)-6.6 ( Li)]TJ 0 Tc 0 Tw 2.446 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(C)13.5 (,)-6.6 ( Lee)10.5 ( K)1.9 (C)2.7 (,)-6.7 ( S)2 (c)-2 (hnei)13.5 (der)-5.9 ( E)1.9 (B)2 (,)4.3 ( Zei)2.6 (g)-11.2 (e)10.5 (r)-5.9 ( M)15.8 (A)1.9 (.)-6.6 ( B)2 (R)2.6 (A)12.8 (F V)2 (600E)2 ( m)-6 (u)10.5 (t)-6.6 (a)10.6 (t)-6.7 (i)2.7 (on and i)2.6 (t)4.3 (s)-2 ( )]TJ -2.728 -1.152 Td [(as)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (i)2.6 (on w)13.5 (i)2.6 (t)-6.6 (h c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (opat)-6.7 (hol)2.7 (og)-11.2 (i)2.6 (c)-2 (al)2.6 ( )11.2 (f)-6.6 (eat)-6.6 (u)10.5 (r)-5.9 (es)8.8 ( o)10.5 (f)-6.6 ( p)10.5 (api)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)-6 (:)-6.6 ( a)10.5 ( )]TJ 0.002 Tw 0 -1.141 Td [(m)-6 (et)-6.6 (a)]TJ 0 Tc 0 Tw 2.217 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(anal)2.6 (y)8.9 (s)-2.1 (i)2.7 (s)-2 (.)-6.7 ( J)-1.9 ( C)2.7 (l)2.6 (i)2.6 (n E)2 (n)10.5 (doc)-2 (r)-6 (i)2.7 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2012;)-6.6 (97:)4.3 (4559)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 21.38 0 Td [(4570.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -23.935 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (23055546)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 106.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 104.28 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 82.68 Tm [(94.)-6.6 ( B)1.9 (as)-2 (ol)2.6 (o F)11.2 (,)-6.6 ( )11.2 (T)-10.5 (o)10.5 (r)-6 (r)-5.9 (e)10.5 (gr)-6 (os)-2 (s)8.9 (a L,)4.3 ( G)-6.6 (i)2.6 (anni)2.6 (ni)2.6 ( R)2.6 (,)4.3 ( et)4.2 ( al)2.6 (.)-6.6 ( C)2.6 (o)10.5 (r)-5.9 (r)-6 (el)2.6 (at)-6.6 (i)2.6 (on be)10.5 (t)-6.6 (w)13.5 (een t)-6.6 (he )]TJ 0 -1.141 Td [(B)2 (R)2.6 (A)1.9 (F V)2 (600E)2 ( m)-6 (u)10.6 (t)-6.7 (at)-6.6 (i)2.6 (on a)10.5 (nd t)-6.6 (u)10.5 (m)-5.9 (or)4.9 ( i)2.6 (nv)8.9 (as)-2 (i)2.6 (v)8.8 (enes)-2 (s)-2 ( i)2.6 (n)-11.2 ( papi)2.6 (l)2.7 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (d )]TJ 0 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (as)8.9 ( s)8.9 (m)-6 (al)2.7 (l)2.6 (er)-5.9 ( t)-6.6 (han)10.5 ( )11.3 (20 m)-5.9 (i)2.6 (l)2.6 (l)2.6 (i)2.6 (m)-5.9 (et)-6.6 (er)4.9 (s)-2 (:)4.3 ( anal)2.6 (y)8.9 (s)-2 (i)2.6 (s)-2 ( o)10.5 (f)-17.5 ( 1060)10.5 ( )]TJ -0.005 Tc 0.01 Tw [(c)-5 (a)-3.3 (s)-5 (e)-3.4 (s)5.9 (.)-9.6 ( J)5.9 ( Clin)-3.4 ( )]TJ EMC ET endstream endobj 940 0 obj 27911 endobj %% Contents for page 107 %% Original object ID: 215 0 941 0 obj << /Length 942 0 R >> stream Q q BT /Xi105 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 942 0 obj 246 endobj %% Original object ID: 11550 0 943 0 obj [ 2751 0 R 2752 0 R 2753 0 R 2754 0 R 2755 0 R 2756 0 R 2757 0 R 2758 0 R 2759 0 R 2760 0 R 2761 0 R 2762 0 R 2763 0 R 2764 0 R ] endobj %% Contents for page 108 %% Original object ID: 216 0 944 0 obj << /Length 945 0 R >> stream q endstream endobj 945 0 obj 2 endobj %% Contents for page 108 %% Original object ID: 11551 0 946 0 obj << /Length 947 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (45)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2010;)-6.6 (9)10.5 (5:)-6.6 (4197)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.467 0 Td [(4205)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.467 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (20631031)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 499.2 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 477.6 Tm [(95.)-6.6 ( Li)2.7 (u R)13.5 (,)-6.6 ( B)1.9 (i)2.7 (s)-2 (hop )11.3 (J)-2 (,)4.2 ( Zhu )11.2 (G)-6.6 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( M)15.8 (or)-5.9 (t)-6.6 (al)2.6 (i)2.6 (t)-6.6 (y)8.9 ( R)2.6 (i)2.6 (s)-2 (k)-12.9 ( )0.5 (S)1.9 (t)4.3 (r)-6 (at)-6.7 (i)13.5 (f)-17.5 (i)2.7 (c)-2 (a)10.5 (t)-6.6 (i)2.6 (on by)8.9 ( C)2.6 (om)-6 (bi)2.6 (ni)2.6 (ng )]TJ -0.004 Tc 0.009 Tw 0 -1.141 Td [(BR)0.6 (AF)-1.7 ( V6)-2.3 (0)-2.4 (0)]TJ -0.002 Tc 0.007 Tw 5.261 0 Td [(E)2 ( and )11.3 (T)-10.6 (E)2 (R)13.4 (T)-10.5 ( )11.3 (P)1.9 (r)-5.9 (om)-5.9 (o)10.5 (t)-6.6 (er)4.9 ( M)15.8 (ut)-6.6 (at)-6.6 (i)2.6 (ons)-2 ( i)2.6 (n P)12.8 (api)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d C)2.6 (anc)-2 (er)-6 (:)-6.6 ( )]TJ -5.261 -1.152 Td [(G)-6.6 (enet)-6.6 (i)2.7 (c)8.8 ( D)2.6 (uet)-6.6 ( o)10.6 (f)-6.7 ( B)2 (R)2.6 (A)2 (F)11.1 ( a)10.6 (nd )11.2 (T)-10.5 (E)1.9 (R)2.6 (T P)2 (r)-6 (o)10.6 (m)-6 (ot)-6.7 (e)10.6 (r)-6 ( M)15.8 (ut)-6.6 (at)-6.6 (i)2.6 (ons)-2 ( i)2.6 (n )11.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d C)2.6 (anc)-2 (er)4.9 ( )]TJ 0 -1.141 Td [(M)15.8 (or)-5.9 (t)-6.6 (al)2.6 (i)2.7 (t)-6.7 (y)8.9 (.)-6.6 ( J)-2 (A)-8.9 (M)15.8 (A)1.9 ( O)-6.6 (nc)-2 (ol)2.6 ( 2)10.6 (016.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 0 -1.152 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (o)]TJ [(v)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (27581851)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.76 426.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 424.92 234.24 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 403.32 Tm [(96.)-6.6 ( V)1.9 (uon)10.5 (g H)2.6 (G)4.3 (,)-6.6 ( A)1.9 (l)2.7 (t)-6.7 (i)2.7 (bi)2.6 ( A)2 (M)4.9 (A)2 (,)-6.7 ( D)2.6 (uon)10.6 (g)-11.2 ( U)2.6 (N)2.6 (P)1.9 (,)4.3 ( H)2.6 (as)-2 (s)-2 (el)2.6 (l)2.6 ( )11.3 (L.)-6.6 ( P)2 (r)-6 (o)10.6 (g)-11.3 (no)10.5 (s)-2 (t)-6.6 (i)2.6 (c)-2 ( i)13.5 (m)-6 (pl)2.6 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (on )]TJ 0 -1.141 Td [(o)10.5 (f)-17.5 ( B)2 (R)2.6 (A)2 (F and)10.5 ( )11.3 (T)-10.6 (E)2 (R)2.6 (T pr)-5.9 (o)10.5 (m)-6 (ot)-6.6 (e)10.5 (r)-6 ( )11.3 (m)-5.9 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (on c)-2 (o)10.6 (m)-6 (bi)2.6 (nat)4.2 (i)2.6 (on i)2.7 (n papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0.002 Tw 0 -1.152 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)]TJ 0 Tc 0 Tw 4.598 0 Td (-)Tj -0.004 Tc -0.002 Tw 0.337 0 Td [(A m)-7.9 (e)-2.4 (t)-8.6 (a)]TJ 0 Tc 0 Tw 3.152 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(anal)2.6 (y)-2 (s)-2 (i)2.6 (s)-2 (.)-6.6 ( C)2.6 (l)2.6 (i)2.6 (n E)2 (ndoc)-2 (r)-6 (i)2.6 (nol)2.6 ( \()5 (O)-6.7 (x)19.8 (f)-17.5 (\))4.9 ( 2017;)-6.6 (87)10.5 (:)-6.6 (411)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 19.511 0 Td [(417)10.5 (.)-6.6 ( )]TJ 0.007 Tw -27.935 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)13.5 (w)2.6 (w)-8.3 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)4.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-6 (e)10.5 (d/)-6.6 (28666074)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 320.88 365.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 363.36 234.239 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 341.76 Tm [(97.)-6.6 ( S)1.9 (adow)13.5 ( P)1.9 (M)15.8 (,)-6.6 ( H)2.6 (ei)2.6 (nr)-5.9 (i)2.6 (c)-2 (h M)5 (C)2.6 (,)-6.6 ( C)2.6 (or)-5.9 (l)2.6 (es)-2 (s)-2 ( C)2.6 (L)10.6 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( A)12.8 (bs)-2 (enc)-2 (e o)10.5 (f)-6.6 ( B)2 (R)2.6 (A)2 (F,)4.2 ( N)2.6 (R)2.6 (A)2 (S)2 (,)-6.7 ( )]TJ 0 -1.141 Td [(K)2 (R)2.6 (A)1.9 (S)2 (,)-6.6 ( H)2.6 (R)2.6 (A)1.9 (S)2 ( m)-6 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (ons)-2 (,)4.3 ( and R)2.6 (E)12.9 (T)-10.6 (/)-6.6 (P)12.8 (T)-10.5 (C)2.6 ( )11.3 (gene )11.2 (r)-5.9 (ear)4.9 (r)-6 (an)10.5 (g)-11.2 (em)-5.9 (en)10.6 (t)-6.6 (s)-2 ( )]TJ 0 -1.152 Td [(di)2.6 (s)-2 (t)-6.6 (i)2.6 (ng)-11.2 (ui)2.6 (s)-2 (hes)8.8 ( dom)-5.9 (i)2.6 (nant)4.2 ( n)10.5 (odul)]TJ 12.848 0 Td [(es)-2 ( i)2.6 (n H)2.6 (as)-2 (hi)2.6 (m)-5.9 (ot)-6.6 (o)10.6 ( t)-6.7 (hy)8.9 (r)4.9 (oi)2.7 (di)2.6 (t)-6.6 (i)2.6 (s)-2 ( )11.3 (f)-17.5 (r)-6 (o)10.6 (m)-6 ( papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( )]TJ -12.848 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (as)-1.9 (.)4.2 ( E)2 (nd)10.6 (oc)-2 (r)-6 ( P)2 (a)10.5 (t)-6.6 (hol)2.6 ( 2010;)-6.6 (21)10.5 (:)-6.6 (73)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 20.783 0 Td [(7)10.5 (9.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -20.783 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (20012784)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 291.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 289.08 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 267.48 Tm [(98.)-6.6 ( R)2.6 (odr)-5.9 (i)13.4 (g)-11.2 (ues)8.9 ( H)2.6 (G)4.3 (,)-6.6 ( A)2 (A)12.8 ( D)2.6 (E)2 (P)2 (,)-6.7 ( )0.5 (A)1.9 (dan LF)11.2 (.)-6.6 ( C)2.6 (on)10.6 (t)-6.6 (r)-6 (i)2.6 (but)-6.6 (i)]TJ 21.337 0 Td [(o)10.5 (n o)10.5 (f)-6.6 ( t)-6.6 (he)10.6 ( B)1.9 (R)2.6 (A)2 (F onc)-2 (o)10.5 (g)-11.2 (ene)10.5 ( )]TJ -21.337 -1.141 Td [(i)2.6 (n t)-6.6 (he p)10.5 (r)-6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 4.5 0 Td [(ope)10.5 (r)-5.9 (at)-6.6 (i)2.6 (v)8.9 (e phas)8.9 (e o)10.6 (f)-6.7 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.6 (.)-6.6 ( )11.2 (O)-6.6 (nc)-2 (ol)2.6 ( Le)10.5 (t)-6.6 (t)4.3 ( 2013;)-6.6 (6)10.5 (:)-6.6 (191)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw -4.5 -1.152 Td [(196.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.2 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)-6.6 (g)-11.2 (ov)8.9 (/)-6.6 (pu)10.5 (bm)-5.9 (ed/)-6.6 (23946802)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 339.72 242.16 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 111.12 240.12 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 218.52 Tm [(99.)-6.6 ( C)2.6 (anadas)]TJ 0 Tc 0 Tw 5.652 0 Td (-)Tj 0.004 Tc 0.001 Tw 0.337 0 Td [(G)-0.6 (a)16.5 (rre)16.5 ( M)21.8 (,)-0.6 ( B)7.9 (e)5.7 (c)4 (e)5.6 (rra)]TJ 0 Tc 0 Tw 7.696 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(M)15.8 (as)-2 (s)-2 (ar)-6 (e )]TJ 0.007 Tw 4.098 0 Td [(P)2 (,)4.2 ( Lope)10.5 (z)8.9 ( de l)2.6 (a T)-10.5 (o)10.5 (r)-6 (r)-5.9 (e)]TJ 0 Tc 0 Tw 9.022 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(C)2.6 (as)-2 (ar)-5.9 (e)10.5 (s)-2 ( M)15.8 (,)-6.7 ( )]TJ -27.478 -1.141 Td [(et)-6.7 ( al)2.6 (.)4.3 ( R)2.6 (educ)-2 (t)-6.6 (i)2.6 (on)10.5 ( o)10.5 (f)-6.6 ( )11.3 (f)-17.5 (al)2.6 (s)-2 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 10.75 0 Td [(neg)-11.2 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d)-11.2 ( c)-2 (ar)-5.9 (c)-2 (i)2.6 (no)10.5 (m)-6 (as)-2 ( by)8.9 ( )11.3 (t)-6.6 (he )]TJ -10.75 -1.141 Td [(r)-6 (out)-6.6 (i)2.7 (ne anal)2.6 (y)8.9 (s)-2 (i)2.6 (s)-2 ( o)10.5 (f)-6.6 ( B)2 (R)2.6 (A)1.9 (F\()-5.9 (T)-10.6 (1)10.6 (799A)2 (\))-6 ( )11.3 (m)-6 (u)10.5 (t)-6.6 (at)-6.6 (i)2.6 (on on)10.6 ( )11.2 (f)-17.4 (i)2.6 (n)10.5 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 22.826 0 Td [(needl)2.6 (e as)-2 (pi)2.6 (r)-6 (a)10.6 (t)-6.6 (i)2.6 (on )]TJ -22.826 -1.152 Td [(bi)2.6 (ops)-2 (y)8.8 ( s)-2 (pec)-1.9 (i)2.6 (m)-6 (ens)-2 (:)-6.6 ( a)10.5 ( pr)-6 (o)10.5 (s)-2 (pec)-2 (t)-6.6 (i)2.6 (v)8.9 (e s)-2 (t)-6.6 (udy)8.8 ( o)10.6 (f)-6.7 ( 814 )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )0.5 (FN)2.7 (A)1.9 (B)2 ( pat)-6.6 (i)2.6 (ent)4.2 (s)-2 (.)4.3 ( A)2 (nn )]TJ 0 -1.141 Td [(S)2 (ur)-5.9 (g 2012;)-6.6 (2)10.5 (55)]TJ 0.002 Tw [(:)-6.6 (986)]TJ 0 Tc 0 Tw 8.478 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(992.)4.2 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -8.815 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22504197)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 155.28 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 153.24 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 131.64 Tm [(100.)-6.7 ( Lee)10.6 ( S)12.8 (T)-10.6 (,)4.3 ( K)2 (i)2.6 (m)-6 ( S)34.6 (W)-36.3 (,)4.3 ( K)1.9 (i)13.5 ( C)2.6 (S)2 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( )0.5 (i)2.6 (m)-6 (pl)2.7 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (on o)10.5 (f)-6.5 ( hi)2.6 (g)-11.2 (hl)2.6 (y)8.9 ( s)-2 (ens)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (e )]TJ 0 -1.141 Td [(det)-6.6 (ec)-1.9 (t)-6.7 (i)2.7 (on o)10.5 (f)-6.6 ( )11.2 (t)-6.6 (he)10.5 ( B)2 (R)2.6 (A)1.9 (F V)12.9 (600E)2 ( m)-6 (u)10.5 (t)-6.6 (at)-6.6 (i)2.6 (on i)2.6 (n)10.5 ( )11.3 (f)-17.5 (i)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 20.391 0 Td [(ne)10.5 (edl)2.6 (e)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc -0.004 Tw 3.261 0 Td [(as)-2 (pi)2.6 (r)-5.9 (at)-6.6 (i)2.6 (ons)-2 ( )-10.6 (o)10.5 (f)-6.6 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ 0.007 Tw -23.652 -1.152 Td [(nodul)2.6 (es)-2 (:)-6.6 ( a )11.3 (c)-2 (om)-5.9 (pa)10.6 (r)-6 (at)-6.7 (i)2.7 (v)8.8 (e )11.2 (anal)2.6 (y)8.9 (s)-2 (i)2.6 (s)-2 ( of)-17.5 ( )11.2 (t)-6.6 (hr)-6 (ee)10.5 ( )11.3 (m)-6 (ol)2.6 (ec)-2 (ul)2.6 (ar)-6 ( as)-2 (s)-2 (ay)8.9 (s)-2 ( i)2.6 (n 4585)10.5 ( )]TJ 0 -1.141 Td [(c)-2 (ons)-2 (ec)-2 (ut)-6.6 (i)2.6 (v)8.9 (e c)-2 (as)-2 (es)-2 ( )0.5 (i)2.6 (n)10.5 ( a B)12.9 (R)2.6 (A)1.9 (F V)2 (600E)2 ( m)-6 (u)10.6 (t)-6.7 (at)-6.6 (i)2.6 (on)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 20.674 0 Td [(p)10.5 (r)4.9 (ev)8.9 (al)2.6 (ent)-6.6 ( ar)-6 (ea.)-6.6 ( )11.3 (J)-2 ( C)2.6 (l)2.6 (i)2.6 (n )]TJ -20.674 -1.141 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2012;)-6.6 (9)10.5 (7:)-6.6 (2299)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.467 0 Td [(2306)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.467 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22500044)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 68.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 66.36 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(101.)-6.7 ( K)2 (l)2.6 (ei)2.6 (m)-6 (an D)2.6 (A)12.9 (,)-6.6 ( S)2 (po)10.5 (r)-6 (n )11.3 (M)15.7 (J)-2 (,)-6.6 ( B)2 (eni)2.6 (nat)-6.6 (o T,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( P)12.8 (r)4.9 (eoper)-5.9 (at)-6.6 (i)2.6 (v)8.9 (e B)2 (R)2.6 (A)2 (F\()-6 (V)2 (600E)2 (\))-6 ( )]TJ 0 -1.152 Td [(m)-6 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (on s)-2 (c)8.9 (r)-6 (eeni)2.6 (ng i)2.6 (s)-2 ( unl)13.5 (i)2.6 (k)-12.9 (el)2.6 (y)8.9 ( t)-6.6 (o al)2.6 (t)-6.6 (e)10.5 (r)-6 ( i)2.6 (ni)2.6 (t)-6.6 (i)2.6 (al)2.6 ( s)-2 (u)10.5 (r)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.7 ( t)-6.7 (r)-5.9 (ea)10.6 (t)-6.6 (m)-6 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (pat)-6.7 (i)2.7 (ent)-6.6 (s)8.8 ( )]TJ 0 -1.141 Td [(w)2.6 (i)2.6 (t)-6.6 (h i)2.6 (ndet)-6.6 (er)4.9 (m)-6 (i)2.6 (nat)-6.6 (e)10.6 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d nodul)2.7 (es)-2 (:)-6.6 ( a)10.5 ( p)10.5 (r)-5.9 (os)-2 (pec)-2 (t)-6.6 (i)2.6 (v)8.9 (e )11.2 (c)]TJ 22.38 0 Td [(as)-2 (e s)-2 (e)10.5 (r)-5.9 (i)2.6 (es)-2 ( o)10.6 (f)-6.7 ( 960)10.6 ( )]TJ -22.38 -1.152 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 (.)4.3 ( C)2.6 (anc)-2 (er)5 ( 2013)10.5 (;)-6.6 (1)10.5 (19:)-6.7 (1495)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.522 0 Td [(1502)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.522 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (23280049)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 463.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 461.28 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 439.68 Tm [(102.)-6.7 ( M)15.8 (c)-2 (I)-6.6 (v)8.9 (er)-5.9 ( B)1.9 (,)4.3 ( C)2.6 (as)-2 (t)4.2 (r)-5.9 (o M)15.8 (R)2.6 (,)-6.6 ( M)15.8 (or)-5.9 (r)-6 (i)2.6 (s)-2 ( J)-2 (C)2.7 (,)4.2 ( et)4.2 ( al)2.6 (.)4.2 ( A)2 (n i)2.7 (n)10.5 (dependent)-6.6 ( s)8.9 (t)-6.6 (udy)8.8 ( o)10.6 (f)-6.7 ( a )]TJ 0 -1.152 Td [(g)-11.2 (ene)10.5 ( ex)8.8 (pr)-6 (es)-2 (s)]TJ 5.989 0 Td [(i)2.6 (on c)-2 (l)2.6 (as)-2 (s)-2 (i)13.4 (f)-17.4 (i)13.5 (er)-5.9 ( \()-6 (A)12.8 (f)-6.6 (i)2.6 (r)4.9 (m)-5.9 (a\))4.9 ( )0.5 (i)2.6 (n t)-6.6 (he)10.5 ( ev)8.9 (al)2.6 (uat)-6.6 (i)2.6 (on o)10.5 (f)-17.5 ( c)-2 (y)8.9 (t)-6.6 (ol)2.6 (o)10.6 (g)-11.3 (i)2.7 (c)-2 (al)2.6 (l)2.6 (y)8.9 ( )]TJ -5.989 -1.141 Td [(i)2.6 (ndet)-6.6 (er)-5.9 (m)-6 (i)2.6 (na)10.5 (t)-6.6 (e )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d nodul)2.6 (es)-2 (.)-6.5 ( J)8.8 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( )11.3 (M)15.7 (et)-6.6 (ab 2014;)-6.6 (99:)-6.6 (4069)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 0 -1.141 Td [(4077.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.3 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.7 (nc)-2 (bi)2.6 (.)-6.7 (nl)2.6 (m)-5.9 (.)-6.7 (ni)2.6 (h.)-6.6 (g)-11.3 (ov)8.9 (/)-6.7 (pu)10.5 (bm)-6 (ed/)-6.6 (24780044)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 727.32 401.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 498.72 399.72 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 405 378 Tm (103.)Tj 0 Tc 0 Tw 1.946 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(K)2 (l)2.6 (oos)-2 ( R)13.4 (T,)-6.6 ( R)2.6 (ey)8.9 (nol)2.6 (ds)-2 ( J)-1.9 (D)2.5 (,)4.3 ( )22.1 (W)-36.2 (a)10.5 (l)2.6 (s)-2 (h P)1.9 (S)12.9 (,)-6.7 ( )0.5 (e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( D)2.6 (o)10.5 (es)-2 ( addi)2.6 (t)-6.6 (i)2.6 (on o)10.6 (f)-6.6 ( B)1.9 (R)2.6 (A)2 (F )]TJ -2.228 -1.141 Td [(V)2 (600E)2 ( m)-6 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (on )11.3 (t)-6.7 (es)-2 (t)-6.6 (i)2.6 (n)10.5 (g )11.2 (m)-5.9 (odi)13.5 (f)-17.5 (y)8.9 ( s)-2 (ens)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (i)2.6 (t)-6.6 (y)8.8 ( or)-6 ( s)-2 (pec)8.9 (i)2.6 (f)-17.5 (i)2.6 (c)-2 (i)2.7 (t)-6.7 (y)8.9 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.5 ( A)12.8 (f)-17.5 (i)2.6 (r)5 (m)-6 (a)10.5 ( G)-6.6 (ene)10.6 ( )]TJ 0 -1.141 Td [(E)2 (x)8.8 (pr)-6 (es)-2 (s)-2 (i)2.6 (on C)2.6 (l)2.6 (as)-2 (s)-2 (i)2.6 (f)-17.5 (i)2.6 (er)4.9 ( i)2.6 (n )11.3 (c)-2 (y)8.9 (t)-6.6 (ol)2.6 (og)-11.2 (i)2.6 (c)-2 (al)2.6 (l)2.6 (y)8.9 ( i)2.6 (ndet)-6.6 (er)-5.9 (m)-6 (i)2.6 (nat)-6.6 (e )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d nodul)2.6 (es)-2 (? J)8.8 ( C)2.6 (l)2.6 (i)2.7 (n )]TJ 0 -1.152 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2013;)-6.6 (9)10.6 (8:)-6.6 (E)1.9 (761)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.576 0 Td [(768.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)]TJ 4.359 0 Td [(abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -18.935 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (23476074)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 327.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 325.44 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 303.84 Tm [(104.)-6.7 ( )11.3 (T)-10.5 (heoha)10.5 (r)-6 (i)2.6 (s)-1.9 ( C)2.6 (,)4.3 ( R)2.6 (om)-6 (a)10.5 (n S)1.9 (,)-6.6 ( S)2 (os)8.8 (a J)-2 (A)12.8 (.)-6.6 ( )11.3 (T)-10.6 (he)10.6 ( m)-6 (ol)2.6 (ec)8.9 (ul)2.7 (ar)-5.9 ( di)2.6 (ag)-11.3 (no)10.5 (s)-2 (i)2.6 (s)-2 ( and )]TJ 0 -1.152 Td [(m)-6 (ana)10.6 (g)-11.2 (em)-5.9 (en)10.5 (t)-6.6 ( o)10.6 (f)-6.7 ( )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d n)10.5 (eopl)2.6 (as)-2 (m)-5.9 (s)-2 (.)4.2 ( C)2.6 (ur)-6 (r)5 ( )11.2 (O)-6.6 (pi)2.7 (n )11.3 (O)-6.6 (n)10.5 (c)-2 (ol)2.7 ( 2012;)-6.6 (24:)4.2 (35)]TJ 0 Tc 0 Tw (-)Tj -0.013 Tc 0.013 Tw 28.641 0 Td [(4)-11.3 (1.)-17.6 ( )]TJ -0.002 Tc 0.007 Tw -28.641 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (22123232)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 278.52 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 276.48 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 254.88 Tm [(105.)-6.7 ( H)2.7 (oda)10.5 (k)-2 ( S)1.9 (P)2 (,)-6.6 ( R)2.6 (os)-2 (en)10.5 (t)-6.6 (h)10.6 (al)2.6 ( D)2.6 (S)2 (,)-6.6 ( A)1.9 (m)-5.9 (e)10.5 (r)-6 (i)2.6 (c)-2 (an )11.3 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )11.3 (A)2 (s)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (i)2.6 (on C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( )]TJ 0 -1.152 Td [(A)2 (f)-6.7 (f)-6.6 (ai)2.6 (r)-5.9 (s)8.8 ( C)2.6 (.)4.3 ( I)-6.6 (n)10.5 (f)-6.6 (or)5 (m)-6 (at)-6.7 (i)2.7 (on)10.5 ( )11.3 (f)-17.5 (o)10.6 (r)-6 ( )11.3 (c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (i)2.6 (ans)-2 (:)-6.6 ( c)-2.1 (om)4.9 (m)-5.9 (er)-5.9 (c)-2 (i)2.6 (al)2.6 (l)2.6 (y)8.9 ( av)8.8 (ai)-8.3 (l)2.6 (abl)2.5 (e m)-5.9 (ol)2.6 (ec)-2 (ul)2.6 (ar)-6 ( )]TJ -0.004 Tw 0 -1.141 Td [(di)2.6 (ag)-11.2 (nos)-2 (i)2.6 (s)-2 ( t)-6.6 (e)]TJ 0.007 Tw [(s)-2 (t)-6.6 (i)2.6 (n)10.5 (g i)2.6 (n t)-6.7 (he)10.5 ( e)10.6 (v)8.8 (al)2.6 (uat)-6.6 (i)2.6 (on of)-6.7 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d nodul)13.5 (e )11.2 (f)-17.5 (i)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 24.826 0 Td [(needl)2.6 (e a)10.5 (s)-2 (pi)2.7 (r)-6 (at)-6.6 (i)2.5 (on )]TJ -0.004 Tw -24.826 -1.141 Td [(s)-2 (pec)-2 (i)2.6 (m)-5.9 (ens)-2 (.)4.2 ( T)-10.6 (hy)8.9 (r)-6 (oi)2.7 (d )-10.6 (201)10.5 (3;)-6.6 (23:)-6.6 (131)]TJ 0 Tc 0 Tw 14.457 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(134.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e )-10.5 (at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.793 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22984796)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 204.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 202.2 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.005 Tc 0.01 Tw 11.04 -0 0 11.04 405 180.6 Tm [(1)-3.3 (0)-3.4 (6)-3.3 (.)-9.7 ( Ce)-3.3 (lik)-5 ( B)-1.1 (,)1.3 ( )22.1 (W)-39.3 (h)7.5 (e)7.5 (t)-9.6 (s)-5 (e)-3.3 (ll C)10.4 (R,)-9.6 ( Na)-3.4 (s)-5 (s)-5 (a)-3.3 (r)1.9 ( A)-1.1 (.)]TJ 0 Tc 0 Tw 16.391 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)12.8 (f)-17.5 (i)2.7 (r)4.9 (m)-6 (a)10.5 ( G)-6.6 (E)12.8 (C)2.7 ( and t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d l)2.6 (es)-2 (i)2.7 (ons)-2 (:)4.2 ( A)2 (n)10.5 ( )]TJ -16.674 -1.141 Td [(i)2.6 (ns)-2 (t)-6.6 (i)2.6 (t)-6.6 (ut)-6.6 (i)2.6 (onal)2.6 ( ex)8.9 (per)-5.9 (i)2.6 (enc)-2 (e.)-6.6 ( )11.3 (D)2.6 (i)2.6 (ag)-11.3 (n C)2.6 (y)8.9 (t)-6.6 (opat)-6.6 (hol)2.6 ( 2015)10.5 (;)-6.6 (4)10.5 (3:)-6.6 (966)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 24.5 0 Td [(970)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -24.5 -1.152 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (26466552)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 639.24 155.28 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 153.24 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 131.64 Tm [(107.)-6.7 ( B)2 (r)-6 (aune)10.5 (r)-5.9 ( E)12.8 (,)-6.6 ( H)2.6 (ol)2.7 (m)4.9 (es)-2 ( )11.3 (B)1.9 (J)-2 (,)-6.6 ( )0.5 (K)1.9 (r)-5.9 (ane)10.5 ( J)-2 (F)11.2 (,)-6.7 ( e)10.6 (t)]TJ 0 Tc 0 Tw 18.065 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(al)2.6 (.)4.2 ( P)2 (er)5 (f)4.2 (or)-6 (m)-5.9 (anc)-2 (e)10.5 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.6 ( A)12.8 (f)-17.5 (i)13.5 (r)-6 (m)-5.9 (a)10.5 ( )]TJ -18.348 -1.141 Td [(G)-6.6 (ene E)2 (x)8.9 (pr)-5.9 (es)-2 (s)-2 (i)2.6 (on C)2.7 (l)2.6 (as)-2 (s)-2 (i)13.5 (f)-6.6 (i)2.6 (er)-6 ( i)2.6 (n )0.5 (H)2.6 (ur)4.9 (t)-6.6 (hl)2.6 (e C)2.6 (el)2.6 (l)2.6 ( T)-10.6 (hy)8.9 (r)-6 (oi)13.5 (d N)2.6 (odul)2.6 (es)-2 ( D)2.6 (i)13.5 (f)-6.6 (f)-17.5 (e)10.6 (r)-6 (s)-2 ( )11.3 (f)-6.6 (r)-6 (o)10.5 (m)4.9 ( )]TJ -0.004 Tw 0 -1.152 Td [(O)-6.6 (t)-6.6 (he)10.6 (r)-6 ( I)-6.6 (ndet)-6.6 (e)10.5 (r)-5.9 (m)-6 (i)2.6 (na)10.5 (t)-6.6 (e T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (N)2.6 (odul)2.6 (es)-2 (.)-6.6 ( T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )-10.7 (20)10.5 (15;)-6.6 (25:)-6.6 (789)]TJ 0 Tc 0 Tw 26.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(796.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e)-11.2 ( )]TJ -0.006 Tc 0.006 Tw -26.435 -1.141 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (ps)-2 (:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)]TJ 7.239 0 Td [(.)-6.6 (nl)2.6 (m)-6 (.)4.3 (ni)2.6 (h.)-6.6 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-6 (ed/)-6.6 (259629)10.5 (06)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 654.48 93.72 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 420.36 91.68 234.12 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 70.08 Tm [(108.)-6.7 ( D)2.7 (uh )11.2 (Q)4.3 (,)-6.6 ( A)1.9 (n)10.6 (g)-11.2 (el)2.6 (l)2.6 ( )11.3 (T)-10.6 (E)2 (,)4.2 ( )11.3 (B)2 (abi)2.6 (ar)-5.9 (z)8.9 ( J)-2 (,)-6.7 ( et)4.2 ( )0.5 (al)2.6 (.)4.3 ( D)2.6 (ev)8.9 (el)2.7 (op)-11.2 (m)-5.9 (ent)4.3 ( and v)8.8 (al)2.6 (i)2.6 (dat)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( )]TJ -0.004 Tw 0 -1.141 Td [(c)-2 (l)2.6 (as)-2 (s)-2 (i)2.6 (f)-17.5 (i)2.6 (er)4.9 (s)-2 ( t)-6.7 (o )-10.6 (enhanc)-2 (e)10.6 ( t)-6.6 (h)10.5 (e )-10.6 (A)12.8 (f)-17.5 (i)2.7 (r)4.9 (m)-6 (a g)-11.2 (eno)10.5 (m)-5.9 (i)2.6 (c)-2 ( )-10.6 (s)-2 (e)10.5 (q)-11.2 (ue)10.6 (nc)-2 (i)2.6 (ng)-11.2 ( c)-2.1 (l)2.7 (as)-2 (s)-2 (i)13.5 (f)-17.5 (i)2.6 (er)-6 ( )]TJ 0.007 Tw 0 -1.152 Td [(per)4.9 (f)-17.5 (o)10.6 (r)-6 (m)-5.9 (anc)-2 (e)10.5 ( a)10.5 (m)-5.9 (on)10.5 (g)-11.2 ( )11.3 ( H)2.6 5 (ht)-6.6 (l)2.6 (e c)-1.9 (el)2.6 (l)2.6 ( s)-2 (pec)-2 (i)2.6 (m)-5.9 (en)10.6 (s)-2 ( )11.2 ([)-6.6 (abs)-2 (t)4.3 (r)-6 (ac)-2 (t)4.3 (])-6.7 (.)4.3 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d 2017;)-6.6 (27)10.6 (;)-6.6 ( )]TJ EMC ET endstream endobj 947 0 obj 28595 endobj %% Contents for page 108 %% Original object ID: 217 0 948 0 obj << /Length 949 0 R >> stream Q q BT /Xi106 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 949 0 obj 246 endobj %% Original object ID: 11567 0 950 0 obj [ 2765 0 R 2766 0 R 2767 0 R 2768 0 R 2769 0 R 2770 0 R 2771 0 R 2772 0 R 2773 0 R 2774 0 R 2775 0 R 2776 0 R 2777 0 R 2778 0 R 2779 0 R ] endobj %% Contents for page 109 %% Original object ID: 218 0 951 0 obj << /Length 952 0 R >> stream q endstream endobj 952 0 obj 2 endobj %% Contents for page 109 %% Original object ID: 11568 0 953 0 obj << /Length 954 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (46)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(s)-2 (uppl)2.6 ( 1.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e a)]TJ -0.006 Tc 0.006 Tw [(t)-10.6 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 0 -1.152 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (l)2.6 (i)2.6 (eber)-6 (t)-6.6 (pub.)-6.6 (c)8.8 (om)-6 (/)-6.6 (doi)2.6 (/)-6.6 (pd)10.5 (f)-6.6 (/)-6.6 (10)10.6 (.)-6.6 (1089)10.6 (/)-6.7 (t)-6.6 (hy)8.9 (.)-6.7 (2)10.6 (017.)-6.6 (29050.)-6.6 (s)8.9 (c)-2 (.)-6.7 (abs)8.8 (t)-6.6 (r)-5.9 (ac)8.9 (t)-6.6 (s)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 375.12 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 499.2 351.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 477.6 Tm [(109.)-6.7 ( N)2.7 (i)13.4 (k)-12.8 (i)13.4 (f)-17.4 (or)-5.9 (ov)8.9 (a M)15.8 (N)2.6 (,)-6.6 ( M)15.8 (er)-6 (c)-2 (ur)-6 (i)2.6 (o S)1.9 (,)4.3 ( )22.1 (W)-36.2 (a)10.5 (l)2.6 (d A)12.9 (I)-6.6 (,)4.2 ( et)4.2 ( al)2.6 (.)4.3 ( A)1.9 (nal)2.6 (y)8.9 (t)-6.6 (i)2.6 (c)-2 (al)2.6 ( per)-6 (f)-17.5 (o)10.6 (r)-6 (m)4.9 (anc)-2 (e o)10.5 (f)-6.6 ( )]TJ 0 -1.141 Td [(t)-6.6 (he )11.3 (T)-10.6 (hy)8.9 (r)-5.9 (oS)2 (e)10.5 (q)-11.2 ( v)8.9 (3 )11.3 (g)-11.2 (eno)10.5 (m)-6 (i)2.6 (c)-2 ( c)-2 (l)2.6 (as)-2 (s)-2 (i)13.5 (f)-17.5 (i)2.6 (er)4.9 ( )11.3 (f)-17.5 (o)10.5 (r)-6 ( c)-2 (an)10.5 (c)-2 (er)4.9 ( di)2.6 (ag)-11.2 (nos)-2 (i)2.6 (s)8.9 ( i)2.6 (n t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d )]TJ 0 -1.152 Td [(nodul)2.6 (es)-2 (.)-6.6 ( C)2.6 (anc)-2 (er)5 ( 2018)10.5 (;)-6.6 (1)10.5 (24:)-6.7 (1682)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.522 0 Td [(1690)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -14.522 -1.141 Td [(h)6.7 (ttp)]TJ -0.002 Tc 0.002 Tw 1.674 0 Td [(s)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-6 (ed)10.6 (/)-6.6 (29345728)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.76 439.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 437.64 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 416.04 Tm [(110.)-6.7 ( D)2.7 (ui)2.6 (c)8.9 (k)-12.9 ( D)2.6 (S)12.8 (,)-6.5 ( K)1.9 (l)2.6 (opper)4.9 ( )11.3 (J)-2 (P)2 (,)-6.7 ( D)2.7 (i)13.4 (gg)-11.2 (ans)-2 ( J)-2 (C)13.5 (,)-6.6 ( e)10.5 (t)-6.6 ( al)13.5 (.)-6.6 ( )11.3 (T)-10.6 (h)10.5 (e i)2.6 (m)-6 (pac)8.9 (t)-6.6 ( o)10.5 (f)-6.6 ( beni)13.4 (g)-11.2 (n )11.2 (g)-11.2 (ene)10.5 ( )]TJ 0 -1.152 Td [(ex)8.8 (pr)-6 (es)-2 (s)-2 (i)2.6 (on c)-2 (l)2.6 (as)-2 (s)-2 (i)13.5 (f)-17.5 (i)2.7 (er)-5.9 ( )11.2 (t)-6.6 (es)-2 (t)4.2 ( r)-5.9 (es)-2 (ul)2.6 (t)4.3 (s)-2 ( on)10.5 ( t)-6.6 (he)10.5 ( endoc)-2 (r)-5.9 (i)2.6 (no)10.5 (l)2.6 (og)-11.2 (i)2.6 (s)-2 (t)]TJ 0 Tc 0 Tw 24.109 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(pa)10.5 (t)-6.6 (i)2.6 (ent)4.2 ( dec)-2 (i)2.7 (s)-2 (i)2.6 (on t)-6.6 (o)10.5 ( )]TJ -24.446 -1.141 Td [(oper)-6 (at)-6.7 (e)10.6 ( on pa)10.6 (t)-6.7 (i)2.7 (ent)-6.7 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d nodul)2.6 (es)-2 ( w)13.5 (i)2.6 (t)-6.6 (h i)2.6 (ndet)-6.6 (er)5 (m)-6 (i)2.6 (nat)-6.6 (e )11.2 (f)-6.6 (i)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 28.207 0 Td [(needl)2.6 (e )]TJ 0.007 Tw -28.207 -1.152 Td [(as)-2 (pi)2.6 (r)-5.9 (at)-6.6 (i)2.6 (on c)-2 (y)8.9 (t)-6.6 (opat)-6.6 (h)10.6 (ol)2.6 (og)-11.2 (y)8.8 (.)4.3 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d 2012;)-6.6 (22)10.6 (:)-6.6 (996)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 20.783 0 Td [(10)10.5 (01.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -20.783 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22873825)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 365.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 363.36 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 341.76 Tm [(111.)-6.7 ( A)2 (l)2.6 (ex)8.8 (ander)-5.9 ( E)2 (K)1.9 (,)4.3 ( S)1.9 (c)-2 (h)10.5 (or)-6 (r)-5.9 ( M)15.8 (,)-6.6 ( K)1.9 (l)2.6 (opper)5 ( J)-2.1 (,)4.3 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( )0.5 (M)4.9 (ul)2.6 (t)-6.6 (i)2.6 (c)-2 (ent)-6.6 (er)4.9 ( c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( )]TJ 0.002 Tw 0 -1.141 Td [(ex)8.8 (per)-5.9 (i)2.6 (enc)]TJ 0.007 Tw 4.315 0 Td [(e w)2.6 (i)2.6 (t)-6.6 (h t)-6.6 (he)10.5 ( A)12.8 (f)-17.5 (i)2.6 (r)5 (m)-6 (a )11.3 (g)-11.2 (ene)10.5 ( ex)8.9 (pr)-5.9 (es)-2 (s)-2 (i)2.6 (on c)-2 (l)2.6 (as)8.8 (s)-1.9 (i)2.6 (f)-17.5 (i)2.6 (er)4.9 (.)4.2 ( J)-2 ( C)2.6 (l)2.6 (i)2.7 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( )]TJ -4.315 -1.152 Td [(M)15.8 (et)-6.6 (ab 2014;)-6.6 (99:)-6.6 (119)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 8.935 0 Td [(125)10.5 (.)4.3 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (ab)-11.2 (l)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -8.935 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24152684)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 303.84 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 301.8 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 280.2 Tm [(112.)-6.7 ( )33.1 (W)-36.3 (a)10.5 (n)10.5 (g)-11.2 ( C)2.6 (C)2.6 (,)4.3 ( Fr)-6 (i)2.7 (ed)10.5 (m)-5.9 (a)10.5 (n L,)4.3 ( K)1.9 (ennedy)8.9 ( G)-6.7 (C)2.7 (,)4.2 ( et)4.2 ( al)2.6 (.)4.3 ( )11.2 (A)2 ( l)2.6 (ar)]TJ -0.004 Tw 23.413 0 Td [(g)-11.2 (e m)-6 (ul)2.6 (t)-6.6 (i)2.6 (c)-2 (ent)-6.6 (e)10.5 (r)-5.9 ( )]TJ 0.007 Tw -23.413 -1.152 Td [(c)-2 (or)-6 (r)-6 (el)2.6 (at)-6.7 (i)2.7 (on)10.5 ( s)-2 (t)-6.6 (udy)8.9 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d nodul)2.6 (e c)-2 (y)8.9 (t)-6.6 (opat)-6.7 (hol)2.7 (o)10.5 (g)-11.2 (y)8.8 ( and hi)2.6 (s)-2 (t)-6.7 (opat)4.3 (hol)2.6 (og)-11.2 (y)8.9 (.)-6.6 ( )]TJ 0 -1.141 Td [(T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d 2011;)-6.6 (21)10.5 (:)-6.6 (243)]TJ 0 Tc 0 Tw 9.141 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(25)10.5 (1.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -9.478 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21190442)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 242.16 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 240.12 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 218.52 Tm [(113.)-6.7 ( A)2 (l)2.6 (bar)-5.9 (el)2.6 ( F)11.2 (,)-6.6 ( C)2.6 (on)10.6 (t)-6.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.013 Tc 0.013 Tw 9.761 0 Td [(D)-8.4 (ev)-2.1 (o)-11.3 (l)]TJ -0.002 Tc 0.007 Tw 2.533 0 Td [(x)8.9 ( B)1.9 (,)-6.6 ( O)-6.6 (l)2.6 (i)2.6 (v)8.9 (er)-5.9 ( C)2.6 (.)-6.6 ( F)11.2 (r)-6 (o)10.5 (m)-5.9 ( n)10.5 (odul)2.6 (e t)-6.6 (o di)13.5 (f)-6.6 (f)-6.6 (er)4.9 (ent)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( )]TJ -12.293 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a:)4.3 ( c)-2 (ont)4.3 (r)-6 (i)2.6 (but)-6.7 (i)2.6 (ons)-2 ( o)10.6 (f)-6.6 ( )11.2 (m)-5.9 (ol)2.6 (ec)-2 (ul)2.7 (ar)-5.9 ( anal)13.5 (y)8.9 (s)-2 (i)2.6 (s)-2 ( i)2.6 (n 2012.)-6.6 ( A)2 (nn )]TJ 0 -1.141 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( \()-6 (P)2 (ar)-5.9 (i)2.6 (s)-2 (\))4.9 ( 2012)10.5 (;)4.3 (73:)-6.7 (155)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.076 0 Td [(164)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.076 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (e)]TJ [(d/)-6.6 (22503804)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 180.6 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 178.56 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 156.96 Tm [(114.)-6.7 ( A)2 (s)-2 (a)10.5 ( S)2 (L,)4.3 ( B)2 (edar)-5.9 (d)10.5 ( Y)1.9 (C)2.6 (.)-6.6 ( Fi)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.696 0 Td [(needl)2.6 (e a)10.5 (s)-2 (pi)2.7 (r)-6 (at)-6.6 (i)2.6 (on )11.2 (c)-2 (y)8.9 (t)-6.6 (ol)2.6 (og)-11.2 (y)8.9 ( and )]TJ -13.696 -1.141 Td [(hi)2.6 (s)-2 (t)-6.6 (opat)-6.6 (hol)2.6 (o)10.5 (g)-11.2 (y)8.9 (.)-6.6 ( I)-6.6 (n)10.5 (:)-6.6 ( C)2.6 (l)2.6 (ar)4.9 (k)-2 ( )11.3 (O)-6.7 (H)2.6 (,)4.3 ( N)2.6 (og)-11.3 (u)10.6 (c)-2 (hi)2.6 ( S)2 (,)4.3 ( eds)-2 (.)4.2 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.7 (d C)2.6 (anc)-2 (er)4.9 (:)-6.6 ( D)2.6 (i)2.6 (a)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)-2 ( )]TJ 0 -1.152 Td [(and )11.2 (T)-10.5 (r)-6 (ea)10.5 (t)-6.6 (m)-6 (en)10.5 (t)-6.6 (.)4.2 ( S)2 (t)4.3 ( Loui)2.6 (s)-2 (:)4.3 ( Q)-6.6 (ual)2.6 (i)2.6 (t)-6.6 (y)8.9 ( M)15.8 (edi)2.6 (c)-2 (al)2.6 ( P)2 (ubl)2.6 (i)2.6 (s)-2 (h)-11.2 (i)-8.3 (ng;)-6.6 ( 2000)10.5 (:)-6.6 (105)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 27.935 0 Td [(126)10.5 (.)]TJ 0 Tc 0 Tw 1.924 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -29.859 -2.141 Td [(115.)-6.7 ( S)2 (ee)10.5 (t)-6.6 (hal)2.6 (a R)2.7 (R)2.6 (,)-6.6 ( A)2 (s)-2 (a)10.5 ( S)12.8 (L,)-6.6 ( B)1.9 (ul)2.6 (l)2.6 (oc)8.8 (k)-12.8 ( M)15.8 (J)-2 (,)-6.6 ( et)4.3 ( al)2.6 (.)4.3 ( )]TJ [(P)1.9 (r)-5.9 (o)10.5 (t)4.3 (oc)-2 (ol)2.6 ( )11.3 (f)-17.5 (or)4.9 ( )0.5 (t)-6.7 (he)10.5 ( E)2 (x)8.8 (am)-6 (i)2.6 (nat)-6.6 (i)2.6 (on )]TJ 0 -1.141 Td [(o)10.5 (f)-17.5 ( S)2 (pec)-2 (i)2.6 (m)-5.9 (en)10.5 (s)-2 ( F)11.2 (r)-5.9 (om)4.9 ( P)2 (at)-6.6 (i)13.5 (ent)-6.6 (s)-2 ( )33 (W)-36.3 (i)13.5 (t)-6.6 (h C)2.6 (a)10.5 (r)-5.9 (c)-2.1 (i)2.7 (nom)-6 (as)8.9 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.5 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d G)-6.6 (l)2.6 (and.)4.3 ( )]TJ 0 -1.152 Td [(P)2 (r)-6 (ot)-6.7 (oc)-2 (ol)2.6 ( w)13.4 (eb pos)-2 (t)-6.5 (i)2.6 (n)10.5 (g dat)4.3 (e:)-6.7 ( J)-2 (une)10.6 ( 2017:)4.2 ( C)2.6 (ol)2.6 (l)2.6 (eg)-11.3 (e)10.6 ( o)10.5 (f)-6.6 ( )11.3 (A)1.9 (m)-5.9 (er)-5.9 (i)2.6 (c)-2 (an P)1.9 (a)10.5 (t)-6.6 (hol)2.6 (og)-11.2 (i)2.6 (s)8.9 (t)-6.6 (s)-2 (;)4.2 ( )]TJ 0 -1.141 Td [(2017.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC ET /Link <>BDC BT /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw 11.04 -0 0 11.04 117.24 70.08 Tm [(h)17.5 (ttp)6.7 (s)15.8 (:)11.3 (//c)5 (a)6.7 (p)17.5 (.o)6.6 (b)6.7 (j)-1.3 (e)17.6 (c)5 (ts)15.9 (.)11.2 (fr)1.1 (b)6.6 (.i)9.6 (o)17.6 (/p)6.7 (r)1.1 (o)17.5 (to)17.5 (c)5 (o)6.7 (l)9.6 (s)5 (/c)5 (p)]TJ 0 Tc 0 Tw 16.163 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.326 0 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d)]TJ 0 Tc 0 Tw (-)Tj ET 117.24 68.04 218.759 0.84 re f BT -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 23.52 57.48 Tm [(17pr)-6 (ot)-6.7 (oc)-2 (ol)]TJ 0 Tc 0 Tw 4.663 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(4000)10.5 (.)-6.6 (pd)10.6 (f)]TJ ET EMC /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 121.44 57.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 55.44 97.92 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(116.)-6.7 ( B)2 (al)2.6 (oc)-2 (h Z)32.9 (W)-36.3 (,)4.3 ( )11.2 (Fl)2.6 (ei)2.6 (s)-2 (her)-5.9 ( S)1.9 (,)4.3 ( Li)2.6 (V)1.9 (ol)2.6 (s)-2 (i)2.6 ( V)1.9 (A)2 (,)-6.6 ( )11.3 (G)-6.7 (upt)-6.7 (a)10.6 ( P)12.8 (K)2 (.)-6.7 ( D)2.7 (i)2.6 (ag)-11.2 (no)10.6 (s)-2 (i)2.6 (s)-2 ( o)10.5 (f)-6.6 ( ")5.2 (f)-6.6 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( )]TJ 0 -1.152 Td [(neopl)2.6 (as)-2 (m)-6 (")-5.7 (:)4.3 ( a)10.5 ( )11.3 (g)-11.2 (r)-6 (ay)8.8 ( z)8.9 (one i)2.7 (n t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )11.3 (f)-17.5 (i)2.6 (ne)]TJ 0 Tc 0 Tw 16.641 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(needl)2.6 (e as)-2 (p)10.5 (i)2.7 (r)-6 (at)-6.6 (i)2.6 (on c)-2 (y)8.8 (t)-6.6 (ol)2.6 (og)-11.2 (y)8.9 (.)4.3 ( D)2.7 (i)2.6 (ag)-11.2 (n)10.5 ( )]TJ -16.978 -1.141 Td [(C)2.6 (y)8.9 (t)-6.6 (opat)-6.6 (hol)2.6 ( 2002;)-6.6 (26:)-6.7 (41)]TJ 0 Tc 0 Tw 10.033 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(4)10.5 (4.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -10.37 -1.152 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)]TJ -0.002 Tc 0.002 Tw 3.217 0 Td [(w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.7 (m)-6 (.)-6.6 (ni)2.7 (h.)4.3 (gov)8.9 (/)-6.7 (pubm)-6 (ed/)-6.6 (11782086)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 473.88 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 452.28 Tm [(117.)-6.7 ( B)2 (al)2.6 (oc)-2 (h Z)32.9 (W)-36.3 (,)4.3 ( )11.2 (S)2 (eet)-6.6 (hal)13.5 (a )0.5 (R)2.5 (R)2.7 (,)-6.6 ( Fa)10.5 (q)-11.2 (ui)2.6 (n )33 (W)-36.3 (C)13.5 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( )11.3 (N)2.6 (oni)2.6 (nv)8.9 (as)-12.9 (i)2.6 (v)8.9 (e f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d neopl)2.6 (as)-1.9 (m)-6 ( w)13.5 (i)2.6 (t)-6.6 (h pa)10.5 (pi)2.7 (l)2.6 (l)2.6 (ar)-5.9 (y)]TJ 0 Tc 0 Tw 13.609 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(l)-8.3 (i)2.6 (k)-12.8 (e nuc)-2 (l)2.6 (ear)4.9 ( )11.2 (f)-17.4 (ea)10.5 (t)-6.6 (ur)4.9 (es)-2.1 ( )0.5 (\()-6 (N)13.5 (I)-6.6 (F)11.1 (T)-10.5 (P)1.9 (\))-5.9 (:)4.2 ( A)2 ( c)-2 (han)10.5 (g)-11.2 (i)2.6 (n)10.5 (g )]TJ -13.946 -1.152 Td [(par)-6 (adi)2.6 (gm)-5.9 ( i)2.6 (n)10.5 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d s)-2 (u)10.5 (r)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( pat)-6.7 (hol)2.6 (o)10.5 (g)-11.2 (y)8.9 ( and i)2.6 (m)-5.9 (pl)2.6 (i)2.6 (c)8.9 (at)-6.7 (i)2.7 (ons)-2 ( )11.2 (f)-17.5 (o)10.6 (r)-6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0.002 Tw 0 -1.141 Td [(c)-2 (y)8.9 (t)-6.6 (opat)]TJ 0.007 Tw 3.217 0 Td [(hol)2.6 (og)-11.2 (y)8.8 (.)-6.6 ( C)2.6 (anc)-2 (e)10.5 (r)-5.9 ( C)13.5 (y)8.8 (t)-6.6 (opat)-6.6 (hol)2.6 ( 2016;)-6.6 (124)10.5 (:)-6.6 (616)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 18.446 0 Td [(620.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -21.663 -1.141 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (27203786)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 639.24 401.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 399.72 234.24 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 378 Tm [(118.)-6.7 ( Fa)10.5 (q)-11.2 (ui)2.6 (n )33 (W)-36.3 (C)13.5 (,)4.3 ( )22.1 (W)-36.3 (o)10.6 (n)10.5 (g )11.3 (LQ)-6.7 (,)4.3 ( A)12.8 (f)-6.6 (r)-5.9 (o)10.5 (g)-11.2 (heh A)2 (H)2.6 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( I)4.2 (m)-5.9 (pac)-2 (t)4.3 ( o)10.5 (f)-6.6 ( r)-6 (e)10.5 (c)-1.9 (l)2.6 (as)-2 (s)-2 (i)13.5 (f)-17.5 (y)8.9 (i)2.6 (ng)-11.2 ( )]TJ 0 -1.141 Td [(noni)2.6 (nv)8.9 (as)-2 (i)-8.2 (v)8.9 (e f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)]TJ 0 Tc 0 Tw 9.196 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(v)8.9 (ar)-5.9 (i)2.6 (ant)-6.6 ( o)10.5 (f)-6.6 ( papi)2.7 (l)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (d c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-5.9 (a o)10.5 (n )11.2 (t)-6.6 (he )11.3 (r)-6 (i)2.7 (s)8.8 (k)-12.8 ( o)10.5 (f)-6.6 ( )]TJ -9.478 -1.141 Td [(m)-6 (al)2.6 (i)2.6 (g)-11.2 (nanc)-2 (y)8.8 ( i)2.6 (n )11.2 (T)-10.5 (he)10.6 ( B)1.9 (et)-6.6 (he)10.6 (s)-2.1 (da S)2 (y)8.9 (s)-2 (t)-6.6 (em)4.9 ( )11.3 (f)-17.5 (o)10.6 (r)-6 ( R)2.6 (epor)4.9 (t)-6.6 (i)2.6 (n)10.5 (g )11.3 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d C)2.6 (y)8.9 (t)-6.6 (opat)-6.6 (hol)2.6 (og)-11.2 (y)8.9 (.)4.2 ( )]TJ 0 -1.152 Td [(C)2.6 (anc)-2 (er)-6 ( C)2.6 (y)8.9 (t)-6.6 (opat)-6.6 (hol)2.6 ( 2016)10.5 (;)4.3 (124:)-6.7 (181)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.967 0 Td [(187)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -14.967 -1.141 Td [(h)6.7 (ttp)6.7 (s)15.9 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)6.6 (l)]TJ -0.002 Tc 0.002 Tw 8.304 0 Td [(m)-6 (.)-6.6 (ni)2.6 (h.)4.2 (g)-11.2 (ov)8.8 (/)-6.6 (pubm)-6 (ed)10.5 (/)-6.6 (26457584)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 639.24 327.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 325.44 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 303.84 Tm [(119.)-6.7 ( H)2.7 (or)-5.9 (ne)10.5 ( M)15.8 (J)-2 (,)-6.6 ( C)2.6 (hhi)2.6 (eng )11.3 (D)2.6 (C)2.6 (,)-6.6 ( )11.2 (T)-10.5 (heohar)-5.9 (i)2.6 (s)8.9 ( C)2.6 (,)-6.6 ( e)10.5 (t)-6.6 ( al)13.5 (.)-6.6 ( )11.3 (Thy)8.9 (r)-6 (oi)2.6 (d f)-17.4 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( l)2.6 (es)-2 (i)2.6 (on o)10.5 (f)-6.6 ( )]TJ 0 -1.152 Td [(undet)-6.6 (er)4.9 (m)-6 (i)2.6 (ned s)-2 (i)13.5 (g)-11.3 (ni)13.5 (f)-17.5 (i)2.6 (c)-2 (anc)8.9 (e:)-6.6 ( E)2 (v)8.9 (al)2.6 (uat)-6.6 (i)2.6 (on o)10.6 (f)-6.7 ( )0.5 (t)-6.7 (he)10.5 ( r)-5.9 (i)2.6 (s)8.8 (k)-2 ( )11.3 (o)10.5 (f)-17.5 ( )11.3 (m)-5.9 (al)2.6 (i)2.6 (g)-11.2 (nanc)-2 (y)8.8 ( us)-2 (i)2.6 (n)10.5 (g)-11.2 ( )11.3 (t)-6.6 (he )]TJ -0.016 Tc 0.016 Tw 0 -1.141 Td [(t)-20.6 (wo)]TJ 0 Tc 0 Tw 1.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(t)-6.6 (i)2.6 (er)-6 ( s)-2 (ub)]TJ 0 Tc 0 Tw 3.272 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(c)-2 (l)2.6 (as)-2 (s)-2 (i)13.4 (f)-17.4 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (o)10.6 (n.)-6.6 ( D)2.6 (i)2.6 (a)10.5 (g)-11.2 (n C)2.6 (y)8.8 (t)-6.6 (opat)-6.6 (hol)2.6 ( 201)10.5 (2;)-6.6 (40:)-6.6 (410)]TJ 0 Tc 0 Tw 19.663 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(415.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e )]TJ -0.006 Tc 0.006 Tw -25.489 -1.141 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (22508675)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 648.96 265.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 420.36 263.88 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 242.16 Tm [(120.)-6.7 ( M)15.8 (os)-2 (es)-2 ( )22.2 (W)-25.4 (,)4.2 ( )33 (W)-36.2 (e)10.5 (n)10.5 (g)-11.2 ( J)8.9 (,)-6.6 ( )11.2 (S)2 (ans)-2 (ano I)4.2 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( )0.5 (M)15.7 (ol)2.6 (ec)-2 (ul)-8.3 (ar)-6 ( )11.3 (t)-6.6 (es)-1.9 (t)-6.7 (i)2.7 (n)10.5 (g)-11.2 ( )11.2 (f)-6.6 (or)4.9 ( s)-2 (o)10.5 (m)-5.9 (at)-6.6 (i)2.6 (c)8.9 ( )]TJ 0 -1.141 Td [(m)-6 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (ons)-2 ( i)2.6 (m)-5.9 (p)10.5 (r)-6 (ov)8.9 (es)-2 ( t)-6.6 (he)10.5 ( )11.2 (ac)-2 (c)-2 (ur)-6 (ac)-2 (y)8.9 ( o)10.6 (f)-6.7 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (d )11.3 (f)-17.5 (i)2.6 (ne)]TJ 0 Tc 0 Tw 20.826 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(needl)2.6 (e as)-2 (pi)2.6 (r)-6 (at)-6.6 (i)2.6 (on bi)2.6 (ops)-2 (y)8.8 (.)4.3 ( )]TJ -0.013 Tc 0.018 Tw -21.152 -1.141 Td [(W)-36.4 (or)-6.1 (l)-8.4 (d)-11.3 ( J)-2.1 ( S)]TJ -0.002 Tc 0.007 Tw 4.326 0 Td [(ur)4.9 (g 2010;)-6.6 (34)10.5 (:)-6.6 (25)10.6 (89)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 8.141 0 Td [(2594.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -12.467 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (20703476)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 204.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 202.2 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 180.6 Tm [(121.)-6.7 ( C)2.7 (er)4.9 (s)-2 (os)-2 (i)2.6 (m)-6 (o)10.6 ( E)1.9 (,)-6.6 ( )11.3 (G)-6.6 (ha)10.5 (r)-5.9 (i)2.6 (b H)2.6 (,)-6.6 ( S)2 (u)10.5 (m)-5.9 (an V)1.9 (J)8.9 (,)4.2 ( )0.5 (G)-6.7 (oel)2.7 (l)2.6 (ner)4.9 ( J)-2 (R)2.6 (.)4.3 ( ")-5.7 (S)1.9 (us)-2 (pi)2.6 (c)-2 (i)2.6 (ous)-2 (")5.1 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d )]TJ 0 -1.141 Td [(c)-2 (y)8.9 (t)-6.6 (ol)2.6 (og)-11.2 (i)2.6 (c)-2 ( )11.2 (f)-17.4 (i)2.6 (ndi)2.6 (n)10.5 (g)-11.2 (s)-2 (:)4.2 ( )0.5 (ou)10.5 (t)-6.6 (c)-2 (o)10.5 (m)-5.9 (e i)2.6 (n pa)10.6 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)]TJ -0.004 Tw 17.989 0 Td [(t)-6.6 (hout)-6.6 ( )-10.6 (i)2.7 (m)4.9 (m)-6 (edi)2.6 (at)-6.6 (e s)-2 (ur)5 (g)-11.3 (i)2.6 (c)-2 (al)2.6 ( )]TJ 0.007 Tw -17.989 -1.152 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 (.)4.3 ( M)15.8 (ay)8.9 (o C)2.7 (l)-8.3 (i)2.6 (n P)2 (r)-6 (oc)-2 ( 1993;)-6.6 (68)10.5 (:)-6.6 (343)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 17.685 0 Td [(348)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -17.685 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8455392)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 142.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 140.64 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 119.04 Tm [(122.)-6.7 ( M)15.8 (c)-2 (H)2.6 (enr)-5.9 (y)8.9 ( C)2.6 (R)2.6 (,)-6.6 ( )22.1 (W)-36.3 (a)10.6 (l)13.5 (f)-17.5 (i)13.5 (s)-2 (h P)2 (G)4.2 (,)-6.6 ( R)2.6 (os)-2 (en)10.6 ( I)-6.7 (B)12.9 (.)-6.6 ( N)2.6 (on)]TJ 0 Tc 0 Tw 20.489 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(di)2.6 (ag)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)-2 ( f)-17.4 (i)2.6 (ne)10.6 ( )-10.7 (needl)2.6 (e )]TJ 0.002 Tw -20.826 -1.152 Td [(as)-2 (pi)2.6 (r)]TJ 0.007 Tw 2.163 0 Td [(at)-6.7 (i)2.7 (on bi)2.6 (ops)-2 (y)8.9 (:)-6.6 ( a)10.5 ( di)2.6 (l)2.6 (em)-5.9 (m)-6 (a)10.5 ( i)2.6 (n )11.3 (m)-6 (ana)10.5 (g)-11.2 (em)-6 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( )22.1 (nodul)2.7 (ar)-5.9 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d di)2.6 (s)-2 (eas)-2 (e)10.5 (.)-6.6 ( )]TJ -2.163 -1.141 Td [(A)2 (m)-6 ( S)2 (ur)4.9 (g 1993;)4.2 (59:)-6.6 (415)]TJ 0 Tc 0 Tw 9.696 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(4)10.5 (19.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -10.033 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8323073)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 81.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 79.08 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 57.48 Tm [(123.)-6.7 ( B)2 (r)-6 (aue)10.6 (r)-6 ( V)2 (F)11.2 (,)-6.7 ( E)2 (de)10.6 (r)-6 ( P)12.9 (,)-6.7 ( )11.3 (M)4.9 (i)2.6 (ehl)2.6 (e K)2 (,)-6.7 ( et)-6.6 ( al)13.5 (.)-6.6 ( )11.3 (I)-6.6 (nt)-6.6 (e)10.5 (r)-5.9 (ob)]TJ -0.004 Tw [(s)-2 (e)10.5 (r)-6 (v)8.9 (er)-6 ( )-10.6 (v)8.9 (ar)-5.9 (i)2.6 (at)-6.6 (i)2.6 (on f)-17.5 (o)10.6 (r)-6 ( )]TJ 0.007 Tw 0 -1.152 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2 (ound de)10.5 (t)-6.6 (er)4.9 (m)-6 (i)2.6 (nat)-6.6 (i)2.6 (on)10.5 ( o)10.6 (f)-6.7 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d nodul)2.6 (e v)8.9 (ol)2.6 (um)4.9 (es)-2 (.)-6.6 ( )11.3 (T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ EMC ET endstream endobj 954 0 obj 28143 endobj %% Contents for page 109 %% Original object ID: 219 0 955 0 obj << /Length 956 0 R >> stream Q q BT /Xi107 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 956 0 obj 246 endobj %% Original object ID: 11585 0 957 0 obj [ 2780 0 R 2781 0 R 2782 0 R 2783 0 R 2784 0 R 2785 0 R 2786 0 R 2787 0 R 2788 0 R 2789 0 R 2790 0 R 2791 0 R 2792 0 R 2793 0 R ] endobj %% Contents for page 110 %% Original object ID: 220 0 958 0 obj << /Length 959 0 R >> stream q endstream endobj 959 0 obj 2 endobj %% Contents for page 110 %% Original object ID: 11586 0 960 0 obj << /Length 961 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (47)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(2005;)-6.6 (15:)-6.6 (1169)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1175.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.152 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (16279851)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.76 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 499.2 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 477.6 Tm [(124.)-6.7 ( N)2.7 (ew)13.5 (m)-6 (an K)2 (D)2.6 (,)4.3 ( B)1.9 (l)2.6 (ac)-2 (k)-2 ( )11.2 (T,)-6.7 ( )0.5 (H)2.6 (el)2.6 (l)2.6 (er)-6 ( )11.3 (G)-6.6 (,)4.2 ( )]TJ [(et)4.3 ( al)2.6 (.)4.3 ( D)2.6 (i)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-6 (e)10.6 (nt)-6.6 (i)2.6 (at)-6.6 (ed )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-5.9 (:)4.2 ( )]TJ 0 -1.141 Td [(det)-6.6 (er)5 (m)-6 (i)2.6 (nant)-6.6 (s)8.8 ( o)10.6 (f)-6.7 ( )0.5 (di)2.6 (s)-2 (eas)-2 (e )11.2 (pr)-6 (o)10.6 (g)-11.3 (r)-5.9 (es)-2 (s)-2 (i)2.7 (on)10.5 ( i)2.6 (n pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( )11.2 (<)6 (21 y)8.9 (ear)-5.9 (s)-2 ( o)10.5 (f)-6.6 ( a)10.5 (g)-11.2 (e)10.5 ( at)4.2 ( )]TJ 0 -1.152 Td [(di)2.6 (ag)-11.2 (nos)-2 (i)2.6 (s)-2 (:)4.3 ( a )11.3 (r)-6 (epor)4.9 (t)-6.6 ( )11.3 (f)-6.6 (r)-6 (o)10.5 (m)5 ( t)4.3 (he S)2 (ur)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( D)2.6 (i)2.6 (s)-2 (c)-2 (i)2.6 (pl)2.6 (i)2.6 (ne C)2.6 (om)-6 (m)-6 (i)2.7 (t)4.2 (t)-6.6 (ee)10.5 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.6 ( )]TJ 0 -1.141 Td [(C)2.6 (hi)2.6 (l)2.6 (dr)-5.9 (en')-6.7 (s)-2 ( C)2.7 (anc)-1.9 (er)4.9 ( G)4.3 (r)-6 (oup)10.6 (.)-6.7 ( A)2 (nn S)2 (u)10.5 (r)4.9 (g)-11.2 ( 1998)10.6 (;)-6.7 (227)10.5 (:)-6.6 (533)]TJ 0 Tc 0 Tw 22.011 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(541.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.348 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9563542)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 426.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 424.92 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 403.32 Tm [(125.)-6.7 ( R)2.7 (obi)2.6 (e D)2.6 (K)2 (,)4.2 ( D)2.7 (i)2.6 (nauer)-6 ( )11.3 (C)24.3 (W)-36.2 (,)4.2 ( )11.3 (T)-10.5 (u)10.5 (t)-6.6 (t)-6.7 (l)2.7 (e)10.5 ( R)2.6 (M)15.8 (,)-6.6 ( et)-6.6 ( al)2.6 (.)4.2 ( )11.3 (T)-10.6 (h)10.6 (e i)2.6 (m)-5.9 (pac)8.8 (t)-6.6 ( o)10.5 (f)-6.6 ( i)2.6 (ni)2.6 (t)-6.6 (i)2.6 (al)2.6 ( s)-2 (ur)4.9 (g)-11.2 (i)2.6 (c)-2 (a)10.6 (l)2.6 ( )]TJ 0 -1.141 Td [(m)-6 (ana)10.6 (g)-11.2 (em)-5.9 (en)10.5 (t)-6.6 ( on)10.5 ( ou)10.6 (t)-6.6 (c)-2 (om)4.9 (e i)2.6 (n y)8.9 (oung)-11.3 ( )0.5 (p)10.5 (at)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h di)2.6 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (anc)-2 (er)-6 (.)4.3 ( J)8.8 ( P)2 (edi)2.6 (at)-6.5 (r)4.9 ( S)1.9 (ur)4.9 (g 1)10.6 (998)]TJ 0.002 Tw [(;)-6.6 (33:)-6.6 (1134)]TJ 0 Tc 0 Tw 16.228 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1138;)4.3 ( di)2.6 (s)-2 (c)-2 (u)10.6 (s)-2 (s)-2 (i)2.6 (on 1139)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 10.25 0 Td [(1140)10.5 (.)-6.6 ( )]TJ 0.007 Tw -26.815 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (9694109)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 309.12 365.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 363.36 222.48 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 341.76 Tm [(126.)-6.7 ( Leenha)10.5 (r)-5.9 (dt)4.3 ( L,)4.3 ( E)2 (r)-6 (do)10.5 (gan M)15.8 (F,)-6.6 ( H)2.6 (eg)-11.2 (edus)8.9 ( L,)4.3 ( et)4.3 ( al)2.6 (.)4.2 ( 2013 E)1.9 (ur)-6 (op)10.6 (ean )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ -0.004 Tw 0 -1.141 Td [(as)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (i)2.6 (on g)-11.3 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( f)-17.5 (o)10.5 (r)-5.9 ( )-10.6 (c)-2 (e)10.5 (r)-6 (v)8.9 (i)]TJ 0.007 Tw 13.565 0 Td [(c)-2 (al)2.6 ( ul)2.6 (t)-6.6 (r)-5.9 (as)-2 (ound s)8.9 (c)-2 (a)10.5 (n and ul)2.6 (t)4.3 (r)-6 (as)-2.1 (ound)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 15.793 0 Td [(gui)2.6 (ded )]TJ 0.007 Tw -29.359 -1.152 Td [(t)-6.6 (ec)-2 (hni)2.6 (q)-11.2 (ue)10.5 (s)-2 ( i)2.6 (n )11.3 (t)-6.7 (he po)10.5 (s)-2 (t)-6.6 (op)10.5 (er)-5.9 (at)-6.6 (i)2.6 (v)8.9 (e m)-6 (ana)10.5 (g)-11.2 (e)10.6 (m)-6 (ent)4.3 ( o)10.5 (f)-6.6 ( p)10.5 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.141 Td [(c)-2 (anc)-2 (er)-6 (.)4.3 ( E)1.9 (ur)4.9 ( )11.2 (T)-10.5 (hy)8.9 (r)-5.9 (oi)2.6 (d J)-2 ( 20)10.5 (13;)-6.7 (2:)-6.6 (147)]TJ 0 Tc 0 Tw 14.739 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(159.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e )-10.5 (at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -15.076 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed)]TJ [(/)-6.6 (24847448)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 291.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 289.08 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 267.48 Tm [(127.)-6.7 ( R)2.7 (obens)-2 (h)10.5 (t)-6.6 (o)10.5 (k)-12.9 ( E)12.9 (,)-6.6 ( Fi)2.6 (s)-2 (h)10.5 ( S)1.9 (,)-6.6 ( B)2 (ac)-2 (h)10.5 ( A)1.9 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( S)2 (us)-2 (pi)2.6 (c)-2 (i)2.6 (ous)-2 ( c)-2 (er)-6 (v)8.9 (i)2.6 (c)-2 (al)2.6 ( l)2.6 (y)8.9 (m)-5.9 (ph )]TJ 0 -1.141 Td [(nodes)-2 ( det)-6.6 (ec)8.8 (t)-6.6 (ed)10.5 ( a)10.5 (f)-6.6 (t)-6.6 (er)4.9 ( t)-6.6 (hy)8.9 (r)4.9 (oi)2.7 (dec)-2 (t)-6.6 (om)-5.9 (y)8.8 ( )11.3 (f)-17.5 (o)10.6 (r)-6 ( papi)2.7 (l)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.6 (h)10.6 (y)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)-5.9 ( us)-2 (ual)2.7 (l)2.6 (y)8.8 ( )]TJ 0 -1.152 Td [(r)-6 (em)-6 (ai)2.6 (n s)8.8 (t)-6.6 (abl)2.6 (e ov)8.9 (er)-6 ( y)8.9 (ear)-6 (s)8.9 ( i)2.6 (n pr)-5.9 (ope)10.5 (r)-6 (l)2.6 (y)8.9 ( s)-2 (el)2.6 (ec)-2 (t)-6.6 (ed pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 (.)4.2 ( )0.5 (J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)2 (ndoc)8.9 (r)-6 (i)2.7 (nol)2.6 ( )]TJ 0 -1.141 Td [(M)15.8 (et)-6.6 (ab 2012;)-6.6 (97:)-6.6 (2706)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.489 0 Td [(27)10.5 (13.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (a)]TJ [(bl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -9.489 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22639292)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 216.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 214.92 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 193.32 Tm [(128.)-6.7 ( R)2.7 (ondeau)10.6 ( G)4.3 (,)-6.6 ( Fi)2.6 (s)-2 (h)10.5 ( S)2 (,)4.3 ( H)2.7 (ann LE)1.9 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( U)2.6 (l)2.6 (t)-6.6 (r)-5.9 (as)-2 (on)10.5 (ogr)-6 (aphi)2.6 (c)-2 (al)2.6 (l)2.6 (y)8.9 ( det)-6.6 (ec)-2 (t)-6.6 (ed )]TJ 0 -1.152 Td [(s)-2 (m)-6 (al)2.6 (l)2.6 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d bed)10.5 ( nodul)2.6 (es)-2 ( i)2.6 (dent)-6.7 (i)13.5 (f)-17.5 (i)2.7 (ed a)10.5 (f)-6.6 (t)-6.6 (e)10.5 (r)-6 ( )11.3 (t)-6.6 (ot)-6.6 (al)13.5 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (dec)-2 (t)-6.6 (om)-5.9 (y)8.9 ( )11.2 (f)-6.6 (or)4.9 ( )]TJ 0.002 Tw 0 -1.141 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)]TJ 0.007 Tw 2.228 0 Td [(en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (an)10.6 (c)-2.1 (er)-6 ( s)-2 (el)2.6 (do)10.5 (m)-6 ( s)-2 (how)13.5 ( c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.7 (l)-8.3 (y)8.9 ( s)-2 (i)2.6 (g)-11.2 (ni)13.5 (f)-17.5 (i)2.6 (c)-2 (ant)4.3 ( s)-2 (t)4.3 (r)-6 (uc)-2 (t)-6.6 (u)10.6 (r)-6 (al)2.6 ( )]TJ -0.004 Tw -2.228 -1.152 Td [(pr)-6 (o)10.5 (g)-11.2 (r)-5.9 (es)-2 (s)-2 (i)2.6 (on)10.5 (.)-6.6 ( T)-10.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )-10.6 (201)10.5 (1;)-6.6 (21:)-6.7 (845)]TJ 0 Tc 0 Tw 14.902 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(853.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e )-10.5 (at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -15.239 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21809914)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 142.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 140.64 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 119.04 Tm [(129.)-6.7 ( )11.3 (G)-6.6 (i)2.6 (l)2.6 (l)2.6 (i)2.6 (l)2.7 (and FD)2.6 (,)-6.6 ( H)2.6 (unt)-6.6 ( )11.3 (W)-25.4 (C)13.5 (,)4.2 ( M)]TJ -0.005 Tc 0.01 Tw 13.348 0 Td [(o)-3.3 (r)-9 (r)-9 (is)-5 ( DM)12.8 (,)-9.6 ( K)-1.1 (e)-3.3 (y)5.8 ( CR.)-9.6 ( P)-1.1 (r)-8.9 (o)7.5 (g)-14.2 (n)-3.4 (o)-3.3 (s)5.8 (t)-9.6 (ic)-5 ( )11.3 (f)-20.5 (a)7.5 (c)-5 (t)-9.6 (o)7.5 (r)-9 (s)-5 ( )11.3 (f)-9.6 (o)-3.4 (r)1.9 ( )]TJ -0.002 Tc 0.007 Tw -13.348 -1.152 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a.)4.3 ( A)2 ( pop)10.5 (ul)2.7 (at)-6.6 (i)2.6 (on)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.293 0 Td [(bas)-2 (ed s)8.9 (t)-6.6 (udy)8.9 ( o)10.5 (f)-6.6 ( 1)10.5 (5,)-6.6 (698 c)-2 (as)-2 (e)10.6 (s)-2 ( )11.2 (f)-6.6 (r)-5.9 (o)10.5 (m)-6 ( )11.3 (t)-6.6 (he )]TJ -14.293 -1.141 Td [(S)2 (ur)-5.9 (v)8.8 (ei)2.6 (l)-8.3 (l)2.6 (anc)-2 (e,)-6.6 ( E)1.9 (pi)2.6 (dem)-5.9 (i)2.6 (ol)2.6 (og)-11.2 (y)8.8 ( and E)1.9 (nd)10.5 ( R)2.6 (es)-2 (ul)2.7 (t)-6.7 (s)8.9 ( \()-5.9 (S)1.9 (E)12.8 (E)2 (R)2.6 (\))-6 ( )0.5 (pr)-6 (o)10.6 (gr)-5.9 (am)4.9 ( 1973)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 30.033 0 Td [(1991)10.5 (.)4.2 ( )]TJ 0.007 Tw -30.033 -1.141 Td [(C)2.6 (anc)-2 (er)-6 ( 1997)10.5 (;)-6.6 (79:)-6.6 (564)]TJ 0 Tc 0 Tw 9.033 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(573)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -9.37 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9028369)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 68.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 66.36 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(130.)-6.7 ( S)2 (her)4.9 (m)-5.9 (an)10.6 ( S)2 (I)4.3 (,)-6.6 ( B)2 (r)-6 (i)2.7 (e)10.5 (r)-6 (l)2.7 (ey)8.9 ( J)-2 (D)2.6 (,)-6.6 ( S)1.9 (per)-5.9 (l)2.6 (i)2.6 (ng M)15.8 (,)-6.6 ( et)4.3 ( al)2.6 (.)-6.6 ( P)12.9 (r)-6 (os)-2 (pec)-2 (t)-6.6 (i)2.6 (v)8.8 (e m)-6 (ul)13.5 (t)-6.6 (i)2.6 (c)-2 (ent)-6.6 (er)4.9 ( )]TJ 0 -1.152 Td [(s)-2 (t)-6.6 (udy)8.9 ( o)10.5 (f)-17.5 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.5 (r)-6 (c)-2 (i)2.6 (nom)5 (a t)4.3 (r)-6 (eat)4.3 (m)-6 (ent)4.3 (:)-6.6 ( i)2.6 (ni)2.6 (t)-6.6 (i)2.7 (al)2.6 ( anal)2.6 (y)8.9 (s)-2 (i)2.6 (s)-2 ( o)10.5 (f)-17.5 ( )11.3 (s)-2 (t)-6.6 (a)10.5 (g)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( and)10.5 ( )]TJ 0 -1.141 Td [(out)-6.6 (c)-2 (om)-6 (e)10.5 (.)-6.6 ( N)2.6 (a)10.6 (t)-6.7 (i)2.6 (onal)2.6 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.7 (d C)2.6 (anc)-2 (er)4.9 ( )11.3 (T)-10.6 (r)-6 (ea)10.5 (t)-6.6 (m)-6 (en)10.5 (t)-6.6 ( C)2.6 (oo)10.5 (per)]TJ 23.489 0 Td [(at)-6.7 (i)2.7 (v)8.8 (e S)1.9 (t)-6.6 (udy)8.9 ( R)2.6 (eg)-11.3 (i)2.7 (s)8.8 (t)-6.6 (r)-5.9 (y)8.8 ( )]TJ -23.489 -1.152 Td [(G)-6.6 (r)-6 (oup)10.6 (.)-6.6 ( C)2.6 (anc)-2 (e)10.5 (r)-6 ( 1998)10.5 (;)-6.6 (83:)4.3 (1012)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.25 0 Td [(1021.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -13.25 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9731906)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 463.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 461.28 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 439.68 Tm [(131.)-6.7 ( )11.3 (T)-10.5 (s)-2.1 (an)10.5 (g R)24.3 (W)-25.4 (,)4.3 ( B)12.8 (r)-5.9 (i)2.6 (er)-5.9 (l)2.6 (ey)-2.1 ( J)-2 (D)2.6 (,)4.3 ( S)2 (i)2.6 (m)-6 (ps)-2 (on )33 (W)-36.3 (J)8.9 (,)4.3 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( )11.3 (T)-10.6 (he)10.6 ( e)10.5 (f)-6.6 (f)-6.6 (ec)-2 (t)4.3 (s)-2 ( o)10.5 (f)-6.6 ( s)-2 (u)10.5 (r)4.9 (g)-11.2 (er)-6 (y)8.9 (,)-6.6 ( )]TJ 0 -1.152 Td [(r)-6 (adi)2.7 (oi)2.6 (odi)2.6 (ne,)-6.6 ( a)]TJ [(nd ex)8.9 (t)-6.6 (er)-6 (nal)13.5 ( r)-6 (adi)2.6 (at)-6.6 (i)2.6 (on )11.3 (t)-6.6 (her)-6 (apy)8.9 ( on)10.6 ( t)-6.6 (he)10.5 ( )11.3 (c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.7 ( out)-6.6 (c)-2 (om)-6 (e o)10.5 (f)-6.6 ( )]TJ 0 -1.141 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h di)13.5 (f)-6.6 (f)-6.6 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (e)10.5 (d )0.5 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( C)2.6 (an)10.5 (c)-1.9 (er)-5.9 ( 1998)10.5 (;)-6.6 (82:)-6.6 (375)]TJ 0 Tc 0 Tw 29.304 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(388.)4.2 ( )]TJ 0.007 Tw -29.641 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (9445196)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 690.6 401.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 399.72 222.48 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 378 Tm [(132.)-6.7 ( M)15.8 (az)-2 (z)8.8 (a)]TJ [(f)-17.5 (er)4.9 (r)-6 (i)2.7 ( E)1.9 (L.)4.2 ( M)15.8 (an)-11.3 (ag)-11.2 (e)10.5 (m)-5.9 (ent)4.2 ( o)10.5 (f)-6.6 ( a )11.2 (s)-2 (ol)2.6 (i)2.6 (t)-6.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )0.5 (nodul)2.6 (e.)-6.6 ( N)13.5 ( E)2 (n)10.5 (g)-11.3 (l)2.7 ( J)8.8 ( )]TJ 0 -1.141 Td [(M)15.8 (ed 1993;)-6.6 (328:)-6.5 (553)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 8.652 0 Td [(559.)4.2 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -8.652 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8426623)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 350.76 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 329.16 Tm [(133.)-6.7 ( D)2.7 (ot)4.3 (t)-6.6 (or)-5.9 (i)2.6 (ni)2.6 ( M)15.8 (E)2 (,)-6.6 ( V)1.9 (i)2.6 (g)-11.2 (na)10.5 (t)4.3 (i)2.6 ( A)2 (,)-6.6 ( M)15.8 (az)-1.9 (z)8.8 (uc)-2 (c)-2 (hel)2.6 (l)-8.3 (i)2.6 ( L,)-6.6 ( et)4.3 ( al)2.6 (.)4.3 ( D)2.6 (i)2.6 (f)-6.6 (f)]TJ 23.826 0 Td [(e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ -23.826 -1.152 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( i)2.6 (n c)-2 (hi)2.6 (l)2.6 (dr)-6 (en an)10.5 (d adol)2.6 (es)-2 (c)-2 (ent)-6.6 (s)8.8 (:)-6.6 ( a)10.5 ( 37)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 19.793 0 Td [(y)8.9 (ear)4.9 ( ex)8.9 (per)-5.9 (i)2.6 (enc)-2 (e i)2.7 (n 85 )]TJ -19.793 -1.141 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 (.)4.3 ( J)8.8 ( N)2.6 (uc)-2 (l)2.6 ( M)15.8 (ed 1997;)-6.6 (38:)-6.6 (669)]TJ 0 Tc 0 Tw 14.848 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(675.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e )-10.5 (at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -15.185 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9170425)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 291.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 289.08 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 267.48 Tm [(134.)-6.7 ( S)2 (a)10.5 (m)-5.9 (uel)2.6 ( A)1.9 (M)15.8 (,)-6.6 ( R)2.6 (aj)-8.3 (as)-2 (h)10.5 (ek)-12.8 (ha)10.6 (r)-6 (r)-6 (ao)10.5 ( B)2 (,)4.2 ( S)2 (hah D)2.6 (H)2.6 (.)4.2 ( P)12.9 (ul)2.6 (m)-5.9 (onar)-5.9 (y)8.8 ( m)-5.9 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (a)10.6 (s)-2 (es)-2 ( i)2.6 (n )]TJ 0 -1.141 Td [(c)-2 (hi)2.6 (l)2.6 (dr)-5.9 (en and adol)2.6 (es)-2 (c)-2 (en)10.5 (t)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h w)13.5 (e)-11.2 (l)2.6 (l)]TJ 0 Tc 0 Tw 15.054 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(di)2.6 (f)-6.6 (f)-17.5 (e)10.5 (r)-6 (ent)-6.6 (i)2.7 (a)10.5 (t)-6.6 (ed )11.2 (t)4.3 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)-6 (.)4.2 ( J)-2 ( N)2.6 (uc)-2 (l)13.5 ( )]TJ -15.391 -1.152 Td [(M)15.8 (ed 1998;)-6.6 (39:)-6.6 (1531)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 8.652 0 Td [(1536)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -8.652 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)6.6 (l)9.6 (m)1.1 (.)]TJ -0.002 Tc 0.002 Tw [(ni)2.6 (h.)4.3 (gov)8.9 (/)-6.7 (pubm)-6 (ed/)-6.6 (9744337)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 229.56 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 227.52 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 205.92 Tm [(135.)-6.7 ( S)2 (c)-2 (hl)2.6 (um)-5.9 (be)10.6 (r)4.9 (g)-11.3 (er)4.9 ( M)15.8 (,)-6.6 ( D)2.6 (e V)2 (at)-6.6 (hai)2.6 (r)-6 (e)10.5 ( F,)4.3 ( )11.3 (T)-10.6 (r)-6 (av)8.9 (ag)-11.2 (l)2.6 (i)2.6 ( J)-2 (P)12.8 (,)-6.6 ( e)10.6 (t)-6.7 ( al)2.6 (.)4.3 ( D)2.6 (i)13.4 (f)-6.6 (f)-17.4 (e)10.5 (r)-6 (ent)-6.6 (i)2.6 (a)10.6 (t)-6.7 (ed )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a )0.5 (i)2.6 (n c)-2 (hi)2.6 (l)13.5 (dhood:)-6.6 ( l)2.6 (on)10.5 (g)-11.2 ( )11.3 (t)-6.7 (er)4.9 (m)4.9 ( )11.3 (f)-17.5 (ol)2.6 (l)2.6 (ow)]TJ 0 Tc 0 Tw 20.978 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up o)10.5 (f)-6.6 ( 72 pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 (.)-6.6 ( J)8.8 ( C)2.6 (l)2.6 (i)2.6 (n )]TJ -21.315 -1.152 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 1987;)-6.6 (6)10.6 (5:)-6.6 (1088)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.467 0 Td [(1094)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.467 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (3680475)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 168 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 165.96 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 144.36 Tm [(136.)-6.7 ( H)2.7 (ay)8.9 ( I)-6.6 (D)2.6 (,)4.2 ( B)2 (er)5 (gs)-2 (t)4.3 (r)-6 (al)2.6 (h )11.2 (E)2 (J)-2 (,)-6.7 ( )11.3 (G)-6.6 (oel)2.6 (l)2.7 (ner)-6 ( J)-2 (R)13.5 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( P)1.9 (r)5 (edi)2.6 (c)-2 (t)-6.6 (i)2.6 (ng out)-6.6 (c)-2 (o)10.5 (m)-5.9 (e i)2.6 (n)10.5 ( )]TJ 0 -1.152 Td [(papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-6 (a:)4.2 ( dev)8.9 (el)2.6 (opm)-5.9 (ent)-6.6 ( o)10.5 (f)-6.6 ( a)10.5 ( r)-5.9 (el)13.5 (i)2.6 (abl)2.6 (e pr)-5.9 (og)-11.2 (no)10.5 (s)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (s)-2.1 (c)-2 (or)-6 (i)2.7 (n)10.5 (g)-11.2 ( )]TJ 0 -1.141 Td [(s)-2 (y)8.9 (s)-2 (t)-6.6 (em)-5.9 ( i)2.6 (n a)10.5 ( c)-2 (oho)10.6 (r)-6 (t)4.3 ( o)10.5 (f)-6.6 ( 17)10.6 (79 pat)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( s)-2 (u)10.6 (r)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 (l)]TJ 19.38 0 Td [(y)8.9 ( t)-6.6 (r)-6 (eat)-6.6 (ed a)10.5 (t)-6.6 ( one)10.6 ( i)2.6 (ns)-2 (t)-6.6 (i)2.6 (t)-6.6 (u)10.5 (t)-6.6 (i)2.6 (on )]TJ -19.38 -1.152 Td [(dur)-6 (i)2.7 (ng 1940 )11.2 (t)-6.6 (hr)-6 (ou)10.5 (g)-11.2 (h)10.5 ( 198)10.5 (9.)-6.6 ( S)1.9 (ur)4.9 (g)-11.2 (e)10.5 (r)-5.9 (y)8.8 ( 1993;)-6.6 (114)10.6 (:)-6.6 (105)10.5 (0)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 22.717 0 Td [(1057;)4.3 ( di)2.6 (s)-2 (c)-2 (us)-2 (s)-2 (i)2.6 (on )]TJ 0.002 Tw -22.717 -1.141 Td (1057)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 2.554 0 Td [(1058.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 8.467 0 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8256208)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 749.28 93.72 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 526.68 91.68 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 70.08 Tm [(137.)-6.7 ( S)2 (haha)10.5 ( A)1.9 (R)2.7 (,)-6.7 ( Lo)10.5 (r)-5.9 (ee )11.2 (TR)2.6 (,)-6.6 ( S)2 (hah J)-1.9 (P)12.8 (.)-6.6 ( )]TJ -0.004 Tw [(P)12.8 (r)-5.9 (o)10.5 (g)-11.3 (nos)-1.9 (t)-6.6 (i)2.5 (c)8.9 ( f)-6.6 (ac)-2 (t)-6.6 (or)-6 (s)8.9 ( )-10.6 (and r)-5.9 (i)2.6 (s)8.8 (k)-12.8 ( gr)-6 (oup )]TJ 0.007 Tw 0 -1.141 Td [(anal)2.6 (y)8.8 (s)-1.9 (i)2.6 (s)-2.1 ( i)2.7 (n f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( c)-2 (ar)4.9 (c)-2 (i)2.6 (nom)-5.9 (a o)10.6 (f)-6.6 ( )11.2 (t)-6.6 (he )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d.)-6.6 ( S)1.9 (u)10.5 (r)5 (g)-11.3 (e)10.6 (r)-6 (y)8.9 ( 1995;)-6.6 (118:)-6.6 (1131)]TJ 0 Tc 0 Tw 30.467 0 Td (-)Tj EMC ET endstream endobj 961 0 obj 27032 endobj %% Contents for page 110 %% Original object ID: 221 0 962 0 obj << /Length 963 0 R >> stream Q q BT /Xi108 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 963 0 obj 246 endobj %% Original object ID: 11602 0 964 0 obj [ 2794 0 R 2795 0 R 2796 0 R 2797 0 R 2798 0 R 2799 0 R 2800 0 R 2801 0 R 2802 0 R 2803 0 R 2804 0 R 2805 0 R 2806 0 R 2807 0 R 2808 0 R 2809 0 R ] endobj %% Contents for page 111 %% Original object ID: 222 0 965 0 obj << /Length 966 0 R >> stream q endstream endobj 966 0 obj 2 endobj %% Contents for page 111 %% Original object ID: 11603 0 967 0 obj << /Length 968 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (48)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(1136;)-6.6 ( di)2.7 (s)-2 (c)-2 (us)-2 (s)-2 (i)2.6 (on)10.5 ( 1136)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 10.261 0 Td [(1)10.5 (138.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -10.261 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (7491533)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 499.2 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 477.6 Tm [(138.)-6.7 ( C)2.7 (ady)8.8 ( B)2 (.)4.2 ( S)2 (t)-6.6 (a)10.5 (g)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( i)2.6 (n )11.3 (t)4.2 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( C)2.6 (anc)-2 (e)10.5 (r)-6 ( )0.5 (1998)10.5 (;)-6.6 (83:)-6.6 (844)]TJ 0 Tc 0 Tw 28.196 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(847.)4.2 ( )]TJ 0.007 Tw -28.533 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (9731884)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 309.12 465 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 462.96 222.48 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 441.36 Tm [(139.)-6.7 ( D)2.7 (e)10.5 (G)-6.6 (r)-6 (oo)10.5 (t)-6.6 ( LJ)8.9 (,)-6.6 ( K)1.9 (apl)2.6 (an)10.6 ( E)2 (L,)-6.7 ( S)12.9 (t)-6.6 (r)-6 (au)10.6 (s)-2 ( FH)2.6 (,)4.3 ( S)1.9 (hu)10.5 (k)-12.9 (l)2.6 (a )11.2 (M)5 (S)1.9 (.)-6.6 ( D)2.6 (oes)-2 ( )11.3 (t)-6.6 (he )11.3 (m)-6 (et)-6.6 (hod)10.5 ( o)10.5 (f)-6.6 ( )]TJ 0.002 Tw 0 -1.152 Td [(m)-6 (an)]TJ 0.007 Tw [(a)10.6 (g)-11.2 (em)-5.9 (en)10.5 (t)-6.6 ( o)10.6 (f)-6.7 ( )11.3 (papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.5 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( m)-5.9 (a)10.5 (k)-12.9 (e)10.5 ( a di)13.5 (f)-6.6 (f)-6.6 (er)-5.9 (enc)-2 (e)10.5 ( i)2.6 (n )]TJ 0 -1.141 Td [(out)-6.6 (c)-2 (om)-6 (e?)10.6 ( )22.1 (W)-36.3 (o)10.6 (r)4.9 (l)2.6 (d J)8.9 ( S)2 (ur)4.9 (g )11.3 (1994;)-6.6 (18:)-6.6 (123)]TJ 0 Tc 0 Tw 16.228 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(130.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -16.565 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8197768)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 403.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 401.28 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.005 Tc 0.01 Tw 11.04 -0 0 11.04 23.52 379.68 Tm [(1)-3.3 (4)-3.4 (0)-3.3 (.)-9.7 ( M)12.8 (ic)-5 (c)-5 (o)-3.4 (li P)-1 (,)-9.6 ( A)-1 (n)-3.4 (t)-9.6 (o)-3.3 (n)-3.4 (e)-3.3 (lli A)-1 (,)-9.6 ( S)-1.1 (p)-3.3 (in)-3.4 (e)-3.3 (lli C,)]TJ 0 Tc 0 Tw 16.565 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(et)4.2 ( al)2.6 (.)4.2 ( C)2.7 (om)-6 (p)10.6 (l)2.6 (et)-6.6 (i)2.6 (on t)-6.6 (ot)-6.6 (al)13.5 ( )]TJ -16.848 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( i)2.6 (n c)-2 (hi)2.6 (l)2.6 (dr)-6 (en)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 ( s)-2 (ec)-2 (o)10.6 (ndar)-5.9 (y)8.8 ( t)-6.6 (o )11.2 (t)-6.6 (he C)2.6 (he)10.5 (r)-5.9 (noby)8.9 (l)2.6 ( )]TJ 0 -1.152 Td [(ac)-2 (c)-2 (i)2.6 (dent)-6.6 (.)4.3 ( A)1.9 (r)-5.9 (c)-2 (h)10.5 ( S)2 (ur)4.9 (g 199)10.5 (8;)-6.7 (133:)-6.6 (89)]TJ 0 Tc 0 Tw 14.511 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(93.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.848 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9438766)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 341.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 339.72 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 23.52 318.12 Tm [(141.)-6.7 ( )]TJ 0.007 Tw 2.228 0 Td [(P)2 (al)2.6 (m)-5.9 (e)10.5 ( C)2.6 (E)1.9 (,)-6.6 ( )33.1 (W)-36.3 (a)10.5 (s)-2 (ee)10.5 (m)-6 ( Z)11.2 (,)-6.6 ( R)2.6 (az)8.8 (a S)1.9 (N)2.6 (,)-6.6 ( e)10.6 (t)4.2 ( al)2.6 (.)-6.6 ( M)15.8 (anag)-11.2 (e)10.5 (m)-5.9 (ent)4.2 ( and ou)10.6 (t)-6.7 (c)-2 (o)10.6 (m)-6 (e )11.2 (o)10.6 (f)-17.5 ( )]TJ -2.228 -1.141 Td [(r)-6 (ec)-2 (ur)5 (r)-6 (ent)4.3 ( w)13.5 (el)2.6 (l)]TJ 0 Tc 0 Tw 5.967 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(di)2.6 (f)-6.6 (f)-17.5 (er)-5.9 (en)10.6 (t)-6.7 (i)2.7 (at)4.3 (ed t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )0.5 (c)-2 (a)10.5 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( A)2 (r)4.9 (c)-2 (h O)4.3 (t)-6.6 (ol)2.6 (ar)-6 (y)8.9 (ng)-11.2 (ol)2.6 ( H)2.6 (ead)10.5 ( )]TJ -6.304 -1.152 Td [(N)2.6 (ec)-2 (k)-2 ( S)1.9 (ur)4.9 (g 2004;)-6.6 (130)10.6 (:)-6.6 (819)]TJ 0 Tc 0 Tw 11.022 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(824.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -11.359 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)6.6 (l)9.6 (m)1.1 (.n)]TJ -0.002 Tc 0.002 Tw 9.478 0 Td [(i)2.6 (h.)4.2 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (15262757)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 280.2 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 278.16 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 256.56 Tm [(142.)-6.7 ( F)11.2 (r)-5.9 (an)10.5 (k)-12.8 (ent)-6.6 (hal)2.6 (er)5 ( R)2.6 (A)1.9 (,)4.3 ( )11.2 (S)2 (el)2.6 (l)2.6 (i)2.6 (n R)2.6 (V)2 (,)-6.6 ( C)2.6 (ang)-11.2 (i)2.6 (r)4.9 ( A)2 (,)-6.6 ( )11.2 (G)-6.6 (oe)10.5 (p)10.5 (f)-17.5 (er)4.9 (t)-6.6 ( H)2.6 (.)4.3 ( Ly)8.9 (m)-6 (ph node)10.5 ( )]TJ -0.004 Tw 0 -1.152 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (i)2.6 (s)-2 ( f)-6.6 (r)-5.9 (o)10.5 (m)4.9 ( )-10.6 (papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)]TJ 0 Tc 0 Tw 11.022 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (no)10.5 (m)-6 (a i)2.6 (n y)8.8 (oun)10.6 (g)-11.3 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 (.)-6.6 ( )]TJ -11.348 -1.141 Td [(A)2 (m)-6 ( J)8.9 ( S)1.9 (ur)4.9 (g 1990;)-6.6 (160)10.6 (:)-6.6 (341)]TJ 0 Tc 0 Tw 11.022 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(343.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -11.359 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (2221231)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 218.52 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 216.48 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 194.88 Tm [(143.)-6.7 ( H)2.7 (e)10.5 (m)-6 (m)-5.9 (i)2.6 (n)10.5 (k)-12.9 (i)2.7 ( K)12.9 (,)-6.6 ( E)1.9 (n)10.5 (g)-11.2 ( C)13.5 (,)-6.6 ( C)2.6 (hen )0.5 (B)12.8 (.)-6.6 ( Fa)10.5 (m)-6 (i)2.6 (l)2.7 (i)2.6 (al)2.6 ( r)-5.9 (i)2.6 (s)8.9 (k)-12.9 (s)-2 ( )11.3 (f)4.2 (or)-6 ( non)10.5 (m)-5.9 (edul)2.6 (l)2.7 (ar)-5.9 (y)8.8 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.141 Td [(c)-2 (anc)-2 (er)-6 (.)4.3 ( J)8.8 ( C)2.6 (l)2.7 (i)2.6 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2005;)-6.6 (90:)-6.6 (5747)]TJ 0 Tc 0 Tw 20.446 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(57)10.5 (53.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -20.783 -1.141 Td [(h)6.7 (ttp)17.6 (:)]TJ -0.002 Tc 0.002 Tw [(/)4.2 (/)-6.6 (w)2.6 (w)2.7 (w)13.4 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (16030170)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 169.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 167.64 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 145.92 Tm [(144.)-6.7 ( A)12.9 (g)-11.2 (os)8.9 (t)-6.6 (i)2.6 (ni)2.7 ( L,)4.3 ( M)15.7 (a)-11.2 (z)8.9 (z)-2 (i)2.6 ( P)2 (,)-6.7 ( )0.5 (C)2.6 (av)8.9 (al)2.6 (i)2.6 (er)-5.9 (e A)2 (.)-6.7 ( M)15.8 (ul)2.6 (t)-6.6 (i)2.6 (pl)2.6 (e pr)-6 (i)-8.3 (m)-5.9 (ar)-6 (y)8.9 ( m)-6 (al)2.6 (i)13.4 (g)-11.2 (nant)4.2 ( t)-6.6 (u)10.6 (m)-6 (ou)10.6 (r)-6 (s)-2 (:)4.3 ( )]TJ 0 -1.141 Td [(g)-11.2 (e)10.5 (m)-6 (i)2.7 (s)-2 (t)-6.6 (oc)-2 (y)8.9 (t)-6.6 (i)2.6 (c)-2 ( as)8.9 (t)-6.6 (r)-6 (o)10.6 (c)-2 (y)8.8 (t)-6.6 (om)4.9 (a w)13.5 (i)2.6 (t)-6.6 (h l)2.6 (ept)-6.6 (om)-5.9 (eni)2.6 (n)10.5 (g)-11.2 (eal)2.6 ( s)-2 (p)10.5 (r)-5.9 (eadi)2.5 (ng and papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a.)4.3 ( A)2 ( c)-2 (as)8.9 (e r)-5.9 (epo)10.5 (r)-5.9 (t)4.2 (.)-6.6 ( A)2 (c)8.8 (t)-6.6 (a N)2.6 (eu)10.6 (r)-6 (ol)2.6 ( \()-6 (N)2.6 (a)10.6 (pol)2.6 (i)2.6 (\))-6 ( 1990;)-6.6 (12:)-6.6 (305)]TJ 0 Tc 0 Tw 29.696 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(310)10.5 (.)-6.6 ( )]TJ 0.007 Tw -30.033 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (2251958)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 309.12 108 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 105.96 222.48 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 84.36 Tm [(145.)-6.7 ( S)2 (or)-6 (av)8.9 (i)2.6 (a C)2.6 (,)4.2 ( )0.5 (S)1.9 (u)10.5 (gg)-11.2 ( S)1.9 (L)10.6 (,)-6.7 ( B)2 (er)4.9 (k)-2 ( )11.2 (T,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( Fa)10.5 (m)-6 (i)2.6 (l)2.6 (i)2.7 (al)2.6 ( adenom)-6 (at)-6.6 (ous)8.8 ( )0.5 (pol)2.7 (y)8.8 (pos)-2 (i)2.7 (s)]TJ 0 Tc 0 Tw 31.62 0 Td (-)Tj -0.002 Tc 0.007 Tw -31.62 -1.141 Td [(as)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (ed )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d c)-2 (anc)-2 (e)10.5 (r)-5.9 (:)4.2 ( a c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.7 (,)-6.7 ( pa)10.5 (t)-6.6 (hol)2.6 (og)-11.3 (i)2.7 (c)-2 (al)2.6 (,)4.3 ( and )11.3 (m)-5.9 (ol)2.6 (ec)-2 (ul)2.6 (ar)-6 ( )11.3 (g)]TJ 0.002 Tw 29.207 0 Td [(ene)10.5 (t)-6.6 (i)2.6 (c)-2 (s)-2 ( )]TJ 0.007 Tw -29.207 -1.152 Td [(s)-2 (t)-6.6 (udy)8.9 (.)-6.6 ( A)1.9 (m)4.9 ( J)8.9 ( P)2 (at)-6.6 (hol)2.6 ( 1999)10.5 (;)4.2 (154:)-6.6 (127)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 15.022 0 Td [(135)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -15.022 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9916927)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 46.44 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 44.4 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(146.)-6.7 ( S)2 (t)4.3 (r)-6 (a)10.5 (t)-6.6 (a)10.5 (k)-12.8 (i)2.6 (s)-2 ( C)2.6 (A)2 (,)4.2 ( C)2.6 (our)-5.9 (c)8.9 (out)-6.6 (s)-2 (a)10.6 (k)-12.9 (i)2.6 (s)-2 ( N)2.6 (A)2 (,)4.2 ( A)2 (bat)-6.6 (i)13.5 ( A)1.9 (,)-6.6 ( e)10.5 (t)4.3 ( )11.3 (al)2.6 (.)-6.6 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )11.3 (g)-11.2 (l)2.6 (and )]TJ -0.004 Tw 0 -1.152 Td [(abnor)-5.9 (m)-6 (al)2.6 (i)2.6 (t)-6.6 (i)2.6 (es)-2 ( )-10.6 (i)2.6 (n pat)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( w)]TJ 0.007 Tw 11.739 0 Td [(i)2.6 (t)-6.6 (h t)-6.7 (he)10.5 ( s)-2 (y)8.9 (ndr)-6 (om)-6 (e)10.6 ( o)10.5 (f)-6.6 ( s)-2 (po)10.6 (t)-6.7 (t)-6.6 (y)8.9 ( s)8.9 (k)-12.9 (i)2.6 (n pi)13.5 (gm)-5.9 (ent)-6.6 (a)10.5 (t)-6.6 (i)2.6 (on,)-6.6 ( )]TJ -11.739 -1.141 Td [(m)-6 (y)8.9 (x)8.9 (om)-5.9 (as)-2 (,)-6.6 ( endoc)8.9 (r)-6 (i)2.7 (ne ov)8.9 (er)-6 (ac)-2 (t)-6.6 (i)2.6 (v)8.9 (i)2.6 (t)-6.6 (y)8.9 (,)-6.6 ( and s)-2 (c)-2 (hw)13.5 (annom)-6 (as)-2 ( )11.2 (\()-5.9 (C)2.6 (ar)-6 (ney)8.9 ( c)-2 (o)10.5 (m)-6 (pl)2.6 (ex)8.8 (\))-5.9 (.)-6.6 ( J)8.8 ( )]TJ 0 -1.152 Td [(C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.7 (nol)2.6 ( M)15.8 (et)-6.6 (ab 1997;)-6.6 (82:)-6.6 (2037)]TJ 0 Tc 0 Tw 16.12 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(2043.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -16.457 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)]TJ 12.12 0 Td [(/)-6.6 (pubm)-5.9 (ed/)-6.6 (9215269)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 463.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 461.28 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 439.68 Tm [(147.)-6.7 ( M)15.8 (ar)-6 (s)-2 (h D)2.6 (J)-2 (,)4.2 ( D)2.7 (ahi)2.6 (a P)12.8 (L,)-6.6 ( C)2.6 (ar)-6 (on)10.6 ( S)1.9 (,)4.3 ( et)4.3 ( al)2.7 (.)4.2 ( G)-6.6 (e)10.5 (r)-5.9 (m)-6 (l)2.6 (i)13.5 (ne P)2 (T)-10.6 (E)2 (N)13.4 ( m)-5.9 (u)10.5 (t)-6.6 (at)-6.7 (i)2.7 (ons)8.8 ( i)2.6 (n )]TJ 0 -1.152 Td [(C)2.6 (ow)13.4 (den s)-2 (y)8.9 (ndr)-6 (om)-6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 8.641 0 Td [(l)2.6 (i)2.6 (k)-12.9 (e )11.3 (f)4.2 (am)-6 (i)2.6 (l)2.6 (i)2.7 (es)-2 (.)-6.6 ( J)-2 ( M)15.8 (ed G)-6.6 (ene)10.5 (t)-6.6 ( 1)10.5 (9)10.5 (98;)-6.6 (35:)-6.7 (881)]TJ 0 Tc 0 Tw 17.217 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(885.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e)-11.2 ( )]TJ -0.006 Tc 0.006 Tw -26.196 -1.141 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (983)]TJ (2031)Tj EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 642.96 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 420.36 412.32 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 390.72 Tm [(148.)-6.7 ( M)15.8 (az)-2 (z)8.8 (af)-17.5 (er)4.9 (r)-6 (i)2.7 ( E)1.9 (L.)4.2 ( P)2 (api)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a:)4.2 ( )11.3 (f)4.3 (ac)-2 (t)-6.6 (or)-6 (s)8.9 ( i)2.6 (n)10.5 (f)-17.5 (l)2.6 (uenc)-2 (i)2.6 (n)10.5 (g)-11.2 ( )]TJ 0 -1.152 Td [(pr)-6 (o)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)-2 ( and)10.6 ( c)-2 (ur)4.9 (r)-5.9 (ent)4.2 ( t)-6.6 (h)10.5 (er)-6 (apy)8.9 (.)-6.6 ( S)2 (em)-6 (i)2.7 (n )11.3 (O)-6.6 (nc)-2 (ol)2.6 ( 1)10.5 (98)10.5 (7;)-6.6 (14:)-6.6 (315)]TJ 0 Tc 0 Tw 25.315 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(332.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e )]TJ -0.006 Tc 0.006 Tw -25.652 -1.141 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (3306936)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 642.96 365.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 420.36 363.36 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 405 341.76 Tm (149.)Tj 0 Tc 0 Tw 1.946 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(Li)2.6 (V)1.9 (ol)2.6 (s)-2 (i)2.6 ( V)1.9 (A)2 (.)-6.6 ( Fol)2.7 (l)2.6 (i)2.6 (c)-2 (ul)2.7 (ar)-6 ( l)2.7 (es)-2 (i)2.6 (ons)-2 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (he )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d.)-6.6 ( )11.3 (I)4.3 (n:)-6.6 ( Li)2.6 (V)1.9 (ol)2.6 (s)-2 (i)2.6 ( V)2 (A)1.9 (,)-6.6 ( ed)10.6 (.)-6.6 ( )]TJ -2.228 -1.141 Td [(S)2 (ur)-5.9 (g)-11.3 (i)2.7 (c)-2.1 (al)2.6 ( P)2 (a)10.5 (t)-6.6 (hol)2.6 (og)-11.2 (y)8.9 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (he)10.6 ( )11.2 (T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d.)-6.6 ( P)2 (hi)2.6 (l)2.7 (adel)2.6 (phi)2.6 (a:)-6.6 ( )22.1 (W)-14.5 (B)2 ( S)1.9 (aunder)-6 (s)-2 (;)4.3 ( 1990)10.6 (:)-6.6 (173)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 0 -1.152 Td (212.)Tj 0 Tc 0 Tw 1.935 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -1.935 -2.141 Td [(150.)-6.7 ( Li)2.6 (V)2 (ol)2.6 (s)-2 (i)2.6 ( V)2 (A)1.9 (.)-6.5 ( P)2 (api)2.6 (l)2.6 (l)2.6 (ar)4.9 (y)8.9 ( l)2.6 (es)-2 (i)2.6 (ons)-2.1 ( )0.5 (of)-6.6 ( t)-6.6 (he)10.6 ( )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d.)-6.6 ( I)4.3 (n:)-6.6 ( Li)2.7 (V)1.9 (ol)2.6 (s)-2 (i)2.6 ( V)1.9 (A)2 (,)-6.6 ( ed)10.6 (.)-6.6 ( S)1.9 (u)10.5 (r)5 (g)-11.3 (i)2.6 (c)8.9 (al)2.6 ( )]TJ 0 -1.141 Td [(P)2 (at)-6.6 (hol)2.6 (og)-11.2 (y)8.8 ( o)10.6 (f)-6.7 ( t)-6.6 (he)10.5 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d.)4.2 ( P)2 (hi)2.6 (l)2.6 (ad)]TJ [(el)2.6 (phi)2.6 (a:)-6.6 ( )22.1 (W)-36.2 (B)12.8 ( S)2 (aund)10.6 (er)-5.9 (s)-2.1 (;)4.3 ( 1990:)-6.6 (136)]TJ 0 Tc 0 Tw 28.196 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td (172.)Tj 0 Tc 0 Tw 1.935 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -30.467 -2.141 Td [(151.)-6.7 ( )11.3 (G)-6.6 (hos)-2 (s)-2 (ei)2.6 (n R)13.5 (.)-6.6 ( U)2.6 (pda)10.5 (t)4.3 (e t)-6.6 (o)10.6 ( t)-6.7 (he)10.5 ( C)2.6 (ol)2.6 (l)2.6 (eg)-11.3 (e o)10.5 (f)-6.6 ( A)12.8 (m)-5.9 (er)-5.9 (i)13.5 (c)-2 (an P)1.9 (at)-6.6 (hol)2.6 (o)10.5 (g)-11.2 (i)2.6 (s)-2 (t)-6.6 (s)8.9 ( )]TJ 0 -1.152 Td [(r)-6 (epor)4.9 (t)-6.6 (i)2.6 (ng on )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)13.5 (nom)-5.9 (as)-2 (.)4.2 ( H)2.6 (ead N)2.6 (ec)8.9 (k)-2 ( P)2 (at)-6.6 (h)10.5 (ol)2.6 ( 2009;)-6.6 (3:)-6.7 (86)]TJ 0 Tc 0 Tw 27.261 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(93.)4.3 ( )]TJ 0.007 Tw -27.598 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw [(h)17.6 (ttp)17.5 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)6.6 (l)9.6 (m)]TJ -0.002 Tc 0.002 Tw 14.348 0 Td [(.)-6.6 (ni)2.7 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-6 (ed)10.5 (/)-6.6 (20596997)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 231.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 229.2 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 207.6 Tm [(152.)-6.7 ( )11.3 (G)-6.6 (ar)-6 (dne)10.5 (r)-5.9 ( R)2.6 (E)12.8 (,)-6.6 ( )11.3 (T)-10.6 (u)10.5 (t)-6.6 (t)-6.6 (l)2.6 (e )11.2 (R)-8.2 (M)15.8 (,)-6.6 ( B)1.9 (ur)-6 (m)-6 (an)10.5 ( K)2 (D)2.6 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( P)1.9 (r)-5.9 (o)10.5 (g)-11.2 (nos)-2 (t)-6.6 (i)2.6 (c)8.9 ( i)2.6 (m)-6 (por)5 (t)-6.7 (anc)-2.1 (e)10.6 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.152 Td [(v)8.9 (as)-2 (c)-2 (ul)2.6 (ar)-5.9 ( i)2.6 (nv)8.9 (as)-2 (i)2.6 (on i)2.6 (n papi)2.6 (l)-8.2 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( A)12.8 (r)-6 (c)-2 (h )11.3 (O)-6.6 (t)-6.7 (ol)2.6 (a)10.5 (r)-5.9 (y)8.9 (ng)-11.2 (ol)2.6 ( H)2.6 (ead )]TJ 0 -1.141 Td [(N)2.6 (ec)-2 (k)-2 ( S)1.9 (ur)4.9 (g 2000;)-6.6 (126)10.6 (:)-6.6 (309)]TJ 0 Tc 0 Tw 11.022 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(312.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -11.359 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (10722002)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 169.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 167.64 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 145.92 Tm [(153.)-6.7 ( M)15.8 (ai)2.6 ( K)1.9 (T)-10.5 (,)4.2 ( K)2 (hanna P)12.8 (,)-6.6 ( )11.2 (Y)2 (az)8.8 (di)2.6 ( H)-8.3 (M)15.8 (,)-6.6 ( et)-6.7 ( al)2.6 (.)-6.6 ( D)2.6 (i)13.5 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.6 (t)4.2 (i)2.6 (at)-6.6 (ed t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (as)8.9 ( )]TJ 0 -1.141 Td [(w)2.6 (i)2.6 (t)-6.6 (h v)8.8 (as)-2 (c)-2 (ul)2.7 (ar)-5.9 ( i)2.7 (nv)8.9 (as)-2 (i)2.6 (on:)-6.7 ( a )11.3 (c)-2.1 (om)-5.9 (par)-6 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e s)-2 (t)-6.7 (udy)8.8 ( o)10.5 (f)-6.6 ( )11.3 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 (,)-6.6 ( H)2.6 (u)10.5 (r)-6 (t)-6.6 (hl)2.6 (e )11.3 (c)-2 (el)2.6 (l)2.6 ( and )]TJ 0 -1.141 Td [(papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-6 (a.)4.2 ( P)1.9 (at)-6.6 (hol)2.6 (o)10.5 (g)-11.2 (y)8.9 ( 2002;)-6.6 (34)]TJ -0.013 Tc 0.013 Tw 20.717 0 Td [(:)-17.6 (23)-11.3 (9)]TJ 0 Tc 0 Tw 1.935 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(244.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.989 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (12109784)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 108 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 105.96 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 84.36 Tm [(154.)-6.7 ( Fu)10.5 (r)-6 (l)2.6 (an J)-2 (C)2.6 (,)4.3 ( B)2 (edar)-5.9 (d)10.5 ( )11.2 (Y)2 (C)2.6 (,)-6.6 ( R)2.6 (os)-2 (en )11.3 (I)-6.7 (B)2 (.)4.3 ( C)2.6 (l)2.6 (i)2.6 (ni)2.7 (c)-2.1 (opat)-6.6 (hol)2.6 (og)-11.3 (i)2.7 (c)-2 ( s)-2 (i)13.4 (g)-11.2 (ni)13.5 (f)-17.5 (i)2.6 (c)-2 (anc)-2 (e)10.5 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.141 Td [(hi)2.6 (s)-2 (t)-6.6 (ol)2.6 (og)-11.2 (i)2.6 (c)-2 ( v)8.8 (as)-2 (c)-2 (ul)2.7 (ar)4.9 ( i)2.6 (nv)8.9 (as)-2 (i)-8.3 (on i)2.6 (n papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( and )11.3 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.7 (ar)]TJ 0 Tc 0 Tw 22.989 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )-10.6 (c)-2 (a)10.5 (r)-6 (c)-1.9 (i)2.6 (nom)-6 (as)8.8 (.)-6.6 ( J)-2 ( )]TJ 0.007 Tw -23.272 -1.152 Td [(A)2 (m)-6 ( C)2.6 (ol)2.6 (l)2.6 ( S)1.9 (ur)4.9 (g 2004;)-6.6 (198)10.5 (:)4.2 (341)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 12.576 0 Td [(348.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -12.576 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (14992733)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 46.44 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 44.4 228.72 0.841 re f EMC endstream endobj 968 0 obj 27928 endobj %% Contents for page 111 %% Original object ID: 223 0 969 0 obj << /Length 970 0 R >> stream Q q BT /Xi109 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 970 0 obj 246 endobj %% Original object ID: 11621 0 971 0 obj [ 2810 0 R 2811 0 R 2812 0 R 2813 0 R 2814 0 R 2815 0 R 2816 0 R 2817 0 R 2818 0 R 2819 0 R 2820 0 R 2821 0 R 2822 0 R 2823 0 R 2824 0 R ] endobj %% Contents for page 112 %% Original object ID: 224 0 972 0 obj << /Length 973 0 R >> stream q endstream endobj 973 0 obj 2 endobj %% Contents for page 112 %% Original object ID: 11622 0 974 0 obj << /Length 975 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (49)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(155.)-6.7 ( Fal)2.6 (v)8.9 (o L,)4.2 ( C)2.7 (at)-6.6 (ani)2.6 (a A)1.9 (,)4.3 ( )11.3 (D)2.6 (')-6.7 (A)2 (ndr)-6 (ea V)12.9 (,)-6.7 ( e)10.6 (t)-6.6 ( al)2.6 (.)4.3 ( P)1.9 (r)-5.9 (o)10.5 (g)-11.2 (n)10.5 (os)-2 (t)-6.7 (i)2.7 (c)-2 ( i)2.6 (m)-6 (po)10.5 (r)-6 (t)-6.6 (an)10.5 (c)-2 (e o)10.5 (f)-6.6 ( )]TJ 0 -1.152 Td [(hi)2.6 (s)-2 (t)-6.6 (ol)2.6 (og)-11.2 (i)2.6 (c)-2 ( v)8.8 (as)-2 (c)-2 (ul)2.7 (ar)4.9 ( i)2.6 (nv)8.9 (as)-2 (i)-8.3 (on i)2.6 (n papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)4.9 (c)-2 (i)2.6 (nom)-5.9 (a.)4.3 ( A)1.9 (nn S)2 (ur)5 (g )]TJ 0.002 Tw 0 -1.141 Td [(2005;)-6.6 (241:)-6.6 (640)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(646.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -6.435 -1.152 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)6.6 (l)9.6 (m)1.1 (.n)6.6 (i)9.7 (h)6.6 (.)11.3 (g)]TJ -0.002 Tc 0.002 Tw 11.076 0 Td [(ov)8.8 (/)-6.6 (pubm)-6 (ed/)-6.6 (15798466)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 473.88 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 452.28 Tm [(156.)-6.7 ( E)2 (l)2.6 (i)2.6 (s)-2 (ei)2.6 ( R)2.6 (,)-6.6 ( C)2.6 (os)8.9 (c)-2 (i)2.6 ( B)2 (,)4.2 ( )0.5 (R)2.5 (om)-6 (ei)2.6 ( C)2.6 (,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( P)12.9 (r)-6 (o)10.5 (g)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)-2 ( s)-2 (i)2.6 (g)-11.2 (ni)13.5 (f)-17.5 (i)2.6 (c)-2 (an)10.5 (c)-2 (e o)10.5 (f)-6.6 ( s)-2 (o)10.5 (m)-5.9 (at)-6.6 (i)2.6 (c)8.9 ( )]TJ 0 -1.141 Td [(R)2.6 (E)2 (T)-10.6 ( onc)-2 (o)10.5 (g)-11.2 (ene)10.6 ( )11.2 (m)-5.9 (ut)-6.6 (a)10.5 (t)-6.6 (i)2.6 (ons)-2 ( i)2.6 (n s)-2 (po)10.5 (r)-6 (adi)2.6 (c)-2 ( )11.3 (m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)4.2 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)-6 (:)4.3 ( a 10)]TJ 0 Tc 0 Tw 29.967 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(y)8.9 (ear)-6 ( )]TJ -0.005 Tc 0.005 Tw -30.304 -1.152 Td [(f)-9.6 (o)-3.4 (llo)-3.3 (w)]TJ 0 Tc 0 Tw 2.533 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up s)-2 (t)-6.6 (udy)8.9 (.)-6.6 ( J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)12.9 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2008;)-6.6 (93)10.5 (:)-6.6 (682)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 21.011 0 Td [(687)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -23.88 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (18073307)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 412.32 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 390.72 Tm [(157.)-6.7 ( Li)2.6 (V)2 (ol)2.6 (s)-2 (i)2.7 ( V)2 (A)1.9 (.)-6.5 ( U)2.6 (nus)-2 (ual)13.5 ( v)8.9 (ar)-6 (i)2.6 (ant)-6.6 (s)-2 ( o)10.5 (f)-6.6 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2.1 (ar)-6 (c)-1.9 (i)2.6 (nom)-6 (a)10.5 (.)-6.6 ( )11.3 (I)-6.6 (n:)4.3 ( )]TJ 0 -1.152 Td [(M)15.8 (a)-11.2 (z)-2 (z)8.8 (af)-17.5 (er)-6 (r)-5.9 (i)13.4 ( E)2 (L,)4.3 ( K)2 (r)-6 (ei)2.6 (s)-2 (ber)4.9 (g R)2.6 (A)2 (,)-6.6 ( B)1.9 (a)10.6 (r)-6 ( R)2.6 (S)2 (,)4.2 ( eds)8.9 (.)-6.6 ( A)2 (dv)8.9 (anc)-2 (es)-2 ( i)2.7 (n E)2 (ndoc)8.9 (r)-6 (i)2.6 (nol)2.7 (og)-11.2 (y)8.9 ( )]TJ 0 -1.141 Td [(and M)15.7 (et)-6.6 (abol)2.7 (i)2.6 (s)-2 (m)-6 (.)-6.6 ( S)2 (t)4.2 (.)-6.6 ( Loui)13.5 (s)-2.1 (:)-6.6 ( M)15.8 (os)-2 (b)]TJ 0 Tc 0 Tw (y)Tj 14.946 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(Y)2 (ear)-6 ( B)2 (oo)10.5 (k)-12.8 (;)4.2 ( 19)10.5 (94:)-6.6 (39)]TJ 0 Tc 0 Tw (-)Tj -0.013 Tc 0.013 Tw 9.152 0 Td [(5)-11.3 (4.)]TJ 0 Tc 0 Tw 1.37 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -25.804 -2.141 Td [(158.)-6.7 ( V)2 (uon)10.5 (g H)2.6 (G)4.2 (,)-6.5 ( K)1.9 (ondo)10.5 ( )11.2 (T,)-6.7 ( )0.5 (P)1.9 (ha)10.5 (m)-6 ( )11.3 (TQ)-6.6 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( P)1.9 (r)-5.9 (o)10.5 (g)-11.2 (n)10.5 (os)-2 (t)-6.6 (i)2.6 (c)-2 ( s)-2 (i)13.4 (g)-11.2 (ni)13.5 (f)-17.5 (i)2.6 (c)-2 (anc)-2 (e)10.5 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.141 Td [(di)2.6 (f)-6.6 (f)-6.7 (us)-2 (e )11.2 (s)-2 (c)-2 (l)2.6 (er)-6 (os)-2 (i)2.6 (n)10.5 (g)-11.2 ( v)8.9 (ar)-5.9 (i)2.6 (ant)4.3 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (no)10.6 (m)-6 (a:)4.2 ( a s)-2 (y)8.8 (s)-2 (t)-6.6 (e)10.6 (m)-6 (at)-6.6 (i)2.6 (c)8.9 ( r)-5.9 (ev)8.9 (i)2.6 (ew)13.5 ( )]TJ 0 -1.152 Td [(and m)-6 (e)10.5 (t)-6.6 (a)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 4.5 0 Td [(anal)2.6 (y)8.8 (s)-2 (i)2.7 (s)-2.1 (.)-6.6 ( E)2 (ur)5 ( J)8.8 ( E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( 2017;)-6.6 (1)10.5 (76:)-6.6 (43)10.5 (1)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 18.163 0 Td [(439.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.663 -1.141 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (28183787)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.76 303.84 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 301.8 234.24 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 280.2 Tm [(159.)-6.7 ( P)2 (a)10.5 (t)-6.6 (el)2.6 ( K)1.9 (N)2.7 (.)-6.7 ( N)2.7 (oni)2.7 (nv)8.9 (as)-2 (i)2.6 (v)8.9 (e E)1.9 (nc)-2 (aps)-2 (ul)2.6 (at)-6.6 (ed Fol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)-8.2 (ar)-5.9 ( V)1.9 (ar)-6 (i)2.6 (an)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( P)2 (api)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( )]TJ 0 -1.152 Td [(T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d ")-5.7 (C)2.6 (anc)-2 (e)10.6 (r)-6 (")5.2 ( \()-6 (o)10.6 (r)-6 ( N)2.6 (o)10.5 (t)4.3 (\))-6 (:)4.3 ( )11.3 (T)-10.6 (i)2.6 (m)-6 (e )11.3 (f)-6.6 (or)4.9 ( a N)2.6 (a)10.5 (m)-6 (e C)2.6 (han)10.5 (g)-11.2 (e)10.5 (.)-6.6 ( J)-2 (A)2 (M)15.8 (A)1.9 ( O)-6.6 (nc)-2 (ol)2.6 ( )]TJ 0.002 Tw 0 -1.141 Td [(2016;)-6.6 (2:)-6.7 (1005)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1006.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.152 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (27077657)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.76 242.16 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 240.12 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 218.52 Tm [(160.)-6.7 ( N)2.7 (i)13.4 (k)-12.8 (i)13.4 (f)-17.4 (or)-5.9 (ov)8.9 ( Y)1.9 (E)2 (,)4.3 ( S)1.9 (eet)-6.6 (h)10.5 (al)2.6 (a R)2.6 (R)2.6 (,)-6.6 ( )11.2 (T)-10.5 (al)2.6 (l)2.6 (i)2.7 (ni)2.6 ( G)-6.6 (,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( N)13.5 (om)-5.9 (enc)-2 (l)2.6 (at)-6.6 (u)10.5 (r)-6 (e R)2.6 (ev)8.9 (i)2.6 (s)-2 (i)2.6 (on )11.3 (f)-17.5 (or)4.9 ( )]TJ 0 -1.141 Td [(E)2 (nc)-2 (aps)-2 (ul)2.6 (at)-6.6 (ed Fol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( )11.2 (V)2 (ar)-6 (i)2.6 (ant)-6.6 ( o)10.5 (f)-6.6 ( P)2 (api)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( T)-10.6 (hy)8.8 (r)4.9 (oi)2.6 (d C)2.6 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a:)4.3 ( A)1.9 ( )]TJ 0 -1.141 Td [(P)2 (ar)-5.9 (adi)2.6 (gm)-5.9 ( S)]TJ -0.004 Tw 5.217 0 Td [(hi)13.4 (f)-6.6 (t)-6.6 ( t)-6.6 (o )-10.6 (R)2.6 (educ)8.9 (e )-10.6 (O)-6.6 (v)8.9 (er)-5.9 (t)4.2 (r)-5.9 (eat)4.2 (m)-5.9 (en)10.5 (t)-6.6 ( )-10.7 (o)10.6 (f)-6.6 ( I)-6.6 (ndol)2.6 (ent)-6.6 ( T)-10.6 (u)10.5 (m)-5.9 (or)-5.9 (s)8.8 (.)-6.6 ( J)-2 (A)1.9 (M)15.8 (A)2 ( )-10.6 (O)-6.6 (nc)-2 (ol)2.6 ( )]TJ 0.002 Tw -5.217 -1.152 Td [(2016;)-6.6 (2:)-6.7 (1023)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1029.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.141 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (27078145)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.76 168 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 165.96 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 144.36 Tm [(161.)-6.7 ( V)2 (i)2.6 (v)8.9 (er)-5.9 (o M)15.8 (,)-6.6 ( K)2 (r)-6 (a)10.5 (f)-6.6 (t)-6.6 ( S)12.8 (,)-6.6 ( B)12.9 (ar)-6 (l)2.7 (et)-6.6 (t)-6.6 (a)10.5 ( J)-2 (A)2 (.)4.2 ( R)2.6 (i)2.7 (s)8.8 (k)-12.8 ( s)8.8 (t)-6.6 (r)-5.9 (a)10.5 (t)-6.6 (i)13.5 (f)-17.5 (i)2.6 (c)-2 (at)4.2 (i)2.6 (on )]TJ [(o)10.5 (f)-17.4 ( )11.2 (f)-6.6 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( v)8.8 (ar)-6 (i)2.6 (ant)-6.7 ( o)10.6 (f)-6.7 ( )]TJ 0 -1.152 Td [(papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-6 (a.)4.3 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d 2013;)-6.6 (23)10.6 (:)-6.6 (273)]TJ 0 Tc 0 Tw 21.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(279.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -21.88 -1.141 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (23025507)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.76 119.04 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 117 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 95.4 Tm [(162.)-6.7 ( P)2 (i)2.6 (ana S)12.8 (,)-6.6 ( F)11.2 (r)-6 (as)-2 (ol)2.6 (dat)-6.6 (i)2.6 ( )11.3 (A)1.9 (,)-6.6 ( )0.5 (D)2.5 (i)2.7 ( Fel)2.6 (i)2.6 (c)-2 (e E)1.9 (,)4.3 ( et)4.2 ( al)2.6 (.)4.3 ( E)2 (nc)8.8 (aps)-2 (ul)]TJ 24.033 0 Td [(at)-6.6 (ed w)13.5 (el)2.6 (l)]TJ 0 Tc 0 Tw 3.924 0 Td (-)Tj -0.002 Tc -0.004 Tw -27.957 -1.152 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed f)-6.6 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)]TJ 0 Tc 0 Tw 9.696 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(p)10.5 (at)-6.6 (t)-6.6 (e)10.5 (r)-6 (ned )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (as)-2 ( do)10.5 ( not)4.3 ( pl)2.6 (ay)8.8 ( a )]TJ -10.033 -1.141 Td [(s)-2 (i)2.6 (g)-11.2 (ni)13.5 (f)-17.4 (i)2.6 (c)-2 (ant)4.2 ( r)-5.9 (ol)2.6 (e)10.5 ( )0.5 (i)2.6 (n t)-6.6 (he)10.5 ( )11.2 (f)-17.4 (a)10.5 (t)-6.6 (a)10.5 (l)2.6 (i)2.6 (t)-6.6 (y)8.9 ( r)-6 (at)-6.6 (es)-2 ( )11.3 (f)-6.6 (r)-6 (o)10.6 (m)-6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)4.9 (c)-2 (i)2.6 (nom)-5.9 (a.)4.3 ( A)1.9 (m)5 ( J)-2.1 ( )0.5 (S)1.9 (u)10.5 (r)4.9 (g)-11.2 ( )]TJ 0 -1.141 Td [(P)2 (at)-6.6 (hol)2.6 ( 2010;)-6.6 (34)10.5 (:)-6.6 (868)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 8.989 0 Td [(872)10.5 (.)4.3 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (ab)-11.2 (l)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -8.989 -1.152 Td [(ht)-6.7 (t)-6.6 (ps)]TJ 2.163 0 Td [(:)-6.6 (/)4.2 (/)-6.6 (w)2.7 (w)2.6 (w)13.4 (.)-6.6 (nc)-2 (bi)2.7 (.)-6.7 (nl)2.6 (m)-6 (.)-6.5 (ni)2.6 (h.)4.2 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-6 (ed)10.5 (/)-6.6 (20463572)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.76 44.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 42.72 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(163.)-6.7 ( Li)2.6 (u J)8.8 (,)4.3 ( S)1.9 (i)2.7 (ng)-11.2 (h)10.5 ( B)2 (,)4.2 ( )11.3 (T)-10.6 (al)2.6 (l)2.6 (i)-8.3 (ni)2.6 ( G)-6.6 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( Fol)2.7 (l)2.6 (i)2.6 (c)-2 (ul)2.7 (ar)-6 ( v)8.9 (ar)-5.9 (i)2.6 (ant)-6.6 ( o)10.5 (f)-6.6 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (:)-6.6 ( a)10.5 ( c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (opat)-6.6 (h)10.5 (ol)2.6 (og)-11.3 (i)2.7 (c)-2 ( s)8.8 (t)-6.6 (udy)8.9 ( o)10.5 (f)-17.5 ( )11.3 (a )0.5 (p)10.5 (r)-6 (obl)2.6 (em)4.9 (at)-6.6 (i)2.6 (c)-2 ( ent)-6.6 (i)13.4 (t)-6.6 (y)8.9 (.)-6.6 ( C)2.6 (anc)-2 (er)4.9 ( )]TJ 0.002 Tw 0 -1.141 Td [(2006;)-6.6 (107:)-6.6 (1255)]TJ 0 Tc 0 Tw 6.652 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1264.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.989 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (16900519)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 473.88 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 452.28 Tm [(164.)-6.7 ( P)2 (aul)2.6 (s)-2 (on V)2 (A)12.8 (,)-6.6 ( S)2 (hi)2.6 (v)8.9 (das)-2 (ani)2.6 ( P)2 (,)-6.6 ( A)2 (n)10.6 (g)-11.3 (el)2.6 (l)2.6 ( )11.3 (T)-10.6 (E)2 (,)4.2 ( et)4.2 ( al)2.6 (.)4.2 ( )11.3 (N)2.6 (I)-6.6 (FT)-10.5 (P)12.8 ( A)1.9 (c)-2 (c)-2 (ount)4.3 (s)-2 ( )11.2 (f)-6.6 (or)4.9 ( O)-6.6 (v)8.8 (e)10.6 (r)-6 ( )]TJ 0 -1.141 Td [(H)2.6 (al)2.6 (f)-6.6 ( o)10.5 (f)-6.6 ( ")-5.7 (C)2.6 (ar)-5.9 (c)-2 (i)2.6 (no)10.6 (m)-6 (as)-2 (")5.2 ( H)2.7 (ar)4.9 (bor)-5.9 (i)2.6 (ng R)2.6 (A)2 (S)1.9 ( M)15.8 (ut)-6.6 (at)-6.6 (i)2.6 (ons)-2 (.)-6.6 ( )11.3 (Thy)8.9 (r)-6 (oi)2.6 (d )0.5 (2017.)-6.6 ( )0.5 (A)1.9 (v)8.9 (ai)2.6 (l)2.6 (abl)2.7 (e )]TJ -0.006 Tc 0.006 Tw 0 -1.152 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (onl)2.6 (i)2.6 (nel)2.7 (i)2.6 (br)-5.9 (ar)-6 (y)8.9 (.)-6.6 (w)13.5 (i)2.6 (l)-8.3 (ey)8.9 (.)-6.6 (c)-2 (om)-5.9 (/)-6.7 (w)13.5 (ol)2.6 (1/)-6.6 (doi)2.6 (/)-6.6 (10.)-6.7 (1002)10.5 (/)-6.6 (c)-2 (nc)-2 (y)8.8 (.)-6.6 (21830/)4.3 (f)-6.6 (ul)2.6 (l)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 721.08 426.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 420.36 424.92 300.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 403.32 Tm [(165.)-6.7 ( B)2 (r)-6 (andl)2.6 (e)10.6 (r)-6 ( )11.3 (T)-10.6 (C)2.6 (,)4.3 ( Li)2.6 (u C)2.6 (Z)11.2 (,)-6.7 ( C)2.6 (ho M)15.7 (,)-6.6 ( e)10.6 (t)-6.7 ( al)2.6 (.)4.3 ( D)2.6 (oes)-2 ( N)2.6 (on)10.6 (i)2.6 (nv)8.9 (as)-2 (i)-8.2 (v)8.9 (e Fol)2.6 (l)-8.3 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( )]TJ -0.015 Tw 0 -1.141 Td [(T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d )-21.6 (N)2.6 (eopl)2.6 (as)-1.9 (m)4.9 ( W)-36.3 (i)13.5 (t)-6.6 (h)10.5 ( )-10.7 (P)1.9 (api)2.6 (l)2.6 (l)2.6 (ar)-16.8 (y)]TJ 0 Tc 0 Tw 14.446 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(Li)2.6 (k)-12.9 (e N)2.7 (uc)-2 (l)2.6 (ear)4.9 ( F)11.2 (eat)-6.6 (ur)-6 (es)8.8 ( \()-5.9 (N)13.5 (I)-6.7 (F)11.2 (T)-10.6 (P)2 (\))-6 ( H)2.7 (av)8.9 (e a )]TJ -14.783 -1.152 Td [(U)2.6 (ni)2.6 (q)-11.2 (ue M)15.7 (ol)2.6 (e)]TJ [(c)-2 (ul)2.6 (ar)-6 ( P)2 (r)-6 (o)10.5 (f)-17.4 (i)2.6 (l)2.6 (e? A)1.9 (m)5 ( J)-2 ( C)2.7 (l)2.6 (i)2.6 (n P)2 (at)-6.6 (hol)2.6 ( )0.5 (20)10.5 (18.)4.3 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (ab)-11.2 (l)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 0 -1.141 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (30052723)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 639.24 365.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 363.36 234.24 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 341.76 Tm [(166.)-6.7 ( J)-2 (i)2.7 (an)10.5 (g)-11.2 ( )11.3 (X)-8.9 (S)12.8 (,)-6.6 ( H)2.6 (a)10.5 (r)-5.9 (r)-6 (i)2.6 (s)-2 (on )11.3 (G)-6.6 (P)1.9 (,)4.3 ( D)2.6 (at)-6.7 (t)-6.6 (o)10.6 ( M)15.8 (B)1.9 (.)-6.6 ( Y)2 (oung )11.2 (I)-6.6 (n)10.6 (v)8.8 (es)-2 (t)-6.6 (i)2.6 (g)-11.2 (at)-6.6 (o)10.5 (r)-5.9 ( C)2.6 (hal)2.6 (l)2.6 (eng)-11.2 (e)10.5 (:)-6.6 ( )]TJ 0 -1.141 Td [(M)15.8 (o)-11.2 (l)2.6 (ec)-2 (ul)2.6 (ar)-5.9 ( t)-6.6 (es)-2 (t)-6.6 (i)2.6 (n)10.6 (g i)2.6 (n noni)2.6 (nv)8.9 (as)]TJ 12.848 0 Td [(i)-8.3 (v)8.9 (e f)-17.5 (ol)2.6 (l)2.7 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d neopl)2.6 (as)-2 (m)-5.9 ( w)13.5 (i)2.6 (t)-6.6 (h papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)]TJ 0 Tc 0 Tw 19.109 0 Td (-)Tj -0.002 Tc 0.007 Tw -31.957 -1.152 Td [(l)2.6 (i)2.6 (k)-12.9 (e nuc)-2 (l)2.6 (ear)4.9 ( )11.3 (f)-17.5 (ea)10.5 (t)-6.6 (ur)-5.9 (e)10.5 (s)-2 (.)4.3 ( C)2.6 (anc)-2 (er)-5.9 ( C)2.6 (y)8.9 (t)-6.6 (opat)-6.6 (hol)2.6 ( 20)10.5 (16;)-6.6 (12)10.6 (4:)-6.6 (893)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 24.446 0 Td [(900)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -24.446 -1.141 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (27893191)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 639.24 303.84 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 301.8 234.24 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 280.2 Tm [(167.)-6.7 ( S)2 (on)10.5 (g S)2 (J)-2 (,)4.2 ( Li)2.6 (V)2 (ol)2.6 (s)-2 (i)2.6 ( V)2 (A)2 (,)-6.7 ( M)15.8 (ont)-6.6 (one K)1.9 (,)4.3 ( B)2 (al)2.6 (oc)-2 (h Z)11.2 (.)-6.6 ( P)12.8 (r)-5.9 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 23.38 0 Td [(oper)-6 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e f)-17.5 (eat)-6.6 (u)10.6 (r)-6 (es)8.9 ( )-10.6 (o)10.5 (f)-6.6 ( )]TJ 0.002 Tw -23.38 -1.152 Td (non)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 2 0 Td [(i)2.6 (nv)8.8 (as)-2 (i)-8.3 (v)8.9 (e )0.5 (f)-17.5 (ol)2.6 (l)2.7 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( )11.3 (t)-6.6 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d neopl)2.6 (as)-2 (m)-5.9 (s)-2 ( w)13.4 (i)2.6 (t)-6.6 (h pa)10.5 (pi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)]TJ 0 Tc 0 Tw 21.902 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(l)-8.3 (i)2.6 (k)-12.8 (e nuc)-2 (l)2.6 (ear)4.9 ( )]TJ -24.239 -1.141 Td [(f)-6.6 (eat)-6.6 (u)10.5 (r)-5.9 (es)-2 (:)4.3 ( A)1.9 (n anal)2.7 (y)8.8 (s)-2 (i)2.6 (s)-2 ( o)10.5 (f)-6.5 ( t)4.3 (hei)2.6 (r)-5.9 ( c)-1.9 (y)8.8 (t)-6.6 (ol)2.6 (og)-11.2 (i)2.6 (c)-2 (al)2.6 (,)4.3 ( G)-6.7 (ene)10.6 ( E)1.9 (x)8.9 (pr)-5.9 (es)-2 (s)-1.9 (i)2.6 (on C)2.6 (l)2.6 (as)-2 (s)-2 (i)13.5 (f)-17.5 (i)2.6 (er)4.9 ( and )]TJ 0 -1.152 Td [(s)-2 (onogr)-5.9 (aphi)2.6 (c)-2 ( )11.3 (f)-17.5 (i)2.6 (ndi)2.6 (n)10.6 (g)-11.3 (s)8.9 (.)-6.6 ( C)2.6 (y)8.9 (t)-6.6 (opat)-6.6 (hol)2.6 (o)10.6 (g)-11.3 (y)8.9 ( 20)]TJ 0.002 Tw [(17;)-6.6 (28)10.5 (:)-6.6 (488)]TJ 0 Tc 0 Tw 21.88 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(494.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.217 -1.141 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (29165886)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 639.24 229.56 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 227.52 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 205.92 Tm [(168.)-6.7 ( v)8.9 (an H)2.6 (eer)-5.9 (den)10.5 ( J)-2 (A)2 (,)4.2 ( H)13.5 (ay)8.8 ( I)-6.6 (D)2.6 (,)-6.6 ( )11.3 (G)-6.6 (oel)2.6 (l)2.6 (ner)-5.9 ( J)-2.1 (R)13.5 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( Fol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h c)-2 (aps)-2 (ul)2.6 (ar)-5.9 ( )11.3 (i)2.6 (nv)8.9 (as)-2 (i)2.6 (on al)2.6 (one:)-6.6 ( a nont)-6.6 (h)10.5 (r)4.9 (eat)-6.6 (e)]TJ [(ni)2.6 (ng m)-5.9 (al)2.6 (i)13.5 (g)-11.2 (nanc)-2 (y)8.9 (.)-6.6 ( )]TJ 0 -1.152 Td [(S)2 (ur)-5.9 (g)-11.3 (e)10.6 (r)-6 (y)8.9 ( 1992;)-6.6 (112)10.5 (:)-6.6 (1130)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 10.75 0 Td [(1136;)-6.6 ( di)2.7 (s)-2 (c)-2 (us)-2 (s)-2 (i)2.6 (on)10.5 ( 1136)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 10.261 0 Td [(1)10.5 (138.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -21.011 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (1455315)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 168 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 165.96 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 144.36 Tm [(169.)-6.7 ( Li)2.6 (V)2 (ol)2.6 (s)-2 (i)2.7 ( V)2 (A)1.9 (,)-6.5 ( A)2 (s)-2 (a)10.5 ( S)2 (L.)4.3 ( )11.3 (T)-10.6 (he)10.5 ( dem)-6 (i)2.6 (s)-2 (e)10.6 ( o)10.5 (f)-6.6 ( )11.2 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( c)8.9 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a )11.2 (o)10.6 (f)-6.6 ( t)-6.6 (he)10.5 ( t)-6.6 (hy)8.8 (r)-5.9 (o)]TJ -0.005 Tc 0.005 Tw [(id)-3.3 ( )]TJ -0.002 Tc -0.004 Tw 0 -1.152 Td [(g)-11.2 (l)2.6 (and.)4.2 ( T)-10.6 (hy)8.8 (r)-5.9 (oi)2.7 (d )-10.6 (1994;)-6.6 (4)10.5 (:)-6.6 (23)10.5 (3)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 11.913 0 Td [(236.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -11.913 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (7920009)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 119.04 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 117 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 95.4 Tm [(170.)-6.7 ( B)2 (r)-6 (enna)10.5 (n M)15.8 (D)2.6 (,)-6.6 ( B)1.9 (er)4.9 (g)-11.2 (s)8.9 (t)-6.7 (r)-5.9 (al)2.6 (h E)1.9 (J)8.9 (,)-6.6 ( v)8.9 (an H)2.6 (eer)-6 (den)10.6 ( J)-2 (A)12.8 (,)-6.6 ( M)15.8 (c)-2 (C)2.6 (onahey)8.9 ( )22.2 (W)-47.2 (M)15.8 (.)4.3 ( )]TJ 0 -1.152 Td [(Fol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.7 (ar)-6 ( )0.5 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)-6 ( )11.3 (t)4.3 (r)-6 (eat)-6.6 (ed)10.5 ( at)4.3 ( t)-6.6 (he)10.5 ( M)15.8 (a)]TJ [(y)8.8 (o C)2.6 (l)-8.2 (i)2.6 (ni)2.6 (c)-12.8 (,)-6.7 ( 1946)10.5 ( t)-6.6 (h)10.5 (r)-5.9 (ou)10.6 (g)-11.3 (h 1970)10.5 (:)-6.6 ( )]TJ 0 -1.141 Td [(i)2.6 (ni)2.6 (t)-6.6 (i)2.6 (al)2.6 ( m)-5.9 (ani)2.6 (f)-17.5 (e)10.5 (s)-2 (t)-6.6 (a)10.5 (t)-6.5 (i)2.6 (ons)-2 (,)4.2 ( pat)4.3 (hol)2.6 (og)-11.2 (i)2.5 (c)-2 ( )11.3 (f)-17.5 (i)2.7 (ndi)2.6 (n)10.5 (g)-11.2 (s)8.9 (,)-6.7 ( )11.3 (t)-6.6 (her)-5.9 (apy)8.8 (,)4.3 ( and ou)10.5 (t)-6.6 (c)-2 (om)-6 (e)10.5 (.)4.3 ( M)15.8 (a)-11.2 (y)8.8 (o )]TJ 0 -1.141 Td [(C)2.6 (l)2.6 (i)2.6 (n P)1.9 (r)-5.9 (oc)-2 ( 1991;)-6.6 (66)10.5 (:)-6.6 (11)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.652 0 Td [(22)10.5 (.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (ab)-11.2 (l)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -9.652 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (1988751)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 44.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 42.72 222.6 0.84 re f EMC endstream endobj 975 0 obj 28305 endobj %% Contents for page 112 %% Original object ID: 225 0 976 0 obj << /Length 977 0 R >> stream Q q BT /Xi110 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 977 0 obj 246 endobj %% Original object ID: 11638 0 978 0 obj [ 2825 0 R 2826 0 R 2827 0 R 2828 0 R 2829 0 R 2830 0 R 2831 0 R 2832 0 R 2833 0 R 2834 0 R 2835 0 R 2836 0 R 2837 0 R 2838 0 R 2839 0 R ] endobj %% Contents for page 113 %% Original object ID: 226 0 979 0 obj << /Length 980 0 R >> stream q endstream endobj 980 0 obj 2 endobj %% Contents for page 113 %% Original object ID: 11639 0 981 0 obj << /Length 982 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (50)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(171.)-6.7 ( Ll)2.6 (oy)8.8 (d R)]TJ 5.598 0 Td [(V)2 (,)-6.7 ( )11.3 (O)-6.6 (s)-2 (a)10.5 (m)-5.9 (ur)-5.9 (a)10.5 ( R)2.6 (Y)2 (,)-6.6 ( K)1.9 (l)2.6 (öppel)2.7 ( )11.2 (G)-6.6 (,)4.3 ( R)2.6 (os)-2 (ai)2.6 ( J)8.9 (,)-6.7 ( )11.3 (eds)-2 (.)-6.6 ( )33 (W)-36.2 (H)13.4 (O)4.3 ( C)2.6 (l)2.6 (as)-2 (s)-2 (i)13.5 (f)-17.5 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (on )]TJ -5.598 -1.152 Td [(o)10.5 (f)-17.5 ( )11.3 (T)-10.5 (u)10.5 (m)-6 (or)-6 (s)8.9 ( o)10.5 (f)-6.6 ( E)1.9 (ndoc)8.9 (r)-6 (i)2.6 (ne )11.3 (O)-6.6 (r)4.9 (g)-11.2 (ans)8.9 (.)-6.6 ( )11.2 (I)-6.6 (n)10.6 (:)-6.7 ( B)2 (os)8.9 (m)-5.9 (an F)11.1 (T,)-6.6 ( )11.3 (J)-2 (a)10.5 (f)-6.6 (f)-17.5 (e)10.6 ( E)1.9 (S)2 (,)4.2 ( La)10.5 (k)-12.9 (hani)2.6 ( S)2 (R)2.6 (,)4.2 ( )]TJ 0 -1.141 Td [(O)-6.6 (h)10.5 (g)-11.2 (a)10.5 (k)-12.8 (i)2.6 ( H)2.6 (,)4.2 ( eds)8.9 (.)-6.6 ( )33 (W)-36.3 (o)10.6 (r)-6 (l)2.6 (d H)2.6 (e)10.5 (al)2.7 (t)-6.7 (h O)4.3 (r)4.9 (g)-11.2 (ani)2.6 (z)8.9 (at)-6.6 (i)2.6 (on C)2.6 (l)2.6 (as)-2 (s)-2 (i)2.6 (f)-17.5 (i)13.5 (c)-2 (at)-6.7 (i)2.7 (on o)10.5 (f)-6.6 ( )11.2 (T)-10.5 (u)10.5 (m)-6 (or)-6 (s)8.9 ( \()-6 (ed)10.5 ( 4\))4.9 (.)-6.6 ( )]TJ 0 -1.152 Td [(Ly)8.8 (on,)-6.6 ( Fr)-5.9 (anc)-2 (e:)4.3 ( )11.2 (I)-6.5 (nt)-6.6 (e)10.5 (r)-5.9 (nat)-6.6 (i)2.6 (on)10.5 (al)2.6 ( A)2 (g)-11.3 (enc)-2 (y)8.8 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( R)2.6 (es)-2 (ea)10.5 (r)-5.9 (c)-2 (h)10.5 ( )11.3 (on C)2.6 (anc)]TJ 25.424 0 Td [(er)4.9 (;)-6.6 ( 2017)10.5 (.)]TJ 0 Tc 0 Tw 3.924 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -29.348 -2.141 Td [(172.)-6.7 ( M)15.8 (ax)-2 (w)13.5 (e)-11.3 (l)2.7 (l)2.6 ( E)1.9 (L,)-6.6 ( P)1.9 (al)2.6 (m)-6 (e )11.3 (C)2.6 (E)1.9 (,)-6.6 ( Fr)-6 (ee)10.5 (m)-5.9 (an )11.3 (J)-2.1 (.)4.3 ( H)2.6 (ur)-6 (t)-6.6 (hl)2.6 (e)10.5 ( )11.3 (c)-2 (el)2.6 (l)2.6 ( t)-6.6 (um)-6 (o)10.5 (r)-5.9 (s)-2 (:)4.2 ( appl)2.6 (y)8.9 (i)2.6 (ng)-11.3 ( )]TJ 0 -1.141 Td [(m)-6 (ol)2.6 (ec)-2 (ul)2.6 (ar)-6 ( )11.3 (m)-6 (ar)4.9 (k)-12.9 (e)10.5 (r)-5.9 (s)8.9 ( t)-6.6 (o)10.5 ( de)10.6 (f)-6.7 (i)2.7 (ne a new)13.5 ( m)-6 (ana)10.6 (g)-11.3 (em)-6 (en)10.5 (t)4.3 ( )11.3 (al)2.6 (g)-11.2 (or)-5.9 (i)2.6 (t)-6.6 (h)10.5 (m)-5.9 (.)4.2 ( A)2 (r)4.9 (c)-2 (h )]TJ 0 -1.152 Td [(O)-6.6 (t)-6.6 (ol)2.6 (ar)-6 (y)8.9 (n)10.5 (g)-11.2 (ol)2.6 ( H)2.6 (ead N)2.7 (ec)8.9 (k)-2 ( )11.2 (S)2 (ur)-6 (g 2006;)-6.6 (1)10.5 (32:)-6.6 (54)]TJ 0 Tc 0 Tw 18.5 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(58.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -18.837 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (16415430)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 412.32 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 390.72 Tm [(173.)-6.7 ( B)2 (el)2.6 (c)-2 (het)-6.6 (z)8.8 ( )11.3 (G)-6.6 (,)4.3 ( C)2.6 (heun)10.5 (g C)2.6 (C)2.6 (,)-6.6 ( F)11.2 (r)-6 (eem)-5.9 (an)10.6 ( J)8.8 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( )11.3 (H)2.6 (ur)-6 (t)-6.6 (hl)2.6 (e c)-2 (el)2.6 (l)2.6 ( )11.3 (t)-6.6 (um)-6 (o)10.6 (r)-6 (s)-2 (:)4.3 ( us)-2 (i)2.6 (n)10.6 (g )]TJ 0 -1.152 Td [(m)-6 (ol)2.6 (ec)-2 (ul)2.6 (ar)-6 ( )11.3 (t)-6.6 (ec)-2 (hni)13.5 (q)-11.2 (ues)-2 ( )11.3 (t)-6.6 (o )11.3 (de)10.6 (f)-17.5 (i)2.6 (ne a )0.5 (nov)8.8 (el)2.6 ( c)-2 (l)2.6 (as)-2 (s)-2 (i)13.5 (f)-17.5 (i)2.7 (c)-2 (at)-6.6 (i)13.5 (on s)-2 (y)8.9 (s)-2 (t)-6.6 (em)4.9 (.)-6.6 ( A)12.8 (r)-5.9 (c)-2 (h )]TJ 0 -1.141 Td [(O)-6.6 (t)-6.6 (ol)2.6 (ar)-6 (y)8.9 (n)10.5 (g)-11.2 (ol)2.6 ( H)2.6 (ead N)2.7 (ec)8.9 (k)-2 ( )11.2 (S)2 (ur)-6 (g 2002;)-6.6 (1)10.5 (28:)-6.6 (237)]TJ 0 Tc 0 Tw 19.054 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(240.)4.2 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -19.391 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (11886336)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 350.76 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 329.16 Tm [(174.)-6.7 ( )11.3 (G)-6.6 (anl)2.6 (y)8.9 ( I)-6.6 (,)4.2 ( R)2.7 (i)2.6 (c)-2 (ar)-5.9 (t)-6.7 (e)10.6 ( Fi)2.6 (l)2.6 (ho J)-2 (,)4.3 ( E)1.9 (n)10.5 (g)-11.2 ( S)12.9 (,)-6.7 ( e)10.6 (t)-6.7 ( )0.5 (al)2.6 (.)4.3 ( )11.2 (G)-6.6 (enom)-6 (i)13.5 (c)-2 ( di)2.6 (s)-2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (on)10.5 ( o)10.5 (f)-6.6 ( H)2.6 (ur)-6 (t)-6.6 (hl)2.6 (e)10.5 ( )]TJ 0 -1.152 Td [(c)-2 (el)2.6 (l)2.6 ( c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.5 ( r)-5.9 (ev)8.9 (eal)2.6 (s)-2 ( a )11.3 (uni)2.7 (q)-11.3 (ue c)-1.9 (l)2.6 (as)-2 (s)8.9 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d m)5 (al)2.6 (i)2.6 (g)-11.2 (nanc)-2 (y)8.8 (.)-6.6 ( J)-2 ( C)2.6 (l)2.7 (i)2.6 (n )]TJ 0 -1.141 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 201)]TJ 0.002 Tw [(3;)-6.6 (9)10.5 (8:)-6.6 (E)1.9 (962)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.576 0 Td [(972.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.576 -1.152 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (23543667)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.76 291.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 289.08 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 267.48 Tm [(175.)-6.7 ( C)2.7 (hen H)13.5 (,)-6.6 ( N)2.6 (i)2.6 (c)-2 (ol)2.6 ( )11.2 (T)-10.5 (L)10.5 (,)-6.6 ( Z)11.2 (ei)2.6 (g)-11.2 (er)5 ( M)15.8 (A)1.9 (,)-6.6 ( et)-6.6 ( al)2.6 (.)4.3 ( H)2.6 (ur)4.9 (t)-6.6 (hl)2.6 (e c)8.9 (el)2.6 (l)2.6 ( neopl)2.6 (as)-2 (m)-6 (s)-2 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (he )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d:)-6.6 ( ar)-5.9 (e)10.5 ( t)-6.6 (he)10.6 (r)-6 (e)10.5 ( )11.3 (f)-17.5 (ac)8.8 (t)-6.6 (or)-6 (s)8.9 ( )11.2 (pr)-5.9 (edi)2.6 (c)-2 (t)-6.6 (i)2.6 (v)8.8 (e o)10.5 (f)-17.5 ( )11.3 (m)-5.9 (al)2.6 (i)2.6 (g)-11.2 (nanc)-2 (y)19.7 (? A)1.9 (nn S)2 (ur)5 (g )]TJ 0.002 Tw 0 -1.152 Td [(1998;)-6.6 (227:)-6.6 (542)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(546.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)]TJ 14.902 0 Td [(ed/)-6.6 (9563543)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 229.56 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 227.52 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 205.92 Tm [(176.)-6.7 ( )11.3 (T)-10.5 (ho)10.5 (m)-5.9 (ps)-2 (on)10.5 ( N)24.4 (W)-36.3 (,)4.3 ( )11.2 (D)2.6 (u)10.6 (nn E)2 (L,)-6.7 ( B)2 (a)10.5 (t)-6.6 (s)-2 (a)10.5 (k)-12.8 (i)2.6 (s)8.9 ( J)-2 (G)4.2 (,)-6.6 ( N)2.6 (i)2.6 (s)-2 (h)10.5 (i)2.7 (y)8.8 (am)-6 (a R)2.6 (H)2.6 (.)-6.6 ( H)2.6 (ur)-6 (t)-6.6 (hl)2.6 (e)10.6 ( c)-2 (el)2.6 (l)2.6 ( )]TJ -0.004 Tw 0 -1.141 Td [(l)2.6 (es)-2 (i)2.6 (ons)-2 ( )-10.6 (o)10.5 (f)-17.5 ( t)-6.6 (he t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d g)-11.2 (l)2.6 (and.)-6.6 ( )-10.6 (S)2 (ur)4.9 (g G)-6.6 (y)8.8 (nec)-2 (ol)2.6 ( )-10.6 (O)-6.6 (bs)8.9 (t)-6.6 (et)4.2 ( )-10.6 (1974;)-6.6 (139)10.6 (:)-6.7 (555)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 28.38 0 Td [(560)10.5 (.)-6.6 ( )]TJ 0.007 Tw -28.38 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (4)]TJ (479589)Tj EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 309.12 180.6 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 178.56 222.48 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 156.96 Tm [(177.)-6.7 ( Lopez)]TJ 0 Tc 0 Tw 4.935 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(P)2 (enabad L)10.5 (,)-6.6 ( )11.3 (C)2.6 (hi)2.6 (u A)1.9 (C)2.6 (,)-6.6 ( H)2.6 (o)10.6 (f)-6.6 (f)-6.7 ( )0.5 (A)12.8 (O)-6.6 (,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( )11.3 (P)1.9 (r)-5.9 (og)-11.2 (no)10.5 (s)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (f)-6.7 (ac)8.9 (t)-6.7 (or)-5.9 (s)8.8 ( i)2.6 (n )]TJ -5.272 -1.141 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h H)2.6 (ur)4.9 (t)-6.6 (hl)2.6 (e c)-2 (el)2.6 (l)2.6 ( )11.2 (neopl)2.6 (as)-2 (m)-5.9 (s)-2 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.7 (he )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d.)-6.6 ( C)2.6 (anc)-2 (e)10.5 (r)-5.9 ( 2003)10.5 (;)-6.5 (97:)-6.6 (1186)]TJ 0 Tc 0 Tw 32.076 0 Td (-)Tj -0.002 Tc 0.007 Tw -32.076 -1.152 Td [(1194.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw [(h)17.5 (ttp)17.5 (:)0.5 (/)11.2 (/)11.3 (w)9.6 (w)9.6 (w)20.5 (.n)6.6 (c)5 (b)6.7 (i)9.6 (.n)6.7 (l)9.6 (m)1 (.n)6.7 (i)9.6 (h)6.7 (.g)-4.3 (o)]TJ -0.002 Tc 0.002 Tw 20.12 0 Td [(v)8.9 (/)-6.6 (pu)10.5 (bm)-5.9 (ed/)-6.6 (12599224)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 345.84 131.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 117.24 129.6 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 108 Tm [(178.)-6.7 ( S)2 (a)10.5 (m)-5.9 (aan N)2.6 (A)2 (,)4.3 ( S)1.9 (c)-2 (hul)2.6 (t)4.3 (z)8.9 ( P)1.9 (N)2.6 (,)-6.6 ( H)2.6 (ay)8.9 (ni)2.6 (e T)-10.6 (P)2 (,)-6.7 ( )11.3 (O)4.3 (r)-6 (don)10.5 (ez)8.9 ( N)2.6 (G)-6.6 (.)-6.6 ( P)1.9 (ul)2.6 (m)-6 (ona)10.6 (r)-6 (y)8.9 ( )]TJ 0 -1.141 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (i)2.6 (s)-2 ( o)10.5 (f)-6.6 ( di)13.5 (f)-6.6 (f)-6.6 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (at)4.3 (ed t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.5 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (:)-6.6 ( )11.3 (t)-6.6 (r)-6 (e)10.5 (at)-6.6 (m)-6 (en)10.5 (t)-6.6 ( )11.3 (r)-6 (es)-2 (ul)2.6 (t)-6.6 (s)8.9 ( i)2.6 (n )0.5 (101)10.5 ( )]TJ 0 -1.152 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 (.)4.3 ( J)8.8 ( C)2.6 (l)2.7 (i)2.6 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 1985;)-6.6 (60:)-6.6 (376)]TJ 0 Tc 0 Tw 20.391 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(38)10.5 (0.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -20.728 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (3965495)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 70.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 68.04 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(179.)-6.7 ( R)2.7 (ue)10.5 (g)-11.2 (e)10.5 (m)-5.9 (er)5 ( J)-2.1 (J)-1.9 (,)4.2 ( H)2.6 (ay)8.8 ( I)4.3 (D)2.6 (,)-6.6 ( B)2 (er)4.9 (g)-11.2 (s)8.9 (t)-6.6 (r)-6 (al)2.6 (h)10.5 ( E)2 (J)-2 (,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( D)13.5 (i)2.6 (s)-2 (t)-6.6 (ant)-6.6 ( )11.2 (m)-5.9 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (as)-2 (e)10.5 (s)-2 ( i)2.6 (n )]TJ 0 -1.152 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (r)4.9 (c)-2 (i)2.6 (nom)-6 (a:)4.2 ( a )11.2 (m)-5.9 (ul)2.7 (t)-6.7 (i)2.7 (v)8.8 (ar)-6 (i)2.6 (at)-6.6 (e an)10.5 (al)2.6 (y)8.8 (s)-2 (i)2.6 (s)-2 ( of)-17.5 ( p)10.5 (r)-5.9 (o)10.5 (g)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)-2 ( )]TJ 0 -1.141 Td [(v)8.9 (ar)-5.9 (i)2.6 (abl)2.6 (es)-2 (.)-6.6 ( J)-2 ( C)2.6 (l)2.7 (i)2.6 (n E)2 (ndoc)-2 (r)-5.9 (i)13.5 (nol)2.6 ( M)15.8 (et)-6.6 (ab 1988;)-6.6 (67:)-6.6 (501)]TJ 0 Tc 0 Tw 20.88 0 Td (-)Tj -0.013 Tc 0.013 Tw 0.337 0 Td (50)Tj -0.002 Tc 0.007 Tw 1.098 0 Td [(8.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.315 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (3410936)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 473.88 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 452.28 Tm [(180.)-6.7 ( S)2 (a)10.5 (m)-5.9 (aan N)2.6 (A)2 (,)4.2 ( )0.5 (S)1.9 (c)-2 (hul)2.6 (t)4.3 (z)8.9 ( P)1.9 (N)2.6 (,)-6.6 ( H)2.6 (i)2.6 (c)-2 (k)-12.8 (ey)8.9 ( R)2.6 (C)2.6 (,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( )11.3 (The r)-5.9 (es)-2 (ul)2.6 (t)4.2 (s)-2 ( o)10.5 (f)-6.6 ( v)8.9 (ar)-6 (i)2.6 (ous)-2 ( )]TJ 0 -1.141 Td [(m)-6 (odal)2.6 (i)2.6 (t)-6.6 (i)2.6 (es)-2 ( o)10.5 (f)-6.6 ( t)4.2 (r)-5.9 (eat)4.3 (m)-6 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( w)13.5 (el)2.6 (l)2.6 ( di)2.6 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (a)10.5 (t)-6.6 (ed )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-1.9 (i)2.6 (no)10.5 (m)-5.9 (as)-2 (:)4.3 ( )]TJ 0.002 Tw (a )Tj 0.007 Tw 0 -1.152 Td [(r)-6 (et)-6.6 (r)4.9 (os)-2 (pec)-2 (t)-6.6 (i)2.6 (v)8.8 (e r)-6 (ev)8.9 (i)2.6 (ew)13.5 ( of)-17.5 ( 1)10.5 (599 pat)-6.5 (i)2.5 (ent)-6.7 (s)8.9 (.)4.3 ( J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndo)10.5 (c)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.7 (ab )]TJ 0.002 Tw 0 -1.141 Td [(1992;)-6.6 (75:)-6.6 (714)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(720.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (1517360)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 401.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 399.72 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 378 Tm [(181.)-6.7 ( H)2.7 (undahl)2.6 ( S)2 (A)1.9 (,)4.3 ( Fl)2.6 (em)-6 (i)2.6 (n)10.6 (g I)-6.6 (D)2.6 (,)4.3 ( Fr)-6 (e)10.5 (m)4.9 (g)-11.2 (en)10.5 ( A)2 (M)15.8 (,)-6.7 ( M)15.8 (en)-11.3 (c)-1.9 (k)-2 ( H)2.6 (R)2.6 (.)4.2 ( A)2 ( N)2.6 (at)-6.6 (i)]TJ 0.002 Tw 27.696 0 Td [(onal)2.6 ( )]TJ 0.007 Tw -27.696 -1.141 Td [(C)2.6 (anc)-2 (er)-6 ( D)2.6 (at)-6.6 (a)10.5 ( B)1.9 (as)-2 (e )11.2 (r)-5.9 (epor)4.9 (t)4.3 ( on 53)10.5 (,)-6.6 (856 c)-2 (a)10.5 (s)-2 (es)-2 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (hy)8.9 (r)4.9 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( t)4.3 (r)-6 (eat)-6.6 (ed)10.5 ( i)2.6 (n )]TJ 0 -1.141 Td [(t)-6.6 (he U)2.6 (.)-6.6 (S)12.8 (.)-6.6 (,)4.3 ( 1985)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 6.717 0 Td [(1995)10.5 ( )11.2 ([)-6.6 (s)-2 (ee)10.5 ( c)-2 (om)4.9 (m)-6 (en)10.5 (t)-6.6 (s)-2 (])4.3 (.)-6.7 ( C)2.7 (anc)-2 (e)10.5 (r)-6 ( 199)10.6 (8;)-6.6 (83:)-6.6 (2638)]TJ 0 Tc 0 Tw 19.652 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(2648.)4.3 ( )]TJ 0.007 Tw -26.707 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (9874472)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 690.6 340.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 338.04 222.48 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 316.44 Tm [(182.)-6.7 ( B)2 (audi)2.6 (n E)12.9 (,)-6.7 ( )11.3 (Tr)-5.9 (av)8.9 (ag)-11.2 (l)2.6 (i)2.7 ( )11.2 (J)-2 (P)2 (,)-6.7 ( R)2.7 (oper)4.9 (s)-2 ( J)8.9 (,)-6.6 ( e)10.5 (t)-6.6 ( al)13.4 (.)-6.6 ( M)15.8 (i)2.6 (c)-2 (r)-5.9 (oc)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.5 ( t)-6.6 (hy)8.9 (r)-6 (oi)13.5 (d )]TJ -0.004 Tw 0 -1.141 Td [(g)-11.2 (l)2.6 (and:)4.2 ( )-10.6 (t)-6.6 (he)10.6 ( G)-6.7 (us)-2 (t)-6.6 (av)8.9 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 8.707 0 Td [(R)2.6 (ous)8.9 (s)-2 (y)8.9 ( I)-6.7 (ns)-2 (t)-6.6 (i)2.6 (t)-6.6 (u)10.5 (t)-6.6 (e ex)8.9 (per)-6 (i)2.6 (enc)-2 (e.)4.3 ( )11.2 (C)2.6 (anc)-2.1 (er)-6 ( 1998)10.5 (;)-6.6 (83:)-6.6 (553)]TJ 0 Tc 0 Tw 21.815 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(559)10.5 (.)-6.6 ( )]TJ 0.007 Tw -30.859 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (9)]TJ (690549)Tj EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 690.6 291.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 289.08 222.48 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 267.48 Tm [(183.)-6.7 ( R)2.7 (ot)-6.6 (i)13.5 ( E)1.9 (,)4.3 ( de)10.6 (g)-11.2 (l)2.6 (i)2.6 ( U)2.6 (ber)-6 (t)-6.6 (i)2.6 ( )11.3 (E)2 (C)2.6 (,)-6.6 ( B)1.9 (ondanel)2.6 (l)2.7 (i)2.6 ( M)15.7 (,)-6.6 ( B)2 (r)-6 (av)8.9 (e)-11.3 (r)-5.9 (m)-6 (an)10.5 ( LE)2 (.)4.3 ( )11.2 (T)-10.5 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.141 Td [(papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( m)-6 (i)2.6 (c)-2 (r)-5.9 (oc)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (:)-6.6 ( a)10.5 ( des)-2 (c)-2 (r)-5.9 (i)2.6 (p)10.5 (t)-6.6 (i)2.6 (v)8.9 (e and m)-6 (e)10.5 (t)-6.6 (a)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 21.935 0 Td [(anal)2.6 (y)8.9 (s)-2.1 (i)2.7 (s)-2.1 ( )0.5 (s)-2.1 (t)-6.5 (udy)8.9 (.)-6.6 ( E)2 (ur)-5.9 ( J)8.8 ( )]TJ -21.935 -1.152 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( 2008;)-6.6 (159)10.5 (:)-6.6 (659)]TJ 0 Tc 0 Tw 11.076 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(673.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -11.413 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)]TJ -0.002 Tc 0.002 Tw 3.217 0 Td [(w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.7 (m)-6 (.)-6.6 (ni)2.7 (h.)4.3 (gov)8.9 (/)-6.7 (pubm)-6 (ed/)-6.6 (18713843)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 229.56 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 227.52 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 205.92 Tm [(184.)-6.7 ( M)15.8 (az)-2 (z)8.8 (af)-17.5 (er)4.9 (r)-6 (i)2.7 ( E)1.9 (L.)4.2 ( M)15.8 (an)-11.3 (ag)-11.2 (e)10.5 (m)-5.9 (ent)4.2 ( o)10.5 (f)-6.6 ( l)2.6 (ow)]TJ 0 Tc 0 Tw 17.609 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(r)-6 (i)2.7 (s)-2 (k)-2 ( di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (an)10.6 (c)-2.1 (er)4.9 (.)-6.6 ( )]TJ -17.946 -1.141 Td [(E)2 (ndoc)-2 (r)-5.9 ( P)1.9 (r)-5.9 (a)10.5 (c)-2 (t)4.2 ( 2007;)-6.7 (13)10.5 (:)-6.6 (49)10.5 (8)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 11.913 0 Td [(512.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -11.913 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (178723)]TJ (53)Tj EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 180.6 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 178.56 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 156.96 Tm [(185.)-6.7 ( S)2 (u)10.5 (g)-11.2 (i)2.6 (no K)12.9 (,)-6.7 ( )11.3 (I)-6.6 (t)-6.6 (o)10.5 ( K)2 (,)4.2 ( J)-2 (r)4.9 (.)-6.6 (,)4.3 ( )11.3 (O)-6.6 (z)8.8 (ak)-12.9 (i)2.6 ( )11.3 (O)-6.6 (,)4.2 ( et)4.2 ( )0.5 (al)2.6 (.)4.3 ( P)1.9 (api)2.6 (l)2.7 (l)2.6 (ar)-5.9 (y)8.8 ( m)-5.9 (i)2.6 (c)-2 (r)-6 (oc)-2 (a)10.5 (r)-6 (c)-2 (i)2.7 (nom)-6 (a)10.5 ( o)10.6 (f)-6.7 ( )0.5 (t)-6.7 (he)10.5 ( )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d.)-6.6 ( J)8.8 ( E)2 (ndoc)-1.9 (r)-6 (i)2.6 (nol)2.6 ( I)4.3 (nv)8.9 (es)-2 (t)-6.7 ( )0.5 (1998)10.5 (;)-6.6 (21:)-6.6 (445)]TJ 0 Tc 0 Tw 17.783 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(448.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -18.12 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9766259)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 131.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 129.6 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 108 Tm [(186.)-6.7 ( H)2.7 (ay)8.9 ( I)-6.6 (D)2.6 (.)4.2 ( P)]TJ 6.489 0 Td [(api)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d c)-1.9 (ar)-6 (c)-2 (i)2.6 (nom)-6 (a.)4.2 ( E)2 (ndoc)8.9 (r)-6 (i)2.7 (nol)2.6 ( M)15.8 (et)-6.6 (ab C)2.6 (l)2.6 (i)2.6 (n N)2.6 (or)-5.9 (t)-6.6 (h A)2 (m)4.9 ( )]TJ 0.002 Tw -6.489 -1.141 Td [(1990;)-6.6 (19:)-6.6 (545)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(576.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (2261906)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 82.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 80.64 222.6 0.84 re f EMC endstream endobj 982 0 obj 26681 endobj %% Contents for page 113 %% Original object ID: 227 0 983 0 obj << /Length 984 0 R >> stream Q q BT /Xi111 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 984 0 obj 246 endobj %% Original object ID: 11655 0 985 0 obj [ 2840 0 R 2841 0 R 2842 0 R 2843 0 R 2844 0 R 2845 0 R 2846 0 R 2847 0 R 2848 0 R 2849 0 R 2850 0 R 2851 0 R 2852 0 R ] endobj %% Contents for page 114 %% Original object ID: 228 0 986 0 obj << /Length 987 0 R >> stream q endstream endobj 987 0 obj 2 endobj %% Contents for page 114 %% Original object ID: 11656 0 988 0 obj << /Length 989 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (51)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(187.)-6.7 ( E)12.9 (m)-6 (er)-6 (i)2.6 (c)8.9 (k)-2 ( G)4.2 (T,)-6.6 ( D)2.7 (uh)10.5 ( Q)4.3 (Y)1.9 (,)-6.6 ( )0.5 (S)1.9 (i)2.6 (per)-5.9 (s)8.8 (t)-6.6 (ei)2.6 (n A)2 (E)2 (,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( D)13.5 (i)2.6 (ag)-11.2 (nos)-2 (i)2.6 (s)-2 (,)4.3 ( t)4.2 (r)-5.9 (eat)]TJ 28.087 0 Td [(m)-6 (ent)4.3 (,)4.3 ( and )]TJ -28.087 -1.152 Td [(out)-6.6 (c)-2 (om)-6 (e)10.5 ( o)10.5 (f)-6.6 ( )11.3 (f)-6.6 (ol)2.7 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( C)2.6 (anc)-2 (e)10.5 (r)-5.9 ( 1)10.5 (993;)-6.6 (72:)-6.6 (3287)]TJ 0 Tc 0 Tw 27.152 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(3295.)4.3 ( )]TJ 0.007 Tw -27.489 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (8080485)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 309.12 488.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 486.6 222.48 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 465 Tm [(188.)-6.7 ( S)2 (al)2.6 (v)8.8 (es)-2 (en H)2.6 (,)-6.6 ( N)13.5 (j)-8.3 (ol)2.6 (s)-2 (t)-6.6 (a)10.5 (d P)2 (R)2.6 (,)-6.6 ( A)12.8 (k)-12.9 (s)-1.9 (l)2.6 (en)10.6 ( LA)2 (,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( P)12.8 (api)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)]TJ 0.002 Tw 26.913 0 Td [(oi)2.6 (d )]TJ 0.007 Tw -26.913 -1.152 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (:)-6.6 ( a)10.5 ( m)-6 (ul)13.5 (t)-6.6 (i)2.6 (v)8.8 (ar)-6 (i)2.7 (at)-6.6 (e anal)2.6 (y)8.9 (s)-2 (i)2.6 (s)-2 ( of)-6.6 ( pr)-6 (o)10.6 (g)-11.3 (no)10.5 (s)-2 (t)-6.6 (i)2.6 (c)8.9 ( )11.3 (f)-17.5 (a)10.5 (c)-2 (t)-6.6 (or)-5.9 (s)8.9 ( i)2.6 (nc)-2 (l)2.6 (udi)2.6 (ng an )]TJ 0 -1.141 Td [(ev)8.8 (al)2.6 (uat)-6.6 (i)2.6 (on of)-6.5 ( t)-6.6 (he)10.5 ( p)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 8.478 0 Td [(T)-10.6 (N)2.6 (M)15.8 ( s)-2 (t)-6.6 (a)10.5 (g)-11.2 (i)2.6 (ng s)-2 (y)8.9 (s)-2 (t)-6.6 (e)10.5 (m)-5.9 (.)4.2 ( E)2 (ur)5 ( J)-2 ( )0.5 (S)1.9 (u)10.5 (r)-5.9 (g 1992)10.5 (;)-6.6 (158:)-6.7 (583)]TJ 0 Tc 0 Tw 20.717 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(589.)4.2 ( )]TJ 0.007 Tw -29.533 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (13630)]TJ (62)Tj EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 309.12 426.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 424.92 222.48 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 403.32 Tm [(189.)-6.7 ( P)2 (i)2.6 (n)10.5 (g)-11.2 (pan)10.5 (k)-12.8 ( )11.3 (J)-2 (F,)4.2 ( J)-2 (r)4.9 (.)-6.6 (,)4.3 ( S)12.8 (as)-2 (s)-2 (on A)1.9 (R)2.6 (,)4.3 ( H)2.6 (anl)2.6 (on A)2 (L,)4.3 ( et)4.3 ( al)2.7 (.)-6.6 ( )11.2 (T)-10.5 (u)10.5 (m)-6 (or)4.9 ( abov)8.8 (e t)-6.6 (he)10.5 ( )]TJ 0 -1.141 Td [(s)-2 (pi)2.6 (nal)2.6 ( ac)-2 (c)-2 (es)-2 (s)-2 (or)-5.9 (y)8.8 ( )0.5 (ner)-6 (v)8.9 (e i)13.5 (n papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 ( t)-6.7 (ha)10.5 (t)-6.6 ( i)2.6 (nv)8.8 (ol)2.6 (v)8.9 (es)-2 ( l)2.6 (at)-6.6 (er)-5.9 (al)2.6 ( nec)8.9 (k)-2 ( )]TJ 0 -1.152 Td [(nodes)-2 (:)-6.6 ( a)10.5 ( c)-2 (o)10.6 (m)-6 (m)-6 (on)10.5 ( oc)-2 (c)-2 (u)10.5 (r)-6 (r)5 (enc)-2 (e.)-6.6 ( A)12.8 (r)-5.9 (c)-2 (h )11.3 (O)4.3 (t)-6.7 (ol)2.6 (ar)-5.9 (y)8.9 (ng)-11.2 (ol)2.6 ( )11.2 (H)2.6 (ead N)2.6 (ec)8.8 (k)-12.8 ( S)1.9 (ur)4.9 (g )]TJ 0.002 Tw 0 -1.141 Td [(2002;)-6.6 (128:)-6.6 (1275)]TJ 0 Tc 0 Tw 6.652 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1278.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.989 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (12431169)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 350.76 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 329.16 Tm [(190.)-6.7 ( P)2 (odnos)8.9 ( Y)1.9 (D)2.7 (,)-6.7 ( S)12.9 (m)-6 (i)2.6 (t)-6.6 (h)10.5 ( )11.3 (D)2.6 (,)-6.6 ( )22.1 (W)-36.2 (a)10.5 (gm)4.9 (an)10.6 ( LD)2.6 (,)-6.6 ( E)2 (l)2.6 (l)2.6 (enhor)4.9 (n J)-2.1 (D)2.7 (.)4.2 ( )11.3 (T)-10.6 (he i)2.6 (m)-5.9 (pl)2.6 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (on)10.5 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.152 Td [(l)2.6 (y)8.9 (m)-6 (ph node m)-5.9 (e)10.5 (t)-6.6 (as)-1.9 (t)-6.7 (a)10.6 (s)-2 (i)2.6 (s)-2 ( o)10.5 (n s)-2 (ur)-6 (v)8.9 (i)2.6 (v)8.9 (al)2.6 ( i)2.6 (n pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h w)13.4 (el)2.6 (l)]TJ 0 Tc 0 Tw 24.076 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(di)2.6 (f)-6.6 (f)-17.5 (er)-5.9 (en)10.6 (t)-6.7 (i)2.7 (at)-6.6 (ed)10.6 ( )]TJ 0.007 Tw -24.413 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 (.)-6.7 ( A)12.9 (m)-6 ( S)2 (u)10.5 (r)4.9 (g)]TJ 0 Tc 0 Tw 10.696 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.272 0 Td [(2005;)-6.6 (71:)-6.6 (731)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(734.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -16.848 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (16468507)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 291.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 289.08 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 267.48 Tm [(191.)-6.7 ( Zay)8.9 (d)10.5 (f)-17.5 (udi)2.6 (m)5 ( V)1.9 (,)4.3 ( Feur)-6 (e)10.6 (r)-6 ( )11.2 (I)-6.6 (D)2.6 (,)-6.6 ( )11.3 (G)4.3 (r)-6 (i)13.5 (f)-6.6 (f)-17.5 (i)2.6 (n M)15.8 (R)2.6 (,)-6.6 ( P)1.9 (hay)8.9 ( J)-2 (E)12.8 (.)-6.6 ( )11.3 (T)-10.6 (he)10.5 ( i)2.6 (m)-6 (pac)8.9 (t)-6.6 ( o)10.5 (f)-6.6 ( l)2.6 (y)8.9 (m)-6 (ph )]TJ 0 -1.141 Td [(node i)2.6 (nv)8.8 (ol)-8.3 (v)8.9 (em)-6 (ent)-6.6 ( on)10.5 ( s)-2 (ur)4.9 (v)8.9 (i)-8.3 (v)8.9 (al)2.6 ( i)2.6 (n pat)-6.7 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h pap)]TJ [(i)2.6 (l)2.7 (l)2.6 (ar)-5.9 (y)8.8 ( and )11.3 (f)-17.5 (ol)2.6 (l)2.6 (i)2.7 (c)-2 (ul)2.6 (ar)-6 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( S)1.9 (u)10.5 (r)5 (g)-11.2 (er)-6 (y)8.9 ( 200)10.5 (8;)-6.6 (144:)-6.6 (1070)]TJ 0 Tc 0 Tw 15.565 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1077;)4.3 ( di)2.6 (s)-2 (c)-2 (us)8.9 (s)-2 (i)2.6 (on 1077)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 10.25 0 Td [(1078.)4.3 ( )]TJ 0.007 Tw -26.152 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (19041020)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 229.56 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 227.52 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 205.92 Tm [(192.)-6.7 ( R)2.7 (andol)2.6 (ph )11.3 (G)15.1 (W)-25.4 (,)4.3 ( D)2.7 (uh)10.5 ( Q)-6.6 (Y)12.8 (,)-6.6 ( )0.5 (H)2.5 (el)2.6 (l)2.6 (er)-6 ( K)2 (S)1.9 (,)4.3 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( )11.3 (T)-10.6 (h)]TJ 21.489 0 Td [(e pr)-5.9 (o)10.5 (g)-11.2 (nos)8.8 (t)-6.6 (i)2.6 (c)-2 ( s)-2 (i)13.5 (g)-11.2 (ni)13.5 (f)-17.5 (i)2.7 (c)-2 (anc)-2 (e)10.5 ( )]TJ -21.489 -1.141 Td [(o)10.5 (f)-17.5 ( nodal)2.7 ( )11.2 (m)-5.9 (et)-6.6 (a)10.5 (s)-2 (t)-6.6 (as)-2 (e)10.5 (s)-2 ( )11.3 (f)-6.6 (r)-6 (o)10.5 (m)-5.9 ( papi)2.5 (l)2.7 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (d c)-2 (ar)-6 (c)-2 (i)2.6 (n)10.5 (om)-6 (a c)-2 (an)10.5 ( be )11.2 (s)-2 (t)4.3 (r)-6 (at)-6.6 (i)13.5 (f)-17.5 (i)2.6 (ed)10.6 ( )]TJ 0 -1.152 Td [(bas)-2 (ed on )11.3 (t)-6.6 (he )11.3 (s)-2 (i)2.6 (z)8.8 (e and n)10.5 (um)-5.9 (ber)4.9 ( o)10.5 (f)-6.6 ( m)-6 (e)10.6 (t)-6.7 (as)8.9 (t)-6.6 (at)-6.6 (i)2.6 (c)8.9 ( l)2.6 (y)8.9 (m)-6 (ph nodes)-2 (,)4.3 ( as)8.9 ( w)13.5 (el)2.6 (l)2.6 ( )0.5 (as)-2 ( t)-6.6 (he )]TJ 0 -1.141 Td [(pr)-6 (es)-2 (enc)-2 (e o)10.5 (f)-6.6 ( ex)8.8 (t)4.3 (r)-5.9 (anodal)2.6 ( e)10.6 (x)8.8 (t)-6.6 (ens)-2 (i)2.6 (on.)-6.6 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d 2012;)-6.6 (2)10.5 (2:)-6.6 (1144)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 25.272 0 Td [(1152)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e )]TJ -0.006 Tc 0.006 Tw -25.272 -1.152 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.7 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (23083442)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 267.48 155.28 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 38.88 153.24 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 131.64 Tm [(193.)-6.7 ( B)2 (enbas)-2 (s)-2 (a)10.6 (t)-6.7 ( C)2.7 (A)12.8 (,)-6.6 ( M)15.7 (ec)-2 (hl)2.7 (i)2.6 (s)]TJ 0 Tc 0 Tw 12.511 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(Fr)-6 (i)2.7 (s)-2 (h S)2 (,)4.2 ( H)2.6 (i)2.7 (r)-6 (s)-2 (c)-2 (h D)13.5 (.)-6.6 ( C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (opat)-6.6 (hol)2.6 (og)-11.2 (i)2.6 (c)-2 (al)2.6 ( )]TJ -12.848 -1.141 Td [(c)-2 (har)-6 (ac)-2 (t)-6.6 (e)10.5 (r)-5.9 (i)2.6 (s)-2 (t)-6.6 (i)2.6 (c)-2 (s)8.8 ( and l)2.6 (on)10.5 (g)]TJ 0 Tc 0 Tw 10.478 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(t)4.3 (er)-5.9 (m)4.9 ( out)-6.6 (c)-2 (o)10.5 (m)-6 (e)10.6 ( i)2.6 (n pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 (s)-2 ( )11.3 (w)2.6 (i)2.6 (t)-6.6 (h di)2.6 (s)-2 (t)-6.6 (ant)4.2 ( )11.3 (m)-5.9 (et)-6.6 (as)8.8 (t)-6.6 (as)-2 (es)8.9 ( )]TJ -10.804 -1.152 Td [(f)-6.6 (r)-6 (o)10.6 (m)-6 ( di)13.5 (f)-6.6 (f)-6.6 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( t)-6.6 (hy)8.8 (r)]TJ 9.978 0 Td [(oi)13.4 (d c)-2 (anc)-2 (er)5 (.)-6.7 ( )33 (W)-36.2 (o)10.5 (r)-5.9 (l)2.6 (d)10.5 ( J)-2 ( S)2 (u)10.5 (r)4.9 (g)-11.2 ( 2)10.5 (006;)-6.6 (30:)-6.6 (1088)]TJ 0 Tc 0 Tw 17.272 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(1095.)4.3 ( )]TJ 0.007 Tw -27.587 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (16736341)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 93.72 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 91.68 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 70.08 Tm [(194.)-6.7 ( S)2 (a)10.5 (m)-5.9 (ps)-2 (on E)12.8 (,)-6.5 ( B)12.8 (r)-6 (i)2.6 (er)-6 (l)2.6 (ey)8.9 ( J)-2 (D)2.7 (,)-6.6 ( Le L)32.2 (W)-36.2 (,)4.2 ( )11.3 (et)4.3 ( al)2.7 (.)4.2 ( C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-12.9 (al)2.6 ( m)-5.9 (ana)10.5 (g)-11.2 (e)10.5 (m)-6 (ent)4.3 ( and )]TJ 0 -1.141 Td [(out)-6.6 (c)-2 (om)-6 (e)10.5 ( o)10.5 (f)-6.6 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( and )11.3 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( \()-6 (di)13.5 (f)-6.7 (f)-6.6 (er)-6 (e)10.6 (nt)-6.6 (i)2.6 (at)-6.7 (ed)10.5 (\))-5.9 ( )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 ( )]TJ 34.554 41.348 Td [(pr)-6 (es)-2 (ent)-6.7 (i)2.7 (n)10.5 (g)-11.2 ( w)13.4 (i)2.7 (t)-6.7 (h di)2.7 (s)-2 (t)-6.7 (an)10.5 (t)-6.6 ( )11.3 (m)4.9 (et)-6.6 (as)-2 (t)-6.6 (as)-2.1 (i)2.7 (s)8.8 ( at)4.2 ( di)2.6 (a)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)-2 (.)4.3 ( C)2.6 (anc)-2 (er)-5.9 ( 2007)10.6 (;)-6.6 (110:)-6.6 (1451)]TJ 0 Tc 0 Tw 31.25 0 Td (-)Tj -0.002 Tc 0.007 Tw -31.25 -1.152 Td [(1456.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.3 (/)4.3 (w)2.6 (w)2.6 (w)13.4 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.7 (nl)2.6 (m)-5.9 (.)-6.7 (ni)2.6 (h.)-6.6 (g)-11.3 (ov)8.9 (/)-6.7 (pu)10.5 (bm)-6 (ed/)-6.6 (17705176)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 727.32 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 498.72 499.2 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 477.6 Tm [(195.)-6.7 ( S)2 (c)-2 (hl)2.6 (um)-5.9 (be)10.6 (r)4.9 (g)-11.3 (er)4.9 ( M)15.8 (,)-6.6 ( C)2.6 (hal)2.6 (l)2.6 (et)-6.6 (on C)2.6 (,)-6.6 ( D)2.6 (e)10.5 ( V)1.9 (at)-6.6 (hai)2.6 (r)-5.9 (e)10.5 ( )11.3 (F,)-6.7 ( P)2 (ar)5 (m)-6 (en)10.5 (t)-6.6 (i)2.6 (er)-5.9 ( C)13.5 (.)-6.7 ( )]TJ 0 -1.141 Td [(T)-10.6 (r)-5.9 (e)10.5 (at)4.3 (m)-5.9 (ent)4.2 ( o)10.5 (f)-6.5 ( di)2.6 (s)-2 (t)-6.6 (an)10.6 (t)-6.6 ( )11.2 (m)-5.9 (et)4.3 (as)-1.9 (t)-6.7 (as)-2 (es)8.9 ( o)10.5 (f)-6.6 ( di)13.4 (f)-6.6 (f)-17.4 (e)10.5 (r)-6 (ent)-6.6 (i)2.6 (a)10.6 (t)-6.6 (ed )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)4.9 (a.)4.2 ( )0.5 (J)-2.1 ( )]TJ 0 -1.152 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( I)-6.6 (nv)8.9 (es)-1.9 (t)-6.7 ( 1995)10.5 (;)-6.6 (1)10.5 (8:)-6.6 (170)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.804 0 Td [(172)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)]TJ 0 Tc 0 Tw 7.641 0 Td ( )Tj EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw -21.446 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (7629392)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 439.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 437.64 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 416.04 Tm [(196.)-6.7 ( S)2 (i)2.6 (s)-2 (s)-2 (on )11.3 (J)-2 (C)2.6 (,)-6.6 ( )11.3 (G)-6.7 (i)2.7 (or)-5.9 (dan)10.5 (o )11.3 (T)-10.6 (J)-2 (,)4.3 ( J)-2 (a)10.5 (m)-5.9 (adar)5 ( D)2.6 (A)2 (,)-6.6 ( e)10.5 (t)-6.6 ( al)13.4 (.)-6.6 ( )11.3 (131)]TJ 0 Tc 0 Tw (-)Tj -0.006 Tc 0.011 Tw 23.826 0 Td [(I tr)-9.9 (e)-4.4 (a)-4.3 (tm)-9.9 (e)-4.4 (n)-4.3 (t o)6.5 (f)-10.6 ( )]TJ -0.002 Tc 0.007 Tw -23.826 -1.152 Td [(m)-6 (i)2.7 (c)-2 (r)-6 (onodul)2.6 (ar)4.9 ( pul)2.7 (m)-6 (onar)-6 (y)8.9 ( )11.2 (m)-5.9 (et)-6.6 (as)8.9 (t)-6.7 (as)-2 (es)8.9 ( )11.3 (f)-6.6 (r)-6 (om)4.9 ( papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( )]TJ 0 -1.141 Td [(C)2.6 (anc)-2 (er)-6 ( 1996)10.5 (;)-6.6 (78:)-6.6 (2184)]TJ 0 Tc 0 Tw 9.587 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(21)10.5 (92.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -9.924 -1.152 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)6.6 (l)9.6 (m)1.1 (.n)6.6 (i)]TJ -0.002 Tc 0.002 Tw 9.696 0 Td [(h.)4.2 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8918413)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 378 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 375.96 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 354.36 Tm [(197.)-6.7 ( S)2 (c)-2 (hl)2.6 (um)-5.9 (be)10.6 (r)4.9 (g)-11.3 (er)4.9 ( M)15.8 (,)-6.6 ( C)2.6 (hal)2.6 (l)2.6 (et)-6.6 (on C)2.6 (,)-6.6 ( D)2.6 (e)10.5 ( V)1.9 (at)-6.6 (hai)2.6 (r)-5.9 (e)10.5 ( )11.3 (F,)-6.7 ( e)10.6 (t)-6.6 ( al)2.6 (.)4.3 ( R)2.6 (adi)2.6 (oac)-2 (t)-6.6 (i)2.6 (v)8.9 (e )]TJ 0 -1.141 Td [(i)2.6 (odi)2.6 (ne t)-6.6 (r)-5.9 (eat)4.2 (m)-5.9 (en)10.5 (t)-6.5 ( and)10.6 ( ex)8.9 (t)-6.6 (er)-5.9 (nal)2.6 ( r)-6 (adi)2.7 (ot)-6.6 (he)10.5 (r)-6 (apy)8.9 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( l)2.7 (un)10.5 (g and bone)10.5 ( m)-5.9 (e)10.5 (t)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)-2 ( )]TJ 0 -1.141 Td [(f)-6.6 (r)-6 (o)10.6 (m)-6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-1.9 (i)2.5 (no)10.5 (m)-5.9 (a.)4.3 ( )11.3 (J)-2 ( N)2.7 (uc)-2 (l)2.6 ( M)15.8 (ed 1996;)-6.6 (37:)-6.6 (598)]TJ 0 Tc 0 Tw 21.489 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(605.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -21.826 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8691248)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 316.44 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 314.4 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 292.8 Tm [(198.)-6.7 ( B)2 (r)-6 (ow)13.5 (n A)2 (P)1.9 (,)4.3 ( G)4.3 (r)-6 (eeni)2.6 (ng )22.1 (W)-36.2 (P)12.8 (,)4.3 ( M)15.8 (c)-2 (C)2.6 (r)-5.9 (eady)8.8 ( V)2 (R)2.6 (,)-6.6 ( et)4.3 ( )11.3 (al)2.6 (.)-6.6 ( R)2.6 (adi)2.6 (oi)2.6 (odi)2.6 (ne t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)4.3 ( )]TJ 0 -1.141 Td [(o)10.5 (f)-17.5 ( )11.3 (m)-5.9 (et)-6.6 (as)8.9 (t)-6.6 (a)10.5 (t)-6.6 (i)2.7 (c)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.5 (r)-5.9 (c)8.9 (i)2.6 (nom)-6 (a:)-6.6 ( )11.2 (t)-6.6 (he R)2.6 (oy)8.9 (al)2.6 ( M)15.8 (ar)-5.9 (s)-2 (den H)2.6 (os)-2 (pi)2.6 (t)-6.6 (al)2.6 ( ex)8.9 (per)-6 (i)2.6 (enc)-2 (e.)-6.6 ( )]TJ 0 -1.152 Td [(B)2 (r)-6 ( J)8.9 ( R)2.6 (adi)2.6 (ol)2.7 ( 1984;)-6.7 (57:)-6.7 (323)]TJ 0 Tc 0 Tw 10.696 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(327.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.7 (abl)2.6 (e )]TJ 0.005 Tc -0.005 Tw [(a)6.7 (t: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw -11.022 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (6704664)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 254.88 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 252.84 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 231.24 Tm [(199.)-6.7 ( C)2.7 (as)-2 (a)10.5 (r)-5.9 (a D)2.6 (,)4.3 ( R)2.6 (ubel)2.6 (l)2.6 (o )11.2 (D)2.6 (,)-6.6 ( S)2 (al)2.6 (adi)2.6 (ni)2.6 ( G)-6.6 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( D)2.6 (i)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)4.2 ( )11.3 (f)-17.5 (ea)10.5 (t)-6.6 (ur)-5.9 (es)8.9 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.152 Td [(pul)2.6 (m)-5.9 (onar)-5.9 (y)8.8 ( m)-5.9 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (a)10.6 (s)-2 (es)-2 ( i)2.6 (n)10.6 ( di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-6 (ent)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.5 (nc)-2 (er)-6 (:)4.3 ( nat)-6.6 (u)10.5 (r)-6 (al)2.6 ( hi)2.6 (s)-2 (t)-6.6 (o)10.6 (r)-6 (y)8.9 ( and )]TJ -0.005 Tc 0.005 Tw 0 -1.141 Td [(m)-9 (u)-3.3 (lt)-9.6 (iv)5.8 (a)]TJ -0.002 Tc 0.007 Tw 3.152 0 Td [(r)-6 (i)2.7 (at)-6.6 (e s)8.8 (t)-6.6 (at)-6.7 (i)2.7 (s)-2 (t)-6.6 (i)2.6 (c)-2 (al)2.6 ( an)10.5 (al)2.6 (y)8.8 (s)-2 (i)2.7 (s)-2 ( of)-17.5 ( p)10.5 (r)-5.9 (o)10.5 (g)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)-2 ( v)8.8 (ar)-6 (i)2.6 (abl)2.6 (es)-2 (.)-6.6 ( J)8.9 ( N)2.6 (uc)-2 (l)2.6 ( )0.5 (M)15.7 (ed )]TJ 0.002 Tw -3.152 -1.141 Td [(1993;)-6.6 (34:)-6.6 (1626)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1631.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8410272)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 180.6 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 178.56 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 156.96 Tm [(200.)-6.7 ( Fl)2.6 (em)-5.9 (i)2.6 (n)10.5 (g I)-6.6 (D)2.6 (,)4.3 ( C)2.6 (ooper)4.9 ( J)-2 (S)2 (,)4.2 ( H)2.7 (ens)-2 (on D)2.6 (E)1.9 (.)4.3 ( A)2 (J)-2 (C)2.6 (C)2.6 ( )11.3 (C)2.6 (anc)-2 (er)-5.9 ( S)1.9 (t)-6.6 (a)10.5 (g)-11.2 (i)2.6 (n)]TJ 27.696 0 Td [(g M)15.8 (anual)2.7 (,)-6.7 ( )]TJ -27.696 -1.141 Td [(5t)-6.7 (h ed)10.6 (.)-6.6 ( P)1.9 (hi)2.6 (l)2.6 (adel)2.7 (phi)2.6 (a:)-6.6 ( Li)2.6 (ppi)2.6 (nc)-2.1 (ot)-6.6 (t)-6.6 ( )33 (W)-36.3 (i)2.6 (l)2.6 (l)2.7 (i)2.6 (am)-5.9 (s)8.8 ( )0.5 (&)1.9 ( )33 (W)-36.3 (i)2.6 (l)13.5 (k)-12.8 (i)2.6 (n)10.5 (s)-2 (;)-6.6 ( 1997)10.6 (.)]TJ 0 Tc 0 Tw 24.978 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -24.978 -2.141 Td [(201.)-6.7 ( )11.3 (G)-6.6 (r)-5.9 (eene)10.5 ( FL,)4.2 ( P)2 (a)10.5 (g)-11.2 (e D)13.4 (L,)-6.6 ( Fl)2.6 (em)-6 (i)2.6 (n)10.5 (g I)-6.6 (D)2.6 (.)4.2 ( A)2 (J)-2 (C)2.6 (C)2.6 ( C)2.6 (a)10.6 (nc)-2 (er)-6 ( S)12.8 (t)-6.6 (a)10.5 (g)-11.2 (i)2.6 (ng M)15.8 (anual)2.6 (,)-6.6 ( 6t)-6.6 (h)10.5 ( )]TJ 0 -1.152 Td [(ed.)-6.6 ( N)2.6 (ew)13.4 ( Y)2 (or)5 (k)-12.9 (:)4.2 ( S)2 (pr)-6 (i)2.6 (n)10.5 (g)-11.2 (er)]TJ 0 Tc 0 Tw 10.304 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(V)2 (er)-5.9 (l)2.6 (ag;)-6.6 ( 2002)10.5 (.)]TJ 0 Tc 0 Tw 5.924 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -16.554 -2.141 Td [(202.)-6.7 ( E)2 (d)10.5 (g)-11.2 (e)10.5 ( S)2 (B)1.9 (,)-6.6 ( B)2 (y)8.9 (r)-6 (d D)2.6 (R)2.6 (,)4.2 ( )11.3 (C)2.6 (om)-6 (pt)-6.6 (on)10.5 ( C)2.6 (C)2.7 (,)-6.7 ( e)10.6 (t)-6.7 ( al)2.6 (.)4.3 ( A)1.9 (J)-2 (C)13.5 (C)2.6 ( C)2.6 (anc)-2 (er)-6 ( S)12.9 (t)-6.7 (a)10.6 (g)-11.2 (i)2.6 (ng )]TJ 0 -1.141 Td [(M)15.8 (anua)-11.2 (l)2.6 (,)-6.6 ( 7t)-6.6 (h e)10.5 (d.)4.2 ( )0.5 (N)2.6 (ew)]TJ 0 Tc 0 Tw 9.13 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(Y)2 (or)-5.9 (k)-2.1 (:)-6.5 ( S)2 (p)10.5 (r)-5.9 (i)2.6 (ng)-11.2 (e)10.5 (r)-5.9 (;)4.2 ( 2010:)-6.7 (1)]TJ 0 Tc 0 Tw 9.978 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td (646.)Tj 0 Tc 0 Tw 1.935 0 Td ( )Tj EMC ET endstream endobj 989 0 obj 26821 endobj %% Contents for page 114 %% Original object ID: 229 0 990 0 obj << /Length 991 0 R >> stream Q q BT /Xi112 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 991 0 obj 246 endobj %% Original object ID: 11670 0 992 0 obj [ 2853 0 R 2854 0 R 2855 0 R 2856 0 R 2857 0 R 2858 0 R 2859 0 R 2860 0 R 2861 0 R 2862 0 R 2863 0 R 2864 0 R 2865 0 R 2866 0 R 2867 0 R ] endobj %% Contents for page 115 %% Original object ID: 230 0 993 0 obj << /Length 994 0 R >> stream q endstream endobj 994 0 obj 2 endobj %% Contents for page 115 %% Original object ID: 11671 0 995 0 obj << /Length 996 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (52)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(203.)-6.7 ( C)2.7 (ady)8.8 ( B)2 (.)4.2 ( H)2.7 (ay)8.9 (es)-2 ( M)15.8 (ar)-16.9 (t)-6.6 (i)2.6 (n Lec)-2 (t)-6.6 (u)10.5 (r)-5.9 (e.)4.3 ( )11.2 (O)-6.6 (ur)4.9 ( A)2 (M)15.7 (E)2 (S)2 ( i)2.6 (s)-12.9 ( t)4.2 (r)-5.9 (ue:)4.3 ( how)13.4 ( an )0.5 (ol)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (onc)-2 (ept)-6.6 ( )11.3 (s)-2 (t)-6.6 (i)2.6 (l)2.6 (l)2.6 ( hi)2.7 (t)-6.6 (s)-2 ( )11.2 (t)-6.6 (he)10.5 ( m)-6 (a)10.5 (r)5 (k)-2 (:)-6.6 ( o)10.6 (r)-6 (,)4.3 ( r)-6 (i)2.6 (s)8.9 (k)-2 ( )11.3 (g)-11.3 (r)-5.9 (oup)10.5 ( as)-2 (s)-2 (i)13.5 (g)-11.3 (nm)4.9 (ent)-6.6 ( poi)2.6 (nt)-6.6 (s)8.8 ( )11.3 (t)-6.6 (he a)10.5 (r)-5.9 (r)-6 (ow)13.4 ( t)-6.6 (o )]TJ 0 -1.141 Td [(r)-6 (at)-6.6 (i)2.6 (onal)2.6 ( t)-6.7 (he)10.5 (r)-5.9 (apy)8.8 ( )0.5 (s)-2 (el)2.6 (ec)-2 (t)-6.6 (i)2.6 (on)10.5 ( i)2.6 (n di)13.4 (f)-6.6 (f)-17.5 (e)10.6 (r)-6 (ent)-6.6 (i)2.6 (a)10.6 (t)-6.7 (ed )11.3 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )11.3 (c)-2 (anc)-2 (er)-5.9 (.)4.2 ( A)2 (m)4.9 ( J)8.9 ( S)1.9 (ur)4.9 (g )]TJ 0.002 Tw 0 -1.152 Td [(1997;)-6.6 (174:)-6.6 (462)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td (468.)Tj 0 Tc 0 Tw 1.935 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)2 (v)8.8 (ai)2.6 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -8.652 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9374215)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 463.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 461.28 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 439.68 Tm [(204.)-6.7 ( C)2.7 (ady)8.8 ( B)2 (,)4.2 ( S)2 (edg)-11.2 (w)13.5 (i)2.6 (c)-2 (k)-2 ( )11.2 (C)2.7 (E)1.9 (,)-6.6 ( M)15.8 (ei)2.5 (s)-2 (s)-2 (ner)-6 ( )22.1 (W)-36.2 (A)12.8 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( )11.3 (R)2.6 (i)2.6 (s)-2 (k)-12.9 ( )11.3 (f)-6.6 (ac)8.9 (t)-6.6 (or)5 ( anal)2.6 (y)8.9 (s)-2 (i)2.6 (s)-2 ( i)2.6 (n )]TJ 0 -1.152 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (an)10.5 (c)-2 (er)-6 (.)4.2 ( C)2.7 (anc)-2 (er)4.9 ( 1979;)-6.6 (43)10.5 (:)-6.6 (810)]TJ 0 Tc 0 Tw 21.88 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(820.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)]TJ 0 Tc 0 Tw 7.641 0 Td ( )Tj EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw -29.859 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (427722)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 240 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 412.32 216.481 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 390.72 Tm [(205.)-6.7 ( Loh)10.6 ( K)1.9 (C)2.6 (,)-6.6 ( )11.3 (G)4.3 (r)-6 (eens)-2 (pan)10.5 ( FS)1.9 (,)-6.6 ( )11.3 (G)-6.6 (ee)10.5 ( L,)4.3 ( et)4.3 ( al)2.7 (.)4.2 ( P)2 (at)-6.6 (hol)13.5 (og)-11.3 (i)2.7 (c)-2 (al)2.6 ( )11.3 (t)-6.6 (um)-5.9 (o)10.5 (r)]TJ 0 Tc 0 Tw 27.087 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td (node)Tj 0 Tc 0 Tw 2.207 0 Td (-)Tj -0.002 Tc 0.007 Tw -29.63 -1.152 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (i)2.6 (s)-2 ( )11.2 (\()-5.9 (p)10.5 (T)-10.6 (N)2.7 (M)15.7 (\))-5.9 ( s)-2 (t)-6.6 (a)10.5 (g)-11.2 (i)13.4 (ng )11.2 (f)-17.5 (o)10.6 (r)-6 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( and )11.3 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-5.9 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (as)8.9 (:)-6.6 ( )]TJ 0 -1.141 Td [(a r)-5.9 (e)10.5 (t)-6.6 (r)-5.9 (os)-2 (pec)8.9 (t)-6.6 (i)2.6 (v)]TJ 5.978 0 Td [(e anal)2.6 (y)8.9 (s)-2 (i)2.6 (s)-2 ( o)10.5 (f)-17.5 ( 700)10.6 ( pat)-6.6 (i)2.6 (ent)4.2 (s)-2 (.)4.3 ( J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (n)10.6 (doc)-2 (r)-6 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab )]TJ 0.002 Tw -5.978 -1.141 Td [(1997;)-6.6 (82:)-6.6 (3553)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(3562.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9360506)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 340.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 338.04 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 316.44 Tm [(206.)-6.7 ( Li)2.6 (n J)-2 (D)13.4 (,)-6.6 ( K)2 (ao)10.6 ( P)1.9 (F,)4.3 ( )22.1 (W)-36.2 (e)21.3 (ng H)2.7 (F,)-6.6 ( e)10.5 (t)-6.6 ( )11.2 (al)2.6 (.)-6.6 ( R)2.6 (el)2.6 (at)-6.6 (i)2.6 (v)8.9 (e v)8.9 (al)-8.3 (ue o)10.5 (f)-6.6 ( t)-6.6 (hal)2.6 (l)2.6 (i)2.6 (um)]TJ 0 Tc 0 Tw 27.761 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(201)10.5 ( )]TJ 1.935 0 Td (and )Tj -30.033 -1.141 Td [(i)2.6 (odi)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 2.989 0 Td [(131 s)-2 (c)-2 (ans)-2 ( i)2.6 (n)10.5 ( t)-6.6 (he)10.6 ( d)10.5 (et)-6.6 (ec)-2 (t)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( )11.3 (r)-6 (ec)-2 (u)10.5 (r)-6 (r)-5.9 (enc)-2 (e)10.5 ( or)5 ( )11.2 (di)2.6 (s)-2 (t)-6.6 (ant)-6.6 ( )11.3 (m)-6 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (as)-2 (i)2.6 (s)8.9 ( o)10.5 (f)-6.6 ( )]TJ -2.989 -1.152 Td [(w)13.5 (e)-11.2 (l)2.6 (l)2.6 ( di)2.6 (f)-6.6 (f)-17.4 (e)10.5 (r)-6 (ent)-6.6 (i)2.6 (a)10.5 (t)-6.5 (ed )11.3 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (no)10.5 (m)-6 (a.)4.2 ( E)2 (ur)5 ( J)-2 ( N)2.6 (uc)-2 (l)2.6 ( )11.3 (M)15.8 (ed 1998;)-6.6 (25:)-6.6 (695)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 29.424 0 Td [(700.)4.2 ( )]TJ 0.007 Tw -29.424 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)]TJ 21.989 0 Td (9662590)Tj EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 309.12 278.52 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 276.48 222.48 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 254.88 Tm [(207.)-6.7 ( B)2 (r)-6 (i)2.7 (e)10.5 (r)-6 (l)2.6 (ey)8.9 ( J)-2 (D)2.7 (,)-6.6 ( P)1.9 (anz)8.9 (ar)-6 (el)2.6 (l)2.7 (a T)-10.6 (,)4.3 ( )11.3 (T)-10.6 (s)-2 (an)10.5 (g R)24.4 (W)-36.3 (,)4.3 ( )11.3 (e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( )11.3 (A)1.9 ( c)-2 (om)-6 (pa)10.5 (r)-6 (i)2.6 (s)-2 (on )0.5 (o)10.5 (f)-6.6 ( di)13.5 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.5 (t)4.3 ( )]TJ 0 -1.152 Td [(s)-2 (t)-6.6 (a)10.5 (g)-11.2 (i)2.6 (ng s)-2 (y)8.9 (s)-2 (t)-6.6 (e)10.5 (m)-6 (s)-1.9 ( p)10.5 (r)-6 (edi)2.6 (c)-2 (t)-6.6 (a)10.5 (bi)2.6 (l)2.6 (i)2.6 (t)-6.6 (y)8.9 ( of)-17.4 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 ( )11.3 (out)-6.6 (c)-2 (o)10.5 (m)-5.9 (e.)4.3 ( )11.3 (T)-10.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)4.9 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( as)-2 ( an)10.6 ( )]TJ 0 -1.141 Td [(ex)8.8 (am)-6 (pl)2.6 (e.)-6.6 ( C)2.6 (anc)-1.9 (er)4.9 ( 1997;)-6.6 (7)10.5 (9:)-6.6 (2414)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.25 0 Td [(2423)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.25 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9191532)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 216.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 214.92 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 193.32 Tm [(208.)-6.7 ( C)2.7 (as)8.9 (t)-6.6 (a)10.5 (g)-11.2 (na M)15.8 (G)-6.6 (,)4.2 ( M)15.8 (ai)2.7 (n)-11.3 (o F,)4.3 ( C)2.6 (i)2.6 (pr)-5.9 (i)2.6 ( C)2.6 (,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( D)2.6 (el)2.6 (ay)8.8 (ed r)-5.9 (i)2.6 (s)8.8 (k)-2 ( s)-2 (t)4.3 (r)-5.9 (at)-6.6 (i)13.5 (f)-17.5 (i)2.6 (c)-2 (a)10.5 (t)-6.6 (i)2.6 (on,)-6.6 ( )11.3 (t)-6.6 (o)10.5 ( )]TJ 0 -1.152 Td [(i)2.6 (nc)-2 (l)2.6 (ude t)-6.6 (he )11.3 (r)-6 (es)-2 (pons)-2 (e)10.5 ( t)-6.6 (o)10.5 ( i)2.6 (ni)2.6 (t)-6.6 (i)2.7 (al)2.6 ( t)-6.6 (r)-5.9 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( )11.3 (\()-6 (s)-2 (ur)4.9 (g)-11.2 (e)10.5 (r)-5.9 (y)8.8 ( )11.3 (and r)-6 (adi)2.6 (oi)2.6 (odi)2.6 (ne abl)2.6 (at)-6.6 (i)2.6 (on\))4.9 (,)-6.6 ( )]TJ 0 -1.141 Td [(has)-2 ( bet)4.3 (t)-6.6 (er)4.9 ( out)4.3 (c)-2 (om)-6 (e)10.5 ( pr)-6 (edi)13.5 (c)-2 (t)-6.6 (i)2.6 (v)8.9 (i)2.6 (t)-6.6 (y)8.9 ( i)2.6 (n di)2.6 (f)-6.6 (f)-17.5 (e)10.5 (r)-6 (ent)-6.7 (i)2.7 (at)-6.6 (e)]TJ [(d)10.6 ( )11.2 (t)-6.6 (h)10.6 (y)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)-5.9 ( pa)10.6 (t)-6.7 (i)2.7 (ent)-6.6 (s)8.8 (.)-6.6 ( )]TJ 0 -1.152 Td [(E)2 (ur)-5.9 ( J)8.8 ( E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( 2011)10.5 (;)-6.6 (1)10.5 (65:)-6.6 (441)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.022 0 Td [(446)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.022 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21750043)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 142.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 140.64 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 119.04 Tm [(209.)-6.7 ( )11.3 (T)-10.5 (u)10.5 (t)-6.6 (t)-6.6 (l)2.6 (e R)2.6 (M)15.8 (,)-6.6 ( )11.3 (T)-10.6 (al)2.6 (a H)2.6 (,)4.3 ( )11.3 (S)1.9 (hah J)-2 (,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( E)2 (s)8.8 (t)-6.6 (i)2.6 (m)-5.9 (a)10.5 (t)-6.6 (i)2.6 (ng )11.3 (r)-6 (i)2.6 (s)-2 (k)-2 ( o)10.5 (f)-6.6 ( )11.3 (r)-5.9 (ec)-2 (ur)4.9 (r)-6 (enc)-2 (e i)2.6 (n)10.5 ( )]TJ -0.005 Tc 0.005 Tw 0 -1.152 Td [(d)-3.3 (if)]TJ -0.002 Tc 0.007 Tw 1.054 0 Td [(f)-6.6 (er)-6 (en)10.6 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (an)10.5 (c)-2 (er)-6 ( a)10.5 (f)-6.5 (t)-6.7 (e)10.6 (r)-6 ( )11.3 (t)-6.6 (ot)-6.6 (al)13.5 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (dec)-2 (t)-6.6 (o)10.5 (m)-6 (y)8.9 ( and r)-6 (adi)2.6 (oac)8.9 (t)-6.6 (i)2.6 (v)8.9 (e )]TJ -1.054 -1.141 Td [(i)2.6 (odi)2.6 (ne r)-5.9 (em)-5.9 (nan)10.5 (t)-6.6 ( abl)2.6 (at)-6.7 (i)2.7 (on:)4.2 ( )11.3 (us)-2.1 (i)2.7 (ng)-11.2 ( )11.3 (r)-6 (es)-2 (pons)-2 (e)10.6 ( t)-6.6 (o)10.6 ( t)-6.7 (he)10.5 (r)-5.9 (ap)10.5 (y)8.9 ( v)8.9 (ar)-5.9 (i)2.6 (abl)2.6 (es)-1.9 ( t)-6.7 (o m)-6 (odi)13.4 (f)-17.5 (y)8.9 ( t)-6.6 (h)10.5 (e )]TJ 0 -1.141 Td [(i)2.6 (ni)2.6 (t)-6.6 (i)2.6 (al)2.6 ( r)-5.9 (i)2.6 (s)-2 (k)-2 ( es)-2 (t)-6.6 (i)13.5 (m)-5.9 (at)-6.6 (es)8.8 ( pr)-6 (ed)10.5 (i)2.6 (c)-2 (t)-6.6 (ed by)8.9 ( t)-6.6 (he)10.5 ( new)13.5 ( A)1.9 (m)-5.9 (er)-5.9 (i)2.6 (c)8.8 (an )11.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d A)2 (s)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (i)2.6 (on )]TJ 0 -1.152 Td [(s)-2 (t)-6.6 (a)10.5 (g)-11.2 (i)2.6 (ng s)-2 (y)8.9 (s)-2 (t)-6.6 (e)10.5 (m)-6 (.)4.3 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d 2010;)-6.6 (20:)-6.6 (1341)]TJ 0 Tc 0 Tw 16.902 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td (13)Tj 0.007 Tw [(49.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -17.239 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21034228)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 55.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 53.76 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(210.)-6.7 ( V)2 (ai)2.6 (s)-2 (m)-6 (an)10.5 ( F,)4.2 ( M)15.8 (om)-6 (es)-2 (s)-2 (o D)2.6 (,)4.3 ( B)2 (ul)2.6 (z)8.9 (i)2.6 (c)-2 (o D)2.6 (A)1.9 (,)-6.6 ( et)-6.6 ( al)13.5 (.)-6.6 ( )11.2 (S)2 (pont)-6.7 (aneous)-2 ( )11.3 (r)-6 (em)-6 (i)2.6 (s)-2 (s)-2 (i)2.6 (on i)13.4 (n )]TJ 0 -1.152 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 ( pat)-6.5 (i)2.6 (en)10.5 (t)-6.6 (s)-2 ( a)10.5 (f)-6.6 (t)-6.6 (e)10.6 (r)-6 ( bi)2.7 (oc)-2 (he)10.5 (m)-6 (i)2.6 (c)-2 (al)2.6 ( i)2.6 (nc)-2 (om)-5.9 (pl)13.5 (et)-6.6 (e )11.3 (r)-6 (es)-2 (pons)-2 (e )]TJ -0.005 Tc 0.01 Tw 27.587 0 Td [(t)-9.6 (o)7.5 ( in)-3.4 (it)-9.6 (ia)-3.3 (l )]TJ -0.002 Tc 0.007 Tw -27.587 -1.141 Td [(t)-6.6 (her)-6 (apy)8.9 (.)-6.6 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.7 (nol)2.6 ( )11.2 (\()-5.9 (O)-6.6 (x)19.7 (f)-17.5 (\))4.9 ( )0.5 (2012;)-6.7 (77)10.5 (:)-6.6 (132)]TJ 0 Tc 0 Tw 18.891 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(138.)4.2 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -19.228 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22248037)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 473.88 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 452.28 Tm [(211.)-6.7 ( P)2 (i)2.6 (t)-6.6 (oi)2.6 (a F)11.2 (,)-6.6 ( B)1.9 (ueno)10.5 ( F,)4.3 ( )11.3 (U)2.6 (r)-6 (c)-2 (i)2.6 (uol)2.6 (i)2.6 ( C)2.6 (,)-6.6 ( et)4.3 ( al)2.6 (.)4.3 ( O)-6.6 (u)10.5 (t)-6.6 (c)-2 (o)10.5 (m)4.9 (es)-2 ( o)10.5 (f)-6.6 ( pat)-6.6 (i)2.6 (en)10.6 (t)-6.6 (s)-2 ( w)13.4 (i)2.6 (t)-6.6 (h )]TJ 0.002 Tw 0 -1.141 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)]TJ -0.004 Tw 3.609 0 Td [(i)2.6 (at)-6.6 (ed t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d )-10.6 (c)-2 (an)10.5 (c)-2 (er)-5.9 ( r)-5.9 (i)2.6 (s)8.9 (k)]TJ 0 Tc 0 Tw 10.522 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(s)8.9 (t)-6.6 (r)-6 (a)10.5 (t)-6.6 (i)13.5 (f)-17.5 (i)2.6 (ed ac)-2 (c)8.9 (or)-5.9 (di)13.5 (ng t)-6.6 (o)10.5 ( t)-6.6 (he)10.6 ( A)1.9 (m)-5.9 (e)10.5 (r)-6 (i)2.6 (c)-2 (an )]TJ -14.467 -1.152 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d as)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (i)2.7 (on and)10.5 ( L)10.5 (at)-6.5 (i)2.5 (n A)2 (m)-6 (e)10.5 (r)-5.9 (i)2.6 (c)-2 (an )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d s)-2 (o)10.6 (c)-2 (i)2.6 (et)-6.6 (y)8.9 ( r)-6 (i)2.6 (s)-2 (k)-2 ( o)10.6 (f)-6.7 ( )11.3 (r)-5.9 (ec)-2 (ur)4.9 (r)-6 (enc)-2 (e )]TJ 0 -1.141 Td [(c)-2 (l)2.6 (as)-2 (s)-2 (i)2.6 (f)-17.5 (i)2.6 (c)-2 (a)10.5 (t)-6.6 (i)2.6 (on s)-2 (y)8.9 (s)-2 (t)-6.6 (e)10.5 (m)-5.9 (s)-2 (.)4.2 ( )11.3 (Thy)8.8 (r)-5.9 (oi)2.6 (d 2013;)-6.6 (23:)-6.6 (1401)]TJ 0 Tc 0 Tw 19.826 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(140)10.5 (7.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -20.163 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (23517313)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 401.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 399.72 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.005 Tc 0.01 Tw 11.04 -0 0 11.04 405 378 Tm [(2)-3.3 (1)-3.4 (2)-3.3 (.)-9.7 ( )11.3 (T)-13.6 (u)7.5 (t)-9.6 (t)-9.6 (le)-3.4 ( RM)12.8 (.)-9.6 ( Ris)5.9 (k)]TJ 0 Tc 0 Tw 9.033 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(ada)10.5 (pt)-6.6 (ed )11.2 (m)-5.9 (ana)10.5 (g)-11.2 (em)-6 (en)10.5 (t)4.2 ( o)10.6 (f)-6.6 ( t)-6.6 (hy)8.9 (r)4.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 (.)-6.6 ( E)1.9 (ndoc)8.8 (r)-5.9 ( )]TJ -9.37 -1.141 Td [(P)2 (r)-6 (ac)-2.1 (t)4.3 ( 2008;)-6.6 (14)10.5 (:)-6.6 (764)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 8.489 0 Td [(774)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -8.489 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (1899680)]TJ 0 Tc 0 Tw (0)Tj EMC ET /Span <>BDC BT /CS1 cs 0 scn 11.04 -0 0 11.04 633.72 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 350.76 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 329.16 Tm [(213.)-6.7 ( B)2 (i)2.6 (l)2.6 (i)2.6 (m)-5.9 (or)-5.9 (i)2.6 (a K)2 (Y)1.9 (,)4.3 ( Zanoc)8.9 (c)-2.1 (o K)2 (,)4.2 ( S)2 (t)-6.6 (ur)4.9 (geon )0.5 (C)2.5 (.)4.3 ( I)4.3 (m)-6 (pac)8.9 (t)-6.6 ( o)10.5 (f)-6.6 ( s)-2 (u)10.5 (r)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( t)4.3 (r)-6 (eat)4.3 (m)-6 (en)10.6 (t)-6.6 ( on)10.5 ( )]TJ 0 -1.152 Td [(out)-6.6 (c)-2 (om)-6 (e)10.5 (s)-2 ( )11.3 (f)-6.6 (or)5 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)-5.9 (.)4.2 ( A)2 (dv)8.9 ( S)2 (ur)4.9 (g)-11.2 ( 2)10.5 (008;)-6.6 (42:)-6.6 (1)]TJ 0 Tc 0 Tw 25.652 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(12.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e )]TJ -0.006 Tc 0.006 Tw -25.989 -1.141 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (18953806)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 648.96 303.84 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 420.36 301.8 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 280.2 Tm [(214.)-6.7 ( H)2.7 (ay)8.9 ( I)-6.6 (D)2.6 (,)4.2 ( )11.3 (G)-6.6 (r)-6 (an)10.5 (t)-6.6 ( C)2.6 (S)2 (,)4.2 ( )11.3 (T)-10.5 (ay)8.9 (l)2.6 (or)-5.9 ( )22.1 (W)-36.3 (F)11.2 (,)4.3 ( M)15.8 (c)-2 (C)2.6 (onahey)8.9 ( W)-36.2 (M)26.6 (.)4.3 ( )11.2 (I)-6.6 (ps)-2 (i)2.6 (l)2.6 (at)-6.6 (er)-6 (al)2.6 ( l)2.6 (obec)8.8 (t)-6.6 (om)4.9 (y)8.9 ( )]TJ 0 -1.152 Td [(v)8.9 (er)-5.9 (s)-2 (us)-2 ( bi)2.6 (l)2.6 (at)-6.6 (er)-6 (al)2.6 ( l)2.6 (obar)4.9 ( r)-6 (es)8.8 (ec)-2 (t)-6.6 (i)2.6 (on i)2.6 (n papi)2.6 (l)2.6 (l)2.7 (ar)-5.9 (y)8.8 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.6 (m)-6 (a:)4.2 ( a )]TJ 0 -1.141 Td [(r)-6 (et)-6.6 (r)4.9 (os)-2 (pec)-2 (t)-6.6 (i)2.6 (v)8.8 (e anal)2.7 (y)8.8 (s)-2 (i)2.6 (s)-2 ( o)10.6 (f)-17.5 ( )11.3 (s)-2.1 (ur)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( out)-6.6 (c)-2 (o)10.5 (m)-6 (e)10.6 ( us)-2 (i)2.6 (ng a)10.6 ( nov)8.9 (el)2.6 ( pr)-5.9 (og)-11.2 (no)10.5 (s)-2 (t)-6.6 (i)2.6 (c)-2 ( )]TJ 0 -1.152 Td [(s)-2 (c)-2 (or)-6 (i)2.6 (ng s)-2 (y)8.9 (s)-2 (t)-6.6 (e)10.5 (m)-6 (.)4.3 ( S)2 (ur)4.9 (g)-11.2 (e)10.5 (r)-5.9 (y)8.8 ( )0.5 (1987;)-6.7 (102:)-6.6 (1088)]TJ 0 Tc 0 Tw 17.62 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1095.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)]TJ 4.913 0 Td [(abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.87 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (3686348)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 229.56 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 227.52 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 205.92 Tm [(215.)-6.7 ( H)2.7 (ay)8.9 ( I)-6.6 (D)2.6 (,)4.2 ( )11.3 (G)-6.6 (r)-6 (an)10.5 (t)-6.6 ( C)2.6 (S)2 (,)4.2 ( )11.3 (B)2 (er)-5.9 (gs)-2 (t)4.3 (r)-6 (al)2.6 (h E)2 (J)-2 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( U)2.6 (ni)2.7 (l)2.6 (at)-6.6 (er)-6 (al)2.6 ( )11.2 (t)-6.6 (ot)-6.6 (al)2.6 ( l)2.6 (obec)8.9 (t)-6.6 (om)-5.9 (y)8.8 (:)4.3 ( i)2.6 (s)-2 ( )11.3 (i)2.6 (t)-6.6 ( )]TJ 0 -1.141 Td [(s)-2 (u)10.5 (f)-6.6 (f)-17.5 (i)2.7 (c)-2.1 (i)2.7 (ent)4.2 ( s)-2 (ur)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( )11.3 (t)-6.6 (r)-6 (ea)10.5 (t)4.3 (m)4.9 (ent)-6.6 ( )11.3 (f)-6.6 (or)4.9 ( pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h A)2 (M)15.8 (E)-8.9 (S)1.9 ( l)2.6 (ow)]TJ 0 Tc 0 Tw 24.239 0 Td (-)Tj -0.005 Tc 0.01 Tw 0.337 0 Td [(r)-9 (is)-5 (k)-15.8 ( p)-3.3 (a)-3.4 (p)-3.3 (illa)-3.4 (r)-8.9 (y)5.9 ( )]TJ -0.002 Tc 0.007 Tw -24.576 -1.152 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a? S)2 (ur)4.9 (ger)-5.9 (y)8.9 ( 1998;)-6.6 (124:)-6.6 (958)]TJ 0 Tc 0 Tw 18.565 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(964;)4.2 ( di)13.4 (s)-2 (c)-2 (us)-2 (s)-2 (i)2.6 (on 964)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 9.141 0 Td [(956)10.5 (.)-6.6 ( )]TJ 0.007 Tw -28.043 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (9854569)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 690.6 168 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 165.96 222.48 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 405 144.36 Tm [(216.)-6.7 ( )-10.6 (D)2.7 (ac)8.9 (k)-12.9 (i)2.6 (w)13.5 ( )-10.6 (A)1.9 (P)2 (,)-6.6 ( )-10.6 (Zei)13.4 (g)-11.2 (er)4.9 ( M)15.8 (.)-6.6 ( )-10.6 (E)2 (x)8.9 (t)-6.7 (ent)-6.7 ( )-10.6 (o)10.6 (f)-17.5 ( s)-1.9 (ur)4.9 (g)-11.2 (e)10.5 (r)-5.9 (y)8.8 ( f)-17.5 (or)4.9 ( di)2.6 (f)-6.6 (f)-6.6 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ 0.007 Tw 0 -1.152 Td [(c)-2 (anc)-2 (er)-6 (.)4.3 ( S)1.9 (ur)4.9 (g C)2.7 (l)2.5 (i)2.7 (n N)2.6 (or)-6 (t)-6.6 (h)10.6 ( )11.2 (A)2 (m)-6 ( 2004)10.5 (;)-6.6 (84:)-6.6 (817)]TJ 0 Tc 0 Tw 17.946 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(832.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -18.283 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (15145237)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 119.04 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 117 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 95.4 Tm [(217.)-6.7 ( M)15.8 (az)-2 (z)8.8 (af)-17.5 (er)4.9 (r)-6 (i)2.7 ( E)1.9 (L.)4.2 ( )11.3 (T)-10.6 (r)-5.9 (ea)10.6 (t)-6.7 (i)2.6 (ng di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (a)10.5 (t)-6.6 (ed )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (a:)4.3 ( w)13.5 (her)-6 (e do )]TJ 0 -1.152 Td [(w)13.5 (e dr)-6 (aw)13.5 ( t)-6.6 (he l)2.7 (i)2.6 (ne? M)15.8 (a)-11.2 (y)8.9 (o )-10.5 (C)2.7 (l)2.6 (i)2.6 (n P)2 (r)-6 (oc)-2 ( 1991;)-6.6 (66)10.6 (:)-6.7 (105)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 20.957 0 Td [(1)10.5 (11.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -20.957 -1.141 Td [(h)6.7 (ttp)17.6 (:/)]TJ -0.002 Tc 0.002 Tw 2.217 0 Td [(/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.7 (m)-6 (.)-6.6 (ni)2.7 (h.)4.3 (gov)8.9 (/)-6.7 (pubm)-6 (ed/)-6.6 (1988750)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 70.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 68.04 222.6 0.84 re f EMC endstream endobj 996 0 obj 28144 endobj %% Contents for page 115 %% Original object ID: 231 0 997 0 obj << /Length 998 0 R >> stream Q q BT /Xi113 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 998 0 obj 246 endobj %% Original object ID: 11687 0 999 0 obj [ 2868 0 R 2869 0 R 2870 0 R 2871 0 R 2872 0 R 2873 0 R 2874 0 R 2875 0 R 2876 0 R 2877 0 R 2878 0 R 2879 0 R 2880 0 R 2881 0 R 2882 0 R 2883 0 R ] endobj %% Contents for page 116 %% Original object ID: 232 0 1000 0 obj << /Length 1001 0 R >> stream q endstream endobj 1001 0 obj 2 endobj %% Contents for page 116 %% Original object ID: 11688 0 1002 0 obj << /Length 1003 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (53)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(218.)-6.7 ( M)15.8 (as)-2 (s)-2 (i)2.6 (n J)-1.9 (P)1.9 (,)-6.6 ( S)1.9 (av)8.9 (oi)2.6 (e )11.3 (J)-2 (C)2.6 (,)-6.6 ( )11.2 (G)-6.6 (ar)-6 (ni)2.6 (er)4.9 ( H)2.7 (,)4.2 ( et)4.2 ( al)2.6 (.)4.2 ( P)2 (ul)2.6 (m)-6 (onar)-6 (y)8.9 ( m)-6 (e)10.5 (t)-6.6 (as)8.9 (t)-6.7 (as)-2 (es)8.8 ( i)2.6 (n )]TJ 0 -1.152 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (a)10.5 (r)5 (c)-2 (i)2.6 (nom)-6 (a.)4.2 ( S)2 (t)-6.6 (udy)8.8 ( )0.5 (o)10.5 (f)-6.6 ( 58 c)-2 (a)10.5 (s)8.9 (es)-2 ( w)13.5 (i)2.6 (t)-6.6 (h i)2.7 (m)-6 (pl)2.7 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (ons)-2 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )]TJ 0 -1.141 Td [(t)-6.6 (he p)10.5 (r)-5.9 (i)2.6 (m)-6 (ar)-6 (y)8.9 ( )11.3 (t)-6.7 (um)-6 (o)10.6 (r)-6 ( )11.3 (t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)4.9 (ent)-6.6 (.)4.2 ( C)2.7 (anc)-2 (er)4.9 ( 1984;)-6.6 (53)10.5 (:)-6.6 (982)]TJ 0 Tc 0 Tw 21.88 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(992.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.217 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (6692296)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 473.88 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 452.28 Tm [(219.)-6.7 ( S)2 (haha)10.5 ( A)1.9 (R)2.7 (.)-6.7 ( )11.3 (I)-6.6 (m)-6 (pl)2.6 (i)2.6 (c)-2 (at)-6.6 (i)13.5 (ons)-2 ( o)10.6 (f)-6.6 ( pr)-5.9 (o)10.5 (g)-11.2 (no)10.5 (s)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (f)-6.6 (ac)8.8 (t)-6.6 (or)-6 (s)8.9 ( and )11.3 (r)-5.9 (i)2.6 (s)8.8 (k)-12.8 ( )11.2 (gr)-6 (oups)-2 ( i)2.6 (n )11.2 (t)-6.6 (he)10.5 ( )]TJ 0 -1.141 Td [(m)-6 (ana)10.6 (g)-11.2 (em)-5.9 (en)10.5 (t)-6.6 ( o)10.6 (f)-6.7 ( )11.3 (di)13.5 (f)-6.6 (f)-17.5 (e)10.6 (r)-6 (ent)-6.6 (i)13.5 (at)-6.6 (ed )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 (.)-6.6 ( La)10.5 (r)-5.9 (y)8.8 (ng)-11.2 (os)-2 (c)-2 (ope)10.6 ( )]TJ 0.002 Tw 0 -1.152 Td [(2004;)-6.6 (114:)-6.6 (393)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(402.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)-8.3 (abl)2.6 (e at)]TJ -0.006 Tc 0.006 Tw 7.37 0 Td (: )Tj EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw -13.804 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (15091208)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 412.32 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 390.72 Tm [(220.)-6.7 ( B)2 (r)-6 (i)13.5 (t)-6.6 (o J)-2 (P)12.8 (,)-6.6 ( H)2.6 (ay)8.9 ( I)-6.6 (D)13.5 (,)-6.6 ( M)15.8 (or)-5.9 (r)-6 (i)2.6 (s)-2 ( J)-2 (C)13.5 (.)-6.6 ( Low)13.5 ( r)-6 (i)2.6 (s)8.9 (k)-2 ( papi)2.7 (l)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (d c)-2 (anc)-2 (er)4.9 (.)-6.6 ( B)1.9 (M)15.8 (J)-2 ( )]TJ 0 -1.152 Td [(2014;)-6.6 (348:)4.2 (g)-11.2 (3045)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 0 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24935445)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 365.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 363.36 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 341.76 Tm [(221.)-6.7 ( M)15.8 (az)-2 (z)8.8 (af)-17.5 (er)4.9 (r)-6 (i)2.7 ( E)1.9 (L.)4.2 ( M)15.8 (an)-11.3 (ag)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d m)-5.9 (i)2.6 (c)8.9 (r)-6 (oc)-2 (ar)-5.9 (c)-2 (i)2.6 (n)10.5 (om)-5.9 (as)-2 (.)4.3 ( Y)2 (ons)-2 (ei)2.6 ( M)15.8 (ed J)-2 ( )]TJ 0.002 Tw 0 -1.141 Td [(2012;)-6.6 (53:)-6.6 (1)]TJ 0 Tc 0 Tw 4.435 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(14.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e )-10.4 (at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -4.772 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (2218722)]TJ 0 Tc 0 Tw (8)Tj EMC ET /Span <>BDC BT /CS1 cs 0 scn 11.04 -0 0 11.04 252.24 316.44 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 314.4 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 292.8 Tm [(222.)-6.7 ( N)2.7 (o)10.5 (g)-11.2 (uc)-2 (hi)2.6 ( S)12.8 (,)-6.6 ( Y)1.9 (a)10.6 (m)-6 (as)-2 (h)10.5 (i)2.6 (t)-6.6 (a H)2.6 (,)4.3 ( U)2.6 (c)-2 (hi)2.6 (no S)2 (,)4.2 ( )22.1 (W)-36.2 (a)10.5 (t)4.3 (ana)10.5 (be S)2 (.)-6.6 ( P)2 (api)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( )]TJ 0 -1.141 Td [(m)-6 (i)2.7 (c)-2 (r)-6 (oc)-2 (a)10.5 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( )33 (W)-36.3 (o)10.6 (r)-6 (l)2.6 (d J)8.8 ( S)2 (ur)4.9 (g)-11.3 ( )0.5 (2008)10.5 (;)-6.6 (32)10.5 (:)-6.6 (747)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 19.511 0 Td [(753)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -19.511 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (18264828)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 267.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 265.44 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 243.84 Tm [(223.)-6.7 ( M)15.8 (at)-6.6 (s)-2 (uz)8.9 (u K)1.9 (,)-6.6 ( S)2 (u)10.5 (g)-11.2 (i)2.6 (no )11.2 (K)2 (,)-6.6 ( M)]TJ 12.902 0 Td [(as)-2 (udo K)2 (,)-6.7 ( )0.5 (e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( )11.2 (T)-10.5 (hy)8.9 (r)4.9 (oi)2.6 (d )0.5 (l)2.6 (obec)-2 (t)-6.6 (om)-6 (y)8.9 ( )11.2 (f)-17.4 (o)10.5 (r)-6 ( )]TJ -12.902 -1.141 Td [(papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)-6 (:)-6.6 ( l)13.5 (ong)]TJ 0 Tc 0 Tw (-)Tj -0.005 Tc -0.001 Tw 13.022 0 Td [(t)-9.6 (e)7.5 (r)-9 (m)1.9 ( f)-20.5 (o)-3.3 (llo)-3.4 (w)]TJ 0 Tc 0 Tw 4.804 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up s)-2 (t)-6.6 (udy)8.9 ( o)10.5 (f)-6.6 ( 1,)-6.6 (088)10.5 ( c)-1.9 (as)-2 (es)8.8 (.)-6.6 ( )33 (W)-36.2 (o)10.5 (r)-6 (l)2.6 (d )11.3 (J)-2 ( )]TJ -18.163 -1.152 Td [(S)2 (ur)-5.9 (g 2014;)-6.6 (3)10.5 (8:)-6.6 (68)]TJ 0 Tc 0 Tw 7.37 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(79.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -7.707 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24081532)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 205.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 203.88 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 23.52 182.28 Tm (224)Tj 0.007 Tw [(.)-6.7 ( H)2.7 (ay)8.9 ( I)-6.6 (D)2.6 (,)4.2 ( H)2.7 (ut)4.3 (c)-2 (hi)2.6 (ns)-2 (on )11.2 (M)5 (E)1.9 (,)-6.6 ( G)-6.6 (onz)8.9 (al)2.7 (ez)]TJ 0 Tc 0 Tw 17.326 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(Los)-2 (ada )11.2 (T)-10.5 (,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( P)1.9 (api)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ -17.663 -1.141 Td [(m)-6 (i)2.7 (c)-2 (r)-6 (oc)-2 (a)10.5 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (:)-6.6 ( a)10.5 ( s)-2 (t)-6.6 (udy)8.9 ( )11.2 (o)10.6 (f)-17.5 ( 900)10.5 ( c)-2 (as)-2 (es)8.9 ( obs)-2 (er)-6 (v)8.9 (ed i)2.6 (n)10.5 ( a 60)]TJ 0 Tc 0 Tw 24.37 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(y)8.9 (ear)-6 ( per)-5.9 (i)2.6 (od.)4.2 ( )]TJ -24.707 -1.152 Td [(S)2 (ur)-5.9 (g)-11.3 (e)10.6 (r)-6 (y)8.9 ( 2008;)-6.6 (144)10.5 (:)-6.6 (980)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 10.207 0 Td [(9)10.5 (87;)-6.6 ( di)2.6 (s)-2 (c)-2 (us)-2 (s)-2 (i)2.7 (on)10.5 ( 987)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 9.141 0 Td [(988)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -19.348 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19041007)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 144.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 142.32 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 120.72 Tm [(225.)-6.7 ( M)15.8 (et)-6.6 (e )11.3 (O)-6.6 (,)4.2 ( R)2.7 (ot)-6.6 (s)8.9 (t)-6.6 (ei)2.6 (n L,)4.3 ( )11.3 (A)1.9 (s)-2 (a S)1.9 (L.)-6.6 ( C)2.6 (on)10.6 (t)-6.7 (r)-5.9 (ov)8.9 (er)-6 (s)-2 (i)2.6 (es)-2 ( i)2.6 (n)10.5 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d pat)-6.6 (hol)2.6 (o)10.5 (g)-11.2 (y)8.9 (:)-6.6 ( )]TJ 0 -1.152 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (aps)-2 (ul)2.7 (e i)2.6 (nv)8.8 (as)-2 (i)2.6 (on and ex)8.9 (t)-6.6 (r)-6 (at)-6.7 (hy)8.9 (r)-6 (oi)2.6 (dal)2.6 ( ex)8.8 (t)-6.6 (en)10.5 (s)-2 (i)2.6 (on.)-6.6 ( A)2 (nn S)1.9 (u)10.5 (r)4.9 (g)-11.2 ( )11.3 (O)-6.6 (nc)-2 (ol)2.6 ( )]TJ 0.002 Tw 0 -1.141 Td [(2010;)-6.6 (17:)-6.6 (386)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(391.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.7 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19949881)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 82.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 80.64 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 59.04 Tm [(226.)-6.7 ( )11.3 (O)-6.6 (r)4.9 (t)-6.6 (i)2.6 (z)8.9 ( S)1.9 (,)-6.6 ( R)2.7 (odr)-6 (i)13.5 (g)-11.2 (uez)8.8 ( )11.3 (J)-2 (M)15.8 (,)-6.6 ( S)1.9 (or)-6 (i)2.6 (a T,)-6.6 ( e)10.5 (t)4.3 ( al)2.6 (.)-6.6 ( E)2 (x)8.8 (t)-6.5 (r)-6 (a)10.5 (t)4.3 (hy)8.9 (r)-6 (oi)2.6 (d s)-2.1 (pr)-6 (ead i)2.6 (n papi)2.6 (l)2.6 (l)2.7 (ar)-5.9 (y)8.8 ( )]TJ 0 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.6 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d:)4.3 ( c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (opat)-6.6 (hol)2.6 (og)-11.2 (i)2.6 (c)-2 (al)2.7 ( and)10.5 ( )11.3 (pr)-6 (o)10.6 (g)-11.3 (nos)-2 (t)-6.7 (i)2.7 (c)8.8 ( s)-2 (t)-6.6 (udy)8.9 (.)4.3 ( )]TJ 0.002 Tw 34.554 42.348 Td [(O)-6.6 (t)-6.6 (ol)2.6 (ar)-6 (y)8.9 (n)]TJ 0.007 Tw 3.761 0 Td [(g)-11.2 (ol)2.6 ( H)2.7 (ead N)2.6 (ec)8.8 (k)-2 ( )11.3 (S)2 (ur)-5.9 (g 2001;)-6.6 (1)10.5 (24:)-6.6 (261)]TJ 0 Tc 0 Tw 15.293 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(265.)4.2 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -19.391 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (11240987)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 499.2 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 477.6 Tm [(227.)-6.7 ( )11.3 (G)-6.6 (r)-5.9 (i)13.4 (g)-11.2 (s)-2 (by)8.8 ( P)23.7 (W)-25.4 (,)4.3 ( R)2.6 (eddy)8.9 ( R)2.6 (M)15.8 (,)-6.6 ( M)15.8 (o)-11.2 (l)2.6 (e)-11.2 (y)8.8 ( )0.5 (J)-2 (F,)-6.7 ( H)2.7 (al)2.6 (l)2.6 ( B)2 (L.)4.3 ( )11.3 (C)2.6 (ont)-6.6 (r)-6 (al)2.6 (at)-6.6 (e)10.6 (r)-6 (al)2.7 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 ( at)4.3 ( c)-1.9 (o)10.5 (m)-6 (pl)2.6 (et)-6.6 (i)2.6 (on t)]TJ 13.033 0 Td [(hy)8.8 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (o)10.5 (m)-5.9 (y)8.9 ( has)-2 ( n)10.5 (o i)2.7 (m)-6 (pac)8.9 (t)-6.6 ( on)10.5 ( r)-5.9 (ec)-2 (u)10.6 (r)-6 (r)-5.9 (enc)-2 (e)10.5 ( )]TJ -13.033 -1.152 Td [(or)-6 ( s)-2 (u)10.5 (r)-5.9 (v)8.8 (i)2.6 (v)8.9 (a)-11.2 (l)2.6 ( af)-6.5 (t)-6.7 (er)4.9 ( r)-6 (adi)2.7 (oi)2.6 (odi)2.6 (ne t)4.3 (r)-6 (eat)4.2 (m)-5.9 (ent)4.2 (.)-6.6 ( S)2 (u)10.5 (r)4.9 (g)-11.2 (er)-6 (y)8.9 ( 20)10.5 (06;)-6.6 (140:)-6.6 (1043)]TJ 0 Tc 0 Tw 27.424 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(1047;)4.3 ( )]TJ 0.007 Tw -27.761 -1.141 Td [(di)2.6 (s)-2 (c)-2 (us)-2 (s)-2 (i)2.6 (on 1047)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 7.489 0 Td [(1049)10.5 (.)-6.6 ( A)12.8 (v)8.9 (ai)-8.3 (l)2.7 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -7.489 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (17188155)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 426.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 424.92 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 405 403.32 Tm [(228.)-6.7 ( )]TJ 0.007 Tw 2.228 0 Td [(K)2 (i)2.6 (m)4.9 ( E)1.9 (S)2 (,)4.2 ( )0.5 (K)1.9 (i)2.6 (m)-5.9 ( )11.2 (T)-10.5 (Y)12.8 (,)-6.6 ( K)12.8 (oh J)-2 (M)15.8 (,)-6.6 ( et)-6.6 ( )11.3 (al)2.6 (.)-6.7 ( C)2.7 (o)10.5 (m)-6 (pl)2.6 (et)-6.6 (i)2.6 (on )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.7 (om)-6 (y)8.9 ( i)2.6 (n pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( )]TJ -2.228 -1.141 Td [(w)2.6 (i)2.6 (t)-6.6 (h t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-1.9 (e)10.5 (r)-6 ( w)13.5 (ho i)2.6 (ni)2.6 (t)-6.6 (i)2.6 (al)2.6 (l)-8.2 (y)8.8 ( under)-5.9 (w)13.5 (ent)-6.6 ( uni)2.6 (l)2.6 (at)-6.6 (er)-6 (al)2.6 ( oper)-6 (a)10.5 (t)-6.6 (i)2.6 (on.)-6.6 ( C)2.6 (l)2.6 (i)2.6 (n )]TJ 0 -1.152 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( \()4.9 (O)-6.6 (x)8.9 (f)-6.7 (\))-5.9 ( 2004)10.5 (;)-6.6 (61)10.6 (:)-6.7 (145)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.359 0 Td [(148)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -13.359 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)]TJ -0.002 Tc 0.002 Tw 3.935 0 Td [(w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.8 (/)-6.6 (pubm)-6 (ed/)-6.6 (15212657)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 365.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 363.36 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 341.76 Tm [(229.)-6.7 ( D)2.7 (e)10.5 (G)-6.6 (r)-6 (oo)10.5 (t)-6.6 ( LJ)8.9 (,)-6.6 ( K)1.9 (apl)2.6 (an)10.6 ( E)2 (L.)-6.7 ( S)2 (ec)8.8 (ond ope)10.5 (r)-5.9 (at)-6.6 (i)2.6 (ons)-2 ( )11.3 (f)4.2 (or)-6 ( ")5.2 (c)-2 (om)-6 (pl)2.6 (et)-6.6 (i)2.6 (on)10.5 (")-5.7 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( i)2.6 (n )11.3 (t)-6.6 (r)-5.9 (ea)10.5 (t)-6.6 (m)-5.9 (e)10.5 (nt)-6.7 ( o)10.5 (f)-6.6 ( di)13.5 (f)-6.6 (f)-6.6 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed)10.6 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (.)-6.6 ( S)2 (u)10.5 (r)4.9 (g)-11.2 (er)-5.9 (y)8.8 ( )]TJ 0.002 Tw 0 -1.152 Td [(1991;)-6.6 (110:)-6.6 (936)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(939;)4.2 ( di)2.6 (s)-2 (c)-2 (u)10.5 (s)-2 (s)-2 (i)2.6 (on 939)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.141 0 Td [(940)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e)-11.2 ( at)4.2 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -15.576 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (1745981)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 303.84 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 301.8 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 280.2 Tm [(230.)-6.7 ( P)2 (as)-2 (i)2.6 (e)10.5 (k)-12.9 (a )11.2 (J)-2 (L,)4.3 ( )11.2 (T)-10.5 (hom)-6 (p)10.5 (s)-2 (on N)24.4 (W)-25.4 (,)4.3 ( M)15.7 (c)-2 (Leod M)15.7 (K)2 (,)-6.6 ( et)-6.6 ( )11.3 (al)2.7 (.)-6.7 ( )11.3 (T)-10.6 (he i)2.6 (nc)-2 (i)2.6 (denc)-2 (e o)10.6 (f)-6.7 ( )]TJ 0 -1.152 Td [(bi)2.6 (l)2.6 (at)-6.6 (er)-6 (al)2.6 ( w)13.5 (el)2.6 (l)]TJ 0 Tc 0 Tw 5.467 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(di)2.6 (f)-6.6 (f)-17.5 (er)-5.9 (en)10.6 (t)-6.7 (i)2.7 (at)-6.6 (e)10.5 (d t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )0.5 (c)-2.1 (anc)-2 (e)10.5 (r)-6 ( )11.3 (f)-6.6 (ound a)10.5 (t)4.3 ( c)-2 (om)-5.9 (pl)2.6 (e)10.6 (t)-6.7 (i)2.7 (on )]TJ -5.804 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 (.)-6.6 ( )33 (W)-36.3 (o)10.6 (r)-6 (l)2.6 (d)10.5 ( J)-2 ( S)12.9 (ur)4.9 (g)-11.2 ( 1992)10.5 (;)-6.6 (16:)-6.6 (711)]TJ 0 Tc 0 Tw 18.337 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(716;)4.2 ( di)2.6 (s)8.8 (c)-2 (us)-2 (s)-2 (i)2.6 (on )]TJ 0.002 Tw (716)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 9.141 0 Td [(717)10.5 (.)-6.6 ( )]TJ 0.007 Tw -27.815 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (1413840)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 690.6 242.16 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 240.12 222.48 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 218.52 Tm [(231.)-6.7 ( S)2 (c)-2 (heu)10.5 (m)-5.9 (ann )11.3 (G)-6.6 (F)11.2 (,)-6.6 ( S)1.9 (e)10.5 (el)2.6 (i)2.6 (g)-11.2 (er)-5.9 ( H)13.5 (,)-6.6 ( M)15.7 (us)-2 (hol)2.6 (t)-6.6 ( )11.3 (T)-10.6 (J)-2 (,)4.3 ( et)4.3 ( a)10.5 (l)2.6 (.)-6.6 ( C)2.6 (om)-6 (pl)2.6 (et)-6.6 (i)2.6 (on)10.5 ( )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( i)2.6 (n 131)10.5 ( pat)-6.6 (i)13.5 (ent)-6.7 (s)-2 ( )0.5 (w)13.4 (i)2.6 (t)-6.6 (h di)13.5 (f)-6.6 (f)-17.5 (e)10.6 (r)-6 (en)10.6 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.3 (t)-6.6 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a.)4.3 ( )]TJ -0.011 Tc 0.016 Tw [(E)-7 (u)-9.4 (r)-4.1 ( J )]TJ -0.002 Tc 0.007 Tw 0 -1.141 Td [(S)2 (ur)-5.9 (g 1996;)-6.6 (1)10.5 (62:)-6.6 (677)]TJ 0 Tc 0 Tw 8.478 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(684.)4.2 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -8.815 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8908447)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 180.6 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 178.56 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 156.96 Tm [(232.)-6.7 ( C)2.7 (hao )11.3 (T)-10.6 (C)13.5 (,)-6.6 ( J)8.9 (en)10.5 (g)-11.2 ( LB)1.9 (,)4.3 ( )11.3 (Li)2.6 (n J)-2 (D)2.6 (,)-6.6 ( C)2.6 (hen)10.5 ( M)15.8 (F.)-6.6 ( C)2.6 (om)-5.9 (pl)2.6 (et)-6.6 (i)2.6 (on t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (o)10.6 (m)-6 (y)8.9 ( )11.2 (f)-17.5 (o)10.6 (r)-6 ( )]TJ 0 -1.141 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (r)4.9 (c)-2 (i)2.6 (nom)-6 (a.)4.2 ( O)4.3 (t)-6.6 (ol)2.6 (ar)-5.9 (y)]TJ 17.663 0 Td [(ng)-11.3 (ol)2.6 ( H)2.6 (ea)10.5 (d N)2.6 (ec)8.9 (k)-12.9 ( S)1.9 (u)10.6 (r)4.9 (g)-11.2 ( )]TJ 0.002 Tw -17.663 -1.152 Td [(1998;)-6.6 (118:)-6.6 (896)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(899.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9627262)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 119.04 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 117 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 95.4 Tm [(233.)-6.7 ( P)2 (ac)-2 (i)2.6 (ni)2.6 ( F,)4.3 ( E)1.9 (l)2.7 (i)2.6 (s)-2 (ei)2.6 ( R)2.6 (,)-6.6 ( C)13.5 (apez)-2 (z)8.8 (one M)15.8 (,)-6.6 ( et)-6.6 ( al)2.6 (.)-6.6 ( C)2.6 (on)10.5 (t)-6.6 (r)5 (al)2.6 (at)-6.6 (er)-5.9 (al)2.6 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (anc)-2 (er)-6 ( i)2.6 (s)8.9 ( )11.3 (f)-6.7 (r)-5.9 (e)10.5 (q)-11.2 (uent)4.3 ( at)4.2 ( c)-2 (o)]TJ 10.359 0 Td [(m)-6 (pl)2.6 (et)-6.6 (i)2.7 (on )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( )11.3 (w)2.6 (i)2.6 (t)-6.6 (h no di)13.5 (f)-6.6 (f)-6.6 (er)-5.9 (enc)-2 (e)10.5 ( i)2.6 (n l)2.6 (ow)]TJ 0 Tc 0 Tw 21.152 0 Td (-)Tj 0.337 0 Td ( )Tj -0.002 Tc 0.007 Tw -31.848 -1.141 Td [(and hi)2.6 (g)-11.2 (h)]TJ 0 Tc 0 Tw 3.826 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(r)-6 (i)2.7 (s)8.8 (k)-2 ( pat)-6.6 (i)2.6 (ent)4.3 (s)-2 (.)4.3 ( )11.2 (Thy)8.9 (r)-6 (oi)2.6 (d 2001;)-6.6 (11:)-6.6 (877)]TJ 0 Tc 0 Tw 15 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(881.)4.2 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -19.5 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (11575858)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 57.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 55.44 228.72 0.84 re f EMC endstream endobj 1003 0 obj 26910 endobj %% Contents for page 116 %% Original object ID: 233 0 1004 0 obj << /Length 1005 0 R >> stream Q q BT /Xi114 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1005 0 obj 246 endobj %% Original object ID: 11705 0 1006 0 obj [ 2884 0 R 2885 0 R 2886 0 R 2887 0 R 2888 0 R 2889 0 R 2890 0 R 2891 0 R 2892 0 R 2893 0 R 2894 0 R 2895 0 R 2896 0 R 2897 0 R ] endobj %% Contents for page 117 %% Original object ID: 234 0 1007 0 obj << /Length 1008 0 R >> stream q endstream endobj 1008 0 obj 2 endobj %% Contents for page 117 %% Original object ID: 11706 0 1009 0 obj << /Length 1010 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (54)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(234.)-6.7 ( B)2 (ur)4.9 (g)-11.3 (e)10.6 ( M)15.8 (R)2.6 (,)-6.6 ( Zei)2.6 (s)-2 (e )11.3 (TM)15.8 (,)-6.6 ( J)-2 (ohns)-2 (en M)37.5 (W)-36.2 (,)4.2 ( et)4.2 ( al)2.6 (.)4.2 ( R)2.6 (i)2.7 (s)-2 (k)-12.9 (s)8.9 ( o)10.5 (f)-6.6 ( c)-2 (o)10.5 (m)-6 (pl)2.6 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (on )]TJ 0 -1.152 Td [(f)-6.6 (ol)2.7 (l)2.6 (ow)2.6 (i)2.6 (ng)-11.2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (dec)-2 (t)-6.6 (o)10.5 (m)-5.9 (y)8.8 (.)-6.6 ( )11.3 (J)-2 ( G)-6.6 (en)10.5 ( I)-6.5 (n)10.5 (t)-6.6 (e)10.5 (r)-6 (n M)15.8 (ed 1998;)-6.6 (1)10.5 (3:)-6.6 (24)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 24.217 0 Td [(31)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -24.217 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9462491)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 488.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 486.6 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 465 Tm [(235.)-6.7 ( D)2.7 (r)-6 (al)2.7 (l)2.6 (e H)13.5 (,)-6.6 ( )11.3 (G)]TJ 7.152 0 Td [(i)2.6 (m)4.9 (m)-5.9 ( )11.2 (O)-6.6 (,)4.3 ( )11.3 (S)1.9 (i)2.6 (m)-5.9 (on D)2.6 (,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( P)12.8 (r)-5.9 (ophy)8.9 (l)2.6 (ac)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( i)2.6 (n 75)10.5 ( )]TJ -7.152 -1.152 Td [(c)-2 (hi)2.6 (l)2.6 (dr)-5.9 (en and adol)2.6 (es)-2 (c)-2 (en)10.5 (t)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h her)-5.9 (edi)2.6 (t)-6.6 (ar)-5.9 (y)8.9 ( )11.2 (m)-5.9 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.6 (:)-6.7 ( )]TJ 0 -1.141 Td [(G)-6.6 (er)5 (m)-6 (an and)10.5 ( A)2 (us)8.9 (t)-6.6 (r)-5.9 (i)2.6 (an ex)8.9 (per)-6 (i)2.6 (enc)-2 (e.)-6.6 ( )33 (W)-36.3 (o)10.6 (r)-6 (l)2.6 (d)10.6 ( J)-2 ( S)2 (u)10.5 (r)4.9 (g)-11.2 ( 1)10.5 (998;)-6.6 (22:)-6.6 (744)]TJ 0 Tc 0 Tw 26.761 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(750;)4.2 ( )]TJ 0.007 Tw -27.098 -1.152 Td [(di)2.6 (s)-2 (c)-2 (us)-2 (s)-2 (i)2.6 (on 750)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 6.935 0 Td [(741)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.935 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9606292)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 412.32 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 390.72 Tm [(236.)-6.7 ( U)2.7 (del)2.6 (s)-2 (m)-6 (an)10.5 ( R)2.6 (,)4.3 ( La)10.5 (k)-12.8 (a)10.5 (t)4.3 (os)-2 ( E)2 (,)4.2 ( Ladens)-2 (on P)12.8 (.)-6.6 ( )11.3 (O)-6.6 (p)10.5 (t)-6.6 (i)2.6 (m)4.9 (al)2.6 ( s)-2 (ur)4.9 (g)-11.2 (er)-6 (y)8.9 ( )11.3 (f)-6.7 (or)4.9 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( )]TJ 0 -1.152 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a.)4.3 ( )22.2 (W)-36.3 (o)10.5 (r)-5.9 (l)2.6 (d)10.5 ( J)-2 ( S)2 (u)10.5 (r)4.9 (g)-11.2 ( 1996)10.6 (;)-6.7 (20:)-6.6 (88)]TJ 0 Tc 0 Tw 19.446 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(93.)4.3 ( A)12.8 (v)8.9 (ai)-8.2 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -19.783 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8588420)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 365.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 363.36 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 341.76 Tm [(237.)-6.7 ( P)2 (a)10.5 (t)-6.6 (t)-6.6 (ou)10.5 ( F,)4.2 ( C)2.7 (om)-5.9 (be)10.5 (m)4.9 (al)2.6 (e F,)-6.7 ( Fab)10.5 (r)-5.9 (e S)12.9 (,)-6.7 ( e)10.6 (t)-6.6 ( al)2.6 (.)4.3 ( H)2.6 (y)8.9 (poc)-2 (al)2.6 (c)-2 (em)-6 (i)2.6 (a )11.3 (f)-17.5 (ol)2.6 (l)2.6 (ow)13.5 (i)2.6 (ng)-11.3 ( )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d s)-2 (ur)5 (g)-11.3 (e)10.6 (r)-6 (y)8.9 (:)-6.7 ( )0.5 (i)2.6 (nc)-2 (i)2.6 (denc)-2 (e and p)10.5 (r)-5.9 (edi)2.6 (c)-2 (t)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( ou)10.6 (t)-6.6 (c)-2 (o)10.5 (m)-6 (e.)4.2 ( )22.2 (W)-36.3 (o)10.5 (r)-5.9 (l)2.6 (d)10.5 ( J)8.9 ( S)1.9 (ur)4.9 (g)-11.2 ( )]TJ 0.002 Tw 0 -1.152 Td [(1998;)-6.6 (22:)-6.6 (718)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(724.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.7 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9606288)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 303.84 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 301.8 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 280.2 Tm [(238.)-6.7 ( H)2.7 (as)-2 (s)-2 (anai)2.6 (n M)15.8 (,)-6.6 ( )33 (W)-36.3 (ex)8.9 (l)2.6 (er)-5.9 ( M)15.8 (.)-6.7 ( C)2.7 (ons)-2 (er)-5.9 (v)8.8 (at)-6.6 (i)2.6 (v)8.9 (e m)-5.9 (an)10.5 (ag)-11.2 (e)10.5 (m)-6 (ent)4.3 ( o)10.5 (f)-6.6 ( w)13.5 (el)2.6 (l)]TJ 0 Tc 0 Tw 28.348 0 Td (-)Tj -0.002 Tc 0.007 Tw -28.348 -1.152 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (an)10.5 (c)-2 (er)-6 (.)4.2 ( C)2.7 (an J)8.8 ( S)2 (ur)5 (g 2010;)-6.6 (53)10.5 (:)4.2 (109)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 23.989 0 Td [(118.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -23.989 -1.141 Td [(h)6.7 (ttp)]TJ -0.002 Tc 0.002 Tw 1.663 0 Td [(:)-6.6 (/)4.2 (/)-6.6 (w)2.7 (w)2.6 (w)13.4 (.)-6.6 (nc)-2 (bi)2.7 (.)-6.7 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.2 (gov)8.9 (/)-6.6 (pubm)-6 (ed/)-6.6 (20334743)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 254.88 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 252.84 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 231.24 Tm [(239.)-6.7 ( S)2 (os)-2 (a)10.5 ( J)-2 (A)1.9 (,)4.3 ( B)2 (ow)13.5 (m)-6 (an )11.3 (H)-8.3 (M)15.8 (,)-6.6 ( T)-10.6 (i)2.7 (el)2.6 (s)-2 (c)-2 (h)10.6 ( J)-2.1 (M)15.8 (,)-6.6 ( et)4.2 ( al)2.6 (.)-6.6 ( )11.3 (T)-10.6 (h)10.5 (e i)2.6 (m)-6 (por)4.9 (t)-6.6 (anc)-2 (e)10.6 ( o)10.5 (f)-6.6 ( s)-2 (ur)4.9 (g)-11.2 (eon)10.6 ( )]TJ 0 -1.152 Td [(ex)8.8 (per)-5.9 (i)2.6 (enc)-2 (e )11.3 (f)-17.5 (or)4.9 ( c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( and ec)-2 (onom)-6 (i)2.7 (c)8.8 ( out)-6.6 (c)-2 (o)10.6 (m)-6 (es)8.8 ( )11.3 (f)-6.6 (r)4.9 (om)-6 ( )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (dec)-2 (t)-6.6 (om)-5.9 (y)8.9 (.)4.2 ( A)2 (nn )]TJ 0 -1.141 Td [(S)2 (ur)-5.9 (g 1998;)-6.6 (2)10.5 (28:)-6.6 (320)]TJ 0 Tc 0 Tw 8.478 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(330.)4.2 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -8.815 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9742915)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 193.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 191.28 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 169.68 Tm [(240.)-6.7 ( R)2.7 (obbi)2.6 (ns)-2 ( R)2.6 (J)8.8 (,)-6.5 ( S)1.9 (c)-2 (hl)2.6 (u)10.5 (m)-6 (ber)5 (g)-11.3 (e)10.6 (r)-6 ( M)15.8 (J)-2 (.)-6.6 ( )11.3 (T)-10.6 (he)10.6 ( ev)8.9 (ol)2.6 (v)-2 (i)2.6 (n)-11.2 (g r)-6 (ol)2.6 (e )0.5 (o)10.5 (f)-6.6 ( )11.2 (\()-5.9 (131\))4.9 (I)-6.6 ( )11.3 (f)-6.6 (or)4.9 ( t)-6.6 (he)10.5 ( )]TJ 0 -1.152 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( di)13.4 (f)-6.5 (f)-6.6 (e)10.5 (r)-6 (ent)-6.6 (i)2.6 (at)-6.6 (e)10.5 (d t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (d c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.6 (.)-6.6 ( J)8.8 ( N)13.5 (uc)-2 (l)2.6 ( M)15.8 (ed 2005;)-6.7 (46 S)1.9 (uppl)2.6 ( )]TJ 0.002 Tw 0 -1.141 Td [(1:)-6.7 (28S)]TJ 0 Tc 0 Tw 2.609 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(37S)2 (.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 8.022 0 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (15653649)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 373.32 144.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 144.6 142.32 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 120.72 Tm [(241.)-6.7 ( Le)10.5 (g)-11.2 (e)10.5 (r)-5.9 ( FA)12.8 (,)-6.6 ( )11.3 (I)-6.6 (z)8.8 (em)-6 (bar)-5.9 (t)4.2 ( )11.3 (M)15.8 (,)-6.6 ( D)2.6 (ag)-11.2 (ous)-2 (s)-2 (et)4.2 ( F,)4.3 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( D)13.5 (ec)-2 (r)-6 (eas)-2 (ed up)10.5 (t)-6.6 (a)10.5 (k)-12.9 (e)10.6 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.152 Td [(t)-6.6 (her)-6 (apeu)10.5 (t)-6.6 (i)2.6 (c)-2 ( dos)-2 (es)8.8 ( )0.5 (o)10.5 (f)-6.6 ( i)2.6 (odi)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 12.25 0 Td [(131 a)10.5 (f)-6.6 (t)-6.6 (e)10.5 (r)-6 ( 185)]TJ 0 Tc 0 Tw 5.87 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(M)15.8 (B)1.9 (q)-11.2 ( i)2.6 (odi)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 5.315 0 Td [(131 di)2.6 (ag)-11.2 (no)10.5 (s)-2 (t)-6.6 (i)2.6 (c)-2 ( )]TJ -23.772 -1.141 Td [(i)2.6 (m)-5.9 (ag)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( )11.3 (f)-6.6 (o)10.5 (r)-6 ( )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d r)-6 (e)10.5 (m)-5.9 (n)10.5 (ant)-6.6 (s)-2 ( i)2.6 (n di)13.5 (f)-6.6 (f)-6.6 (e)10.5 (r)-5.9 (en)]TJ [(t)-6.7 (i)2.7 (at)-6.6 (ed)10.5 ( t)-6.6 (hy)8.9 (r)4.9 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( E)1.9 (u)10.6 (r)-6 ( J)8.9 ( )]TJ 0 -1.152 Td [(N)2.6 (uc)-2 (l)2.6 ( M)15.8 (ed 1998;)-6.6 (25:)-6.6 (242)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 10.37 0 Td [(2)10.5 (46.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -10.37 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9580856)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 70.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 68.04 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(242.)-6.7 ( M)15.8 (ur)-6 (at)-6.6 (et)4.3 ( J)-2 (P)1.9 (,)4.3 ( )11.3 (G)-6.6 (i)2.6 (r)-6 (aud )11.2 (P)2 (,)-6.6 ( D)2.6 (av)8.8 (er)-6 ( A)2 (,)4.2 ( et)4.2 ( al)2.6 (.)4.3 ( P)1.9 (r)-5.9 (edi)2.6 (c)-2 (t)4.2 (i)2.7 (ng)-11.2 ( )11.3 (t)-6.6 (he e)10.5 (f)-6.6 (f)-6.6 (i)2.6 (c)-2 (ac)-2 (y)8.9 ( o)10.5 (f)-6.6 ( )11.3 (f)-17.5 (i)13.5 (r)-6 (s)-2 (t)4.3 ( )]TJ -0.005 Tc 0.005 Tw 0 -1.152 Td [(io)-3.3 (d)-3.4 (in)]TJ 0 Tc 0 Tw 2.098 0 Td (e)Tj 0.554 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(131 t)-6.7 (r)-5.9 (ea)10.6 (t)4.2 (m)-5.9 (ent)4.2 ( i)2.7 (n d)10.5 (i)2.6 (f)-6.6 (f)-6.6 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.2 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-6 (a.)4.2 ( J)-2 ( N)2.6 (uc)-2 (l)13.5 ( M)15.8 (ed )]TJ 0.002 Tw -2.989 -1.141 Td [(1997;)-6.6 (38:)-6.6 (1362)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1368.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9293788)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 473.88 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 452.28 Tm [(243.)-6.7 ( C)2.7 (ooper)4.9 ( D)2.6 (S)1.9 (,)4.3 ( D)2.6 (oher)4.9 (t)4.3 (y)8.8 ( G)-6.6 (M)15.8 (,)-6.6 ( H)2.6 (aug)-11.2 (en B)1.9 (R)13.5 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( )11.3 (M)15.8 (anag)-11.3 (em)-6 (ent)]TJ 0 Tc 0 Tw 27.587 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.272 0 Td [(g)-11.2 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )]TJ 0.007 Tw -27.859 -1.141 Td [(f)-6.6 (or)5 ( pat)-6.7 (i)2.7 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d n)10.6 (odul)2.6 (es)-2 ( and di)13.5 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed)10.6 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-5.9 (.)4.2 ( )11.3 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0.002 Tw 0 -1.152 Td [(2006;)-6.6 (16:)-6.6 (109)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(142.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (16420177)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 412.32 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 390.72 Tm [(244.)-6.7 ( M)15.8 (az)-2 (z)8.8 (af)-17.5 (er)4.9 (r)-6 (i)2.7 ( E)1.9 (L.)4.2 ( C)2.6 (ar)-6 (c)8.9 (i)2.6 (nom)-5.9 (a o)]TJ 14.565 0 Td [(f)-6.6 ( )11.3 (f)-17.5 (ol)2.6 (l)2.7 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( epi)2.7 (t)-6.7 (hel)13.5 (i)2.6 (um)-6 (:)-6.6 ( R)2.6 (adi)2.6 (oi)2.6 (odi)2.6 (ne and )]TJ -14.565 -1.152 Td [(ot)-6.7 (her)5 ( t)4.2 (r)-5.9 (eat)4.2 (m)-5.9 (ent)4.2 ( out)4.2 (c)-2 (om)-6 (e)10.5 (s)-2 (.)-6.6 ( )11.3 (I)-6.6 (n:)4.3 ( B)2 (r)-6 (av)8.8 (er)-6 (m)-5.9 (an)10.6 ( LE)2 (,)4.2 ( U)2.6 (t)-6.6 (i)13.5 (g)-11.2 (e)10.5 (r)-6 ( R)2.6 (D)2.7 (,)4.2 ( eds)-2 (.)4.3 ( )11.3 (T)-10.6 (he)10.6 ( )11.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d:)-6.5 ( )]TJ 0 -1.141 Td [(A)2 ( Fundam)-6 (en)10.5 (t)-6.6 (al)2.7 ( and C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( T)-10.5 (ex)8.8 (t)4.3 (.)-6.6 ( P)1.9 (hi)2.6 (l)2.6 (adel)2.6 (phi)2.6 (a:)-6.6 ( Li)2.6 (ppi)2.6 (nc)-2 (ot)-6.6 (t)]TJ 0 Tc 0 Tw 25.217 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(R)2.6 (av)8.8 (en;)-6.6 ( )]TJ -25.554 -1.141 Td [(1996:)-6.6 (922)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 4.5 0 Td [(945)10.5 (.)]TJ 0 Tc 0 Tw 1.924 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -6.424 -2.141 Td [(245.)-6.7 ( A)12.9 (m)-6 (dur)4.9 ( R)2.6 (J)-2 (,)4.3 ( M)15.8 (a)-11.2 (z)8.8 (z)8.9 (af)-17.5 (er)-6 (r)-6 (i)2.6 ( E)2 (L)10.5 (.)-6.6 ( E)2 (s)-2 (s)-2 (en)10.5 (t)-6.6 (i)2.6 (al)2.6 (s)-2 ( o)10.5 (f)-6.6 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.7 (d C)2.6 (anc)-2 (er)-6 ( )]TJ 0.002 Tw 0 -1.152 Td [(M)15.8 (ana)]TJ 0.007 Tw [(g)-11.2 (em)-6 (ent)-6.6 (.)4.3 ( N)2.6 (ew)13.5 ( Y)2 (or)5 (k)-12.9 (:)4.2 ( S)2 (pr)-6 (i)2.6 (n)10.5 (g)-11.2 (er)4.9 ( S)1.9 (c)-2 (i)2.6 (enc)-1.9 (e;)-6.6 ( 2)10.5 (005.)]TJ 0 Tc 0 Tw 21.88 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -21.88 -2.141 Td [(246.)-6.7 ( S)2 (c)-2 (hl)2.6 (um)-5.9 (be)10.5 (r)5 (g)-11.3 (er)4.9 ( M)15.8 (J)-2 (,)-6.6 ( )11.2 (P)2 (ac)-2 (i)2.6 (ni)2.6 ( F.)-6.6 ( )11.3 (T)-10.6 (he l)2.6 (ow)13.5 ( ut)-6.6 (i)2.6 (l)2.6 (i)2.6 (t)-6.6 (y)8.9 ( of)-6.7 ( )0.5 (p)10.5 (r)-6 (et)-6.7 (he)10.5 (r)-5.9 (apy)8.9 ( s)-2.1 (c)-1.9 (ans)-2 ( i)2.6 (n)10.5 ( )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 ( pat)-6.6 (i)2.7 (en)10.5 (t)-6.6 (s)-2 (.)4.3 ( )11.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d 2009;)-6.6 (19)10.6 (:)-6.7 (815)]TJ 0 Tc 0 Tw 19.717 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(81)10.5 (6.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -20.054 -1.152 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)6.6 (l)9.6 (m)]TJ -0.002 Tc 0.002 Tw 8.641 0 Td [(.)-6.6 (ni)2.6 (h.)4.3 (gov)8.8 (/)-6.6 (pubm)-6 (ed/)-6.6 (19645614)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 267.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 265.44 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 243.84 Tm [(247.)-6.7 ( V)2 (an)10.5 ( N)2.6 (os)-2 (t)-6.6 (r)5 (and D)2.6 (,)4.3 ( A)1.9 (i)2.6 (k)-12.8 (en)10.5 ( )0.5 (M)15.7 (,)-6.6 ( A)2 (t)4.2 (k)-12.8 (i)2.6 (ns)-2 ( F)11.2 (,)-6.6 ( e)10.5 (t)-6.6 ( al)13.4 (.)-6.6 ( )11.3 (T)-10.6 (h)10.5 (e ut)-6.7 (i)2.7 (l)2.6 (i)2.6 (t)-6.6 (y)8.8 ( o)10.6 (f)-17.5 ( )11.3 (r)-6 (adi)2.6 (oi)2.6 (odi)2.6 (ne )]TJ 0 -1.141 Td [(s)-2 (c)-2 (ans)-2 ( p)10.5 (r)-5.9 (i)2.6 (or)-5.9 ( )11.3 (t)-6.7 (o i)2.6 (odi)2.6 (ne 131)10.5 ( )0.5 (abl)2.6 (at)-6.6 (i)2.6 (on i)2.6 (n pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h w)13.5 (e)-11.2 (l)2.6 (l)]TJ 0 Tc 0 Tw 23.478 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(di)2.6 (f)-6.6 (f)-17.5 (e)10.5 (r)-6 (ent)-6.5 (i)2.6 (at)-6.6 (e)10.5 (d t)-6.7 (hy)8.9 (r)-6 (oi)2.7 (d )]TJ -23.815 -1.152 Td [(c)-2 (anc)-2 (er)-6 (.)4.3 ( T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (2009;)-6.6 (19)10.5 (:)4.3 (849)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.022 0 Td [(855.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -13.022 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19281428)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 205.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 203.88 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 182.28 Tm [(248.)-6.7 ( S)2 (al)2.6 (v)8.8 (at)-6.6 (or)-5.9 (i)2.6 ( M)15.8 (,)-6.6 ( P)1.9 (er)-6 (o)10.5 (t)-6.6 (t)-6.6 (i)2.6 ( )11.3 (G)-6.6 (,)4.3 ( R)2.7 (u)10.5 (f)-17.5 (i)2.6 (ni)2.6 ( V)1.9 (,)4.3 ( et)4.3 ( al)2.6 (.)4.2 ( A)2 (r)-6 (e )11.2 (t)-6.6 (he)10.5 (r)-5.9 (e di)2.6 (s)-2 (adv)8.9 (ant)-6.6 (a)10.6 (g)-11.2 (es)-2 ( i)2.6 (n)10.5 ( )]TJ 0 -1.141 Td [(adm)-6 (i)2.7 (ni)2.6 (s)-2 (t)-6.6 (er)-6 (i)2.6 (n)10.5 (g)-11.2 ( 131)10.5 (I)-6.6 ( )0.5 (abl)2.7 (a)10.5 (t)-6.6 (i)2.6 (on t)-6.6 (he)10.6 (r)-6 (apy)8.9 ( i)2.6 (n pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)-6.7 (i)2.7 (at)-6.6 (e)10.5 (d )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( w)13.5 (i)2.6 (t)-6.6 (hout)-6.6 ( a p)10.5 (r)-6 (e)10.5 (abl)2.6 (at)-6.6 (i)2.6 (v)8.9 (e)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc -0.004 Tw 14.283 0 Td [(di)2.6 (ag)-11.2 (nos)-2 (t)-6.6 (i)2.6 (c)-2 ( )-10.6 (131)10.5 (I)-6.6 ( w)13.5 (ho)-11.2 (l)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.924 0 Td [(body)8.8 ( s)-2 (c)-2 (an? C)2.6 (l)2.6 (i)2.6 (n )]TJ -24.207 -1.141 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( \()4.9 (O)-6.6 (x)8.9 (f)-6.7 (\))-5.9 ( 2004)10.5 (;)-6.6 (61)10.6 (:)-6.7 (704)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.359 0 Td [(710)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -13.359 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (15579184)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 131.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 129.6 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 108 Tm [(249.)-6.7 ( H)2.7 (ay)8.9 ( I)-6.6 (D)2.6 (.)4.2 ( S)2 (el)2.7 (ec)-2 (t)-6.6 (i)2.6 (v)8.9 (e u)10.6 (s)-2 (e o)10.5 (f)-6.6 ( r)-5.9 (adi)2.6 (oac)8.8 (t)-6.6 (i)2.7 (v)8.8 (e i)2.6 (odi)2.6 (ne i)-8.2 (n t)-6.6 (he)10.6 ( pos)-2 (t)-6.6 (ope)10.5 (r)]TJ 0.002 Tw 27.761 0 Td [(at)-6.6 (i)2.6 (v)8.8 (e )]TJ 0.007 Tw -27.761 -1.141 Td [(m)-6 (ana)10.6 (g)-11.2 (em)-5.9 (en)10.5 (t)-6.6 ( o)10.6 (f)-6.7 ( )11.3 (pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( )11.3 (w)2.6 (i)2.6 (t)-6.6 (h papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( and )11.3 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)-8.2 (ar)-5.9 ( )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (a.)4.3 ( J)-2 ( )]TJ -0.004 Tw 0 -1.152 Td [(S)2 (ur)-5.9 (g O)-6.6 (nc)-2 (ol)2.6 ( )-10.6 (2006)10.6 (;)-6.6 (94:)-6.6 (692)]TJ 0 Tc 0 Tw 10.804 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(700.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -11.141 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (17131429)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 70.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 68.04 228.72 0.84 re f EMC endstream endobj 1010 0 obj 26052 endobj %% Contents for page 117 %% Original object ID: 235 0 1011 0 obj << /Length 1012 0 R >> stream Q q BT /Xi115 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1012 0 obj 246 endobj %% Original object ID: 11721 0 1013 0 obj [ 2898 0 R 2899 0 R 2900 0 R 2901 0 R 2902 0 R 2903 0 R 2904 0 R 2905 0 R 2906 0 R 2907 0 R 2908 0 R 2909 0 R 2910 0 R 2911 0 R 2912 0 R ] endobj %% Contents for page 118 %% Original object ID: 236 0 1014 0 obj << /Length 1015 0 R >> stream q endstream endobj 1015 0 obj 2 endobj %% Contents for page 118 %% Original object ID: 11722 0 1016 0 obj << /Length 1017 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (55)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(250.)-6.7 ( S)2 (aw)13.4 (k)-12.8 (a A)2 (M)15.8 (,)-6.6 ( B)1.9 (r)-6 (i)2.7 (er)-5.9 (l)2.6 (ey)8.9 ( J)-2 (D)2.6 (,)4.3 ( )11.2 (T)]TJ 13.576 0 Td [(s)-2 (an)10.5 (g)-11.2 ( R)35.2 (W)-36.3 (,)4.3 ( )11.3 (et)4.3 ( al)2.6 (.)-6.6 ( A)2 (n)10.5 ( updat)-6.6 (ed)10.5 ( s)-2 (y)8.8 (s)-2 (t)-6.6 (em)-6 (a)10.6 (t)-6.7 (i)2.6 (c)-2 ( )]TJ -13.576 -1.152 Td [(r)-6 (ev)8.9 (i)2.6 (e)-11.2 (w)13.4 ( and c)-2 (om)5 (m)-6 (ent)-6.6 (a)10.5 (r)-5.9 (y)8.8 ( ex)8.9 (am)-5.9 (i)2.6 (ni)2.6 (ng)-11.2 ( t)-6.6 (he)10.5 ( e)10.6 (f)-6.7 (f)-6.6 (ec)8.9 (t)-6.6 (i)2.6 (v)8.8 (en)-11.2 (es)-2 (s)-2 ( o)10.6 (f)-6.7 ( r)-5.9 (adi)2.6 (oac)8.9 (t)-6.6 (i)2.6 (v)8.8 (e i)2.6 (odi)2.6 (ne )]TJ 0 -1.141 Td [(r)-6 (em)-6 (nan)10.6 (t)-6.6 ( abl)2.6 (at)-6.6 (i)2.6 (on)10.5 ( i)2.6 (n w)13.4 (el)2.6 (l)]TJ 0 Tc 0 Tw 10.457 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.348 0 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (an)10.5 (c)-2 (er)-6 (.)4.2 ( E)2 (ndoc)-2 (r)-6 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab )]TJ -10.804 -1.152 Td [(C)2.6 (l)2.6 (i)2.6 (n N)2.6 (or)-5.9 (t)-6.6 (h A)2 (m)4.9 ( 2008)10.5 (;)-6.6 (37:)-6.6 (4)10.5 (57)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 12.359 0 Td [(480,)4.2 ( x)8.9 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -12.359 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (18502337)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 463.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 461.28 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 439.68 Tm [(251.)-6.7 ( S)2 (i)2.6 (s)-2 (s)-2 (on )11.3 (J)-2 (C)2.6 (,)-6.6 ( )11.3 (Fr)-6 (ei)2.6 (t)-6.6 (as)8.9 ( J)8.8 (,)-6.6 ( )0.5 (M)15.7 (c)-2 (D)2.6 (oug)-11.2 (al)2.6 (l)2.6 ( I)-6.6 (R)2.6 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( R)2.6 (adi)2.6 (at)-6.6 (i)2.6 (on s)-2 (a)10.5 (f)-17.5 (e)10.6 (t)-6.7 (y)8.9 ( i)2.6 (n t)-6.6 (he)10.5 ( )]TJ 0 -1.152 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (i)2.7 (t)-6.7 (h t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d di)2.6 (s)-2 (eas)-2 (es)8.9 ( by)8.9 ( r)-6 (ad)10.5 (i)2.6 (oi)2.6 (odi)2.6 (ne 131I)-6.7 ( :)4.3 ( pr)-6 (ac)8.9 (t)-6.6 (i)2.6 (c)-2 (e )]TJ 0 -1.141 Td [(r)-6 (ec)-2 (om)5 (m)-6 (enda)10.5 (t)-6.6 (i)2.6 (ons)-2 ( o)10.5 (f)-6.6 ( t)4.3 (he )11.3 (A)1.9 (m)-6 (er)-6 (i)2.6 (c)]TJ -0.004 Tw 14.076 0 Td [(an T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )-10.6 (A)1.9 (s)-1.9 (s)-2 (o)10.5 (c)-2 (i)2.6 (at)-6.6 (i)2.6 (on.)-6.6 ( T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0.002 Tw -14.076 -1.141 Td [(2011;)-6.6 (21:)-6.6 (335)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(346.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21417738)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 389.04 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 387 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 365.4 Tm [(252.)-6.7 ( M)15.8 (az)-2 (z)8.8 (af)-17.5 (er)4.9 (r)-6 (i)2.7 ( E)1.9 (L.)4.2 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d r)-6 (em)-6 (nan)10.6 (t)-6.6 ( 131)10.5 (I)4.3 ( abl)2.6 (at)-6.6 (i)2.6 (on )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( papi)2.6 (l)2.7 (l)2.6 (ar)-5.9 (y)8.8 ( and )]TJ 0 -1.141 Td [(f)-6.6 (ol)2.7 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (d c)]TJ -0.004 Tw 7.707 0 Td [(ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-6 (a.)4.2 ( T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (1997;)-6.6 (7)10.5 (:)-6.6 (265)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.565 0 Td [(271.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.7 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -21.272 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9133698)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 340.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 338.04 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 316.44 Tm [(253.)-6.7 ( )11.3 (T)-10.5 (ay)8.9 (l)2.6 (or)-5.9 ( )11.3 (T)-10.6 (,)4.2 ( S)2 (pec)8.9 (k)-12.9 (e)10.5 (r)-5.9 ( B)12.8 (,)-6.6 ( R)2.6 (obbi)2.6 (ns)-2 ( J)8.9 (,)-6.6 ( e)10.5 (t)4.3 ( al)2.6 (.)-6.6 ( )11.3 (O)-6.6 (ut)4.3 (c)-2 (o)10.5 (m)-5.9 (e a)10.5 (f)-6.6 (t)-6.6 (e)10.5 (r)-5.9 ( )11.3 (t)-6.7 (r)-5.9 (ea)10.6 (t)-6.7 (m)-5.9 (e)10.5 (nt)4.2 ( o)10.6 (f)-6.7 ( )]TJ -0.005 Tc 0.005 Tw 0 -1.141 Td [(h)-3.3 (ig)-14.3 (h)]TJ 0 Tc 0 Tw 1.891 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(r)-6 (i)2.7 (s)8.8 (k)-12.8 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( and no)10.5 (n)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 9.75 0 Td [(H)2.6 (ur)-6 (t)-6.6 (hl)]TJ 0 Tc 0 Tw 2.663 0 Td (e)Tj 0.554 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(c)-2 (el)2.6 (l)2.6 ( )11.2 (f)-17.4 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( t)-6.6 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-1.9 (i)2.5 (nom)-6 (a.)4.2 ( A)2 (nn )]TJ -15.511 -1.152 Td [(I)-6.6 (nt)-6.6 (e)10.6 (r)-6 (n M)15.7 (ed 1998;)-6.5 (129:)-6.6 (6)10.5 (2)10.5 (2)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 11.467 0 Td [(627.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -11.467 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9786809)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 278.52 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 276.48 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 254.88 Tm [(254.)-6.7 ( R)2.7 (uel)2.6 ( E)1.9 (,)4.3 ( )11.3 (T)-10.6 (ho)10.6 (m)-6 (as)-2 ( S)12.8 (,)-6.6 ( )11.2 (D)2.7 (i)2.6 (nan M)15.8 (,)-6.6 ( et)-6.7 ( al)2.6 (.)-6.6 ( A)2 (d)10.5 (j)-8.3 (uv)8.8 (ant)-6.6 ( )11.3 (r)-6 (adi)2.6 (oac)-2 (t)-6.6 (i)2.6 (v)8.8 (e i)2.6 (odi)2.6 (ne )]TJ 0 -1.152 Td [(t)-6.6 (her)-6 (apy)8.9 ( i)2.6 (s)-2 ( as)-2 (s)-2 (o)10.5 (c)-2 (i)2.6 (at)-6.6 (ed w)13.4 (i)2.6 (t)-6.6 (h i)2.6 (m)-6 (pr)-5.9 (ov)8.9 (ed s)-2 (u)10.5 (r)-6 (v)8.9 (i)2.6 (v)8.9 (a)-11.2 (l)2.6 ( f)-17.5 (o)10.5 (r)-5.9 ( p)10.5 (at)-6.6 (i)2.6 (ent)-6.5 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h i)2.6 (nt)-6.6 (e)10.5 (r)-5.9 (m)-6 (edi)2.6 (at)-6.6 (e)]TJ 0 Tc 0 Tw 32.467 0 Td (-)Tj -0.002 Tc 0.007 Tw -32.467 -1.141 Td [(r)-6 (i)2.7 (s)-2 (k)-2 ( papi)2.6 (l)2.6 (l)2.7 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (an)10.6 (c)-2 (er)-6 (.)4.3 ( J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)2 (ndoc)8.9 (r)-6 (i)2.6 (nol)2.7 ( M)15.7 (e)-11.2 (t)-6.6 (ab 2015)10.5 (;)-6.6 (100:)-6.6 (1529)]TJ 0 Tc 0 Tw 30.076 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(1536)10.5 (.)-6.6 ( )]TJ 0.007 Tw -30.413 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)13.5 (w)2.6 (w)-8.3 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)4.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-6 (e)10.5 (d/)-6.6 (25642591)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 320.88 216.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 214.92 234.239 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 193.32 Tm [(255.)-6.7 ( J)-2 (on)10.5 (k)-12.9 (l)2.7 (aas)8.8 ( J)8.9 (,)-6.6 ( S)2 (ar)-6 (l)2.7 (i)2.6 (s)-2 ( N)13.5 (J)-2.1 (,)-6.6 ( Li)2.6 (t)-6.6 (o)10.5 (f)-6.6 (s)8.9 (k)-12.9 (y)8.9 ( D)2.6 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( O)-6.6 (u)10.5 (t)-6.6 (c)-2 (o)10.5 (m)-5.9 (es)-2 ( o)10.5 (f)-6.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (i)2.6 (t)-6.6 (h )]TJ -0.004 Tw 0 -1.152 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d )-10.6 (c)-2 (a)10.5 (r)5 (c)-2.1 (i)2.7 (nom)-6 (a f)-6.6 (ol)2.6 (l)2.6 (ow)2.6 (i)2.6 (ng)-11.2 ( )-10.6 (i)2.6 (ni)2.6 (t)-6.6 (i)2.6 (al)2.6 ( )-10.6 (t)-6.6 (h)10.5 (er)-6 (apy)8.9 (.)-6.6 ( T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0.002 Tw 0 -1.141 Td [(2006;)-6.6 (16:)-6.6 (1229)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1242.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)]TJ 0 Tc 0 Tw 8.196 0 Td ( )Tj EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw -14.63 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (17199433)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 155.28 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 153.24 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 131.64 Tm [(256.)-6.7 ( J)-2 (on)10.5 (k)-12.9 (l)2.7 (aas)8.8 ( J)8.9 (,)-6.6 ( C)2.6 (ooper)4.9 ( )11.3 (D)2.6 (S)2 (,)-6.6 ( A)1.9 (i)2.6 (n K)1.9 (B)2 (,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( R)2.6 (adi)2.6 (oi)2.6 (odi)2.6 (ne t)-6.6 (her)-5.9 (apy)8.8 ( i)2.6 (n pa)10.6 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( )]TJ 0 -1.141 Td [(w)2.6 (i)2.6 (t)-6.6 (h s)-2 (t)-6.7 (a)10.6 (g)-11.2 (e)10.5 ( I)4.2 ( di)13.5 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( t)-6.5 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (e)10.6 (r)-6 (.)4.3 ( )11.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )11.3 (2010;)-6.6 (20:)-6.6 (1423)]TJ 0 Tc 0 Tw 27.859 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(1424.)4.3 ( )]TJ -0.011 Tc 0.011 Tw -28.196 -1.152 Td [(A)-7 (va)-9.3 (i)]TJ -0.002 Tc 0.007 Tw 1.935 0 Td [(l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.3 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (pub)10.5 (m)-6 (ed)10.5 (/)-6.6 (21054207)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 106.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 104.28 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 82.68 Tm [(257.)-6.7 ( )11.3 (I)-6.6 (y)8.9 (er)-5.9 ( N)2.6 (G)4.2 (,)-6.6 ( M)15.8 (or)-6 (r)-5.9 (i)2.6 (s)-2 ( L)10.5 (G)4.2 (,)4.3 ( )11.3 (T)-10.6 (ut)4.2 (t)-6.6 (l)2.6 (e R)2.6 (M)15.8 (,)-6.6 ( et)-6.6 ( al)13.4 (.)-6.6 ( R)2.6 (i)2.6 (s)-2 (i)2.7 (ng i)2.6 (nc)-2 (i)2.6 (denc)-2 (e )0.5 (o)10.5 (f)-6.6 ( s)-1.9 (ec)-2 (ond)10.5 ( )]TJ 0 -1.141 Td [(c)-2 (anc)-2 (er)-6 (s)8.9 ( i)2.6 (n pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h l)2.6 (ow)]TJ 0 Tc 0 Tw 12.12 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(r)-6 (i)2.7 (s)-2 (k)-12.9 ( )11.2 (\()5 (T)-10.6 (1N)2.7 (0\))4.9 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)8.9 (anc)-2 (er)-5.9 ( w)13.5 (ho r)-5.9 (ec)-2 (ei)2.6 (v)8.9 (e )]TJ 0.002 Tw -12.457 -1.141 Td [(r)-6 (ad)]TJ 0.007 Tw [(i)2.7 (oac)-2 (t)-6.6 (i)2.6 (v)8.8 (e i)2.6 (odi)2.6 (ne t)-6.6 (her)-5.9 (ap)10.5 (y)8.9 (.)-6.6 ( C)2.6 (anc)-2 (er)-6 ( 2011)10.5 (;)-6.6 (117:)-6.6 (443)10.6 (9)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 22.391 0 Td [(4446.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.391 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21432843)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 44.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 42.72 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(258.)-6.7 ( H)2.7 (ay)8.9 ( I)-6.6 (D)2.6 (,)4.2 ( )11.3 (T)-10.6 (ho)10.5 (m)-5.9 (ps)-2 (on )11.3 (G)-6.6 (B)1.9 (,)4.3 ( G)4.3 (r)-6 (ant)4.3 ( C)2.6 (S)1.9 (,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( P)1.9 (ap)10.5 (i)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a )]TJ -0.004 Tw 0 -1.152 Td [(m)-6 (ana)10.6 (g)-11.2 (ed )-10.6 (a)10.5 (t)-6.6 ( t)-6.6 (he)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 7.217 0 Td [(M)15.8 (ay)8.9 (o )0.5 (C)2.6 (l)2.6 (i)-8.3 (ni)2.6 (c)-2 ( dur)-6 (i)2.6 (n)10.6 (g)-11.3 ( s)-2 (i)2.6 (x)8.9 ( dec)-2 (ades)-2 ( )11.3 (\()-6 (1)10.5 (940)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 16.88 0 Td [(1999\))4.9 (:)-6.6 ( t)-6.6 (em)-5.9 (po)10.5 (r)-5.9 (al)2.7 ( )]TJ 0.007 Tw -24.098 -1.141 Td [(t)-6.6 (r)-6 (ends)8.9 ( i)2.6 (n i)2.6 (ni)2.6 (t)-6.6 (i)2.6 (al)2.7 ( t)-6.6 (he)10.5 (r)-5.9 (apy)8.9 ( and l)2.6 (ong)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.413 0 Td [(t)-6.6 (e)10.5 (r)-5.9 (m)4.9 ( out)4.2 (c)-2 (om)-6 (e)10.6 ( i)2.7 (n )11.3 (2444 c)-2 (ons)-2 (ec)-2 (u)10.6 (t)-6.6 (i)2.6 (v)8.8 (el)-8.3 (y)8.9 ( )]TJ -14.413 -1.152 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (ed pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 (.)-6.5 ( )33 (W)-36.3 (o)10.5 (r)-5.9 (l)2.6 (d J)8.9 ( )11.3 (S)1.9 (ur)-6 (g 2002;)-6.6 (2)10.5 (6:)-6.6 (879)]TJ 0 Tc 0 Tw 19 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(885.)4.2 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -19.337 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)]TJ -0.002 Tc 0.002 Tw 4.641 0 Td [(.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.7 (m)-6 (.)-6.6 (ni)2.7 (h.)4.3 (gov)8.8 (/)-6.5 (pubm)-6 (ed/)-6.6 (12016468)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 463.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 461.28 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 439.68 Tm [(259.)-6.7 ( H)2.7 (u )11.3 (G)4.2 (,)-6.6 ( Zhu)10.5 ( )22.1 (W)-25.4 (,)4.3 ( Y)2 (an)10.6 (g )22.1 (W)-25.3 (,)4.2 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( )11.3 (T)-10.6 (he )0.5 (E)12.8 (f)-6.6 (f)-6.6 (e)10.5 (c)-2 (t)-6.6 (i)2.6 (v)8.8 (enes)-2 (s)-2 ( o)10.5 (f)-6.6 ( R)2.6 (adi)2.7 (oac)-2 (t)-6.6 (i)2.7 (v)8.8 (e I)-6.6 (odi)2.6 (n)10.5 (e )]TJ 0 -1.152 Td [(R)2.6 (em)-6 (nant)4.2 ( A)2 (bl)2.7 (at)-6.6 (i)2.6 (on )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( P)1.9 (a)10.5 (pi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( T)-10.6 (hy)8.9 (r)-6 (oi)2.7 (d M)4.9 (i)2.6 (c)-2 (r)-5.9 (oc)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a:)4.3 ( A)2 ( S)1.9 (y)8.9 (s)-2 (t)-6.6 (em)5 (at)-6.6 (i)2.6 (c)-2 ( )]TJ 0 -1.141 Td [(R)2.6 (ev)8.8 (i)2.6 (e)-11.2 (w)13.5 ( and )-10.5 (M)15.8 (et)-6.6 (a)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 8.033 0 Td [(anal)2.6 (y)8.9 (s)-12.9 (i)2.6 (s)-2 (.)-6.6 ( )22.1 (W)-36.3 (o)10.6 (r)-6 (l)2.6 (d)10.6 ( J)8.8 ( S)2 (ur)4.9 (g 2016;)-6.6 (40)10.5 (:)-6.6 (100)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 16.076 0 Td [(109)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -24.109 -1.141 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (26578322)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 639.24 401.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 399.72 234.24 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 378 Tm [(260.)-6.7 ( S)2 (c)-2 (hv)8.8 (ar)-6 (t)-6.6 (z)8.9 ( C)2.6 (,)4.3 ( B)2 (onnet)4.3 (ai)2.6 (n F,)-6.6 ( D)2.6 (aba)10.5 (k)-12.8 (uy)8.9 (o S)2 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( I)4.2 (m)-5.9 (pac)-2 (t)4.3 ( on)10.5 ( ov)8.9 (er)-5.9 (al)2.6 (l)2.6 ( )]TJ 0 -1.141 Td [(s)-2 (ur)-6 (v)8.9 (i)2.6 (v)8.9 (a)-11.3 (l)2.6 ( of)-6.6 ( r)-6 (adi)2.7 (oac)8.9 (t)-6.6 (i)2.6 (v)8.9 (e i)2.6 (odi)2.6 (ne i)2.6 (n l)2.6 (ow)]TJ 0 Tc 0 Tw 15.326 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(r)-6 (i)2.7 (s)-2 (k)-12.9 ( di)13.5 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.6 (t)-6.6 (i)13.4 (at)-6.6 (ed )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2.1 (er)4.9 ( )]TJ -15.663 -1.141 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 (.)4.3 ( J)8.8 ( C)2.6 (l)2.7 (i)2.6 (n E)2 (n)]TJ [(doc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2012;)-6.6 (97:)-6.6 (1526)]TJ 0 Tc 0 Tw 20.946 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1)10.5 (535.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -21.283 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22344193)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 340.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 338.04 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 316.44 Tm [(261.)-6.7 ( H)2.7 (au)10.5 (g)-11.2 (en)10.5 ( B)1.9 (R)2.7 (.)-6.7 ( R)2.7 (adi)2.6 (oi)2.6 (odi)2.5 (ne r)-6 (em)-5.9 (nan)10.5 (t)-6.6 ( abl)2.6 (a)10.6 (t)-6.7 (i)2.7 (on:)-6.6 ( )11.2 (c)-2 (ur)-6 (r)-5.9 (en)10.5 (t)-6.6 ( i)2.6 (ndi)2.6 (c)-2.1 (at)-6.6 (i)2.6 (ons)8.9 ( and )]TJ 0 -1.141 Td [(dos)-2 (i)2.6 (ng)-11.2 ( )11.2 (r)-5.9 (e)10.5 (g)-11.2 (i)2.6 (m)-6 (ens)8.9 (.)-6.6 ( E)1.9 (ndoc)8.9 (r)4.9 ( P)2 (r)-6 (ac)8.9 (t)-6.6 ( 201)]TJ 0.002 Tw [(2)10.5 (;)-6.6 (18:)-6.6 (604)]TJ 0 Tc 0 Tw 19.446 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(610.)4.2 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -19.783 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22849876)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 291.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 289.08 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 267.48 Tm [(262.)-6.7 ( C)2.7 (as)8.9 (t)-6.6 (a)10.5 (g)-11.2 (na M)15.8 (G)-6.6 (,)4.2 ( C)2.6 (ev)8.9 (eni)2.6 (ni)2.6 ( G)-6.6 (,)4.3 ( )11.2 (T)-10.5 (heodor)-6 (opoul)2.6 (ou)10.5 ( A)2 (,)-6.7 ( e)10.6 (t)4.2 ( al)2.6 (.)-6.6 ( P)1.9 (os)8.8 (t)]TJ 0 Tc 0 Tw 27.587 0 Td (-)Tj -0.005 Tc 0.005 Tw 0.337 0 Td [(s)-5 (u)7.5 (r)1.9 (g)-14.2 (ic)-5 (a)-3.3 (l )]TJ -0.002 Tc 0.007 Tw -27.924 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d abl)2.6 (at)-6.6 (i)2.7 (on w)13.5 (i)2.6 (t)-6.6 (h l)2.6 (ow)13.5 ( )-10.5 (or)-6 ( hi)13.5 (g)-11.2 (h )11.3 (r)-6 (adi)2.6 (oi)2.6 (odi)2.6 (ne ac)-2 (t)-6.6 (i)2.6 (v)8.8 (i)2.7 (t)-6.7 (i)]TJ -0.005 Tc 0.01 Tw 22.098 0 Td [(e)-3.3 (s)-5.1 ( r)-8.9 (e)-3.4 (s)-5 (u)-3.4 (lt)-9.7 (s)5.9 ( in)-3.4 ( s)-5 (im)-9 (ila)-3.4 (r)1.9 ( )]TJ -0.002 Tc 0.007 Tw -22.098 -1.152 Td [(out)-6.6 (c)-2 (om)-6 (e)10.5 (s)-2 ( i)2.6 (n i)2.6 (nt)-6.6 (e)10.6 (r)4.9 (m)-6 (edi)2.6 (at)4.2 (e r)-6 (i)2.6 (s)8.9 (k)-2 ( di)13.5 (f)-6.7 (f)-17.4 (e)10.5 (r)-6 (ent)-6.6 (i)2.6 (at)-6.6 (ed)10.6 ( )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.8 (.)4.3 ( E)2 (ur)-5.9 ( )11.2 (J)-2 ( )]TJ 0 -1.141 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( 2013;)-6.6 (169)10.5 (:)-6.6 (23)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 10.859 0 Td [(29.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -10.859 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (23594687)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 216.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 214.92 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 193.32 Tm [(263.)-6.7 ( C)2.7 (l)2.6 (em)-5.9 (en)10.6 (t)]TJ 0 Tc 0 Tw 5.935 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(S)2 (C)2.6 (,)4.2 ( P)2 (eet)-6.6 (e)10.5 (r)4.9 (s)-2 ( R)2.6 (P)2 (,)-6.6 ( R)2.6 (onc)8.9 (k)-2 (er)-5.9 (s)8.8 ( C)2.6 (M)15.8 (,)-6.6 ( et)-6.7 ( )0.5 (a)10.5 (l)2.6 (.)-6.6 ( I)-6.6 (n)10.5 (t)-6.6 (er)5 (m)-6 (edi)2.6 (at)-6.6 (e)10.5 ( and l)2.6 (on)10.5 (g)]TJ 0 Tc 0 Tw 26.25 0 Td (-)Tj -0.002 Tc 0.007 Tw -32.467 -1.152 Td [(t)-6.6 (er)5 (m)-6 ( adv)8.9 (er)-5.9 (s)-2 (e)10.5 ( e)10.5 (f)-6.6 (f)-6.6 (ec)-2 (t)4.2 (s)-2 ( o)10.5 (f)-6.6 ( )11.3 (r)4.9 (adi)2.6 (oi)2.6 (odi)2.6 (ne t)-6.6 (her)-5.9 (apy)8.8 ( )11.3 (f)-17.5 (or)4.9 ( di)13.5 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.6 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ 0.002 Tw 0 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)]TJ 0.004 Tc -0.004 Tw 4.598 0 Td (--)Tj -0.002 Tc 0.007 Tw [(a)10.5 ( s)-2 (y)8.9 (s)-2 (t)-6.6 (em)-5.9 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (r)-6 (ev)8.9 (i)2.6 (e)-11.2 (w)13.5 (.)-6.6 ( C)2.6 (anc)-2 (er)-5.9 ( )11.3 (Tr)-6 (eat)4.3 ( R)2.6 (e)10.5 (v)8.9 ( 2015;)-6.6 (41:)-6.6 (925)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 23.935 0 Td [(934)10.5 (.)-6.6 ( )]TJ 0.007 Tw -28.533 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)13.5 (w)2.6 (w)-8.3 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)4.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-6 (e)10.5 (d/)-6.6 (26421813)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 702.36 155.28 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 153.24 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 131.64 Tm [(264.)-6.7 ( B)2 (r)-6 (i)2.7 (e)10.5 (r)-6 (l)2.6 (ey)8.9 ( J)-2.1 (,)-6.5 ( M)15.7 (ax)8.8 (on H)-8.3 (R)2.6 (.)-6.6 ( R)2.6 (adi)2.6 (oi)2.6 (odi)2.6 (ne and ex)8.9 (t)-6.6 (er)4.9 (nal)2.7 ( r)-6 (adi)2.6 (at)-6.6 (i)2.6 (on )11.2 (t)-6.6 (her)-6 (apy)8.9 ( i)2.6 (n )]TJ 0 -1.141 Td [(t)-6.6 (he )11.3 (t)-6.6 (r)-6 (ea)10.6 (t)-6.6 (m)-6 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)8.9 (anc)-2 (er)-6 (.)4.3 ( I)-6.6 (n)10.5 (:)-6.6 ( Fa)10.5 (g)-11.2 (i)2.6 (n)10.5 ( J)-2 (A)2 (,)4.2 ( ed.)4.3 ( )11.3 (T)-10.6 (hy)8.9 (r)-5.9 (oi)2.6 (d C)2.6 (anc)-2 (er)5 (.)-6.6 ( )]TJ 0 -1.152 Td [(B)2 (os)-2 (t)-6.6 (on/)-6.6 (D)2.6 (or)-6 (d)10.5 (r)-5.9 (ec)-2 (h)10.6 (t)-6.6 (/)-6.7 (Londo)10.6 (n:)-6.6 ( K)2 (l)2.6 (uw)13.5 (er)-6 ( A)2 (c)-2 (adem)-5.9 (i)2.6 (c)-2 (;)4.2 ( )0.5 (199)10.5 (8:)-6.6 (285)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 24.663 0 Td [(317)10.5 (.)]TJ 0 Tc 0 Tw 1.924 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -26.587 -2.141 Td [(265.)-6.7 ( H)2.7 (ans)-2 (c)-2 (hei)2.6 (d H)13.5 (,)-6.6 ( La)10.6 (s)-2 (s)8.8 (m)-5.9 (ann )0.5 (M)15.7 (,)-6.6 ( Lus)8.9 (t)-6.6 (er)5 ( M)15.7 (,)-6.6 ( et)-6.6 ( al)13.5 (.)-6.6 ( )11.3 (B)1.9 (l)2.6 (ood dos)-2 (i)2.6 (m)-6 (et)4.3 (r)-6 (y)8.9 ( )11.2 (f)-17.4 (r)-6 (o)10.5 (m)-5.9 ( a)10.5 ( )]TJ 0 -1.141 Td [(s)-2 (i)2.6 (ng)-11.3 (l)2.7 (e )11.3 (m)-6 (eas)-2 (ur)-6 (e)10.6 (m)-6 (en)10.6 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.2 (t)4.3 (he w)13.5 (hol)2.6 (e body)8.9 ( r)-6 (adi)2.6 (oi)2.6 (odi)2.6 (n)-11.2 (e r)-6 (e)10.5 (t)-6.6 (ent)-6.6 (i)2.6 (on i)2.6 (n )11.3 (pat)-6.6 (i)2.7 (ent)-6.6 (s)8.8 ( )]TJ 0 -1.141 Td [(w)2.6 (i)2.6 (t)-6.6 (h di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.7 (no)10.5 (m)-5.9 (a.)4.3 ( E)2 (ndoc)-2 (r)4.9 ( R)2.6 (el)2.6 (at)-6.6 ( C)2.6 (anc)-2 (e)10.6 (r)-6 ( 2009)10.5 (;)-6.6 (16:)-6.6 (1283)]TJ 0 Tc 0 Tw 32.13 0 Td (-)Tj -0.002 Tc 0.007 Tw -32.13 -1.152 Td [(1289.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.3 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.7 (nc)-2 (bi)2.6 (.)-6.7 (nl)2.6 (m)-5.9 (.)-6.7 (ni)2.6 (h.)-6.6 (g)-11.3 (ov)8.9 (/)-6.7 (pu)10.5 (bm)-6 (ed/)-6.6 (19628649)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 727.32 44.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 498.72 42.72 228.6 0.84 re f EMC endstream endobj 1017 0 obj 29029 endobj %% Contents for page 118 %% Original object ID: 237 0 1018 0 obj << /Length 1019 0 R >> stream Q q BT /Xi116 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1019 0 obj 246 endobj %% Original object ID: 11738 0 1020 0 obj [ 2913 0 R 2914 0 R 2915 0 R 2916 0 R 2917 0 R 2918 0 R 2919 0 R 2920 0 R 2921 0 R 2922 0 R 2923 0 R 2924 0 R 2925 0 R 2926 0 R ] endobj %% Contents for page 119 %% Original object ID: 238 0 1021 0 obj << /Length 1022 0 R >> stream q endstream endobj 1022 0 obj 2 endobj %% Contents for page 119 %% Original object ID: 11739 0 1023 0 obj << /Length 1024 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (56)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(266.)-6.7 ( )11.3 (T)-10.5 (u)10.5 (t)-6.6 (t)-6.6 (l)2.6 (e R)2.6 (M)15.8 (,)-6.6 ( Leboeu)10.5 (f)-6.6 ( )11.3 (R)2.6 (,)-6.7 ( )0.5 (R)2.6 (obbi)2.6 (ns)-2 ( R)2.6 (J)8.9 (,)-6.7 ( e)10.6 (t)-6.6 ( al)2.6 (.)4.3 ( E)1.9 (m)5 (pi)2.6 (r)-5.9 (i)2.6 (c)-2 ( r)-6 (adi)2.6 (oac)-2 (t)-6.6 (i)2.6 (v)8.9 (e i)2.7 (odi)2.6 (ne )]TJ 0 -1.152 Td [(dos)-2 (i)2.6 (ng)-11.2 ( )11.2 (r)-5.9 (e)10.5 (g)-11.2 (i)2.6 (m)-6 (ens)8.9 ( )11.3 (f)-6.6 (r)-6 (e)10.5 (q)-11.2 (uen)10.5 (t)-6.6 (l)2.6 (y)8.9 ( ex)8.8 (c)-2 (eed m)-6 (ax)8.9 (i)2.6 (m)-6 (um)-6 ( )11.3 (t)-6.6 (ol)2.6 (er)-6 (at)-6.6 (ed)10.5 ( )0.5 (ac)-2 (t)-6.6 (i)2.6 (v)8.9 (i)2.6 (t)-6.6 (y)8.8 ( l)2.6 (ev)8.9 (e)-11.2 (l)2.6 (s)-2 ( i)2.6 (n )]TJ 0 -1.141 Td [(el)2.6 (der)-6 (l)2.6 (y)8.9 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (hy)8.8 (r)5 (oi)2.6 (d)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 12.293 0 Td [(c)-2 (anc)-2 (er)4.9 (.)-6.6 ( J)8.8 ( N)2.6 (uc)-2 (l)2.6 ( M)15.8 (ed 2006;)-6.6 (47:)-6.6 (1587)]TJ 0 Tc 0 Tw 14.902 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(1591.)4.3 ( )]TJ 0.007 Tw -27.533 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (17015892)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 473.88 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 452.28 Tm [(267.)-6.7 ( V)2 (an)10.5 ( N)2.6 (os)-2 (t)-6.6 (r)5 (and D)2.6 (,)4.3 ( )22.1 (W)-14.5 (ar)-5.9 (t)-6.6 (o)10.5 (f)-6.6 (s)8.9 (k)-12.9 (y)8.9 ( L.)4.3 ( R)2.6 (adi)2.6 (oi)2.6 (odi)2.6 (ne i)2.6 (n t)-6.6 (he)10.5 ( t)4.3 (r)-6 (eat)4.3 (m)-6 (ent)4.3 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.141 Td [(c)-2 (anc)-2 (er)-6 (.)4.3 ( E)1.9 (ndoc)-2 (r)-6 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 11.587 0 Td [(C)2.6 (l)2.6 (i)2.6 (n N)2.6 (or)-5.9 (t)-6.6 (h)10.5 ( A)2 (m)4.9 ( 2007;)-6.6 (36)10.6 (:)-6.6 (807)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 12.359 0 Td [(822)10.5 (,)-6.6 ( v)8.9 (i)2.6 (i)]TJ 0 Tc 0 Tw 3.141 0 Td (-)Tj -0.005 Tc 0.005 Tw 0.337 0 Td [(v)5.9 (i)-11.3 (ii.)-9.6 ( )]TJ -0.002 Tc 0.007 Tw -27.424 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (17673129)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 426.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 424.92 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 403.32 Tm [(268.)-6.7 ( Las)-1.9 (s)8.8 (m)-5.9 (ann)10.5 ( M)15.8 (,)-6.6 ( R)2.6 (ei)2.6 (ner)-5.9 (s)-2 ( C)2.6 (,)4.3 ( Lus)8.8 (t)-6.6 (er)4.9 ( M)15.8 (.)-6.6 ( D)2.6 (os)-2 (i)2.6 (m)-5.9 (et)4.3 (r)4.9 (y)8.9 ( and t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (d c)-2 (anc)-2 (er)4.9 (:)4.2 ( t)-6.6 (he)10.5 ( )]TJ 0 -1.141 Td [(i)2.6 (ndi)-8.2 (v)8.8 (i)2.6 (dual)2.6 ( dos)-2 (ag)-11.2 (e o)10.5 (f)-6.6 ( )11.3 (r)-6 (a)]TJ [(di)2.6 (oi)2.6 (odi)2.6 (ne.)-6.6 ( E)2 (ndoc)-2 (r)-5.9 ( R)2.6 (el)2.6 (at)4.3 ( C)2.6 (a)10.5 (nc)-2 (er)-6 ( 2010)10.5 (;)-6.6 (17:)-6.6 (R)2.6 (161)]TJ 0 Tc 0 Tw 30.304 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(172.)4.2 ( )]TJ 0.007 Tw -30.641 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (20448022)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 378 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 375.96 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 354.36 Tm [(269.)-6.7 ( H)2.7 (ay)8.9 ( I)-6.6 (D)2.6 (,)4.2 ( )11.3 (G)-6.6 (onz)8.9 (al)2.6 (ez)]TJ 0 Tc 0 Tw 10.011 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(L)-11.2 (os)-2 (ada )11.3 (T)-10.6 (,)4.3 ( R)2.6 (ei)2.6 (nal)2.7 (da M)15.8 (S)2 (,)-6.6 ( et)-6.6 ( al)2.6 (.)4.3 ( Lon)10.5 (g)]TJ 0 Tc 0 Tw 15.641 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(t)-6.6 (er)4.9 (m)-6 ( o)10.5 (ut)-6.6 (c)-2 (o)10.5 (m)-6 (e )]TJ -26.315 -1.141 Td [(i)2.6 (n 215 c)-2 (hi)2.6 (l)2.6 (dr)-5.9 (en an)]TJ [(d)10.5 ( adol)13.4 (es)-2 (c)-2 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( t)-6.6 (hy)-2 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-6 ( )11.3 (t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (ed )]TJ 0 -1.141 Td [(dur)-6 (i)2.7 (ng 1940 )11.2 (t)-6.6 (hr)-6 (ou)10.5 (g)-11.2 (h)10.5 ( 200)10.5 (8.)-6.6 ( )33 (W)-36.3 (o)10.6 (r)-6 (l)2.6 (d J)8.9 ( S)2 (ur)5 (g 2010;)-6.6 (34)10.5 (:)4.2 (1192)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 24.435 0 Td [(1202.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -24.435 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (20087589)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 316.44 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 314.4 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 292.8 Tm [(270.)-6.7 ( J)-2 (a)10.6 (r)-6 (z)8.9 (ab B)1.9 (,)-6.6 ( H)2.7 (and)10.6 (k)-12.9 (i)2.6 (ew)13.4 (i)2.7 (c)-2 (z)]TJ 0 Tc 0 Tw 12.283 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(J)-2 (unak)-12.9 ( D)13.5 (,)-6.6 ( )33 (W)-36.3 (l)2.6 (oc)-2 (h)10.5 ( J)8.9 (.)-6.6 ( J)-2 (u)10.5 (v)8.9 (eni)-8.3 (l)2.6 (e di)2.6 (f)-6.6 (f)-6.6 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( )]TJ -12.62 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a )0.5 (and)10.5 ( t)-6.6 (h)10.5 (e r)-5.9 (ol)2.6 (e o)10.5 (f)-6.6 ( )11.3 (r)-6 (adi)2.6 (oi)2.6 (odi)2.6 (ne i)2.6 (n i)2.6 (t)-6.6 (s)8.9 ( t)4.3 (r)-5.9 (eat)4.2 (m)-5.9 (ent)4.2 (:)-6.6 ( a)10.5 ( )11.3 (q)-11.2 (ual)2.6 (i)2.6 (t)-6.6 (at)-6.6 (i)2.6 (v)8.9 (e )]TJ 0 -1.152 Td [(r)-6 (ev)8.9 (i)2.6 (e)-11.2 (w)13.4 (.)-6.6 ( E)2 (ndoc)-1.9 (r)-6 ( R)2.6 (el)2.6 (at)4.3 ( C)2.6 (a)10.5 (nc)-2 (er)-5.9 ( 2005)10.5 (;)-6.6 (12:)-6.6 (773)]TJ 0 Tc 0 Tw 18.5 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(803.)4.2 ( A)12.9 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -18.837 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)]TJ -0.002 Tc 0.002 Tw 7.587 0 Td [(l)2.6 (m)-5.9 (.)-6.7 (ni)2.6 (h.)4.2 (gov)8.9 (/)-6.6 (pubm)-6 (ed/)-6.6 (16322322)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 254.88 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 252.84 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 231.24 Tm [(271.)-6.7 ( H)2.7 (o A)2 (L)10.5 (,)-6.6 ( )11.2 (G)4.3 (r)-5.9 (ew)13.5 (al)2.7 ( R)2.7 (K)1.9 (,)-6.6 ( Leboeu)10.5 (f)-17.5 ( R)2.6 (,)4.3 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( S)2 (el)2.6 (um)-6 (e)10.6 (t)-6.7 (i)2.6 (ni)2.6 (b)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 24.043 0 Td [(enhanc)-2 (ed )]TJ 0.007 Tw -24.043 -1.152 Td [(r)-6 (adi)2.7 (oi)2.6 (odi)2.6 (ne upt)-6.6 (a)10.6 (k)-12.9 (e i)2.7 (n a)10.5 (dv)8.8 (anc)-2 (ed t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)8.9 (er)4.9 (.)-6.6 ( N)2.6 ( )11.3 (E)1.9 (ng)-11.3 (l)2.6 ( )0.5 (J)8.8 ( M)15.8 (ed )]TJ 0.002 Tw 0 -1.141 Td [(2013;)-6.6 (368:)-6.6 (623)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(632.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -6.435 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)]TJ -0.002 Tc 0.002 Tw 6.533 0 Td [(i)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.8 (/)-6.6 (pubm)-5.9 (ed/)-6.7 (23406027)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 193.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 191.28 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 169.68 Tm [(272.)-6.7 ( S)2 (her)4.9 (m)-5.9 (an)10.6 ( S)2 (I)4.3 (,)-6.6 ( )11.2 (T)-10.5 (i)2.6 (el)2.6 (ens)-2 ( E)12.9 (T)-10.6 (,)4.3 ( S)2 (os)-2 (t)4.2 (r)-5.9 (e S)12.9 (,)-6.7 ( e)10.6 (t)-6.7 ( )0.5 (al)2.6 (.)4.3 ( C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( ut)-6.6 (i)2.6 (l)2.6 (i)2.6 (t)-6.6 (y)8.9 ( of)-6.6 ( )]TJ 0 -1.152 Td [(pos)-2 (t)-6.6 (t)4.3 (r)-6 (eat)4.3 (m)-6 (ent)4.3 ( r)-6 (a)10.6 (di)2.6 (oi)2.6 (odi)2.6 (n)-11.2 (e s)-2 (c)-2 (ans)8.9 ( i)2.6 (n t)-6.7 (he)10.5 ( m)4.9 (ana)10.6 (g)-11.2 (em)4.9 (ent)-6.6 ( o)10.5 (f)-6.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (i)2.7 (t)-6.7 (h )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a.)4.3 ( J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.7 (nol)2.6 ( M)15.8 (et)-6.6 (ab 1994;)4.3 (78:)-6.6 (629)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 25.109 0 Td [(634)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -25.109 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8126134)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 131.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 129.6 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 108 Tm [(273.)-6.7 ( P)2 (ac)-2 (i)2.6 (ni)2.6 ( F,)4.3 ( M)15.8 (ol)2.6 (i)2.7 (nar)-5.9 (o E)2 (,)-6.6 ( C)2.6 (as)-2 (t)-6.7 (a)10.6 (g)-11.2 (na)10.5 ( M)15.8 (G)-6.6 (,)-6.6 ( e)10.5 (t)-6.6 ( al)13.4 (.)-6.6 ( R)13.5 (ec)-2 (om)-5.9 (bi)2.6 (nant)4.2 ( hum)-5.9 (an)10.5 ( )]TJ 0.002 Tw 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (ot)-6.6 (r)-5.9 (opi)2.6 (n)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 5.043 0 Td [(s)-2 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (a)10.5 (t)-6.6 (ed s)-2 (e)10.6 (r)-6 (um)5 ( t)-6.6 (hy)8.9 (r)-6 (o)10.6 (g)-11.3 (l)2.6 (obul)2.6 (i)2.6 (n c)-2 (om)-5.9 (bi)13.5 (ned w)13.4 (i)2.6 (t)-6.6 (h nec)-2 (k)-2 ( )]TJ -5.043 -1.152 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2 (ono)10.5 (g)-11.2 (r)-6 (aphy)8.8 ( has)8.9 ( t)-6.6 (he)10.5 ( )11.3 (hi)2.6 (g)-11.2 (hes)-2 (t)4.3 ( s)-2 (ens)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (i)2.6 (t)-6.6 (y)8.8 ( )]TJ [(i)2.6 (n m)-6 (on)10.5 (i)2.6 (t)-6.6 (or)-6 (i)2.6 (ng di)13.4 (f)-6.6 (f)-6.6 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.7 (ed )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a.)4.3 ( J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.7 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2003;)4.3 (88:)-6.6 (3668)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 25.663 0 Td [(3673)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e )]TJ -0.006 Tc 0.006 Tw -25.663 -1.141 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.7 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (12915653)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 267.48 57.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 38.88 55.44 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(274.)-6.7 ( P)2 (ac)-2 (i)2.6 (ni)2.6 ( F,)4.3 ( La)10.6 (r)-6 (i)2.6 ( R)2.6 (,)4.3 ( M)15.8 (a)-11.2 (z)-2 (z)8.8 (eo S)2 (,)-6.6 ( et)4.3 ( al)2.6 (.)4.3 ( D)2.6 (i)2.6 (ag)-11.2 (nos)8.9 (t)-6.7 (i)2.6 (c)-1.9 ( )11.2 (v)8.9 (al)2.6 (ue of)-17.5 ( a)10.5 ( s)-2 (i)2.6 (n)10.6 (g)-11.3 (l)2.7 (e s)-2 (e)10.5 (r)-5.9 (um)4.9 ( )]TJ 0 -1.152 Td [(t)-6.6 (hy)8.9 (r)-5.9 (og)-11.2 (l)2.6 (obul)2.6 (i)2.6 (n det)-6.6 (e)10.5 (r)-5.9 (m)-6 (i)2.7 (na)10.5 (t)-6.6 (i)2.6 (on on and)10.5 ( o)10.5 (f)-6.6 (f)-6.6 ( )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d s)-2 (up)10.5 (pr)-5.9 (es)-2 (s)-2 (i)2.6 (v)8.9 (e t)-6.6 (her)-6 (apy)8.9 ( i)2.6 (n )11.2 (t)-6.6 (he )]TJ -0.005 Tc 0.005 Tw 0 -1.141 Td [(f)-9.6 (o)-3.4 (llo)-3.3 (w)]TJ 0 Tc 0 Tw 2.533 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up of)-6.7 ( pat)-6.7 (i)2.7 (ent)4.2 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (nc)-2 (er)-6 (.)4.3 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.6 (nol)2.6 ( )]TJ -2.87 -1.152 Td [(\()-6 (O)-6.6 (x)19.8 (f)-17.5 (\))4.9 ( 1985;)-6.6 (23)10.5 (:)-6.6 (405)]TJ 0 Tc 0 Tw 8.033 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(411.)4.2 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )]TJ 0.005 Tc -0.005 Tw 6.522 0 Td [(a)6.7 (t: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw -14.891 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (4064348)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 463.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 461.28 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 439.68 Tm [(275.)-6.7 ( H)2.7 (au)10.5 (g)-11.2 (en)10.5 ( B)1.9 (R)2.7 (,)-6.7 ( P)2 (ac)-2 (i)2.6 (ni)2.6 ( )11.3 (F,)-6.6 ( R)2.6 (ei)2.6 (ner)-6 (s)8.9 ( C)2.6 (,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( A)12.8 ( c)-2 (o)10.6 (m)-6 (par)-6 (i)2.7 (s)-2 (on )11.2 (o)10.6 (f)-6.6 ( r)-6 (ec)-2 (o)10.6 (m)-6 (bi)2.6 (nant)4.3 ( )]TJ 0 -1.152 Td [(hum)-6 (an )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (ot)-6.6 (r)-5.9 (opi)2.6 (n)10.5 ( and )11.2 (t)-6.6 (h)10.6 (y)8.8 (r)-5.9 (oi)2.6 (d hor)-6 (m)-5.9 (one)10.5 ( w)13.5 (i)2.6 (t)-6.6 (hdr)-6 (aw)2.6 (al)2.7 ( )11.2 (f)-17.5 (or)4.9 ( t)-6.6 (he)10.5 ( det)-6.6 (e)10.5 (c)-2 (t)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( )]TJ 0.002 Tw 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 3.272 0 Td [(r)-6 (em)4.9 (nant)4.2 ( or)4.9 ( c)-2 (anc)-2 (e)10.5 (r)-5.9 (.)4.2 ( J)-2 ( C)2.6 (l)2.7 (i)2.5 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 1999;)-6.6 (84)10.5 (:)-6.6 (3877)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 25.88 0 Td [(3885)10.5 (.)-6.6 ( )]TJ 0.007 Tw -29.152 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (10566623)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 401.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 399.72 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 378 Tm [(276.)-6.7 ( K)2 (l)2.6 (oos)-2 ( R)13.5 (T,)-6.6 ( M)15.8 (az)-2 (z)8.9 (af)-17.4 (er)5 (r)-6 (i)2.6 ( E)2 (L.)4.3 ( A)1.9 ( s)-2 (i)2.6 (n)10.6 (g)-11.3 (l)2.6 (e r)-6 (e)10.6 (c)-2 (om)-5.9 (bi)2.6 (na)10.5 (nt)-6.7 ( )0.5 (hu)10.5 (m)-5.9 (an )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (ot)-6.6 (r)5 (opi)2.6 (n)]TJ 0 Tc 0 Tw (-)Tj -0.005 Tc 0.005 Tw 0 -1.141 Td [(s)-5 (t)-9.6 (im)-9 (u)]TJ -0.002 Tc 0.007 Tw 2.391 0 Td [(l)2.6 (at)-6.6 (ed)10.5 ( s)-2 (er)-6 (u)10.5 (m)5 ( t)-6.6 (hy)8.9 (r)-6 (o)10.5 (g)-11.2 (l)2.6 (obul)2.6 (i)2.6 (n m)-6 (eas)-2 (ur)-6 (e)10.5 (m)-5.9 (ent)4.2 ( )0.5 (pr)-6 (e)10.6 (di)2.6 (c)-2 (t)-6.6 (s)-2 ( di)13.4 (f)-6.6 (f)-6.6 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( )]TJ -2.391 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a )11.3 (m)-5.9 (et)-6.6 (as)8.8 (t)-6.6 (as)-2 (es)-2 ( )11.3 (t)-6.6 (hr)-5.9 (ee)10.5 ( )11.2 (t)-6.6 (o )11.3 (f)-17.5 (i)2.6 (v)8.8 (e y)8.9 (ear)-6 (s)-2 ( l)13.5 (at)-6.6 (er)4.9 (.)-6.6 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n )0.5 (E)1.9 (ndoc)-2 (r)-6 (i)2.6 (nol)2.6 ( )]TJ 0 -1.152 Td [(M)15.8 (et)-6.6 (ab 2005;)-6.6 (90:)-6.6 (5047)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.489 0 Td [(50)10.5 (57.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -9.489 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)6.6 (l)9.6 (m)1.1 (.n)]TJ -0.002 Tc 0.002 Tw 9.478 0 Td [(i)2.6 (h.)4.2 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (15972576)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 327.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 325.44 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 303.84 Tm [(277.)-6.7 ( Ladens)-2 (on)10.5 ( P)23.7 (W)-25.4 (,)4.3 ( B)12.9 (r)-6 (av)8.9 (er)-6 (m)-5.9 (an)10.5 ( LE)2 (,)4.2 ( M)15.8 (a)-11.2 (z)8.9 (z)8.8 (af)-17.5 (er)-6 (r)-5.9 (i)2.6 ( E)1.9 (L)10.5 (,)-6.6 ( e)10.6 (t)-6.7 ( al)2.6 (.)4.3 ( C)2.6 (om)-5.9 (pa)10.6 (r)-6 (i)2.6 (s)-2 (on o)10.5 (f)-6.6 ( )]TJ 0 -1.152 Td [(adm)-6 (i)2.7 (ni)2.6 (s)-2 (t)-6.6 (r)-5.9 (a)10.5 (t)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( r)-6 (e)10.6 (c)-2 (om)-5.9 (b)10.5 (i)2.6 (nant)-6.7 ( )0.5 (hum)-6 (an)10.6 ( t)4.2 (hy)8.9 (r)-6 (ot)-6.7 (r)-5.9 (opi)2.6 (n )11.2 (w)2.6 (i)2.6 (t)-6.6 (h w)13.5 (i)2.6 (t)-6.6 (hdr)-6 (aw)13.5 (a)-11.3 (l)2.7 ( o)10.5 (f)-17.5 ( )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.141 Td [(hor)-6 (m)-5.9 (one)10.5 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )11.3 (r)-6 (adi)2.6 (oac)-2 (t)-6.6 (i)2.6 (v)8.9 (e i)2.6 (odi)2.7 (ne s)-2 (c)-2 (anni)2.6 (ng i)2.6 (n pa)10.6 (t)-6.6 (i)2.6 (ent)4.2 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( N)13.5 ( E)2 (ng)-11.2 (l)13.4 ( J)-2 ( M)15.8 (ed )]TJ 0.002 Tw [(1997;)-6.6 (337)10.5 (:)-6.6 (888)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 17.848 0 Td [(896)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -17.848 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9302303)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 253.2 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 251.16 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 229.56 Tm [(278.)-6.7 ( M)15.8 (az)-2 (z)8.8 (af)-17.5 (er)4.9 (r)-6 (i)2.7 ( E)1.9 (L,)4.2 ( K)2 (l)2.6 (oos)-2 ( R)2.6 (T.)4.3 ( I)-6.7 (s)8.9 ( di)2.6 (ag)-11.2 (no)10.5 (s)-2 (t)-6.6 (i)2.6 (c)8.9 ( i)2.6 (odi)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 22.38 0 Td [(131 s)-2 (c)-2.1 (anni)2.6 (n)10.6 (g w)13.5 (i)2.6 (t)-6.6 (h )]TJ -22.38 -1.141 Td [(r)-6 (ec)-2 (om)-5.9 (bi)2.7 (nan)10.5 (t)-6.6 ( hu)10.5 (m)-5.9 (an )11.3 (T)-10.6 (S)2 (H)13.5 ( us)-2 (e)10.5 (f)-17.5 (ul)2.6 ( i)2.6 (n)10.5 ( t)-6.6 (he)10.5 ( )11.3 (f)-17.5 (ol)2.6 (l)2.7 (ow)]TJ 0 Tc 0 Tw 19.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up o)10.5 (f)-6.6 ( di)13.4 (f)]TJ -0.004 Tw 3.543 0 Td [(f)-17.5 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0.007 Tw -23.424 -1.152 Td [(c)-2 (anc)-2 (er)-6 ( a)10.5 (f)-6.6 (t)-6.6 (e)10.5 (r)-5.9 ( )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d abl)2.6 (at)4.3 (i)2.6 (on? J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2002)10.5 (;)-6.6 (87:)-6.6 (1490)]TJ 0 Tc 0 Tw 30.022 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(1498)10.5 (.)-6.6 ( )]TJ 0.007 Tw -30.359 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (11932270)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 191.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 189.6 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.005 Tc 0.01 Tw 11.04 -0 0 11.04 405 168 Tm [(2)-3.3 (7)-3.4 (9)-3.3 (.)-9.7 ( Ca)-3.3 (s)5.8 (t)-9.6 (a)7.5 (g)-14.2 (n)-3.3 (a)-3.4 ( M)12.8 (G)-9.7 (,)1.3 ( B)-1.1 (r)-8.9 (illi L)-3.4 (,)-9.6 ( P)-1.1 (illi T)-2.7 (,)-9.6 ( e)7.5 (t)-9.6 ( a)-3.4 (l.)]TJ 0 Tc 0 Tw 17.337 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(Li)2.6 (m)-6 (i)2.6 (t)-6.6 (ed)10.5 ( v)8.8 (al)2.6 (ue o)10.5 (f)-17.4 ( )11.2 (r)-5.9 (epeat)4.2 ( )]TJ -0.004 Tw -17.62 -1.152 Td [(r)-6 (ec)-2 (om)-5.9 (bi)2.7 (nan)10.5 (t)-6.6 ( )-10.6 (hu)10.5 (m)-5.9 (an t)-6.6 (hy)8.9 (r)-6 (ot)-6.6 (r)-6 (opi)2.6 (n \()-5.9 (r)-6 (h)10.6 (T)-10.6 (S)2 (H)2.6 (\))]TJ 0 Tc 0 Tw 17.62 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(s)-2 (t)-6.6 (i)13.5 (m)-6 (ul)2.6 (at)4.3 (ed t)-6.6 (hy)8.9 (r)-5.9 (o)10.5 (g)-11.2 (l)2.6 (obul)2.7 (i)2.6 (n t)-6.6 (es)8.9 (t)-6.6 (i)2.6 (ng i)2.6 (n )]TJ -17.957 -1.141 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (r)4.9 (c)-2 (i)2.6 (nom)-6 (a pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h pr)-5.9 (e)10.5 (v)8.9 (i)2.6 (ous)-2 ( neg)-11.2 (at)-6.6 (i)2.6 (v)8.9 (e r)-5.9 (h)10.5 (T)-10.6 (S)2 (H)]TJ 0 Tc 0 Tw 30.967 0 Td (-)Tj -0.002 Tc 0.007 Tw -30.967 -1.141 Td [(s)-2 (t)-6.6 (i)2.6 (m)-6 (ul)2.6 (at)-6.6 (ed)10.5 ( t)-6.6 (hy)8.8 (r)-5.9 (o)10.5 (g)-11.2 (l)2.6 (obul)2.6 (i)2.6 (n and undet)-6.6 (ec)8.8 (t)-6.6 (abl)2.6 (e bas)-2 (al)2.5 ( )11.3 (s)8.9 (er)-5.9 (um)5 ( t)-6.7 (hy)8.9 (r)-6 (o)10.5 (g)-11.2 (l)2.6 (obul)2.6 (i)2.6 (n )]TJ -0.005 Tc 0.01 Tw 0 -1.152 Td [(le)-3.3 (v)5.8 (e)-14.2 (ls)-5 (.)-9.6 ( J)-5 ( Clin)-3.3 ( E)-1.1 (n)-3.3 (d)]TJ -0.002 Tc 0.007 Tw 7.652 0 Td [(oc)8.8 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2008;)-6.6 (93:)-6.6 (76)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 11.587 0 Td [(81)10.5 (.)-6.6 ( A)12.8 (v)8.9 (ai)-8.2 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -19.239 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (17971424)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 104.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 102.72 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 81.12 Tm [(280.)-6.7 ( S)2 (penc)-2 (e)10.5 (r)-6 ( C)13.5 (,)-6.6 ( P)2 (et)4.3 (r)-6 (ov)8.9 (i)2.5 (c)-1.9 ( I)4.3 (,)-6.6 ( Fa)10.5 (t)-6.6 (em)-6 (i)2.6 ( S)12.9 (,)-6.7 ( LoP)12.8 (r)-6 (es)-2 (t)-6.6 (i)13.4 ( J)-2 (.)4.3 ( )11.3 (S)1.9 (er)-6 (um)4.9 ( t)-6.6 (hy)8.9 (r)-6 (o)10.6 (g)-11.2 (l)2.6 (obul)2.6 (i)2.6 (n \()4.9 (Tg)-11.2 (\))4.9 ( )]TJ 0 -1.152 Td [(m)-6 (oni)2.7 (t)-6.6 (or)-5.9 (i)2.6 (n)10.5 (g o)10.6 (f)-6.6 ( pat)-6.6 (i)2.5 (ent)4.2 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h )0.5 (di)13.5 (f)-6.6 (f)-17.5 (e)]TJ 13.739 0 Td [(r)-6 (ent)-6.6 (i)2.7 (at)-6.6 (e)10.5 (d )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (d c)8.9 (anc)-2 (er)-5.9 ( us)-2 (i)2.6 (n)10.6 (g s)-2 (ens)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (e )]TJ 0.002 Tw -13.739 -1.141 Td [(\()-6 (s)-2 (ec)-2 (ond)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 3.88 0 Td [(g)-11.2 (ene)10.5 (r)-5.9 (at)-6.6 (i)2.6 (on)10.5 (\))-6 ( i)2.6 (m)5 (m)4.9 (unom)-5.9 (et)4.3 (r)-6 (i)2.6 (c)-2 ( as)-2 (s)-2 (ay)8.8 (s)-2 ( c)-2 (an)10.5 ( be)10.6 ( di)2.6 (s)-2 (r)-5.9 (upt)-6.6 (ed)10.5 ( by)8.9 ( )11.2 (f)-17.5 (al)2.6 (s)-2 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw -3.88 -1.152 Td [(neg)-11.2 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e )-10.6 (and f)-17.5 (al)2.6 (s)-2 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 8.435 0 Td [(po)10.5 (s)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (e s)-2 (er)-6 (um)4.9 ( t)-6.6 (hy)8.9 (r)-6 (o)10.6 (g)-11.3 (l)2.7 (obul)2.6 (i)2.6 (n aut)-6.6 (oant)-6.6 (i)2.6 (body)8.9 ( )]TJ EMC ET endstream endobj 1024 0 obj 28912 endobj %% Contents for page 119 %% Original object ID: 239 0 1025 0 obj << /Length 1026 0 R >> stream Q q BT /Xi117 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1026 0 obj 246 endobj %% Original object ID: 11754 0 1027 0 obj [ 2927 0 R 2928 0 R 2929 0 R 2930 0 R 2931 0 R 2932 0 R 2933 0 R 2934 0 R 2935 0 R 2936 0 R 2937 0 R 2938 0 R 2939 0 R 2940 0 R 2941 0 R ] endobj %% Contents for page 120 %% Original object ID: 240 0 1028 0 obj << /Length 1029 0 R >> stream q endstream endobj 1029 0 obj 2 endobj %% Contents for page 120 %% Original object ID: 11755 0 1030 0 obj << /Length 1031 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (57)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(m)-6 (i)2.7 (s)-2 (c)-2.1 (l)2.7 (as)-2 (s)-2 (i)13.5 (f)-17.5 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (ons)-2 (.)4.3 ( J)8.8 ( C)2.6 (l)2.6 (i)2.7 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2014;)-6.6 (9)10.6 (9:)-6.6 (4589)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 25.489 0 Td [(4599)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e )]TJ -0.006 Tc 0.006 Tw -25.489 -1.152 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (25226290)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 267.48 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 38.88 499.2 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 477.6 Tm [(281.)-6.7 ( S)2 (penc)-2 (e)10.5 (r)-6 ( C)13.5 (,)-6.6 ( LoP)2 (r)-6 (e)10.5 (s)-2 (t)4.3 (i)2.6 ( J)-2 (,)-6.6 ( Fa)10.5 (t)-6.6 (e)10.5 (m)-5.9 (i)2.6 ( S)1.9 (.)4.3 ( H)2.6 (ow)13.4 ( s)-2 (ens)-2 (i)2.7 (t)-6.7 (i)2.7 (v)8.8 (e \()-6 (s)-2 (ec)-2 (ond)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 27.304 0 Td [(g)-11.2 (ener)-5.9 (a)10.5 (t)-6.6 (i)2.6 (on\))-5.9 ( )]TJ 0.007 Tw -27.304 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (og)-11.2 (l)2.6 (obul)2.6 (i)2.6 (n m)-5.9 (ea)10.5 (s)-1.9 (ur)-5.9 (e)10.5 (m)4.9 (ent)-6.6 ( i)2.6 (s)-2 ( )11.3 (c)-2 (han)10.5 (g)-11.2 (i)2.6 (ng par)-6 (adi)13.5 (gm)-6 (s)-2 ( )11.3 (f)-6.6 (or)4.9 ( )11.3 (m)-5.9 (oni)2.6 (t)-6.6 (or)-5.9 (i)2.6 (n)10.5 (g)-11.2 ( pa)10.6 (t)-6.7 (i)2.7 (ent)4.2 (s)-2 ( )]TJ 0 -1.152 Td [(w)2.6 (i)2.6 (t)-6.6 (h di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (at)-6.6 (e)]TJ [(d)10.5 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (,)-6.6 ( i)2.6 (n)10.6 ( t)-6.6 (he)10.5 ( abs)-2 (enc)-2 (e)10.5 ( )11.3 (or)-6 ( p)10.5 (r)-5.9 (es)-2 (enc)-2 (e o)10.5 (f)-6.6 ( )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (og)-11.2 (l)2.6 (obul)2.6 (i)2.6 (n aut)-6.6 (oan)10.6 (t)-6.6 (i)2.6 (bo)10.5 (di)2.6 (es)-2 (.)-6.6 ( C)2.7 (ur)4.9 (r)-5.9 ( )11.2 (O)-6.6 (pi)2.6 (n E)2 (ndoc)8.9 (r)-5.9 (i)2.6 (nol)2.6 ( D)2.6 (i)2.6 (abet)-6.6 (es)-2 ( )11.3 (O)-6.6 (bes)-2 ( )]TJ 0.002 Tw 0 -1.152 Td [(2014;)-6.6 (21:)-6.6 (394)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(404.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (25122493)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 412.32 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 390.72 Tm [(282.)-6.7 ( S)2 (p)]TJ [(enc)-2 (e)10.5 (r)-6 ( C)2.6 (A)2 (,)4.3 ( )11.2 (T)-10.5 (a)10.5 (k)-12.9 (eu)10.5 (c)-2 (hi)2.6 ( M)15.8 (,)-6.6 ( K)2 (az)8.9 (ar)-6 (os)-2 (y)8.8 (an )-10.4 (M)15.8 (.)-6.7 ( C)2.6 (ur)-6 (r)-5.9 (en)10.6 (t)-6.6 ( s)8.8 (t)-6.6 (at)-6.6 (us)8.9 ( and)10.5 ( )]TJ 0 -1.152 Td [(per)4.9 (f)-17.5 (o)10.6 (r)-6 (m)-5.9 (anc)-2 (e)10.5 ( )11.2 (g)-11.2 (oal)2.7 (s)-2.1 ( )11.3 (f)-6.6 (or)4.9 ( s)-2 (e)10.5 (r)-6 (um)4.9 ( t)-6.6 (hy)8.9 (r)-5.9 (o)10.5 (g)-11.2 (l)2.6 (obul)2.7 (i)2.6 (n as)-2 (s)-2 (ay)8.9 (s)-2 (.)-6.6 ( C)2.6 (l)2.6 (i)2.6 (n C)2.6 (hem)4.9 ( )]TJ 0.002 Tw 0 -1.141 Td [(1996;)-6.6 (42:)-6.6 (164)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(173.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.7 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8565221)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 350.76 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 329.16 Tm [(283.)-6.7 ( S)2 (penc)-2 (e)10.5 (r)-6 ( C)2.6 (A)2 (,)4.3 ( Lopr)-5.9 (e)10.5 (s)-2 (t)-6.6 (i)2.6 ( J)-2 (S)2 (.)4.2 ( M)15.8 (eas)-2 (ur)-5.9 (i)2.6 (ng)-11.3 ( )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (o)10.5 (g)-11.2 (l)2.6 (obul)2.6 (i)2.7 (n and t)-6.6 (hy)8.9 (r)-6 (o)10.5 (g)-11.2 (l)2.6 (obul)2.6 (i)2.6 (n )]TJ 0 -1.152 Td [(aut)-6.6 (oant)-6.7 (i)2.7 (body)8.9 ( i)2.6 (n pat)-6.7 (i)2.7 (ent)4.2 (s)-2 ( )11.3 (w)2.6 (i)2.6 (t)-6.6 (h di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (.)-6.6 ( N)2.6 (a)10.5 (t)-6.6 ( C)2.6 (l)2.6 (i)2.6 (n P)2 (r)-6 (ac)8.9 (t)-6.6 ( )]TJ 0 -1.141 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2008;)-6.6 (4)10.5 (:)-6.6 (223)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.359 0 Td [(233)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0 Tc 0 Tw -13.359 -1.152 Td (h)Tj -0.002 Tc 0.002 Tw 0.554 0 Td [(t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.3 (/)-6.6 (w)2.6 (w)2.6 (w)13.4 (.)-6.5 (nc)-2 (bi)2.7 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.2 (gov)8.9 (/)-6.6 (pubm)-6 (ed/)-6.6 (18268520)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 291.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 289.08 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 267.48 Tm [(284.)-6.7 ( S)2 (penc)-2 (e)10.5 (r)-6 ( C)2.6 (A)2 (,)4.3 ( )11.2 (T)-10.5 (a)10.5 (k)-12.9 (eu)10.5 (c)-2 (hi)2.6 ( M)15.8 (,)-6.6 ( K)2 (az)8.9 (ar)-6 (os)-2 (y)8.8 (an )-10.4 (M)15.8 (,)-6.7 ( et)-6.6 ( )11.3 (al)2.6 (.)-6.6 ( S)2 (er)-6 (u)10.6 (m)-6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (og)-11.2 (l)2.6 (obul)2.7 (i)2.6 (n )]TJ 0 -1.141 Td [(aut)-6.6 (oant)-6.7 (i)2.7 (bodi)2.6 (es)-2 (:)4.2 ( pr)-6 (ev)8.9 (al)2.6 (enc)-2 (e,)-6.6 ( i)2.6 (n)10.5 (f)-17.5 (l)2.6 (uenc)-2 (e)10.5 ( on )11.3 (s)-2 (er)-5.9 (u)10.5 (m)-5.9 ( )11.2 (t)4.3 (hy)8.9 (r)-5.9 (og)-11.2 (l)2.6 (obul)2.6 (i)2.6 (n )]TJ 0 -1.152 Td [(m)-6 (eas)-1.9 (ur)-5.9 (e)10.5 (m)-6 (en)10.5 (t)-6.6 (,)4.2 ( and p)10.5 (r)-5.9 (o)10.5 (gnos)-2.1 (t)-6.6 (i)2.7 (c)-2 ( s)-2 (i)13.5 (g)-11.2 (ni)13.5 (f)-17.5 (i)2.6 (c)-2 (anc)-2 (e)10.5 ( i)2.6 (n pat)-6.6 (i)13.4 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (en)10.6 (t)-6.6 (i)2.6 (at)-6.6 (ed )]TJ 0.002 Tw 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ 0.007 Tw 3.272 0 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)4.9 (a.)4.2 ( J)-1.9 ( C)2.7 (l)2.6 (i)2.6 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 1998;)4.3 (83:)-6.6 (1121)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 22.391 0 Td [(1127)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e )]TJ -0.006 Tc 0.006 Tw -25.663 -1.141 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.7 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (9543128)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 261.48 216.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 38.88 214.92 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 193.32 Tm [(285.)-6.7 ( C)2.7 (hun)10.5 (g)-11.2 ( )11.2 (J)-2 (K)2 (,)4.2 ( )0.5 (P)1.9 (ar)4.9 (k)-2 ( Y)1.9 (J)-2 (,)4.3 ( K)1.9 (i)2.7 (m)-6 ( )11.3 (T)-10.6 (Y)12.8 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( s)-2 (i)2.6 (g)-11.2 (ni)13.5 (f)-17.4 (i)2.6 (c)-2 (anc)-2 (e)10.5 ( o)10.5 (f)-6.6 ( el)2.6 (ev)8.9 (at)-6.6 (ed )]TJ -0.013 Tc 0.018 Tw 0 -1.152 Td [(l)-8.4 (e)-11.3 (v)-2.2 (e)-22.2 (l)-8.4 ( of)-28.4 ( s)-13 (er)]TJ -0.002 Tc 0.007 Tw 4.826 0 Td [(um)4.9 ( ant)-6.6 (i)13.4 (t)-6.6 (hy)8.9 (r)-6 (og)-11.3 (l)13.5 (obul)2.6 (i)2.6 (n ant)-6.6 (i)2.6 (body)8.9 ( i)2.6 (n pat)-6.7 (i)2.7 (ent)4.2 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h )0.5 (di)2.6 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.6 (t)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( )]TJ -4.826 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 ( a)10.6 (f)-6.6 (t)-6.6 (er)4.9 ( t)-6.6 (hy)8.8 (r)-5.9 (o)10.5 (i)2.6 (d abl)2.6 (at)-6.6 (i)2.6 (on.)-6.6 ( C)2.6 (l)2.6 (i)2.7 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (n)10.5 (ol)2.6 ( \()-6 (O)-6.6 (x)19.7 (f)-6.6 (\))-5.9 ( 2002)10.6 (;)-6.7 (57:)-6.5 (215)]TJ 0 Tc 0 Tw 31.13 0 Td (-)Tj -0.002 Tc 0.007 Tw -31.13 -1.152 Td [(221.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.2 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)-6.6 (g)-11.2 (ov)8.9 (/)-6.6 (pu)10.5 (bm)-5.9 (ed/)-6.6 (1215360)]TJ 0 Tc 0 Tw (0)Tj EMC ET /Span <>BDC BT /CS1 cs 0 scn 11.04 -0 0 11.04 339.72 155.28 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 111.12 153.24 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 131.64 Tm [(286.)-6.7 ( C)2.7 (hi)2.6 (ov)8.8 (at)-6.6 (o L,)4.3 ( Lat)4.2 (r)-5.9 (o)10.5 (f)-17.5 (a)10.5 ( )11.3 (F,)-6.6 ( B)2 (r)-6 (av)8.8 (er)4.9 (m)-6 (an LE)12.8 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( )11.3 (D)2.6 (i)2.6 (s)-2 (appear)-6 (anc)-2 (e o)10.5 (f)-6.6 ( )]TJ 0 -1.141 Td [(hum)-6 (or)-5.9 (al)2.6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )0.5 (aut)-6.7 (oi)13.5 (m)-6 (m)4.9 (uni)2.7 (t)-6.7 (y)8.9 ( af)-6.6 (t)-6.6 (er)4.9 ( c)-2 (o)10.6 (m)-6 (pl)2.7 (et)-6.6 (e)10.5 ( r)-5.9 (e)10.5 (m)4.9 (ov)8.9 (al)2.6 ( of)-17.4 ( )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d ant)-6.6 (i)13.5 (g)-11.3 (ens)8.8 (.)-6.6 ( )]TJ 0 -1.152 Td [(A)2 (nn I)-6.7 (nt)4.3 (er)-5.9 (n)10.5 ( M)15.8 (ed 2003;)-6.6 (139:)-6.6 (346)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.533 0 Td [(351)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -13.533 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/)]TJ -0.002 Tc 0.002 Tw [(w)2.7 (w)2.6 (w)13.4 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.2 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (12965943)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 93.72 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 91.68 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 70.08 Tm [(287.)-6.7 ( P)2 (han)10.5 ( H)2.6 (T,)-6.7 ( )11.3 (J)-2 (a)10.5 (g)-11.2 (er)4.9 ( P)1.9 (L,)4.3 ( v)8.9 (an der)-5.9 ( )33 (W)-36.3 (al)13.4 ( J)-2 (E)2 (,)4.3 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( )11.3 (The )11.2 (f)-17.4 (ol)2.6 (l)2.6 (ow)]TJ 0 Tc 0 Tw 25.522 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(up o)10.5 (f)-17.5 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( )]TJ -25.859 -1.141 Td [(w)2.6 (i)2.6 (t)-6.6 (h di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 ( and u)10.5 (ndet)-6.7 (ec)8.9 (t)-6.6 (abl)2.6 (e t)-6.6 (hy)8.8 (r)-5.9 (o)10.5 (g)-11.2 (l)2.6 (obul)2.6 (i)2.6 (n \()5 (Tg)-11.3 (\))5 ( and )]TJ 34.554 41.348 Td [(Tg ant)-6.7 (i)2.7 (bodi)2.6 (es)-2 ( du)10.6 (r)-6 (i)2.6 (ng abl)2.6 (at)-6.6 (i)2.6 (on.)-6.6 ( E)1.9 (u)10.6 (r)-6 ( J)8.9 ( E)1.9 (ndoc)-2 (r)-6 (i)2.6 (nol)2.7 ( 2)10.5 (008;)-6.6 (158:)-6.6 (77)]TJ 0 Tc 0 Tw 26.489 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(83.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (a)]TJ -0.005 Tc 0.005 Tw [(b)-3.3 (le)-14.2 ( )]TJ -0.006 Tc 0.006 Tw -26.826 -1.152 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (18166820)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 648.96 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 420.36 499.2 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 477.6 Tm [(288.)-6.7 ( S)2 (c)-2 (hl)2.6 (um)-5.9 (be)10.6 (r)4.9 (g)-11.3 (er)4.9 ( M)15.8 (,)-6.6 ( M)4.9 (anc)-2 (us)-2 (i)2.7 ( F,)4.2 ( B)2 (audi)2.7 (n E)2 (,)4.2 ( P)2 (ac)-2 (i)2.6 (ni)2.6 ( F.)-6.6 ( 131)10.5 (I)-6.6 ( )11.3 (t)-6.6 (her)-6 (apy)8.9 ( )11.3 (f)-6.6 (or)4.9 ( )]TJ 0 -1.141 Td [(el)2.6 (ev)8.9 (at)-6.6 (ed t)-6.6 (hy)8.8 (r)-5.9 (og)-11.2 (l)2.6 (obul)2.6 (i)2.6 (n l)2.6 (ev)8.9 (el)2.6 (s)-2 (.)-6.6 ( T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d 1997;)-6.6 (7)10.5 (:)-6.6 (273)]TJ 0 Tc 0 Tw 21.663 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(276.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9133699)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 452.28 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 450.24 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 428.64 Tm [(289.)-6.7 ( S)2 (c)-2 (hl)2.6 (um)-5.9 (be)10.6 (r)4.9 (g)-11.3 (er)4.9 ( M)15.8 (,)-6.6 ( )11.2 (Tubi)2.6 (ana M)15.8 (,)-6.6 ( D)2.6 (e V)1.9 (at)-6.6 (hai)2.6 (r)-6 (e F)11.2 (,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( Lon)10.5 (g)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 27.033 0 Td [(t)-6.6 (e)10.5 (r)-5.9 (m)4.9 ( r)-5.9 (es)-2 (ul)2.6 (t)-6.6 (s)8.9 ( )]TJ 0.007 Tw -27.033 -1.141 Td [(o)10.5 (f)-17.5 ( )11.3 (t)-6.6 (r)-5.9 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( 283)10.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-1.9 ( w)13.5 (i)2.6 (t)-6.6 (h l)2.6 (ung and)10.6 ( bone )11.2 (m)5 (et)-6.6 (as)-2 (t)-6.6 (as)-2 (e)10.5 (s)-2 ( )11.3 (f)-6.6 (r)-6 (o)10.5 (m)-5.9 ( )]TJ -0.004 Tw 0 -1.152 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (d)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 9.315 0 Td [(c)-2 (a)10.5 (r)4.9 (c)-2 (i)2.7 (nom)-6 (a.)4.2 ( J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-5.9 (i)2.6 (no)10.5 (l)2.7 ( M)15.7 (et)-6.6 (ab 1986;)-6.6 (63:)-6.6 (960)]TJ 0 Tc 0 Tw 21.478 0 Td (-)Tj -0.002 Tc 0.007 Tw -30.793 -1.141 Td [(967.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.2 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.7 (h.)-6.6 (g)-11.2 (ov)8.9 (/)-6.6 (pu)10.5 (bm)-5.9 (ed/)-6.6 (3745409)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 715.08 390.72 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 492.6 388.68 222.48 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 367.08 Tm [(290.)-6.7 ( P)2 (i)2.6 (neda J)-2 (D)13.5 (,)-6.6 ( Lee)10.5 ( )11.3 (T)-10.6 (,)4.3 ( )11.3 (A)1.9 (i)2.6 (n K)1.9 (,)-6.6 ( et)4.2 ( al)2.6 (.)4.3 ( I)-6.6 (odi)2.7 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 18.902 0 Td [(131)10.5 ( t)4.2 (her)-6 (apy)8.9 ( f)-17.4 (or)4.9 ( )-10.6 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d )-10.6 (c)-2 (an)10.5 (c)-2 (er)5 ( )]TJ 0.007 Tw -18.902 -1.152 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)]TJ 4.707 0 Td [(t)-6.6 (h el)2.6 (ev)8.8 (at)-6.6 (ed t)-6.6 (h)10.5 (y)8.9 (r)-6 (og)-11.2 (l)2.6 (obul)2.6 (i)2.6 (n and ne)10.5 (g)-11.2 (at)-6.7 (i)2.6 (v)8.9 (e )11.2 (di)2.6 (ag)-11.3 (nos)-2 (t)-6.6 (i)2.6 (c)8.9 ( s)-2 (c)-2 (an)10.5 (.)-6.6 ( J)8.9 ( C)2.7 (l)2.6 (i)2.6 (n )]TJ -4.707 -1.141 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 1995;)-6.6 (8)10.6 (0:)-6.6 (1488)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.467 0 Td [(1492)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.467 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (7744991)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 329.16 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 327.12 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 305.52 Tm [(291.)-6.7 ( B)2 (i)2.6 (ondi)2.6 ( B)1.9 (,)4.3 ( C)2.6 (ooper)4.9 ( D)2.6 (S)2 (.)-6.6 ( B)2 (ene)10.5 (f)-17.5 (i)13.5 (t)-6.6 (s)-2 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.7 (h)]TJ [(y)8.9 (r)-6 (ot)-6.7 (r)-5.9 (o)10.5 (pi)2.6 (n s)-2 (uppr)-6 (es)8.9 (s)-2 (i)2.6 (on v)8.8 (er)-5.9 (s)-2.1 (us)-2 ( )11.3 (t)-6.7 (he )]TJ 0 -1.152 Td [(r)-6 (i)2.7 (s)-2 (k)-2 (s)-2 ( o)10.5 (f)-6.6 ( adv)8.8 (er)-6 (s)-2 (e)10.6 ( e)10.5 (f)-6.6 (f)-6.6 (ec)-2 (t)4.3 (s)-2 ( i)13.5 (n di)13.4 (f)-6.6 (f)-17.5 (e)10.6 (r)-6 (ent)-6.6 (i)2.6 (at)-6.6 (e)10.5 (d )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)8.9 (anc)-2 (er)-5.9 (.)4.2 ( )11.3 (T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0.002 Tw 0 -1.141 Td [(2010;)-6.6 (20:)-6.6 (135)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(146.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (20151821)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 267.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 265.44 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 243.84 Tm [(292.)-6.7 ( M)15.8 (c)-2 (G)-6.6 (r)-5.9 (i)13.4 (f)-6.5 (f)-6.7 ( N)2.6 (J)8.9 (,)-6.6 ( C)2.6 (s)-2 (a)10.5 (k)-12.8 (o)10.5 ( )11.2 (G)-6.6 (,)4.3 ( G)-6.6 (ou)10.5 (r)4.9 (g)-11.2 (i)2.6 (ot)-6.6 (i)2.6 (s)-2 ( L)10.6 (,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( E)12.8 (f)-6.6 (f)4.3 (ec)-2 (t)-6.6 (s)-2 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d hor)4.9 (m)-6 (one)10.5 ( )]TJ 0 -1.141 Td [(s)-2 (uppr)-6 (es)-2 (s)-2 (i)2.6 (on )11.3 (t)-6.7 (her)-5.9 (apy)8.9 ( on)10.5 ( )11.3 (adv)8.9 (er)-5.9 (s)-2 (e c)-2 (l)2.6 (i)2.7 (ni)2.6 (c)-2 (al)2.6 ( out)-6.6 (c)-2 (om)-5.9 (e)10.5 (s)-2 ( i)2.6 (n t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (an)10.5 (c)-2 (er)5 (.)-6.6 ( A)1.9 (nn)10.5 ( )]TJ 0 -1.152 Td [(M)15.8 (ed 2002;)-6.6 (34:)-6.6 (554)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 8.098 0 Td [(564.)4.2 ( A)12.9 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -8.098 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)]TJ -0.002 Tc 0.002 Tw 6.75 0 Td [(.)-6.6 (nl)2.7 (m)-6 (.)-6.6 (ni)2.7 (h.)4.3 (gov)8.8 (/)-6.6 (pubm)-6 (ed/)-6.6 (12553495)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 205.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 203.88 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 182.28 Tm [(293.)-6.7 ( K)2 (l)2.6 (ei)2.6 (n H)2.6 (es)-2 (s)-2 (el)2.7 (i)2.6 (nk)-2 ( E)2 (N)2.6 (,)4.3 ( K)2 (l)2.6 (ei)2.6 (n H)2.6 (es)-2 (s)-2 (el)2.7 (i)2.6 (nk)-12.9 ( M)15.8 (S)2 (,)-6.6 ( de )11.2 (B)2 (oc)-2 (k)-2 ( G)-6.6 (H)13.5 (,)-6.6 ( e)10.5 (t)-6.6 ( al)13.5 (.)-6.7 ( )0.5 (Lon)10.6 (g)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 0 -1.141 Td [(t)-6.6 (er)5 (m)-6 ( c)-2 (a)10.5 (r)-5.9 (di)2.6 (ov)8.9 (as)-2 (c)-2 (ul)2.6 (ar)-5.9 ( m)-6 (o)10.5 (r)-5.9 (t)4.2 (al)2.6 (i)2.6 (t)-6.6 (y)8.9 ( i)2.6 (n pat)-6.6 (i)2.7 (ent)-6.7 (s)-2 ( )0.5 (w)13.4 (i)2.6 (t)-6.6 (h di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (:)-6.6 ( an)10.6 ( obs)-1.9 (er)-6 (v)8.9 (at)-6.6 (i)13.4 (onal)2.6 ( s)-2 (t)-6.6 (udy)8.9 (.)-6.6 ( J)8.8 ( C)2.6 (l)2.6 (i)2.7 (n O)-6.6 (nc)-2 (ol)13.5 ( )11.3 (2013;)-6.6 (31:)-6.6 (4046)]TJ 0 Tc 0 Tw 27.413 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(4053.)4.3 ( )]TJ 0.007 Tw -27.75 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (24101052)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 144.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 142.32 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 120.72 Tm [(294.)-6.7 ( R)2.7 (ev)8.9 (er)-5.9 (t)-6.6 (e)10.5 (r)-6 ( J)-2 (L)10.6 (,)-6.7 ( H)2.7 (ol)13.5 (g)-11.2 (ad)10.6 (o S)1.9 (,)-6.6 ( A)2 (l)2.6 (ons)-2 (o)10.6 ( N)2.6 (,)4.3 ( et)4.2 ( al)2.6 (.)-6.6 ( La)10.5 (c)8.9 (k)-2 ( o)10.5 (f)-6.6 ( del)2.6 (et)-6.6 (er)-5.9 (i)2.6 (ous)8.9 ( e)10.5 (f)-6.6 (f)-6.6 (ec)8.9 (t)-6.6 ( on)10.6 ( )]TJ 0 -1.152 Td [(bone m)-5.9 (i)2.6 (ner)-6 (al)13.5 ( dens)-2 (i)2.6 (t)-6.6 (y)8.9 ( o)10.5 (f)-6.6 ( l)2.6 (ong)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 12.804 0 Td [(t)-6.6 (e)10.5 (r)-5.9 (m)4.9 ( t)-6.6 (hy)8.9 (r)-6 (ox)8.9 (i)2.6 (ne s)-2 (uppr)4.9 (es)-2 (s)-2 (i)2.6 (v)8.9 (e t)-6.6 (her)-5.9 (apy)8.9 ( )11.2 (f)-17.5 (or)4.9 ( )]TJ 0.002 Tw -12.804 -1.141 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (e)]TJ 0.007 Tw [(d )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (r)4.9 (c)-2 (i)2.6 (nom)-6 (a.)4.2 ( E)2 (ndoc)-2 (r)5 ( R)2.6 (el)2.6 (at)-6.6 ( C)2.6 (a)10.5 (nc)-1.9 (er)-5.9 ( 2005)10.5 (;)-6.6 (12:)-6.6 (973)]TJ 0 Tc 0 Tw 29.522 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(981.)4.2 ( )]TJ 0.007 Tw -29.859 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (16322336)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 82.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 80.64 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 59.04 Tm [(295.)-6.7 ( )11.3 (Q)-6.6 (uan M)15.8 (L,)-6.6 ( P)1.9 (as)-2 (i)2.6 (e)10.5 (k)-12.8 (a )11.3 (J)-2 (L,)-6.6 ( R)2.6 (o)10.6 (r)-6 (s)-2 (t)-6.6 (ad)10.5 ( O)4.2 (.)4.3 ( B)2 (one )11.3 (m)-6 (i)2.6 (ner)-5.9 (al)2.6 ( dens)-2 (i)2.6 (t)-6.6 (y)8.9 ( i)2.6 (n w)13.5 (el)2.6 (l)]TJ 0 Tc 0 Tw 29.739 0 Td (-)Tj -0.002 Tc 0.002 Tw -29.739 -1.141 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (e)]TJ 0.007 Tw [(d )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (an)10.5 (c)-2 (er)-6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( t)4.3 (r)-6 (eat)-6.6 (ed)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h s)-2 (uppr)-6 (es)-2 (s)-2 (i)2.6 (v)8.9 (e t)-6.6 (hy)8.8 (r)-5.9 (ox)8.9 (i)2.6 (ne:)-6.6 ( a )]TJ EMC ET endstream endobj 1031 0 obj 27753 endobj %% Contents for page 120 %% Original object ID: 241 0 1032 0 obj << /Length 1033 0 R >> stream Q q BT /Xi118 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1033 0 obj 246 endobj %% Original object ID: 11772 0 1034 0 obj [ 2942 0 R 2943 0 R 2944 0 R 2945 0 R 2946 0 R 2947 0 R 2948 0 R 2949 0 R 2950 0 R 2951 0 R 2952 0 R 2953 0 R 2954 0 R 2955 0 R 2956 0 R ] endobj %% Contents for page 121 %% Original object ID: 242 0 1035 0 obj << /Length 1036 0 R >> stream q endstream endobj 1036 0 obj 2 endobj %% Contents for page 121 %% Original object ID: 11773 0 1037 0 obj << /Length 1038 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (58)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(s)-2 (y)8.9 (s)-2 (t)-6.6 (em)-5.9 (at)-6.6 (i)2.6 (c)8.9 ( ov)8.9 (er)-6 (v)8.9 (i)2.6 (e)-11.2 (w)13.5 ( of)-17.5 ( )11.3 (t)4.2 (he l)2.7 (i)2.6 (t)-6.6 (er)-5.9 (at)-6.6 (u)10.5 (r)-5.9 (e.)4.3 ( J)8.9 ( S)1.9 (ur)4.9 (g O)-6.6 (nc)8.8 (ol)2.6 ( 2002;)-6.6 (79:)-6.6 (62)]TJ 0 Tc 0 Tw 27.424 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(69;)4.3 ( )]TJ 0.007 Tw -27.761 -1.152 Td [(di)2.6 (s)-2 (c)-2 (us)-2 (s)-2 (i)2.6 (on 69)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 6.38 0 Td [(70)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.38 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (e)]TJ [(d/)-6.6 (11754378)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 488.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 486.6 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 465 Tm [(296.)-6.7 ( P)2 (u)10.5 (j)-8.2 (ol)2.6 ( P)2 (,)4.2 ( D)2.7 (aur)-6 (es)8.8 ( J)-2 (P)2 (,)4.2 ( )0.5 (N)2.5 (s)-2 (a)10.6 (k)-12.9 (al)2.6 (a N)2.6 (,)4.3 ( et)4.3 ( al)2.7 (.)4.2 ( D)2.6 (egr)-5.9 (e)10.5 (e o)10.6 (f)-6.6 ( t)-6.6 (hy)8.9 (r)-6 (ot)4.2 (r)-5.9 (opi)2.6 (n )]TJ 0 -1.152 Td [(s)-2 (uppr)-6 (es)-2 (s)-2 (i)2.6 (on as)8.9 ( a p)10.6 (r)-6 (o)10.5 (g)-11.2 (no)10.5 (s)-2 (t)-6.6 (i)2.6 (c)-2 ( de)10.5 (t)-6.6 (er)4.9 (m)-5.9 (i)2.6 (nant)-6.6 ( i)2.6 (n)10.6 ( di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)5 (ent)-6.7 (i)2.7 (at)-6.6 (ed )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-6 (.)4.3 ( )11.2 (J)-1.9 ( )]TJ 0 -1.141 Td [(C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.7 (nol)2.6 ( M)15.8 (et)-6.6 (ab 1996;)-6.6 (81:)-6.6 (4318)]TJ 0 Tc 0 Tw 16.12 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(4323.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -16.457 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8954034)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 426.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 424.92 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 403.32 Tm [(297.)-6.7 ( C)2.7 (ooper)4.9 ( D)2.6 (S)1.9 (,)4.3 ( S)2 (pec)8.8 (k)-12.8 (e)10.5 (r)-6 ( B)2 (,)4.2 ( H)2.7 (o M)15.8 (,)-6.6 ( et)4.3 ( al)2.7 (.)4.2 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (ot)-6.6 (r)-5.9 (o)10.5 (pi)2.6 (n s)-2 (uppr)-6 (es)-2 (s)-2 (i)2.6 (on and)10.5 ( )]TJ 0 -1.141 Td [(di)2.6 (s)-2 (eas)-2 (e pr)-6 (o)10.6 (gr)-6 (es)-2 (s)-2 (i)2.6 (on i)2.6 (n p)10.5 (at)-6.6 (i)2.6 (ent)-6.7 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h di)13.5 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.6 (t)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-6 (:)4.3 ( r)-6 (es)-2 (ul)13.5 (t)-6.6 (s)-2 ( )]TJ 0 -1.152 Td [(f)-6.6 (r)-6 (o)10.6 (m)-6 ( )11.3 (t)-6.6 (he N)2.6 (a)10.5 (t)-6.6 (i)2.6 (onal)2.6 ( T)-10.6 (hy)8.9 (r)-5.9 (oi)13.5 (d C)2.7 (anc)-2 (er)4.9 ( )11.3 (T)-10.6 (r)-5.9 (ea)10.6 (t)-6.6 (m)-6 (en)10.6 (t)-6.6 ( C)2.6 (oo)10.5 (per)-6 (at)-6.7 (i)2.7 (v)8.8 (e R)2.6 (e)]TJ -0.011 Tc 0.011 Tw [(g)-20.2 (i)-6.4 (st)-15.6 (r)-15 (y.)-15.6 ( )]TJ -0.002 Tc 0.007 Tw 0 -1.141 Td [(T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d 1998;)-6.6 (8)10.6 (:)-6.7 (737)]TJ 0 Tc 0 Tw 8.587 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(744.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (ab)-11.3 (l)2.7 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -8.924 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9777742)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 350.76 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 329.16 Tm [(298.)-6.7 ( B)2 (ur)4.9 (m)-6 (ei)2.6 (s)-2 (t)-6.6 (e)10.5 (r)-6 ( LA)12.8 (,)-6.6 ( )11.3 (G)-6.6 (ou)10.6 (m)-6 (az)8.9 ( M)15.8 (O)-6.6 (,)-6.6 ( M)15.8 (ar)-5.9 (i)2.6 (as)-2 (h C)2.6 (N)2.6 (,)-6.6 ( )11.2 (O)4.3 (ppenhei)2.6 (m)-5.9 (er)-5.9 ( )11.3 (J)-2 (H)2.5 (.)-6.5 ( )]TJ 0 -1.152 Td [(Lev)8.9 (ot)-6.6 (hy)8.8 (r)-5.9 (ox)-2 (i)2.7 (ne dos)-2 (e r)-5.9 (e)10.5 (q)-11.2 (u)10.5 (i)2.6 (r)-6 (em)-6 (ent)-6.7 (s)8.9 ( )11.3 (f)-6.6 (or)4.9 ( t)-6.6 (hy)8.9 (r)-6 (ot)4.3 (r)-5.9 (opi)2.7 (n )]TJ -0.004 Tw [(s)8.9 (uppr)-6 (es)-2 (s)-2 (i)2.7 (on )-10.6 (i)2.6 (n t)-6.6 (he )]TJ 0.007 Tw 0 -1.141 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( di)13.4 (f)-6.5 (f)-6.6 (e)10.5 (r)-6 (ent)-6.6 (i)2.6 (at)-6.6 (e)10.5 (d t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (d c)-2 (anc)-2 (e)10.5 (r)-5.9 (.)4.2 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab )]TJ 0.002 Tw 0 -1.152 Td [(1992;)-6.6 (75:)-6.6 (344)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(350.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (1639933)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 278.52 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 276.48 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 254.88 Tm [(299.)-6.7 ( S)2 (al)2.6 (am)-5.9 (a)10.5 ( J)-2 (K)1.9 (,)4.3 ( )11.3 (G)-6.6 (ol)2.6 (den )11.2 (D)24.4 (W)-36.3 (,)4.3 ( Y)2 (o)10.5 (m)-6 ( S)2 (S)12.8 (,)-6.6 ( )]TJ [(e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( A)2 (C)2.6 (R)2.6 ( A)2 (ppr)-6 (opr)-5.9 (i)2.6 (a)10.5 (t)-6.6 (enes)-2 (s)-2 ( )]TJ 0 -1.152 Td [(C)2.6 (r)-5.9 (i)2.6 (t)-6.6 (er)-5.9 (i)2.6 (a\()-5.9 (R)2.6 (\))4.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )0.5 (c)-2 (a)10.5 (r)-6 (c)-2 (i)2.6 (n)10.6 (om)-5.9 (a.)4.3 ( O)4.2 (r)-5.9 (al)2.6 ( )11.3 (O)-6.6 (nc)-2 (ol)2.6 ( 2014)10.5 (;)-6.6 (5)10.5 (0:)-6.7 (577)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 24.207 0 Td [(586)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -24.207 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24824115)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 229.56 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 227.52 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 205.92 Tm [(300.)-6.7 ( P)2 (ow)13.4 (el)2.6 (l)2.6 ( C)2.6 (,)-6.6 ( N)2.6 (ew)13.5 (bol)2.7 (d )-10.5 (K)2 (,)-6.6 ( H)2.6 (ar)5 (r)-6 (i)2.6 (ngt)-6.6 (on K)2 (J)8.9 (,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( E)12.8 (x)8.9 (t)]TJ 22.598 0 Td [(er)-6 (nal)2.6 ( beam)4.9 ( )]TJ -22.598 -1.141 Td [(r)-6 (adi)2.7 (ot)-6.6 (her)-5.9 (apy)8.8 ( )11.3 (f)-17.5 (o)10.6 (r)-6 ( di)13.5 (f)-6.6 (f)-6.6 (e)10.5 (r)-5.9 (ent)-6.6 (i)13.4 (at)-6.6 (ed )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (.)-6.6 ( C)2.6 (l)2.6 (i)2.6 (n )11.3 (O)-6.7 (nc)-2 (ol)2.6 ( )11.2 (\()-5.9 (R)2.6 ( C)2.6 (ol)2.6 (l)2.7 ( R)2.6 (adi)2.6 (ol)2.6 (\))-5.9 ( )]TJ 0.002 Tw 0 -1.152 Td [(2010;)-6.6 (22:)-6.6 (456)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(463.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.7 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (20427166)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 168 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 165.96 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 144.36 Tm [(301.)-6.7 ( B)2 (i)2.6 (er)4.9 (m)-6 (ann M)15.8 (,)-6.6 ( P)1.9 (i)2.6 (x)8.9 (ber)-6 (g M)15.8 (K)1.9 (,)-6.6 ( S)2 (c)-2 (huc)]TJ 16.62 0 Td [(k)-2 ( A)2 (,)4.2 ( et)4.2 ( al)2.6 (.)4.2 ( M)5 (ul)2.6 (t)-6.6 (i)2.6 (c)-2 (ent)-6.6 (er)4.9 ( s)-2 (t)-6.6 (udy)8.9 ( )]TJ -16.62 -1.152 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (a)10.5 (r)5 (c)-2 (i)2.6 (nom)-6 (a \()-6 (M)15.8 (S)2 (D)2.6 (S)1.9 (\))-5.9 (.)-6.6 ( D)2.6 (i)2.6 (m)-6 (i)2.6 (ni)2.6 (s)8.9 (hed ac)-2 (c)-2 (ept)-6.6 (a)10.5 (nc)-2 (e o)10.5 (f)-6.6 ( )]TJ 0 -1.141 Td [(adj)-8.3 (uv)8.9 (ant)-6.6 ( ex)8.9 (t)-6.6 (er)-5.9 (nal)2.6 ( bea)10.5 (m)4.9 ( r)5 (adi)2.7 (ot)-6.6 (her)-5.9 (apy)8.8 (.)-6.6 ( N)2.6 (u)10.6 (k)-12.9 (l)2.6 (ear)4.9 (m)-5.9 (e)10.5 (di)2.6 (z)-2 (i)2.7 (n 2003;)-6.6 (42:)-6.6 (244)]TJ 0 Tc 0 Tw 29.413 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(250.)4.2 ( )]TJ 0.007 Tw -29.75 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw [(h)17.6 (ttp)17.5 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)]TJ -0.002 Tc 0.002 Tw 13.293 0 Td [(l)2.6 (m)-5.9 (.)-6.7 (ni)2.6 (h.)4.2 (g)-11.2 (ov)8.8 (/)-6.6 (pub)10.6 (m)-6 (ed)10.6 (/)-6.6 (14668957)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 106.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 104.28 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 82.68 Tm [(302.)-6.7 ( Fa)10.5 (r)-6 (ahat)-6.6 (i)2.6 ( J)8.8 (,)4.3 ( R)2.6 (ei)2.6 (ner)-6 (s)-2 ( )11.3 (C)2.6 (,)-6.6 ( S)1.9 (t)-6.5 (us)8.9 (c)-2 (h)10.5 (k)-12.9 (e M)15.8 (,)-6.6 ( e)10.6 (t)-6.6 ( al)2.6 (.)4.3 ( D)2.6 (i)13.5 (f)-6.6 (f)-6.6 (er)-6 (ent)-6.5 (i)2.6 (at)-6.6 (ed)10.5 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.141 Td [(c)-2 (anc)-2 (er)-6 (.)4.3 ( I)4.2 (m)-5.9 (pac)8.9 (t)-6.7 ( o)10.6 (f)-6.6 ( ad)10.5 (j)-8.2 (uv)8.9 (ant)-6.6 ( ex)8.9 (t)-6.6 (er)-5.9 (nal)2.6 ( )11.3 (r)-6 (adi)2.6 (ot)-6.6 (he)10.6 (r)-6 (apy)8.9 ( i)2.6 (n pat)-6.6 (i)2.6 (ent)-6.5 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ 0 -1.141 Td [(per)-6 (i)2.7 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (dal)2.6 ( t)-6.6 (um)-5.9 (o)10.5 (r)-6 ( i)2.7 (n)10.5 (f)-17.5 (i)2.6 (l)2.6 (t)4.3 (r)4.9 (at)-6.7 (i)2.7 (on \()-6 (s)8.9 (t)-6.6 (a)10.5 (g)-11.2 (e p)10.6 (T4\))4.9 (.)-6.6 ( C)2.6 (anc)-2 (e)10.5 (r)-5.9 ( 1996)10.6 (;)-6.6 (77:)-6.6 (172)]TJ 0 Tc 0 Tw 27.75 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(180.)4.2 ( )]TJ 0.007 Tw -28.087 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (8630926)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 309.12 44.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 42.72 222.48 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(303.)-6.7 ( S)2 (i)2.6 (m)-5.9 (ps)-2 (on)10.5 ( )22.1 (W)-25.4 (J)8.9 (,)4.3 ( P)1.9 (anz)8.9 (ar)-6 (el)2.7 (l)2.6 (a T,)-6.6 ( C)2.6 (a)10.6 (r)-6 (r)-6 (u)10.6 (t)-6.6 (her)-6 (s)8.9 ( J)-2 (S)1.9 (,)4.3 ( )11.3 (et)-6.6 ( al)2.6 (.)4.2 ( P)2 (api)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( and )]TJ 0 -1.152 Td [(f)-6.6 (ol)2.7 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (d c)-2 (anc)-2 (er)4.9 (:)4.3 ( i)2.6 (m)-5.9 (pac)-2 (t)4.3 ( o)10.5 (f)-6.6 ( t)4.2 (r)-5.9 (ea)10.6 (t)-6.7 (m)-5.9 (en)10.6 (t)-6.6 ( i)2.6 (n 15)10.5 (78 pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 (.)4.2 ( I)-6.6 (n)10.6 (t)-6.7 ( J)8.9 ( R)2.6 (adi)2.6 (at)-6.6 ( )]TJ 0 -1.141 Td [(O)-6.6 (nc)-2 (ol)2.6 ( B)2 (i)2.6 (ol)2.6 ( P)2 (hy)8.9 (s)-2 ( )]TJ 0.002 Tw [(1988;)-6.6 (14)10.5 (:)-6.6 (1063)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.75 0 Td [(1075)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -13.75 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (2454902)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 473.88 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 452.28 Tm [(304.)-6.7 ( C)2.7 (hen P)2 (V)12.8 (,)-6.6 ( )11.3 (O)-6.6 (s)-2.1 (bo)10.5 (r)-5.9 (ne )11.2 (R)2.6 (,)-6.5 ( A)1.9 (hn E)12.8 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( )0.5 (A)1.9 (dj)-8.3 (uv)8.8 (ant)4.3 ( ex)8.9 (t)-6.6 (er)-5.9 (nal)]TJ 0 Tc 0 Tw 25.543 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(bea)10.5 (m)-5.9 ( )]TJ 0.007 Tw -25.88 -1.141 Td [(r)-6 (adi)2.7 (ot)-6.6 (her)-5.9 (apy)8.8 ( i)2.6 (n pa)10.6 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( )11.3 (w)2.6 (i)2.6 (t)-6.6 (h hi)2.6 (g)-11.2 (h)]TJ 0 Tc 0 Tw 14.565 0 Td (-)Tj -0.005 Tc 0.01 Tw 0.337 0 Td [(r)-9 (is)5.9 (k)-5 ( w)10.5 (e)-3.4 (ll)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 3.859 0 Td [(di)2.6 (f)-6.6 (f)-17.5 (er)-5.9 (e)10.5 (nt)-6.6 (i)2.7 (at)-6.6 (e)]TJ -0.004 Tw [(d t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )-10.5 (c)-2.1 (anc)-2.1 (e)10.6 (r)-6 (.)4.3 ( )]TJ 0.007 Tw -18.761 -1.152 Td [(E)2 (ar)-5.9 ( N)2.6 (os)-2 (e )11.2 (T)-10.5 (h)10.5 (r)-6 (oat)4.3 ( J)8.9 ( 2009;)4.2 (88:)-6.7 (E)2 (01.)4.3 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (ab)-11.2 (l)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 0 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19623515)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 412.32 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 390.72 Tm [(305.)-6.7 ( S)2 (c)-2 (hw)13.4 (ar)-6 (t)-6.6 (z)8.9 ( D)2.6 (L,)4.2 ( Lobo )11.3 (M)15.8 (J)-2 (,)-6.6 ( A)1.9 (ng)-11.2 ( K)1.9 (K)12.9 (,)-6.7 ( e)10.6 (t)-6.7 ( )0.5 (al)2.6 (.)4.3 ( P)1.9 (os)-2 (t)-6.6 (o)10.5 (per)-5.9 (at)-6.6 (i)2.6 (v)8.9 (e ex)8.8 (t)-6.6 (er)-6 (nal)2.6 ( )0.5 (beam)4.9 ( )]TJ -0.004 Tw 0 -1.152 Td [(r)-6 (adi)2.7 (ot)-6.6 (her)-5.9 (apy)8.8 ( f)-17.5 (o)10.6 (r)-6 ( )-10.6 (d)]TJ 0.007 Tw [(i)13.5 (f)-6.6 (f)-6.6 (e)10.5 (r)-5.9 (ent)-6.6 (i)13.5 (at)-6.6 (ed )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (:)-6.6 ( ou)10.5 (t)-6.6 (c)8.8 (om)-6 (es)-2 ( and)10.5 ( )11.3 (m)-6 (or)-6 (bi)2.6 (di)2.7 (t)-6.7 (y)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ 0 -1.141 Td [(c)-2 (on)10.5 (f)-17.5 (or)4.9 (m)-6 (al)2.6 ( )11.2 (t)-6.6 (r)-5.9 (ea)10.5 (t)-6.5 (m)-6 (en)10.6 (t)-6.6 (.)4.2 ( I)-6.6 (n)10.5 (t)-6.6 ( )11.3 (J)-2 ( R)2.6 (adi)2.6 (at)-6.6 ( )11.2 (O)-6.6 (nc)-2 (ol)2.6 ( B)2 (i)2.6 (ol)2.7 ( P)1.9 (hy)8.8 (s)-2 ( 2009;)-6.6 (74)10.5 (:)-6.6 (1083)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 28.489 0 Td [(1091)10.5 (.)-6.6 ( )]TJ 0.007 Tw -28.489 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (19095376)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 350.76 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 405 329.16 Tm [(306.)-6.7 ( T)-10.5 (e)10.5 (r)-6 (ez)]TJ 0.007 Tw 4.761 0 Td [(ak)-12.9 (i)2.6 (s)-2 ( S)1.9 (A)12.9 (,)-6.6 ( Lee)10.5 ( )11.3 (K)1.9 (S)2 (,)-6.6 ( G)-6.7 (ho)10.5 (s)-2 (s)-2 (ei)2.6 (n R)2.7 (A)1.9 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( )11.3 (R)2.6 (ol)2.7 (e o)10.5 (f)-17.5 ( ex)8.9 (t)-6.6 (er)-6 (nal)2.6 ( be)10.5 (am)4.9 ( )]TJ -4.761 -1.152 Td [(r)-6 (adi)2.7 (ot)-6.6 (her)-5.9 (apy)8.8 ( i)2.6 (n pa)10.6 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( )11.3 (w)2.6 (i)2.6 (t)-6.6 (h adv)8.8 (anc)-2.1 (ed or)-5.9 ( )11.2 (r)-5.9 (ec)-2 (u)10.5 (r)-5.9 (r)-6 (e)10.6 (nt)-6.6 ( nonanapl)2.6 (as)8.9 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.141 Td [(c)-2 (anc)-2 (er)-6 (:)4.3 ( M)15.7 (em)-5.9 (or)-6 (i)2.7 (al)2.6 ( S)2 (l)2.6 (oan)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 10.804 0 Td [(k)-12.9 (e)10.6 (t)-6.7 (t)-6.6 (e)10.6 (r)-6 (i)2.6 (ng C)2.6 (anc)-2 (er)4.9 ( C)2.6 (ent)-6.6 (e)10.5 (r)-5.9 ( )11.3 (ex)8.9 (per)-6 (i)2.6 (enc)-2 (e.)-6.6 ( I)-6.6 (n)10.5 (t)-6.6 ( J)8.8 ( R)2.7 (adi)2.6 (at)-6.6 ( )]TJ -10.804 -1.152 Td [(O)-6.6 (nc)-2 (ol)2.6 ( B)2 (i)2.6 (ol)2.6 ( P)2 (hy)8.9 (s)-2 ( 2009;)-6.6 (73)10.5 (:)-6.6 (795)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.196 0 Td [(801)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -13.196 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (18676097)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 278.52 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 276.48 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 405 254.88 Tm [(307.)-6.7 ( G)-6.6 (i)2.6 (ul)2.6 (i)2.6 (ani)2.6 ( )-10.6 (M)15.8 (,)-6.6 ( )-10.6 (B)1.9 (r)-5.9 (i)2.6 (er)-5.9 (l)2.6 (ey)8.9 ( )-21.5 (J)-2 (.)-6.6 ( I)-6.6 (ndi)2.6 (c)-2 (at)-6.6 (i)2.6 (ons)-2 ( f)-6.6 (or)4.9 ( t)-6.6 (he )-10.7 (us)-2 (e)10.5 ( o)10.5 (f)-17.5 ( )-10.6 (ex)8.9 (t)-6.6 (er)-6 (nal)2.6 ( )-10.6 (be)10.5 (am)4.9 ( )]TJ 0.007 Tw 0 -1.152 Td [(r)-6 (adi)2.7 (at)-6.6 (i)2.6 (on i)2.6 (n )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (e)10.6 (r)-6 (.)4.3 ( C)2.6 (ur)-5.9 (r)4.9 ( )11.3 (O)-6.7 (pi)2.6 (n O)-6.7 (n)10.6 (c)-2 (ol)2.6 ( 2014;)4.3 (26:)-6.6 (45)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 24.772 0 Td [(50)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -24.772 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24225415)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 229.56 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 227.52 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 205.92 Tm [(308.)-6.7 ( Lee)10.6 ( E)1.9 (K)2 (,)-6.6 ( Lee)10.5 ( Y)2 (J)8.8 (,)-6.6 ( J)-2 (u)10.5 (ng Y)1.9 (S)2 (,)-6.7 ( )0.5 (e)10.5 (t)-6.6 ( al)13.5 (.)-6.6 ( P)2 (os)8.9 (t)-6.6 (oper)-5.9 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e s)-2 (i)2.6 (m)-5.9 (ul)2.6 (t)-6.6 (aneous)-2 ( )]TJ 0 -1.141 Td [(i)2.6 (nt)-6.6 (egr)-6 (at)-6.7 (ed)10.5 ( boos)8.8 (t)]TJ 0 Tc 0 Tw 7.152 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(i)2.6 (nt)-6.6 (ens)-2 (i)13.5 (t)4.2 (y)8.9 ( )-10.6 (m)-6 (odul)2.6 (at)-6.6 (ed r)-6 (adi)2.7 (at)-6.6 (i)2.6 (on t)-6.6 (h)10.5 (er)-6 (apy)8.9 ( f)-17.4 (or)4.9 ( )-10.6 (pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 (s)-2 ( )-10.6 (w)13.5 (i)2.6 (t)-6.6 (h )]TJ 0.007 Tw -7.489 -1.152 Td [(l)2.6 (oc)-2 (or)-5.9 (eg)-11.2 (i)2.6 (onal)2.6 (l)2.6 (y)8.9 ( adv)8.8 (anc)-2 (ed p)]TJ [(api)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a:)4.2 ( pr)-6 (el)2.6 (i)2.6 (m)-5.9 (i)2.6 (nar)-6 (y)8.9 ( r)-6 (e)10.6 (s)-2 (ul)2.6 (t)-6.6 (s)-2 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.141 Td [(a phas)-2 (e )11.2 (I)-6.6 (I)4.3 ( t)4.2 (r)-5.9 (i)2.6 (al)2.7 ( and p)10.5 (r)-5.9 (ope)10.5 (ns)-2 (i)2.6 (t)-6.6 (y)8.8 ( s)-2 (c)-2 (or)-6 (e anal)2.6 (y)8.9 (s)-2 (i)2.6 (s)-2 (.)-6.6 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.6 (nol)2.6 ( M)15.7 (et)-6.6 (ab )]TJ 0.002 Tw 0 -1.152 Td [(2015;)-6.6 (100:)-6.6 (1009)]TJ 0 Tc 0 Tw 6.652 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1017.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.989 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (2558)]TJ (1596)Tj EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 142.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 140.64 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 119.04 Tm [(309.)-6.7 ( E)2 (x)8.9 (per)-6 (t)4.3 ( P)1.9 (anel)2.6 ( O)-6.6 (n)10.5 ( R)2.6 (a)10.6 (di)2.6 (at)-6.6 (i)2.6 (on O)-6.6 (nc)-2 (ol)2.6 (o)10.5 (g)-11.2 (y)]TJ 0 Tc 0 Tw 18.5 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(B)2 (one )11.3 (M)15.8 (,)-6.6 ( Lut)-6.7 (z)8.9 ( S)2 (T)-10.6 (,)4.3 ( Lo S)1.9 (S)12.9 (,)-6.7 ( )0.5 (e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( )]TJ -18.837 -1.152 Td [(A)2 (C)2.6 (R)2.6 ( A)1.9 (ppr)-5.9 (opr)-6 (i)2.6 (at)-6.6 (enes)-2.1 (s)8.9 ( C)2.6 (r)4.9 (i)2.7 (t)-6.7 (er)-6 (i)2.6 (a\()-6 (R)2.7 (\))4.9 ( non)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 16.793 0 Td [(s)-2 (pi)2.6 (ne bo)10.5 (ne )11.3 (m)-5.9 (et)-6.6 (as)8.8 (t)-6.6 (as)-2 (es)8.9 (.)-6.6 ( J)8.9 ( P)1.9 (al)2.6 (l)2.6 (i)2.6 (at)-6.7 ( )]TJ -16.793 -1.141 Td [(M)15.8 (ed 2012;)-6.6 (15:)-6.6 (521)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 8.098 0 Td [(526.)4.2 ( A)12.9 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -8.098 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)]TJ -0.002 Tc 0.002 Tw 6.75 0 Td [(.)-6.6 (nl)2.7 (m)-6 (.)-6.6 (ni)2.7 (h.)4.3 (gov)8.8 (/)-6.6 (pubm)-6 (ed/)-6.6 (22536988)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 81.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 79.08 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 57.48 Tm [(310.)-6.7 ( E)2 (x)8.9 (per)-6 (t)4.3 ( P)1.9 (anel)2.6 ( on R)2.6 (a)10.5 (di)2.6 (at)-6.7 (i)2.7 (on O)-6.6 (nc)-2 (ol)2.6 (o)10.5 (g)-11.2 (y)]TJ 0 Tc 0 Tw 18.283 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(B)2 (one )11.3 (M)15.8 (,)-6.6 ( Lo S)1.9 (S)2 (,)-6.6 ( Lu)10.5 (t)-6.6 (z)8.9 ( S)2 (T,)-6.7 ( )0.5 (e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( )]TJ -18.62 -1.152 Td [(A)2 (C)2.6 (R)2.6 ( A)1.9 (ppr)-5.9 (opr)-6 (i)2.6 (at)-6.6 (enes)-2.1 (s)8.9 ( C)2.6 (r)4.9 (i)2.7 (t)-6.7 (er)-6 (i)2.6 (a \()-6 (R)13.5 (\))-5.9 ( s)-2 (pi)2.6 (nal)2.6 ( bone)10.5 ( m)-5.9 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (as)-2 (e)10.5 (s)-2 (.)4.3 ( J)-2 ( P)1.9 (al)2.6 (l)2.6 (i)2.6 (at)-6.6 ( M)15.8 (ed )]TJ EMC ET endstream endobj 1038 0 obj 27644 endobj %% Contents for page 121 %% Original object ID: 243 0 1039 0 obj << /Length 1040 0 R >> stream Q q BT /Xi119 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1040 0 obj 246 endobj %% Original object ID: 11790 0 1041 0 obj [ 2957 0 R 2958 0 R 2959 0 R 2960 0 R 2961 0 R 2962 0 R 2963 0 R 2964 0 R 2965 0 R 2966 0 R 2967 0 R 2968 0 R 2969 0 R 2970 0 R 2971 0 R 2972 0 R ] endobj %% Contents for page 122 %% Original object ID: 244 0 1042 0 obj << /Length 1043 0 R >> stream q endstream endobj 1043 0 obj 2 endobj %% Contents for page 122 %% Original object ID: 11791 0 1044 0 obj << /Length 1045 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (59)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(2013;)-6.6 (16:)-6.6 (9)]TJ 0 Tc 0 Tw 4.435 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(19.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e )-10.4 (at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -4.772 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (23167547)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 499.2 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 477.6 Tm [(311.)-6.7 ( Li)2.6 (ns)8.8 (k)-12.8 (ey)8.9 ( M)15.8 (E)1.9 (,)-6.6 ( A)2 (ndr)-6 (e)10.5 (w)13.5 (s)-2 ( D)24.4 (W)-36.3 (,)4.3 ( A)1.9 (s)-2 (her)5 ( A)1.9 (L,)4.2 ( et)4.2 ( al)2.6 (.)4.3 ( )11.2 (T)-10.5 (he)10.5 ( r)-5.9 (ol)2.6 (e o)10.5 (f)-6.6 ( s)8.9 (t)-6.6 (er)-6 (e)10.6 (ot)-6.6 (ac)8.8 (t)-6.6 (i)2.6 (c)-2 ( )]TJ 0 -1.141 Td [(r)-6 (adi)2.7 (os)-2 (ur)4.9 (g)-11.2 (er)-5.9 (y)8.8 ( i)2.6 (n )11.3 (t)-6.6 (he )11.2 (m)-5.9 (ana)10.5 (g)-11.2 (e)10.5 (m)-6 (ent)4.3 ( o)10.5 (f)-6.6 ( pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h n)10.6 (ew)2.6 (l)2.6 (y)8.9 ( di)2.6 (ag)-11.2 (nos)-2 (ed br)-6 (ai)2.6 (n )]TJ 0 -1.152 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 (:)-6.6 ( a)10.5 ( s)-2 (y)8.9 (s)-2 (t)-6.6 (e)10.5 (m)-6 (at)-6.6 (i)13.5 (c)-2.1 ( )0.5 (r)-6 (ev)8.9 (i)2.6 (ew)13.5 ( and ev)8.8 (i)2.6 (denc)-2 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 20.87 0 Td [(b)-11.2 (as)-2 (ed c)-2 (l)2.7 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( pr)-5.9 (ac)-2 (t)-6.6 (i)2.6 (c)-2 (e)10.6 ( )]TJ -20.87 -1.141 Td [(g)-11.2 (ui)2.6 (del)2.6 (i)2.6 (ne.)-6.6 ( J)8.8 ( N)2.6 (eur)-6 (oonc)-2 (ol)2.6 ( )11.3 (2010;)-6.6 (96:)-6.6 (45)]TJ 0 Tc 0 Tw 15.685 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(68.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (ab)]TJ -0.006 Tc 0.011 Tw [(l)-1.4 (e)-15.2 ( a)-4.4 (t:)-10.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw -16.022 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19960227)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 426.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 424.92 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 403.32 Tm [(312.)-6.7 ( K)2 (al)13.4 (k)-12.8 (ani)2.6 (s)-2 ( S)1.9 (N)2.7 (,)4.2 ( K)2 (ondz)8.9 (i)2.6 (ol)2.6 (k)-12.9 (a D)2.7 (,)4.2 ( )11.3 (G)-6.6 (as)-2 (par)5 ( LE)2 (,)4.2 ( et)4.2 ( al)2.6 (.)4.3 ( )11.2 (T)-10.5 (he )11.2 (r)-5.9 (ol)2.6 (e o)10.5 (f)-6.6 ( s)-2 (ur)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( )]TJ 0 -1.141 Td [(r)-6 (es)-2 (ec)-1.9 (t)-6.7 (i)2.7 (on)10.5 ( i)2.6 (n t)-6.6 (he)10.6 ( m)-6 (an)10.5 (a)10.5 (g)-11.2 (e)10.5 (m)-6 (ent)4.3 ( o)10.5 (f)-6.6 ( new)13.5 (l)-8.2 (y)8.8 ( di)2.6 (ag)-11.2 (nos)-2 (ed)10.5 ( br)-5.9 (ai)2.7 (n )11.3 (m)-6 (et)-6.6 (a)10.5 (s)-2 (t)-6.6 (as)-2 (es)8.9 (:)4.2 ( a )]TJ 0 -1.152 Td [(s)-2 (y)8.9 (s)-2 (t)-6.6 (em)-5.9 (at)-6.6 (i)2.6 (c)8.9 ( r)-6 (ev)8.8 (i)2.7 (ew)13.5 ( and ev)8.9 (i)2.6 (denc)-2 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.391 0 Td [(bas)-2 (ed c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.7 ( pr)-6 (ac)-2 (t)-6.6 (i)2.6 (c)-2 (e )11.3 (g)-11.2 (ui)2.6 (del)2.6 (i)2.6 (ne.)-6.6 ( J)8.9 ( )]TJ -14.391 -1.141 Td [(N)2.6 (eur)-5.9 (oonc)-2 (ol)2.6 ( 2010;)-6.6 (96)10.6 (:)-6.7 (33)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 10.696 0 Td [(43.)-6.6 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -10.696 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19960230)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 350.76 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 329.16 Tm [(313.)-6.7 ( C)2.7 (hi)2.6 (u A)1.9 (C)2.6 (,)4.3 ( D)2.6 (el)2.6 (pas)-2 (s)-2 (a)10.5 (nd E)2 (S)1.9 (,)-6.6 ( S)2 (he)10.5 (r)-5.9 (m)-6 (an)10.5 ( S)2 (I)4.2 (.)-6.6 ( P)12.8 (r)-5.9 (o)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)8.9 ( and )11.3 (t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-6 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.152 Td [(br)-6 (ai)2.7 (n m)-5.9 (e)10.5 (t)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)-2 ( i)2.6 (n)10.5 ( t)-6.6 (hy)8.8 (r)4.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.6 (.)-6.7 ( )11.3 (J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (n)10.6 (doc)-2 (r)-6 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab )]TJ 0.002 Tw 0 -1.141 Td [(1997;)-6.6 (82:)-6.6 (3637)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(3642.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e a)]TJ 0.005 Tc -0.005 Tw (t: )Tj EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw -6.435 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9360519)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 291.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 289.08 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 267.48 Tm [(314.)-6.7 ( D)2.7 (ur)-5.9 (an)10.5 (t)-6.6 (e C)13.5 (,)-6.7 ( H)2.6 (addy)8.9 ( )11.3 (N)2.6 (,)-6.7 ( )0.5 (B)1.9 (audi)2.6 (n E)2 (,)4.2 ( et)4.3 ( al)2.6 (.)4.3 ( Lon)10.5 (g)]TJ 0 Tc 0 Tw 21 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(t)-6.6 (er)4.9 (m)-6 ( ou)10.5 (t)-6.6 (c)-2 (o)10.5 (m)-6 (e o)10.5 (f)-6.6 ( 444)10.5 ( )]TJ -21.326 -1.141 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h di)2.6 (s)-2 (t)-6.6 (an)10.6 (t)-6.6 ( )11.2 (m)-5.9 (e)10.5 (t)4.3 (as)-2 (t)-6.6 (as)-2 (es)8.9 ( )11.3 (f)-6.7 (r)-5.9 (om)5 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( and )11.2 (f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (:)-6.6 ( b)]TJ [(ene)10.5 (f)-17.4 (i)13.4 (t)-6.6 (s)8.9 ( and l)13.4 (i)2.7 (m)-6 (i)2.6 (t)-6.6 (s)-2 ( o)10.5 (f)-6.6 ( )11.3 (r)-6 (adi)2.6 (oi)2.6 (odi)2.6 (ne t)-6.6 (her)-5.9 (a)10.5 (py)8.9 (.)-6.6 ( J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( )]TJ 0 -1.141 Td [(M)15.8 (et)-6.6 (ab 2006;)-6.6 (91:)-6.6 (2892)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.489 0 Td [(28)10.5 (99.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -9.489 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (16684830)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 216.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 214.92 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 193.32 Tm [(315.)-6.7 ( D)2.7 (r)-6 (oz)8.9 ( J)-2 (P)12.9 (,)-6.7 ( S)2 (c)-2 (hl)2.7 (um)-5.9 (b)10.5 (er)4.9 (g)-11.2 (e)10.6 (r)-6 ( M)15.8 (,)-6.6 ( R)2.6 (ou)10.6 (g)-11.3 (i)2.7 (er)-5.9 ( P)12.9 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( )11.3 (C)2.6 (he)]TJ [(m)-6 (ot)-6.6 (he)10.5 (r)-5.9 (apy)8.9 ( i)2.6 (n )]TJ 0 -1.152 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (at)-6.7 (i)2.7 (c)8.8 ( nonanapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)8.8 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-5.9 (:)4.3 ( ex)8.9 (per)-6 (i)2.6 (enc)-2 (e at)4.3 ( t)-6.6 (he)10.6 ( I)-6.7 (n)10.6 (s)-2 (t)-6.6 (i)2.6 (t)-6.6 (u)10.5 (t)-6.6 ( )]TJ 0.002 Tw 0 -1.141 Td [(G)-6.6 (us)-2 (t)-6.6 (av)8.9 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 4.054 0 Td [(R)2.6 (ous)-2 (s)-2 (y)8.9 (.)-6.6 ( T)-10.6 (u)10.5 (m)-5.9 (o)10.5 (r)-6 (i)2.6 ( )-10.6 (1990;)-6.6 (76)10.5 (:)-6.6 (480)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.13 0 Td [(483)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -17.185 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (2256195)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 155.28 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 153.24 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 131.64 Tm [(316.)-6.7 ( A)2 (hu)10.5 (j)-8.3 (a S)12.8 (,)-6.6 ( E)1.9 (r)-5.9 (n)10.5 (s)]TJ 8.315 0 Td [(t)4.3 ( H)2.6 (.)4.2 ( C)2.6 (hem)-5.9 (ot)-6.6 (he)10.5 (r)-5.9 (apy)8.8 ( o)10.6 (f)-6.7 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)8.9 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a.)4.3 ( J)8.8 ( E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( )]TJ -8.315 -1.141 Td [(I)-6.6 (nv)8.9 (es)-2 (t)-6.6 ( 1987)10.6 (;)-6.7 (10:)-6.6 (303)]TJ 0 Tc 0 Tw 8.478 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(310.)4.2 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -8.815 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (3624802)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 106.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 104.28 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 82.68 Tm [(317.)-6.7 ( S)2 (her)4.9 (m)-5.9 (an)10.6 ( S)2 (I)4.3 (.)-6.6 ( C)2.7 (y)8.8 (t)-6.6 (ot)-6.6 (o)10.5 (x)8.9 (i)2.6 (c)-2 ( c)-2 (hem)-6 (ot)-6.6 (her)-6 (apy)8.9 ( )11.3 (f)-6.6 (or)4.9 ( di)13.4 (f)-6.6 (f)-6.6 (er)-6 (ent)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( t)-6.7 (hy)]TJ 0.002 Tw 27.815 0 Td [(r)-6 (oi)2.6 (d )]TJ 0.007 Tw -27.815 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( C)2.6 (l)2.6 (i)2.6 (n )0.5 (O)4.2 (nc)-2 (ol)2.6 ( \()-5.9 (R)13.4 ( C)2.6 (ol)2.6 (l)2.6 ( R)2.6 (adi)2.6 (ol)2.6 (\))-5.9 ( 2010;)-6.6 (22:)-6.6 (46)10.5 (4)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 22.663 0 Td [(468.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.663 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (20452757)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 57.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 55.44 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(318.)-6.7 ( M)15.8 (ar)-6 (ot)-6.6 (t)-6.6 (a)10.5 ( V)1.9 (,)4.3 ( S)2 (c)-2 (i)2.6 (am)4.9 (m)5 (ar)-6 (el)2.6 (l)2.6 (a C)2.6 (,)-6.6 ( V)1.9 (i)2.6 (t)-6.6 (al)2.6 (e M)15.8 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( )11.3 (T)-10.5 (he)10.5 ( ev)8.8 (ol)2.6 (v)-2 (i)2.6 (ng)-11.2 ( )11.2 (f)-17.5 (i)2.7 (el)2.6 (d o)10.5 (f)-6.6 ( )]TJ 0.002 Tw 0 -1.152 Td [(k)-12.9 (i)2.6 (nas)-1.9 (e)]TJ 0 Tc 0 Tw 2.88 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(i)2.6 (nhi)2.6 (bi)2.6 (t)-6.6 (or)-5.9 (s)-2 ( i)2.6 (n )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (.)-6.6 ( )0.5 (C)13.4 (r)-5.9 (i)2.6 (t)-6.6 ( R)2.6 (ev)8.9 ( )11.3 (O)-6.6 (nc)-2 (ol)2.6 ( H)2.6 (em)-5.9 (a)10.5 (t)-6.6 (ol)2.7 ( 2015;)-6.7 (93)10.5 (:)-6.6 (60)]TJ 0 Tc 0 Tw (-)Tj -0.013 Tc 0.013 Tw 28.207 0 Td [(7)-11.3 (3.)-6.8 ( )]TJ -0.002 Tc 0.007 Tw -31.37 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (25240824)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 488.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 486.6 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 465 Tm [(319.)-6.7 ( C)2.7 (abani)2.6 (l)2.6 (l)2.6 (as)-2 ( )0.5 (M)15.7 (E)2 (,)-6.6 ( B)1.9 (r)-5.9 (os)-2 (e M)15.8 (S)1.9 (,)-6.6 ( H)2.6 (ol)2.6 (l)2.6 (and J)-2 (,)-6.7 ( e)10.6 (t)-6.6 ( al)2.6 (.)4.3 ( )11.3 (A)1.9 ( phas)-2 (e )11.3 (I)-6.6 ( s)8.8 (t)-6.6 (udy)8.9 ( o)10.5 (f)-6.6 ( )]TJ 0 Tc 0 Tw 0 -1.152 Td (c)Tj -0.002 Tc 0.007 Tw [(aboz)8.8 (ant)-6.6 (i)2.6 (ni)2.6 (b )0.5 (\()-6 (X)-8.9 (L184)10.6 (\))-6 ( i)2.6 (n )11.2 (pat)-6.7 (i)2.6 (ent)-6.7 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h di)13.5 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (e)10.5 (d t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-6 (.)4.3 ( )11.3 (T)-10.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ 0.002 Tw 0 -1.141 Td [(2014;)-6.6 (24:)-6.6 (1508)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1514.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (25102375)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 426.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 424.92 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 403.32 Tm [(320.)-6.7 ( S)2 (c)-2 (hl)2.6 (um)-5.9 (be)10.6 (r)4.9 (g)-11.3 (er)4.9 ( M)15.8 (,)-6.6 ( B)1.9 (r)5 (os)-2 (e M)15.8 (,)-6.6 ( E)2 (l)2.6 (i)2.6 (s)-2 (ei)2.6 ( R)2.6 (,)-6.6 ( et)]TJ 0 Tc 0 Tw 19.109 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(al)2.6 (.)4.2 ( D)2.6 (ef)-17.5 (i)2.6 (ni)2.6 (t)-6.6 (i)2.6 (on)10.6 ( and )11.3 (m)-6 (ana)10.6 (g)-11.3 (em)-6 (en)10.5 (t)4.3 ( )]TJ -0.004 Tw -19.391 -1.141 Td [(o)10.5 (f)-17.5 ( r)-5.9 (adi)2.6 (oac)-2 (t)-6.6 (i)2.6 (v)8.8 (e )-10.6 (i)2.6 (odi)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.196 0 Td [(r)-6 (e)10.6 (f)-6.6 (r)4.9 (ac)-2 (t)-6.6 (or)-6 (y)8.9 ( di)13.5 (f)-6.6 (f)-6.6 (er)-6 (en)10.6 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.3 (t)-6.6 (hy)8.9 (r)4.9 (oi)2.6 (d c)-2 (anc)-1.9 (er)4.9 (.)-6.6 ( Lanc)-2 (e)10.5 (t)-6.6 ( )]TJ -9.196 -1.152 Td [(D)2.6 (i)2.6 (abet)-6.6 (es)-2 ( E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( 201)10.5 (4;)-6.6 (2:)-6.6 (356)]TJ 0 Tc 0 Tw 14.185 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(358.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.522 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24795243)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 365.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 363.36 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 341.76 Tm [(321.)-6.7 ( A)2 (nder)4.9 (s)-2 (on R)13.5 (T,)-6.6 ( Li)2.6 (nne)10.6 (han J)-2 (E)2 (,)4.2 ( )11.3 (T)-10.6 (on)10.5 (g)-11.2 (br)-5.9 (a)10.5 (m)-5.9 ( V)12.8 (,)-6.6 ( e)10.5 (t)-6.6 ( )11.2 (al)2.6 (.)-6.6 ( C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.7 (,)-6.7 ( s)-2 (a)10.6 (f)-17.5 (e)10.5 (t)-6.6 (y)8.9 (,)-6.6 ( and )]TJ 0 -1.141 Td [(ec)-2 (onom)-5.9 (i)2.6 (c)-2 ( ev)8.9 (i)2.6 (denc)-2 (e i)2.6 (n r)-6 (a)10.5 (di)2.6 (oac)-2 (t)-6.6 (i)2.6 (v)8.9 (e i)2.6 (odi)2.7 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 17.946 0 Td [(r)-6 (e)10.6 (f)-17.5 (r)-6 (ac)8.9 (t)-6.7 (or)4.9 (y)8.9 ( )-10.6 (di)2.7 (f)-6.7 (f)-17.4 (e)10.5 (r)-6 (ent)-6.6 (i)2.6 (a)10.6 (t)-6.6 (ed t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0.007 Tw -17.946 -1.152 Td [(c)-2 (anc)-2 (er)-6 (:)4.3 ( a )11.3 (s)-2 (y)8.8 (s)-1.9 (t)-6.7 (em)-5.9 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( l)2.6 (i)2.6 (t)-6.6 (er)5 (at)-6.6 (ur)-5.9 (e)10.5 ( r)-6 (ev)8.9 (i)2.6 (ew)13.4 (.)-6.6 ( T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d 20)10.5 (13;)-6.6 (23:)-6.6 (392)]TJ 0 Tc 0 Tw 26.087 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(407.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e)-11.2 ( )]TJ -0.006 Tc 0.006 Tw -26.424 -1.141 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (23294230)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 648.96 303.84 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 420.36 301.8 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 280.2 Tm [(322.)-6.7 ( B)2 (al)2.6 (es)-2 ( S)2 (R)2.6 (,)4.2 ( C)2.6 (hopr)-5.9 (a)10.5 ( I)4.2 (J)-2 (.)-6.6 ( )11.3 (T)-10.6 (a)10.6 (r)4.9 (g)-11.3 (et)-6.6 (ed)10.5 ( t)4.2 (r)-5.9 (eat)4.2 (m)-5.9 (en)10.6 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.2 (di)2.6 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.6 (t)-6.7 (i)2.7 (at)-6.6 (ed )11.3 (and )]TJ 0 -1.152 Td [(m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (.)-6.6 ( J)8.9 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d R)2.6 (es)-2 ( )0.5 (2011)10.5 (;)-6.6 (20)10.5 (11:)-6.6 (102636.)4.3 ( A)1.9 (v)8.9 (ai)2.5 (l)2.7 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 0 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21826256)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 254.88 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 252.84 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 231.24 Tm [(323.)-6.7 ( )11.3 (G)-6.6 (i)2.6 (l)2.6 (d M)15.8 (L,)-6.6 ( B)2 (ul)2.6 (l)2.6 (oc)-2 (k)-12.9 ( M)15.8 (,)-6.6 ( )11.3 (R)2.6 (obi)2.6 (ns)-2 (on B)2 (G)-6.6 (,)4.3 ( C)2.6 (l)2.6 (i)2.6 (f)-6.6 (t)-6.6 (on)]TJ 0 Tc 0 Tw (-)Tj -0.005 Tc 0.01 Tw 20.728 0 Td [(B)-1 (li)10.4 (g)-14.2 (h)7.5 ( R.)-9.6 ( M)12.8 (u)-3.4 (lt)-9.6 (ik)-15.9 (in)-3.3 (a)-3.4 (s)-5 (e)-3.3 ( )]TJ -0.002 Tc 0.007 Tw -20.728 -1.152 Td [(i)2.6 (nhi)2.6 (bi)2.6 (t)-6.6 (or)-5.9 (s)-2 (:)-6.6 ( a)10.5 ( new)13.5 ( opt)-6.6 (i)2.6 (on )11.3 (f)-6.7 (or)-6 ( )11.3 (t)-6.6 (he )11.3 (t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-6 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (.)-6.6 ( N)2.6 (a)10.5 (t)-6.6 ( R)2.6 (ev)8.9 ( )]TJ 0 -1.141 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( 2011;)-6.6 (7:)4.3 (617)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 10.315 0 Td [(6)10.5 (24.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -10.315 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21862995)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 193.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 191.28 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 169.68 Tm [(324.)-6.7 ( K)2 (api)2.6 (t)-6.6 (ei)2.6 (j)-8.3 (n)10.5 ( E)2 (,)4.3 ( S)1.9 (c)-2 (hnei)13.4 (der)-6 ( )11.3 (T)-10.6 (C)2.6 (,)4.3 ( M)15.8 (or)-5.9 (r)-6 (eau )0.5 (H)2.6 (,)4.2 ( et)4.2 ( al)2.6 (.)4.3 ( N)2.6 (ew)13.5 ( t)-6.6 (r)-6 (eat)4.3 (m)-6 (ent)4.3 ( )]TJ 0 -1.152 Td [(m)-6 (odal)2.6 (i)2.6 (t)-6.6 (i)2.6 (es)-2 ( i)2.6 (n adv)8.9 (anc)-2 (ed t)4.3 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)-5.9 (.)4.2 ( A)2 (nn )11.3 (O)-6.7 (nc)-2 (o)10.5 (l)2.6 ( 2012;)-6.5 (23:)-6.6 (10)]TJ 0 Tc 0 Tw 27.152 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(18.)4.3 ( )]TJ 0.007 Tw -27.489 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (21471561)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 144.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 142.32 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 120.72 Tm [(325.)-6.7 ( P)2 (er)-6 (ez)8.9 ( C)2.6 (A)2 (,)4.2 ( S)2 (ant)-6.6 (os)8.8 ( E)12.9 (S)1.9 (,)-6.6 ( A)2 (r)-6 (an)10.6 (g)-11.2 (o)10.5 ( B)1.9 (A)2 (,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( N)2.6 (ov)8.8 (el)2.6 ( m)-6 (ol)2.6 (ec)-2 (ul)2.6 (ar)-6 ( )11.3 (t)-6.6 (ar)5 (g)-11.3 (e)10.6 (t)-6.6 (ed )]TJ 0 -1.152 Td [(t)-6.6 (her)-6 (api)2.7 (es)-2 ( )11.3 (f)-6.6 (or)4.9 ( r)-5.9 (e)10.5 (f)-6.6 (r)-6 (a)10.6 (c)-2 (t)-6.6 (o)10.5 (r)-6 (y)8.9 ( t)4.2 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-1.9 (er)-6 (.)4.3 ( H)2.6 (ead N)2.6 (ec)8.9 (k)-2 ( 2012;)-6.6 (34)10.6 (:)-6.6 (736)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 28.207 0 Td [(745)10.5 (.)-6.6 ( )]TJ 0.007 Tw -28.207 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (21544895)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 95.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 93.36 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 71.76 Tm [(326.)-6.7 ( )33.1 (W)-36.3 (a)10.5 (n)10.5 (g)-11.2 ( E)12.9 (,)-6.7 ( K)2 (ar)-5.9 (edan)10.6 ( )11.3 (T,)-6.6 ( P)2 (er)-6 (ez)8.8 ( C)2.6 (A)2 (.)4.2 ( N)2.6 (ew)13.5 ( i)2.6 (ns)-2 (i)2.7 (g)-11.3 (ht)-6.6 (s)8.8 ( i)2.7 (n t)-6.6 (he)10.5 ( t)4.2 (r)-5.9 (eat)4.3 (m)-6 (en)10.6 (t)-6.6 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.152 Td [(r)-6 (adi)2.7 (oi)2.6 (odi)2.6 (ne r)-5.9 (e)10.5 (f)-17.5 (r)5 (ac)-2 (t)-6.6 (o)10.5 (r)-5.9 (y)8.8 ( di)13.5 (f)-6.6 (f)-6.7 (er)-5.9 (ent)-6.7 (i)2.6 (at)-6.6 (ed)10.5 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (n)10.5 (om)-6 (as)-2 (:)4.3 ( t)-6.7 (o)10.6 ( l)2.6 (env)8.8 (at)-6.6 (i)2.6 (ni)2.6 (b and )]TJ EMC ET endstream endobj 1045 0 obj 27104 endobj %% Contents for page 122 %% Original object ID: 245 0 1046 0 obj << /Length 1047 0 R >> stream Q q BT /Xi120 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1047 0 obj 246 endobj %% Original object ID: 11809 0 1048 0 obj [ 2973 0 R 2974 0 R 2975 0 R 2976 0 R 2977 0 R 2978 0 R 2979 0 R 2980 0 R 2981 0 R 2982 0 R 2983 0 R 2984 0 R 2985 0 R 2986 0 R 2987 0 R ] endobj %% Contents for page 123 %% Original object ID: 246 0 1049 0 obj << /Length 1050 0 R >> stream q endstream endobj 1050 0 obj 2 endobj %% Contents for page 123 %% Original object ID: 11810 0 1051 0 obj << /Length 1052 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (60)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(bey)8.9 (ond.)-6.6 ( A)2 (nt)-6.6 (i)2.6 (c)-2 (anc)-1.9 (er)4.9 ( D)2.6 (r)-5.9 (u)10.5 (gs)-2 ( 2015;)-6.7 (26)]TJ 0.002 Tw 15.348 0 Td [(:)-6.6 (689)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 2.283 0 Td [(697)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -17.63 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (25974026)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 499.2 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 477.6 Tm [(327.)-6.7 ( S)2 (t)4.3 (j)-8.3 (epanov)8.8 (i)2.7 (c)-2.1 ( )0.5 (N)2.6 (,)4.2 ( C)2.6 (apdev)8.9 (i)-8.3 (l)2.7 (a J)-2 (.)-6.6 ( M)15.8 (ul)2.7 (t)-6.7 (i)2.7 (k)-12.9 (i)2.6 (nas)-2 (e i)2.7 (nhi)13.4 (bi)2.6 (t)-6.6 (or)-6 (s)-2 ( i)2.6 (n)10.5 ( t)-6.6 (he)10.5 ( t)4.2 (r)-5.9 (eat)4.3 (m)-6 (ent)4.3 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 (:)-6.7 ( s)-2 (pe)10.5 (c)-2 (i)13.5 (f)-17.5 (i)2.6 (c)-2 ( )11.3 (r)4.9 (ol)2.6 (e o)10.6 (f)-17.5 ( l)2.6 (env)8.9 (at)-6.6 (i)2.6 (ni)2.7 (b.)-6.6 ( B)2 (i)2.6 (ol)2.6 (og)]TJ 21 0 Td [(i)2.6 (c)8.9 (s)-2 ( 2014;)-6.6 (8)10.5 (:)-6.6 (129)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 6.815 0 Td [(139)10.5 (.)-6.6 ( )]TJ 0.007 Tw -27.815 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (24748771)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 452.28 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 450.24 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 428.64 Tm [(328.)-6.7 ( S)2 (c)-2 (hl)2.6 (um)-5.9 (be)10.6 (r)4.9 (g)-11.3 (er)4.9 ( M)15.8 (,)-6.6 ( )11.2 (Tahar)-5.9 (a M)15.8 (,)-6.6 ( )22.1 (W)-36.3 (i)13.5 (r)5 (t)-6.7 (h L)10.5 (J)-2 (,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( )11.3 (Lenv)8.8 (at)-6.6 (i)2.6 (ni)2.7 (b v)8.9 (er)-5.9 (s)-2 (us)-2 ( )]TJ 0 -1.141 Td [(pl)2.6 (ac)-2 (ebo i)2.6 (n r)-5.9 (adi)2.6 (oi)2.7 (odi)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 10.033 0 Td [(r)-6 (e)10.6 (f)-6.6 (r)-6 (ac)8.8 (t)-6.6 (or)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (an)10.5 (c)-2 (er)4.9 (.)-6.6 ( )11.3 (N)]TJ 0 Tc 0 Tw 12.011 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(E)2 (ng)-11.2 (l)2.6 ( J)-2 ( )-10.6 (M)15.8 (ed )]TJ 0.002 Tw -22.326 -1.152 Td [(2015;)-6.6 (372:)-6.6 (621)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(630.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (25671254)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 390.72 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 388.68 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 367.08 Tm [(329.)-6.7 ( )11.3 (G)-6.6 (r)-5.9 (ube)10.5 (r)-6 ( J)8.9 (J)-2 (,)4.2 ( )0.5 (C)2.6 (ol)2.6 (ev)8.9 (as)-2 ( A)2 (D)2.6 (.)-6.6 ( D)2.6 (i)13.5 (f)-6.7 (f)-17.4 (e)10.5 (r)-6 (ent)-6.6 (i)2.6 (at)-6.6 (ed)10.6 ( )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d c)-2 (anc)-2 (er)4.9 (:)-6.6 ( )11.2 (f)-6.6 (oc)-2 (us)8.9 ( on )]TJ -0.004 Tw 0 -1.152 Td [(em)-6 (er)5 (g)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( t)-6.6 (r)-5.9 (ea)10.6 (t)4.2 (m)-5.9 (ent)-6.7 (s)8.9 ( f)-17.5 (o)10.5 (r)-5.9 ( r)-5.9 (adi)2.6 (oac)-2 (t)-6.6 (i)2.6 (v)8.9 (e )-10.6 (i)2.6 (odi)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 18.946 0 Td [(r)-6 (e)10.6 (f)-17.5 (r)4.9 (ac)-2 (t)4.2 (or)-6 (y)8.9 ( )-10.6 (pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 (.)-6.7 ( O)-6.6 (nc)-2 (ol)2.6 (o)10.5 (g)-11.2 (i)2.6 (s)-2 (t)4.3 ( )]TJ 0.002 Tw -18.946 -1.141 Td [(2015;)-6.6 (20:)-6.6 (113)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(126.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.7 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -5.88 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)6.6 (l)9.6 (m)1.1 (.n)6.6 (i)]TJ -0.002 Tc 0.002 Tw 9.696 0 Td [(h.)4.2 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (25616432)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 329.16 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 327.12 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 305.52 Tm [(330.)-6.7 ( D)2.7 (adu R)13.5 (,)-6.6 ( D)2.6 (ev)8.9 (i)2.6 (ne C)2.6 (,)-6.6 ( )11.3 (H)2.6 (er)-6 (nandez)8.8 ( M)15.8 (,)-6.6 ( et)-6.6 ( al)2.6 (.)4.3 ( R)2.6 (ol)2.6 (e o)10.5 (f)-6.6 ( s)-2 (al)2.6 (v)8.8 (ag)-11.2 (e )11.3 (t)-6.6 (ar)4.9 (g)-11.2 (e)10.6 (t)-6.6 (ed )]TJ 0 -1.152 Td [(t)-6.6 (her)-6 (apy)8.9 ( i)2.6 (n di)13.5 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.6 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.3 (t)4.3 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)-6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)2.6 (ho )11.3 (f)-17.5 (ai)2.7 (l)2.6 (ed )11.2 (f)-17.5 (i)13.5 (r)-5.9 (s)-2 (t)]TJ 0 Tc 0 Tw 27.37 0 Td (-)Tj -0.005 Tc 0.005 Tw 0.337 0 Td [(lin)-3.3 (e)-3.4 ( )]TJ -0.002 Tc 0.007 Tw -27.707 -1.141 Td [(s)-2 (or)-6 (a)10.5 (f)-17.5 (eni)2.7 (b.)4.3 ( J)8.8 ( C)2.7 (l)2.5 (i)2.7 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2014;)-6.6 (99:)-6.6 (2086)]TJ 0 Tc 0 Tw 21.554 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(2094.)-6.6 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -21.88 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24628550)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 267.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 265.44 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 243.84 Tm [(331.)-6.7 ( C)2.7 (abani)2.6 (l)2.6 (l)2.6 (as)-2 ( )0.5 (M)15.7 (E)2 (,)-6.6 ( S)1.9 (c)-2 (hl)2.6 (um)-6 (ber)4.9 (g)-11.2 (er)4.9 ( M)15.8 (,)-6.7 ( J)-2 (ar)-6 (z)8.9 (ab B)2 (,)4.2 ( )11.3 (et)-6.7 ( al)2.6 (.)4.3 ( A)1.9 ( phas)-2 (e)10.5 ( 2 )11.2 (t)-6.6 (r)-5.9 (i)2.6 (al)2.6 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.141 Td [(l)2.6 (env)8.9 (at)-6.6 (i)2.6 (ni)2.6 (b \()-6 (E)2 (7080\))-6 ( i)2.6 (n adv)8.9 (anc)-2 (ed,)-6.6 ( p)10.6 (r)-6 (o)10.5 (g)-11.2 (r)-5.9 (es)8.9 (s)-2 (i)2.6 (v)8.9 (e,)-6.6 ( r)-5.9 (adi)13.4 (oi)2.6 (odi)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc -0.004 Tw 25.141 0 Td [(re)16.6 (f)-11.5 (ra)5.7 (c)14.8 (t)-0.6 (o)5.7 (ry)14.9 (,)10.3 ( )]TJ -0.002 Tc 0.007 Tw -25.141 -1.152 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (an)10.5 (c)-2 (er)-6 (:)4.2 ( A)2 ( c)-2 (l)]TJ 14.522 0 Td [(i)2.6 (ni)2.6 (c)-2 (al)2.6 ( out)-6.6 (c)-2 (o)10.6 (m)-6 (es)8.8 ( )11.3 (and bi)2.6 (om)-6 (ar)4.9 (k)-2 (er)4.9 ( )]TJ -14.522 -1.141 Td [(as)-2 (s)-2 (es)-2 (s)-2 (m)-5.9 (en)10.5 (t)-6.6 (.)4.3 ( C)2.6 (anc)-2 (er)5 ( 201)10.5 (5;)-6.6 (121:)-6.6 (2749)]TJ 0 Tc 0 Tw 16.011 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(2756.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -16.348 -1.141 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (25913680)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.76 193.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 191.28 234.24 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 169.68 Tm [(332.)-6.7 ( )11.3 (T)-10.5 (aha)10.5 (r)-6 (a M)15.8 (,)-6.6 ( S)1.9 (c)-2 (hl)2.6 (um)-5.9 (b)10.5 (er)4.9 (g)-11.3 (er)4.9 ( M)15.8 (,)-6.6 ( E)1.9 (l)2.6 (i)2.7 (s)-2 (ei)2.6 ( R)2.6 (,)-6.6 ( et)4.2 ( al)2.6 (.)-6.6 ( E)12.8 (x)8.9 (pl)2.6 (or)-6 (at)-6.6 (or)-5.9 (y)8.8 ( anal)2.6 (y)8.9 (s)]TJ -0.005 Tc 0.01 Tw 29.457 0 Td [(is)-5 ( o)-3.4 (f)-20.5 ( )]TJ -0.002 Tc 0.007 Tw -29.457 -1.152 Td [(bi)2.6 (om)-5.9 (ar)4.9 (k)-12.8 (er)4.9 (s)-2 ( as)-2 (s)-2 (o)10.5 (c)-2 (i)2.6 (at)-6.6 (ed w)13.4 (i)2.7 (t)-6.7 (h c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( out)-6.6 (c)-2 (o)10.6 (m)-6 (es)-2 ( )11.2 (f)-6.6 (r)-5.9 (o)10.5 (m)-6 ( )11.3 (t)-6.6 (he s)8.9 (t)-6.6 (udy)8.8 ( o)10.6 (f)-6.7 ( l)2.6 (env)8.8 (at)-6.6 (i)2.6 (ni)2.6 (b )]TJ 0 -1.141 Td [(i)2.6 (n di)2.6 (f)-6.6 (f)-6.6 (er)-6 (en)10.6 (t)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( c)-2 (anc)-2 (e)10.5 (r)-5.9 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.7 (he )11.3 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d.)-6.6 ( E)1.9 (ur)4.9 ( J)8.9 ( C)2.6 (anc)8.9 (er)-5.9 ( 2017)10.5 (;)-6.6 (75:)-6.6 (213)]TJ 0 Tc 0 Tw 28.304 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(221.)4.2 ( )]TJ 0.007 Tw -28.641 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw [(h)17.6 (ttp)6.6 (s)15.9 (:/)11.3 (/w)20.5 (w)9.6 (w)-1.2 (.n)6.6 (c)5 (b)6.7 (i)9.6 (.n)6.7 (l)9.6 (m)11.9 (.n)6.7 (i)9.6 (h)6.6 (.)11.3 (g)-4.2 (o)6.6 (v)15.9 (/p)]TJ -0.002 Tc 0.002 Tw 19.174 0 Td [(ubm)-6 (e)10.6 (d/)-6.6 (28237867)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 320.88 131.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 129.6 234.239 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 108 Tm [(333.)-6.7 ( B)2 (r)-6 (o)10.6 (s)-2 (e M)15.8 (S)2 (,)-6.7 ( )0.5 (N)2.6 (ut)4.3 (t)-6.6 (i)2.6 (ng )11.2 (C)-8.2 (M)15.8 (,)-6.6 ( J)-2 (ar)-5.9 (z)8.8 (ab B)2 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( S)1.9 (or)4.9 (a)10.5 (f)-17.4 (eni)2.6 (b i)2.6 (n r)-6 (adi)2.6 (oac)8.8 (t)-6.6 (i)2.6 (v)8.9 (e )]TJ 0.002 Tw 0 -1.141 Td [(i)2.6 (odi)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 2.989 0 Td [(r)-6 (e)10.6 (f)-17.5 (r)-6 (ac)8.9 (t)-6.7 (or)-6 (y)8.9 (,)4.3 ( )-10.6 (l)2.6 (oc)-2 (al)2.6 (l)2.6 (y)8.9 ( )-21.5 (adv)8.9 (anc)-2 (ed )-10.6 (or)-6 ( m)-5.9 (et)-6.7 (as)8.9 (t)-6.6 (at)-6.6 (i)2.6 (c)8.9 ( di)2.6 (f)-6.6 (f)-6.6 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ 0.007 Tw -2.989 -1.152 Td [(c)-2 (anc)-2 (er)-6 (:)4.3 ( a )11.3 (r)-6 (ando)10.5 (m)-5.9 (i)2.6 (s)-2 (ed,)4.2 ( d)10.6 (oubl)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.457 0 Td [(bl)2.6 (i)2.6 (nd,)-6.6 ( phas)-2 (e 3)10.5 ( t)4.3 (r)-6 (i)2.6 (al)2.6 (.)-6.6 ( Lanc)-2 (e)10.5 (t)-6.6 ( 2014)10.5 (;)-6.6 (384)10.5 (:)-6.6 (319)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw -13.457 -1.141 Td [(328.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.2 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)-6.6 (g)-11.2 (ov)8.9 (/)-6.6 (pu)10.5 (bm)-5.9 (ed/)-6.6 (24768112)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 339.72 70.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 111.12 68.04 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(334.)-6.7 ( S)2 (c)-2 (hnei)2.6 (der)4.9 ( )11.3 (T)-10.6 (C)2.6 (,)4.3 ( A)1.9 (bd)10.5 (ul)2.6 (r)-6 (ahm)-5.9 (an R)2.6 (M)15.8 (,)-6.7 ( )0.5 (C)2.5 (or)-5.9 (s)-2 (s)8.8 (m)-5.9 (i)2.6 (t)4.2 ( )11.3 (E)2 (P)1.9 (,)-6.6 ( et)4.2 ( al)2.6 (.)4.3 ( Lon)10.6 (g)]TJ 0 Tc 0 Tw 27.913 0 Td (-)Tj -0.007 Tc 0.007 Tw 0.326 0 Td [(t)-11.6 (e)-5.4 (rm)-10.9 ( )]TJ -0.002 Tc -28.239 -1.152 Td [(anal)2.6 (y)8.8 (s)-1.9 (i)2.6 (s)-2.1 ( of)-17.5 ( )11.3 (t)-6.6 (he )11.3 (e)10.5 (f)-6.6 (f)-17.5 (i)2.6 (c)-2 (a)10.5 (c)-2 (y)8.9 ( and t)-6.6 (ol)2.6 (er)-6 (abi)2.6 (l)2.6 (i)2.6 (t)-6.6 (y)8.9 ( o)10.5 (f)-17.5 ( )11.3 (s)-2 (or)-6 (a)10.5 (f)-6.6 (eni)2.6 (b i)2.6 (n )0.5 (adv)8.8 (anc)-2 (ed r)-5.9 (adi)2.6 (o)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 0 -1.141 Td [(i)2.6 (odi)2.6 (ne r)-5.9 (e)10.5 (f)-17.5 (r)-5.9 (a)10.5 (c)-2 (t)-6.6 (o)10.5 (r)-6 (y)8.9 ( di)2.6 (f)]TJ -0.004 Tw 8.478 0 Td [(f)-6.6 (er)-6 (en)10.6 (t)4.2 (i)2.6 (at)-6.6 (ed )-10.6 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (c)-2 (a)10.5 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (:)-6.6 ( f)-17.5 (i)2.6 (nal)2.6 ( r)-6 (es)-2 (ul)2.6 (t)-6.6 (s)8.9 ( )-10.6 (o)10.5 (f)-6.6 ( )-10.6 (a phas)-2 (e I)-6.6 (I)4.3 ( )]TJ 0.007 Tw -8.478 -1.152 Td [(t)-6.6 (r)-6 (i)2.6 (al)2.6 (.)-6.6 ( E)1.9 (u)10.6 (r)-6 ( J)8.9 ( E)1.9 (ndoc)-2 (r)-6 (i)2.7 (nol)2.6 ( 20)10.5 (12;)-6.7 (167:)-6.6 (643)]TJ 0 Tc 0 Tw 15.848 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(650.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)-8.2 (e at)4.2 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -16.185 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22918300)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 463.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 461.28 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 439.68 Tm [(335.)-6.7 ( M)15.8 (as)-2 (s)-2 (i)2.6 (c)-2 (ot)-6.7 (t)-6.6 (e M)15.8 (H)2.6 (,)-6.6 ( B)1.9 (r)-5.9 (a)10.5 (s)-2 (s)-2 (ar)-6 (d M)15.7 (,)-6.6 ( C)2.6 (l)2.6 (au)]TJ 0.002 Tw (de)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 18.511 0 Td [(D)2.6 (es)-2 (r)-6 (o)10.5 (c)8.9 (hes)-2 ( )-10.6 (M)15.8 (,)-6.6 ( )-10.6 (et)-6.6 ( al)2.5 (.)-6.6 ( T)-10.6 (y)8.9 (r)-6 (os)-2 (i)2.6 (ne )]TJ 0.007 Tw -18.511 -1.152 Td [(k)-12.9 (i)2.6 (nas)-1.9 (e)10.5 ( i)2.6 (nhi)2.6 (bi)2.7 (t)-6.6 (or)-6 ( )11.3 (t)-6.6 (r)-5.9 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 (s)-2 ( i)2.6 (n pa)10.6 (t)-6.7 (i)2.7 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h m)-6 (e)10.5 (t)-6.6 (as)-2 (t)4.2 (at)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.5 (r)-6 (c)-2 (i)2.7 (nom)-6 (a)10.5 (s)-2 (:)4.3 ( )]TJ 0 -1.141 Td [(a r)-5.9 (e)10.5 (t)-6.6 (r)-5.9 (os)-2 (pec)8.9 (t)-6.6 (i)2.6 (v)8.9 (e s)-2 (t)-6.6 (udy)8.9 ( o)10.5 (f)-6.6 ( t)4.2 (he )11.2 (T)-10.6 (U)2.7 (T)-10.6 (H)2.6 (Y)2 (R)2.6 (E)1.9 (F ne)10.5 (t)-6.6 (w)13.5 (or)-5.9 (k)-2 (.)-6.6 ( )11.2 (E)2 (ur)-6 ( J)8.9 ( E)1.9 (ndoc)-2 (r)-6 (i)2.6 (nol)2.6 ( )]TJ 0.002 Tw 0 -1.141 Td [(2014;)-6.6 (170:)-6.6 (575)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(582.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24424318)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 389.04 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 387 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 365.4 Tm [(336.)-6.7 ( B)2 (r)-6 (o)10.6 (s)-2 (e M)15.8 (S)2 (,)-6.7 ( )0.5 (N)2.6 (ut)4.3 (t)-6.6 (i)2.6 (ng )11.2 (C)-8.2 (M)15.8 (,)-6.6 ( S)1.9 (her)-5.9 (m)-6 (a)10.6 (n S)2 (I)4.2 (,)-6.6 ( )11.3 (et)4.3 ( al)2.6 (.)-6.6 ( R)13.5 (at)-6.6 (i)2.6 (onal)2.6 (e and )0.5 (des)-2.1 (i)13.5 (g)-11.2 (n o)10.5 (f)-6.6 ( )]TJ 0 -1.141 Td [(dec)-2 (i)2.6 (s)-2 (i)2.6 (on:)-6.6 ( a doubl)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 8.38 0 Td [(bl)2.6 (i)2.6 (nd,)4.2 ( r)-6 (andom)-6 (i)2.6 (z)8.9 (ed,)-6.6 ( )-10.6 (pl)2.6 (ac)-2 (ebo)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 12.228 0 Td [(c)-2 (o)10.5 (nt)-6.6 (r)-6 (ol)2.6 (l)2.6 (ed phas)-1.9 (e)10.5 ( I)4.2 (I)-6.6 (I)4.3 ( t)4.3 (r)-6 (i)2.6 (al)2.7 ( )]TJ -20.609 -1.152 Td [(ev)8.8 (al)2.6 (uat)-6.6 (i)2.6 (ng)-11.2 ( t)-6.6 (he)10.5 ( e)10.5 (f)-6.6 (f)-17.5 (i)13.5 (c)-2 (ac)-2 (y)8.8 ( and s)-2 (a)10.5 (f)-17.5 (e)10.6 (t)-6.7 (y)8.9 ( o)10.5 (f)-6.6 ( s)-2 (or)-6 (a)10.5 (f)-6.6 (eni)2.7 (b i)2.6 (n )11.2 (pat)-6.6 (i)2.7 (ent)-6.6 (s)-2 ( )]TJ -0.005 Tc 0.01 Tw [(w)10.5 (it)-9.6 (h)-3.3 ( lo)-3.3 (c)-5 (a)-3.4 (lly)5.9 ( )]TJ -0.002 Tc 0.007 Tw 0 -1.141 Td [(adv)8.9 (anc)-2 (ed or)-5.9 ( )11.3 (m)-6 (et)-6.6 (as)8.9 (t)-6.6 (at)-6.6 (i)2.6 (c)8.9 ( r)4.9 (adi)2.6 (oac)-2 (t)-6.6 (i)2.6 (v)8.9 (e i)2.6 (odi)2.6 (ne \()-6 (R)2.6 (A)2 (I)-6.6 (\))]TJ 0 Tc 0 Tw 20.946 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(r)4.9 (e)10.5 (f)-17.4 (r)-6 (ac)8.8 (t)-6.6 (or)-6 (y)8.9 (,)-6.6 ( di)13.5 (f)-6.6 (f)-6.6 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( )]TJ -21.272 -1.152 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 (.)-6.7 ( B)2 (M)15.8 (C)2.6 ( C)2.6 (anc)-2 (er)-6 ( 2011)10.5 (;)-6.6 (11:)-6.6 (349)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 0 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21834960)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 302.16 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 300.12 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 278.52 Tm [(337.)-6.7 ( H)2.7 (o)10.5 (f)-6.6 (t)]TJ 4.054 0 Td [(i)2.6 (j)-8.2 (z)8.8 (er)-6 ( H)13.5 (,)-6.6 ( H)2.6 (ee)10.6 (m)-6 (s)-2 (t)4.3 (r)-6 (a K)1.9 (A)2 (,)4.3 ( M)15.7 (or)-6 (r)-5.9 (eau H)2.6 (,)4.3 ( et)4.2 ( al)2.6 (.)4.2 ( )11.3 (B)2 (enef)-17.5 (i)2.6 (c)-2 (i)2.7 (al)2.6 ( e)10.5 (f)-6.6 (f)-6.6 (ec)8.9 (t)-6.7 (s)8.9 ( o)10.5 (f)-6.6 ( )]TJ -4.054 -1.141 Td [(s)-2 (or)-6 (a)10.5 (f)-17.5 (eni)2.7 (b on)10.5 ( t)4.2 (um)-6 (o)10.6 (r)-6 ( p)10.5 (r)-5.9 (o)10.5 (g)-11.2 (r)4.9 (es)-2.1 (s)-2 (i)2.7 (on,)-6.6 ( bu)10.5 (t)-6.6 ( no)10.5 (t)-6.6 ( on)10.6 ( r)-6 (adi)2.6 (oi)13.4 (odi)2.6 (ne upt)-6.6 (a)10.5 (k)-12.9 (e)10.5 (,)-6.6 ( i)2.6 (n pa)10.6 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( )]TJ 0 -1.152 Td [(w)2.6 (i)2.6 (t)-6.6 (h di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-1.9 (ar)-6 (c)-2 (i)2.7 (no)10.5 (m)-5.9 (a.)4.3 ( E)2 (ur)4.9 ( J)-2 ( E)2 (ndoc)8.9 (r)-6 (i)2.6 (nol)2.6 ( 2009;)-6.6 (161:)-6.6 (92)10.5 (3)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 30.533 0 Td [(931)10.5 (.)-6.6 ( )]TJ 0.007 Tw -30.533 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (19773371)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 240.6 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 238.56 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 216.96 Tm [(338.)-6.7 ( C)2.7 (abani)2.6 (l)2.6 (l)2.6 (as)-2 ( )0.5 (M)15.7 (E)2 (,)-6.6 ( )22.1 (W)-36.2 (a)21.4 (g)-11.3 (ues)-2 (pac)8.8 (k)-2 ( S)12.9 (G)-6.7 (,)4.3 ( B)2 (r)-6 (ons)8.9 (t)-6.6 (ei)2.6 (n )11.3 (Y)1.9 (,)-6.6 ( et)4.3 ( al)2.6 (.)4.2 ( )11.3 (T)-10.6 (r)-5.9 (ea)10.6 (t)-6.7 (m)-5.9 (en)10.6 (t)-6.6 ( w)13.4 (i)2.6 (t)-6.6 (h )]TJ 0 -1.152 Td [(t)-6.6 (y)8.9 (r)-6 (os)-2 (i)2.6 (ne )11.2 (k)-12.8 (i)2.6 (nas)-2 (e i)2.7 (nhi)2.6 (bi)2.6 (t)-6.6 (or)-6 (s)8.9 ( )11.3 (f)-17.5 (o)10.5 (r)-6 ( )0.5 (pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h di)2.6 (f)-6.6 (f)-6.6 (er)-5.9 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (:)4.3 ( t)-6.6 (he)10.5 ( )]TJ 0 -1.141 Td [(M)15.8 (.)-6.6 ( D)2.6 (.)-6.6 ( A)1.9 (nder)-6 (s)-2 (on)10.5 ( ex)8.8 (per)-5.9 (i)2.6 (enc)-2 (e.)-6.6 ( J)8.9 ( C)2.6 (l)2.6 (i)]TJ 14.565 0 Td [(n E)1.9 (ndoc)-2 (r)-6 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2010;)-6.6 (95)10.6 (:)-6.7 (2588)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 15.304 0 Td [(2595)10.5 (.)-6.6 ( )]TJ 0.007 Tw -29.87 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (20392874)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 178.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 176.88 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 155.28 Tm [(339.)-6.7 ( K)2 (l)2.6 (oos)-2 ( R)13.5 (T,)-6.6 ( R)2.6 (i)2.6 (n)10.5 (g)-11.2 (el)2.6 ( M)4.9 (D)2.6 (,)-6.6 ( K)2 (nopp M)15.7 (V)2 (,)-6.6 ( et)4.2 ( al)2.7 (.)4.2 ( P)2 (ha)10.6 (s)-2 (e I)4.3 (I)-6.6 ( )11.2 (t)-6.6 (r)-5.9 (i)2.6 (al)2.6 ( o)10.5 (f)-6.6 ( s)-2 (o)10.6 (r)-6 (a)10.5 (f)-17.4 (eni)2.6 (b)10.5 ( i)2.6 (n )]TJ 0 -1.141 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (at)-6.7 (i)2.7 (c)8.8 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d c)-2 (anc)8.9 (er)]TJ 11.076 0 Td [(.)-6.6 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n O)-6.6 (nc)-2 (ol)2.6 ( 2009)10.5 (;)-6.6 (27)10.5 (:)-6.6 (1)10.5 (675)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 12.63 0 Td [(1684.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -23.707 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19255327)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 130.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 128.04 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 405 106.32 Tm [(340.)-6.7 ( G)-6.6 (upt)-6.6 (a)]TJ 0 Tc 0 Tw 4.935 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(A)2 (br)-5.9 (a)10.5 (m)-6 (s)-2 (on)10.5 ( V)1.9 (,)4.3 ( )11.3 (T)-10.6 (r)-5.9 (ox)8.9 (el)2.7 ( A)1.9 (B)2 (,)-6.6 ( N)2.7 (el)2.6 (l)2.6 (or)-6 (e A)12.8 (,)-6.6 ( e)10.5 (t)-6.6 ( )11.3 (al)2.6 (.)-6.6 ( P)2 (has)-2 (e )11.3 (I)-6.6 (I)4.3 ( t)4.2 (r)-5.9 (i)2.6 (al)2.6 ( o)10.6 (f)-6.6 ( )]TJ -5.272 -1.141 Td [(s)-2 (or)-6 (a)10.5 (f)-17.5 (eni)2.7 (b i)2.6 (n)10.6 ( adv)8.9 (anc)-2 (ed t)-6.6 (h)10.5 (y)8.9 (r)-5.9 (oi)2.6 (d c)-2 (an)]TJ [(c)-2 (er)-5.9 (.)4.2 ( J)-2 ( C)2.7 (l)2.6 (i)2.6 (n )11.3 (O)-6.6 (nc)8.9 (ol)2.7 ( 2008;)-6.6 (26:)-6.6 (4714)]TJ 0 Tc 0 Tw 28.587 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(4719.)4.3 ( )]TJ 0.007 Tw -28.924 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (18541894)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 81.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 79.08 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 57.48 Tm [(341.)-6.7 ( C)2.7 (ar)4.9 (r)-5.9 ( LL)10.5 (,)-6.6 ( M)15.8 (ank)-12.9 (o)10.6 (f)-6.6 (f)-6.6 ( )11.2 (D)13.5 (A)2 (,)-6.7 ( )11.3 (G)-6.6 (oul)2.6 (ar)-6 (t)4.3 ( B)1.9 (H)2.7 (,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( P)1.9 (ha)10.5 (s)-2 (e I)4.2 (I)-6.6 ( s)8.9 (t)-6.6 (udy)8.8 ( o)10.6 (f)-6.6 ( dai)2.6 (l)2.6 (y)8.8 ( )]TJ 0 -1.152 Td [(s)-2 (uni)2.6 (t)-6.6 (i)2.6 (ni)2.6 (b i)2.7 (n FD)2.6 (G)]TJ 0 Tc 0 Tw 7.098 0 Td (-)Tj -0.015 Tc 0.015 Tw 0.337 0 Td [(P)-11.1 (ET)]TJ 0 Tc 0 Tw 1.924 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(po)10.5 (s)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (e,)-6.6 ( i)2.6 (odi)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 6.913 0 Td [(r)-6 (e)10.6 (f)-17.5 (r)4.9 (ac)-2 (t)-6.7 (o)10.6 (r)-6 (y)8.9 ( di)2.6 (f)-6.6 (f)-6.6 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ EMC ET endstream endobj 1052 0 obj 28917 endobj %% Contents for page 123 %% Original object ID: 247 0 1053 0 obj << /Length 1054 0 R >> stream Q q BT /Xi121 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1054 0 obj 246 endobj %% Original object ID: 11827 0 1055 0 obj [ 2988 0 R 2989 0 R 2990 0 R 2991 0 R 2992 0 R 2993 0 R 2994 0 R 2995 0 R 2996 0 R 2997 0 R 2998 0 R 2999 0 R 3000 0 R 3001 0 R 3002 0 R ] endobj %% Contents for page 124 %% Original object ID: 248 0 1056 0 obj << /Length 1057 0 R >> stream q endstream endobj 1057 0 obj 2 endobj %% Contents for page 124 %% Original object ID: 11828 0 1058 0 obj << /Length 1059 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (61)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(c)-2 (anc)-2 (er)-6 ( and)10.5 ( )11.3 (m)-6 (et)-6.6 (as)8.9 (t)-6.6 (at)-6.7 (i)2.7 (c)8.8 ( m)4.9 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-5.9 (a o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (h)10.5 (e t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d w)13.5 (i)2.6 (t)-6.6 (h )11.3 (f)-17.5 (unc)8.8 (t)-6.6 (i)2.6 (onal)2.6 ( )]TJ 0 -1.152 Td [(i)2.6 (m)-5.9 (ag)-11.2 (i)2.6 (n)10.5 (g)-11.2 ( )11.3 (c)-2 (or)5 (r)-6 (el)2.7 (at)-6.6 (i)2.6 (on.)4.3 ( C)2.6 (l)2.6 (i)2.6 (n C)2.7 (anc)-2 (er)-5.9 ( R)2.6 (es)8.9 ( 2010;)]TJ 0.002 Tw 19.011 0 Td [(16)10.5 (:)-6.6 (526)10.5 (0)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 3.924 0 Td [(5268.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.935 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (20847059)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 488.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 486.6 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 465 Tm [(342.)-6.7 ( R)2.7 (av)8.9 (aud A)2 (,)4.2 ( )0.5 (de l)2.7 (a Fo)10.5 (uc)-2 (har)-6 (di)2.6 (er)-6 (e C)13.4 (,)-6.6 ( C)2.6 (a)10.6 (r)-6 (on P)2 (,)4.2 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( A)1.9 ( )11.3 (m)-6 (ul)2.6 (t)-6.6 (i)2.6 (c)-2 (ent)-6.6 (e)10.5 (r)-5.9 ( pha)10.5 (s)-2 (e )]TJ 0 -1.152 Td [(I)-6.6 (I)4.2 ( s)-1.9 (t)-6.7 (udy)8.9 ( o)10.5 (f)-6.6 ( s)-2 (uni)2.7 (t)-6.7 (i)2.7 (ni)2.6 (b i)2.6 (n pa)10.5 (t)4.3 (i)2.6 (ent)-6.6 (s)-2 ( w)13.4 (i)2.6 (t)-6.6 (h l)2.6 (oc)-2 (al)2.6 (l)2.6 (y)8.9 ( ad)-11.2 (v)]TJ 20.043 0 Td [(anc)-2 (ed or)4.9 ( m)-6 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( )]TJ -20.043 -1.141 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed,)4.2 ( anapl)2.7 (as)-2 (t)-6.6 (i)2.6 (c)8.9 ( )11.2 (or)-6 ( )11.3 (m)-5.9 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)8.8 (i)2.7 (nom)-6 (as)-2 (:)4.2 ( m)-5.9 (a)10.5 (t)-6.6 (ur)-5.9 (e)10.5 ( dat)-6.6 (a)10.5 ( )]TJ 0 -1.152 Td [(f)-6.6 (r)-6 (o)10.6 (m)-6 ( )11.3 (t)-6.6 (he )11.2 (T)-10.5 (H)2.6 (Y)1.9 (S)2 (U)2.6 ( s)8.9 (t)-6.6 (udy)8.8 (.)-6.6 ( )11.3 (E)2 (ur)-6 ( J)8.9 ( C)2.6 (anc)-2 (er)4.9 ( 2017;)-6.6 (76)10.5 (:)-6.6 (11)10.6 (0)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 22.489 0 Td [(117.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.489 -1.141 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (2)]TJ (8301826)Tj EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.76 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 412.32 234.24 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 390.72 Tm [(343.)-6.7 ( Loc)-1.9 (a)10.5 (t)-6.6 (i)2.6 ( LD)2.6 (,)4.3 ( Li)2.7 (c)-2 (i)2.6 (t)-6.6 (r)-6 (a)10.5 ( L,)4.2 ( )11.3 (A)2 (g)-11.3 (at)-6.6 (e)10.5 ( L)10.5 (,)-6.6 ( e)10.6 (t)-6.7 ( al)2.6 (.)4.3 ( )11.2 (T)-10.5 (r)-6 (ea)10.5 (t)-6.6 (m)4.9 (ent)4.3 ( o)10.5 (f)-6.6 ( adv)8.9 (anc)-2 (ed t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (anc)-2 (er)-6 ( w)13.5 (i)2.6 (t)-6.6 (h ax)8.8 (i)2.7 (t)-6.6 (i)2.6 (ni)2.6 (b:)-6.6 ( P)1.9 (has)-2 (e 2 s)8.9 (t)-6.6 (udy)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ -0.004 Tw 0 -1.141 Td [(phar)-6 (m)-5.9 (ac)-2 (o)10.5 (k)-12.8 (i)2.6 (ne)10.5 (t)-6.6 (i)2.7 (c)-2 (/)-6.7 (pha)10.5 (r)-6 (m)-6 (a)10.6 (c)-2 (ody)8.9 (nam)-6 (i)2.6 (c)-2 ( )-10.6 (and q)-11.2 (ual)2.6 (i)2.6 (t)-6.6 (y)]TJ 0 Tc 0 Tw 20.772 0 Td (-)Tj -0.013 Tc 0.013 Tw 0.337 0 Td (of)Tj 0 Tc 0 Tw 0.826 0 Td (-)Tj 0.005 Tw 0.337 0 Td [(l)4.6 (i)4.6 (f)-15.5 (e)12.6 ( a)1.6 (sse)1.7 (ss)10.8 (m)-3.9 (e)1.6 (n)12.5 (t)-4.6 (s.)6.3 ( )]TJ -0.002 Tc 0.007 Tw -22.272 -1.141 Td [(C)2.6 (anc)-2 (er)-6 ( 2014)10.5 (;)-6.6 (120:)-6.6 (2694)]TJ 0 Tc 0 Tw 10.141 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(2)10.5 (703.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -10.478 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24844950)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 340.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 338.04 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 316.44 Tm [(344.)-6.7 ( C)2.7 (ohen E)1.9 (E)12.9 (,)-6.7 ( R)2.6 (os)-2 (en)10.5 ( L)10.5 (S)2 (,)-6.7 ( )0.5 (V)1.9 (o)10.5 (k)-12.8 (es)8.9 ( E)1.9 (E)2 (,)-6.6 ( e)10.5 (t)-6.6 ( )11.3 (al)2.6 (.)-6.6 ( A)2 (x)8.8 (i)2.6 (t)-6.6 (i)2.7 (ni)2.6 (b i)2.6 (s)-2 ( an ac)8.9 (t)-6.6 (i)2.6 (v)8.9 (e t)-6.6 (r)-5.9 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( )]TJ 0 -1.141 Td [(f)-6.6 (or)5 ( al)2.6 (l)2.6 ( hi)2.6 (s)-2 (t)-6.6 (ol)2.6 (og)-11.2 (i)2.6 (c)8.9 ( s)-2 (ubt)-6.6 (y)8.8 (pe)10.5 (s)-2 ( o)10.5 (f)-6.6 ( adv)8.9 (anc)-2 (ed t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (a)10.5 (nc)-2 (er)-5.9 (:)4.2 ( r)-6 (es)-2 (ul)13.4 (t)-6.6 (s)-2 ( )11.3 (f)-6.6 (r)-6 (o)10.6 (m)-6 ( a)10.5 ( )]TJ 0 -1.152 Td [(phas)-2 (e I)4.3 (I)-6.6 ( )11.2 (s)-2 (t)-6.6 (udy)8.9 (.)-6.6 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n O)-6.6 (n)10.5 (c)-2 (ol)2.6 ( 2008)]TJ 0.002 Tw [(;)-6.6 (26:)4.3 (4708)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 18.848 0 Td [(4713)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)-8.2 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -18.848 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (18541897)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 278.52 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 276.48 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 254.88 Tm [(345.)-6.7 ( C)2.7 (ohen E)1.9 (E)12.9 (,)-6.7 ( )11.3 (T)-10.6 (o)10.6 (r)-6 (t)-6.6 (o)10.5 (r)-5.9 (i)2.6 (c)-2 (i)2.6 ( M)15.8 (,)-6.6 ( K)1.9 (i)2.6 (m)-5.9 ( S)1.9 (,)4.3 ( et)4.3 ( al)2.7 (.)4.2 ( A)2 ( P)1.9 (has)-2 (e)10.6 ( I)4.2 (I)-6.6 ( )11.3 (t)-6.6 (r)-6 (i)2.6 (al)2.6 ( o)10.5 (f)-6.6 ( ax)8.9 (i)2.6 (t)-6.6 (i)2.6 (ni)2.6 (b i)2.7 (n )]TJ 0 -1.152 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h v)8.9 (ar)-6 (i)2.6 (ous)-2 ( hi)2.6 (s)-2 (t)4.2 (ol)2.6 (og)-11.3 (i)2.7 (c)-2 ( s)-2 (ub)10.5 (t)-6.6 (y)8.9 (pes)-2 ( o)10.5 (f)-6.6 ( adv)]TJ 20.717 0 Td [(anc)-2 (ed t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-5.9 (:)4.2 ( l)2.6 (on)10.5 (g)]TJ 0 Tc 0 Tw 11.696 0 Td (-)Tj -0.002 Tc 0.007 Tw -32.413 -1.141 Td [(t)-6.6 (er)5 (m)-6 ( ou)10.6 (t)-6.6 (c)-2 (o)10.5 (m)-6 (es)-2 ( and)10.5 ( phar)4.9 (m)-6 (ac)-2 (o)10.5 (k)-12.9 (i)2.6 (net)-6.6 (i)2.7 (c)8.8 (/)-6.6 (phar)4.9 (m)-6 (ac)-2 (ody)8.9 (nam)-6 (i)2.6 (c)-2 ( anal)2.6 (y)8.9 (s)-2 (es)-2 (.)-6.6 ( C)2.6 (anc)-2 (e)10.6 (r)-6 ( )]TJ 0 -1.141 Td [(C)2.6 (hem)-5.9 (ot)-6.6 (he)10.5 (r)-6 ( P)2 (har)4.9 (m)-6 (ac)-2 (ol)2.7 ( 2)10.5 (014;)-6.6 (74:)-6.6 (1261)]TJ 0 Tc 0 Tw 16.348 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1270.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -16.685 -1.152 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (25315258)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.76 204.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 202.2 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 23.52 180.6 Tm (34)Tj 0.007 Tw [(6.)-6.7 ( Li)2.6 (m)4.9 ( S)2 (M)15.8 (,)-6.7 ( )0.5 (C)2.6 (hang H)2.6 (,)4.2 ( )11.3 (Y)2 (oon M)15.8 (J)-2 (,)-6.6 ( et)-6.7 ( al)13.5 (.)-6.6 ( A)1.9 ( )11.3 (m)-6 (ul)2.6 (t)-6.6 (i)2.6 (c)-2 (e)10.5 (nt)-6.6 (er)4.9 (,)-6.6 ( phas)-2 (e)10.5 ( I)4.3 (I)-6.7 ( )11.3 (t)-6.6 (r)-5.9 (i)2.6 (al)2.6 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.141 Td [(ev)8.8 (er)-6 (ol)2.6 (i)2.6 (m)-6 (us)-2 ( i)2.6 (n l)2.7 (oc)-2 (al)2.6 (l)2.6 (y)8.9 ( ad)-11.2 (v)-2 (anc)-2 (ed or)5 ( m)-6 (e)10.5 (t)-6.6 (as)8.8 (t)-6.6 (at)-6.6 (i)2.6 (c)8.9 ( t)-6.7 (hy)8.9 (r)4.9 (oi)2.7 (d c)-2 (anc)-2 (er)4.9 ( o)10.5 (f)-6.6 ( al)2.7 (l)2.6 ( hi)2.6 (s)-2 (t)-6.6 (ol)2.6 (og)-11.2 (i)13.5 (c)-2 ( )]TJ 0 -1.152 Td [(s)-2 (ubt)-6.6 (y)8.9 (pes)-2 (.)-6.6 ( A)1.9 (nn)10.5 ( O)-6.6 (nc)-2 (ol)13.5 ( 20)10.5 (13;)-6.7 (24:)-6.6 (3089)]TJ 0 Tc 0 Tw 15.565 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(3094.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (a)-11.3 (bl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -15.902 -1.141 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (24050953)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.76 142.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 140.64 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 119.04 Tm [(347.)-6.7 ( S)2 (c)-2 (hnei)2.6 (der)4.9 ( )11.3 (T)-10.6 (C)2.6 (,)4.3 ( de )11.2 (W)-25.3 (i)13.4 (t)4.3 ( D)2.6 (,)4.3 ( Li)2.6 (n)10.5 (k)-12.8 (s)8.8 ( )11.3 (T)-10.6 (P)2 (,)-6.6 ( e)10.5 (t)4.3 ( al)2.6 (.)-6.6 ( E)2 (v)8.8 (er)-5.9 (ol)2.6 (i)2.6 (m)-5.9 (us)-2 ( i)2.6 (n P)1.9 (a)10.5 (t)-6.6 (i)2.7 (ent)-6.6 (s)8.8 ( )22.2 (W)-36.3 (i)13.5 (t)-6.6 (h)10.5 ( )]TJ 0 -1.152 Td [(A)2 (dv)8.9 (anc)-2 (ed Fol)2.7 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)]TJ 0 Tc 0 Tw 8.685 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(D)2.6 (er)-6 (i)-8.3 (v)8.9 (ed T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d C)2.6 (anc)-2 (er)4.9 (:)-6.6 ( R)2.6 (es)8.9 (ul)2.6 (t)-6.6 (s)-2 ( o)10.5 (f)-6.6 ( a P)1.9 (ha)10.5 (s)-2 (e )11.3 (I)-6.6 (I)4.3 ( C)2.6 (l)2.6 (i)2.6 (ni)2.7 (c)-2 (al)-8.3 ( )]TJ -9.022 -1.141 Td [(T)-10.6 (r)-5.9 (i)2.6 (al)2.7 (.)4.2 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.6 (nol)2.6 ( M)4.9 (et)-6.6 (ab 2017)10.5 (;)-6.6 (102:)-6.6 (698)]TJ 0 Tc 0 Tw 19.391 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(707.)4.2 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (ab)]TJ 0.007 Tw [(l)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -19.728 -1.141 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (27870581)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.76 81.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 79.08 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 57.48 Tm [(348.)-6.7 ( Leboul)2.6 (l)2.6 (eux)8.9 ( S)2 (,)-6.6 ( B)2 (as)8.8 (t)-6.6 (h)10.5 (ol)2.6 (t)-6.6 ( L,)4.2 ( K)2 (r)-6 (aus)-2 (e)10.6 ( )11.2 (T)-10.5 (,)4.2 ( et)4.2 ( al)2.6 (.)4.2 ( V)2 (a)10.5 (ndet)-6.6 (ani)2.6 (b i)2.6 (n l)2.6 (oc)-2 (al)2.6 (l)2.6 (y)8.9 ( )]TJ -0.004 Tw 0 -1.152 Td [(adv)8.9 (anc)-2 (ed )-10.6 (or)-5.9 ( m)-6 (et)-6.6 (as)8.9 (t)-6.7 (at)-6.6 (i)2.6 (c)8.9 ( di)2.6 (f)-6.6 (f)-6.6 (er)-6 (en)10.6 (t)-6.6 (i)2.6 (at)-6.6 (ed t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (c)-2.1 (an)10.5 (c)-2 (er)-6 (:)4.3 ( )-10.6 (a r)-5.9 (andom)-6 (i)2.6 (s)-2 (ed)10.5 (,)-6.6 ( )]TJ 0.002 Tw 34.554 42.5 Td [(doubl)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 3.326 0 Td [(bl)2.6 (i)2.6 (nd,)-6.6 ( phas)-2 (e 2)10.5 ( t)4.3 (r)-6 (i)2.6 (al)2.6 (.)-6.6 ( Lanc)-2 (et)4.3 ( )11.2 (O)-6.6 (nc)-2.1 (ol)2.6 ( 2012)10.5 (;)-6.6 (13)10.6 (:)-6.6 (897)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 20.674 0 Td [(905)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -24 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22898678)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 499.2 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 477.6 Tm [(349.)-6.7 ( C)2.7 (abani)2.6 (l)2.6 (l)2.6 (as)-2 ( )0.5 (M)15.7 (E)2 (,)-6.6 ( de )11.2 (S)2 (ouz)8.9 (a J)-2 (A)2 (,)-6.6 ( G)-6.6 (ey)8.9 (er)4.9 ( S)1.9 (,)-6.6 ( e)10.5 (t)4.3 ( al)2.7 (.)-6.7 ( C)2.6 (aboz)8.9 (ant)-6.6 (i)2.6 (ni)2.6 (b A)2 (s)-2 ( )]TJ 0 -1.141 Td [(S)2 (al)2.6 (v)8.9 (ag)-11.2 (e T)-10.6 (he)10.5 (r)-6 (apy)8.9 ( )11.3 (f)-17.5 (or)4.9 ( P)1.9 (at)-6.6 (i)13.5 (ent)-6.6 (s)-2 ( )33.1 (W)-36.3 (i)13.5 (t)-6.6 (h )11.3 (T)-10.6 (y)8.9 (r)-6 (os)-2 (i)2.6 (ne K)2 (i)2.6 (nas)8.8 (e I)-6.6 (nhi)2.6 (bi)2.6 (t)-6.6 (or)]TJ 0 Tc 0 Tw 26.37 0 Td (-)Tj -0.013 Tc 0.013 Tw 0.337 0 Td [(R)-8.4 (ef)-17.6 (r)-16.9 (a)-11.4 (c)-13 (t)-17.6 (or)-16.9 (y)-2.2 ( )]TJ -0.002 Tc 0.007 Tw -26.707 -1.152 Td [(D)2.6 (i)2.6 (f)-6.6 (f)-6.6 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d C)2.6 (a)10.6 (nc)-2 (er)-6 (:)4.3 ( R)2.6 (es)-2 (ul)2.6 (t)-6.6 (s)8.8 ( )0.5 (o)10.5 (f)-6.6 ( a M)15.8 (ul)2.6 (t)-6.6 (i)2.7 (c)-2 (ent)-6.6 (er)4.9 ( P)2 (has)]TJ -0.006 Tc 0 Tw 26.533 0 Td [(e)-4.3 ( I)-10.6 (I )]TJ -0.002 Tc 0.007 Tw -26.533 -1.141 Td [(I)-6.6 (nt)-6.6 (e)10.6 (r)-6 (nat)-6.6 (i)2.6 (onal)2.6 ( )11.3 (T)-10.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )11.2 (O)-6.6 (n)10.5 (c)-1.9 (ol)2.6 (og)-11.3 (y)8.9 ( G)4.3 (r)-6 (oup )11.3 (Tr)-6 (i)2.6 (al)2.6 (.)-6.6 ( J)8.8 ( C)2.6 (l)2.7 (i)2.6 (n O)-6.6 (nc)-1.9 (ol)13.5 ( 2017;)-6.6 (35)10.6 (:)-6.6 (3315)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 0 -1.152 Td [(3321.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (ps)8.8 (:)4.3 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.4 (.)-6.5 (nc)-2 (bi)2.6 (.)-6.7 (nl)2.6 (m)-5.9 (.)-6.7 (ni)2.6 (h.)-6.6 (g)-11.3 (ov)8.9 (/)-6.6 (p)10.5 (ubm)-6 (ed/)-6.6 (28817373)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 732.84 426.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 498.72 424.92 234.121 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 403.32 Tm [(350.)-6.7 ( B)2 (i)2.6 (bl)2.6 (e K)2 (C)2.6 (,)-6.6 ( S)1.9 (u)10.6 (m)-6 (an)10.5 ( V)1.9 (J)-2 (,)-6.6 ( M)15.8 (ol)2.6 (i)2.6 (na J)-2 (R)2.6 (,)-6.6 ( et)4.3 ( al)2.7 (.)4.2 ( E)12.9 (f)-6.7 (f)-17.4 (i)2.6 (c)-2 (a)10.5 (c)-2 (y)8.9 ( of)]TJ 0 Tc 0 Tw 23.826 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(paz)8.9 (opani)2.6 (b i)2.7 (n )]TJ -0.004 Tw -24.109 -1.141 Td [(pr)-6 (o)10.5 (g)-11.2 (r)-5.9 (es)-2 (s)-2 (i)2.6 (v)8.9 (e,)-6.6 ( r)-6 (adi)2.7 (oi)2.6 (odi)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 10.913 0 Td [(r)-6 (e)10.6 (f)-17.5 (r)4.9 (ac)-2 (t)-6.7 (o)10.6 (r)-6 (y)8.9 (,)-6.6 ( )11.3 (m)-6 (et)-6.6 (as)8.9 (t)-6.6 (at)-6.6 (i)2.6 (c)8.9 ( di)13.5 (f)-6.6 (f)-6.6 (er)-6 (ent)-6.6 (i)2.6 (at)-6.7 (ed)10.5 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ -10.913 -1.152 Td [(c)-2 (anc)-2 (er)-6 (s)8.9 (:)-6.6 ( )11.2 (r)-5.9 (es)-2 (ul)2.6 (t)-6.6 (s)8.9 ( o)10.5 (f)-6.6 ( a pha)10.5 (s)-2 (e 2 c)-2 (on)10.5 (s)-2 (or)4.9 (t)-6.6 (i)2.6 (um)-5.9 ( )11.3 (s)-2 (t)-6.7 (udy)8.8 (.)-6.6 ( L)10.5 (anc)-2 (et)-6.6 ( )11.3 (O)-6.6 (nc)-2 (ol)2.6 ( )]TJ 0.002 Tw 0 -1.141 Td [(2010;)-6.6 (11:)-6.6 (962)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(972.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -5.88 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)6.6 (l)9.6 (m)]TJ -0.002 Tc 0.002 Tw 8.641 0 Td [(.)-6.6 (ni)2.7 (h.)4.3 (gov)8.8 (/)-6.6 (pubm)-6 (ed/)-6.6 (20851682)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 350.76 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 329.16 Tm [(351.)-6.7 ( Fal)2.6 (c)-2 (hoo)10.6 (k)-2 ( G)-6.6 (S)12.9 (,)-6.6 ( M)15.8 (i)2.6 (l)2.6 (l)-8.2 (w)2.6 (ar)-6 (d M)15.8 (,)-6.6 ( H)2.6 (on)10.5 (g)-11.2 ( D)2.6 (,)4.3 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( B)1.9 (R)2.7 (A)1.9 (F i)2.6 (nhi)2.6 (bi)2.6 (t)-6.6 (or)-5.9 ( dabr)-6 (a)10.5 (f)-6.6 (eni)2.6 (b i)2.6 (n)10.5 ( )]TJ -0.004 Tw 0 -1.152 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( )-10.6 (w)13.5 (i)2.6 (t)-6.6 (h m)-6 (et)-6.6 (as)8.9 (t)-6.6 (at)-6.6 (i)2.6 (c)8.8 ( B)2 (R)2.6 (A)1.9 (F)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 13.62 0 Td [(m)-6 (ut)-6.6 (an)10.6 (t)-6.6 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d )-10.6 (c)-2 (a)10.5 (nc)-2 (er)-5.9 (.)4.2 ( T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (2015;)-6.6 (25)10.5 (:)-6.6 (71)]TJ 0 Tc 0 Tw 18.717 0 Td (-)Tj -0.002 Tc 0.007 Tw -32.337 -1.141 Td [(77.)-6.6 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw [(h)17.5 (ttp)17.5 (:/)]TJ -0.002 Tc 0.002 Tw 9.587 0 Td [(/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.2 (g)-11.2 (ov)8.9 (/)-6.7 (pubm)-6 (ed/)-6.5 (25285888)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 715.08 303.84 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 486.48 301.8 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 280.2 Tm [(352.)-6.7 ( R)2.7 (ot)-6.6 (hen)10.5 (ber)5 (g S)2 (M)15.8 (,)-6.7 ( M)15.8 (c)-12.8 (Fadden D)2.6 (G)4.3 (,)-6.6 ( P)1.9 (al)2.6 (m)-6 (e)10.6 (r)-6 ( E)2 (L)10.5 (,)-6.6 ( )11.2 (et)-6.6 ( al)2.6 (.)4.3 ( R)2.6 (edi)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (a)10.5 (t)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( )]TJ 0.002 Tw 0 -1.152 Td [(i)2.6 (odi)2.6 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 2.989 0 Td [(r)-6 (e)10.6 (f)-17.5 (r)-6 (ac)8.9 (t)-6.7 (or)-6 (y)8.9 ( B)2 (R)2.6 (A)1.9 (F V)12.9 (600E)]TJ 0 Tc 0 Tw 10.413 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(m)-6 (u)10.6 (t)-6.6 (ant)4.2 ( m)-5.9 (e)10.5 (t)-6.6 (as)8.9 (t)-6.6 (at)-6.6 (i)2.7 (c)-2.1 ( )11.3 (papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )0.5 (c)-2.1 (anc)-2 (er)-5.9 ( )]TJ -13.739 -1.141 Td [(w)2.6 (i)2.6 (t)-6.6 (h dabr)-5.9 (a)10.5 (f)-6.6 (eni)2.6 (b.)-6.6 ( C)2.6 (l)2.7 (i)2.6 (n C)2.6 (a)10.5 (nc)-2 (er)-6 ( R)2.6 (es)8.8 ( 2015;)-6.6 (21)10.5 (:)-6.6 (1028)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 21.272 0 Td [(1035.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -21.272 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (25549723)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 242.16 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 240.12 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 218.52 Tm [(353.)-6.7 ( K)2 (i)2.6 (m)4.9 ( K)2 (B)1.9 (,)4.3 ( C)2.6 (abani)2.6 (l)2.6 (l)2.7 (as)-2 ( M)4.9 (E)2 (,)-6.6 ( Laz)8.8 (ar)-6 ( A)2 (J)-2 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( C)2.6 (l)2.6 (i)2.6 (ni)-8.3 (c)-2 (al)2.6 ( r)-6 (es)-2 (pons)-2 (es)8.8 ( t)-6.6 (o)10.6 ( )]TJ 0 -1.141 Td [(v)8.9 (em)-5.9 (ur)-5.9 (a)10.5 (f)-17.5 (eni)2.6 (b i)2.6 (n pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( )11.2 (w)2.7 (i)2.6 (t)-6.6 (h m)-5.9 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 ( har)-5.9 (bo)10.5 (r)-6 (i)2.6 (ng )]TJ -0.004 Tc 0.009 Tw 0 -1.141 Td [(BR)0.6 (AF)-1.7 (\()-7.9 (V6)-2.3 (0)-2.3 (0)-2.4 (E\))-8 ( m)-8 (u)8.6 (t)-8.6 (a)]TJ -0.002 Tc -0.004 Tw 8.815 0 Td [(t)-6.6 (i)2.6 (on)10.5 (.)-6.6 ( T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )-10.7 (2013;)-6.6 (23)10.5 (:)-6.6 (1277)]TJ 0 Tc 0 Tw 11.848 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1)10.5 (283.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -21 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (23489023)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 180.6 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 178.56 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 156.96 Tm [(354.)-6.7 ( B)2 (r)-6 (o)10.6 (s)-2 (e M)15.8 (S)2 (,)-6.7 ( )0.5 (C)2.6 (abani)2.6 (l)2.6 (l)-8.3 (as)-2 ( M)15.8 (E)1.9 (,)-6.6 ( C)2.6 (ohen E)2 (E)2 (,)-6.7 ( e)10.6 (t)-6.7 ( )11.3 (al)2.6 (.)-6.6 ( )11.3 (V)1.9 (em)-6 (ur)-5.9 (a)10.5 (f)-6.6 (eni)2.6 (b i)2.6 (n pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 (s)-2 ( )]TJ 0 -1.141 Td [(w)2.6 (i)2.6 (t)-6.6 (h B)1.9 (R)2.6 (A)2 (F\()-6 (V)2 (600E)1.9 (\))]TJ 0 Tc 0 Tw 8.37 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(pos)-2 (i)13.5 (t)-6.6 (i)2.6 (v)8.9 (e m)-5.9 (et)-6.6 (as)8.9 (t)-6.6 (a)]TJ [(t)-6.6 (i)2.6 (c)-2 ( o)10.5 (r)-6 ( )11.3 (unr)-6 (es)-2 (ec)8.8 (t)-6.6 (abl)2.6 (e papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.7 (d )]TJ -8.707 -1.152 Td [(c)-2 (anc)-2 (er)-6 ( )11.3 (r)-6 (e)10.5 (f)-6.6 (r)-5.9 (ac)8.9 (t)-6.6 (or)-5.9 (y)8.9 ( t)-6.7 (o)10.6 ( r)-6 (adi)2.6 (o)10.6 (ac)-2 (t)-6.6 (i)2.6 (v)8.9 (e i)2.6 (odi)2.7 (ne:)-6.6 ( a non)]TJ 0 Tc 0 Tw 19.663 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(r)-6 (and)10.6 (om)-5.9 (i)2.6 (s)-2 (ed,)4.3 ( m)-6 (ul)2.7 (t)-6.6 (i)2.5 (c)-1.9 (en)10.5 (t)-6.6 (r)-5.9 (e)10.5 (,)-6.6 ( )]TJ 0.002 Tw -20 -1.141 Td (open)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 2.554 0 Td [(l)2.6 (abel)2.6 (,)-6.6 ( phas)-2 (e)10.6 ( 2 )11.3 (t)-6.6 (r)-6 (i)2.6 (al)2.6 (.)4.2 ( Lanc)-2 (et)4.2 ( )11.3 (O)-6.6 (nc)-2 (ol)2.6 ( 2016;)-6.6 (17)10.5 (:)-6.6 (1)10.5 (272)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 21.217 0 Td [(1282.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -23.772 -1.152 Td [(h)6.7 (ttp)6.7 (s)15.9 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.)]TJ -0.002 Tc 0.002 Tw [(nc)-2 (bi)2.7 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.2 (g)-11.2 (ov)8.8 (/)-6.6 (pubm)-6 (ed)10.5 (/)-6.6 (27460442)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 639.24 106.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 104.28 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 82.68 Tm [(355.)-6.7 ( D)2.7 (r)-6 (i)2.6 (l)2.6 (on A)12.9 (,)-6.7 ( Lae)10.6 (t)-6.6 (s)-2 (c)-2 (h)10.5 ( )11.2 (TW)-25.4 (,)15.1 ( K)1.9 (u)10.6 (m)4.9 (m)-6 (ar)4.9 ( S)2 (,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( E)12.8 (f)-6.6 (f)-6.6 (i)13.5 (c)-2 (ac)-2 (y)8.9 ( o)10.5 (f)-17.5 ( La)10.5 (r)-5.9 (ot)4.3 (r)-6 (ec)-2 (t)-6.6 (i)2.6 (ni)2.6 (b i)2.6 (n )]TJ 0 -1.141 Td [(T)-10.6 (R)2.6 (K)2 ( Fus)-2 (i)2.6 (on)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 5.609 0 Td [(P)2 (o)10.5 (s)-2 (i)2.6 (t)-6.6 (i)2.6 (v)8.9 (e C)2.6 (anc)-2 (er)-6 (s)-2 ( i)2.6 (n)10.6 ( A)2 (dul)2.6 (t)-6.6 (s)-2 ( and)10.6 ( C)2.6 (hi)2.6 (l)2.6 (dr)-6 (en.)4.3 ( N)2.6 ( E)1.9 (n)10.6 (g)-11.2 (l)2.6 ( J)8.8 ( M)15.8 (ed )]TJ 0.002 Tw -5.609 -1.141 Td [(2018;)-6.6 (378:)-6.6 (731)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(739.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.152 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (29466156)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 639.24 44.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 42.72 234.24 0.84 re f EMC endstream endobj 1059 0 obj 28753 endobj %% Contents for page 124 %% Original object ID: 249 0 1060 0 obj << /Length 1061 0 R >> stream Q q BT /Xi122 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1061 0 obj 246 endobj %% Original object ID: 11845 0 1062 0 obj [ 3003 0 R 3004 0 R 3005 0 R 3006 0 R 3007 0 R 3008 0 R 3009 0 R 3010 0 R 3011 0 R 3012 0 R 3013 0 R 3014 0 R 3015 0 R 3016 0 R 3017 0 R 3018 0 R ] endobj %% Contents for page 125 %% Original object ID: 250 0 1063 0 obj << /Length 1064 0 R >> stream q endstream endobj 1064 0 obj 2 endobj %% Contents for page 125 %% Original object ID: 11846 0 1065 0 obj << /Length 1066 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (62)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(356.)-6.7 ( C)2.7 (hou A)12.8 (,)-6.6 ( F)11.2 (r)-5.9 (as)-2 (e)10.5 (r)-5.9 ( S)1.9 (,)4.3 ( )11.3 (Toon C)24.4 (W)-36.3 (,)4.3 ( )11.2 (et)4.2 ( al)2.6 (.)4.3 ( A)1.9 ( de)10.5 (t)-6.6 (ai)2.6 (l)2.7 (ed c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (opat)-6.6 (hol)2.6 (og)-11.3 (i)2.7 (c)-2 ( )11.2 (s)-2 (t)-6.6 (udy)8.9 ( )]TJ -0.013 Tc 0.018 Tw 0 -1.152 Td [(of)-28.5 ( A)-9 (L)-11.4 (K)]TJ 0 Tc 0 Tw 3 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(t)-6.6 (r)-6 (ans)-2 (l)2.7 (oc)-2 (a)10.5 (t)-6.6 (ed papi)13.5 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a.)4.3 ( )11.3 (A)1.9 (m)-5.9 ( J)8.8 ( S)2 (ur)5 (g P)2 (at)-6.6 (hol)2.6 ( )]TJ 0.002 Tw -3.326 -1.141 Td [(2015;)-6.6 (39:)-6.6 (652)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(659.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.7 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (25501013)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 473.88 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 452.28 Tm [(357.)-6.7 ( P)2 (ar)4.9 (k)-2 ( )11.2 (G)-6.6 (,)4.3 ( K)1.9 (i)2.7 (m)4.9 ( )11.2 (T)-10.5 (H)2.6 (,)-6.6 ( Le)10.5 (e H)2.6 (O)4.3 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( S)1.9 (t)-6.6 (anda)10.5 (r)-5.9 (d i)13.5 (m)4.9 (m)-5.9 (unohi)2.6 (s)-2 (t)-6.6 (oc)-2 (he)10.5 (m)-6 (i)2.6 (s)-1.9 (t)4.2 (r)-5.9 (y)8.8 ( )]TJ 0 -1.141 Td [(e)10.5 (f)-6.6 (f)-17.5 (i)2.6 (c)-1.9 (i)2.6 (ent)-6.6 (l)2.6 (y)8.8 ( s)-2 (c)-2 (r)-5.9 (eens)8.9 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( a)10.5 (n)10.5 (apl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( l)2.6 (y)8.9 (m)-6 (phom)-6 (a )11.2 (k)-12.8 (i)2.6 (nas)8.8 (e r)-6 (ea)10.5 (r)-5.9 (r)-6 (an)10.5 (g)-11.2 (e)10.5 (m)-6 (ent)-6.6 (s)8.9 ( i)2.6 (n )]TJ 0 -1.152 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (an)10.5 (c)-2 (er)-6 (.)4.2 ( E)2 (ndoc)-2 (r)4.9 ( R)2.6 (el)2.7 (at)-6.6 ( C)2.6 (a)]TJ [(nc)-2 (e)10.5 (r)-5.9 ( 2015)10.6 (;)-6.7 (22:)-6.7 (55)]TJ 0 Tc 0 Tw 27.37 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(63.)4.3 ( )]TJ 0.007 Tw -27.707 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (25527510)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 412.32 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 390.72 Tm [(358.)-6.7 ( P)2 (er)-6 (o)10.5 (t)4.3 ( G)4.2 (,)-6.6 ( S)2 (oubey)8.9 (r)-6 (an)10.5 ( I)4.2 (,)-6.6 ( )0.5 (R)2.5 (i)2.7 (bei)2.6 (r)-6 (o A)12.8 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( I)-6.6 (de)10.5 (nt)-6.7 (i)13.5 (f)-6.6 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( a )11.3 (r)-5.9 (ec)-2 (ur)4.9 (r)-6 (ent)4.3 ( )]TJ 0 -1.152 Td [(S)2 (T)-10.6 (R)2.6 (N)2.6 (/)-6.6 (A)2 (LK)2 ( )11.2 (f)-6.6 (us)-2 (i)2.6 (on i)2.6 (n )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (as)8.9 (.)4.3 ( P)2 (Lo)]TJ -0.004 Tw [(S)2 ( O)4.3 (ne )-10.6 (2014;)-6.6 (9)10.5 (:)-6.6 (e87170.)4.3 ( )]TJ 0.007 Tw 0 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (24475247)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 365.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 363.36 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 341.76 Tm [(359.)-6.7 ( K)2 (el)2.6 (l)2.6 (y)8.8 ( LM)15.8 (,)-6.6 ( B)1.9 (ar)-6 (i)2.6 (l)2.6 (a G)-6.6 (,)4.3 ( )11.2 (Li)2.6 (u P)2 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.7 (.)4.2 ( I)-6.6 (den)10.5 (t)-6.6 (i)13.5 (f)-17.5 (i)2.6 (c)-2 (a)10.6 (t)-6.7 (i)2.7 (on o)10.5 (f)-6.6 ( t)-6.6 (he)10.5 ( t)4.3 (r)-6 (ans)8.8 (f)-17.5 (o)10.6 (r)4.9 (m)-6 (i)2.6 (ng )]TJ -0.005 Tc 0.005 Tw 0 -1.141 Td [(S)-1 (T)-13.6 (RN)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 3.054 0 Td [(A)2 (LK)2 ( )11.2 (f)-6.6 (us)-2 (i)2.6 (on as)8.9 ( a p)10.5 (ot)-6.6 (ent)-6.6 (i)2.6 (al)2.6 ( t)-6.6 (he)10.5 (r)-6 (apeu)10.5 (t)-6.6 (i)2.6 (c)]TJ 0 Tc 0 Tw 16.228 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(t)-6.6 (a)10.5 (r)4.9 (g)-11.2 (e)10.5 (t)-6.6 ( )-10.6 (i)2.6 (n t)-6.6 (he )-10.6 (a)10.6 (ggr)-6 (es)-2 (s)-2 (i)2.6 (v)8.8 (e f)-17.5 (o)10.5 (r)-5.9 (m)-6 (s)8.9 ( )]TJ 0.007 Tw -19.565 -1.152 Td [(o)10.5 (f)-17.5 ( )11.3 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 (.)-6.6 ( P)12.8 (r)-6 (oc)-2 ( N)13.5 (at)-6.6 (l)2.6 ( A)2 (c)-2 (ad S)1.9 (c)-2 (i)2.6 ( U)13.5 ( S)2 ( A)12.8 ( 2014;)4.3 (111:)-6.6 (4233)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 26.38 0 Td [(4238)10.5 (.)-6.6 ( )]TJ 0.007 Tw -26.38 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (24613930)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 303.84 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 301.8 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 280.2 Tm [(360.)-6.7 ( S)2 (her)4.9 (m)-5.9 (an)10.6 ( S)2 (I)4.3 (.)-6.6 ( )11.2 (T)-10.5 (a)10.5 (r)4.9 (g)-11.2 (et)4.3 (ed t)-6.6 (he)10.5 (r)-6 (api)2.6 (es)-2 ( )11.3 (f)-6.7 (or)4.9 ( t)]TJ 18.402 0 Td [(hy)8.8 (r)-5.9 (oi)2.6 (d t)4.2 (um)-6 (or)-6 (s)8.9 (.)-6.6 ( M)15.8 (od P)1.9 (at)-6.6 (hol)2.6 ( )]TJ -18.402 -1.152 Td [(2011;)-6.6 (24 S)2 (uppl)2.6 ( 2)10.6 (:)-6.6 (S)1.9 (44)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.652 0 Td [(52)10.5 (.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (ab)-11.2 (l)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -9.652 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21455200)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 254.88 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 252.84 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 23.52 231.24 Tm [(361.)-6.7 ( T)-10.5 (u)10.5 (t)-6.6 (t)-6.6 (l)2.6 (e )-10.6 (R)2.6 (M)15.8 (,)-6.6 ( )-10.6 (Leboeu)10.5 (f)-6.6 ( R)2.7 (.)-6.7 ( )-10.6 (I)-6.6 (nv)8.8 (es)-2 (t)-6.6 (i)13.5 (g)-11.2 (at)-6.6 (i)2.6 (onal)2.6 ( t)-6.7 (her)-6 (api)13.5 (es)-2 ( f)-17.5 (o)10.6 (r)-6 ( m)-6 (et)-6.7 (a)10.6 (s)-2 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0.002 Tw 0 -1.152 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( )]TJ 0.007 Tw 5.163 0 Td [(J)8.9 ( N)2.6 (at)-6.6 (l)2.6 ( C)2.6 (o)10.6 (m)-6 (pr)4.9 ( C)2.6 (anc)-2 ( N)2.6 (et)-6.6 (w)13.5 ( 2007;)-6.6 (5)10.5 (:)-6.6 (641)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 16.554 0 Td [(646.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -21.717 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (17623615)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 205.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 203.88 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 182.28 Tm [(362.)-6.7 ( S)2 (her)4.9 (m)-5.9 (an)10.6 ( S)2 (I)4.3 (.)-6.6 ( )11.2 (T)-10.5 (y)8.8 (r)-5.9 (os)-2 (i)13.5 (ne )11.3 (k)-12.9 (i)2.6 (nas)-2 (e i)2.6 (nhi)2.6 (bi)2.6 (t)-6.6 (or)-5.9 (s)8.8 ( and )11.3 (t)4.2 (he t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d.)-6.6 ( B)1.9 (es)8.9 (t)4.2 ( P)2 (r)-6 (ac)8.8 (t)-6.6 ( )]TJ 0 -1.141 Td [(R)2.6 (es)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab )]TJ 0.002 Tw [(2009;)-6.6 (23)10.5 (:)-6.6 (713)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 17.957 0 Td [(722)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -17.957 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19942148)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 156.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 154.92 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 133.32 Tm [(363.)-6.7 ( B)2 (r)-6 (o)10.6 (s)-2 (e M)15.8 (S)2 (,)-6.7 ( )0.5 (Fr)-6 (ene)10.5 (t)-6.6 (t)-6.6 (e)10.5 ( C)2.6 (T,)-6.6 ( K)2 (ee)10.5 (f)-6.6 (e S)2 (M)15.8 (,)-6.7 ( S)2 (t)-6.6 (ei)2.7 (n S)12.8 (M)15.8 (.)-6.6 ( )-10.5 (M)15.8 (anag)-11.2 (em)-5.9 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( )]TJ 0.002 Tw 0 -1.141 Td [(s)-2 (or)-6 (a)10.5 (f)-17.5 (eni)2.7 (b)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 4.435 0 Td [(r)-6 (el)2.6 (at)-6.6 (ed)10.5 ( adv)8.9 (er)-6 (s)-2 (e ev)8.9 (ent)-6.6 (s)-2 (:)4.2 ( a c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (i)2.6 (an')-6.7 (s)-2 ( pe)10.5 (r)4.9 (s)-2 (pec)-2 (t)-6.6 (i)2.6 (v)]TJ -0.004 Tw 20.511 0 Td [(e.)-6.7 ( )-10.6 (S)2 (em)-5.9 (i)2.6 (n O)-6.6 (nc)-2 (ol)2.6 ( )]TJ 0.007 Tw -24.946 -1.152 Td [(2014;)-6.6 (41 S)2 (uppl)2.6 ( 2)10.6 (:)-6.6 (S)1.9 (1)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.098 0 Td [(S)2 (16)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -9.098 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24576654)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 95.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 93.36 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 71.76 Tm [(364.)-6.7 ( K)2 (l)2.6 (ei)2.6 (n H)2.6 (es)-2 (s)-2 (el)2.7 (i)2.6 (nk)-2 ( E)2 (N)2.6 (,)4.3 ( S)2 (t)-6.6 (eenv)8.9 (oor)-5.9 (den D)13.5 (,)-6.6 ( K)2 (api)2.6 (t)-6.6 (ei)13.5 (j)-8.3 (n E)12.8 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( )11.3 (T)-10.6 (her)-6 (apy)8.9 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.152 Td [(endoc)-2 (r)-5.9 (i)2.6 (ne di)2.6 (s)-2 (eas)-2 (e:)4.3 ( r)-6 (e)10.5 (s)-2 (p)10.5 (ons)]TJ 12.185 0 Td [(e and )11.3 (t)-6.6 (ox)8.9 (i)2.6 (c)-2 (i)2.6 (t)-6.6 (y)8.9 ( of)-6.6 ( s)8.9 (m)-6 (al)2.6 (l)]TJ 0 Tc 0 Tw 9.522 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(m)-6 (ol)2.6 (ec)-2 (ul)2.6 (e t)-6.6 (y)8.8 (r)-5.9 (os)-2 (i)2.7 (ne )]TJ -22.043 -1.141 Td [(k)-12.9 (i)2.6 (nas)-1.9 (e)10.5 ( i)2.6 (nhi)2.6 (bi)2.7 (t)-6.6 (or)-6 (s)-1.9 ( i)2.6 (n pa)10.5 (t)-6.6 (i)2.6 (e)10.5 (nt)-6.7 (s)-2 ( )0.5 (w)13.4 (i)2.6 (t)-6.6 (h t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2.1 (a)10.6 (r)-6 (c)-2 (i)2.6 (nom)5 (a:)-6.6 ( a)10.5 ( s)-2 (y)8.9 (s)-2 (t)-6.6 (em)-5.9 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (r)-6 (ev)8.8 (i)2.6 (e)-11.2 (w)13.5 ( )]TJ 34.554 42.348 Td [(and m)-6 (e)10.5 (t)-6.6 (a)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 4.5 0 Td [(anal)2.6 (y)8.8 (s)-2 (i)2.7 (s)-2.1 (.)-6.6 ( E)2 (ur)4.9 ( J)8.8 ( E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( 2015;)-6.6 (1)10.5 (72:)-6.6 (R)2.7 (2)10.5 (15)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 18.88 0 Td [(225.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -23.38 -1.152 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.)]TJ -0.002 Tc 0.002 Tw [(nc)-2 (bi)2.7 (.)-6.6 (nl)2.6 (m)-6 (.)-6.5 (ni)2.6 (h.)4.2 (gov)8.9 (/)-6.6 (pubm)-6 (ed/)-6.6 (25572389)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 499.2 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 477.6 Tm [(365.)-6.7 ( A)2 (bdel)]TJ 0 Tc 0 Tw 4.772 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(R)2.6 (ah)10.5 (m)-6 (an )11.3 (O)-6.6 (,)4.3 ( F)11.1 (ouad M)15.8 (.)-6.6 ( R)2.6 (i)2.6 (s)-2 (k)-2 ( o)10.6 (f)-6.6 ( c)-2 (ar)-6 (di)2.6 (ov)8.8 (as)-2 (c)-2 (ul)2.6 (ar)-5.9 ( )11.2 (t)-6.6 (ox)8.9 (i)2.6 (c)-2 (i)2.6 (t)-6.6 (i)2.6 (es)-2 ( i)2.6 (n )]TJ -5.109 -1.141 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h s)-2 (ol)2.6 (i)2.6 (d t)-6.7 (u)10.6 (m)-6 (o)10.6 (r)4.9 (s)-2 ( t)4.3 (r)-5.9 (eat)-6.6 (ed)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h s)-2 (uni)2.6 (t)-6.6 (i)2.6 (ni)2.6 (b,)-6.6 ( a)10.5 (x)8.9 (i)2.6 (t)-6.6 (i)2.6 (ni)2.5 (b,)-6.6 ( c)-2 (edi)2.6 (r)-5.9 (ani)2.6 (b or)-6 ( )]TJ 0 -1.152 Td [(r)-6 (e)10.6 (g)-11.3 (or)-5.9 (a)10.5 (f)-6.6 (eni)2.6 (b:)-6.6 ( an)10.5 ( updat)-6.6 (ed)10.6 ( )11.2 (s)-2 (y)8.9 (s)-2 (t)-6.6 (em)-6 (at)-6.6 (i)2.6 (c)8.8 ( r)-5.9 (ev)8.9 (i)2.6 (ew)13.4 ( and c)-2 (om)-5.9 (par)-6 (a)10.6 (t)-6.6 (i)2.6 (v)8.8 (e m)-6 (et)-6.6 (a)]TJ 0 Tc 0 Tw 28.859 0 Td (-)Tj -0.005 Tc 0.01 Tw -28.859 -1.141 Td [(a)-3.3 (n)-3.4 (a)-3.3 (ly)5.9 (s)-5 (is)-5 (.)-9.6 ( Cr)-9 (it)-9.6 ( Re)-3.4 (v)]TJ 0 Tc 0 Tw 7.75 0 Td ( )Tj -0.002 Tc -0.004 Tw 0.283 0 Td [(O)-6.6 (nc)-2 (ol)2.6 ( H)2.6 (em)-5.9 (at)-6.6 (ol)2.6 ( )-10.6 (2014)10.6 (;)-6.6 (92:)-6.6 (194)]TJ 0 Tc 0 Tw 12.413 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(20)10.5 (7.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -20.783 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (25028151)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 426.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 424.92 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 403.32 Tm [(366.)-6.7 ( A)2 (bdel)]TJ 0 Tc 0 Tw 4.772 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(R)2.6 (ah)10.5 (m)-6 (an )11.3 (O)-6.6 (,)4.3 ( F)11.1 (ouad M)15.8 (.)-6.6 ( R)2.6 (i)2.6 (s)-2 (k)-2 ( o)10.6 (f)-6.6 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d d)10.5 (y)8.9 (s)-2 (f)-17.5 (unc)8.9 (t)-6.6 (i)2.6 (on i)2.6 (n pa)10.6 (t)-6.7 (i)2.7 (ent)-6.6 (s)-2 ( )]TJ -5.109 -1.141 Td [(w)2.6 (i)2.6 (t)-6.6 (h s)-2 (ol)2.6 (i)2.6 (d t)-6.6 (u)10.5 (m)-6 (or)-6 (s)8.9 ( t)4.3 (r)-6 (eat)-6.6 (ed)10.5 ( )11.3 (w)2.6 (i)2.6 (t)-6.6 (h V)2 (E)1.9 (G)-6.6 (F )11.3 (r)-6 (ec)-2 (ep)10.6 (t)-6.6 (or)4.9 ( t)-6.6 (y)8.9 (r)-6 (o)10.6 (s)-2 (i)2.6 (ne )11.2 (k)-12.8 (i)2.6 (nas)-2 (e i)2.6 (nhi)2.7 (bi)2.6 (t)-6.6 (or)-6 (s)8.9 (:)-6.6 ( a)10.5 ( )]TJ 0 -1.152 Td [(c)-2 (r)-6 (i)2.7 (t)-6.7 (i)2.7 (c)-2 (al)2.6 ( l)2.6 (i)2.6 (t)-6.6 (er)-6 (a)10.6 (t)-6.7 (ur)-6 (e)10.6 ( r)-6 (ev)8.8 (i)2.6 (ew)13.5 ( a)-11.3 (nd m)-5.9 (e)10.5 (t)-6.6 (a anal)2.6 (y)8.9 (s)-2 (i)2.6 (s)-2 (.)-6.6 ( E)2 (x)8.8 (per)-5.9 (t)4.2 ( R)2.7 (ev)8.9 ( A)1.9 (nt)-6.6 (i)2.6 (c)-2 (anc)-2 (er)-5.9 ( )11.3 (T)-10.6 (he)10.6 (r)-6 ( )]TJ 0.002 Tw 0 -1.141 Td [(2014;)-6.6 (14:)-6.6 (1063)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1073.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24927771)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 350.76 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 329.16 Tm [(367.)-6.7 ( C)2.7 (abani)2.6 (l)2.6 (l)2.6 (as)-2 ( )0.5 (M)15.7 (E)2 (,)-6.6 ( H)2.6 (u M)15.8 (I)-6.6 (,)-6.6 ( D)2.6 (ur)-6 (and J)-2 (B)12.8 (,)-6.6 ( B)1.9 (us)-2 (ai)2.7 (dy)8.9 ( )11.3 (N)2.6 (L.)-6.6 ( C)2.6 (hal)2.6 (l)2.6 (eng)-11.2 (es)8.8 ( )]TJ -0.004 Tw 0 -1.152 Td [(as)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (ed )-10.6 (w)13.5 (i)2.6 (t)-6.6 (h )-10.6 (t)-6.6 (y)8.8 (r)-5.9 (os)-2 (i)2.6 (ne k)-12.8 (i)2.6 (nas)-2 (e)10.5 ( )-10.6 (i)2.6 (nhi)2.6 (bi)2.6 (t)-6.6 (or)-5.9 ( t)-6.7 (her)-5.9 (apy)8.9 ( f)-6.6 (or)-6 ( m)-6 (et)-6.6 (as)8.9 (t)-6.6 (at)-6.6 (i)2.6 (c)8.9 ( )-10.6 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0.007 Tw 0 -1.141 Td [(c)-2 (anc)-2 (er)-6 (.)4.3 ( J)8.8 ( )11.3 (T)-10.6 (hy)8.9 (r)-6 (oi)2.7 (d R)2.6 (es)-2 ( )]TJ [(20)10.6 (11;)-6.7 (2011:)-6.6 (985780)10.6 (.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.5 (e at)-6.7 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 0 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22007339)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 291.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 289.08 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 267.48 Tm [(368.)-6.7 ( K)2 (r)-6 (a)10.6 (j)-8.3 (ew)13.5 (s)-2 (k)-12.9 (a)10.5 ( J)-2 (,)4.3 ( K)1.9 (u)10.5 (k)-12.8 (ul)13.5 (s)-2 (k)-12.9 (a)10.6 ( A)2 (,)4.3 ( J)-2 (ar)-5.9 (z)8.8 (ab B)12.9 (.)-6.6 ( D)2.6 (r)-6 (u)10.5 (g s)-2 (a)10.5 (f)-6.6 (et)-6.6 (y)8.9 ( ev)8.8 (al)2.6 (uat)-6.6 (i)2.6 (on o)10.5 (f)-17.4 ( )]TJ 0 -1.141 Td [(l)2.6 (env)8.9 (at)-6.6 (i)2.7 (ni)2.6 (b f)-17.5 (or)5 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (an)10.5 (c)-2 (er)-6 (.)4.3 ( E)2 (x)8.9 (per)-6 (t)-6.6 ( )11.3 (O)-6.6 (pi)2.6 (n D)2.6 (r)-5.9 (u)10.5 (g S)12.9 (a)10.5 (f)-17.5 ( 2)]TJ 0.002 Tw [(015)10.5 (;)-6.6 (14:)-6.6 (1935)]TJ 0 Tc 0 Tw 28.587 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(1943.)4.3 ( )]TJ 0.007 Tw -28.924 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)13.5 (w)2.6 (w)-8.3 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)4.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-6 (e)10.5 (d/)-6.6 (26484847)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 702.36 242.16 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 240.12 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 218.52 Tm [(369.)-6.7 ( S)2 (i)2.6 (der)-5.9 (as)8.9 ( K)1.9 (,)4.3 ( M)15.8 (enef)-17.4 (ee)10.6 ( M)15.8 (E)2 (,)-6.6 ( B)1.9 (ur)-6 (t)-6.6 (on)10.5 ( J)-2 (K)2 (,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( P)12.8 (r)4.9 (o)10.5 (f)-17.4 (ound hai)2.6 (r)4.9 ( and )11.2 (s)8.9 (k)-12.9 (i)2.6 (n )]TJ 0 -1.141 Td [(hy)8.8 (popi)2.6 (g)-11.2 (m)-6 (ent)-6.6 (a)10.5 (t)-6.6 (i)2.7 (on )0.5 (i)2.6 (n an)10.5 ( )11.2 (A)2 (f)-6.6 (r)-5.9 (i)2.5 (c)-2 (an A)12.8 (m)-6 (er)-6 (i)2.6 (c)-2 (an)10.5 ( w)13.5 (om)-5.9 (an t)4.2 (r)]TJ 22.543 0 Td [(eat)-6.6 (ed)10.6 ( w)13.4 (i)2.7 (t)-6.7 (h t)-6.6 (he )11.3 (m)-6 (ul)2.6 (t)-6.6 (i)]TJ 0 Tc 0 Tw 8.587 0 Td (-)Tj -0.002 Tc 0.007 Tw -31.13 -1.141 Td [(t)-6.6 (ar)5 (g)-11.3 (e)10.6 (t)-6.6 (ed )11.2 (t)-6.6 (y)8.9 (r)-6 (os)-2 (i)2.6 (ne )11.3 (k)-12.9 (i)2.6 (nas)-2 (e i)13.5 (nhi)2.6 (bi)2.6 (t)-6.6 (or)-6 ( paz)8.9 (opani)2.6 (b.)-6.6 ( J)8.8 ( C)2.6 (l)2.6 (i)2.7 (n O)-6.6 (nc)-1.9 (ol)13.5 ( 2010;)-6.6 (28)10.6 (:)-6.7 (e312)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 0 -1.152 Td [(313.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.2 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.7 (h.)-6.6 (g)-11.2 (ov)8.9 (/)-6.6 (pu)10.5 (bm)-5.9 (ed/)-6.6 (20516434)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 721.2 180.6 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 492.6 178.56 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 156.96 Tm [(370.)-6.7 ( M)15.8 (or)-6 (eno M)15.8 (A)1.9 (,)-6.6 ( A)2 (g)-11.2 (a)10.5 (r)-6 (w)13.5 (al)2.6 ( G)-6.7 (,)4.3 ( de )11.3 (Luna R)2.6 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( P)2 (r)4.9 (eoper)-6 (at)-6.6 (i)2.6 (v)8.8 (e l)2.6 (at)-6.6 (er)-5.9 (al)2.6 ( nec)8.9 (k)-2 ( )]TJ 0 -1.141 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2 (ono)10.5 (g)-11.2 (r)-6 (aphy)8.8 ( as)8.9 ( a l)2.6 (on)10.5 (g)]TJ 0 Tc 0 Tw 11.478 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(t)-6.6 (e)10.5 (r)-5.9 (m)4.9 ( out)-6.6 (c)-2 (o)10.5 (m)-6 (e)10.6 ( pr)-5.9 (edi)2.6 (c)-2 (t)-6.6 (o)10.5 (r)-6 ( i)2.6 (n papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ -11.804 -1.152 Td [(c)-2 (anc)-2 (er)-6 (.)4.3 ( A)1.9 (r)-5.9 (c)-2 (h)10.5 ( )11.3 (O)-6.6 (t)-6.7 (ol)2.6 (ar)-6 (y)8.9 (ngol)2.6 ( H)2.6 (ead N)2.6 (ec)8.8 (k)-2 ( S)2 (ur)5 (g)-11.3 ( 20)10.5 (11;)-6.6 (1)10.5 (37:)-6.6 (157)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 25.272 0 Td [(162)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -25.272 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21339402)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 119.04 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 117 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 95.4 Tm [(371.)-6.7 ( K)2 (ouv)8.9 (ar)-5.9 (a)10.5 (k)-12.9 (i)2.7 ( M)15.8 (A)2 (,)-6.6 ( S)1.9 (hapi)2.6 (r)-5.9 (o S)2 (E)1.9 (,)-6.6 ( Fo)10.5 (r)-5.9 (na)10.6 (g)-11.3 (e)10.6 ( B)1.9 (D)2.6 (,)-6.6 ( e)10.5 (t)-6.6 ( )11.3 (al)2.6 (.)-6.6 ( R)2.7 (ol)2.6 (e o)10.5 (f)-6.6 ( pr)-5.9 (eope)10.6 (r)-6 (at)-6.6 (i)2.7 (v)8.8 (e )]TJ 0 -1.152 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2 (ono)10.5 (g)-11.2 (r)-6 (aphy)8.8 ( i)2.6 (n )11.3 (t)-6.6 (he )11.2 (s)8.9 (ur)4.9 (g)-11.3 (i)2.7 (c)-2 (al)2.6 ( m)-5.9 (ana)10.5 (g)-11.2 (e)10.5 (m)-5.9 (ent)4.3 ( o)10.5 (f)-6.6 ( p)10.5 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.141 Td [(c)-2 (anc)-2 (er)-6 (.)4.3 ( S)1.9 (ur)4.9 (g)-11.2 (e)10.5 (r)-6 (y)8.9 ( 2003;)-6.6 (13)10.5 (4:)-6.6 (946)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.75 0 Td [(954)10.5 (;)-6.6 ( di)2.6 (s)-2 (c)-2 (us)-2 (s)-2 (i)2.7 (on)10.5 ( 95)10.5 (4)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.13 0 Td [(945.)4.2 ( A)]TJ 2.88 0 Td [(v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -25.761 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (14668727)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 57.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 55.44 228.72 0.84 re f EMC endstream endobj 1066 0 obj 28102 endobj %% Contents for page 125 %% Original object ID: 251 0 1067 0 obj << /Length 1068 0 R >> stream Q q BT /Xi123 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1068 0 obj 246 endobj %% Original object ID: 11863 0 1069 0 obj [ 3019 0 R 3020 0 R 3021 0 R 3022 0 R 3023 0 R 3024 0 R 3025 0 R 3026 0 R 3027 0 R 3028 0 R 3029 0 R 3030 0 R 3031 0 R 3032 0 R ] endobj %% Contents for page 126 %% Original object ID: 252 0 1070 0 obj << /Length 1071 0 R >> stream q endstream endobj 1071 0 obj 2 endobj %% Contents for page 126 %% Original object ID: 11864 0 1072 0 obj << /Length 1073 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (63)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(372.)-6.7 ( S)2 (ol)2.6 (or)-5.9 (z)8.8 (ano C)2.6 (C)2.6 (,)-6.6 ( C)2.6 (a)10.5 (r)4.9 (nei)2.6 (r)-6 (o D)2.6 (M)15.7 (,)-6.5 ( R)2.7 (am)-5.9 (i)2.6 (r)-6 (ez)8.8 ( M)15.8 (,)-6.6 ( et)-6.6 ( )11.3 (al)2.6 (.)-6.6 ( S)1.9 (ur)4.9 (g)-11.2 (eon)]TJ 0 Tc 0 Tw 26.75 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(per)4.9 (f)-6.6 (or)4.9 (m)-6 (ed )]TJ 0.007 Tw -27.087 -1.152 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2 (ound i)2.6 (n)10.5 ( t)-6.6 (he)10.6 ( m)-6 (ana)10.5 (gem)-5.9 (ent)4.3 ( o)10.6 (f)-6.6 ( t)-6.5 (hy)8.9 (r)-6 (oi)2.6 (d )11.3 (m)-6 (al)2.6 (i)2.6 (g)-11.2 (na)10.6 (nc)-2 (y)8.9 (.)-6.6 ( A)2 (m)-6 ( S)2 (u)10.5 (r)4.9 (g)-11.2 ( )]TJ 0.002 Tw 0 -1.141 Td [(2004;)-6.6 (70:)-6.6 (57)]TJ 0 Tc 0 Tw (6)Tj 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(580;)4.2 ( di)2.6 (s)-2 (c)-2 (us)8.9 (s)-2 (i)2.6 (on 580)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.141 0 Td [(572.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e )-10.5 (at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -15.022 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (15279178)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 473.88 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 452.28 Tm [(373.)-6.7 ( S)2 (t)4.3 (ul)2.6 (ak)-2 ( J)-2 (M)15.8 (,)-6.7 ( )0.5 (G)4.2 (r)-5.9 (ant)4.2 ( C)13.5 (S)2 (,)-6.7 ( Far)-6 (l)2.7 (ey)8.9 ( D)2.6 (R)2.6 (,)-6.6 ( e)10.5 (t)-6.6 ( al)13.4 (.)-6.6 ( V)2 (al)2.6 (u)10.6 (e o)10.5 (f)-6.6 ( pr)-6 (eope)10.5 (r)-5.9 (at)-6.6 (i)2.6 (v)8.9 (e )]TJ 0 -1.141 Td [(ul)2.6 (t)-6.6 (r)-6 (as)-2 (ono)10.5 (g)-11.2 (r)-6 (aphy)8.8 ( i)2.7 (n )11.3 (t)-6.6 (he )11.2 (s)8.9 (ur)4.9 (g)-11.3 (i)2.7 (c)-2 (al)2.6 ( m)-5.9 (ana)10.5 (g)-11.2 (e)10.5 (m)-5.9 (ent)4.2 ( o)]TJ 20.489 0 Td [(f)-6.6 ( i)13.5 (ni)2.6 (t)-6.6 (i)2.6 (al)2.6 ( and r)-5.9 (eope)10.6 (r)-6 (at)-6.6 (i)2.6 (v)8.9 (e )]TJ -20.489 -1.152 Td [(papi)2.6 (l)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)-6 (.)-6.6 ( )11.3 (A)2 (r)-6 (c)-2 (h )0.5 (S)1.9 (ur)5 (g 2006)10.5 (;)-6.6 (141:)-6.7 (489)]TJ 0 Tc 0 Tw 21.609 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(494;)4.2 ( di)2.6 (s)-2 (c)-2 (us)-2 (s)-2 (i)2.7 (on 494)]TJ 0 Tc 0 Tw 8.804 0 Td (-)Tj -0.002 Tc 0.007 Tw -30.75 -1.141 Td [(486.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.2 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)-6.6 (g)-11.2 (ov)8.9 (/)-6.6 (pu)10.5 (bm)-5.9 (ed/)-6.6 (16702521)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 339.72 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 111.12 412.32 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 390.72 Tm [(374.)-6.7 ( )11.3 (O)-6.6 (')-6.6 (C)2.6 (onnel)2.6 (l)2.6 ( K)2 (,)4.2 ( Y)2 (en )11.2 (TW)-25.3 (,)15.1 ( )11.3 (Q)-6.7 (ui)2.6 (r)-6 (oz)8.9 ( F)11.2 (,)-6.7 ( e)]TJ 17.141 0 Td [(t)-6.6 ( al)2.7 (.)4.2 ( )11.3 (T)-10.6 (he u)10.5 (t)-6.6 (i)2.6 (l)2.6 (i)2.7 (t)-6.7 (y)8.9 ( of)-6.6 ( r)-6 (ou)10.5 (t)-6.6 (i)2.6 (ne )]TJ -17.141 -1.152 Td [(pr)-6 (eoper)-5.9 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e c)-2 (er)-5.9 (v)8.9 (i)2.6 (c)-2 (al)2.7 ( ul)2.6 (t)-6.6 (r)-6 (as)-2 (onogr)-6 (aphy)8.9 ( i)2.6 (n pat)-6.6 (i)2.6 (ent)4.2 (s)-2 ( )11.3 (under)4.9 (g)-11.2 (oi)2.7 (ng )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( )11.3 (f)-17.5 (o)10.5 (r)-6 ( di)13.5 (f)-6.6 (f)-6.6 (e)10.5 (r)-6 (e)10.6 (nt)-6.6 (i)2.6 (at)-6.7 (ed )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-5.9 (.)4.2 ( S)2 (ur)5 (g)-11.3 (er)-6 (y)8.9 ( 2013;)-6.6 (154)10.5 (:)-6.6 (697)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 30.978 0 Td [(70)10.5 (1;)-6.6 ( )]TJ 0.007 Tw -30.978 -1.141 Td [(di)2.6 (s)-2 (c)-2 (us)-2 (s)-2 (i)2.6 (on 701)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 6.935 0 Td [(693)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.935 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24011674)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 340.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 338.04 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 316.44 Tm [(375.)-6.7 ( S)2 (i)2.6 (nc)-2 (l)2.6 (ai)2.7 (r)-6 ( C)2.6 (F,)4.3 ( D)2.6 (u)10.5 (k)-12.9 (e )11.2 (W)-25.3 (S)12.8 (,)4.2 ( B)2 (a)10.5 (r)-5.9 (bu A)1.9 (M)15.8 (,)-6.6 ( R)2.6 (andol)2.6 (ph G)26 (W)-36.2 (.)4.2 ( )11.3 (Lar)-5.9 (y)8.8 (ng)-11.2 (eal)13.4 ( E)2 (x)8.9 (am)-5.9 ( )]TJ 0 -1.141 Td [(I)-6.6 (ndi)2.6 (c)-2 (at)-6.6 (i)2.6 (ons)-2 ( and)10.5 ( )11.3 (T)-10.6 (ec)-2 (hni)13.4 (q)-11.2 (u)10.5 (es)-2 (.)-6.6 ( )11.3 (I)-6.7 (n:)4.3 ( R)2.6 (andol)2.6 (ph )11.3 (G)15.1 (W)-25.4 (,)4.3 ( ed)10.5 (.)-6.6 ( )11.3 (T)-10.6 (he)10.5 ( R)2.6 (ec)-2 (ur)4.9 (r)-5.9 (ent)4.3 ( and )]TJ 0 -1.152 Td [(S)2 (uper)-5.9 (i)2.6 (or)-5.9 ( La)10.6 (r)-6 (y)8.9 (ng)-11.2 (eal)2.6 ( N)2.6 (er)-6 (v)8.9 (es)-2 (.)-6.6 ( S)2 (w)13.5 (i)2.6 (t)-6.6 (z)8.8 (er)-6 (l)2.7 (and:)-6.6 ( S)2 (pr)-5.9 (i)2.6 (ng)-11.2 (e)10.5 (r)4.9 ( I)-6.6 (n)10.5 (t)-6.6 (er)-6 (na)10.5 (t)-6.6 (i)2.6 (onal)2.6 ( P)1.9 (ubl)2.7 (i)2.6 (s)-2 (hi)2.6 (ng)-11.2 (;)4.2 ( )]TJ 0 Tc 0 Tw 0 -1.141 Td (2)Tj -0.002 Tc 0.002 Tw 0.554 0 Td [(016:)-6.7 (17)]TJ 0 Tc 0 Tw (-)Tj -0.013 Tc 0.013 Tw 3.391 0 Td [(2)-11.3 (9.)]TJ 0 Tc 0 Tw 1.37 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -5.315 -2.141 Td [(376.)-6.7 ( C)2.7 (ar)4.9 (t)-6.6 (y)8.9 ( S)1.9 (E)2 (,)-6.6 ( C)2.6 (oope)10.5 (r)-6 ( D)13.5 (S)2 (,)-6.7 ( )0.5 (D)2.6 (oher)4.9 (t)-6.6 (y)8.9 ( G)-6.6 (M)15.8 (,)-6.7 ( )0.5 (et)4.3 ( al)2.6 (.)4.3 ( C)2.6 (ons)-2 (ens)-2 (us)-2 ( s)8.8 (t)-6.6 (at)-6.6 (e)10.5 (m)-6 (en)10.5 (t)-6.6 ( on)10.6 ( )]TJ -0.004 Tw 0 -1.152 Td [(t)-6.6 (he t)-6.6 (er)4.9 (m)-5.9 (i)2.6 (nol)2.6 (og)-11.2 (y)8.9 ( )-10.6 (and c)-2 (l)2.6 (as)-2 (s)-2 (i)2.6 (f)-17.5 (i)2.6 (c)-2 (a)10.5 (t)-6.6 (i)2.6 (on )-10.6 (o)10.5 (f)-6.6 ( )-10.6 (c)-2 (en)10.6 (t)-6.7 (r)-5.9 (al)2.6 ( )-10.6 (ne)10.5 (c)8.9 (k)-12.9 ( di)2.6 (s)-2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (on f)-17.5 (o)10.5 (r)-5.9 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.141 Td [(c)-2 (anc)-2 (er)-6 (.)4.3 ( T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (2009;)-6.6 (19)10.5 (:)4.3 (1153)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.576 0 Td [(1158.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -13.576 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19860578)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 216.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 214.92 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 193.32 Tm [(377.)-6.7 ( C)2.7 (ar)-5.9 (on)10.5 ( N)2.6 (R)2.7 (,)4.2 ( )11.3 (T)-10.6 (an Y)2 (Y)1.9 (,)4.3 ( )11.2 (O)4.3 (g)-11.2 (i)2.6 (l)2.6 (v)8.9 (i)2.6 (e )0.5 (J)-2 (B)1.9 (,)-6.6 ( et)-6.7 ( al)13.5 (.)-6.6 ( S)1.9 (el)2.6 (ec)-2 (t)-6.6 (i)2.6 (v)8.9 (e m)-6 (odi)13.5 (f)-17.5 (i)2.6 (ed)10.5 ( r)-6 (adi)2.6 (c)-2 (al)2.6 ( nec)8.9 (k)-2 ( )]TJ 0 -1.152 Td [(di)2.6 (s)-2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (on )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( papi)2.6 (l)2.7 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.6 (h)10.6 (y)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)]TJ 0 Tc 0 Tw 16.402 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(i)2.6 (s)-2 ( l)2.6 (ev)8.8 (el)2.6 ( I)4.3 (,)-6.7 ( )11.3 (I)-6.6 (I)4.3 ( )11.2 (and V)1.9 ( di)2.6 (s)-2 (s)-2 (ec)8.8 (t)-6.6 (i)2.6 (on al)2.6 (w)13.5 (a)-11.2 (y)8.8 (s)-2 ( )]TJ -16.739 -1.141 Td [(nec)-2 (es)-2 (s)-2 (ar)-5.9 (y)8.8 (? )22.1 (W)-36.2 (o)10.5 (r)-6 (l)2.6 (d)10.6 ( J)8.8 ( S)2 (ur)4.9 (g 2006;)-6.6 (30)10.5 (:)-6.6 (833)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 17.293 0 Td [(840)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e a)]TJ -0.006 Tc 0.006 Tw [(t)-10.6 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw -17.293 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (16555024)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 155.28 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 153.24 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 131.64 Tm [(378.)-6.7 ( S)2 (t)4.3 (ac)8.9 (k)-12.9 ( B)2 (C)13.4 (,)-6.5 ( J)8.8 (r)-5.9 (.)4.2 (,)-6.6 ( Fe)10.5 (r)-5.9 (r)-6 (i)13.5 (s)-2 ( R)2.6 (L,)4.2 ( G)-6.6 (ol)2.6 (denber)5 (g D)2.6 (,)4.3 ( et)4.3 ( a)10.5 (l)2.6 (.)-6.6 ( A)2 (m)-6 (e)10.5 (r)-5.9 (i)2.6 (c)-2 (an )11.3 (T)-10.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.141 Td [(A)2 (s)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (i)2.6 (on c)-2 (ons)-2 (ens)-2 (us)8.8 ( r)4.9 (ev)8.9 (i)2.6 (e)-11.3 (w)13.5 ( and s)-2 (t)-6.6 (at)-6.6 (e)10.6 (m)-6 (ent)4.3 ( r)-6 (e)10.5 (gar)-5.9 (di)2.6 (ng t)-6.6 (he)10.5 ( anat)-6.7 (o)10.6 (m)-6 (y)8.9 (,)-6.6 ( )]TJ 0.002 Tw 0 -1.152 Td [(t)-6.6 (er)5 (m)-6 (i)2.6 (nol)2.6 (og)-11.2 (y)8.8 (,)-6.6 ( )]TJ 0.007 Tw 5.717 0 Td [(and)10.5 ( r)-5.9 (a)10.5 (t)-6.6 (i)2.6 (onal)2.6 (e )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( l)2.6 (at)-6.6 (e)10.5 (r)-5.9 (al)2.6 ( nec)8.8 (k)-2 ( di)2.6 (s)-2 (s)-2 (ec)8.8 (t)-6.6 (i)2.6 (on i)2.6 (n di)13.5 (f)-6.6 (f)-17.5 (e)10.6 (r)-6 (ent)-6.6 (i)2.6 (a)10.5 (t)-6.6 (ed )]TJ -5.717 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 (.)-6.7 ( )11.3 (T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d 2)10.6 (012;)-6.6 (22:)-6.6 (501)]TJ 0 Tc 0 Tw 15.957 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(508.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)-8.2 (e at)4.2 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -16.293 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22435914)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 81.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 79.08 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 57.48 Tm [(379.)-6.7 ( V)2 (i)2.6 (ol)2.6 (a D)2.6 (,)4.3 ( M)15.8 (at)-6.6 (er)-6 (az)8.8 (z)-2 (i)2.7 ( G)-6.6 (,)4.3 ( V)2 (al)2.6 (er)-6 (i)2.6 (o L)]TJ [(,)4.3 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( P)2 (r)-6 (oph)10.6 (y)8.8 (l)2.6 (ac)-2 (t)-6.6 (i)2.6 (c)-2 ( c)-2 (ent)-6.6 (r)-6 (al)2.6 ( )]TJ 0 -1.152 Td [(c)-2 (om)-6 (par)4.9 (t)-6.6 (m)-5.9 (e)10.5 (nt)4.3 ( l)2.6 (y)8.9 (m)-6 (ph nod)10.6 (e di)2.7 (s)-2 (s)-2 (ec)-2 (t)-6.6 (i)2.6 (on i)2.6 (n)10.5 ( )0.5 (papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.6 (:)-6.6 ( c)-2.1 (l)2.7 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( )]TJ 34.554 42.5 Td [(i)2.6 (m)-5.9 (pl)2.6 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (ons)-2 ( der)-6 (i)2.7 (v)8.8 (ed )11.3 (f)-17.5 (r)-6 (o)10.6 (m)4.9 ( t)-6.6 (he)10.6 ( )11.2 (f)-17.5 (i)2.7 (r)-6 (s)8.9 (t)-6.6 ( p)10.5 (r)-6 (os)-2 (pec)8.9 (t)-6.6 (i)2.6 (v)8.8 (e r)-6 (an)10.5 (dom)-5.9 (i)2.6 (z)8.8 (ed c)-2 (ont)-6.6 (r)-5.9 (ol)2.6 (l)2.7 (ed s)-2 (i)2.6 (n)10.5 (g)-11.2 (l)13.4 (e )]TJ 0 -1.152 Td [(i)2.6 (ns)-2 (t)-6.6 (i)2.6 (t)-6.6 (ut)-6.6 (i)2.6 (on s)8.9 (t)-6.6 (udy)8.8 (.)-6.6 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.7 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2015;)-6.6 (10)10.5 (0:)-6.6 (1316)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 25.217 0 Td [(1324)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e )]TJ 0 Tc 0 Tw -25.217 -1.141 Td (a)Tj -0.006 Tc 0.006 Tw 0.554 0 Td [(t)-10.6 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 0.837 0 Td [(ht)4.2 (t)-6.6 (ps)-2 (:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)4.2 (ni)2.6 (h.)-6.6 (g)-11.3 (ov)8.9 (/)-6.6 (pub)10.5 (m)-6 (ed/)-6.6 (255902)10.5 (15)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 654.48 488.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 420.36 486.6 234.12 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 465 Tm [(380.)-6.7 ( H)2.7 (ai)13.5 (g)-11.2 (h P)2 (I)4.2 (,)4.3 ( U)2.6 (r)-6 (bac)-2 (h)10.5 ( D)2.6 (R)2.6 (,)-6.6 ( R)2.6 (ot)-6.6 (s)8.8 (t)-6.6 (ei)2.6 (n LE)1.9 (.)4.3 ( E)1.9 (x)8.9 (t)-6.6 (ent)4.3 ( o)10.5 (f)-6.6 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (o)10.5 (m)-5.9 (y)8.8 ( )0.5 (i)2.6 (s)-2 ( not)4.2 ( a )]TJ 0 -1.152 Td [(m)-6 (aj)-8.3 (o)10.6 (r)-6 ( de)10.6 (t)-6.6 (er)4.9 (m)-5.9 (i)2.6 (nant)4.3 ( o)10.5 (f)-6.6 ( s)-2 (ur)4.9 (v)8.9 (i)-8.3 (v)8.9 (al)2.6 ( i)2.6 (n l)2.6 (o)-11.2 (w)]TJ 0 Tc 0 Tw 15.609 0 Td (-)Tj 0.337 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(or)-6 ( hi)2.6 (g)-11.3 (h)]TJ 0 Tc 0 Tw 3.054 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(r)-6 (i)2.7 (s)8.8 (k)-2 ( )11.3 (papi)2.7 (l)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (e)]TJ 0.004 Tc -0.004 Tw [(r.)-0.6 ( )]TJ -0.002 Tc 0.007 Tw -19.62 -1.141 Td [(A)2 (nn S)1.9 (ur)4.9 (g)-11.2 ( )11.2 (O)-6.6 (nc)-2 (ol)2.6 ( 2005)10.5 (;)-6.6 (12)10.5 (:)-6.6 (81)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 12.641 0 Td [(89)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -12.641 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (15827782)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 426.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 424.92 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 403.32 Tm [(381.)-6.7 ( D)2.7 (av)8.9 (i)2.6 (es)-1.9 ( L,)-6.6 ( )33 (W)-36.3 (e)10.6 (l)2.6 (c)-2 (h H)13.5 (G)-6.6 (.)4.3 ( )11.2 (T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 ( s)-2 (u)10.5 (r)-5.9 (v)8.8 (i)2.7 (v)-2 (al)2.6 ( i)2.6 (n t)-6.6 (he U)2.6 (ni)2.6 (t)-6.6 (ed)10.5 ( S)2 (t)-6.7 (a)10.6 (t)-6.6 (es)8.9 (:)-6.6 ( )]TJ 0 -1.141 Td [(obs)-2 (er)-6 (v)8.9 (at)-6.6 (i)2.6 (onal)2.6 ( dat)-6.6 (a )11.2 (f)-6.6 (r)-6 (o)10.6 (m)4.9 ( )11.3 (1973 t)-6.6 (o)10.5 ( 2)]TJ [(005.)4.3 ( A)1.9 (r)-5.9 (c)-2 (h)10.5 ( )11.2 (O)-6.6 (t)-6.6 (ol)2.6 (a)10.5 (r)-5.9 (y)8.8 (ng)-11.2 (ol)2.6 ( H)2.6 (ead N)2.6 (ec)8.9 (k)-2 ( S)2 (ur)4.9 (g )]TJ 0.002 Tw 0 -1.152 Td [(2010;)-6.6 (136:)-6.6 (440)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(444.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (20479371)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 365.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 363.36 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 341.76 Tm [(382.)-6.7 ( B)2 (i)2.6 (l)2.6 (i)2.6 (m)-5.9 (or)-5.9 (i)2.6 (a K)2 (Y)1.9 (,)4.3 ( B)2 (ent)4.2 (r)4.9 (em)-6 ( D)2.7 (J)8.8 (,)-6.6 ( K)2 (o)10.5 ( C)2.6 (Y)2 (,)-6.7 ( e)10.6 (t)-6.6 ( al)13.5 (.)-6.6 ( E)1.9 (x)8.9 (t)4.3 (ent)-6.6 ( o)10.5 (f)-6.6 ( s)-2 (u)10.5 (r)4.9 (g)-11.2 (er)-5.9 (y)8.9 ( a)10.5 (f)-6.6 (f)-6.6 (ec)8.9 (t)-6.6 (s)-2 ( )]TJ -0.011 Tc 0.016 Tw 0 -1.141 Td [(s)-11 (u)-9.3 (r)-15 (vi)-6.4 (va)-20.2 (l)-6.4 ( f)-26.5 (o)]TJ -0.002 Tc 0.007 Tw 4.489 0 Td [(r)-6 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)4.9 (oi)2.6 (d c)-2 (anc)-2.1 (er)4.9 (.)-6.6 ( A)2 (nn)10.5 ( S)2 (ur)4.9 (g)-11.3 ( 20)10.5 (07;)-6.6 (246:)-6.6 (375)]TJ 0 Tc 0 Tw 21.935 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(381;)4.2 ( )]TJ 0.007 Tw -26.761 -1.152 Td [(di)2.6 (s)-2 (c)-2 (us)-2 (s)-2 (i)2.6 (on 381)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 6.935 0 Td [(374)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.935 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (17717441)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 303.84 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 301.8 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 280.2 Tm [(383.)-6.7 ( K)2 (i)2.6 (er)-6 (nan)10.6 ( C)2.7 (M)15.7 (,)-6.6 ( P)2 (ar)-5.9 (i)2.6 (k)-12.9 (h)10.5 ( A)2 (A)2 (,)-6.7 ( P)2 (a)10.5 (r)4.9 (k)-12.8 (s)-2 ( )11.2 (LL,)4.3 ( S)2 (ol)2.6 (or)-6 (z)8.9 (ano C)2.6 (C)2.7 (.)-6.6 ( U)2.7 (s)-2 (e)10.5 ( o)10.5 (f)-6.6 ( r)-6 (ad)]TJ 0.002 Tw [(i)2.6 (oi)2.6 (odi)2.6 (ne )]TJ 0.007 Tw 0 -1.152 Td [(a)10.5 (f)-17.5 (t)-6.6 (e)10.6 (r)-6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d l)2.7 (obec)-2 (t)-6.6 (om)-6 (y)8.9 ( i)13.4 (n pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (i)2.7 (t)-6.7 (h di)13.4 (f)-6.6 (f)-17.5 (e)10.6 (r)-6 (ent)-6.6 (i)2.6 (a)10.6 (t)-6.7 (ed )11.3 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (:)-6.6 ( doe)10.5 (s)-2 ( )]TJ 0 -1.141 Td [(i)2.6 (t)-6.6 ( c)-2 (han)10.5 (g)-11.2 (e ou)10.5 (t)-6.6 (c)-2 (o)10.6 (m)-6 (es)-2 (?)10.5 ( J)-2 ( A)12.8 (m)-6 ( C)2.6 (ol)2.6 (l)2.6 ( S)2 (ur)4.9 (g 2015;)-6.6 (220)10.5 (:)-6.6 (61)10.5 (7)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 22.826 0 Td [(625.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.826 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (25667136)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 242.16 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 240.12 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 218.52 Tm [(384.)-6.7 ( B)2 (r)-6 (i)2.7 (e)10.5 (r)-6 (l)2.6 (ey)8.9 ( J)-2.1 (,)-6.5 ( )11.2 (T)-10.5 (s)-2.1 (an)10.5 (g R)2.6 (,)4.3 ( P)2 (anz)8.9 (ar)-5.9 (el)2.6 (l)2.7 (a T)-10.6 (,)4.3 ( B)2 (ana N)13.5 (.)-6.6 ( P)12.8 (r)-6 (o)10.6 (g)-11.2 (nos)-2 (t)-6.6 (i)2.6 (c)8.8 ( )11.3 (f)-17.5 (ac)8.8 (t)-6.6 (or)-6 (s)8.9 ( and)10.5 ( t)-6.6 (he)10.5 ( )]TJ 0 -1.141 Td [(e)10.5 (f)-6.6 (f)-17.5 (ec)8.9 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.2 (t)-6.6 (r)-5.9 (ea)10.5 (t)4.3 (m)-5.9 (ent)4.2 ( w)13.5 (i)2.6 (t)-6.6 (h )0.5 (r)4.9 (adi)2.6 (oac)-2 (t)-6.6 (i)2.6 (v)8.9 (e i)2.6 (odi)2.6 (ne and ex)8.9 (t)-6.6 (er)-6 (nal)2.6 ( beam)4.9 ( r)-6 (adi)2.6 (a)10.6 (t)-6.6 (i)2.6 (on on )]TJ 0 -1.141 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h di)13.5 (f)-6.6 (f)-6.6 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (e)10.5 (d )0.5 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (e)10.6 (r)-6 ( s)-2 (ee)10.6 (n a)10.5 (t)-6.6 ( )11.3 (a s)-2 (i)2.7 (ng)-11.2 (l)2.6 (e)10.5 ( i)2.6 (ns)-2 (t)-6.6 (i)2.6 (t)-6.6 (u)10.5 (t)-6.6 (i)2.6 (on ov)8.8 (er)-6 ( )]TJ 0 -1.152 Td [(40 y)8.9 (ear)-6 (s)-2 (.)-6.6 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)8.9 (r)-6 (i)2.6 (nol)2.7 ( )]TJ [(\()4.9 (O)-6.6 (x)8.8 (f)-6.6 (\))-5.9 ( 2005)10.5 (;)-6.6 (63)10.5 (:)-6.6 (418)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 19.728 0 Td [(427)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -19.728 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (16181234)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 168 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 165.96 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 144.36 Tm [(385.)-6.7 ( C)2.7 (how)13.4 ( S)2 (M)15.8 (,)-6.6 ( Y)1.9 (au S)2 (,)-6.6 ( K)12.8 (w)13.5 (an C)2.6 (K)2 (,)-6.7 ( et)-6.6 ( al)2.6 (.)4.3 ( Loc)-2 (al)2.6 ( and)10.5 ( )11.3 (r)-6 (e)10.5 (g)-11.2 (i)2.6 (onal)2.6 ( c)-2 (ont)4.3 (r)-6 (ol)2.6 ( i)2.6 (n )]TJ 0 -1.152 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-6 (a:)4.3 ( s)-2 (pec)]TJ 20.337 0 Td [(i)13.5 (f)-17.5 (i)2.6 (c)8.9 ( i)2.6 (ndi)2.6 (c)-2 (at)-6.7 (i)2.7 (ons)-2 ( o)10.5 (f)-6.6 ( ex)8.9 (t)-6.6 (er)-5.9 (nal)2.6 ( )]TJ -20.337 -1.141 Td [(r)-6 (adi)2.7 (ot)-6.6 (her)-5.9 (apy)8.8 ( and )11.3 (r)-6 (adi)2.6 (oac)8.9 (t)-6.6 (i)2.6 (v)8.9 (e i)2.6 (odi)2.6 (ne ac)-2 (c)-2 (or)-5.9 (di)2.6 (ng t)-6.6 (o)10.5 ( )11.3 (T and N)2.6 ( )11.3 (c)-2 (at)-6.6 (e)10.5 (g)-11.2 (o)10.6 (r)-6 (i)2.6 (es)-2 ( i)2.6 (n )]TJ 0 -1.152 Td [(A)2 (J)-2 (C)2.6 (C)2.6 ( 6t)-6.6 (h edi)2.6 (t)-6.6 (i)2.6 (on)10.6 (.)-6.6 ( E)2 (ndoc)8.8 (r)-5.9 ( R)2.6 (el)2.7 (at)4.3 ( C)2.6 (anc)-2 (er)5 ( 2006;)-6.7 (13)10.5 (:)4.3 (1159)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 23.989 0 Td [(1172.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -23.989 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (17158761)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 93.72 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 91.68 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 70.08 Tm [(386.)-6.7 ( Lee)10.6 ( N)2.6 (,)4.2 ( )11.3 (T)-10.5 (ut)4.3 (t)-6.6 (l)2.6 (e M)15.8 (.)-6.6 ( Th)10.5 (e r)-6 (ol)2.6 (e o)10.6 (f)-6.7 ( ex)8.9 (t)-6.6 (er)-6 (n)10.6 (al)2.6 ( beam)4.9 ( r)4.9 (adi)2.6 (ot)-6.6 (her)-6 (apy)8.9 ( i)2.6 (n t)-6.7 (he)10.5 ( )]TJ 0 -1.141 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-1.9 (anc)-2 (e)10.5 (r)-6 (.)4.3 ( E)1.9 (ndoc)-2 (r)4.9 ( R)2.6 (el)2.6 (at)-6.6 ( C)2.6 (anc)-2 (e)10.6 (r)-6 ( 2006)10.5 (;)-6.6 (13:)-6.6 (971)]TJ 0 Tc 0 Tw 31.467 0 Td (-)Tj -0.002 Tc 0.007 Tw -31.467 -1.152 Td [(977.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.7 (abl)2.6 (e at)-6.6 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.2 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.7 (h.)-6.6 (g)-11.2 (ov)8.9 (/)-6.6 (pu)10.5 (bm)-5.9 (ed/)-6.6 (17158749)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 721.2 44.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 492.6 42.72 228.6 0.84 re f EMC endstream endobj 1073 0 obj 27805 endobj %% Contents for page 126 %% Original object ID: 253 0 1074 0 obj << /Length 1075 0 R >> stream Q q BT /Xi124 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1075 0 obj 246 endobj %% Original object ID: 11879 0 1076 0 obj [ 3033 0 R 3034 0 R 3035 0 R 3036 0 R 3037 0 R 3038 0 R 3039 0 R 3040 0 R 3041 0 R 3042 0 R 3043 0 R 3044 0 R 3045 0 R 3046 0 R 3047 0 R 3048 0 R ] endobj %% Contents for page 127 %% Original object ID: 254 0 1077 0 obj << /Length 1078 0 R >> stream q endstream endobj 1078 0 obj 2 endobj %% Contents for page 127 %% Original object ID: 11880 0 1079 0 obj << /Length 1080 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (64)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(387.)-6.7 ( B)2 (r)-6 (i)2.7 (e)10.5 (r)-6 (l)2.6 (ey)8.9 ( J)-2 (D)2.7 (,)-6.6 ( )11.2 (T)-10.5 (s)-2 (an)10.5 (g )11.3 (R)24.3 (W)-36.3 (.)4.3 ( E)2 (x)8.8 (t)-6.6 (er)-6 (nal)13.5 ( beam)4.9 ( r)-6 (adi)13.5 (at)-6.6 (i)2.6 (on t)-6.6 (he)10.5 (r)-5.9 (apy)8.9 ( )11.2 (f)-17.5 (o)10.6 (r)-6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (anc)-2 (er)-6 (.)4.3 ( E)1.9 (ndoc)-2 (r)-6 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab C)2.6 (l)2.6 (i)2.6 (n N)2.6 (or)-5.9 (t)-6.6 (h)10.5 ( A)1.9 (m)5 ( 2008;)-6.7 (37)10.5 (:)-6.6 (497)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 23.946 0 Td [(509)10.5 (,)-6.6 ( x)8.9 (i)2.6 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -23.946 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (18502339)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 488.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 486.6 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 465 Tm [(388.)-6.7 ( P)2 (ac)-2 (i)2.6 (ni)2.6 ( F,)4.3 ( A)12.8 (g)-11.2 (at)-6.7 (e)10.6 ( L)10.5 (,)-6.6 ( E)12.8 (l)2.6 (i)2.6 (s)-2 (ei)2.6 ( R)2.6 (,)-6.6 ( et)4.3 ( al)2.6 (.)-6.7 ( )11.3 (O)-6.6 (ut)4.2 (c)-2 (om)-6 (e)10.5 ( o)10.6 (f)-6.6 ( di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (at)-6.6 (ed)10.5 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (anc)-2 (er)-6 ( w)13.5 (i)2.6 (t)-6.6 (h det)-6.6 (e)10.6 (c)-2 (t)-6.7 (abl)2.6 (e )11.3 (s)8.9 (er)-6 (um)4.9 ( )11.3 (Tg)-11.2 ( and)10.5 ( ne)10.6 (g)-11.2 (at)-6.6 (i)2.6 (v)8.9 (e di)2.6 (ag)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (\()-6 (131\))4.9 (I)-6.6 ( w)13.5 (hol)2.6 (e )]TJ 0 -1.141 Td [(body)8.8 ( s)-2 (c)-2 (an:)-6.6 ( c)-2 (o)10.6 (m)-6 (par)-6 (i)2.7 (s)-2 (on)10.5 ( o)10.5 (f)-6.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( t)4.3 (r)-6 (eat)-6.6 (ed)10.6 ( w)13.4 (i)2.6 (t)-6.6 (h hi)2.7 (gh \()-6 (131)10.5 (\))-5.9 (I)4.2 ( ac)-2 (t)-6.6 (i)2.6 (v)8.9 (i)]TJ 28.13 0 Td [(t)-6.6 (i)2.6 (es)-2 ( v)8.8 (er)-6 (s)-2 (us)-2 ( )]TJ -28.13 -1.152 Td [(unt)-6.6 (r)-6 (ea)10.5 (t)-6.6 (ed pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 (.)-6.7 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2001;)4.3 (86:)-6.6 (4092)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 25.772 0 Td [(4097)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e )]TJ -0.006 Tc 0.006 Tw -25.772 -1.141 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.7 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (11549631)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 267.48 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 38.88 412.32 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 390.72 Tm [(389.)-6.7 ( M)15.8 (az)-2 (z)8.8 (af)-17.5 (er)4.9 (r)-6 (i)2.7 ( E)1.9 (L,)4.2 ( K)2 (l)2.6 (oos)-2 ( R)2.6 (T.)4.3 ( C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( r)-5.9 (ev)8.9 (i)2.6 (e)-11.2 (w)13.5 ( 128)-11.3 (:)-6.6 ( C)2.7 (ur)4.9 (r)-5.9 (ent)4.2 ( app)]TJ -0.004 Tw [(r)-6 (oa)10.5 (c)-2 (hes)-2 ( t)-6.6 (o )]TJ 0.007 Tw 0 -1.152 Td [(pr)-6 (i)2.6 (m)-6 (ar)-5.9 (y)8.8 ( t)-6.6 (he)10.5 (r)-6 (apy)8.9 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( papi)2.6 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( and )11.2 (f)-17.4 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2.1 (er)-6 (.)4.3 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n E)2 (ndoc)-2 (r)-6 (i)2.6 (nol)2.6 ( )]TJ 0 -1.141 Td [(M)15.8 (et)-6.6 (ab 2001;)-6.6 (86:)-6.6 (1447)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.489 0 Td [(14)10.5 (63.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -9.489 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (11297567)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 350.76 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 329.16 Tm [(390.)-6.7 ( B)2 (ur)-6 (n)10.5 (s)-2 ( J)-2 (A)12.9 (,)-6.7 ( M)15.8 (or)-6 (g)-11.2 (en)10.5 (s)]TJ 10.696 0 Td [(t)4.3 (er)-5.9 (n K)2 (E)1.9 (,)4.3 ( C)2.6 (ahi)2.6 (l)2.6 (l)2.6 ( K)2 (V)1.9 (,)-6.6 ( et)4.2 ( al)2.6 (.)4.3 ( )11.2 (N)2.6 (as)-2 (ol)2.6 (ac)-2 (r)-6 (i)2.7 (m)-6 (al)2.6 ( obs)-2 (t)4.2 (r)-5.9 (uc)8.9 (t)-6.6 (i)2.6 (on )]TJ -10.696 -1.152 Td [(s)-2 (ec)-2 (ondar)-6 (y)8.9 ( t)-6.6 (o)10.5 ( I)4.2 (\()-5.9 (131\))4.9 ( t)-6.6 (he)10.5 (r)4.9 (apy)8.8 (.)-6.6 ( O)-6.6 (ph)10.5 (t)-6.6 (hal)2.6 ( P)2 (l)2.6 (as)-2 (t)-6.6 ( R)2.6 (ec)-2 (o)10.5 (ns)-2 (t)-6.6 (r)5 ( S)2 (ur)4.9 (g 2004;)-6.6 (20)10.5 (:)-6.6 (126)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 0 -1.141 Td [(129.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.2 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)-6.6 (g)-11.2 (ov)8.9 (/)-6.6 (pu)10.5 (bm)-5.9 (ed/)-6.6 (15083081)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 339.72 303.84 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 111.12 301.8 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 280.2 Tm [(391.)-6.7 ( H)2.7 (au)10.5 (g)-11.2 (en)]TJ 0 Tc 0 Tw 5.707 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(B)2 (R)2.6 (,)-6.6 ( K)1.9 (ane)10.5 ( )11.3 (M)4.9 (A)2 (.)-6.6 ( A)1.9 (ppr)-5.9 (oac)-2 (h)10.5 ( t)-6.6 (o)10.5 ( t)-6.6 (he)10.5 ( t)-6.6 (hy)8.9 (r)4.9 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 ( pat)-6.6 (i)2.6 (ent)4.3 ( w)13.4 (i)2.6 (t)-6.5 (h )]TJ -5.989 -1.152 Td [(ex)8.8 (t)-6.6 (r)-5.9 (ac)-2 (er)-6 (v)8.9 (i)2.6 (c)-2 (al)2.7 ( m)-5.9 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.8 (.)-6.6 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.6 (nol)2.6 ( M)15.7 (et)-6.6 (ab 2010;)-6.6 (95)10.6 (:)-6.6 (987)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 28.207 0 Td [(993)10.5 (.)-6.6 ( )]TJ 0.007 Tw -28.207 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (20203334)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 254.88 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 252.84 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc -0.026 Tw 11.04 -0 0 11.04 23.52 231.24 Tm [(392.)-6.7 ( W)-36.2 (ex)8.9 (l)2.6 (er)-6 ( )]TJ 0.007 Tw 5.598 0 Td [(J)-2 (A)2 (.)-6.7 ( )0.5 (A)1.9 (pp)10.5 (r)-6 (oac)8.9 (h t)-6.7 (o)10.6 ( t)-6.6 (he)10.5 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-5.9 ( p)10.5 (at)-6.6 (i)2.7 (ent)-6.6 ( w)13.4 (i)2.6 (t)-6.6 (h bone )]TJ -5.598 -1.152 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 (.)-6.6 ( J)8.8 ( C)2.7 (l)2.6 (i)2.6 (n E)2 (ndo)10.5 (c)-2 (r)-6 (i)2.7 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2011;)-6.6 (96:)-6.6 (22)10.5 (96)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 22.88 0 Td [(2307.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.88 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21816796)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 205.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 203.88 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 23.52 182.28 Tm [(393.)-6.7 ( O)-6.6 (r)-5.9 (i)2.6 (t)-6.7 (a)10.6 ( )-10.6 (Y)1.9 (,)4.3 ( )-10.6 (S)1.9 (u)10.6 (g)-11.2 (i)2.6 (t)-6.6 (ani)2.6 ( I)-6.6 (,)4.3 ( M)15.8 (at)]TJ 0.007 Tw 12.228 0 Td [(s)-2 (uur)-6 (a M)15.8 (,)-6.6 ( et)-6.6 ( al)2.6 (.)4.2 ( P)2 (r)-6 (o)10.6 (g)-11.3 (n)10.6 (os)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (f)-6.6 (ac)-2 (t)-6.6 (o)10.6 (r)-6 (s)-2 ( and)10.5 ( )11.3 (t)-6.6 (he )]TJ -12.228 -1.141 Td [(t)-6.6 (her)-6 (apeu)10.5 (t)-6.6 (i)2.6 (c)-2 ( s)8.9 (t)-6.6 (r)-6 (a)10.5 (t)-6.5 (e)10.5 (g)-11.3 (y)8.9 ( )11.3 (f)-17.5 (or)4.9 ( p)10.5 (at)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h bone)10.6 ( m)-6 (e)10.5 (t)-6.6 (as)-2 (t)4.2 (as)-2 (i)2.6 (s)-2 ( )11.3 (f)-6.6 (r)-6 (om)4.9 ( di)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (ent)-6.6 (i)2.6 (a)10.5 (t)-6.6 (ed )]TJ 0 -1.152 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a.)4.3 ( S)2 (ur)4.9 (g)-11.2 (e)10.5 (r)-5.9 (y)8.9 ( 2010;)-6.6 (147:)-6.6 (424)]TJ 0 Tc 0 Tw 18.283 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(431.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -18.62 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)6.6 (l)9.6 (m)]TJ -0.002 Tc 0.002 Tw 8.641 0 Td [(.)-6.6 (ni)2.6 (h.)4.3 (gov)8.8 (/)-6.6 (pubm)-6 (ed/)-6.6 (20176243)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 144.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 142.32 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 120.72 Tm [(394.)-6.7 ( Lu)10.5 (t)-6.6 (z)8.9 ( S)1.9 (,)-6.6 ( B)2 (e)10.5 (r)4.9 (k)-12.8 ( L)10.5 (,)-6.6 ( C)2.6 (ha)10.5 (ng E)2 (,)-6.6 ( e)10.5 (t)4.3 ( al)2.6 (.)-6.6 ( P)2 (al)2.7 (l)2.6 (i)2.6 (at)-6.6 (i)2.6 (v)8.9 (e )0.5 (r)-6 (adi)2.6 (ot)-6.6 (her)-6 (apy)8.9 ( )11.3 (f)-17.5 (o)10.5 (r)-6 ( bone)10.5 ( )]TJ 0 -1.152 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 (:)-6.6 ( an)10.6 ( A)2 (S)12.8 (T)-10.5 (R)2.6 (O)4.2 ( )11.3 (ev)8.8 (i)2.6 (denc)-2 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 15.054 0 Td [(bas)-2 (ed g)-11.2 (ui)2.7 (del)2.6 (i)2.6 (ne.)-6.6 ( )11.3 (I)-6.7 (nt)4.3 ( J)-1.9 ( R)2.7 (adi)2.6 (at)4.3 ( )11.3 (O)-6.6 (nc)-2 (ol)2.6 ( B)1.9 (i)2.6 (ol)2.6 ( )]TJ -15.054 -1.141 Td [(P)2 (hy)8.9 (s)-2 ( 2011;)-6.6 (79:)-6.6 (965)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 8.38 0 Td [(976)10.5 (.)4.3 ( A)1.9 (v)8.9 (ai)-8.2 (l)2.6 (abl)2.6 (e )-10.7 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -8.38 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21277118)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 82.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 80.64 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 59.04 Tm [(395.)-6.7 ( H)2.7 (enr)-6 (y)8.9 ( D)2.6 (H)2.6 (,)4.2 ( )0.5 (C)2.6 (os)-2 (t)-6.6 (a)10.5 ( L,)4.2 ( )0.5 (G)-6.7 (ol)2.6 (dw)13.4 (as)-2 (s)-2 (er)-5.9 ( F)11.2 (,)-6.7 ( e)10.6 (t)-6.6 ( al)2.6 (.)4.3 ( R)2.6 (a)10.5 (ndom)-6 (i)2.6 (z)8.9 (ed,)-6.6 ( doubl)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 29.75 0 Td [(bl)2.6 (i)2.6 (nd )]TJ 0.007 Tw -29.75 -1.141 Td [(s)-2 (t)-6.6 (udy)8.9 ( o)10.5 (f)-17.5 ( )11.3 (denos)-2 (um)-5.9 (ab)10.5 ( v)8.8 (er)4.9 (s)-2 (us)-2 ( z)8.9 (ol)2.6 (edr)-6 (oni)2.6 (c)-2 ( )0.5 (ac)-2 (i)2.6 (d i)2.6 (n )11.3 (t)-6.6 (h)10.5 (e t)4.2 (r)-5.9 (eat)4.2 (m)-5.9 (ent)4.2 ( o)10.6 (f)-6.6 ( bone)10.5 ( )]TJ 34.554 42.348 Td [(m)-6 (et)-6.6 (as)8.9 (t)-6.6 (as)-2 (es)8.9 ( i)2.6 (n pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h adv)8.9 (anc)-2 (ed c)-2 (anc)-2 (e)10.6 (r)-6 ( )11.3 (\()-6 (ex)8.8 (c)-2 (l)2.7 (udi)2.6 (ng)-11.2 ( br)-6 (ea)10.6 (s)-2 (t)4.2 ( and )]TJ 0 Tc 0 Tw 0 -1.152 Td (p)Tj -0.002 Tc 0.007 Tw 0.554 0 Td [(r)-6 (os)-2 (t)-6.6 (a)10.5 (t)-6.6 (e c)-2 (an)10.5 (c)-2 (er)4.9 (\))-6 ( o)10.6 (r)-6 ( )11.3 (m)-6 (ul)2.6 (t)-6.6 (i)13.5 (pl)2.6 (e m)-6 (y)8.9 (el)2.7 (om)-6 (a.)-6.6 ( )11.3 (J)-2 ( C)2.6 (l)2.6 (i)2.6 (n O)-6.6 (n)10.6 (c)8.8 (ol)2.6 ( 2011;)-6.6 (29:)-6.6 (1125)]TJ 0 Tc 0 Tw 28.13 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(1132.)4.3 ( )]TJ 0.007 Tw -29.022 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (21343556)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 488.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 486.6 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 465 Tm [(396.)-6.7 ( R)2.7 (os)-2 (en)10.5 ( LS)2 (,)4.2 ( )0.5 (G)-6.6 (o)10.5 (r)-6 (don )11.2 (D)2.6 (,)-6.6 ( )11.3 (T)-10.5 (c)-2.1 (he)10.5 (k)-2 (m)-5.9 (edy)8.8 (i)2.7 (an N)2.6 (S)1.9 (,)-6.6 ( et)4.2 ( )11.3 (al)2.7 (.)-6.7 ( )0.5 (Lon)10.6 (g)]TJ 0 Tc 0 Tw 25.38 0 Td (-)Tj 0.005 Tc 0.326 0 Td [(te)6.6 (r)12 (m)1 ( e)17.5 (ffi)9.6 (c)5 (a)6.7 (c)5 (y)15.9 ( )]TJ -0.002 Tc 0.007 Tw -25.707 -1.152 Td [(and s)-2 (a)10.5 (f)-17.5 (e)10.5 (t)-6.6 (y)8.9 ( o)10.5 (f)-6.6 ( z)8.9 (ol)2.6 (edr)-5.9 (oni)2.6 (c)-2 ( ac)-1.9 (i)2.6 (d i)2.6 (n t)-6.6 (he)10.5 ( t)4.3 (r)-6 (eat)4.3 (m)-6 (ent)4.2 ( o)10.5 (f)-6.6 ( s)8.9 (k)-12.9 (el)2.6 (et)-6.6 (al)13.5 ( m)-6 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (a)10.5 (s)-2 (es)-2.1 ( )0.5 (i)2.6 (n )]TJ 0 -1.141 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h nons)8.9 (m)-6 (al)2.6 (l)2.6 ( c)8.8 (el)2.6 (l)2.6 ( l)2.6 (ung)-11.2 ( c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.6 ( and o)10.5 (t)4.3 (her)-5.9 ( s)-2.1 (ol)2.6 (i)2.6 (d )11.3 (t)-6.7 (um)-6 (o)10.6 (r)-6 (s)-2 (:)4.3 ( a )]TJ 0 -1.152 Td [(r)-6 (andom)-6 (i)2.6 (z)8.9 (ed,)-6.6 ( P)1.9 (has)-2 (e)10.6 ( I)4.2 (I)-6.6 (I)4.3 (,)-6.6 ( d)10.5 (oubl)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.576 0 Td [(bl)2.6 (i)2.6 (nd,)-6.6 ( pl)2.6 (ac)-2 (ebo)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 6.489 0 Td [(c)-2 (on)10.5 (t)-6.6 (r)-6 (ol)2.6 (l)2.6 (ed t)4.2 (r)-5.9 (i)2.6 (al)2.7 (.)-6.7 ( C)2.7 (anc)-2 (e)10.5 (r)-6 ( )]TJ 0.002 Tw -20.065 -1.141 Td [(2004;)-6.6 (100:)-6.6 (2613)]TJ 0 Tc 0 Tw 6.652 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(2621.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.989 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (15197804)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 401.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 399.72 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 378 Tm [(397.)-6.7 ( V)2 (i)2.6 (t)-6.6 (al)2.6 (e )11.3 (G)4.2 (,)-6.6 ( Fonde)10.5 (r)-5.9 (i)2.6 (c)-2 (o )11.3 (F,)-6.6 ( M)15.8 (ar)-5.9 (t)-6.6 (i)2.6 (g)-11.2 (ne)10.5 (t)-6.6 (t)-6.6 (i)13.5 ( A)2 (,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( P)1.9 (a)10.6 (m)-6 (i)2.6 (dr)-6 (onat)-6.6 (e)10.5 ( i)2.6 (m)-6 (p)10.6 (r)-6 (ov)8.8 (es)-2 ( t)-6.6 (he)10.6 ( )]TJ 0 -1.141 Td [(q)-11.2 (ual)2.6 (i)2.6 (t)-6.6 (y)8.9 ( o)10.5 (f)-6.6 ( l)2.6 (i)2.6 (f)-17.5 (e)10.5 ( and)10.6 ( i)2.6 (nduc)-2 (es)-2 ( c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( r)-5.9 (em)-5.9 (i)2.6 (s)-2 (s)-2 (i)2.6 (on o)10.5 (f)-6.6 ( bo)10.5 (ne m)-6 (e)10.6 (t)-6.7 (as)-2 (t)-6.6 (a)10.5 (s)-2 (es)-2 ( i)2.6 (n)10.5 ( pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( )]TJ -0.005 Tc 0.01 Tw 0 -1.141 Td [(wit)-9.6 (h)-3.4 ( t)-9.6 (h)-3.3 (y)]TJ -0.002 Tc 0.007 Tw 3.38 0 Td [(r)-6 (oi)2.6 (d c)-2.1 (anc)-2 (e)10.5 (r)-6 (.)4.3 ( B)1.9 (r)5 ( J)-2 ( )11.2 (C)2.6 (anc)-2 (er)-6 ( 2001)10.5 (;)-6.6 (84:)-6.6 (1586)]TJ 0 Tc 0 Tw 17.12 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(15)10.5 (90.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -20.837 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (11401309)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 340.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 338.04 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 316.44 Tm [(398.)-6.7 ( E)2 (us)8.8 (t)-6.6 (at)-6.6 (i)2.6 (a)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 6.163 0 Td [(R)2.6 (u)10.5 (t)-6.6 (t)-6.6 (en)10.5 ( C)2.6 (F,)4.3 ( R)2.6 (om)-5.9 (i)2.6 (j)-8.3 (n)10.6 ( J)-2 (A)2 (,)4.3 ( )11.2 (G)-6.6 (ui)2.6 (j)-8.3 (t)4.3 ( M)15.8 (J)-2 (,)-6.7 ( et)4.3 ( )11.2 (al)2.6 (.)-6.6 ( O)-6.6 (u)10.5 (t)-6.6 (c)-2 (o)10.5 (m)-5.9 (e o)10.5 (f)-6.6 ( pal)2.6 (l)2.6 (i)2.7 (at)-6.6 (i)2.6 (v)8.9 (e )]TJ -6.163 -1.141 Td [(em)-6 (bol)2.6 (i)2.6 (z)8.9 (at)-6.6 (i)2.7 (on )0.5 (of)-6.6 ( bo)]TJ [(ne)10.5 ( m)-6 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (as)-2 (e)10.6 (s)-2 ( i)2.6 (n di)13.4 (f)-6.6 (f)-6.6 (er)4.9 (ent)-6.6 (i)2.6 (at)-6.7 (ed)10.5 ( )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a.)4.3 ( J)-2 ( C)2.6 (l)2.6 (i)2.6 (n )]TJ 0 -1.152 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2003;)-6.6 (8)10.6 (8:)-6.6 (3184)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.467 0 Td [(3189)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.467 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (12843163)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 278.52 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 276.48 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 254.88 Tm [(399.)-6.7 ( C)2.7 (ar)-5.9 (hi)2.6 (l)2.6 (l)2.6 ( A)2 (A)1.9 (,)4.3 ( C)2.6 (abani)2.7 (l)2.5 (l)-8.2 (as)-1.9 ( M)15.7 (E)2 (,)-6.6 ( J)-2 (i)2.6 (m)-6 (enez)8.8 ( )0.5 (C)2.6 (,)-6.6 ( e)10.6 (t)-6.6 ( al)13.5 (.)-6.6 ( )11.3 (T)-10.6 (he)10.6 ( noni)2.6 (nv)8.8 (es)-2 (t)-6.6 (i)2.6 (g)-11.2 (at)-6.7 (i)2.7 (onal)2.6 ( )]TJ 0 -1.152 Td [(us)-2 (e o)10.5 (f)-6.6 ( t)-6.6 (y)8.9 (r)-6 (os)-2 (i)2.6 (ne )11.3 (k)-12.9 (i)2.6 (nas)-2 (e)10.5 ( i)2.6 (n)10.6 (hi)2.6 (bi)2.6 (t)-6.6 (or)-5.9 (s)-2 ( i)2.6 (n )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 (:)4.2 ( es)-2 (t)-6.7 (abl)2.6 (i)2.6 (s)-2 (hi)2.6 (ng a )11.3 (s)-2 (t)-6.6 (anda)10.5 (r)-5.9 (d )]TJ 0 -1.141 Td [(f)-6.6 (or)5 ( pat)-6.7 (i)2.7 (ent)4.2 ( s)-2 (a)10.6 (f)-6.7 (et)-6.6 (y)8.9 ( and )11.3 (m)-6 (o)10.6 (ni)2.6 (t)-6.6 (or)-6 (i)2.6 (ng.)-6.6 ( )11.3 (J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.6 (no)10.5 (l)2.6 ( M)15.8 (et)-6.7 (ab 2013;)-6.6 (98:)-6.7 (31)]TJ 0 Tc 0 Tw 30.576 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(42.)4.3 ( )]TJ 0.007 Tw -30.913 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (23185034)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 216.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 214.92 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 193.32 Tm [(400.)-6.7 ( V)2 (an)10.5 ( N)2.6 (os)-2 (t)-6.6 (r)5 (and D)2.6 (,)4.3 ( A)1.9 (t)4.3 (k)-12.9 (i)2.6 (ns)8.8 ( F,)4.2 ( Y)2 (eg)-11.2 (ane)10.5 (h F)11.2 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( )11.3 (D)2.6 (os)-2 (i)2.6 (m)-5.9 (et)-6.6 (r)-5.9 (i)2.6 (c)-2 (al)2.6 (l)2.6 (y)8.9 ( )]TJ 0 -1.152 Td [(det)-6.6 (er)5 (m)-6 (i)2.6 (ned dos)-2 (es)8.9 ( o)10.5 (f)-6.6 ( r)-5.9 (adi)13.5 (oi)2.6 (odi)2.6 (ne f)-17.5 (o)10.6 (r)-6 ( )11.3 (t)-6.6 (he)10.6 ( t)4.2 (r)-5.9 (eat)4.2 (m)-5.9 (ent)4.2 ( )11.3 (o)10.5 (f)-17.5 ( )11.3 (m)-5.9 (et)-6.6 (as)8.9 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ -0.004 Tw 0 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (2002)10.5 (;)-6.6 (12:)-6.6 (121)]TJ 0 Tc 0 Tw 14.293 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td (13)Tj 0.007 Tw [(4.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.63 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (11916281)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 155.28 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 153.24 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 131.64 Tm [(401.)-6.7 ( B)2 (r)-6 (o)10.6 (s)-2 (e M)15.8 (S)2 (,)-6.7 ( )22.2 (W)-36.3 (o)10.6 (r)4.9 (den )11.3 (FP)2 (,)-6.7 ( )0.5 (N)2.6 (ew)13.5 (bol)2.6 (d K)1.9 (L,)-6.6 ( et)4.3 ( al)2.6 (.)-6.6 ( E)12.8 (f)-6.6 (f)-6.6 (ec)8.9 (t)-6.7 ( o)10.6 (f)-6.6 ( A)12.8 (g)-11.2 (e)10.5 ( on )11.3 (t)-6.7 (he )]TJ 0 -1.141 Td [(E)2 (f)-6.7 (f)-6.6 (i)2.6 (c)-1.9 (ac)-2 (y)8.9 ( and S)2 (a)10.5 (f)-6.6 (et)-6.7 (y)8.9 ( o)10.5 (f)-6.6 ( Le)10.5 (nv)8.9 (at)-6.6 (i)2.6 (ni)2.7 (b i)2.6 (n R)2.7 (adi)2.6 (oi)2.6 (odi)2.7 (ne)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 21.37 0 Td [(R)-8.3 (e)10.6 (f)-17.5 (r)-6 (ac)8.8 (t)-6.6 (or)-6 (y)8.9 ( D)2.6 (i)13.5 (f)-6.6 (f)-17.5 (e)10.5 (r)-5.9 (en)]TJ 0.002 Tw [(t)-6.6 (i)2.6 (a)10.5 (t)-6.6 (ed )]TJ 0.007 Tw -21.37 -1.152 Td [(T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d C)2.6 (anc)-2 (er)4.9 ( i)2.6 (n )11.2 (t)-6.6 (he P)2 (h)10.5 (as)-2 (e I)4.3 (I)-6.6 (I)4.2 ( S)2 (E)1.9 (LE)1.9 (C)2.7 (T )11.3 (T)-10.5 (r)-6 (i)2.6 (al)2.6 (.)4.2 ( J)-2 ( )11.3 (C)2.6 (l)2.6 (i)2.6 (n O)-6.6 (nc)-2 (ol)2.6 ( 2017;)-6.6 (35)10.6 (:)-6.6 (2692)]TJ 0 Tc 0 Tw 32.402 0 Td (-)Tj -0.002 Tc 0.007 Tw -32.402 -1.141 Td [(2699.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (ps)8.8 (:)4.3 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.4 (.)-6.5 (nc)-2 (bi)2.6 (.)-6.7 (nl)2.6 (m)-5.9 (.)-6.7 (ni)2.6 (h.)-6.6 (g)-11.3 (ov)8.9 (/)-6.6 (p)10.5 (ubm)-6 (ed/)-6.6 (28613956)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 732.84 93.72 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 498.72 91.68 234.121 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 70.08 Tm [(402.)-6.7 ( )11.3 (T)-10.5 (ho)10.5 (m)-5.9 (as)-2 ( L)10.6 (,)4.2 ( Lai)2.6 ( S)2 (Y)1.9 (,)4.3 ( )11.3 (D)2.6 (ong)-11.2 ( )33 (W)-36.3 (,)4.3 ( )11.2 (et)4.3 ( al)2.6 (.)4.3 ( S)1.9 (or)-6 (a)10.5 (f)-6.6 (eni)2.6 (b i)2.6 (n)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc -0.004 Tw 22.88 0 Td [(m)-6 (e)10.6 (t)-6.6 (as)8.9 (t)-6.6 (at)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0.007 Tw -22.88 -1.141 Td [(c)-2 (anc)-2 (er)-6 (:)4.3 ( a )11.3 (s)-2 (y)8.8 (s)-1.9 (t)-6.7 (em)-5.9 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( r)-6 (ev)8.8 (i)2.6 (ew)13.5 (.)-6.6 ( O)-6.6 (nc)-2 (ol)2.6 (og)-11.2 (i)2.6 (s)8.9 (t)-6.6 ( 2014)10.6 (;)-6.6 (19:)4.2 (251)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 23.663 0 Td [(258.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -23.663 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24563075)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 44.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 42.72 228.72 0.84 re f EMC endstream endobj 1080 0 obj 28865 endobj %% Contents for page 127 %% Original object ID: 255 0 1081 0 obj << /Length 1082 0 R >> stream Q q BT /Xi125 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1082 0 obj 246 endobj %% Original object ID: 11897 0 1083 0 obj [ 3049 0 R 3050 0 R 3051 0 R 3052 0 R 3053 0 R 3054 0 R 3055 0 R 3056 0 R 3057 0 R 3058 0 R 3059 0 R 3060 0 R 3061 0 R 3062 0 R 3063 0 R ] endobj %% Contents for page 128 %% Original object ID: 256 0 1084 0 obj << /Length 1085 0 R >> stream q endstream endobj 1085 0 obj 2 endobj %% Contents for page 128 %% Original object ID: 11898 0 1086 0 obj << /Length 1087 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (65)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(403.)-6.7 ( Fal)2.6 (l)2.6 (ahi)2.7 ( P)2 (,)-6.6 ( F)11.2 (er)-5.9 (r)-6 (a)10.5 (r)-5.9 (i)2.6 ( S)12.8 (M)15.8 (,)-6.6 ( V)1.9 (i)2.6 (t)-6.6 (a R)2.6 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.7 (.)4.2 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )11.3 (dy)8.9 (s)-2 (f)-17.5 (unc)8.9 (t)-6.6 (i)]TJ 25.141 0 Td [(ons)-2 ( i)2.6 (nduc)-2 (ed by)8.9 ( )]TJ -25.141 -1.152 Td [(t)-6.6 (y)8.9 (r)-6 (os)-2 (i)2.6 (ne )11.2 (k)-12.8 (i)2.6 (nas)-2 (e i)2.7 (nhi)2.6 (bi)2.6 (t)-6.6 (or)-6 (s)8.9 (.)-6.6 ( E)1.9 (x)8.9 (per)-5.9 (t)4.2 ( O)-6.6 (pi)2.6 (n)10.5 ( D)2.6 (r)-5.9 (u)10.5 (g)-11.2 ( S)2 (a)10.5 (f)-6.6 ( 2)10.5 (014;)-6.6 (13:)-6.6 (723)]TJ 0 Tc 0 Tw 26.761 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(733.)4.2 ( )]TJ 0.007 Tw -27.098 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (24821006)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 488.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 486.6 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 465 Tm [(404.)-6.7 ( M)15.8 (c)-2 (H)2.6 (enr)-5.9 (y)8.9 ( C)2.6 (R)2.6 (,)-6.6 ( S)1.9 (andov)8.9 (al)2.6 ( B)1.9 (A)2 (.)-6.6 ( M)15.7 (anag)-11.2 (em)-6 (ent)4.3 ( o)10.5 (f)-6.6 ( )11.2 (f)-17.4 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( and H)2.6 (u)10.5 (r)-6 (t)-6.6 (hl)2.6 (e )11.3 (c)-2 (el)2.6 (l)2.6 ( )]TJ -0.004 Tw 0 -1.152 Td [(neopl)2.6 (as)-2 (m)-6 (s)-2 ( )-10.6 (o)10.5 (f)-6.6 ( t)-6.6 (he t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d g)-11.2 (l)2.6 (and.)-6.6 ( )-10.5 (S)1.9 (u)10.5 (r)4.9 (g)-11.2 ( O)-6.6 (nc)-2 (ol)2.6 ( )-10.6 (C)2.6 (l)2.6 (i)2.6 (n N)2.6 ( )-10.6 (A)2 (m)-6 ( )-10.6 (1998)10.5 (;)-6.6 (7:)-6.6 (8)10.5 (93)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 29.478 0 Td [(910)10.5 (.)-6.6 ( )]TJ 0.007 Tw -29.478 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (9735140)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 309.12 439.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 437.64 222.48 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 416.04 Tm [(405.)-6.7 ( U)2.7 (s)8.8 (t)-6.6 (un B)12.9 (,)-6.7 ( C)2.7 (hhi)2.6 (en)10.5 (g)-11.2 ( D)13.5 (,)-6.6 ( V)2 (an )0.5 (D)2.6 (y)19.7 (k)-12.9 (e A)12.8 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( R)2.6 (i)2.6 (s)8.9 (k)-12.9 ( )11.3 (s)-2 (t)-6.6 (r)-5.9 (a)10.5 (t)-6.6 (i)13.4 (f)-17.4 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (on i)2.7 (n)10.5 ( )11.2 (f)-17.4 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( )]TJ 0 -1.152 Td [(neopl)2.6 (as)-2 (m)-6 (:)4.3 ( a c)-2 (y)8.9 (t)-6.6 (ol)2.7 (o)10.5 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( )11.3 (as)-2 (s)-2 (es)-2 (s)-2 (m)-5.9 (en)10.5 (t)-6.6 ( u)10.5 (s)-1.9 (i)2.6 (ng t)-6.6 (he)10.5 ( )11.3 (m)4.9 (odi)2.6 (f)-17.5 (i)2.7 (ed B)1.9 (e)10.5 (t)-6.6 (hes)-2 (da)10.5 ( )]TJ 0 -1.141 Td [(c)-2 (l)2.6 (as)-2 (s)-2 (i)2.6 (f)-17.5 (i)2.6 (c)-2 (a)10.5 (t)-6.6 (i)2.6 (on.)-6.6 ( C)2.6 (anc)-2 (e)10.6 (r)-6 ( C)2.6 (y)8.9 (t)-6.6 (opat)-6.6 (hol)2.6 ( )0.5 (2014)10.5 (;)-6.6 (122:)-6.6 (53)10.6 (6)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 21.174 0 Td [(5)10.5 (45.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -21.174 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24753500)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 378 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 375.96 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 354.36 Tm [(406.)-6.7 ( P)2 (hi)2.6 (t)-6.6 (ay)8.9 (ak)-2 (or)-6 (n)10.6 ( R)2.6 (,)-6.6 ( M)15.8 (c)-2 (H)2.6 (enr)-6 (y)8.9 ( C)2.6 (R)2.6 (.)-6.6 ( Fol)2.6 (l)2.7 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( and )11.3 (H)2.6 (ur)-5.9 (t)-6.7 (hl)2.6 (e c)-2 (el)2.6 (l)2.6 ( c)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.141 Td [(t)-6.6 (he )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d g)-11.2 (l)2.6 (and)10.6 (.)-6.6 ( S)1.9 (u)10.5 (r)5 (g)-11.3 ( )11.3 (O)4.2 (nc)-2 (ol)2.6 ( C)2.6 (l)2.6 (i)2.6 (n N)2.6 ( A)1.9 (m)-5.9 ( 2006)10.5 (;)-6.6 (15:)4.3 (603)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 23.826 0 Td [(623,)4.2 ( i)2.6 (x)]TJ 0 Tc 0 Tw 2.924 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(x)8.9 (.)-6.6 ( A)1.9 (v)8.9 (ai)-8.2 (l)2.6 (abl)2.6 (e )]TJ -0.006 Tc 0.006 Tw -27.087 -1.141 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (16882500)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 267.48 329.16 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 38.88 327.12 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 305.52 Tm [(407.)-6.7 ( )11.3 (T)-10.5 (ho)10.5 (m)-5.9 (ps)-2 (on)10.5 ( LD)2.7 (,)-6.6 ( )33 (W)-36.3 (i)13.5 (e)10.5 (nek)-12.9 (e)10.6 ( J)-2 (A)1.9 (,)4.3 ( P)1.9 (aal)2.7 ( E)1.9 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( A)2 ( )11.2 (c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (opat)-6.6 (hol)2.6 (og)-11.2 (i)2.6 (c)-2 ( s)8.9 (t)-6.6 (udy)8.9 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.152 Td [(m)-6 (i)2.7 (ni)2.6 (m)-5.9 (al)2.6 (l)2.6 (y)8.9 ( i)2.6 (n)-11.2 (v)8.9 (as)-2 (i)-8.2 (v)8.8 (e f)-17.5 (ol)2.6 (l)2.6 (i)2.6 (c)-2 (ul)2.6 (ar)-6 ( c)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.6 ( t)-6.6 (hy)8.9 (r)-6 (o)10.6 (i)2.6 (d g)-11.2 (l)2.6 (and w)13.4 (i)2.6 (t)-6.6 (h a )11.2 (r)-6 (ev)8.9 (i)2.6 (ew)13.5 ( of)-17.5 ( )]TJ 0 -1.141 Td [(t)-6.6 (he E)1.9 (n)10.6 (g)-11.2 (l)2.6 (i)2.6 (s)-2 (h l)2.6 (i)2.7 (t)-6.7 (er)-6 (a)10.6 (t)-6.6 (ur)-6 (e)10.6 (.)-6.6 ( C)2.6 (a)10.5 (nc)-2.1 (er)-6 ( )0.5 (2001)10.5 (;)-6.6 (91:)-6.6 (505)]TJ 0 Tc 0 Tw 18.674 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td (524.)Tj 0 Tc 0 Tw 1.935 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(A)12.8 (v)8.9 (ai)-8.2 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -21.228 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (11169933)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 267.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 265.44 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 243.84 Tm [(408.)-6.7 ( H)2.7 (edi)2.6 (n)10.5 (g)-11.2 (er)5 ( C)2.7 (E)1.9 (.)-6.6 ( )11.3 ([)-6.6 (P)1.9 (r)-5.9 (obl)13.4 (em)-6 (s)-2 ( )0.5 (i)2.6 (n)10.5 ( t)-6.6 (he)10.6 ( c)-2 (l)2.6 (as)-2 (s)-2 (i)13.5 (f)-17.5 (i)2.6 (c)-2 (at)-6.6 (i)2.6 (on )11.3 (o)10.5 (f)-17.5 ( )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d t)-6.6 (u)10.5 (m)-5.9 (or)-6 (s)8.9 (.)-6.7 ( )11.3 (T)-10.5 (hei)2.6 (r)4.9 ( )]TJ 0 -1.141 Td [(s)-2 (i)2.6 (g)-11.2 (ni)13.5 (f)-17.4 (i)2.6 (c)-2 (anc)-2 (e)10.5 ( )11.3 (f)-17.5 (o)10.5 (r)-6 ( p)10.6 (r)-6 (o)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)-2 ( and )11.3 (t)-6.7 (her)-5.9 (apy)8.9 (])4.2 (.)-6.6 ( S)2 (c)-2 (hw)13.5 (ei)2.6 (z)8.8 ( )-10.4 (M)15.8 (ed )22.1 (W)-36.3 (oc)-2 (hens)-2 (c)]TJ -0.013 Tc 0.013 Tw 28.489 0 Td [(hr)-16.9 ( )]TJ -0.002 Tc 0.002 Tw -28.489 -1.152 Td [(1993;)-6.6 (123:)-6.6 (1673)]TJ 0 Tc 0 Tw 6.652 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1681.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.989 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8211018)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 205.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 203.88 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 182.28 Tm [(409.)-6.7 ( )11.3 (G)-6.6 (o)10.5 (f)-6.6 (f)-6.6 (r)-5.9 (edo)10.5 ( P)1.9 (,)4.3 ( R)2.6 (om)-6 (an)10.5 ( )11.2 (S)2 (A)2 (,)-6.6 ( S)1.9 (os)-2 (a )11.3 (J)-2 (A)2 (.)-6.7 ( H)2.6 (u)10.6 (r)-6 (t)-6.6 (hl)2.6 (e )11.3 (c)-2 (el)2.6 (l)2.7 ( c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.5 (:)-6.6 ( a)10.5 ( )]TJ 0.002 Tw 0 -1.141 Td [(popul)2.6 (at)-6.6 (i)2.6 (on)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 4.935 0 Td [(l)2.6 (ev)8.8 (el)2.6 ( anal)-8.2 (y)8.9 (s)-2 (i)2.6 (s)-12.9 ( o)10.5 (f)-6.6 ( 3311 pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 (.)-6.6 ( C)2.6 (anc)-2 (e)10.5 (r)-6 ( 201)]TJ 0.002 Tw [(3)10.5 (;)-6.6 (119:)-6.6 (504)]TJ 0 Tc 0 Tw 23.435 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(511.)4.2 ( )]TJ 0.007 Tw -28.707 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (22893587)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 156.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 154.92 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 133.32 Tm [(410.)-6.7 ( S)2 (u)10.5 (g)-11.2 (i)2.6 (no K)12.9 (,)-6.7 ( )11.3 (I)-6.6 (t)-6.6 (o)10.5 ( K)2 (,)4.2 ( M)15.8 (i)-8.2 (m)-6 (ur)-5.9 (a)10.5 ( )11.3 (T)-10.6 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( H)2.6 (ur)-6 (t)-6.6 (hl)2.6 (e)10.5 ( c)-2 (el)2.5 (l)2.7 ( t)-6.6 (um)-5.9 (o)10.5 (r)-6 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (he)10.6 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d:)-6.6 ( )]TJ 0 -1.141 Td [(anal)2.6 (y)8.8 (s)-2 (i)2.7 (s)-2.1 ( of)-17.5 ( 188)10.6 ( c)-2 (as)-2 (e)10.5 (s)-2 (.)4.3 ( )22.1 (W)-14.5 (or)-5.9 (l)2.6 (d J)-2 ( S)1.9 (u)10.5 (r)4.9 (g)-11.2 ( 2001)10.5 (;)-6.6 (25:)-6.6 (116)10.5 (0)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 22.554 0 Td [(1163.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.554 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (11571953)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 108 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 105.96 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 84.36 Tm [(411.)-6.7 ( H)2.7 (er)4.9 (r)-5.9 (er)-5.9 (a)10.5 ( M)15.8 (F,)-6.6 ( H)2.6 (ay)8.9 ( I)-6.6 (D)2.6 (,)-6.6 ( )33 (W)-36.3 (u)10.6 ( P)2 (S)2 (,)4.2 ( et)4.2 ( al)2.6 (.)4.3 ( H)2.6 (ur)-5.9 (t)-6.6 (hl)2.6 (e)10.5 ( c)8.9 (el)2.6 (l)2.6 ( \()-6 (ox)8.8 (y)8.9 (ph)-11.2 (i)2.6 (l)2.6 (i)2.6 (c)-2 (\))-6 ( papi)2.6 (l)2.6 (l)2.6 (ar)-16.9 (y)8.9 ( )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a:)4.3 ( a v)8.8 (ar)-6 (i)2.6 (ant)-6.7 ( w)13.5 (i)2.6 (t)-6.6 (h m)-6 (o)10.5 (r)-5.9 (e a)10.6 (ggr)-6 (es)-2 (s)-2 (i)2.6 (v)8.8 (e bi)2.6 (ol)2.6 (og)]TJ -0.015 Tw 24.88 0 Td [(i)2.6 (c)-2 ( )-21.6 (behav)8.9 (i)2.6 (or)-5.9 (.)4.2 ( W)-36.3 (o)10.5 (r)-5.9 (l)2.6 (d)10.5 ( )]TJ 0.007 Tw -24.88 -1.152 Td [(J)-2 ( S)2 (ur)4.9 (g 1992;)-6.6 (16)10.6 (:)-6.7 (669)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.043 0 Td [(674)10.5 (;)4.3 ( di)2.7 (s)-2.1 (c)-2 (us)-2 (s)-2 (i)2.6 (on 774)]TJ 0 Tc 0 Tw 8.793 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(665.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -18.174 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (1413835)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 46.44 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 44.4 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(412.)-6.7 ( C)2.7 (hi)2.6 (ndr)-5.9 (i)2.6 (s)-2 ( A)1.9 (M)15.8 (,)-6.6 ( C)2.6 (as)-2 (l)2.6 (er)5 ( J)-1.9 (D)2.5 (,)4.3 ( B)2 (er)-5.9 (net)4.2 ( V)2 (J)8.9 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( and m)-6 (ol)2.6 (ec)-1.9 (ul)2.6 (ar)4.9 ( )]TJ 0.002 Tw 0 -1.152 Td [(f)-6.6 (eat)-6.6 (u)10.5 (r)]TJ 0.007 Tw 2.554 0 Td [(es)-2 ( o)10.5 (f)-6.6 ( H)2.6 (u)10.5 (r)-6 (t)-6.6 (hl)2.6 (e )11.3 (c)-2 (el)2.6 (l)2.6 ( c)8.9 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a )11.2 (o)10.6 (f)-6.6 ( t)-6.7 (he)10.5 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d.)4.3 ( )11.2 (J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab )]TJ 0.002 Tw -2.554 -1.141 Td [(2015;)-6.6 (100:)-6.6 (55)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(62.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)-8.3 (e at)4.3 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (25259908)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 473.88 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 452.28 Tm [(413.)-6.7 ( )33.1 (W)-36.3 (el)2.7 (l)2.6 (s)8.8 ( S)2 (A)1.9 (,)-6.6 ( J)8.9 (r)-6 (.)4.3 (,)4.3 ( A)1.9 (s)-2 (a )11.3 (S)1.9 (L,)-6.6 ( D)2.7 (r)-6 (al)2.6 (l)2.6 (e H)2.6 (,)4.3 ( et)4.3 ( al)2.6 (.)4.2 ( R)2.6 (ev)8.9 (i)2.6 (s)-12.9 (ed)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc -0.004 Tw 22.717 0 Td [(am)-6 (e)10.5 (r)-5.9 (i)2.6 (c)-2 (an t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ -22.717 -1.141 Td [(as)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (i)2.6 (on g)-11.3 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( f)-17.5 (o)10.5 (r)-5.9 ( t)-6.6 (he m)-6 (ana)10.5 (g)-11.2 (em)-5.9 (en)10.5 (t)4.3 ( )-10.6 (o)10.5 (f)-6.6 ( )-10.6 (m)-5.9 (e)10.5 (dul)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( )-10.6 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (2015)10.5 (;)-6.6 (25:)-6.6 (567)]TJ 0 Tc 0 Tw 14.293 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(610.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.63 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (25810047)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 412.32 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 390.72 Tm [(414.)-6.7 ( K)2 (l)2.6 (oos)-2 ( R)13.5 (T,)-6.6 ( E)1.9 (n)10.6 (g C)]TJ 9.641 0 Td [(,)-6.6 ( E)12.8 (v)8.9 (ans)-2 ( D)2.6 (B)1.9 (,)-6.6 ( et)4.3 ( al)2.6 (.)-6.6 ( M)15.8 (edul)2.7 (l)2.6 (ar)-5.9 (y)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (e)10.6 (r)-6 (:)4.3 ( )]TJ -0.004 Tw -9.641 -1.152 Td [(m)-6 (ana)10.6 (g)-11.2 (em)-5.9 (en)10.5 (t)-6.6 ( g)-11.2 (ui)2.6 (del)2.6 (i)2.7 (nes)-2 ( o)10.6 (f)-17.5 ( t)-6.6 (he )-10.7 (A)12.9 (m)-6 (er)-6 (i)2.6 (c)-2 (an Thy)8.9 (r)-5.9 (oi)2.6 (d )-10.6 (A)1.9 (s)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (i)2.6 (on.)-6.6 ( T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0.002 Tw 0 -1.141 Td [(2009;)-6.6 (19:)-6.6 (565)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(612.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19469690)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 350.76 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 405 329.16 Tm [(415.)-6.7 ( G)-6.6 (a)10.5 (g)]TJ 0.007 Tw 4.109 0 Td [(el)2.6 ( R)2.6 (F,)4.2 ( H)2.6 (o)10.6 (f)-6.7 (f)-6.5 ( A)12.9 (O)-6.6 (,)4.2 ( C)2.6 (ot)-6.6 (e )11.3 (G)-6.6 (J)8.9 (.)-6.6 ( M)15.8 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )0.5 (c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-6 (a)10.5 (.)-6.6 ( )11.3 (I)-6.6 (n:)4.3 ( )]TJ -4.109 -1.152 Td [(B)2 (r)-6 (av)8.8 (er)-6 (m)-5.9 (an LE)12.8 (,)-6.5 ( U)2.6 (t)-6.5 (i)13.4 (g)-11.2 (e)10.5 (r)-5.9 ( R)13.4 (D)2.7 (,)-6.7 ( )0.5 (eds)8.8 (.)-6.6 ( )33 (W)-36.2 (e)10.5 (r)-6 (ne)10.5 (r)-5.9 ( and)10.5 ( I)-6.6 (n)10.5 (g)-11.2 (b)10.5 (ar)-5.9 (')-6.7 (s)8.9 ( )11.3 (T)-10.6 (he )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d:)4.3 ( A)1.9 ( )]TJ 0 -1.141 Td [(Fundam)-5.9 (ent)-6.6 (al)2.6 ( and)10.6 ( C)2.7 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( T)-10.6 (ex)8.9 (t)-6.7 (,)4.3 ( 9t)-6.6 (h)10.5 ( ed)10.6 (.)-6.7 ( P)2 (hi)2.7 (l)2.6 (adel)2.6 (phi)2.7 (a:)-6.6 ( Li)2.7 (ppi)2.6 (nc)-2 (ot)-6.6 (t)4.2 ( )22.2 (W)-36.3 (i)13.5 (l)2.6 (l)2.6 (i)2.6 (am)-6 (s)-2 ( &)12.9 ( )]TJ 0 -1.152 Td [(W)-25.4 (i)13.5 (l)13.5 (k)-12.9 (i)2.6 (ns)-2 (;)4.2 ( 2005:)-6.6 (967)]TJ 0 Tc 0 Tw 7.87 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td (988.)Tj 0 Tc 0 Tw 1.935 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -10.141 -2.141 Td [(416.)-6.7 ( )11.3 (G)-6.6 (a)10.5 (g)-11.2 (el)2.6 ( R)2.6 (F,)4.2 ( C)2.7 (ot)-6.6 (e)10.5 ( G)4.3 (J)-2 (.)4.3 ( P)2 (at)-6.7 (ho)10.5 (g)-11.2 (enes)-2 (i)]TJ 16.793 0 Td [(s)8.9 ( o)10.5 (f)-6.6 ( m)-6 (edul)2.6 (l)13.5 (ar)-5.9 (y)8.8 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-6 (a.)4.3 ( I)-6.6 (n)10.5 (:)-6.6 ( )]TJ -16.793 -1.141 Td [(J)-2 (A)2 ( F,)4.2 ( ed.)4.3 ( )11.3 (T)-10.6 (hy)8.9 (r)-5.9 (oi)2.6 (d C)2.6 (anc)-2 (er)4.9 (.)-6.6 ( B)2 (os)8.9 (t)-6.6 (on/)-6.6 (D)2.6 (or)-6 (d)10.6 (r)-6 (ec)-2 (h)10.6 (t)-6.6 (/)-6.7 (Lond)10.5 (on:)-6.6 ( K)2 (l)2.6 (uw)13.5 (er)-6 ( A)2 (c)-2 (adem)-5.9 (i)2.6 (c)-2 (;)4.3 ( )]TJ 0.002 Tw 0 -1.152 Td [(1998:)-6.6 (85)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 3.946 0 Td [(103)10.5 (.)]TJ 0 Tc 0 Tw 1.924 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -5.87 -2.141 Td [(417.)-6.7 ( )11.3 (G)-6.6 (er)4.9 (t)-6.6 (ner)4.9 ( M)15.8 (E)1.9 (,)-6.6 ( K)2 (ebebew)13.5 ( E)2 (.)-6.6 ( M)15.7 (ul)2.6 (t)-6.6 (i)2.6 (p)-11.2 (l)2.6 (e endoc)-2 (r)-6 (i)2.6 (ne neopl)2.6 (as)-2 (i)2.6 (a t)-6.7 (y)8.9 (pe 2.)4.2 ( C)2.7 (ur)4.9 (r)-5.9 ( )]TJ 0 -1.141 Td [(T)-10.6 (r)-5.9 (e)10.5 (at)4.3 ( O)-6.6 (p)10.5 (t)-6.6 (i)2.6 (ons)-2 ( )11.3 (O)-6.6 (nc)-1.9 (ol)2.6 ( 200)10.5 (4;)-6.6 (5:)-6.6 (315)]TJ 0 Tc 0 Tw 14.185 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(325.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.522 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.7 (/)4.3 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (15233908)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 193.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 191.28 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 169.68 Tm [(418.)-6.7 ( R)2.7 (aue F)11.2 (,)4.2 ( Fr)-6 (an)10.6 (k)]TJ 0 Tc 0 Tw 8.587 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(R)2.6 (au)10.5 (e K)2 (.)-6.6 ( M)15.8 (ul)2.6 (t)-6.6 (i)2.6 (pl)2.6 (e endoc)-1.9 (r)-6 (i)2.6 (ne n)10.5 (eopl)2.6 (as)-2 (i)2.6 (a t)-6.6 (y)8.9 (pe 2:)-6.6 ( 2007)10.5 ( )]TJ -8.924 -1.152 Td [(updat)-6.6 (e.)4.2 ( H)2.6 (or)4.9 (m)-6 ( R)2.6 (es)8.9 ( 2007;)4.2 (68 S)2 (uppl)2.6 ( 5:)-6.6 (101)]TJ 0 Tc 0 Tw 17.565 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(104.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -17.902 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (18174721)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 144.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 142.32 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 120.72 Tm [(419.)-6.7 ( M)15.8 (oer)-5.9 (s)-2 ( A)1.9 (M)15.8 (,)-6.6 ( Lands)-2 (v)8.9 (at)-6.7 (er)4.9 ( R)2.6 (M)15.8 (,)-6.6 ( S)1.9 (c)-2 (haap C)2.6 (,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( )11.3 (Fam)-5.9 (i)2.6 (l)2.6 (i)2.6 (al)2.7 ( m)-6 (edul)2.7 (l)2.6 (ar)-5.9 (y)8.8 ( )]TJ 0 -1.152 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a:)4.3 ( not)4.3 ( a )11.3 (di)2.6 (s)-2 (t)-6.6 (i)2.6 (nc)-2 (t)-6.6 ( en)10.5 (t)-6.6 (i)2.6 (t)-6.6 (y)8.8 (? G)-6.6 (eno)10.5 (t)-6.6 (y)8.9 (pe)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 22.163 0 Td [(phenot)-6.6 (y)8.8 (pe c)-2 (or)4.9 (r)-6 (el)2.6 (at)-6.6 (i)2.7 (on i)2.6 (n)10.5 ( )]TJ -22.163 -1.141 Td [(a l)2.7 (ar)4.9 (g)-11.2 (e )11.2 (f)-6.6 (am)-6 (i)2.6 (l)2.6 (y)8.9 (.)-6.6 ( A)2 (m)4.9 ( J)8.8 ( M)15.8 (ed)-11.2 ( 1996;)-6.6 (101)10.5 (:)-6.6 (635)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 17.685 0 Td [(641)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e)]TJ 0 Tc 0 Tw ( )Tj -0.006 Tc 0.006 Tw 6.522 0 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw -24.207 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9003111)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 82.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 80.64 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 59.04 Tm [(420.)-6.7 ( S)2 (aad)10.5 ( M)15.8 (F,)-6.6 ( O)-6.6 (r)-6 (donez)8.8 ( )11.3 (N)2.6 (G)-6.6 (,)4.3 ( R)2.6 (as)-2 (hi)2.6 (d R)2.6 (K)2 (,)-6.6 ( e)10.5 (t)4.3 ( al)2.6 (.)-6.6 ( M)15.8 (edul)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( )0.5 (c)-2.1 (ar)-6 (c)-2 (i)2.7 (nom)-6 (a o)10.5 (f)-6.6 ( )11.2 (t)-6.6 (h)10.6 (e )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d.)-6.6 ( A)1.9 ( s)8.9 (t)-6.6 (udy)8.9 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.5 ( c)-2 (l)2.7 (i)2.5 (ni)2.6 (c)-2 (al)2.6 ( )11.3 (f)-17.5 (eat)-6.6 (u)10.5 (r)-6 (es)-2 ( and)10.5 ( pr)-6 (o)10.5 (g)-11.2 (n)10.5 (os)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (f)-6.6 (ac)-2 (t)-6.6 (o)10.5 (r)-5.9 (s)-2 ( i)2.6 (n)10.5 ( 161 )]TJ EMC ET endstream endobj 1087 0 obj 27730 endobj %% Contents for page 128 %% Original object ID: 257 0 1088 0 obj << /Length 1089 0 R >> stream Q q BT /Xi126 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1089 0 obj 246 endobj %% Original object ID: 11914 0 1090 0 obj [ 3064 0 R 3065 0 R 3066 0 R 3067 0 R 3068 0 R 3069 0 R 3070 0 R 3071 0 R 3072 0 R 3073 0 R 3074 0 R 3075 0 R 3076 0 R 3077 0 R 3078 0 R ] endobj %% Contents for page 129 %% Original object ID: 258 0 1091 0 obj << /Length 1092 0 R >> stream q endstream endobj 1092 0 obj 2 endobj %% Contents for page 129 %% Original object ID: 11915 0 1093 0 obj << /Length 1094 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (66)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(pat)-6.6 (i)2.6 (e)]TJ 0.007 Tw [(nt)-6.6 (s)-2 (.)4.3 ( M)15.7 (edi)2.6 (c)-2 (i)2.6 (ne \()-6 (B)2 (al)2.6 (t)-6.6 (i)2.6 (m)-5.9 (or)-6 (e)10.5 (\))-5.9 ( 1984)10.5 (;)-6.6 (63:)-6.6 (319)]TJ 0 Tc 0 Tw 19 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(342.)4.2 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -19.337 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (6503683)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 499.2 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 477.6 Tm [(421.)-6.7 ( V)2 (i)2.6 (t)-6.6 (al)2.6 (e )11.3 (G)4.2 (,)-6.6 ( )11.3 (T)-10.6 (a)10.6 (g)-11.3 (l)2.7 (i)2.6 (a)10.5 (f)-17.5 (er)4.9 (r)-6 (i)2.6 ( )11.3 (P)2 (,)-6.6 ( C)2.7 (ar)-5.9 (a)10.5 (g)-11.2 (l)2.6 (i)2.6 (a M)15.8 (,)-6.6 ( et)4.2 ( al)2.6 (.)4.2 ( S)2 (l)2.6 (ow)13.4 ( r)-5.9 (el)2.6 (eas)-2 (e l)2.6 (anr)-5.9 (eot)-6.6 (i)2.6 (de i)2.6 (n )]TJ 0 -1.141 Td [(c)-2 (om)-6 (bi)2.7 (nat)-6.6 (i)2.6 (on w)13.4 (i)2.7 (t)-6.7 (h i)2.6 (nt)]TJ 0.002 Tw 8.761 0 Td [(er)4.9 (f)-6.6 (er)4.9 (on)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 3.489 0 Td [(al)2.6 (pha2b i)2.6 (n t)-6.6 (he)10.6 ( )11.2 (t)-6.6 (r)-5.9 (ea)10.5 (t)-6.6 (m)4.9 (ent)-6.7 ( o)10.5 (f)-6.6 ( )0.5 (s)-2 (y)8.8 (m)-5.9 (p)10.5 (t)-6.6 (om)-5.9 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( )]TJ -12.25 -1.152 Td [(adv)8.9 (anc)-2 (ed m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.7 (nom)-6 (a)10.5 (.)-6.6 ( )11.3 (J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (n)10.5 (doc)-2 (r)-6 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.7 (ab )]TJ 0.002 Tw 0 -1.141 Td [(2000;)-6.6 (85:)-6.6 (983)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(988.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (10720027)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 426.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 424.92 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 403.32 Tm [(422.)-6.7 ( P)2 (ac)-2 (i)2.6 (n)]TJ [(i)2.6 ( F,)4.3 ( Fon)10.6 (t)-6.6 (anel)2.6 (l)2.6 (i)2.7 ( M)15.8 (,)-6.6 ( Fug)-11.2 (az)8.9 (z)8.9 (ol)2.6 (a L,)-6.6 ( et)-6.6 ( al)13.5 (.)-6.6 ( R)2.6 (o)10.5 (ut)-6.6 (i)2.6 (ne m)-6 (ea)10.5 (s)-2 (ur)-6 (e)10.5 (m)-5.9 (ent)4.2 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.141 Td [(s)-2 (er)-6 (um)5 ( c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.7 (n i)2.6 (n nodul)13.5 (ar)-6 ( )11.3 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d di)2.6 (s)-2 (eas)-2 (es)-2 ( al)2.6 (l)2.6 (ow)2.6 (s)-2 ( t)-6.6 (he)10.5 ( pr)-6 (eope)10.5 (r)-6 (at)-6.6 (i)2.6 (v)8.8 (e )]TJ 0 -1.152 Td [(di)2.6 (ag)-11.2 (nos)-2 (i)2.6 (s)-2 ( o)10.5 (f)-6.6 ( uns)-2 (u)10.6 (s)-2 (pec)-2 (t)-6.6 (e)10.5 (d s)-2 (por)-5.9 (adi)2.6 (c)8.9 ( m)-6 (edul)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (a.)4.3 ( J)8.8 ( C)2.6 (l)2.6 (i)2.7 (n )]TJ 0 -1.141 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 1994;)-6.6 (7)10.5 (8:)-6.6 (826)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.913 0 Td [(829)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -13.913 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8157706)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 350.76 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 329.16 Tm [(423.)-6.7 ( N)2.7 (i)2.6 (c)-2 (c)-2 (ol)2.6 (i)2.7 ( P)2 (,)4.2 ( )22.2 (W)-36.3 (i)13.5 (on)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.261 0 Td [(B)2 (a)10.5 (r)4.9 (bot)-6.6 ( N)2.6 (,)4.3 ( C)2.6 (ar)-5.9 (on)10.5 ( P)2 (,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( )11.3 (I)-6.6 (n)10.5 (t)4.3 (er)-5.9 (es)-2 (t)4.3 ( o)10.5 (f)-6.6 ( r)-6 (ou)10.5 (t)-6.6 (i)2.6 (ne )]TJ -9.261 -1.152 Td [(m)-6 (eas)-1.9 (ur)-5.9 (e)10.5 (m)-6 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( s)-2 (e)10.5 (r)-5.9 (um)4.9 ( c)8.9 (al)2.7 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n:)-6.6 ( s)-2 (t)-6.6 (udy)8.9 ( i)2.6 (n a)10.6 ( l)2.6 (ar)5 (g)-11.3 (e)10.6 ( s)-2 (er)-5.9 (i)2.5 (es)8.9 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (i)2.6 (z)8.9 (ed pat)-6.6 (i)2.6 (ent)4.3 (s)-2 (.)-6.6 ( )11.2 (T)-10.5 (he)10.5 ( Fr)]TJ 14.804 0 Td [(enc)-2 (h)10.5 ( M)15.8 (edul)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( )-10.5 (S)1.9 (t)-6.6 (udy)8.9 ( G)-6.6 (r)-6 (oup)10.6 (.)-6.6 ( )11.2 (J)-2 ( C)2.6 (l)2.7 (i)2.6 (n )]TJ -14.804 -1.152 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 1997;)-6.6 (8)10.5 (2:)-6.6 (338)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.913 0 Td [(341)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -13.913 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9024213)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 278.52 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 276.48 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 254.88 Tm [(424.)-6.7 ( )11.3 (O)-6.6 (z)8.9 (g)-11.2 (en)10.5 ( A)2 (G)4.2 (,)-6.5 ( H)2.6 (a)10.5 (m)-6 (ul)2.6 (u F,)4.3 ( B)2 (ay)8.9 (r)-6 (ak)-2 (t)-6.6 (ar)4.9 ( F,)4.3 ( et)4.3 ( al)2.6 (.)4.2 ( E)2 (v)8.9 (al)2.6 (uat)-6.6 (i)2.6 (on o)10.6 (f)-17.5 ( )11.3 (r)-6 (ou)10.6 (t)-6.6 (i)2.6 (ne bas)]TJ -0.005 Tc 0.005 Tw 31.413 0 Td [(a)-3.3 (l )]TJ -0.002 Tc 0.007 Tw -31.413 -1.152 Td [(s)-2 (er)-6 (um)5 ( c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.7 (n )11.3 (m)-6 (eas)-2 (ur)4.9 (em)-5.9 (ent)4.2 ( )11.3 (f)-17.5 (o)10.6 (r)-6 ( ea)10.6 (r)-6 (l)2.6 (y)8.9 ( di)2.6 (ag)-11.2 (nos)-2 (i)13.5 (s)-2 ( o)10.5 (f)-6.6 ( m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( i)2.6 (n s)-2 (ev)8.9 (en hund)10.5 (r)-5.9 (ed s)-2 (ev)8.9 (ent)-6.6 (y)]TJ 0 Tc 0 Tw 16.228 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(t)-6.6 (h)10.5 (r)-5.9 (ee pa)10.5 (t)-6.6 (i)2.6 (ent)4.3 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h nodul)2.7 (ar)-5.9 ( )11.2 (g)-11.2 (oi)2.6 (t)-6.6 (e)10.5 (r)-6 (.)4.3 ( )]TJ -16.565 -1.141 Td [(T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d 1999;)-6.6 (9)10.6 (:)-6.7 (579)]TJ 0 Tc 0 Tw 8.587 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(582.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (ab)-11.3 (l)2.7 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -8.924 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (10411120)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 204.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 202.2 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 180.6 Tm [(425.)-6.7 ( H)2.7 (or)-5.9 (v)8.8 (i)2.6 (t)-6.6 ( P)2 (K)1.9 (,)4.3 ( )11.3 (G)-6.6 (a)10.5 (g)-11.2 (el)2.6 ( R)13.5 (F.)-6.6 ( )11.3 (T)-10.6 (he)10.5 ( )11.3 (g)-11.3 (oi)2.6 (t)-6.6 (r)-6 (ous)8.9 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 ( w)13.5 (i)2.6 (t)-6.6 (h an el)2.6 (ev)8.9 (at)-6.6 (ed s)-2 (e)10.6 (r)-6 (u)10.5 (m)-5.9 ( )]TJ -0.005 Tc 0.005 Tw 0 -1.141 Td [(c)-5 (a)-3.4 (lc)-5 (it)-9.6 (o)-3.3 (n)-3.4 (in)]TJ 0.004 Tc -0.004 Tw 4.152 0 Td (--)Tj -0.002 Tc 0.007 Tw [(w)13.5 (hat)-6.6 ( t)-6.7 (o)10.6 ( do? J)8.9 ( )11.3 (C)2.6 (l)2.6 (i)2.6 (n E)2 (ndoc)-2 (r)-6 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.7 (ab 1997;)-6.6 (82:)-6.6 (335)]TJ 0 Tc 0 Tw 22.435 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(337.)4.2 ( )]TJ 0.007 Tw -26.924 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.013 Tc 0.013 Tw [(ht)-17.7 (t)]TJ -0.002 Tc 0.002 Tw 6.826 0 Td [(p)10.5 (:)-6.6 (/)4.3 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.7 (pub)10.5 (m)-6 (ed)10.5 (/)-6.6 (9024212)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 309.12 155.28 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 153.24 222.48 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 131.64 Tm [(426.)-6.7 ( H)2.7 (oda)10.5 (k)-2 ( S)1.9 (P)2 (,)-6.6 ( B)1.9 (u)10.6 (r)-6 (m)-5.9 (an)10.5 ( )11.3 (K)2 (D)2.6 (.)-6.6 ( )11.2 (T)-10.5 (he c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n)10.6 ( c)-2 (onun)10.6 (dr)-5.9 (um)]TJ 0.004 Tc -0.004 Tw 24.37 0 Td (--)Tj 0.005 Tc -0.011 Tw [(i)9.6 (s)5 ( )-10.6 (i)20.5 (t ti)9.7 (m)1 (e)6.7 ( fo)6.7 (r)11.9 ( )]TJ -0.002 Tc 0.007 Tw -24.37 -1.141 Td [(r)-6 (out)-6.6 (i)2.7 (ne )11.2 (m)-5.9 (eas)-2 (u)10.5 (r)-6 (em)-6 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (s)-2 (er)-5.9 (um)4.9 ( c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n i)2.6 (n pa)10.5 (t)-6.6 (i)2.6 (e)10.6 (nt)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d nodul)2.6 (es)-2 (?)10.5 ( )]TJ 0 -1.152 Td [(J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.7 (nol)2.6 ( M)15.7 (et)-6.6 (ab 2004;)-6.6 (89:)-6.6 (511)]TJ 0 Tc 0 Tw 16.348 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(514.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.7 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -16.685 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (14764754)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 93.72 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 91.68 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 70.08 Tm [(427.)-6.7 ( P)2 (api)2.6 ( )11.3 (G)-6.6 (,)4.2 ( C)2.7 (or)-6 (s)-1.9 (el)2.6 (l)2.6 (o S)12.8 (M)15.8 (,)-6.6 ( C)2.6 (i)2.6 (oni)2.6 ( K)2 (,)-6.7 ( et)-6.6 ( al)2.6 (.)4.3 ( V)2 (al)2.6 (ue o)10.5 (f)-6.5 ( )11.2 (r)-5.9 (out)-6.6 (i)2.6 (ne )11.2 (m)-5.9 (eas)-2 (u)10.5 (r)-5.9 (em)-5.9 (en)10.5 (t)-6.6 ( o)10.5 (f)4.3 ( )]TJ 0 -1.141 Td [(s)-2 (er)-6 (um)5 ( c)-2 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.7 (n c)-2 (on)10.6 (c)-2 (ent)4.2 (r)-5.9 (at)-6.6 (i)2.6 (ons)-2.1 ( )0.5 (i)2.6 (n)10.5 ( pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (i)2.6 (t)-6.6 (h n)10.5 (odul)2.6 (ar)-5.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d di)2.6 (s)-2 (eas)-2 (e)10.5 (:)-6.6 ( A)12.9 ( )]TJ 34.554 41.348 Td [(m)-6 (ul)2.6 (t)-6.6 (i)2.6 (c)-2 (ent)-6.6 (e)10.5 (r)-5.9 ( s)8.8 (t)-6.6 (udy)8.9 (.)-6.6 ( J)]TJ 0 Tc 0 Tw 8.587 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(E)2 (nd)10.5 (oc)-2 (r)-6 (i)2.7 (nol)2.7 ( I)-6.6 (nv)8.9 (es)-2 (t)-6.6 ( 2006)10.5 (;)-6.6 (29)10.6 (:)-6.6 (4)10.5 (27)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.783 0 Td [(437.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.652 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.7 (/)4.3 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (16794366)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 499.2 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 477.6 Tm [(428.)-6.7 ( K)2 (ouv)8.9 (ar)-5.9 (a)10.5 (k)-12.9 (i)2.7 ( M)15.8 (A)2 (,)-6.6 ( S)1.9 (hapi)2.6 (r)-5.9 (o S)2 (E)1.9 (,)-6.6 ( P)2 (e)10.5 (r)-6 (r)-5.9 (i)2.6 (er)4.9 ( )0.5 (N)2.5 (D)2.7 (,)4.2 ( et)4.2 ( al)2.6 (.)-6.6 ( R)2.6 (E)12.8 (T)-10.6 ( )0.5 (p)10.5 (r)-6 (ot)-6.6 (o)]TJ 0 Tc 0 Tw 26.815 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(onc)-2 (o)10.5 (g)-11.2 (ene)10.6 (:)-6.7 ( a)10.6 ( )]TJ -27.152 -1.141 Td [(r)-6 (ev)8.9 (i)2.6 (e)-11.2 (w)13.5 ( and updat)-6.6 (e o)10.6 (f)-6.6 ( )11.2 (g)-11.2 (e)10.5 (not)-6.6 (y)8.9 (pe)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.967 0 Td [(phenot)-6.6 (y)8.8 (pe c)-2 (or)4.9 (r)-6 (el)2.6 (at)-6.6 (i)2.7 (ons)-2 ( i)2.6 (n he)10.5 (r)-6 (edi)2.6 (t)-6.6 (ar)-6 (y)8.9 ( )]TJ -13.967 -1.152 Td [(m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 ( and as)-2 (s)-2.1 (o)10.6 (c)-2 (i)2.6 (at)-6.6 (ed endo)10.5 (c)-2 (r)-5.9 (i)2.6 (n)10.5 (e t)-6.6 (u)10.6 (m)-6 (or)-5.9 (s)8.9 (.)-6.6 ( )11.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0.002 Tw 0 -1.141 Td [(2005;)-6.6 (15:)-6.6 (531)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(544.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (16029119)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 426.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 424.92 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 403.32 Tm [(429.)-6.7 ( )33.1 (W)-36.3 (o)10.5 (hl)2.6 (l)2.6 (k)-2 ( N)2.6 (,)-6.6 ( C)2.6 (o)10.5 (t)-6.6 (e )11.2 (G)-6.6 (J)8.9 (,)-6.6 ( )11.3 (B)1.9 (ug)-11.3 (al)2.6 (ho M)4.9 (M)15.8 (,)-6.6 ( et)-6.7 ( )11.3 (al)2.6 (.)-6.6 ( R)2.6 (el)2.6 (e)10.6 (v)8.8 (anc)-2 (e of)-6.6 ( R)2.6 (E)12.9 (T)-10.6 ( p)10.5 (r)-5.9 (ot)-6.6 (o)]TJ 0 Tc 0 Tw 30.185 0 Td (-)Tj -0.002 Tc 0.007 Tw -30.185 -1.141 Td [(onc)-2 (og)-11.2 (ene)10.6 ( m)-6 (u)10.5 (t)-6.6 (a)10.5 (t)-6.5 (i)2.6 (ons)-2 ( i)2.6 (n s)8.9 (por)-6 (adi)2.5 (c)-2 ( m)5 (edul)2.6 (l)2.7 (ar)-5.9 (y)8.8 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (no)10.6 (m)-6 (a.)4.2 ( J)-2 ( C)2.6 (l)2.6 (i)2.6 (n )]TJ 0 -1.152 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 1996;)-6.6 (8)10.6 (1:)-6.6 (3740)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.467 0 Td [(3745)10.5 (.)-6.6 ( A)1.9 (v)]TJ 3.924 0 Td [(ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -18.391 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8855832)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 365.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 363.36 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 341.76 Tm [(430.)-6.7 ( E)2 (l)2.6 (i)2.6 (s)-2 (ei)2.6 ( R)2.6 (,)-6.6 ( R)2.6 (o)10.5 (m)-5.9 (ei)2.6 ( C)2.6 (,)4.3 ( )11.3 (C)2.6 (os)-2 (c)-2 (i)2.6 ( B)2 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( R)2.6 (E)12.9 (T)-10.6 ( )11.3 (g)-11.3 (ene)10.6 (t)-6.7 (i)2.7 (c)-2 ( s)-2 (c)8.8 (r)-5.9 (eeni)2.7 (ng )0.5 (i)2.5 (n pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( )]TJ 0 -1.141 Td [(w)2.6 (i)2.6 (t)-6.6 (h m)-6 (edul)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.5 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (nc)-2 (er)-5.9 ( and)10.5 ( t)-6.6 (hei)2.6 (r)4.9 ( r)-5.9 (el)2.6 (a)10.6 (t)-6.6 (i)2.6 (v)8.8 (es)-2 (:)-6.6 ( )11.3 (ex)8.9 (per)-6 (i)2.6 (enc)-2.1 (e w)2.6 (i)2.6 (t)-6.6 (h )]TJ 0.002 Tw (807 )Tj 0.007 Tw 0 -1.152 Td [(i)2.6 (ndi)-8.2 (v)8.8 (i)2.6 (dual)2.6 (s)-2 ( at)-6.6 ( one c)-2 (en)10.6 (t)-6.6 (er)4.9 (.)4.3 ( J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.6 (nol)2.7 ( M)15.8 (et)-6.6 (ab )11.3 (2007;)-6.6 (92:)-6.6 (4725)]TJ 0 Tc 0 Tw 28.196 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(4729.)4.3 ( )]TJ 0.007 Tw -28.533 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (17895320)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 303.84 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 301.8 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.005 Tc 0.01 Tw 11.04 -0 0 11.04 405 280.2 Tm [(4)-3.3 (3)-3.4 (1)-3.3 (.)-9.7 ( E)-1 (lis)-5 (e)-3.4 (i R,)-9.6 ( A)-1.1 (le)-3.3 (v)5.8 (iz)5.9 (a)-3.3 (k)-15.9 (i M)12.7 (,)-9.6 ( Co)-3.3 (n)-3.4 (t)-9.6 (e)]TJ 0 Tc 0 Tw 14.402 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(D)2.6 (ev)8.8 (ol)-8.3 (x)8.9 ( B)1.9 (,)-6.6 ( et)4.3 ( al)2.6 (.)4.3 ( 2012 E)1.9 (ur)-6 (op)10.5 (ea)]TJ -0.004 Tw [(n t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0.007 Tw -14.739 -1.152 Td [(as)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (i)2.6 (on )11.3 (g)-11.3 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )11.3 (g)-11.3 (ene)10.6 (t)-6.6 (i)2.6 (c)-2 ( t)-6.7 (e)10.6 (s)-2 (t)-6.6 (i)2.6 (n)10.5 (g)-11.2 ( and)10.5 ( i)2.6 (t)-6.6 (s)8.9 ( c)8.8 (l)2.7 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( c)-2 (ons)-2 (eq)-11.2 (uenc)-2 (es)8.9 ( i)2.6 (n )]TJ 0 -1.141 Td [(m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (.)-6.6 ( E)2 (ur)5 ( )11.2 (T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d J)-2 ( 2)10.6 (013;)-6.6 (1)10.5 (:)-6.6 (2)10.6 (16)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 22.935 0 Td [(231.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.935 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24783)]TJ (025)Tj EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 242.16 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 240.12 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 218.52 Tm [(432.)-6.7 ( R)2.7 (os)-2 (en)10.5 (t)-6.6 (hal)2.6 ( M)15.8 (S)1.9 (,)-6.6 ( D)2.6 (i)2.6 (ek)-2 (em)-5.9 (a D)2.7 (S)1.9 (.)4.3 ( P)1.9 (edi)2.6 (at)-6.6 (r)-6 (i)2.6 (c)8.9 ( et)-6.6 (hi)2.6 (c)-2 (s)8.9 ( )11.3 (g)-11.3 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (or)4.9 ( her)-6 (edi)2.6 (t)-6.7 (a)10.6 (r)-6 (y)8.9 ( )]TJ 0 -1.141 Td [(m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (.)-6.6 ( )11.3 (I)-6.6 (nt)4.3 ( J)-2 ( P)2 (edi)2.6 (at)4.3 (r)-6 ( E)2 (ndoc)8.8 (r)-5.9 (i)2.6 (nol)2.6 ( 2011;)-6.6 (2011)10.5 (:)-6.6 (847603.)4.2 ( )]TJ 0 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)]TJ 21.707 0 Td [(/)-6.6 (21436957)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 193.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 191.28 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 169.68 Tm [(433.)-6.7 ( )11.3 (G)-6.6 (r)-5.9 (ubbs)8.9 ( E)12.8 (G)-6.6 (,)4.3 ( R)2.6 (i)2.6 (c)-2 (h )11.3 (TA)2 (,)-6.7 ( )0.5 (N)13.4 (g)-11.2 ( C)13.5 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.5 (.)4.3 ( Lon)10.5 (g)]TJ 0 Tc 0 Tw 19.337 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(t)-6.6 (er)5 (m)4.9 ( out)-6.6 (c)-2 (o)10.5 (m)-6 (es)8.9 ( o)10.6 (f)-6.6 ( s)-2 (ur)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( )]TJ -19.663 -1.152 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( )11.3 (f)-6.6 (or)5 ( her)-5.9 (edi)13.5 (t)-6.6 (ar)-5.9 (y)8.8 ( )11.3 (pheoc)-2 (hr)-6 (om)-6 (o)10.5 (c)-2 (y)8.9 (t)-6.6 (om)-5.9 (a.)4.3 ( J)8.9 ( A)12.8 (m)-6 ( )0.5 (C)2.6 (ol)2.6 (l)2.6 ( S)2 (ur)4.9 (g )]TJ 0.002 Tw 0 -1.141 Td [(2013;)-6.6 (216:)-6.6 (280)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(289.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (go)]TJ [(v)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (23317575)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 131.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 129.6 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 108 Tm [(434.)-6.7 ( K)2 (ebebew)13.4 ( E)2 (,)-6.6 ( )11.3 (I)-6.6 (t)-6.7 (ua)10.5 (r)-5.9 (t)-6.6 (e)10.5 ( )11.3 (P)1.9 (H)2.6 (,)-6.6 ( S)2 (i)2.6 (per)-6 (s)-2 (t)-6.6 (ei)2.6 (n)10.5 ( A)2 (E)1.9 (,)-6.6 ( e)10.5 (t)-6.6 ( al)13.4 (.)-6.6 ( )11.3 (M)15.8 (edu)-11.2 (l)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (:)-6.6 ( c)-2 (l)2.6 (i)2.6 (ni)2.7 (c)-2 (al)2.6 ( c)-2 (har)-5.9 (a)10.5 (c)-2 (t)-6.6 (er)-5.9 (i)2.6 (s)8.9 (t)-6.7 (i)2.7 (c)-2 (s)-2 (,)4.2 ( t)4.3 (r)-6 (eat)4.3 (m)-5.9 (ent)4.2 (,)-6.6 ( p)10.5 (r)-5.9 (o)10.5 (g)-11.2 (nos)8.9 (t)-6.7 (i)2.7 (c)-2 ( )11.2 (f)-6.6 (ac)-2 (t)-6.6 (o)10.5 (r)-6 (s)-2 (,)4.3 ( and)10.5 ( a )]TJ 0 -1.152 Td [(c)-2 (om)-6 (par)-5.9 (i)2.6 (s)-2 (on)10.5 ( o)10.6 (f)-6.6 ( s)-2 (t)-6.6 (a)10.6 (g)-11.3 (i)2.7 (n)10.5 (g s)-2 (y)8.9 (s)-2 (t)-6.6 (em)5 (s)-2 (.)4.2 ( C)2.6 (anc)-2 (er)4.9 ( 2000;)-6.6 (88)10.5 (:)4.2 (1139)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 24.152 0 Td [(1148.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -24.152 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (10699905)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 70.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 68.04 228.72 0.84 re f EMC endstream endobj 1094 0 obj 27012 endobj %% Contents for page 129 %% Original object ID: 259 0 1095 0 obj << /Length 1096 0 R >> stream Q q BT /Xi127 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1096 0 obj 246 endobj %% Original object ID: 11932 0 1097 0 obj [ 3079 0 R 3080 0 R 3081 0 R 3082 0 R 3083 0 R 3084 0 R 3085 0 R 3086 0 R 3087 0 R 3088 0 R 3089 0 R 3090 0 R 3091 0 R 3092 0 R 3093 0 R ] endobj %% Contents for page 130 %% Original object ID: 260 0 1098 0 obj << /Length 1099 0 R >> stream q endstream endobj 1099 0 obj 2 endobj %% Contents for page 130 %% Original object ID: 11933 0 1100 0 obj << /Length 1101 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (67)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(435.)-6.7 ( S)2 (a)10.5 (m)-5.9 (aan N)2.6 (A)2 (,)4.3 ( S)1.9 (c)-2 (hul)2.6 (t)4.3 (z)8.9 ( P)1.9 (N)2.6 (,)-6.6 ( H)2.6 (i)2.6 (c)-2 (k)-12.8 (ey)8.9 ( R)2.6 (C)2.6 (.)4.3 ( M)15.8 (edul)-8.3 (l)-8.2 (ar)-5.9 (y)8.9 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (a:)4.3 ( )]TJ 0 -1.152 Td [(pr)-6 (o)10.5 (g)-11.2 (nos)-2 (i)2.6 (s)-2 ( o)10.6 (f)-6.7 ( )11.3 (f)-6.6 (am)-5.9 (i)2.6 (l)2.6 (i)2.6 (al)2.6 ( v)8.8 (er)-6 (s)-2 (us)-2 ( s)-2 (por)-6 (adi)2.7 (c)8.8 ( di)2.6 (s)-2 (eas)-2 (e and)10.5 ( )11.3 (t)-6.7 (he )11.3 (r)-5.9 (ol)2.6 (e o)10.5 (f)-6.6 ( r)-6 (adi)2.6 (o)10.6 (t)-6.6 (her)-6 (apy)8.9 (.)-6.6 ( )]TJ 0 -1.141 Td [(J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.7 (nol)2.6 ( M)15.7 (et)-6.6 (ab 1988;)-6.6 (67)]TJ 0.002 Tw [(:)-6.6 (801)]TJ 0 Tc 0 Tw 16.348 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(805.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.7 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -16.685 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (2901430)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 473.88 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 452.28 Tm [(436.)-6.7 ( )11.3 (O)-6.6 (')-6.6 (R)2.6 (i)2.6 (or)-5.9 (dai)2.6 (n D)2.7 (S)12.8 (,)-6.6 ( )11.2 (O)-6.6 (')-6.6 (B)12.8 (r)4.9 (i)2.6 (en T,)-6.6 ( )33 (W)-36.2 (e)10.5 (av)8.8 (er)-6 ( A)2 (L,)4.3 ( et)4.3 ( al)2.7 (.)4.2 ( )11.3 (M)15.8 (edu)-11.2 (l)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( i)2.6 (n m)-5.9 (ul)13.5 (t)-6.6 (i)2.6 (pl)2.6 (e en)10.5 (doc)-2 (r)-5.9 (i)2.6 (ne neopl)2.6 (as)-2 (i)2.6 (a t)-6.6 (y)8.9 (pes)-2 ( )11.3 (2A)2 ( and 2B)1.9 (.)4.3 ( S)1.9 (ur)]TJ -0.013 Tc 0.013 Tw 28.25 0 Td [(g)-22.2 (er)-17 (y)-2.1 ( )]TJ -0.002 Tc 0.002 Tw -28.25 -1.152 Td [(1994;)-6.6 (116:)-6.6 (1017)]TJ 0 Tc 0 Tw 6.652 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1023.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.989 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (7985081)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 412.32 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 390.72 Tm [(437.)-6.7 ( Li)2.6 (ppm)-5.9 (an)10.5 ( S)2 (M)15.8 (,)-6.6 ( M)15.8 (end)-11.2 (el)2.6 (s)-2 (ohn G)4.2 (,)-6.6 ( )11.3 (Tr)-6 (um)-6 (p)10.6 ( D)2.7 (L,)4.3 ( et)4.3 ( )11.3 (al)2.6 (.)-6.6 ( )11.3 (T)-10.6 (he p)10.5 (r)-5.9 (o)10.5 (g)-11.2 (nos)8.9 (t)-6.7 (i)2.7 (c)-2 ( and )]TJ 0 -1.152 Td [(bi)2.6 (ol)2.6 (og)-11.2 (i)2.6 (c)-2 (al)2.6 ( s)-2 (i)2.7 (g)-11.3 (ni)13.5 (f)-17.5 (i)2.6 (c)-2 (anc)-2 (e)10.5 ( o)10.6 (f)-6.7 ( )11.3 (c)-2 (el)2.7 (l)2.6 (ul)2.6 (ar)-6 ( het)-6.6 (er)-6 (o)10.6 (g)-11.3 (enei)]TJ 19.728 0 Td [(t)-6.6 (y)8.9 ( i)2.6 (n )11.3 (m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ -19.728 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (:)-6.6 ( a)10.5 ( s)-2 (t)-6.6 (udy)8.9 ( o)10.5 (f)-6.6 ( c)-2 (al)13.5 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (n,)-6.6 ( L)]TJ 0 Tc 0 Tw 15.011 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(dopa dec)-2 (a)10.5 (r)-5.9 (box)8.9 (y)8.8 (l)2.7 (as)-2 (e,)-6.7 ( and hi)2.6 (s)-2 (t)-6.7 (a)10.6 (m)-6 (i)2.6 (nas)-2 (e.)4.2 ( )]TJ -15.348 -1.141 Td [(J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.7 (nol)2.6 ( M)15.7 (et)-6.6 (ab 1982;)-6.6 (54:)-6.6 (233)]TJ 0 Tc 0 Tw 16.348 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(240.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.7 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -16.685 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (6798062)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 340.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 338.04 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn 11.04 -0 0 11.04 23.52 316.44 Tm (4)Tj -0.002 Tc 0.007 Tw 0.554 0 Td [(38.)-6.6 ( M)15.8 (endel)2.6 (s)-2 (ohn G)-6.6 (,)4.2 ( )22.1 (W)-36.2 (e)10.5 (l)13.5 (l)2.6 (s)-2 ( S)2 (A)1.9 (,)-6.6 ( J)8.9 (r)-6 (.)4.3 (,)-6.6 ( B)1.9 (ay)8.8 (l)2.7 (i)2.6 (n S)2 (B)1.9 (.)-6.6 ( R)2.6 (el)2.6 (at)-6.6 (i)2.7 (ons)-2 (hi)2.6 (p o)10.5 (f)-6.6 ( t)-6.6 (i)2.6 (s)-2 (s)-2 (ue)10.6 ( )]TJ -0.554 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (noem)-6 (b)10.5 (r)-5.9 (y)8.9 (oni)2.6 (c)-2 ( ant)-6.6 (i)2.6 (g)-11.2 (e)10.5 (n and c)-2 (al)2.5 (c)-2 (i)2.7 (t)-6.7 (oni)2.6 (n )11.3 (t)-6.6 (o)10.5 ( t)-6.6 (u)10.5 (m)-5.9 (or)4.9 ( v)8.9 (i)2.6 (r)-5.9 (ul)2.6 (enc)-2 (e i)2.6 (n m)-5.9 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( )]TJ 0 -1.152 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a.)4.3 ( A)2 (n i)2.6 (m)5 (m)-6 (unohi)2.6 (s)-2 (t)-6.6 (oc)-2 (he)10.5 (m)-5.9 (i)2.6 (c)-2 (al)2.6 ( s)8.8 (t)-6.6 (ud)10.5 (y)8.9 ( i)2.6 (n ear)-5.9 (l)2.6 (y)8.8 (,)-6.6 ( l)2.7 (oc)-2 (al)2.7 (i)-8.3 (z)8.9 (ed,)-6.6 ( and )]TJ 0 -1.141 Td [(v)8.9 (i)2.6 (r)-6 (ul)2.6 (ent)-6.6 ( di)2.7 (s)-2 (s)-2 (em)-6 (i)2.7 (nat)-6.7 (ed )11.2 (s)-2 (t)-6.6 (a)10.6 (g)-11.3 (es)8.8 ( o)10.6 (f)-6.6 ( di)2.6 (s)-2 (eas)-2 (e.)4.2 ( C)2.7 (an)]TJ [(c)-2 (er)4.9 ( 1)10.6 (984;)-6.6 (54:)-6.6 (657)]TJ 0 Tc 0 Tw 26.978 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(662.)4.2 ( )]TJ 0.007 Tw -27.315 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.7 (/)4.3 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (6378353)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 309.12 265.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 263.88 222.48 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 242.16 Tm [(439.)-6.7 ( D)2.7 (ot)4.3 (t)-6.6 (or)-5.9 (i)2.6 (ni)2.6 ( M)15.8 (E)2 (,)-6.6 ( A)1.9 (s)-2 (s)-2 (i)2.6 ( A)12.8 (,)-6.6 ( )0.5 (S)1.9 (i)2.6 (r)-6 (oni)2.6 ( M)15.8 (,)-6.7 ( et)4.3 ( al)2.6 (.)4.3 ( M)15.8 (ul)2.6 (t)-6.6 (i)-8.2 (v)8.8 (ar)-6 (i)-8.2 (at)-6.6 (e anal)2.6 (y)8.9 (s)-2 (i)2.6 (s)-2 ( o)10.5 (f)-17.5 ( )11.3 (pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( )]TJ 0 -1.141 Td [(w)2.6 (i)2.6 (t)-6.6 (h m)-6 (edul)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.5 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a.)4.3 ( P)1.9 (r)-5.9 (o)10.5 (g)-11.2 (no)]TJ 18.283 0 Td [(s)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (s)-2 (i)2.6 (g)-11.2 (n)10.5 (i)2.6 (f)-17.5 (i)2.6 (c)-2 (anc)-2 (e)10.6 ( and i)13.5 (m)-6 (pac)-2 (t)4.3 ( on )]TJ -18.283 -1.141 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( and pat)-6.6 (hol)2.6 (og)-11.2 (i)2.5 (c)8.9 ( v)8.9 (ar)-5.9 (i)2.6 (abl)2.6 (es)-2 (.)-6.6 ( C)2.6 (a)10.5 (nc)-2 (er)-6 ( )0.5 (1996)10.5 (;)-6.6 (77:)-6.6 (1556)]TJ 0 Tc 0 Tw 29.75 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(1565)10.5 (.)-6.6 ( )]TJ 0.007 Tw -30.087 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (8608543)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 309.12 204.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 202.2 222.48 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 180.6 Tm [(440.)-6.7 ( B)2 (y)8.9 (ar)-5.9 ( D)2.6 (P)1.9 (,)4.3 ( )11.3 (G)-6.6 (r)-6 (een)10.5 ( S)2 (B)1.9 (,)-6.6 ( D)2.7 (or)4.9 ( P)2 (,)4.2 ( et)]TJ 0 Tc 0 Tw 15.348 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(al)2.6 (.)4.2 ( A)2 ( pr)-5.9 (o)10.5 (g)-11.2 (n)10.5 (os)-2 (t)4.2 (i)2.6 (c)-2 ( i)2.6 (ndex)8.9 ( f)-17.5 (o)10.5 (r)-6 ( )11.3 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d )]TJ -15.63 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( A)12.8 ( s)-2 (t)-6.6 (udy)8.9 ( o)10.5 (f)-6.6 ( )11.2 (t)-6.6 (h)10.6 (e E)2 (.)4.2 (O)-6.6 (.)-6.6 (R)2.6 (.)4.3 (T.)-6.6 (C)2.6 (.)4.3 ( )11.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d C)2.6 (a)10.6 (nc)-2 (er)-6 ( C)2.6 (oope)10.5 (r)-6 (at)-6.6 (i)2.6 (v)8.9 (e G)4.3 (r)-6 (oup.)4.3 ( )]TJ 0 -1.152 Td [(E)2 (ur)-5.9 ( J)8.8 ( C)2.6 (anc)-2 (er)4.9 ( 1979;)-6.6 (15)10.5 (:)-6.6 (10)10.5 (33)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 12.522 0 Td [(1041.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -12.522 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (510341)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 240 142.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 140.64 216.481 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 23.52 119.04 Tm (44)Tj 0.007 Tw [(1.)-6.7 ( S)2 (z)8.9 (i)2.6 (nnai)2.7 ( G)-6.7 (,)4.3 ( M)15.8 (ei)2.7 (er)-6 ( C)2.6 (,)-6.6 ( )0.5 (K)1.9 (om)5 (m)-6 (i)2.6 (not)-6.6 (h P)12.8 (,)-6.6 ( Zu)10.5 (m)-5.9 (s)8.8 (t)-6.6 (e)10.5 (g)-11.2 ( )11.3 (U)24.3 (W)-36.2 (.)4.2 ( R)2.6 (ev)8.9 (i)2.6 (ew)13.5 ( of)-17.5 ( )11.3 (m)-6 (ul)2.7 (t)-6.7 (i)2.7 (pl)2.6 (e )]TJ 0 -1.152 Td [(endoc)-2 (r)-5.9 (i)2.6 (ne neopl)2.6 (as)-2 (i)2.7 (a t)-6.6 (y)8.9 (pe)10.5 ( 2A)1.9 ( i)2.7 (n c)-2 (hi)2.6 (l)2.6 (dr)-5.9 (en)10.6 (:)-6.7 ( )11.3 (t)-6.6 (her)-5.9 (apeu)10.5 (t)4.3 (i)2.6 (c)-2 ( r)-5.9 (es)-2 (ul)2.6 (t)-6.6 (s)8.8 ( o)10.6 (f)-6.7 ( ear)-5.9 (l)2.6 (y)8.9 ( )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( and p)10.6 (r)-6 (o)10.5 (g)-11.2 (n)10.5 (os)-2 (t)-6.6 (i)2.6 (c)-2 ( v)8.9 (al)2.6 (ue o)10.5 (f)-17.4 ( )11.2 (c)-2 (odon anal)13.5 (y)8.9 (s)-2 (i)2.6 (s)-2 (.)-6.6 ( P)1.9 (edi)2.6 (at)-6.6 (r)-6 (i)2.6 (c)-2 (s)-2 ( )]TJ 0.002 Tw 0 -1.141 Td [(2003;)-6.6 (111:)-6.6 (E)1.9 (132)]TJ 0 Tc 0 Tw 6.761 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(139.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -7.098 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (12563086)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 68.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 66.36 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(442.)-6.7 ( R)2.7 (o)10.5 (m)-6 (ei)2.6 ( C)2.6 (,)4.2 ( )0.5 (E)1.9 (l)2.6 (i)2.6 (s)-2 (ei)2.6 ( R)2.6 (,)-6.6 ( )11.3 (P)1.9 (i)2.6 (nc)-2 (her)-6 (a A)1.9 (,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( S)1.9 (o)10.5 (m)-5.9 (at)-6.6 (i)13.5 (c)-2 ( m)-5.9 (u)10.5 (t)-6.6 (at)-6.6 (i)2.6 (ons)8.9 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.5 ( r)-6 (e)10.5 (t)-6.6 ( )]TJ 0 -1.152 Td [(pr)-6 (ot)-6.6 (oonc)-2 (o)10.5 (g)-11.2 (ene)10.5 ( i)2.7 (n s)-2 (po)10.6 (r)-6 (ad)10.5 (i)2.6 (c)-2 ( m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)4.9 (c)-2 (i)2.6 (nom)-5.9 (a a)10.6 (r)-6 (e no)10.5 (t)-6.6 ( )11.3 (r)-6 (es)8.9 (t)-6.7 (r)-5.9 (i)2.6 (c)-2 (t)-6.6 (ed)10.5 ( )]TJ 0 -1.141 Td [(t)-6.6 (o ex)8.9 (on 16 and)10.5 ( ar)-5.9 (e)10.5 ( as)-2 (s)-2 (o)10.5 (c)-2 (i)2.6 (at)]TJ 12.25 0 Td [(ed w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (u)10.6 (m)-6 (or)5 ( r)-6 (ec)-1.9 (u)10.5 (r)-6 (r)-5.9 (e)10.5 (nc)-2.1 (e.)-6.6 ( J)8.8 ( C)2.7 (l)2.6 (i)2.6 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( )]TJ -12.25 -1.152 Td [(M)15.8 (et)-6.6 (ab 1996;)-6.6 (81:)-6.6 (1619)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.489 0 Td [(16)10.5 (22.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -9.489 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8636377)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 463.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 461.28 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 439.68 Tm [(443.)-6.7 ( E)2 (n)10.5 (g C)2.6 (,)-6.6 ( C)2.6 (l)2.6 (ay)8.9 (t)-6.6 (on D)2.6 (,)4.3 ( )11.3 (S)1.9 (c)-2 (hu)10.5 (f)-6.6 (f)-17.5 (enec)8.8 (k)-12.8 (e)10.5 (r)-6 ( )11.3 (I)4.3 (,)-6.6 ( e)10.6 (t)-6.6 ( al)2.6 (.)4.3 ( )11.3 (T)-10.6 (h)10.5 (e r)-6 (el)2.6 (at)-6.6 (i)2.6 (ons)-2 (hi)2.6 (p be)10.5 (t)-6.6 (w)13.5 (een )]TJ 0 -1.152 Td [(s)-2 (pec)-2 (i)13.5 (f)-17.5 (i)2.6 (c)-2 ( R)2.6 (E)2 (T p)10.5 (r)-5.9 (ot)-6.6 (o)]TJ 0 Tc 0 Tw 8.141 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(onc)-2 (o)10.5 (g)-11.2 (ene)10.6 ( m)-5.9 (u)10.5 (t)-6.6 (at)-6.6 (i)2.7 (ons)8.8 ( and di)2.6 (s)-2 (e)10.6 (as)-2 (e phenot)-6.6 (y)8.9 (pe i)2.6 (n )11.2 (m)-5.9 (ul)2.6 (t)-6.6 (i)2.6 (pl)2.6 (e )]TJ -8.478 -1.141 Td [(endoc)-2 (r)-5.9 (i)2.6 (ne neopl)2.6 (as)-2 (i)2.7 (a t)-6.6 (y)8.9 (pe)10.6 ( 2.)4.3 ( I)-6.7 (n)10.6 (t)-6.6 (er)-5.9 (na)10.5 (t)-6.6 (i)2.6 (onal)2.6 ( R)2.6 (E)2 (T m)-6 (u)10.5 (t)4.3 (at)-6.7 (i)2.7 (on c)-2 (ons)-2 (o)10.5 (r)-6 (t)-6.6 (i)2.6 (um)4.9 ( )]TJ 0 -1.141 Td [(anal)2.6 (y)8.8 (s)-2 (i)2.7 (s)-2.1 (.)-6.6 ( J)-1.9 (A)1.9 (M)4.9 (A)2 ( 1996;)-6.6 (27)10.5 (6:)-6.6 (1575)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.076 0 Td [(1579)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e a)]TJ -0.006 Tc 0.006 Tw [(t)-10.6 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw -14.076 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8918855)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 389.04 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 387 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 365.4 Tm [(444.)-6.7 ( )33.1 (W)-36.3 (el)2.7 (l)2.6 (s)8.8 ( S)2 (A)1.9 (,)-6.6 ( J)8.9 (r)-6 (.)4.3 (,)4.3 ( R)2.6 (obi)2.6 (ns)-2.1 (on B)1.9 (G)4.3 (,)-6.6 ( )11.2 (G)-6.6 (a)10.6 (g)-11.3 (el)2.6 ( R)2.6 (F)11.2 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.7 (.)4.2 ( V)2 (andet)-6.6 (ani)2.6 (b i)2.6 (n pa)10.6 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( )]TJ 0 -1.141 Td [(w)2.6 (i)2.6 (t)-6.6 (h l)2.6 (oc)-2 (al)2.6 (l)2.6 (y)8.9 ( ad)-11.2 (v)8.9 (anc)-2 (ed or)-5.9 ( )11.2 (m)-5.9 (et)-6.6 (as)8.9 (t)-6.7 (at)-6.6 (i)2.6 (c)8.9 ( m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.7 (hy)8.9 (r)4.9 (oi)2.7 (d c)-2 (anc)-2 (er)4.9 (:)-6.6 ( a)10.5 ( )]TJ 0 -1.152 Td [(r)-6 (andom)-6 (i)2.6 (z)8.9 (ed,)-6.6 ( d)]TJ 0.002 Tw [(oubl)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.098 0 Td [(bl)2.6 (i)2.6 (n)10.5 (d phas)-2 (e )11.2 (I)-6.6 (I)4.3 (I)-6.6 ( )11.2 (t)-6.6 (r)-5.9 (i)2.6 (al)2.7 (.)4.2 ( J)-2 ( C)2.6 (l)2.6 (i)2.6 (n )11.3 (O)4.2 (nc)-2 (ol)2.6 ( 2012;)-6.6 (30)10.5 (:)-6.6 (134)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 20.152 0 Td [(141)10.5 (.)-6.6 ( )]TJ 0.007 Tw -29.25 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (22025146)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 327.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 325.44 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 303.84 Tm [(445.)-6.7 ( )11.3 (T)-10.5 (ho)10.5 (r)-5.9 (nt)-6.6 (on)10.5 ( K)1.9 (,)4.3 ( K)2 (i)2.6 (m)-6 ( )11.3 (G)4.3 (,)-6.7 ( )11.3 (M)15.8 (aher)-6 ( V)2 (E)1.9 (,)-6.6 ( et)4.3 ( al)2.6 (.)-6.6 ( V)1.9 (ande)10.5 (t)4.3 (ani)2.6 (b )11.3 (f)-17.5 (or)4.9 ( t)-6.6 (he)10.5 ( t)4.3 (r)-5.9 (eat)4.2 (m)-5.9 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( )]TJ -0.011 Tc 0.011 Tw 0 -1.152 Td [(s)-11 (ym)-15 (p)-9.3 (t)]TJ -0.002 Tc 0.007 Tw 2.663 0 Td [(om)-6 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( o)10.5 (r)-5.9 ( p)10.5 (r)-5.9 (o)10.5 (g)-11.3 (r)-5.9 (es)-2.1 (s)8.9 (i)2.6 (v)8.9 (e m)-6 (edul)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)-6 ( i)2.6 (n pa)10.6 (t)-6.7 (i)2.7 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h )]TJ -2.663 -1.141 Td [(unr)-6 (es)-2 (ec)-2 (t)-6.7 (abl)2.6 (e)10.5 ( l)2.6 (oc)-1.9 (al)2.6 (l)2.6 (y)8.9 ( adv)-2 (anc)-2 (ed or)4.9 ( m)-6 (e)10.5 (t)-6.6 (as)8.9 (t)-6.6 (at)-6.6 (i)2.6 (c)8.9 ( di)2.6 (s)-2 (eas)-2 (e:)-6.6 ( U)13.5 (.)-6.6 (S)1.9 (.)-6.6 ( F)11.2 (ood and)10.6 ( D)2.6 (r)-6 (u)10.5 (g )]TJ 0 -1.141 Td [(A)2 (dm)-5.9 (i)2.6 (ni)2.6 (s)-2 (t)-6.6 (r)-5.9 (at)-6.6 (i)2.6 (on)10.5 ( dr)-5.9 (u)10.5 (g appr)4.9 (ov)8.9 (al)2.6 ( s)-2 (um)-6 (m)-5.9 (ar)-5.9 (y)8.8 (.)4.3 ( C)2.6 (l)2.6 (i)2.6 (n C)2.6 (anc)-2 (er)-5.9 ( R)2.6 (es)8.9 ( 2012;)-6.6 (18)10.5 (:)-6.6 (3722)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 0 -1.152 Td [(3730.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.3 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.7 (nc)-2 (bi)2.6 (.)-6.7 (nl)2.6 (m)-5.9 (.)-6.7 (ni)2.6 (h.)-6.6 (g)-11.3 (ov)8.9 (/)-6.7 (pu)10.5 (bm)-6 (ed/)-6.6 (22665903)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 727.32 253.2 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 498.72 251.16 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 229.56 Tm [(446.)-6.7 ( )11.3 (Tr)-5.9 (ay)8.9 (nor)-6 ( K)2 (.)4.2 ( )0.5 (C)2.6 (aboz)8.9 (ant)-6.6 (i)2.6 (ni)2.6 (b appr)-6 (ov)8.8 (ed )11.2 (f)-17.5 (o)10.6 (r)-6 ( adv)8.9 (anc)-2 (ed m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.141 Td [(c)-2 (anc)-2 (er)-6 (.)4.3 ( A)1.9 (m)4.9 ( J)8.9 ( H)2.6 (eal)2.6 (t)-6.6 (h S)1.9 (y)8.9 (s)-2 (t)-6.6 ( P)2 (har)4.9 (m)4.9 ( 2013;)-6.6 (70)10.6 (:)-6.7 (88.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 0 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (23292257)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 204.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 202.2 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 180.6 Tm [(447.)-6.7 ( E)2 (l)2.6 (i)2.6 (s)-2 (ei)2.6 ( R)2.6 (,)-6.6 ( S)1.9 (c)-2 (hl)2.6 (u)10.5 (m)-5.9 (ber)4.9 (g)-11.2 (e)10.5 (r)-6 ( )0.5 (M)15.7 (J)-2 (,)-6.6 ( M)15.8 (ul)2.6 (l)2.6 (er)-5.9 ( S)1.9 (P)2 (,)-6.6 ( et)4.3 ( al)2.6 (.)-6.6 ( )11.3 (C)2.6 (aboz)8.8 (ant)-6.6 (i)2.6 (ni)2.6 (b i)2.6 (n )]TJ 0 -1.141 Td [(pr)-6 (o)10.5 (g)-11.2 (r)-5.9 (es)-2 (s)-2 (i)2.6 (v)8.9 (e m)-5.9 (edul)2.7 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.6 (h)10.5 (y)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)-5.9 (.)4.2 ( J)-2 ( C)2.6 (l)2.6 (i)2.7 (n )11.3 (O)-6.6 (nc)8.9 (ol)2.7 ( 2013;)-6.6 (31:)-6.6 (3639)]TJ 0 Tc 0 Tw 28.587 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(3646.)4.3 ( )]TJ 0.007 Tw -28.924 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (24002501)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 155.28 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 153.24 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 131.64 Tm [(448.)-6.7 ( M)15.8 (ac)-2 (hens)-1.9 ( A)2 (,)4.3 ( D)2.6 (r)-6 (al)2.6 (l)2.6 (e )11.2 (H)2.6 (.)-6.6 ( )11.3 (G)-6.6 (enot)-6.6 (y)8.9 (pe)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 16.565 0 Td [(phenot)-6.6 (y)8.8 (pe bas)-2 (ed )-10.6 (s)-2 (ur)4.9 (g)-11.2 (i)2.6 (c)-2 (al)2.6 ( c)-2 (onc)-2 (ept)4.3 ( )-10.6 (o)10.5 (f)-6.6 ( )]TJ 0.007 Tw -16.565 -1.141 Td [(her)-6 (edi)2.6 (t)-6.6 (ar)-5.9 (y)8.8 ( )11.3 (m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.5 (.)-6.6 ( )33 (W)-36.2 (o)10.5 (r)-6 (l)2.7 (d)10.5 ( J)-2 ( S)12.8 (ur)4.9 (g)-11.3 ( 2007)10.5 (;)-6.6 (31:)-6.6 (957)]TJ 0 Tc 0 Tw 29.304 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(968.)4.2 ( )]TJ 0.007 Tw -29.641 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (17453286)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 106.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 104.28 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 82.68 Tm [(449.)-6.7 ( Lea)10.6 (r)-6 (oy)8.9 (d D)2.6 (L,)-6.7 ( )11.3 (G)-6.6 (os)-2 (nel)13.5 (l)2.6 ( J)-2 (,)-6.6 ( )0.5 (E)1.9 (l)2.6 (s)8.9 (t)-6.6 (on M)15.8 (S)1.9 (,)-6.6 ( et)4.2 ( al)2.6 (.)-6.6 ( E)1.9 (x)8.9 (per)-6 (i)2.7 (enc)-2 (e o)10.5 (f)-6.6 ( pr)-6 (ophy)8.8 (l)2.7 (ac)-2 (t)-6.6 (i)2.6 (c)-2 ( )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (dec)-2 (t)-6.6 (om)-6 (y)8.9 ( i)2.6 (n )11.3 (m)-5.9 (ul)2.6 (t)-6.6 (i)2.6 (pl)2.6 (e endoc)-2 (r)-6 (i)2.6 (ne neopl)2.6 (as)-2 (i)2.6 (a )11.3 (t)-6.6 (y)8.9 (pe 2A)2 ( )11.3 (k)-12.9 (i)2.6 (ndr)-6 (eds)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h R)2.6 (E)1.9 (T )]TJ 0 -1.141 Td [(c)-2 (odon 804 )11.2 (m)-5.9 (u)10.5 (t)-6.6 (at)-6.6 (i)2.6 (ons)-2 (.)4.2 ( C)2.6 (l)2.6 (i)2.6 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( \()4.9 (O)-6.6 (x)19.7 (f)-17.5 (\))5 ( 2005;)4.2 (63:)-6.6 (636)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 25.163 0 Td [(641)10.5 (.)-6.6 ( A)]TJ 2.88 0 Td [(v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -28.043 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (16343097)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 44.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 42.72 228.72 0.84 re f EMC endstream endobj 1101 0 obj 27770 endobj %% Contents for page 130 %% Original object ID: 261 0 1102 0 obj << /Length 1103 0 R >> stream Q q BT /Xi128 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1103 0 obj 246 endobj %% Original object ID: 11949 0 1104 0 obj [ 3094 0 R 3095 0 R 3096 0 R 3097 0 R 3098 0 R 3099 0 R 3100 0 R 3101 0 R 3102 0 R 3103 0 R 3104 0 R 3105 0 R 3106 0 R 3107 0 R 3108 0 R 3109 0 R ] endobj %% Contents for page 131 %% Original object ID: 262 0 1105 0 obj << /Length 1106 0 R >> stream q endstream endobj 1106 0 obj 2 endobj %% Contents for page 131 %% Original object ID: 11950 0 1107 0 obj << /Length 1108 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (68)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(450.)-6.7 ( R)2.7 (i)2.6 (c)-2 (h )11.3 (T)-10.6 (A)12.9 (,)-6.7 ( Fen)10.5 (g L,)4.3 ( B)12.8 (us)-2 (ai)2.6 (dy)8.9 ( N)2.7 (,)-6.7 ( et)-6.6 ( al)13.5 (.)-6.6 ( P)12.8 (r)-5.9 (ev)8.9 (al)2.6 (en)-11.2 (c)-2 (e by)8.9 ( ag)-11.2 (e)10.5 ( and)10.6 ( pr)-5.9 (edi)2.6 (c)-2 (t)-6.6 (o)10.5 (r)-6 (s)8.9 ( )]TJ 0 -1.152 Td [(o)10.5 (f)-17.5 ( )11.3 (m)-5.9 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)8.8 (er)-6 ( )0.5 (i)2.6 (n pa)10.6 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (i)2.6 (t)-6.6 (h l)2.6 (ow)13.5 (er)-6 ( r)-5.9 (i)2.6 (s)-2 (k)-12.9 ( )11.3 (ger)4.9 (m)-6 (l)2.6 (i)2.6 (ne )]TJ [(R)2.6 (E)1.9 (T pr)-6 (o)10.5 (t)-6.6 (o)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 0 -1.141 Td [(onc)-2 (og)-11.2 (ene)10.6 ( m)-6 (u)10.5 (t)-6.6 (a)10.5 (t)-6.5 (i)2.5 (ons)-2 (.)-6.7 ( )11.3 (T)-10.5 (h)10.5 (y)8.9 (r)-6 (oi)2.7 (d 2014;)-6.6 (24:)-6.6 (1096)]TJ 0 Tc 0 Tw 19.228 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1106)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -19.565 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24617864)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 473.88 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 452.28 Tm [(451.)-6.7 ( N)2.7 (i)2.6 (eder)-5.9 (l)2.6 (e B)12.8 (,)-6.5 ( S)1.9 (eba)10.5 (g )11.2 (F,)-6.7 ( )0.5 (B)1.9 (r)-6 (au)10.5 (c)8.9 (k)-12.9 (ho)10.5 (f)-6.6 (f)-6.6 ( M)15.8 (.)-6.6 ( )11.2 (T)-10.5 (i)2.6 (m)-6 (i)2.6 (n)10.6 (g )11.3 (and ex)8.9 (t)-6.7 (ent)-6.6 ( o)10.6 (f)-6.7 ( )11.3 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ -0.004 Tw 0 -1.141 Td [(s)-2 (ur)4.9 (g)-11.3 (er)-5.9 (y)8.8 ( f)-17.5 (o)10.5 (r)]TJ 0 Tc 0 Tw 4.772 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(g)-11.2 (ene)10.5 ( c)-2 (a)10.5 (r)-5.9 (r)-6 (i)2.6 (er)-6 (s)8.9 ( o)10.5 (f)-6.6 ( her)-5.9 (edi)2.6 (t)-6.6 (a)10.5 (r)-6 (y)8.9 ( C)2.6 ( c)-2 (el)2.6 (l)2.6 ( di)2.6 (s)-2 (e)10.6 (as)-2 (e)]TJ 0.004 Tc -0.004 Tw (--)Tj -0.002 Tc 0.007 Tw [(a)10.5 ( c)-2 (ons)-2 (ens)-2 (us)8.9 ( )]TJ -5.043 -1.152 Td [(s)-2 (t)-6.6 (at)-6.6 (e)10.6 (m)-6 (ent)4.3 ( o)10.5 (f)-6.6 ( )11.3 (t)-6.7 (he E)1.9 (ur)4.9 (ope)10.5 (an S)2 (oc)-2 (i)2.6 (et)-6.6 (y)8.8 ( o)10.6 (f)-6.6 ( E)1.9 (ndoc)-2 (r)-6 (i)2.6 (ne )11.3 (S)2 (ur)-5.9 (g)-11.3 (eon)10.6 (s)-2 ( )11.2 (\()-5.9 (E)1.9 (S)2 (E)2 (S)1.9 (\))-5.9 (.)4.2 ( )]TJ 0 -1.141 Td [(Lang)-11.3 (enbec)8.8 (k)-2 (s)-2 ( A)2 (r)4.9 (c)-2 (h S)2 (u)10.5 (r)4.9 (g)-11.2 ( )11.3 (2014;)-6.6 (399:)-6.6 (185)]TJ 0 Tc 0 Tw 17.011 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(197.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -17.348 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)6.6 (l)9.6 (m)1.1 (.n)]TJ -0.002 Tc 0.002 Tw 9.478 0 Td [(i)2.6 (h.)4.2 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24297502)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 401.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 399.72 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 378 Tm [(452.)-6.7 ( B)2 (r)-6 (andi)13.5 ( M)15.8 (L,)-6.6 ( G)-6.6 (a)10.5 (g)-11.2 (el)2.6 ( R)13.5 (F,)-6.6 ( )0.5 (A)1.9 (n)10.5 (g)-11.2 (el)2.6 (i)2.6 ( A)1.9 (,)4.3 ( et)4.3 ( al)2.7 (.)-6.6 ( )11.2 (G)-6.6 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( di)2.6 (a)10.5 (g)-11.2 (nos)-2 (i)2.7 (s)-2 ( a)10.5 (nd )]TJ 0 -1.141 Td [(t)-6.6 (her)-6 (apy)8.9 ( o)10.5 (f)-6.6 ( M)15.8 (E)2 (N)2.6 ( t)-6.6 (y)8.8 (pe 1 and )0.5 (t)-6.7 (y)8.9 (pe 2.)4.2 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.6 (nol)2.5 ( )0.5 (M)15.7 (et)-6.6 (ab 2001;)-6.6 (86:)-6.6 (5658)]TJ 0 Tc 0 Tw 32.304 0 Td (-)Tj -0.002 Tc 0.007 Tw -32.304 -1.141 Td [(5671.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw [(h)17.5 (ttp)17.5 (:)0.5 (/)11.2 (/)11.3 (w)9.6 (w)]TJ -0.002 Tc 0.002 Tw 12.402 0 Td [(w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)-6.6 (g)-11.2 (ov)8.9 (/)-6.6 (pu)10.6 (bm)-5.9 (ed/)-6.6 (11739416)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 345.84 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 117.24 350.76 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 329.16 Tm [(453.)-6.7 ( M)15.8 (ac)-2 (hens)-1.9 ( A)2 (,)4.3 ( N)2.6 (i)2.6 (c)-2 (c)-2 (ol)2.6 (i)]TJ 0 Tc 0 Tw 10.685 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(S)2 (i)2.6 (r)-6 (e P)1.9 (,)-6.6 ( H)2.6 (oe)10.5 (g)-11.2 (el)2.6 ( )11.3 (J)-2 (,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( E)12.9 (ar)-6 (l)2.7 (y)8.8 ( m)-5.9 (al)2.6 (i)2.6 (g)-11.2 (nant)4.2 ( )]TJ -11.022 -1.152 Td [(pr)-6 (o)10.5 (g)-11.2 (r)-5.9 (es)-2 (s)-2 (i)2.6 (on)10.5 ( o)10.5 (f)-6.6 ( her)-6 (edi)2.6 (t)-6.6 (a)10.5 (r)-6 (y)8.9 ( m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-6 (.)4.3 ( N)2.6 ( E)2 (n)10.5 (g)-11.2 (l)2.6 ( J)8.8 ( M)15.8 (ed )]TJ 0.002 Tw 0 -1.141 Td [(2003;)-6.6 (349:)-6.6 (1517)]TJ 0 Tc 0 Tw 6.652 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1525.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.989 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (14561794)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 291.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 289.08 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 267.48 Tm [(454.)-6.7 ( S)12.9 (k)-12.9 (i)2.6 (nner)4.9 ( M)15.8 (A)1.9 (,)-6.6 ( M)15.8 (ol)2.7 (e)-11.3 (y)8.9 ( )-10.5 (J)-2 (A)2 (,)-6.6 ( D)2.6 (i)2.6 (l)2.6 (l)2.6 (ey)8.9 ( )22.1 (W)-36.3 (G)4.3 (,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( P)12.8 (r)-5.9 (o)10.5 (phy)8.9 (l)2.6 (ac)-2 (t)-6.7 (i)2.7 (c)-2 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (dec)-2 (t)-6.6 (om)-5.9 (y)8.8 ( )]TJ 0 -1.141 Td [(i)2.6 (n m)-6 (ul)2.6 (t)-6.6 (i)2.6 (pl)2.6 (e endoc)8.9 (r)-6 (i)2.6 (ne neo)10.5 (pl)2.6 (as)-2 (i)2.6 (a t)-6.6 (y)8.9 (pe 2A)2 (.)-6.6 ( N)13.5 ( E)1.9 (ng)-11.2 (l)13.4 ( J)-2 ( )11.3 (M)15.8 (ed 2005;)-6.6 (353:)-6.7 (1105)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 0 -1.152 Td [(1113.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.3 (/)4.3 (w)2.6 (w)2.6 (w)13.4 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.7 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)-6.6 (g)-11.3 (ov)8.9 (/)-6.6 (pu)10.5 (bm)-6 (ed/)-6.6 (16162881)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 345.84 242.16 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 117.24 240.12 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 218.52 Tm [(455.)-6.7 ( B)2 (r)-6 (i)2.7 (e)10.5 (r)-6 (l)2.6 (ey)8.9 ( J)-2 (,)-6.5 ( S)1.9 (her)4.9 (m)-5.9 (an)10.6 ( E)2 (.)-6.6 ( )11.3 (T)-10.6 (he)10.5 ( r)-6 (ol)2.6 (e)10.5 ( o)10.5 (f)-6.6 ( ex)8.8 (t)-6.6 (er)-6 (nal)2.6 ( b)10.6 (eam)-6 ( )11.3 (r)-6 (adi)2.6 (at)-6.6 (i)2.6 (on and)10.5 ( )]TJ 0 -1.141 Td [(t)-6.6 (ar)5 (g)-11.3 (e)10.6 (t)-6.6 (ed )11.2 (t)-6.6 (her)-5.9 (apy)8.9 ( i)2.6 (n )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (.)-6.6 ( S)2 (e)10.5 (m)-6 (i)2.6 (n R)2.6 (adi)2.6 (at)4.2 ( )11.3 (O)-6.6 (nc)-2 (ol)2.6 ( 2012)10.5 (;)-6.6 (22:)-6.6 (254)]TJ 0 Tc 0 Tw 30.076 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(262.)4.2 ( )]TJ 0.007 Tw -30.413 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (22687950)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 193.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 191.28 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 169.68 Tm [(456.)-6.7 ( B)2 (r)-6 (i)2.7 (e)10.5 (r)-6 (l)2.6 (ey)8.9 ( J)-2 (,)-6.5 ( )11.2 (T)-10.5 (s)-2.1 (an)10.5 (g R)2.6 (,)4.3 ( S)2 (i)2.6 (m)-5.9 (ps)-2 (on )33 (W)-36.2 (J)8.8 (,)4.3 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( M)15.8 (edul)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)-6 (:)4.3 ( )]TJ 0 -1.152 Td [(anal)2.6 (y)8.8 (s)-2 (es)-2 ( of)-6.6 ( s)-2 (ur)-6 (v)8.9 (i)2.6 (v)8.9 (al)2.7 ( and pr)-6 (o)10.5 (g)-11.2 (nos)-2 (t)-6.6 (i)2.6 (c)8.9 ( )11.3 (f)-17.5 (ac)8.9 (t)-6.6 (or)-5.9 (s)8.9 ( and)10.5 ( t)-6.6 (h)10.5 (e )0.5 (r)-6 (ol)2.6 (e o)10.5 (f)-6.6 ( )11.3 (r)-6 (adi)2.6 (at)-6.6 (i)2.6 (on )]TJ 0 -1.141 Td [(t)-6.6 (her)-6 (apy)8.9 ( i)2.6 (n l)2.6 (oc)-2 (al)2.6 ( c)-2 (on)10.6 (t)-6.6 (r)-6 (ol)2.6 (.)4.2 ( )11.3 (T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d 1996;)-6.6 (6)10.6 (:)-6.7 (305)]TJ 0 Tc 0 Tw 19.109 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(310.)4.2 ( A)2 (v)8.8 (ai)]TJ 4.141 0 Td [(l)2.6 (ab)-11.2 (l)2.6 (e at)-6.7 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -23.587 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (8875751)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 131.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 129.6 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 108 Tm [(457.)-6.7 ( v)8.9 (an H)2.6 (eer)-5.9 (den)10.5 ( J)-2 (A)2 (,)4.2 ( G)4.3 (r)4.9 (ant)-6.6 ( C)2.6 (S)2 (,)4.2 ( G)4.3 (har)-6 (i)2.6 (b H)13.5 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( )11.3 (Long)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 24.152 0 Td [(t)-6.6 (e)10.5 (r)-5.9 (m)4.9 ( c)-2 (our)4.9 (s)-2 (e o)10.6 (f)-6.7 ( )]TJ -24.152 -1.141 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h per)5 (s)-2 (i)2.6 (s)-2 (t)-6.6 (en)10.5 (t)-6.6 ( h)10.6 (y)8.8 (per)-5.9 (c)-2 (al)2.6 (c)-2 (i)2.7 (t)-6.7 (oni)2.6 (nem)-6 (i)2.6 (a a)10.5 (f)-17.5 (t)-6.6 (e)10.5 (r)-5.9 ( )11.2 (appar)-5.9 (ent)4.3 ( c)-2 (ur)-5.9 (a)10.5 (t)-6.6 (i)2.6 (v)8.9 (e )]TJ 0 -1.152 Td [(pr)-6 (i)2.6 (m)-6 (ar)-5.9 (y)8.8 ( s)-2 (u)10.5 (r)5 (g)-11.3 (er)-6 (y)8.9 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )11.2 (m)-5.9 (ed)10.5 (ul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a.)4.2 ( )11.3 (A)2 (nn S)1.9 (ur)4.9 (g)-11.2 ( 1990)10.6 (;)-6.7 (212:)-6.6 (3)10.5 (95)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 0 -1.141 Td [(400;)-6.7 ( di)2.6 (s)-2 (c)-2 (us)-2 (s)-2 (i)2.6 (on)10.5 ( )0.5 (400)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 9.152 0 Td [(391)10.5 (.)4.3 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (ab)-11.2 (l)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -9.152 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (2222011)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 57.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 55.44 222.601 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(458.)-6.7 ( S)2 (c)-2 (ops)-2 (i)2.6 ( L)10.5 (,)4.3 ( S)2 (am)-5.9 (pi)2.6 (et)4.2 (r)4.9 (o G)4.3 (,)-6.7 ( )0.5 (B)1.9 (o)10.5 (r)-5.9 (ac)-2 (c)-2 (hi)2.6 ( P)12.8 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( M)5 (ul)2.6 (t)-6.6 (i)2.6 (v)8.9 (ar)-5.9 (i)2.6 (at)-6.6 (e anal)2.7 (y)8.8 (s)-2 (i)2.6 (s)-2 ( of)-6.6 ( )]TJ 0 -1.152 Td [(pr)-6 (o)10.5 (g)-11.2 (nos)-2 (t)-6.6 (i)2.6 (c)8.9 ( )11.2 (f)-17.4 (ac)8.9 (t)-6.6 (or)-5.9 (s)8.8 ( )0.5 (i)2.6 (n s)-2 (po)10.5 (r)-6 (adi)2.6 (c)-2 ( )0.5 (m)-6 (ed)10.6 (ul)2.6 (l)2.6 (ar)-6 (y)8.9 ( c)-2 (ar)-6 (c)-2 (i)2.6 (nom)4.9 (a o)10.5 (f)-6.6 ( t)-6.6 (he)10.5 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d.)4.3 ( A)2 ( )]TJ 0 -1.141 Td [(r)-6 (et)-6.6 (r)4.9 (os)-2 (pec)-2 (t)-6.6 (i)2.6 (v)8.8 (e s)-2 (t)-6.6 (udy)8.9 ( o)]TJ 9.196 0 Td [(f)-6.6 ( 10)10.6 (9 c)-2 (ons)-2 (ec)-2 (u)10.5 (t)-6.6 (i)2.6 (v)8.9 (e pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 (.)4.3 ( )11.3 (C)2.6 (anc)-2 (er)-5.9 ( 1996)10.6 (;)-6.7 (78:)-6.7 (2173)]TJ 0 Tc 0 Tw 21.663 0 Td (-)Tj -0.002 Tc 0.007 Tw -30.859 -1.152 Td [(2183.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.3 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.7 (nc)-2 (bi)2.6 (.)-6.7 (nl)2.6 (m)-5.9 (.)-6.7 (ni)2.6 (h.)-6.6 (g)-11.3 (ov)8.9 (/)-6.7 (pu)10.5 (bm)-6 (ed/)-6.6 (8918412)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 721.2 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 498.72 473.88 222.48 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 452.28 Tm [(459.)-6.7 ( )11.3 (T)-10.5 (i)2.6 (s)-2 (el)2.6 (l)2.6 ( LE)1.9 (,)4.3 ( H)2.6 (ans)-2 (s)-2 (on )11.3 (G)-6.6 (,)4.3 ( J)-2 (ans)-2.1 (s)-2 (on)10.5 ( S)2 (,)4.2 ( S)2 (al)2.7 (ander)-6 ( )11.3 (H)2.6 (.)-6.6 ( R)2.6 (eoper)-5.9 (a)10.5 (t)-6.6 (i)2.6 (on i)2.6 (n )11.3 (t)-6.6 (he )]TJ -0.013 Tc 0.018 Tw 0 -1.141 Td [(t)-17.6 (r)-17 (e)-11.3 (at)-17.6 (m)-17 (e)-11.3 (nt)-17.6 ( of)-17.6 ( as)-13 (y)]TJ -0.002 Tc 0.007 Tw 7.141 0 Td [(m)-6 (pt)-6.6 (o)10.5 (m)-5.9 (at)4.3 (i)2.6 (c)-2 ( m)-6 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (as)-2 (i)2.6 (z)8.9 (i)2.6 (ng)-11.2 ( )11.2 (m)-5.9 (edul)2.6 (l)2.7 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (no)10.5 (m)-6 (a.)4.2 ( )]TJ -7.141 -1.152 Td [(S)2 (ur)-5.9 (g)-11.3 (e)10.6 (r)-6 (y)8.9 ( 1986;)-6.6 (99)10.6 (:)-6.7 (60)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 9.098 0 Td [(66)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)-8.2 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -9.098 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (3942001)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 412.32 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 390.72 Tm [(460.)-6.7 ( M)15.8 (ol)2.6 (ey)8.9 ( J)-2 (F,)-6.6 ( D)2.6 (ebenedet)-6.6 (t)-6.6 (i)2.6 ( M)15.8 (K)1.9 (,)-6.6 ( D)2.6 (i)2.6 (l)2.7 (l)2.6 (ey)8.9 ( )22.1 (W)-36.2 (G)4.2 (,)-6.6 ( e)10.5 (t)-6.6 ( )11.3 (al)2.6 (.)-6.6 ( )11.3 (S)2 (ur)-5.9 (g)-11.3 (i)2.6 (c)-2 (al)2.6 ( )11.3 (m)-6 (ana)10.6 (g)]TJ -0.013 Tc 0.018 Tw 28.87 0 Td [(em)-16.9 (e)-11.4 (n)-11.3 (t)-6.8 ( of)-17.6 ( )]TJ -0.002 Tc 0.007 Tw -28.87 -1.152 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h per)5 (s)-2 (i)2.6 (s)-2 (t)-6.6 (en)10.5 (t)-6.6 ( o)10.6 (r)-6 ( r)-6 (e)10.6 (c)-2 (ur)4.9 (r)-5.9 (ent)4.2 ( m)-5.9 (edul)2.6 (l)2.7 (ar)-5.9 (y)8.8 ( t)-6.6 (hy)19.7 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-6 (.)4.3 ( J)-2 ( )11.3 (I)-6.6 (nt)-6.6 (e)10.5 (r)-5.9 (n M)15.8 (ed )]TJ 0.002 Tw 0 -1.141 Td [(1998;)-6.6 (243:)-6.6 (521)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(526.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9681853)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 350.76 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 329.16 Tm [(461.)-6.7 ( Fl)2.6 (em)-5.9 (i)2.6 (n)10.5 (g J)-2 (B)2 (,)4.3 ( Lee J)-2 (E)12.8 (,)-6.6 ( B)2 (ouv)8.9 (et)-6.6 ( M)15.8 (,)-6.6 ( )]TJ [(et)4.3 ( al)2.5 (.)4.3 ( S)2 (ur)4.9 (g)-11.2 (i)2.6 (c)8.9 (al)2.6 ( s)-2 (t)-6.6 (r)-6 (a)10.5 (t)-6.6 (e)10.5 (g)-11.2 (y)8.9 ( )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )11.2 (t)-6.6 (he )]TJ 0 -1.152 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a.)4.3 ( A)2 (nn S)1.9 (u)10.5 (r)-5.9 (g 1999)10.5 (;)-6.6 (230:)-6.6 (697)]TJ 0 Tc 0 Tw 29.141 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(707.)4.2 ( )]TJ 0.007 Tw -29.478 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (10561095)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 303.84 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 301.8 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 280.2 Tm [(462.)-6.7 ( H)2.7 (addad)10.5 ( R)2.6 (I)-6.6 (.)4.2 ( H)2.7 (ow)13.5 ( t)-6.6 (o )11.3 (i)2.6 (nc)-2 (or)-5.9 (por)-6 (at)-6.6 (e)10.5 ( new)13.5 ( t)-6.7 (y)8.9 (r)-5.9 (os)-2 (i)2.6 (ne )11.3 (k)-12.9 (i)2.6 (nas)-1.9 (e i)2.6 (nhi)2.6 (bi)2.6 (t)-6.6 (or)-5.9 (s)8.9 ( i)2.6 (n t)-6.6 (he)10.6 ( )]TJ 0 -1.152 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (i)2.7 (t)-6.7 (h m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)8.8 (er)-6 (.)4.3 ( J)-2 ( C)2.6 (l)2.6 (i)2.6 (n )11.2 (O)-6.6 (nc)-2 (ol)2.7 ( )]TJ 0.002 Tw 0 -1.141 Td [(2013;)-6.6 (31:)-6.6 (3618)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(3620.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -6.435 -1.152 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)6.6 (l)9.6 (m)1.1 (.n)6.6 (i)9.7 (h)6.6 (.)]TJ -0.002 Tc 0.002 Tw 10.522 0 Td [(gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24002516)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 242.16 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 240.12 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 218.52 Tm [(463.)-6.7 ( A)2 (l)2.6 (em)-6 (an)10.5 ( J)8.8 (O)-6.5 (,)4.2 ( Far)-6 (oo)10.5 (k)-12.9 (i)13.5 ( A)2 (,)-6.7 ( )11.3 (G)-6.6 (i)2.6 (r)-6 (o)10.6 (t)-6.6 (r)-6 (a)10.6 ( M)15.8 (.)-6.6 ( E)12.8 (f)-6.6 (f)-17.5 (e)10.6 (c)-2 (t)-6.6 (s)8.8 ( o)10.6 (f)-6.7 ( )0.5 (t)4.2 (y)8.9 (r)-6 (os)-2 (i)2.6 (ne k)-12.9 (i)2.6 (nas)-2 (e)10.6 ( i)2.6 (nhi)2.6 (bi)2.6 (t)-6.6 (i)2.6 (on )]TJ 0 -1.141 Td [(on bone )11.3 (m)-6 (et)-6.6 (abol)2.6 (i)2.6 (s)-1.9 (m)4.9 (:)4.2 ( unt)4.3 (ar)4.9 (g)-11.3 (et)-6.6 (ed)10.6 ( c)-2 (ons)-2 (e)10.5 (q)-11.2 (uenc)-2 (es)8.9 ( o)10.5 (f)-6.6 ( )11.2 (t)-6.6 (ar)4.9 (g)-11.2 (e)10.5 (t)-6.6 (ed )11.3 (t)-6.6 (her)-6 (api)2.6 (es)8.9 (.)-6.7 ( )]TJ 0 -1.141 Td [(E)2 (ndoc)-2 (r)-5.9 ( R)2.6 (el)2.6 (at)4.2 ( C)2.7 (anc)-2 (er)4.9 ( 20)10.5 (14;)-6.6 (21:)-6.6 (R)2.6 (247)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 16.13 0 Td [(259)10.5 (.)4.3 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (ab)-11.2 (l)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -16.13 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24478055)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 180.6 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 178.56 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 156.96 Tm [(464.)-6.7 ( S)2 (her)4.9 (m)-5.9 (an)10.6 ( S)2 (I)4.3 (.)-6.6 ( Les)-2 (s)-2 (o)10.5 (ns)-2 ( l)2.6 (ear)-6 (ned )0.5 (and)10.5 ( )11.2 (q)-11.2 (ues)8.9 (t)-6.6 (i)2.6 (ons)-2 ( unans)-2 (w)13.5 (er)-6 (ed )11.3 (f)-6.6 (r)-6 (om)4.9 ( us)-2 (e)10.6 ( )11.2 (o)10.5 (f)-17.4 ( )]TJ 0 -1.141 Td [(m)-6 (ul)2.6 (t)-6.6 (i)2.6 (t)-6.6 (ar)4.9 (g)-11.2 (e)10.5 (t)-6.6 (ed)10.5 ( )11.3 (k)-12.9 (i)2.7 (nas)-1.9 (e i)2.6 (nhi)2.6 (bi)2.6 (t)-6.6 (or)-5.9 (s)-2 ( i)2.6 (n)10.5 ( m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 (.)-6.7 ( )11.3 (O)4.3 (r)-6 (al)2.6 ( O)4.2 (nc)-2 (ol)2.6 ( )]TJ 0.002 Tw 0 -1.152 Td [(2013;)-6.6 (49:)-6.6 (707)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(710.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (23582411)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 119.04 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 117 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 95.4 Tm [(465.)-6.7 ( K)2 (ur)-6 (z)8.9 (r)-6 (oc)8.8 (k)-2 ( R)2.7 (,)4.2 ( S)2 (her)4.9 (m)4.9 (an S)2 (I)-6.7 (,)4.3 ( B)2 (al)2.6 (l)2.6 ( D)24.4 (W)-36.3 (,)4.3 ( )11.3 (e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( A)1.9 (c)-2 (t)4.3 (i)2.6 (v)-2 (i)2.6 (t)-6.6 (y)8.9 ( of)-6.6 ( )11.3 (X)-8.9 (L184 )]TJ 0 -1.152 Td [(\()-6 (C)2.7 (aboz)8.9 (ant)-6.6 (i)2.6 (ni)2.7 (b\))-5.9 (,)-6.6 ( an o)10.6 (r)-6 (al)2.6 ( )11.3 (t)4.2 (y)8.9 (r)-6 (os)-2 (i)2.6 (ne k)-12.9 (i)2.6 (nas)-2 (e)10.6 ( i)2.6 (nhi)2.6 (bi)2.6 (t)-6.6 (or)-6 (,)4.3 ( i)2.6 (n pat)-6.7 (i)2.7 (ent)-6.7 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h m)-6 (edul)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 (.)-6.7 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n O)-6.6 (n)10.5 (c)-2 (ol)]TJ 0 Tc 0 Tw 12.185 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.283 0 Td [(2011;)-6.6 (29:)4.3 (2660)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 6.435 0 Td [(2666)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)-8.3 (l)2.7 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -18.902 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21606412)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 57.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 55.44 228.72 0.84 re f EMC endstream endobj 1108 0 obj 27539 endobj %% Contents for page 131 %% Original object ID: 263 0 1109 0 obj << /Length 1110 0 R >> stream Q q BT /Xi129 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1110 0 obj 246 endobj %% Original object ID: 11967 0 1111 0 obj [ 3110 0 R 3111 0 R 3112 0 R 3113 0 R 3114 0 R 3115 0 R 3116 0 R 3117 0 R 3118 0 R 3119 0 R 3120 0 R 3121 0 R 3122 0 R 3123 0 R 3124 0 R ] endobj %% Contents for page 132 %% Original object ID: 264 0 1112 0 obj << /Length 1113 0 R >> stream q endstream endobj 1113 0 obj 2 endobj %% Contents for page 132 %% Original object ID: 11968 0 1114 0 obj << /Length 1115 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (69)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(466.)-6.7 ( R)2.7 (obi)2.6 (ns)-2 (on B)12.8 (G)-6.5 (,)4.2 ( P)2 (az)]TJ 0 Tc 0 Tw 10.413 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(A)2 (r)-6 (es)-2.1 ( )0.5 (L)10.5 (,)-6.6 ( K)1.9 (r)-5.9 (eb)10.5 (s)-2 ( A)12.9 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( V)12.8 (andet)-6.6 (ani)2.6 (b \()-6 (100)10.6 ( m)4.9 (g\))4.9 ( i)2.6 (n )]TJ -10.75 -1.152 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h l)2.6 (oc)-2 (al)2.6 (l)2.6 (y)8.8 ( adv)8.8 (a)-11.2 (nc)-2 (ed or)4.9 ( m)-5.9 (e)10.5 (t)-6.6 (as)8.9 (t)-6.6 (at)-6.6 (i)2.7 (c)8.8 ( her)]TJ 20.891 0 Td [(ed)10.5 (i)2.6 (t)-6.6 (ar)-5.9 (y)8.8 ( m)-5.9 (edul)2.7 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ -20.891 -1.141 Td [(c)-2 (anc)-2 (er)-6 (.)4.3 ( J)8.8 ( C)2.6 (l)2.7 (i)2.6 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2010;)-6.6 (95:)-6.6 (2664)]TJ 0 Tc 0 Tw 20.446 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(26)10.5 (71.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -20.783 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (20371662)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 473.88 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 452.28 Tm [(467.)-6.7 ( )11.3 (G)-6.6 (r)-5.9 (ande)10.5 ( E)2 (,)4.2 ( K)2 (r)-6 (ei)2.6 (s)-2 (s)-2 (l)2.6 ( )11.3 (M)4.9 (C)2.6 (,)-6.6 ( Fi)2.6 (l)2.6 (et)-6.6 (t)-6.6 (i)2.6 ( S)1.9 (,)4.3 ( et)4.3 ( al)2.6 (.)4.2 ( V)2 (and)10.5 (et)-6.6 (ani)2.6 (b i)2.6 (n a)]TJ 0.002 Tw [(dv)8.9 (anc)-2 (ed )]TJ 0.007 Tw 0 -1.141 Td [(m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (:)-6.6 ( )11.3 (r)-6 (ev)8.9 (i)2.6 (e)-11.2 (w)13.4 ( of)-6.6 ( adv)8.9 (er)-5.9 (s)-2 (e ev)8.9 (ent)4.3 ( m)-6 (ana)10.6 (g)-11.3 (e)10.6 (m)-6 (ent)4.3 ( s)8.8 (t)-6.6 (r)-5.9 (a)10.5 (t)-6.6 (e)10.5 (g)-11.2 (i)2.6 (es)-2 (.)4.2 ( )]TJ 0 -1.152 Td [(A)2 (dv)8.9 ( T)-10.6 (her)4.9 ( 2013;)-6.6 (30)10.5 (:)-6.6 (945)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 10.207 0 Td [(9)10.5 (66.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -10.207 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24249433)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 412.32 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 390.72 Tm [(468.)-6.7 ( S)2 (c)-2 (hl)2.6 (um)-5.9 (be)10.6 (r)4.9 (g)-11.3 (er)4.9 ( M)15.8 (,)-6.6 ( E)1.9 (l)2.6 (i)2.7 (s)-2 (ei)2.6 ( R)2.6 (,)]TJ 0 Tc 0 Tw 13.739 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(M)15.8 (ul)2.6 (l)2.7 (er)-5.9 ( S)1.9 (,)-6.6 ( et)4.3 ( al)2.6 (.)-6.6 ( )11.2 (O)-6.6 (v)8.9 (er)-6 (al)2.6 (l)2.6 ( s)-2 (ur)-5.9 (v)8.8 (i)2.6 (v)8.9 (al)2.6 ( anal)-8.2 (y)8.9 (s)-2.1 (i)2.6 (s)-2 ( )0.5 (of)-17.5 ( )]TJ -14.022 -1.152 Td [(E)2 (X)-9 (A)2 (M)15.8 (,)-6.6 ( a phas)-2 (e)10.5 ( I)4.3 (I)-6.6 (I)4.2 ( t)4.3 (r)-6 (i)2.6 (al)2.6 ( o)10.5 (f)-6.6 ( c)-2 (aboz)8.8 (ant)-6.6 (i)2.6 (ni)2.6 (b i)2.6 (n pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( )11.3 (w)2.6 (i)2.6 (t)-6.6 (h r)-5.9 (adi)2.6 (o)10.5 (g)-11.2 (r)-6 (aphi)2.6 (c)-2 (al)2.7 (l)2.6 (y)8.8 ( )]TJ 0 -1.141 Td [(pr)-6 (o)10.5 (g)-11.2 (r)-5.9 (es)-2 (s)-2 (i)2.6 (v)8.9 (e m)-5.9 (edul)2.7 (l)2.6 (ar)-5.9 (y)8.8 ( t)-6.6 (h)10.5 (y)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a.)4.2 ( A)2 (nn )11.3 (O)-6.6 (n)10.5 (c)-2 (ol)2.6 ( )0.5 (2017;)-6.7 (28:)4.2 (2813)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 29.815 0 Td [(2819)10.5 (.)-6.6 ( )]TJ 0.007 Tw -29.815 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)13.5 (w)2.6 (w)-8.3 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)4.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-6 (e)10.5 (d/)-6.6 (29045520)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 320.88 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 350.76 234.239 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 329.16 Tm [(469.)-6.7 ( S)2 (her)4.9 (m)-5.9 (an)10.6 ( S)2 (I)4.3 (,)-6.6 ( C)2.7 (l)2.6 (ar)-5.9 (y)8.8 ( )11.3 (D)2.6 (O)-6.6 (,)4.3 ( E)1.9 (l)2.6 (i)2.6 (s)-2 (ei)2.6 ( R)2.6 (,)-6.6 ( et)4.2 ( al)2.6 (.)4.2 ( C)2.6 (or)-5.9 (r)-6 (e)10.5 (l)2.6 (at)-6.6 (i)2.6 (v)8.8 (e anal)-8.2 (y)8.9 (s)-2 (es)-2 ( o)10.5 (f)-17.4 ( R)2.6 (E)12.8 (T)-10.6 ( )]TJ 0 -1.152 Td [(and R)2.6 (A)1.9 (S)2 ( m)-6 (u)10.6 (t)-6.7 (at)-6.6 (i)2.6 (ons)8.9 ( i)2.6 (n a )11.2 (phas)-2 (e 3 )11.3 (t)-6.6 (r)-6 (i)2.6 (al)2.6 ( o)10.5 (f)-6.6 ( c)-2 (aboz)8.9 (ant)-6.6 (i)13.5 (ni)2.7 (b i)2.6 (n pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.4 (i)2.6 (t)-6.6 (h )]TJ 0 -1.141 Td [(pr)-6 (o)10.5 (g)-11.2 (r)-5.9 (es)-2 (s)-2 (i)2.6 (v)8.9 (e,)-6.6 ( )11.3 (m)-6 (et)-6.6 (a)10.5 (s)-2 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (.)-6.6 ( C)2.6 (anc)-2 (e)10.6 (r)-6 ( 2)]TJ 0.002 Tw [(016)10.5 (;)-6.6 (122:)-6.6 (3856)]TJ 0 Tc 0 Tw 32.076 0 Td (-)Tj -0.002 Tc 0.007 Tw -32.076 -1.152 Td [(3864.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (ps)8.8 (:)4.3 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.4 (.)-6.5 (nc)-2 (bi)2.6 (.)-6.7 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)-6.6 (g)-11.3 (ov)8.9 (/)-6.6 (p)10.5 (ubm)-6 (ed/)-6.6 (27525386)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 351.36 291.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 117.24 289.08 234.12 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 267.48 Tm [(470.)-6.7 ( E)2 (i)2.6 (s)-2 (enhauer)5 ( E)1.9 (A)2 (,)4.2 ( )11.3 (T)-10.6 (h)10.5 (er)-6 (as)-2 (s)-2 (e P)12.9 (,)-6.6 ( B)1.9 (o)10.6 (g)-11.3 (ae)10.5 (r)-5.9 (t)-6.7 (s)8.9 ( J)8.9 (,)-6.6 ( e)10.5 (t)-6.6 ( )11.3 (al)2.6 (.)-6.6 ( N)2.6 (ew)13.4 ( r)-5.9 (es)-2 (pons)-2 (e )]TJ 0 -1.141 Td [(ev)8.8 (al)2.6 (uat)-6.6 (i)2.6 (on c)-2 (r)-6 (i)2.7 (t)-6.6 (er)-6 (i)2.7 (a i)2.6 (n s)-2 (ol)2.6 (i)13.5 (d t)-6.7 (u)10.6 (m)-6 (our)-5.9 (s)8.8 (:)-6.6 ( )11.3 (r)-6 (ev)8.9 (i)2.6 (s)-2 (ed R)2.6 (E)2 (C)2.6 (I)-6.7 (S)2 (T)]TJ 0 Tc 0 Tw 22.772 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.272 0 Td [(g)-11.2 (ui)2.6 (del)2.6 (i)2.6 (ne \()-6 (v)8.9 (er)-5.9 (s)-2 (i)2.6 (on )]TJ -23.043 -1.152 Td [(1.)-6.7 (1\))4.9 (.)-6.6 ( E)2 (ur)4.9 ( J)8.9 ( C)2.6 (anc)-2 (er)4.9 ( 2009;)4.2 (45:)-6.7 (228)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.25 0 Td [(247)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.25 -1.141 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (19097774)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.76 229.56 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 227.52 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 205.92 Tm [(471.)-6.7 ( )33.1 (W)-36.3 (el)2.7 (l)2.6 (s)8.8 ( S)2 (A)1.9 (,)-6.6 ( J)8.9 (r)-5.9 (.)4.2 (,)4.3 ( G)-6.6 (os)-2 (n)10.5 (el)2.6 (l)2.6 ( J)-2 (E)2 (,)-6.6 ( )11.2 (G)-6.6 (a)10.6 (g)-11.3 (el)2.6 ( R)2.6 (F,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( V)12.9 (andet)-6.6 (ani)2.6 (b )11.3 (f)-17.5 (o)10.5 (r)-5.9 ( )11.3 (t)-6.7 (he )]TJ 0.005 Tc 0 Tw 0 -1.141 Td [(tr)1 (e)6.7 (a)17.5 (tm)1.1 (e)6.6 (n)17.6 (t o)]TJ -0.002 Tc 0.007 Tw 5.043 0 Td [(f)-6.6 ( pa)10.6 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h l)2.6 (oc)-2 (al)2.6 (l)2.6 (y)8.9 ( adv)8.8 (anc)-2 (ed or)-5.9 ( m)-6 (e)10.5 (t)-6.6 (as)-2 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( he)10.6 (r)-6 (edi)2.6 (t)-6.6 (ar)-6 (y)8.9 ( )]TJ -5.043 -1.152 Td [(m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (.)-6.6 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n O)-6.6 (nc)-2 (ol)2.6 ( 2010)10.6 (;)-6.7 (28)10.5 (:)-6.6 (7)10.6 (67)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 22.935 0 Td [(772.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.935 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (20065189)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 168 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 165.96 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 144.36 Tm [(472.)-6.7 ( S)2 (her)4.9 (m)-5.9 (an)10.6 ( S)2 (I)4.3 (.)-6.6 ( A)2 (dv)8.8 (anc)]TJ 11.359 0 Td [(es)-2 ( i)2.6 (n c)-2 (he)10.5 (m)-6 (ot)-6.6 (he)10.6 (r)-6 (apy)8.9 ( o)10.5 (f)-6.6 ( )11.3 (di)2.6 (f)-6.6 (f)-6.6 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.3 (epi)2.6 (t)-6.6 (hel)2.6 (i)2.6 (al)2.6 ( )]TJ -11.359 -1.152 Td [(and m)-6 (edul)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.5 (nc)-2 (er)-6 (s)-2 (.)4.2 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( )11.3 (M)15.7 (et)-6.6 (ab 2009;)-6.6 (94:)-6.6 (1493)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 0 -1.141 Td [(1499.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.3 (/)4.3 (w)2.6 (w)2.6 (w)13.4 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.7 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)-6.6 (g)-11.3 (ov)8.9 (/)-6.6 (pu)10.5 (bm)-6 (ed/)-6.6 (19258410)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 345.84 119.04 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 117.24 117 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 95.4 Tm [(473.)-6.7 ( La)10.5 (m)-5.9 ( E)12.8 (T,)-6.6 ( R)2.6 (i)]TJ 7.207 0 Td [(n)10.5 (g)-11.2 (el)2.6 ( M)15.7 (D)-8.2 (,)-6.6 ( K)1.9 (l)2.6 (oos)-1.9 ( R)13.4 (T,)-6.6 ( e)10.6 (t)-6.7 ( al)2.6 (.)4.3 ( P)2 (has)-2 (e)10.5 ( I)4.3 (I)-6.6 ( c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( t)-6.6 (r)-5.9 (i)2.6 (al)2.6 ( o)10.6 (f)-6.7 ( )11.3 (s)-2 (or)-6 (a)10.5 (f)-6.6 (eni)2.6 (b )]TJ -7.207 -1.152 Td [(i)2.6 (n m)-6 (et)-6.7 (a)10.6 (s)-2 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( )11.2 (m)-5.9 (edul)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( t)4.3 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)-6 (.)4.3 ( J)-2 ( C)2.6 (l)2.6 (i)2.6 (n )11.3 (O)-6.6 (n)10.5 (c)-2 (ol)2.6 ( 2010;)-6.6 (28:)4.2 (2323)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 29.359 0 Td [(2330)10.5 (.)-6.6 ( )]TJ 0.007 Tw -29.359 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (20368568)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 70.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 68.04 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 405 513.96 Tm (47)Tj 0.007 Tw [(4.)-6.7 ( K)2 (el)2.6 (l)2.6 (eher)-5.9 ( FC)13.5 (,)-6.6 ( M)15.8 (c)-2 (D)2.6 (er)-6 (m)-5.9 (ot)4.3 (t)-6.6 ( R)13.5 (.)-6.6 ( R)2.6 (es)-2 (pons)-2 (e)10.5 ( t)-6.6 (o)10.5 ( s)-2 (un)10.5 (i)2.6 (t)-6.6 (i)2.6 (ni)2.6 (b i)2.6 (n m)-6 (edul)2.6 (l)2.6 (ar)-5.9 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (anc)-2 (er)-6 (.)4.3 ( A)1.9 (nn )11.3 (I)-6.6 (nt)-6.6 (e)10.6 (r)-6 (n M)15.8 (ed )11.2 (2008;)-6.6 (148:)-6.6 (567)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 0 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (18378960)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 488.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 486.6 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 465 Tm [(475.)-6.7 ( B)2 (i)2.6 (bl)2.6 (e K)2 (C)2.6 (,)-6.6 ( S)1.9 (u)10.6 (m)-6 (an)10.5 ( V)1.9 (J)-2 (,)-6.6 ( M)15.8 (ol)]TJ 13.402 0 Td [(i)2.6 (na J)-2 (R)2.6 (,)-6.6 ( et)4.2 ( al)2.6 (.)4.2 ( A)2 ( )11.3 (m)-6 (ul)2.6 (t)-6.6 (i)2.6 (c)-2 (ent)-6.6 (er)4.9 ( phas)-2 (e)10.5 ( 2 )11.2 (t)-6.6 (r)-5.9 (i)2.6 (al)2.7 ( o)10.6 (f)-6.6 ( )]TJ -13.402 -1.152 Td [(paz)8.9 (opani)2.6 (b i)2.7 (n m)-5.9 (et)-6.6 (as)8.8 (t)-6.6 (at)-6.6 (i)2.6 (c)-2 ( )11.2 (and pr)-6 (o)10.5 (gr)-6 (es)-2 (s)-2 (i)2.6 (v)8.9 (e m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (a:)4.3 ( )]TJ 0 -1.141 Td [(M)4.9 (C)2.6 (057H)2.6 (.)-6.6 ( J)-2 ( C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)13.5 (nol)2.6 ( M)15.8 (et)-6.5 (ab 2014;)-6.6 (99:)-6.7 (1687)]TJ 0 Tc 0 Tw 21.38 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(1693.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -21.707 -1.152 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.)]TJ -0.002 Tc 0.002 Tw [(nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.8 (/)-6.6 (pubm)-6 (ed/)-6.6 (24606083)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 426.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 424.92 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 403.32 Tm [(476.)-6.7 ( S)2 (c)-2 (hl)2.6 (um)-5.9 (be)10.6 (r)4.9 (g)-11.3 (er)4.9 ( M)15.8 (,)-6.6 ( J)8.8 (ar)-6 (z)8.9 (ab B)2 (,)-6.6 ( C)2.6 (abani)2.6 (l)2.6 (l)2.6 (as)-2 ( M)15.8 (E)1.9 (,)-6.6 ( et)-6.7 ( al)2.6 (.)4.3 ( A)1.9 ( P)2 (has)-2 (e)10.5 ( I)4.3 (I)-6.6 ( )11.2 (Tr)-5.9 (i)2.6 (al)2.6 ( o)10.6 (f)-6.7 ( )]TJ 0 -1.141 Td [(t)-6.6 (he M)15.8 (ul)2.6 (t)-6.6 (i)2.6 (t)-6.6 (ar)4.9 (g)-11.2 (et)-6.6 (ed)10.5 ( )11.3 (T)-10.6 (y)8.9 (r)-6 (os)-2 (i)2.6 (ne K)2 (i)2.6 (nas)-2 (e I)-6.6 (nhi)2.6 (bi)2.6 (t)-6.6 (o)10.5 (r)-5.9 ( Lenv)8.9 (at)4.3 (i)2.6 (ni)2.6 (b \()-5.9 (E)1.9 (7080\))-5.9 ( i)2.6 (n )]TJ 0 -1.152 Td [(A)2 (dv)8.9 (anc)-2 (ed )-10.5 (M)15.8 (edul)2.6 (l)2.6 (ar)-16.8 (y)8.9 ( T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d C)2.6 (anc)-2 (er)4.9 (.)-6.6 ( C)2.6 (l)2.6 (i)2.6 (n C)2.5 (anc)-2 (er)4.9 ( R)2.6 (es)-2 ( 2016)10.5 (;)-6.6 (22:)-6.6 (44)]TJ 0 Tc 0 Tw 29.196 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(53.)4.3 ( )]TJ 0.007 Tw -29.533 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)13.5 (w)2.6 (w)-8.3 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)4.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-6 (e)10.5 (d/)-6.6 (26311725)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 702.36 365.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 363.36 234.24 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 341.76 Tm [(477.)-6.7 ( )11.3 (O)-6.6 (r)-5.9 (l)2.6 (andi)2.6 ( F)11.2 (,)-6.6 ( C)2.6 (ar)-6 (a)10.5 (c)-2 (i)2.6 ( P)2 (,)4.3 ( B)2 (er)-6 (r)-6 (u)10.6 (t)-6.6 (i)2.6 ( A)1.9 (,)4.3 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( C)2.6 (hem)-5.9 (o)10.5 (t)4.3 (her)-6 (apy)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h dac)-2 (ar)-6 (baz)8.9 (i)2.6 (ne )]TJ 0 -1.141 Td (and 5)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 2.826 0 Td [(f)-17.5 (l)2.6 (uo)10.5 (r)-5.9 (our)-6 (ac)-2 (i)2.6 (l)2.6 ( i)2.6 (n adv)19.8 (anc)-2 (ed m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )11.2 (c)-2 (anc)-2 (er)-6 (.)4.3 ( A)2 (nn )11.3 (O)-6.6 (nc)-2 (ol)2.6 ( )]TJ 0.002 Tw -2.826 -1.152 Td [(1994;)-6.6 (5:)-6.7 (763)]TJ 0 Tc 0 Tw 4.989 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(765.)4.2 ( )]TJ 0.007 Tw 2.217 0 Td [(A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)-8.3 (e at)4.2 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -7.543 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (7826911)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 303.84 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 301.8 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 280.2 Tm [(478.)-6.7 ( N)2.7 (oc)-2 (e)10.5 (r)-5.9 (a M)15.8 (,)-6.6 ( B)2 (audi)2.6 (n )11.3 (E)1.9 (,)-6.6 ( P)1.9 (el)2.6 (l)2.6 (egr)-5.9 (i)2.6 (t)-6.6 (i)2.6 ( )11.3 (G)-6.7 (,)4.3 ( et)4.2 ( al)2.6 (.)-6.6 ( )11.2 (Tr)-6 (e)10.5 (at)-6.7 (m)-5.9 (en)10.6 (t)-6.6 ( o)10.5 (f)-6.6 ( adv)8.8 (anc)-2 (ed )]TJ 0 -1.152 Td [(m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 ( w)13.5 (i)2.6 (t)-6.6 (h an al)2.6 (t)-6.6 (er)-6 (na)10.5 (t)-6.6 (i)2.6 (ng c)-2 (o)10.5 (m)-5.9 (b)10.5 (i)2.6 (nat)-6.6 (i)2.6 (on o)10.5 (f)-17.4 ( dox)8.8 (or)-6 (ubi)2.6 (c)-2 (i)2.7 (n)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 0 -1.141 Td [(s)-2 (t)-6.6 (r)-6 (ep)10.5 (t)-6.6 (oz)8.8 (oc)-2 (i)2.6 (n and 5 FU)]TJ 0 Tc 0 Tw 9.75 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(d)10.5 (ac)-2 (ar)-5.9 (baz)8.9 (i)2.6 (ne.)-6.6 ( G)4.2 (r)-5.9 (oupe d)10.5 (')-6.6 (E)1.9 (t)4.3 (ude des)-2 ( )11.3 (T)-10.6 (u)10.5 (m)-5.9 (eur)4.9 (s)-2 ( a)10.5 ( )]TJ -10.087 -1.152 Td [(C)2.6 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.6 (ne \()-6 (G)-6.6 (E)12.9 (T)-10.6 (C)2.6 (\))4.9 (.)-6.6 ( B)12.8 (r)-5.9 ( J)8.9 ( C)2.6 (anc)-2 (er)4.9 ( 2000;)-6.6 (83)10.5 (:)-6.6 (715)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 20.62 0 Td [(71)10.5 (8.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -20.62 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (10952773)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 229.56 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 227.52 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 205.92 Tm [(479.)-6.7 ( S)2 (c)-2 (hl)2.6 (um)-5.9 (be)10.6 (r)4.9 (g)-11.3 (er)4.9 ( M)15.8 (,)-6.6 ( A)12.8 (b)]TJ [(del)2.6 (m)-6 (oum)-5.9 (ene)10.5 ( N)2.6 (,)-6.6 ( D)2.6 (el)2.6 (i)2.6 (s)-2 (l)2.6 (e M)15.8 (J)-2 (,)-6.6 ( C)2.6 (ouet)-6.6 (t)-6.6 (e)10.5 ( J)-2 (E)2 (.)4.2 ( )]TJ 0 -1.141 Td [(T)-10.6 (r)-5.9 (e)10.5 (at)4.3 (m)-5.9 (ent)4.2 ( o)10.5 (f)-6.5 ( adv)8.9 (anc)-2 (ed )11.3 (m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 ( w)13.5 (i)2.6 (t)-6.6 (h an al)2.6 (t)-6.6 (er)-6 (na)10.5 (t)-6.6 (i)2.6 (ng )]TJ 0 -1.152 Td [(c)-2 (om)-6 (bi)2.7 (nat)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( 5)10.5 ( FU)]TJ 0 Tc 0 Tw 8.924 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(s)8.9 (t)-6.6 (r)-6 (e)10.5 (pt)-6.6 (oz)8.9 (oc)-2 (i)2.7 (n and 5 FU)]TJ 0 Tc 0 Tw 9.75 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(d)10.5 (ac)-2 (ar)5 (baz)8.9 (i)2.6 (ne.)-6.6 ( )-10.6 (T)-10.5 (he G)4.3 (r)-6 (oupe )]TJ 0.007 Tw -19.348 -1.141 Td [(d')-6.7 (E)2 (t)-6.7 (ude d)10.5 (es)-2 ( )11.3 (T)-10.6 (u)10.5 (m)-5.9 (eur)4.9 (s)-2 ( a)10.5 ( )11.3 (C)2.6 (al)2.6 (c)-2 (i)2.6 (t)-6.6 (oni)2.5 (ne \()-6 (G)-6.6 (E)12.8 (T)-10.5 (C)2.6 (\))4.9 (.)-6.6 ( B)12.8 (r)-6 ( J)8.9 ( C)2.6 (anc)-2 (er)4.9 ( 1995;)-6.6 (71)10.6 (:)-6.6 (363)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 0 -1.152 Td [(365.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.2 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.7 (h.)-6.6 (g)-11.2 (ov)8.9 (/)-6.6 (pu)10.5 (bm)-5.9 (ed/)-6.6 (7530987)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 715.08 155.28 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 492.6 153.24 222.48 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 131.64 Tm [(480.)-6.7 ( )11.3 (G)-6.6 (ul)2.6 (at)-6.6 (i)2.6 ( A)2 (P)1.9 (,)4.3 ( K)1.9 (r)-5.9 (an)10.6 (t)-6.6 (z)8.8 ( B)2 (,)4.3 ( M)15.8 (os)-2 (s)-2 ( R)2.6 (A)2 (,)-6.6 ( et)4.3 ( al)2.6 (.)4.3 ( )11.3 (T)-10.6 (r)-6 (ea)10.5 (t)-6.6 (m)-6 (e)10.6 (nt)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (m)-6 (ul)2.6 (t)-6.6 (i)2.6 (pl)2.6 (e endoc)-2 (r)-5.9 (i)2.6 (ne)10.6 ( )]TJ 0 -1.141 Td [(neopl)2.6 (as)-2 (i)2.6 (a 1/)-6.6 (2 )11.3 (t)-6.6 (um)-5.9 (o)10.5 (r)-5.9 (s)8.8 (:)-6.6 ( c)-2 (a)10.5 (s)-2 (e r)-6 (epo)10.5 (r)-6 (t)4.3 ( and )11.3 (r)-6 (ev)8.9 (i)2.6 (e)-11.2 (w)13.4 ( o)10.6 (f)-17.5 ( )11.2 (t)4.3 (he l)2.6 (i)2.6 (t)-6.6 (er)-6 (at)-6.6 (u)10.5 (r)-6 (e.)4.2 ( )11.3 (O)-6.6 (nc)-2 (ol)2.6 (o)10.5 (g)-11.2 (y)8.9 ( )]TJ 0.002 Tw 0 -1.152 Td [(2013;)-6.6 (84:)-6.6 (127)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(134.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -5.88 -1.141 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)6.6 (l)]TJ -0.002 Tc 0.002 Tw 7.804 0 Td [(m)-6 (.)-6.6 (ni)2.6 (h.)4.2 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (23235517)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 93.72 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 91.68 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 70.08 Tm [(481.)-6.7 ( S)2 (an)10.5 (t)-6.6 (ar)-5.9 (pi)2.6 (a L)10.5 (,)-6.6 ( Y)1.9 (e)10.6 ( L,)4.3 ( )11.3 (G)-6.7 (a)10.6 (g)-11.3 (el)2.6 ( R)2.6 (F.)4.3 ( B)1.9 (ey)8.9 (ond R)2.6 (E)2 (T:)-6.6 ( )11.3 (pot)-6.6 (ent)-6.7 (i)2.7 (al)2.6 ( t)-6.6 (he)10.5 (r)-6 (apeu)10.5 (t)-6.6 (i)2.6 (c)-2 ( )]TJ 0 -1.141 Td [(appr)-6 (oac)-2 (hes)-2 ( )11.3 (f)-6.6 (or)5 ( adv)8.9 (anc)-2 (ed and )11.3 (m)-6 (et)-6.6 (as)8.9 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (m)-6 (edul)2.6 (l)2.6 (ar)-5.9 (y)8.8 ( )0.5 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-6 (a.)4.3 ( J)-2 ( )]TJ EMC ET endstream endobj 1115 0 obj 27252 endobj %% Contents for page 132 %% Original object ID: 265 0 1116 0 obj << /Length 1117 0 R >> stream Q q BT /Xi130 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1117 0 obj 246 endobj %% Original object ID: 11984 0 1118 0 obj [ 3125 0 R 3126 0 R 3127 0 R 3128 0 R 3129 0 R 3130 0 R 3131 0 R 3132 0 R 3133 0 R 3134 0 R 3135 0 R 3136 0 R 3137 0 R 3138 0 R 3139 0 R 3140 0 R ] endobj %% Contents for page 133 %% Original object ID: 266 0 1119 0 obj << /Length 1120 0 R >> stream q endstream endobj 1120 0 obj 2 endobj %% Contents for page 133 %% Original object ID: 11985 0 1121 0 obj << /Length 1122 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (70)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(I)-6.6 (nt)-6.6 (e)10.6 (r)-6 (n M)15.7 (ed 2009;)-6.5 (266:)-6.6 (9)10.5 (9)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 10.913 0 Td [(113.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -10.913 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19522829)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 499.2 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 477.6 Tm [(482.)-6.7 ( C)2.7 (a)10.5 (k)-12.9 (i)2.6 (r)4.9 ( M)15.8 (,)-6.6 ( G)4.3 (r)-6 (os)-2 (s)8.8 (m)-5.9 (an )11.2 (A)2 (B)2 (.)-6.6 ( M)15.7 (edul)2.6 (l)2.6 (ar)-16.8 (y)8.8 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)-5.9 (:)4.3 ( m)-6 (ol)2.7 (ec)-2 (ul)2.6 (ar)5 ( bi)2.6 (ol)2.6 (og)-11.2 (y)8.9 ( )]TJ 0 -1.141 Td [(and nov)8.8 (el)2.6 ( m)-6 (ol)2.6 (ec)-1.9 (ul)2.6 (ar)-6 ( )11.3 (t)-6.6 (her)4.9 (api)2.6 (es)-2 (.)-6.7 ( N)2.7 (eur)-6 (oendoc)8.9 (r)-6 (i)2.6 (nol)2.6 (og)-11.2 (y)8.8 ( 2009;)-6.6 (90)10.5 (:)-6.6 (323)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 28.935 0 Td [(348)10.5 (.)-6.6 ( )]TJ 0.007 Tw -28.935 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (19468197)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 452.28 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 450.24 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 428.64 Tm [(483.)-6.7 ( C)2.7 (er)4.9 (r)-5.9 (at)-6.6 (o)10.5 ( A)2 (,)4.2 ( D)2.7 (e Fal)2.6 (c)-2 (o)10.5 ( V)2 (,)-6.7 ( S)2 (an)10.5 (t)-6.6 (or)-5.9 (o)10.5 ( M)15.8 (.)-6.6 ( M)15.7 (ol)2.6 (ec)-2 (ul)2.6 (ar)-16.8 ( )11.2 (g)-11.2 (enet)-6.7 (i)2.7 (c)-2 (s)8.8 ( o)10.6 (f)-6.7 ( m)-5.9 (edul)2.6 (l)2.7 (ar)-5.9 (y)8.8 ( )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a:)4.3 ( t)-6.6 (he)10.5 ( )11.2 (ques)-2 (t)-6.6 ( )11.3 (f)-6.6 (or)4.9 ( nov)8.9 (el)2.6 ( t)-6.6 (her)-6 (apeu)10.5 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (a)10.5 (r)4.9 (g)-11.2 (et)-6.7 (s)8.9 (.)-6.6 ( )11.3 (J)-2 ( M)15.8 (ol)2.6 ( )]TJ 0 -1.152 Td [(E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( 2009;)-6.6 (43)10.6 (:)-6.6 (143)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 10.859 0 Td [(155.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.7 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -10.859 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19383830)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 390.72 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 388.68 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 367.08 Tm [(484.)-6.7 ( C)2.7 (hat)-6.7 (al)13.5 ( J)-2 (F,)4.2 ( C)2.7 (am)-5.9 (pi)2.6 (on)10.5 ( L,)4.3 ( K)2 (r)-6 (aeber)]TJ 0 Tc 0 Tw 15.957 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(B)2 (oder)-5.9 (e)10.5 ( F,)4.2 ( et)4.3 ( )11.2 (al)2.6 (.)-6.6 ( S)1.9 (ur)-6 (v)8.9 (i)2.6 (v)8.9 (al)2.7 ( )]TJ -16.293 -1.152 Td [(i)2.6 (m)-5.9 (pr)-6 (ov)8.9 (em)-5.9 (ent)4.2 ( i)2.7 (n pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 (s)-2 ( )11.2 (w)2.6 (i)2.7 (t)-6.7 (h m)-6 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (a)10.5 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a )0.5 (w)13.4 (ho under)5 (g)-11.3 (o)10.6 ( )]TJ 0 -1.141 Td [(pr)-6 (et)-6.6 (a)10.6 (r)4.9 (g)-11.2 (et)-6.6 (ed)10.5 ( ant)-6.6 (i)]TJ 0 Tc 0 Tw 6.989 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (noe)10.5 (m)-5.9 (br)-5.9 (y)8.8 (oni)2.6 (c)]TJ 0 Tc 0 Tw 7.793 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(ant)-6.6 (i)13.5 (g)-11.2 (en)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 3.543 0 Td [(r)-6 (adi)2.7 (oi)2.6 (m)-5.9 (m)-6 (uno)10.5 (t)-6.6 (her)-5.9 (apy)8.9 (:)4.2 ( a )]TJ -19 -1.141 Td [(c)-2 (ol)2.6 (l)2.6 (abor)-5.9 (at)-6.6 (i)2.6 (v)8.9 (e s)-2 (t)-6.5 (udy)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h t)-6.6 (he Fr)-5.9 (enc)-2 (h)10.5 ( E)2 (ndoc)-2 (r)-5.9 (i)2.6 (ne)10.6 ( )11.2 (T)-10.5 (u)10.5 (m)-6 (or)4.9 ( G)4.3 (r)-6 (oup.)4.2 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n O)-6.6 (nc)-2 (ol)2.6 ( )]TJ 0.002 Tw 0 -1.152 Td [(2006;)-6.6 (24:)-6.6 (1705)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1711.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (16549819)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 303.84 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 301.8 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 280.2 Tm [(485.)-6.7 ( S)2 (al)2.6 (aun P)2 (Y)1.9 (,)4.3 ( C)2.6 (am)-6 (pi)2.6 (o)10.5 (n)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 11.75 0 Td [(L,)4.2 ( B)2 (our)-6 (naud)10.5 ( C)2.6 (,)-6.6 ( e)10.5 (t)4.3 ( al)2.6 (.)-6.6 ( P)12.8 (has)-2 (e I)4.3 (I)-6.6 ( )11.2 (t)-6.6 (r)-5.9 (i)2.6 (al)2.7 ( o)10.6 (f)-6.7 ( )]TJ -11.75 -1.152 Td [(ant)-6.6 (i)2.6 (c)-2 (ar)-6 (c)-2 (i)2.6 (noem)-6 (b)10.6 (r)-6 (y)8.9 (oni)2.6 (c)-2 ( ant)4.2 (i)2.6 (g)-11.2 (en p)10.6 (r)-6 (et)-6.7 (a)10.6 (r)4.9 (g)-11.2 (et)-6.6 (ed)10.5 ( r)-6 (adi)2.7 (oi)2.6 (m)4.9 (m)-5.9 (unot)-6.6 (he)10.5 (r)-6 (apy)8.8 ( i)2.6 (n )]TJ 0 -1.141 Td [(pr)-6 (o)10.5 (g)-11.2 (r)-5.9 (es)-2 (s)-2 (i)2.6 (v)8.9 (e m)-5.9 (e)10.5 (t)-6.6 (as)8.9 (t)-6.6 (at)-6.6 (i)2.6 (c)-2 ( )11.2 (m)4.9 (edul)2.6 (l)2.6 (ar)-6 (y)8.9 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a:)-6.6 ( bi)2.6 (om)-6 (a)10.5 (r)4.9 (k)-12.8 (e)10.5 (r)-6 ( )11.3 (r)-6 (es)-2 (pons)-2 (e )]TJ 0 -1.152 Td [(and s)-2 (ur)-5.9 (v)8.8 (i)2.6 (v)8.9 (al)2.6 ( i)2.6 (m)-6 (pr)-6 (ov)8.8 (em)-6 (ent)-6.6 (.)4.3 ( J)-2 ( N)2.6 (uc)-2 (l)2.6 ( M)15.8 (ed )0.5 (2012;)-6.6 (53)10.5 (:)-6.6 (11)10.5 (85)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 23.598 0 Td [(1192.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -23.598 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22743249)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 229.56 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 227.52 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 205.92 Tm [(486.)-6.7 ( A)2 (r)-6 (e)10.6 ( C)2.6 (,)4.2 ( S)2 (haha A)2 (R)2.6 (.)4.2 ( A)12.8 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2.1 (a)10.6 (r)-6 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (a:)4.3 ( bi)2.6 (ol)2.6 (og)-11.2 (y)8.9 (,)-6.6 ( )]TJ 0 -1.141 Td [(pat)-6.6 (ho)10.6 (g)-11.2 (enes)-2 (i)2.6 (s)-2 (,)4.3 ( pr)-5.9 (o)10.5 (g)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)8.8 ( )11.3 (f)-17.5 (ac)8.9 (t)-6.7 (or)-6 (s)8.9 (,)-6.6 ( a)10.5 (nd )11.3 (t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( a)10.5 (ppr)-5.9 (oac)-2 (hes)-2 (.)4.3 ( A)1.9 (nn S)2 (u)10.5 (r)4.9 (g)-11.2 ( )]TJ 0 -1.152 Td [(O)-6.6 (nc)-2 (ol)2.6 ( 2006)10.5 (;)-6.6 (13:)-6.6 (453)]TJ 0 Tc 0 Tw 8.424 0 Td (-)Tj -0.002 Tc -0.004 Tw 0.337 0 Td [(464.)4.2 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -8.761 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (p)]TJ [(ubm)-5.9 (ed/)-6.6 (16474910)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 168 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 165.96 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 144.36 Tm [(487.)-6.7 ( K)2 (ebebew)13.4 ( E)2 (,)-6.6 ( )11.3 (G)-6.6 (r)-6 (een)10.5 (s)-2 (pan FS)1.9 (,)4.3 ( C)2.6 (l)2.6 (ar)4.9 (k)-12.9 ( )11.3 (O)-6.6 (H)2.6 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( A)2 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d )]TJ 0 -1.152 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( )11.3 (Tr)-6 (eat)4.3 (m)-6 (ent)4.3 ( ou)10.5 (t)-6.6 (c)-2 (om)-6 (e)10.6 ( and p)10.5 (r)-5.9 (o)10.5 (g)-11.2 (nos)8.9 (t)-6.6 (i)2.6 (c)-2 ( )11.2 (f)-6.6 (a)10.5 (c)-2 (t)-6.6 (or)-6 (s)8.9 (.)-6.6 ( C)2.6 (anc)-2 (e)10.5 (r)-5.9 ( )]TJ 0.002 Tw 0 -1.141 Td [(2005;)-6.6 (103:)-6.6 (1330)]TJ 0 Tc 0 Tw 6.652 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1335.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -6.989 -1.152 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)6.6 (l)9.6 (m)1.1 (.)]TJ -0.002 Tc 0.002 Tw [(ni)2.6 (h.)4.3 (gov)8.8 (/)-6.6 (pubm)-6 (ed/)-6.6 (15739211)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 106.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 104.28 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 82.68 Tm [(488.)-6.7 ( S)12.9 (m)-6 (al)2.6 (l)2.6 (r)-6 (i)2.7 (dg)-11.2 (e)10.5 ( R)2.6 (C)2.6 (,)-6.6 ( A)2 (i)2.6 (n )11.3 (K)1.9 (B)2 (,)-6.6 ( A)2 (s)-2 (a S)2 (L)10.5 (,)-6.6 ( e)10.5 (t)-6.6 ( al)13.5 (.)-6.6 ( A)12.8 (m)-5.9 (er)-5.9 (i)13.5 (c)-2 (an )11.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d A)2 (s)-2 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (i)2.6 (on )]TJ 0 -1.141 Td [(g)-11.2 (ui)2.6 (del)2.6 (i)2.6 (nes)-2 ( )11.3 (f)-17.5 (o)10.5 (r)-6 ( )11.3 (m)-5.9 (ana)10.5 (g)-11.2 (e)10.5 (m)4.9 (ent)-6.6 ( o)10.5 (f)-6.6 ( pa)10.5 (t)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( )0.5 (w)13.4 (i)2.6 (t)-6.6 (h anapl)2.6 (as)-2 (t)-6.7 (i)2.7 (c)-2 ( )11.2 (t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d c)-2 (anc)-2 (er)4.9 (.)-6.6 ( )]TJ 0 -1.141 Td [(T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d 2012;)-6.6 (22)10.5 (:)-6.6 (1104)]TJ 0 Tc 0 Tw 9.696 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1)10.5 (139.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -10.033 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (23130564)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 44.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 42.72 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(489.)-6.7 ( M)15.8 (or)-6 (et)-6.6 (t)-6.6 (i)2.6 ( F)11.1 (,)4.3 ( Far)-6 (s)-2 (e)10.5 (t)-6.6 (t)-6.6 (i)2.6 ( A)12.9 (,)-6.7 ( S)2 (oddu)10.6 ( S)1.9 (,)-6.6 ( e)10.5 (t)-6.6 ( )11.3 (al)2.6 (.)-6.6 ( p53)10.5 ( r)-6 (e)]TJ 0 Tc 0 Tw 21.163 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(e)10.5 (x)8.9 (pr)-5.9 (es)-2 (s)-2 (i)2.7 (on i)2.6 (nhi)2.6 (bi)2.7 (t)-6.7 (s)-2 ( )]TJ -21.5 -1.152 Td [(pr)-6 (ol)2.7 (i)2.6 (f)-17.5 (e)10.5 (r)-5.9 (at)-6.6 (i)2.6 (on)10.5 ( and )11.3 (r)-5.9 (es)-2 (t)-6.6 (o)10.5 (r)-5.9 (es)8.9 ( di)13.4 (f)-6.6 (f)-17.5 (e)10.6 (r)-6 (ent)-6.6 (i)2.6 (at)-6.6 (i)2.6 (on)10.6 ( o)10.6 (f)-6.6 ( hum)-6 (an)10.5 ( )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( )]TJ 0 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( c)-2 (el)2.6 (l)2.7 (s)-2.1 (.)-6.5 ( )11.2 (O)-6.6 (nc)-2 (o)10.5 (g)-11.2 (e)10.5 (ne 1997;)-6.6 (14)10.6 (:)-6.6 (729)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 18.185 0 Td [(740)10.5 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -18.185 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9038381)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 473.88 222.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 452.28 Tm [(490.)-6.7 ( M)15.8 (aat)-6.6 (ouk)-2 ( J)8.9 (,)-6.6 ( B)1.9 (a)10.6 (r)4.9 (k)-12.9 (l)2.6 (ow)2.6 ( )11.3 (T)-10.6 (A)2 (,)-6.7 ( Za)10.5 (k)-2 (ar)-5.9 (i)2.6 (a )33 (W)-36.2 (,)4.2 ( )11.3 (A)2 (l)]TJ 0 Tc 0 Tw 19 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(A)2 (bba)10.5 (di)2.7 ( M)15.7 (A)2 (.)-6.6 ( A)1.9 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ -19.337 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( ar)-5.9 (i)2.6 (s)-2 (i)2.6 (n)10.5 (g)-11.2 ( i)2.6 (n l)2.6 (on)10.6 (g)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 11.359 0 Td [(s)-2 (t)-6.6 (andi)2.7 (n)10.5 (g)-11.2 ( m)-5.9 (ul)2.6 (t)-6.6 (i)2.6 (nodul)2.6 (ar)4.9 ( goi)2.6 (t)-6.6 (er)-6 ( f)-6.6 (ol)2.6 (l)2.6 (ow)2.6 (i)2.6 (ng)-11.3 ( )-10.6 (r)-5.9 (a)10.5 (di)2.6 (oac)-2 (t)-6.6 (i)2.6 (v)8.8 (e )]TJ 0.002 Tw -11.359 -1.152 Td [(i)2.6 (odi)]TJ 0.007 Tw 1.543 0 Td [(ne t)-6.6 (her)-5.9 (apy)8.9 (:)-6.6 ( )11.3 (r)-6 (epor)4.9 (t)-6.6 ( o)10.5 (f)-6.6 ( )11.3 (a c)-2 (as)-2 (e di)2.6 (a)10.5 (g)-11.2 (nos)-2 (ed)10.5 ( by)8.9 ( )11.3 (f)-17.5 (i)2.6 (ne)10.6 ( needl)2.6 (e as)-2 (pi)2.7 (r)-6 (a)10.5 (t)-6.6 (i)2.6 (on.)-6.6 ( A)2 (c)8.9 (t)-6.7 (a )]TJ -1.543 -1.141 Td [(C)2.6 (y)8.9 (t)-6.6 (ol)2.6 ( 2009;)-6.6 (53:)-6.6 (581)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 8.435 0 Td [(583)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e )-10.6 (at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -8.435 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19798888)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 401.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 399.72 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 378 Tm [(491.)-6.7 ( A)2 (l)2.6 (di)2.6 (ng)-11.2 (e)10.5 (r)-5.9 ( K)1.9 (A)12.9 (,)-6.6 ( S)2 (a)10.5 (m)-5.9 (a)10.5 (an N)2.6 (A)2 (,)-6.6 ( )11.2 (I)-6.6 (banez)8.9 ( M)15.8 (,)-6.6 ( H)2.6 (i)2.6 (l)2.6 (l)]TJ 0 Tc 0 Tw 19.978 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(C)2.6 (S)-8.9 (,)-6.6 ( J)8.9 (r)-6 (.)4.3 ( A)1.9 (napl)2.6 (as)-2 (t)-6.6 (i)2.7 (c)-2 ( )]TJ -20.261 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.6 ( t)-6.5 (hy)8.9 (r)-6 (oi)2.6 (d:)4.3 ( a )11.3 (r)-6 (ev)8.9 (i)2.6 (e)-11.2 (w)13.4 ( of)-6.6 ( 84 c)8.9 (as)-2 (es)-2 ( o)10.5 (f)-6.6 ( )11.3 (s)-2 (pi)2.6 (ndl)2.6 (e and )11.3 (g)-11.2 (i)2.6 (ant)-6.6 ( c)8.9 (el)2.6 (l)2.6 ( )]TJ 0 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.6 ( t)-6.5 (hy)8.9 (r)-6 (oi)2.6 (d.)4.3 ( C)2.6 (anc)-2 (er)4.9 ( 1978;)-6.6 (41)10.6 (:)-6.7 (2267)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 21.12 0 Td [(2)10.5 (275.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -21.12 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (6570)]TJ (91)Tj EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 621.48 340.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 338.04 216.48 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 316.44 Tm [(492.)-6.7 ( K)2 (eu)10.5 (t)4.2 (g)-11.2 (en )11.3 (X)-8.9 (M)15.8 (,)-6.6 ( S)1.9 (ado)10.5 (w)13.5 (s)-2 (k)-12.8 (i)2.6 ( S)1.9 (M)15.8 (,)-6.6 ( K)2 (ebebew)13.5 ( E)2 (.)-6.7 ( M)5 (anag)-11.2 (e)10.5 (m)-5.9 (ent)4.2 ( o)10.5 (f)-6.6 ( anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)8.9 ( )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (er)5 (.)-6.7 ( )11.3 (G)-6.6 (l)2.6 (and S)1.9 (u)10.6 (r)-6 (g 2015)10.5 (;)-6.6 (4:)-6.6 (44)]TJ 0 Tc 0 Tw 16.565 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(51.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)-8.3 (e at)4.3 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -16.902 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (25713779)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 291.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 289.08 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 267.48 Tm [(493.)-6.7 ( S)2 (her)4.9 (m)-5.9 (an)10.6 ( S)2 (I)4.3 (.)-6.6 ( A)2 (napl)13.4 (as)-2 (t)-6.6 (i)]TJ 12.13 0 Td [(c)-2 ( c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.5 (:)-6.6 ( C)2.6 (l)2.7 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( as)-2.1 (pec)-2 (t)-6.6 (s)8.9 (.)-6.6 ( )11.3 (I)-6.6 (n:)4.3 ( )22.1 (W)-36.2 (a)10.5 (r)4.9 (t)-6.6 (o)10.5 (f)-6.6 (s)8.9 (k)-12.9 (y)8.9 ( L,)4.3 ( )]TJ -12.13 -1.141 Td [(V)2 (an N)2.6 (os)-2 (t)-6.6 (r)-5.9 (and)10.5 ( D)2.6 (,)4.3 ( eds)8.8 (.)-6.6 ( )11.3 (T)-10.6 (h)10.6 (y)8.8 (r)-5.9 (oi)2.6 (d C)2.6 (anc)-2 (er)-6 (:)-6.6 ( A)12.8 ( C)2.6 (om)-6 (p)10.5 (r)-5.9 (e)10.5 (hens)-2 (i)2.6 (v)8.8 (e G)-6.6 (ui)2.7 (de )0.5 (t)-6.7 (o)10.6 ( C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)-8.3 ( )]TJ 0 -1.152 Td [(M)15.8 (anag)-11.2 (em)-6 (ent)-6.6 (,)4.3 ( 2nd)10.5 ( ed.)4.3 ( )11.2 (Tot)-6.6 (ow)13.4 (a,)-6.6 ( N)2.6 (J)-2 (:)-6.6 ( H)2.6 (u)10.5 (m)-5.9 (ana P)12.8 (r)-5.9 (es)8.9 (s)-2 (;)-6.6 ( 2006)10.6 (:)-6.6 (629)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 27.207 0 Td [(632)10.5 (.)]TJ 0 Tc 0 Tw 1.924 0 Td ( )Tj EMC /P <>BDC -0.002 Tc 0.007 Tw -29.13 -2.141 Td [(494.)-6.7 ( )11.3 (T)-10.5 (a)10.5 (k)-12.9 (as)-2 (hi)13.5 (m)-6 (a S)12.8 (,)-6.6 ( M)15.8 (or)-5.9 (i)2.6 (m)-6 (ot)-6.6 (o)10.5 ( S)2 (,)4.2 ( I)4.3 (k)-12.9 (ez)8.8 (oe J)8.9 (,)-6.6 ( e)10.5 (t)-6.6 ( al)13.4 (.)-6.6 ( )11.3 (C)2.6 (T)-10.6 ( ev)8.9 (al)2.6 (uat)-6.6 (i)2.6 (on )0.5 (o)10.5 (f)-6.6 ( )]TJ 0 -1.141 Td [(anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (h)]TJ [(y)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (n)10.6 (om)-6 (a.)4.3 ( A)1.9 (J)-2 (R)2.6 ( A)12.9 (m)-6 ( J)8.9 ( R)2.6 (oent)4.3 (g)-11.2 (e)10.5 (nol)2.6 ( 1990;)-6.6 (154:)-6.6 (1079)]TJ 0 Tc 0 Tw 29.913 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(1085.)4.3 ( )]TJ 0.007 Tw -30.25 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (2108546)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 690.6 193.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 191.28 222.48 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 169.68 Tm [(495.)-6.7 ( N)2.7 (e)10.5 (f)-6.6 (f)-6.6 ( R)2.6 (L)10.5 (,)-6.6 ( Fa)10.5 (r)-6 (r)-5.9 (a)10.5 (r)-5.9 ( )33 (W)-36.3 (B)12.8 (,)4.3 ( K)2 (l)2.6 (oos)-2 ( R)13.5 (T)-10.6 (,)4.3 ( B)2 (ur)4.9 (m)-6 (an K)2 (D)2.6 (.)4.2 ( )11.3 (A)2 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (anc)-2 (er)-6 (.)4.3 ( E)1.9 (ndoc)-2 (r)-6 (i)2.6 (no)]TJ [(l)2.6 ( M)15.8 (et)-6.6 (ab C)2.6 (l)2.6 (i)2.6 (n N)2.6 (or)-5.9 (t)-6.6 (h)10.5 ( A)1.9 (m)5 ( 2008;)-6.7 (37)10.5 (:)-6.6 (525)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 23.946 0 Td [(538)10.5 (,)-6.6 ( x)8.9 (i)2.6 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -23.946 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (18502341)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 144.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 142.32 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 120.72 Tm [(496.)-6.7 ( )33.1 (W)-36.3 (ei)2.7 (n)10.5 ( R)2.6 (O)4.2 (,)-6.6 ( )33.1 (W)-36.3 (e)10.5 (ber)4.9 ( R)13.5 (S)2 (.)-6.6 ( A)1.9 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (a)10.5 (r)4.9 (c)-2 (i)2.6 (nom)-5.9 (a:)4.3 ( pal)2.6 (l)2.6 (i)2.6 (at)-6.6 (i)2.6 (on or)-5.9 ( )]TJ 0 -1.152 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 (? C)2.6 (u)10.5 (r)-6 (r)5 ( O)-6.7 (pi)2.6 (n )11.2 (O)4.3 (t)4.3 (ol)2.6 (a)]TJ [(r)-6 (y)8.9 (ng)-11.2 (ol)2.6 ( H)2.6 (ead N)2.6 (ec)8.9 (k)-2 ( S)1.9 (ur)4.9 (g )0.5 (2011;)-6.6 (19)10.5 (:)-6.6 (113)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 28.478 0 Td [(118)10.5 (.)-6.6 ( )]TJ 0.007 Tw -28.478 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (21252667)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 95.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 93.36 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 71.76 Tm [(497.)-6.7 ( U)2.7 (nt)4.3 (c)-2 (h B)2 (R)2.6 (,)4.2 ( )11.3 (O)-6.6 (l)2.6 (s)-2 (on J)-2 (A)12.9 (,)-6.7 ( J)8.9 (r)-5.9 (.)4.2 ( A)2 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)8.9 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a,)4.3 ( )11.3 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.152 Td [(l)2.6 (y)8.9 (m)-6 (phom)-6 (a,)-6.6 ( and)10.5 ( m)-6 (e)10.6 (t)-6.6 (as)8.9 (t)-6.6 (a)10.5 (s)-2 (i)2.6 (s)-2 ( t)-6.6 (o)10.5 ( t)-6.6 (hy)]TJ 14.565 0 Td [(r)-6 (oi)2.6 (d.)-6.6 ( S)1.9 (u)10.5 (r)4.9 (g)-11.2 ( )11.3 (O)-6.6 (nc)-2 (o)10.6 (l)2.6 ( C)2.6 (l)2.6 (i)2.6 (n N)2.7 ( A)1.9 (m)-5.9 ( 2006)10.5 (;)-6.6 (15:)-6.6 (661)]TJ 0 Tc 0 Tw 17.783 0 Td (-)Tj -0.002 Tc 0.007 Tw -32.348 -1.141 Td [(679,)-6.7 ( x)8.9 (.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)4.3 (t)-6.6 (p:)4.3 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.4 (.)-6.5 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)-6.6 (g)-11.2 (ov)8.9 (/)-6.6 (p)10.5 (ubm)-6 (ed/)-6.6 (16882503)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 732.84 46.44 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 504.24 44.4 228.6 0.841 re f EMC endstream endobj 1122 0 obj 27697 endobj %% Contents for page 133 %% Original object ID: 267 0 1123 0 obj << /Length 1124 0 R >> stream Q q BT /Xi131 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1124 0 obj 246 endobj %% Original object ID: 12003 0 1125 0 obj [ 3141 0 R 3142 0 R 3143 0 R 3144 0 R 3145 0 R 3146 0 R 3147 0 R 3148 0 R 3149 0 R 3150 0 R 3151 0 R 3152 0 R 3153 0 R 3154 0 R 3155 0 R 3156 0 R ] endobj %% Contents for page 134 %% Original object ID: 268 0 1126 0 obj << /Length 1127 0 R >> stream q endstream endobj 1127 0 obj 2 endobj %% Contents for page 134 %% Original object ID: 12004 0 1128 0 obj << /Length 1129 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (71)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(498.)-6.7 ( S)2 (haha)10.5 ( A)1.9 (R)2.7 (.)-6.7 ( A)2 (i)2.6 (r)-6 (w)13.5 (ay)8.8 ( m)-5.9 (ana)10.5 (g)-11.2 (em)-6 (en)10.5 (t)-6.6 ( i)2.6 (n)10.5 ( anapl)2.6 (as)-2 (t)4.2 (i)2.6 (c)-2 ( )0.5 (t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)4.9 (c)-2 (i)2.6 (nom)-5.9 (a.)4.3 ( )]TJ 0 -1.152 Td [(Lar)-6 (y)8.9 (ng)-11.2 (os)-2 (c)-2 (ope)10.5 ( 2008;)-6.6 (118)10.5 (:)4.2 (11)]TJ 0.002 Tw (95)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 13.522 0 Td [(1198.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -13.522 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (18438260)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 488.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 486.6 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 465 Tm [(499.)-6.7 ( V)2 (en)10.5 (k)-12.9 (a)10.5 (t)-6.6 (es)-2 (h Y)2 (S)12.8 (,)-6.6 ( )11.3 (O)-6.6 (r)-6 (d)10.5 (onez)8.9 ( N)2.6 (G)-6.6 (,)-6.6 ( S)2 (c)-2 (hul)2.6 (t)-6.6 (z)8.9 ( P)1.9 (N)2.7 (,)4.2 ( et)4.2 ( )11.3 (al)2.7 (.)-6.7 ( )0.5 (A)1.9 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( c)-2 (a)10.5 (r)-5.9 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( )]TJ 0 -1.152 Td [(o)10.5 (f)-17.5 ( )11.3 (t)-6.6 (he )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d.)-6.6 ( A)2 ( )11.3 (c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (opat)-6.6 (hol)2.6 (og)-11.3 (i)2.7 (c)8.8 ( s)-2 (t)-6.6 (udy)8.9 ( o)10.5 (f)-6.6 ( 121)10.5 ( c)-2 (a)10.6 (s)-2 (es)-2 (.)-6.6 ( C)]TJ 0.002 Tw 24.435 0 Td [(anc)-2 (e)10.5 (r)-5.9 ( )]TJ -24.435 -1.141 Td [(1990;)-6.6 (66:)-6.6 (321)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(330.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.7 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (1695118)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 246.12 426.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 424.92 222.601 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 403.32 Tm [(500.)-6.7 ( S)2 (u)10.5 (g)-11.2 (i)2.6 (t)-6.6 (ani)2.6 ( )11.3 (I)-6.6 (,)4.3 ( M)15.7 (i)-8.2 (y)8.8 (auc)-2 (hi)-8.3 ( A)2 (,)-6.6 ( S)1.9 (u)10.6 (g)-11.2 (i)2.6 (no)10.5 ( K)2 (,)-6.6 ( e)10.5 (t)4.3 ( al)2.6 (.)-6.6 ( P)12.8 (r)-5.9 (o)10.5 (gnos)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.2 (f)-6.6 (ac)-2 (t)-6.6 (o)10.5 (r)-6 (s)-2 ( an)10.5 (d )]TJ 0 -1.141 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( ou)10.5 (t)-6.6 (c)-2 (o)10.5 (m)-5.9 (es)-2 ( )11.3 (f)-6.6 (or)4.9 ( a)10.5 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2.1 (a)10.6 (r)-6 (c)-2 (i)2.6 (no)10.5 (m)-6 (a:)4.3 ( A)12.8 (T)-10.6 (C)2.6 ( R)2.6 (es)-2 (ear)4.9 (c)-2 (h )]TJ 0 -1.152 Td [(C)2.6 (ons)-2 (or)-6 (t)-6.6 (i)2.6 (um)4.9 ( o)10.5 (f)-6.6 ( J)-2 (apan)10.5 ( c)-2 (oh)10.5 (or)-6 (t)4.3 ( s)-2 (t)-6.6 (udy)8.9 ( o)10.5 (f)-6.6 ( 677)10.5 ( pat)-6.6 (i)2.6 (ent)4.3 (s)-2 (.)4.2 ( )22.2 (W)-36.3 (o)10.5 (r)-5.9 (l)2.6 (d)10.5 ( J)-2 ( S)2 (u)10.5 (r)4.9 (g)-11.2 ( )]TJ 0.002 Tw 0 -1.141 Td [(2012;)-6.6 (36:)-6.6 (1247)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1254.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22311136)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 350.76 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 329.16 Tm [(501.)-6.7 ( A)12.9 (k)-12.9 (ai)2.6 (s)-2 (hi)2.6 ( J)8.9 (,)-6.6 ( S)1.9 (u)10.6 (g)-11.3 (i)2.7 (no K)12.8 (,)4.2 ( K)2 (i)2.6 (t)-6.6 (a)10.5 (g)-11.2 (aw)13.5 (a )22.1 (W)-36.2 (,)4.2 ( e)10.6 (t)4.2 ( al)2.6 (.)-6.6 ( P)12.8 (r)-5.9 (o)10.5 (gnos)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (f)-6.6 (ac)-2 (t)-6.6 (o)10.6 (r)-6 (s)-2 ( an)10.5 (d )]TJ 0 -1.152 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( ou)10.5 (t)-6.6 (c)-2 (o)10.5 (m)-5.9 (es)-2 ( o)10.5 (f)-6.6 ( 1)10.5 (00 c)-2 (as)-2 (es)8.8 ( o)10.5 (f)-6.6 ( anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (t)-6.6 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a.)4.3 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ 0.002 Tw 0 -1.141 Td [(2011;)-6.6 (21:)-6.6 (1183)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1189.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21936674)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 291.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 289.08 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 267.48 Tm [(502.)-6.7 ( M)15.8 (ani)2.7 ( N)2.5 (,)-6.5 ( M)15.7 (c)-2 (N)2.6 (am)-6 (ar)-6 (a )11.2 (K)2 (,)-6.6 ( Low)13.5 (e N)2.7 (,)-6.7 ( e)10.6 (t)-6.7 ( al)2.6 (.)4.3 ( M)15.8 (anagem)-5.9 (ent)4.2 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.5 ( )]TJ 0 -1.141 Td [(c)-2 (om)-6 (pr)-5.9 (o)10.5 (m)-5.9 (i)2.6 (s)-2 (ed ai)2.6 (r)-5.9 (w)13.5 (ay)8.9 ( and r)-5.9 (ol)2.6 (e o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (r)-6 (ac)-2 (heo)10.5 (t)-6.6 (o)10.5 (m)-5.9 (y)8.8 ( i)2.6 (n a)10.5 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d )]TJ 0 -1.152 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( H)2.6 (ead)10.5 ( N)2.6 (ec)8.8 (k)-12.8 ( 2)10.5 (016;)-6.6 (38:)-6.7 (8)]TJ 0 Tc 0 Tw (5)Tj 15.348 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(88.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e )-10.4 (at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -15.685 -1.141 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (25215461)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 257.76 229.56 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 227.52 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 205.92 Tm [(503.)-6.7 ( J)-2 (uno)10.6 (r)-6 ( E)2 (J)8.8 (,)-6.6 ( P)2 (aul)2.6 ( )11.3 (J)-2 (,)4.2 ( R)2.6 (eed N)2.6 (S)2 (.)-6.6 ( A)1.9 (napl)2.6 (as)8.9 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.8 (r)-5.9 (o)10.5 (i)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a)10.5 (:)-6.6 ( 91)10.5 ( pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 (s)8.8 ( )]TJ 0 -1.141 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (ed by)8.8 ( s)-2 (ur)4.9 (ger)-5.9 (y)8.8 ( and )11.2 (r)4.9 (adi)2.6 (ot)-6.6 (her)-5.9 (apy)8.8 (.)-6.6 ( E)2 (ur)5 ( J)8.8 ( S)2 (ur)5 (g)-11.3 ( )11.3 (O)-6.6 (nc)-2 (ol)2.6 ( 1)]TJ 0.002 Tw [(992)10.5 (;)-6.6 (18:)-6.6 (83)]TJ 0 Tc 0 Tw 29.196 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(88.)4.3 ( )]TJ 0.007 Tw -29.533 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (1582515)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 309.12 180.6 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 178.56 222.48 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 156.96 Tm [(504.)-6.7 ( M)15.8 (c)-2 (I)-6.6 (v)8.9 (er)-5.9 ( B)1.9 (,)4.3 ( H)2.6 (ay)8.8 ( I)-6.6 (D)2.6 (,)-6.6 ( )11.3 (G)4.3 (i)2.6 (uf)-6.6 (f)-6.6 (r)-6 (i)2.7 (da D)2.6 (F)11.2 (,)-6.7 ( e)10.6 (t)-6.7 ( al)2.6 (.)4.3 ( A)1.9 (napl)2.6 (a)10.5 (s)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (no)10.5 (m)-5.9 (a:)4.3 ( a )]TJ 0.002 Tw 0 -1.141 Td (50)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 1.446 0 Td [(y)8.9 (ear)-6 ( ex)8.8 (per)-5.9 (i)2.6 (enc)-2 (e at)4.3 ( a )11.3 (s)-2 (i)2.6 (ng)-11.2 (l)2.6 (e i)2.6 (ns)-2 (t)-6.7 (i)13.5 (t)-6.6 (ut)-6.6 (i)2.6 (on.)4.2 ( S)2 (ur)4.9 (g)-11.3 (e)]TJ 19.609 0 Td [(r)4.9 (y)8.9 ( 2001;)-6.6 (130:)-6.6 (1028)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 8.098 0 Td [(1034)10.5 (.)4.2 ( )]TJ 0.007 Tw -29.152 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (11742333)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 131.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 129.6 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 108 Tm [(505.)-6.7 ( S)2 (t)4.3 (av)8.9 (as)-1.9 ( M)15.8 (J)-2 (,)-6.6 ( S)2 (hi)2.6 (nohar)-5.9 (a E)12.9 (T)-10.6 (,)4.3 ( A)1.9 (t)4.3 (t)-6.6 (i)2.6 (a A)2 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( S)2 (hor)5 (t)-6.7 ( )0.5 (c)-2 (ou)10.5 (r)-5.9 (s)-2 (e hi)13.5 (g)-11.3 (h)10.6 ( dos)-2 (e )]TJ 0 -1.141 Td [(r)-6 (adi)2.7 (ot)-6.6 (her)-5.9 (apy)8.8 ( i)2.6 (n )11.3 (t)-6.6 (he )11.2 (t)-6.6 (r)-5.9 (ea)10.5 (t)4.3 (m)-6 (ent)4.2 ( o)10.5 (f)-6.6 ( anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)8.9 ( t)]TJ 19.174 0 Td [(hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (no)10.6 (m)-6 (a.)4.2 ( J)-2 ( )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ -19.174 -1.152 Td [(R)2.6 (es)-2 ( 2014;)-6.6 (2014)10.6 (:)-6.7 (764281.)4.2 ( )11.3 (A)1.9 (v)8.9 (ai)-8.3 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 0 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (25379320)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 70.08 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 68.04 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(506.)-6.7 ( D)2.7 (u)10.5 (m)4.9 (k)-12.9 (e A)1.9 (K)2 (,)4.2 ( P)2 (el)2.6 (z)8.8 ( T,)-6.7 ( )11.3 (V)2 (or)-5.9 (der)-6 (m)-6 (a)10.6 (r)4.9 (k)-2 ( D)2.6 (.)4.3 ( Lon)10.5 (g)]TJ 0 Tc 0 Tw 19.891 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(t)-6.6 (er)5 (m)-6 ( )11.3 (r)-6 (es)-2 (ul)2.6 (t)-6.6 (s)8.9 ( o)10.5 (f)-6.6 ( r)-6 (adi)2.7 (ot)-6.6 (he)10.5 (r)-6 (apy)8.9 ( )]TJ -20.217 -1.152 Td [(i)2.6 (n anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (h)]TJ [(y)8.9 (r)-6 (oi)2.7 (d c)-2 (an)10.5 (c)-2 (er)-5.9 (.)4.2 ( )0.5 (R)2.6 (adi)2.6 (at)-6.6 ( )11.3 (O)-6.6 (nc)-2 (ol)2.6 ( 2014)10.6 (;)-6.6 (9)10.5 (:)-6.6 (90.)4.2 ( )0.5 (A)1.9 (v)8.9 (ai)2.6 (l)2.6 (abl)2.5 (e at)-6.7 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 0 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24685141)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 488.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 486.6 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 465 Tm [(507.)-6.7 ( B)2 (ur)-6 (ni)2.7 (s)-2 (on)10.5 ( C)2.7 (M)15.7 (,)-6.6 ( Li)2.6 (m)-6 ( S)12.9 (.)-6.7 ( M)15.8 (ul)2.6 (t)-6.6 (i)2.6 (m)-6 (odal)2.6 ( appr)-6 (oac)-2 (h)10.5 ( t)-6.6 (o)10.6 ( anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ -0.004 Tw 0 -1.152 Td [(c)-2 (anc)-2 (er)-6 (.)4.3 ( O)-6.6 (nc)-2 (ol)2.6 (og)-11.2 (y)8.9 ( \()15.8 (W)-36.3 (i)2.6 (l)2.7 (l)2.6 (i)2.6 (s)-2 (t)4.2 (on )-10.6 (P)2 (ar)5 (k)]TJ 0.007 Tw 14.402 0 Td [(\))-6 ( 2012)10.5 (;)-6.6 (26:)-6.6 (378)]TJ 0 Tc 0 Tw 6.152 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(38)10.5 (4,)-6.6 ( 390)]TJ 0 Tc 0 Tw 3.87 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(378.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -25.098 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22655531)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 439.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 437.64 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 416.04 Tm [(508.)-6.7 ( )33.1 (W)-36.3 (a)10.5 (n)10.5 (g)-11.2 ( Y)12.9 (,)-6.7 ( )11.3 (T)-10.6 (s)-1.9 (an)10.5 (g R)2.6 (,)4.3 ( )11.2 (A)2 (s)-2 (a S)2 (,)-6.6 ( e)10.5 (t)4.3 ( al)2.6 (.)-6.6 ( C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.6 ( out)-6.6 (c)8.9 (om)-6 (e o)10.5 (f)-6.6 ( anapl)2.6 (as)8.8 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( t)4.2 (r)-5.9 (eat)-6.6 (ed)10.6 ( w)13.4 (i)2.7 (t)-6.7 (h r)4.9 (adi)2.6 (ot)-6.6 (her)-6 (ap)]TJ [(y)8.9 ( o)10.5 (f)-6.6 ( onc)-2 (e)]TJ 0 Tc 0 Tw (-)Tj 19.717 0 Td ( )Tj -0.002 Tc 0.007 Tw 0.283 0 Td [(and)10.5 ( t)-6.6 (w)13.5 (i)2.6 (c)-2 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 4.533 0 Td [(dai)2.6 (l)2.6 (y)8.9 ( f)-17.5 (r)-5.9 (ac)8.9 (t)-6.6 (i)2.6 (onat)-6.6 (i)2.7 (on )]TJ -24.533 -1.141 Td [(r)-6 (e)10.6 (g)-11.3 (i)2.7 (m)-6 (ens)-2 (.)4.3 ( C)2.6 (anc)-2 (e)10.5 (r)-6 ( )0.5 (2006)10.5 (;)4.3 (107:)-6.7 (1786)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 15.13 0 Td [(1792)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)-8.3 (e at)4.3 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -15.13 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (16967442)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 378 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 375.96 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 354.36 Tm [(509.)-6.7 ( N)2.7 (ac)-2 (hal)2.6 (on Y)12.9 (,)-6.7 ( S)12.9 (t)-6.6 (er)-5.9 (n)]TJ 0 Tc 0 Tw 10.304 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.326 0 Td [(S)2 (hav)8.8 (i)2.7 (t)-6.7 ( S)2 (,)-6.6 ( B)1.9 (ac)-2 (har)4.9 ( G)4.3 (,)-6.6 ( e)10.5 (t)4.2 ( al)2.6 (.)-6.6 ( A)12.8 (gg)-11.2 (r)-6 (e)10.5 (s)-2 (s)-2 (i)2.6 (v)]TJ 15.837 0 Td [(e P)2 (al)2.6 (l)2.6 (i)2.6 (at)-6.6 (i)2.6 (on )]TJ -26.467 -1.141 Td [(and S)1.9 (ur)-6 (v)8.9 (i)2.6 (v)8.9 (al)2.6 ( i)2.6 (n A)1.9 (napl)2.6 (as)-2 (t)-6.6 (i)-8.3 (c)-2 ( )11.3 (T)-10.6 (hy)8.9 (r)-5.9 (oi)2.6 (d C)2.6 (ar)-5.9 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( )11.2 (J)-2 (A)2 (M)4.9 (A)2 ( O)-6.7 (t)-6.6 (ol)2.6 (ar)-6 (y)8.9 (n)10.5 (g)-11.2 (ol)2.6 ( H)2.6 (ead )]TJ 0 -1.141 Td [(N)2.6 (ec)-2 (k)-2 ( S)1.9 (ur)4.9 (g 2015;)-6.6 (141)10.6 (:)-6.6 (112)10.5 (8)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 11.913 0 Td [(1132.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -11.913 -1.152 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (26512447)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 639.24 316.44 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 314.4 234.24 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 292.8 Tm [(510.)-6.7 ( D)2.7 (e C)13.5 (r)-6 (ev)8.9 (oi)2.6 (s)-2 (i)2.6 (er)-6 ( R)2.6 (,)-6.6 ( B)2 (a)]TJ 11.022 0 Td [(udi)2.6 (n E)1.9 (,)-6.6 ( B)2 (ac)-2 (hel)2.6 (ot)4.3 ( A)1.9 (,)4.3 ( et)4.3 ( al)2.7 (.)4.2 ( C)2.6 (om)-6 (bi)2.6 (ned )11.3 (t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-6 (en)10.5 (t)-6.6 ( )11.3 (o)10.5 (f)-6.6 ( )]TJ -11.022 -1.141 Td [(anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (n)10.6 (om)-6 (a w)13.5 (i)2.6 (t)-6.6 (h s)-2 (ur)4.9 (g)-11.2 (e)10.5 (r)-5.9 (y)8.8 (,)-6.6 ( c)-2 (he)10.5 (m)4.9 (ot)-6.7 (her)-5.9 (apy)8.9 (,)-6.6 ( and)10.5 ( )]TJ 0 -1.152 Td [(hy)8.8 (per)-5.9 (f)-6.6 (r)-6 (ac)-2 (t)-6.6 (i)2.6 (ona)10.5 (t)-6.6 (ed ac)8.9 (c)-2 (el)2.6 (er)-5.9 (at)-6.6 (ed)10.5 ( ex)8.8 (t)-6.6 (er)-6 (nal)2.6 ( r)-5.9 (adi)2.6 (o)10.5 (t)-6.6 (her)-5.9 (a)10.5 (py)8.9 (.)-6.6 ( I)-6.6 (nt)4.3 ( J)8.9 ( R)2.6 (adi)2.6 (at)-6.6 ( )11.3 (O)-6.6 (nc)-2 (ol)2.6 ( )]TJ 0 -1.141 Td [(B)2 (i)2.6 (ol)2.6 ( P)2 (hy)8.9 (s)-2 ( 2004;)-6.6 (60:)-6.6 (1137)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 10.859 0 Td [(1143.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -10.859 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (15519785)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 242.16 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 240.12 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 218.52 Tm [(511.)-6.7 ( K)2 (i)2.6 (m)4.9 ( J)-2 (H)2.6 (,)4.3 ( Leeper)4.9 ( R)2.6 (D)2.6 (.)4.3 ( )11.2 (T)-10.5 (r)-6 (ea)10.6 (t)-6.6 (m)-6 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( l)2.6 (oc)-2 (al)2.6 (l)2.6 (y)8.9 ( adv)-2 (anc)-2 (ed t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (a)10.5 (r)-6 (c)-1.9 (i)2.6 (nom)-6 (a)10.5 ( )]TJ 0 -1.141 Td [(w)2.6 (i)2.6 (t)-6.6 (h c)-2 (om)-5.9 (bi)2.6 (na)10.5 (t)-6.6 (i)2.6 (on dox)8.9 (or)-5.9 (ubi)2.6 (c)-2 (i)2.6 (n and r)-6 (adi)2.6 (at)-6.6 (i)2.6 (on )11.3 (t)-6.6 (her)-5.9 (a)10.5 (py)8.9 (.)-6.6 ( C)2.6 (anc)-2 (er)-6 ( 1987)10.5 (;)-6.6 (60:)-6.6 (237)10.5 (2)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 0 -1.141 Td [(2375.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.3 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.7 (nc)-2 (bi)2.6 (.)-6.7 (nl)2.6 (m)-5.9 (.)-6.7 (ni)2.6 (h.)-6.6 (g)-11.3 (ov)8.9 (/)-6.7 (pu)10.5 (bm)-6 (ed/)-6.6 (3664425)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 721.2 193.32 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 498.72 191.28 222.48 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 169.68 Tm [(512.)-6.7 ( M)15.8 (ohebat)-6.6 (i)2.6 ( A)1.9 (,)-6.5 ( D)2.6 (i)2.7 (l)2.6 (or)-5.9 (en)10.6 (z)8.8 (o )-10.5 (M)15.8 (,)-6.6 ( P)1.9 (al)2.6 (m)-6 (er)4.9 ( F,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( A)2 (n)10.5 (apl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (:)-6.6 ( a)10.5 ( 25)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 7.435 0 Td [(y)8.9 (ear)-6 ( s)-2 (i)2.6 (ng)-11.2 (l)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 5.152 0 Td [(i)2.6 (ns)-2 (t)-6.6 (i)13.4 (t)-6.6 (ut)-6.6 (i)2.6 (on ex)8.9 (per)-5.9 (i)2.6 (enc)-2 (e)10.5 (.)-6.6 ( A)1.9 (nn S)2 (u)10.5 (r)4.9 (g)-11.2 ( )11.3 (O)-6.6 (nc)-2 (ol)2.6 ( )]TJ 0.002 Tw -12.587 -1.141 Td [(2014;)-6.6 (21:)-6.6 (1665)]TJ 0 Tc 0 Tw 6.098 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1670.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.435 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (24554064)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 131.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 129.6 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 108 Tm [(513.)-6.7 ( D)2.7 (er)-5.9 (bel)13.4 ( O)4.3 (,)-6.6 ( Li)13.5 (m)-5.9 (em)4.9 ( S)2 (,)4.3 ( S)2 (eg)-11.3 (u)10.6 (r)-6 (a)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 14.804 0 Td [(Fe)10.5 (r)-5.9 (l)2.6 (ay)8.9 ( C)2.6 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( )11.3 (R)2.6 (es)-2 (ul)2.6 (t)-6.6 (s)-2 ( o)10.6 (f)-6.7 ( c)-2 (o)10.6 (m)-6 (bi)2.6 (ned )]TJ -14.804 -1.141 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( anapl)2.6 (as)8.9 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (t)4.2 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( \()-6 (A)12.8 (T)-10.5 (C)2.6 (\))4.9 (.)-6.6 ( )11.3 (B)-9 (M)15.8 (C)2.6 ( C)2.7 (anc)-2 (er)-6 ( )]TJ 0 -1.152 Td [(2011;)-6.6 (11:)-6.6 (469)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(ht)4.3 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.2 (g)-11.2 (ov)8.9 (/)-6.7 (pubm)-6 (ed/)4.2 (22044775)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 764.04 82.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 535.32 80.64 228.72 0.84 re f EMC endstream endobj 1129 0 obj 26091 endobj %% Contents for page 134 %% Original object ID: 269 0 1130 0 obj << /Length 1131 0 R >> stream Q q BT /Xi132 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1131 0 obj 246 endobj %% Original object ID: 12021 0 1132 0 obj [ 3157 0 R 3158 0 R 3159 0 R 3160 0 R 3161 0 R 3162 0 R 3163 0 R 3164 0 R 3165 0 R 3166 0 R 3167 0 R 3168 0 R 3169 0 R 3170 0 R 3171 0 R 3172 0 R 3173 0 R 3174 0 R ] endobj %% Contents for page 135 %% Original object ID: 270 0 1133 0 obj << /Length 1134 0 R >> stream q endstream endobj 1134 0 obj 2 endobj %% Contents for page 135 %% Original object ID: 12022 0 1135 0 obj << /Length 1136 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (72)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(514.)-6.7 ( )33.1 (W)-36.3 (al)2.7 (l)2.6 (i)2.6 (n )11.3 (G)-6.6 (,)4.2 ( Lundel)2.6 (l)2.6 ( G)4.3 (,)4.2 ( )11.3 (T)-10.5 (ennv)8.9 (al)2.7 (l)2.6 ( J)-2 (.)-6.7 ( A)2 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (g)-11.2 (i)13.5 (ant)-6.6 ( c)-1.9 (el)2.6 (l)2.6 ( )11.3 (t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( S)1.9 (c)-2 (and)10.6 ( J)-2 ( S)2 (u)10.5 (r)4.9 (g 2004;)-6.6 (93)10.5 (:)-6.6 (272)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 17.293 0 Td [(277)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -17.293 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (15658667)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 488.64 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 486.6 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 465 Tm [(515.)-6.7 ( S)12.9 (m)-6 (al)2.6 (l)2.6 (r)-6 (i)2.7 (dg)-11.2 (e)10.5 ( R)2.6 (C)2.6 (.)-6.6 ( A)2 (pp)10.6 (r)-6 (oac)-2 (h )11.2 (t)-6.6 (o )11.2 (t)-6.6 (he pa)10.5 (t)-6.6 (i)2.6 (ent)4.3 ( w)13.4 (i)2.7 (t)-6.7 (h anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.152 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( J)8.8 ( C)2.7 (l)2.5 (i)2.7 (n E)2 (ndoc)-2 (r)4.9 (i)2.7 (nol)2.6 ( )-10.5 (M)15.8 (et)-6.6 (ab 2012;)-6.6 (97)10.5 (:)-6.6 (2566)]TJ 0 Tc 0 Tw 22.043 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(2572.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -22.38 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22869844)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 439.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 437.64 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 416.04 Tm [(516.)-6.7 ( B)2 (ha)10.5 (t)-6.6 (i)2.6 (a A)2 (,)4.2 ( R)2.7 (ao A)1.9 (,)4.3 ( A)1.9 (n)10.6 (g K)2 (K)1.9 (,)-6.6 ( e)10.5 (t)-6.6 ( al)13.5 (.)-6.6 ( A)2 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)8.9 ( t)-6.6 (h)10.5 (y)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2.1 (er)-6 (:)4.3 ( C)2.6 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.7 ( )]TJ 0 -1.152 Td [(out)-6.6 (c)-2 (om)-6 (e)10.5 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h c)-1.9 (on)10.5 (f)-17.5 (o)10.6 (r)-6 (m)-5.9 (al)13.5 ( r)-6 (adi)2.6 (ot)-6.6 (he)10.6 (r)-6 (apy)8.9 (.)-6.6 ( H)2.6 (ead N)2.6 (ec)8.9 (k)-2 ( 2010;)-6.6 (32)10.6 (:)-6.7 (829)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 28.489 0 Td [(836)10.5 (.)-6.6 ( )]TJ 0.007 Tw -28.489 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (19885924)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 390.72 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 388.68 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 367.08 Tm [(517.)-6.7 ( S)2 (un)10.5 ( X)-8.9 (S)12.8 (,)-6.6 ( S)1.9 (un)10.5 ( S)2 (R)2.6 (,)-6.6 ( )11.2 (G)4.3 (uev)8.9 (ar)-5.9 (a N)2.6 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( C)2.6 (hem)-6 (o)10.5 (r)5 (adi)2.6 (at)-6.6 (i)2.6 (on i)2.6 (n anapl)2.6 (as)-2 (t)-6.7 (i)2.7 (c)-2 ( )]TJ 0 -1.152 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (as)-1.9 (.)4.2 ( C)2.6 (r)-5.9 (i)2.6 (t)4.2 ( )11.3 (R)2.6 (ev)8.8 ( O)-6.6 (nc)-2 (ol)2.7 ( H)2.6 (em)-5.9 (a)10.5 (t)-6.6 (ol)2.6 ( 201)10.5 (3;)-6.6 (86:)-6.6 (290)]TJ 0 Tc 0 Tw 25.196 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(301.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e )]TJ -0.006 Tc 0.006 Tw -25.533 -1.141 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (23218594)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 267.48 341.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 38.88 339.72 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 318.12 Tm [(518.)-6.7 ( )11.3 (G)-6.6 (r)-5.9 (e)10.5 (g)-11.2 (oi)2.6 (r)-5.9 (e)10.5 ( V)1.9 (,)4.3 ( M)15.8 (ac)-2 (k)-12.8 (i)2.6 (e )11.3 (T)-10.6 (R)2.6 (.)4.3 ( S)2 (t)-6.7 (a)10.6 (t)-6.6 (e o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (he )11.3 (ar)4.9 (t)-6.6 ( on)10.5 ( d)10.5 (os)-2 (e pr)-6 (es)8.8 (c)-1.9 (r)-6 (i)2.6 (pt)-6.6 (i)2.6 (on,)4.2 ( )]TJ 0 -1.141 Td [(r)-6 (epor)4.9 (t)-6.6 (i)2.6 (ng and )11.3 (r)-6 (ec)-1.9 (or)-6 (di)2.6 (n)10.5 (g i)2.6 (n I)-6.6 (n)10.6 (t)-6.7 (ens)-2 (i)2.7 (t)-6.7 (y)]TJ 0 Tc 0 Tw 15.348 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(M)15.8 (odul)2.7 (at)-6.6 (ed R)2.6 (adi)2.6 (at)-6.6 (i)2.6 (on T)-10.6 (he)10.5 (r)-6 (apy)8.9 ( \()4.9 (I)-6.6 (C)2.6 (R)2.6 (U)2.7 ( )]TJ -15.685 -1.152 Td [(r)-6 (epor)4.9 (t)-6.6 ( N)2.6 (o.)4.2 ( 83\))5 (.)-6.7 ( C)2.7 (anc)-2 (e)10.6 (r)-6 ( R)13.5 (adi)2.6 (ot)-6.6 (her)-6 ( 2011)10.5 (;)-6.6 (15:)-6.6 (555)]TJ 0 Tc 0 Tw 20.337 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(55)10.5 (9.)-6.6 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -20.674 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21802333)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 280.2 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 278.16 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 256.56 Tm [(519.)-6.7 ( P)2 (r)-6 (e)10.6 (s)-2 (c)-2 (r)-6 (i)2.6 (bi)2.6 (n)10.5 (g)-11.2 (,)4.3 ( R)2.6 (ec)-2 (or)-6 (d)10.5 (i)2.7 (ng)-11.2 (,)4.2 ( and R)2.6 (epo)10.6 (r)-6 (t)-6.6 (i)2.6 (n)10.5 (g)-11.2 ( P)2 (ho)10.5 (t)-6.6 (o)10.5 (n)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 22.88 0 Td [(B)2 (eam)4.9 ( I)-6.6 (n)10.5 (t)-6.6 (ens)-2 (i)2.6 (t)-6.6 (y)]TJ 0 Tc 0 Tw 6.587 0 Td (-)Tj -0.002 Tc 0.007 Tw -29.467 -1.152 Td [(M)15.8 (odu)-11.2 (l)2.6 (at)-6.6 (ed R)2.7 (adi)2.7 (at)-6.6 (i)2.6 (on )11.3 (T)-10.6 (h)10.5 (er)-6 (apy)8.9 ( \()-5.9 (I)-6.7 (M)15.8 (R)2.6 (T)-10.5 (\))4.9 (:)-6.6 ( C)2.6 (on)10.5 (t)-6.6 (ent)-6.6 (s)8.8 (.)-6.6 ( )11.3 (J)-2 ( I)-6.6 (C)2.6 (R)2.6 (U)2.6 ( 2010)10.5 (;)-6.6 (10:)-6.6 (N)2.6 (P)2 (.)4.2 ( )]TJ 0 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0 Tc 0 Tw (h)Tj -0.002 Tc 0.002 Tw 6.261 0 Td [(t)-6.6 (t)-6.6 (p)10.5 (:)-6.6 (/)4.3 (/)-6.6 (w)2.6 (w)2.6 (w)13.4 (.)-6.6 (nc)-2 (bi)2.7 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.2 (g)-11.2 (ov)8.8 (/)-6.6 (pub)10.6 (m)-6 (ed)10.5 (/)-6.6 (24173332)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 231.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 229.2 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 207.6 Tm [(520.)-6.7 ( S)2 (os)-2 (a)10.5 ( J)-2 (A)1.9 (,)4.3 ( B)2 (al)2.6 (k)-12.9 (i)2.7 (s)-2 (s)-2 (oo)10.5 (n J)-2 (,)4.2 ( )0.5 (Lu S)2 (P)12.8 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( )11.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (dec)-2 (t)-6.6 (om)-5.9 (y)8.9 ( )11.2 (f)-6.6 (ol)2.6 (l)2.6 (ow)13.5 (ed b)-11.2 (y)8.9 ( )]TJ 0 -1.152 Td [(f)-6.6 (os)-2 (br)-6 (e)10.6 (t)-6.6 (abul)2.6 (i)2.6 (n \()-6 (C)2.6 (A)2 (4P)2 (\))4.9 ( c)-2 (o)10.5 (m)-5.9 (bi)2.6 (nat)-6.7 (i)2.7 (on )11.2 (r)-5.9 (e)10.5 (g)-11.2 (i)2.6 (m)-6 (en appe)10.5 (ar)-6 (s)-2 ( )11.3 (t)-6.6 (o s)-2 (u)10.6 (gg)-11.2 (e)10.5 (s)-2 (t)4.3 ( )]TJ 0 -1.141 Td [(i)2.6 (m)-5.9 (pr)-6 (ov)8.9 (em)-5.9 (ent)4.2 ( i)2.7 (n pat)-6.6 (i)2.6 (en)10.5 (t)-6.6 ( s)8.8 (ur)-6 (v)8.9 (i)-8.3 (v)8.9 (al)2.6 ( i)2.6 (n anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.8 (r)5 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 (.)-6.6 ( S)2 (ur)5 (g)-11.3 (e)10.6 (r)-6 (y)8.9 ( )]TJ 0.002 Tw 0 -1.141 Td [(2012;)-6.6 (152:)-6.6 (1078)]TJ 0 Tc 0 Tw 6.652 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(1087.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -6.989 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (23158178)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 156.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 154.92 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 133.32 Tm [(521.)-6.7 ( S)2 (w)13.5 (aak)]TJ 0 Tc 0 Tw 5.217 0 Td (-)Tj -0.005 Tc 0.01 Tw 0.337 0 Td [(K)9.8 (r)-8.9 (a)7.5 (g)-14.2 (t)-9.7 (e)-3.3 (n)7.5 ( A)9.8 (T)-13.6 (,)1.3 ( d)-3.4 (e)-3.3 ( )33 (W)-39.3 (ilt)1.3 ( J)-5 (H,)1.3 ( S)-1.1 (c)-5 (h)7.5 (m)-8.9 (it)-9.6 (z)5.8 ( P)-1 (I)-9.7 (,)1.3 ( )11.3 (e)-3.4 (t)-9.6 ( a)-3.4 (l.)1.3 ( M)12.7 (u)-3.3 (lt)-9.6 (im)-9 (o)-3.3 (d)-3.4 (a)-3.3 (lit)-9.7 (y)5.9 ( )]TJ -0.002 Tc 0.007 Tw -5.554 -1.141 Td [(t)-6.6 (r)-6 (ea)10.5 (t)-6.6 (m)-5.9 (en)10.5 (t)-6.6 ( )11.3 (f)-6.6 (or)5 ( anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)8.9 ( t)4.3 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)]TJ -0.007 Tc (--)Tj -0.002 Tc 19.228 0 Td [(t)4.3 (r)-6 (eat)4.3 (m)4.9 (ent)-6.6 ( ou)10.6 (t)-6.6 (c)-2.1 (om)-5.9 (e)10.5 ( i)]TJ 8.804 0 Td [(n 75)10.5 ( )]TJ -28.033 -1.152 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 (.)4.3 ( R)2.6 (adi)2.6 (ot)-6.6 (her)5 ( )11.2 (O)-6.6 (nc)-2 (o)10.5 (l)2.6 ( 2009;)-6.6 (92:)-6.6 (100)]TJ 0 Tc 0 Tw 17.065 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(104.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)-8.3 (abl)2.7 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -17.402 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19328572)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 95.4 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 93.36 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 71.76 Tm [(522.)-6.7 ( S)2 (ubbi)2.6 (ah V)12.8 (,)-6.6 ( K)1.9 (r)-5.9 (ei)13.4 (t)-6.6 (m)-5.9 (a)10.5 (n R)2.6 (J)-2 (,)4.3 ( )22.1 (W)-36.2 (a)10.5 (i)2.6 (nber)4.9 (g ZA)1.9 (,)4.3 ( et)4.3 ( al)2.6 (.)-6.6 ( D)2.6 (abr)-5.9 (a)10.5 (f)-6.6 (eni)2.6 (b and)10.5 ( )]TJ 0 -1.152 Td [(T)-10.6 (r)-5.9 (a)10.5 (m)-6 (e)10.6 (t)-6.6 (i)2.6 (ni)2.6 (b Tr)-6 (ea)10.5 (t)-6.6 (m)-6 (en)10.5 (t)-6.6 ( i)2.6 (n )11.2 (P)]TJ 11.522 0 Td [(at)-6.7 (i)2.7 (ent)-6.6 (s)-2 ( )33 (W)-36.3 (i)13.5 (t)-6.6 (h Lo)10.5 (c)-2 (al)2.6 (l)2.6 (y)8.8 ( A)2 (dv)8.9 (anc)-2 (ed or)-6 ( M)15.8 (et)-6.6 (as)-2 (t)-6.6 (at)-6.7 (i)2.7 (c)8.8 ( )]TJ -0.004 Tc 0.009 Tw 23.033 41.207 Td [(BR)0.6 (AF)-1.7 ( V6)-2.4 (0)-2.3 (0)]TJ 0 Tc 0 Tw 5.261 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(M)15.8 (ut)-6.6 (ant)-6.6 ( A)2 (na)10.6 (pl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d C)2.6 (anc)-2 (er)5 (.)-6.7 ( J)8.9 ( C)2.6 (l)2.6 (i)2.6 (n O)-6.6 (nc)-2 (ol)2.6 ( 2018)10.6 (;)-6.6 (36:)-6.6 (7)]TJ 0 Tc 0 Tw 25.641 0 Td (-)Tj -0.002 Tc 0.007 Tw -31.239 -1.152 Td [(13.)-6.6 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.5 (t)-6.6 (t)-6.6 (ps)8.8 (:)4.3 (/)-6.6 (/)-6.6 (w)13.4 (w)2.7 (w)13.4 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.5 (nl)2.6 (m)-5.9 (.)-6.7 (ni)2.6 (h.)4.2 (g)-11.2 (ov)8.8 (/)-6.6 (pubm)-6 (ed/)-6.6 (29072975)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 720.6 501.24 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 486.48 499.2 234.121 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc -0.004 Tw 11.04 -0 0 11.04 405 477.6 Tm [(523.)-6.7 ( )-10.6 (H)2.7 (i)13.4 (g)-11.2 (as)-2 (hi)2.6 (y)8.9 (am)-6 (a T)-10.5 (,)4.2 ( )]TJ 0.007 Tw 9.424 0 Td [(I)4.3 (t)-6.7 (o )11.3 (Y)1.9 (,)-6.6 ( H)2.6 (i)2.6 (r)-5.9 (o)10.5 (k)-12.9 (aw)13.5 (a M)15.8 (,)-6.6 ( et)-6.7 ( al)2.6 (.)4.3 ( I)-6.6 (nd)10.5 (uc)-2 (t)-6.6 (i)2.6 (on c)-2 (he)10.6 (m)-6 (ot)-6.7 (he)10.5 (r)-5.9 (apy)8.8 ( )]TJ -9.424 -1.141 Td [(w)2.6 (i)2.6 (t)-6.6 (h w)13.4 (eek)-12.8 (l)2.6 (y)8.9 ( pac)-2 (l)2.6 (i)2.6 (t)-6.6 (ax)8.9 (el)2.7 ( ad)-11.2 (m)-6 (i)2.6 (ni)2.6 (s)-2 (t)-6.6 (r)-6 (a)10.6 (t)-6.6 (i)2.6 (on )11.3 (f)-17.5 (o)10.5 (r)-6 ( anapl)2.7 (as)8.9 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( )]TJ 0 -1.152 Td [(T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d 2010;)-6.6 (20)10.5 (:)-6.6 (7)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 8.37 0 Td [(14.)4.3 ( A)1.9 (v)8.9 (ai)-8.2 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -8.37 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (2002)]TJ (5538)Tj EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 439.68 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 437.64 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 416.04 Tm [(524.)-6.7 ( A)2 (i)2.6 (n K)1.9 (B)2 (.)4.2 ( A)2 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (t)4.3 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (:)-6.6 ( behav)8.9 (i)2.6 (or)-6 (,)4.3 ( bi)2.6 (ol)2.6 (og)-11.2 (y)8.9 (,)-6.6 ( and)10.5 ( )]TJ 0 -1.152 Td [(t)-6.6 (her)-6 (apeu)10.5 (t)-6.6 (i)2.6 (c)-2 ( appr)-6 (oa)10.5 (c)-2 (hes)-2 (.)4.3 ( )11.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d 1998;)-6.6 (8)10.5 (:)-6.6 (715)]TJ 0 Tc 0 Tw 19.554 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(726.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (ab)-11.2 (l)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -19.891 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (9737368)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 627.6 390.72 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 388.68 222.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 367.08 Tm [(525.)-6.7 ( A)2 (i)2.6 (n K)1.9 (B)2 (,)4.2 ( E)12.9 (g)-11.2 (or)-6 (i)2.7 (n)]TJ 0 Tc 0 Tw ( )Tj -0.002 Tc 0.007 Tw 8.989 0 Td [(M)15.8 (J)-2 (,)-6.6 ( )11.2 (D)2.7 (eS)2 (i)2.6 (m)-6 (one P)1.9 (A)2 (.)-6.6 ( )11.3 (Tr)-5.9 (eat)4.3 (m)-6 (en)10.5 (t)-6.6 ( o)10.5 (f)-6.6 ( anapl)2.6 (as)8.8 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.7 (d )]TJ -8.989 -1.152 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( w)13.5 (i)2.6 (t)-6.6 (h pac)-2 (l)2.6 (i)2.6 (t)-6.6 (ax)8.8 (el)-8.2 (:)-6.7 ( phas)-2 (e)10.5 ( 2 )11.2 (t)-6.6 (r)-5.9 (i)2.6 (al)2.6 ( us)-2 (i)2.6 (n)10.5 (g ni)2.6 (net)4.3 (y)]TJ 0 Tc 0 Tw 22.641 0 Td (-)Tj -0.005 Tc 0.005 Tw 0.337 0 Td [(s)-5 (ix)]TJ 0 Tc 0 Tw 1.207 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(hour)-6 ( i)2.6 (nf)-17.5 (us)-2 (i)2.7 (on)10.5 (.)-6.6 ( )]TJ -24.522 -1.141 Td [(C)2.6 (ol)2.6 (l)2.6 (abor)-5.9 (at)-6.6 (i)2.6 (v)8.9 (e A)1.9 (napl)2.6 (as)-2.1 (t)-6.6 (i)2.7 (c)-2.1 ( )0.5 (T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d C)2.6 (anc)-2 (er)4.9 ( H)2.7 (eal)2.6 (t)-6.6 (h )11.3 (I)-6.6 (n)10.5 (t)-6.6 (er)-5.9 (v)8.9 (ent)-6.6 (i)2.6 (on )11.2 (T)-10.5 (r)-6 (i)2.6 (al)2.6 (s)-2 ( )]TJ -0.004 Tw 0 -1.141 Td [(\()-6 (C)2.7 (A)1.9 (T)-10.6 (C)2.7 (H)2.6 (I)4.2 (T\))-5.9 ( G)-6.6 (r)-5.9 (oup)10.5 (.)4.3 ( T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )-10.7 (2000;)-6.6 (10:)-6.7 (587)]TJ 0 Tc 0 Tw 17.728 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(594.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -18.065 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (10958311)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 316.44 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 314.4 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 292.8 Tm [(526.)-6.7 ( U)2.7 (.)-6.7 (S)12.9 (.)-6.6 ( Food)10.5 ( and)10.5 ( D)2.6 (r)-5.9 (u)10.5 (g A)2 (dm)-6 (i)2.6 (ni)2.6 (s)-2 (t)-6.6 (r)-6 (a)10.5 (t)-6.6 (i)2.6 (on.)4.3 ( FD)2.6 (A)2 ( app)10.5 (r)-5.9 (ov)8.9 (es)-2 ( dabr)-6 (a)10.5 (f)-17.4 (eni)2.6 (b)10.5 ( pl)2.6 (us)-2 ( )]TJ 0 -1.141 Td [(t)-6.6 (r)-6 (a)10.6 (m)-6 (et)-6.7 (i)2.7 (ni)2.6 (b )11.3 (f)-6.7 (or)4.9 ( anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (er)4.9 ( w)13.5 (i)2.6 (t)-6.6 (h B)2 (R)2.6 (A)2 (F V)2 (600E)1.9 ( m)-5.9 (u)10.5 (t)-6.6 (a)10.5 (t)-6.6 (i)2.6 (on.)-6.6 ( 2018)10.5 (.)4.2 ( )]TJ 0 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC ET /Link <>BDC BT /CS0 cs 0 0.357 0.6 scn 0.002 Tw 11.04 -0 0 11.04 405 254.88 Tm [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (f)-17.5 (da)10.5 (.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (D)2.6 (r)-6 (u)10.5 (g)-11.2 (s)8.9 (/)-6.6 (I)-6.6 (n)10.5 (f)-6.6 (or)5 (m)-6 (at)-6.7 (i)2.7 (on)10.5 (O)-6.6 (nD)2.6 (r)-6 (u)10.6 (g)-11.3 (s)8.9 (/)4.3 (A)1.9 (ppr)-5.9 (ov)8.9 (edD)2.6 (r)-5.9 (ug)-11.2 (s)8.9 (/)-6.6 (uc)-2 (m)-5.9 (606)10.5 (7)]TJ ET 405 252.84 358.32 0.841 re f BT 11.04 -0 0 11.04 405 242.16 Tm [(08.)-6.6 (ht)4.3 (m)]TJ ET EMC /Span <>BDC BT /CS1 cs 0 scn 0.007 Tw 11.04 -0 0 11.04 438.72 242.16 Tm [(.)4.3 ( A)1.9 (c)-2 (c)-2 (es)-2 (s)-2 (ed)10.5 ( A)2 (u)10.5 (g)-11.2 (us)8.8 (t)-6.6 ( 24)10.5 (,)-6.6 ( 2018)10.6 (.)]TJ 0 Tc 0 Tw 12.674 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 240.12 33.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 218.52 Tm [(527.)-6.7 ( B)2 (r)-6 (o)10.6 (s)-2 (e M)15.8 (S)2 (,)-6.7 ( )0.5 (A)1.9 (l)2.6 (ber)-5.9 (t)4.2 ( C)13.5 (M)15.8 (,)-6.6 ( )22.1 (W)-36.2 (a)10.5 (g)-11.2 (ues)-2 (pa)10.6 (c)8.8 (k)-12.9 ( )0.5 (S)12.8 (G)-6.6 (,)4.2 ( et)4.2 ( a)10.6 (l)2.6 (.)-6.6 ( A)1.9 (c)-2 (t)-6.6 (i)2.6 (v)8.9 (i)2.6 (t)-6.6 (y)8.9 ( of)-6.6 ( l)2.6 (ar)-6 (o)10.5 (t)-6.6 (r)-5.9 (ec)8.9 (t)-6.6 (i)2.6 (ni)]TJ 0.002 Tw 31.728 0 Td (b )Tj 0.007 Tw -31.728 -1.141 Td [(i)2.6 (n pat)-6.6 (i)2.6 (ent)-6.6 (s)8.8 ( w)13.5 (i)2.6 (t)-6.6 (h adv)8.8 (anc)-2 (ed )11.2 (T)-10.6 (R)2.7 (K)1.9 ( )11.3 (f)-17.5 (us)-2 (i)2.6 (on)10.5 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (an)10.5 (c)-2 (er)-6 ( )11.3 ([)-6.6 (abs)-2 (t)4.2 (r)-5.9 (ac)8.9 (t)-6.6 (])4.2 (.)-6.6 ( 88)10.5 (t)-6.6 (h )]TJ 0 -1.141 Td [(A)2 (nnual)2.6 ( M)15.8 (eet)-6.6 (i)2.6 (ng)-11.2 ( o)10.5 (f)-6.6 ( t)-6.6 (he)10.5 ( A)1.9 (m)-5.9 (er)-5.9 (i)2.6 (c)-2 (an )11.3 (T)-10.6 (hy)8.8 (r)-5.9 (oi)2.6 (d A)1.9 (s)8.9 (s)-2 (oc)-2 (i)2.6 (at)-6.6 (i)2.6 (on 2018;)-6.6 (C)2.7 (l)2.5 (i)2.7 (ni)2.6 (c)-2 (al)2.6 ( O)4.2 (r)-5.9 (al)2.7 ( )]TJ 0 -1.152 Td [(P)2 (r)-6 (es)-2.1 (ent)-6.6 (a)10.5 (t)-6.6 (i)2.6 (on 10.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.7 (abl)-8.2 (e )0.5 (at)4.3 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 0 -1.141 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (l)2.6 (i)2.6 (eber)-6 (t)-6.6 (pub.)-6.6 (c)8.8 (om)-6 (/)-6.6 (doi)2.6 (/)-6.6 (pd)10.5 (f)-6.6 (/)-6.6 (10)10.6 (.)-6.6 (1089)10.6 (/)-6.7 (t)-6.6 (hy)8.9 (.)-6.7 (2)10.6 (018.)-6.6 (29065.)-6.6 (abs)8.9 (t)-6.6 (r)-6 (a)10.5 (c)-2 (t)-6.6 (s)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 742.56 168 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 165.96 337.56 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 144.36 Tm [(528.)-6.7 ( U)2.7 (.)-6.7 (S)12.9 (.)-6.6 ( Food)10.5 ( and)10.5 ( D)2.6 (r)-5.9 (u)10.5 (g A)2 (dm)-6 (i)2.6 (ni)2.6 (s)-2 (t)-6.6 (r)-6 (a)10.5 (t)-6.6 (i)2.6 (on.)4.3 ( FD)2.6 (A)2 ( app)10.5 (r)-5.9 (ov)8.9 (es)-2 ( l)2.6 (ar)-6 (ot)-6.6 (r)4.9 (ec)-2 (t)-6.6 (i)2.6 (ni)2.6 (b )11.2 (f)-6.6 (or)4.9 ( )]TJ 0 -1.152 Td [(s)-2 (ol)2.6 (i)2.6 (d t)-6.6 (um)-6 (o)10.5 (r)-5.9 (s)-2 ( w)13.4 (i)2.7 (t)-6.6 (h N)13.5 (T)-10.6 (R)2.6 (K)2 ( )11.3 (g)-11.3 (ene)10.6 ( )11.2 (f)-17.4 (us)-2 (i)2.6 (ons)8.9 (.)-6.6 ( 2018)10.6 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC ET /Link <>BDC BT /CS0 cs 0 0.357 0.6 scn 0.002 Tw 11.04 -0 0 11.04 405 119.04 Tm [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (f)-17.5 (da)10.5 (.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (D)2.6 (r)-6 (u)10.5 (g)-11.2 (s)8.9 (/)-6.6 (I)-6.6 (n)10.5 (f)-6.6 (or)5 (m)-6 (at)-6.7 (i)2.7 (on)10.5 (O)-6.6 (nD)2.6 (r)-6 (u)10.6 (g)-11.3 (s)8.9 (/)4.3 (A)1.9 (ppr)-5.9 (ov)8.9 (edD)2.6 (r)-5.9 (ug)-11.2 (s)8.9 (/)-6.6 (uc)-2 (m)-5.9 (626)10.5 (7)]TJ ET 405 117 358.32 0.84 re f BT 11.04 -0 0 11.04 405 106.32 Tm [(20.)-6.6 (ht)4.3 (m)]TJ ET EMC /Span <>BDC BT /CS1 cs 0 scn 0.007 Tw 11.04 -0 0 11.04 438.72 106.32 Tm [(.)4.3 ( A)1.9 (c)-2 (c)-2 (es)-2 (s)-2 (ed)10.5 ( N)2.7 (ov)8.9 (em)-5.9 (ber)4.9 ( 30,)4.3 ( 2018.)]TJ 0 Tc 0 Tw 14.174 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 104.28 33.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 82.68 Tm [(529.)-6.7 ( S)12.9 (m)-6 (al)2.6 (l)2.6 (r)-6 (i)2.7 (dg)-11.2 (e)10.5 ( R)2.6 (C)2.6 (,)-6.6 ( M)15.8 (ar)-5.9 (l)2.6 (o)-11.2 (w)13.5 ( LA)2 (,)-6.6 ( C)2.6 (opl)2.6 (and J)-2 (A)2 (.)4.3 ( A)1.9 (na)10.5 (pl)2.7 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-5.9 (:)4.2 ( )]TJ 0 -1.141 Td [(m)-6 (ol)2.6 (ec)-2 (ul)2.6 (ar)-6 ( pa)10.5 (t)-6.6 (ho)10.6 (g)-11.3 (enes)-2 (i)2.6 (s)-2 ( )11.3 (and em)-6 (e)10.6 (r)4.9 (g)-11.2 (i)2.6 (ng t)-6.6 (he)10.5 (r)-5.9 (api)2.6 (es)-2 (.)4.2 ( )11.3 (E)1.9 (ndoc)-2 (r)-5.9 ( )]TJ [(R)2.6 (el)2.6 (at)4.2 ( C)2.6 (anc)-2 (er)4.9 ( )]TJ 0.002 Tw 0 -1.141 Td [(2009;)-6.6 (16:)-6.6 (17)]TJ 0 Tc 0 Tw 4.989 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(44.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e)-11.2 ( at)4.3 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.326 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (18987168)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 44.76 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 42.72 228.72 0.84 re f EMC endstream endobj 1136 0 obj 27543 endobj %% Contents for page 135 %% Original object ID: 271 0 1137 0 obj << /Length 1138 0 R >> stream Q q BT /Xi133 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1138 0 obj 246 endobj %% Original object ID: 12041 0 1139 0 obj [ 3175 0 R 3176 0 R 3177 0 R 3178 0 R 3179 0 R 3180 0 R 3181 0 R 3182 0 R 3183 0 R 3184 0 R 3185 0 R 3186 0 R 3187 0 R 3188 0 R 3189 0 R 3190 0 R ] endobj %% Contents for page 136 %% Original object ID: 272 0 1140 0 obj << /Length 1141 0 R >> stream q endstream endobj 1141 0 obj 2 endobj %% Contents for page 136 %% Original object ID: 12042 0 1142 0 obj << /Length 1143 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (73)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(530.)-6.7 ( S)2 (av)8.8 (v)8.9 (i)2.6 (des)-2 ( P)2 (,)-6.6 ( N)2.6 (ag)-11.2 (ai)2.6 (a)10.5 (h G)4.3 (,)-6.6 ( Lav)8.9 (er)4.9 (t)-6.6 (u P)1.9 (,)4.3 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( P)2 (h)10.5 (as)-2 (e I)4.3 (I)-6.6 ( )11.2 (t)-6.6 (r)-5.9 (i)2.6 (al)2.6 ( o)10.6 (f)-6.7 ( )0.5 (s)-2.1 (o)10.6 (r)-6 (a)10.5 (f)-17.4 (eni)2.6 (b)10.5 ( i)2.6 (n )]TJ 0 -1.152 Td [(pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 ( w)13.5 (i)2.6 (t)-6.6 (h adv)8.9 (anc)-2 (ed a)10.6 (napl)2.6 (as)-2 (t)-6.6 (i)]TJ 14.402 0 Td [(c)-2 ( c)-2 (ar)4.9 (c)-2 (i)2.6 (nom)-6 (a o)10.5 (f)-6.6 ( )11.3 (t)-6.6 (h)10.5 (e t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d.)-6.6 ( )11.3 (T)-10.6 (hy)8.9 (r)-5.9 (oi)2.6 (d )]TJ 0.002 Tw -14.402 -1.141 Td [(2013;)-6.6 (23:)-6.6 (600)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(604.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.7 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.152 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (23113752)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 473.88 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 452.28 Tm [(531.)-6.7 ( P)2 (er)4.9 (r)-6 (i)2.6 ( F)11.2 (,)-6.6 ( Lo)10.6 (r)-6 (enz)8.9 (o G)4.3 (D)2.6 (,)-6.6 ( S)1.9 (c)-2 (ar)-6 (pa)10.5 (t)-6.6 (i)2.6 ( )11.3 (G)-6.6 (D)2.6 (,)4.3 ( B)1.9 (uoner)-5.9 (b)10.5 (a C)2.6 (.)-6.6 ( A)2 (napl)2.6 (as)8.9 (t)-6.6 (i)2.6 (c)-2 ( t)4.3 (hy)8.9 (r)-6 (oi)2.6 (d )]TJ 0 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (:)-6.6 ( A)12.8 ( c)]TJ 6.598 0 Td [(om)-6 (p)10.5 (r)-5.9 (ehen)10.6 (s)-2 (i)2.6 (v)8.8 (e r)-6 (ev)8.8 (i)2.7 (e)-11.3 (w)13.5 ( of)-17.5 ( c)-2 (u)10.5 (r)-5.9 (r)-6 (en)10.5 (t)-6.6 ( an)10.6 (d )11.3 (f)-17.5 (u)10.5 (t)-6.6 (ur)-6 (e)10.5 ( t)-6.6 (he)10.5 (r)-6 (apeut)-6.6 (i)2.6 (c)8.9 ( )]TJ -6.598 -1.152 Td [(opt)-6.6 (i)2.6 (ons)-2 (.)-6.6 ( )33 (W)-36.2 (o)10.5 (r)-6 (l)2.6 (d)10.5 ( J)-1.9 ( C)2.6 (l)2.6 (i)2.6 (n )11.3 (O)-6.6 (n)10.5 (c)-2 (ol)2.6 ( 2011;)-6.6 (2:)-6.6 (1)10.6 (50)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 17.62 0 Td [(157)10.5 (.)-6.6 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -17.62 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21611089)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 412.32 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 390.72 Tm [(532.)-6.7 ( D)2.7 (es)-2 (hpande)10.5 ( H)2.6 (A)2 (,)-6.6 ( )11.2 (G)-6.6 (e)10.5 (t)-6.6 (t)-6.6 (i)2.6 (n)10.6 (g)-11.3 (er)4.9 ( S)2 (N)2.6 (,)-6.6 ( S)1.9 (os)-2 (a)10.5 ( J)]TJ 18.902 0 Td [(A)12.8 (.)-6.6 ( N)2.6 (ov)8.8 (el)2.6 ( c)-2 (hem)-6 (o)10.6 (t)-6.6 (her)-6 (apy)8.9 ( opt)-6.6 (i)2.6 (ons)8.9 ( )]TJ -18.902 -1.152 Td [(f)-6.6 (or)5 ( adv)8.8 (anc)-2 (ed t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d t)-6.6 (u)10.5 (m)5 (or)-6 (s)-2 (:)4.3 ( s)8.9 (m)-6 (al)2.6 (l)2.6 ( m)-6 (ol)2.6 (ec)-2 (ul)2.6 (es)-2 ( o)10.5 (f)-6.6 (f)-6.6 (e)10.5 (r)-6 ( )11.3 (g)-11.2 (r)4.9 (eat)4.3 ( hope.)4.2 ( C)2.6 (ur)-5.9 (r)4.9 ( )11.2 (O)-6.6 (pi)2.6 (n )]TJ 0 -1.141 Td [(O)-6.6 (nc)-2 (ol)2.6 ( 2008)10.5 (;)-6.6 (20:)-6.6 (19)]TJ 0 Tc 0 Tw 7.87 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(24.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -8.207 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (18043252)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 350.76 228.721 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 329.16 Tm [(533.)-6.7 ( M)15.8 (ooney)8.9 ( C)]TJ 6.75 0 Td [(J)-2 (,)-6.6 ( N)2.6 (ag)-11.2 (ai)2.6 (a)10.5 (h G)4.2 (,)-6.6 ( Fu)10.6 ( P)2 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( A)1.9 ( )0.5 (phas)-2 (e)10.5 ( I)4.3 (I)-6.6 ( )11.3 (t)-6.7 (r)-5.9 (i)2.6 (al)2.7 ( o)10.5 (f)-6.6 ( )11.2 (f)-6.6 (os)-2 (br)-5.9 (e)10.5 (t)-6.6 (abul)2.6 (i)2.6 (n i)2.6 (n )]TJ -6.75 -1.152 Td [(adv)8.9 (anc)-2 (ed anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)4.9 (oi)2.7 (d c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 ( and )11.3 (c)-2 (or)4.9 (r)-6 (el)2.6 (at)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( bas)-2 (el)2.6 (i)2.6 (ne s)-2 (e)10.6 (r)-6 (um)]TJ 0 Tc 0 Tw 32.239 0 Td (-)Tj -0.002 Tc 0.007 Tw -32.239 -1.141 Td [(s)-2 (ol)2.6 (ubl)2.6 (e i)2.6 (nt)-6.6 (r)-6 (ac)-2 (el)2.7 (l)2.5 (ul)2.6 (ar)-6 ( adhe)10.5 (s)-2 (i)2.6 (on m)-5.9 (ol)2.6 (ec)-2 (ul)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 17.457 0 Td [(1 w)13.5 (i)2.6 (t)-6.6 (h ou)10.6 (t)4.2 (c)-2 (om)-6 (e.)4.2 ( )11.3 (T)-10.6 (hy)8.9 (r)-6 (oi)2.7 (d )]TJ 0.002 Tw -17.457 -1.152 Td [(2009;)-6.6 (19:)-6.6 (233)]TJ 0 Tc 0 Tw 5.543 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(240.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (a)-11.2 (bl)2.6 (e at)-6.6 (:)4.2 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -5.88 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (19265494)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 278.52 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 276.48 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 254.88 Tm [(534.)-6.7 ( H)2.7 (a H)13.5 (T,)-6.6 ( Lee)10.5 ( J)-2 (S)2 (,)4.2 ( U)2.6 (r)-5.9 (b)10.5 (a S)2 (,)-6.6 ( e)10.5 (t)4.3 ( al)2.6 (.)-6.6 ( A)12.9 ( phas)-2 (e )11.2 (I)-6.6 (I)4.3 ( s)8.9 (t)-6.7 (u)10.6 (dy)8.9 ( of)-6.6 ( i)2.6 (m)-5.9 (a)10.5 (t)-6.6 (i)2.6 (ni)2.6 (b i)2.6 (n pat)-6.6 (i)2.6 (ent)4.3 (s)-2 ( )]TJ 0 -1.152 Td [(w)2.6 (i)2.6 (t)-6.6 (h adv)8.8 (anc)-1.9 (ed anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-5.9 (.)4.2 ( )11.3 (T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d 2010;)-6.6 (20)10.5 (:)-6.6 (975)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 27.717 0 Td [(980)10.5 (.)-6.6 ( )]TJ 0.007 Tw -27.717 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (20718683)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 229.56 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 227.52 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 205.92 Tm [(535.)-6.7 ( B)2 (i)2.6 (bl)2.6 (e K)2 (C)2.6 (,)-6.6 ( S)1.9 (u)10.6 (m)-6 (an)10.5 ( V)1.9 (J)-2 (,)-6.6 ( M)15.8 (enef)-17.5 (ee)10.5 ( M)15.8 (E)1.9 (,)-6.6 ( et)4.3 ( al)2.6 (.)-6.6 ( A)12.8 ( )11.3 (m)-6 (ul)2.7 (t)-6.7 (i)2.7 (i)2.6 (ns)-2 (t)-6.6 (i)2.6 (t)-6.6 (ut)-6.6 (i)2.6 (onal)2.7 ( pha)10.6 (s)-2 (e 2)10.5 ( )]TJ 0 -1.141 Td [(t)-6.6 (r)-6 (i)2.6 (al)2.6 ( o)10.5 (f)-6.6 ( paz)8.9 (opani)2.6 (b m)-6 (ono)10.5 (t)4.3 (her)-6 (apy)8.8 ( i)2.6 (n adv)8.9 (anc)-2 (ed anapl)2.6 (as)-2 (t)-6.7 (i)2.7 (c)-2 ( t)-6.7 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (e)10.6 (r)-6 (.)4.3 ( J)8.8 ( )]TJ 0 -1.152 Td [(C)2.6 (l)2.6 (i)2.6 (n E)1.9 (ndoc)-2 (r)-6 (i)2.7 (nol)2.6 ( M)15.8 (et)-6.6 (ab 2012)]TJ 0.002 Tw [(;)-6.6 (97:)-6.6 (3179)]TJ 0 Tc 0 Tw 16.12 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(3184.)4.3 ( A)1.9 (v)8.9 (ai)2.7 (l)-8.3 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -16.457 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (22774206)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 168 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 165.96 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 144.36 Tm [(536.)-6.7 ( A)2 (n)10.5 (t)-6.6 (onel)2.6 (l)2.6 (i)2.6 ( A)2 (,)-6.6 ( Fal)2.6 (l)2.6 (ahi)2.6 ( P)2 (,)-6.6 ( U)2.6 (l)2.6 (i)2.6 (s)-2 (s)-2 (e S)1.9 (,)4.3 ( et)4.3 ( al)2.6 (.)4.2 ( N)2.6 (ew)13.5 ( t)-6.7 (ar)-5.9 (get)-6.7 (ed)10.5 ( t)-6.6 (he)10.5 (r)-6 (api)2.6 (es)-2 ( )11.3 (f)-6.6 (or)4.9 ( )]TJ 0 -1.152 Td [(anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)4.9 (.)-6.6 ( A)1.9 (nt)-6.6 (i)2.6 (c)-2 (anc)-2 (e)10.5 (r)-5.9 ( A)12.8 (g)-11.2 (en)10.6 (t)-6.7 (s)8.9 ( M)15.8 (ed)-11.2 ( )]TJ [(C)2.6 (hem)5 ( 2012;)-6.6 (12)10.5 (:)-6.6 (87)]TJ 0 Tc 0 Tw (-)Tj -0.013 Tc 0.013 Tw 30.424 0 Td [(9)-11.3 (3.)-17.6 ( )]TJ -0.002 Tc 0.007 Tw -30.424 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.5 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (22043992)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 315.24 119.04 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 86.64 117 228.6 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 95.4 Tm [(537.)-6.7 ( S)2 (os)-2 (a)10.5 ( J)-2 (A)1.9 (,)4.3 ( E)2 (l)2.6 (i)2.6 (s)-2 (ei)2.6 ( R)2.6 (,)-6.6 ( J)8.9 (ar)-6 (z)8.9 (ab B)1.9 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( )0.5 (R)2.6 (andom)-6 (i)2.6 (z)8.9 (ed s)-2 (a)10.5 (f)-17.5 (e)10.6 (t)-6.6 (y)8.8 ( and e)10.5 (f)-6.6 (f)-6.6 (i)2.6 (c)-2 (ac)-2 (y)8.8 ( )]TJ 0 -1.152 Td [(s)-2 (t)-6.6 (udy)8.9 ( o)10.5 (f)-17.5 ( )11.3 (f)-6.6 (os)-2 (b)10.6 (r)-6 (et)-6.6 (abul)2.6 (i)2.6 (n w)13.5 (i)2.6 (t)-6.7 (h pac)-2 (l)2.6 (i)2.6 (t)-6.6 (ax)8.8 (el)2.6 (/)-6.6 (c)-2 (ar)-6 (bopl)2.6 (at)-6.6 (i)2.6 (n a)10.5 (g)-11.2 (ai)2.6 (ns)-2 (t)4.3 ( anapl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)8.9 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )]TJ -0.004 Tw 0 -1.141 Td [(c)-2 (ar)-6 (c)-2 (i)2.6 (nom)-5.9 (a)10.5 (.)-6.6 ( T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (2014)10.5 (;)-6.6 (24:)-6.6 (232)]TJ 0 Tc 0 Tw 14.293 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(240.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -14.63 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (23721245)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 252.24 57.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 23.52 55.44 228.721 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 513.96 Tm [(538.)-6.7 ( Foo)10.5 (t)-6.6 (e R)2.6 (L)10.5 (,)-6.6 ( M)15.8 (ol)2.6 (i)2.7 (na J)-2 (R)2.7 (,)-6.7 ( )0.5 (K)1.9 (as)-2 (per)-6 (baue)10.5 (r)-6 ( )11.3 (J)-2 (L,)4.2 ( et)4.2 ( al)2.6 (.)4.3 ( E)1.9 (nhanc)-2 (ed s)-2 (u)10.5 (r)-5.9 (v)8.9 (i)2.6 (v)8.9 (a)-11.3 (l)2.6 ( i)2.6 (n )]TJ 0 -1.152 Td [(l)2.6 (oc)-2 (or)-5.9 (eg)-11.2 (i)2.6 (onal)2.6 (l)2.6 (y)8.9 ( c)-2 (on)10.5 (f)-17.5 (i)2.7 (ned a)10.6 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (r)-6 (c)-2 (i)2.6 (no)10.5 (m)-6 (a:)4.2 ( )0.5 (a s)-2 (i)2.6 (n)10.5 (g)-11.2 (l)2.6 (e)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 27.37 0 Td [(i)2.6 (ns)8.8 (t)-6.6 (i)2.6 (t)-6.6 (ut)-6.6 (i)2.6 (on )]TJ 0.007 Tw -27.37 -1.141 Td [(ex)8.8 (per)-5.9 (i)2.6 (enc)-2 (e us)-2 (i)2.6 (ng)-11.3 ( a)10.6 (ggr)-6 (es)8.8 (s)-2 (i)2.6 (v)8.9 (e m)-6 (ul)2.6 (t)-6.6 (i)2.6 (m)-6 (odal)2.6 ( t)-6.6 (he)10.5 (r)-5.9 (apy)8.9 (.)-6.6 ( )11.2 (T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d 2011;)-6.6 (2)]TJ -0.013 Tc 0.013 Tw [(1:)-17.6 (2)-11.3 (5)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw 30.804 0 Td [(30.)4.3 ( )]TJ 0.007 Tw -30.804 -1.152 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (21162687)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 475.92 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 473.88 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 452.28 Tm [(539.)-6.7 ( N)2.7 (a)10.5 (g)-11.2 (ai)2.6 (ah )11.3 (G)-6.6 (,)4.2 ( H)2.7 (os)-2 (s)-2 (ai)13.4 (n A)1.9 (,)-6.6 ( )0.5 (M)15.7 (ooney)8.9 ( C)2.6 (J)-2 (,)-6.6 ( et)4.2 ( al)2.6 (.)4.2 ( A)12.9 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-6 (:)4.3 ( )11.3 (a )]TJ 0 -1.141 Td [(r)-6 (ev)8.9 (i)2.6 (e)-11.2 (w)13.5 ( of)-6.6 ( epi)2.6 (dem)-5.9 (i)2.6 (ol)2.6 (og)-11.2 (y)8.8 (,)4.3 ( )11.3 (pat)-6.7 (ho)10.5 (g)-11.2 (enes)-2 (i)2.6 (s)-2 (,)4.2 ( )0.5 (and )11.3 (t)-6.6 (r)-6 (ea)10.5 (t)4.2 (m)-5.9 (ent)4.2 (.)-6.5 ( J)]TJ 0 Tc 0 Tw 24.37 0 Td ( )Tj -0.002 Tc 0.002 Tw 0.272 0 Td [(O)-6.6 (nc)-2 (ol)2.6 ( )]TJ 0.007 Tw -24.641 -1.152 Td [(2011;)-6.6 (2011:)-6.6 (542358)10.5 (.)-6.6 ( A)1.9 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)4.3 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw 0 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (21772843)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 414.36 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 412.32 228.72 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 390.72 Tm [(540.)-6.7 ( S)2 (i)2.6 (i)2.6 (r)-5.9 (onen P)12.8 (,)-6.6 ( H)2.6 (a)10.5 (g)-11.2 (s)8.9 (t)-6.6 (r)-6 (o)10.5 (m)-5.9 ( J)8.9 (,)-6.7 ( M)15.8 (aenpaa H)2.6 (O)4.3 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.2 ( )11.3 (A)2 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( and poo)10.6 (r)-6 (l)2.6 (y)8.9 ( )]TJ 0 -1.152 Td [(di)2.6 (f)-6.6 (f)-6.7 (er)-6 (en)10.5 (t)-6.6 (i)2.6 (at)-6.6 (ed )11.2 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d c)-2 (a)10.6 (r)4.9 (c)-2 (i)2.6 (nom)-6 (a:)4.2 ( t)-6.6 (he)10.5 (r)-6 (apeu)]TJ [(t)-6.7 (i)2.7 (c)-2 ( )11.2 (s)-2 (t)4.3 (r)-6 (at)4.2 (eg)-11.2 (i)2.6 (es)-2 ( and)10.6 ( t)4.2 (r)-5.9 (ea)10.6 (t)-6.7 (m)-5.9 (en)10.6 (t)-6.6 ( )]TJ 0 -1.141 Td [(out)-6.6 (c)-2 (om)-6 (e)10.5 ( o)10.5 (f)-6.6 ( 52)10.5 ( c)-2 (ons)-2 (ec)-2 (u)10.5 (t)-6.6 (i)2.6 (v)8.9 (e pat)-6.6 (i)2.6 (ent)-6.6 (s)-2 (.)4.3 ( O)-6.6 (n)10.5 (c)-2 (ol)2.7 (og)-11.2 (y)8.9 ( 20)10.5 (10;)-6.6 (79:)-6.6 (400)]TJ 0 Tc 0 Tw 26.207 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(408.)4.2 ( A)2 (v)8.9 (ai)2.6 (l)2.6 (abl)2.6 (e)-11.2 ( )]TJ -0.006 Tc 0.006 Tw -26.543 -1.141 Td [(a)-4.3 (t)-10.7 (: )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn -0.002 Tc 0.002 Tw 1.391 0 Td [(ht)4.2 (t)-6.6 (p:)4.2 (/)-6.6 (/)-6.6 (w)13.5 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-5.9 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.3 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (21455012)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 648.96 352.8 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 420.36 350.76 228.6 0.841 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 329.16 Tm [(541.)-6.7 ( B)2 (r)-6 (i)13.5 (g)-11.2 (na)10.5 (r)-6 (del)2.7 (l)2.6 (o E)2 (,)-6.6 ( )11.2 (G)-6.6 (al)2.6 (l)2.6 (o M)15.8 (,)-6.6 ( B)2 (al)2.6 (di)2.6 ( I)-6.6 (,)4.2 ( )0.5 (et)4.3 ( al)2.6 (.)-6.6 ( )]TJ -0.004 Tw [(A)2 (napl)2.6 (a)10.5 (s)-1.9 (t)-6.7 (i)2.7 (c)-2 ( t)-6.6 (hy)8.8 (r)-5.9 (oi)2.6 (d )-10.6 (c)-2 (ar)-6 (c)-2 (i)2.6 (no)10.5 (m)-6 (a:)4.2 ( )]TJ 0.007 Tw 0 -1.152 Td [(c)-2 (l)2.6 (i)2.6 (ni)2.6 (c)-2 (al)2.7 ( out)-6.6 (c)-2 (om)-6 (e o)10.5 (f)-6.6 ( 30)10.6 ( c)-2 (o)10.5 (ns)-2.1 (ec)-2 (ut)-6.7 (i)2.7 (v)8.8 (e pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( r)-6 (e)10.5 (f)-6.6 (er)4.9 (r)4.9 (ed t)-6.6 (o)10.5 ( a s)-2 (i)2.6 (n)10.5 (g)-11.2 (l)2.6 (e i)2.7 (ns)8.9 (t)-6.6 (i)2.6 (t)-6.6 (ut)-6.6 (i)2.6 (on )]TJ 0 -1.141 Td [(i)2.6 (n t)-6.6 (he pas)8.8 (t)4.3 ( 5 y)8.9 (ear)-6 (s)-1.9 (.)4.2 ( E)2 (ur)4.9 ( J)8.9 ( E)2 (ndoc)-2 (r)-5.9 (i)2.6 (nol)2.6 ( 2007;)-6.6 (1)10.5 (56:)-6.6 (42)10.5 (5)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 22.717 0 Td [(430.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.005 Tc -0.005 Tw -22.717 -1.152 Td [(h)6.7 (ttp)17.6 (:/)11.2 (/w)9.7 (w)9.6 (w)20.4 (.n)6.7 (c)5 (b)6.7 (i)9.6 (.n)6.6 (l)9.6 (m)]TJ -0.002 Tc 0.002 Tw 8.641 0 Td [(.)-6.6 (ni)2.7 (h.)4.3 (gov)8.8 (/)-6.6 (pubm)-6 (ed/)-6.6 (17389456)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 291.12 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 289.08 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 267.48 Tm [(542.)-6.7 ( Y)2 (au)10.5 ( )11.3 (T)-10.6 (,)4.2 ( Lo C)2.7 (Y)1.9 (,)4.3 ( E)1.9 (ps)-2 (t)4.2 (ei)2.6 (n R)2.7 (J)-2 (,)-6.6 ( e)10.5 (t)-6.6 ( al)2.6 (.)4.3 ( )11.3 (T)-10.6 (r)-6 (e)10.6 (at)4.3 (m)-6 (ent)4.3 ( )11.3 (out)-6.7 (c)-2 (om)-5.9 (e)10.5 (s)-2 ( i)2.6 (n anapl)2.7 (as)8.9 (t)-6.6 (i)2.6 (c)-2 ( )]TJ 0 -1.141 Td [(t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (ar)-5.9 (c)-2 (i)2.6 (nom)4.9 (a:)4.3 ( s)-2 (ur)-6 (v)8.9 (i)2.6 (v)-2 (al)2.7 ( i)2.7 (m)-6 (pr)-6 (ov)8.8 (em)-6 (ent)4.3 ( i)2.6 (n y)8.8 (oung pat)-6.6 (i)2.6 (ent)-6.6 (s)8.9 ( w)13.5 (i)2.6 (t)-6.6 (h l)2.6 (oc)-2 (al)2.7 (i)2.6 (z)8.9 (ed )]TJ 0 -1.152 Td [(di)2.6 (s)-2 (eas)-2 (e t)4.3 (r)-6 (eat)-6.6 (ed)10.5 ( by)8.9 ( c)-2 (om)-6 (bi)13.5 (nat)-6.7 (i)2.7 (on o)10.5 (f)-6.6 ( s)-2 (ur)4.9 (ger)-5.9 (y)8.9 ( and )11.3 (r)-6 (ad)10.5 (i)2.6 (ot)-6.6 (her)-6 (apy)8.9 (.)-6.6 ( A)1.9 (nn S)2 (u)10.5 (r)4.9 (g)-11.2 ( )]TJ 0 -1.141 Td [(O)-6.6 (nc)-2 (ol)2.6 ( 2008)10.5 (;)-6.6 (15:)-6.6 (250)]TJ 0 Tc 0 Tw (0)Tj 8.978 0 Td (-)Tj -0.002 Tc 0.007 Tw 0.337 0 Td [(250)10.5 (5.)-6.6 ( A)1.9 (v)8.9 (ai)2.7 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -9.315 -1.141 Td [(ht)-6.7 (t)-6.6 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (gov)8.9 (/)-6.6 (pubm)-5.9 (ed/)-6.6 (18581185)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 633.72 216.96 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 214.92 228.72 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 193.32 Tm [(543.)-6.7 ( P)2 (ar)4.9 (k)-2 ( J)30.6 (W)-36.3 (,)4.3 ( )11.3 (C)2.6 (hoi)2.6 ( S)1.9 (H)2.6 (,)4.3 ( )11.3 (Y)1.9 (oon H)2.6 (I)-6.6 (,)4.3 ( et)4.3 ( al)2.6 (.)4.3 ( )11.2 (T)-10.5 (r)-6 (ea)10.5 (t)-6.6 (m)-6 (en)10.5 (t)-6.6 ( ou)10.6 (t)-6.6 (c)-2 (om)-5.9 (e)10.5 (s)-2 ( o)10.5 (f)-6.6 ( )]TJ 0 -1.152 Td [(r)-6 (adi)2.7 (ot)-6.6 (her)-5.9 (apy)8.8 ( )11.3 (f)-17.5 (o)10.6 (r)-6 ( an)10.6 (apl)2.6 (as)-2 (t)4.3 (i)2.6 (c)-2 ( t)-6.6 (hy)8.9 (r)-5.9 (oi)2.6 (d c)-2 (anc)-2 (e)10.5 (r)-5.9 (.)4.2 ( R)2.6 (adi)2.6 (at)-6.6 ( )11.3 (O)-6.7 (nc)-2 (ol)2.7 ( J)8.8 ( 2018;)-6.6 (36)10.5 (:)-6.6 (1)]TJ 0.002 Tw (03)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 0 -1.141 Td [(113.)-6.7 ( A)2 (v)8.9 (ai)2.6 (l)2.7 (abl)2.6 (e at)-6.6 (:)-6.7 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.6 (ps)8.9 (:)4.3 (/)-6.7 (/)4.3 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)-6.6 (g)-11.2 (ov)8.9 (/)-6.6 (pu)10.5 (bm)-5.9 (ed/)-6.6 (29983030)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 726.72 168 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 492.6 165.96 234.121 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 144.36 Tm [(544.)-6.7 ( R)2.7 (ao S)1.9 (N)13.5 (,)-6.6 ( Za)10.5 (f)-6.6 (er)-6 (eo)10.5 ( M)15.8 (,)-6.6 ( D)2.7 (adu R)2.6 (,)4.3 ( et)4.3 ( al)2.7 (.)4.2 ( P)2 (at)-6.6 (t)-6.6 (e)10.5 (r)-5.9 (ns)8.9 ( )11.3 (o)10.5 (f)-17.5 ( )11.3 (Tr)-6 (eat)4.3 (m)-6 (ent)4.3 ( Fai)2.6 (l)2.6 (ur)-5.9 (e i)2.6 (n )]TJ -0.004 Tw 0 -1.152 Td [(A)2 (napl)2.6 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( T)-10.5 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (C)2.6 (ar)-5.9 (c)-2 (i)2.6 (nom)-6 (a.)4.2 ( T)-10.6 (hy)8.9 (r)-6 (oi)2.6 (d )-10.6 (2017;)-6.6 (27)10.5 (:)-6.6 (6)10.5 (72)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 23.326 0 Td [(681.)4.2 ( A)2 (v)8.8 (ai)2.6 (l)2.6 (abl)2.6 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw -23.326 -1.141 Td [(ht)-6.7 (t)-6.6 (ps)8.9 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-1.9 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pubm)-5.9 (ed)10.5 (/)-6.6 (28068873)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 639.24 119.04 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 405 117 234.24 0.84 re f EMC BT /P <>BDC /CS1 cs 0 scn -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 405 95.4 Tm [(545.)-6.7 ( H)2.7 (er)]TJ 3.837 0 Td [(on)10.5 ( D)2.6 (E)1.9 (,)4.3 ( K)2 (ar)-5.9 (i)2.6 (m)-6 (po)10.5 (ur)-5.9 ( S)1.9 (,)4.3 ( )11.3 (G)-6.6 (r)-6 (i)13.5 (g)-11.2 (s)-2 (by)8.9 ( P)23.7 (W)-36.3 (.)4.3 ( )11.3 (A)1.9 (napl)13.4 (as)-2 (t)-6.6 (i)2.6 (c)-2 ( )11.3 (t)-6.6 (hy)8.9 (r)-6 (oi)2.6 (d )0.5 (c)-2 (ar)-5.9 (c)-2.1 (i)2.6 (no)10.5 (m)-5.9 (a:)4.3 ( )]TJ -3.837 -1.152 Td [(c)-2 (om)-6 (par)-5.9 (i)2.6 (s)-2 (on)10.5 ( o)10.6 (f)-6.6 ( c)-2 (onv)8.8 (ent)-6.6 (i)2.6 (onal)2.6 ( r)-6 (adi)2.7 (ot)-6.6 (her)-5.9 (apy)8.8 ( and)10.6 ( hy)8.9 (per)4.9 (f)-17.5 (r)4.9 (ac)-2 (t)-6.6 (i)2.6 (onat)-6.6 (i)2.6 (on)10.5 ( )]TJ 0 -1.141 Td [(c)-2 (hem)-5.9 (or)-5.9 (adi)2.6 (o)10.5 (t)-6.6 (her)-6 (apy)8.9 ( i)2.6 (n t)-6.6 (w)13.4 (o )11.3 (g)-11.3 (r)-5.9 (oups)8.9 (.)-6.6 ( A)12.8 (m)-5.9 ( J)8.8 ( C)2.6 (l)2.7 (i)2.6 (n O)-6.6 (nc)8.8 (ol)2.6 ( 2002;)-6.6 (25:)-6.6 (442)]TJ 0 Tc 0 Tw 28.261 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.337 0 Td [(446.)4.2 ( )]TJ 0.007 Tw -28.598 -1.141 Td [(A)2 (v)8.8 (ai)-8.3 (l)2.6 (abl)2.7 (e at)-6.6 (:)-6.6 ( )]TJ EMC /Link <>BDC /CS0 cs 0 0.357 0.6 scn 0.002 Tw [(h)10.6 (t)-6.6 (t)-6.7 (p)10.6 (:)-6.6 (/)4.2 (/)-6.6 (w)2.6 (w)2.6 (w)13.5 (.)-6.6 (nc)-2 (bi)2.6 (.)-6.6 (nl)2.6 (m)-6 (.)-6.6 (ni)2.6 (h.)4.3 (g)-11.2 (ov)8.9 (/)-6.6 (pub)10.5 (m)-5.9 (ed)10.5 (/)-6.6 (12393980)]TJ EMC ET /Span <>BDC BT /CS1 cs 0 scn 0 Tc 0 Tw 11.04 -0 0 11.04 696.72 57.48 Tm (.)Tj 0.272 0 Td ( )Tj ET /CS0 cs 0 0.357 0.6 scn 468.12 55.44 228.6 0.84 re f EMC endstream endobj 1143 0 obj 27433 endobj %% Contents for page 136 %% Original object ID: 273 0 1144 0 obj << /Length 1145 0 R >> stream Q q BT /Xi134 7 Tf 0 0 0 rg 1 0 0 1 15 602 Tm (Printed by Alexander Newman on 1/27/2021 2:08:24 PM. For personal use only. Not approved for distribution. Copyright © 2021 National Comprehensive Cancer Network, Inc., All Rights Reserved.)Tj ET Q endstream endobj 1145 0 obj 246 endobj %% Original object ID: 12059 0 1146 0 obj [ 3191 0 R 3192 0 R 3193 0 R ] endobj %% Contents for page 137 %% Original object ID: 274 0 1147 0 obj << /Length 1148 0 R >> stream q endstream endobj 1148 0 obj 2 endobj %% Contents for page 137 %% Original object ID: 12060 0 1149 0 obj << /Length 1150 0 R >> stream /Artifact <>BDC q 220.9 108.6 349.9 349.899 re W n q /GS0 gs 349.8999696 0 0 349.8999696 220.8999634 108.6000609 cm /Im0 Do Q EMC Q BT /Artifact <>BDC /CS1 cs 0 scn /TT0 1 Tf 11.04 -0 0 11.04 182.52 544.2 Tm ( )Tj 0.283 0 Td ( )Tj 17.435 0 Td ( )Tj EMC /Artifact <>BDC 6 -0 0 6 23.52 18.12 Tm (V)Tj 0.004 Tc -0.004 Tw 0.66 0 Td [(er)-3 (s)4 (i)-14 (on)20 ( )]TJ 0 Tc 0 Tw 3.02 0 Td (2)Tj 0.004 Tc -0.004 Tw 0.56 0 Td [(.)2 (202)20 (0)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.001 Tw 2.78 0 Td [-1 (0)]TJ 0.004 Tc -0.004 Tw 2.12 0 Td (20)Tj 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 1.4 0 Td [(N)6 (at)22 (i)-14 (on)20 (al)6 ( C)6 (om)37 (pr)-3 (ehens)4 (i)6 (v)3.9 (e)]TJ 0 Tc 0 Tw ( )Tj 0.004 Tc -0.002 Tw 11.22 0 Td [(C)6 (anc)4 (er)-3 ( N)6 (et)2 (w)26 (or)-3 (k)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 197.16 20.64 Tm Tj 6 -0 0 6 200.04 18.12 Tm ( )Tj -0.002 Tc 0.002 Tw 0.28 0 Td [(\()-9 (NCCN)]TJ 0 Tc 0 Tw 3.96 -0 0 3.96 221.04 20.64 Tm Tj 0.004 Tc -0.002 Tw 6 -0 0 6 223.92 18.12 Tm [(\))-3 (,)2 ( A)11 (l)6 (l)-14 ( r)17 (i)-14 (gh)20 (t)2 (s)4 ( r)-3 (es)4 (e)20 (r)17 (v)4 (ed.)2 ( N)6.1 (C)6 (C)6 (N)5.9 ( G)2 (ui)6 (de)20 (l)6 (i)-14 (nes)4 1 ( a)20 (nd t)2 (h)20 (i)-14 (s)4 ( )20 (i)6 (l)6 (l)-14 (us)4 (t)22 (r)-3 (at)22 (i)-14 (on m)37 (ay)4 ( not)2 ( be )20 (r)-3 (epr)17 (oduc)4 (ed)20 ( i)6 (n any)4 ( f)2 (o)20 (r)-3 (m)37 ( )-20 (w)26 (i)-14 (t)2 (hout)2 ( t)2 (he)20 ( )20 (ex)24 (pr)-3 (es)4 (s)4 ( w)26 (r)-3 (i)-14 (t)2 (t)2 (en )]TJ -0.002 Tc 0.004 Tw [(p)-6 (e)14 (r)-9 (m)30.9 (i)-19.9 (s)-2 (s)-2 (i)-20 (o)-6 (n)-6 ( o)-6 (f)16 ( NCCN.)]TJ 0 Tc 0 Tw 11.04 -0 0 11.04 609.12 18.6 Tm ( )Tj EMC ET /Artifact <>BDC /CS0 CS 0 0.357 0.6 SCN 1.75 w 1 j q 1 0 0 1 22.5 532.8 cm 0 0 m 745.2 -0 l S Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc 0.005 Tw 18 -0 0 18 188.4 571.68 Tm [(N)-0.7 (C)-0.6 (C)-0.7 (N)-0.7 ( G)-4.7 (u)-5 (i)2 (d)-5 (el)2 (i)2 (n)-5 (es V)-2.3 (ersi)-4.6 (o)-5 (n)1.6 ( )]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 415.92 571.68 Tm (2)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 425.88 571.68 Tm (.)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 18 -0 0 18 431.04 571.68 Tm (2020)Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 471.48 571.68 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 0.009 Tc 18 -0 0 18 188.4 551.04 Tm [(Thy)11.7 (r)4.6 (oid)6.7 ( C)4.3 (a)5 (r)4.7 (c)5 (inom)4.7 (a)]TJ ET Q q 188.4 545.76 390.96 42.48 re W n BT 18 -0 0 18 354.12 551.04 Tm ( )Tj ET Q q 188.4 545.76 390.96 42.48 re W n BT /TT1 1 Tf 18 -0 0 18 188.4 530.28 Tm ( )Tj ET Q q 23.55 592.55 151.2 -50.4 re W n q /GS0 gs 151.1999937 0 0 50.3999988 23.5500755 542.149867 cm /Im1 Do Q EMC /Artifact <>BDC Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 0.004 Tc -0.004 Tw 11.04 -0 0 11.04 734.16 23.76 Tm (MS)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf 11.04 -0 0 11.04 750.72 23.76 Tm (-)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT /TT1 1 Tf -0.002 Tc 0.002 Tw 11.04 -0 0 11.04 754.44 23.76 Tm (74)Tj ET Q q 712.2 20.88 55.44 12.96 re W n BT 11.04 -0 0 11.04 766.56 24.24 Tm ( )Tj ET EMC Q BT /P <>BDC -0.002 Tc 0.007 Tw 11.04 -0 0 11.04 23.52 513.96 Tm [(546.)-6.7 ( K)2 (uns)8.9 (t)-6.6 (m)-6 (an)10.5 ( J)30.6 (W)-36.3 (,)4.3 ( )11.3 (J)-2 (uhl)2.6 (i)2.6 (n C)2.6 (C)2.7 (,)-6.6 ( )11.2 (G)-6.6 (oh )11.3 (G)4.3 (,)-6.7 ( e)10.6 (t)-6.6 ( al)2.6 (.)4.3 ( C)2.6 (har)4.9 (ac)-2 (t)-6.7 (er)-5.9 (i)2.6 (z)8.8 (at)-6.6 (i)2.6 (on o)10.5 (f)-6.6 ( t)-6.6 (he)10.6 ( )]TJ 0 -1.152 Td [(m)-6 (ut)-6.6 (a)10.5 (t)-6.6 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For personal use only. Not approved for distribution. 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endobj %% Original object ID: 9672 0 1402 0 obj << /K [ 6 3939 0 R 8 ] /P 153 0 R /Pg 115 0 R /S /P >> endobj %% Original object ID: 9673 0 1403 0 obj << /K [ 9 3940 0 R 11 ] /P 153 0 R /Pg 115 0 R /S /P >> endobj %% Original object ID: 9674 0 1404 0 obj << /K [ 12 3941 0 R 14 ] /P 153 0 R /Pg 115 0 R /S /P >> endobj %% Original object ID: 9675 0 1405 0 obj << /K [ 15 3942 0 R 17 ] /P 153 0 R /Pg 115 0 R /S /P >> endobj %% Original object ID: 9676 0 1406 0 obj << /K [ 18 3943 0 R 20 ] /P 153 0 R /Pg 115 0 R /S /P >> endobj %% Original object ID: 9677 0 1407 0 obj << /K [ 21 3944 0 R 23 ] /P 153 0 R /Pg 115 0 R /S /P >> endobj %% Original object ID: 9678 0 1408 0 obj << /K [ 24 3945 0 R 26 ] /P 153 0 R /Pg 115 0 R /S /P >> endobj %% Original object ID: 9679 0 1409 0 obj << /K [ 27 3946 0 R 29 ] /P 153 0 R /Pg 115 0 R /S /P >> endobj %% Original object ID: 9680 0 1410 0 obj << /K [ 30 3947 0 R 32 ] /P 153 0 R /Pg 115 0 R /S /P >> endobj %% Original object ID: 9681 0 1411 0 obj << /K [ 33 3948 0 R 35 ] /P 153 0 R /Pg 115 0 R /S /P >> endobj %% Original object ID: 9682 0 1412 0 obj << /K [ 36 3949 0 R 38 ] /P 153 0 R /Pg 115 0 R /S /P >> endobj %% Original object ID: 9683 0 1413 0 obj << /K [ 39 3950 0 R 41 ] /P 153 0 R /Pg 115 0 R /S /P >> endobj %% Original object ID: 9684 0 1414 0 obj << /K [ 42 3951 0 R 44 ] /P 153 0 R /Pg 115 0 R /S /P >> endobj %% Original object ID: 9685 0 1415 0 obj << /K [ 45 3952 0 R 47 ] /P 153 0 R /Pg 115 0 R /S /P >> endobj %% Original object ID: 9686 0 1416 0 obj << /K [ 48 << /MCID 0 /Pg 116 0 R /Type /MCR >> << /MCID 0 /Pg 116 0 R /Type /MCR >> << /MCID 0 /Pg 116 0 R /Type /MCR >> ] /P 153 0 R /Pg 115 0 R /S /P >> endobj %% Original object ID: 9687 0 1417 0 obj << /K [ 3 3953 0 R 5 ] /P 153 0 R /Pg 116 0 R /S /P >> endobj %% Original object ID: 9688 0 1418 0 obj << /K [ 6 3954 0 R 8 ] /P 153 0 R /Pg 116 0 R /S /P >> endobj %% Original object ID: 9689 0 1419 0 obj << /K [ 9 3955 0 R 11 ] /P 153 0 R /Pg 116 0 R /S /P >> endobj %% Original object ID: 9690 0 1420 0 obj << /K [ 12 3956 0 R 14 ] /P 153 0 R /Pg 116 0 R /S /P >> endobj %% Original object ID: 9691 0 1421 0 obj << /K [ 15 3957 0 R 17 ] /P 153 0 R /Pg 116 0 R /S /P >> endobj %% Original object ID: 9692 0 1422 0 obj << /K [ 18 3958 0 R 20 ] /P 153 0 R /Pg 116 0 R /S /P >> endobj %% Original object ID: 9693 0 1423 0 obj << /K [ 21 3959 0 R 23 ] /P 153 0 R /Pg 116 0 R /S /P >> endobj %% Original object ID: 9694 0 1424 0 obj << /K [ 24 3960 0 R 26 ] /P 153 0 R /Pg 116 0 R /S /P >> endobj %% Original object ID: 9695 0 1425 0 obj << /K [ 27 3961 0 R 29 ] /P 153 0 R /Pg 116 0 R /S /P >> endobj %% Original object ID: 9696 0 1426 0 obj << /K [ 30 3962 0 R 32 ] /P 153 0 R /Pg 116 0 R /S /P >> endobj %% Original object ID: 9697 0 1427 0 obj << /K 33 /P 153 0 R /Pg 116 0 R /S /P >> endobj %% Original object ID: 9698 0 1428 0 obj << /K [ 34 3963 0 R 36 ] /P 153 0 R /Pg 116 0 R /S /P >> endobj %% Original object ID: 9699 0 1429 0 obj << /K [ 37 3964 0 R 39 ] /P 153 0 R /Pg 116 0 R /S /P >> endobj %% Original object ID: 9700 0 1430 0 obj << /K [ 40 3965 0 R 42 ] /P 153 0 R /Pg 116 0 R /S /P >> endobj %% Original object ID: 9701 0 1431 0 obj << /K [ 43 3966 0 R 45 ] /P 153 0 R /Pg 116 0 R /S /P >> endobj %% Original object ID: 9702 0 1432 0 obj << /K [ 46 3967 0 R 48 ] /P 153 0 R /Pg 116 0 R /S /P >> endobj %% Original object ID: 9703 0 1433 0 obj << /K [ 0 3968 0 R 2 ] /P 153 0 R /Pg 117 0 R /S /P >> endobj %% Original object ID: 9704 0 1434 0 obj << /K [ 3 3969 0 R 5 ] /P 153 0 R /Pg 117 0 R /S /P >> endobj %% Original object ID: 9705 0 1435 0 obj << /K [ 6 3970 0 R 8 ] /P 153 0 R /Pg 117 0 R /S /P >> endobj %% Original object ID: 9706 0 1436 0 obj << /K [ 9 3971 0 R 11 ] /P 153 0 R /Pg 117 0 R /S /P >> endobj %% Original object ID: 9707 0 1437 0 obj << /K [ 12 3972 0 R 14 ] /P 153 0 R /Pg 117 0 R /S /P >> endobj %% Original object ID: 9708 0 1438 0 obj << /K [ 15 3973 0 R 17 ] /P 153 0 R /Pg 117 0 R /S /P >> endobj %% Original object ID: 9709 0 1439 0 obj << /K [ 18 3974 0 R 20 ] /P 153 0 R /Pg 117 0 R /S /P >> endobj %% Original object ID: 9710 0 1440 0 obj << /K [ 21 3975 0 R 23 ] /P 153 0 R /Pg 117 0 R /S /P >> endobj %% Original object ID: 9711 0 1441 0 obj << /K [ 24 3976 0 R 26 ] /P 153 0 R /Pg 117 0 R /S /P >> endobj %% Original object ID: 9712 0 1442 0 obj << /K [ 27 3977 0 R 29 ] /P 153 0 R /Pg 117 0 R /S /P >> endobj %% Original object ID: 9713 0 1443 0 obj << /K [ 30 3978 0 R 32 ] /P 153 0 R /Pg 117 0 R /S /P >> endobj %% Original object ID: 9714 0 1444 0 obj << /K [ 33 3979 0 R 35 ] /P 153 0 R /Pg 117 0 R /S /P >> endobj %% Original object ID: 9715 0 1445 0 obj << /K [ 36 3980 0 R 38 ] /P 153 0 R /Pg 117 0 R /S /P >> endobj %% Original object ID: 9716 0 1446 0 obj << /K [ 39 3981 0 R 41 ] /P 153 0 R /Pg 117 0 R /S /P >> endobj %% Original object ID: 9717 0 1447 0 obj << /K [ 42 3982 0 R 44 ] /P 153 0 R /Pg 117 0 R /S /P >> endobj %% Original object ID: 9718 0 1448 0 obj << /K [ 45 << /MCID 0 /Pg 118 0 R /Type /MCR >> << /MCID 0 /Pg 118 0 R /Type /MCR >> << /MCID 0 /Pg 118 0 R /Type /MCR >> ] /P 153 0 R /Pg 117 0 R /S /P >> endobj %% Original object ID: 9719 0 1449 0 obj << /K [ 3 3983 0 R 5 ] /P 153 0 R /Pg 118 0 R /S /P >> endobj %% Original object ID: 9720 0 1450 0 obj << /K [ 6 3984 0 R 8 ] /P 153 0 R /Pg 118 0 R /S /P >> endobj %% Original object ID: 9721 0 1451 0 obj << /K [ 9 3985 0 R 11 ] /P 153 0 R /Pg 118 0 R /S /P >> endobj %% Original object ID: 9722 0 1452 0 obj << /K [ 12 3986 0 R 14 ] /P 153 0 R /Pg 118 0 R /S /P >> endobj %% Original object ID: 9723 0 1453 0 obj << /K [ 15 3987 0 R 17 ] /P 153 0 R /Pg 118 0 R /S /P >> endobj %% Original object ID: 9724 0 1454 0 obj << /K [ 18 3988 0 R 20 ] /P 153 0 R /Pg 118 0 R /S /P >> endobj %% Original object ID: 9725 0 1455 0 obj << /K [ 21 3989 0 R 23 ] /P 153 0 R /Pg 118 0 R /S /P >> endobj %% Original object ID: 9726 0 1456 0 obj << /K [ 24 3990 0 R 26 ] /P 153 0 R /Pg 118 0 R /S /P >> endobj %% Original object ID: 9727 0 1457 0 obj << /K [ 27 3991 0 R 29 ] /P 153 0 R /Pg 118 0 R /S /P >> endobj %% Original object ID: 9728 0 1458 0 obj << /K [ 30 3992 0 R 32 ] /P 153 0 R /Pg 118 0 R /S /P >> endobj %% Original object ID: 9729 0 1459 0 obj << /K [ 33 3993 0 R 35 ] /P 153 0 R /Pg 118 0 R /S /P >> endobj %% Original object ID: 9730 0 1460 0 obj << /K [ 36 3994 0 R 38 ] /P 153 0 R /Pg 118 0 R /S /P >> endobj %% Original object ID: 9731 0 1461 0 obj << /K [ 39 3995 0 R 41 ] /P 153 0 R /Pg 118 0 R /S /P >> endobj %% Original object ID: 9732 0 1462 0 obj << /K [ 42 3996 0 R 44 ] /P 153 0 R /Pg 118 0 R /S /P >> endobj %% Original object ID: 9733 0 1463 0 obj << /K [ 0 3997 0 R 2 ] /P 153 0 R /Pg 119 0 R /S /P >> endobj %% Original object ID: 9734 0 1464 0 obj << /K [ 3 3998 0 R 5 ] /P 153 0 R /Pg 119 0 R /S /P >> endobj %% Original object ID: 9735 0 1465 0 obj << /K [ 6 3999 0 R 8 ] /P 153 0 R /Pg 119 0 R /S /P >> endobj %% Original object ID: 9736 0 1466 0 obj << /K [ 9 4000 0 R 11 ] /P 153 0 R /Pg 119 0 R /S /P >> endobj %% Original object ID: 9737 0 1467 0 obj << /K [ 12 4001 0 R 14 ] /P 153 0 R /Pg 119 0 R /S /P >> endobj %% Original object ID: 9738 0 1468 0 obj << /K [ 15 4002 0 R 17 ] /P 153 0 R /Pg 119 0 R /S /P >> endobj %% Original object ID: 9739 0 1469 0 obj << /K [ 18 4003 0 R 20 ] /P 153 0 R /Pg 119 0 R /S /P >> endobj %% Original object ID: 9740 0 1470 0 obj << /K [ 21 4004 0 R 23 ] /P 153 0 R /Pg 119 0 R /S /P >> endobj %% Original object ID: 9741 0 1471 0 obj << /K [ 24 4005 0 R 26 ] /P 153 0 R /Pg 119 0 R /S /P >> endobj %% Original object ID: 9742 0 1472 0 obj << /K [ 27 4006 0 R 29 ] /P 153 0 R /Pg 119 0 R /S /P >> endobj %% Original object ID: 9743 0 1473 0 obj << /K [ 30 4007 0 R 32 ] /P 153 0 R /Pg 119 0 R /S /P >> endobj %% Original object ID: 9744 0 1474 0 obj << /K [ 33 4008 0 R 35 ] /P 153 0 R /Pg 119 0 R /S /P >> endobj %% Original object ID: 9745 0 1475 0 obj << /K [ 36 4009 0 R 38 ] /P 153 0 R /Pg 119 0 R /S /P >> endobj %% Original object ID: 9746 0 1476 0 obj << /K [ 39 4010 0 R 41 ] /P 153 0 R /Pg 119 0 R /S /P >> endobj %% Original object ID: 9747 0 1477 0 obj << /K [ 42 << /MCID 0 /Pg 120 0 R /Type /MCR >> << /MCID 0 /Pg 120 0 R /Type /MCR >> << /MCID 0 /Pg 120 0 R /Type /MCR >> ] /P 153 0 R /Pg 119 0 R /S /P >> endobj %% Original object ID: 9748 0 1478 0 obj << /K [ 3 4011 0 R 5 ] /P 153 0 R /Pg 120 0 R /S /P >> endobj %% Original object ID: 9749 0 1479 0 obj << /K [ 6 4012 0 R 8 ] /P 153 0 R /Pg 120 0 R /S /P >> endobj %% Original object ID: 9750 0 1480 0 obj << /K [ 9 4013 0 R 11 ] /P 153 0 R /Pg 120 0 R /S /P >> endobj %% Original object ID: 9751 0 1481 0 obj << /K [ 12 4014 0 R 14 ] /P 153 0 R /Pg 120 0 R /S /P >> endobj %% Original object ID: 9752 0 1482 0 obj << /K [ 15 4015 0 R 17 ] /P 153 0 R /Pg 120 0 R /S /P >> endobj %% Original object ID: 9753 0 1483 0 obj << /K [ 18 4016 0 R 20 ] /P 153 0 R /Pg 120 0 R /S /P >> endobj %% Original object ID: 9754 0 1484 0 obj << /K [ 21 4017 0 R 23 ] /P 153 0 R /Pg 120 0 R /S /P >> endobj %% Original object ID: 9755 0 1485 0 obj << /K [ 24 4018 0 R 26 ] /P 153 0 R /Pg 120 0 R /S /P >> endobj %% Original object ID: 9756 0 1486 0 obj << /K [ 27 4019 0 R 29 ] /P 153 0 R /Pg 120 0 R /S /P >> endobj %% Original object ID: 9757 0 1487 0 obj << /K [ 30 4020 0 R 32 ] /P 153 0 R /Pg 120 0 R /S /P >> endobj %% Original object ID: 9758 0 1488 0 obj << /K [ 33 4021 0 R 35 ] /P 153 0 R /Pg 120 0 R /S /P >> endobj %% Original object ID: 9759 0 1489 0 obj << /K [ 36 4022 0 R 38 ] /P 153 0 R /Pg 120 0 R /S /P >> endobj %% Original object ID: 9760 0 1490 0 obj << /K [ 39 4023 0 R 41 ] /P 153 0 R /Pg 120 0 R /S /P >> endobj %% Original object ID: 9761 0 1491 0 obj << /K [ 42 << /MCID 0 /Pg 121 0 R /Type /MCR >> << /MCID 0 /Pg 121 0 R /Type /MCR >> << /MCID 0 /Pg 121 0 R /Type /MCR >> ] /P 153 0 R /Pg 120 0 R /S /P >> endobj %% Original object ID: 9762 0 1492 0 obj << /K [ 3 4024 0 R 5 ] /P 153 0 R /Pg 121 0 R /S /P >> endobj %% Original object ID: 9763 0 1493 0 obj << /K [ 6 4025 0 R 8 ] /P 153 0 R /Pg 121 0 R /S /P >> endobj %% Original object ID: 9764 0 1494 0 obj << /K [ 9 4026 0 R 11 ] /P 153 0 R /Pg 121 0 R /S /P >> endobj %% Original object ID: 9765 0 1495 0 obj << /K [ 12 4027 0 R 14 ] /P 153 0 R /Pg 121 0 R /S /P >> endobj %% Original object ID: 9766 0 1496 0 obj << /K [ 15 4028 0 R 17 ] /P 153 0 R /Pg 121 0 R /S /P >> endobj %% Original object ID: 9767 0 1497 0 obj << /K 18 /P 153 0 R /Pg 121 0 R /S /P >> endobj %% Original object ID: 9768 0 1498 0 obj << /K [ 19 4029 0 R 21 ] /P 153 0 R /Pg 121 0 R /S /P >> endobj %% Original object ID: 9769 0 1499 0 obj << /K [ 22 4030 0 R 24 ] /P 153 0 R /Pg 121 0 R /S /P >> endobj %% Original object ID: 9770 0 1500 0 obj << /K [ 25 4031 0 R 27 ] /P 153 0 R /Pg 121 0 R /S /P >> endobj %% Original object ID: 9771 0 1501 0 obj << /K [ 28 4032 0 R 30 ] /P 153 0 R /Pg 121 0 R /S /P >> endobj %% Original object ID: 9772 0 1502 0 obj << /K [ 31 4033 0 R 33 ] /P 153 0 R /Pg 121 0 R /S /P >> endobj %% Original object ID: 9773 0 1503 0 obj << /K [ 34 4034 0 R 36 ] /P 153 0 R /Pg 121 0 R /S /P >> endobj %% Original object ID: 9774 0 1504 0 obj << /K [ 37 4035 0 R 39 ] /P 153 0 R /Pg 121 0 R /S /P >> endobj %% Original object ID: 9775 0 1505 0 obj << /K [ 40 4036 0 R 42 ] /P 153 0 R /Pg 121 0 R /S /P >> endobj %% Original object ID: 9776 0 1506 0 obj << /K [ 43 << /MCID 0 /Pg 122 0 R /Type /MCR >> << /MCID 0 /Pg 122 0 R /Type /MCR >> << /MCID 0 /Pg 122 0 R /Type /MCR >> ] /P 153 0 R /Pg 121 0 R /S /P >> endobj %% Original object ID: 9777 0 1507 0 obj << /K [ 3 4037 0 R 5 ] /P 153 0 R /Pg 122 0 R /S /P >> endobj %% Original object ID: 9778 0 1508 0 obj << /K [ 6 4038 0 R 8 ] /P 153 0 R /Pg 122 0 R /S /P >> endobj %% Original object ID: 9779 0 1509 0 obj << /K [ 9 4039 0 R 11 ] /P 153 0 R /Pg 122 0 R /S /P >> endobj %% Original object ID: 9780 0 1510 0 obj << /K [ 12 4040 0 R 14 ] /P 153 0 R /Pg 122 0 R /S /P >> endobj %% Original object ID: 9781 0 1511 0 obj << /K [ 15 4041 0 R 17 ] /P 153 0 R /Pg 122 0 R /S /P >> endobj %% Original object ID: 9782 0 1512 0 obj << /K [ 18 4042 0 R 20 ] /P 153 0 R /Pg 122 0 R /S /P >> endobj %% Original object ID: 9783 0 1513 0 obj << /K [ 21 4043 0 R 23 ] /P 153 0 R /Pg 122 0 R /S /P >> endobj %% Original object ID: 9784 0 1514 0 obj << /K [ 24 4044 0 R 26 ] /P 153 0 R /Pg 122 0 R /S /P >> endobj %% Original object ID: 9785 0 1515 0 obj << /K [ 27 4045 0 R 29 ] /P 153 0 R /Pg 122 0 R /S /P >> endobj %% Original object ID: 9786 0 1516 0 obj << /K [ 30 4046 0 R 32 ] /P 153 0 R /Pg 122 0 R /S /P >> endobj %% Original object ID: 9787 0 1517 0 obj << /K [ 33 4047 0 R 35 ] /P 153 0 R /Pg 122 0 R /S /P >> endobj %% Original object ID: 9788 0 1518 0 obj << /K [ 36 4048 0 R 38 ] /P 153 0 R /Pg 122 0 R /S /P >> endobj %% Original object ID: 9789 0 1519 0 obj << /K [ 39 4049 0 R 41 ] /P 153 0 R /Pg 122 0 R /S /P >> endobj %% Original object ID: 9790 0 1520 0 obj << /K [ 42 << /MCID 0 /Pg 123 0 R /Type /MCR >> << /MCID 0 /Pg 123 0 R /Type /MCR >> << /MCID 0 /Pg 123 0 R /Type /MCR >> ] /P 153 0 R /Pg 122 0 R /S /P >> endobj %% Original object ID: 9791 0 1521 0 obj << /K [ 3 4050 0 R 5 ] /P 153 0 R /Pg 123 0 R /S /P >> endobj %% Original object ID: 9792 0 1522 0 obj << /K [ 6 4051 0 R 8 ] /P 153 0 R /Pg 123 0 R /S /P >> endobj %% Original object ID: 9793 0 1523 0 obj << /K [ 9 4052 0 R 11 ] /P 153 0 R /Pg 123 0 R /S /P >> endobj %% Original object ID: 9794 0 1524 0 obj << /K [ 12 4053 0 R 14 ] /P 153 0 R /Pg 123 0 R /S /P >> endobj %% Original object ID: 9795 0 1525 0 obj << /K [ 15 4054 0 R 17 ] /P 153 0 R /Pg 123 0 R /S /P >> endobj %% Original object ID: 9796 0 1526 0 obj << /K [ 18 4055 0 R 20 ] /P 153 0 R /Pg 123 0 R /S /P >> endobj %% Original object ID: 9797 0 1527 0 obj << /K [ 21 4056 0 R 23 ] /P 153 0 R /Pg 123 0 R /S /P >> endobj %% Original object ID: 9798 0 1528 0 obj << /K [ 24 4057 0 R 26 ] /P 153 0 R /Pg 123 0 R /S /P >> endobj %% Original object ID: 9799 0 1529 0 obj << /K [ 27 4058 0 R 29 ] /P 153 0 R /Pg 123 0 R /S /P >> endobj %% Original object ID: 9800 0 1530 0 obj << /K [ 30 4059 0 R 32 ] /P 153 0 R /Pg 123 0 R /S /P >> endobj %% Original object ID: 9801 0 1531 0 obj << /K [ 33 4060 0 R 35 ] /P 153 0 R /Pg 123 0 R /S /P >> endobj %% Original object ID: 9802 0 1532 0 obj << /K 36 /P 153 0 R /Pg 123 0 R /S /P >> endobj %% Original object ID: 9803 0 1533 0 obj << /K 37 /P 153 0 R /Pg 123 0 R /S /P >> endobj %% Original object ID: 9804 0 1534 0 obj << /K [ 38 4061 0 R 40 ] /P 153 0 R /Pg 123 0 R /S /P >> endobj %% Original object ID: 9805 0 1535 0 obj << /K [ 41 4062 0 R 43 ] /P 153 0 R /Pg 123 0 R /S /P >> endobj %% Original object ID: 9806 0 1536 0 obj << /K [ 44 4063 0 R 46 ] /P 153 0 R /Pg 123 0 R /S /P >> endobj %% Original object ID: 9807 0 1537 0 obj << /K [ 47 4064 0 R 49 ] /P 153 0 R /Pg 123 0 R /S /P >> endobj %% Original object ID: 9808 0 1538 0 obj << /K [ 0 4065 0 R 2 ] /P 153 0 R /Pg 124 0 R /S /P >> endobj %% Original object ID: 9809 0 1539 0 obj << /K [ 3 4066 0 R 5 ] /P 153 0 R /Pg 124 0 R /S /P >> endobj %% Original object ID: 9810 0 1540 0 obj << /K 6 /P 153 0 R /Pg 124 0 R /S /P >> endobj %% Original object ID: 9811 0 1541 0 obj << /K [ 7 4067 0 R 9 ] /P 153 0 R /Pg 124 0 R /S /P >> endobj %% Original object ID: 9812 0 1542 0 obj << /K [ 10 4068 0 R 12 ] /P 153 0 R /Pg 124 0 R /S /P >> endobj %% Original object ID: 9813 0 1543 0 obj << /K [ 13 4069 0 R 15 ] /P 153 0 R /Pg 124 0 R /S /P >> endobj %% Original object ID: 9814 0 1544 0 obj << /K [ 16 4070 0 R 18 ] /P 153 0 R /Pg 124 0 R /S /P >> endobj %% Original object ID: 9815 0 1545 0 obj << /K [ 19 4071 0 R 21 ] /P 153 0 R /Pg 124 0 R /S /P >> endobj %% Original object ID: 9816 0 1546 0 obj << /K [ 22 4072 0 R 24 ] /P 153 0 R /Pg 124 0 R /S /P >> endobj %% Original object ID: 9817 0 1547 0 obj << /K [ 25 4073 0 R 27 ] /P 153 0 R /Pg 124 0 R /S /P >> endobj %% Original object ID: 9818 0 1548 0 obj << /K [ 28 4074 0 R 30 ] /P 153 0 R /Pg 124 0 R /S /P >> endobj %% Original object ID: 9819 0 1549 0 obj << /K [ 31 4075 0 R 33 ] /P 153 0 R /Pg 124 0 R /S /P >> endobj %% Original object ID: 9820 0 1550 0 obj << /K [ 34 4076 0 R 36 ] /P 153 0 R /Pg 124 0 R /S /P >> endobj %% Original object ID: 9821 0 1551 0 obj << /K [ 37 4077 0 R 39 ] /P 153 0 R /Pg 124 0 R /S /P >> endobj %% Original object ID: 9822 0 1552 0 obj << /K [ 40 4078 0 R 42 ] /P 153 0 R /Pg 124 0 R /S /P >> endobj %% Original object ID: 9823 0 1553 0 obj << /K [ 43 4079 0 R 45 ] /P 153 0 R /Pg 124 0 R /S /P >> endobj %% Original object ID: 9824 0 1554 0 obj << /K 0 /P 153 0 R /Pg 125 0 R /S /P >> endobj %% Original object ID: 9825 0 1555 0 obj << /K [ 1 4080 0 R 3 ] /P 153 0 R /Pg 125 0 R /S /P >> endobj %% Original object ID: 9826 0 1556 0 obj << /K [ 4 4081 0 R 6 ] /P 153 0 R /Pg 125 0 R /S /P >> endobj %% Original object ID: 9827 0 1557 0 obj << /K [ 7 4082 0 R 9 ] /P 153 0 R /Pg 125 0 R /S /P >> endobj %% Original object ID: 9828 0 1558 0 obj << /K [ 10 4083 0 R 12 ] /P 153 0 R /Pg 125 0 R /S /P >> endobj %% Original object ID: 9829 0 1559 0 obj << /K [ 13 4084 0 R 15 ] /P 153 0 R /Pg 125 0 R /S /P >> endobj %% Original object ID: 9830 0 1560 0 obj << /K [ 16 4085 0 R 18 ] /P 153 0 R /Pg 125 0 R /S /P >> endobj %% Original object ID: 9831 0 1561 0 obj << /K [ 19 4086 0 R 21 ] /P 153 0 R /Pg 125 0 R /S /P >> endobj %% Original object ID: 9832 0 1562 0 obj << /K [ 22 4087 0 R 24 ] /P 153 0 R /Pg 125 0 R /S /P >> endobj %% Original object ID: 9833 0 1563 0 obj << /K [ 25 4088 0 R 27 ] /P 153 0 R /Pg 125 0 R /S /P >> endobj %% Original object ID: 9834 0 1564 0 obj << /K [ 28 4089 0 R 30 ] /P 153 0 R /Pg 125 0 R /S /P >> endobj %% Original object ID: 9835 0 1565 0 obj << /K [ 31 4090 0 R 33 ] /P 153 0 R /Pg 125 0 R /S /P >> endobj %% Original object ID: 9836 0 1566 0 obj << /K [ 34 4091 0 R 36 ] /P 153 0 R /Pg 125 0 R /S /P >> endobj %% Original object ID: 9837 0 1567 0 obj << /K [ 37 4092 0 R 39 ] /P 153 0 R /Pg 125 0 R /S /P >> endobj %% Original object ID: 9838 0 1568 0 obj << /K [ 40 4093 0 R 42 ] /P 153 0 R /Pg 125 0 R /S /P >> endobj %% Original object ID: 9839 0 1569 0 obj << /K [ 43 4094 0 R 45 ] /P 153 0 R /Pg 125 0 R /S /P >> endobj %% Original object ID: 9840 0 1570 0 obj << /K [ 0 4095 0 R 2 ] /P 153 0 R /Pg 126 0 R /S /P >> endobj %% Original object ID: 9841 0 1571 0 obj << /K [ 3 4096 0 R 5 ] /P 153 0 R /Pg 126 0 R /S /P >> endobj %% Original object ID: 9842 0 1572 0 obj << /K [ 6 4097 0 R 8 ] /P 153 0 R /Pg 126 0 R /S /P >> endobj %% Original object ID: 9843 0 1573 0 obj << /K [ 9 4098 0 R 11 ] /P 153 0 R /Pg 126 0 R /S /P >> endobj %% Original object ID: 9844 0 1574 0 obj << /K [ 12 4099 0 R 14 ] /P 153 0 R /Pg 126 0 R /S /P >> endobj %% Original object ID: 9845 0 1575 0 obj << /K [ 15 4100 0 R 17 ] /P 153 0 R /Pg 126 0 R /S /P >> endobj %% Original object ID: 9846 0 1576 0 obj << /K [ 18 4101 0 R 20 ] /P 153 0 R /Pg 126 0 R /S /P >> endobj %% Original object ID: 9847 0 1577 0 obj << /K [ 21 4102 0 R 23 ] /P 153 0 R /Pg 126 0 R /S /P >> endobj %% Original object ID: 9848 0 1578 0 obj << /K [ 24 4103 0 R 26 ] /P 153 0 R /Pg 126 0 R /S /P >> endobj %% Original object ID: 9849 0 1579 0 obj << /K [ 27 4104 0 R 29 ] /P 153 0 R /Pg 126 0 R /S /P >> endobj %% Original object ID: 9850 0 1580 0 obj << /K [ 30 4105 0 R 32 ] /P 153 0 R /Pg 126 0 R /S /P >> endobj %% Original object ID: 9851 0 1581 0 obj << /K [ 33 4106 0 R 35 ] /P 153 0 R /Pg 126 0 R /S /P >> endobj %% Original object ID: 9852 0 1582 0 obj << /K [ 36 4107 0 R 38 ] /P 153 0 R /Pg 126 0 R /S /P >> endobj %% Original object ID: 9853 0 1583 0 obj << /K 39 /P 153 0 R /Pg 126 0 R /S /P >> endobj %% Original object ID: 9854 0 1584 0 obj << /K 40 /P 153 0 R /Pg 126 0 R /S /P >> endobj %% Original object ID: 9855 0 1585 0 obj << /K 41 /P 153 0 R /Pg 126 0 R /S /P >> endobj %% Original object ID: 9856 0 1586 0 obj << /K [ 0 4108 0 R 2 ] /P 153 0 R /Pg 127 0 R /S /P >> endobj %% Original object ID: 9857 0 1587 0 obj << /K [ 3 4109 0 R 5 ] /P 153 0 R /Pg 127 0 R /S /P >> endobj %% Original object ID: 9858 0 1588 0 obj << /K [ 6 4110 0 R 8 ] /P 153 0 R /Pg 127 0 R /S /P >> endobj %% Original object ID: 9859 0 1589 0 obj << /K [ 9 4111 0 R 11 ] /P 153 0 R /Pg 127 0 R /S /P >> endobj %% Original object ID: 9860 0 1590 0 obj << /K [ 12 4112 0 R 14 ] /P 153 0 R /Pg 127 0 R /S /P >> endobj %% Original object ID: 9861 0 1591 0 obj << /K [ 15 4113 0 R 17 ] /P 153 0 R /Pg 127 0 R /S /P >> endobj %% Original object ID: 9862 0 1592 0 obj << /K [ 18 4114 0 R 20 ] /P 153 0 R /Pg 127 0 R /S /P >> endobj %% Original object ID: 9863 0 1593 0 obj << /K [ 21 4115 0 R 23 ] /P 153 0 R /Pg 127 0 R /S /P >> endobj %% Original object ID: 9864 0 1594 0 obj << /K [ 24 4116 0 R 26 ] /P 153 0 R /Pg 127 0 R /S /P >> endobj %% Original object ID: 9865 0 1595 0 obj << /K [ 27 4117 0 R 29 ] /P 153 0 R /Pg 127 0 R /S /P >> endobj %% Original object ID: 9866 0 1596 0 obj << /K [ 30 4118 0 R 32 ] /P 153 0 R /Pg 127 0 R /S /P >> endobj %% Original object ID: 9867 0 1597 0 obj << /K [ 33 4119 0 R 35 ] /P 153 0 R /Pg 127 0 R /S /P >> endobj %% Original object ID: 9868 0 1598 0 obj << /K [ 36 4120 0 R 38 ] /P 153 0 R /Pg 127 0 R /S /P >> endobj %% Original object ID: 9869 0 1599 0 obj << /K [ 39 4121 0 R 41 ] /P 153 0 R /Pg 127 0 R /S /P >> endobj %% Original object ID: 9870 0 1600 0 obj << /K [ 42 4122 0 R 44 ] /P 153 0 R /Pg 127 0 R /S /P >> endobj %% Original object ID: 9871 0 1601 0 obj << /K [ 0 4123 0 R 2 ] /P 153 0 R /Pg 128 0 R /S /P >> endobj %% Original object ID: 9872 0 1602 0 obj << /K [ 3 4124 0 R 5 ] /P 153 0 R /Pg 128 0 R /S /P >> endobj %% Original object ID: 9873 0 1603 0 obj << /K [ 6 4125 0 R 8 ] /P 153 0 R /Pg 128 0 R /S /P >> endobj %% Original object ID: 9874 0 1604 0 obj << /K [ 9 4126 0 R 11 ] /P 153 0 R /Pg 128 0 R /S /P >> endobj %% Original object ID: 9875 0 1605 0 obj << /K [ 12 4127 0 R 14 ] /P 153 0 R /Pg 128 0 R /S /P >> endobj %% Original object ID: 9876 0 1606 0 obj << /K [ 15 4128 0 R 17 ] /P 153 0 R /Pg 128 0 R /S /P >> endobj %% Original object ID: 9877 0 1607 0 obj << /K [ 18 4129 0 R 20 ] /P 153 0 R /Pg 128 0 R /S /P >> endobj %% Original object ID: 9878 0 1608 0 obj << /K [ 21 4130 0 R 23 ] /P 153 0 R /Pg 128 0 R /S /P >> endobj %% Original object ID: 9879 0 1609 0 obj << /K [ 24 4131 0 R 26 ] /P 153 0 R /Pg 128 0 R /S /P >> endobj %% Original object ID: 9880 0 1610 0 obj << /K [ 27 4132 0 R 29 ] /P 153 0 R /Pg 128 0 R /S /P >> endobj %% Original object ID: 9881 0 1611 0 obj << /K [ 30 4133 0 R 32 ] /P 153 0 R /Pg 128 0 R /S /P >> endobj %% Original object ID: 9882 0 1612 0 obj << /K [ 33 4134 0 R 35 ] /P 153 0 R /Pg 128 0 R /S /P >> endobj %% Original object ID: 9883 0 1613 0 obj << /K [ 36 4135 0 R 38 ] /P 153 0 R /Pg 128 0 R /S /P >> endobj %% Original object ID: 9884 0 1614 0 obj << /K [ 39 4136 0 R 41 ] /P 153 0 R /Pg 128 0 R /S /P >> endobj %% Original object ID: 9885 0 1615 0 obj << /K [ 42 4137 0 R 44 ] /P 153 0 R /Pg 128 0 R /S /P >> endobj %% Original object ID: 9886 0 1616 0 obj << /K [ 45 4138 0 R 47 ] /P 153 0 R /Pg 128 0 R /S /P >> endobj %% Original object ID: 9887 0 1617 0 obj << /K [ 0 4139 0 R 2 ] /P 153 0 R /Pg 129 0 R /S /P >> endobj %% Original object ID: 9888 0 1618 0 obj << /K [ 3 4140 0 R 5 ] /P 153 0 R /Pg 129 0 R /S /P >> endobj %% Original object ID: 9889 0 1619 0 obj << /K [ 6 4141 0 R 8 ] /P 153 0 R /Pg 129 0 R /S /P >> endobj %% Original object ID: 9890 0 1620 0 obj << /K [ 9 4142 0 R 11 ] /P 153 0 R /Pg 129 0 R /S /P >> endobj %% Original object ID: 9891 0 1621 0 obj << /K [ 12 4143 0 R 14 ] /P 153 0 R /Pg 129 0 R /S /P >> endobj %% Original object ID: 9892 0 1622 0 obj << /K [ 15 4144 0 R 17 ] /P 153 0 R /Pg 129 0 R /S /P >> endobj %% Original object ID: 9893 0 1623 0 obj << /K [ 18 4145 0 R 20 ] /P 153 0 R /Pg 129 0 R /S /P >> endobj %% Original object ID: 9894 0 1624 0 obj << /K [ 21 4146 0 R 23 ] /P 153 0 R /Pg 129 0 R /S /P >> endobj %% Original object ID: 9895 0 1625 0 obj << /K [ 24 4147 0 R 26 ] /P 153 0 R /Pg 129 0 R /S /P >> endobj %% Original object ID: 9896 0 1626 0 obj << /K [ 27 4148 0 R 29 ] /P 153 0 R /Pg 129 0 R /S /P >> endobj %% Original object ID: 9897 0 1627 0 obj << /K 30 /P 153 0 R /Pg 129 0 R /S /P >> endobj %% Original object ID: 9898 0 1628 0 obj << /K 31 /P 153 0 R /Pg 129 0 R /S /P >> endobj %% Original object ID: 9899 0 1629 0 obj << /K [ 32 4149 0 R 34 ] /P 153 0 R /Pg 129 0 R /S /P >> endobj %% Original object ID: 9900 0 1630 0 obj << /K [ 35 4150 0 R 37 ] /P 153 0 R /Pg 129 0 R /S /P >> endobj %% Original object ID: 9901 0 1631 0 obj << /K [ 38 4151 0 R 40 ] /P 153 0 R /Pg 129 0 R /S /P >> endobj %% Original object ID: 9902 0 1632 0 obj << /K [ 41 4152 0 R 43 ] /P 153 0 R /Pg 129 0 R /S /P >> endobj %% Original object ID: 9903 0 1633 0 obj << /K [ 0 4153 0 R 2 ] /P 153 0 R /Pg 130 0 R /S /P >> endobj %% Original object ID: 9904 0 1634 0 obj << /K [ 3 4154 0 R 5 ] /P 153 0 R /Pg 130 0 R /S /P >> endobj %% Original object ID: 9905 0 1635 0 obj << /K [ 6 4155 0 R 8 ] /P 153 0 R /Pg 130 0 R /S /P >> endobj %% Original object ID: 9906 0 1636 0 obj << /K [ 9 4156 0 R 11 ] /P 153 0 R /Pg 130 0 R /S /P >> endobj %% Original object ID: 9907 0 1637 0 obj << /K [ 12 4157 0 R 14 ] /P 153 0 R /Pg 130 0 R /S /P >> endobj %% Original object ID: 9908 0 1638 0 obj << /K [ 15 4158 0 R 17 ] /P 153 0 R /Pg 130 0 R /S /P >> endobj %% Original object ID: 9909 0 1639 0 obj << /K [ 18 4159 0 R 20 ] /P 153 0 R /Pg 130 0 R /S /P >> endobj %% Original object ID: 9910 0 1640 0 obj << /K [ 21 4160 0 R 23 ] /P 153 0 R /Pg 130 0 R /S /P >> endobj %% Original object ID: 9911 0 1641 0 obj << /K [ 24 4161 0 R 26 ] /P 153 0 R /Pg 130 0 R /S /P >> endobj %% Original object ID: 9912 0 1642 0 obj << /K [ 27 4162 0 R 29 ] /P 153 0 R /Pg 130 0 R /S /P >> endobj %% Original object ID: 9913 0 1643 0 obj << /K [ 30 4163 0 R 32 ] /P 153 0 R /Pg 130 0 R /S /P >> endobj %% Original object ID: 9914 0 1644 0 obj << /K [ 33 4164 0 R 35 ] /P 153 0 R /Pg 130 0 R /S /P >> endobj %% Original object ID: 9915 0 1645 0 obj << /K [ 36 4165 0 R 38 ] /P 153 0 R /Pg 130 0 R /S /P >> endobj %% Original object ID: 9916 0 1646 0 obj << /K [ 39 4166 0 R 41 ] /P 153 0 R /Pg 130 0 R /S /P >> endobj %% Original object ID: 9917 0 1647 0 obj << /K 42 /P 153 0 R /Pg 130 0 R /S /P >> endobj %% Original object ID: 9918 0 1648 0 obj << /K [ 43 4167 0 R 45 ] /P 153 0 R /Pg 130 0 R /S /P >> endobj %% Original object ID: 9919 0 1649 0 obj << /K [ 0 4168 0 R 2 ] /P 153 0 R /Pg 131 0 R /S /P >> endobj %% Original object ID: 9920 0 1650 0 obj << /K [ 3 4169 0 R 5 ] /P 153 0 R /Pg 131 0 R /S /P >> endobj %% Original object ID: 9921 0 1651 0 obj << /K [ 6 4170 0 R 8 ] /P 153 0 R /Pg 131 0 R /S /P >> endobj %% Original object ID: 9922 0 1652 0 obj << /K [ 9 4171 0 R 11 ] /P 153 0 R /Pg 131 0 R /S /P >> endobj %% Original object ID: 9923 0 1653 0 obj << /K [ 12 4172 0 R 14 ] /P 153 0 R /Pg 131 0 R /S /P >> endobj %% Original object ID: 9924 0 1654 0 obj << /K [ 15 4173 0 R 17 ] /P 153 0 R /Pg 131 0 R /S /P >> endobj %% Original object ID: 9925 0 1655 0 obj << /K [ 18 4174 0 R 20 ] /P 153 0 R /Pg 131 0 R /S /P >> endobj %% Original object ID: 9926 0 1656 0 obj << /K [ 21 4175 0 R 23 ] /P 153 0 R /Pg 131 0 R /S /P >> endobj %% Original object ID: 9927 0 1657 0 obj << /K [ 24 4176 0 R 26 ] /P 153 0 R /Pg 131 0 R /S /P >> endobj %% Original object ID: 9928 0 1658 0 obj << /K [ 27 4177 0 R 29 ] /P 153 0 R /Pg 131 0 R /S /P >> endobj %% Original object ID: 9929 0 1659 0 obj << /K [ 30 4178 0 R 32 ] /P 153 0 R /Pg 131 0 R /S /P >> endobj %% Original object ID: 9930 0 1660 0 obj << /K [ 33 4179 0 R 35 ] /P 153 0 R /Pg 131 0 R /S /P >> endobj %% Original object ID: 9931 0 1661 0 obj << /K [ 36 4180 0 R 38 ] /P 153 0 R /Pg 131 0 R /S /P >> endobj %% Original object ID: 9932 0 1662 0 obj << /K [ 39 4181 0 R 41 ] /P 153 0 R /Pg 131 0 R /S /P >> endobj %% Original object ID: 9933 0 1663 0 obj << /K [ 42 << /MCID 0 /Pg 132 0 R /Type /MCR >> << /MCID 0 /Pg 132 0 R /Type /MCR >> << /MCID 0 /Pg 132 0 R /Type /MCR >> ] /P 153 0 R /Pg 131 0 R /S /P >> endobj %% Original object ID: 9934 0 1664 0 obj << /K [ 3 4182 0 R 5 ] /P 153 0 R /Pg 132 0 R /S /P >> endobj %% Original object ID: 9935 0 1665 0 obj << /K [ 6 4183 0 R 8 ] /P 153 0 R /Pg 132 0 R /S /P >> endobj %% Original object ID: 9936 0 1666 0 obj << /K [ 9 4184 0 R 11 ] /P 153 0 R /Pg 132 0 R /S /P >> endobj %% Original object ID: 9937 0 1667 0 obj << /K [ 12 4185 0 R 14 ] /P 153 0 R /Pg 132 0 R /S /P >> endobj %% Original object ID: 9938 0 1668 0 obj << /K [ 15 4186 0 R 17 ] /P 153 0 R /Pg 132 0 R /S /P >> endobj %% Original object ID: 9939 0 1669 0 obj << /K [ 18 4187 0 R 20 ] /P 153 0 R /Pg 132 0 R /S /P >> endobj %% Original object ID: 9940 0 1670 0 obj << /K [ 21 4188 0 R 23 ] /P 153 0 R /Pg 132 0 R /S /P >> endobj %% Original object ID: 9941 0 1671 0 obj << /K [ 24 4189 0 R 26 ] /P 153 0 R /Pg 132 0 R /S /P >> endobj %% Original object ID: 9942 0 1672 0 obj << /K [ 27 4190 0 R 29 ] /P 153 0 R /Pg 132 0 R /S /P >> endobj %% Original object ID: 9943 0 1673 0 obj << /K [ 30 4191 0 R 32 ] /P 153 0 R /Pg 132 0 R /S /P >> endobj %% Original object ID: 9944 0 1674 0 obj << /K [ 33 4192 0 R 35 ] /P 153 0 R /Pg 132 0 R /S /P >> endobj %% Original object ID: 9945 0 1675 0 obj << /K [ 36 4193 0 R 38 ] /P 153 0 R /Pg 132 0 R /S /P >> endobj %% Original object ID: 9946 0 1676 0 obj << /K [ 39 4194 0 R 41 ] /P 153 0 R /Pg 132 0 R /S /P >> endobj %% Original object ID: 9947 0 1677 0 obj << /K [ 42 4195 0 R 44 ] /P 153 0 R /Pg 132 0 R /S /P >> endobj %% Original object ID: 9948 0 1678 0 obj << /K [ 45 << /MCID 0 /Pg 133 0 R /Type /MCR >> << /MCID 0 /Pg 133 0 R /Type /MCR >> << /MCID 0 /Pg 133 0 R /Type /MCR >> ] /P 153 0 R /Pg 132 0 R /S /P >> endobj %% Original object ID: 9949 0 1679 0 obj << /K [ 3 4196 0 R 5 ] /P 153 0 R /Pg 133 0 R /S /P >> endobj %% Original object ID: 9950 0 1680 0 obj << /K [ 6 4197 0 R 8 ] /P 153 0 R /Pg 133 0 R /S /P >> endobj %% Original object ID: 9951 0 1681 0 obj << /K [ 9 4198 0 R 11 ] /P 153 0 R /Pg 133 0 R /S /P >> endobj %% Original object ID: 9952 0 1682 0 obj << /K [ 12 4199 0 R 14 ] /P 153 0 R /Pg 133 0 R /S /P >> endobj %% Original object ID: 9953 0 1683 0 obj << /K [ 15 4200 0 R 17 ] /P 153 0 R /Pg 133 0 R /S /P >> endobj %% Original object ID: 9954 0 1684 0 obj << /K [ 18 4201 0 R 20 ] /P 153 0 R /Pg 133 0 R /S /P >> endobj %% Original object ID: 9955 0 1685 0 obj << /K [ 21 4202 0 R 23 ] /P 153 0 R /Pg 133 0 R /S /P >> endobj %% Original object ID: 9956 0 1686 0 obj << /K [ 24 4203 0 R 26 ] /P 153 0 R /Pg 133 0 R /S /P >> endobj %% Original object ID: 9957 0 1687 0 obj << /K [ 27 4204 0 R 29 ] /P 153 0 R /Pg 133 0 R /S /P >> endobj %% Original object ID: 9958 0 1688 0 obj << /K [ 30 4205 0 R 32 ] /P 153 0 R /Pg 133 0 R /S /P >> endobj %% Original object ID: 9959 0 1689 0 obj << /K [ 33 4206 0 R 35 ] /P 153 0 R /Pg 133 0 R /S /P >> endobj %% Original object ID: 9960 0 1690 0 obj << /K [ 36 4207 0 R 38 ] /P 153 0 R /Pg 133 0 R /S /P >> endobj %% Original object ID: 9961 0 1691 0 obj << /K [ 39 4208 0 R 41 ] /P 153 0 R /Pg 133 0 R /S /P >> endobj %% Original object ID: 9962 0 1692 0 obj << /K [ 42 4209 0 R 44 ] /P 153 0 R /Pg 133 0 R /S /P >> endobj %% Original object ID: 9963 0 1693 0 obj << /K [ 45 << /MCID 0 /Pg 134 0 R /Type /MCR >> << /MCID 0 /Pg 134 0 R /Type /MCR >> << /MCID 0 /Pg 134 0 R /Type /MCR >> ] /P 153 0 R /Pg 133 0 R /S /P >> endobj %% Original object ID: 9964 0 1694 0 obj << /K [ 3 4210 0 R 5 ] /P 153 0 R /Pg 134 0 R /S /P >> endobj %% Original object ID: 9965 0 1695 0 obj << /K [ 6 4211 0 R 8 ] /P 153 0 R /Pg 134 0 R /S /P >> endobj %% Original object ID: 9966 0 1696 0 obj << /K [ 9 4212 0 R 11 ] /P 153 0 R /Pg 134 0 R /S /P >> endobj %% Original object ID: 9967 0 1697 0 obj << /K [ 12 4213 0 R 14 ] /P 153 0 R /Pg 134 0 R /S /P >> endobj %% Original object ID: 9968 0 1698 0 obj << /K [ 15 4214 0 R 17 ] /P 153 0 R /Pg 134 0 R /S /P >> endobj %% Original object ID: 9969 0 1699 0 obj << /K [ 18 4215 0 R 20 ] /P 153 0 R /Pg 134 0 R /S /P >> endobj %% Original object ID: 9970 0 1700 0 obj << /K [ 21 4216 0 R 23 ] /P 153 0 R /Pg 134 0 R /S /P >> endobj %% Original object ID: 9971 0 1701 0 obj << /K [ 24 4217 0 R 26 ] /P 153 0 R /Pg 134 0 R /S /P >> endobj %% Original object ID: 9972 0 1702 0 obj << /K [ 27 4218 0 R 29 ] /P 153 0 R /Pg 134 0 R /S /P >> endobj %% Original object ID: 9973 0 1703 0 obj << /K [ 30 4219 0 R 32 ] /P 153 0 R /Pg 134 0 R /S /P >> endobj %% Original object ID: 9974 0 1704 0 obj << /K [ 33 4220 0 R 35 ] /P 153 0 R /Pg 134 0 R /S /P >> endobj %% Original object ID: 9975 0 1705 0 obj << /K [ 36 4221 0 R 38 ] /P 153 0 R /Pg 134 0 R /S /P >> endobj %% Original object ID: 9976 0 1706 0 obj << /K [ 39 4222 0 R 41 ] /P 153 0 R /Pg 134 0 R /S /P >> endobj %% Original object ID: 9977 0 1707 0 obj << /K [ 42 4223 0 R 44 ] /P 153 0 R /Pg 134 0 R /S /P >> endobj %% Original object ID: 9978 0 1708 0 obj << /K [ 45 4224 0 R 47 ] /P 153 0 R /Pg 134 0 R /S /P >> endobj %% Original object ID: 9979 0 1709 0 obj << /K [ 48 << /MCID 0 /Pg 135 0 R /Type /MCR >> << /MCID 0 /Pg 135 0 R /Type /MCR >> << /MCID 0 /Pg 135 0 R /Type /MCR >> ] /P 153 0 R /Pg 134 0 R /S /P >> endobj %% Original object ID: 9980 0 1710 0 obj << /K [ 3 4225 0 R 5 ] /P 153 0 R /Pg 135 0 R /S /P >> endobj %% Original object ID: 9981 0 1711 0 obj << /K [ 6 4226 0 R 8 ] /P 153 0 R /Pg 135 0 R /S /P >> endobj %% Original object ID: 9982 0 1712 0 obj << /K [ 9 4227 0 R 11 ] /P 153 0 R /Pg 135 0 R /S /P >> endobj %% Original object ID: 9983 0 1713 0 obj << /K [ 12 4228 0 R 14 ] /P 153 0 R /Pg 135 0 R /S /P >> endobj %% Original object ID: 9984 0 1714 0 obj << /K [ 15 4229 0 R 17 ] /P 153 0 R /Pg 135 0 R /S /P >> endobj %% Original object ID: 9985 0 1715 0 obj << /K [ 18 4230 0 R 20 ] /P 153 0 R /Pg 135 0 R /S /P >> endobj %% Original object ID: 9986 0 1716 0 obj << /K [ 21 4231 0 R 23 ] /P 153 0 R /Pg 135 0 R /S /P >> endobj %% Original object ID: 9987 0 1717 0 obj << /K [ 24 4232 0 R 26 ] /P 153 0 R /Pg 135 0 R /S /P >> endobj %% Original object ID: 9988 0 1718 0 obj << /K [ 27 4233 0 R 29 ] /P 153 0 R /Pg 135 0 R /S /P >> endobj %% 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153 0 R /Pg 136 0 R /S /P >> endobj %% Original object ID: 9998 0 1728 0 obj << /K [ 12 4242 0 R 14 ] /P 153 0 R /Pg 136 0 R /S /P >> endobj %% Original object ID: 9999 0 1729 0 obj << /K [ 15 4243 0 R 17 ] /P 153 0 R /Pg 136 0 R /S /P >> endobj %% Original object ID: 10000 0 1730 0 obj << /K [ 18 4244 0 R 20 ] /P 153 0 R /Pg 136 0 R /S /P >> endobj %% Original object ID: 10001 0 1731 0 obj << /K [ 21 4245 0 R 23 ] /P 153 0 R /Pg 136 0 R /S /P >> endobj %% Original object ID: 10002 0 1732 0 obj << /K [ 24 4246 0 R 26 ] /P 153 0 R /Pg 136 0 R /S /P >> endobj %% Original object ID: 10003 0 1733 0 obj << /K [ 27 4247 0 R 29 ] /P 153 0 R /Pg 136 0 R /S /P >> endobj %% Original object ID: 10004 0 1734 0 obj << /K [ 30 4248 0 R 32 ] /P 153 0 R /Pg 136 0 R /S /P >> endobj %% Original object ID: 10005 0 1735 0 obj << /K [ 33 4249 0 R 35 ] /P 153 0 R /Pg 136 0 R /S /P >> endobj %% Original object ID: 10006 0 1736 0 obj << /K [ 36 4250 0 R 38 ] /P 153 0 R /Pg 136 0 R /S /P >> endobj %% Original 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] /P 153 0 R /Pg 137 0 R /S /P >> endobj %% Original object ID: 10017 0 1747 0 obj << /K [ 24 4261 0 R 26 ] /P 153 0 R /Pg 137 0 R /S /P >> endobj %% Original object ID: 10018 0 1748 0 obj << /K [ 27 4262 0 R 29 ] /P 153 0 R /Pg 137 0 R /S /P >> endobj %% Original object ID: 10019 0 1749 0 obj << /K [ 30 4263 0 R 32 ] /P 153 0 R /Pg 137 0 R /S /P >> endobj %% Original object ID: 10020 0 1750 0 obj << /K [ 33 4264 0 R 35 ] /P 153 0 R /Pg 137 0 R /S /P >> endobj %% Original object ID: 10021 0 1751 0 obj << /K [ 36 4265 0 R 38 ] /P 153 0 R /Pg 137 0 R /S /P >> endobj %% Original object ID: 10022 0 1752 0 obj << /K [ 39 4266 0 R 41 ] /P 153 0 R /Pg 137 0 R /S /P >> endobj %% Original object ID: 10023 0 1753 0 obj << /K [ 42 4267 0 R 44 ] /P 153 0 R /Pg 137 0 R /S /P >> endobj %% Original object ID: 10024 0 1754 0 obj << /K [ 45 4268 0 R 47 ] /P 153 0 R /Pg 137 0 R /S /P >> endobj %% Original object ID: 10025 0 1755 0 obj << /K [ 0 4269 0 R 2 ] /P 153 0 R /Pg 138 0 R /S /P >> endobj %% 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0 R 44 ] /P 153 0 R /Pg 139 0 R /S /P >> endobj %% Original object ID: 10055 0 1785 0 obj << /K [ 45 4298 0 R 47 ] /P 153 0 R /Pg 139 0 R /S /P >> endobj %% Original object ID: 10056 0 1786 0 obj << /K [ 0 4299 0 R 2 ] /P 153 0 R /Pg 140 0 R /S /P >> endobj %% Original object ID: 10057 0 1787 0 obj << /K [ 3 4300 0 R 5 ] /P 153 0 R /Pg 140 0 R /S /P >> endobj %% Original object ID: 10058 0 1788 0 obj << /K [ 6 4301 0 R 8 ] /P 153 0 R /Pg 140 0 R /S /P >> endobj %% Original object ID: 10059 0 1789 0 obj << /K [ 9 4302 0 R 11 ] /P 153 0 R /Pg 140 0 R /S /P >> endobj %% Original object ID: 10060 0 1790 0 obj << /K [ 12 4303 0 R 14 ] /P 153 0 R /Pg 140 0 R /S /P >> endobj %% Original object ID: 10061 0 1791 0 obj << /K [ 15 4304 0 R 17 ] /P 153 0 R /Pg 140 0 R /S /P >> endobj %% Original object ID: 10062 0 1792 0 obj << /K [ 18 4305 0 R 20 ] /P 153 0 R /Pg 140 0 R /S /P >> endobj %% Original object ID: 10063 0 1793 0 obj << /K [ 21 4306 0 R 23 ] /P 153 0 R /Pg 140 0 R /S /P >> endobj %% 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142 0 R /S /P >> endobj %% Original object ID: 10092 0 1822 0 obj << /K [ 12 4332 0 R 14 ] /P 153 0 R /Pg 142 0 R /S /P >> endobj %% Original object ID: 10093 0 1823 0 obj << /K [ 15 4333 0 R 17 ] /P 153 0 R /Pg 142 0 R /S /P >> endobj %% Original object ID: 10094 0 1824 0 obj << /K [ 18 4334 0 R 20 ] /P 153 0 R /Pg 142 0 R /S /P >> endobj %% Original object ID: 10095 0 1825 0 obj << /K [ 21 4335 0 R 23 ] /P 153 0 R /Pg 142 0 R /S /P >> endobj %% Original object ID: 10096 0 1826 0 obj << /K [ 24 4336 0 R 26 ] /P 153 0 R /Pg 142 0 R /S /P >> endobj %% Original object ID: 10097 0 1827 0 obj << /K [ 27 4337 0 R 29 ] /P 153 0 R /Pg 142 0 R /S /P >> endobj %% Original object ID: 10098 0 1828 0 obj << /K [ 30 4338 0 R 32 ] /P 153 0 R /Pg 142 0 R /S /P >> endobj %% Original object ID: 10099 0 1829 0 obj << /K [ 33 4339 0 R 35 ] /P 153 0 R /Pg 142 0 R /S /P >> endobj %% Original object ID: 10100 0 1830 0 obj << /K [ 36 4340 0 R 38 ] /P 153 0 R /Pg 142 0 R /S /P >> endobj %% Original object ID: 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R 466 4799 0 R 467 4800 0 R 468 4801 0 R 469 4802 0 R 470 4803 0 R 471 4804 0 R 472 4805 0 R 474 4806 0 R 475 [ 1154 0 R null 3877 0 R null 3878 0 R 4807 0 R 3878 0 R null 3879 0 R 4808 0 R 3879 0 R null 3880 0 R 4809 0 R 3880 0 R null 3881 0 R 4810 0 R 3881 0 R null 3882 0 R 4811 0 R 3882 0 R null 3883 0 R 4812 0 R 3883 0 R null 3884 0 R 4813 0 R 3884 0 R null 3885 0 R 4814 0 R 3885 0 R null 3886 0 R 4815 0 R 3886 0 R null 3887 0 R 4816 0 R 3887 0 R null 3888 0 R 4817 0 R 3888 0 R null 3889 0 R 4818 0 R 3889 0 R null 3890 0 R 4819 0 R 3890 0 R null 3891 0 R 4820 0 R 3891 0 R null 3892 0 R 4821 0 R 3892 0 R null 3893 0 R 4822 0 R 3893 0 R null 3894 0 R 4823 0 R 3894 0 R null 3895 0 R 4824 0 R 3895 0 R null 3896 0 R 4825 0 R 3896 0 R null 3897 0 R 4826 0 R 3897 0 R null 3898 0 R 4827 0 R 3898 0 R null 3899 0 R 4828 0 R 3899 0 R null 3900 0 R 4829 0 R 3900 0 R null 3901 0 R 4830 0 R 3901 0 R null 3902 0 R 4831 0 R 3902 0 R null 3903 0 R 4832 0 R 3903 0 R null 3904 0 R 4833 0 R 3904 0 R null 3905 0 R 4834 0 R 3905 0 R null 3906 0 R 4835 0 R 3906 0 R null 3907 0 R 4836 0 R 3907 0 R null 3908 0 R 4837 0 R 3908 0 R null 3909 0 R 4838 0 R 3909 0 R null 3910 0 R 4839 0 R 3910 0 R null 3911 0 R 4840 0 R 3911 0 R null 3912 0 R 4841 0 R 3912 0 R null 3913 0 R 4842 0 R 3913 0 R null 3914 0 R 4843 0 R 3914 0 R null null null 3875 0 R null 3876 0 R null ] 477 [ 1157 0 R 1158 0 R 1159 0 R 1160 0 R 1161 0 R 1162 0 R ] 478 [ 1163 0 R 1164 0 R 1165 0 R 1166 0 R 1167 0 R 3915 0 R 1167 0 R 1168 0 R 1169 0 R 1170 0 R 1171 0 R 1172 0 R ] 479 [ 1173 0 R 1174 0 R 1175 0 R 1176 0 R 1177 0 R 1178 0 R 1179 0 R 1180 0 R ] 480 [ 1180 0 R 1181 0 R 1182 0 R 1183 0 R ] ] >> endobj %% Original object ID: 1808 0 1948 0 obj << /Limits [ 481 512 ] /Nums [ 481 [ 1183 0 R 1184 0 R 1185 0 R 1186 0 R 1187 0 R 1188 0 R ] 482 [ 1188 0 R 1189 0 R 1190 0 R 1191 0 R 1192 0 R ] 483 [ 1192 0 R null null 1193 0 R 1194 0 R 1195 0 R 1196 0 R 1197 0 R ] 484 [ 1197 0 R 1198 0 R 1199 0 R 1200 0 R 1201 0 R 1202 0 R 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] /P 1469 0 R /Pg 119 0 R /S /Link >> endobj %% Original object ID: 10380 0 4004 0 obj << /K [ 22 << /Obj 2744 0 R /Pg 119 0 R /Type /OBJR >> ] /P 1470 0 R /Pg 119 0 R /S /Link >> endobj %% Original object ID: 10382 0 4005 0 obj << /K [ 25 << /Obj 2745 0 R /Pg 119 0 R /Type /OBJR >> ] /P 1471 0 R /Pg 119 0 R /S /Link >> endobj %% Original object ID: 10384 0 4006 0 obj << /K [ 28 << /Obj 2746 0 R /Pg 119 0 R /Type /OBJR >> ] /P 1472 0 R /Pg 119 0 R /S /Link >> endobj %% Original object ID: 10386 0 4007 0 obj << /K [ 31 << /Obj 2747 0 R /Pg 119 0 R /Type /OBJR >> ] /P 1473 0 R /Pg 119 0 R /S /Link >> endobj %% Original object ID: 10388 0 4008 0 obj << /K [ 34 << /Obj 2748 0 R /Pg 119 0 R /Type /OBJR >> ] /P 1474 0 R /Pg 119 0 R /S /Link >> endobj %% Original object ID: 10390 0 4009 0 obj << /K [ 37 << /Obj 2749 0 R /Pg 119 0 R /Type /OBJR >> ] /P 1475 0 R /Pg 119 0 R /S /Link >> endobj %% Original object ID: 10392 0 4010 0 obj << /K [ 40 << /Obj 2750 0 R /Pg 119 0 R /Type /OBJR >> ] /P 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0 R /S /Link >> endobj %% Original object ID: 10422 0 4025 0 obj << /K [ 7 << /Obj 2767 0 R /Pg 121 0 R /Type /OBJR >> ] /P 1493 0 R /Pg 121 0 R /S /Link >> endobj %% Original object ID: 10424 0 4026 0 obj << /K [ 10 << /Obj 2768 0 R /Pg 121 0 R /Type /OBJR >> ] /P 1494 0 R /Pg 121 0 R /S /Link >> endobj %% Original object ID: 10426 0 4027 0 obj << /K [ 13 << /Obj 2769 0 R /Pg 121 0 R /Type /OBJR >> ] /P 1495 0 R /Pg 121 0 R /S /Link >> endobj %% Original object ID: 10428 0 4028 0 obj << /K [ 16 << /Obj 2770 0 R /Pg 121 0 R /Type /OBJR >> ] /P 1496 0 R /Pg 121 0 R /S /Link >> endobj %% Original object ID: 10430 0 4029 0 obj << /K [ 20 << /Obj 2771 0 R /Pg 121 0 R /Type /OBJR >> << /Obj 2772 0 R /Pg 121 0 R /Type /OBJR >> ] /P 1498 0 R /Pg 121 0 R /S /Link >> endobj %% Original object ID: 10433 0 4030 0 obj << /K [ 23 << /Obj 2773 0 R /Pg 121 0 R /Type /OBJR >> ] /P 1499 0 R /Pg 121 0 R /S /Link >> endobj %% Original object ID: 10435 0 4031 0 obj << /K [ 26 << /Obj 2774 0 R /Pg 121 0 R /Type /OBJR >> ] /P 1500 0 R /Pg 121 0 R /S /Link >> endobj %% Original object ID: 10437 0 4032 0 obj << /K [ 29 << /Obj 2775 0 R /Pg 121 0 R /Type /OBJR >> ] /P 1501 0 R /Pg 121 0 R /S /Link >> endobj %% Original object ID: 10439 0 4033 0 obj << /K [ 32 << /Obj 2776 0 R /Pg 121 0 R /Type /OBJR >> ] /P 1502 0 R /Pg 121 0 R /S /Link >> endobj %% Original object ID: 10441 0 4034 0 obj << /K [ 35 << /Obj 2777 0 R /Pg 121 0 R /Type /OBJR >> ] /P 1503 0 R /Pg 121 0 R /S /Link >> endobj %% Original object ID: 10443 0 4035 0 obj << /K [ 38 << /Obj 2778 0 R /Pg 121 0 R /Type /OBJR >> ] /P 1504 0 R /Pg 121 0 R /S /Link >> endobj %% Original object ID: 10445 0 4036 0 obj << /K [ 41 << /Obj 2779 0 R /Pg 121 0 R /Type /OBJR >> ] /P 1505 0 R /Pg 121 0 R /S /Link >> endobj %% Original object ID: 10447 0 4037 0 obj << /K [ 4 << /Obj 2781 0 R /Pg 122 0 R /Type /OBJR >> ] /P 1507 0 R /Pg 122 0 R /S /Link >> endobj %% Original object ID: 10449 0 4038 0 obj << /K [ 7 << /Obj 2782 0 R /Pg 122 0 R /Type /OBJR >> ] /P 1508 0 R /Pg 122 0 R /S /Link >> endobj %% Original object ID: 10451 0 4039 0 obj << /K [ 10 << /Obj 2783 0 R /Pg 122 0 R /Type /OBJR >> ] /P 1509 0 R /Pg 122 0 R /S /Link >> endobj %% Original object ID: 10453 0 4040 0 obj << /K [ 13 << /Obj 2784 0 R /Pg 122 0 R /Type /OBJR >> ] /P 1510 0 R /Pg 122 0 R /S /Link >> endobj %% Original object ID: 10455 0 4041 0 obj << /K [ 16 << /Obj 2785 0 R /Pg 122 0 R /Type /OBJR >> ] /P 1511 0 R /Pg 122 0 R /S /Link >> endobj %% Original object ID: 10457 0 4042 0 obj << /K [ 19 << /Obj 2786 0 R /Pg 122 0 R /Type /OBJR >> ] /P 1512 0 R /Pg 122 0 R /S /Link >> endobj %% Original object ID: 10459 0 4043 0 obj << /K [ 22 << /Obj 2787 0 R /Pg 122 0 R /Type /OBJR >> ] /P 1513 0 R /Pg 122 0 R /S /Link >> endobj %% Original object ID: 10461 0 4044 0 obj << /K [ 25 << /Obj 2788 0 R /Pg 122 0 R /Type /OBJR >> ] /P 1514 0 R /Pg 122 0 R /S /Link >> endobj %% Original object ID: 10463 0 4045 0 obj << /K [ 28 << /Obj 2789 0 R /Pg 122 0 R /Type /OBJR >> ] /P 1515 0 R /Pg 122 0 R /S /Link >> endobj %% Original object ID: 10465 0 4046 0 obj << /K [ 31 << /Obj 2790 0 R /Pg 122 0 R /Type /OBJR >> ] /P 1516 0 R /Pg 122 0 R /S /Link >> endobj %% Original object ID: 10467 0 4047 0 obj << /K [ 34 << /Obj 2791 0 R /Pg 122 0 R /Type /OBJR >> ] /P 1517 0 R /Pg 122 0 R /S /Link >> endobj %% Original object ID: 10469 0 4048 0 obj << /K [ 37 << /Obj 2792 0 R /Pg 122 0 R /Type /OBJR >> ] /P 1518 0 R /Pg 122 0 R /S /Link >> endobj %% Original object ID: 10471 0 4049 0 obj << /K [ 40 << /Obj 2793 0 R /Pg 122 0 R /Type /OBJR >> ] /P 1519 0 R /Pg 122 0 R /S /Link >> endobj %% Original object ID: 10473 0 4050 0 obj << /K [ 4 << /Obj 2795 0 R /Pg 123 0 R /Type /OBJR >> ] /P 1521 0 R /Pg 123 0 R /S /Link >> endobj %% Original object ID: 10475 0 4051 0 obj << /K [ 7 << /Obj 2796 0 R /Pg 123 0 R /Type /OBJR >> ] /P 1522 0 R /Pg 123 0 R /S /Link >> endobj %% Original object ID: 10477 0 4052 0 obj << /K [ 10 << /Obj 2797 0 R /Pg 123 0 R /Type /OBJR >> ] /P 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124 0 R /S /Link >> endobj %% Original object ID: 10507 0 4067 0 obj << /K [ 8 << /Obj 2812 0 R /Pg 124 0 R /Type /OBJR >> ] /P 1541 0 R /Pg 124 0 R /S /Link >> endobj %% Original object ID: 10509 0 4068 0 obj << /K [ 11 << /Obj 2813 0 R /Pg 124 0 R /Type /OBJR >> ] /P 1542 0 R /Pg 124 0 R /S /Link >> endobj %% Original object ID: 10511 0 4069 0 obj << /K [ 14 << /Obj 2814 0 R /Pg 124 0 R /Type /OBJR >> ] /P 1543 0 R /Pg 124 0 R /S /Link >> endobj %% Original object ID: 10513 0 4070 0 obj << /K [ 17 << /Obj 2815 0 R /Pg 124 0 R /Type /OBJR >> ] /P 1544 0 R /Pg 124 0 R /S /Link >> endobj %% Original object ID: 10515 0 4071 0 obj << /K [ 20 << /Obj 2816 0 R /Pg 124 0 R /Type /OBJR >> ] /P 1545 0 R /Pg 124 0 R /S /Link >> endobj %% Original object ID: 10517 0 4072 0 obj << /K [ 23 << /Obj 2817 0 R /Pg 124 0 R /Type /OBJR >> ] /P 1546 0 R /Pg 124 0 R /S /Link >> endobj %% Original object ID: 10519 0 4073 0 obj << /K [ 26 << /Obj 2818 0 R /Pg 124 0 R /Type /OBJR >> ] /P 1547 0 R /Pg 124 0 R /S /Link >> endobj %% Original object ID: 10521 0 4074 0 obj << /K [ 29 << /Obj 2819 0 R /Pg 124 0 R /Type /OBJR >> ] /P 1548 0 R /Pg 124 0 R /S /Link >> endobj %% Original object ID: 10523 0 4075 0 obj << /K [ 32 << /Obj 2820 0 R /Pg 124 0 R /Type /OBJR >> ] /P 1549 0 R /Pg 124 0 R /S /Link >> endobj %% Original object ID: 10525 0 4076 0 obj << /K [ 35 << /Obj 2821 0 R /Pg 124 0 R /Type /OBJR >> ] /P 1550 0 R /Pg 124 0 R /S /Link >> endobj %% Original object ID: 10527 0 4077 0 obj << /K [ 38 << /Obj 2822 0 R /Pg 124 0 R /Type /OBJR >> ] /P 1551 0 R /Pg 124 0 R /S /Link >> endobj %% Original object ID: 10529 0 4078 0 obj << /K [ 41 << /Obj 2823 0 R /Pg 124 0 R /Type /OBJR >> ] /P 1552 0 R /Pg 124 0 R /S /Link >> endobj %% Original object ID: 10531 0 4079 0 obj << /K [ 44 << /Obj 2824 0 R /Pg 124 0 R /Type /OBJR >> ] /P 1553 0 R /Pg 124 0 R /S /Link >> endobj %% Original object ID: 10533 0 4080 0 obj << /K [ 2 << /Obj 2825 0 R /Pg 125 0 R /Type /OBJR >> ] /P 1555 0 R /Pg 125 0 R /S /Link >> endobj %% Original object ID: 10535 0 4081 0 obj << /K [ 5 << /Obj 2826 0 R /Pg 125 0 R /Type /OBJR >> ] /P 1556 0 R /Pg 125 0 R /S /Link >> endobj %% Original object ID: 10537 0 4082 0 obj << /K [ 8 << /Obj 2827 0 R /Pg 125 0 R /Type /OBJR >> ] /P 1557 0 R /Pg 125 0 R /S /Link >> endobj %% Original object ID: 10539 0 4083 0 obj << /K [ 11 << /Obj 2828 0 R /Pg 125 0 R /Type /OBJR >> ] /P 1558 0 R /Pg 125 0 R /S /Link >> endobj %% Original object ID: 10541 0 4084 0 obj << /K [ 14 << /Obj 2829 0 R /Pg 125 0 R /Type /OBJR >> ] /P 1559 0 R /Pg 125 0 R /S /Link >> endobj %% Original object ID: 10543 0 4085 0 obj << /K [ 17 << /Obj 2830 0 R /Pg 125 0 R /Type /OBJR >> ] /P 1560 0 R /Pg 125 0 R /S /Link >> endobj %% Original object ID: 10545 0 4086 0 obj << /K [ 20 << /Obj 2831 0 R /Pg 125 0 R /Type /OBJR >> ] /P 1561 0 R /Pg 125 0 R /S /Link >> endobj %% Original object ID: 10547 0 4087 0 obj << /K [ 23 << /Obj 2832 0 R /Pg 125 0 R /Type /OBJR >> ] /P 1562 0 R /Pg 125 0 R /S /Link >> endobj %% Original object ID: 10549 0 4088 0 obj << /K [ 26 << /Obj 2833 0 R /Pg 125 0 R /Type /OBJR >> ] /P 1563 0 R /Pg 125 0 R /S /Link >> endobj %% Original object ID: 10551 0 4089 0 obj << /K [ 29 << /Obj 2834 0 R /Pg 125 0 R /Type /OBJR >> ] /P 1564 0 R /Pg 125 0 R /S /Link >> endobj %% Original object ID: 10553 0 4090 0 obj << /K [ 32 << /Obj 2835 0 R /Pg 125 0 R /Type /OBJR >> ] /P 1565 0 R /Pg 125 0 R /S /Link >> endobj %% Original object ID: 10555 0 4091 0 obj << /K [ 35 << /Obj 2836 0 R /Pg 125 0 R /Type /OBJR >> ] /P 1566 0 R /Pg 125 0 R /S /Link >> endobj %% Original object ID: 10557 0 4092 0 obj << /K [ 38 << /Obj 2837 0 R /Pg 125 0 R /Type /OBJR >> ] /P 1567 0 R /Pg 125 0 R /S /Link >> endobj %% Original object ID: 10559 0 4093 0 obj << /K [ 41 << /Obj 2838 0 R /Pg 125 0 R /Type /OBJR >> ] /P 1568 0 R /Pg 125 0 R /S /Link >> endobj %% Original object ID: 10561 0 4094 0 obj << /K [ 44 << /Obj 2839 0 R /Pg 125 0 R /Type /OBJR >> ] /P 1569 0 R /Pg 125 0 R /S /Link >> endobj %% Original object ID: 10563 0 4095 0 obj << /K [ 1 << /Obj 2840 0 R /Pg 126 0 R /Type /OBJR >> ] /P 1570 0 R /Pg 126 0 R /S /Link >> endobj %% Original object ID: 10565 0 4096 0 obj << /K [ 4 << /Obj 2841 0 R /Pg 126 0 R /Type /OBJR >> ] /P 1571 0 R /Pg 126 0 R /S /Link >> endobj %% Original object ID: 10567 0 4097 0 obj << /K [ 7 << /Obj 2842 0 R /Pg 126 0 R /Type /OBJR >> ] /P 1572 0 R /Pg 126 0 R /S /Link >> endobj %% Original object ID: 10569 0 4098 0 obj << /K [ 10 << /Obj 2843 0 R /Pg 126 0 R /Type /OBJR >> ] /P 1573 0 R /Pg 126 0 R /S /Link >> endobj %% Original object ID: 10571 0 4099 0 obj << /K [ 13 << /Obj 2844 0 R /Pg 126 0 R /Type /OBJR >> ] /P 1574 0 R /Pg 126 0 R /S /Link >> endobj %% Original object ID: 10573 0 4100 0 obj << /K [ 16 << /Obj 2845 0 R /Pg 126 0 R /Type /OBJR >> ] /P 1575 0 R /Pg 126 0 R /S /Link >> endobj %% Original object ID: 10575 0 4101 0 obj << /K [ 19 << /Obj 2846 0 R /Pg 126 0 R /Type /OBJR >> ] /P 1576 0 R /Pg 126 0 R /S /Link >> endobj %% Original object ID: 10577 0 4102 0 obj << /K [ 22 << /Obj 2847 0 R /Pg 126 0 R /Type /OBJR >> ] /P 1577 0 R /Pg 126 0 R /S /Link >> endobj %% Original object ID: 10579 0 4103 0 obj << /K [ 25 << /Obj 2848 0 R /Pg 126 0 R /Type /OBJR >> ] /P 1578 0 R /Pg 126 0 R /S /Link >> endobj %% Original object ID: 10581 0 4104 0 obj << /K [ 28 << /Obj 2849 0 R /Pg 126 0 R /Type /OBJR >> ] /P 1579 0 R /Pg 126 0 R /S /Link >> endobj %% Original object ID: 10583 0 4105 0 obj << /K [ 31 << /Obj 2850 0 R /Pg 126 0 R /Type /OBJR >> ] /P 1580 0 R /Pg 126 0 R /S /Link >> endobj %% Original object ID: 10585 0 4106 0 obj << /K [ 34 << /Obj 2851 0 R /Pg 126 0 R /Type /OBJR >> ] /P 1581 0 R /Pg 126 0 R /S /Link >> endobj %% Original object ID: 10587 0 4107 0 obj << /K [ 37 << /Obj 2852 0 R /Pg 126 0 R /Type /OBJR >> ] /P 1582 0 R /Pg 126 0 R /S /Link >> endobj %% Original object ID: 10589 0 4108 0 obj << /K [ 1 << /Obj 2853 0 R /Pg 127 0 R /Type /OBJR >> ] /P 1586 0 R /Pg 127 0 R /S /Link >> endobj %% Original object ID: 10591 0 4109 0 obj << /K [ 4 << /Obj 2854 0 R /Pg 127 0 R /Type /OBJR >> ] /P 1587 0 R /Pg 127 0 R /S /Link >> endobj %% Original object ID: 10593 0 4110 0 obj << /K [ 7 << /Obj 2855 0 R /Pg 127 0 R /Type /OBJR >> ] /P 1588 0 R /Pg 127 0 R /S /Link >> endobj %% Original object ID: 10595 0 4111 0 obj << /K [ 10 << /Obj 2856 0 R /Pg 127 0 R /Type /OBJR >> ] /P 1589 0 R /Pg 127 0 R /S /Link >> endobj %% Original object ID: 10597 0 4112 0 obj << /K [ 13 << /Obj 2857 0 R /Pg 127 0 R /Type /OBJR >> ] /P 1590 0 R /Pg 127 0 R /S /Link >> endobj %% Original object ID: 10599 0 4113 0 obj << /K [ 16 << /Obj 2858 0 R /Pg 127 0 R /Type /OBJR >> ] /P 1591 0 R /Pg 127 0 R /S /Link >> endobj %% Original object ID: 10601 0 4114 0 obj << /K [ 19 << /Obj 2859 0 R /Pg 127 0 R /Type /OBJR >> ] /P 1592 0 R /Pg 127 0 R /S /Link >> endobj %% Original object ID: 10603 0 4115 0 obj << /K [ 22 << /Obj 2860 0 R /Pg 127 0 R /Type /OBJR >> ] /P 1593 0 R /Pg 127 0 R /S /Link >> endobj %% Original object ID: 10605 0 4116 0 obj << /K [ 25 << /Obj 2861 0 R /Pg 127 0 R /Type /OBJR >> ] /P 1594 0 R /Pg 127 0 R /S /Link >> endobj %% Original object ID: 10607 0 4117 0 obj << /K [ 28 << /Obj 2862 0 R /Pg 127 0 R /Type /OBJR >> ] /P 1595 0 R /Pg 127 0 R /S /Link >> endobj %% Original object ID: 10609 0 4118 0 obj << /K [ 31 << /Obj 2863 0 R /Pg 127 0 R /Type /OBJR >> ] /P 1596 0 R /Pg 127 0 R /S /Link >> endobj %% Original object ID: 10611 0 4119 0 obj << /K [ 34 << /Obj 2864 0 R /Pg 127 0 R /Type /OBJR >> ] /P 1597 0 R /Pg 127 0 R /S /Link >> endobj %% Original object ID: 10613 0 4120 0 obj << /K [ 37 << /Obj 2865 0 R /Pg 127 0 R /Type /OBJR >> ] /P 1598 0 R /Pg 127 0 R /S /Link >> endobj %% Original object ID: 10615 0 4121 0 obj << /K [ 40 << /Obj 2866 0 R /Pg 127 0 R /Type /OBJR >> ] /P 1599 0 R /Pg 127 0 R /S /Link >> endobj %% Original object ID: 10617 0 4122 0 obj << /K [ 43 << /Obj 2867 0 R /Pg 127 0 R /Type /OBJR >> ] /P 1600 0 R /Pg 127 0 R /S /Link >> endobj %% Original object ID: 10619 0 4123 0 obj << /K [ 1 << /Obj 2868 0 R /Pg 128 0 R /Type /OBJR >> ] /P 1601 0 R /Pg 128 0 R /S /Link >> endobj %% Original object ID: 10621 0 4124 0 obj << /K [ 4 << /Obj 2869 0 R /Pg 128 0 R /Type /OBJR >> ] /P 1602 0 R /Pg 128 0 R /S /Link >> endobj %% Original object ID: 10623 0 4125 0 obj << /K [ 7 << /Obj 2870 0 R /Pg 128 0 R /Type /OBJR >> ] /P 1603 0 R /Pg 128 0 R /S /Link >> endobj %% Original object ID: 10625 0 4126 0 obj << /K [ 10 << /Obj 2871 0 R /Pg 128 0 R /Type /OBJR >> ] /P 1604 0 R /Pg 128 0 R /S /Link >> endobj %% Original object ID: 10627 0 4127 0 obj << /K [ 13 << /Obj 2872 0 R /Pg 128 0 R /Type /OBJR >> ] /P 1605 0 R /Pg 128 0 R /S /Link >> endobj %% Original object ID: 10629 0 4128 0 obj << /K [ 16 << /Obj 2873 0 R /Pg 128 0 R /Type /OBJR >> ] /P 1606 0 R /Pg 128 0 R /S /Link >> endobj %% Original object ID: 10631 0 4129 0 obj << /K [ 19 << /Obj 2874 0 R /Pg 128 0 R /Type /OBJR >> ] /P 1607 0 R /Pg 128 0 R /S /Link >> endobj %% Original object ID: 10633 0 4130 0 obj << /K [ 22 << /Obj 2875 0 R /Pg 128 0 R /Type /OBJR >> ] /P 1608 0 R /Pg 128 0 R /S /Link >> endobj %% Original object ID: 10635 0 4131 0 obj << /K [ 25 << /Obj 2876 0 R /Pg 128 0 R /Type /OBJR >> ] /P 1609 0 R /Pg 128 0 R /S /Link >> endobj %% Original object ID: 10637 0 4132 0 obj << /K [ 28 << /Obj 2877 0 R /Pg 128 0 R /Type /OBJR >> ] /P 1610 0 R /Pg 128 0 R /S /Link >> endobj %% Original object ID: 10639 0 4133 0 obj << /K [ 31 << /Obj 2878 0 R /Pg 128 0 R /Type /OBJR >> ] /P 1611 0 R /Pg 128 0 R /S /Link >> endobj %% Original object ID: 10641 0 4134 0 obj << /K [ 34 << /Obj 2879 0 R /Pg 128 0 R /Type /OBJR >> ] /P 1612 0 R /Pg 128 0 R /S /Link >> endobj %% Original object ID: 10643 0 4135 0 obj << /K [ 37 << /Obj 2880 0 R /Pg 128 0 R /Type /OBJR >> ] /P 1613 0 R /Pg 128 0 R /S /Link >> endobj %% Original object ID: 10645 0 4136 0 obj << /K [ 40 << /Obj 2881 0 R /Pg 128 0 R /Type /OBJR >> ] /P 1614 0 R /Pg 128 0 R /S /Link >> endobj %% Original object ID: 10647 0 4137 0 obj << /K [ 43 << /Obj 2882 0 R /Pg 128 0 R /Type /OBJR >> ] /P 1615 0 R /Pg 128 0 R /S /Link >> endobj %% Original object ID: 10649 0 4138 0 obj << /K [ 46 << /Obj 2883 0 R /Pg 128 0 R /Type /OBJR >> ] /P 1616 0 R /Pg 128 0 R /S /Link >> endobj %% Original object ID: 10651 0 4139 0 obj << /K [ 1 << /Obj 2884 0 R /Pg 129 0 R /Type /OBJR >> ] /P 1617 0 R /Pg 129 0 R /S /Link >> endobj %% Original object ID: 10653 0 4140 0 obj << /K [ 4 << /Obj 2885 0 R /Pg 129 0 R /Type /OBJR >> ] /P 1618 0 R /Pg 129 0 R /S /Link >> endobj %% Original object ID: 10655 0 4141 0 obj << /K [ 7 << /Obj 2886 0 R /Pg 129 0 R /Type /OBJR >> ] /P 1619 0 R /Pg 129 0 R /S /Link >> endobj %% Original object ID: 10657 0 4142 0 obj << /K [ 10 << /Obj 2887 0 R /Pg 129 0 R /Type /OBJR >> ] /P 1620 0 R /Pg 129 0 R /S /Link >> endobj %% Original object ID: 10659 0 4143 0 obj << /K [ 13 << /Obj 2888 0 R /Pg 129 0 R /Type /OBJR >> ] /P 1621 0 R /Pg 129 0 R /S /Link >> endobj %% Original object ID: 10661 0 4144 0 obj << /K [ 16 << /Obj 2889 0 R /Pg 129 0 R /Type /OBJR >> ] /P 1622 0 R /Pg 129 0 R /S /Link >> endobj %% Original object ID: 10663 0 4145 0 obj << /K [ 19 << /Obj 2890 0 R /Pg 129 0 R /Type /OBJR >> ] /P 1623 0 R /Pg 129 0 R /S /Link >> endobj %% Original object ID: 10665 0 4146 0 obj << /K [ 22 << /Obj 2891 0 R /Pg 129 0 R /Type /OBJR >> ] /P 1624 0 R /Pg 129 0 R /S /Link >> endobj %% Original object ID: 10667 0 4147 0 obj << /K [ 25 << /Obj 2892 0 R /Pg 129 0 R /Type /OBJR >> ] /P 1625 0 R /Pg 129 0 R /S /Link >> endobj %% Original object ID: 10669 0 4148 0 obj << /K [ 28 << /Obj 2893 0 R /Pg 129 0 R /Type /OBJR >> ] /P 1626 0 R /Pg 129 0 R /S /Link >> endobj %% Original object ID: 10671 0 4149 0 obj << /K [ 33 << /Obj 2894 0 R /Pg 129 0 R /Type /OBJR >> ] /P 1629 0 R /Pg 129 0 R /S /Link >> endobj %% Original object ID: 10673 0 4150 0 obj << /K [ 36 << /Obj 2895 0 R /Pg 129 0 R /Type /OBJR >> ] /P 1630 0 R /Pg 129 0 R /S /Link >> endobj %% Original object ID: 10675 0 4151 0 obj << /K [ 39 << /Obj 2896 0 R /Pg 129 0 R /Type /OBJR >> ] /P 1631 0 R /Pg 129 0 R /S /Link >> endobj %% Original object ID: 10677 0 4152 0 obj << /K [ 42 << /Obj 2897 0 R /Pg 129 0 R /Type /OBJR >> ] /P 1632 0 R /Pg 129 0 R /S /Link >> endobj %% Original object ID: 10679 0 4153 0 obj << /K [ 1 << /Obj 2898 0 R /Pg 130 0 R /Type /OBJR >> ] /P 1633 0 R /Pg 130 0 R /S /Link >> endobj %% Original object ID: 10681 0 4154 0 obj << /K [ 4 << /Obj 2899 0 R /Pg 130 0 R /Type /OBJR >> ] /P 1634 0 R /Pg 130 0 R /S /Link >> endobj %% Original object ID: 10683 0 4155 0 obj << /K [ 7 << /Obj 2900 0 R /Pg 130 0 R /Type /OBJR >> ] /P 1635 0 R /Pg 130 0 R /S /Link >> endobj %% Original object ID: 10685 0 4156 0 obj << /K [ 10 << /Obj 2901 0 R /Pg 130 0 R /Type /OBJR >> ] /P 1636 0 R /Pg 130 0 R /S /Link >> endobj %% Original object ID: 10687 0 4157 0 obj << /K [ 13 << /Obj 2902 0 R /Pg 130 0 R /Type /OBJR >> ] /P 1637 0 R /Pg 130 0 R /S /Link >> endobj %% Original object ID: 10689 0 4158 0 obj << /K [ 16 << /Obj 2903 0 R /Pg 130 0 R /Type /OBJR >> ] /P 1638 0 R /Pg 130 0 R /S /Link >> endobj %% Original object ID: 10691 0 4159 0 obj << /K [ 19 << /Obj 2904 0 R /Pg 130 0 R /Type /OBJR >> ] /P 1639 0 R /Pg 130 0 R /S /Link >> endobj %% Original object ID: 10693 0 4160 0 obj << /K [ 22 << /Obj 2905 0 R /Pg 130 0 R /Type /OBJR >> ] /P 1640 0 R /Pg 130 0 R /S /Link >> endobj %% Original object ID: 10695 0 4161 0 obj << /K [ 25 << /Obj 2906 0 R /Pg 130 0 R /Type /OBJR >> ] /P 1641 0 R /Pg 130 0 R /S /Link >> endobj %% Original object ID: 10697 0 4162 0 obj << /K [ 28 << /Obj 2907 0 R /Pg 130 0 R /Type /OBJR >> ] /P 1642 0 R /Pg 130 0 R /S /Link >> endobj %% Original object ID: 10699 0 4163 0 obj << /K [ 31 << /Obj 2908 0 R /Pg 130 0 R /Type /OBJR >> ] /P 1643 0 R /Pg 130 0 R /S /Link >> endobj %% Original object ID: 10701 0 4164 0 obj << /K [ 34 << /Obj 2909 0 R /Pg 130 0 R /Type /OBJR >> ] /P 1644 0 R /Pg 130 0 R /S /Link >> endobj %% Original object ID: 10703 0 4165 0 obj << /K [ 37 << /Obj 2910 0 R /Pg 130 0 R /Type /OBJR >> ] /P 1645 0 R /Pg 130 0 R /S /Link >> endobj %% Original object ID: 10705 0 4166 0 obj << /K [ 40 << /Obj 2911 0 R /Pg 130 0 R /Type /OBJR >> ] /P 1646 0 R /Pg 130 0 R /S /Link >> endobj %% Original object ID: 10707 0 4167 0 obj << /K [ 44 << /Obj 2912 0 R /Pg 130 0 R /Type /OBJR >> ] /P 1648 0 R /Pg 130 0 R /S /Link >> endobj %% Original object ID: 10709 0 4168 0 obj << /K [ 1 << /Obj 2913 0 R /Pg 131 0 R /Type /OBJR >> ] /P 1649 0 R /Pg 131 0 R /S /Link >> endobj %% Original object ID: 10711 0 4169 0 obj << /K [ 4 << /Obj 2914 0 R /Pg 131 0 R /Type /OBJR >> ] /P 1650 0 R /Pg 131 0 R /S /Link >> endobj %% Original object ID: 10713 0 4170 0 obj << /K [ 7 << /Obj 2915 0 R /Pg 131 0 R /Type /OBJR >> ] /P 1651 0 R /Pg 131 0 R /S /Link >> endobj %% Original object ID: 10715 0 4171 0 obj << /K [ 10 << /Obj 2916 0 R /Pg 131 0 R /Type /OBJR >> ] /P 1652 0 R /Pg 131 0 R /S /Link >> endobj %% Original object ID: 10717 0 4172 0 obj << /K [ 13 << /Obj 2917 0 R /Pg 131 0 R /Type /OBJR >> ] /P 1653 0 R /Pg 131 0 R /S /Link >> endobj %% Original object ID: 10719 0 4173 0 obj << /K [ 16 << /Obj 2918 0 R /Pg 131 0 R /Type /OBJR >> ] /P 1654 0 R /Pg 131 0 R /S /Link >> endobj %% Original object ID: 10721 0 4174 0 obj << /K [ 19 << /Obj 2919 0 R /Pg 131 0 R /Type /OBJR >> ] /P 1655 0 R /Pg 131 0 R /S /Link >> endobj %% Original object ID: 10723 0 4175 0 obj << /K [ 22 << /Obj 2920 0 R /Pg 131 0 R /Type /OBJR >> ] /P 1656 0 R /Pg 131 0 R /S /Link >> endobj %% Original object ID: 10725 0 4176 0 obj << /K [ 25 << /Obj 2921 0 R /Pg 131 0 R /Type /OBJR >> ] /P 1657 0 R /Pg 131 0 R /S /Link >> endobj %% Original object ID: 10727 0 4177 0 obj << /K [ 28 << /Obj 2922 0 R /Pg 131 0 R /Type /OBJR >> ] /P 1658 0 R /Pg 131 0 R /S /Link >> endobj %% Original object ID: 10729 0 4178 0 obj << /K [ 31 << /Obj 2923 0 R /Pg 131 0 R /Type /OBJR >> ] /P 1659 0 R /Pg 131 0 R /S /Link >> endobj %% Original object ID: 10731 0 4179 0 obj << /K [ 34 << /Obj 2924 0 R /Pg 131 0 R /Type /OBJR >> ] /P 1660 0 R /Pg 131 0 R /S /Link >> endobj %% Original object ID: 10733 0 4180 0 obj << /K [ 37 << /Obj 2925 0 R /Pg 131 0 R /Type /OBJR >> ] /P 1661 0 R /Pg 131 0 R /S /Link >> endobj %% Original object ID: 10735 0 4181 0 obj << /K [ 40 << /Obj 2926 0 R /Pg 131 0 R /Type /OBJR >> ] /P 1662 0 R /Pg 131 0 R /S /Link >> endobj %% Original object ID: 10737 0 4182 0 obj << /K [ 4 << /Obj 2928 0 R /Pg 132 0 R /Type /OBJR >> ] /P 1664 0 R /Pg 132 0 R /S /Link >> endobj %% Original object ID: 10739 0 4183 0 obj << /K [ 7 << /Obj 2929 0 R /Pg 132 0 R /Type /OBJR >> ] /P 1665 0 R /Pg 132 0 R /S /Link >> endobj %% Original object ID: 10741 0 4184 0 obj << /K [ 10 << /Obj 2930 0 R /Pg 132 0 R /Type /OBJR >> ] /P 1666 0 R /Pg 132 0 R /S /Link >> endobj %% Original object ID: 10743 0 4185 0 obj << /K [ 13 << /Obj 2931 0 R /Pg 132 0 R /Type /OBJR >> ] /P 1667 0 R /Pg 132 0 R /S /Link >> endobj %% Original object ID: 10745 0 4186 0 obj << /K [ 16 << /Obj 2932 0 R /Pg 132 0 R /Type /OBJR >> ] /P 1668 0 R /Pg 132 0 R /S /Link >> endobj %% Original object ID: 10747 0 4187 0 obj << /K [ 19 << /Obj 2933 0 R /Pg 132 0 R /Type /OBJR >> ] /P 1669 0 R /Pg 132 0 R /S /Link >> endobj %% Original object ID: 10749 0 4188 0 obj << /K [ 22 << /Obj 2934 0 R /Pg 132 0 R /Type /OBJR >> ] /P 1670 0 R /Pg 132 0 R /S /Link >> endobj %% Original object ID: 10751 0 4189 0 obj << /K [ 25 << /Obj 2935 0 R /Pg 132 0 R /Type /OBJR >> ] /P 1671 0 R /Pg 132 0 R /S /Link >> endobj %% Original object ID: 10753 0 4190 0 obj << /K [ 28 << /Obj 2936 0 R /Pg 132 0 R /Type /OBJR >> ] /P 1672 0 R /Pg 132 0 R /S /Link >> endobj %% Original object ID: 10755 0 4191 0 obj << /K [ 31 << /Obj 2937 0 R /Pg 132 0 R /Type /OBJR >> ] /P 1673 0 R /Pg 132 0 R /S /Link >> endobj %% Original object ID: 10757 0 4192 0 obj << /K [ 34 << /Obj 2938 0 R /Pg 132 0 R /Type /OBJR >> ] /P 1674 0 R /Pg 132 0 R /S /Link >> endobj %% Original object ID: 10759 0 4193 0 obj << /K [ 37 << /Obj 2939 0 R /Pg 132 0 R /Type /OBJR >> ] /P 1675 0 R /Pg 132 0 R /S /Link >> endobj %% Original object ID: 10761 0 4194 0 obj << /K [ 40 << /Obj 2940 0 R /Pg 132 0 R /Type /OBJR >> ] /P 1676 0 R /Pg 132 0 R /S /Link >> endobj %% Original object ID: 10763 0 4195 0 obj << /K [ 43 << /Obj 2941 0 R /Pg 132 0 R /Type /OBJR >> ] /P 1677 0 R /Pg 132 0 R /S /Link >> endobj %% Original object ID: 10765 0 4196 0 obj << /K [ 4 << /Obj 2943 0 R /Pg 133 0 R /Type /OBJR >> ] /P 1679 0 R /Pg 133 0 R /S /Link >> endobj %% Original object ID: 10767 0 4197 0 obj << /K [ 7 << /Obj 2944 0 R /Pg 133 0 R /Type /OBJR >> ] /P 1680 0 R /Pg 133 0 R /S /Link >> endobj %% Original object ID: 10769 0 4198 0 obj << /K [ 10 << /Obj 2945 0 R /Pg 133 0 R /Type /OBJR >> ] /P 1681 0 R /Pg 133 0 R /S /Link >> endobj %% Original object ID: 10771 0 4199 0 obj << /K [ 13 << /Obj 2946 0 R /Pg 133 0 R /Type /OBJR >> ] /P 1682 0 R /Pg 133 0 R /S /Link >> endobj %% Original object ID: 10773 0 4200 0 obj << /K [ 16 << /Obj 2947 0 R /Pg 133 0 R /Type /OBJR >> ] /P 1683 0 R /Pg 133 0 R /S /Link >> endobj %% Original object ID: 10775 0 4201 0 obj << /K [ 19 << /Obj 2948 0 R /Pg 133 0 R /Type /OBJR >> ] /P 1684 0 R /Pg 133 0 R /S /Link >> endobj %% Original object ID: 10777 0 4202 0 obj << /K [ 22 << /Obj 2949 0 R /Pg 133 0 R /Type /OBJR >> ] /P 1685 0 R /Pg 133 0 R /S /Link >> endobj %% Original object ID: 10779 0 4203 0 obj << /K [ 25 << /Obj 2950 0 R /Pg 133 0 R /Type /OBJR >> ] /P 1686 0 R /Pg 133 0 R /S /Link >> endobj %% Original object ID: 10781 0 4204 0 obj << /K [ 28 << /Obj 2951 0 R /Pg 133 0 R /Type /OBJR >> ] /P 1687 0 R /Pg 133 0 R /S /Link >> endobj %% Original object ID: 10783 0 4205 0 obj << /K [ 31 << /Obj 2952 0 R /Pg 133 0 R /Type /OBJR >> ] /P 1688 0 R /Pg 133 0 R /S /Link >> endobj %% Original object ID: 10785 0 4206 0 obj << /K [ 34 << /Obj 2953 0 R /Pg 133 0 R /Type /OBJR >> ] /P 1689 0 R /Pg 133 0 R /S /Link >> endobj %% Original object ID: 10787 0 4207 0 obj << /K [ 37 << /Obj 2954 0 R /Pg 133 0 R /Type /OBJR >> ] /P 1690 0 R /Pg 133 0 R /S /Link >> endobj %% Original object ID: 10789 0 4208 0 obj << /K [ 40 << /Obj 2955 0 R /Pg 133 0 R /Type /OBJR >> ] /P 1691 0 R /Pg 133 0 R /S /Link >> endobj %% Original object ID: 10791 0 4209 0 obj << /K [ 43 << /Obj 2956 0 R /Pg 133 0 R /Type /OBJR >> ] /P 1692 0 R /Pg 133 0 R /S /Link >> endobj %% Original object ID: 10793 0 4210 0 obj << /K [ 4 << /Obj 2958 0 R /Pg 134 0 R /Type /OBJR >> ] /P 1694 0 R /Pg 134 0 R /S /Link >> endobj %% Original object ID: 10795 0 4211 0 obj << /K [ 7 << /Obj 2959 0 R /Pg 134 0 R /Type /OBJR >> ] /P 1695 0 R /Pg 134 0 R /S /Link >> endobj %% Original object ID: 10797 0 4212 0 obj << /K [ 10 << /Obj 2960 0 R /Pg 134 0 R /Type /OBJR >> ] /P 1696 0 R /Pg 134 0 R /S /Link >> endobj %% Original object ID: 10799 0 4213 0 obj << /K [ 13 << /Obj 2961 0 R /Pg 134 0 R /Type /OBJR >> ] /P 1697 0 R /Pg 134 0 R /S /Link >> endobj %% Original object ID: 10801 0 4214 0 obj << /K [ 16 << /Obj 2962 0 R /Pg 134 0 R /Type /OBJR >> ] /P 1698 0 R /Pg 134 0 R /S /Link >> endobj %% Original object ID: 10803 0 4215 0 obj << /K [ 19 << /Obj 2963 0 R /Pg 134 0 R /Type /OBJR >> ] /P 1699 0 R /Pg 134 0 R /S /Link >> endobj %% Original object ID: 10805 0 4216 0 obj << /K [ 22 << /Obj 2964 0 R /Pg 134 0 R /Type /OBJR >> ] /P 1700 0 R /Pg 134 0 R /S /Link >> endobj %% Original object ID: 10807 0 4217 0 obj << /K [ 25 << /Obj 2965 0 R /Pg 134 0 R /Type /OBJR >> ] /P 1701 0 R /Pg 134 0 R /S /Link >> endobj %% Original object ID: 10809 0 4218 0 obj << /K [ 28 << /Obj 2966 0 R /Pg 134 0 R /Type /OBJR >> ] /P 1702 0 R /Pg 134 0 R /S /Link >> endobj %% Original object ID: 10811 0 4219 0 obj << /K [ 31 << /Obj 2967 0 R /Pg 134 0 R /Type /OBJR >> ] /P 1703 0 R /Pg 134 0 R /S /Link >> endobj %% Original object ID: 10813 0 4220 0 obj << /K [ 34 << /Obj 2968 0 R /Pg 134 0 R /Type /OBJR >> ] /P 1704 0 R /Pg 134 0 R /S /Link >> endobj %% Original object ID: 10815 0 4221 0 obj << /K [ 37 << /Obj 2969 0 R /Pg 134 0 R /Type /OBJR >> ] /P 1705 0 R /Pg 134 0 R /S /Link >> endobj %% Original object ID: 10817 0 4222 0 obj << /K [ 40 << /Obj 2970 0 R /Pg 134 0 R /Type /OBJR >> ] /P 1706 0 R /Pg 134 0 R /S /Link >> endobj %% Original object ID: 10819 0 4223 0 obj << /K [ 43 << /Obj 2971 0 R /Pg 134 0 R /Type /OBJR >> ] /P 1707 0 R /Pg 134 0 R /S /Link >> endobj %% Original object ID: 10821 0 4224 0 obj << /K [ 46 << /Obj 2972 0 R /Pg 134 0 R /Type /OBJR >> ] /P 1708 0 R /Pg 134 0 R /S /Link >> endobj %% Original object ID: 10823 0 4225 0 obj << /K [ 4 << /Obj 2974 0 R /Pg 135 0 R /Type /OBJR >> ] /P 1710 0 R /Pg 135 0 R /S /Link >> endobj %% Original object ID: 10825 0 4226 0 obj << /K [ 7 << /Obj 2975 0 R /Pg 135 0 R /Type /OBJR >> ] /P 1711 0 R /Pg 135 0 R /S /Link >> endobj %% Original object ID: 10827 0 4227 0 obj << /K [ 10 << /Obj 2976 0 R /Pg 135 0 R /Type /OBJR >> ] /P 1712 0 R /Pg 135 0 R /S /Link >> endobj %% Original object ID: 10829 0 4228 0 obj << /K [ 13 << /Obj 2977 0 R /Pg 135 0 R /Type /OBJR >> ] /P 1713 0 R /Pg 135 0 R /S /Link >> endobj %% Original object ID: 10831 0 4229 0 obj << /K [ 16 << /Obj 2978 0 R /Pg 135 0 R /Type /OBJR >> ] /P 1714 0 R /Pg 135 0 R /S /Link >> endobj %% Original object ID: 10833 0 4230 0 obj << /K [ 19 << /Obj 2979 0 R /Pg 135 0 R /Type /OBJR >> ] /P 1715 0 R /Pg 135 0 R /S /Link >> endobj %% Original object ID: 10835 0 4231 0 obj << /K [ 22 << /Obj 2980 0 R /Pg 135 0 R /Type /OBJR >> ] /P 1716 0 R /Pg 135 0 R /S /Link >> endobj %% Original object ID: 10837 0 4232 0 obj << /K [ 25 << /Obj 2981 0 R /Pg 135 0 R /Type /OBJR >> ] /P 1717 0 R /Pg 135 0 R /S /Link >> endobj %% Original object ID: 10839 0 4233 0 obj << /K [ 28 << /Obj 2982 0 R /Pg 135 0 R /Type /OBJR >> ] /P 1718 0 R /Pg 135 0 R /S /Link >> endobj %% Original object ID: 10841 0 4234 0 obj << /K [ 31 << /Obj 2983 0 R /Pg 135 0 R /Type /OBJR >> ] /P 1719 0 R /Pg 135 0 R /S /Link >> endobj %% Original object ID: 10843 0 4235 0 obj << /K [ 34 << /Obj 2984 0 R /Pg 135 0 R /Type /OBJR >> ] /P 1720 0 R /Pg 135 0 R /S /Link >> endobj %% Original object ID: 10845 0 4236 0 obj << /K [ 37 << /Obj 2985 0 R /Pg 135 0 R /Type /OBJR >> ] /P 1721 0 R /Pg 135 0 R /S /Link >> endobj %% Original object ID: 10847 0 4237 0 obj << /K [ 40 << /Obj 2986 0 R /Pg 135 0 R /Type /OBJR >> ] /P 1722 0 R /Pg 135 0 R /S /Link >> endobj %% Original object ID: 10849 0 4238 0 obj << /K [ 43 << /Obj 2987 0 R /Pg 135 0 R /Type /OBJR >> ] /P 1723 0 R /Pg 135 0 R /S /Link >> endobj %% Original object ID: 10851 0 4239 0 obj << /K [ 4 << /Obj 2989 0 R /Pg 136 0 R /Type /OBJR >> ] /P 1725 0 R /Pg 136 0 R /S /Link >> endobj %% Original object ID: 10853 0 4240 0 obj << /K [ 7 << /Obj 2990 0 R /Pg 136 0 R /Type /OBJR >> ] /P 1726 0 R /Pg 136 0 R /S /Link >> endobj %% Original object ID: 10855 0 4241 0 obj << /K [ 10 << /Obj 2991 0 R /Pg 136 0 R /Type /OBJR >> ] /P 1727 0 R /Pg 136 0 R /S /Link >> endobj %% Original object ID: 10857 0 4242 0 obj << /K [ 13 << /Obj 2992 0 R /Pg 136 0 R /Type /OBJR >> ] /P 1728 0 R /Pg 136 0 R /S /Link >> endobj %% Original object ID: 10859 0 4243 0 obj << /K [ 16 << /Obj 2993 0 R /Pg 136 0 R /Type /OBJR >> ] /P 1729 0 R /Pg 136 0 R /S /Link >> endobj %% Original object ID: 10861 0 4244 0 obj << /K [ 19 << /Obj 2994 0 R /Pg 136 0 R /Type /OBJR >> ] /P 1730 0 R /Pg 136 0 R /S /Link >> endobj %% Original object ID: 10863 0 4245 0 obj << /K [ 22 << /Obj 2995 0 R /Pg 136 0 R /Type /OBJR >> ] /P 1731 0 R /Pg 136 0 R /S /Link >> endobj %% Original object ID: 10865 0 4246 0 obj << /K [ 25 << /Obj 2996 0 R /Pg 136 0 R /Type /OBJR >> ] /P 1732 0 R /Pg 136 0 R /S /Link >> endobj %% Original object ID: 10867 0 4247 0 obj << /K [ 28 << /Obj 2997 0 R /Pg 136 0 R /Type /OBJR >> ] /P 1733 0 R /Pg 136 0 R /S /Link >> endobj %% Original object ID: 10869 0 4248 0 obj << /K [ 31 << /Obj 2998 0 R /Pg 136 0 R /Type /OBJR >> ] /P 1734 0 R /Pg 136 0 R /S /Link >> endobj %% Original object ID: 10871 0 4249 0 obj << /K [ 34 << /Obj 2999 0 R /Pg 136 0 R /Type /OBJR >> ] /P 1735 0 R /Pg 136 0 R /S /Link >> endobj %% Original object ID: 10873 0 4250 0 obj << /K [ 37 << /Obj 3000 0 R /Pg 136 0 R /Type /OBJR >> ] /P 1736 0 R /Pg 136 0 R /S /Link >> endobj %% Original object ID: 10875 0 4251 0 obj << /K [ 40 << /Obj 3001 0 R /Pg 136 0 R /Type /OBJR >> ] /P 1737 0 R /Pg 136 0 R /S /Link >> endobj %% Original object ID: 10877 0 4252 0 obj << /K [ 43 << /Obj 3002 0 R /Pg 136 0 R /Type /OBJR >> ] /P 1738 0 R /Pg 136 0 R /S /Link >> endobj %% Original object ID: 10879 0 4253 0 obj << /K [ 1 << /Obj 3003 0 R /Pg 137 0 R /Type /OBJR >> ] /P 1739 0 R /Pg 137 0 R /S /Link >> endobj %% Original object ID: 10881 0 4254 0 obj << /K [ 4 << /Obj 3004 0 R /Pg 137 0 R /Type /OBJR >> ] /P 1740 0 R /Pg 137 0 R /S /Link >> endobj %% Original object ID: 10883 0 4255 0 obj << /K [ 7 << /Obj 3005 0 R /Pg 137 0 R /Type /OBJR >> ] /P 1741 0 R /Pg 137 0 R /S /Link >> endobj %% Original object ID: 10885 0 4256 0 obj << /K [ 10 << /Obj 3006 0 R /Pg 137 0 R /Type /OBJR >> ] /P 1742 0 R /Pg 137 0 R /S /Link >> endobj %% Original object ID: 10887 0 4257 0 obj << /K [ 13 << /Obj 3007 0 R /Pg 137 0 R /Type /OBJR >> ] /P 1743 0 R /Pg 137 0 R /S /Link >> endobj %% Original object ID: 10889 0 4258 0 obj << /K [ 16 << /Obj 3008 0 R /Pg 137 0 R /Type /OBJR >> ] /P 1744 0 R /Pg 137 0 R /S /Link >> endobj %% Original object ID: 10891 0 4259 0 obj << /K [ 19 << /Obj 3009 0 R /Pg 137 0 R /Type /OBJR >> ] /P 1745 0 R /Pg 137 0 R /S /Link >> endobj %% Original object ID: 10893 0 4260 0 obj << /K [ 22 << /Obj 3010 0 R /Pg 137 0 R /Type /OBJR >> ] /P 1746 0 R /Pg 137 0 R /S /Link >> endobj %% Original object ID: 10895 0 4261 0 obj << /K [ 25 << /Obj 3011 0 R /Pg 137 0 R /Type /OBJR >> ] /P 1747 0 R /Pg 137 0 R /S /Link >> endobj %% Original object ID: 10897 0 4262 0 obj << /K [ 28 << /Obj 3012 0 R /Pg 137 0 R /Type /OBJR >> ] /P 1748 0 R /Pg 137 0 R /S /Link >> endobj %% Original object ID: 10899 0 4263 0 obj << /K [ 31 << /Obj 3013 0 R /Pg 137 0 R /Type /OBJR >> ] /P 1749 0 R /Pg 137 0 R /S /Link >> endobj %% Original object ID: 10901 0 4264 0 obj << /K [ 34 << /Obj 3014 0 R /Pg 137 0 R /Type /OBJR >> ] /P 1750 0 R /Pg 137 0 R /S /Link >> endobj %% Original object ID: 10903 0 4265 0 obj << /K [ 37 << /Obj 3015 0 R /Pg 137 0 R /Type /OBJR >> ] /P 1751 0 R /Pg 137 0 R /S /Link >> endobj %% Original object ID: 10905 0 4266 0 obj << /K [ 40 << /Obj 3016 0 R /Pg 137 0 R /Type /OBJR >> ] /P 1752 0 R /Pg 137 0 R /S /Link >> endobj %% Original object ID: 10907 0 4267 0 obj << /K [ 43 << /Obj 3017 0 R /Pg 137 0 R /Type /OBJR >> ] /P 1753 0 R /Pg 137 0 R /S /Link >> endobj %% Original object ID: 10909 0 4268 0 obj << /K [ 46 << /Obj 3018 0 R /Pg 137 0 R /Type /OBJR >> ] /P 1754 0 R /Pg 137 0 R /S /Link >> endobj %% Original object ID: 10911 0 4269 0 obj << /K [ 1 << /Obj 3019 0 R /Pg 138 0 R /Type /OBJR >> ] /P 1755 0 R /Pg 138 0 R /S /Link >> endobj %% Original object ID: 10913 0 4270 0 obj << /K [ 4 << /Obj 3020 0 R /Pg 138 0 R /Type /OBJR >> ] /P 1756 0 R /Pg 138 0 R /S /Link >> endobj %% Original object ID: 10915 0 4271 0 obj << /K [ 7 << /Obj 3021 0 R /Pg 138 0 R /Type /OBJR >> ] /P 1757 0 R /Pg 138 0 R /S /Link >> endobj %% Original object ID: 10917 0 4272 0 obj << /K [ 11 << /Obj 3022 0 R /Pg 138 0 R /Type /OBJR >> ] /P 1759 0 R /Pg 138 0 R /S /Link >> endobj %% Original object ID: 10919 0 4273 0 obj << /K [ 14 << /Obj 3023 0 R /Pg 138 0 R /Type /OBJR >> ] /P 1760 0 R /Pg 138 0 R /S /Link >> endobj %% Original object ID: 10921 0 4274 0 obj << /K [ 17 << /Obj 3024 0 R /Pg 138 0 R /Type /OBJR >> ] /P 1761 0 R /Pg 138 0 R /S /Link >> endobj %% Original object ID: 10923 0 4275 0 obj << /K [ 20 << /Obj 3025 0 R /Pg 138 0 R /Type /OBJR >> ] /P 1762 0 R /Pg 138 0 R /S /Link >> endobj %% Original object ID: 10925 0 4276 0 obj << /K [ 23 << /Obj 3026 0 R /Pg 138 0 R /Type /OBJR >> ] /P 1763 0 R /Pg 138 0 R /S /Link >> endobj %% Original object ID: 10927 0 4277 0 obj << /K [ 26 << /Obj 3027 0 R /Pg 138 0 R /Type /OBJR >> ] /P 1764 0 R /Pg 138 0 R /S /Link >> endobj %% Original object ID: 10929 0 4278 0 obj << /K [ 29 << /Obj 3028 0 R /Pg 138 0 R /Type /OBJR >> ] /P 1765 0 R /Pg 138 0 R /S /Link >> endobj %% Original object ID: 10931 0 4279 0 obj << /K [ 32 << /Obj 3029 0 R /Pg 138 0 R /Type /OBJR >> ] /P 1766 0 R /Pg 138 0 R /S /Link >> endobj %% Original object ID: 10933 0 4280 0 obj << /K [ 35 << /Obj 3030 0 R /Pg 138 0 R /Type /OBJR >> ] /P 1767 0 R /Pg 138 0 R /S /Link >> endobj %% Original object ID: 10935 0 4281 0 obj << /K [ 38 << /Obj 3031 0 R /Pg 138 0 R /Type /OBJR >> ] /P 1768 0 R /Pg 138 0 R /S /Link >> endobj %% Original object ID: 10937 0 4282 0 obj << /K [ 41 << /Obj 3032 0 R /Pg 138 0 R /Type /OBJR >> ] /P 1769 0 R /Pg 138 0 R /S /Link >> endobj %% Original object ID: 10939 0 4283 0 obj << /K [ 1 << /Obj 3033 0 R /Pg 139 0 R /Type /OBJR >> ] /P 1770 0 R /Pg 139 0 R /S /Link >> endobj %% Original object ID: 10941 0 4284 0 obj << /K [ 4 << /Obj 3034 0 R /Pg 139 0 R /Type /OBJR >> ] /P 1771 0 R /Pg 139 0 R /S /Link >> endobj %% Original object ID: 10943 0 4285 0 obj << /K [ 7 << /Obj 3035 0 R /Pg 139 0 R /Type /OBJR >> ] /P 1772 0 R /Pg 139 0 R /S /Link >> endobj %% Original object ID: 10945 0 4286 0 obj << /K [ 10 << /Obj 3036 0 R /Pg 139 0 R /Type /OBJR >> ] /P 1773 0 R /Pg 139 0 R /S /Link >> endobj %% Original object ID: 10947 0 4287 0 obj << /K [ 13 << /Obj 3037 0 R /Pg 139 0 R /Type /OBJR >> ] /P 1774 0 R /Pg 139 0 R /S /Link >> endobj %% Original object ID: 10949 0 4288 0 obj << /K [ 16 << /Obj 3038 0 R /Pg 139 0 R /Type /OBJR >> ] /P 1775 0 R /Pg 139 0 R /S /Link >> endobj %% Original object ID: 10951 0 4289 0 obj << /K [ 19 << /Obj 3039 0 R /Pg 139 0 R /Type /OBJR >> ] /P 1776 0 R /Pg 139 0 R /S /Link >> endobj %% Original object ID: 10953 0 4290 0 obj << /K [ 22 << /Obj 3040 0 R /Pg 139 0 R /Type /OBJR >> ] /P 1777 0 R /Pg 139 0 R /S /Link >> endobj %% Original object ID: 10955 0 4291 0 obj << /K [ 25 << /Obj 3041 0 R /Pg 139 0 R /Type /OBJR >> ] /P 1778 0 R /Pg 139 0 R /S /Link >> endobj %% Original object ID: 10957 0 4292 0 obj << /K [ 28 << /Obj 3042 0 R /Pg 139 0 R /Type /OBJR >> ] /P 1779 0 R /Pg 139 0 R /S /Link >> endobj %% Original object ID: 10959 0 4293 0 obj << /K [ 31 << /Obj 3043 0 R /Pg 139 0 R /Type /OBJR >> ] /P 1780 0 R /Pg 139 0 R /S /Link >> endobj %% Original object ID: 10961 0 4294 0 obj << /K [ 34 << /Obj 3044 0 R /Pg 139 0 R /Type /OBJR >> ] /P 1781 0 R /Pg 139 0 R /S /Link >> endobj %% Original object ID: 10963 0 4295 0 obj << /K [ 37 << /Obj 3045 0 R /Pg 139 0 R /Type /OBJR >> ] /P 1782 0 R /Pg 139 0 R /S /Link >> endobj %% Original object ID: 10965 0 4296 0 obj << /K [ 40 << /Obj 3046 0 R /Pg 139 0 R /Type /OBJR >> ] /P 1783 0 R /Pg 139 0 R /S /Link >> endobj %% Original object ID: 10967 0 4297 0 obj << /K [ 43 << /Obj 3047 0 R /Pg 139 0 R /Type /OBJR >> ] /P 1784 0 R /Pg 139 0 R /S /Link >> endobj %% Original object ID: 10969 0 4298 0 obj << /K [ 46 << /Obj 3048 0 R /Pg 139 0 R /Type /OBJR >> ] /P 1785 0 R /Pg 139 0 R /S /Link >> endobj %% Original object ID: 10971 0 4299 0 obj << /K [ 1 << /Obj 3049 0 R /Pg 140 0 R /Type /OBJR >> ] /P 1786 0 R /Pg 140 0 R /S /Link >> endobj %% Original object ID: 10973 0 4300 0 obj << /K [ 4 << /Obj 3050 0 R /Pg 140 0 R /Type /OBJR >> ] /P 1787 0 R /Pg 140 0 R /S /Link >> endobj %% Original object ID: 10975 0 4301 0 obj << /K [ 7 << /Obj 3051 0 R /Pg 140 0 R /Type /OBJR >> ] /P 1788 0 R /Pg 140 0 R /S /Link >> endobj %% Original object ID: 10977 0 4302 0 obj << /K [ 10 << /Obj 3052 0 R /Pg 140 0 R /Type /OBJR >> ] /P 1789 0 R /Pg 140 0 R /S /Link >> endobj %% Original object ID: 10979 0 4303 0 obj << /K [ 13 << /Obj 3053 0 R /Pg 140 0 R /Type /OBJR >> ] /P 1790 0 R /Pg 140 0 R /S /Link >> endobj %% Original object ID: 10981 0 4304 0 obj << /K [ 16 << /Obj 3054 0 R /Pg 140 0 R /Type /OBJR >> ] /P 1791 0 R /Pg 140 0 R /S /Link >> endobj %% Original object ID: 10983 0 4305 0 obj << /K [ 19 << /Obj 3055 0 R /Pg 140 0 R /Type /OBJR >> ] /P 1792 0 R /Pg 140 0 R /S /Link >> endobj %% Original object ID: 10985 0 4306 0 obj << /K [ 22 << /Obj 3056 0 R /Pg 140 0 R /Type /OBJR >> ] /P 1793 0 R /Pg 140 0 R /S /Link >> endobj %% Original object ID: 10987 0 4307 0 obj << /K [ 25 << /Obj 3057 0 R /Pg 140 0 R /Type /OBJR >> ] /P 1794 0 R /Pg 140 0 R /S /Link >> endobj %% Original object ID: 10989 0 4308 0 obj << /K [ 28 << /Obj 3058 0 R /Pg 140 0 R /Type /OBJR >> ] /P 1795 0 R /Pg 140 0 R /S /Link >> endobj %% Original object ID: 10991 0 4309 0 obj << /K [ 31 << /Obj 3059 0 R /Pg 140 0 R /Type /OBJR >> ] /P 1796 0 R /Pg 140 0 R /S /Link >> endobj %% Original object ID: 10993 0 4310 0 obj << /K [ 34 << /Obj 3060 0 R /Pg 140 0 R /Type /OBJR >> ] /P 1797 0 R /Pg 140 0 R /S /Link >> endobj %% Original object ID: 10995 0 4311 0 obj << /K [ 39 << /Obj 3061 0 R /Pg 140 0 R /Type /OBJR >> ] /P 1800 0 R /Pg 140 0 R /S /Link >> endobj %% Original object ID: 10997 0 4312 0 obj << /K [ 42 << /Obj 3062 0 R /Pg 140 0 R /Type /OBJR >> ] /P 1801 0 R /Pg 140 0 R /S /Link >> endobj %% Original object ID: 10999 0 4313 0 obj << /K [ 45 << /Obj 3063 0 R /Pg 140 0 R /Type /OBJR >> ] /P 1802 0 R /Pg 140 0 R /S /Link >> endobj %% Original object ID: 11001 0 4314 0 obj << /K [ 4 << /Obj 3065 0 R /Pg 141 0 R /Type /OBJR >> ] /P 1804 0 R /Pg 141 0 R /S /Link >> endobj %% Original object ID: 11003 0 4315 0 obj << /K [ 7 << /Obj 3066 0 R /Pg 141 0 R /Type /OBJR >> ] /P 1805 0 R /Pg 141 0 R /S /Link >> endobj %% Original object ID: 11005 0 4316 0 obj << /K [ 10 << /Obj 3067 0 R /Pg 141 0 R /Type /OBJR >> ] /P 1806 0 R /Pg 141 0 R /S /Link >> endobj %% Original object ID: 11007 0 4317 0 obj << /K [ 13 << /Obj 3068 0 R /Pg 141 0 R /Type /OBJR >> ] /P 1807 0 R /Pg 141 0 R /S /Link >> endobj %% Original object ID: 11009 0 4318 0 obj << /K [ 16 << /Obj 3069 0 R /Pg 141 0 R /Type /OBJR >> ] /P 1808 0 R /Pg 141 0 R /S /Link >> endobj %% Original object ID: 11011 0 4319 0 obj << /K [ 19 << /Obj 3070 0 R /Pg 141 0 R /Type /OBJR >> ] /P 1809 0 R /Pg 141 0 R /S /Link >> endobj %% Original object ID: 11013 0 4320 0 obj << /K [ 22 << /Obj 3071 0 R /Pg 141 0 R /Type /OBJR >> ] /P 1810 0 R /Pg 141 0 R /S /Link >> endobj %% Original object ID: 11015 0 4321 0 obj << /K [ 25 << /Obj 3072 0 R /Pg 141 0 R /Type /OBJR >> ] /P 1811 0 R /Pg 141 0 R /S /Link >> endobj %% Original object ID: 11017 0 4322 0 obj << /K [ 28 << /Obj 3073 0 R /Pg 141 0 R /Type /OBJR >> ] /P 1812 0 R /Pg 141 0 R /S /Link >> endobj %% Original object ID: 11019 0 4323 0 obj << /K [ 31 << /Obj 3074 0 R /Pg 141 0 R /Type /OBJR >> ] /P 1813 0 R /Pg 141 0 R /S /Link >> endobj %% Original object ID: 11021 0 4324 0 obj << /K [ 34 << /Obj 3075 0 R /Pg 141 0 R /Type /OBJR >> ] /P 1814 0 R /Pg 141 0 R /S /Link >> endobj %% Original object ID: 11023 0 4325 0 obj << /K [ 37 << /Obj 3076 0 R /Pg 141 0 R /Type /OBJR >> ] /P 1815 0 R /Pg 141 0 R /S /Link >> endobj %% Original object ID: 11025 0 4326 0 obj << /K [ 40 << /Obj 3077 0 R /Pg 141 0 R /Type /OBJR >> ] /P 1816 0 R /Pg 141 0 R /S /Link >> endobj %% Original object ID: 11027 0 4327 0 obj << /K [ 43 << /Obj 3078 0 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[ << /Obj 2168 0 R /Pg 23 0 R /Type /OBJR >> 7985 0 R ] /P 6338 0 R /S /Link >> endobj %% Original object ID: 1951 0 4565 0 obj << /K [ << /Obj 2169 0 R /Pg 23 0 R /Type /OBJR >> 7986 0 R ] /P 6338 0 R /S /Link >> endobj %% Original object ID: 1952 0 4566 0 obj << /K [ << /Obj 2170 0 R /Pg 23 0 R /Type /OBJR >> 7990 0 R ] /P 6340 0 R /S /Link >> endobj %% Original object ID: 1953 0 4567 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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2192 0 R /Pg 25 0 R /Type /OBJR >> 1351 1352 8105 0 R ] /P 6390 0 R /Pg 25 0 R /S /Link >> endobj %% Original object ID: 1959 0 4573 0 obj << /K [ << /Obj 2191 0 R /Pg 25 0 R /Type /OBJR >> 8104 0 R ] /P 6393 0 R /S /Link >> endobj %% Original object ID: 1960 0 4574 0 obj << /K [ << /Obj 2185 0 R /Type /OBJR >> << /Obj 2184 0 R /Pg 25 0 R /Type /OBJR >> 1302 1303 8086 0 R ] /P 6394 0 R /Pg 25 0 R /S /Link >> endobj %% Original object ID: 1961 0 4575 0 obj << /K [ << /Obj 2188 0 R /Type /OBJR >> << /Obj 2187 0 R /Type /OBJR >> << /Obj 2186 0 R /Pg 25 0 R /Type /OBJR >> 1318 1319 1320 8093 0 R ] /P 6401 0 R /Pg 25 0 R /S /Link >> endobj %% Original object ID: 1962 0 4576 0 obj << /K [ << /Obj 2189 0 R /Pg 25 0 R /Type /OBJR >> 8095 0 R ] /P 6402 0 R /S /Link >> endobj %% Original object ID: 1963 0 4577 0 obj << /K [ << /Obj 2190 0 R /Pg 25 0 R /Type /OBJR >> 8100 0 R ] /P 6405 0 R /S /Link >> endobj %% Original object ID: 1964 0 4578 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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0 R 8119 0 R 8120 0 R 8120 0 R 8121 0 R 8120 0 R 8122 0 R 8123 0 R 8123 0 R 8124 0 R 8125 0 R 8126 0 R 8127 0 R 6421 0 R 6422 0 R 6423 0 R 8128 0 R 6426 0 R 8129 0 R 8130 0 R 8130 0 R 8131 0 R 8132 0 R 8133 0 R 8134 0 R 8135 0 R 8136 0 R 8136 0 R 6428 0 R 8137 0 R 8138 0 R 8139 0 R 6411 0 R 8140 0 R 8141 0 R 8141 0 R 8141 0 R 8141 0 R 6414 0 R 6414 0 R 6416 0 R 6418 0 R 6418 0 R 8142 0 R 8143 0 R 6418 0 R 6431 0 R 6431 0 R 8144 0 R 6424 0 R 6424 0 R 6424 0 R 6424 0 R 6424 0 R 8145 0 R 6430 0 R 6430 0 R 6430 0 R 6430 0 R 8146 0 R 4579 0 R 4579 0 R 4579 0 R 8147 0 R 4580 0 R 4580 0 R 4580 0 R 4580 0 R 8148 0 R 8149 0 R 6432 0 R 6432 0 R 8150 0 R 4581 0 R 8151 0 R 6433 0 R 6433 0 R 8152 0 R 8153 0 R 6434 0 R 8154 0 R 6435 0 R ] endobj %% Original object ID: 1965 0 4579 0 obj << /K [ << /Obj 2200 0 R /Type /OBJR >> << /Obj 2199 0 R /Type /OBJR >> << /Obj 2198 0 R /Type /OBJR >> << /Obj 2197 0 R /Pg 26 0 R /Type /OBJR >> 1444 1445 1446 8147 0 R ] /P 6413 0 R /Pg 26 0 R /S /Link >> endobj %% Original object ID: 1966 0 4580 0 obj << /K [ << /Obj 2205 0 R /Type /OBJR >> << /Obj 2204 0 R /Type /OBJR >> << /Obj 2203 0 R /Type /OBJR >> << /Obj 2202 0 R /Type /OBJR >> << /Obj 2201 0 R /Pg 26 0 R /Type /OBJR >> 1448 1449 1450 1451 8148 0 R ] /P 6425 0 R /Pg 26 0 R /S /Link >> endobj %% Original object ID: 1967 0 4581 0 obj << /K [ << /Obj 2206 0 R /Pg 26 0 R /Type /OBJR >> 8150 0 R 1457 ] /P 6432 0 R /Pg 26 0 R /S /Link >> endobj %% Original object ID: 1968 0 4582 0 obj << /K [ << /Obj 2207 0 R /Pg 26 0 R /Type /OBJR >> 8153 0 R ] /P 6434 0 R /S /Link >> endobj %% Original object ID: 1969 0 4583 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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0 R 6450 0 R 6450 0 R 6443 0 R 6453 0 R 8155 0 R 6441 0 R 6442 0 R 6440 0 R 6440 0 R 6444 0 R 8156 0 R 6444 0 R 8157 0 R 8158 0 R 8159 0 R 8158 0 R 8158 0 R 8158 0 R 8160 0 R 8161 0 R 8161 0 R 8162 0 R 8161 0 R 8161 0 R 8161 0 R 8161 0 R 8161 0 R 8163 0 R 8161 0 R 8161 0 R 6451 0 R 6451 0 R 6451 0 R 6451 0 R 6445 0 R 6446 0 R 6447 0 R 6448 0 R 6448 0 R 6448 0 R 6448 0 R 8164 0 R 6454 0 R 6454 0 R 6455 0 R 6456 0 R 6456 0 R 6456 0 R 8165 0 R 8166 0 R 8167 0 R 8168 0 R 8168 0 R 8169 0 R 8170 0 R 8171 0 R 8172 0 R 8173 0 R 8174 0 R 8175 0 R 8175 0 R 8175 0 R 8176 0 R 8177 0 R 4585 0 R 4585 0 R 4585 0 R 8178 0 R 8179 0 R 8180 0 R 6469 0 R 8181 0 R 6470 0 R 8182 0 R 6471 0 R 8183 0 R 6472 0 R 8184 0 R 8185 0 R 8186 0 R 6473 0 R 8187 0 R 8188 0 R 6449 0 R 6449 0 R 6449 0 R 6449 0 R 6449 0 R 6464 0 R 6464 0 R 6464 0 R 6464 0 R 6464 0 R 6464 0 R 8189 0 R 8190 0 R 8191 0 R 8192 0 R 8191 0 R 8191 0 R 8193 0 R 8194 0 R 8195 0 R 8194 0 R 8194 0 R 8194 0 R 8194 0 R 8196 0 R 8194 0 R 6462 0 R 6462 0 R 6462 0 R 6462 0 R 6466 0 R 6466 0 R 6467 0 R 6468 0 R 6468 0 R 6468 0 R 6459 0 R 6459 0 R 6460 0 R 6461 0 R 6461 0 R 8197 0 R 8198 0 R 6461 0 R 8199 0 R 8200 0 R 8200 0 R 8200 0 R 8201 0 R 8202 0 R 8203 0 R 8203 0 R 8203 0 R 8204 0 R 8205 0 R ] endobj %% Original object ID: 1970 0 4584 0 obj << /K [ << /Obj 2218 0 R /Pg 27 0 R /Type /OBJR >> << /Obj 2217 0 R /Pg 27 0 R /Type /OBJR >> 8187 0 R 8188 0 R ] /P 6439 0 R /S /Link >> endobj %% Original object ID: 1971 0 4585 0 obj << /K [ << /Obj 2214 0 R /Type /OBJR >> << /Obj 2213 0 R /Type /OBJR >> << /Obj 2212 0 R /Type /OBJR >> << /Obj 2211 0 R /Pg 27 0 R /Type /OBJR >> 1536 1537 1538 8178 0 R ] /P 8206 0 R /Pg 27 0 R /S /Link >> endobj %% Original object ID: 1972 0 4586 0 obj << /K [ << /Obj 2219 0 R /Pg 27 0 R /Type /OBJR >> 8197 0 R ] /P 6461 0 R /S /Link >> endobj %% Original object ID: 1973 0 4587 0 obj << /K [ << /Obj 2215 0 R /Pg 27 0 R /Type /OBJR >> 8180 0 R ] /P 6469 0 R /S /Link >> endobj %% Original object ID: 1974 0 4588 0 obj << /K [ << /Obj 2216 0 R /Pg 27 0 R /Type /OBJR >> 8186 0 R ] /P 6473 0 R /S /Link >> endobj %% Original object ID: 1975 0 4589 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 6499 0 R 6476 0 R 6475 0 R 8207 0 R 6475 0 R 6477 0 R 8208 0 R 8209 0 R 8210 0 R 8211 0 R 8212 0 R 8213 0 R 8214 0 R 8215 0 R 8216 0 R 8217 0 R 8218 0 R 8219 0 R 8220 0 R 8221 0 R 8222 0 R 8223 0 R 6482 0 R 8224 0 R 8225 0 R 8226 0 R 8227 0 R 8228 0 R 8229 0 R 8230 0 R 8231 0 R 8232 0 R 8233 0 R 8234 0 R 8235 0 R 8236 0 R 8237 0 R 8238 0 R 8239 0 R 6487 0 R 8240 0 R 8241 0 R 8242 0 R 8243 0 R 8244 0 R 8245 0 R 8246 0 R 8247 0 R 8248 0 R 6481 0 R 6481 0 R 6481 0 R 6481 0 R 6481 0 R 6481 0 R 6481 0 R 6484 0 R 6485 0 R 6485 0 R 6485 0 R 6485 0 R 6485 0 R 6485 0 R 6479 0 R 6479 0 R 8249 0 R 8250 0 R 6486 0 R 6486 0 R 8251 0 R 8252 0 R 6491 0 R 6492 0 R 8253 0 R 8254 0 R 8255 0 R 8256 0 R 6494 0 R 8257 0 R 6495 0 R 8258 0 R 6496 0 R 8259 0 R 6497 0 R 6497 0 R 6497 0 R 6498 0 R 6498 0 R 6498 0 R 8260 0 R 8261 0 R 6498 0 R 6489 0 R 8262 0 R 8263 0 R ] endobj %% Original object ID: 1976 0 4590 0 obj << /K [ << /Obj 2223 0 R /Pg 28 0 R /Type /OBJR >> 8249 0 R ] /P 6480 0 R /S /Link >> endobj %% Original object ID: 1977 0 4591 0 obj << /K [ << /Obj 2224 0 R /Pg 28 0 R /Type /OBJR >> 8251 0 R ] /P 6486 0 R /S /Link >> endobj %% Original object ID: 1978 0 4592 0 obj << /K [ << /Obj 2228 0 R /Pg 28 0 R /Type /OBJR >> 8262 0 R ] /P 6490 0 R /S /Link >> endobj %% Original object ID: 1979 0 4593 0 obj << /K [ << /Obj 2225 0 R /Pg 28 0 R /Type /OBJR >> 8253 0 R ] /P 6493 0 R /S /Link >> endobj %% Original object ID: 1980 0 4594 0 obj << /K [ << /Obj 2227 0 R /Pg 28 0 R /Type /OBJR >> << /Obj 2226 0 R /Pg 28 0 R /Type /OBJR >> 8260 0 R 8261 0 R ] /P 6498 0 R /S /Link >> endobj %% Original object ID: 1981 0 4595 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 6515 0 R 6507 0 R 6507 0 R 6507 0 R 6507 0 R 6507 0 R 6507 0 R 6507 0 R 8264 0 R 8265 0 R 8266 0 R 8267 0 R 6502 0 R 6502 0 R 6502 0 R 6502 0 R 6502 0 R 8268 0 R 6502 0 R 6502 0 R 8269 0 R 6503 0 R 8270 0 R 8271 0 R 4596 0 R 4596 0 R 4596 0 R 8272 0 R 8273 0 R 8274 0 R 8274 0 R 8274 0 R 8275 0 R 8276 0 R 8277 0 R 8278 0 R 8279 0 R 8280 0 R 6510 0 R 8281 0 R 8282 0 R 6511 0 R 6511 0 R 8283 0 R 6512 0 R 8284 0 R 6513 0 R 8285 0 R 6514 0 R 6514 0 R 6514 0 R 6514 0 R 6500 0 R 6508 0 R 6508 0 R 6508 0 R 6504 0 R 6504 0 R 6504 0 R 6504 0 R 6504 0 R 6505 0 R 6505 0 R 6505 0 R 6505 0 R 6509 0 R 6509 0 R 6509 0 R 8286 0 R 8287 0 R 8287 0 R 8287 0 R 8287 0 R 8287 0 R 8288 0 R 8289 0 R 8290 0 R 8290 0 R 8290 0 R 8290 0 R 8290 0 R 8291 0 R ] endobj %% Original object ID: 1982 0 4596 0 obj << /K [ << /Obj 2236 0 R /Type /OBJR >> << /Obj 2235 0 R /Type /OBJR >> << /Obj 2234 0 R /Type /OBJR >> << /Obj 2233 0 R /Pg 29 0 R /Type /OBJR >> 1729 1730 1731 8272 0 R ] /P 8292 0 R /Pg 29 0 R /S /Link >> endobj %% Original object ID: 1983 0 4597 0 obj << /K [ << /Obj 2238 0 R /Pg 29 0 R /Type /OBJR >> << /Obj 2237 0 R /Pg 29 0 R /Type /OBJR >> 8276 0 R 8277 0 R ] /P 8274 0 R /S /Link >> endobj %% Original object ID: 1984 0 4598 0 obj << /K [ << /Obj 2232 0 R /Pg 29 0 R /Type /OBJR >> 8266 0 R ] /P 6507 0 R /S /Link >> endobj %% Original object ID: 1985 0 4599 0 obj << /K [ << /Obj 2239 0 R /Pg 29 0 R /Type /OBJR >> 8280 0 R ] /P 6510 0 R /S /Link >> endobj %% Original object ID: 1986 0 4600 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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0 R 8300 0 R 8300 0 R 6522 0 R 6522 0 R 6522 0 R 8301 0 R 8302 0 R 8302 0 R 8303 0 R 8304 0 R 8304 0 R 8304 0 R 8304 0 R 8304 0 R 8304 0 R 8304 0 R 8305 0 R 6517 0 R 6517 0 R 6517 0 R 6518 0 R 6519 0 R 6519 0 R 6519 0 R 8306 0 R 8307 0 R 8308 0 R 8309 0 R 8309 0 R 8309 0 R 6529 0 R 8310 0 R 8311 0 R 8311 0 R 8312 0 R 8313 0 R 8313 0 R 8313 0 R 8314 0 R 4601 0 R 4601 0 R 4601 0 R 8315 0 R 8316 0 R 8317 0 R 8317 0 R 8317 0 R 8318 0 R 8319 0 R 8320 0 R 6516 0 R 8321 0 R 8322 0 R 8323 0 R 8324 0 R 6530 0 R 8325 0 R 6531 0 R 6531 0 R 6531 0 R 6531 0 R 8326 0 R 6532 0 R 6532 0 R 8327 0 R 6533 0 R ] endobj %% Original object ID: 1987 0 4601 0 obj << /K [ << /Obj 2247 0 R /Type /OBJR >> << /Obj 2246 0 R /Type /OBJR >> << /Obj 2245 0 R /Type /OBJR >> << /Obj 2244 0 R /Pg 30 0 R /Type /OBJR >> 1851 1852 1853 8315 0 R ] /P 8328 0 R /Pg 30 0 R /S /Link >> endobj %% Original object ID: 1988 0 4602 0 obj << /K [ << /Obj 2249 0 R /Pg 30 0 R /Type /OBJR >> << /Obj 2248 0 R /Pg 30 0 R /Type /OBJR >> 8319 0 R 8320 0 R ] /P 8317 0 R /S /Link >> endobj %% Original object ID: 1989 0 4603 0 obj << /K [ << /Obj 2243 0 R /Pg 30 0 R /Type /OBJR >> 8294 0 R ] /P 6526 0 R /S /Link >> endobj %% Original object ID: 1990 0 4604 0 obj << /K [ << /Obj 2250 0 R /Pg 30 0 R /Type /OBJR >> 8324 0 R ] /P 6530 0 R /S /Link >> endobj %% Original object ID: 1991 0 4605 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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8342 0 R 8342 0 R 8342 0 R 8342 0 R 8342 0 R 8342 0 R 6537 0 R 6540 0 R 6540 0 R 6540 0 R 6540 0 R 8343 0 R 8344 0 R 6539 0 R 6539 0 R 6539 0 R 6539 0 R 6539 0 R 6539 0 R 6539 0 R 6539 0 R 6539 0 R 6548 0 R 6549 0 R 8345 0 R 6547 0 R 6547 0 R 6547 0 R 6547 0 R 6547 0 R 6541 0 R 6541 0 R 8346 0 R 6541 0 R 8347 0 R 4606 0 R 6543 0 R 6543 0 R 8348 0 R 6543 0 R 8349 0 R 4607 0 R 6543 0 R 6544 0 R 6545 0 R 6545 0 R 8350 0 R 8351 0 R 8352 0 R 6535 0 R ] endobj %% Original object ID: 1992 0 4606 0 obj << /K [ << /Obj 2255 0 R /Pg 31 0 R /Type /OBJR >> 8347 0 R 1940 ] /P 6541 0 R /Pg 31 0 R /S /Link >> endobj %% Original object ID: 1993 0 4607 0 obj << /K [ << /Obj 2256 0 R /Pg 31 0 R /Type /OBJR >> 8349 0 R 1946 ] /P 6543 0 R /Pg 31 0 R /S /Link >> endobj %% Original object ID: 1994 0 4608 0 obj << /K [ << /Obj 2257 0 R /Pg 31 0 R /Type /OBJR >> 8352 0 R ] /P 6545 0 R /S /Link >> endobj %% Original object ID: 1995 0 4609 0 obj << /K [ << /Obj 2254 0 R /Pg 31 0 R /Type /OBJR >> 8332 0 R ] /P 6552 0 R /S /Link >> endobj %% Original object ID: 1996 0 4610 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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8362 0 R 6565 0 R 6566 0 R 6567 0 R 6568 0 R 6569 0 R 8363 0 R 8364 0 R 8365 0 R 8366 0 R 8364 0 R 8367 0 R 8368 0 R 8369 0 R 6571 0 R 6572 0 R 6572 0 R 6586 0 R 6575 0 R 8370 0 R 6576 0 R 6577 0 R 8371 0 R 6578 0 R 8372 0 R 8373 0 R 6579 0 R 6554 0 R 8374 0 R 8375 0 R 6580 0 R 8376 0 R 8377 0 R 8378 0 R 6581 0 R 8379 0 R 6582 0 R 6582 0 R 6582 0 R 6582 0 R 6582 0 R 6582 0 R 6582 0 R 6582 0 R 8380 0 R 6583 0 R 6583 0 R 8381 0 R 8382 0 R 6583 0 R 8383 0 R 6584 0 R 8384 0 R 6585 0 R 6556 0 R 6557 0 R 8385 0 R 8386 0 R 8387 0 R 8387 0 R 8388 0 R 8389 0 R 8389 0 R 6559 0 R 8390 0 R 6560 0 R 6561 0 R 6561 0 R 6561 0 R 6573 0 R 6573 0 R 6573 0 R 6573 0 R ] endobj %% Original object ID: 1997 0 4611 0 obj << /K [ << /Obj 2266 0 R /Pg 32 0 R /Type /OBJR >> 8385 0 R ] /P 6557 0 R /S /Link >> endobj %% Original object ID: 1998 0 4612 0 obj << /K [ << /Obj 2261 0 R /Pg 32 0 R /Type /OBJR >> 8369 0 R ] /P 8368 0 R /S /Link >> endobj %% Original object ID: 1999 0 4613 0 obj << /K [ << /Obj 2262 0 R /Pg 32 0 R /Type /OBJR >> 8372 0 R ] /P 6579 0 R /S /Link >> endobj %% Original object ID: 2000 0 4614 0 obj << /K [ << /Obj 2263 0 R /Pg 32 0 R /Type /OBJR >> 8375 0 R ] /P 6580 0 R /S /Link >> endobj %% Original object ID: 2001 0 4615 0 obj << /K [ << /Obj 2264 0 R /Pg 32 0 R /Type /OBJR >> 8378 0 R ] /P 6581 0 R /S /Link >> endobj %% Original object ID: 2002 0 4616 0 obj << /K [ << /Obj 2265 0 R /Pg 32 0 R /Type /OBJR >> 8382 0 R ] /P 6583 0 R /S /Link >> endobj %% Original object ID: 2003 0 4617 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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8407 0 R 8407 0 R 8408 0 R 8407 0 R 8409 0 R 8407 0 R 8407 0 R 8410 0 R 8411 0 R 8412 0 R 8413 0 R 8413 0 R 8414 0 R 8415 0 R 8416 0 R 8417 0 R 8418 0 R 8419 0 R 8417 0 R 8420 0 R 8421 0 R 6601 0 R 8422 0 R 8423 0 R 8424 0 R 6602 0 R 8425 0 R 6603 0 R 8426 0 R 6604 0 R 6604 0 R 6604 0 R 8427 0 R 6605 0 R 6605 0 R 6605 0 R 8428 0 R 6606 0 R 6606 0 R 8429 0 R 8430 0 R 8431 0 R 6607 0 R 6607 0 R 6607 0 R 6607 0 R 6607 0 R 6607 0 R 6607 0 R 6607 0 R 8432 0 R 6608 0 R 6608 0 R 6596 0 R 6596 0 R 6596 0 R 6596 0 R 6596 0 R 6596 0 R 6596 0 R 6598 0 R 6590 0 R 6590 0 R 6590 0 R 6590 0 R 6592 0 R 6594 0 R 6594 0 R 6594 0 R 6594 0 R 6594 0 R 6594 0 R 8433 0 R 8434 0 R 8435 0 R 8436 0 R 8437 0 R 8438 0 R 8438 0 R 8438 0 R 8439 0 R 8440 0 R 8441 0 R 8441 0 R 8441 0 R 8441 0 R 8441 0 R 8441 0 R 8441 0 R 8441 0 R 8441 0 R 8441 0 R 8441 0 R 8441 0 R 8441 0 R 8442 0 R 8443 0 R ] endobj %% Original object ID: 2004 0 4618 0 obj << /K [ << /Obj 2271 0 R /Pg 33 0 R /Type /OBJR >> << /Obj 2270 0 R /Pg 33 0 R /Type /OBJR >> 8410 0 R 8411 0 R ] /P 8407 0 R /S /Link >> endobj %% Original object ID: 2005 0 4619 0 obj << /K [ << /Obj 2272 0 R /Pg 33 0 R /Type /OBJR >> 8415 0 R ] /P 8413 0 R /S /Link >> endobj %% Original object ID: 2006 0 4620 0 obj << /K [ << /Obj 2273 0 R /Pg 33 0 R /Type /OBJR >> 8419 0 R ] /P 8417 0 R /S /Link >> endobj %% Original object ID: 2007 0 4621 0 obj << /K [ << /Obj 2278 0 R /Pg 33 0 R /Type /OBJR >> 8433 0 R ] /P 6597 0 R /S /Link >> endobj %% Original object ID: 2008 0 4622 0 obj << /K [ << /Obj 2279 0 R /Pg 33 0 R /Type /OBJR >> 8435 0 R ] /P 6599 0 R /S /Link >> endobj %% Original object ID: 2009 0 4623 0 obj << /K [ << /Obj 2274 0 R /Pg 33 0 R /Type /OBJR >> 8421 0 R ] /P 6601 0 R /S /Link >> endobj %% Original object ID: 2010 0 4624 0 obj << /K [ << /Obj 2275 0 R /Pg 33 0 R /Type /OBJR >> 8424 0 R ] /P 6602 0 R /S /Link >> endobj %% Original object ID: 2011 0 4625 0 obj << /K [ << /Obj 2277 0 R /Pg 33 0 R /Type /OBJR >> << /Obj 2276 0 R /Pg 33 0 R /Type /OBJR >> 8429 0 R 8430 0 R ] /P 6606 0 R /S /Link >> endobj %% Original object ID: 2012 0 4626 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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0 R 8447 0 R 8448 0 R 8448 0 R 8449 0 R 8448 0 R 8450 0 R 8451 0 R 8452 0 R 8453 0 R 8454 0 R 8455 0 R 8453 0 R 8456 0 R 8457 0 R 8457 0 R 8457 0 R 8458 0 R 8459 0 R 8459 0 R 8459 0 R 8460 0 R 8461 0 R 8462 0 R 8461 0 R 8463 0 R 8464 0 R 8464 0 R 8465 0 R 8466 0 R 8467 0 R 8468 0 R 8469 0 R 8467 0 R 6610 0 R 8470 0 R 6614 0 R 8471 0 R 8472 0 R 8473 0 R 8474 0 R 8475 0 R 8476 0 R 8477 0 R 8478 0 R 8479 0 R 8480 0 R 8481 0 R 8482 0 R 8483 0 R 8484 0 R 8485 0 R 8486 0 R 8487 0 R 8488 0 R 8489 0 R 8490 0 R 8491 0 R 8492 0 R 8493 0 R 8494 0 R 8495 0 R 8496 0 R 8497 0 R 8498 0 R 8499 0 R 8500 0 R 8501 0 R 8502 0 R 8503 0 R 8504 0 R 8505 0 R 8506 0 R 8505 0 R 8505 0 R 8505 0 R 8507 0 R 8508 0 R 8508 0 R 8509 0 R 8510 0 R 8511 0 R 8512 0 R 8513 0 R 8514 0 R 8515 0 R 8516 0 R 8517 0 R 8518 0 R 8519 0 R 8520 0 R 8519 0 R 8521 0 R 8522 0 R 8522 0 R 8522 0 R 8523 0 R 8524 0 R 8524 0 R 8524 0 R 8525 0 R 8526 0 R 8527 0 R 8528 0 R 8528 0 R 8529 0 R 8530 0 R 8531 0 R 8532 0 R 8533 0 R 8531 0 R 6612 0 R ] endobj %% Original object ID: 2013 0 4627 0 obj << /K [ << /Obj 2285 0 R /Pg 34 0 R /Type /OBJR >> 8515 0 R ] /P 8513 0 R /S /Link >> endobj %% Original object ID: 2014 0 4628 0 obj << /K [ << /Obj 2286 0 R /Pg 34 0 R /Type /OBJR >> 8533 0 R ] /P 8531 0 R /S /Link >> endobj %% Original object ID: 2015 0 4629 0 obj << /K [ << /Obj 2283 0 R /Pg 34 0 R /Type /OBJR >> 8469 0 R ] /P 8467 0 R /S /Link >> endobj %% Original object ID: 2016 0 4630 0 obj << /K [ << /Obj 2284 0 R /Pg 34 0 R /Type /OBJR >> 8479 0 R ] /P 6617 0 R /S /Link >> endobj %% Original object ID: 2017 0 4631 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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null null null null null 8534 0 R 6658 0 R 6658 0 R 6658 0 R 6658 0 R 6658 0 R 6658 0 R 6658 0 R 6658 0 R 8535 0 R 8536 0 R 4636 0 R 6658 0 R 6658 0 R 8537 0 R 6659 0 R 6659 0 R 8538 0 R 8539 0 R 6660 0 R 6660 0 R 6660 0 R 8540 0 R 6661 0 R 6661 0 R 6661 0 R 8541 0 R 6662 0 R 6662 0 R 6662 0 R 8542 0 R 8543 0 R 6663 0 R 6670 0 R 6625 0 R 6626 0 R 6627 0 R 6628 0 R 6640 0 R 6641 0 R 8544 0 R 6641 0 R 8545 0 R 8546 0 R 8547 0 R 8548 0 R 8548 0 R 8548 0 R 8548 0 R 8549 0 R 8550 0 R 8550 0 R 8550 0 R 8551 0 R 8550 0 R 8552 0 R 8553 0 R 8553 0 R 8553 0 R 8553 0 R 8554 0 R 6633 0 R 6633 0 R 6633 0 R 6634 0 R 6634 0 R 6634 0 R 6634 0 R 6634 0 R 6630 0 R 6631 0 R 6632 0 R 8555 0 R 6629 0 R 6629 0 R 6629 0 R 6629 0 R 8556 0 R 6635 0 R 6638 0 R 6639 0 R 8557 0 R 6646 0 R 6643 0 R 6643 0 R 6643 0 R 6643 0 R 6643 0 R 6645 0 R 6645 0 R 6644 0 R 6644 0 R 6644 0 R 8558 0 R 6653 0 R 6653 0 R 6653 0 R 8559 0 R 6654 0 R 6655 0 R 6655 0 R 8560 0 R 6647 0 R 6648 0 R 6650 0 R 6652 0 R 6652 0 R 8561 0 R 8562 0 R 8562 0 R 8562 0 R 8562 0 R 8562 0 R 8563 0 R 8564 0 R 8565 0 R 8566 0 R 8567 0 R 8568 0 R 8569 0 R 6664 0 R 6665 0 R 6666 0 R 8570 0 R 6667 0 R 6667 0 R 6668 0 R 6668 0 R 8571 0 R 8572 0 R 6657 0 R ] endobj %% Original object ID: 2018 0 4632 0 obj << /K [ << /Obj 2293 0 R /Pg 35 0 R /Type /OBJR >> 8557 0 R ] /P 6636 0 R /S /Link >> endobj %% Original object ID: 2019 0 4633 0 obj << /K [ << /Obj 2292 0 R /Pg 35 0 R /Type /OBJR >> 8546 0 R ] /P 6642 0 R /S /Link >> endobj %% Original object ID: 2020 0 4634 0 obj << /K [ << /Obj 2294 0 R /Pg 35 0 R /Type /OBJR >> 8558 0 R ] /P 6644 0 R /S /Link >> endobj %% Original object ID: 2021 0 4635 0 obj << /K [ << /Obj 2299 0 R /Pg 35 0 R /Type /OBJR >> << /Obj 2298 0 R /Pg 35 0 R /Type /OBJR >> << /Obj 2297 0 R /Pg 35 0 R /Type /OBJR >> << /Obj 2296 0 R /Pg 35 0 R /Type /OBJR >> << /Obj 2295 0 R /Pg 35 0 R /Type /OBJR >> 8565 0 R 8566 0 R 8567 0 R 8568 0 R 8569 0 R ] /P 8573 0 R /S /Link >> endobj %% Original object ID: 2022 0 4636 0 obj << /K [ << /Obj 2290 0 R /Pg 35 0 R /Type /OBJR >> 8536 0 R 2298 ] /P 6658 0 R /Pg 35 0 R /S /Link >> endobj %% Original object ID: 2023 0 4637 0 obj << /K [ << /Obj 2291 0 R /Pg 35 0 R /Type /OBJR >> 8543 0 R ] /P 6663 0 R /S /Link >> endobj %% Original object ID: 2024 0 4638 0 obj << /K [ << /Obj 2300 0 R /Pg 35 0 R /Type /OBJR >> 8571 0 R ] /P 6669 0 R /S /Link >> endobj %% Original object ID: 2025 0 4639 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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0 R 6679 0 R 6680 0 R 6680 0 R 6680 0 R 8592 0 R 6686 0 R 6686 0 R 6687 0 R 6688 0 R 6688 0 R 6688 0 R 8593 0 R 8594 0 R 8595 0 R 8596 0 R 8596 0 R 8597 0 R 8598 0 R 8599 0 R 8600 0 R 8601 0 R 6683 0 R 6683 0 R 6683 0 R 6683 0 R 6683 0 R 6696 0 R 6696 0 R 6696 0 R 6696 0 R 6696 0 R 6696 0 R 8602 0 R 8603 0 R 8604 0 R 8605 0 R 8604 0 R 8604 0 R 8606 0 R 8607 0 R 8608 0 R 8607 0 R 8607 0 R 8607 0 R 8607 0 R 8609 0 R 8607 0 R 8607 0 R 6694 0 R 6694 0 R 6694 0 R 6694 0 R 6698 0 R 6698 0 R 6699 0 R 6700 0 R 6700 0 R 6700 0 R 6692 0 R 6692 0 R 8610 0 R 6692 0 R 6693 0 R 6693 0 R 6693 0 R 8611 0 R 6693 0 R 8612 0 R 8613 0 R 8613 0 R 8613 0 R 8614 0 R 8615 0 R 8616 0 R 8616 0 R 8616 0 R 8617 0 R 8618 0 R 8619 0 R 8620 0 R 8620 0 R 8620 0 R 8621 0 R 8622 0 R 8623 0 R 8624 0 R 8625 0 R 8626 0 R ] endobj %% Original object ID: 2026 0 4640 0 obj << /K [ << /Obj 2305 0 R /Type /OBJR >> << /Obj 2304 0 R /Pg 36 0 R /Type /OBJR >> 2421 2422 8574 0 R ] /P 6673 0 R /Pg 36 0 R /S /Link >> endobj %% Original object ID: 2027 0 4641 0 obj << /K [ << /Obj 2312 0 R /Pg 36 0 R /Type /OBJR >> << /Obj 2311 0 R /Pg 36 0 R /Type /OBJR >> << /Obj 2310 0 R /Pg 36 0 R /Type /OBJR >> << /Obj 2309 0 R /Pg 36 0 R /Type /OBJR >> 8623 0 R 8624 0 R 8625 0 R 8626 0 R ] /P 8627 0 R /S /Link >> endobj %% Original object ID: 2028 0 4642 0 obj << /K [ << /Obj 2308 0 R /Pg 36 0 R /Type /OBJR >> 8611 0 R ] /P 6693 0 R /S /Link >> endobj %% Original object ID: 2029 0 4643 0 obj << /K [ << /Obj 2306 0 R /Pg 36 0 R /Type /OBJR >> 8577 0 R ] /P 6701 0 R /S /Link >> endobj %% Original object ID: 2030 0 4644 0 obj << /K [ << /Obj 2307 0 R /Pg 36 0 R /Type /OBJR >> 8581 0 R ] /P 6703 0 R /S /Link >> endobj %% Original object ID: 2031 0 4645 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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6720 0 R 8670 0 R 8671 0 R 8672 0 R 6717 0 R 8673 0 R 8674 0 R 6707 0 R 6708 0 R 6723 0 R 8675 0 R 6713 0 R 6714 0 R 6714 0 R 6714 0 R 6714 0 R 6714 0 R 6714 0 R 8676 0 R 6725 0 R 6725 0 R 8677 0 R 6726 0 R 8678 0 R 6727 0 R 8679 0 R 6728 0 R 6728 0 R 6728 0 R 6729 0 R 6729 0 R 8680 0 R 8681 0 R 8682 0 R ] endobj %% Original object ID: 2032 0 4646 0 obj << /K [ << /Obj 2316 0 R /Pg 37 0 R /Type /OBJR >> 2580 8644 0 R ] /P 6712 0 R /Pg 37 0 R /S /Link >> endobj %% Original object ID: 2033 0 4647 0 obj << /K [ << /Obj 2317 0 R /Pg 37 0 R /Type /OBJR >> 8645 0 R ] /P 6712 0 R /S /Link >> endobj %% Original object ID: 2034 0 4648 0 obj << /K [ << /Obj 2319 0 R /Pg 37 0 R /Type /OBJR >> 8674 0 R ] /P 6717 0 R /S /Link >> endobj %% Original object ID: 2035 0 4649 0 obj << /K [ << /Obj 2318 0 R /Pg 37 0 R /Type /OBJR >> 8671 0 R ] /P 6721 0 R /S /Link >> endobj %% Original object ID: 2036 0 4650 0 obj << /K [ << /Obj 2320 0 R /Pg 37 0 R /Type /OBJR >> 8675 0 R ] /P 6724 0 R /S /Link >> endobj %% Original object ID: 2037 0 4651 0 obj << /K [ << /Obj 2323 0 R /Pg 37 0 R /Type /OBJR >> << /Obj 2322 0 R /Pg 37 0 R /Type /OBJR >> << /Obj 2321 0 R /Pg 37 0 R /Type /OBJR >> 8680 0 R 8681 0 R 8682 0 R ] /P 6729 0 R /S /Link >> endobj %% Original object ID: 2038 0 4652 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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/Link >> endobj %% Original object ID: 2043 0 4657 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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8729 0 R /S /Link >> endobj %% Original object ID: 2046 0 4660 0 obj << /K [ << /Obj 2337 0 R /Pg 39 0 R /Type /OBJR >> 8716 0 R ] /P 6758 0 R /S /Link >> endobj %% Original object ID: 2047 0 4661 0 obj << /K [ << /Obj 2344 0 R /Pg 39 0 R /Type /OBJR >> 8740 0 R ] /P 6762 0 R /S /Link >> endobj %% Original object ID: 2048 0 4662 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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6781 0 R 6782 0 R 8776 0 R 6768 0 R 6769 0 R 6769 0 R ] endobj %% Original object ID: 2049 0 4663 0 obj << /K [ << /Obj 2349 0 R /Pg 40 0 R /Type /OBJR >> 8774 0 R ] /P 6775 0 R /S /Link >> endobj %% Original object ID: 2050 0 4664 0 obj << /K [ << /Obj 2350 0 R /Pg 40 0 R /Type /OBJR >> 8775 0 R ] /P 6779 0 R /S /Link >> endobj %% Original object ID: 2051 0 4665 0 obj << /K [ << /Obj 2351 0 R /Pg 40 0 R /Type /OBJR >> 8776 0 R ] /P 6783 0 R /S /Link >> endobj %% Original object ID: 2052 0 4666 0 obj << /K [ << /Obj 2348 0 R /Pg 40 0 R /Type /OBJR >> 8758 0 R ] /P 6790 0 R /S /Link >> endobj %% Original object ID: 2053 0 4667 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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null null null null null null null null null null null null null null null null null null null 6826 0 R 8777 0 R 8778 0 R 8778 0 R 8779 0 R 8780 0 R 8781 0 R 8782 0 R 8783 0 R 6796 0 R 8784 0 R 6812 0 R 6812 0 R 6801 0 R 8785 0 R 6802 0 R 6803 0 R 8786 0 R 6803 0 R 6804 0 R 6805 0 R 6806 0 R 6807 0 R 8787 0 R 8788 0 R 8789 0 R 8790 0 R 8788 0 R 8791 0 R 8792 0 R 4669 0 R 8793 0 R 4669 0 R 6809 0 R 6810 0 R 8794 0 R 6810 0 R 6825 0 R 6820 0 R 8795 0 R 6821 0 R 6822 0 R 8796 0 R 6823 0 R 8797 0 R 6824 0 R 6792 0 R 8798 0 R 8799 0 R 8800 0 R 8801 0 R 8802 0 R 8803 0 R 6814 0 R 8804 0 R 6816 0 R 6816 0 R 6816 0 R 6816 0 R 6816 0 R 6816 0 R 6816 0 R 6816 0 R 8805 0 R 6817 0 R 8806 0 R 6818 0 R 8807 0 R 8808 0 R 6818 0 R 8809 0 R 6819 0 R 6794 0 R 6795 0 R 8810 0 R 8811 0 R 8812 0 R 8812 0 R 8813 0 R 8814 0 R 8814 0 R 6797 0 R 6798 0 R 6799 0 R 6799 0 R 6799 0 R 6811 0 R 6811 0 R 6811 0 R 6811 0 R ] endobj %% Original object ID: 2054 0 4668 0 obj << /K [ << /Obj 2360 0 R /Pg 41 0 R /Type /OBJR >> 8810 0 R ] /P 6795 0 R /S /Link >> endobj %% Original object ID: 2055 0 4669 0 obj << /K [ << /Obj 2355 0 R /Pg 41 0 R /Type /OBJR >> 2920 8793 0 R 2922 ] /P 8792 0 R /Pg 41 0 R /S /Link >> endobj %% Original object ID: 2056 0 4670 0 obj << /K [ << /Obj 2357 0 R /Pg 41 0 R /Type /OBJR >> 8799 0 R ] /P 6813 0 R /S /Link >> endobj %% Original object ID: 2057 0 4671 0 obj << /K [ << /Obj 2358 0 R /Pg 41 0 R /Type /OBJR >> 8803 0 R ] /P 6814 0 R /S /Link >> endobj %% Original object ID: 2058 0 4672 0 obj << /K [ << /Obj 2359 0 R /Pg 41 0 R /Type /OBJR >> 8808 0 R ] /P 6818 0 R /S /Link >> endobj %% Original object ID: 2059 0 4673 0 obj << /K [ << /Obj 2356 0 R /Pg 41 0 R /Type /OBJR >> 8797 0 R ] /P 6824 0 R /S /Link >> endobj %% Original object ID: 2060 0 4674 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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8828 0 R 8828 0 R 8829 0 R 8828 0 R 8830 0 R 8831 0 R 8832 0 R 8832 0 R 8833 0 R 8832 0 R 8834 0 R 8832 0 R 8832 0 R 8835 0 R 8836 0 R 8832 0 R 8837 0 R 8838 0 R 8838 0 R 8839 0 R 8840 0 R 8841 0 R 8842 0 R 8843 0 R 8844 0 R 8845 0 R 8843 0 R 8846 0 R 8847 0 R 8848 0 R 8849 0 R 6841 0 R 8850 0 R 6842 0 R 8851 0 R 6843 0 R 6843 0 R 6843 0 R 8852 0 R 6844 0 R 6844 0 R 6844 0 R 8853 0 R 6845 0 R 6845 0 R 8854 0 R 8855 0 R 6845 0 R 8856 0 R 6846 0 R 6846 0 R 6846 0 R 6846 0 R 6846 0 R 6846 0 R 6846 0 R 6846 0 R 8857 0 R 6847 0 R 6847 0 R 6848 0 R 6835 0 R 6835 0 R 6835 0 R 6835 0 R 6835 0 R 6835 0 R 6835 0 R 6836 0 R 8858 0 R 8859 0 R 8860 0 R 8861 0 R 8861 0 R 8861 0 R 8862 0 R 8863 0 R 8864 0 R 8864 0 R 8864 0 R 8864 0 R 8864 0 R 8864 0 R 8864 0 R 8864 0 R 8864 0 R 8864 0 R 8864 0 R 8864 0 R 8864 0 R 8864 0 R 8864 0 R 8865 0 R 8866 0 R 8866 0 R ] endobj %% Original object ID: 2061 0 4675 0 obj << /K [ << /Obj 2365 0 R /Pg 42 0 R /Type /OBJR >> << /Obj 2364 0 R /Pg 42 0 R /Type /OBJR >> 8835 0 R 8836 0 R ] /P 8832 0 R /S /Link >> endobj %% Original object ID: 2062 0 4676 0 obj << /K [ << /Obj 2367 0 R /Pg 42 0 R /Type /OBJR >> << /Obj 2366 0 R /Pg 42 0 R /Type /OBJR >> 8840 0 R 8841 0 R ] /P 8838 0 R /S /Link >> endobj %% Original object ID: 2063 0 4677 0 obj << /K [ << /Obj 2368 0 R /Pg 42 0 R /Type /OBJR >> 8845 0 R ] /P 8843 0 R /S /Link >> endobj %% Original object ID: 2064 0 4678 0 obj << /K [ << /Obj 2373 0 R /Pg 42 0 R /Type /OBJR >> 8858 0 R ] /P 6837 0 R /S /Link >> endobj %% Original object ID: 2065 0 4679 0 obj << /K [ << /Obj 2374 0 R /Pg 42 0 R /Type /OBJR >> 8859 0 R ] /P 6839 0 R /S /Link >> endobj %% Original object ID: 2066 0 4680 0 obj << /K [ << /Obj 2369 0 R /Pg 42 0 R /Type /OBJR >> 8847 0 R ] /P 6840 0 R /S /Link >> endobj %% Original object ID: 2067 0 4681 0 obj << /K [ << /Obj 2370 0 R /Pg 42 0 R /Type /OBJR >> 8849 0 R ] /P 6841 0 R /S /Link >> endobj %% Original object ID: 2068 0 4682 0 obj << /K [ << /Obj 2372 0 R /Pg 42 0 R /Type /OBJR >> << /Obj 2371 0 R /Pg 42 0 R /Type /OBJR >> 8854 0 R 8855 0 R ] /P 6845 0 R /S /Link >> endobj %% Original object ID: 2069 0 4683 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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/S /Link >> endobj %% Original object ID: 2072 0 4686 0 obj << /K [ << /Obj 2379 0 R /Pg 43 0 R /Type /OBJR >> 8927 0 R ] /P 8925 0 R /S /Link >> endobj %% Original object ID: 2073 0 4687 0 obj << /K [ << /Obj 2378 0 R /Pg 43 0 R /Type /OBJR >> 8876 0 R ] /P 6856 0 R /S /Link >> endobj %% Original object ID: 2074 0 4688 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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<< /Obj 2389 0 R /Pg 44 0 R /Type /OBJR >> 3296 3297 3298 8979 0 R ] /P 8989 0 R /Pg 44 0 R /S /Link >> endobj %% Original object ID: 2079 0 4693 0 obj << /K [ << /Obj 2393 0 R /Pg 44 0 R /Type /OBJR >> 8987 0 R ] /P 6897 0 R /S /Link >> endobj %% Original object ID: 2080 0 4694 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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9031 0 R 9032 0 R 9033 0 R 9034 0 R 9034 0 R 9034 0 R 9035 0 R 9036 0 R 9037 0 R 9037 0 R 9037 0 R 9038 0 R 9039 0 R 6900 0 R 6900 0 R 9040 0 R 9041 0 R 9041 0 R 9041 0 R 9042 0 R 9043 0 R 9044 0 R 9045 0 R 9046 0 R 9047 0 R ] endobj %% Original object ID: 2081 0 4695 0 obj << /K [ << /Obj 2398 0 R /Type /OBJR >> << /Obj 2397 0 R /Pg 45 0 R /Type /OBJR >> 3331 3332 8990 0 R ] /P 6901 0 R /Pg 45 0 R /S /Link >> endobj %% Original object ID: 2082 0 4696 0 obj << /K [ << /Obj 2405 0 R /Pg 45 0 R /Type /OBJR >> << /Obj 2404 0 R /Pg 45 0 R /Type /OBJR >> << /Obj 2403 0 R /Pg 45 0 R /Type /OBJR >> << /Obj 2402 0 R /Pg 45 0 R /Type /OBJR >> 9044 0 R 9045 0 R 9046 0 R 9047 0 R ] /P 9048 0 R /S /Link >> endobj %% Original object ID: 2083 0 4697 0 obj << /K [ << /Obj 2401 0 R /Pg 45 0 R /Type /OBJR >> 9029 0 R 9030 0 R 9031 0 R ] /P 6922 0 R /S /Link >> endobj %% Original object ID: 2084 0 4698 0 obj << /K [ << /Obj 2399 0 R /Pg 45 0 R /Type /OBJR >> 8992 0 R ] /P 6930 0 R /S /Link >> endobj %% Original object ID: 2085 0 4699 0 obj << /K [ << /Obj 2400 0 R /Pg 45 0 R /Type /OBJR >> 8999 0 R ] /P 6933 0 R /S /Link >> endobj %% Original object ID: 2086 0 4700 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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6943 0 R 6943 0 R 6945 0 R 9084 0 R 9085 0 R 9086 0 R 9087 0 R 9088 0 R 9089 0 R 9090 0 R 9091 0 R 9092 0 R 9093 0 R 9094 0 R 9095 0 R 6948 0 R 9096 0 R 9097 0 R 9098 0 R 6950 0 R 9099 0 R 9100 0 R 6952 0 R 6952 0 R 9101 0 R 6953 0 R 6953 0 R 6953 0 R 6953 0 R 9102 0 R 6954 0 R 9103 0 R 6955 0 R 6955 0 R 9104 0 R 6956 0 R 6956 0 R 6956 0 R 6956 0 R 6951 0 R 6951 0 R 9105 0 R 9106 0 R 9107 0 R ] endobj %% Original object ID: 2087 0 4701 0 obj << /K [ << /Obj 2409 0 R /Pg 46 0 R /Type /OBJR >> 9067 0 R ] /P 6940 0 R /S /Link >> endobj %% Original object ID: 2088 0 4702 0 obj << /K [ << /Obj 2410 0 R /Pg 46 0 R /Type /OBJR >> 9070 0 R ] /P 6944 0 R /S /Link >> endobj %% Original object ID: 2089 0 4703 0 obj << /K [ << /Obj 2411 0 R /Pg 46 0 R /Type /OBJR >> 9097 0 R ] /P 6948 0 R /S /Link >> endobj %% Original object ID: 2090 0 4704 0 obj << /K [ << /Obj 2412 0 R /Pg 46 0 R /Type /OBJR >> 9099 0 R ] /P 6949 0 R /S /Link >> endobj %% Original object ID: 2091 0 4705 0 obj << /K [ << /Obj 2415 0 R /Pg 46 0 R /Type /OBJR >> << /Obj 2414 0 R /Pg 46 0 R /Type /OBJR >> << /Obj 2413 0 R /Pg 46 0 R /Type /OBJR >> 9105 0 R 9106 0 R 9107 0 R ] /P 6951 0 R /S /Link >> endobj %% Original object ID: 2092 0 4706 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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null null null null null null null null null null null null null 6973 0 R 6966 0 R 6966 0 R 9108 0 R 6966 0 R 6965 0 R 6965 0 R 6965 0 R 6965 0 R 6965 0 R 6965 0 R 6965 0 R 9109 0 R 9110 0 R 9111 0 R 9112 0 R 9113 0 R 9114 0 R 9115 0 R 9116 0 R 9117 0 R 9118 0 R 9119 0 R 9119 0 R 9119 0 R 9120 0 R 9121 0 R 6958 0 R 9122 0 R 9123 0 R 9124 0 R 6968 0 R 9125 0 R 6969 0 R 6969 0 R 9126 0 R 6970 0 R 9127 0 R 6971 0 R 9128 0 R 6972 0 R 6972 0 R 6972 0 R 6972 0 R 6960 0 R 6960 0 R 6960 0 R 6960 0 R 6960 0 R 9129 0 R 6960 0 R 6960 0 R 9130 0 R 6961 0 R 9131 0 R 6962 0 R 6962 0 R 6962 0 R 6962 0 R 6962 0 R 6963 0 R 6963 0 R 6963 0 R 6963 0 R 6967 0 R 6967 0 R 6967 0 R 9132 0 R 9133 0 R 9133 0 R 9133 0 R 9133 0 R 9133 0 R 9134 0 R 9135 0 R 9136 0 R 9136 0 R 9136 0 R 9136 0 R 9136 0 R 9137 0 R ] endobj %% Original object ID: 2093 0 4707 0 obj << /K [ << /Obj 2423 0 R /Pg 47 0 R /Type /OBJR >> << /Obj 2422 0 R /Pg 47 0 R /Type /OBJR >> << /Obj 2421 0 R /Pg 47 0 R /Type /OBJR >> << /Obj 2420 0 R /Pg 47 0 R /Type /OBJR >> 9114 0 R 9115 0 R 9116 0 R 9117 0 R ] /P 9138 0 R /S /Link >> endobj %% Original object ID: 2094 0 4708 0 obj << /K [ << /Obj 2425 0 R /Pg 47 0 R /Type /OBJR >> << /Obj 2424 0 R /Pg 47 0 R /Type /OBJR >> 9120 0 R 9121 0 R ] /P 9119 0 R /S /Link >> endobj %% Original object ID: 2095 0 4709 0 obj << /K [ << /Obj 2419 0 R /Pg 47 0 R /Type /OBJR >> 9111 0 R ] /P 6965 0 R /S /Link >> endobj %% Original object ID: 2096 0 4710 0 obj << /K [ << /Obj 2426 0 R /Pg 47 0 R /Type /OBJR >> 9124 0 R ] /P 6968 0 R /S /Link >> endobj %% Original object ID: 2097 0 4711 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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R 9143 0 R 9143 0 R 9144 0 R 9145 0 R 9146 0 R 9146 0 R 9146 0 R 9146 0 R 9147 0 R 9148 0 R 9149 0 R 9150 0 R 9151 0 R 9152 0 R 9153 0 R 9153 0 R 9153 0 R 9154 0 R 9155 0 R 9156 0 R 9157 0 R 9157 0 R 9157 0 R 9158 0 R 9159 0 R 9159 0 R 9159 0 R 9160 0 R 9161 0 R 9162 0 R 6988 0 R 9163 0 R 6989 0 R 6989 0 R 6989 0 R 6989 0 R 9164 0 R 6990 0 R 9165 0 R 6991 0 R 9166 0 R 9167 0 R 9168 0 R 9169 0 R 9169 0 R 9169 0 R 6980 0 R 6980 0 R 6980 0 R 9170 0 R 9171 0 R 9171 0 R 9172 0 R 9173 0 R 9173 0 R 9173 0 R 9173 0 R 9173 0 R 9173 0 R 9174 0 R 6975 0 R 6975 0 R 6975 0 R 6976 0 R 6977 0 R 6977 0 R 6977 0 R 6987 0 R ] endobj %% Original object ID: 2098 0 4712 0 obj << /K [ << /Obj 2434 0 R /Pg 48 0 R /Type /OBJR >> << /Obj 2433 0 R /Pg 48 0 R /Type /OBJR >> << /Obj 2432 0 R /Pg 48 0 R /Type /OBJR >> << /Obj 2431 0 R /Pg 48 0 R /Type /OBJR >> 9148 0 R 9149 0 R 9150 0 R 9151 0 R ] /P 9175 0 R /S /Link >> endobj %% Original object ID: 2099 0 4713 0 obj << /K [ << /Obj 2436 0 R /Pg 48 0 R /Type /OBJR >> << /Obj 2435 0 R /Pg 48 0 R /Type /OBJR >> 9154 0 R 9155 0 R ] /P 9153 0 R /S /Link >> endobj %% Original object ID: 2100 0 4714 0 obj << /K [ << /Obj 2430 0 R /Pg 48 0 R /Type /OBJR >> 9141 0 R ] /P 6984 0 R /S /Link >> endobj %% Original object ID: 2101 0 4715 0 obj << /K [ << /Obj 2437 0 R /Pg 48 0 R /Type /OBJR >> 9162 0 R ] /P 6988 0 R /S /Link >> endobj %% Original object ID: 2102 0 4716 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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null null null null null null null null null null null null null null null null null null 9176 0 R 7008 0 R 9177 0 R 7009 0 R 9178 0 R 9179 0 R 7010 0 R 9180 0 R 9181 0 R 9181 0 R 9181 0 R 9182 0 R 9183 0 R 9184 0 R 9183 0 R 9185 0 R 9186 0 R 9186 0 R 9186 0 R 9186 0 R 9186 0 R 9187 0 R 9188 0 R 9189 0 R 9189 0 R 9189 0 R 9189 0 R 9189 0 R 9189 0 R 9189 0 R 6994 0 R 7000 0 R 9190 0 R 9191 0 R 9192 0 R 9193 0 R 9193 0 R 9193 0 R 9193 0 R 9193 0 R 9193 0 R 9193 0 R 9193 0 R 9193 0 R 9193 0 R 7006 0 R 7007 0 R 9194 0 R 7005 0 R 7005 0 R 7005 0 R 7005 0 R 7005 0 R 6999 0 R 6999 0 R 9195 0 R 9196 0 R 7001 0 R 7001 0 R 9197 0 R 9198 0 R 7002 0 R 7003 0 R 7003 0 R 9199 0 R 9200 0 R 6995 0 R 7011 0 R 6993 0 R 6993 0 R ] endobj %% Original object ID: 2103 0 4717 0 obj << /K [ << /Obj 2442 0 R /Pg 49 0 R /Type /OBJR >> 9196 0 R ] /P 6999 0 R /S /Link >> endobj %% Original object ID: 2104 0 4718 0 obj << /K [ << /Obj 2443 0 R /Pg 49 0 R /Type /OBJR >> 9198 0 R ] /P 7001 0 R /S /Link >> endobj %% Original object ID: 2105 0 4719 0 obj << /K [ << /Obj 2444 0 R /Pg 49 0 R /Type /OBJR >> 9200 0 R ] /P 7003 0 R /S /Link >> endobj %% Original object ID: 2106 0 4720 0 obj << /K [ << /Obj 2441 0 R /Pg 49 0 R /Type /OBJR >> 9179 0 R ] /P 7010 0 R /S /Link >> endobj %% Original object ID: 2107 0 4721 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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9235 0 R 9236 0 R 9236 0 R 7018 0 R 9237 0 R 7019 0 R 7020 0 R 7020 0 R 7031 0 R 7031 0 R 7031 0 R 7031 0 R ] endobj %% Original object ID: 2108 0 4722 0 obj << /K [ << /Obj 2453 0 R /Pg 50 0 R /Type /OBJR >> 9232 0 R ] /P 7015 0 R /S /Link >> endobj %% Original object ID: 2109 0 4723 0 obj << /K [ << /Obj 2448 0 R /Pg 50 0 R /Type /OBJR >> 9217 0 R ] /P 9216 0 R /S /Link >> endobj %% Original object ID: 2110 0 4724 0 obj << /K [ << /Obj 2449 0 R /Pg 50 0 R /Type /OBJR >> 9220 0 R ] /P 7037 0 R /S /Link >> endobj %% Original object ID: 2111 0 4725 0 obj << /K [ << /Obj 2450 0 R /Pg 50 0 R /Type /OBJR >> 9222 0 R ] /P 7038 0 R /S /Link >> endobj %% Original object ID: 2112 0 4726 0 obj << /K [ << /Obj 2451 0 R /Pg 50 0 R /Type /OBJR >> 9225 0 R ] /P 7039 0 R /S /Link >> endobj %% Original object ID: 2113 0 4727 0 obj << /K [ << /Obj 2452 0 R /Pg 50 0 R /Type /OBJR >> 9229 0 R ] /P 7041 0 R /S /Link >> endobj %% Original object ID: 2114 0 4728 0 obj [ null null null null null null null 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0 R 9270 0 R 9271 0 R 7060 0 R 9272 0 R 7061 0 R 9273 0 R 7062 0 R 7062 0 R 7062 0 R 9274 0 R 7063 0 R 7063 0 R 7063 0 R 9275 0 R 7064 0 R 7064 0 R 9276 0 R 9277 0 R 7064 0 R 9278 0 R 7065 0 R 7065 0 R 7065 0 R 7065 0 R 7065 0 R 7065 0 R 7065 0 R 7065 0 R 9279 0 R 7066 0 R 7066 0 R 7054 0 R 7054 0 R 7054 0 R 7054 0 R 7054 0 R 7054 0 R 7054 0 R 7055 0 R 9280 0 R 9281 0 R 9282 0 R 9283 0 R 9283 0 R 9284 0 R 9285 0 R 9286 0 R 9286 0 R 9286 0 R 9286 0 R 9286 0 R 9286 0 R 9286 0 R 9286 0 R 9286 0 R 9286 0 R 9286 0 R 9286 0 R 9286 0 R 9287 0 R 9288 0 R ] endobj %% Original object ID: 2115 0 4729 0 obj << /K [ << /Obj 2458 0 R /Pg 51 0 R /Type /OBJR >> << /Obj 2457 0 R /Pg 51 0 R /Type /OBJR >> 9257 0 R 9258 0 R ] /P 9254 0 R /S /Link >> endobj %% Original object ID: 2116 0 4730 0 obj << /K [ << /Obj 2459 0 R /Pg 51 0 R /Type /OBJR >> 9262 0 R ] /P 9260 0 R /S /Link >> endobj %% Original object ID: 2117 0 4731 0 obj << /K [ << /Obj 2460 0 R /Pg 51 0 R /Type /OBJR >> 9266 0 R ] /P 9264 0 R /S /Link >> endobj %% Original object ID: 2118 0 4732 0 obj << /K [ << /Obj 2465 0 R /Pg 51 0 R /Type /OBJR >> 9280 0 R ] /P 7056 0 R /S /Link >> endobj %% Original object ID: 2119 0 4733 0 obj << /K [ << /Obj 2466 0 R /Pg 51 0 R /Type /OBJR >> 9281 0 R ] /P 7057 0 R /S /Link >> endobj %% Original object ID: 2120 0 4734 0 obj << /K [ << /Obj 2461 0 R /Pg 51 0 R /Type /OBJR >> 9268 0 R ] /P 7059 0 R /S /Link >> endobj %% Original object ID: 2121 0 4735 0 obj << /K [ << /Obj 2462 0 R /Pg 51 0 R /Type /OBJR >> 9271 0 R ] /P 7060 0 R /S /Link >> endobj %% Original object ID: 2122 0 4736 0 obj << /K [ << /Obj 2464 0 R /Pg 51 0 R /Type /OBJR >> << /Obj 2463 0 R /Pg 51 0 R /Type /OBJR >> 9276 0 R 9277 0 R ] /P 7064 0 R /S /Link >> endobj %% Original object ID: 2123 0 4737 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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9301 0 R 9302 0 R 9303 0 R 9304 0 R 9305 0 R 9306 0 R 9307 0 R 9308 0 R 9309 0 R 9310 0 R 9311 0 R 9312 0 R 9313 0 R 9314 0 R 9315 0 R 9316 0 R 9317 0 R 9318 0 R 9319 0 R 9320 0 R 9321 0 R 9322 0 R 9323 0 R 9324 0 R 9325 0 R 9324 0 R 9326 0 R 9327 0 R 9327 0 R 9328 0 R 9327 0 R 9329 0 R 9330 0 R 9331 0 R 9332 0 R 9333 0 R 9334 0 R 9332 0 R 9335 0 R 9336 0 R 9336 0 R 9336 0 R 9337 0 R 9338 0 R 9338 0 R 9338 0 R 9339 0 R 9340 0 R 9341 0 R 9340 0 R 9342 0 R 9343 0 R 9343 0 R 9344 0 R 9345 0 R 9346 0 R 9347 0 R 9348 0 R 9346 0 R 9349 0 R 9350 0 R 9351 0 R 9350 0 R 9350 0 R 9350 0 R 9352 0 R 9353 0 R 9353 0 R 9354 0 R 9355 0 R 9356 0 R 9357 0 R 9358 0 R 9359 0 R 9360 0 R 9361 0 R 9362 0 R 9363 0 R 9364 0 R 9365 0 R 9366 0 R 9367 0 R 9367 0 R 9367 0 R 9368 0 R 9369 0 R 9369 0 R 9369 0 R 9370 0 R 9371 0 R 9372 0 R 9373 0 R 9373 0 R 9374 0 R 9375 0 R 9376 0 R 9377 0 R 9378 0 R 9376 0 R 7070 0 R ] endobj %% Original object ID: 2124 0 4738 0 obj << /K [ << /Obj 2472 0 R /Pg 52 0 R /Type /OBJR >> 9360 0 R ] /P 9358 0 R /S /Link >> endobj %% Original object ID: 2125 0 4739 0 obj << /K [ << /Obj 2473 0 R /Pg 52 0 R /Type /OBJR >> 9378 0 R ] /P 9376 0 R /S /Link >> endobj %% Original object ID: 2126 0 4740 0 obj << /K [ << /Obj 2471 0 R /Pg 52 0 R /Type /OBJR >> 9348 0 R ] /P 9346 0 R /S /Link >> endobj %% Original object ID: 2127 0 4741 0 obj << /K [ << /Obj 2470 0 R /Pg 52 0 R /Type /OBJR >> 9298 0 R ] /P 7075 0 R /S /Link >> endobj %% Original object ID: 2128 0 4742 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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/Type /OBJR >> << /Obj 2493 0 R /Type /OBJR >> << /Obj 2492 0 R /Pg 54 0 R /Type /OBJR >> 4291 4292 9446 0 R ] /P 7113 0 R /Pg 54 0 R /S /Link >> endobj %% Original object ID: 2135 0 4749 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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9461 0 R 9462 0 R 9462 0 R 9462 0 R 9463 0 R 9462 0 R 9462 0 R 9464 0 R 9465 0 R 9466 0 R 9467 0 R 9468 0 R 9469 0 R 9470 0 R 9471 0 R 9472 0 R 9473 0 R 9474 0 R 9475 0 R 9476 0 R 9477 0 R 9477 0 R 9478 0 R 9477 0 R 9479 0 R 9480 0 R 9481 0 R 9482 0 R 9482 0 R 9483 0 R 9484 0 R 9485 0 R 9485 0 R 9485 0 R 9486 0 R 9487 0 R 9487 0 R 9488 0 R 9489 0 R 9489 0 R 4750 0 R 4750 0 R 4750 0 R 4750 0 R 9490 0 R 9491 0 R 9492 0 R 9493 0 R 9494 0 R 7133 0 R 9495 0 R 7134 0 R 9496 0 R 7135 0 R 9497 0 R 7136 0 R 7136 0 R 7136 0 R 7136 0 R 7136 0 R 7136 0 R 7136 0 R 7136 0 R 7136 0 R 7136 0 R 9498 0 R 7137 0 R 9499 0 R 7138 0 R 7138 0 R 9500 0 R 7139 0 R ] endobj %% Original object ID: 2136 0 4750 0 obj << /K [ << /Obj 2502 0 R /Type /OBJR >> << /Obj 2501 0 R /Type /OBJR >> << /Obj 2500 0 R /Type /OBJR >> << /Obj 2499 0 R /Type /OBJR >> << /Obj 2498 0 R /Pg 55 0 R /Type /OBJR >> 4375 4376 4377 4378 9490 0 R ] /P 7124 0 R /Pg 55 0 R /S /Link >> endobj %% Original object ID: 2137 0 4751 0 obj << /K [ << /Obj 2505 0 R /Pg 55 0 R /Type /OBJR >> << /Obj 2504 0 R /Pg 55 0 R /Type /OBJR >> << /Obj 2503 0 R /Pg 55 0 R /Type /OBJR >> 9491 0 R 9492 0 R 9493 0 R ] /P 7132 0 R /S /Link >> endobj %% Original object ID: 2138 0 4752 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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0 4753 0 obj << /K [ << /Obj 2513 0 R /Type /OBJR >> << /Obj 2512 0 R /Type /OBJR >> << /Obj 2511 0 R /Type /OBJR >> << /Obj 2510 0 R /Type /OBJR >> << /Obj 2509 0 R /Pg 56 0 R /Type /OBJR >> 4444 4445 4446 4447 9517 0 R ] /P 7144 0 R /Pg 56 0 R /S /Link >> endobj %% Original object ID: 2140 0 4754 0 obj << /K [ << /Obj 2518 0 R /Type /OBJR >> << /Obj 2517 0 R /Type /OBJR >> << /Obj 2516 0 R /Type /OBJR >> << /Obj 2515 0 R /Type /OBJR >> << /Obj 2514 0 R /Pg 56 0 R /Type /OBJR >> 4461 4462 4463 4464 9528 0 R ] /P 7153 0 R /Pg 56 0 R /S /Link >> endobj %% Original object ID: 2141 0 4755 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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null null null null 7196 0 R 7160 0 R 7160 0 R 7161 0 R 9533 0 R 9534 0 R 9535 0 R 9535 0 R 9536 0 R 9537 0 R 7166 0 R 7166 0 R 7166 0 R 7167 0 R 7168 0 R 7169 0 R 7185 0 R 7185 0 R 7185 0 R 7186 0 R 7187 0 R 7187 0 R 7187 0 R 9538 0 R 9539 0 R 9540 0 R 9541 0 R 9542 0 R 9542 0 R 9542 0 R 9542 0 R 9543 0 R 9544 0 R 9544 0 R 9544 0 R 9544 0 R 9544 0 R 9544 0 R 7188 0 R 7162 0 R 7162 0 R 7162 0 R 7162 0 R 7173 0 R 7173 0 R 7173 0 R 9545 0 R 9546 0 R 9546 0 R 9547 0 R 9548 0 R 9548 0 R 9548 0 R 9549 0 R 9550 0 R 9550 0 R 9550 0 R 9550 0 R 9551 0 R 9552 0 R 9552 0 R 9553 0 R 9554 0 R 9555 0 R 9556 0 R 9557 0 R 9556 0 R 9558 0 R 9559 0 R 9559 0 R 9559 0 R 9560 0 R 9561 0 R 9561 0 R 9562 0 R 9563 0 R 9563 0 R 9563 0 R 9563 0 R 9564 0 R 7171 0 R 7172 0 R 7177 0 R 7178 0 R 7183 0 R 7184 0 R 7191 0 R 7192 0 R 7164 0 R 7164 0 R 9565 0 R 9566 0 R 9567 0 R 9568 0 R 9569 0 R 7174 0 R 7174 0 R 7175 0 R 7176 0 R 7176 0 R 7176 0 R 7176 0 R 7181 0 R 7181 0 R 9570 0 R 9571 0 R 9572 0 R 9573 0 R 9574 0 R 7189 0 R 7190 0 R 7190 0 R 9575 0 R 7193 0 R 9576 0 R 9577 0 R 7194 0 R 9578 0 R 9579 0 R 7195 0 R 9580 0 R 7195 0 R ] endobj %% Original object ID: 2142 0 4756 0 obj << /K [ << /Obj 2522 0 R /Pg 57 0 R /Type /OBJR >> 9566 0 R ] /P 7165 0 R /S /Link >> endobj %% Original object ID: 2143 0 4757 0 obj << /K [ << /Obj 2523 0 R /Pg 57 0 R /Type /OBJR >> 9568 0 R ] /P 7165 0 R /S /Link >> endobj %% Original object ID: 2146 0 4758 0 obj << /K [ << /Obj 2524 0 R /Pg 57 0 R /Type /OBJR >> 9571 0 R ] /P 7181 0 R /S /Link >> endobj %% Original object ID: 2149 0 4759 0 obj << /K [ << /Obj 2525 0 R /Pg 57 0 R /Type /OBJR >> 9573 0 R ] /P 7182 0 R /S /Link >> endobj %% Original object ID: 2152 0 4760 0 obj << /K [ << /Obj 2526 0 R /Pg 57 0 R /Type /OBJR >> 9577 0 R ] /P 7194 0 R /S /Link >> endobj %% Original object ID: 2155 0 4761 0 obj << /K [ << /Obj 2527 0 R /Pg 57 0 R /Type /OBJR >> 9580 0 R ] /P 7195 0 R /S /Link >> endobj %% Original object ID: 2158 0 4762 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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null 7210 0 R 7197 0 R 7198 0 R 7204 0 R 7201 0 R 7201 0 R 7202 0 R 9581 0 R 9582 0 R 9583 0 R 9584 0 R 7205 0 R 9585 0 R 7206 0 R 7206 0 R 9586 0 R 7207 0 R 7207 0 R 7207 0 R 9587 0 R 7208 0 R 9588 0 R 9589 0 R 4764 0 R 9590 0 R 7209 0 R 7199 0 R 9591 0 R 9592 0 R 9593 0 R 9594 0 R 9594 0 R 9595 0 R 9596 0 R 9597 0 R 9596 0 R 9596 0 R 9598 0 R 9599 0 R 9600 0 R 9601 0 R 9602 0 R 9603 0 R 9604 0 R 9603 0 R 9605 0 R 9606 0 R 9607 0 R 9608 0 R 9609 0 R 9610 0 R 9610 0 R 9610 0 R 9611 0 R 9610 0 R 9612 0 R 9613 0 R 9614 0 R 9615 0 R 9616 0 R 9617 0 R 9618 0 R 9619 0 R ] endobj %% Original object ID: 2211 0 4763 0 obj << /K [ << /Obj 2531 0 R /Pg 58 0 R /Type /OBJR >> 9582 0 R ] /P 7203 0 R /S /Link >> endobj %% Original object ID: 2178 0 4764 0 obj << /K [ << /Obj 2533 0 R /Pg 58 0 R /Type /OBJR >> << /Obj 2532 0 R /Pg 58 0 R /Type /OBJR >> 9588 0 R 9589 0 R 4629 ] /P 7208 0 R /Pg 58 0 R /S /Link >> endobj %% Original object ID: 2213 0 4765 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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7239 0 R 9745 0 R 9746 0 R 9747 0 R 9747 0 R 9747 0 R 9747 0 R 9748 0 R 9749 0 R 9750 0 R 9751 0 R 9751 0 R 9751 0 R 9752 0 R 9753 0 R 9753 0 R 9754 0 R 7260 0 R 7260 0 R 9755 0 R 7261 0 R 7261 0 R 7261 0 R 7261 0 R 7261 0 R 9756 0 R 7262 0 R 7262 0 R 9757 0 R 9758 0 R 7263 0 R 9759 0 R 7264 0 R 7264 0 R 9760 0 R 7264 0 R 9761 0 R 9762 0 R 7265 0 R 7236 0 R 9763 0 R 7237 0 R 7237 0 R 9764 0 R 7238 0 R 7238 0 R 7238 0 R 7238 0 R 7238 0 R 7238 0 R 7250 0 R 9765 0 R 7250 0 R 7240 0 R 7240 0 R 7241 0 R 7241 0 R 7242 0 R 9766 0 R 7242 0 R 7242 0 R 7242 0 R 7249 0 R 7249 0 R 7249 0 R 9767 0 R 7249 0 R 7249 0 R 7248 0 R 7248 0 R 7248 0 R 7248 0 R 7248 0 R 7248 0 R 7248 0 R 7248 0 R 7257 0 R 7258 0 R 7258 0 R 9768 0 R 9769 0 R 7267 0 R 7245 0 R 9770 0 R 7245 0 R 9771 0 R 7246 0 R 7246 0 R 7243 0 R 7243 0 R 7243 0 R 7243 0 R 7243 0 R 7244 0 R 7252 0 R 9772 0 R 9773 0 R 9774 0 R 9775 0 R 9776 0 R ] endobj %% Original object ID: 2416 0 4768 0 obj << /K [ << /Obj 2545 0 R /Pg 60 0 R /Type /OBJR >> 9769 0 R ] /P 7259 0 R /S /Link >> endobj %% Original object ID: 2418 0 4769 0 obj << /K [ << /Obj 2542 0 R /Pg 60 0 R /Type /OBJR >> 9758 0 R ] /P 7263 0 R /S /Link >> endobj %% Original object ID: 2419 0 4770 0 obj << /K [ << /Obj 2543 0 R /Pg 60 0 R /Type /OBJR >> 9760 0 R ] /P 7264 0 R /S /Link >> endobj %% Original object ID: 2420 0 4771 0 obj << /K [ << /Obj 2544 0 R /Pg 60 0 R /Type /OBJR >> 9762 0 R ] /P 7265 0 R /S /Link >> endobj %% Original object ID: 2421 0 4772 0 obj << /K [ << /Obj 2549 0 R /Pg 60 0 R /Type /OBJR >> << /Obj 2548 0 R /Pg 60 0 R /Type /OBJR >> << /Obj 2547 0 R /Pg 60 0 R /Type /OBJR >> << /Obj 2546 0 R /Pg 60 0 R /Type /OBJR >> 9773 0 R 9774 0 R 9775 0 R 9776 0 R ] /P 7266 0 R /S /Link >> endobj %% Original object ID: 2423 0 4773 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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7280 0 R 7280 0 R 7280 0 R 7280 0 R 7280 0 R 7280 0 R 7280 0 R 7280 0 R 9809 0 R 7281 0 R 7281 0 R 9810 0 R 9811 0 R 9812 0 R 7282 0 R 7270 0 R 9813 0 R 9814 0 R 9814 0 R 9814 0 R 9814 0 R 9814 0 R 9814 0 R 9815 0 R 9816 0 R 9816 0 R 9817 0 R 9818 0 R 9818 0 R 9819 0 R 9820 0 R 9820 0 R 9821 0 R 9822 0 R 9822 0 R 9823 0 R 9822 0 R 9824 0 R 9825 0 R 9825 0 R 9826 0 R 9825 0 R 9827 0 R 9828 0 R 9829 0 R 9830 0 R 9831 0 R 7269 0 R ] endobj %% Original object ID: 2437 0 4774 0 obj << /K [ << /Obj 2553 0 R /Pg 61 0 R /Type /OBJR >> 4953 9785 0 R 4955 ] /P 9783 0 R /Pg 61 0 R /S /Link >> endobj %% Original object ID: 2492 0 4775 0 obj << /K [ << /Obj 2560 0 R /Pg 61 0 R /Type /OBJR >> << /Obj 2559 0 R /Pg 61 0 R /Type /OBJR >> 9828 0 R 9829 0 R ] /P 9832 0 R /S /Link >> endobj %% Original object ID: 2494 0 4776 0 obj << /K [ << /Obj 2556 0 R /Pg 61 0 R /Type /OBJR >> << /Obj 2555 0 R /Pg 61 0 R /Type /OBJR >> << /Obj 2554 0 R /Pg 61 0 R /Type /OBJR >> 9799 0 R 9800 0 R 9801 0 R ] /P 9833 0 R /S /Link >> endobj %% Original object ID: 2496 0 4777 0 obj << /K [ << /Obj 2557 0 R /Pg 61 0 R /Type /OBJR >> 9806 0 R ] /P 7279 0 R /S /Link >> endobj %% Original object ID: 2497 0 4778 0 obj << /K [ << /Obj 2558 0 R /Pg 61 0 R /Type /OBJR >> 9812 0 R ] /P 7282 0 R /S /Link >> endobj %% Original object ID: 2498 0 4779 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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0 R 7286 0 R 7284 0 R ] endobj %% Original object ID: 2540 0 4780 0 obj << /K [ << /Obj 2564 0 R /Pg 62 0 R /Type /OBJR >> 9869 0 R ] /P 7286 0 R /S /Link >> endobj %% Original object ID: 2541 0 4781 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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10015 0 R 10016 0 R 10017 0 R 10018 0 R 10018 0 R 10018 0 R 10018 0 R 10019 0 R 10020 0 R 10020 0 R 10021 0 R 10022 0 R ] endobj %% Original object ID: 2730 0 4787 0 obj << /K [ << /Obj 2581 0 R /Pg 67 0 R /Type /OBJR >> 10007 0 R ] /P 10006 0 R /S /Link >> endobj %% Original object ID: 2731 0 4788 0 obj << /K [ << /Obj 2582 0 R /Pg 67 0 R /Type /OBJR >> 10008 0 R ] /P 10006 0 R /S /Link >> endobj %% Original object ID: 2732 0 4789 0 obj << /K [ << /Obj 2583 0 R /Pg 67 0 R /Type /OBJR >> 10021 0 R ] /P 7335 0 R /S /Link >> endobj %% Original object ID: 2734 0 4790 0 obj << /K [ << /Obj 2584 0 R /Pg 67 0 R /Type /OBJR >> 10022 0 R ] /P 7336 0 R /S /Link >> endobj %% Original object ID: 2736 0 4791 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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/OBJR >> 10127 0 R ] /P 7359 0 R /S /Link >> endobj %% Original object ID: 2860 0 4797 0 obj [ null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null 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~‹™§1µ ć    . J f b‚© 2017 The Monotype Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. This layout logic for Biblical Hebrew is open source software under the MIT License; see embedded license description for details.Arial is a trademark of The Monotype Corporation.© 2017 The Monotype Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. This layout logic for Biblical Hebrew is open source software under the MIT License; see embedded license description for details.PTSIAU+ArialMTPTSIAU+ArialMTPTSIAU+ArialMTArial is a trademark of The Monotype Corporation.© 2017 The Monotype Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. 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" # $ % & ' ( ) * Î Ď Đ Ń Ň Ó Ô Ő Ö × Ř Ůčéęë ű˛ŠĹ4µ¶Ăĺł´Ä Ć‚Á‡NORPQ ×ĹŤŽ Ç5GćUVWXSTcľżaŔÁb ţ ˙ őç  7  Ŕ~Ľ      Î Ď Đ ŃIJ _ `“…†dŚc‹ Ú™íÂĄ’?ŹAv‘’“w¸|    ! " # $ % & ' ( ) Idef J K L * + , -ghijklmn . / 0 1 Q R S T U 2 3 V M N O Püýţ˙     d‡żŔ‰Š‹tuwĆ ą ş » Ľ ˝ ľ ż Ŕ ÁÇČÉĘËĚÍÎĎĐŃŇÓŢßŕáâăäĺćç<=RSTU !"bcdeNOPQ^_`aJKLMĂÄĹĆËĚÍÎrstunopq'()*z{|}‰†‡Š‹~+,‘-./01234óôőöëěíîLMjklëęëě@ABC‰-Š.‹/Ś0Ť2ŽŹ1‘’ßŕáâ()&'*+F01$%,-:;<=))”•–—™š›śťžź ˇ˘Ł¤Ą56óôGHIJK Wxy|} Í!€‚„…†‡®d ~‹ž±1Ä ő & 9 &G &m &“ bą© 2017 The Monotype Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. This layout logic for Biblical Hebrew is open source software under the MIT License; see embedded license description for details.Arial is a trademark of The Monotype Corporation.© 2017 The Monotype Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. This layout logic for Biblical Hebrew is open source software under the MIT License; see embedded license description for details.UTQPCK+Arial-BoldMTUTQPCK+Arial-BoldMTUTQPCK+Arial-BoldMTArial is a trademark of The Monotype Corporation.© 2017 The Monotype Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. 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All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. This layout logic for Biblical Hebrew is open source software under the MIT License; see embedded license description for details.Arial is a trademark of The Monotype Corporation.© 2017 The Monotype Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. This layout logic for Biblical Hebrew is open source software under the MIT License; see embedded license description for details.YHCFWC+Arial-BoldItalicMTYHCFWC+Arial-BoldItalicMTYHCFWC+Arial-BoldItalicMTArial is a trademark of The Monotype Corporation.© 2017 The Monotype Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. 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All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. This layout logic for Biblical Hebrew is open source software under the MIT License; see embedded license description for details.Arial is a trademark of The Monotype Corporation.© 2017 The Monotype Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. This layout logic for Biblical Hebrew is open source software under the MIT License; see embedded license description for details.EYXPCQ+Arial-ItalicMTEYXPCQ+Arial-ItalicMTEYXPCQ+Arial-ItalicMTArial is a trademark of The Monotype Corporation.© 2017 The Monotype Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. 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řá®v†Žˇ´;Ç  & : &H &n &” vş© 2018 Microsoft Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. This layout logic for Biblical Hebrew is open source software under the MIT License; see embedded license description for details.Calibri is a trademark of the Microsoft group of companies.© 2018 Microsoft Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. This layout logic for Biblical Hebrew is open source software under the MIT License; see embedded license description for details.QHXARR+Calibri-BoldQHXARR+Calibri-BoldQHXARR+Calibri-BoldCalibri is a trademark of the Microsoft group of companies.© 2018 Microsoft Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. 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All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. This layout logic for Biblical Hebrew is open source software under the MIT License; see embedded license description for details.Calibri is a trademark of the Microsoft group of companies.© 2018 Microsoft Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. This layout logic for Biblical Hebrew is open source software under the MIT License; see embedded license description for details.HRHYVJ+CalibriHRHYVJ+CalibriHRHYVJ+CalibriCalibri is a trademark of the Microsoft group of companies.© 2018 Microsoft Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. This layout logic for Biblical Hebrew is open source software under the MIT License; see embedded license description for details.HRHYVJ+CalibriRegularHRHYVJ+CalibriHRHYVJ+CalibriHRHYVJ+CalibriCalibri is a trademark of the Microsoft group of companies.˙†± ASČĆ8ÇĆ8Ý8ÚUŮ8×UŘ8×UÖ8ŐUÔ8ÓUŇ8ŃUż8ľU˝8ĽUŰ4ŰTŰ4ŰTŰdۤŰÔŰkŐ ŃÂDÂdÂt”¤ľ¤Ľ „´ J ¸´ J ¸‚´ J ¸´ J ¸€´ J ¸´ J ¸~´ J ¸}´ J ¸|´ J ¸{´ J ¸z´ J ¸y´ J ¸x´ J ¸w´ J ¸v´ J ¸u´ J ¸t´ J ¸s´ J ¸q´ J ¸p´ J ¸o´ J ¸n´ J ¸m´ J ¸l´ J ¸k´ J ¸j´ J ¸i´ J ¸h´ J ¸g´ J ¸f´ J ¸e´ J ¸d´ J ¸c´ J ¸b´ J ¸a´ J ¸`´ J ¸_´ J ¸^´ J ¸]´ J ¸\´ J ¸[´ J ¸Z´ J ¸Y´ J ¸X´ J ¸W´ J ¸V´ J ¸U´ J ¸T´ J ¸S´ J ¸R´ J ¸Q´ J ¸P´ J ¸O´ J ¸N´ J ¸M´ J ¸L´ J ¸K´ J ¸J´ J ¸I´ J ¸H´ J ¸G´ J ¸F´ J ¸E´ J ¸D´ J ¸C´ J ¸B´ J ¸A´ J ¸@´ J ¸?´ J ¸>´ J ¸=´ J ¸<´ J ¸;´ J ¸:´ J ¸9´ J ¸8´ J ¸7´ J ¸6´ J ¸5´ J ¸4´ J ¸3´ J ¸2´ J ¸1´ J ¸0´ J ¸/´ J ¸.´ J ¸-´ J ¸,´ J ¸+´ J ¸*´ J ¸)´ J ¸(´ J ¸'´ J ¸&´ J ¸%´ J ¸$´ J ¸#´ J ¸"´ J ¸!´ J ¸ ´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸ ´ J ¸ ´ J ¸ ´ J ¸ ´ J ¸ ´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸´ J ¸˙´ J ¸ţ´ J ¸ý´ J ¸ü´ J ¸ű´ J ¸ú´ J ¸ů´ J ¸ř´ J ¸÷´ J ¸ö´ J ¸ő´ J ¸ô´ J ¸ó´ J ¸ň´ J ¸ń´ J ¸đ´ J ¸ď´ J ¸î´ J ¸í´ J ¸ě´ J ¸ë´ J ¸ę´ J ¸é´ J ¸č´ J ¸ç´ J ¸ć´ J ¸ĺ´ J ¸ä´ J ¸ă´ J ¸â´ J ¸á´ J ¸ŕ´ J ¸ß´ J ¸Ţ´ J ¸Ý´ J ¸Ü´ J ¸Ű´ J ¸Ú´ J ¸Ů´ J ¸Ř´ J ¸×´ J ¸Ö´ J ¸Ő´ J ¸Ô´ J ¸Ó´ J ¸Ň´ J ¸Ń´ J ¸Đ´ J ¸Ď´ J ¸δ J ¸Í´ J ¸Ě´ J ¸Ë´ J ¸Ę´ J ¸É´ J ¸Č´ J ¸Ç´ J ¸Ć´ J ¸Ĺ´ J ¸Ä´ J ¸Ă´ J ¸´ J ¸Á´ J ¸Ŕ´ J ¸ż´ J ¸ľ´ J ¸˝´ J ¸Ľ´ J ¸»´ J ¸ş´ J ¸ą´ J ¸¸´ J ¸·´ J ¸¶´ J ¸µ´ J ¸´´ J ¸ł´ J ¸˛´ J ¸±´ J ¸°´ J ¸Ż´ J ¸®´ J ¸­´ J ¸¬´ J ¸«´ J ¸Ş´ J ¸©´ J ¸¨´ J ¸§´ J ¸¦´ J ¸Ą´ J ¸¤´ J ¸Ł´ J ¸˘´ J ¸ˇ´ J ¸ ´ J ¸ź´ J ¸ž´ J ¸ť´ J ¸ś´ J ¸›´ J ¸š´ J ¸™´ J ¸´ J ¸—´ J ¸–´ J ¸•´ J ¸”´ J ¸“´ J ¸’´ J ¸‘´ J ¸´ J ¸Ź´ J ¸Ž´ J ¸Ť´ J ¸Ś´ J ¸‹´ J ¸Š´ J ¸‰´ J ¸´ J ¸‡´ J ¸†´ J ¸…´ J ¸„´ J ¸´ J ¸‚´ J ¸´ J ¸€´ J ¸´ J ¸~´ J ¸}´ J ¸|´ J ¸{´ J ¸z´ J ¸y´ J ¸x´ J ¸w´ J ¸v´ J ¸u´ J ¸t´ J ¸s´ J ¸r´ J ¸q´ J ¸p´ J ¸o´ J ¸n´ J ¸m´ J ¸l´ J ¸k´ J ¸j´ J ¸i´ J ¸h´ J ¸g´ J ¸f´ J ¸e´ J ¸d´ J ¸c´ J ¸b´ J ¸a´ J ¸`´ J ¸_´ J ¸^´ J ¸]´ J ¸\´ J ¸[´ J ¸Z´ J ¸Y´ J ¸X´ J ¸W´ J ¸V´ J ¸U´ J ¸T´ J ¸S´ J ¸R´ J ¸P´ J ¸O´ J ¸N´ J ¸L´ J ¸K´ J ¸J´ J ¸I´ J ¸H´ J ¸G´ J ¸F´ J ¸E´ J ¸D´ J ¸Cł J¸„˛>¸˛¸‚˛>¸˛:¸€˛>¸˛>¸~˛ ¸}˛>¸|˛>¸{˛>¸z˛>¸y˛A¸x˛C¸w˛C¸v˛C¸u˛A¸t˛C¸s˛C¸r˛A¸q˛B¸p˛B¸o˛B¸n˛C¸m˛C¸l˛C¸k˛E¸j˛E¸i˛E¸h˛E¸g˛E¸f˛D¸e˛E¸d˛E¸c˛E¸b˛E¸a˛E¸`˛E¸_˛E¸^˛D¸]˛E¸\˛E¸[˛E¸Z˛E¸Y˛E¸X˛E¸W˛E¸V˛E¸U˛E¸T˛E¸S˛E¸R˛E¸Q˛E¸P˛E¸O˛E¸N˛E¸M˛E¸L˛E¸K˛E¸J˛I¸I˛I¸H˛J¸G˛J¸F˛K¸E˛L¸D˛L¸C˛L¸B˛K¸A˛I¸@˛I¸?˛J¸>˛J¸=˛J¸<˛K¸;˛K¸:˛L¸9˛L¸8˛L¸7˛L¸6˛L¸5˛I¸4˛I¸3˛J¸2˛J¸1˛J¸0˛K¸/˛K¸.˛L¸-˛L¸,˛L¸+˛L¸*˛L¸)˛L¸(˛L¸'˛I¸&˛I¸%˛J¸$˛J¸#˛J¸"˛K¸!˛K¸ ˛L¸˛L¸˛L¸˛L¸˛L¸˛L¸˛N¸˛N¸˛O¸˛O¸˛N¸˛N¸˛O¸˛O¸˛O¸˛N¸˛N¸˛O¸˛O¸ ˛O¸ ˛N¸ ˛N¸ ˛N¸ 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All rights reserved.Cambria is a trademark of the Microsoft group of companies.© 2017 Microsoft Corporation. All rights reserved.VHGZJH+CambriaVHGZJH+CambriaVHGZJH+CambriaCambria is a trademark of the Microsoft group of companies.© 2017 Microsoft Corporation. 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endobj %% Original object ID: 8209 0 10648 0 obj << /C /Pa9 /K [ 11249 0 R 8123 0 R ] /P 6410 0 R /S /LI >> endobj %% Original object ID: 8210 0 10649 0 obj << /C /Pa9 /K [ 11250 0 R 8125 0 R ] /P 6410 0 R /S /LI >> endobj %% Original object ID: 8211 0 10650 0 obj << /C /Pa9 /K [ 11251 0 R 8127 0 R ] /P 6410 0 R /S /LI >> endobj %% Original object ID: 8199 0 10651 0 obj << /C /Pa9 /K [ 11257 0 R 8141 0 R ] /P 6412 0 R /S /LI >> endobj %% Original object ID: 8188 0 10652 0 obj << /C /Pa9 /K [ 11242 0 R 8107 0 R ] /P 6419 0 R /S /LI >> endobj %% Original object ID: 8189 0 10653 0 obj << /C /Pa9 /K [ 11243 0 R 8109 0 R ] /P 6419 0 R /S /LI >> endobj %% Original object ID: 8165 0 10654 0 obj << /C /Pa9 /K [ 11252 0 R 8130 0 R ] /P 6427 0 R /S /LI >> endobj %% Original object ID: 8166 0 10655 0 obj << /C /Pa9 /K [ 11253 0 R 8132 0 R ] /P 6427 0 R /S /LI >> endobj %% Original object ID: 8167 0 10656 0 obj << /C /Pa9 /K [ 11254 0 R 8134 0 R ] /P 6427 0 R /S /LI >> endobj %% Original object 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] /P 6478 0 R /S /LI >> endobj %% Original object ID: 8051 0 10676 0 obj << /C /Pa9 /K [ 11275 0 R 8217 0 R ] /P 6478 0 R /S /LI >> endobj %% Original object ID: 8052 0 10677 0 obj << /C /Pa9 /K [ 11276 0 R 8219 0 R ] /P 6478 0 R /S /LI >> endobj %% Original object ID: 8053 0 10678 0 obj << /C /Pa9 /K [ 11277 0 R 8222 0 R ] /P 6478 0 R /S /LI >> endobj %% Original object ID: 8015 0 10679 0 obj << /C /Pa9 /K [ 11278 0 R 8225 0 R ] /P 6483 0 R /S /LI >> endobj %% Original object ID: 8016 0 10680 0 obj << /C /Pa9 /K [ 11279 0 R 8227 0 R ] /P 6483 0 R /S /LI >> endobj %% Original object ID: 8017 0 10681 0 obj << /C /Pa9 /K [ 11280 0 R 8230 0 R ] /P 6483 0 R /S /LI >> endobj %% Original object ID: 8018 0 10682 0 obj << /C /Pa9 /K [ 11281 0 R 8232 0 R ] /P 6483 0 R /S /LI >> endobj %% Original object ID: 8019 0 10683 0 obj << /C /Pa9 /K [ 11282 0 R 8234 0 R ] /P 6483 0 R /S /LI >> endobj %% Original object ID: 8020 0 10684 0 obj << /C /Pa9 /K [ 11283 0 R 8236 0 R ] /P 6483 0 R /S /LI >> endobj %% Original object ID: 8021 0 10685 0 obj << /C /Pa9 /K [ 11284 0 R 8239 0 R ] /P 6483 0 R /S /LI >> endobj %% Original object ID: 7996 0 10686 0 obj << /C /Pa9 /K [ 11285 0 R 8241 0 R ] /P 6488 0 R /S /LI >> endobj %% Original object ID: 7997 0 10687 0 obj << /C /Pa9 /K [ 11286 0 R 8243 0 R ] /P 6488 0 R /S /LI >> endobj %% Original object ID: 7998 0 10688 0 obj << /C /Pa9 /K [ 11287 0 R 8245 0 R ] /P 6488 0 R /S /LI >> endobj %% Original object ID: 7999 0 10689 0 obj << /C /Pa9 /K [ 11288 0 R 8248 0 R ] /P 6488 0 R /S /LI >> endobj %% Original object ID: 7975 0 10690 0 obj << /C /Pa9 /K [ 11291 0 R 8287 0 R ] /P 6501 0 R /S /LI >> endobj %% Original object ID: 7976 0 10691 0 obj << /C /Pa9 /K [ 11292 0 R 8290 0 R ] /P 6501 0 R /S /LI >> endobj %% Original object ID: 7960 0 10692 0 obj << /C /Pa9 /K [ 11289 0 R 8292 0 R ] /P 6506 0 R /S /LI >> endobj %% Original object ID: 7961 0 10693 0 obj << /C /Pa9 /K [ 11290 0 R 8274 0 R ] /P 6506 0 R /S /LI >> endobj %% Original object 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] /P 6562 0 R /S /LI >> endobj %% Original object ID: 7825 0 10713 0 obj << /C /Pa10 /K [ 11310 0 R 8364 0 R ] /P 6570 0 R /S /LI >> endobj %% Original object ID: 7826 0 10714 0 obj << /C /Pa10 /K [ 11311 0 R 8368 0 R ] /P 6570 0 R /S /LI >> endobj %% Original object ID: 7760 0 10715 0 obj << /C /Pa9 /K [ 11314 0 R 8392 0 R 12246 0 R ] /P 6589 0 R /S /LI >> endobj %% Original object ID: 7761 0 10716 0 obj << /C /Pa9 /K [ 11325 0 R 8407 0 R ] /P 6589 0 R /S /LI >> endobj %% Original object ID: 7762 0 10717 0 obj << /C /Pa9 /K [ 11326 0 R 8413 0 R ] /P 6589 0 R /S /LI >> endobj %% Original object ID: 7763 0 10718 0 obj << /C /Pa9 /K [ 11327 0 R 8417 0 R ] /P 6589 0 R /S /LI >> endobj %% Original object ID: 7747 0 10719 0 obj << /C /Pa9 /K [ 11328 0 R 8438 0 R ] /P 6595 0 R /S /LI >> endobj %% Original object ID: 7748 0 10720 0 obj << /C /Pa9 /K [ 11329 0 R 8441 0 R ] /P 6595 0 R /S /LI >> endobj %% Original object ID: 7749 0 10721 0 obj << /C /Pa9 /K [ 11330 0 R 8443 0 R ] /P 6595 0 R /S /LI >> endobj %% Original object ID: 7676 0 10722 0 obj << /C /Pa9 /K [ 11345 0 R 8505 0 R ] /P 6611 0 R /S /LI >> endobj %% Original object ID: 7677 0 10723 0 obj << /C /Pa9 /K [ 11346 0 R 8508 0 R ] /P 6611 0 R /S /LI >> endobj %% Original object ID: 7678 0 10724 0 obj << /C /Pa9 /K [ 11347 0 R 8510 0 R ] /P 6611 0 R /S /LI >> endobj %% Original object ID: 7679 0 10725 0 obj << /C /Pa9 /K [ 11348 0 R 8513 0 R ] /P 6611 0 R /S /LI >> endobj %% Original object ID: 7680 0 10726 0 obj << /C /Pa9 /K [ 11349 0 R 8517 0 R 12247 0 R ] /P 6611 0 R /S /LI >> endobj %% Original object ID: 7681 0 10727 0 obj << /C /Pa9 /K [ 11360 0 R 8531 0 R ] /P 6611 0 R /S /LI >> endobj %% Original object ID: 7631 0 10728 0 obj << /C /Pa9 /K [ 11331 0 R 8445 0 R ] /P 6613 0 R /S /LI >> endobj %% Original object ID: 7632 0 10729 0 obj << /C /Pa9 /K [ 11332 0 R 8448 0 R ] /P 6613 0 R /S /LI >> endobj %% Original object ID: 7633 0 10730 0 obj << /C /Pa9 /K [ 11333 0 R 8451 0 R 12248 0 R ] /P 6613 0 R /S /LI >> endobj %% Original object ID: 7634 0 10731 0 obj << /C /Pa9 /K [ 11344 0 R 8467 0 R ] /P 6613 0 R /S /LI >> endobj %% Original object ID: 7581 0 10732 0 obj << /C /Pa9 /K [ 11361 0 R 8548 0 R ] /P 6637 0 R /S /LI >> endobj %% Original object ID: 7582 0 10733 0 obj << /C /Pa9 /K [ 11362 0 R 8550 0 R ] /P 6637 0 R /S /LI >> endobj %% Original object ID: 7583 0 10734 0 obj << /C /Pa9 /K [ 11363 0 R 8553 0 R ] /P 6637 0 R /S /LI >> endobj %% Original object ID: 7561 0 10735 0 obj << /C /Pa9 /K [ 11364 0 R 8562 0 R ] /P 6656 0 R /S /LI >> endobj %% Original object ID: 7562 0 10736 0 obj << /C /Pa9 /K [ 11365 0 R 8573 0 R ] /P 6656 0 R /S /LI >> endobj %% Original object ID: 7534 0 10737 0 obj << /C /Pa9 /K [ 11366 0 R 8586 0 R ] /P 6685 0 R /S /LI >> endobj %% Original object ID: 7535 0 10738 0 obj << /C /Pa9 /K [ 11367 0 R 8589 0 R ] /P 6685 0 R /S /LI >> endobj %% Original object ID: 7517 0 10739 0 obj << /C /Pa9 /K [ 11368 0 R 8594 0 R ] /P 6689 0 R /S /LI >> endobj %% Original object 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] /P 6716 0 R /S /LI >> endobj %% Original object ID: 7416 0 10759 0 obj << /C /Pa9 /K [ 11388 0 R 8652 0 R ] /P 6716 0 R /S /LI >> endobj %% Original object ID: 7417 0 10760 0 obj << /C /Pa9 /K [ 11389 0 R 8654 0 R ] /P 6716 0 R /S /LI >> endobj %% Original object ID: 7418 0 10761 0 obj << /C /Pa9 /K [ 11390 0 R 8657 0 R ] /P 6716 0 R /S /LI >> endobj %% Original object ID: 7390 0 10762 0 obj << /C /Pa9 /K [ 11391 0 R 8659 0 R ] /P 6719 0 R /S /LI >> endobj %% Original object ID: 7391 0 10763 0 obj << /C /Pa9 /K [ 11392 0 R 8661 0 R ] /P 6719 0 R /S /LI >> endobj %% Original object ID: 7392 0 10764 0 obj << /C /Pa9 /K [ 11393 0 R 8663 0 R ] /P 6719 0 R /S /LI >> endobj %% Original object ID: 7393 0 10765 0 obj << /C /Pa9 /K [ 11394 0 R 8666 0 R ] /P 6719 0 R /S /LI >> endobj %% Original object ID: 7394 0 10766 0 obj << /C /Pa9 /K [ 11395 0 R 8669 0 R ] /P 6719 0 R /S /LI >> endobj %% Original object ID: 7369 0 10767 0 obj << /C /Pa9 /K [ 11398 0 R 8708 0 R ] /P 6732 0 R /S /LI >> endobj %% Original object ID: 7370 0 10768 0 obj << /C /Pa9 /K [ 11399 0 R 8711 0 R ] /P 6732 0 R /S /LI >> endobj %% Original object ID: 7353 0 10769 0 obj << /C /Pa9 /K [ 11396 0 R 8713 0 R ] /P 6737 0 R /S /LI >> endobj %% Original object ID: 7354 0 10770 0 obj << /C /Pa9 /K [ 11397 0 R 8694 0 R ] /P 6737 0 R /S /LI >> endobj %% Original object ID: 7332 0 10771 0 obj << /C /Pa9 /K [ 11406 0 R 8746 0 R ] /P 6753 0 R /S /LI >> endobj %% Original object ID: 7333 0 10772 0 obj << /C /Pa9 /K [ 11407 0 R 8748 0 R ] /P 6753 0 R /S /LI >> endobj %% Original object ID: 7323 0 10773 0 obj << /C /Pa9 /K [ 11408 0 R 8750 0 R ] /P 6755 0 R /S /LI >> endobj %% Original object ID: 7324 0 10774 0 obj << /C /Pa9 /K [ 11409 0 R 8752 0 R ] /P 6755 0 R /S /LI >> endobj %% Original object ID: 7308 0 10775 0 obj << /C /Pa9 /K [ 11402 0 R 8754 0 R ] /P 6756 0 R /S /LI >> endobj %% Original object ID: 7309 0 10776 0 obj << /C /Pa9 /K [ 11403 0 R 8729 0 R ] /P 6756 0 R /S /LI >> endobj %% Original object 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0 R 8838 0 R ] /P 6828 0 R /S /LI >> endobj %% Original object ID: 7148 0 10796 0 obj << /C /Pa9 /K [ 11435 0 R 8843 0 R ] /P 6828 0 R /S /LI >> endobj %% Original object ID: 7132 0 10797 0 obj << /C /Pa9 /K [ 11436 0 R 8861 0 R ] /P 6834 0 R /S /LI >> endobj %% Original object ID: 7133 0 10798 0 obj << /C /Pa9 /K [ 11437 0 R 8864 0 R ] /P 6834 0 R /S /LI >> endobj %% Original object ID: 7134 0 10799 0 obj << /C /Pa9 /K [ 11438 0 R 8866 0 R ] /P 6834 0 R /S /LI >> endobj %% Original object ID: 7064 0 10800 0 obj << /C /Pa9 /K [ 11453 0 R 8929 0 R ] /P 6850 0 R /S /LI >> endobj %% Original object ID: 7065 0 10801 0 obj << /C /Pa9 /K [ 11454 0 R 8932 0 R ] /P 6850 0 R /S /LI >> endobj %% Original object ID: 7066 0 10802 0 obj << /C /Pa9 /K [ 11455 0 R 8934 0 R ] /P 6850 0 R /S /LI >> endobj %% Original object ID: 7067 0 10803 0 obj << /C /Pa9 /K [ 11456 0 R 8937 0 R ] /P 6850 0 R /S /LI >> endobj %% Original object ID: 7068 0 10804 0 obj << /C /Pa9 /K [ 11457 0 R 8941 0 R 12250 0 R ] /P 6850 0 R /S /LI >> endobj %% Original object ID: 7069 0 10805 0 obj << /C /Pa9 /K [ 11468 0 R 8955 0 R ] /P 6850 0 R /S /LI >> endobj %% Original object ID: 7019 0 10806 0 obj << /C /Pa9 /K [ 11439 0 R 8903 0 R ] /P 6852 0 R /S /LI >> endobj %% Original object ID: 7020 0 10807 0 obj << /C /Pa9 /K [ 11440 0 R 8906 0 R ] /P 6852 0 R /S /LI >> endobj %% Original object ID: 7021 0 10808 0 obj << /C /Pa9 /K [ 11441 0 R 8909 0 R 12251 0 R ] /P 6852 0 R /S /LI >> endobj %% Original object ID: 7022 0 10809 0 obj << /C /Pa9 /K [ 11452 0 R 8925 0 R ] /P 6852 0 R /S /LI >> endobj %% Original object ID: 6968 0 10810 0 obj << /C /Pa9 /K [ 11469 0 R 8961 0 R ] /P 6872 0 R /S /LI >> endobj %% Original object ID: 6969 0 10811 0 obj << /C /Pa9 /K [ 11470 0 R 8963 0 R ] /P 6872 0 R /S /LI >> endobj %% Original object ID: 6970 0 10812 0 obj << /C /Pa9 /K [ 11471 0 R 8966 0 R ] /P 6872 0 R /S /LI >> endobj %% Original object ID: 6951 0 10813 0 obj << /C /Pa9 /K [ 11472 0 R 8976 0 R ] /P 6888 0 R /S /LI >> endobj %% Original object ID: 6952 0 10814 0 obj << /C /Pa9 /K [ 11473 0 R 8989 0 R ] /P 6888 0 R /S /LI >> endobj %% Original object ID: 6929 0 10815 0 obj << /C /Pa9 /K [ 11474 0 R 9003 0 R ] /P 6914 0 R /S /LI >> endobj %% Original object ID: 6930 0 10816 0 obj << /C /Pa9 /K [ 11475 0 R 9006 0 R ] /P 6914 0 R /S /LI >> endobj %% Original object ID: 6911 0 10817 0 obj << /C /Pa9 /K [ 11476 0 R 9011 0 R ] /P 6919 0 R /S /LI >> endobj %% Original object ID: 6912 0 10818 0 obj << /C /Pa9 /K [ 11477 0 R 9013 0 R ] /P 6919 0 R /S /LI >> endobj %% Original object ID: 6913 0 10819 0 obj << /C /Pa9 /K [ 11478 0 R 9015 0 R ] /P 6919 0 R /S /LI >> endobj %% Original object ID: 6914 0 10820 0 obj << /C /Pa9 /K [ 11479 0 R 9017 0 R ] /P 6919 0 R /S /LI >> endobj %% Original object ID: 6898 0 10821 0 obj << /C /Pa9 /K [ 11485 0 R 9041 0 R ] /P 6920 0 R /S /LI >> endobj %% Original object ID: 6899 0 10822 0 obj << /C /Pa9 /K [ 11486 0 R 9048 0 R ] /P 6920 0 R /S /LI >> endobj %% Original object 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] /P 6946 0 R /S /LI >> endobj %% Original object ID: 6779 0 10842 0 obj << /C /Pa9 /K [ 11501 0 R 9089 0 R ] /P 6946 0 R /S /LI >> endobj %% Original object ID: 6780 0 10843 0 obj << /C /Pa9 /K [ 11502 0 R 9092 0 R ] /P 6946 0 R /S /LI >> endobj %% Original object ID: 6781 0 10844 0 obj << /C /Pa9 /K [ 11503 0 R 9095 0 R ] /P 6946 0 R /S /LI >> endobj %% Original object ID: 6755 0 10845 0 obj << /C /Pa9 /K [ 11506 0 R 9133 0 R ] /P 6959 0 R /S /LI >> endobj %% Original object ID: 6756 0 10846 0 obj << /C /Pa9 /K [ 11507 0 R 9136 0 R ] /P 6959 0 R /S /LI >> endobj %% Original object ID: 6738 0 10847 0 obj << /C /Pa9 /K [ 11504 0 R 9138 0 R ] /P 6964 0 R /S /LI >> endobj %% Original object ID: 6739 0 10848 0 obj << /C /Pa9 /K [ 11505 0 R 9119 0 R ] /P 6964 0 R /S /LI >> endobj %% Original object ID: 6718 0 10849 0 obj << /C /Pa9 /K [ 11514 0 R 9167 0 R ] /P 6978 0 R /S /LI >> endobj %% Original object ID: 6719 0 10850 0 obj << /C /Pa9 /K [ 11515 0 R 9169 0 R ] /P 6978 0 R /S /LI >> endobj %% Original object ID: 6704 0 10851 0 obj << /C /Pa9 /K [ 11510 0 R 9175 0 R ] /P 6979 0 R /S /LI >> endobj %% Original object ID: 6705 0 10852 0 obj << /C /Pa9 /K [ 11511 0 R 9153 0 R ] /P 6979 0 R /S /LI >> endobj %% Original object ID: 6695 0 10853 0 obj << /C /Pa9 /K [ 11516 0 R 9171 0 R ] /P 6981 0 R /S /LI >> endobj %% Original object ID: 6696 0 10854 0 obj << /C /Pa9 /K [ 11517 0 R 9173 0 R ] /P 6981 0 R /S /LI >> endobj %% Original object ID: 6686 0 10855 0 obj << /C /Pa9 /K [ 11508 0 R 9143 0 R ] /P 6982 0 R /S /LI >> endobj %% Original object ID: 6687 0 10856 0 obj << /C /Pa9 /K [ 11509 0 R 9146 0 R ] /P 6982 0 R /S /LI >> endobj %% Original object ID: 6675 0 10857 0 obj << /C /Pa9 /K [ 11512 0 R 9157 0 R ] /P 6986 0 R /S /LI >> endobj %% Original object ID: 6676 0 10858 0 obj << /C /Pa9 /K [ 11513 0 R 9159 0 R ] /P 6986 0 R /S /LI >> endobj %% Original object ID: 6665 0 10859 0 obj << /C /Pa9 /K [ 11522 0 R 9193 0 R ] /P 6997 0 R /S /LI >> endobj %% Original object 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J f b‚© 2017 The Monotype Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. This layout logic for Biblical Hebrew is open source software under the MIT License; see embedded license description for details.Arial is a trademark of The Monotype Corporation.© 2017 The Monotype Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. This layout logic for Biblical Hebrew is open source software under the MIT License; see embedded license description for details.DOQTOS+ArialMTDOQTOS+ArialMTDOQTOS+ArialMTArial is a trademark of The Monotype Corporation.© 2017 The Monotype Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. 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All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. This layout logic for Biblical Hebrew is open source software under the MIT License; see embedded license description for details.Arial is a trademark of The Monotype Corporation.© 2017 The Monotype Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. This layout logic for Biblical Hebrew is open source software under the MIT License; see embedded license description for details.PBQIAU+Arial-BoldMTPBQIAU+Arial-BoldMTPBQIAU+Arial-BoldMTArial is a trademark of The Monotype Corporation.© 2017 The Monotype Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright © 2003 & 2007, Ralph Hancock & John Hudson. 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All rights reserved.QXTVRR+CambriaMathRegularQXTVRR+CambriaMathQXTVRR+CambriaMathQXTVRR+CambriaMathCambria is a trademark of the Microsoft group of companies.ą ţ´ J ¸ú´ J ¸ů´ J ¸ř´ J ¸÷´ J ¸ö´ J ¸đ´ J ¸ď´ J ¸î´ J ¸í´ J ¸ě´ J ¸ë´ J ¸ć´ J ¸ĺ´ J ¸ä´ J ¸ă´ J ¸â´ J ¸á´ J ¸ŕ´ J ¸Ó´ J ¸Ň´ J ¸Ń´ J ¸Ď´ J ¸δ J ¸Í´ J ¸Ě´ J ¸ ´ J ¸Ź´ J ¸Ž´ J ¸Š´ J ¸´ J ¸‡´ J ¸†´ J ¸[´ J ¸Z´ J ¸Y´ J ¸X´ J ¸T´ J ¸P´ J ¸L´ J ¸K´ J ¸J´ J ¸6´ J ¸0´ J ¸/´ J ¸-´ J ¸,´ J ¸ ´ J ¸´ J ¸@˙ J ô J ň J ń J đ J ď J í J ě J ę J ĺ J ä J ă J á J Ţ J Ú J Ř J Ó J Í J Ě J Ę J É J Č J Ć J Ä J  J Ŕ J ż J ˝ J ł J ± J Ż J Ą J ¤ J   J Ž J Ť J Ś J ‹ J Š J ‰ J … J „ J @>J € J  J ~ J } J b J Q J P J H J B J  JAcAA/A?AOA_AoAAŹAźAŻAżAĎA _ę€ôô ô°ôŔôĐôŕôđô/3?3O3_3o33Ź3ź3Ż3ż3 4/4?4O4_4o44Ď#ß#ď###?#_#ź#@#đâ°ýŔýŔýĐýŕýđýĐýŕýđýŔ˙Đ˙ŕ˙đ˙pA %Ŕ%Đ%ŕ%đ%@ ŕľđľŕľđľA!?!XXŕX ´&Aśś/ś?śOś_śßśďś˙ś@SßŕÔŐ{|{|ŃŇvwmploknknrtugjfieheh…qszC!yC!A1’™’’,’™š› ŤŽŹ Š‹Ś ™‹™™ź™»™Ű™Ą‹§ źšˇ śŽž ˙莲#9ą˙蚲#9A‚}+|+~z+}z+zW+wg+gW˛+ ¸p˛ 9˝rW+nW˛+ ¸Wł139 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Vivamus quis tortor vitae nissim rutrum. risus porta vehicula. Nam dui ligula, fringilla a, euismod sodales, sollic- itudin vel, wisi. Morbi auctor lorem non justo. Nam Fusce mauris. Vestibulum luctus nibh at lectus. lacus libero, pretium at, lobortis vitae, ultricies et, Sed bibendum, nulla a faucibus semper, leo velit ul- tellus. Donec aliquet, tortor sed accumsan biben- tricies tellus, ac venenatis arcu wisi vel nisl. Vestibu- dum, erat ligula aliquet magna, vitae ornare odio lum diam. Aliquam pellentesque, augue quis sagittis metus a mi. Morbi ac orci et nisl hendrerit mollis. posuere, turpis lacus congue quam, in hendrerit risus Suspendisse ut massa. Cras nec ante. Pellentesque eros eget felis. Maecenas eget erat in sapien mattis a nulla. Cum sociis natoque penatibus et magnis dis porttitor. Vestibulum porttitor. Nulla facilisi. Sed parturient montes, nascetur ridiculus mus. Aliquam a turpis eu lacus commodo facilisis. Morbi fringilla, tincidunturna. 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0000006708 00000 n trailer <> startxref 7164 %%EOF pypdf-6.1.2/sample-files/000077500000000000000000000000001507516550200152315ustar00rootroot00000000000000pypdf-6.1.2/tests/000077500000000000000000000000001507516550200140125ustar00rootroot00000000000000pypdf-6.1.2/tests/__init__.py000066400000000000000000000116361507516550200161320ustar00rootroot00000000000000import concurrent.futures import ssl import sys import urllib.request from pathlib import Path from typing import Optional from urllib.error import HTTPError if sys.version_info >= (3, 11): from typing import Self else: from typing_extensions import Self import yaml from pypdf.generic import DictionaryObject, IndirectObject def get_data_from_url(url: Optional[str] = None, name: Optional[str] = None) -> bytes: """ Download a File from a URL and return its contents. This function makes sure the PDF is not downloaded too often. This function is a last resort for PDF files where we are uncertain if we may add it for testing purposes to https://github.com/py-pdf/sample-files Args: url: location of the PDF file name: unique name across all files Returns: Read File as bytes """ if name is None: raise ValueError("A name must always be specified") cache_dir = Path(__file__).parent / "pdf_cache" if not cache_dir.exists(): cache_dir.mkdir() cache_path = cache_dir / name if url is not None: if url.startswith("file://"): with open(url[7:].replace("\\", "/"), "rb") as fp: return fp.read() if not cache_path.exists(): ssl._create_default_https_context = ssl._create_unverified_context attempts = 0 while attempts < 3: try: with urllib.request.urlopen( # noqa: S310 url ) as response, cache_path.open("wb") as out_file: out_file.write(response.read()) break except HTTPError as e: if attempts < 3: attempts += 1 else: raise e with open(cache_path, "rb") as fp: return fp.read() def _strip_position(line: str) -> str: """ Remove the location information. The message WARNING pypdf._reader:_utils.py:364 Xref table not zero-indexed. becomes Xref table not zero-indexed. Args: line: the original line Returns: A line with stripped position """ line = ".py".join(line.split(".py:")[1:]) return " ".join(line.split(" ")[1:]) def normalize_warnings(caplog_text: str) -> list[str]: return [_strip_position(line) for line in caplog_text.strip().split("\n")] class ReaderDummy: def __init__(self, strict=False) -> None: self.strict = strict def get_object(self, indirect_reference): class DummyObj: def get_object(self) -> "DummyObj": return self return DictionaryObject() def get_reference(self, obj): return IndirectObject(idnum=1, generation=1, pdf=self) def is_sublist(child_list, parent_list): """ Check if child_list is a sublist of parent_list, with respect to * elements order * elements repetition Elements are compared using `==` """ if len(child_list) == 0: return True if len(parent_list) == 0: return False if parent_list[0] == child_list[0]: return is_sublist(child_list[1:], parent_list[1:]) return is_sublist(child_list, parent_list[1:]) def read_yaml_to_list_of_dicts(yaml_file: Path) -> list[dict[str, str]]: with open(yaml_file) as yaml_input: return yaml.safe_load(yaml_input) def download_test_pdfs(): """ Run this before the tests are executed to ensure you have everything locally. This is especially important to avoid pytest timeouts. """ pdfs = read_yaml_to_list_of_dicts(Path(__file__).parent / "example_files.yaml") with concurrent.futures.ThreadPoolExecutor(max_workers=20) as executor: futures = [ executor.submit(get_data_from_url, pdf["url"], name=pdf["local_filename"]) for pdf in pdfs ] concurrent.futures.wait(futures) def test_csv_consistency(): pdfs = read_yaml_to_list_of_dicts(Path(__file__).parent / "example_files.csv") # Ensure the names are unique assert len(pdfs) == len({pdf["name"] for pdf in pdfs}) # Ensure the urls are unique assert len(pdfs) == len({pdf["url"] for pdf in pdfs}) class PILContext: """Allow changing the PIL/Pillow configuration for some limited scope.""" def __init__(self) -> None: self._saved_load_truncated_images = False def __enter__(self) -> Self: # Allow loading incomplete images. from PIL import ImageFile # noqa: PLC0415 self._saved_load_truncated_images = ImageFile.LOAD_TRUNCATED_IMAGES ImageFile.LOAD_TRUNCATED_IMAGES = True return self def __exit__(self, type_, value, traceback) -> Optional[bool]: from PIL import ImageFile # noqa: PLC0415 ImageFile.LOAD_TRUNCATED_IMAGES = self._saved_load_truncated_images if type_: # Error. return None return True pypdf-6.1.2/tests/bench.py000066400000000000000000000152011507516550200154420ustar00rootroot00000000000000""" Benchmark the speed of pypdf. The results are on https://py-pdf.github.io/pypdf/dev/bench/ Please keep in mind that the variance is high. """ from io import BytesIO from pathlib import Path from tempfile import NamedTemporaryFile import pytest import pypdf from pypdf import PageObject, PdfReader, PdfWriter, Transformation from pypdf.generic import Destination, read_string_from_stream from . import get_data_from_url TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" SAMPLE_ROOT = PROJECT_ROOT / "sample-files" def page_ops(pdf_path, password): pdf_path = RESOURCE_ROOT / pdf_path reader = PdfReader(pdf_path) writer = PdfWriter() if password: reader.decrypt(password) page = reader.pages[0] writer.add_page(page) op = Transformation().rotate(90).scale(1.2) page.add_transformation(op) page.merge_page(page) op = Transformation().scale(1).translate(tx=1, ty=1) page.add_transformation(op) page.merge_page(page) op = Transformation().rotate(90).scale(1).translate(tx=1, ty=1) page.add_transformation(op) page.merge_page(page) page.add_transformation((1, 0, 0, 0, 0, 0)) page.scale(2, 2) page.scale_by(0.5) page.scale_to(100, 100) page = writer.pages[0] page.compress_content_streams() page.extract_text() def test_page_operations(benchmark): """ Apply various page operations. Rotation, scaling, translation, content stream compression, text extraction """ benchmark(page_ops, "libreoffice-writer-password.pdf", "openpassword") def merge(): pdf_path = RESOURCE_ROOT / "crazyones.pdf" outline = RESOURCE_ROOT / "pdflatex-outline.pdf" pdf_forms = RESOURCE_ROOT / "pdflatex-forms.pdf" pdf_pw = RESOURCE_ROOT / "libreoffice-writer-password.pdf" writer = PdfWriter() # string path: writer.append(pdf_path) writer.append(outline) writer.append(pdf_path, pages=pypdf.pagerange.PageRange(slice(0, 0))) writer.append(pdf_forms) # Merging an encrypted file reader = PdfReader(pdf_pw) reader.decrypt("openpassword") writer.append(reader) # PdfReader object: writer.append(PdfReader(pdf_path), outline_item="True") # File handle with open(pdf_path, "rb") as fh: writer.append(fh) outline_item = writer.add_outline_item("An outline item", 0) writer.add_outline_item("deeper", 0, parent=outline_item) writer.add_metadata({"/Author": "Martin Thoma"}) writer.add_named_destination("title", 0) writer.set_page_layout("/SinglePage") writer.page_mode = "/UseThumbs" with NamedTemporaryFile(suffix=".pdf") as target_file: write_path = target_file.name writer.write(write_path) writer.close() # Check if outline is correct reader = PdfReader(write_path) assert [ el.title for el in reader._get_outline() if isinstance(el, Destination) ] == [ "Foo", "Bar", "Baz", "Foo", "Bar", "Baz", "Foo", "Bar", "Baz", "True", "An outline item", ] def test_merge(benchmark): """ Apply various page operations. Rotation, scaling, translation, content stream compression, text extraction """ benchmark(merge) def text_extraction(pdf_path): with open(pdf_path, mode="rb") as fd: reader = PdfReader(fd) text = "" for page in reader.pages: text += page.extract_text() return text def test_text_extraction(benchmark): file_path = SAMPLE_ROOT / "009-pdflatex-geotopo/GeoTopo.pdf" benchmark(text_extraction, file_path) def read_string_from_stream_performance(): stream = BytesIO(b"(" + b"".join([b"x"] * 1024 * 256) + b")") assert read_string_from_stream(stream) def test_read_string_from_stream_performance(benchmark): """ This test simulates reading an embedded base64 image of 256kb. It should be faster than a second, even on ancient machines. Runs < 100ms on a 2019 notebook. Takes 10 seconds prior to #1350. """ benchmark(read_string_from_stream_performance) def image_new_property(data): reader = PdfReader(data) assert reader.pages[0].images.keys() == [ "/I0", "/I1", "/I2", "/I3", "/I4", "/I5", "/I6", "/I7", "/I8", "/I9", ["/TPL1", "/Image5"], ["/TPL2", "/Image53"], ["/TPL2", "/Image37"], ["/TPL2", "/Image49"], ["/TPL2", "/Image51"], ["/TPL2", "/Image39"], ["/TPL2", "/Image57"], ["/TPL2", "/Image55"], ["/TPL2", "/Image43"], ["/TPL2", "/Image30"], ["/TPL2", "/Image22"], ["/TPL2", "/Image41"], ["/TPL2", "/Image47"], ["/TPL2", "/Image45"], ["/TPL3", "/Image65"], ["/TPL3", "/Image30"], ["/TPL3", "/Image61"], ["/TPL4", "/Image30"], ["/TPL5", "/Image30"], ["/TPL6", "/Image30"], ["/TPL7", "/Image30"], ["/TPL8", "/Image30"], ["/TPL9", "/Image30"], ["/TPL10", "/Image30"], ["/TPL11", "/Image30"], ["/TPL12", "/Image30"], ] assert len(reader.pages[0].images.items()) == 36 assert reader.pages[0].images[0].name == "I0.png" assert len(reader.pages[0].images[-1].data) > 10000 assert reader.pages[0].images["/TPL1", "/Image5"].image.format == "JPEG" assert ( reader.pages[0].images["/I0"].indirect_reference.get_object() == reader.pages[0]["/Resources"]["/XObject"]["/I0"] ) list(reader.pages[0].images[0:2]) with pytest.raises(TypeError): reader.pages[0].images[b"0"] with pytest.raises(IndexError): reader.pages[0].images[9999] # just for test coverage: with pytest.raises(KeyError): reader.pages[0]._get_image(["test"], reader.pages[0]) assert list(PageObject(None, None).images) == [] @pytest.mark.enable_socket def test_image_new_property_performance(benchmark): url = "https://github.com/py-pdf/pypdf/files/11219022/pdf_font_garbled.pdf" name = "pdf_font_garbled.pdf" data = BytesIO(get_data_from_url(url, name=name)) benchmark(image_new_property, data) def image_extraction(data): reader = PdfReader(data) list(reader.pages[0].images) @pytest.mark.enable_socket def test_large_compressed_image_performance(benchmark): url = "https://github.com/py-pdf/pypdf/files/15306199/file_with_large_compressed_image.pdf" data = BytesIO(get_data_from_url(url, name="file_with_large_compressed_image.pdf")) benchmark(image_extraction, data) pypdf-6.1.2/tests/conftest.py000066400000000000000000000010201507516550200162020ustar00rootroot00000000000000"""Fixtures that are available automatically for all tests.""" import uuid from pathlib import Path import pytest TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" @pytest.fixture(scope="session") def pdf_file_path(tmp_path_factory): return tmp_path_factory.mktemp("pypdf-data") / f"{uuid.uuid4()}.pdf" @pytest.fixture(scope="session") def txt_file_path(tmp_path_factory): return tmp_path_factory.mktemp("pypdf-data") / f"{uuid.uuid4()}.txt" pypdf-6.1.2/tests/example_files.yaml000066400000000000000000000157531507516550200175260ustar00rootroot00000000000000- local_filename: 2201.00214.pdf url: https://arxiv.org/pdf/2201.00214.pdf - 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local_filename: iss1912.pdf url: https://github.com/py-pdf/pypdf/files/11845099/GeoTopo-komprimiert.pdf - local_filename: calRGB.pdf url: https://github.com/py-pdf/pypdf/files/12061061/tt.pdf - local_filename: 2023USDC.pdf url: https://github.com/py-pdf/pypdf/files/12090523/2023.USDC_Circle.Examination.Report.May.2023.pdf - local_filename: iss1982_im1.png url: https://github.com/py-pdf/pypdf/files/12144094/im1.png.txt - local_filename: iss1982_im2.png url: https://github.com/py-pdf/pypdf/files/12144093/im2.png.txt - local_filename: usa.png url: https://github.com/py-pdf/pypdf/assets/4083478/56c93021-33cd-4387-ae13-5cbe7e673f42 - local_filename: paid.pdf url: https://github.com/py-pdf/pypdf/files/12050253/tt.pdf - local_filename: Pesquisa-de-Precos-Combustiveis-novembro-2023.pdf url: https://www.joinville.sc.gov.br/wp-content/uploads/2023/11/Pesquisa-de-Precos-Combustiveis-novembro-2023.pdf - local_filename: iss2138.pdf url: https://github.com/py-pdf/pypdf/files/12483807/AEO.1172.pdf - local_filename: iss3268.pdf url: https://github.com/user-attachments/files/20060394/broken.pdf - local_filename: direct-link.pdf url: https://github.com/user-attachments/files/20348304/tst.pdf - local_filename: named-reference.pdf url: https://github.com/user-attachments/files/20455804/MinimalJob.pdf - local_filename: large_lzw_example_encoded.dat url: https://github.com/user-attachments/files/20923310/large_lzw_example_encoded.dat.txt - local_filename: issue-3419.pdf url: https://github.com/user-attachments/files/21578875/layout-parser-paper-with-empty-pages.pdf - local_filename: issue-3429.pdf url: https://github.com/user-attachments/files/21711469/bomb.pdf pypdf-6.1.2/tests/generic/000077500000000000000000000000001507516550200154265ustar00rootroot00000000000000pypdf-6.1.2/tests/generic/__init__.py000066400000000000000000000000001507516550200175250ustar00rootroot00000000000000pypdf-6.1.2/tests/generic/test_files.py000066400000000000000000000533211507516550200201450ustar00rootroot00000000000000"""Test the pypdf.generic._files module.""" import datetime import shutil import subprocess from io import BytesIO from pathlib import Path import pytest from pypdf import PdfReader, PdfWriter from pypdf.constants import AFRelationship from pypdf.errors import PdfReadError, PyPdfError from pypdf.generic import ( ArrayObject, ByteStringObject, DictionaryObject, EmbeddedFile, IndirectObject, NameObject, NullObject, NumberObject, TextStringObject, create_string_object, ) from tests import get_data_from_url TESTS_ROOT = Path(__file__).parent.parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent SAMPLE_ROOT = PROJECT_ROOT / "sample-files" PDFATTACH_BINARY = shutil.which("pdfattach") @pytest.mark.skipif(PDFATTACH_BINARY is None, reason="Requires poppler-utils") def test_embedded_file__basic(tmpdir): clean_path = SAMPLE_ROOT / "002-trivial-libre-office-writer" / "002-trivial-libre-office-writer.pdf" attached_path = tmpdir / "attached.pdf" file_path = tmpdir / "test.txt" file_path.write_binary(b"Hello World\n") subprocess.run([PDFATTACH_BINARY, clean_path, file_path, attached_path]) # noqa: S603 with PdfReader(str(attached_path)) as reader: attachment = next(iter(EmbeddedFile._load(reader.root_object))) assert attachment.name == "test.txt" assert attachment.alternative_name == "test.txt" assert attachment.description is None assert attachment.associated_file_relationship == AFRelationship.UNSPECIFIED assert attachment.subtype is None assert attachment.content == b"Hello World\n" assert attachment.size == 12 assert attachment.creation_date is None assert attachment.modification_date is None assert attachment.checksum is None assert repr(attachment) == "" def test_embedded_file__artificial(): # No alternative name. pdf_object = DictionaryObject(answer=42) attachment = EmbeddedFile(name="dummy", pdf_object=pdf_object) assert attachment.alternative_name is None # No /EF. with pytest.raises(PdfReadError, match=f"/EF entry not found: {pdf_object}"): _ = attachment._embedded_file # Empty /EF dictionary. pdf_object = DictionaryObject() pdf_object[NameObject("/EF")] = DictionaryObject() attachment = EmbeddedFile(name="dummy", pdf_object=pdf_object) with pytest.raises(PdfReadError, match=r"No /\(U\)F key found in file dictionary: {}"): _ = attachment._embedded_file # Missing /Params key. pdf_object[NameObject("/EF")] = DictionaryObject() pdf_object[NameObject("/EF")][NameObject("/F")] = DictionaryObject(answer=42) assert attachment._params == DictionaryObject() # An actual checksum is set. # Generated using `hashlib.md5(b"Hello World!\n").digest()` params = DictionaryObject() params[NameObject("/CheckSum")] = ByteStringObject(b"\x8d\xdd\x8b\xe4\xb1y\xa5)\xaf\xa5\xf2\xff\xaeK\x98X") pdf_object[NameObject("/EF")][NameObject("/F")][NameObject("/Params")] = params assert attachment.checksum == b"\x8d\xdd\x8b\xe4\xb1y\xa5)\xaf\xa5\xf2\xff\xaeK\x98X" @pytest.mark.enable_socket def test_embedded_file__kids(): # Generated using the instructions available from # https://medium.com/@pymupdf/zugferd-and-ghostscript-how-to-create-industry-standard-and-compliant-pdf-e-invoices-83c9fde31ee5 # Notes: # * Yes, we need the full paths. Otherwise, the output file will only have an empty page. # * The XML file has been a custom basic text file. # * The input PDF file has been the `002-trivial-libre-office-writer.pdf` file. url = "https://github.com/user-attachments/files/18691309/embedded_files_kids.pdf" name = "embedded_files_kids.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) attachments = list(EmbeddedFile._load(reader.root_object)) assert len(attachments) == 1 attachment = attachments[0] assert attachment.name == "factur-x.xml" assert attachment.alternative_name == "factur-x.xml" assert attachment.description == "ZUGFeRD electronic invoice" assert attachment.associated_file_relationship == AFRelationship.ALTERNATIVE assert attachment.subtype == "/text/xml" assert attachment.content.startswith(b"Hello World!\n\nLorem ipsum dolor sit amet, ") assert attachment.content.endswith(b"\ntakimata sanctus est Lorem ipsum dolor sit amet.\n") assert attachment.size == 606 assert attachment.creation_date is None assert attachment.modification_date == datetime.datetime( 2013, 1, 21, 8, 14, 33, tzinfo=datetime.timezone(datetime.timedelta(hours=1)) ) assert attachment.checksum is None assert repr(attachment) == "" # No /Names in /Kids. del ( reader.root_object[NameObject("/Names")][NameObject("/EmbeddedFiles")][NameObject("/Kids")][0] .get_object()[NameObject("/Names")] ) attachments = list(EmbeddedFile._load(reader.root_object)) assert attachments == [] @pytest.mark.enable_socket def test_embedded_file__ensure_params__existing_params(): url = "https://github.com/user-attachments/files/18691309/embedded_files_kids.pdf" name = "embedded_files_kids.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) attachments = list(EmbeddedFile._load(reader.root_object)) assert len(attachments) == 1 attachment = attachments[0] assert "/Params" in attachment._embedded_file params_dict = attachment._ensure_params assert isinstance(params_dict, DictionaryObject) assert NameObject("/ModDate") in params_dict original_mod_date = params_dict.get(NameObject("/ModDate")) params_dict[NameObject("/TestParam")] = TextStringObject("test_value") assert params_dict[NameObject("/TestParam")] == TextStringObject("test_value") assert params_dict[NameObject("/ModDate")] == original_mod_date params_dict2 = attachment._ensure_params assert params_dict is params_dict2 assert params_dict2[NameObject("/TestParam")] == TextStringObject("test_value") def test_embedded_file__name_is_read_only(): writer = PdfWriter() embedded_file = writer.add_attachment("test.txt", b"content") assert embedded_file.name == "test.txt" with pytest.raises(AttributeError): embedded_file.name = "new_name.txt" def test_embedded_file__alternative_name_setter(): writer = PdfWriter() embedded_file = writer.add_attachment("test.txt", b"content") embedded_file.alternative_name = TextStringObject("Alternative Name") assert embedded_file.alternative_name == "Alternative Name" embedded_file.alternative_name = None if NameObject("/UF") in embedded_file.pdf_object: assert embedded_file.pdf_object[NameObject("/UF")] == NullObject() if NameObject("/F") in embedded_file.pdf_object: assert embedded_file.pdf_object[NameObject("/F")] == NullObject() assert embedded_file.alternative_name is None pdf_string = TextStringObject("PDF String") embedded_file.alternative_name = pdf_string assert embedded_file.alternative_name == "PDF String" def test_embedded_file__alternative_name__uf_key_only(): writer = PdfWriter() embedded_file = writer.add_attachment("test.txt", b"content") embedded_file.pdf_object[NameObject("/UF")] = create_string_object("original_uf") del embedded_file.pdf_object[NameObject("/F")] assert NameObject("/UF") in embedded_file.pdf_object assert NameObject("/F") not in embedded_file.pdf_object embedded_file.alternative_name = None assert embedded_file.pdf_object[NameObject("/UF")] == NullObject() assert NameObject("/F") not in embedded_file.pdf_object embedded_file.alternative_name = TextStringObject("new_uf") assert embedded_file.pdf_object[NameObject("/UF")] == create_string_object("new_uf") assert embedded_file.pdf_object[NameObject("/F")] == create_string_object("new_uf") def test_embedded_file__alternative_name__f_key_only(): writer = PdfWriter() embedded_file = writer.add_attachment("test.txt", b"content") embedded_file.pdf_object[NameObject("/F")] = create_string_object("original_f") if NameObject("/UF") in embedded_file.pdf_object: del embedded_file.pdf_object[NameObject("/UF")] assert NameObject("/F") in embedded_file.pdf_object assert NameObject("/UF") not in embedded_file.pdf_object embedded_file.alternative_name = None assert embedded_file.pdf_object[NameObject("/F")] == NullObject() assert NameObject("/UF") not in embedded_file.pdf_object embedded_file.alternative_name = TextStringObject("new_f") assert embedded_file.pdf_object[NameObject("/F")] == create_string_object("new_f") assert embedded_file.pdf_object[NameObject("/UF")] == create_string_object("new_f") def test_embedded_file__alternative_name__both_f_and_uf(): writer = PdfWriter() embedded_file = writer.add_attachment("test.txt", b"content") embedded_file.pdf_object[NameObject("/F")] = create_string_object("original_f") embedded_file.pdf_object[NameObject("/UF")] = create_string_object("original_uf") embedded_file.alternative_name = TextStringObject("new_name") assert embedded_file.pdf_object[NameObject("/F")] == create_string_object("new_name") assert embedded_file.pdf_object[NameObject("/UF")] == create_string_object("new_name") assert embedded_file.alternative_name == "new_name" embedded_file.alternative_name = None assert embedded_file.pdf_object[NameObject("/F")] == NullObject() assert embedded_file.pdf_object[NameObject("/UF")] == NullObject() assert embedded_file.alternative_name is None def test_embedded_file__description_setter(): writer = PdfWriter() embedded_file = writer.add_attachment("test.txt", b"content") embedded_file.description = TextStringObject("Test Description") assert embedded_file.description == "Test Description" embedded_file.description = None assert embedded_file.pdf_object[NameObject("/Desc")] == NullObject() pdf_string = TextStringObject("PDF Description") embedded_file.description = pdf_string assert embedded_file.description == "PDF Description" def test_embedded_file__subtype_setter(): writer = PdfWriter() embedded_file = writer.add_attachment("test.txt", b"content") embedded_file.subtype = NameObject("/text/plain") assert embedded_file.subtype == "/text/plain" embedded_file.subtype = None assert embedded_file._embedded_file[NameObject("/Subtype")] == NullObject() name_obj = NameObject("/application#2Fjson") embedded_file.subtype = name_obj assert embedded_file.subtype == "/application#2Fjson" def test_embedded_file__content_setter(): writer = PdfWriter() embedded_file = writer.add_attachment("test.txt", b"content") assert embedded_file.content == b"content" embedded_file.content = b"Hello World!" assert embedded_file.content == b"Hello World!" embedded_file.content = "Lorem ipsum dolor sit amet" assert embedded_file.content == b"Lorem ipsum dolor sit amet" def test_embedded_file__size_setter(): writer = PdfWriter() embedded_file = writer.add_attachment("test.txt", b"content") embedded_file.size = NumberObject(1024) assert embedded_file.size == 1024 embedded_file.size = None assert embedded_file._ensure_params[NameObject("/Size")] == NullObject() num_obj = NumberObject(2048) embedded_file.size = num_obj assert embedded_file.size == 2048 def test_embedded_file__size_getter(): writer = PdfWriter() embedded_file = writer.add_attachment("test.txt", b"content") embedded_file._ensure_params[NameObject("/Size")] = NullObject() assert embedded_file.size is None embedded_file._ensure_params[NameObject("/Size")] = NumberObject(4096) retrieved_size = embedded_file.size assert retrieved_size == 4096 def test_embedded_file__creation_date_setter(): writer = PdfWriter() embedded_file = writer.add_attachment("test.txt", b"content") test_date = datetime.datetime(2023, 1, 1, 12, 0, 0) embedded_file.creation_date = test_date assert embedded_file.creation_date == test_date embedded_file.creation_date = None assert embedded_file._ensure_params[NameObject("/CreationDate")] == NullObject() def test_embedded_file__modification_date_setter(): writer = PdfWriter() embedded_file = writer.add_attachment("test.txt", b"content") test_date = datetime.datetime(2023, 1, 2, 12, 0, 0) embedded_file.modification_date = test_date assert embedded_file.modification_date == test_date embedded_file.modification_date = None assert embedded_file._ensure_params[NameObject("/ModDate")] == NullObject() def test_embedded_file__checksum_setter(): writer = PdfWriter() embedded_file = writer.add_attachment("test.txt", b"content") checksum_bytes = ByteStringObject(b"checksum_value") embedded_file.checksum = checksum_bytes assert embedded_file.checksum == b"checksum_value" embedded_file.checksum = None assert embedded_file._ensure_params[NameObject("/CheckSum")] == NullObject() byte_string = ByteStringObject(b"pdf_checksum") embedded_file.checksum = byte_string assert embedded_file.checksum == b"pdf_checksum" def test_embedded_file__associated_file_relationship_setter(): writer = PdfWriter() embedded_file = writer.add_attachment("test.txt", b"content") embedded_file.associated_file_relationship = NameObject("/Data") assert embedded_file.associated_file_relationship == "/Data" def test_embedded_file__setters_integration(): writer = PdfWriter() writer.add_blank_page(100, 100) embedded_file = writer.add_attachment("test.txt", b"Hello, World!") embedded_file.alternative_name = TextStringObject("Alternative Name") embedded_file.description = TextStringObject("Test Description") embedded_file.subtype = NameObject("/text/plain") embedded_file.size = NumberObject(13) creation_date = datetime.datetime(2023, 1, 1, 12, 0, 0) embedded_file.creation_date = creation_date modification_date = datetime.datetime(2023, 1, 2, 12, 0, 0) embedded_file.modification_date = modification_date embedded_file.checksum = ByteStringObject(b"checksum123") embedded_file.associated_file_relationship = NameObject(AFRelationship.DATA) # Make sure that this is an indirect object for PDF/A-3 compliance. assert embedded_file.pdf_object.indirect_reference == IndirectObject(6, 0, writer) pdf_bytes = BytesIO() writer.write(pdf_bytes) reader = PdfReader(pdf_bytes) assert "test.txt" in reader.attachments def test_embedded_file__null_object_handling(): writer = PdfWriter() embedded_file = writer.add_attachment("test.txt", b"content") embedded_file.alternative_name = TextStringObject("Name") embedded_file.description = TextStringObject("Description") embedded_file.subtype = NameObject("/text/plain") embedded_file.size = NumberObject(1024) embedded_file.checksum = ByteStringObject(b"checksum") embedded_file.alternative_name = None embedded_file.description = None embedded_file.subtype = None embedded_file.size = None embedded_file.checksum = None assert embedded_file.alternative_name is None assert embedded_file.description is None assert embedded_file.subtype is None assert embedded_file.size is None assert embedded_file.checksum is None def test_embedded_file__delete_without_parent(): attachment = EmbeddedFile(name="test.txt", pdf_object=DictionaryObject()) with pytest.raises(PyPdfError, match=r"^Parent required to delete file from document\.$"): attachment.delete() def test_embedded_file__delete_known(): writer = PdfWriter() writer.add_blank_page(100, 100) attachment = writer.add_attachment("test.txt", b"content") writer.add_attachment("test2.txt", b"content2") attachments = list(writer.attachment_list) assert len(attachments) == 2 attachment.delete() with pytest.raises(PdfReadError, match=r"^/EF entry not found: {}$"): _ = attachment.content attachments = list(writer.attachment_list) assert len(attachments) == 1 assert attachments[0].name == "test2.txt" # Delete second time. with pytest.raises(PyPdfError, match=r"^File not found in parent object\.$"): attachment.delete() def test_embedded_file__delete__no_indirect_reference(): writer = PdfWriter() writer.add_blank_page(100, 100) # Add an attachment and replace the indirect reference in the name tree # by the dictionary itself. This is how pypdf <= 6.1.0 would embed files # and thus should be supported as well. embedded_file = writer.add_attachment("test.txt", b"Hello, World!") assert embedded_file.pdf_object.indirect_reference == IndirectObject(6, 0, writer) embedded_file._parent[-1] = embedded_file.pdf_object.get_object() embedded_file.delete() attachments = list(writer.attachment_list) assert len(attachments) == 0 @pytest.mark.enable_socket def test_embedded_file__create__kids_based_name_tree(): """Test for issue #3473.""" url = "https://github.com/user-attachments/files/18691309/embedded_files_kids.pdf" name = "embedded_files_kids.pdf" writer = PdfWriter(clone_from=BytesIO(get_data_from_url(url, name=name))) writer.add_attachment("test.pdf", b"content") assert dict(writer.attachments) == { "factur-x.xml": [ ( b"Hello World!\n\nLorem ipsum dolor sit amet, consetetur sad" b"ipscing elitr, sed diam nonumy eirmod tempor\ninvidunt ut" b" labore et dolore magna aliquyam erat, sed diam voluptua" b". At vero eos et accusam\net justo duo dolores et ea rebu" b"m. Stet clita kasd gubergren, no sea takimata sanctus es" b"t Lorem\nipsum dolor sit amet. Lorem ipsum dolor sit amet" b", consetetur sadipscing elitr, sed diam\nnonumy eirmod te" b"mpor invidunt ut labore et dolore magna aliquyam erat, s" b"ed diam voluptua.\nAt vero eos et accusam et justo duo do" b"lores et ea rebum. Stet clita kasd gubergren, no sea\ntak" b"imata sanctus est Lorem ipsum dolor sit amet.\n" ) ], "test.pdf": [b"content"] } attachments = list(writer.attachment_list) assert len(attachments) == 2 assert writer.root_object["/Names"]["/EmbeddedFiles"]["/Names"] == [ "factur-x.xml", attachments[0].pdf_object.indirect_reference, "test.pdf", attachments[1].pdf_object.indirect_reference, ] def test_embedded_file__create__neither_kids_nor_names(): writer = PdfWriter() writer.add_blank_page(100, 100) # Add an attachment and remove the corresponding /Names key. writer.add_attachment("test.txt", b"Hello, World!") del writer.root_object["/Names"]["/EmbeddedFiles"]["/Names"] with pytest.raises(expected_exception=PdfReadError, match=r"^Got neither Names nor Kids in embedded files tree\.$"): writer.add_attachment("test2.txt", b"content2") def test_embedded_file__get_insertion_index(): # Empty list. assert EmbeddedFile._get_insertion_index(ArrayObject(), "test.txt") == 0 # One mismatching entry. assert EmbeddedFile._get_insertion_index( ArrayObject([TextStringObject("dummy.txt"), NullObject()]), "test.txt" ) == 2 assert EmbeddedFile._get_insertion_index( ArrayObject([TextStringObject("xxx.txt"), NullObject()]), "test.txt" ) == 0 # Multiple entries. assert EmbeddedFile._get_insertion_index( ArrayObject([TextStringObject("dummy.txt"), NullObject(), TextStringObject("xxx.txt"), NullObject()]), "test.txt" ) == 2 assert EmbeddedFile._get_insertion_index( ArrayObject([TextStringObject("xxx.txt"), NullObject(), TextStringObject("yyy.txt"), NullObject()]), "test.txt" ) == 0 assert EmbeddedFile._get_insertion_index( ArrayObject([TextStringObject("aaa.txt"), NullObject(), TextStringObject("bbb.txt"), NullObject()]), "test.txt" ) == 4 assert EmbeddedFile._get_insertion_index( ArrayObject([ TextStringObject("aaa.txt"), NullObject(), TextStringObject("test.txt"), NullObject(), TextStringObject("zzz.txt"), NullObject() ]), "test.txt" ) == 4 # Length. assert EmbeddedFile._get_insertion_index( ArrayObject([TextStringObject("a"), NullObject()]), "aa" ) == 2 assert EmbeddedFile._get_insertion_index( ArrayObject([TextStringObject("a"), NullObject()]), "a" ) == 2 assert EmbeddedFile._get_insertion_index( ArrayObject([TextStringObject("aaa"), NullObject()]), "aa" ) == 0 # Special characters. assert EmbeddedFile._get_insertion_index( ArrayObject([TextStringObject("cafĂ©"), NullObject()]), "cafe" ) == 0 assert EmbeddedFile._get_insertion_index( ArrayObject([TextStringObject("Tun"), NullObject()]), "TĂĽr" ) == 2 def test_embedded_file__order(): writer = PdfWriter() writer.add_blank_page(100, 100) attachment1 = writer.add_attachment("test.txt", "content") attachment2 = writer.add_attachment("abc.txt", "content") attachment3 = writer.add_attachment("xyz.txt", "content") attachment4 = writer.add_attachment("test.txt", "content2") assert dict(writer.attachments) == { "abc.txt": [b"content"], "test.txt": [b"content", b"content2"], "xyz.txt": [b"content"] } assert writer.root_object["/Names"]["/EmbeddedFiles"]["/Names"] == [ "abc.txt", attachment2.pdf_object.indirect_reference, "test.txt", attachment1.pdf_object.indirect_reference, "test.txt", attachment4.pdf_object.indirect_reference, "xyz.txt", attachment3.pdf_object.indirect_reference, ] pypdf-6.1.2/tests/generic/test_image_inline.py000066400000000000000000000034331507516550200214620ustar00rootroot00000000000000"""Test the pypdf.generic._image_inline module.""" from io import BytesIO from pypdf.generic._image_inline import is_followed_by_binary_data def test_is_followed_by_binary_data(): # Empty/too short stream. stream = BytesIO() assert not is_followed_by_binary_data(stream) stream = BytesIO(b" q\n") assert not is_followed_by_binary_data(stream) # byte < 32 and no whitespace. stream = BytesIO(b"\x00\x11\x13\x37") assert is_followed_by_binary_data(stream) assert stream.read(1) == b"\x00" assert is_followed_by_binary_data(stream) assert stream.read(1) == b"\x11" assert is_followed_by_binary_data(stream) assert stream.read() == b"\x13\x37" # byte < 32, but whitespace. stream = BytesIO(b" q\n") assert not is_followed_by_binary_data(stream) # Whitespace only. stream = BytesIO(b" \n\n\n \n") assert not is_followed_by_binary_data(stream) # No `operator_end`. stream = BytesIO(b"\n\n\n\n\n\n\n\nBT\n") assert not is_followed_by_binary_data(stream) # Operator length is <= 3. stream = BytesIO(b"\n\n\n\n\n\n\nBT\n") assert not is_followed_by_binary_data(stream) # Operator length is > 3. stream = BytesIO(b"\n\n\n\n\nTEST\n") assert is_followed_by_binary_data(stream) # Just characters. stream = BytesIO(b" ABCDEF") assert is_followed_by_binary_data(stream) # No `operator_start`. stream = BytesIO(b"ABCDEFG") assert is_followed_by_binary_data(stream) # Name object. stream = BytesIO(b"/R10 gs\n/R12 cs\n") assert not is_followed_by_binary_data(stream) # Numbers. stream = BytesIO(b"1337 42 m\n") assert not is_followed_by_binary_data(stream) stream = BytesIO(b"1234.56 42 13 37 10 20 c\n") assert not is_followed_by_binary_data(stream) pypdf-6.1.2/tests/scripts/000077500000000000000000000000001507516550200155015ustar00rootroot00000000000000pypdf-6.1.2/tests/scripts/__init__.py000066400000000000000000000000001507516550200176000ustar00rootroot00000000000000pypdf-6.1.2/tests/scripts/data/000077500000000000000000000000001507516550200164125ustar00rootroot00000000000000pypdf-6.1.2/tests/scripts/data/commits__version_4_0_1.json000066400000000000000000000643311507516550200235550ustar00rootroot00000000000000[ { "sha": "b7bfd0d7eddfd0865a94cc9e7027df6596242cf7", "node_id": "C_kwDOAC-ZndoAKGI3YmZkMGQ3ZWRkZmQwODY1YTk0Y2M5ZTcwMjdkZjY1OTYyNDJjZjc", "commit": { "author": { "name": "rsinger417", "email": "159086296+rsinger417@users.noreply.github.com", "date": "2024-02-13T21:42:56Z" }, "committer": { "name": "GitHub", "email": "noreply@github.com", "date": "2024-02-13T21:42:56Z" }, "message": "BUG: Use NumberObject for /Border elements of annotations (#2451)\n\nAs defined in Table 164 – Entries common to all annotation dictionaries, the /Border Array consists of NumberObjects. 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"https://api.github.com/users/web-flow/events{/privacy}", "received_events_url": "https://api.github.com/users/web-flow/received_events", "type": "User", "site_admin": false }, "parents": [ { "sha": "757932944f54ba661b89e0629ed3fc9d8345dbab", "url": "https://api.github.com/repos/py-pdf/pypdf/commits/757932944f54ba661b89e0629ed3fc9d8345dbab", "html_url": "https://github.com/py-pdf/pypdf/commit/757932944f54ba661b89e0629ed3fc9d8345dbab" } ] } ] pypdf-6.1.2/tests/scripts/test_make_release.py000066400000000000000000000143271507516550200215360ustar00rootroot00000000000000"""Test the `make_release.py` script.""" import sys from pathlib import Path from unittest import mock import pytest DATA_PATH = Path(__file__).parent.resolve() / "data" # line starting with \ and ending with " have been observed on windows GIT_LOG__VERSION_4_0_1 = """ b7bfd0d7eddfd0865a94cc9e7027df6596242cf7:::BUG: Use NumberObject for /Border elements of annotations (#2451):::rsinger417 8cacb0fc8fee9920b0515d1289e6ee8191eb3f21:::DOC: Document easier way to update metadata (#2454):::Stefan 3fb63f7e3839ce39ac98978c996f3086ba230a20:::TST: Avoid catching not emitted warnings (#2429):::Stefan \\61b73d49778e8f0fb172d5323e67677c9974e420:::DOC: Typo `Polyline` → `PolyLine` in adding-pdf-annotations.md (#2426):::CWKSC" f851a532a5ec23b572d86bd7185b327a3fac6b58:::DEV: Bump codecov/codecov-action from 3 to 4 (#2430):::dependabot[bot]""".encode() # noqa: E501 COMMITS__VERSION_4_0_1 = DATA_PATH.joinpath("commits__version_4_0_1.json") VERSION_3_9_PLUS = sys.version_info[:2] >= (3, 9) @pytest.mark.skipif(not VERSION_3_9_PLUS, reason="Function uses method removeprefix added in Python 3.9") @pytest.mark.parametrize( ("data", "expected"), [ ("", ""), ("# CHANGELOG", ""), ("# CHANGELOG ", ""), ("# CHANGELOG ", ""), ("## CHANGELOG", "## CHANGELOG"), ("CHANGELOG", "CHANGELOG"), ("# CHANGELOG #", "#"), ] ) def test_strip_header(data, expected): """Removal of the 'CHANGELOG' header.""" make_release = pytest.importorskip("make_release") assert make_release.strip_header(data) == expected def test_get_git_commits_since_tag(): make_release = pytest.importorskip("make_release") with open(COMMITS__VERSION_4_0_1, mode="rb") as commits, mock.patch( "urllib.request.urlopen", side_effect=lambda _: commits ), mock.patch("subprocess.check_output", return_value=GIT_LOG__VERSION_4_0_1): commits = make_release.get_git_commits_since_tag("4.0.1") assert commits == [ make_release.Change( commit_hash="b7bfd0d7eddfd0865a94cc9e7027df6596242cf7", prefix="BUG", message="Use NumberObject for /Border elements of annotations (#2451)", author="rsinger417", author_login="rsinger417", ), make_release.Change( commit_hash="8cacb0fc8fee9920b0515d1289e6ee8191eb3f21", prefix="DOC", message="Document easier way to update metadata (#2454)", author="Stefan", author_login="stefan6419846", ), make_release.Change( commit_hash="3fb63f7e3839ce39ac98978c996f3086ba230a20", prefix="TST", message="Avoid catching not emitted warnings (#2429)", author="Stefan", author_login="stefan6419846", ), make_release.Change( commit_hash="61b73d49778e8f0fb172d5323e67677c9974e420", prefix="DOC", message="Typo `Polyline` → `PolyLine` in adding-pdf-annotations.md (#2426)", author="CWKSC", author_login="CWKSC", ), make_release.Change( commit_hash="f851a532a5ec23b572d86bd7185b327a3fac6b58", prefix="DEV", message="Bump codecov/codecov-action from 3 to 4 (#2430)", author="dependabot[bot]", author_login="dependabot[bot]", ), ] def test_get_formatted_changes(): make_release = pytest.importorskip("make_release") with open(COMMITS__VERSION_4_0_1, mode="rb") as commits, mock.patch( "urllib.request.urlopen", side_effect=lambda _: commits ), mock.patch("subprocess.check_output", return_value=GIT_LOG__VERSION_4_0_1): output, output_with_user = make_release.get_formatted_changes("4.0.1") assert ( output == """ ### Bug Fixes (BUG) - Use NumberObject for /Border elements of annotations (#2451) ### Documentation (DOC) - Document easier way to update metadata (#2454) - Typo `Polyline` → `PolyLine` in adding-pdf-annotations.md (#2426) ### Developer Experience (DEV) - Bump codecov/codecov-action from 3 to 4 (#2430) ### Testing (TST) - Avoid catching not emitted warnings (#2429) """ ) assert ( output_with_user == """ ### Bug Fixes (BUG) - Use NumberObject for /Border elements of annotations (#2451) by @rsinger417 ### Documentation (DOC) - Document easier way to update metadata (#2454) by @stefan6419846 - Typo `Polyline` → `PolyLine` in adding-pdf-annotations.md (#2426) by @CWKSC ### Developer Experience (DEV) - Bump codecov/codecov-action from 3 to 4 (#2430) by @dependabot[bot] ### Testing (TST) - Avoid catching not emitted warnings (#2429) by @stefan6419846 """ ) def test_get_formatted_changes__other(): make_release = pytest.importorskip("make_release") changes = [ make_release.Change( commit_hash="f20c36eabd59ea661f30c5da35af7c9e435c7de9", prefix="", message="Improve lossless compression example (#2488)", author="j-t-1", author_login="j-t-1", ), make_release.Change( commit_hash="afbee382f8fd2b39588db6470b9b2b2c82905318", prefix="ENH", message="Add reattach_fields function (#2480)", author="pubpub-zz", author_login="pubpub-zz", ), make_release.Change( commit_hash="cd705f959064d8125397ddf4f7bdd2ea296f889f", prefix="FIX", message="Broken test due to expired test file URL (#2468)", author="pubpub-zz", author_login="pubpub-zz", ), ] with mock.patch.object( make_release, "get_git_commits_since_tag", return_value=changes ): output, output_with_user = make_release.get_formatted_changes("dummy") assert ( output == """ ### New Features (ENH) - Add reattach_fields function (#2480) ### Other - : Improve lossless compression example (#2488) - FIX: Broken test due to expired test file URL (#2468) """ ) assert ( output_with_user == """ ### New Features (ENH) - Add reattach_fields function (#2480) by @pubpub-zz ### Other - : Improve lossless compression example (#2488) by @j-t-1 - FIX: Broken test due to expired test file URL (#2468) by @pubpub-zz """ ) pypdf-6.1.2/tests/test_annotations.py000066400000000000000000000241261507516550200177650ustar00rootroot00000000000000"""Test the pypdf.annotations submodule.""" from io import BytesIO from pathlib import Path import pytest from pypdf import PdfReader, PdfWriter from pypdf.annotations import ( AnnotationDictionary, Ellipse, FreeText, Highlight, Line, Link, Polygon, PolyLine, Popup, Rectangle, Text, ) from pypdf.errors import PdfReadError from pypdf.generic import ArrayObject, FloatObject, NumberObject from . import get_data_from_url TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" def test_ellipse(pdf_file_path): # Arrange pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) # Act ellipse_annotation = Ellipse( rect=(50, 550, 500, 650), interior_color="ff0000", ) writer.add_annotation(0, ellipse_annotation) # Assert: You need to inspect the file manually with open(pdf_file_path, "wb") as fp: writer.write(fp) def test_text(pdf_file_path): # Arrange pdf_path = RESOURCE_ROOT / "outline-without-title.pdf" reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) # Act text_annotation = Text( text="Hello World\nThis is the second line!", rect=(50, 550, 500, 650), open=True, ) writer.add_annotation(0, text_annotation) # Assert: You need to inspect the file manually with open(pdf_file_path, "wb") as fp: writer.write(fp) def test_free_text(pdf_file_path): # Arrange pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) # Act free_text_annotation = FreeText( text="Hello World - bold and italic\nThis is the second line!", rect=(50, 550, 200, 650), font="Arial", bold=True, italic=True, font_size="20pt", font_color="00ff00", border_color=None, background_color=None, ) writer.add_annotation(0, free_text_annotation) free_text_annotation = FreeText( text="Another free text annotation (not bold, not italic)", rect=(500, 550, 200, 650), font="Arial", bold=False, italic=False, font_size="20pt", font_color="00ff00", border_color="0000ff", background_color="cdcdcd", ) writer.add_annotation(0, free_text_annotation) # Assert: You need to inspect the file manually with open(pdf_file_path, "wb") as fp: writer.write(fp) def test_free_text__font_specifier(): free_text_annotation = FreeText( text="Hello World", rect=(0, 0, 0, 0), ) assert free_text_annotation["/DS"] == "font: normal normal 14pt Helvetica;text-align:left;color:#000000" free_text_annotation = FreeText( text="Hello World", rect=(50, 550, 200, 650), font="Arial", bold=True, italic=True, font_size="20pt", font_color="00ff00", border_color=None, background_color=None, ) assert free_text_annotation["/DS"] == "font: italic bold 20pt Arial;text-align:left;color:#00ff00" def test_annotation_dictionary(): a = AnnotationDictionary() a.flags = 123 assert a.flags == 123 def test_polygon(pdf_file_path): # Arrange pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) with pytest.raises(ValueError): Polygon( vertices=[], ) annotation = Polygon( vertices=[(50, 550), (200, 650), (70, 750), (50, 700)], ) writer.add_annotation(0, annotation) # Assert: You need to inspect the file manually with open(pdf_file_path, "wb") as fp: writer.write(fp) def test_polyline(pdf_file_path): # Arrange pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) with pytest.raises(ValueError): PolyLine( vertices=[], ) annotation = PolyLine( vertices=[(50, 550), (200, 650), (70, 750), (50, 700)], ) writer.add_annotation(0, annotation) # Assert: You need to inspect the file manually with open(pdf_file_path, "wb") as fp: writer.write(fp) def test_line(pdf_file_path): # Arrange pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) # Act line_annotation = Line( text="Hello World\nLine2", rect=(50, 550, 200, 650), p1=(50, 550), p2=(200, 650), ) writer.add_annotation(0, line_annotation) # Assert: You need to inspect the file manually with open(pdf_file_path, "wb") as fp: writer.write(fp) def test_rectangle(pdf_file_path): # Arrange pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) # Act square_annotation = Rectangle( rect=(50, 550, 200, 650), interior_color="ff0000" ) writer.add_annotation(0, square_annotation) square_annotation = Rectangle(rect=(40, 400, 150, 450)) writer.add_annotation(0, square_annotation) # Assert: You need to inspect the file manually with open(pdf_file_path, "wb") as fp: writer.write(fp) def test_highlight(pdf_file_path): # Arrange pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) # Act highlight_annotation = Highlight( rect=(95.79332, 704.31777, 138.55779, 724.6855), highlight_color="ff0000", quad_points=ArrayObject( [ FloatObject(100.060779), FloatObject(723.55398), FloatObject(134.29033), FloatObject(723.55398), FloatObject(100.060779), FloatObject(705.4493), FloatObject(134.29033), FloatObject(705.4493), ] ), printing=False, ) writer.add_annotation(0, highlight_annotation) for annot in writer.pages[0]["/Annots"]: obj = annot.get_object() subtype = obj["/Subtype"] if subtype == "/Highlight": assert "/F" not in obj or obj["/F"] == NumberObject(0) writer.add_page(page) # Act highlight_annotation = Highlight( rect=(95.79332, 704.31777, 138.55779, 724.6855), highlight_color="ff0000", quad_points=ArrayObject( [ FloatObject(100.060779), FloatObject(723.55398), FloatObject(134.29033), FloatObject(723.55398), FloatObject(100.060779), FloatObject(705.4493), FloatObject(134.29033), FloatObject(705.4493), ] ), printing=True, ) writer.add_annotation(1, highlight_annotation) for annot in writer.pages[1]["/Annots"]: obj = annot.get_object() subtype = obj["/Subtype"] if subtype == "/Highlight": assert obj["/F"] == NumberObject(4) # Assert: You need to inspect the file manually with open(pdf_file_path, "wb") as fp: writer.write(fp) def test_link(pdf_file_path): # Arrange pdf_path = RESOURCE_ROOT / "outline-without-title.pdf" reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) # Act # Part 1: Too many args with pytest.raises(ValueError): Link( rect=(50, 550, 200, 650), url="https://martin-thoma.com/", target_page_index=3, ) # Part 2: Too few args with pytest.raises(ValueError): Link( rect=(50, 550, 200, 650), ) # Part 3: External Link link_annotation = Link( rect=(50, 50, 100, 100), url="https://martin-thoma.com/", border=[1, 0, 6, [3, 2]], ) writer.add_annotation(0, link_annotation) # Part 4: Internal Link link_annotation = Link( rect=(100, 100, 300, 200), target_page_index=1, border=[50, 10, 4], ) writer.add_annotation(0, link_annotation) for page in reader.pages[1:]: writer.add_page(page) # Assert: You need to inspect the file manually with open(pdf_file_path, "wb") as fp: writer.write(fp) def test_popup(caplog): # Arrange pdf_path = RESOURCE_ROOT / "outline-without-title.pdf" reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) # Act text_annotation = Text( title_bar="hello world", text="Hello World\nThis is the second line!", rect=(50, 550, 200, 650), open=True, ) ta = writer.add_annotation(0, text_annotation) popup_annotation = Popup( rect=(50, 550, 200, 650), open=True, parent=ta, # prefer to use for evolutivity ) writer.add_annotation(writer.pages[0], popup_annotation) Popup( rect=(50, 550, 200, 650), open=True, parent=True, # broken parameter # type: ignore ) assert "Unregistered Parent object : No Parent field set" in caplog.text target = "annotated-pdf-popup.pdf" writer.write(target) Path(target).unlink() # comment this out for manual inspection @pytest.mark.enable_socket def test_outline_action_without_d_lenient(): reader = PdfReader(BytesIO(get_data_from_url(name="iss3268.pdf"))) assert len(reader.outline) == 2 @pytest.mark.enable_socket def test_outline_action_without_d_strict(pdf_file_path): reader = PdfReader(BytesIO(get_data_from_url(name="iss3268.pdf"))) reader.strict = True with pytest.raises(PdfReadError) as e: assert len(reader.outline) == 2 assert "Outline Action Missing /D" in str(e) pypdf-6.1.2/tests/test_cmap.py000066400000000000000000000244701507516550200163520ustar00rootroot00000000000000"""Test the pypdf_cmap module.""" from io import BytesIO from pathlib import Path import pytest from pypdf import PdfReader, PdfWriter from pypdf._cmap import build_char_map, get_encoding, parse_bfchar from pypdf._codecs import charset_encoding from pypdf.generic import ArrayObject, DictionaryObject, IndirectObject, NameObject, NullObject from . import get_data_from_url TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" @pytest.mark.enable_socket @pytest.mark.slow @pytest.mark.parametrize( ("url", "name", "strict"), [ # compute_space_width: ( None, "tika-923406.pdf", False, ), # _parse_to_unicode_process_rg: ( None, "tika-959173.pdf", False, ), ( None, "tika-959173.pdf", True, ), # issue #1718: ( None, "iss1718.pdf", False, ), ], ) def test_text_extraction_slow(caplog, url: str, name: str, strict: bool): reader = PdfReader(BytesIO(get_data_from_url(url, name=name)), strict=strict) for page in reader.pages: page.extract_text() assert caplog.text == "" @pytest.mark.enable_socket @pytest.mark.parametrize( ("url", "name", "strict"), [ # bfchar_on_2_chars: issue #1293 ( None, "ASurveyofImageClassificationBasedTechniques.pdf", False, ), # L40, get_font_width_from_default ( None, "tika-908104.pdf", False, ), # multiline_bfrange / regression test for issue #1285: ( None, "The%20lean%20times%20in%20the%20Peruvian%20economy.pdf", False, ), ( None, "Giacalone.pdf", False, ), ], ) def test_text_extraction_fast(caplog, url: str, name: str, strict: bool): """Text extraction runs without exceptions or warnings""" reader = PdfReader(BytesIO(get_data_from_url(url, name=name)), strict=strict) for page in reader.pages: page.extract_text() assert caplog.text == "" @pytest.mark.enable_socket def test_parse_encoding_advanced_encoding_not_implemented(caplog): reader = PdfReader(BytesIO(get_data_from_url(name="tika-957144.pdf"))) for page in reader.pages: page.extract_text() # The correctly spelled encoding is /WinAnsiEncoding assert "Advanced encoding /WinAnsEncoding not implemented yet" in caplog.text @pytest.mark.enable_socket def test_ascii_charset(): # Issue #1312 reader = PdfReader(BytesIO(get_data_from_url(name="ascii charset.pdf"))) assert "/a" not in reader.pages[0].extract_text() @pytest.mark.enable_socket @pytest.mark.parametrize( ("url", "name", "page_nb", "within_text"), [ ( None, "cmap1370.pdf", 0, "", ), ( None, "02voc.pdf", 2, "Document delineation and character sequence decoding", ), ], ids=["iss1370", "iss1379"], ) def test_text_extraction_of_specific_pages( url: str, name: str, page_nb: int, within_text ): reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert within_text in reader.pages[page_nb].extract_text() @pytest.mark.enable_socket def test_iss1533(): reader = PdfReader(BytesIO(get_data_from_url(name="iss1533.pdf"))) reader.pages[0].extract_text() # no error assert build_char_map("/F", 200, reader.pages[0])[3]["\x01"] == "Ăś" @pytest.mark.enable_socket @pytest.mark.parametrize( ("url", "name", "page_index", "within_text", "caplog_text"), [ ( None, "tstUCS2.pdf", 1, ["2 / 12", "S0490520090001", "于博"], "", ), ( None, "tst-GBK_EUC.pdf", 0, ["NJA", "中华男科学杂志"], "Multiple definitions in dictionary at byte 0x5cb42 for key /MediaBox\n", ), ], ) def test_cmap_encodings(caplog, url, name, page_index, within_text, caplog_text): reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) extracted = reader.pages[page_index].extract_text() # no error for contained in within_text: assert contained in extracted assert caplog_text in caplog.text @pytest.mark.enable_socket def test_latex(): reader = PdfReader(BytesIO(get_data_from_url(name="math_latex.pdf"))) txt = reader.pages[0].extract_text() # no error for pat in ("α", "β", "Îł", "Ď•", "φ", "â„Ź", "â«", "â‚", "·", "Ă—"): assert pat in txt # actually the Ď• and φ seems to be crossed in latex @pytest.mark.enable_socket def test_unixxx_glyphs(): reader = PdfReader(BytesIO(get_data_from_url(name="unixxx_glyphs.pdf"))) txt = reader.pages[0].extract_text() # no error for pat in ("闫耀庭", "éľšéľ‘", "张江水", "1′′.2"): assert pat in txt @pytest.mark.enable_socket def test_cmap_compute_space_width(): # issue 2137 # original file URL: # url = "https://arxiv.org/pdf/2005.05909.pdf" # URL from github issue is too long to pass code type check, use original arxiv URL instead # url = "https://github.com/py-pdf/pypdf/files/12489914/Morris.et.al.-.2020.-.TextAttack.A.Framework.for.Adversarial.Attacks.Data.Augmentation.and.Adversarial.Training.in.NLP.pdf" reader = PdfReader(BytesIO(get_data_from_url(name="TextAttack_paper.pdf"))) reader.pages[0].extract_text() # no error @pytest.mark.enable_socket def test_tabs_in_cmap(): """Issue #2173""" reader = PdfReader(BytesIO(get_data_from_url(name="iss2173.pdf"))) reader.pages[0].extract_text() @pytest.mark.enable_socket def test_ignoring_non_put_entries(): """Issue #2290""" reader = PdfReader(BytesIO(get_data_from_url(name="iss2290.pdf"))) reader.pages[0].extract_text() @pytest.mark.enable_socket def test_eten_b5(): """Issue #2356""" reader = PdfReader(BytesIO(get_data_from_url(name="iss2290.pdf"))) reader.pages[0].extract_text().startswith("1/7 \n富邦新終身壽險") def test_missing_entries_in_cmap(): """ Issue #2702: this issue is observed on damaged pdfs use of this file in test has been discarded as too slow/long we will create the same error from crazyones """ pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) p = reader.pages[0] p["/Resources"]["/Font"]["/F1"][NameObject("/ToUnicode")] = IndirectObject( 99999999, 0, reader ) p.extract_text() def test_null_missing_width(): """For coverage of #2792""" writer = PdfWriter(RESOURCE_ROOT / "crazyones.pdf") page = writer.pages[0] ft = page["/Resources"]["/Font"]["/F1"] ft[NameObject("/Widths")] = ArrayObject() ft["/FontDescriptor"][NameObject("/MissingWidth")] = NullObject() page.extract_text() @pytest.mark.enable_socket def test_unigb_utf16(): """Cf #2812""" url = ( "https://github.com/user-attachments/files/16767536/W020240105322424121296.pdf" ) name = "iss2812.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert "《中国č˝ćşĺ±•ćś› 2060ďĽ2024 ĺą´ç‰ďĽ‰ă€‹çĽ–写委ĺ‘会" in reader.pages[1].extract_text() @pytest.mark.enable_socket def test_too_many_differences(): """Cf #2836""" url = ( "https://github.com/user-attachments/files/16911741/dumb_extract_text_crash.pdf" ) name = "iss2836.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert reader.pages[0].extract_text() == "" @pytest.mark.enable_socket def test_iss2925(): url = ( "https://github.com/user-attachments/files/17621508/2305.09315.pdf" ) name = "iss2925.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert "slicing on the PDG to extract the relevant contextual" in reader.pages[3].extract_text() @pytest.mark.enable_socket def test_iss2966(): """Regression test for issue #2966: indirect objects in fonts""" url = ( "https://github.com/user-attachments/files/17904233/repro_out.pdf" ) name = "iss2966.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert "Lorem ipsum dolor sit amet" in reader.pages[0].extract_text() @pytest.mark.enable_socket def test_binascii_odd_length_string(caplog): """Tests for #2216""" url = "https://github.com/user-attachments/files/18199642/iss2216.pdf" name = "iss2216.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) page = reader.pages[0] assert "\n(Many other theorems may\n" in page.extract_text() assert "Skipping broken line b'143f 143f 10300': Odd-length string\n" in caplog.text @pytest.mark.enable_socket def test_standard_encoding(caplog): """Tests for #3156""" url = "https://github.com/user-attachments/files/18983503/standard-encoding.pdf" name = "issue3156.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) page = reader.pages[0] assert page.extract_text() == "Lorem ipsum" assert "Advanced encoding" not in caplog.text @pytest.mark.enable_socket def test_function_in_font_widths(caplog): """Tests for #3153""" url = "https://github.com/user-attachments/files/18945709/Marseille_pypdf_level_0.2._compressed.pdf" name = "issue3153.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) page = reader.pages[455] assert "La vulnĂ©rabilitĂ© correspond aux consĂ©quences potentielles" in page.extract_text() assert "Expected numeric value for width, got {'/Bounds': [0.25, 0.25]," in caplog.text def test_get_encoding__encoding_value_is_none(): ft = DictionaryObject() ft[NameObject("/Encoding")] = NullObject() assert get_encoding(ft) == ( dict(zip(range(256), charset_encoding["/StandardEncoding"])), {} ) def test_parse_bfchar(caplog): map_dict = {} int_entry = [] parse_bfchar(line=b"057e 1337", map_dict=map_dict, int_entry=int_entry) parse_bfchar(line=b"056e 1f310", map_dict=map_dict, int_entry=int_entry) assert map_dict == {-1: 2, "Ő®": "", "Őľ": "ጷ"} assert int_entry == [1406, 1390] assert caplog.messages == ["Got invalid hex string: Odd-length string (b'1f310')"] pypdf-6.1.2/tests/test_codecs.py000066400000000000000000000254751507516550200167000ustar00rootroot00000000000000"""Test LZW-related code.""" from pathlib import Path import pytest from pypdf._codecs._codecs import LzwCodec from . import get_data_from_url TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" test_cases = [ pytest.param(b"", id="Empty input"), pytest.param(b"A", id="Single character"), pytest.param(b"AAAAAA", id="Repeating character"), pytest.param(b"Hello, World!", id="Simple text"), pytest.param(b"ABABABABABAB", id="Repeating pattern"), pytest.param(b"The quick brown fox jumps over the lazy dog", id="Longer text"), pytest.param(b"\x00\xFF\x00\xFF", id="Binary data"), pytest.param( 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id="Table overflow", ), ] @pytest.mark.parametrize("data", test_cases) def test_encode_decode(data): """Decoder and encoder match.""" codec = LzwCodec() compressed_data = codec.encode(data) decoded = codec.decode(compressed_data) assert decoded == data @pytest.mark.parametrize( ("plain", "expected_encoded"), [ (b"", b"\x80@@"), (b"A", b"\x80\x10` "), (b"AAAAAA", b"\x80\x10`P8\x08"), (b"Hello, World!", b"\x80\x12\x0c\xa6\xc3a\xbcX +\x9b\xceF\xc3 \x86\x02"), ], ) def test_encode_lzw(plain, expected_encoded): codec = LzwCodec() actual_encoded = codec.encode(plain) assert actual_encoded == expected_encoded @pytest.mark.parametrize( ("encoded", "expected_decoded"), [ # _pack_codes_into_bytes([256, 65, 66, 67, 68, 256, 256, 69, 70, 71, 72, 257]) (b"\x80\x10HD2$\x02\x00E#\x11\xc9\x10\x10", b"ABCDEFGH"), # Clear twice. # _pack_codes_into_bytes([65, 66, 67, 68, 257]) (b" \x90\x88dH\x08", b"ABCD"), # No explicit initial clear marker. ], ) def test_decode_lzw(encoded, expected_decoded): codec = LzwCodec() actual_decoded = codec.decode(encoded) assert actual_decoded == expected_decoded def test_lzw_decoder_table_overflow(caplog): path = RESOURCE_ROOT / "lzw_decoder_table_overflow.bin" codec = LzwCodec() assert codec.decode(path.read_bytes()).startswith( b'0123456789abcdefghijklmnopqrstuvwxyzABCDEFGHIJKLMNOPQRSTUVWXYZ!"#$%&\'()*+,-./:;<=>?@' ) assert len(codec.decoding_table) == 4096 assert "Ignoring too large LZW table index." in caplog.text @pytest.mark.enable_socket @pytest.mark.timeout(timeout=15, method="thread") def test_lzw_decoder_large_stream_performance(caplog): LzwCodec().decode(get_data_from_url(name="large_lzw_example_encoded.dat")) pypdf-6.1.2/tests/test_constants.py000066400000000000000000000072551507516550200174500ustar00rootroot00000000000000"""Test the pypdf.constants module.""" import re from typing import Callable import pytest from pypdf.constants import PDF_KEYS, GraphicsStateParameters, UserAccessPermissions def test_slash_prefix(): """ Naming conventions of PDF_KEYS (constant names) are followed. This test function validates if PDF key names follow the required pattern: - Starts with a slash "/" - Followed by an uppercase letter - Contains alphanumeric characters (letters and digits) - The attribute name should be a case-insensitive match, with underscores removed """ pattern = re.compile(r"^\/[A-Z]+[a-zA-Z0-9]*$") for cls in PDF_KEYS: for attr in dir(cls): # Skip magic methods if attr.startswith("__") and attr.endswith("__"): continue # Skip methods constant_value = getattr(cls, attr) if isinstance(constant_value, Callable): continue assert constant_value.startswith("/") assert attr.replace("_", "").casefold() == constant_value[1:].casefold() # There are a few exceptions that may be lowercase if cls == GraphicsStateParameters and attr in ["ca", "op"]: continue assert pattern.match(constant_value) def test_user_access_permissions__dict_handling(): # Value is mix of configurable and reserved bits. # Reserved bits should not be part of the dictionary. as_dict = UserAccessPermissions(512 + 64 + 8).to_dict() assert as_dict == { "add_or_modify": False, "assemble_doc": False, "extract": False, "extract_text_and_graphics": True, "fill_form_fields": False, "modify": True, "print": False, "print_to_representation": False, } # Convert the dictionary back to an integer. # This should add the reserved bits automatically. permissions = UserAccessPermissions.from_dict(as_dict) assert permissions == 4294963912 # Roundtrip for valid dictionary. data = { "add_or_modify": True, "assemble_doc": False, "extract": False, "extract_text_and_graphics": True, "fill_form_fields": False, "modify": True, "print": False, "print_to_representation": True, } assert UserAccessPermissions.from_dict(data).to_dict() == data # Empty inputs. assert UserAccessPermissions.from_dict({}) == 4294963392 # Reserved bits. assert UserAccessPermissions(0).to_dict() == { "add_or_modify": False, "assemble_doc": False, "extract": False, "extract_text_and_graphics": False, "fill_form_fields": False, "modify": False, "print": False, "print_to_representation": False, } # Unknown dictionary keys. data = { "add_or_modify": True, "key1": False, "key2": True, } unknown = { "key1": False, "key2": True, } with pytest.raises( ValueError, match=f"Unknown dictionary keys: {unknown!r}" ): UserAccessPermissions.from_dict(data) def test_user_access_permissions__all(): all_permissions = UserAccessPermissions.all() all_int = int(all_permissions) all_string = bin(all_permissions) assert all_string.startswith("0b") assert len(all_string[2:]) == 32 # 32-bit integer assert all_int & UserAccessPermissions.R1 == 0 assert all_int & UserAccessPermissions.R2 == 0 assert all_int & UserAccessPermissions.PRINT == UserAccessPermissions.PRINT assert all_int & UserAccessPermissions.R7 == UserAccessPermissions.R7 assert all_int & UserAccessPermissions.R31 == UserAccessPermissions.R31 pypdf-6.1.2/tests/test_doc_common.py000066400000000000000000000323671507516550200175530ustar00rootroot00000000000000"""Test the pypdf._doc_common module.""" import itertools import re import shutil import subprocess from io import BytesIO from operator import itemgetter from pathlib import Path from unittest import mock import pytest from pypdf import PdfReader, PdfWriter from pypdf.generic import EmbeddedFile, NullObject, TextStringObject, ViewerPreferences from tests import get_data_from_url TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent SAMPLE_ROOT = PROJECT_ROOT / "sample-files" RESOURCES_ROOT = PROJECT_ROOT / "resources" PDFATTACH_BINARY = shutil.which("pdfattach") @pytest.mark.skipif(PDFATTACH_BINARY is None, reason="Requires poppler-utils") def test_attachments(tmpdir): # No attachments. clean_path = SAMPLE_ROOT / "002-trivial-libre-office-writer" / "002-trivial-libre-office-writer.pdf" with PdfReader(clean_path) as pdf: assert pdf._list_attachments() == [] assert list(pdf.attachment_list) == [] # UF = name. attached_path = tmpdir / "attached.pdf" file_path = tmpdir / "test.txt" file_path.write_binary(b"Hello World\n") subprocess.run([PDFATTACH_BINARY, clean_path, file_path, attached_path]) # noqa: S603 with PdfReader(str(attached_path)) as pdf: assert pdf._list_attachments() == ["test.txt"] assert pdf._get_attachments("test.txt") == {"test.txt": b"Hello World\n"} assert [(x.name, x.content) for x in pdf.attachment_list] == [("test.txt", b"Hello World\n")] assert next(pdf.attachment_list).alternative_name == "test.txt" # UF != name. different_path = tmpdir / "different.pdf" different_path.write_binary(re.sub(rb" /UF [^/]+ /", b" /UF(my-file.txt) /", attached_path.read_binary())) with PdfReader(str(different_path)) as pdf: assert pdf._list_attachments() == ["test.txt", "my-file.txt"] assert pdf._get_attachments("test.txt") == {"test.txt": b"Hello World\n"} assert pdf._get_attachments("my-file.txt") == {"my-file.txt": b"Hello World\n"} assert [(x.name, x.content) for x in pdf.attachment_list] == [("test.txt", b"Hello World\n")] assert next(pdf.attachment_list).alternative_name == "my-file.txt" # Only name. no_f_path = tmpdir / "no-f.pdf" no_f_path.write_binary(re.sub(rb" /UF [^/]+ /", b" /", attached_path.read_binary())) with PdfReader(str(no_f_path)) as pdf: assert pdf._list_attachments() == ["test.txt"] assert pdf._get_attachments("test.txt") == {"test.txt": b"Hello World\n"} assert [(x.name, x.content) for x in pdf.attachment_list] == [("test.txt", b"Hello World\n")] assert next(pdf.attachment_list).alternative_name is None # UF and F. uf_f_path = tmpdir / "uf-f.pdf" uf_f_path.write_binary(attached_path.read_binary().replace(b" /UF ", b"/F(file.txt) /UF ")) with PdfReader(str(uf_f_path)) as pdf: assert pdf._list_attachments() == ["test.txt"] assert pdf._get_attachments("test.txt") == {"test.txt": b"Hello World\n"} assert [(x.name, x.content) for x in pdf.attachment_list] == [("test.txt", b"Hello World\n")] assert next(pdf.attachment_list).alternative_name == "test.txt" # Only F. only_f_path = tmpdir / "f.pdf" only_f_path.write_binary(attached_path.read_binary().replace(b" /UF ", b" /F ")) with PdfReader(str(only_f_path)) as pdf: assert pdf._list_attachments() == ["test.txt"] assert pdf._get_attachments("test.txt") == {"test.txt": b"Hello World\n"} assert [(x.name, x.content) for x in pdf.attachment_list] == [("test.txt", b"Hello World\n")] assert next(pdf.attachment_list).alternative_name == "test.txt" def test_get_attachments__same_attachment_more_than_twice(): writer = PdfWriter() writer.add_blank_page(100, 100) for i in range(5): writer.add_attachment("test.txt", f"content{i}") assert writer._get_attachments("test.txt") == { "test.txt": [b"content0", b"content1", b"content2", b"content3", b"content4"] } assert [(x.name, x.content) for x in writer.attachment_list] == [ ("test.txt", b"content0"), ("test.txt", b"content1"), ("test.txt", b"content2"), ("test.txt", b"content3"), ("test.txt", b"content4"), ] def test_get_attachments__alternative_name_is_none(): writer = PdfWriter() attachment = EmbeddedFile(name="test.txt", pdf_object=writer.root_object) assert attachment.alternative_name is None with mock.patch( "pypdf._writer.PdfWriter.attachment_list", new_callable=mock.PropertyMock(return_value=[attachment]) ), mock.patch( "pypdf.generic._files.EmbeddedFile.content", new_callable=mock.PropertyMock(return_value=b"content") ): assert writer._get_attachments() == {"test.txt": b"content"} @pytest.mark.enable_socket def test_byte_encoded_named_destinations(): url = "https://github.com/user-attachments/files/19820164/pypdf_issue.pdf" name = "issue3261.pdf" reader = PdfReader(BytesIO(get_data_from_url(url=url, name=name))) page = reader.pages[0] for annotation in page.annotations: if annotation.get("/Subtype") == "/Link": action = annotation["/A"] if action["/S"] == "/GoTo": named_dest = action["/D"] assert str(named_dest) in reader.named_destinations assert TextStringObject(named_dest) in reader.named_destinations assert reader.named_destinations == { "Doc-Start": { "/Title": "Doc-Start", "/Page": page.indirect_reference, "/Type": "/XYZ", "/Left": 133.768, "/Top": 667.198, "/Zoom": NullObject() }, "cite.dacĂ\xadk2025racerflightweightstaticdata": { "/Title": "cite.dacĂ\xadk2025racerflightweightstaticdata", "/Page": page.indirect_reference, "/Type": "/XYZ", "/Left": 133.768, "/Top": 614.424, "/Zoom": NullObject() }, # This is the same as the previous entry, but with `str(name)` instead of the title. "楣整ć®ćŤˇę·ă‰«ă°çµćŤˇç‰Ąć±¦ćť©ç‘¨ć•·ćť©ç‘¨ç‘łç‘ˇćŤ©ć…¤ć…´": { "/Left": 133.768, "/Page": page.indirect_reference, "/Title": "cite.dacĂ\xadk2025racerflightweightstaticdata", "/Top": 614.424, "/Type": "/XYZ", "/Zoom": NullObject() }, "page.1": { "/Title": "page.1", "/Page": page.indirect_reference, "/Type": "/XYZ", "/Left": 132.768, "/Top": 705.06, "/Zoom": NullObject() }, "section*.1": { "/Title": "section*.1", "/Page": page.indirect_reference, "/Type": "/XYZ", "/Left": 133.768, "/Top": 642.222, "/Zoom": NullObject() } } def test_viewer_preferences__indirect_reference(): input_path = RESOURCES_ROOT / "git.pdf" reader = PdfReader(input_path) assert (0, 24) not in reader.resolved_objects viewer_preferences = reader.viewer_preferences assert isinstance(viewer_preferences, ViewerPreferences) assert viewer_preferences == {"/DisplayDocTitle": True} assert (0, 24) in reader.resolved_objects assert id(viewer_preferences) == id(reader.viewer_preferences) assert id(viewer_preferences) == id(reader.resolved_objects[(0, 24)]) @pytest.mark.enable_socket def test_named_destinations__tree_is_null_object(): url = "https://github.com/user-attachments/files/20885216/test.pdf" name = "issue3330.pdf" reader = PdfReader(BytesIO(get_data_from_url(url=url, name=name))) assert reader.named_destinations == {} @pytest.mark.enable_socket def test_outline__issue3462(): url = "https://github.com/user-attachments/files/22293402/e371fffe0b_a7cccde95a.pdf" name = "issue3462.pdf" reader = PdfReader(BytesIO(get_data_from_url(url=url, name=name))) outline_flat = list( itertools.chain.from_iterable( entry if isinstance(entry, list) else [entry] for entry in reader.outline ) ) assert list(map(itemgetter("/Title"), outline_flat)) == [ "AR 2021 - Daftar Isi", "Page 1", "Page 2", "Page 3", "Page 4", "Page 5", "AR 2021 Book 001 (Highlights - Ikhtisar Saham)", "Page 1", "Page 2", "Page 3", "Page 4", "Page 5", "AR 2021 Book 002 (Laporan Manajemen)", "Page 1", "Page 2", "Page 3", "Page 4", "Page 5", "Page 6", "Page 7", "Page 8", "Page 9", "AR 2021 Book 003-1 (Profil Perusahaan)", "Page 1", "Page 2", "Page 3", "Page 4", "Page 5", "Page 6", "Page 7", "Page 8", "Page 9", "Page 10", "Page 11", "Page 12", "Page 13", "Page 14", "Page 15", "Page 16", "Page 17", "Page 18", "Page 19", "Page 20", "Page 21", "Page 22", "Page 23", "Page 24", "Page 25", "Page 26", "Page 27", "Page 28", "Page 29", "Page 30", "Page 31", "Page 32", "Page 33", "Page 34", "Page 35", "Page 36", "Page 37", "Page 38", "Page 39", "Page 40", "Page 41", "Page 42", "Page 43", "Page 44", "Page 45", "Page 46", "Page 47", "AR 2021 Book 003-2 (Sumber Daya Manusia)", "Page 1", "Page 2", "Page 3", "Page 4", "Page 5", "Page 6", "Page 7", "Page 8", "Page 9", "Page 10", "Page 11", "Page 12", "AR 2021 Book 003-3 (Komposisi pemegang saham)", "Page 1", "Page 2", "Page 3", "Page 4", "Page 5", "Page 6", "AR 2021 Book 003-4 (Kronologis Pencatatan Saham)", "Page 1", "Page 2", "AR 2021 Book 003-5 (Akuntan Publik Independen)", "Page 1", "Page 2", "Page 3", "AR 2021 Book 004 (Analisa dan Pembahasan Manajemen)", "Page 1", "Page 2", "Page 3", "Page 4", "Page 5", "Page 6", "Page 7", "Page 8", "Page 9", "Page 10", "Page 11", "Page 12", "Page 13", "Page 14", "Page 15", "Page 16", "Page 17", "Page 18", "Page 19", "Page 20", "Page 21", "AR 2021 Book 005-1 (Tata Kelola Perusahaan)", "Page 1", "Page 2", "Page 3", "Page 4", "Page 5", "Page 6", "Page 7", "Page 8", "Page 9", "Page 10", "Page 11", "Page 12", "AR 2021 Book 005-2 (Direksi-Komisaris)", "Page 1", "Page 2", "Page 3", "Page 4", "Page 5", "Page 6", "Page 7", "Page 8", "Page 9", "Page 10", "Page 11", "Page 12", "Page 13", "Page 14", "Page 15", "Page 16", "Page 17", "Page 18", "Page 19", "Page 20", "Page 21", "Page 22", "Page 23", "Page 24", "Page 25", "Page 26", "Page 27", "Page 28", "Page 29", "Page 30", "Page 31", "Page 32", "Page 33", "Page 34", "Page 35", "Page 36", "Page 37", "Page 38", "AR 2021 Book 005-3 (Komite Audit)", "Page 1", "Page 2", "Page 3", "Page 4", "Page 5", "Page 6", "Page 7", "Page 8", "Page 9", "AR 2021 Book 005-4 (Sekretaris Perusahaan)", "Page 1", "Page 2", "Page 3", "Page 4", "Page 5", "Page 6", "Page 7", "Page 8", "Page 9", "Page 10", "AR 2021 Book 005-5 (Unit Audit Internal)", "Page 1", "Page 2", "Page 3", "Page 4", "Page 5", "Page 6", "AR 2021 Book 005-6 (Sistem Pengendalian Internal)", "Page 1", "Page 2", "Page 3", "Page 4", "Page 5", "Page 6", "Page 7", "Page 8", "AR 2021 Book 005-7 (Program Saham)", "Page 1", "AR 2021 Book 005-8 ( Whistleblowing)", "Page 1", "Page 2", "Page 3", "Page 4", "Page 5", "Page 6", "Page 7", "Page 8", "Page 9", "Page 10", "Page 11", "Page 12", "Page 13", "Page 14", "Page 15", "Page 16", "Page 17", "Page 18", "Page 19", "Page 20", "Page 21", "Page 22", "Page 23", "Page 24", "Page 25", "AR 2021 Book 006 (Tanggung Jawab Sosial - CSR)", "Page 1", "Page 2", "AR 2021 Book 007-1 (LAPORAN KEUANGAN KONSOLIDASIAN)", "Page 1", "AR 2021 Book 007-2 (Isi Laporan Keuangan)", "AR 2021 Book 008 (Tanggung Jawab Atas Laporan Tahunan)", "Page 1", "Page 2" ] pypdf-6.1.2/tests/test_encryption.py000066400000000000000000000302251507516550200176170ustar00rootroot00000000000000"""Test the pypdf._encryption module.""" import secrets from pathlib import Path import pytest import pypdf from pypdf import PasswordType, PdfReader, PdfWriter from pypdf._crypt_providers import crypt_provider from pypdf._crypt_providers._fallback import _DEPENDENCY_ERROR_STR from pypdf._encryption import AlgV5, CryptAES, CryptRC4 from pypdf.errors import DependencyError, PdfReadError USE_CRYPTOGRAPHY = crypt_provider[0] == "cryptography" USE_PYCRYPTODOME = crypt_provider[0] == "pycryptodome" HAS_AES = USE_CRYPTOGRAPHY or USE_PYCRYPTODOME TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" SAMPLE_ROOT = PROJECT_ROOT / "sample-files" @pytest.mark.parametrize( ("name", "requires_aes"), [ # unencrypted pdf ("unencrypted.pdf", False), # created by: # qpdf --encrypt "" "" 40 -- unencrypted.pdf r2-empty-password.pdf ("r2-empty-password.pdf", False), # created by: # qpdf --encrypt "" "" 128 -- unencrypted.pdf r3-empty-password.pdf ("r3-empty-password.pdf", False), # created by: # qpdf --encrypt "asdfzxcv" "" 40 -- unencrypted.pdf r2-user-password.pdf ("r2-user-password.pdf", False), # created by: # qpdf --encrypt "" "asdfzxcv" 40 -- unencrypted.pdf r2-owner-password.pdf ("r2-owner-password.pdf", False), # created by: # qpdf --encrypt "asdfzxcv" "" 128 -- unencrypted.pdf r3-user-password.pdf ("r3-user-password.pdf", False), # created by: # qpdf --encrypt "asdfzxcv" "" 128 --force-V4 -- unencrypted.pdf r4-user-password.pdf ("r4-user-password.pdf", False), # created by: # qpdf --encrypt "" "asdfzxcv" 128 --force-V4 -- unencrypted.pdf r4-owner-password.pdf ("r4-owner-password.pdf", False), # created by: # qpdf --encrypt "asdfzxcv" "" 128 --use-aes=y -- unencrypted.pdf r4-aes-user-password.pdf ("r4-aes-user-password.pdf", True), # created by: # qpdf --encrypt "" "" 256 --force-R5 -- unencrypted.pdf r5-empty-password.pdf ("r5-empty-password.pdf", True), # created by: # qpdf --encrypt "asdfzxcv" "" 256 --force-R5 -- unencrypted.pdf r5-user-password.pdf ("r5-user-password.pdf", True), # created by: # qpdf --encrypt "" "asdfzxcv" 256 --force-R5 -- unencrypted.pdf r5-owner-password.pdf ("r5-owner-password.pdf", True), # created by: # qpdf --encrypt "" "" 256 -- unencrypted.pdf r6-empty-password.pdf ("r6-empty-password.pdf", True), # created by: # qpdf --encrypt "asdfzxcv" "" 256 -- unencrypted.pdf r6-user-password.pdf ("r6-user-password.pdf", True), # created by: # qpdf --encrypt "" "asdfzxcv" 256 -- unencrypted.pdf r6-owner-password.pdf ("r6-owner-password.pdf", True), ], ) def test_encryption(name, requires_aes): """ Encrypted PDFs are handled correctly. This test function ensures that: - If PyCryptodome or cryptography is not available and required, a DependencyError is raised - Encrypted PDFs are identified correctly - Decryption works for encrypted PDFs - Metadata is properly extracted from the decrypted PDF """ inputfile = RESOURCE_ROOT / "encryption" / name if requires_aes and not HAS_AES: with pytest.raises(DependencyError) as exc: ipdf = pypdf.PdfReader(inputfile) ipdf.decrypt("asdfzxcv") dd = dict(ipdf.metadata) assert exc.value.args[0] == _DEPENDENCY_ERROR_STR return ipdf = pypdf.PdfReader(inputfile) if str(inputfile).endswith("unencrypted.pdf"): assert not ipdf.is_encrypted else: assert ipdf.is_encrypted ipdf.decrypt("asdfzxcv") assert len(ipdf.pages) == 1 dd = dict(ipdf.metadata) # remove empty value entry dd = {x[0]: x[1] for x in dd.items() if x[1]} assert dd == { "/Author": "cheng", "/CreationDate": "D:20220414132421+05'24'", "/Creator": "WPS Writer", "/ModDate": "D:20220414132421+05'24'", "/SourceModified": "D:20220414132421+05'24'", "/Trapped": "/False", } @pytest.mark.parametrize( ("name", "user_passwd", "owner_passwd"), [ # created by # qpdf --encrypt "foo" "bar" 256 -- unencrypted.pdf r6-both-passwords.pdf ("r6-both-passwords.pdf", "foo", "bar"), ], ) @pytest.mark.skipif(not HAS_AES, reason="No AES implementation") def test_pdf_with_both_passwords(name, user_passwd, owner_passwd): """ PDFs with both user and owner passwords are handled correctly. This test function ensures that: - Encrypted PDFs with both user and owner passwords are identified correctly - Decryption works for both user and owner passwords - The correct password type is returned after decryption - The number of pages is correctly identified after decryption """ inputfile = RESOURCE_ROOT / "encryption" / name ipdf = pypdf.PdfReader(inputfile) assert ipdf.is_encrypted assert ipdf.decrypt(user_passwd) == PasswordType.USER_PASSWORD assert ipdf.decrypt(owner_passwd) == PasswordType.OWNER_PASSWORD assert len(ipdf.pages) == 1 @pytest.mark.parametrize( ("pdffile", "password"), [ ("crazyones-encrypted-256.pdf", "password"), ("crazyones-encrypted-256.pdf", b"password"), ], ) @pytest.mark.skipif(not HAS_AES, reason="No AES implementation") def test_read_page_from_encrypted_file_aes_256(pdffile, password): """ A page can be read from an encrypted. This is a regression test for issue 327: IndexError for get_page() of decrypted file """ path = RESOURCE_ROOT / pdffile pypdf.PdfReader(path, password=password).pages[0] @pytest.mark.parametrize( "names", [ ( [ "unencrypted.pdf", "r3-user-password.pdf", "r4-aes-user-password.pdf", "r5-user-password.pdf", ] ), ], ) @pytest.mark.skipif(not HAS_AES, reason="No AES implementation") @pytest.mark.filterwarnings("ignore::DeprecationWarning") def test_merge_encrypted_pdfs(names): """Encrypted PDFs can be merged after decryption.""" merger = pypdf.PdfWriter() files = [RESOURCE_ROOT / "encryption" / x for x in names] pdfs = [pypdf.PdfReader(x) for x in files] for pdf in pdfs: if pdf.is_encrypted: pdf.decrypt("asdfzxcv") merger.append(pdf) # no need to write to file merger.close() @pytest.mark.skipif( USE_CRYPTOGRAPHY, reason="Limitations of cryptography. see https://github.com/pyca/cryptography/issues/2494", ) @pytest.mark.parametrize( "cryptcls", [ CryptRC4, ], ) def test_encrypt_decrypt_with_cipher_class(cryptcls): """Encryption and decryption using a cipher class work as expected.""" message = b"Hello World" key = bytes(0 for _ in range(128)) # b"secret key" crypt = cryptcls(key) assert crypt.decrypt(crypt.encrypt(message)) == message def test_attempt_decrypt_unencrypted_pdf(): """Attempting to decrypt an unencrypted PDF raises a PdfReadError.""" path = RESOURCE_ROOT / "crazyones.pdf" with pytest.raises(PdfReadError) as exc: PdfReader(path, password="nonexistent") assert exc.value.args[0] == "Not an encrypted file" @pytest.mark.skipif(not HAS_AES, reason="No AES implementation") def test_alg_v5_generate_values(): """ Algorithm V5 values are generated without raising exceptions. This test function checks if there is an exception during the value generation. It does not verify that the content is correct. """ key = b"0123456789123451" values = AlgV5.generate_values( R=5, user_password=b"foo", owner_password=b"bar", key=key, p=0, metadata_encrypted=True, ) assert values == { "/U": values["/U"], "/UE": values["/UE"], "/O": values["/O"], "/OE": values["/OE"], "/Perms": values["/Perms"], } @pytest.mark.parametrize( ("alg", "requires_aes"), [ ("RC4-40", False), ("RC4-128", False), ("AES-128", True), ("AES-256-R5", True), ("AES-256", True), ("ABCD", False), ], ) def test_pdf_encrypt(pdf_file_path, alg, requires_aes): user_password = secrets.token_urlsafe(10) owner_password = secrets.token_urlsafe(10) reader = PdfReader(RESOURCE_ROOT / "encryption" / "unencrypted.pdf") page = reader.pages[0] text0 = page.extract_text() writer = PdfWriter() writer.add_page(page) # test with invalid algorithm name if alg == "ABCD": with pytest.raises(ValueError) as exc: writer.encrypt( user_password=user_password, owner_password=owner_password, algorithm=alg, ) assert exc.value.args[0] == "Algorithm 'ABCD' NOT supported" return if requires_aes and not HAS_AES: with pytest.raises(DependencyError) as exc: writer.encrypt( user_password=user_password, owner_password=owner_password, algorithm=alg, ) with open(pdf_file_path, "wb") as output_stream: writer.write(output_stream) assert exc.value.args[0] == _DEPENDENCY_ERROR_STR return writer.encrypt( user_password=user_password, owner_password=owner_password, algorithm=alg ) with open(pdf_file_path, "wb") as output_stream: writer.write(output_stream) reader = PdfReader(pdf_file_path) assert reader.is_encrypted assert reader.decrypt(owner_password) == PasswordType.OWNER_PASSWORD assert reader.decrypt(user_password) == PasswordType.USER_PASSWORD page = reader.pages[0] text1 = page.extract_text() assert text0 == text1 @pytest.mark.parametrize( "count", [1, 2, 3, 4, 5, 10], ) def test_pdf_encrypt_multiple(pdf_file_path, count): user_password = secrets.token_urlsafe(10) owner_password = secrets.token_urlsafe(10) reader = PdfReader(RESOURCE_ROOT / "encryption" / "unencrypted.pdf") page = reader.pages[0] text0 = page.extract_text() writer = PdfWriter() writer.add_page(page) if count == 1: owner_password = None for _i in range(count): writer.encrypt( user_password=user_password, owner_password=owner_password, algorithm="RC4-128", ) with open(pdf_file_path, "wb") as output_stream: writer.write(output_stream) reader = PdfReader(pdf_file_path) assert reader.is_encrypted if owner_password is None: # NOTICE: owner_password will set to user_password if it's None assert reader.decrypt(user_password) == PasswordType.OWNER_PASSWORD else: assert reader.decrypt(owner_password) == PasswordType.OWNER_PASSWORD assert reader.decrypt(user_password) == PasswordType.USER_PASSWORD page = reader.pages[0] text1 = page.extract_text() assert text0 == text1 @pytest.mark.skipif(not HAS_AES, reason="No AES implementation") def test_aes_decrypt_corrupted_data(): """Just for robustness""" aes = CryptAES(secrets.token_bytes(16)) for num in [0, 17, 32]: aes.decrypt(secrets.token_bytes(num)) @pytest.mark.samples def test_encrypt_stream_dictionary(pdf_file_path): user_password = secrets.token_urlsafe(10) reader = PdfReader(SAMPLE_ROOT / "023-cmyk-image/cmyk-image.pdf") page = reader.pages[0] original_image_obj = reader.get_object(page.images["/I"].indirect_reference) writer = PdfWriter() writer.add_page(reader.pages[0]) writer.encrypt( user_password=user_password, owner_password=None, algorithm="RC4-128", ) with open(pdf_file_path, "wb") as output_stream: writer.write(output_stream) reader = PdfReader(pdf_file_path) assert reader.is_encrypted assert reader.decrypt(user_password) == PasswordType.OWNER_PASSWORD page = reader.pages[0] decrypted_image_obj = reader.get_object(page.images["/I"].indirect_reference) assert decrypted_image_obj["/ColorSpace"][3] == original_image_obj["/ColorSpace"][3] pypdf-6.1.2/tests/test_filters.py000066400000000000000000000743741507516550200171120ustar00rootroot00000000000000"""Test the pypdf.filters module.""" import os import shutil import string import subprocess import zlib from io import BytesIO from itertools import product as cartesian_product from pathlib import Path from typing import cast from unittest import mock import pytest from PIL import Image, ImageOps from pypdf import PdfReader from pypdf.errors import DependencyError, DeprecationError, LimitReachedError, PdfReadError, PdfStreamError from pypdf.filters import ( ASCII85Decode, ASCIIHexDecode, CCITParameters, CCITTFaxDecode, CCITTParameters, FlateDecode, JBIG2Decode, RunLengthDecode, decompress, ) from pypdf.generic import ( ArrayObject, BooleanObject, ContentStream, DictionaryObject, IndirectObject, NameObject, NullObject, NumberObject, StreamObject, ) from . import PILContext, get_data_from_url from .test_encryption import HAS_AES from .test_images import image_similarity filter_inputs = ( string.ascii_lowercase, string.ascii_uppercase, string.ascii_letters, string.digits, string.hexdigits, string.punctuation, string.whitespace, # Add more... ) TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" @pytest.mark.parametrize( ("predictor", "s"), list(cartesian_product([1], filter_inputs)) ) def test_flate_decode_encode(predictor, s): """FlateDecode encode() and decode() methods work as expected.""" codec = FlateDecode() s = s.encode() encoded = codec.encode(s) assert codec.decode(encoded, DictionaryObject({"/Predictor": predictor})) == s def test_flatedecode_unsupported_predictor(): """ FlateDecode raises PdfReadError for unsupported predictors. Predictors outside the [10, 15] range are not supported. This test function checks that a PdfReadError is raised when decoding with unsupported predictors. Once this predictor support is updated in the future, this test case may be removed. """ codec = FlateDecode() predictors = (-10, -1, 0, 9, 16, 20, 100) for predictor, s in cartesian_product(predictors, filter_inputs): s = s.encode() with pytest.raises(PdfReadError): codec.decode(codec.encode(s), DictionaryObject({"/Predictor": predictor})) @pytest.mark.parametrize( ("data", "expected"), [ (">", b""), ( "6162636465666768696a6b6c6d6e6f707172737475767778797a>", string.ascii_lowercase.encode(), ), ( "4142434445464748494a4b4c4d4e4f505152535455565758595a>", string.ascii_uppercase.encode(), ), ( "6162636465666768696a6b6c6d6e6f707172737475767778797a4142434445464748494a4b4c4d4e4f505152535455565758595a>", string.ascii_letters.encode(), ), ("30313233343536373839>", string.digits.encode()), ( "3 031323334353637 3839>", string.digits.encode(), ), # Same as previous, but whitespaced ("30313233343536373839616263646566414243444546>", string.hexdigits.encode()), ("20090a0d0b0c>", string.whitespace.encode()), # Odd number of hexadecimal digits behaves as if a 0 (zero) followed the last digit ("3938373635343332313>", string.digits[::-1].encode()), ], ids=[ "empty", "ascii_lowercase", "ascii_uppercase", "ascii_letters", "digits", "digits_whitespace", "hexdigits", "whitespace", "odd_number", ], ) def test_ascii_hex_decode_method(data, expected): """ Feeds a bunch of values to ASCIIHexDecode.decode() and ensures the correct output is returned. """ assert ASCIIHexDecode.decode(data) == expected def test_ascii_hex_decode_missing_eod(): """ASCIIHexDecode.decode() raises error when no EOD character is present.""" # with pytest.raises(PdfStreamError) as exc: ASCIIHexDecode.decode("") # assert exc.value.args[0] == "Unexpected EOD in ASCIIHexDecode" @pytest.mark.enable_socket def test_decode_ahx(): """ See #1979 Gray Image in CMYK : requiring reverse """ reader = PdfReader(BytesIO(get_data_from_url(name="NewJersey.pdf"))) for p in reader.pages: _ = list(p.images.keys()) def test_ascii85decode_with_overflow(): inputs = ( v + "~>" for v in "\x01\x02\x03\x04\x05\x06\x07\x08\x0e\x0f" "\x10\x11\x12\x13\x14\x15\x16\x17\x18\x19\x1a" "\x1b\x1c\x1d\x1e\x1fvwxy{|}~\x7f\x80\x81\x82" "\x83\x84\x85\x86\x87\x88\x89\x8a\x8b\x8c\x8d" "\x8e\x8f\x90\x91\x92\x93\x94\x95\x96\x97\x98" "\x99\x9a\x9b\x9c\x9d\x9e\x9f\xa0¡¢£¤¥¦§¨©ª«¬" "\xad®¯°±²³´µ¶·¸¹º»¼½¾¿ÀĂĂ‚ĂÄÅÆÇ" ) for i in inputs: with pytest.raises(ValueError): ASCII85Decode.decode(i) def test_ascii85decode_five_zero_bytes(): """ ASCII85Decode handles the special case of five zero bytes correctly. ISO 32000-1:2008 §7.4.3: «As a special case, if all five bytes are 0, they shall be represented by the character with code 122 (z) instead of by five exclamation points (!!!!!).» """ inputs = ("z", "zz", "zzz") exp_outputs = ( b"\x00\x00\x00\x00", b"\x00\x00\x00\x00" * 2, b"\x00\x00\x00\x00" * 3, ) assert ASCII85Decode.decode("!!!!!~>") == ASCII85Decode.decode("z~>") for expected, i in zip(exp_outputs, inputs): assert ASCII85Decode.decode(i + "~>") == expected def test_ccitparameters(): with pytest.raises( DeprecationError, match=r"CCITParameters is deprecated and was removed in pypdf 6\.0\.0\. Use CCITTParameters instead", ): CCITParameters() def test_ccittparameters(): params = CCITTParameters() assert params.K == 0 # zero is the default according to page 78 assert params.BlackIs1 is False assert params.group == 3 @pytest.mark.parametrize( ("parameters", "expected_k", "expected_black_is_1"), [ (None, 0, False), ( ArrayObject([{"/K": NumberObject(1)}, {"/Columns": NumberObject(13)}, {"/BlackIs1": BooleanObject(True)}]), 1, True ), ], ) def test_ccitt_get_parameters(parameters, expected_k, expected_black_is_1): parameters = CCITTFaxDecode._get_parameters(parameters=parameters, rows=0) assert parameters.K == expected_k # noqa: SIM300 assert parameters.BlackIs1 == expected_black_is_1 def test_ccitt_get_parameters__indirect_object(): class Pdf: def get_object(self, reference) -> NumberObject: return NumberObject(42) parameters = CCITTFaxDecode._get_parameters( parameters=None, rows=IndirectObject(13, 1, Pdf()) ) assert parameters.rows == 42 def test_ccitt_fax_decode(): data = b"" parameters = DictionaryObject( {"/K": NumberObject(-1), "/Columns": NumberObject(17)} ) # This was just the result pypdf 1.27.9 returned. # It would be awesome if we could check if that is actually correct. assert CCITTFaxDecode.decode(data, parameters) == ( b"II*\x00\x08\x00\x00\x00\x08\x00\x00\x01\x04\x00\x01\x00\x00\x00\x11\x00" b"\x00\x00\x01\x01\x04\x00\x01\x00\x00\x00\x00\x00\x00\x00\x02\x01" b"\x03\x00\x01\x00\x00\x00\x01\x00\x00\x00\x03\x01\x03\x00\x01\x00" b"\x00\x00\x04\x00\x00\x00\x06\x01\x03\x00\x01\x00\x00\x00\x00\x00" b"\x00\x00\x11\x01\x04\x00\x01\x00\x00\x00l\x00\x00\x00\x16\x01" b"\x04\x00\x01\x00\x00\x00\x00\x00\x00\x00\x17\x01\x04\x00\x01\x00" b"\x00\x00\x00\x00\x00\x00\x00\x00" ) @pytest.mark.enable_socket def test_decompress_zlib_error(caplog): reader = PdfReader(BytesIO(get_data_from_url(name="tika-952445.pdf"))) for page in reader.pages: page.extract_text() assert "incorrect startxref pointer(3)" in caplog.text @pytest.mark.enable_socket def test_lzw_decode_neg1(): reader = PdfReader(BytesIO(get_data_from_url(name="tika-921632.pdf"))) page = reader.pages[47] assert page.extract_text().startswith("Chapter 2") @pytest.mark.enable_socket def test_issue_399(): reader = PdfReader(BytesIO(get_data_from_url(name="tika-976970.pdf"))) reader.pages[1].extract_text() @pytest.mark.enable_socket def test_image_without_pillow(tmp_path): env = os.environ.copy() env["COVERAGE_PROCESS_START"] = "pyproject.toml" name = "tika-914102.pdf" pdf_path = Path(__file__).parent / "pdf_cache" / name pdf_path_str = pdf_path.resolve().as_posix() source_file = tmp_path / "script.py" source_file.write_text( f""" import sys from pypdf import PdfReader import pytest sys.modules["PIL"] = None reader = PdfReader("{pdf_path_str}", strict=True) for page in reader.pages: with pytest.raises(ImportError) as exc: page.images[0] assert exc.value.args[0] == ( "pillow is required to do image extraction. " "It can be installed via 'pip install pypdf[image]'" ), exc.value.args[0] """ ) try: env["PYTHONPATH"] = "." + os.pathsep + env["PYTHONPATH"] except KeyError: env["PYTHONPATH"] = "." result = subprocess.run( # noqa: S603 # We have the control here. [shutil.which("python"), source_file], capture_output=True, env=env, ) assert result.returncode == 0 assert result.stdout == b"" assert ( result.stderr.replace(b"\r", b"") == b"Superfluous whitespace found in object header b'4' b'0'\n" ) @pytest.mark.enable_socket def test_issue_1737(): reader = PdfReader(BytesIO(get_data_from_url(name="iss1737.pdf"))) reader.pages[0]["/Resources"]["/XObject"]["/Im0"].get_data() reader.pages[0]["/Resources"]["/XObject"]["/Im1"].get_data() reader.pages[0]["/Resources"]["/XObject"]["/Im2"].get_data() @pytest.mark.enable_socket def test_pa_image_extraction(): """ PNG images with PA mode can be extracted. This is a regression test for issue #1801 """ reader = PdfReader(BytesIO(get_data_from_url(name="issue-1801.pdf"))) page0 = reader.pages[0] images = page0.images assert len(images) == 1 assert images[0].name == "Im1.png" # Ensure visual appearance expected_data = BytesIO(get_data_from_url(name="issue-1801.png")) assert image_similarity(expected_data, images[0].image) == 1 @pytest.mark.enable_socket def test_1bit_image_extraction(): """Cf issue #1814""" reader = PdfReader(BytesIO(get_data_from_url(name="grimm10"))) for p in reader.pages: p.images @pytest.mark.enable_socket def test_png_transparency_reverse(): """Cf issue #1599""" pdf_path = RESOURCE_ROOT / "labeled-edges-center-image.pdf" reader = PdfReader(pdf_path) refimg = Image.open( BytesIO(get_data_from_url(name="labeled-edges-center-image.png")) ) data = reader.pages[0].images[0] img = Image.open(BytesIO(data.data)) assert ".jp2" in data.name assert list(img.getdata()) == list(refimg.getdata()) @pytest.mark.enable_socket def test_iss1787(): """Cf issue #1787""" reader = PdfReader(BytesIO(get_data_from_url(name="pdf_font_garbled.pdf"))) refimg = Image.open(BytesIO(get_data_from_url(name="watermark1.png"))) data = reader.pages[0].images[0] img = Image.open(BytesIO(data.data)) assert ".png" in data.name assert list(img.getdata()) == list(refimg.getdata()) obj = data.indirect_reference.get_object() obj["/DecodeParms"][NameObject("/Columns")] = NumberObject(1000) obj.decoded_self = None with pytest.raises(expected_exception=PdfReadError, match=r"^Unsupported PNG filter 244$"): _ = reader.pages[0].images[0] @pytest.mark.enable_socket def test_tiff_predictor(): """Decode Tiff Predictor 2 Images""" reader = PdfReader(BytesIO(get_data_from_url(name="tika-977609.pdf"))) refimg = Image.open(BytesIO(get_data_from_url(name="tifimage.png"))) data = reader.pages[0].images[0] img = Image.open(BytesIO(data.data)) assert ".png" in data.name assert list(img.getdata()) == list(refimg.getdata()) @pytest.mark.enable_socket def test_rgba(): """Decode RGB with transparency""" with PILContext(): reader = PdfReader(BytesIO(get_data_from_url(name="tika-972174.pdf"))) data = reader.pages[0].images[0] assert ".jp2" in data.name similarity = image_similarity( data.image, BytesIO(get_data_from_url(name="tika-972174_p0-im0.png")) ) assert similarity > 0.99 @pytest.mark.enable_socket def test_cmyk(): """Decode CMYK""" # JPEG compression try: from Crypto.Cipher import AES # noqa: F401, PLC0415 except ImportError: return # the file is encrypted reader = PdfReader(BytesIO(get_data_from_url(name="Vitocal.pdf"))) refimg = BytesIO(get_data_from_url(name="VitocalImage.png")) data = reader.pages[1].images[0] assert data.image.mode == "CMYK" assert ".jpg" in data.name assert image_similarity(data.image, refimg) > 0.99 # deflate reader = PdfReader(BytesIO(get_data_from_url(name="cmyk_deflate.pdf"))) refimg = BytesIO(get_data_from_url(name="cmyk_deflate.tif")) data = reader.pages[0].images[0] assert data.image.mode == "CMYK" assert ".tif" in data.name assert image_similarity(data.image, refimg) > 0.999 # lossless compression expected @pytest.mark.enable_socket def test_iss1863(): """Test doc from iss1863""" reader = PdfReader(BytesIO(get_data_from_url(name="o1whh9b3.pdf"))) for p in reader.pages: for i in p.images: i.name @pytest.mark.enable_socket def test_read_images(): reader = PdfReader(BytesIO(get_data_from_url(name="selbst.72916.pdf"))) page = reader.pages[0] for _ in page.images: pass @pytest.mark.enable_socket def test_cascaded_filters_images(): reader = PdfReader(BytesIO(get_data_from_url(name="iss1912.pdf"))) # for focus, analyse the page 23 for p in reader.pages: for i in p.images: _ = i.name, i.image @pytest.mark.enable_socket def test_calrgb(): reader = PdfReader(BytesIO(get_data_from_url(name="calRGB.pdf"))) reader.pages[0].images[0] @pytest.mark.enable_socket def test_index_lookup(): """The lookup is provided as an str and bytes""" reader = PdfReader(BytesIO(get_data_from_url(name="2023USDC.pdf"))) # TextStringObject Lookup refimg = BytesIO(get_data_from_url(name="iss1982_im1.png")) data = reader.pages[0].images[-1] assert data.image.mode == "RGB" assert image_similarity(data.image, refimg) > 0.999 # ByteStringObject Lookup refimg = BytesIO(get_data_from_url(name="iss1982_im2.png")) data = reader.pages[-1].images[-1] assert data.image.mode == "RGB" assert image_similarity(data.image, refimg) > 0.999 # indexed CMYK images # currently with a TODO as we convert the palette to RGB reader = PdfReader(BytesIO(get_data_from_url(name="tika-972174.pdf"))) refimg = Image.open(BytesIO(get_data_from_url(name="usa.png"))) data = reader.pages[0].images["/Im3"] # assert data.image.mode == "PA" but currently "RGBA" assert image_similarity(data.image, refimg) > 0.999 @pytest.mark.enable_socket def test_2bits_image(): """From #1954, test with 2bits image. TODO: 4bits also""" reader = PdfReader(BytesIO(get_data_from_url(name="paid.pdf"))) url_png = "https://user-images.githubusercontent.com/4083478/253568117-ca95cc85-9dea-4145-a5e0-032f1c1aa322.png" name_png = "Paid.png" refimg = BytesIO(get_data_from_url(url_png, name=name_png)) data = reader.pages[0].images[0] assert image_similarity(data.image, refimg) > 0.99 @pytest.mark.enable_socket def test_gray_devicen_cmyk(): """ Cf #1979 Gray Image in CMYK : requiring reverse """ url = "https://github.com/py-pdf/pypdf/files/12080338/example_121.pdf" name = "gray_cmyk.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) url_png = "https://user-images.githubusercontent.com/4083478/254545494-42df4949-1557-4f2d-acca-6be6e8de1122.png" name_png = "velo.png" refimg = BytesIO(get_data_from_url(url_png, name=name_png)) data = reader.pages[0].images[0] assert data.image.mode == "L" assert image_similarity(data.image, refimg) > 0.999 @pytest.mark.enable_socket def test_runlengthdecode(): """From #1954, test with 2bits image. TODO: 4bits also""" url = "https://github.com/py-pdf/pypdf/files/12159941/out.pdf" name = "RunLengthDecode.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) url_png = "https://user-images.githubusercontent.com/4083478/255940800-6d63972e-a3d6-4cf9-aa6f-0793af24cded.png" name_png = "RunLengthDecode.png" refimg = BytesIO(get_data_from_url(url_png, name=name_png)) data = reader.pages[0].images[0] assert image_similarity(data.image, refimg) > 0.999 url = "https://github.com/py-pdf/pypdf/files/12162905/out.pdf" name = "FailedRLE1.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.pages[0].images[0] url = "https://github.com/py-pdf/pypdf/files/12162926/out.pdf" name = "FailedRLE2.pdf" reader.pages[0].images[0] @pytest.mark.enable_socket def test_gray_separation_cmyk(): """ Cf #1955 Gray Image in Separation/RGB : requiring reverse """ url = "https://github.com/py-pdf/pypdf/files/12143372/tt.pdf" name = "TestWithSeparationBlack.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) url_png = "https://user-images.githubusercontent.com/4083478/254545494-42df4949-1557-4f2d-acca-6be6e8de1122.png" name_png = "velo.png" # reused refimg = BytesIO(get_data_from_url(url_png, name=name_png)) data = reader.pages[0].images[0] assert data.image.mode == "L" assert image_similarity(data.image, refimg) > 0.999 @pytest.mark.enable_socket def test_singleton_device(): """From #2023""" url = "https://github.com/py-pdf/pypdf/files/12177287/tt.pdf" name = "pypdf_with_arr_deviceRGB.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.pages[0].images[0] @pytest.mark.enable_socket def test_jpx_no_spacecode(): """From #2061""" url = "https://github.com/py-pdf/pypdf/files/12253581/tt2.pdf" name = "jpx_no_spacecode.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) im = reader.pages[0].images[0] # create an object without filter and without colorspace # just for coverage del im.indirect_reference.get_object()["/Filter"] with pytest.raises(PdfReadError) as exc: reader.pages[0].images[0] assert exc.value.args[0].startswith("ColorSpace field not found") @pytest.mark.enable_socket def test_encodedstream_lookup(): """From #2124""" url = "https://github.com/py-pdf/pypdf/files/12455580/10.pdf" name = "iss2124.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.pages[12].images[0] @pytest.mark.enable_socket def test_convert_1_to_la(): """From #2165""" url = "https://github.com/py-pdf/pypdf/files/12543290/whitepaper.WBT.token.blockchain.whitepaper.pdf" name = "iss2165.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) for i in reader.pages[13].images: _ = i @pytest.mark.enable_socket def test_nested_device_n_color_space(): """From #2240""" url = "https://github.com/py-pdf/pypdf/files/12814018/out1.pdf" name = "issue2240.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.pages[0].images[0] @pytest.mark.enable_socket @pytest.mark.skipif(not HAS_AES, reason="No AES implementation") def test_flate_decode_with_image_mode_1(): """From #2248""" url = "https://github.com/py-pdf/pypdf/files/12847339/Prototype-Declaration-VDE4110-HYD-5000-20000-ZSS-DE.pdf" name = "issue2248.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) for image in reader.pages[7].images: _ = image @pytest.mark.enable_socket def test_flate_decode_with_image_mode_1__whitespace_at_end_of_lookup(): """From #2331""" url = "https://github.com/py-pdf/pypdf/files/13611048/out1.pdf" name = "issue2331.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.pages[0].images[0] @pytest.mark.enable_socket def test_ascii85decode__invalid_end__recoverable(caplog): """From #2996""" url = "https://github.com/user-attachments/files/18050808/1af7d56a-5c8c-4914-85b3-b2536a5525cd.pdf" name = "issue2996.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) page = reader.pages[1] assert page.extract_text() == "" assert "Ignoring missing Ascii85 end marker." in caplog.text def test_ascii85decode__non_recoverable(caplog): # Without our custom handling, this would complain about the final `~>` being missing. data = "äöüß" with pytest.raises(ValueError, match="Non-Ascii85 digit found: Ă"): ASCII85Decode.decode(data) assert "Ignoring missing Ascii85 end marker." in caplog.text caplog.clear() data += "~>" with pytest.raises(ValueError, match="Non-Ascii85 digit found: Ă"): ASCII85Decode.decode(data) assert caplog.text == "" @pytest.mark.enable_socket def test_ccitt_fax_decode__black_is_1(): url = "https://github.com/user-attachments/files/19288881/imagemagick-CCITTFaxDecode_BlackIs1-true.pdf" name = "issue3193.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) other_reader = PdfReader(RESOURCE_ROOT / "imagemagick-CCITTFaxDecode.pdf") actual_image = reader.pages[0].images[0].image expected_image_inverted = other_reader.pages[0].images[0].image expected_pixels = list(ImageOps.invert(expected_image_inverted).getdata()) actual_pixels = list(actual_image.getdata()) assert expected_pixels == actual_pixels # AttributeError: 'NullObject' object has no attribute 'get' data_modified = get_data_from_url(url, name=name).replace( b"/DecodeParms [ << /K -1 /BlackIs1 true /Columns 16 /Rows 16 >> ]", b"/DecodeParms [ null ]" ) reader = PdfReader(BytesIO(data_modified)) _ = reader.pages[0].images[0].image @pytest.mark.enable_socket def test_flate_decode__image_is_none_due_to_size_limit(caplog): url = "https://github.com/user-attachments/files/19464256/file.pdf" name = "issue3220.pdf" with mock.patch("pypdf.filters.ZLIB_MAX_OUTPUT_LENGTH", 0): reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) images = reader.pages[0].images assert len(images) == 1 image = images[0] assert image.name == "Im0.png" assert image.image is None assert ( "Failed loading image: Image size (180000000 pixels) exceeds limit of " "178956970 pixels, could be decompression bomb DOS attack." ) in caplog.messages @pytest.mark.enable_socket def test_flate_decode__not_rectangular(caplog): url = "https://github.com/user-attachments/files/19663603/issue3241_compressed.txt" name = "issue3241.txt" data = get_data_from_url(url, name=name) decode_parms = DictionaryObject() decode_parms[NameObject("/Predictor")] = NumberObject(15) decode_parms[NameObject("/Columns")] = NumberObject(4881) actual = FlateDecode.decode(data=data, decode_parms=decode_parms) actual_image = Image.frombytes(mode="1", size=(4881, 81), data=actual) url = "https://github.com/user-attachments/assets/c5695850-c076-4255-ab72-7c86851a4a04" name = "issue3241.png" expected_data = BytesIO(get_data_from_url(url, name=name)) assert image_similarity(expected_data, actual_image) == 1 assert caplog.messages == ["Image data is not rectangular. Adding padding."] def test_jbig2decode__binary_errors(): with mock.patch("pypdf.filters.JBIG2DEC_BINARY", None), \ pytest.raises(DependencyError, match=r"jbig2dec binary is not available\."): JBIG2Decode.decode(b"dummy") result = subprocess.CompletedProcess( args=["dummy"], returncode=0, stdout=b"", stderr=( b"jbig2dec: unrecognized option '--embedded'\n" b"Usage: jbig2dec [options] \n" b" or jbig2dec [options] \n" ) ) with mock.patch("pypdf.filters.subprocess.run", return_value=result), \ mock.patch("pypdf.filters.JBIG2DEC_BINARY", "/usr/bin/jbig2dec"), \ pytest.raises(DependencyError, match=r"jbig2dec>=0.15 is required\."): JBIG2Decode.decode(b"dummy") @pytest.mark.skipif(condition=not JBIG2Decode._is_binary_compatible(), reason="Requires recent jbig2dec") def test_jbig2decode__edge_cases(caplog): image_data = ( b'\x00\x00\x00\x010\x00\x01\x00\x00\x00\x13\x00\x00\x00\x05\x00\x00\x00\x05\x00\x00\x00\x00\x00\x00\x00\x00\x00\x00\x00\x00\x00\x00\x02\x06"' b'\x00\x01\x00\x00\x00\x1c\x00\x00\x00\x05\x00\x00\x00\x05\x00\x00\x00\x00\x00\x00\x00\x00\x00\x00\x00\x00\x00\x00\x01\x9f\xa8_\xff\xac' ) jbig2_globals = b"\x00\x00\x00\x00\x00\x01\x00\x00\x00\x00\x18\x00\x00\x03\xff\xfd\xff\x02\xfe\xfe\xfe\x00\x00\x00\x01\x00\x00\x00\x01R\xd0u7\xff\xac" # noqa: E501 # Validation: Is our image data valid? content_stream = ContentStream(stream=None, pdf=None) content_stream.set_data(jbig2_globals) result = JBIG2Decode.decode(image_data, decode_parms=DictionaryObject({"/JBIG2Globals": content_stream})) image = Image.open(BytesIO(result), formats=("PNG",)) for x in range(5): for y in range(5): assert image.getpixel((x, y)) == (255 if x < 3 else 0), (x, y) assert caplog.messages == [] # No decode_params. Completely white image. result = JBIG2Decode.decode(image_data) image = Image.open(BytesIO(result), formats=("PNG",)) for x in range(5): for y in range(5): assert image.getpixel((x, y)) == 255, (x, y) assert caplog.messages == [ "jbig2dec WARNING text region refers to no symbol dictionaries (segment 0x00000002)", "jbig2dec WARNING ignoring out of range symbol ID (0/0) (segment 0x00000002)" ] caplog.clear() # JBIG2Globals is NULL. Completely white image. result = JBIG2Decode.decode(image_data, decode_parms=DictionaryObject({"/JBIG2Globals": NullObject()})) image = Image.open(BytesIO(result), formats=("PNG",)) for x in range(5): for y in range(5): assert image.getpixel((x, y)) == 255, (x, y) assert caplog.messages == [ "jbig2dec WARNING text region refers to no symbol dictionaries (segment 0x00000002)", "jbig2dec WARNING ignoring out of range symbol ID (0/0) (segment 0x00000002)" ] caplog.clear() # JBIG2Globals is DictionaryObject. Completely white image. result = JBIG2Decode.decode(image_data, decode_parms=DictionaryObject({"/JBIG2Globals": DictionaryObject()})) image = Image.open(BytesIO(result), formats=("PNG",)) for x in range(5): for y in range(5): assert image.getpixel((x, y)) == 255, (x, y) assert caplog.messages == [ "jbig2dec WARNING text region refers to no symbol dictionaries (segment 0x00000002)", "jbig2dec WARNING ignoring out of range symbol ID (0/0) (segment 0x00000002)" ] caplog.clear() # Invalid input. with pytest.raises(PdfStreamError, match=r"Unable to decode JBIG2 data\. Exit code: 1"): JBIG2Decode.decode(b"aaaaaa") assert caplog.messages == [ "jbig2dec FATAL ERROR page has no image, cannot be completed", "jbig2dec WARNING unable to complete page" ] @pytest.mark.timeout(timeout=30, method="thread") @pytest.mark.enable_socket def test_flate_decode_stream_with_faulty_tail_bytes(): """ Test for #3332 The test ensures two things: 1. stream can be decoded at all 2. decoding doesn't falls through to last fallback in try-except blocks that is too slow and takes ages for this stream """ data = get_data_from_url( url="https://github.com/user-attachments/files/20901522/faulty_stream_tail_example.1.pdf", name="faulty_stream_tail_example.1.pdf" ) expected = get_data_from_url( url="https://github.com/user-attachments/files/20941717/decoded.dat.txt", name="faulty_stream_tail_example.1.decoded.dat" ) reader = PdfReader(BytesIO(data)) obj = reader.get_object(IndirectObject(182, 0, reader)) assert cast(StreamObject, obj).get_data() == expected @pytest.mark.enable_socket def test_rle_decode_with_faulty_tail_byte_in_multi_encoded_stream(caplog): """ Test for #3355 The test ensures that the inner RLE encoded stream can be decoded, because this stream contains an extra faulty newline byte in the end that can be ignored during decoding. """ data = get_data_from_url( url="https://github.com/user-attachments/files/21038398/test_data_rle.txt", name="multi_decoding_example_with_faulty_tail_byte.pdf" ) reader = PdfReader(BytesIO(data)) obj = reader.get_object(IndirectObject(60, 0, reader)) cast(StreamObject, obj).get_data() assert "Found trailing newline in stream data, check if output is OK" in caplog.messages @pytest.mark.enable_socket def test_rle_decode_exception_with_corrupted_stream(): """ Additional Test to #3355 This test must raise the EOD exception during RLE decoding and ensures that we do not fail during code coverage analyses in the git PR pipeline. """ data = get_data_from_url( url="https://github.com/user-attachments/files/21052626/rle_stream_with_error.txt", name="rle_stream_with_error.txt" ) with pytest.raises(PdfStreamError, match="Early EOD in RunLengthDecode"): RunLengthDecode.decode(data) def test_decompress(): data = string.printable.encode("utf-8") + string.printable[::-1].encode("utf-8") compressed = FlateDecode.encode(data) # # Decompress regularly. decompressed = decompress(compressed) assert decompressed == data # # Decompress byte-wise. with mock.patch("pypdf.filters._decompress_with_limit", side_effect=zlib.error): decompressed = decompress(compressed) assert decompressed == data # Decompress byte-wise with very low output limit. with mock.patch("pypdf.filters._decompress_with_limit", side_effect=zlib.error), \ mock.patch("pypdf.filters.ZLIB_MAX_OUTPUT_LENGTH", len(compressed) - 13), \ pytest.raises( LimitReachedError, match=r"^Limit reached while decompressing\. 12 bytes remaining\." ): decompress(compressed) pypdf-6.1.2/tests/test_font.py000066400000000000000000000021021507516550200163640ustar00rootroot00000000000000"""Test font-related functionality.""" from pypdf._font import FontDescriptor from pypdf.generic import DictionaryObject, NameObject def test_font_descriptor(): font_res = DictionaryObject({NameObject("/BaseFont"): NameObject("/Helvetica")}) my_font = FontDescriptor.from_font_resource(font_res) assert my_font.family == "Helvetica" assert my_font.weight == "Medium" assert my_font.ascent == 718 assert my_font.descent == -207 test_string = "This is a long sentence. !@%%^€€€. çûįö¶´" charwidth = sum(my_font.character_widths[char] for char in test_string) assert charwidth == 19251 font_res = DictionaryObject({NameObject("/BaseFont"): NameObject("/Palatino")}) my_font = FontDescriptor.from_font_resource(font_res) assert my_font.weight == "Unknown" font_res = DictionaryObject({NameObject("/BaseFont"): NameObject("/Courier-Bold")}) my_font = FontDescriptor.from_font_resource(font_res) assert my_font.italic_angle == 0 assert my_font.flags == 33 assert my_font.bbox == (-113.0, -250.0, 749.0, 801.0) pypdf-6.1.2/tests/test_forms.py000066400000000000000000000013361507516550200165540ustar00rootroot00000000000000"""Test form-related functionality. Separate file to keep overview.""" from io import BytesIO import pytest from pypdf import PdfReader, PdfWriter from tests import get_data_from_url @pytest.mark.enable_socket def test_form_button__v_value_should_be_name_object(): url = "https://github.com/user-attachments/files/18736500/blank-form.pdf" name = "issue3115.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter(clone_from=reader) writer.update_page_form_field_values( writer.pages[0], {"Other": "/On"}, auto_regenerate=False, ) stream = BytesIO() writer.write(stream) # Wrong: `/V (/On)`. assert b"\n/V /On\n" in stream.getvalue() pypdf-6.1.2/tests/test_generic.py000066400000000000000000001200751507516550200170440ustar00rootroot00000000000000"""Test the pypdf.generic module.""" import codecs from base64 import a85encode from copy import deepcopy from io import BytesIO from pathlib import Path import pytest from pypdf import PdfReader, PdfWriter from pypdf.constants import CheckboxRadioButtonAttributes from pypdf.errors import DeprecationError, PdfReadError, PdfStreamError from pypdf.generic import ( ArrayObject, BooleanObject, ByteStringObject, ContentStream, DecodedStreamObject, Destination, DictionaryObject, Fit, FloatObject, IndirectObject, NameObject, NullObject, NumberObject, OutlineItem, PdfObject, RectangleObject, StreamObject, TextStringObject, TreeObject, create_string_object, encode_pdfdocencoding, is_null_or_none, read_hex_string_from_stream, read_object, read_string_from_stream, ) from pypdf.generic._image_inline import ( extract_inline_A85, extract_inline_AHx, extract_inline_DCT, extract_inline_RL, ) from . import ReaderDummy, get_data_from_url TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" class ChildDummy(DictionaryObject): @property def indirect_reference(self): return self def test_float_object_exception(caplog): assert FloatObject("abc") == 0 assert caplog.text != "" def test_number_object_exception(caplog): assert NumberObject("0,0") == 0 assert caplog.text != "" def test_number_object_no_exception(): NumberObject(2**100_000_000) def test_create_string_object_exception(): with pytest.raises(TypeError) as exc: create_string_object(123) assert ( # typeguard is not running exc.value.args[0] == "create_string_object should have str or unicode arg" ) or ( # typeguard is enabled 'type of argument "string" must be one of (str, bytes); got int instead' in exc.value.args[0] ) @pytest.mark.parametrize( ("value", "expected", "tell"), [(b"true", b"true", 4), (b"false", b"false", 5)] ) def test_boolean_object(value, expected, tell): stream = BytesIO(value) assert BooleanObject.read_from_stream(stream).value == (expected == b"true") stream.seek(0, 0) assert stream.read() == expected assert stream.tell() == tell def test_boolean_object_write(): stream = BytesIO() boolobj = BooleanObject(None) boolobj.write_to_stream(stream) stream.seek(0, 0) assert stream.read() == b"false" def test_boolean_eq(): boolobj = BooleanObject(True) assert (boolobj == True) is True # noqa: E712 assert (boolobj == False) is False # noqa: E712 assert (boolobj == "True") is False hash1 = hash(boolobj) assert hash1 == hash(boolobj) boolobj = BooleanObject(False) assert (boolobj == True) is False # noqa: E712 assert (boolobj == False) is True # noqa: E712 assert (boolobj == "True") is False assert hash1 != hash(boolobj) def test_boolean_object_exception(): stream = BytesIO(b"False") with pytest.raises(PdfReadError) as exc: BooleanObject.read_from_stream(stream) assert exc.value.args[0] == "Could not read Boolean object" def test_array_object_exception(): stream = BytesIO(b"False") with pytest.raises(PdfReadError) as exc: ArrayObject.read_from_stream(stream, None) assert exc.value.args[0] == "Could not read array" def test_null_object_exception(): stream = BytesIO(b"notnull") with pytest.raises(PdfReadError) as exc: NullObject.read_from_stream(stream) assert exc.value.args[0] == "Could not read Null object" @pytest.mark.parametrize("value", [b"", b"False", b"foo ", b"foo ", b"foo bar"]) def test_indirect_object_premature(value): stream = BytesIO(value) with pytest.raises(PdfStreamError) as exc: IndirectObject.read_from_stream(stream, None) assert exc.value.args[0] == "Stream has ended unexpectedly" def test_read_hex_string_from_stream(): stream = BytesIO(b"a1>") assert read_hex_string_from_stream(stream) == "\x10" def test_read_hex_string_from_stream_exception(): stream = BytesIO(b"") with pytest.raises(PdfStreamError) as exc: read_hex_string_from_stream(stream) assert exc.value.args[0] == "Stream has ended unexpectedly" def test_read_string_from_stream_exception(): stream = BytesIO(b"x") with pytest.raises(PdfStreamError) as exc: read_string_from_stream(stream) assert exc.value.args[0] == "Stream has ended unexpectedly" def test_read_string_from_stream_not_in_escapedict_no_digit(): stream = BytesIO(b"x\\y") with pytest.raises(PdfReadError) as exc: read_string_from_stream(stream) assert exc.value.args[0] == "Stream has ended unexpectedly" def test_read_string_from_stream_multichar_eol(): stream = BytesIO(b"x\\\n )") assert read_string_from_stream(stream) == " " def test_read_string_from_stream_multichar_eol2(): stream = BytesIO(b"x\\\n\n)") assert read_string_from_stream(stream) == "" def test_read_string_from_stream_excape_digit(): stream = BytesIO(b"x\\1a )") assert read_string_from_stream(stream) == "\x01a " def test_read_string_from_stream_excape_digit2(): stream = BytesIO(b"(hello \\1\\2\\3\\4)") assert read_string_from_stream(stream) == "hello \x01\x02\x03\x04" def test_name_object(caplog): stream = BytesIO(b"x") with pytest.raises(PdfReadError) as exc: NameObject.read_from_stream(stream, None) assert exc.value.args[0] == "Name read error" with pytest.raises( DeprecationError, match=r"surfix is deprecated and was removed in pypdf 5\.0\.0\. Use prefix instead\.", ): _ = NameObject.surfix assert ( NameObject.read_from_stream( BytesIO(b"/A;Name_With-Various***Characters?"), None ) == "/A;Name_With-Various***Characters?" ) assert ( NameObject.read_from_stream(BytesIO(b"/paired#28#29parentheses"), None) == "/paired()parentheses" ) assert NameObject.read_from_stream(BytesIO(b"/A#42"), None) == "/AB" assert ( NameObject.read_from_stream( BytesIO(b"/#f1j#d4#aa#0c#ce#87#b4#b3#b0#23J#86#fe#2a#b2jYJ#94"), ReaderDummy(), ) == "/ñjÔª\x0cĂŽ\x87´³°#J\x86Ăľ*²jYJ\x94" ) assert (NameObject.read_from_stream(BytesIO(b"/#JA#231f"), None)) == "/#JA#1f" assert ( NameObject.read_from_stream( BytesIO(b"/#e4#bd#a0#e5#a5#bd#e4#b8#96#e7#95#8c"), None ) ) == "/你好世界" # test PDFDocEncoding (latin-1) assert ( NameObject.read_from_stream(BytesIO(b"/DocuSign\xae"), None) ) == "/DocuSign®" # test write b = BytesIO() NameObject("/hello").write_to_stream(b) assert bytes(b.getbuffer()) == b"/hello" caplog.clear() b = BytesIO() with pytest.raises( expected_exception=DeprecationError, match=r"Incorrect first char in NameObject, should start with '/': \(hello\) is deprecated and was" ): NameObject("hello").write_to_stream(b) caplog.clear() b = BytesIO() NameObject("/DIJMAC+Arial Black#1").write_to_stream(b) assert bytes(b.getbuffer()) == b"/DIJMAC+Arial#20Black#231" assert caplog.text == "" caplog.clear() b = BytesIO() NameObject("/你好世界 (%)").write_to_stream(b) assert bytes(b.getbuffer()) == b"/#E4#BD#A0#E5#A5#BD#E4#B8#96#E7#95#8C#20#28#25#29" assert caplog.text == "" caplog.clear() b = BytesIO() NameObject("/{foo}(baz)[qux]#/%").write_to_stream(b) assert bytes(b.getbuffer()) == b"/#7Bfoo#7D#3Cbar#3E#28baz#29#5Bqux#5D#23#2F#25" assert caplog.text == "" def test_destination_fit_r(): d = Destination( TextStringObject("title"), NullObject(), Fit.fit_rectangle(0, 0, 0, 0) ) assert d.title == NameObject("title") assert d.typ == "/FitR" assert d.zoom is None assert d.left == FloatObject(0) assert d.right == FloatObject(0) assert d.top == FloatObject(0) assert d.bottom == FloatObject(0) assert list(d) == [] d.empty_tree() def test_destination_fit_v(): d = Destination(NameObject("title"), NullObject(), Fit.fit_vertically(left=0)) writer = PdfWriter() writer.add_named_destination_object(d) # Trigger Exception Destination(NameObject("title"), NullObject(), Fit.fit_vertically(left=None)) def test_outline_item_write_to_stream(): stream = BytesIO() oi = OutlineItem(NameObject("title"), NullObject(), Fit.fit_vertically(left=0)) oi.write_to_stream(stream) stream.seek(0, 0) assert stream.read() == b"<<\n/Title (title)\n/Dest [ null /FitV 0.0 ]\n>>" def test_encode_pdfdocencoding_keyerror(): with pytest.raises(UnicodeEncodeError) as exc: encode_pdfdocencoding("đź€") assert exc.value.args[0] == "pdfdocencoding" @pytest.mark.parametrize("test_input", ["", "data"]) def test_encode_pdfdocencoding_returns_bytes(test_input): """ Test that encode_pdfdocencoding() always returns bytes because bytearray is duck type compatible with bytes in mypy """ out = encode_pdfdocencoding(test_input) assert isinstance(out, bytes) def test_read_object_comment_exception(): stream = BytesIO(b"% foobar") pdf = None with pytest.raises(PdfStreamError) as exc: read_object(stream, pdf) assert exc.value.args[0] == "File ended unexpectedly." def test_read_object_empty(): stream = BytesIO(b"endobj") pdf = None assert isinstance(read_object(stream, pdf), NullObject) def test_read_object_empty_in_array(): stream = BytesIO(b"[endobj") pdf = None result = read_object(stream, pdf) assert isinstance(result, ArrayObject) assert len(result) == 1 assert isinstance(result[0], NullObject) def test_read_object_invalid(): stream = BytesIO(b"hello") pdf = None with pytest.raises(PdfReadError) as exc: read_object(stream, pdf) assert "hello" in exc.value.args[0] def test_read_object_comment(): stream = BytesIO(b"% foobar\n1 ") pdf = None out = read_object(stream, pdf) assert out == 1 def test_bytestringobject(): bo = ByteStringObject("stream", encoding="utf-8") stream = BytesIO(b"") bo.write_to_stream(stream) stream.seek(0, 0) assert stream.read() == b"<73747265616d>" # TODO: how can we verify this? def test_dictionaryobject_key_is_no_pdfobject(): do = DictionaryObject({NameObject("/S"): NameObject("/GoTo")}) with pytest.raises(ValueError) as exc: do["foo"] = NameObject("/GoTo") assert exc.value.args[0] == "Key must be a PdfObject" def test_dictionaryobject_xmp_meta(): do = DictionaryObject({NameObject("/S"): NameObject("/GoTo")}) assert do.xmp_metadata is None def test_dictionaryobject_value_is_no_pdfobject(): do = DictionaryObject({NameObject("/S"): NameObject("/GoTo")}) with pytest.raises(ValueError) as exc: do[NameObject("/S")] = "/GoTo" assert exc.value.args[0] == "Value must be a PdfObject" def test_dictionaryobject_setdefault_key_is_no_pdfobject(): do = DictionaryObject({NameObject("/S"): NameObject("/GoTo")}) with pytest.raises(ValueError) as exc: do.setdefault("foo", NameObject("/GoTo")) assert exc.value.args[0] == "Key must be a PdfObject" def test_dictionaryobject_setdefault_value_is_no_pdfobject(): do = DictionaryObject({NameObject("/S"): NameObject("/GoTo")}) with pytest.raises(ValueError) as exc: do.setdefault(NameObject("/S"), "/GoTo") assert exc.value.args[0] == "Value must be a PdfObject" def test_dictionaryobject_setdefault_value(): do = DictionaryObject({NameObject("/S"): NameObject("/GoTo")}) do.setdefault(NameObject("/S"), NameObject("/GoTo")) def test_dictionaryobject_read_from_stream(): stream = BytesIO(b"<< /S /GoTo >>") pdf = None out = DictionaryObject.read_from_stream(stream, pdf) assert out.get_object() == {NameObject("/S"): NameObject("/GoTo")} def test_dictionaryobject_read_from_stream_broken(): stream = BytesIO(b"< /S /GoTo >>") pdf = None with pytest.raises(PdfReadError) as exc: DictionaryObject.read_from_stream(stream, pdf) assert ( exc.value.args[0] == "Dictionary read error at byte 0x2: stream must begin with '<<'" ) def test_dictionaryobject_read_from_stream_unexpected_end(): stream = BytesIO(b"<< \x00/S /GoTo") pdf = None with pytest.raises(PdfStreamError) as exc: DictionaryObject.read_from_stream(stream, pdf) assert exc.value.args[0] == "Stream has ended unexpectedly" def test_dictionaryobject_read_from_stream_stream_no_newline(): stream = BytesIO(b"<< /S /GoTo >>stream") pdf = None with pytest.raises(PdfReadError) as exc: DictionaryObject.read_from_stream(stream, pdf) assert exc.value.args[0] == "Stream data must be followed by a newline" @pytest.mark.parametrize(("strict"), [(True), (False)]) def test_dictionaryobject_read_from_stream_stream_no_stream_length(strict, caplog): stream = BytesIO(b"<< /S /GoTo >>stream\n123456789endstream abcd") class Tst: # to replace pdf strict = False pdf = Tst() pdf.strict = strict if strict: with pytest.raises(PdfReadError) as exc: DictionaryObject.read_from_stream(stream, pdf) assert exc.value.args[0] == "Stream length not defined" else: o = DictionaryObject.read_from_stream(stream, pdf) assert "Stream length not defined" in caplog.text assert o.get_data() == b"123456789" @pytest.mark.parametrize( ("strict", "length", "should_fail"), [ (True, 6, False), (True, 10, False), (True, 4, True), (False, 6, False), (False, 10, False), ], ) def test_dictionaryobject_read_from_stream_stream_stream_valid( strict, length, should_fail ): stream = BytesIO(b"<< /S /GoTo /Length %d >>stream\nBT /F1\nendstream\n" % length) class Tst: # to replace pdf strict = True pdf = Tst() pdf.strict = strict with pytest.raises(PdfReadError) as exc: do = DictionaryObject.read_from_stream(stream, pdf) # TODO: What should happen with the stream? assert do == {"/S": "/GoTo"} if length in (6, 10): assert b"BT /F1" in do.get_data() raise PdfReadError("__ALLGOOD__") assert should_fail ^ (exc.value.args[0] == "__ALLGOOD__") def test_rectangleobject(): ro = RectangleObject((1, 2, 3, 4)) assert ro.lower_left == (1, 2) assert ro.lower_right == (3, 2) assert ro.upper_left == (1, 4) assert ro.upper_right == (3, 4) ro.lower_left = (5, 6) assert ro.lower_left == (5, 6) ro.bottom -= 2 ro.left -= 2 assert ro.lower_left == (3, 4) ro.lower_right = (7, 8) assert ro.lower_right == (7, 8) ro.upper_left = (9, 11) assert ro.upper_left == (9, 11) ro.upper_right = (13, 17) assert ro.upper_right == (13, 17) ro.top += 1 ro.right += 1 assert ro.upper_right == (14, 18) def test_textstringobject_exc(): tso = TextStringObject("foo") assert tso.get_original_bytes() == b"foo" def test_textstringobject_autodetect_utf16(): tso = TextStringObject("foo") tso.autodetect_utf16 = True tso.utf16_bom = codecs.BOM_UTF16_BE assert tso.get_original_bytes() == b"\xfe\xff\x00f\x00o\x00o" tso.utf16_bom = codecs.BOM_UTF16_LE assert tso.get_original_bytes() == b"\xff\xfef\x00o\x00o\x00" assert tso.get_encoded_bytes() == b"\xff\xfef\x00o\x00o\x00" def test_textstringobject__numbers_as_input(): _ = TextStringObject(42) _ = TextStringObject(13.37) def test_remove_child_not_in_tree(): tree = TreeObject() with pytest.raises(ValueError) as exc: tree.remove_child(ChildDummy()) assert exc.value.args[0] == "Removed child does not appear to be a tree item" def test_remove_child_not_in_that_tree(): tree = TreeObject() tree.indirect_reference = NullObject() child = TreeObject() child.indirect_reference = NullObject() with pytest.raises(ValueError) as exc: child.remove_from_tree() assert exc.value.args[0] == "Removed child does not appear to be a tree item" tree.add_child(child, ReaderDummy()) with pytest.raises(ValueError) as exc: tree.remove_child(child) assert exc.value.args[0] == "Removed child is not a member of this tree" def test_remove_child_not_found_in_tree(): class ChildDummy(DictionaryObject): @property def indirect_reference(self) -> "ChildDummy": return self tree = TreeObject() tree.indirect_reference = NullObject() child = ChildDummy(TreeObject()) tree.add_child(child, ReaderDummy()) child2 = ChildDummy(TreeObject()) child2[NameObject("/Parent")] = tree with pytest.raises(ValueError) as exc: tree.remove_child(child2) assert exc.value.args[0] == "Removal couldn't find item in tree" def test_remove_child_found_in_tree(): writer = PdfWriter() # Add Tree tree = TreeObject() writer._add_object(tree) # Add first child # It's important to set a value, otherwise the writer.get_reference will # return the same object when a second child is added. child1 = TreeObject() child1[NameObject("/Foo")] = TextStringObject("bar") child1_ref = writer._add_object(child1) tree.add_child(child1_ref, writer) assert tree[NameObject("/Count")] == 1 assert len(list(tree.children())) == 1 # Add second child child2 = TreeObject() child2[NameObject("/Foo")] = TextStringObject("baz") child2_ref = writer._add_object(child2) tree.add_child(child2_ref, writer) assert tree[NameObject("/Count")] == 2 assert len(list(tree.children())) == 2 # Remove last child tree.remove_child(child2_ref) assert tree[NameObject("/Count")] == 1 assert len(list(tree.children())) == 1 # Add new child child3 = TreeObject() child3[NameObject("/Foo")] = TextStringObject("3") child3_ref = writer._add_object(child3) tree.add_child(child3_ref, writer) assert tree[NameObject("/Count")] == 2 assert len(list(tree.children())) == 2 # Remove first child child1 = tree[NameObject("/First")] tree.remove_child(child1) assert tree[NameObject("/Count")] == 1 assert len(list(tree.children())) == 1 child4 = TreeObject() child4[NameObject("/Foo")] = TextStringObject("4") child4_ref = writer._add_object(child4) tree.add_child(child4_ref, writer) assert tree[NameObject("/Count")] == 2 assert len(list(tree.children())) == 2 child5 = TreeObject() child5[NameObject("/Foo")] = TextStringObject("5") child5_ref = writer._add_object(child5) tree.add_child(child5_ref, writer) assert tree[NameObject("/Count")] == 3 assert len(list(tree.children())) == 3 # Remove middle child child4.remove_from_tree() assert tree[NameObject("/Count")] == 2 assert len(list(tree.children())) == 2 tree.empty_tree() def test_remove_child_in_tree(): pdf = RESOURCE_ROOT / "form.pdf" tree = TreeObject() reader = PdfReader(pdf) writer = PdfWriter() writer._add_object(tree) writer.add_page(reader.pages[0]) writer.add_outline_item("foo", page_number=0) obj = writer._objects[-1] tree.add_child(obj, writer) tree.remove_child(obj) tree.add_child(obj, writer) tree.empty_tree() @pytest.mark.enable_socket @pytest.mark.parametrize( ("url", "name", "caplog_content"), [ ( # parse_content_stream_peek_percentage "https://github.com/user-attachments/files/18381763/tika-985770.pdf", "tika-985770.pdf", "", ), ( # read_inline_image_no_has_q "https://github.com/user-attachments/files/18381775/tika-998719.pdf", "tika-998719.pdf", "", ), ( # read_inline_image_loc_neg_1 "https://github.com/user-attachments/files/18381706/tika-935066.pdf", "tika-935066.pdf", "", ), ( # object_read_from_stream_unicode_error "https://github.com/user-attachments/files/18381750/tika-974966.pdf", "tika-974966.pdf", "", ), ( # dict_read_from_stream "https://github.com/user-attachments/files/18381762/tika-984877.pdf", "tika-984877.pdf", "Multiple definitions in dictionary at byte 0x1084 for key /Length", ), ], ids=[ "parse_content_stream_peek_percentage", "read_inline_image_no_has_q", "read_inline_image_loc_neg_1", "object_read_from_stream_unicode_error", "dict_read_from_stream", ], ) def test_extract_text(caplog, url: str, name: str, caplog_content: str): reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) for page in reader.pages: page.extract_text() if caplog_content == "": assert caplog_content == caplog.text else: assert caplog_content in caplog.text @pytest.mark.slow @pytest.mark.enable_socket def test_text_string_write_to_stream(): url = "https://github.com/user-attachments/files/18381698/tika-924562.pdf" name = "tika-924562.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() writer.clone_document_from_reader(reader) for page in writer.pages: page.compress_content_streams() @pytest.mark.enable_socket def test_bool_repr(tmp_path): url = "https://github.com/user-attachments/files/18381703/tika-932449.pdf" name = "tika-932449.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) write_path = tmp_path / "tmp-fields-report.txt" with open(write_path, "w") as fp: fields = reader.get_fields(fileobj=fp) assert fields assert list(fields.keys()) == ["USGPOSignature"] with open(write_path) as fp: data = fp.read() assert data.startswith( "Field Name: USGPOSignature\nField Type: Signature\nField Flags: 1\n" "Value: {'/Type': '/Sig', '/Filter': '/Adobe.PPKLite', " "'/SubFilter':" ) @pytest.mark.enable_socket def test_issue_997(pdf_file_path): url = ( "https://github.com/py-pdf/pypdf/files/8908874/" "Exhibit_A-2_930_Enterprise_Zone_Tax_Credits_final.pdf" ) name = "gh-issue-997.pdf" merger = PdfWriter() merger.append(BytesIO(get_data_from_url(url, name=name))) # here the error raises with open(pdf_file_path, "wb") as f: merger.write(f) merger.close() # Strict merger = PdfWriter() merger.append(BytesIO(get_data_from_url(url, name=name))) # here the error raises with open(pdf_file_path, "wb") as f: merger.write(f) merger.close() def test_checkboxradiobuttonattributes_opt(): assert "/Opt" in CheckboxRadioButtonAttributes.attributes_dict() def test_name_object_invalid_decode(): charsets = deepcopy(NameObject.CHARSETS) try: NameObject.CHARSETS = ("utf-8",) stream = BytesIO(b"/\x80\x02\x03") # strict: with pytest.raises(PdfReadError) as exc: NameObject.read_from_stream(stream, ReaderDummy(strict=True)) assert "Illegal character in NameObject " in exc.value.args[0] # non-strict: stream.seek(0) NameObject.read_from_stream(stream, ReaderDummy(strict=False)) finally: NameObject.CHARSETS = charsets def test_indirect_object_invalid_read(): stream = BytesIO(b"0 1 s") with pytest.raises(PdfReadError) as exc: IndirectObject.read_from_stream(stream, ReaderDummy()) assert exc.value.args[0] == "Error reading indirect object reference at byte 0x5" def test_create_string_object_utf16_bom(): # utf16-be result = create_string_object( b"\xfe\xff\x00P\x00a\x00p\x00e\x00r\x00P\x00o\x00r\x00t\x00 \x001\x004\x00\x00" ) assert result == "PaperPort 14\x00" assert result.autodetect_utf16 is True assert result.utf16_bom == b"\xfe\xff" assert ( result.get_encoded_bytes() == b"\xfe\xff\x00P\x00a\x00p\x00e\x00r\x00P\x00o\x00r\x00t\x00 \x001\x004\x00\x00" ) # utf16-le result = create_string_object( b"\xff\xfeP\x00a\x00p\x00e\x00r\x00P\x00o\x00r\x00t\x00 \x001\x004\x00\x00\x00" ) assert result == "PaperPort 14\x00" assert result.autodetect_utf16 is True assert result.utf16_bom == b"\xff\xfe" assert ( result.get_encoded_bytes() == b"\xff\xfeP\x00a\x00p\x00e\x00r\x00P\x00o\x00r\x00t\x00 \x001\x004\x00\x00\x00" ) result = TextStringObject( b"\xff\xfeP\x00a\x00p\x00e\x00r\x00P\x00o\x00r\x00t\x00 \x001\x004\x00\x00\x00" ) assert result == "PaperPort 14\x00" assert result.autodetect_utf16 is True assert result.utf16_bom == b"\xff\xfe" assert ( result.get_encoded_bytes() == b"\xff\xfeP\x00a\x00p\x00e\x00r\x00P\x00o\x00r\x00t\x00 \x001\x004\x00\x00\x00" ) # utf16-be without bom result = TextStringObject("Ăż") result.autodetect_utf16 = True result.utf16_bom = b"" assert result.get_encoded_bytes() == b"\x00\xFF" assert result.original_bytes == b"\x00\xFF" def test_create_string_object_force(): assert create_string_object(b"Hello World", []) == "Hello World" assert create_string_object(b"Hello World", {72: "A"}) == "Aello World" assert create_string_object(b"Hello World", "utf8") == "Hello World" @pytest.mark.parametrize( ("value", "expected"), [ ("0.000000", "0.0"), ("0.0", "0.0"), ("1.0", "1"), ("0.123000", "0.123"), ("0.000123000", "0.000123"), ("0.0", "0.0"), ("0", "0.0"), ("1", "1"), ("1.0", "1"), ("1.01", "1.01"), ("1.010", "1.01"), ("0000.0000", "0.0"), ("0.10101010", "0.1010101"), ("50000000000", "50000000000"), ("99900000000000000123", "99900000000000000000"), ("99900000000000000123.456000", "99900000000000000000"), ("0.00000000000000000000123", "0.00000000000000000000123"), ("0.00000123", "0.00000123"), ("0.00000000000000000000123000", "0.00000000000000000000123"), ("-4.6", "-4.6"), # from #1910 # ( # "50032481330523882508234.00000000000000000000123000", # "50032481330523882508234.00000000000000000000123", # ), # ( # "928457298572093487502198745102973402987412908743.75249875981374981237498213740000", # "928457298572093487502198745102973402987412908743.7524987598137498123749821374", # ), ], ) def test_float_object_decimal_to_string(value, expected): assert repr(FloatObject(value)) == expected def test_cloning(caplog): writer = PdfWriter() with pytest.raises(Exception) as exc: PdfObject().clone(writer) assert "PdfObject does not implement .clone so far" in exc.value.args[0] obj1 = DictionaryObject() obj1.indirect_reference = None n = len(writer._objects) obj2 = obj1.clone(writer) assert len(writer._objects) == n + 1 obj3 = obj2.clone(writer) assert len(writer._objects) == n + 1 assert obj2.indirect_reference == obj3.indirect_reference obj3 = obj2.indirect_reference.clone(writer) assert len(writer._objects) == n + 1 assert obj2.indirect_reference == obj3.indirect_reference assert ( obj2.indirect_reference == obj2._reference_clone(obj2, writer).indirect_reference ) assert len(writer._objects) == n + 1 assert obj2.indirect_reference == obj3.indirect_reference obj3 = obj2.indirect_reference.clone(writer, True) assert len(writer._objects) == n + 2 assert obj2.indirect_reference != obj3.indirect_reference arr1 = ArrayObject([obj2]) arr2 = arr1.clone(writer) arr3 = arr2.clone(writer) assert arr2 == arr3 obj10 = StreamObject() arr1 = ArrayObject([obj10]) obj11 = obj10.clone(writer) assert arr1[0] == obj11 obj20 = DictionaryObject( {NameObject("/Test"): NumberObject(1), NameObject("/Test2"): StreamObject()} ) obj21 = obj20.clone(writer, ignore_fields=None) assert "/Test" in obj21 assert isinstance(obj21.get("/Test2"), IndirectObject) @pytest.mark.enable_socket def test_append_with_indirectobject_not_pointing(caplog): """ Reported in #1631 the object 43 0 is not invalid """ url = "https://github.com/py-pdf/pypdf/files/10729142/document.pdf" name = "tst_iss1631.pdf" data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data, strict=False) writer = PdfWriter() writer.append(reader) assert "Object 43 0 not defined." in caplog.text @pytest.mark.enable_socket def test_iss1615_1673(): """ Test cases where /N is not indicating chains of objects test also where /N,... are not part of chains """ # #1615 url = "https://github.com/py-pdf/pypdf/files/10671366/graph_letter.pdf" name = "graph_letter.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() writer.append(reader) assert ( "/N" in writer.pages[0]["/Annots"][0] .get_object()["/AP"]["/N"]["/Resources"]["/ColorSpace"]["/Cs1"][1] .get_object() ) # #1673 url = "https://github.com/py-pdf/pypdf/files/10848750/budgeting-loan-form-sf500.pdf" name = "budgeting-loan-form-sf500.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() writer.clone_document_from_reader(reader) @pytest.mark.enable_socket def test_destination_withoutzoom(): """Cf issue #1832""" url = "https://github.com/user-attachments/files/15605648/2021_book_security.pdf" name = "2021_book_security.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.outline out = BytesIO() writer = PdfWriter(clone_from=reader) writer.write(out) def test_encodedstream_set_data(): """ EncodedStreamObject.set_data to extend data stream works. Checks also the flate_encode. """ pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) co = reader.pages[0]["/Contents"][0].get_object() co.set_data(b"%hello\n" + co.get_data()) assert b"hello" in co.get_data() b = BytesIO() co.write_to_stream(b) b.seek(0) aa = read_object(b, None) assert b"hello" in aa.get_data() assert aa["/Filter"] == "/FlateDecode" assert "/DecodeParms" not in aa bb = aa.flate_encode() assert b"hello" in bb.get_data() assert bb["/Filter"] == ["/FlateDecode", "/FlateDecode"] assert str(bb["/DecodeParms"]) == "[NullObject, NullObject]" bb[NameObject("/Test")] = NameObject("/MyTest") cc = bb.flate_encode() assert bb["/Filter"] == ["/FlateDecode", "/FlateDecode"] assert b"hello" in cc.get_data() assert cc["/Filter"] == ["/FlateDecode", "/FlateDecode", "/FlateDecode"] assert str(cc["/DecodeParms"]) == "[NullObject, NullObject, NullObject]" assert cc[NameObject("/Test")] == "/MyTest" with pytest.raises(TypeError): aa.set_data("toto") aa[NameObject("/Filter")] = NameObject("/JPXEncode") with pytest.raises(PdfReadError): aa.set_data(b"toto") @pytest.mark.enable_socket def test_set_data_2(): """ Modify a stream not yet loaded and where the filter is ["/FlateDecode"] """ url = "https://github.com/user-attachments/files/16796095/f5471sm-2.pdf" name = "iss2780.pdf" writer = PdfWriter(BytesIO(get_data_from_url(url, name=name))) writer.root_object["/AcroForm"]["/XFA"][7].set_data(b"test") assert writer.root_object["/AcroForm"]["/XFA"][7].get_object()["/Filter"] == [ "/FlateDecode" ] assert writer.root_object["/AcroForm"]["/XFA"][7].get_object().get_data() == b"test" @pytest.mark.enable_socket def test_calling_indirect_objects(): """Cope with cases where attributes/items are called from indirectObject""" url = "https://github.com/user-attachments/files/15605648/2021_book_security.pdf" name = "2021_book_security.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.trailer.get("/Info")["/Creator"] reader.pages[0]["/Contents"][0].get_data() writer = PdfWriter(clone_from=reader) ind = writer._add_object(writer) assert ind.fileobj == writer.fileobj with pytest.raises(AttributeError): ind.not_existing_attribute # create an IndirectObject referencing an IndirectObject. writer._objects.append(writer.pages[0].indirect_reference) ind = IndirectObject(len(writer._objects), 0, writer) with pytest.raises(PdfStreamError): ind["/Type"] @pytest.mark.enable_socket def test_indirect_object_page_dimensions(): url = "https://github.com/py-pdf/pypdf/files/13302338/Zymeworks_Corporate.Presentation_FINAL1101.pdf.pdf" name = "issue2287.pdf" data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data, strict=False) mediabox = reader.pages[0].mediabox assert mediabox == RectangleObject((0, 0, 792, 612)) def test_indirect_object_contains(): writer = PdfWriter() indirect_object = IndirectObject(1, 0, writer) assert "foo" not in indirect_object assert "/Producer" in indirect_object def test_indirect_object_iter(): writer = PdfWriter() indirect_object = IndirectObject(1, 0, writer) assert "foo" not in list(indirect_object) assert "/Producer" in list(indirect_object) def test_array_operators(): a = ArrayObject( [ NumberObject(1), NumberObject(2), NumberObject(3), NumberObject(4), ] ) b = a + 5 assert isinstance(b, ArrayObject) assert b == [1, 2, 3, 4, 5] assert a == [1, 2, 3, 4] a -= 2 a += "abc" a -= (3, 4) a += ["d", "e"] a += BooleanObject(True) assert a == [1, "abc", "d", "e", True] a += "/toto" assert isinstance(a[-1], NameObject) assert isinstance(a[1], TextStringObject) a += b"1234" assert a[-1] == ByteStringObject(b"1234") la = len(a) a -= 300 assert len(a) == la def test_unitary_extract_inline_buffer_invalid(): with pytest.raises(PdfReadError): extract_inline_AHx(BytesIO()) with pytest.raises(PdfReadError): extract_inline_AHx(BytesIO(4095 * b"00" + b" ")) with pytest.raises(PdfReadError): extract_inline_AHx(BytesIO(b"00")) with pytest.raises(PdfReadError): extract_inline_A85(BytesIO()) with pytest.raises(PdfReadError): extract_inline_A85(BytesIO(a85encode(b"1"))) with pytest.raises(PdfReadError): extract_inline_A85(BytesIO(a85encode(b"1") + b"~> Q")) with pytest.raises(PdfReadError): extract_inline_A85(BytesIO(a85encode(b"1234578" * 990))) with pytest.raises(PdfReadError): extract_inline_RL(BytesIO()) with pytest.raises(PdfReadError): extract_inline_RL(BytesIO(b"\x01\x01\x80")) with pytest.raises(PdfReadError): extract_inline_DCT(BytesIO(b"\xFF\xD9")) def test_unitary_extract_inline(): # AHx b = 16000 * b"00" assert len(extract_inline_AHx(BytesIO(b + b" EI"))) == len(b) with pytest.raises(PdfReadError): extract_inline_AHx(BytesIO(b + b"> ")) # RL b = 8200 * b"\x00\xAB" + b"\x80" assert len(extract_inline_RL(BytesIO(b + b" EI"))) == len(b) # default # EIDD instead of EI; using A85 b = b"""1 0 0 1 0 0 cm BT /F1 12 Tf 14.4 TL ET\nq 100 0 0 100 100 100 cm BI\n/W 16 /H 16 /BPC 8 /CS /RGB /F [/A85 /Fl]\nID Gar8O(o6*is8QV#;;JAuTq2lQ8J;%6#\'d5b"Q[+ZD?\'\\+CGj9~> EIDD Q\nBT 1 0 0 1 200 100 Tm (Test) Tj T* ET\n \n""" ec = DecodedStreamObject() ec.set_data(b) co = ContentStream(ec, None) with pytest.raises(PdfReadError) as exc: co.operations assert "EI stream not found" in exc.value.args[0] # EIDD instead of EI; using /Fl (default extraction) b = b"""1 0 0 1 0 0 cm BT /F1 12 Tf 14.4 TL ET\nq 100 0 0 100 100 100 cm BI\n/W 16 /H 16 /BPC 8 /CS /RGB /F /Fl \nID Gar8O(o6*is8QV#;;JAuTq2lQ8J;%6#\'d5b"Q[+ZD?\'\\+CGj9~> EIDD Q\nBT 1 0 0 1 200 100 Tm (Test) Tj T* ET\n \n""" ec = DecodedStreamObject() ec.set_data(b) co = ContentStream(ec, None) with pytest.raises(PdfReadError) as exc: co.operations assert "Unexpected end of stream" in exc.value.args[0] b = b"""1 0 0 1 0 0 cm BT /F1 12 Tf 14.4 TL ET\nq 100 0 0 100 100 100 cm BI\n/W 16 /H 16 /BPC 8 /CS /RGB /F /Fl \nID Gar8O(o6*is8QV#;;JAuTq2lQ8J;%6#\'d5b"Q[+ZD?\'\\+CGj9~>EI BT\nQ\nBT 1 0 0 1 200 100 Tm (Test) Tj T* ET\n \n""" ec = DecodedStreamObject() ec.set_data(b) co = ContentStream(ec, None) with pytest.raises(PdfReadError) as exc: co.operations assert "Unexpected end of stream" in exc.value.args[0] b = b"""1 0 0 1 0 0 cm BT /F1 12 Tf 14.4 TL ET\nq 100 0 0 100 100 100 cm BI\n/W 4 /H 4 /CS /G \nID abcdefghijklmnopEI Q\nQ\nBT 1 0 0 1 200 100 Tm (Test) Tj T* ET\n \n""" ec = DecodedStreamObject() ec.set_data(b) co = ContentStream(ec, None) assert co.operations[7][0]["data"] == b"abcdefghijklmnop" b = b"""1 0 0 1 0 0 cm BT /F1 12 Tf 14.4 TL ET\nq 100 0 0 100 100 100 cm BI\n/W 4 /H 4 \nID abcdefghijklmnopEI Q\nQ\nBT 1 0 0 1 200 100 Tm (Test) Tj T* ET\n \n""" ec = DecodedStreamObject() ec.set_data(b) co = ContentStream(ec, None) assert co.operations[7][0]["data"] == b"abcdefghijklmnop" def test_missing_hashbin(): assert NullObject().hash_bin() == hash((NullObject,)) assert hash(NullObject()) == NullObject().hash_bin() t = ByteStringObject(b"123") assert t.hash_bin() == hash((ByteStringObject, b"123")) def test_is_null_or_none(): assert is_null_or_none(NullObject()) assert not is_null_or_none(PdfObject()) reader = PdfReader(RESOURCE_ROOT / "crazyones.pdf") # used with get assert is_null_or_none(reader.root_object.get("/do_no_exist")) # object unknown... assert is_null_or_none(IndirectObject(99999, 0, reader).get_object()) # ... or which has been replaced with NullObject writer = PdfWriter(reader) writer.pages[0]["/Contents"].append(writer._add_object(NullObject())) assert is_null_or_none(writer.pages[0]["/Contents"][-1]) def test_coverage_arrayobject(): writer = PdfWriter() a = ArrayObject([1]) assert isinstance(a.replicate(writer)[0], int) assert isinstance(a.clone(writer)[0], int) a.indirect_reference = IndirectObject(1, 0, writer) assert isinstance(a.clone(writer)[0], int) r = PdfReader(RESOURCE_ROOT / "crazyones.pdf") a = ArrayObject([r.pages[0]["/Contents"][0].get_object()]) aa = a.clone(writer) assert isinstance(aa[0], IndirectObject) for k, v in aa.items(): assert isinstance(k, int) assert isinstance(v, PdfObject) def test_coverage_streamobject(): writer = PdfWriter() s = StreamObject() del s.decoded_self s.replicate(writer) s.clone(writer) co = ContentStream(None, None) co.replicate(writer) co.clone(writer, False, None) co.indirect_reference = IndirectObject(1, 0, writer) assert co == co.clone(writer) r = PdfReader(RESOURCE_ROOT / "crazyones.pdf") co = r.pages[0].get_contents() co[NameObject("/testkey")] = NameObject("/test") co.decoded_self = None assert "/testkey" in co.replicate(writer) co = r.pages[0].get_contents() co[NameObject("/testkey")] = NameObject("/test") co.decoded_self = DecodedStreamObject() assert "/testkey" in co.replicate(writer) def test_contentstream_arrayobject_containing_nullobject(caplog): stream_object = DecodedStreamObject() stream_object.set_data(b"Hello World!") input_stream = ArrayObject([NullObject(), stream_object]) content_stream = ContentStream(stream=input_stream, pdf=None) assert content_stream.get_data() == b"Hello World!\n" assert caplog.text == "" @pytest.mark.enable_socket def test_build_link__go_to_action_without_destination(): reader = PdfReader(BytesIO(get_data_from_url(name="issue-3419.pdf"))) writer = PdfWriter() for page in reader.pages: writer.add_page(page) assert len(writer.pages) == len(reader.pages) @pytest.mark.enable_socket def test_dictionaryobject__length_0_stream(): """Test for issue #3052.""" url = "https://github.com/user-attachments/files/18734105/correct.pdf" name = "issue3052.pdf" writer = PdfWriter(clone_from=BytesIO(get_data_from_url(url, name=name))) output = BytesIO() writer.write(output) assert b"\n8 0 obj\n<<\n/Length 0\n>>\nstream\n\nendstream\nendobj\n" in output.getvalue() pypdf-6.1.2/tests/test_images.py000066400000000000000000000520201507516550200166670ustar00rootroot00000000000000""" Tests which ensure that image extraction works properly go here. Typically, tests in here should compare the extracted images count, names, and/or the actual image data with the expected value. """ from io import BytesIO from pathlib import Path from typing import Union from unittest import mock from zipfile import ZipFile import pytest from PIL import Image, ImageChops, ImageDraw from pypdf import PageObject, PdfReader, PdfWriter from pypdf.filters import JBIG2Decode from pypdf.generic import ContentStream, NameObject, NullObject from . import get_data_from_url TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" SAMPLE_ROOT = PROJECT_ROOT / "sample-files" def open_image(path: Union[Path, Image.Image, BytesIO]) -> Image.Image: if isinstance(path, Image.Image): img = path else: if isinstance(path, Path): assert path.exists() with Image.open(path) as img: img = ( img.copy() ) # Opened image should be copied to avoid issues with file closing return img def image_similarity( path1: Union[Path, Image.Image, BytesIO], path2: Union[Path, Image.Image, BytesIO] ) -> float: """ Check image similarity. A value of "0" means the images are different. A value of 1 means they are identical. A value above 0.9 means they are almost the same. This can be used to ensure visual similarity. """ # Open the images using Pillow image1 = open_image(path1) image2 = open_image(path2) # Check if the images have the same dimensions if image1.size != image2.size: return 0 # Check if the color modes are the same if image1.mode != image2.mode: return 0 # Calculate the Mean Squared Error (MSE) diff = ImageChops.difference(image1, image2) pixels = list(diff.getdata()) if isinstance(pixels[0], tuple): mse = sum(sum((c / 255.0) ** 2 for c in p) for p in pixels) / ( len(pixels) * len(pixels[0]) ) else: mse = sum((p / 255.0) ** 2 for p in pixels) / len(pixels) return 1 - mse @pytest.mark.samples def test_image_similarity_one(): path_a = SAMPLE_ROOT / "018-base64-image/page-0-QuickPDFImd32aa1ab.png" path_b = path_a assert image_similarity(path_a, path_b) == 1 @pytest.mark.samples def test_image_similarity_zero(): path_a = SAMPLE_ROOT / "018-base64-image/page-0-QuickPDFImd32aa1ab.png" path_b = SAMPLE_ROOT / "009-pdflatex-geotopo/page-23-Im2.png" assert image_similarity(path_a, path_b) == 0 @pytest.mark.samples def test_image_similarity_mid(): path_a = SAMPLE_ROOT / "018-base64-image/page-0-QuickPDFImd32aa1ab.png" img_b = Image.open(path_a) draw = ImageDraw.Draw(img_b) # Fill the rectangle with black color draw.rectangle([0, 0, 100, 100], fill=(0, 0, 0)) sim1 = image_similarity(path_a, img_b) assert sim1 > 0.9 assert sim1 > 0 assert sim1 < 1 draw.rectangle([0, 0, 200, 200], fill=(0, 0, 0)) sim2 = image_similarity(path_a, img_b) assert sim2 < sim1 assert sim2 > 0 @pytest.mark.enable_socket def test_image_new_property(): name = "pdf_font_garbled.pdf" reader = PdfReader(BytesIO(get_data_from_url(name=name))) assert reader.pages[0].images.keys() == [ "/I0", "/I1", "/I2", "/I3", "/I4", "/I5", "/I6", "/I7", "/I8", "/I9", ["/TPL1", "/Image5"], ["/TPL2", "/Image53"], ["/TPL2", "/Image37"], ["/TPL2", "/Image49"], ["/TPL2", "/Image51"], ["/TPL2", "/Image39"], ["/TPL2", "/Image57"], ["/TPL2", "/Image55"], ["/TPL2", "/Image43"], ["/TPL2", "/Image30"], ["/TPL2", "/Image22"], ["/TPL2", "/Image41"], ["/TPL2", "/Image47"], ["/TPL2", "/Image45"], ["/TPL3", "/Image65"], ["/TPL3", "/Image30"], ["/TPL3", "/Image61"], ["/TPL4", "/Image30"], ["/TPL5", "/Image30"], ["/TPL6", "/Image30"], ["/TPL7", "/Image30"], ["/TPL8", "/Image30"], ["/TPL9", "/Image30"], ["/TPL10", "/Image30"], ["/TPL11", "/Image30"], ["/TPL12", "/Image30"], ] assert len(reader.pages[0].images.items()) == 36 assert reader.pages[0].images[0].name == "I0.png" expected_image_url = "https://github.com/user-attachments/assets/3bf25760-2113-4e25-b4c2-fc1d3a84a263" expected_image_name = "pdf_font_garbled_image30.png" expected_image_data = BytesIO(get_data_from_url(url=expected_image_url, name=expected_image_name)) assert image_similarity( expected_image_data, reader.pages[0].images[-1].image ) == 1 assert reader.pages[0].images["/TPL1", "/Image5"].image.format == "JPEG" assert ( reader.pages[0].images["/I0"].indirect_reference.get_object() == reader.pages[0]["/Resources"]["/XObject"]["/I0"] ) list(reader.pages[0].images[0:2]) with pytest.raises(TypeError): reader.pages[0].images[b"0"] with pytest.raises(IndexError): reader.pages[0].images[9999] # just for test coverage: with pytest.raises(KeyError): reader.pages[0]._get_image(["test"], reader.pages[0]) assert list(PageObject(None, None).images) == [] @pytest.mark.parametrize( ("src", "page_index", "image_key", "expected"), [ ( SAMPLE_ROOT / "009-pdflatex-geotopo/GeoTopo.pdf", 23, "/Im2", SAMPLE_ROOT / "009-pdflatex-geotopo/page-23-Im2.png", ), ( SAMPLE_ROOT / "003-pdflatex-image/pdflatex-image.pdf", 0, "/Im1", SAMPLE_ROOT / "003-pdflatex-image/page-0-Im1.jpg", ), ( SAMPLE_ROOT / "018-base64-image/base64image.pdf", 0, "/QuickPDFImd32aa1ab", SAMPLE_ROOT / "018-base64-image/page-0-QuickPDFImd32aa1ab.png", ), ( SAMPLE_ROOT / "019-grayscale-image/grayscale-image.pdf", 0, "/X0", SAMPLE_ROOT / "019-grayscale-image/page-0-X0.png", ), ], ids=[ "009-pdflatex-geotopo/page-23-Im2.png", "003-pdflatex-image/page-0-Im1.jpg", "018-base64-image/page-0-QuickPDFImd32aa1ab.png", "019-grayscale-image/page-0-X0.png", ], ) @pytest.mark.samples def test_image_extraction(src, page_index, image_key, expected): reader = PdfReader(src) actual_image = reader.pages[page_index].images[image_key] if not expected.exists(): # A little helper for test generation with open(f"page-{page_index}-{actual_image.name}", "wb") as fp: fp.write(actual_image.data) assert image_similarity(BytesIO(actual_image.data), expected) >= 0.99 @pytest.mark.enable_socket @pytest.mark.timeout(30) def test_loop_in_image_keys(): """Cf #2077""" reader = PdfReader(BytesIO(get_data_from_url(name="iss2077.pdf"))) reader.pages[0]["/Resources"]["/XObject"][NameObject("/toto")] = NullObject() reader.pages[0].images.keys() @pytest.mark.enable_socket def test_devicen_cmyk_black_only(): """Cf #2321""" url = "https://github.com/py-pdf/pypdf/files/13501846/Addressing_Adversarial_Attacks.pdf" name = "iss2321.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) url = "https://github.com/py-pdf/pypdf/assets/4083478/cc2dabc1-86e6-4179-a8a4-2b0efea124be" name = "iss2321_img0.pdf" img = Image.open(BytesIO(get_data_from_url(url, name=name))) assert image_similarity(reader.pages[5].images[0].image, img) >= 0.99 url = "https://github.com/py-pdf/pypdf/assets/4083478/6b64a949-42be-40d5-9eea-95707f350d89" name = "iss2321_img1.pdf" img = Image.open(BytesIO(get_data_from_url(url, name=name))) assert image_similarity(reader.pages[10].images[0].image, img) >= 0.99 @pytest.mark.enable_socket def test_bi_in_text(): """Cf #2456""" url = "https://github.com/py-pdf/pypdf/files/14322910/BI_text_with_one_image.pdf" name = "BI_text_with_one_image.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert reader.pages[0].images.keys() == ["~0~"] assert reader.pages[0].images[0].name == "~0~.png" @pytest.mark.enable_socket def test_cmyk_no_filter(): """Cf #2522""" url = "https://github.com/py-pdf/pypdf/files/14614887/out3.pdf" name = "iss2522.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.pages[0].images[0].image @pytest.mark.enable_socket def test_separation_1byte_to_rgb_inverted(): """Cf #2343""" url = "https://github.com/py-pdf/pypdf/files/13679585/test2_P038-038.pdf" name = "iss2343.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) url = "https://github.com/py-pdf/pypdf/assets/4083478/b7f41897-96ef-4ea6-b165-5ef307a92b87" name = "iss2343.png" img = Image.open(BytesIO(get_data_from_url(url, name=name))) assert image_similarity(reader.pages[0].images[0].image, img) >= 0.99 obj = reader.pages[0].images[0].indirect_reference.get_object() obj.set_data(obj.get_data() + b"\x00") with pytest.raises(ValueError): reader.pages[0].images[0] @pytest.mark.enable_socket def test_data_with_lf(): """Cf #2343""" url = "https://github.com/py-pdf/pypdf/files/13946477/panda.pdf" name = "iss2343b.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) url = "https://github.com/py-pdf/pypdf/assets/4083478/1120b0cf-a67a-403f-aa1a-9a191cbc087f" name = "iss2343b0.png" img = Image.open(BytesIO(get_data_from_url(url, name=name))) assert image_similarity(reader.pages[8].images[9].image, img) == 1.0 @pytest.mark.enable_socket def test_oserror(): """Cf #2265""" url = "https://github.com/py-pdf/pypdf/files/13127130/Binance.discovery.responses.2.gov.uscourts.dcd.256060.140.1.pdf" name = "iss2265.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.pages[2].images[1] # Due to errors in translation in pillow we may not get # the correct image. Therefore we cannot use `image_similarity`. @pytest.mark.parametrize( ("pdf", "pdf_name", "images", "images_name", "filtr"), [ ( "https://github.com/py-pdf/pypdf/files/13127197/FTX.Claim.SC30.01072023101624File595287144.pdf", "iss2266a.pdf", "https://github.com/py-pdf/pypdf/files/14967061/iss2266a_images.zip", "iss2266a_images.zip", ((0, 0), (1, 0), (4, 0), (9, 0)), # random pick-up to speed up test ), ( "https://github.com/py-pdf/pypdf/files/13127242/FTX.Claim.Skybridge.Capital.30062023113350File971325116.pdf", "iss2266b.pdf", "https://github.com/py-pdf/pypdf/files/14967099/iss2266b_images.zip", "iss2266b_images.zip", ((0, 0), (1, 0), (4, 0), (9, 0)), # random pick-up to speed up test ), ], ) @pytest.mark.enable_socket def test_corrupted_jpeg_iss2266(pdf, pdf_name, images, images_name, filtr): """ Code to create zipfile: import pypdf;zipfile with pypdf.PdfReader("____inputfile___") as r: with zipfile.ZipFile("__outputzip___","w") as z: for p in r.pages: for ii,i in enumerate(p.images): print(i.name) b=BytesIO() i.image.save(b,"JPEG") z.writestr(f"image_{p.page_number}_{ii}_{i.name}",b.getbuffer()) """ url = pdf name = pdf_name reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) url = images name = images_name print(pdf_name, images_name) # noqa: T201 with ZipFile(BytesIO(get_data_from_url(url, name=name)), "r") as zf: for fn in zf.namelist(): sp = fn.split("_") p, i = int(sp[1]), int(sp[2]) if filtr is not None and (p, i) not in filtr: continue print(fn) # noqa: T201 img = Image.open(BytesIO(zf.read(fn))) assert image_similarity(reader.pages[p].images[i].image, img) >= 0.99 @pytest.mark.enable_socket @pytest.mark.timeout(30) def test_large_compressed_image(): url = "https://github.com/py-pdf/pypdf/files/15306199/file_with_large_compressed_image.pdf" reader = PdfReader( BytesIO(get_data_from_url(url, name="file_with_large_compressed_image.pdf")) ) list(reader.pages[0].images) @pytest.mark.enable_socket def test_ff_fe_starting_lut(): """Cf issue #2660""" url = "https://github.com/py-pdf/pypdf/files/15385628/original_before_merge.pdf" name = "iss2660.pdf" writer = PdfWriter(BytesIO(get_data_from_url(url, name=name))) b = BytesIO() writer.write(b) reader = PdfReader(b) url = "https://github.com/py-pdf/pypdf/assets/4083478/6150700d-87fd-43a2-8695-c2c05a44838c" name = "iss2660.png" img = Image.open(BytesIO(get_data_from_url(url, name=name))) assert image_similarity(writer.pages[1].images[0].image, img) == 1.0 assert image_similarity(reader.pages[1].images[0].image, img) == 1.0 @pytest.mark.enable_socket def test_inline_image_extraction(): """Cf #2598""" url = "https://github.com/py-pdf/pypdf/files/14982414/lebo102.pdf" name = "iss2598.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) # there is no error because images are correctly extracted reader.pages[1].extract_text() reader.pages[2].extract_text() reader.pages[3].extract_text() url = "https://github.com/py-pdf/pypdf/files/15210011/Pages.62.73.from.0560-22_WSP.Plan_July.2022_Version.1.pdf" name = "iss2598a.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.pages[0].extract_text() reader.pages[1].extract_text() url = "https://github.com/mozilla/pdf.js/raw/master/test/pdfs/issue14256.pdf" name = "iss2598b.pdf" writer = PdfWriter(BytesIO(get_data_from_url(url, name=name))) url = "https://github.com/py-pdf/pypdf/assets/4083478/71bc5053-cfc7-44ba-b7be-8e2333e2c749" name = "iss2598b.png" img = Image.open(BytesIO(get_data_from_url(url, name=name))) for i in range(8): assert image_similarity(writer.pages[0].images[i].image, img) == 1 writer.pages[0].extract_text() # check recalculation of inline images assert writer.pages[0].inline_images is not None writer.pages[0].merge_scaled_page(writer.pages[0], 0.25) assert writer.pages[0].inline_images is None reader = PdfReader(RESOURCE_ROOT / "imagemagick-ASCII85Decode.pdf") writer.pages[0].merge_page(reader.pages[0]) assert list(writer.pages[0].images.keys()) == [ "/Im0", "~0~", "~1~", "~2~", "~3~", "~4~", "~5~", "~6~", "~7~", "~8~", "~9~", "~10~", "~11~", "~12~", "~13~", "~14~", "~15~", ] url = "https://github.com/py-pdf/pypdf/files/15233597/bug1065245.pdf" name = "iss2598c.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) url = "https://github.com/py-pdf/pypdf/assets/4083478/bfb221be-11bd-46fe-8129-55a58088a4b6" name = "iss2598c.jpg" img = Image.open(BytesIO(get_data_from_url(url, name=name))) assert image_similarity(reader.pages[0].images[0].image, img) >= 0.99 url = "https://github.com/py-pdf/pypdf/files/15282904/tt.pdf" name = "iss2598d.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) url = "https://github.com/py-pdf/pypdf/assets/4083478/1a770e1b-9ad2-4125-89ae-6069992dda23" name = "iss2598d.png" img = Image.open(BytesIO(get_data_from_url(url, name=name))) assert image_similarity(reader.pages[0].images[0].image, img) == 1 @pytest.mark.enable_socket def test_extract_image_from_object(caplog): url = "https://github.com/py-pdf/pypdf/files/15176076/B2.pdf" name = "iss2613.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) image = reader.pages[0]["/Resources"]["/Pattern"]["/P1"]["/Resources"]["/XObject"][ "/X1" ].decode_as_image() assert isinstance(image, Image.Image) with pytest.raises(Exception): co = reader.pages[0].get_contents() co.decode_as_image() assert "does not seem to be an Image" in caplog.text caplog.clear() co.indirect_reference = "for_test" with pytest.raises(Exception): co = reader.pages[0].get_contents() co.decode_as_image() assert "does not seem to be an Image" in caplog.text @pytest.mark.enable_socket def test_4bits_images(caplog): url = "https://github.com/user-attachments/files/16624406/tt.pdf" name = "iss2411.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) url = "https://github.com/user-attachments/assets/53058564-9a28-4e4a-818f-a6528013d7dc" name = "iss2411.png" img = Image.open(BytesIO(get_data_from_url(url, name=name))) assert image_similarity(reader.pages[0].images[1].image, img) == 1.0 @pytest.mark.enable_socket def test_no_filter_with_colorspace_as_list(): """Tests for #2998""" url = "https://github.com/user-attachments/files/18058571/9bf7a2e2-72c8-4ac1-b8ae-164df16c8cef.pdf" name = "iss2998.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) page = reader.pages[0] page.images.items() def test_contentstream__read_inline_image__fallback_is_successful(): stream = ContentStream(stream=None, pdf=None) stream.set_data( b"""Q q 9.6 0 0 4.8 5523.6 1031 cm BI /CS /RGB /W 2 /H 1 /BPC 8 ID \x8b\x8b\x8b\xfe\xfe\xfe EI Q /R413 gs """ ) page = PageObject(pdf=None) with mock.patch.object(page, "get_contents", return_value=stream): images = page._get_inline_images() assert list(images) == ["~0~"] assert images["~0~"].data == ( b"\x89PNG\r\n\x1a\n\x00\x00\x00\rIHDR\x00\x00\x00\x02\x00\x00\x00\x01\x08\x02\x00\x00\x00{@\xe8\xdd\x00\x00\x00\x0f" b"IDATx\x9cc\xe8\xee\xee\xfe\xf7\xef\x1f\x00\x0e \x04\x9cpr_\x96\x00\x00\x00\x00IEND\xaeB`\x82" ) @pytest.mark.enable_socket def test_inline_image_containing_ei_in_body(): """Tests for #3107""" expected = """\nID ><8d>ÂŁ^H<8e><8b>¢AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA¡^BĂŞMEI E^N^^<8a>^AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA^D <8b>²: AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA5>^D Ă©^EAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAD<98>AAAAAA<8d><82> AAAAAAAA^B EI\nQ\n""".encode("latin1") # noqa: E501 url = "https://github.com/user-attachments/files/18943249/testing.pdf" name = "issue3107.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter(clone_from=reader) for page in writer.pages: page.transfer_rotation_to_content() output = BytesIO() writer.write(output) assert expected in output.getvalue() @pytest.mark.enable_socket @pytest.mark.skipif(condition=not JBIG2Decode._is_binary_compatible(), reason="Requires recent jbig2dec") def test_jbig2decode(): url = "https://github.com/py-pdf/pypdf/files/12090692/New.Jersey.Coinbase.staking.securities.charges.2023-0606_Coinbase-Penalty-and-C-D.pdf" name = "jbig2.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) page = reader.pages[0] image = next(iter(page.images)) assert image.image.size == (5138, 6630) assert image.image.mode == "1" assert image.image.format == "PNG" url = "https://github.com/user-attachments/assets/d6f88c80-a2e0-4ea9-b1e0-34442041d004" name = "jbig2.png" img = Image.open(BytesIO(get_data_from_url(url, name=name))) assert image_similarity(image.image, img) >= 0.999 @pytest.mark.enable_socket @pytest.mark.skipif(condition=not JBIG2Decode._is_binary_compatible(), reason="Requires recent jbig2dec") def test_jbig2decode__jbig2globals(): url = "https://github.com/user-attachments/files/20119148/out.pdf" name = "jbig2_globals.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) page = reader.pages[0] image = next(iter(page.images)) assert image.image.size == (1067, 1067) assert image.image.mode == "1" assert image.image.format == "PNG" url = "https://github.com/user-attachments/assets/7ac41ee3-9c13-44cf-aa74-8f106287e354" name = "jbig2_globals.png" img = Image.open(BytesIO(get_data_from_url(url, name=name))) # Wrong image: 0.9618265964800714 assert image_similarity(image.image, img) >= 0.999 @pytest.mark.enable_socket def test_get_ids_image__resources_is_none(): url = "https://github.com/user-attachments/files/18381726/tika-957721.pdf" name = "tika-957721.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) page = reader.pages[2] assert list(page.images.items()) == [] pypdf-6.1.2/tests/test_javascript.py000066400000000000000000000032461507516550200175760ustar00rootroot00000000000000"""Test topics around the usage of JavaScript in PDF documents.""" from pathlib import Path from typing import Any import pytest from pypdf import PdfReader, PdfWriter # Configure path environment TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" @pytest.fixture def pdf_file_writer(): reader = PdfReader(RESOURCE_ROOT / "issue-604.pdf") writer = PdfWriter() writer.append_pages_from_reader(reader) return writer def test_add_js(pdf_file_writer): pdf_file_writer.add_js("this.print({bUI:true,bSilent:false,bShrinkToFit:true});") assert ( "/Names" in pdf_file_writer._root_object ), "add_js should add a name catalog in the root object." assert ( "/JavaScript" in pdf_file_writer._root_object["/Names"] ), "add_js should add a JavaScript name tree under the name catalog." def test_added_js(pdf_file_writer): def get_javascript_name() -> Any: assert "/Names" in pdf_file_writer._root_object assert "/JavaScript" in pdf_file_writer._root_object["/Names"] assert "/Names" in pdf_file_writer._root_object["/Names"]["/JavaScript"] return pdf_file_writer._root_object["/Names"]["/JavaScript"]["/Names"][ -2 ] # return -2 in order to get the latest javascript pdf_file_writer.add_js("this.print({bUI:true,bSilent:false,bShrinkToFit:true});") first_js = get_javascript_name() pdf_file_writer.add_js("this.print({bUI:true,bSilent:false,bShrinkToFit:true});") second_js = get_javascript_name() assert ( first_js != second_js ), "add_js should add to the previous script in the catalog." pypdf-6.1.2/tests/test_merger.py000066400000000000000000000353451507516550200167160ustar00rootroot00000000000000"""Test merging PDF functionality.""" import sys from io import BytesIO from pathlib import Path import pytest import pypdf from pypdf import PdfReader, PdfWriter from pypdf.generic import Destination, Fit from . import get_data_from_url TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" sys.path.append(str(PROJECT_ROOT)) def merger_operate(merger): pdf_path = RESOURCE_ROOT / "crazyones.pdf" outline = RESOURCE_ROOT / "pdflatex-outline.pdf" pdf_forms = RESOURCE_ROOT / "pdflatex-forms.pdf" pdf_pw = RESOURCE_ROOT / "libreoffice-writer-password.pdf" # string path: merger.append(pdf_path) merger.append(outline) merger.append(pdf_path, pages=pypdf.pagerange.PageRange(slice(0, 0))) merger.append(pdf_forms) merger.merge(0, pdf_path, import_outline=False) with pytest.raises(NotImplementedError) as exc: with open(pdf_path, "rb") as fp: data = fp.read() merger.append(data) assert exc.value.args[0].startswith( "Merging requires an object that PdfReader can parse. " "Typically, that is a Path" ) # Merging an encrypted file reader = pypdf.PdfReader(pdf_pw) reader.decrypt("openpassword") merger.append(reader) # PdfReader object: r = pypdf.PdfReader(pdf_path) merger.append(r, outline_item="foo", pages=list(range(len(r.pages)))) # File handle with open(pdf_path, "rb") as fh: merger.append(fh) # to force to build outlines and ensure the add_outline_item is # at end of the list merger.write(BytesIO()) outline_item = merger.add_outline_item("An outline item", 0) oi2 = merger.add_outline_item( "deeper", 0, parent=outline_item, italic=True, bold=True ) merger.add_outline_item( "Let's see", 2, oi2, (255, 255, 0), True, True, Fit.fit_box_vertically(left=12) ) merger.add_outline_item( "The XYZ fit", 0, outline_item, (255, 0, 15), True, True, Fit.xyz(left=10, top=20, zoom=3), ) merger.add_outline_item( "The FitH fit", 0, outline_item, (255, 0, 15), True, True, Fit.fit_horizontally(top=10), ) merger.add_outline_item( "The FitV fit", 0, outline_item, (255, 0, 15), True, True, Fit.fit_vertically(left=10), ) merger.add_outline_item( "The FitR fit", 0, outline_item, (255, 0, 15), True, True, Fit.fit_rectangle(left=10, bottom=20, right=30, top=40), ) merger.add_outline_item( "The FitB fit", 0, outline_item, (255, 0, 15), True, True, Fit.fit_box() ) merger.add_outline_item( "The FitBH fit", 0, outline_item, (255, 0, 15), True, True, Fit.fit_box_horizontally(top=10), ) merger.add_outline_item( "The FitBV fit", 0, outline_item, (255, 0, 15), True, True, Fit.fit_box_vertically(left=10), ) found_oi = merger.find_outline_item("nothing here") assert found_oi is None found_oi = merger.find_outline_item("foo") assert found_oi == [9] merger.add_metadata({"/Author": "Martin Thoma"}) merger.add_named_destination("/Title", 0) merger.set_page_layout("/SinglePage") merger.page_mode = "/UseThumbs" def check_outline(tmp_path): # Check if outline is correct reader = pypdf.PdfReader(tmp_path) assert [el.title for el in reader.outline if isinstance(el, Destination)] == [ "Foo", "Bar", "Baz", "Foo", "Bar", "Baz", "Foo", "Bar", "Baz", "foo", "An outline item", # this has been moved to end normal??? ] # TODO: There seem to be no destinations for those links? tmp_filename = "dont_commit_merged.pdf" def test_merger_operations_by_traditional_usage_with_writer(tmp_path): # Arrange merger = PdfWriter() merger_operate(merger) path = tmp_path / tmp_filename # Act merger.write(path) merger.close() # Assert check_outline(path) def test_merger_operations_by_semi_traditional_usage_with_writer(tmp_path): path = tmp_path / tmp_filename with PdfWriter() as merger: merger_operate(merger) merger.write(path) # Act # Assert assert Path(path).is_file() check_outline(path) def test_merger_operation_by_new_usage_with_writer(tmp_path): path = tmp_path / tmp_filename with PdfWriter(fileobj=path) as merger: merger_operate(merger) # Assert assert Path(path).is_file() check_outline(path) def test_merge_page_exception_with_writer(): merger = pypdf.PdfWriter() pdf_path = RESOURCE_ROOT / "crazyones.pdf" with pytest.raises(TypeError) as exc: merger.merge(0, pdf_path, pages="a:b") assert ( exc.value.args[0] == '"pages" must be a tuple of (start, stop[, step]) or a list' ) merger.close() def test_merge_page_tuple_with_writer(): merger = pypdf.PdfWriter() pdf_path = RESOURCE_ROOT / "crazyones.pdf" merger.merge(0, pdf_path, pages=(0, 1)) merger.close() def test_merge_write_closed_fh_with_writer(pdf_file_path): merger = pypdf.PdfWriter() pdf_path = RESOURCE_ROOT / "crazyones.pdf" merger.append(pdf_path) merger.close() merger.write(pdf_file_path) merger.add_metadata({"author": "Martin Thoma"}) merger.set_page_layout("/SinglePage") merger.page_mode = "/UseNone" merger.add_outline_item("An outline item", 0) @pytest.mark.enable_socket def test_trim_outline_list_with_writer(pdf_file_path): url = "https://github.com/user-attachments/files/18381771/tika-995175.pdf" name = "tika-995175.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) merger = PdfWriter() merger.append(reader) merger.add_outline_item_dict(merger.outline[0]) merger.write(pdf_file_path) merger.close() @pytest.mark.enable_socket def test_zoom_with_writer(pdf_file_path): url = "https://github.com/user-attachments/files/18381769/tika-994759.pdf" name = "tika-994759.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) merger = PdfWriter() merger.append(reader) merger.write(pdf_file_path) merger.close() @pytest.mark.enable_socket @pytest.mark.filterwarnings("ignore::DeprecationWarning") def test_zoom_xyz_no_left_with_add_page(pdf_file_path): url = "https://github.com/user-attachments/files/18381704/tika-933322.pdf" name = "tika-933322.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) merger = PdfWriter() for p in reader.pages: merger.add_page(p) merger.write(pdf_file_path) merger.close() @pytest.mark.enable_socket def test_zoom_xyz_no_left_with_writer(pdf_file_path): url = "https://github.com/user-attachments/files/18381704/tika-933322.pdf" name = "tika-933322.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) merger = PdfWriter() merger.append(reader) merger.write(pdf_file_path) merger.close() @pytest.mark.enable_socket @pytest.mark.slow def test_outline_item_with_writer(pdf_file_path): url = "https://github.com/user-attachments/files/18381773/tika-997511.pdf" name = "tika-997511.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) merger = PdfWriter() merger.append(reader) merger.write(pdf_file_path) merger.close() @pytest.mark.enable_socket @pytest.mark.slow def test_trim_outline_with_writer(pdf_file_path): url = "https://github.com/user-attachments/files/18381759/tika-982336.pdf" name = "tika-982336.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) merger = PdfWriter() merger.append(reader) merger.write(pdf_file_path) merger.close() @pytest.mark.enable_socket @pytest.mark.slow def test1_with_writer(pdf_file_path): url = "https://github.com/user-attachments/files/18381696/tika-923621.pdf" name = "tika-923621.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) merger = PdfWriter() merger.append(reader) merger.write(pdf_file_path) merger.close() @pytest.mark.enable_socket @pytest.mark.slow def test_sweep_recursion1_with_writer(pdf_file_path): # TODO: This test looks like an infinite loop. url = "https://github.com/user-attachments/files/18381697/tika-924546.pdf" name = "tika-924546.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) merger = PdfWriter() merger.append(reader) merger.write(pdf_file_path) merger.close() reader2 = PdfReader(pdf_file_path) reader2.pages @pytest.mark.enable_socket @pytest.mark.slow @pytest.mark.parametrize( ("url", "name"), [ ( # TODO: This test looks like an infinite loop. "https://github.com/user-attachments/files/18381700/tika-924794.pdf", "tika-924794.pdf", ), ( "https://github.com/user-attachments/files/18381697/tika-924546.pdf", "tika-924546.pdf", ), ], ) def test_sweep_recursion2_with_writer(url, name, pdf_file_path): reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) merger = PdfWriter() merger.append(reader) merger.write(pdf_file_path) merger.close() reader2 = PdfReader(pdf_file_path) reader2.pages @pytest.mark.enable_socket def test_sweep_indirect_list_newobj_is_none_with_writer(caplog, pdf_file_path): url = "https://github.com/user-attachments/files/18381681/tika-906769.pdf" name = "tika-906769.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) merger = PdfWriter() merger.append(reader) merger.write(pdf_file_path) merger.close() # used to be: assert "Object 21 0 not defined." in caplog.text reader2 = PdfReader(pdf_file_path) reader2.pages @pytest.mark.enable_socket def test_iss1145_with_writer(): # issue with FitH destination with null param url = "https://github.com/py-pdf/pypdf/files/9164743/file-0.pdf" name = "iss1145.pdf" merger = PdfWriter() merger.append(PdfReader(BytesIO(get_data_from_url(url, name=name)))) merger.close() @pytest.mark.enable_socket def test_iss1344_with_writer(caplog): url = "https://github.com/py-pdf/pypdf/files/9549001/input.pdf" name = "iss1344.pdf" m = PdfWriter() m.append(PdfReader(BytesIO(get_data_from_url(url, name=name)))) b = BytesIO() m.write(b) p = PdfReader(b).pages[0] assert "/DIJMAC+Arial Black" in p._debug_for_extract() assert "adresse oĂą le malade peut ĂŞtre visitĂ©" in p.extract_text() @pytest.mark.enable_socket def test_articles_with_writer(caplog): url = "https://github.com/user-attachments/files/18381699/tika-924666.pdf" name = "924666.pdf" m = PdfWriter() m.append(PdfReader(BytesIO(get_data_from_url(url, name=name))), (2, 10)) b = BytesIO() m.write(b) r = PdfReader(b) assert len(r.threads) == 4 assert r.threads[0].get_object()["/F"]["/P"] == r.pages[0] def test_get_reference(): writer = PdfWriter(RESOURCE_ROOT / "crazyones.pdf") assert writer.get_reference(writer.pages[0]) == writer.pages[0].indirect_reference @pytest.mark.enable_socket def test_direct_link_preserved(pdf_file_path): # this could be any PDF -- we don't care which reader = PdfReader(BytesIO(get_data_from_url(name="iss3268.pdf"))) writer = PdfWriter(clone_from=reader) # this PDF has a direct link from p1 to p2 merger = PdfReader(BytesIO(get_data_from_url(name="direct-link.pdf"))) for p in merger.pages: writer.add_page(p) writer.write(pdf_file_path) check = PdfReader(pdf_file_path) page3 = check.pages[2] link = page3["/Annots"][0].get_object() assert link["/Subtype"] == "/Link" dest = link["/Dest"][0] # indirect reference of page referred to page4 = check.flattened_pages[3] assert dest == page4.indirect_reference, "Link from page 3 to page 4 is broken" @pytest.mark.enable_socket def test_direct_link_preserved_reordering(pdf_file_path): # this could be any PDF -- we don't care which reader = PdfReader(BytesIO(get_data_from_url(name="iss3268.pdf"))) writer = PdfWriter(clone_from=reader) # this PDF has a direct link from p1 to p2 merger = PdfReader(BytesIO(get_data_from_url(name="direct-link.pdf"))) for p in merger.pages: writer.add_page(p) # let's insert a page to mess up the page order writer.insert_page(reader.pages[0], 3) writer.write(pdf_file_path) check = PdfReader(pdf_file_path) page3 = check.pages[2] link = page3["/Annots"][0].get_object() assert link["/Subtype"] == "/Link" dest = link["/Dest"][0] # indirect reference of page referred to page5 = check.flattened_pages[4] # it moved one out assert dest == page5.indirect_reference, "Link from page 3 to page 5 is broken" @pytest.mark.enable_socket def test_direct_link_page_missing(pdf_file_path): # this could be any PDF -- we don't care which reader = PdfReader(BytesIO(get_data_from_url(name="iss3268.pdf"))) writer = PdfWriter(clone_from=reader) # this PDF has a direct link from p1 to p2 merger = PdfReader(BytesIO(get_data_from_url(name="direct-link.pdf"))) writer.add_page(merger.pages[0]) # but we're not adding page 2 writer.write(pdf_file_path) # verify nothing crashes @pytest.mark.enable_socket def test_named_reference_preserved(pdf_file_path): # this could be any PDF -- we don't care which reader = PdfReader(BytesIO(get_data_from_url(name="iss3268.pdf"))) writer = PdfWriter(clone_from=reader) # this PDF has a named reference from from p3 to p5 merger = PdfReader(BytesIO(get_data_from_url(name="named-reference.pdf"))) for p in merger.pages: writer.add_page(p) writer.write(pdf_file_path) check = PdfReader(pdf_file_path) page5 = check.pages[4] page7 = check.flattened_pages[6] for link in page5["/Annots"]: action = link["/A"] assert action.get("/S") == "/GoTo" dest = str(action["/D"]) assert dest in check.named_destinations pref = check.named_destinations[dest].page assert pref == page7.indirect_reference, "Link from page 5 to page 7 is broken" @pytest.mark.enable_socket def test_named_ref_to_page_that_is_gone(pdf_file_path): source = PdfReader(BytesIO(get_data_from_url(name="named-reference.pdf"))) buf = BytesIO() tmp = PdfWriter() tmp.add_page(source.pages[2]) # we add only the page with the reference tmp.write(buf) source = PdfReader(buf) writer = PdfWriter() writer.add_page(source.pages[0]) # now references to non-existent page writer.write(pdf_file_path) # don't crash pypdf-6.1.2/tests/test_page.py000066400000000000000000001436031507516550200163460ustar00rootroot00000000000000"""Test the pypdf._page module.""" import json import logging import math from copy import deepcopy from io import BytesIO from pathlib import Path from random import shuffle from typing import Any from unittest import mock import pytest from pypdf import PdfReader, PdfWriter, Transformation from pypdf._page import PageObject from pypdf.constants import PageAttributes as PG from pypdf.errors import PdfReadError, PdfReadWarning, PyPdfError from pypdf.generic import ( ArrayObject, ContentStream, DictionaryObject, FloatObject, IndirectObject, NameObject, NullObject, RectangleObject, TextStringObject, ) from . import get_data_from_url, normalize_warnings TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" SAMPLE_ROOT = PROJECT_ROOT / "sample-files" def get_all_sample_files(): meta_file = SAMPLE_ROOT / "files.json" if not Path(meta_file).is_file(): return {"data": []} with open(meta_file) as fp: data = fp.read() return json.loads(data) all_files_meta = get_all_sample_files() @pytest.mark.samples @pytest.mark.parametrize( "meta", [m for m in all_files_meta["data"] if not m["encrypted"]], ids=[m["path"] for m in all_files_meta["data"] if not m["encrypted"]], ) @pytest.mark.filterwarnings("ignore::pypdf.errors.PdfReadWarning") def test_read(meta): pdf_path = SAMPLE_ROOT / meta["path"] reader = PdfReader(pdf_path) try: reader.pages[0] except Exception: return assert len(reader.pages) == meta["pages"] @pytest.mark.samples @pytest.mark.enable_socket @pytest.mark.parametrize( ("pdf_path", "password"), [ ("crazyones.pdf", None), ("attachment.pdf", None), ( "libreoffice-writer-password.pdf", "openpassword", ), ("imagemagick-images.pdf", None), ("imagemagick-lzw.pdf", None), ("reportlab-inline-image.pdf", None), ("https://arxiv.org/pdf/2201.00029.pdf", None), ], ) def test_page_operations(pdf_path, password): """ This test just checks if the operation throws an exception. This should be done way more thoroughly: It should be checked if the output is as expected. """ if pdf_path.startswith("http"): pdf_path = BytesIO(get_data_from_url(pdf_path, pdf_path.split("/")[-1])) else: pdf_path = RESOURCE_ROOT / pdf_path reader = PdfReader(pdf_path) writer = PdfWriter() if password: reader.decrypt(password) writer.clone_document_from_reader(reader) page: PageObject = writer.pages[0] t = Transformation().translate(50, 100).rotate(90) assert abs(t.ctm[4] + 100) < 0.01 assert abs(t.ctm[5] - 50) < 0.01 transformation = ( Transformation() .rotate(90) .scale(1) .translate(1, 1) .transform(Transformation((1, 0, 0, -1, 0, 0))) ) page.add_transformation(transformation, expand=True) page.add_transformation((1, 0, 0, 0, 0, 0)) page.scale(2, 2) page.scale_by(0.5) page.scale_to(100, 100) page.compress_content_streams() page.extract_text() page.scale_by(0.5) page.scale_to(100, 100) page.extract_text() @pytest.mark.parametrize( ("angle", "expected_width", "expected_height"), [ (175, 680, 844), (45, 994, 994), (-80, 888, 742), ], ) def test_mediabox_expansion_after_rotation( angle: float, expected_width: int, expected_height: int ): """ Mediabox dimensions after rotation at a non-right angle with expansion are correct. The test was validated against pillow (see PR #2282) """ pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) transformation = Transformation().rotate(angle) for page_box in reader.pages: page_box.add_transformation(transformation, expand=True) mediabox = reader.pages[0].mediabox # Deviation of up to 2 pixels is acceptable assert math.isclose(mediabox.width, expected_width, abs_tol=2) assert math.isclose(mediabox.height, expected_height, abs_tol=2) def test_transformation_equivalence(): pdf_path = RESOURCE_ROOT / "labeled-edges-center-image.pdf" reader_base = PdfReader(pdf_path) page_base = reader_base.pages[0] pdf_path = RESOURCE_ROOT / "box.pdf" reader_add = PdfReader(pdf_path) page_box = reader_add.pages[0] op = Transformation().scale(2).rotate(45) # Option 1: The new way page_box1 = deepcopy(page_box) page_base1 = deepcopy(page_base) page_box1.add_transformation(op, expand=True) page_base1.merge_page(page_box1, expand=False) # Option 2: The old way page_box2 = deepcopy(page_box) page_base2 = deepcopy(page_base) page_base2.merge_transformed_page(page_box2, op, expand=False) page_box2.add_transformation(op) page_base2.merge_page(page_box2) # Should be the same assert page_base1[NameObject(PG.CONTENTS)] == page_base2[NameObject(PG.CONTENTS)] assert page_base1.mediabox == page_base2.mediabox assert page_base1.trimbox == page_base2.trimbox assert page_base1[NameObject(PG.ANNOTS)] == page_base2[NameObject(PG.ANNOTS)] compare_dict_objects( page_base1[NameObject(PG.RESOURCES)], page_base2[NameObject(PG.RESOURCES)] ) def test_transformation_equivalence2(): pdf_path = RESOURCE_ROOT / "labeled-edges-center-image.pdf" reader_base = PdfReader(pdf_path) pdf_path = RESOURCE_ROOT / "box.pdf" reader_add = PdfReader(pdf_path) writer = PdfWriter() writer.append(reader_base) writer.pages[0].merge_transformed_page( reader_add.pages[0], Transformation().scale(2).rotate(-45), False, False ) writer.pages[0].merge_transformed_page( reader_add.pages[0], Transformation().scale(2).translate(100, 100), True, False ) # No special assert: the test should be visual in a viewer; 2 box with a arrow rotated and translated writer = PdfWriter() writer.append(reader_add) writer.pages[0].merge_transformed_page( reader_base.pages[0], Transformation(), True, True ) # No special assert: Visual check the page has been increased and all is visible (box+graph) writer = PdfWriter() writer.append(reader_add) height = reader_add.pages[0].mediabox.height writer.pages[0].merge_transformed_page( reader_base.pages[0], Transformation().transform(Transformation((1, 0, 0, -1, 0, height))), False, False, ) # No special assert: Visual check the page has been increased and all is visible (box+graph) pdf_path = RESOURCE_ROOT / "commented-xmp.pdf" reader_comments = PdfReader(pdf_path) writer = PdfWriter() writer.append(reader_base) writer.pages[0].merge_transformed_page( reader_comments.pages[0], Transformation().rotate(-15), True, True ) nb_annots1 = len(writer.pages[0]["/Annots"]) writer.pages[0].merge_transformed_page( reader_comments.pages[0], Transformation().rotate(-30), True, True ) assert len(writer.pages[0]["/Annots"]) == 2 * nb_annots1 # No special assert: Visual check the overlay has its comments at the good position def test_get_user_unit_property(): pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) assert reader.pages[0].user_unit == 1 def compare_dict_objects(d1, d2): assert sorted(d1.keys()) == sorted(d2.keys()) for key in d1: if isinstance(d1[key], DictionaryObject): compare_dict_objects(d1[key], d2[key]) else: assert d1[key] == d2[key] @pytest.mark.slow def test_page_transformations(): pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) page: PageObject = reader.pages[0] page.merge_rotated_page(page, 90, expand=True) op = Transformation().rotate(90).scale(1, 1) page.merge_transformed_page(page, op, expand=True) op = Transformation().rotate(90).scale(1, 1).translate(1, 1) page.merge_transformed_page(page, op, expand=True) op = Transformation().translate(-100, -100).rotate(90).translate(100, 100) page.merge_transformed_page(page, op, expand=False) page.merge_scaled_page(page, 2, expand=False) op = Transformation().scale(1, 1).translate(1, 1) page.merge_transformed_page(page, op) page.merge_translated_page(page, 100, 100, expand=False) page.add_transformation((1, 0, 0, 0, 0, 0)) @pytest.mark.parametrize( ("pdf_path", "password"), [ (RESOURCE_ROOT / "crazyones.pdf", None), (RESOURCE_ROOT / "attachment.pdf", None), (RESOURCE_ROOT / "side-by-side-subfig.pdf", None), ( RESOURCE_ROOT / "libreoffice-writer-password.pdf", "openpassword", ), ], ) def test_compress_content_streams(pdf_path, password): reader = PdfReader(pdf_path) writer = PdfWriter() if password: reader.decrypt(password) for i, page in enumerate(reader.pages): assert i == page.page_number assert isinstance(reader.pages[0].get_contents(), ContentStream) writer.clone_document_from_reader(reader) assert isinstance(writer.pages[0].get_contents(), ContentStream) for i, page in enumerate(writer.pages): assert i == page.page_number page.compress_content_streams() # test from reader should fail as adding_object out of # PdfWriter not possible with pytest.raises(ValueError): reader.pages[0].compress_content_streams() def test_page_properties(): reader = PdfReader(RESOURCE_ROOT / "crazyones.pdf") page = reader.pages[0] assert page.mediabox == RectangleObject((0, 0, 612, 792)) assert page.cropbox == RectangleObject((0, 0, 612, 792)) assert page.bleedbox == RectangleObject((0, 0, 612, 792)) assert page.trimbox == RectangleObject((0, 0, 612, 792)) assert page.artbox == RectangleObject((0, 0, 612, 792)) page.bleedbox = RectangleObject((0, 1, 100, 101)) assert page.bleedbox == RectangleObject((0, 1, 100, 101)) def test_page_rotation(): reader = PdfReader(RESOURCE_ROOT / "crazyones.pdf") page = reader.pages[0] with pytest.raises(ValueError) as exc: page.rotate(91) assert exc.value.args[0] == "Rotation angle must be a multiple of 90" # test rotation assert page.rotation == 0 page.rotation = 180 assert page.rotation == 180 page.rotation += 190 assert page.rotation == 0 # test transfer_rotate_to_content page.rotation -= 90 page.transfer_rotation_to_content() assert math.isclose(page.mediabox.left, 0, abs_tol=0.1) assert math.isclose(page.mediabox.bottom, 0, abs_tol=0.1) assert math.isclose(page.mediabox.right, 792, abs_tol=0.1) assert math.isclose(page.mediabox.top, 612, abs_tol=0.1) def test_page_indirect_rotation(): reader = PdfReader(RESOURCE_ROOT / "indirect-rotation.pdf") page = reader.pages[0] # test rotation assert page.rotation == 0 def test_page_scale(): op = Transformation() with pytest.raises(ValueError) as exc: op.scale() assert exc.value.args[0] == "Either sx or sy must be specified" assert op.scale(sx=2).ctm == (2, 0, 0, 2, 0, 0) assert op.scale(sy=3).ctm == (3, 0, 0, 3, 0, 0) def test_add_transformation_on_page_without_contents(): page = PageObject() assert page.get_contents() is None page.add_transformation(Transformation()) page[NameObject("/Contents")] = ContentStream(None, None) assert isinstance(page.get_contents(), ContentStream) @pytest.mark.enable_socket def test_iss_1142(): # check fix for problem of context save/restore (q/Q) url = "https://github.com/py-pdf/pypdf/files/9150656/ST.2019.PDF" name = "st2019.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) txt = reader.pages[3].extract_text() # The following text is contained in two different cells: assert txt.find("有é™ĺ…¬ĺŹ¸") > 0 assert txt.find("é‘ĺ·žĺ†ĺ…¬ĺŹ¸") > 0 # 有é™ĺ…¬ĺŹ¸ = limited company # é‘ĺ·žĺ†ĺ…¬ĺŹ¸ = branch office in Zhengzhou # First cell (see page 4/254): assert txt.find("é‘州药素电ĺ­ĺ•†ĺŠˇćś‰é™ĺ…¬ĺŹ¸") > 0 # Next cell (first cell in next line): assert txt.find("é‘ĺ·žĺ†ĺ…¬ĺŹ¸") > 0 @pytest.mark.enable_socket @pytest.mark.slow @pytest.mark.parametrize( ("url", "name"), [ # keyerror_potentially_empty_page ( "https://github.com/user-attachments/files/18381736/tika-964029.pdf", "tika-964029.pdf", ), # 1140 / 1141: ( "https://github.com/user-attachments/files/18381702/tika-932446.pdf", "tika-932446.pdf", ), # iss 1134: ( "https://github.com/py-pdf/pypdf/files/9150656/ST.2019.PDF", "iss_1134.pdf", ), # iss 1: ( "https://github.com/py-pdf/pypdf/files/9432350/Work.Flow.From.Check.to.QA.pdf", "WFCA.pdf", ), ( "https://github.com/user-attachments/files/18381736/tika-964029.pdf", "tika-964029.pdf", ), # single_quote_op ( "https://github.com/py-pdf/pypdf/files/9428434/TelemetryTX_EM.pdf", "tika-964029.pdf", ), # no_ressources ( # https://www.itu.int/rec/T-REC-X.25-199610-I/en "https://github.com/py-pdf/pypdf/files/12423313/T-REC-X.25-199610-I.PDF-E.pdf", "T-REC-X.25-199610-I!!PDF-E.pdf", ), ], ) def test_extract_text(url, name): reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) for page in reader.pages: page.extract_text() @pytest.mark.enable_socket @pytest.mark.slow def test_extract_text_page_pdf_impossible_decode_xform(caplog): url = "https://github.com/user-attachments/files/18381748/tika-972962.pdf" name = "tika-972962.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) for page in reader.pages: page.extract_text() warn_msgs = normalize_warnings(caplog.text) assert warn_msgs == [""] # text extraction recognise no text @pytest.mark.enable_socket @pytest.mark.slow def test_extract_text_operator_t_star(): # L1266, L1267 url = "https://github.com/user-attachments/files/18381740/tika-967943.pdf" name = "tika-967943.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) for page in reader.pages: page.extract_text() def test_extract_text_visitor_callbacks(): """ Extract text in rectangle-objects or simple tables. This test uses GeoBase_NHNC1_Data_Model_UML_EN.pdf. It extracts the labels of package-boxes in Figure 2. It extracts the texts in table "REVISION HISTORY". """ class PositionedText: """ Specify a text with coordinates, font-dictionary and font-size. The font-dictionary may be None in case of an unknown font. """ def __init__(self, text, x, y, font_dict, font_size) -> None: # TODO: \0-replace: Encoding issue in some files? self.text = text.replace("\0", "") self.x = x self.y = y self.font_dict = font_dict self.font_size = font_size def get_base_font(self) -> str: """ Gets the base font of the text. Return UNKNOWN in case of an unknown font. """ if (self.font_dict is None) or "/BaseFont" not in self.font_dict: return "UNKNOWN" return self.font_dict["/BaseFont"] class Rectangle: """Specify a rectangle.""" def __init__(self, x, y, w, h) -> None: self.x = x.as_numeric() self.y = y.as_numeric() self.w = w.as_numeric() self.h = h.as_numeric() def contains(self, x, y) -> bool: return ( self.x <= x <= (self.x + self.w) and self.y <= y <= (self.y + self.h) ) def extract_text_and_rectangles( page: PageObject, rect_filter=None ) -> tuple[list[PositionedText], list[Rectangle]]: """ Extracts texts and rectangles of a page of type pypdf._page.PageObject. This function supports simple coordinate transformations only. The optional rect_filter-lambda can be used to filter wanted rectangles. rect_filter has Rectangle as argument and must return a boolean. It returns a tuple containing a list of extracted texts and a list of extracted rectangles. """ logger = logging.getLogger("extract_text_and_rectangles") rectangles = [] texts = [] def print_op_b(op, args, cm_matrix, tm_matrix) -> None: if logger.isEnabledFor(logging.DEBUG): logger.debug(f"before: {op} at {cm_matrix}, {tm_matrix}") if op == b"re": if logger.isEnabledFor(logging.DEBUG): logger.debug(f" add rectangle: {args}") w = args[2] h = args[3] r = Rectangle(args[0], args[1], w, h) if (rect_filter is None) or rect_filter(r): rectangles.append(r) def print_visi(text, cm_matrix, tm_matrix, font_dict, font_size) -> None: if text.strip() != "": if logger.isEnabledFor(logging.DEBUG): logger.debug(f"at {cm_matrix}, {tm_matrix}, font size={font_size}") texts.append( PositionedText( text, tm_matrix[4], tm_matrix[5], font_dict, font_size ) ) visitor_before = print_op_b visitor_text = print_visi page.extract_text( visitor_operand_before=visitor_before, visitor_text=visitor_text ) return (texts, rectangles) def extract_table( texts: list[PositionedText], rectangles: list[Rectangle] ) -> list[list[list[PositionedText]]]: """ Extracts a table containing text. It is expected that each cell is marked by a rectangle-object. It is expected that the page contains one table only. It is expected that the table contains at least 3 columns and 2 rows. A list of rows is returned. Each row contains a list of cells. Each cell contains a list of PositionedText-elements. """ logger = logging.getLogger("extractTable") # Step 1: Count number of x- and y-coordinates of rectangles. # Remove duplicate rectangles. The new list is rectangles_filtered. col2count = {} row2count = {} key2rectangle = {} rectangles_filtered = [] for r in rectangles: # Coordinates may be inaccurate, we have to round. # cell: x=72.264, y=386.57, w=93.96, h=46.584 # cell: x=72.271, y=386.56, w=93.96, h=46.59 key = f"{round(r.x, 0)} {round(r.y, 0)} {round(r.w, 0)} {round(r.h, 0)}" if key in key2rectangle: # Ignore duplicate rectangles continue key2rectangle[key] = r if r.x not in col2count: col2count[r.x] = 0 if r.y not in row2count: row2count[r.y] = 0 col2count[r.x] += 1 row2count[r.y] += 1 rectangles_filtered.append(r) # Step 2: Look for texts in rectangles. rectangle2texts = {} for text in texts: for r in rectangles_filtered: if r.contains(text.x, text.y): if r not in rectangle2texts: rectangle2texts[r] = [] rectangle2texts[r].append(text) break # PDF: y = 0 is expected at the bottom of the page. # So the header-row is expected to have the highest y-value. rectangles.sort(key=lambda r: (-r.y, r.x)) # Step 3: Build the list of rows containing list of cell-texts. rows = [] row_nr = 0 col_nr = 0 curr_y = None curr_row = None for r in rectangles_filtered: if col2count[r.x] < 3 or row2count[r.y] < 2: # We expect at least 3 columns and 2 rows. continue if curr_y is None or r.y != curr_y: # next row curr_y = r.y col_nr = 0 row_nr += 1 curr_row = [] rows.append(curr_row) col_nr += 1 if logger.isEnabledFor(logging.DEBUG): logger.debug(f"cell: x={r.x}, y={r.y}, w={r.w}, h={r.h}") if r not in rectangle2texts: curr_row.append("") continue cell_texts = list(rectangle2texts[r]) curr_row.append(cell_texts) return rows def extract_cell_text(cell_texts: list[PositionedText]) -> str: """Joins the text-objects of a cell.""" return ("".join(t.text for t in cell_texts)).strip() # Test 1: We test the analysis of page 7 "2.1 LRS model". reader = PdfReader(RESOURCE_ROOT / "GeoBase_NHNC1_Data_Model_UML_EN.pdf") page_lrs_model = reader.pages[6] # We ignore the invisible large rectangles. def ignore_large_rectangles(r) -> bool: return r.w < 400 and r.h < 400 (texts, rectangles) = extract_text_and_rectangles( page_lrs_model, rect_filter=ignore_large_rectangles ) # We see ten rectangles (5 tabs, 5 boxes) but there are 64 rectangles # (including some invisible ones). assert len(rectangles) == 60 rectangle2texts = {} for t in texts: for r in rectangles: if r.contains(t.x, t.y): texts = rectangle2texts.setdefault(r, []) texts.append(t.text.strip()) break # Five boxes and the figure-description below. assert len(rectangle2texts) == 6 box_texts = [" ".join(texts) for texts in rectangle2texts.values()] assert "Hydro Network" in box_texts assert "Hydro Events" in box_texts assert "Metadata" in box_texts assert "Hydrography" in box_texts assert "Toponymy (external model)" in box_texts # Test 2: Parse table "REVISION HISTORY" on page 3. page_revisions = reader.pages[2] # We ignore the second table, therefore: r.y > 350 def filter_first_table(r) -> bool: return r.w > 1 and r.h > 1 and r.w < 400 and r.h < 400 and r.y > 350 (texts, rectangles) = extract_text_and_rectangles( page_revisions, rect_filter=filter_first_table ) rows = extract_table(texts, rectangles) assert len(rows) == 9 assert extract_cell_text(rows[0][0]) == "Date" assert extract_cell_text(rows[0][1]) == "Version" assert extract_cell_text(rows[0][2]) == "Description" assert extract_cell_text(rows[1][0]) == "September 2002" # The line break between "English review;" # and "Remove" is not detected. assert ( extract_cell_text(rows[6][2]) == "English review;Remove the UML model for the Segmented view." ) assert extract_cell_text(rows[7][2]) == "Update from the March Workshop comments." # Check the fonts. We check: /F2 9.96 Tf [...] [(Dat)-2(e)] TJ text_dat_of_date = rows[0][0][0] assert text_dat_of_date.font_dict is not None assert text_dat_of_date.font_dict["/Name"] == "/F2" assert text_dat_of_date.get_base_font() == "/Arial,Bold" assert text_dat_of_date.font_dict["/Encoding"] == "/WinAnsiEncoding" assert text_dat_of_date.font_size == 9.96 # Check: /F1 9.96 Tf [...] [(S)4(ep)4(t)-10(em)-20(be)4(r)-3( 20)4(02)] TJ texts = rows[1][0][0] assert texts.font_dict is not None assert texts.font_dict["/Name"] == "/F1" assert texts.get_base_font() == "/Arial" assert texts.font_dict["/Encoding"] == "/WinAnsiEncoding" assert text_dat_of_date.font_size == 9.96 # Test 3: Read a table in a document using a non-translating # but scaling Tm-operand reader = PdfReader(RESOURCE_ROOT / "Sample_Td-matrix.pdf") page_td_model = reader.pages[0] # We store the translations of the Td-executions. list_td = [] def visitor_td(op, args, cm, tm) -> None: if op == b"Td": list_td.append((tm[4], tm[5])) page_td_model.extract_text(visitor_operand_after=visitor_td) assert len(list_td) == 4 # Check the translations of the four Td-executions. assert list_td[0] == (210.0, 110.0) assert list_td[1] == (410.0, 110.0) assert list_td[2] == (210.0, 210.0) assert list_td[3] == (410.0, 210.0) @pytest.mark.parametrize( ("pdf_path", "password", "embedded", "unembedded"), [ ( RESOURCE_ROOT / "crazyones.pdf", None, { "/HHXGQB+SFTI1440", "/TITXYI+SFRM0900", "/YISQAD+SFTI1200", }, set(), ), ( RESOURCE_ROOT / "attachment.pdf", None, { "/HHXGQB+SFTI1440", "/TITXYI+SFRM0900", "/YISQAD+SFTI1200", }, set(), ), ( RESOURCE_ROOT / "libreoffice-writer-password.pdf", "openpassword", {"/BAAAAA+DejaVuSans"}, set(), ), ( RESOURCE_ROOT / "imagemagick-images.pdf", None, set(), {"/Helvetica"}, ), (RESOURCE_ROOT / "imagemagick-lzw.pdf", None, set(), set()), ( RESOURCE_ROOT / "reportlab-inline-image.pdf", None, set(), {"/Helvetica"}, ), # fonts in annotations ( RESOURCE_ROOT / "FormTestFromOo.pdf", None, {"/CAAAAA+LiberationSans", "/EAAAAA+SegoeUI", "/BAAAAA+LiberationSerif"}, {"/LiberationSans", "/ZapfDingbats"}, ), ], ) def test_get_fonts(pdf_path, password, embedded, unembedded): reader = PdfReader(pdf_path, password=password) a = set() b = set() for page in reader.pages: a_tmp, b_tmp = page._get_fonts() a = a.union(a_tmp) b = b.union(b_tmp) assert (a, b) == (embedded, unembedded) @pytest.mark.enable_socket def test_get_fonts2(): url = "https://github.com/py-pdf/pypdf/files/12618104/WS_T.483.8-2016.pdf" name = "WS_T.483.8-2016.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert reader.pages[1]._get_fonts() == ( { "/E-HZ9-PK7483a5-Identity-H", "/SSJ-PK748200005d9-Identity-H", "/QGNGZS+FzBookMaker1DlFont10536872415", "/E-BZ9-PK748344-Identity-H", "/E-FZ9-PK74836f-Identity-H", "/O9-PK748464-Identity-H", "/QGNGZR+FzBookMaker0DlFont00536872414", "/SSJ-PK748200005db-Identity-H", "/F-BZ9-PK7483cb-Identity-H", "/SSJ-PK748200005da-Identity-H", "/H-SS9-PK748200005e0-Identity-H", "/H-HT9-PK748200005e1-Identity-H", }, set(), ) assert reader.pages[2]._get_fonts() == ( { "/E-HZ9-PK7483a5-Identity-H", "/E-FZ9-PK74836f-Identity-H", "/E-BZ9-PK748344-Identity-H", "/QGNGZT+FzBookMaker0DlFont00536872418", "/O9-PK748464-Identity-H", "/F-BZ9-PK7483cb-Identity-H", "/H-SS9-PK748200005e0-Identity-H", "/QGNGZU+FzBookMaker1DlFont10536872420", "/H-HT9-PK748200005e1-Identity-H", }, set(), ) def test_annotation_getter(): pdf_path = RESOURCE_ROOT / "commented.pdf" reader = PdfReader(pdf_path) annotations = reader.pages[0].annotations assert annotations is not None assert isinstance(annotations[0], IndirectObject) annot_dict = dict(annotations[0].get_object()) assert "/P" in annot_dict assert isinstance(annot_dict["/P"], IndirectObject) del annot_dict["/P"] annot_dict["/Popup"] = annot_dict["/Popup"].get_object() del annot_dict["/Popup"]["/P"] del annot_dict["/Popup"]["/Parent"] assert annot_dict == { "/Type": "/Annot", "/Subtype": "/Text", "/Rect": ArrayObject( [ 270.75, 596.25, 294.75, 620.25, ] ), "/Contents": "Note in second paragraph", "/C": ArrayObject([1, 1, 0]), "/M": "D:20220406191858+02'00", "/Popup": DictionaryObject( { "/M": "D:20220406191847+02'00", "/Rect": ArrayObject([294.75, 446.25, 494.75, 596.25]), "/Subtype": "/Popup", "/Type": "/Annot", } ), "/T": "moose", } def test_annotation_setter(pdf_file_path): # Arange pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) with pytest.raises(ValueError): writer.add_page(DictionaryObject()) # Act page_number = 0 page_link = writer.get_object(writer._pages)["/Kids"][page_number] annot_dict = { NameObject("/P"): page_link, NameObject("/Type"): NameObject("/Annot"), NameObject("/Subtype"): NameObject("/Text"), NameObject("/Rect"): ArrayObject( [ FloatObject(270.75), FloatObject(596.25), FloatObject(294.75), FloatObject(620.25), ] ), NameObject("/Contents"): TextStringObject("Note in second paragraph"), NameObject("/C"): ArrayObject([FloatObject(1), FloatObject(1), FloatObject(0)]), NameObject("/M"): TextStringObject("D:20220406191858+02'00"), NameObject("/Popup"): DictionaryObject( { NameObject("/M"): TextStringObject("D:20220406191847+02'00"), NameObject("/Rect"): ArrayObject( [ FloatObject(294.75), FloatObject(446.25), FloatObject(494.75), FloatObject(596.25), ] ), NameObject("/Subtype"): NameObject("/Popup"), NameObject("/Type"): TextStringObject("/Annot"), } ), NameObject("/T"): TextStringObject("moose"), } arr = ArrayObject() page.annotations = arr # Delete Annotations page.annotations = None d = DictionaryObject(annot_dict) ind_obj = writer._add_object(d) arr.append(ind_obj) # Assert manually with open(pdf_file_path, "wb") as fp: writer.write(fp) @pytest.mark.enable_socket @pytest.mark.xfail(reason="#1091") def test_text_extraction_issue_1091(): url = "https://github.com/user-attachments/files/18381737/tika-966635.pdf" name = "tika-966635.pdf" stream = BytesIO(get_data_from_url(url, name=name)) with pytest.warns(PdfReadWarning): reader = PdfReader(stream) for page in reader.pages: page.extract_text() @pytest.mark.enable_socket def test_empyt_password_1088(): url = "https://github.com/user-attachments/files/18381712/tika-941536.pdf" name = "tika-941536.pdf" stream = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(stream) len(reader.pages) @pytest.mark.enable_socket def test_old_habibi(): # this habibi has multiple characters associated with the h reader = PdfReader(SAMPLE_ROOT / "015-arabic/habibi.pdf") txt = reader.pages[0].extract_text() # very odd file # extract from acrobat reader "حَبيبي habibiô€€ô€Ź˛ô€Ž’ô€Ź´ô€Ž’ô€ŽŁô€‹´ assert "habibi" in txt assert "حَبيبي" in txt @pytest.mark.samples def test_read_link_annotation(): reader = PdfReader(SAMPLE_ROOT / "016-libre-office-link/libre-office-link.pdf") assert len(reader.pages[0].annotations) == 1 annot = dict(reader.pages[0].annotations[0].get_object()) expected = { "/Type": "/Annot", "/Subtype": "/Link", "/A": DictionaryObject( { "/S": "/URI", "/Type": "/Action", "/URI": "https://martin-thoma.com/", } ), "/Border": ArrayObject([0, 0, 0]), "/Rect": [ 92.043, 771.389, 217.757, 785.189, ], } assert set(expected.keys()) == set(annot.keys()) del expected["/Rect"] del annot["/Rect"] assert annot == expected @pytest.mark.enable_socket def test_no_resources(): url = "https://github.com/py-pdf/pypdf/files/9572045/108.pdf" name = "108.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) page_one = reader.pages[0] page_two = reader.pages[0] page_one.merge_page(page_two) def test_merge_page_reproducible_with_proc_set(): page1 = PageObject.create_blank_page(width=100, height=100) page2 = PageObject.create_blank_page(width=100, height=100) ordered = sorted(NameObject(f"/{x}") for x in range(20)) shuffled = list(ordered) shuffle(shuffled) # each page has some overlap in their /ProcSet, and they're in a weird order page1[NameObject("/Resources")][NameObject("/ProcSet")] = ArrayObject(shuffled[:15]) page2[NameObject("/Resources")][NameObject("/ProcSet")] = ArrayObject(shuffled[5:]) page1.merge_page(page2) assert page1[NameObject("/Resources")][NameObject("/ProcSet")] == ordered @pytest.mark.parametrize( ("apage1", "apage2", "expected_result", "expected_renames"), [ # simple cases: pytest.param({}, {}, {}, {}, id="no resources"), pytest.param( {"/1": "/v1"}, {"/2": "/v2"}, {"/1": "/v1", "/2": "/v2"}, {}, id="no overlap", ), pytest.param( {"/x": "/v"}, {"/x": "/v"}, {"/x": "/v"}, {}, id="overlap, matching values" ), pytest.param( {"/x": "/v1"}, {"/x": "/v2"}, {"/x": "/v1", "/x-0": "/v2"}, {"/x": "/x-0"}, id="overlap, different values", ), # carefully crafted names that match the renaming pattern: pytest.param( {"/x": "/v1", "/x-0": "/v1", "/x-1": "/v1"}, {"/x": "/v2"}, { "/x": "/v1", "/x-0": "/v1", "/x-1": "/v1", "/x-2": "/v2", }, {"/x": "/x-2"}, id="crafted, different values", ), pytest.param( {"/x": "/v1", "/x-0": "/v1", "/x-1": "/v"}, {"/x": "/v"}, {"/x": "/v1", "/x-0": "/v1", "/x-1": "/v"}, {"/x": "/x-1"}, id="crafted, matching value in chain", ), pytest.param( {"/x": "/v1"}, {"/x": "/v2.1", "/x-0": "/v2.2"}, {"/x": "/v1", "/x-0": "/v2.1", "/x-0-0": "/v2.2"}, {"/x": "/x-0", "/x-0": "/x-0-0"}, id="crafted, overlaps with previous rename, different value", ), pytest.param( {"/x": "/v1"}, {"/x": "/v2", "/x-0": "/v2"}, {"/x": "/v1", "/x-0": "/v2"}, {"/x": "/x-0"}, id="crafted, overlaps with previous rename, matching value", ), ], ) def test_merge_resources(apage1, apage2, expected_result, expected_renames): for new_res in (False, True): # Arrange page1 = PageObject() page1[NameObject(PG.RESOURCES)] = DictionaryObject() for k, v in apage1.items(): page1[PG.RESOURCES][NameObject(k)] = NameObject(v) page2 = PageObject() page2[NameObject(PG.RESOURCES)] = DictionaryObject() for k, v in apage2.items(): page2[PG.RESOURCES][NameObject(k)] = NameObject(v) # Act result, renames = page1._merge_resources(page1, page2, PG.RESOURCES, new_res) # Assert assert result == expected_result assert renames == expected_renames def test_merge_page_resources_smoke_test(): # Arrange page1 = PageObject.create_blank_page(width=100, height=100) page2 = PageObject.create_blank_page(width=100, height=100) NO = NameObject # set up some dummy resources that overlap (or not) between the two pages # (note, all the edge cases are tested in test_merge_resources) props1 = page1[NO("/Resources")][NO("/Properties")] = DictionaryObject( { NO("/just1"): NO("/just1-value"), NO("/overlap-matching"): NO("/overlap-matching-value"), NO("/overlap-different"): NO("/overlap-different-value1"), } ) props2 = page2[NO("/Resources")][NO("/Properties")] = DictionaryObject( { NO("/just2"): NO("/just2-value"), NO("/overlap-matching"): NO("/overlap-matching-value"), NO("/overlap-different"): NO("/overlap-different-value2"), } ) # use these keys for some "operations", to validate renaming # (the operand name doesn't matter) contents1 = page1[NO("/Contents")] = ContentStream(None, None) contents1.operations = [(ArrayObject(props1.keys()), b"page1-contents")] contents2 = page2[NO("/Contents")] = ContentStream(None, None) contents2.operations = [(ArrayObject(props2.keys()), b"page2-contents")] expected_properties = { "/just1": "/just1-value", "/just2": "/just2-value", "/overlap-matching": "/overlap-matching-value", "/overlap-different": "/overlap-different-value1", "/overlap-different-0": "/overlap-different-value2", } expected_operations = [ # no renaming (ArrayObject(props1.keys()), b"page1-contents"), # some renaming ( ArrayObject( [ NO("/just2"), NO("/overlap-matching"), NO("/overlap-different-0"), ] ), b"page2-contents", ), ] # Act page1.merge_page(page2) # Assert assert page1[NO("/Resources")][NO("/Properties")] == expected_properties relevant_operations = [ (op, name) for op, name in page1.get_contents().operations if name in (b"page1-contents", b"page2-contents") ] assert relevant_operations == expected_operations @pytest.mark.enable_socket def test_merge_transformed_page_into_blank(): url = "https://github.com/py-pdf/pypdf/files/10768334/badges_3vjrh_7LXDZ_1-1.pdf" name = "badges_3vjrh_7LXDZ_1.pdf" r1 = PdfReader(BytesIO(get_data_from_url(url, name=name))) url = "https://github.com/py-pdf/pypdf/files/10768335/badges_3vjrh_7LXDZ_2-1.pdf" name = "badges_3vjrh_7LXDZ_2.pdf" r2 = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() writer.add_blank_page(100, 100) writer.pages[0].merge_translated_page(r1.pages[0], 0, 0, True, True) writer.pages[0].merge_translated_page(r2.pages[0], 1000, 1000, True, True) assert ( writer.pages[0]["/Resources"]["/Font"].raw_get("/F2+0").idnum != writer.pages[0]["/Resources"]["/Font"].raw_get("/F2+0-0").idnum ) writer.add_blank_page(100, 100) for x in range(4): for y in range(7): writer.pages[1].merge_translated_page( r1.pages[0], x * r1.pages[0].trimbox[2], y * r1.pages[0].trimbox[3], True, True, ) blank = PageObject.create_blank_page(width=100, height=100) assert blank.page_number is None inserted_blank = writer.add_page(blank) assert blank.page_number is None # the inserted page is a clone assert inserted_blank.page_number == len(writer.pages) - 1 writer.remove_page(inserted_blank.indirect_reference) assert inserted_blank.page_number is None inserted_blank = writer.add_page(blank) del writer._pages.get_object()["/Kids"][-1] assert inserted_blank.page_number is not None def test_pages_printing(): pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) assert str(reader.pages) == "[PageObject(0)]" assert len(reader.pages[0].images) == 0 with pytest.raises(KeyError): reader.pages[0].images["~1~"] @pytest.mark.enable_socket def test_del_pages(): url = "https://github.com/user-attachments/files/18381712/tika-941536.pdf" name = "tika-941536.pdf" writer = PdfWriter(clone_from=BytesIO(get_data_from_url(url, name=name))) ll = len(writer.pages) pp = writer.pages[1].indirect_reference del writer.pages[1] assert len(writer.pages) == ll - 1 pages = writer._pages.get_object() assert pages["/Count"] == ll - 1 assert len(pages["/Kids"]) == ll - 1 assert pp not in pages["/Kids"] del writer.pages[-2] with pytest.raises(TypeError): del writer.pages["aa"] with pytest.raises(IndexError): del writer.pages[9999] pp = tuple(p.indirect_reference for p in writer.pages[3:5]) ll = len(writer.pages) del writer.pages[3:5] assert len(writer.pages) == ll - 2 for p in pp: assert p not in pages["/Kids"] # del whole arborescence reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) # error case pp = reader.pages[2] i = pp["/Parent"].get_object()["/Kids"].index(pp.indirect_reference) del pp["/Parent"].get_object()["/Kids"][i] with pytest.raises(PdfReadError): del reader.pages[2] url = "https://github.com/py-pdf/pypdf/files/13946477/panda.pdf" name = "iss2343b.pdf" writer = PdfWriter(BytesIO(get_data_from_url(url, name=name)), incremental=True) node, idx = writer._get_page_in_node(53) assert (node.indirect_reference.idnum, idx) == (11776, 1) node, idx = writer._get_page_in_node(10000) assert (node.indirect_reference.idnum, idx) == (11769, -1) with pytest.raises(PyPdfError): writer._get_page_in_node(-1) del writer.pages[4] # to propagate among /Pages del writer.pages[:] assert len(writer.pages) == 0 assert len(writer.root_object["/Pages"]["/Kids"]) == 0 assert len(writer.flattened_pages) == 0 def test_pdf_pages_missing_type(): pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) del reader.trailer["/Root"]["/Pages"]["/Kids"][0].get_object()["/Type"] reader.pages[0] writer = PdfWriter(clone_from=reader) writer.pages[0] @pytest.mark.enable_socket def test_merge_with_stream_wrapped_in_save_restore(): """Test for issue #2587""" url = "https://github.com/py-pdf/pypdf/files/14895914/blank_portrait.pdf" name = "blank_portrait.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) page_one = reader.pages[0] assert page_one.get_contents().get_data() == b"q Q" page_two = reader.pages[0] page_one.merge_page(page_two) assert b"QQ" not in page_one.get_contents().get_data() @pytest.mark.samples def test_compression(): """Test for issue #1897""" def create_stamp_pdf() -> BytesIO: pytest.importorskip("fpdf") from fpdf import FPDF # noqa: PLC0415 pdf = FPDF() pdf.add_page() pdf.set_font("helvetica", "B", 16) pdf.cell(40, 10, "Hello World!") byte_string = pdf.output() return BytesIO(byte_string) template = PdfReader(create_stamp_pdf()) template_page = template.pages[0] writer = PdfWriter() writer.append(SAMPLE_ROOT / "009-pdflatex-geotopo/GeoTopo.pdf", [1]) nb1 = len(writer._objects) # 1 page only is modified for page in writer.pages: page.merge_page(template_page) # font is added; +1 streamobjects + 1 ArrayObject assert len(writer._objects) == nb1 + 1 + 2 for page in writer.pages: page.compress_content_streams() # objects are recycled assert len(writer._objects) == nb1 + 1 + 2 contents = writer.pages[0]["/Contents"] writer.pages[0].replace_contents(None) writer.pages[0].replace_contents(None) assert isinstance( writer._objects[contents.indirect_reference.idnum - 1], NullObject ) def test_merge_with_no_resources(): """Test for issue #2147""" writer = PdfWriter() p0 = writer.add_blank_page(900, 1200) del p0["/Resources"] p1 = writer.add_blank_page(900, 1200) del p1["/Resources"] writer.pages[0].merge_page(p1) def test_get_contents_from_nullobject(): """Issue #2157""" writer = PdfWriter() page1 = writer.add_blank_page(100, 100) page1[NameObject("/Contents")] = writer._add_object(NullObject()) assert page1.get_contents() is None page2 = writer.add_blank_page(100, 100) page1.merge_page(page2, over=True) @pytest.mark.enable_socket def test_pos_text_in_textvisitor(): """See #2200""" url = "https://github.com/py-pdf/pypdf/files/12675974/page_178.pdf" name = "test_text_pos.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) p = () def visitor_body2(text, cm, tm, fontdict, fontsize) -> None: nonlocal p if text.startswith("5425."): p = (tm[4], tm[5]) reader.pages[0].extract_text(visitor_text=visitor_body2) assert abs(p[0] - 323.5) < 0.1 assert abs(p[1] - 457.4) < 0.1 @pytest.mark.enable_socket def test_pos_text_in_textvisitor2(): """See #2075""" url = "https://github.com/py-pdf/pypdf/files/12318042/LegIndex-page6.pdf" name = "LegIndex-page6.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) x_lvl = 26 lst = [] def visitor_lvl(text, cm, tm, fontdict, fontsize) -> None: nonlocal x_lvl, lst if abs(tm[4] - x_lvl) < 2 and tm[5] < 740 and tm[5] > 210: lst.append(text.strip(" \n")) reader.pages[0].extract_text(visitor_text=visitor_lvl) assert lst == [ "ACUPUNCTURE BOARD", "ACUPUNCTURISTS AND ACUPUNCTURE", "ADMINISTRATIVE LAW AND PROCEDURE", "ADMINISTRATIVE LAW, OFFICE OF", "ADOPTION", "ADULT EDUCATION", "ADVERTISING. See also MARKETING; and particular subject matter (e.g.,", ] x_lvl = 35 lst = [] reader.pages[0].extract_text(visitor_text=visitor_lvl) assert lst == [ "members, AB 1264", "assistants, acupuncture, AB 1264", "complaints, investigations, etc., AB 1264", "day, california acupuncture, HR 48", "massage services, asian, AB 1264", "supervising acupuncturists, AB 1264", "supportive acupuncture services, basic, AB 1264", "rules and regulations—", "professional assistants and employees: employment and compensation, AB 916", "adults, adoption of, AB 1756", "agencies, organizations, etc.: requirements, prohibitions, etc., SB 807", "assistance programs, adoption: nonminor dependents, SB 9", "birth certificates, AB 1302", "contact agreements, postadoption—", "facilitators, adoption, AB 120", "failed adoptions: reproductive loss leave, SB 848", "hearings, adoption finalization: remote proceedings, technology, etc., SB 21", "native american tribes, AB 120", "parental rights, reinstatement of, AB 20", "parents, prospective adoptive: criminal background checks, SB 824", "services, adult educational, SB 877", "week, adult education, ACR 31", "alcoholic beverages: tied-house restrictions, AB 546", "campaign re social equity, civil rights, etc., SB 447", "cannabis, AB 794", "elections. See ELECTIONS.", "false, misleading, etc., advertising—", "hotels, short-term rentals, etc., advertised rates: mandatory fee disclosures, SB 683", "housing rental properties advertised rates: disclosures, SB 611", ] @pytest.mark.enable_socket def test_missing_basefont_in_type3(): """Cf #2289""" url = "https://github.com/py-pdf/pypdf/files/13307713/missing-base-font.pdf" name = "missing-base-font.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.pages[0]._get_fonts() def test_invalid_index(): src_abs = RESOURCE_ROOT / "git.pdf" reader = PdfReader(src_abs) with pytest.raises(TypeError): _ = reader.pages["0"] def test_negative_index(): src_abs = RESOURCE_ROOT / "git.pdf" reader = PdfReader(src_abs) assert reader.pages[0] == reader.pages[-1] def test_get_contents_as_bytes(): writer = PdfWriter(RESOURCE_ROOT / "crazyones.pdf") co = writer.pages[0]["/Contents"][0] expected = co.get_data() assert writer.pages[0]._get_contents_as_bytes() == expected writer.pages[0][NameObject("/Contents")] = writer.pages[0]["/Contents"][0] assert writer.pages[0]._get_contents_as_bytes() == expected del writer.pages[0]["/Contents"] assert writer.pages[0]._get_contents_as_bytes() is None def test_recursive_get_page_from_node(): writer = PdfWriter(RESOURCE_ROOT / "crazyones.pdf", incremental=True) writer.root_object["/Pages"].get_object()[ NameObject("/Parent") ] = writer.root_object["/Pages"].indirect_reference with pytest.raises(PyPdfError): writer.add_page(writer.pages[0]) writer = PdfWriter(RESOURCE_ROOT / "crazyones.pdf", incremental=True) writer.insert_page(writer.pages[0], -1) with pytest.raises(ValueError): writer.insert_page(writer.pages[0], -10) def test_get_contents__none_type(): # We can observe this in reality as well, but these documents might be # confidential. Thus use a more complex dummy implementation here while # assigning a value of `None` is not possible from code, but from PDFs # itself. class MyPage(PageObject): def __contains__(self, item) -> bool: assert item == "/Contents" return True def __getitem__(self, item) -> Any: assert item == "/Contents" page = MyPage() assert page.get_contents() is None def test_extract_text__none_type(): class MyPage(PageObject): def __getitem__(self, item) -> Any: if item == "/Contents": return None return super().__getitem__(item) page = MyPage() resources = DictionaryObject() none_reference = IndirectObject(1, 0, None) resources[NameObject("/Font")] = none_reference page[NameObject("/Resources")] = resources with mock.patch.object(none_reference, "get_object", return_value=None): assert page.extract_text() == "" pypdf-6.1.2/tests/test_page_labels.py000066400000000000000000000114401507516550200176610ustar00rootroot00000000000000"""Test the pypdf._page_labels module.""" from io import BytesIO from pathlib import Path import pytest from pypdf import PdfReader from pypdf._page_labels import ( get_label_from_nums, index2label, number2lowercase_letter, number2lowercase_roman_numeral, number2uppercase_letter, number2uppercase_roman_numeral, nums_clear_range, nums_insert, nums_next, ) from pypdf.generic import ( ArrayObject, DictionaryObject, NameObject, NullObject, NumberObject, ) from . import get_data_from_url TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" @pytest.mark.parametrize( ("number", "expected"), [ (1, "I"), (2, "II"), (3, "III"), (4, "IV"), (5, "V"), (6, "VI"), (7, "VII"), (8, "VIII"), (9, "IX"), (10, "X"), ], ) def test_number2uppercase_roman_numeral(number, expected): assert number2uppercase_roman_numeral(number) == expected def test_number2lowercase_roman_numeral(): assert number2lowercase_roman_numeral(123) == "cxxiii" @pytest.mark.parametrize( ("number", "expected"), [ (1, "a"), (2, "b"), (3, "c"), (25, "y"), (26, "z"), (27, "aa"), (28, "ab"), ], ) def test_number2lowercase_letter(number, expected): assert number2lowercase_letter(number) == expected def test_number2uppercase_letter(): with pytest.raises(ValueError): number2uppercase_letter(-1) @pytest.mark.enable_socket def test_index2label(caplog): name = "waarom-meisjes-het-beter-doen-op-HAVO-en-VWO-ROA.pdf" r = PdfReader(BytesIO(get_data_from_url(name=name))) assert index2label(r, 1) == "ii" assert index2label(r, 9) == "6" # very silly data to get test cover r.trailer["/Root"]["/PageLabels"]["/Nums"].append(8) r.trailer["/Root"]["/PageLabels"]["/Nums"].append(NullObject()) assert index2label(r, 9) == "10" with pytest.raises(ValueError): nums_clear_range( NumberObject(10), 8, r.trailer["/Root"]["/PageLabels"]["/Nums"] ) r.trailer["/Root"]["/PageLabels"]["/Nums"].append(8) with pytest.raises(ValueError): nums_next(NumberObject(10), r.trailer["/Root"]["/PageLabels"]["/Nums"]) with pytest.raises(ValueError): nums_clear_range( NumberObject(10), 8, r.trailer["/Root"]["/PageLabels"]["/Nums"] ) with pytest.raises(ValueError): nums_insert( NumberObject(10), DictionaryObject(), r.trailer["/Root"]["/PageLabels"]["/Nums"], ) del r.trailer["/Root"]["/PageLabels"]["/Nums"] assert index2label(r, 1) == "2" caplog.clear() r.trailer["/Root"]["/PageLabels"][NameObject("/Kids")] = NullObject() assert index2label(r, 1) == "2" assert caplog.text != "" @pytest.mark.enable_socket def test_index2label_kids(): url = "https://github.com/py-pdf/pypdf/files/14858124/Terminologie_Epochen.Schwerpunkte.Umsetzungen.pdf" r = PdfReader(BytesIO(get_data_from_url(url=url, name="index2label_kids.pdf"))) expected = [ "C1", "I", "II", "III", "IV", "V", "VI", "VII", "VIII", "IX", "X", "XI", "XII", "XIII", "XIV", "XV", "XVI", "XVII", *list(map(str, range(1, 284))) ] for x in ["20", "44", "58", "82", "94", "116", "154", "166", "192", "224", "250"]: # Some page labels are unused. Removing them is still easier than copying the # whole list itself here. expected.remove(x) assert r.page_labels == expected @pytest.mark.enable_socket def test_index2label_kids__recursive(caplog): url = "https://github.com/py-pdf/pypdf/files/14842446/tt1.pdf" r = PdfReader( BytesIO(get_data_from_url(url=url, name="index2label_kids_recursive.pdf")) ) expected = [ "A", "B", "C", "D", "E", "F", "G", "H", "I", "J", "K", "L", "M", "N", "O", "P", "17", "18", "19", ] assert r.page_labels == expected assert caplog.text != "" def test_get_label_from_nums__empty_nums_list(): dictionary_object = DictionaryObject() dictionary_object[NameObject("/Nums")] = ArrayObject() assert get_label_from_nums(dictionary_object, 13) == "14" def test_index2label__empty_kids_list(): reader = PdfReader(RESOURCE_ROOT / "crazyones.pdf") number_tree = DictionaryObject() number_tree[NameObject("/Kids")] = ArrayObject() root = reader.root_object root[NameObject("/PageLabels")] = number_tree assert index2label(reader, 42) == "43" pypdf-6.1.2/tests/test_pagerange.py000066400000000000000000000071011507516550200173530ustar00rootroot00000000000000"""Test the pypdf.pagerange module.""" import pytest from pypdf.pagerange import PageRange, ParseError, parse_filename_page_ranges def test_equality(): pr1 = PageRange(slice(0, 5)) pr2 = PageRange(slice(0, 5)) assert pr1 == pr2 def test_hash(): pr1 = PageRange(slice(0, 5)) pr2 = PageRange(slice(0, 5)) pr3 = PageRange(slice(10, 11)) pr4 = PageRange(slice(10, 11, 1)) assert hash(pr1) == hash(pr2) assert hash(pr1) != hash(pr3) # Consider this different for now, although slicing with step size of 1 and `None` should be identical. assert hash(pr3) != hash(pr4) @pytest.mark.parametrize( ("page_range", "expected"), [(slice(0, 5), "0:5"), (slice(0, 5, 2), "0:5:2"), ("-1", "-1:"), ("0", "0")], ) def test_str(page_range, expected): assert str(PageRange(page_range)) == expected @pytest.mark.parametrize( ("page_range", "expected"), [(slice(0, 5), "PageRange('0:5')"), (slice(0, 5, 2), "PageRange('0:5:2')")], ) def test_repr(page_range, expected): assert repr(PageRange(page_range)) == expected def test_equality_other_objectc(): pr1 = PageRange(slice(0, 5)) pr2 = "PageRange(slice(0, 5))" assert pr1 != pr2 def test_idempotency(): pr = PageRange(slice(0, 5)) pr2 = PageRange(pr) assert pr == pr2 @pytest.mark.parametrize( ("range_str", "expected"), [ ("42", slice(42, 43)), ("1:2", slice(1, 2)), ], ) def test_str_init(range_str, expected): pr = PageRange(range_str) assert pr._slice == expected assert PageRange.valid def test_str_init_error(): init_str = "1-2" assert PageRange.valid(init_str) is False with pytest.raises(ParseError) as exc: PageRange(init_str) assert exc.value.args[0] == "1-2" @pytest.mark.parametrize( ("params", "expected"), [ (["foo.pdf", "1:5"], [("foo.pdf", PageRange("1:5"))]), ( ["foo.pdf", "1:5", "bar.pdf"], [("foo.pdf", PageRange("1:5")), ("bar.pdf", PageRange(":"))], ), ], ) def test_parse_filename_page_ranges(params, expected): assert parse_filename_page_ranges(params) == expected def test_parse_filename_page_ranges_err(): with pytest.raises(ValueError) as exc: parse_filename_page_ranges(["1:5", "foo.pdf"]) assert ( exc.value.args[0] == "The first argument must be a filename, not a page range." ) @pytest.mark.parametrize( ("a", "b", "expected"), [ (PageRange(slice(0, 5)), PageRange(slice(2, 10)), slice(0, 10)), (PageRange(slice(0, 5)), PageRange(slice(2, 3)), slice(0, 5)), (PageRange(slice(0, 5)), PageRange(slice(5, 10)), slice(0, 10)), ], ) def test_addition(a, b, expected): pr1 = PageRange(a) pr2 = PageRange(b) assert pr1 + pr2 == PageRange(expected) assert pr2 + pr1 == PageRange(expected) # addition is commutative @pytest.mark.parametrize( ("a", "b"), [ (PageRange(slice(0, 5)), PageRange(slice(7, 10))), (PageRange(slice(7, 10)), PageRange(slice(0, 5))), ], ) def test_addition_gap(a: PageRange, b: PageRange): with pytest.raises(ValueError) as exc: a + b assert exc.value.args[0] == "Can't add PageRanges with gap" def test_addition_non_page_range(): with pytest.raises(TypeError) as exc: PageRange(slice(0, 5)) + "2:7" assert exc.value.args[0] == "Can't add PageRange and " def test_addition_stride(): a = PageRange(slice(0, 5, 2)) b = PageRange(slice(7, 9)) with pytest.raises(ValueError) as exc: a + b assert exc.value.args[0] == "Can't add PageRange with stride" pypdf-6.1.2/tests/test_papersizes.py000066400000000000000000000022551507516550200176140ustar00rootroot00000000000000"""Test the pypdf.papersizes module.""" import pytest from pypdf import papersizes def test_din_a0_paper_size(): """The dimensions and area of the DIN A0 paper size are correct.""" dim = papersizes.PaperSize.A0 area_square_pixels = float(dim.width) * dim.height # 72 pixels is 1 inch area_square_inch = area_square_pixels / 72**2 # 25.4 millimeter is equal to 1 inches area_square_mm = area_square_inch * (25.4) ** 2 assert abs(area_square_mm - 999949) < 100 conversion_factor = 72 / 25.4 assert (dim.width - 841 * conversion_factor) < 1 assert (dim.width - 1189 * conversion_factor) < 1 @pytest.mark.parametrize("dimensions", papersizes._din_a) def test_din_a_aspect_ratio(dimensions): """The aspect ratio of DIN A paper sizes is correct.""" assert abs(dimensions.height - dimensions.width * 2**0.5) <= 2.5 @pytest.mark.parametrize( ("dimensions_a", "dimensions_b"), list(zip(papersizes._din_a, papersizes._din_a[1:])), ) def test_din_a_size_doubling(dimensions_a, dimensions_b): """The height of a DIN A paper size doubles when moving to the next size.""" assert abs(dimensions_a.height - 2 * dimensions_b.width) <= 4 pypdf-6.1.2/tests/test_pdfa.py000066400000000000000000000030171507516550200163360ustar00rootroot00000000000000"""Ensure that pypdf doesn't break PDF/A compliance.""" from io import BytesIO from pathlib import Path from typing import Optional import pytest from pypdf import PdfReader, PdfWriter TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" SAMPLE_ROOT = PROJECT_ROOT / "sample-files" def is_pdfa1b_compliant(src: BytesIO): """Check if a PDF is PDF/A-1b compliant.""" def document_information_has_analoguos_xml(src: BytesIO) -> bool: reader = PdfReader(src) meta = reader.metadata xmp = reader.xmp_metadata if not meta: return True if not xmp: return False if meta.title and not xmp.dc_title: return meta.title == xmp.dc_title return True return document_information_has_analoguos_xml(src) @pytest.mark.samples @pytest.mark.parametrize( ("src", "diagnostic_write_name"), [ (SAMPLE_ROOT / "021-pdfa/crazyones-pdfa.pdf", None), ], ) def test_pdfa(src: Path, diagnostic_write_name: Optional[str]): with open(src, "rb") as fp: data = BytesIO(fp.read()) reader = PdfReader(src) assert is_pdfa1b_compliant(data) writer = PdfWriter() writer.clone_document_from_reader(reader) stream = BytesIO() writer.write(stream) stream.seek(0) assert is_pdfa1b_compliant(stream) if diagnostic_write_name: with open(diagnostic_write_name, "wb") as fp: stream.seek(0) fp.write(stream.read()) pypdf-6.1.2/tests/test_protocols.py000066400000000000000000000006331507516550200174510ustar00rootroot00000000000000"""Test the pypdf._protocols module.""" from pypdf._protocols import PdfObjectProtocol class IPdfObjectProtocol(PdfObjectProtocol): pass def test_pdfobjectprotocol(): o = IPdfObjectProtocol() assert o.clone(None, False, None) is None assert o._reference_clone(None, None) is None assert o.get_object() is None assert o.hash_value() is None assert o.write_to_stream(None) is None pypdf-6.1.2/tests/test_reader.py000066400000000000000000001636061507516550200167010ustar00rootroot00000000000000"""Test the pypdf._reader module.""" import io import time from io import BytesIO from pathlib import Path from typing import Union import pytest from pypdf import PdfReader, PdfWriter from pypdf._crypt_providers import crypt_provider from pypdf._reader import convert_to_int from pypdf.constants import ImageAttributes as IA from pypdf.constants import PageAttributes as PG from pypdf.constants import UserAccessPermissions as UAP from pypdf.errors import ( DeprecationError, EmptyFileError, FileNotDecryptedError, PdfReadError, PdfStreamError, WrongPasswordError, ) from pypdf.generic import ( ArrayObject, Destination, DictionaryObject, NameObject, NumberObject, TextStringObject, ) from . import get_data_from_url, normalize_warnings HAS_AES = crypt_provider[0] in ["pycryptodome", "cryptography"] TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" SAMPLE_ROOT = PROJECT_ROOT / "sample-files" NestedList = Union[int, None, list["NestedList"]] @pytest.mark.parametrize( ("src", "num_pages"), [("selenium-pypdf-issue-177.pdf", 1), ("pdflatex-outline.pdf", 4)], ) def test_get_num_pages(src, num_pages): src = RESOURCE_ROOT / src with PdfReader(src) as reader: assert len(reader.pages) == num_pages # from #1911 assert "/Size" in reader.trailer @pytest.mark.parametrize( ("pdf_path", "expected"), [ ( RESOURCE_ROOT / "crazyones.pdf", { "/CreationDate": "D:20150604133406-06'00'", "/Creator": " XeTeX output 2015.06.04:1334", "/Producer": "xdvipdfmx (20140317)", }, ), ( RESOURCE_ROOT / "metadata.pdf", { "/CreationDate": "D:20220415093243+02'00'", "/ModDate": "D:20220415093243+02'00'", "/Creator": "pdflatex, or other tool", "/Producer": "Latex with hyperref, or other system", "/Author": "Martin Thoma", "/Keywords": "Some Keywords, other keywords; more keywords", "/Subject": "The Subject", "/Title": "The Title", "/Trapped": "/False", "/PTEX.Fullbanner": ( "This is pdfTeX, Version " "3.141592653-2.6-1.40.23 (TeX Live 2021) " "kpathsea version 6.3.3" ), }, ), ], ids=["crazyones", "metadata"], ) def test_read_metadata(pdf_path, expected): with open(pdf_path, "rb") as inputfile: reader = PdfReader(inputfile) docinfo = reader.metadata assert docinfo is not None metadict = dict(docinfo) assert metadict == expected docinfo.title docinfo.title_raw docinfo.author docinfo.author_raw docinfo.creator docinfo.creator_raw docinfo.producer docinfo.producer_raw docinfo.subject docinfo.subject_raw docinfo.creation_date docinfo.creation_date_raw docinfo.modification_date docinfo.modification_date_raw docinfo.keywords docinfo.keywords_raw if "/Title" in metadict: assert isinstance(docinfo.title, str) assert metadict["/Title"] == docinfo.title def test_read_metadata_title_is_utf8(): with open(RESOURCE_ROOT / "bytes.pdf", "rb") as inputfile: reader = PdfReader(inputfile) title = reader.metadata.title # Should be a str. assert title == "Microsoft Word - ăă©ăłă‚ąăăĽă‚ąç¤ľč˛·ĺŹŽé›»č©±äĽšč­°č‹±čŞžFinal.docx" def test_iss1943(): with PdfReader(RESOURCE_ROOT / "crazyones.pdf") as reader: docinfo = reader.metadata docinfo.update( { NameObject("/CreationDate"): TextStringObject( "D:20230705005151Z00'00'" ), NameObject("/ModDate"): TextStringObject("D:20230705005151Z00'00'"), } ) docinfo.creation_date docinfo.creation_date_raw docinfo.modification_date docinfo.modification_date_raw docinfo.update({NameObject("/CreationDate"): NumberObject(1)}) assert docinfo.creation_date is None @pytest.mark.samples @pytest.mark.parametrize( "pdf_path", [SAMPLE_ROOT / "017-unreadable-meta-data/unreadablemetadata.pdf"] ) def test_broken_meta_data(pdf_path): with open(pdf_path, "rb") as f: reader = PdfReader(f) assert reader.metadata is None with open(RESOURCE_ROOT / "crazyones.pdf", "rb") as f: b = f.read(-1) reader = PdfReader(BytesIO(b.replace(b"/Info 2 0 R", b"/Info 2 "))) with pytest.raises(PdfReadError) as exc: reader.metadata assert "does not point to a document information dictionary" in repr(exc) @pytest.mark.parametrize( "src", [ RESOURCE_ROOT / "crazyones.pdf", RESOURCE_ROOT / "commented.pdf", ], ) def test_get_annotations(src): with PdfReader(src) as reader: for page in reader.pages: if PG.ANNOTS in page: for annot in page[PG.ANNOTS]: subtype = annot.get_object()[IA.SUBTYPE] if subtype == "/Text": annot.get_object()[PG.CONTENTS] @pytest.mark.parametrize( ("src", "nb_attachments"), [ (RESOURCE_ROOT / "attachment.pdf", 1), (RESOURCE_ROOT / "crazyones.pdf", 0), ], ) def test_get_attachments(src, nb_attachments): reader = PdfReader(src) attachments = {} for page in reader.pages: if PG.ANNOTS in page: for annotation in page[PG.ANNOTS]: annotobj = annotation.get_object() if annotobj[IA.SUBTYPE] == "/FileAttachment": fileobj = annotobj["/FS"] attachments[fileobj["/F"]] = fileobj["/EF"]["/F"].get_data() assert len(attachments) == nb_attachments @pytest.mark.parametrize( ("src", "outline_elements"), [ (RESOURCE_ROOT / "pdflatex-outline.pdf", 9), (RESOURCE_ROOT / "crazyones.pdf", 0), ], ) def test_get_outline(src, outline_elements): reader = PdfReader(src) outline = reader.outline assert len(outline) == outline_elements @pytest.mark.samples @pytest.mark.parametrize( ("src", "expected_images"), [ ("pdflatex-outline.pdf", []), ("crazyones.pdf", []), ("git.pdf", ["Image9.png"]), pytest.param( "imagemagick-lzw.pdf", ["Im0.png"], marks=pytest.mark.xfail(reason="broken image extraction"), ), pytest.param( "imagemagick-ASCII85Decode.pdf", ["Im0.png"], # marks=pytest.mark.xfail(reason="broken image extraction"), ), ("imagemagick-CCITTFaxDecode.pdf", ["Im0.tiff"]), (SAMPLE_ROOT / "019-grayscale-image/grayscale-image.pdf", ["X0.png"]), ], ) def test_get_images(src, expected_images): from PIL import Image # noqa: PLC0415 src_abs = RESOURCE_ROOT / src reader = PdfReader(src_abs) page = reader.pages[0] images_extracted = page.images assert len(images_extracted) == len(expected_images) for image, expected_image in zip(images_extracted, expected_images): assert image.name == expected_image assert ( image.name.split(".")[-1].upper() == Image.open(io.BytesIO(image.data)).format ) @pytest.mark.parametrize( ("strict", "with_prev_0", "startx_correction", "should_fail", "warning_msgs"), [ ( True, False, -1, False, [ "startxref on same line as offset", "Xref table not zero-indexed. " "ID numbers for objects will be corrected.", ], ), # all nominal => no fail (True, True, -1, True, ""), # Prev=0 => fail expected ( False, False, -1, False, [ "startxref on same line as offset", ], ), ( False, True, -1, False, [ "startxref on same line as offset", "/Prev=0 in the trailer - assuming there is no previous xref table", ], ), # Prev =0 => no strict so tolerant (True, False, 0, True, ""), # error on startxref, in strict => fail expected (True, True, 0, True, ""), ( False, False, 0, False, [ "startxref on same line as offset", "incorrect startxref pointer(1)", "parsing for Object Streams", ], ), # error on startxref, but no strict => xref rebuilt,no fail ( False, True, 0, False, [ "startxref on same line as offset", "incorrect startxref pointer(1)", "parsing for Object Streams", ], ), ], ) def test_get_images_raw( caplog, strict, with_prev_0, startx_correction, should_fail, warning_msgs ): pdf_data = ( b"%%PDF-1.7\n" b"1 0 obj << /Count 1 /Kids [4 0 R] /Type /Pages >> endobj\n" b"2 0 obj << >> endobj\n" b"3 0 obj << >> endobj\n" b"4 0 obj << /Contents 3 0 R /CropBox [0.0 0.0 2550.0 3508.0]" b" /MediaBox [0.0 0.0 2550.0 3508.0] /Parent 1 0 R" b" /Resources << /Font << >> >>" b" /Rotate 0 /Type /Page >> endobj\n" b"5 0 obj << /Pages 1 0 R /Type /Catalog >> endobj\n" b"xref 1 5\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"trailer << %s/Root 5 0 R /Size 6 >>\n" b"startxref %d\n" b"%%%%EOF" ) pdf_data = pdf_data % ( # - 1 below in the find because of the double % pdf_data.find(b"1 0 obj") - 1, pdf_data.find(b"2 0 obj") - 1, pdf_data.find(b"3 0 obj") - 1, pdf_data.find(b"4 0 obj") - 1, pdf_data.find(b"5 0 obj") - 1, b"/Prev 0 " if with_prev_0 else b"", # startx_correction should be -1 due to double % at the beginning # inducing an error on startxref computation pdf_data.find(b"xref") + startx_correction, ) pdf_stream = io.BytesIO(pdf_data) if should_fail: with pytest.raises(PdfReadError) as exc: PdfReader(pdf_stream, strict=strict) assert exc.type == PdfReadError if startx_correction == -1: assert ( exc.value.args[0] == "/Prev=0 in the trailer (try opening with strict=False)" ) else: PdfReader(pdf_stream, strict=strict) assert normalize_warnings(caplog.text) == warning_msgs def test_issue297(caplog): path = RESOURCE_ROOT / "issue-297.pdf" with pytest.raises(PdfReadError) as exc: reader = PdfReader(path, strict=True) assert caplog.text == "" assert "Broken xref table" in exc.value.args[0] reader = PdfReader(path, strict=False) assert normalize_warnings(caplog.text) == [ "incorrect startxref pointer(1)", "parsing for Object Streams", ] reader.pages[0] @pytest.mark.parametrize( ("pdffile", "password", "should_fail"), [ ("encrypted-file.pdf", "test", False), ("encrypted-file.pdf", b"test", False), ("encrypted-file.pdf", "qwerty", True), ("encrypted-file.pdf", b"qwerty", True), ], ) def test_get_page_of_encrypted_file(pdffile, password, should_fail): """ Check if we can read a page of an encrypted file. This is a regression test for issue 327: IndexError for get_page() of decrypted file """ path = RESOURCE_ROOT / pdffile if should_fail: with pytest.raises(PdfReadError): PdfReader(path, password=password) else: PdfReader(path, password=password).pages[0] @pytest.mark.parametrize( ("src", "expected", "expected_get_fields"), [ ( "form.pdf", {"foo": ""}, {"foo": {"/DV": "", "/FT": "/Tx", "/T": "foo", "/V": ""}}, ), ( "form_acrobatReader.pdf", {"foo": "Bar"}, {"foo": {"/DV": "", "/FT": "/Tx", "/T": "foo", "/V": "Bar"}}, ), ( "form_evince.pdf", {"foo": "bar"}, {"foo": {"/DV": "", "/FT": "/Tx", "/T": "foo", "/V": "bar"}}, ), ( "crazyones.pdf", {}, None, ), ], ) def test_get_form(src, expected, expected_get_fields, txt_file_path): """Check if we can read out form data.""" src = RESOURCE_ROOT / src reader = PdfReader(src) fields = reader.get_form_text_fields() assert fields == expected with open(txt_file_path, "w") as f: fields = reader.get_fields(fileobj=f) assert fields == expected_get_fields if fields: for field in fields.values(): # Just access the attributes [ field.field_type, field.parent, field.kids, field.name, field.alternate_name, field.mapping_name, field.flags, field.value, field.default_value, field.additional_actions, ] @pytest.mark.parametrize( ("src", "page_number"), [ ("form.pdf", 0), ("pdflatex-outline.pdf", 2), ], ) def test_get_page_number(src, page_number): src = RESOURCE_ROOT / src reader = PdfReader(src) reader.get_page(0) page = reader.pages[page_number] assert reader.get_page_number(page) == page_number @pytest.mark.parametrize( ("src", "expected"), [("form.pdf", None), ("AutoCad_Simple.pdf", "/SinglePage")], ) def test_get_page_layout(src, expected): src = RESOURCE_ROOT / src reader = PdfReader(src) assert reader.page_layout == expected @pytest.mark.parametrize( ("src", "expected"), [ ("form.pdf", "/UseNone"), ("crazyones.pdf", None), ], ) def test_get_page_mode(src, expected): src = RESOURCE_ROOT / src reader = PdfReader(src) assert reader.page_mode == expected def test_read_empty(): with pytest.raises(EmptyFileError) as exc: PdfReader(io.BytesIO()) assert exc.value.args[0] == "Cannot read an empty file" def test_read_malformed_header(caplog): with pytest.raises(PdfReadError) as exc: PdfReader(io.BytesIO(b"foo"), strict=True) assert exc.value.args[0] == "PDF starts with 'foo', but '%PDF-' expected" caplog.clear() try: PdfReader(io.BytesIO(b"foo"), strict=False) except Exception: pass assert caplog.messages[0].startswith("invalid pdf header") def test_read_malformed_body(): with pytest.raises(PdfReadError) as exc: PdfReader(io.BytesIO(b"%PDF-"), strict=True) assert ( exc.value.args[0] == "EOF marker not found" ) # used to be:STREAM_TRUNCATED_PREMATURELY def test_read_prev_0_trailer(): pdf_data = ( b"%%PDF-1.7\n" b"1 0 obj << /Count 1 /Kids [4 0 R] /Type /Pages >> endobj\n" b"2 0 obj << >> endobj\n" b"3 0 obj << >> endobj\n" b"4 0 obj << /Contents 3 0 R /CropBox [0.0 0.0 2550.0 3508.0]" b" /MediaBox [0.0 0.0 2550.0 3508.0] /Parent 1 0 R" b" /Resources << /Font << >> >>" b" /Rotate 0 /Type /Page >> endobj\n" b"5 0 obj << /Pages 1 0 R /Type /Catalog >> endobj\n" b"xref 1 5\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"trailer << %s/Root 5 0 R /Size 6 >>\n" b"startxref %d\n" b"%%%%EOF" ) with_prev_0 = True pdf_data = pdf_data % ( pdf_data.find(b"1 0 obj"), pdf_data.find(b"2 0 obj"), pdf_data.find(b"3 0 obj"), pdf_data.find(b"4 0 obj"), pdf_data.find(b"5 0 obj"), b"/Prev 0 " if with_prev_0 else b"", pdf_data.find(b"xref") - 1, ) pdf_stream = io.BytesIO(pdf_data) with pytest.raises(PdfReadError) as exc: PdfReader(pdf_stream, strict=True) assert exc.value.args[0] == "/Prev=0 in the trailer (try opening with strict=False)" def test_read_missing_startxref(): pdf_data = ( b"%%PDF-1.7\n" b"1 0 obj << /Count 1 /Kids [4 0 R] /Type /Pages >> endobj\n" b"2 0 obj << >> endobj\n" b"3 0 obj << >> endobj\n" b"4 0 obj << /Contents 3 0 R /CropBox [0.0 0.0 2550.0 3508.0]" b" /MediaBox [0.0 0.0 2550.0 3508.0] /Parent 1 0 R" b" /Resources << /Font << >> >>" b" /Rotate 0 /Type /Page >> endobj\n" b"5 0 obj << /Pages 1 0 R /Type /Catalog >> endobj\n" b"xref 1 5\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"trailer << /Root 5 0 R /Size 6 >>\n" # Removed for this test: b"startxref %d\n" b"%%%%EOF" ) pdf_data = pdf_data % ( pdf_data.find(b"1 0 obj"), pdf_data.find(b"2 0 obj"), pdf_data.find(b"3 0 obj"), pdf_data.find(b"4 0 obj"), pdf_data.find(b"5 0 obj"), # Removed for this test: pdf_data.find(b"xref") - 1, ) pdf_stream = io.BytesIO(pdf_data) with pytest.raises(PdfReadError) as exc: PdfReader(pdf_stream, strict=True) assert exc.value.args[0] == "startxref not found" def test_read_unknown_zero_pages(caplog): pdf_data = ( b"%%PDF-1.7\n" b"1 0 obj << /Count 1 /Kids [4 0 R] /Type /Pages >> endobj\n" b"2 0 obj << >> endobj\n" b"3 0 obj << >> endobj\n" b"4 0 obj << /Contents 3 0 R /CropBox [0.0 0.0 2550.0 3508.0]" b" /MediaBox [0.0 0.0 2550.0 3508.0] /Parent 1 0 R" b" /Resources << /Font << >> >>" b" /Rotate 0 /Type /Page >> endobj\n" # Pages 0 0 is the key point: b"5 0 obj << /Pages 0 0 R /Type /Catalog >> endobj\n" b"xref 1 5\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"trailer << /Root 5 1 R /Size 6 >>\n" b"startxref %d\n" b"%%%%EOF" ) pdf_data = pdf_data % ( pdf_data.find(b"1 0 obj") - 1, pdf_data.find(b"2 0 obj") - 1, pdf_data.find(b"3 0 obj") - 1, pdf_data.find(b"4 0 obj") - 1, pdf_data.find(b"5 0 obj") - 1, pdf_data.find(b"xref") - 1, ) pdf_stream = io.BytesIO(pdf_data) reader = PdfReader(pdf_stream, strict=True) warnings = [ "startxref on same line as offset", "Xref table not zero-indexed. ID numbers for objects will be corrected.", ] assert normalize_warnings(caplog.text) == warnings with pytest.raises(PdfReadError) as exc: len(reader.pages) assert exc.value.args[0] == "Could not find object." reader = PdfReader(pdf_stream, strict=False) warnings += [ "Object 5 1 not defined.", "startxref on same line as offset", ] assert normalize_warnings(caplog.text) == warnings with pytest.raises(PdfReadError) as exc: len(reader.pages) assert exc.value.args[0] == "Invalid object in /Pages" def test_read_encrypted_without_decryption(): src = RESOURCE_ROOT / "libreoffice-writer-password.pdf" reader = PdfReader(src) with pytest.raises(FileNotDecryptedError) as exc: len(reader.pages) assert exc.value.args[0] == "File has not been decrypted" def test_get_destination_page_number(): src = RESOURCE_ROOT / "pdflatex-outline.pdf" reader = PdfReader(src) outline = reader.outline for outline_item in outline: if not isinstance(outline_item, list): reader.get_destination_page_number(outline_item) def test_do_not_get_stuck_on_large_files_without_start_xref(): """ Tests for the absence of a DoS bug, where a large file without an startxref mark would cause the library to hang for minutes to hours. """ start_time = time.time() broken_stream = BytesIO(b"\0" * 5 * 1000 * 1000) with pytest.raises(PdfReadError): PdfReader(broken_stream) parse_duration = time.time() - start_time # parsing is expected take less than a second on a modern cpu, but include # a large tolerance to account for busy or slow systems assert parse_duration < 60 @pytest.mark.enable_socket def test_decrypt_when_no_id(): """ Decrypt an encrypted file that's missing the 'ID' value in its trailer. https://github.com/py-pdf/pypdf/issues/608 """ with open(RESOURCE_ROOT / "encrypted_doc_no_id.pdf", "rb") as inputfile: ipdf = PdfReader(inputfile) ipdf.decrypt("") assert ipdf.metadata == {"/Producer": "European Patent Office"} def test_reader_properties(): reader = PdfReader(RESOURCE_ROOT / "crazyones.pdf") assert reader.outline == [] assert len(reader.pages) == 1 assert reader.page_layout is None assert reader.page_mode is None assert reader.is_encrypted is False @pytest.mark.parametrize( "strict", [True, False], ) def test_issue604(caplog, strict): """Test with invalid destinations.""" with open(RESOURCE_ROOT / "issue-604.pdf", "rb") as f: pdf = None outline = None if strict: pdf = PdfReader(f, strict=strict) with pytest.raises(PdfReadError) as exc: outline = pdf.outline if "Unknown Destination" not in exc.value.args[0]: raise Exception("Expected exception not raised") return # outline is not correct pdf = PdfReader(f, strict=strict) outline = pdf.outline msg = [ "Unknown destination: 'ms_Thyroid_2_2020_071520_watermarked.pdf' [0, 1]" ] assert normalize_warnings(caplog.text) == msg def get_dest_pages(x) -> NestedList: if isinstance(x, list): return [get_dest_pages(y) for y in x] destination_page_number = pdf.get_destination_page_number(x) if destination_page_number is None: return destination_page_number return destination_page_number + 1 out = [] # oi can be destination or a list:preferred to just print them for oi in outline: out.append(get_dest_pages(oi)) # noqa: PERF401 def test_decode_permissions(): reader = PdfReader(RESOURCE_ROOT / "crazyones.pdf") base = { "accessability": False, # Do not fix typo, as part of official, but deprecated API. "annotations": False, "assemble": False, "copy": False, "forms": False, "modify": False, "print_high_quality": False, "print": False, } print_ = base.copy() print_["print"] = True with pytest.raises( DeprecationError, match=( r"decode_permissions is deprecated and was removed in pypdf 5\.0\.0\. " r"Use user_access_permissions instead" ), ): assert reader.decode_permissions(4) == print_ modify = base.copy() modify["modify"] = True with pytest.raises( DeprecationError, match=( r"decode_permissions is deprecated and was removed in pypdf 5\.0\.0\. " r"Use user_access_permissions instead" ), ): assert reader.decode_permissions(8) == modify @pytest.mark.skipif(not HAS_AES, reason="No AES implementation") def test_user_access_permissions(): # Not encrypted. reader = PdfReader(RESOURCE_ROOT / "crazyones.pdf") assert reader.user_access_permissions is None # Encrypted. reader = PdfReader(RESOURCE_ROOT / "encryption" / "r6-owner-password.pdf") assert reader.user_access_permissions == UAP.all() # Custom writer permissions. writer = PdfWriter(clone_from=RESOURCE_ROOT / "crazyones.pdf") writer.encrypt( user_password="", owner_password="abc", permissions_flag=UAP.PRINT | UAP.FILL_FORM_FIELDS, ) output = BytesIO() writer.write(output) reader = PdfReader(output) assert reader.user_access_permissions == (UAP.PRINT | UAP.FILL_FORM_FIELDS) # All writer permissions. writer = PdfWriter(clone_from=RESOURCE_ROOT / "crazyones.pdf") writer.encrypt( user_password="", owner_password="abc", permissions_flag=UAP.all(), ) output = BytesIO() writer.write(output) reader = PdfReader(output) assert reader.user_access_permissions == UAP.all() def test_pages_attribute(): pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) # Test if getting as slice throws an error assert len(reader.pages[:]) == 1 with pytest.raises(IndexError) as exc: reader.pages[-1000] assert exc.value.args[0] == "Sequence index out of range" with pytest.raises(IndexError): reader.pages[1000] assert exc.value.args[0] == "Sequence index out of range" def test_convert_to_int(): assert convert_to_int(b"\x01", 8) == 1 def test_convert_to_int_error(): with pytest.raises(PdfReadError) as exc: convert_to_int(b"256", 16) assert exc.value.args[0] == "Invalid size in convert_to_int" @pytest.mark.enable_socket def test_iss925(): url = "https://github.com/py-pdf/pypdf/files/8796328/1.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name="iss925.pdf"))) for page_sliced in reader.pages: page_object = page_sliced.get_object() # Extracts the PDF's Annots (Annotations and Commenting): annots = page_object.get("/Annots") if annots is not None: for annot in annots: annot.get_object() def test_get_object(): reader = PdfReader(RESOURCE_ROOT / "hello-world.pdf") assert reader.get_object(22)["/Type"] == "/Catalog" assert reader._get_indirect_object(22, 0)["/Type"] == "/Catalog" def test_extract_text_hello_world(): reader = PdfReader(RESOURCE_ROOT / "hello-world.pdf") text = reader.pages[0].extract_text().split("\n") assert text == [ "English:", "Hello World", "Arabic:", "مرحبا بالعالم", "Russian:", "Привет, мир", "Chinese (traditional):", "你好世界", "Thai:", "สวัสดีชาวโลŕ¸", "Japanese:", "ă“ă‚“ă«ăˇăŻä¸–ç•Ś", ] def test_read_path(): path = Path(RESOURCE_ROOT, "crazyones.pdf") reader = PdfReader(path) assert len(reader.pages) == 1 def test_read_not_binary_mode(caplog): with open(RESOURCE_ROOT / "crazyones.pdf") as f: msg = ( "PdfReader stream/file object is not in binary mode. " "It may not be read correctly." ) with pytest.raises(io.UnsupportedOperation): PdfReader(f) assert normalize_warnings(caplog.text) == [msg] @pytest.mark.enable_socket @pytest.mark.skipif(not HAS_AES, reason="No AES algorithm available") def test_read_form_416(): url = ( "https://www.fda.gov/downloads/AboutFDA/ReportsManualsForms/Forms/UCM074728.pdf" ) reader = PdfReader(BytesIO(get_data_from_url(url, name="issue_416.pdf"))) fields = reader.get_form_text_fields() assert len(fields) > 0 def test_form_topname_with_and_without_acroform(caplog): r = PdfReader(RESOURCE_ROOT / "crazyones.pdf") r.add_form_topname("no") r.rename_form_topname("renamed") assert "/AcroForm" not in r.trailer["/Root"] r.trailer["/Root"][NameObject("/AcroForm")] = DictionaryObject() r.add_form_topname("toto") r.rename_form_topname("renamed") assert len(r.get_fields()) == 0 r = PdfReader(RESOURCE_ROOT / "form.pdf") r.add_form_topname("top") flds = r.get_fields() assert "top" in flds assert "top.foo" in flds r.rename_form_topname("renamed") flds = r.get_fields() assert "renamed" in flds assert "renamed.foo" in flds r = PdfReader(RESOURCE_ROOT / "form.pdf") r.get_fields()["foo"].indirect_reference.get_object()[ NameObject("/Parent") ] = DictionaryObject() r.add_form_topname("top") assert "have a non-expected parent" in caplog.text @pytest.mark.enable_socket def test_extract_text_xref_issue_2(caplog): # pdf/0264cf510015b2a4b395a15cb23c001e.pdf url = "https://github.com/user-attachments/files/18381758/tika-981961.pdf" msg = [ "incorrect startxref pointer(2)", "parsing for Object Streams", ] reader = PdfReader(BytesIO(get_data_from_url(url, name="tika-981961.pdf"))) for page in reader.pages: page.extract_text() assert normalize_warnings(caplog.text) == msg @pytest.mark.enable_socket @pytest.mark.slow def test_extract_text_xref_issue_3(caplog): # pdf/0264cf510015b2a4b395a15cb23c001e.pdf url = "https://github.com/user-attachments/files/18381755/tika-977774.pdf" msg = [ "incorrect startxref pointer(3)", ] reader = PdfReader(BytesIO(get_data_from_url(url, name="tika-977774.pdf"))) for page in reader.pages: page.extract_text() assert normalize_warnings(caplog.text) == msg @pytest.mark.enable_socket def test_extract_text_pdf15(): # pdf/0264cf510015b2a4b395a15cb23c001e.pdf url = "https://github.com/user-attachments/files/18381751/tika-976030.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name="tika-976030.pdf"))) for page in reader.pages: page.extract_text() @pytest.mark.enable_socket def test_extract_text_xref_table_21_bytes_clrf(): # pdf/0264cf510015b2a4b395a15cb23c001e.pdf url = "https://github.com/user-attachments/files/18381723/tika-956939.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name="tika-956939.pdf"))) for page in reader.pages: page.extract_text() @pytest.mark.enable_socket def test_get_fields(): url = "https://github.com/user-attachments/files/18381747/tika-972486.pdf" name = "tika-972486.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) fields = reader.get_fields() assert fields is not None assert "c1-1" in fields assert dict(fields["c1-1"]) == ( {"/FT": "/Btn", "/T": "c1-1", "/_States_": ["/On", "/Off"]} ) @pytest.mark.enable_socket def test_get_full_qualified_fields(): url = "https://github.com/py-pdf/pypdf/files/10142389/fields_with_dots.pdf" name = "fields_with_dots.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) fields = reader.get_form_text_fields(True) assert fields is not None assert "customer.name" in fields fields = reader.get_form_text_fields(False) assert fields is not None assert "customer.name" not in fields assert "name" in fields fields = reader.get_fields(True) assert fields is not None assert "customer.name" in fields assert fields["customer.name"]["/T"] == "name" @pytest.mark.enable_socket @pytest.mark.filterwarnings("ignore::pypdf.errors.PdfReadWarning") def test_get_fields_read_else_block(): # covers also issue 1089 url = "https://github.com/user-attachments/files/18381705/tika-934771.pdf" name = "tika-934771.pdf" PdfReader(BytesIO(get_data_from_url(url, name=name))) @pytest.mark.enable_socket def test_get_fields_read_else_block2(): url = "https://github.com/user-attachments/files/18381689/tika-914902.pdf" name = "tika-914902.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) fields = reader.get_fields() assert fields is None @pytest.mark.enable_socket @pytest.mark.filterwarnings("ignore::pypdf.errors.PdfReadWarning") def test_get_fields_read_else_block3(): url = "https://github.com/user-attachments/files/18381726/tika-957721.pdf" name = "tika-957721.pdf" PdfReader(BytesIO(get_data_from_url(url, name=name))) @pytest.mark.enable_socket def test_metadata_is_none(): url = "https://github.com/user-attachments/files/18381735/tika-963692.pdf" name = "tika-963692.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert reader.metadata is None @pytest.mark.enable_socket def test_get_fields_read_write_report(txt_file_path): url = "https://github.com/user-attachments/files/18381683/tika-909655.pdf" name = "tika-909655.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) with open(txt_file_path, "w") as fp: fields = reader.get_fields(fileobj=fp) assert fields @pytest.mark.parametrize( "src", [ RESOURCE_ROOT / "crazyones.pdf", RESOURCE_ROOT / "commented.pdf", ], ) def test_xfa(src): reader = PdfReader(src) assert reader.xfa is None @pytest.mark.enable_socket def test_xfa_non_empty(): url = "https://github.com/user-attachments/files/18381713/tika-942050.pdf" name = "tika-942050.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert list(reader.xfa.keys()) == [ "preamble", "config", "template", "PDFSecurity", "datasets", "postamble", ] @pytest.mark.parametrize( ("src", "pdf_header"), [ (RESOURCE_ROOT / "attachment.pdf", "%PDF-1.5"), (RESOURCE_ROOT / "crazyones.pdf", "%PDF-1.5"), ], ) def test_header(src, pdf_header): reader = PdfReader(src) assert reader.pdf_header == pdf_header @pytest.mark.enable_socket def test_outline_color(): reader = PdfReader(BytesIO(get_data_from_url(name="tika-924546.pdf"))) assert reader.outline[0].color == [0, 0, 1] @pytest.mark.enable_socket def test_outline_font_format(): reader = PdfReader(BytesIO(get_data_from_url(name="tika-924546.pdf"))) assert reader.outline[0].font_format == 2 def get_outline_property(outline, attribute_name: str): results = [] if isinstance(outline, list): for outline_item in outline: if isinstance(outline_item, Destination): results.append(getattr(outline_item, attribute_name)) else: results.append(get_outline_property(outline_item, attribute_name)) else: raise ValueError(f"got {type(outline)}") return results @pytest.mark.samples def test_outline_title_issue_1121(): reader = PdfReader(SAMPLE_ROOT / "014-outlines/mistitled_outlines_example.pdf") assert get_outline_property(reader.outline, "title") == [ "First", [ "Second", "Third", "Fourth", [ "Fifth", "Sixth", ], "Seventh", [ "Eighth", "Ninth", ], ], "Tenth", [ "Eleventh", "Twelfth", "Thirteenth", "Fourteenth", ], "Fifteenth", [ "Sixteenth", "Seventeenth", ], "Eighteenth", "Nineteenth", [ "Twentieth", "Twenty-first", "Twenty-second", "Twenty-third", "Twenty-fourth", "Twenty-fifth", "Twenty-sixth", "Twenty-seventh", ], ] @pytest.mark.samples def test_outline_count(): reader = PdfReader(SAMPLE_ROOT / "014-outlines/mistitled_outlines_example.pdf") assert get_outline_property(reader.outline, "outline_count") == [ 5, [ None, None, 2, [ None, None, ], -2, [ None, None, ], ], 4, [ None, None, None, None, ], -2, [ None, None, ], None, 8, [ None, None, None, None, None, None, None, None, ], ] def test_outline_missing_title(caplog): # Strict reader = PdfReader(RESOURCE_ROOT / "outline-without-title.pdf", strict=True) with pytest.raises(PdfReadError) as exc: reader.outline assert exc.value.args[0].startswith("Outline Entry Missing /Title attribute:") # Non-strict : no errors reader = PdfReader(RESOURCE_ROOT / "outline-without-title.pdf", strict=False) assert reader.outline[0]["/Title"] == "" @pytest.mark.enable_socket @pytest.mark.parametrize( ("url", "name"), [ # 1st case : the named_dest are stored directly as a dictionary, PDF 1.1 style ( "https://github.com/py-pdf/pypdf/files/9197028/lorem_ipsum.pdf", "lorem_ipsum.pdf", ), # 2nd case : Dest below names and with Kids... ( "https://github.com/py-pdf/pypdf/files/11714214/PDF32000_2008.pdf", "PDF32000_2008.pdf", ) # 3rd case : Dests with Name tree (TODO: Add this case) ], ids=["stored_directly", "dest_below_names_with_kids"], ) def test_named_destination(url, name): reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert len(reader.named_destinations) > 0 @pytest.mark.enable_socket def test_outline_with_missing_named_destination(): url = "https://github.com/user-attachments/files/18381686/tika-913678.pdf" name = "tika-913678.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) # outline items in document reference a named destination that is not defined assert reader.outline[1][0].title.startswith("Report for 2002AZ3B: Microbial") @pytest.mark.enable_socket def test_outline_with_empty_action(): url = "https://github.com/user-attachments/files/18381697/tika-924546.pdf" name = "tika-924546.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) # outline items (entitled Tables and Figures) utilize an empty action (/A) # that has no type or destination assert reader.outline[-4].title == "Tables" def test_outline_with_invalid_destinations(): reader = PdfReader(RESOURCE_ROOT / "outlines-with-invalid-destinations.pdf") # contains 9 outline items, 6 with invalid destinations # caused by different malformations assert len(reader.outline) == 9 @pytest.mark.enable_socket def test_pdfreader_multiple_definitions(caplog): """iss325""" url = "https://github.com/py-pdf/pypdf/files/9176644/multipledefs.pdf" name = "multipledefs.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.pages[0].extract_text() assert normalize_warnings(caplog.text) == [ "Multiple definitions in dictionary at byte 0xb5 for key /Group" ] def test_wrong_password_error(): encrypted_pdf_path = RESOURCE_ROOT / "encrypted-file.pdf" with pytest.raises(WrongPasswordError): PdfReader( encrypted_pdf_path, password="definitely_the_wrong_password!", ) def test_get_page_number_by_indirect(): reader = PdfReader(RESOURCE_ROOT / "crazyones.pdf") reader._get_page_number_by_indirect(1) @pytest.mark.enable_socket def test_corrupted_xref_table(): # issue #1292 url = "https://github.com/py-pdf/pypdf/files/9444747/BreezeManual.orig.pdf" name = "BreezeMan1.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.pages[0].extract_text() url = "https://github.com/py-pdf/pypdf/files/9444748/BreezeManual.failed.pdf" name = "BreezeMan2.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.pages[0].extract_text() @pytest.mark.enable_socket def test_reader(caplog): # iss #1273 url = "https://github.com/py-pdf/pypdf/files/9464742/shiv_resume.pdf" name = "shiv_resume.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert "Previous trailer cannot be read" in caplog.text caplog.clear() # first call requires some reparations... reader.pages[0].extract_text() caplog.clear() # ...and now no more required reader.pages[0].extract_text() assert caplog.text == "" @pytest.mark.enable_socket def test_zeroing_xref(): # iss #328 url = ( "https://github.com/py-pdf/pypdf/files/9066120/" "UTA_OSHA_3115_Fall_Protection_Training_09162021_.pdf" ) name = "UTA_OSHA.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) len(reader.pages) @pytest.mark.enable_socket def test_thread(): url = ( "https://github.com/py-pdf/pypdf/files/9066120/" "UTA_OSHA_3115_Fall_Protection_Training_09162021_.pdf" ) name = "UTA_OSHA.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert reader.threads is None url = "https://github.com/user-attachments/files/18381699/tika-924666.pdf" name = "tika-924666.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert isinstance(reader.threads, ArrayObject) assert len(reader.threads) >= 1 @pytest.mark.enable_socket def test_build_outline_item(caplog): url = "https://github.com/py-pdf/pypdf/files/9464742/shiv_resume.pdf" name = "shiv_resume.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) outline = reader._build_outline_item( DictionaryObject( { NameObject("/Title"): TextStringObject("Toto"), NameObject("/Dest"): NumberObject(2), } ) ) assert "Removed unexpected destination 2 from destination" in caplog.text assert outline["/Title"] == "Toto" reader.strict = True with pytest.raises(PdfReadError) as exc: reader._build_outline_item( DictionaryObject( { NameObject("/Title"): TextStringObject("Toto"), NameObject("/Dest"): NumberObject(2), } ) ) assert "Unexpected destination 2" in exc.value.args[0] @pytest.mark.samples @pytest.mark.parametrize( ("src", "page_labels"), [ (RESOURCE_ROOT / "selenium-pypdf-issue-177.pdf", ["1"]), (RESOURCE_ROOT / "encrypted_doc_no_id.pdf", ["1", "2", "3"]), (RESOURCE_ROOT / "pdflatex-outline.pdf", ["1", "2", "3", "4"]), ( SAMPLE_ROOT / "009-pdflatex-geotopo/GeoTopo.pdf", ["i", "ii", "iii", "1", "2", "3"], ), ], ids=[ "selenium-pypdf-issue-177.pdf", "encrypted_doc_no_id.pdf", "pdflatex-outline.pdf", "GeoTopo.pdf", ], ) def test_page_labels(src, page_labels): max_indices = 6 assert PdfReader(src).page_labels[:max_indices] == page_labels[:max_indices] @pytest.mark.enable_socket def test_iss1559(): url = "https://github.com/py-pdf/pypdf/files/10441992/default.pdf" name = "iss1559.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) for p in reader.pages: p.extract_text() @pytest.mark.enable_socket def test_iss1652(): # test of an annotation(link) directly stored in the /Annots in the page url = "https://github.com/py-pdf/pypdf/files/10818844/tt.pdf" name = "invalidNamesDest.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.named_destinations @pytest.mark.enable_socket def test_iss1689(): url = "https://github.com/py-pdf/pypdf/files/10948283/error_file_without_data.pdf" name = "iss1689.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.pages[0] @pytest.mark.enable_socket def test_iss1710(): url = "https://github.com/py-pdf/pypdf/files/15234776/irbookonlinereading.pdf" name = "irbookonlinereading.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.outline def test_broken_file_header(): pdf_data = ( b"%%PDF-\xa0sd\n" b"1 0 obj << /Count 1 /Kids [4 0 R] /Type /Pages >> endobj\n" b"2 0 obj << >> endobj\n" b"3 0 obj << >> endobj\n" b"4 0 obj << /Contents 3 0 R /CropBox [0.0 0.0 2550.0 3508.0]" b" /MediaBox [0.0 0.0 2550.0 3508.0] /Parent 1 0 R" b" /Resources << /Font << >> >>" b" /Rotate 0 /Type /Page >> endobj\n" b"5 0 obj << /Pages 1 0 R /Type /Catalog >> endobj\n" b"xref 1 5\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"trailer << %s/Root 5 0 R /Size 6 >>\n" b"startxref %d\n" b"%%%%EOF" ) with_prev_0 = True pdf_data = pdf_data % ( pdf_data.find(b"1 0 obj"), pdf_data.find(b"2 0 obj"), pdf_data.find(b"3 0 obj"), pdf_data.find(b"4 0 obj"), pdf_data.find(b"5 0 obj"), b"/Prev 0 " if with_prev_0 else b"", pdf_data.find(b"xref") - 1, ) PdfReader(io.BytesIO(pdf_data)) @pytest.mark.enable_socket def test_iss1756(): url = "https://github.com/py-pdf/pypdf/files/11105591/641-Attachment-B-Pediatric-Cardiac-Arrest-8-1-2019.pdf" name = "iss1756.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.trailer["/ID"] # removed to cope with missing cryptodome during commit check : len(reader.pages) @pytest.mark.enable_socket @pytest.mark.timeout(30) def test_iss1825(): url = "https://github.com/py-pdf/pypdf/files/11367871/MiFO_LFO_FEIS_NOA_Published.3.pdf" name = "iss1825.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) page = reader.pages[0] page.extract_text() @pytest.mark.enable_socket def test_iss2082(): url = "https://github.com/py-pdf/pypdf/files/12317939/test.pdf" name = "iss2082.pdf" b = get_data_from_url(url, name=name) reader = PdfReader(BytesIO(b)) reader.pages[0].extract_text() bb = bytearray(b) bb[b.find(b"xref") + 2] = ord(b"E") with pytest.raises(PdfReadError): reader = PdfReader(BytesIO(bb)) @pytest.mark.enable_socket def test_issue_140(): url = "https://github.com/py-pdf/pypdf/files/12168578/bad_pdf_example.pdf" name = "issue-140.pdf" b = get_data_from_url(url, name=name) reader = PdfReader(BytesIO(b)) assert len(reader.pages) == 54 @pytest.mark.enable_socket def test_xyz_with_missing_param(): """Cf #2236""" url = "https://github.com/py-pdf/pypdf/files/12795356/tt1.pdf" name = "issue2236.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert reader.outline[0]["/Left"] == 820 assert reader.outline[0]["/Top"] == 0 assert reader.outline[1]["/Left"] == 0 assert reader.outline[0]["/Top"] == 0 @pytest.mark.enable_socket def test_corrupted_xref(): url = "https://github.com/py-pdf/pypdf/files/14628314/iss2516.pdf" name = "iss2516.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert reader.root_object["/Type"] == "/Catalog" @pytest.mark.enable_socket def test_truncated_xref(caplog): url = "https://github.com/py-pdf/pypdf/files/14843553/002-trivial-libre-office-writer-broken.pdf" name = "iss2575.pdf" PdfReader(BytesIO(get_data_from_url(url, name=name))) assert "Invalid/Truncated xref table. Rebuilding it." in caplog.text @pytest.mark.enable_socket def test_damaged_pdf(): url = "https://github.com/py-pdf/pypdf/files/15186107/malformed_pdf.pdf" name = "malformed_pdf.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name)), strict=False) len(reader.pages) strict_reader = PdfReader(BytesIO(get_data_from_url(url, name=name)), strict=True) with pytest.raises(PdfReadError) as exc: len(strict_reader.pages) assert ( exc.value.args[0] == "Expected object ID (21 0) does not match actual (-1 -1)." ) @pytest.mark.enable_socket @pytest.mark.timeout(10) def test_looping_form(caplog): """Cf iss 2643""" url = "https://github.com/py-pdf/pypdf/files/15306053/inheritance.pdf" name = "iss2643.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name)), strict=False) flds = reader.get_fields() assert all( x in flds for x in ( "Text10", "Text10.0.0.1.1.1.1.1.1.1.1.1.1.1.1.1.1.1", "amt1.0", "amt1.1", "DSS#3pg3#0hgu7", ) ) writer = PdfWriter(reader) writer.root_object["/AcroForm"]["/Fields"][5]["/Kids"].append( writer.root_object["/AcroForm"]["/Fields"][5]["/Kids"][0] ) flds2 = writer.get_fields() assert "Text68.0 already parsed" in caplog.text assert list(flds.keys()) == list(flds2.keys()) def test_context_manager_with_stream(): pdf_data = ( b"%%PDF-1.7\n" b"1 0 obj << /Count 1 /Kids [4 0 R] /Type /Pages >> endobj\n" b"2 0 obj << >> endobj\n" b"3 0 obj << >> endobj\n" b"4 0 obj << /Contents 3 0 R /CropBox [0.0 0.0 2550.0 3508.0]" b" /MediaBox [0.0 0.0 2550.0 3508.0] /Parent 1 0 R" b" /Resources << /Font << >> >>" b" /Rotate 0 /Type /Page >> endobj\n" b"5 0 obj << /Pages 1 0 R /Type /Catalog >> endobj\n" b"xref 1 5\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"trailer << /Root 5 0 R /Size 6 >>\n" b"startxref %d\n" b"%%%%EOF" ) pdf_data = pdf_data % ( pdf_data.find(b"1 0 obj"), pdf_data.find(b"2 0 obj"), pdf_data.find(b"3 0 obj"), pdf_data.find(b"4 0 obj"), pdf_data.find(b"5 0 obj"), pdf_data.find(b"xref") - 1, ) pdf_stream = io.BytesIO(pdf_data) with PdfReader(pdf_stream) as reader: assert not reader.stream.closed assert not pdf_stream.closed @pytest.mark.enable_socket @pytest.mark.timeout(10) def test_iss2761(): url = "https://github.com/user-attachments/files/16312198/crash-b26d05712a29b241ac6f9dc7fff57428ba2d1a04.pdf" name = "iss2761.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name)), strict=False) with pytest.raises(PdfReadError): reader.pages[0].extract_text() @pytest.mark.enable_socket def test_iss2817(): """Test for rebuiling Xref_ObjStm""" url = "https://github.com/user-attachments/files/16764070/crash-7e1356f1179b4198337f282304cb611aea26a199.pdf" name = "iss2817.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert ( reader.pages[0]["/Annots"][0].get_object()["/Contents"] == "A\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0 B" ) @pytest.mark.enable_socket def test_truncated_files(caplog): """Cf #2853""" url = "https://github.com/user-attachments/files/16796095/f5471sm-2.pdf" name = "iss2780.pdf" # reused b = get_data_from_url(url, name=name) reader = PdfReader(BytesIO(b)) assert caplog.text == "" # remove \n at end of file : invisible reader = PdfReader(BytesIO(b[:-1])) assert caplog.text == "" # truncate but still detectable for i in range(-2, -6, -1): caplog.clear() reader = PdfReader(BytesIO(b[:i])) assert "EOF marker seems truncated" in caplog.text assert reader._startxref == 100993 # remove completely EOF : we will not read last section caplog.clear() reader = PdfReader(BytesIO(b[:-6])) assert "CAUTION: startxref found while searching for %%EOF" in caplog.text assert reader._startxref < 100993 @pytest.mark.enable_socket def test_comments_in_array(caplog): """Cf #2843: this deals with comments""" url = "https://github.com/user-attachments/files/16992416/crash-2347912aa2a6f0fab5df4ebc8a424735d5d0d128.pdf" name = "iss2843.pdf" # reused b = get_data_from_url(url, name=name) reader = PdfReader(BytesIO(b)) reader.pages[0] assert caplog.text == "" reader = PdfReader(BytesIO(b)) reader.stream = BytesIO(b[:1149]) with pytest.raises(PdfStreamError): reader.pages[0] @pytest.mark.enable_socket def test_space_in_names_to_continue_processing(caplog): """ This deals with space not encoded in names inducing errors. Also covers case where NameObject not met for key. """ url = "https://github.com/user-attachments/files/17095516/crash-e108c4f677040b61e12fa9f1cfde025d704c9b0d.pdf" name = "iss2866.pdf" # reused b = get_data_from_url(url, name=name) reader = PdfReader(BytesIO(b)) obj = reader.get_object(70) assert all( x in obj for x in ( "/BaseFont", "/DescendantFonts", "/Encoding", "/Subtype", "/ToUnicode", "/Type", ) ) assert obj["/BaseFont"] == "/AASGAA+Arial,Unicode" # MS is missing to meet spec assert 'PdfReadError("Invalid Elementary Object starting with' in caplog.text caplog.clear() b = b[:264] + b"(Inv) /d " + b[273:] reader = PdfReader(BytesIO(b)) obj = reader.get_object(70) assert all( x in obj for x in ["/DescendantFonts", "/Encoding", "/Subtype", "/ToUnicode", "/Type"] ) assert all( x in caplog.text for x in ( "Expecting a NameObject for key but", 'PdfReadError("Invalid Elementary Object starting with', ) ) reader = PdfReader(BytesIO(b), strict=True) with pytest.raises(PdfReadError): obj = reader.get_object(70) @pytest.mark.enable_socket def test_unbalanced_brackets_in_dictionary_object(caplog): """Cf #2877""" url = "https://github.com/user-attachments/files/17162634/7f40cb209fb97d1782bffcefc5e7be40.pdf" name = "iss2877.pdf" # reused reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert len(reader.pages) == 43 # note: /Count = 46 but 3 kids are None @pytest.mark.enable_socket def test_repair_root(caplog): """Cf #2877""" url = "https://github.com/user-attachments/files/17162216/crash-6620e8b1abfe3da639b654595da859b87f985748.pdf" name = "iss2875.pdf" b = get_data_from_url(url, name=name) reader = PdfReader(BytesIO(b)) assert len(reader.pages) == 1 assert all( msg in caplog.text for msg in ( "Invalid Root object", 'Searching object with "/Catalog" key', "Root found at IndirectObject(2, 0,", ) ) # no /Root Entry reader = PdfReader(BytesIO(b.replace(b"/Root", b"/Roo "))) caplog.clear() assert len(reader.pages) == 1 assert all( msg in caplog.text for msg in ( 'Cannot find "/Root" key in trailer', 'Searching object with "/Catalog" key', "Root found at IndirectObject(2, 0,", ) ) # Invalid /Root Entry caplog.clear() reader = PdfReader( BytesIO( b.replace(b"/Root 1 0 R", b"/Root 2 0 R").replace(b"/Catalog/Pages 3 0 R", b"/Catalo ") ) ) with pytest.raises(PdfReadError): len(reader.pages) assert all( msg in caplog.text for msg in ( "Invalid Root object in trailer", 'Searching object with "/Catalog" key', ) ) # Invalid /Root Entry + error in get_object caplog.clear() data = b.replace(b"/Root 1 0 R", b"/Root 2 0 R").replace(b"/Catalog/Pages 3 0 R", b"/Catalo ") data = data[:5124] + b"A" + data[5125:] reader = PdfReader(BytesIO(data)) with pytest.raises(PdfReadError): len(reader.pages) assert all( msg in caplog.text for msg in ( "Invalid Root object in trailer", 'Searching object with "/Catalog" key', ) ) # Invalid /Root Entry without /Type, but /Pages. caplog.clear() reader = PdfReader( BytesIO( b.replace(b"/Root 1 0 R", b"/Root 2 0 R").replace(b"/Catalog", b"/Catalo ") ) ) assert len(reader.pages) == 1 assert all( msg in caplog.text for msg in ( "Invalid Root object in trailer", 'Searching object with "/Catalog" key', f"Possible root found at IndirectObject(2, 0, {id(reader)}), but missing /Catalog key" ) ) @pytest.mark.enable_socket def test_issue3151(caplog): """Tests for #3151""" url = "https://github.com/user-attachments/files/18941494/bible.pdf" name = "issue3151.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert len(reader.pages) == 742 @pytest.mark.enable_socket def test_issue2886(caplog): """Tests for #2886""" url = "https://github.com/user-attachments/files/17187711/crash-e8a85d82de01cab5eb44e7993304d8b9d1544970.pdf" name = "issue2886.pdf" with pytest.raises(PdfReadError, match=r"Unexpected empty line in Xref table\."): _ = PdfReader(BytesIO(get_data_from_url(url, name=name))) @pytest.mark.enable_socket def test_infinite_loop_for_length_value(): """Tests for #3112""" url = "https://github.com/user-attachments/files/19106009/Special.n.15.du.jeudi.22.fevrier.2024.pdf" name = "issue3112.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() with pytest.raises(PdfReadError, match=r"^Detected loop with self reference for IndirectObject\(165, 0, \d+\)\.$"): writer.add_page(reader.pages[0]) def test_trailer_cannot_be_read(): path = RESOURCE_ROOT / "crazyones.pdf" data = path.read_bytes().replace(b"/Type/XRef", b"/Type/Invalid") with pytest.raises(PdfReadError, match=r"^Trailer cannot be read: Unexpected type '/Invalid'$"): reader = PdfReader(BytesIO(data)) list(reader.pages) @pytest.mark.enable_socket def test_read_pdf15_xref_stream(): data = get_data_from_url(name="issue-3429.pdf") with pytest.raises(PdfReadError, match=r"^Trailer cannot be read: Size missing from XRef stream {"): PdfReader(BytesIO(data)) data_modified = data.replace(b"/XRef/", b"/XRef/Size/2/") with pytest.raises( PdfReadError, match=r"^Trailer cannot be read: Limit reached while decompressing\. 1545392 bytes remaining\.$" ): PdfReader(BytesIO(data_modified)) @pytest.mark.enable_socket def test_read_standard_xref_table__two_whitespace_characters_between_offset_and_generation(): """Tests for #3482""" url = "https://github.com/user-attachments/files/22591813/helloworld.pdf" name = "issue3482.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert len(reader.pages) == 1 assert reader.pages[0].extract_text() == "Hello World!" pypdf-6.1.2/tests/test_text_extraction.py000066400000000000000000000437711507516550200206630ustar00rootroot00000000000000""" Testing the text-extraction submodule and ensuring the quality of text extraction. The tested code might be in _page.py. """ import re from io import BytesIO from pathlib import Path from unittest.mock import patch import pytest from pypdf import PdfReader, mult from pypdf._text_extraction import set_custom_rtl from pypdf._text_extraction._layout_mode._fixed_width_page import text_show_operations from pypdf.errors import ParseError, PdfReadError from pypdf.generic import ContentStream from . import get_data_from_url TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" SAMPLE_ROOT = PROJECT_ROOT / "sample-files" @pytest.mark.samples @pytest.mark.parametrize(("visitor_text"), [None, lambda a, b, c, d, e: None]) # noqa: ARG005 def test_multi_language(visitor_text): reader = PdfReader(RESOURCE_ROOT / "multilang.pdf") txt = reader.pages[0].extract_text(visitor_text=visitor_text) assert "Hello World" in txt, "English not correctly extracted" # iss #1296 assert "مرحبا بالعالم" in txt, "Arabic not correctly extracted" assert "Привет, мир" in txt, "Russian not correctly extracted" assert "你好世界" in txt, "Chinese not correctly extracted" assert "สวัสดีชาวโลŕ¸" in txt, "Thai not correctly extracted" assert "ă“ă‚“ă«ăˇăŻä¸–ç•Ś" in txt, "Japanese not correctly extracted" # check customizations set_custom_rtl(None, None, "Russian:") assert ":naissuR" in reader.pages[0].extract_text( visitor_text=visitor_text ), "(1) CUSTOM_RTL_SPECIAL_CHARS failed" set_custom_rtl(None, None, [ord(x) for x in "Russian:"]) assert ":naissuR" in reader.pages[0].extract_text( visitor_text=visitor_text ), "(2) CUSTOM_RTL_SPECIAL_CHARS failed" set_custom_rtl(0, 255, None) assert ":hsilgnE" in reader.pages[0].extract_text( visitor_text=visitor_text ), "CUSTOM_RTL_MIN/MAX failed" set_custom_rtl("A", "z", []) assert ":hsilgnE" in reader.pages[0].extract_text( visitor_text=visitor_text ), "CUSTOM_RTL_MIN/MAX failed" set_custom_rtl(-1, -1, []) # to prevent further errors reader = PdfReader(SAMPLE_ROOT / "015-arabic/habibi-rotated.pdf") assert "habibi" in reader.pages[0].extract_text(visitor_text=visitor_text) assert "حَبيبي" in reader.pages[0].extract_text(visitor_text=visitor_text) assert "habibi" in reader.pages[1].extract_text(visitor_text=visitor_text) assert "حَبيبي" in reader.pages[1].extract_text(visitor_text=visitor_text) assert "habibi" in reader.pages[2].extract_text(visitor_text=visitor_text) assert "حَبيبي" in reader.pages[2].extract_text(visitor_text=visitor_text) assert "habibi" in reader.pages[3].extract_text(visitor_text=visitor_text) assert "حَبيبي" in reader.pages[3].extract_text(visitor_text=visitor_text) @pytest.mark.parametrize( ("file_name", "constraints"), [ ( "inkscape-abc.pdf", { "A": lambda x, y: 0 < x < 94 and 189 < y < 283, # In upper left "B": lambda x, y: 94 < x < 189 and 94 < y < 189, # In the center "C": lambda x, y: 189 < x < 283 and 0 < y < 94, # In lower right }, ) ], ) def test_visitor_text_matrices(file_name, constraints): """ Checks if the matrices given to the visitor_text function when calling `extract_text` on the first page of `file_name` match some given constraints. `constraints` is a dictionary mapping a line of text to a constraint that should evaluate to `True` on its expected x,y-coordinates. """ reader = PdfReader(RESOURCE_ROOT / file_name) lines = [] def visitor_text(text, cm, tm, font_dict, font_size) -> None: ctm = mult(tm, cm) x = ctm[4] # mult(tm, cm)[4] y = ctm[5] # mult(tm, cm)[5] lines.append({"text": text, "x": x, "y": y}) reader.pages[0].extract_text(visitor_text=visitor_text) for text, constraint in constraints.items(): matches = [li for li in lines if li["text"].strip() == text] assert len(matches) <= 1, f"Multiple lines match {text}" assert len(matches) >= 1, f"No lines match {text}" x = matches[0]["x"] y = matches[0]["y"] assert constraint(x, y), f'Line "{text}" is wrong at x:{x}, y:{y}' @pytest.mark.xfail(reason="known whitespace issue #2336") @pytest.mark.enable_socket def test_issue_2336(): name = "Pesquisa-de-Precos-Combustiveis-novembro-2023.pdf" reader = PdfReader(BytesIO(get_data_from_url(name=name))) page = reader.pages[0] actual_text = page.extract_text() assert "Beira Rio" in actual_text def test_layout_mode_font_class_to_dict(): from pypdf._text_extraction._layout_mode._font import Font # noqa: PLC0415 font = Font("foo", space_width=8, encoding="utf-8", char_map={}, font_dictionary={}) assert Font.to_dict(font) == { "char_map": {}, "encoding": "utf-8", "font_dictionary": {}, "space_width": 8, "subtype": "foo", "width_map": {}, "interpretable": True, } @pytest.mark.enable_socket @patch("pypdf._text_extraction._layout_mode._fixed_width_page.logger_warning") def test_uninterpretable_type3_font(mock_logger_warning): url = "https://github.com/user-attachments/files/18551904/UninterpretableType3Font.pdf" name = "UninterpretableType3Font.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) page = reader.pages[0] assert page.extract_text(extraction_mode="layout") == "" mock_logger_warning.assert_called_with( "PDF contains an uninterpretable font. Output will be incomplete.", "pypdf._text_extraction._layout_mode._fixed_width_page" ) @pytest.mark.enable_socket def test_layout_mode_epic_page_fonts(): url = "https://github.com/py-pdf/pypdf/files/13836944/Epic.Page.PDF" name = "Epic Page.PDF" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) expected = (RESOURCE_ROOT / "Epic.Page.layout.txt").read_text(encoding="utf-8") assert expected == reader.pages[0].extract_text(extraction_mode="layout") def test_layout_mode_uncommon_operators(): # Coverage for layout mode Tc, Tz, Ts, ', ", TD, TL, and Tw reader = PdfReader(RESOURCE_ROOT / "toy.pdf") expected = (RESOURCE_ROOT / "toy.layout.txt").read_text(encoding="utf-8") assert expected == reader.pages[0].extract_text(extraction_mode="layout") @pytest.mark.enable_socket def test_layout_mode_type0_font_widths(): # Cover both the 'int int int' and 'int [int int ...]' formats for Type0 # /DescendantFonts /W array entries. url = "https://github.com/py-pdf/pypdf/files/13533204/Claim.Maker.Alerts.Guide_pg2.PDF" name = "Claim Maker Alerts Guide_pg2.PDF" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) expected = (RESOURCE_ROOT / "Claim Maker Alerts Guide_pg2.layout.txt").read_text( encoding="utf-8" ) assert expected == reader.pages[0].extract_text(extraction_mode="layout") @pytest.mark.enable_socket def test_layout_mode_indirect_sequence_font_widths(): # Cover the situation where the sequence for font widths is an IndirectObject # https://github.com/py-pdf/pypdf/pull/2788 url = "https://github.com/user-attachments/files/16491621/2788_example.pdf" name = "2788_example.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert reader.pages[0].extract_text(extraction_mode="layout") == "" url = "https://github.com/user-attachments/files/16491619/2788_example_malformed.pdf" name = "2788_example_malformed.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) with pytest.raises(ParseError) as exc: reader.pages[0].extract_text(extraction_mode="layout") assert str(exc.value).startswith("Invalid font width definition") def dummy_visitor_text(text, ctm, tm, fd, fs): pass @patch("pypdf._page.logger_warning") def test_layout_mode_warnings(mock_logger_warning): # Check that a warning is issued when an argument is ignored reader = PdfReader(RESOURCE_ROOT / "hello-world.pdf") page = reader.pages[0] page.extract_text(extraction_mode="plain", visitor_text=dummy_visitor_text) mock_logger_warning.assert_not_called() page.extract_text(extraction_mode="layout", visitor_text=dummy_visitor_text) mock_logger_warning.assert_called_with( "Argument visitor_text is ignored in layout mode", "pypdf._page" ) @pytest.mark.enable_socket def test_space_with_one_unit_smaller_than_font_width(): """Tests for #1328""" url = "https://github.com/py-pdf/pypdf/files/9498481/0004.pdf" name = "iss1328.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) page = reader.pages[0] extracted = page.extract_text() assert "Reporting crude oil leak.\n" in extracted @pytest.mark.enable_socket def test_space_position_calculation(): """Tests for #1153""" url = "https://github.com/py-pdf/pypdf/files/9164743/file-0.pdf" name = "iss1153.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) page = reader.pages[3] extracted = page.extract_text() assert "Shortly after the Geneva BOF session, the" in extracted def test_text_leading_height_unit(): """Tests for #2262""" reader = PdfReader(RESOURCE_ROOT / "toy.pdf") page = reader.pages[0] extracted = page.extract_text() assert "Something[cited]\n" in extracted def test_layout_mode_space_vertically_font_height_weight(): """Tests layout mode with vertical space and font height weight (issue #2915)""" with open(RESOURCE_ROOT / "crazyones.pdf", "rb") as inputfile: # Load PDF file from file reader = PdfReader(inputfile) page = reader.pages[0] # Normal behaviour with open(RESOURCE_ROOT / "crazyones_layout_vertical_space.txt", "rb") as pdftext_file: pdftext = pdftext_file.read() text = page.extract_text(extraction_mode="layout", layout_mode_space_vertically=True).encode("utf-8") # Compare the text of the PDF to a known source for expected_line, actual_line in zip(text.splitlines(), pdftext.splitlines()): assert expected_line == actual_line pdftext = pdftext.replace(b"\r\n", b"\n") # fix for windows assert text == pdftext # Blank lines are added to truly separate paragraphs with open(RESOURCE_ROOT / "crazyones_layout_vertical_space_font_height_weight.txt", "rb") as pdftext_file: pdftext = pdftext_file.read() text = page.extract_text(extraction_mode="layout", layout_mode_space_vertically=True, layout_mode_font_height_weight=0.85).encode("utf-8") # Compare the text of the PDF to a known source for expected_line, actual_line in zip(text.splitlines(), pdftext.splitlines()): assert expected_line == actual_line pdftext = pdftext.replace(b"\r\n", b"\n") # fix for windows assert text == pdftext @pytest.mark.enable_socket def test_infinite_loop_arrays(): """Tests for #2928""" url = "https://github.com/user-attachments/files/17576546/arrayabruptending.pdf" name = "arrayabruptending.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) page = reader.pages[0] extracted = page.extract_text() assert "RNA structure comparison" in extracted @pytest.mark.enable_socket def test_content_stream_is_dictionary_object(caplog): """Tests for #2995""" url = "https://github.com/user-attachments/files/18049322/6fa5fd46-5f98-4a67-800d-5e2362b0164f.pdf" name = "iss2995.pdf" data = get_data_from_url(url, name=name) reader = PdfReader(BytesIO(data)) page = reader.pages[0] assert "\nYours faithfully \n" in page.extract_text() assert "Expected StreamObject, got DictionaryObject instead. Data might be wrong." in caplog.text caplog.clear() reader = PdfReader(BytesIO(data), strict=True) page = reader.pages[0] with pytest.raises(PdfReadError) as exception: page.extract_text() assert ( "Invalid Elementary Object starting with b\\'\\\\x18\\' @3557: b\\'ateDecode/Length 629\\\\x18ck[" in exception.value.args[0] ) @pytest.mark.enable_socket def test_tz_with_no_operands(): """Tests for #2975""" url = "https://github.com/user-attachments/files/17974120/9E5E080E-C8DB-4A6B-822B-9A67DC04E526-120438.pdf" name = "iss2975.pdf" data = get_data_from_url(url, name=name) reader = PdfReader(BytesIO(data)) page = reader.pages[1] assert "\nThankyouforyourattentiontothismatter.\n" in page.extract_text() @pytest.mark.enable_socket def test_iss3060(): """Test for not throwing 'font not set: is PDF missing a Tf operator'""" url = "https://github.com/user-attachments/files/18482531/test-anon.pdf" name = "iss3060.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) # pypdf.errors.PdfReadError: font not set: is PDF missing a Tf operator? txt = reader.pages[0].extract_text(extraction_mode="layout") assert txt.startswith(" *******") @pytest.mark.enable_socket def test_iss3074(): """Test for not throwing 'ZeroDivisionError: float division by zero'""" url = "https://github.com/user-attachments/files/18533211/test-anon.pdf" name = "iss3074.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) # pypdf.errors.PdfReadError: ZeroDivisionError: float division by zero txt = reader.pages[0].extract_text(extraction_mode="layout") assert txt.strip().startswith("AAAAAA") @pytest.mark.enable_socket def test_layout_mode_text_state(): """Ensure the text state is stored and reset with q/Q operators.""" # Get the PDF from issue #3212 url = "https://github.com/user-attachments/files/19396790/garbled.pdf" name = "garbled-font.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) # Get the txt from issue #3212 and normalize line endings txt_url = "https://github.com/user-attachments/files/19510731/garbled-font.layout.txt" txt_name = "garbled-font.layout.txt" expected = get_data_from_url(txt_url, name=txt_name).decode("utf-8").replace("\r\n", "\n") assert expected == reader.pages[0].extract_text(extraction_mode="layout") @pytest.mark.enable_socket def test_rotated_line_wrap(): """Ensure correct 2D translation of rotated text after a line wrap.""" # Get the PDF from issue #3247 url = "https://github.com/user-attachments/files/19696918/link16-line-wrap.sanitized.pdf" name = "link16-line-wrap.sanitized.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) # Get the txt from issue #3247 and normalize line endings txt_url = "https://github.com/user-attachments/files/19696917/link16-line-wrap.sanitized.expected.txt" txt_name = "link16-line-wrap.sanitized.expected.txt" expected = get_data_from_url(txt_url, name=txt_name).decode("utf-8").replace("\r\n", "\n") assert expected == reader.pages[0].extract_text() @pytest.mark.parametrize( ("op", "msg"), [ (b"BT", "Unbalanced target operations, expected b'ET'."), (b"q", "Unbalanced target operations, expected b'Q'."), ], ) def test_layout_mode_warns_on_malformed_content_stream(op, msg, caplog): """Ensures that imbalanced q/Q or EB/ET is handled gracefully.""" text_show_operations(ops=iter([([], op)]), fonts={}) assert caplog.records assert caplog.records[-1].msg == msg def test_process_operation__cm_multiplication_issue(): """Test for #3262.""" reader = PdfReader(RESOURCE_ROOT / "crazyones.pdf") page = reader.pages[0] content = page.get_contents().get_data() content = content.replace(b" 1 0 0 1 72 720 cm ", b" 0.70278 65.3 163.36 cm ") stream = ContentStream(stream=None, pdf=reader) stream.set_data(content) page.replace_contents(stream) assert page.extract_text().startswith("The Crazy Ones\nOctober 14, 1998\n") @pytest.mark.enable_socket def test_rotated_layout_mode(caplog): """Ensures text extraction of rotated pages, as in issue #3270.""" url = "https://github.com/user-attachments/files/19981120/rotated-page.pdf" name = "rotated-page.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) page = reader.pages[0] page.transfer_rotation_to_content() text = page.extract_text(extraction_mode="layout") assert not caplog.records, "No warnings should be issued" assert text, "Text matching the page rotation should be extracted" assert re.search(r"\r?\n +69\r?\n +UNCLASSIFIED$", text), "Contents should be in expected layout" @pytest.mark.enable_socket @pytest.mark.filterwarnings("ignore::pypdf.errors.PdfReadWarning") def test_extract_text__none_objects(): url = "https://github.com/user-attachments/files/18381726/tika-957721.pdf" name = "tika-957721.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader.pages[0].extract_text() reader.pages[8].extract_text() @pytest.mark.enable_socket def test_extract_text__with_visitor_text(): def visitor_text(*args, **kwargs): # noqa: ANN002, ANN003, ANN202 pass url = "https://github.com/user-attachments/files/18381718/tika-952016.pdf" name = "tika-952016.pdf" stream = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(stream) page = reader.pages[0] page.extract_text(visitor_text=visitor_text) reader = PdfReader(BytesIO(get_data_from_url(name="TextAttack_paper.pdf"))) page = reader.pages[0] page.extract_text(visitor_text=visitor_text) @pytest.mark.enable_socket def test_extract_text__restore_cm_stack_pop_error(): url = "https://github.com/user-attachments/files/18381737/tika-966635.pdf" name = "tika-966635.pdf" stream = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(stream) page = reader.pages[10] # There is a previous error we already omit ("pop from empty list"), thus # check for the message explicitly here. with pytest.raises(IndexError, match="list index out of range"): page.extract_text() pypdf-6.1.2/tests/test_utils.py000066400000000000000000000357161507516550200165770ustar00rootroot00000000000000"""Test the pypdf._utils module.""" import functools import io import re import subprocess import sys from datetime import datetime, timedelta, timezone from pathlib import Path from typing import Any, Callable import pytest import pypdf._utils from pypdf._utils import ( File, Version, _get_max_pdf_version_header, _human_readable_bytes, check_if_whitespace_only, classproperty, deprecate_with_replacement, deprecation_no_replacement, format_iso8824_date, mark_location, matrix_multiply, parse_iso8824_date, read_block_backwards, read_previous_line, read_until_regex, read_until_whitespace, rename_kwargs, skip_over_comment, skip_over_whitespace, ) from pypdf.errors import DeprecationError, PdfReadError, PdfStreamError from . import is_sublist TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" @pytest.mark.parametrize( ("stream", "expected"), [ (io.BytesIO(b"foo"), False), (io.BytesIO(b""), False), (io.BytesIO(b" "), True), (io.BytesIO(b" "), True), (io.BytesIO(b" \n"), True), (io.BytesIO(b" \n"), True), (io.BytesIO(b"\f"), True), ], ) def test_skip_over_whitespace(stream, expected): assert skip_over_whitespace(stream) == expected @pytest.mark.parametrize( ("value", "expected"), [ (b"foo", False), (b" a", False), (b" a\n b", False), (b"", True), (b" ", True), (b" ", True), (b" \n", True), (b" \n", True), (b"\f", True), ], ) def test_check_if_whitespace_only(value, expected): assert check_if_whitespace_only(value) is expected def test_read_until_whitespace(): assert read_until_whitespace(io.BytesIO(b"foo"), maxchars=1) == b"f" @pytest.mark.parametrize( ("stream", "remainder"), [ (io.BytesIO(b"% foobar\n"), b""), (io.BytesIO(b""), b""), (io.BytesIO(b" "), b" "), (io.BytesIO(b"% foo%\nbar"), b"bar"), ], ) def test_skip_over_comment(stream, remainder): skip_over_comment(stream) assert stream.read() == remainder def test_read_until_regex_premature_ending_name(): stream = io.BytesIO(b"") assert read_until_regex(stream, re.compile(b".")) == b"" @pytest.mark.parametrize( ("a", "b", "expected"), [ (((3,),), ((7,),), ((21,),)), (((3, 7),), ((5,), (13,)), ((3 * 5.0 + 7 * 13,),)), (((3,), (7,)), ((5, 13),), ((3 * 5, 3 * 13), (7 * 5, 7 * 13))), ], ) def test_matrix_multiply(a, b, expected): assert matrix_multiply(a, b) == expected def test_mark_location(): stream = io.BytesIO(b"abde" * 6000) mark_location(stream) Path("pypdf_pdfLocation.txt").unlink() # cleanup def test_deprecate_no_replacement(): with pytest.warns( expected_warning=DeprecationWarning, match="foo is deprecated and will be removed in pypdf 3.0.0." ): pypdf._utils.deprecate_no_replacement("foo", removed_in="3.0.0") @pytest.mark.parametrize( ("dat", "pos", "to_read", "expected", "expected_pos"), [ (b"abc", 1, 0, b"", 1), (b"abc", 1, 1, b"a", 0), (b"abc", 2, 1, b"b", 1), (b"abc", 2, 2, b"ab", 0), (b"abc", 3, 1, b"c", 2), (b"abc", 3, 2, b"bc", 1), (b"abc", 3, 3, b"abc", 0), (b"", 0, 1, None, 0), (b"a", 0, 1, None, 0), (b"abc", 0, 10, None, 0), ], ) def test_read_block_backwards(dat, pos, to_read, expected, expected_pos): s = io.BytesIO(dat) s.seek(pos) if expected is not None: assert read_block_backwards(s, to_read) == expected else: with pytest.raises(PdfStreamError): read_block_backwards(s, to_read) assert s.tell() == expected_pos def test_read_block_backwards_at_start(): s = io.BytesIO(b"abc") with pytest.raises(PdfStreamError) as _: read_previous_line(s) @pytest.mark.parametrize( ("dat", "pos", "expected", "expected_pos"), [ (b"abc", 1, b"a", 0), (b"abc", 2, b"ab", 0), (b"abc", 3, b"abc", 0), (b"abc\n", 3, b"abc", 0), (b"abc\n", 4, b"", 3), (b"abc\n\r", 4, b"", 3), (b"abc\nd", 5, b"d", 3), # Skip over multiple CR/LF bytes (b"abc\n\r\ndef", 9, b"def", 3), ], ids=list(range(8)), ) def test_read_previous_line(dat, pos, expected, expected_pos): s = io.BytesIO(dat) s.seek(pos) assert read_previous_line(s) == expected assert s.tell() == expected_pos # for unknown reason if the parameters are passed through pytest, errors are reported def test_read_previous_line2(): # Include a block full of newlines... test_read_previous_line( b"abc" + b"\n" * (2 * io.DEFAULT_BUFFER_SIZE) + b"d", 2 * io.DEFAULT_BUFFER_SIZE + 4, b"d", 3, ) # Include a block full of non-newline characters test_read_previous_line( b"abc\n" + b"d" * (2 * io.DEFAULT_BUFFER_SIZE), 2 * io.DEFAULT_BUFFER_SIZE + 4, b"d" * (2 * io.DEFAULT_BUFFER_SIZE), 3, ) # Both test_read_previous_line( b"abcxyz" + b"\n" * (2 * io.DEFAULT_BUFFER_SIZE) + b"d" * (2 * io.DEFAULT_BUFFER_SIZE), 4 * io.DEFAULT_BUFFER_SIZE + 6, b"d" * (2 * io.DEFAULT_BUFFER_SIZE), 6, ) def test_get_max_pdf_version_header(): with pytest.raises(ValueError) as exc: _get_max_pdf_version_header(b"", b"PDF-1.2") assert exc.value.args[0] == "Neither b'' nor b'PDF-1.2' are proper headers" def test_read_block_backwards_exception(): stream = io.BytesIO(b"foobar") stream.seek(6) with pytest.raises(PdfReadError) as exc: read_block_backwards(stream, 7) assert exc.value.args[0] == "Could not read malformed PDF file" def test_deprecate_with_replacement(): def foo() -> None: deprecate_with_replacement("foo", "bar", removed_in="4.3.2") with pytest.warns( DeprecationWarning, match="foo is deprecated and will be removed in pypdf 4.3.2. Use bar instead.", ): foo() def test_deprecation_no_replacement(): def foo() -> None: deprecation_no_replacement("foo", removed_in="4.3.2") with pytest.raises( DeprecationError, match=r"foo is deprecated and was removed in pypdf 4\.3\.2\.", ): foo() def test_rename_kwargs(): def deprecation_bookmark_nofail(**aliases: str) -> Callable: """ Decorator for deprecated term "bookmark". To be used for methods and function arguments outline_item = a bookmark outline = a collection of outline items. """ def decoration(func: Callable) -> Any: # type: ignore @functools.wraps(func) def wrapper(*args: Any, **kwargs: Any) -> Any: # type: ignore rename_kwargs(func.__name__, kwargs, aliases, fail=False) return func(*args, **kwargs) return wrapper return decoration @deprecation_bookmark_nofail(old_param="new_param") def foo(old_param: int = 1, baz: int = 2, new_param: int = 1) -> None: pass expected_msg = ( "foo received both old_param and new_param as an argument. " "old_param is deprecated. Use new_param instead." ) with pytest.raises(TypeError, match=expected_msg): foo(old_param=12, new_param=13) with pytest.warns( DeprecationWarning, match="old_param is deprecated as an argument. Use new_param instead", ): foo(old_param=12) def test_rename_kwargs__stacklevel(tmp_path: Path) -> None: script = tmp_path / "script.py" script.write_text(""" import functools import warnings from pypdf._utils import rename_kwargs def deprecation(**aliases: str): def decoration(func): @functools.wraps(func) def wrapper(*args, **kwargs): rename_kwargs(func.__name__, kwargs, aliases, fail=False) return func(*args, **kwargs) return wrapper return decoration @deprecation(old_param="new_param") def foo(old_param: int = 1, baz: int = 2, new_param: int = 1) -> None: pass warnings.simplefilter("always") foo(old_param=12) """) result = subprocess.run([sys.executable, script], capture_output=True, text=True) # noqa: S603 assert result.returncode == 0 assert result.stderr == ( f"{script}:23: DeprecationWarning: old_param is deprecated as an argument. " f"Use new_param instead\n foo(old_param=12)\n" ) @pytest.mark.parametrize( ("input_int", "expected_output"), [ (123, "123 Byte"), (1234, "1.2 kB"), (123_456, "123.5 kB"), (1_234_567, "1.2 MB"), (1_234_567_890, "1.2 GB"), (1_234_567_890_000, "1234.6 GB"), ], ) def test_human_readable_bytes(input_int, expected_output): """_human_readable_bytes correctly transforms the integer to a string.""" assert _human_readable_bytes(input_int) == expected_output def test_file_class(): """File class can be instantiated and string representation is ok.""" f = File(name="image.png", data=b"") assert str(f) == "File(name=image.png, data: 0 Byte)" assert repr(f) == "File(name=image.png, data: 0 Byte, hash: 0)" @pytest.mark.parametrize( ("text", "expected"), [ ("D:20210318000756", "2021-03-18T00:07:56"), ("20210318000756", "2021-03-18T00:07:56"), ("D:2021", "2021-01-01T00:00:00"), ("D:202103", "2021-03-01T00:00:00"), ("D:20210304", "2021-03-04T00:00:00"), ("D:2021030402", "2021-03-04T02:00:00"), ("D:20210408054711", "2021-04-08T05:47:11"), ("D:20210408054711Z", "2021-04-08T05:47:11+00:00"), ("D:20210408054711Z00", "2021-04-08T05:47:11+00:00"), ("D:20210408054711Z0000", "2021-04-08T05:47:11+00:00"), ("D:20210408075331+02'00'", "2021-04-08T07:53:31+02:00"), ("D:20210408075331-03'00'", "2021-04-08T07:53:31-03:00"), ], ) def test_parse_datetime(text, expected): date = parse_iso8824_date(text) date_str = (date.isoformat() + date.strftime("%z"))[: len(expected)] assert date_str == expected @pytest.mark.parametrize( ("text", "expected"), [ ("", None), (None, None), ], ) def test_parse_datetime_edge_cases(text, expected): date = parse_iso8824_date(text) assert date == expected def test_parse_datetime_err(): with pytest.raises(ValueError) as ex: parse_iso8824_date("D:20210408T054711Z") assert ex.value.args[0] == "Can not convert date: D:20210408T054711Z" assert parse_iso8824_date("D:20210408054711").tzinfo is None def test_format_iso8824_date(): """Test format_iso8824_date function with timezone handling.""" dt_naive = datetime(2021, 3, 18, 12, 7, 56) result = format_iso8824_date(dt_naive) assert result == "D:20210318120756" dt_utc = datetime(2021, 3, 18, 12, 7, 56, tzinfo=timezone.utc) result = format_iso8824_date(dt_utc) assert result == "D:20210318120756+00'00'" dt_positive = datetime(2021, 3, 18, 12, 7, 56, tzinfo=timezone(timedelta(hours=2, minutes=30))) result = format_iso8824_date(dt_positive) assert result == "D:20210318120756+02'30'" dt_negative = datetime(2021, 3, 18, 12, 7, 56, tzinfo=timezone(timedelta(hours=-5, minutes=-30))) result = format_iso8824_date(dt_negative) assert result == "D:20210318120756-05'30'" def test_format_iso8824_date_roundtrip(): dt_naive = datetime(2021, 3, 18, 12, 7, 56) formatted = format_iso8824_date(dt_naive) parsed = parse_iso8824_date(formatted) assert parsed == dt_naive dt_utc = datetime(2021, 3, 18, 12, 7, 56, tzinfo=timezone.utc) formatted = format_iso8824_date(dt_utc) parsed = parse_iso8824_date(formatted) assert parsed == dt_utc dt_positive = datetime(2021, 3, 18, 12, 7, 56, tzinfo=timezone(timedelta(hours=2, minutes=30))) formatted = format_iso8824_date(dt_positive) parsed = parse_iso8824_date(formatted) assert parsed == dt_positive dt_negative = datetime(2021, 3, 18, 12, 7, 56, tzinfo=timezone(timedelta(hours=-5, minutes=-30))) formatted = format_iso8824_date(dt_negative) parsed = parse_iso8824_date(formatted) assert parsed == dt_negative def test_is_sublist(): # Basic checks: assert is_sublist([0, 1], [0, 1, 2]) is True assert is_sublist([0, 2], [0, 1, 2]) is True assert is_sublist([1, 2], [0, 1, 2]) is True assert is_sublist([0, 3], [0, 1, 2]) is False # Ensure order is checked: assert is_sublist([1, 0], [0, 1, 2]) is False # Ensure duplicates are handled: assert is_sublist([0, 1, 1], [0, 1, 1, 2]) is True assert is_sublist([0, 1, 1], [0, 1, 2]) is False # Edge cases with empty lists: assert is_sublist([], [0, 1, 2]) is True assert is_sublist([0, 1], []) is False # Self-sublist edge case: assert is_sublist([0, 1, 2], [0, 1, 2]) is True @pytest.mark.parametrize( ("left", "right", "is_less_than"), [ ("1", "2", True), ("2", "1", False), ("1", "1", False), ("1.0", "1.1", True), ("1", "1.1", True), # Suffix left ("1a", "2", True), ("2a", "1", False), ("1a", "1", False), ("1.0a", "1.1", True), # I'm not sure about that, but seems special enough that it # probably doesn't matter: ("1a", "1.1", False), # Suffix right ("1", "2a", True), ("2", "1a", False), ("1", "1a", True), ("1.0", "1.1a", True), ("1", "1.1a", True), ("", "0.0.0", True), # Just suffix matters ... hm, I think this is actually wrong: ("1.0a", "1.0", False), ("1.0", "1.0a", True), ], ) def test_version_compare(left, right, is_less_than): assert (Version(left) < Version(right)) is is_less_than def test_version_compare_equal_str(): a = Version("1.0") assert a != "1.0" def test_version_compare_lt_str(): a = Version("1.0") with pytest.raises(ValueError) as exc: a < "1.0" # noqa: B015 assert exc.value.args[0] == "Version cannot be compared against " def test_bad_version(): assert Version("a").components == [(0, "a")] def test_version_eq_hash(): version1 = Version("1.0") version2 = Version("1.0") version3 = Version("1.1") assert version1 == version2 assert version1 != version3 assert hash(version1) == hash(version2) assert hash(version1) != hash(version3) def test_classproperty(): class Container: @classproperty def value1(cls) -> int: # noqa: N805 return 42 @classproperty def value2(cls) -> int: # noqa: N805 return 1337 @classproperty def value3(cls) -> int: # noqa: N805 return 1 @value3.getter def value3(cls) -> int: # noqa: N805 return 2 assert Container.value1 == 42 assert Container.value2 == 1337 assert Container.value3 == 2 assert Container().value1 == 42 assert Container().value2 == 1337 assert Container().value3 == 2 pypdf-6.1.2/tests/test_workflows.py000066400000000000000000001226021507516550200174630ustar00rootroot00000000000000""" Tests in this module behave like user code. They don't mock/patch anything, they cover typical user needs. """ import binascii import sys from io import BytesIO from pathlib import Path from re import findall import pytest from PIL import Image, ImageChops from PIL import __version__ as pil_version from pypdf import PdfReader, PdfWriter, Transformation from pypdf.constants import PageAttributes as PG from pypdf.errors import PdfReadError, PdfReadWarning from pypdf.generic import ( ArrayObject, ContentStream, DictionaryObject, NameObject, TextStringObject, read_object, ) from . import PILContext, get_data_from_url, normalize_warnings TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" SAMPLE_ROOT = PROJECT_ROOT / "sample-files" sys.path.append(str(PROJECT_ROOT)) def test_basic_features(tmp_path): pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) writer = PdfWriter() assert len(reader.pages) == 1 # add page 1 from input1 to output document, unchanged writer.add_page(reader.pages[0]) # add page 2 from input1, but rotated clockwise 90 degrees writer.add_page(reader.pages[0].rotate(90)) # add page 3 from input1, but first add a watermark from another PDF: page3 = reader.pages[0] watermark_pdf = pdf_path watermark = PdfReader(watermark_pdf) page3.merge_page(watermark.pages[0]) writer.add_page(page3) # add page 4 from input1, but crop it to half size: page4 = reader.pages[0] page4.mediabox.upper_right = ( page4.mediabox.right / 2, page4.mediabox.top / 2, ) del page4.mediabox writer.add_page(page4) # add some Javascript to launch the print window on opening this PDF. # the password dialog may prevent the print dialog from being shown, # comment the encryption lines, if that's the case, to try this out writer.add_js("this.print({bUI:true,bSilent:false,bShrinkToFit:true});") # encrypt your new PDF and add a password password = "secret" writer.encrypt(password) # doing it twice should not change anything writer.encrypt(password) # finally, write "output" to pypdf-output.pdf write_path = tmp_path / "pypdf-output.pdf" with open(write_path, "wb") as output_stream: writer.write(output_stream) def test_dropdown_items(): inputfile = RESOURCE_ROOT / "libreoffice-form.pdf" reader = PdfReader(inputfile) fields = reader.get_fields() assert "/Opt" in fields["Nationality"] def test_pdfreader_file_load(): """ Test loading and parsing of a file. Extract text of the file and compare to expected textual output. Expected outcome: file loads, text matches expected. """ with open(RESOURCE_ROOT / "crazyones.pdf", "rb") as inputfile: # Load PDF file from file reader = PdfReader(inputfile) page = reader.pages[0] # Retrieve the text of the PDF with open(RESOURCE_ROOT / "crazyones.txt", "rb") as pdftext_file: pdftext = pdftext_file.read() text = page.extract_text().encode("utf-8") # Compare the text of the PDF to a known source for expected_line, actual_line in zip(text.splitlines(), pdftext.splitlines()): assert expected_line == actual_line pdftext = pdftext.replace(b"\r\n", b"\n") # fix for windows assert text == pdftext def test_pdfreader_jpeg_image(): """ Test loading and parsing of a file. Extract the image of the file and compare to expected textual output. Expected outcome: file loads, image matches expected. """ with open(RESOURCE_ROOT / "jpeg.pdf", "rb") as inputfile: # Load PDF file from file reader = PdfReader(inputfile) # Retrieve the text of the image with open(RESOURCE_ROOT / "jpeg.txt") as pdftext_file: imagetext = pdftext_file.read() page = reader.pages[0] x_object = page[PG.RESOURCES]["/XObject"].get_object() data = x_object["/Im4"].get_data() # Compare the text of the PDF to a known source assert binascii.hexlify(data).decode() == imagetext def test_decrypt(): with open(RESOURCE_ROOT / "libreoffice-writer-password.pdf", "rb") as inputfile: reader = PdfReader(inputfile) assert reader.is_encrypted is True reader.decrypt("openpassword") assert len(reader.pages) == 1 assert reader.is_encrypted is True metadict = reader.metadata assert dict(metadict) == { "/CreationDate": "D:20220403203552+02'00'", "/Creator": "Writer", "/Producer": "LibreOffice 6.4", } def test_text_extraction_encrypted(): inputfile = RESOURCE_ROOT / "libreoffice-writer-password.pdf" reader = PdfReader(inputfile) assert reader.is_encrypted is True reader.decrypt("openpassword") assert ( reader.pages[0] .extract_text() .strip() .startswith("Lorem ipsum dolor sit amet") ) @pytest.mark.parametrize("degree", [0, 90, 180, 270, 360, -90]) def test_rotate(degree): with open(RESOURCE_ROOT / "crazyones.pdf", "rb") as inputfile: reader = PdfReader(inputfile) page = reader.pages[0] page.rotate(degree) def test_rotate_45(): with open(RESOURCE_ROOT / "crazyones.pdf", "rb") as inputfile: reader = PdfReader(inputfile) page = reader.pages[0] with pytest.raises(ValueError) as exc: page.rotate(45) assert exc.value.args[0] == "Rotation angle must be a multiple of 90" @pytest.mark.enable_socket @pytest.mark.slow @pytest.mark.parametrize( ("enable", "url", "pages"), [ (True, "https://arxiv.org/pdf/2201.00214.pdf", [0, 1, 5, 10]), ( True, "https://github.com/py-pdf/sample-files/raw/main/009-pdflatex-geotopo/GeoTopo.pdf", [0, 1, 5, 10], ), (True, "https://arxiv.org/pdf/2201.00151.pdf", [0, 1, 5, 10]), (True, "https://arxiv.org/pdf/1707.09725.pdf", [0, 1, 5, 10]), (True, "https://arxiv.org/pdf/2201.00021.pdf", [0, 1, 5, 8]), (True, "https://arxiv.org/pdf/2201.00037.pdf", [0, 1, 5, 10]), (True, "https://arxiv.org/pdf/2201.00069.pdf", [0, 1, 5, 10]), (True, "https://arxiv.org/pdf/2201.00178.pdf", [0, 1, 5, 10]), (True, "https://arxiv.org/pdf/2201.00201.pdf", [0, 1, 5, 8]), (True, "https://arxiv.org/pdf/1602.06541.pdf", [0, 1, 5, 10]), (True, "https://arxiv.org/pdf/2201.00200.pdf", [0, 1, 5, 6]), (True, "https://arxiv.org/pdf/2201.00022.pdf", [0, 1, 5, 10]), (True, "https://arxiv.org/pdf/2201.00029.pdf", [0, 1, 6, 10]), # #1145 (True, "https://github.com/py-pdf/pypdf/files/9174594/2017.pdf", [0]), # #1145, remaining issue (empty arguments for FlateEncoding) ( True, "https://github.com/py-pdf/pypdf/files/9175966/2015._pb_decode_pg0.pdf", [0], ), # 6 instead of 5: as there is an issue in page 5 (missing objects) # and too complex to handle the warning without hiding real regressions (True, "https://arxiv.org/pdf/1601.03642.pdf", [0, 1, 5, 7]), ( True, "https://github.com/py-pdf/pypdf/files/3796761/17343_2008_Order_09-Jan-2019.pdf", [0, 1], ), ( True, "https://github.com/py-pdf/pypdf/files/8884471/ssi_manwaring.pdf", [0, 1], ), (True, "https://github.com/py-pdf/pypdf/files/8884469/999092.pdf", [0, 1]), ( True, "file://" + str(RESOURCE_ROOT / "test Orient.pdf"), [0], ), # TODO: preparation of text orientation validation ( True, "https://github.com/py-pdf/pypdf/files/8884470/fdocuments.in_sweet-fundamentals-of-crystallography.pdf", [0, 1, 34, 35, 36, 118, 119, 120, 121], ), (True, "https://github.com/py-pdf/pypdf/files/8884493/998167.pdf", [0]), ( True, "https://github.com/user-attachments/files/18382039/971703.pdf", [0, 1, 5, 8, 14], ), ( # faulty PDF, wrongly linearized and with 2 trailer, second with /Root True, "https://github.com/user-attachments/files/18382034/989691.pdf", [0], ), ], ) def test_extract_textbench(enable, url, pages): if not enable: return print_result = False try: reader = PdfReader(BytesIO(get_data_from_url(url, url.split("/")[-1]))) for page_number in pages: if print_result: print(f"**************** {url} / page {page_number} ****************") rst = reader.pages[page_number].extract_text() if print_result: print(f"{rst}\n*****************************\n") except PdfReadWarning: pass def test_transform_compress_identical_objects(): reader = PdfReader(RESOURCE_ROOT / "two-different-pages.pdf") writer = PdfWriter() for page in reader.pages: op = Transformation().scale(sx=0.8, sy=0.8) page.add_transformation(op) writer.add_page(page) writer.compress_identical_objects() bytes_out = BytesIO() writer.write(bytes_out) result_reader = PdfReader(bytes_out) pg1_text = result_reader.pages[0].extract_text() pg2_text = result_reader.pages[1].extract_text() assert pg1_text.strip() == "1" assert pg2_text.strip() == "2" @pytest.mark.slow def test_orientations(): p = PdfReader(RESOURCE_ROOT / "test Orient.pdf").pages[0] p.extract_text("", "") p.extract_text("", "", 0) p.extract_text("", "", 0, 200) p.extract_text() assert findall("\\((.)\\)", p.extract_text()) == ["T", "B", "L", "R"] with pytest.raises(Exception): p.extract_text(None) p.extract_text("", 0) with pytest.raises(Exception): p.extract_text("", "", None) with pytest.raises(Exception): p.extract_text("", "", 0, "") with pytest.raises(Exception): p.extract_text(0, "") p.extract_text(0, 0) p.extract_text(orientations=0) for req, rst in ( (0, ["T"]), (90, ["L"]), (180, ["B"]), (270, ["R"]), ((0,), ["T"]), ((0, 180), ["T", "B"]), ((45,), []), ): assert ( findall("\\((.)\\)", p.extract_text(req)) == rst ), f"extract_text({req}) => {rst}" @pytest.mark.samples @pytest.mark.enable_socket @pytest.mark.parametrize( ("base_path", "overlay_path"), [ ( "resources/crazyones.pdf", "sample-files/013-reportlab-overlay/reportlab-overlay.pdf", ), ( "https://github.com/user-attachments/files/18381707/tika-935981.pdf", "sample-files/013-reportlab-overlay/reportlab-overlay.pdf", ), ], ) def test_overlay(pdf_file_path, base_path, overlay_path): if base_path.startswith("http"): base_path = BytesIO(get_data_from_url(base_path, name="tika-935981.pdf")) else: base_path = PROJECT_ROOT / base_path reader = PdfReader(base_path) writer = PdfWriter() reader_overlay = PdfReader(PROJECT_ROOT / overlay_path) overlay = reader_overlay.pages[0] for page in reader.pages: page.merge_page(overlay) writer.add_page(page) with open(pdf_file_path, "wb") as fp: writer.write(fp) @pytest.mark.enable_socket @pytest.mark.slow @pytest.mark.parametrize( ("url", "name"), [ ( "https://github.com/user-attachments/files/18381697/tika-924546.pdf", "tika-924546.pdf", ) ], ) @pytest.mark.filterwarnings("ignore::DeprecationWarning") def test_merge_with_warning(tmp_path, url, name): data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data) merger = PdfWriter() merger.append(reader) # This could actually be a performance bottleneck: merger.write(tmp_path / "tmp.merged.pdf") @pytest.mark.enable_socket @pytest.mark.parametrize( ("url", "name"), [ ( "https://github.com/user-attachments/files/18381757/tika-980613.pdf", "tika-980613.pdf", ) ], ) @pytest.mark.filterwarnings("ignore::DeprecationWarning") def test_merge(tmp_path, url, name): data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data) merger = PdfWriter() merger.append(reader) merger.write(tmp_path / "tmp.merged.pdf") @pytest.mark.enable_socket @pytest.mark.parametrize( ("url", "name", "expected_metadata"), [ ( "https://github.com/user-attachments/files/18381708/tika-935996.pdf", "tika-935996.pdf", { "/Author": "Unknown", "/CreationDate": "Thursday, May 06, 1999 3:56:54 PM", "/Creator": r"C:\DEB\6338", "/Keywords": "", "/Producer": "Acrobat PDFWriter 3.02 for Windows", "/Subject": "", "/Title": r"C:\DEB\6338-6R.PDF", }, ) ], ) def test_get_metadata(url, name, expected_metadata): data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data) data = reader.metadata assert expected_metadata == data @pytest.mark.enable_socket @pytest.mark.parametrize( ("url", "name", "strict", "exception"), [ ( "https://github.com/user-attachments/files/16624503/tika-938702.pdf", "tika-938702.pdf", False, None, # iss #1090 is now fixed ), ( "https://github.com/user-attachments/files/18381715/tika-942358.pdf", "tika-942358.pdf", False, None, ), ( "https://github.com/user-attachments/files/18381684/tika-911260.pdf", "tika-911260.pdf", False, None, ), ( "https://github.com/user-attachments/files/18381766/tika-992472.pdf", "tika-992472.pdf", False, None, ), ( "https://github.com/user-attachments/files/18381756/tika-978477.pdf", "tika-978477.pdf", False, None, ), ( "https://github.com/user-attachments/files/18381731/tika-960317.pdf", "tika-960317.pdf", False, None, ), ( "https://github.com/user-attachments/files/18381701/tika-930513.pdf", "tika-930513.pdf", False, None, ), ( "https://github.com/user-attachments/files/18381691/tika-918113.pdf", "tika-918113.pdf", True, None, ), ( "https://github.com/user-attachments/files/18381711/tika-940704.pdf", "tika-940704.pdf", True, None, ), ( "https://github.com/user-attachments/files/18381752/tika-976488.pdf", "tika-976488.pdf", True, None, ), ( "https://github.com/user-attachments/files/18381716/tika-948176.pdf", "tika-948176.pdf", True, None, ), ], ) def test_extract_text(url, name, strict, exception): data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data, strict=strict) if not exception: for page in reader.pages: page.extract_text() else: exc, exc_text = exception with pytest.raises(exc) as ex_info: for page in reader.pages: page.extract_text() assert ex_info.value.args[0] == exc_text @pytest.mark.enable_socket @pytest.mark.parametrize( ("url", "name"), [ ( "https://github.com/user-attachments/files/18381710/tika-938702.pdf", "tika-938702.pdf", ), ( "https://github.com/user-attachments/files/18381725/tika-957304.pdf", "tika-957304.pdf", ), ( "https://github.com/user-attachments/files/18381690/tika-915194.pdf", "tika-915194.pdf", ), ( "https://github.com/user-attachments/files/18381717/tika-950337.pdf", "tika-950337.pdf", ), ( "https://github.com/user-attachments/files/18381734/tika-962292.pdf", "tika-962292.pdf", ), ], ) def test_compress_raised(url, name): data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data) writer = PdfWriter() writer.clone_document_from_reader(reader) # no more error since iss #1090 fix for page in writer.pages: page.compress_content_streams() @pytest.mark.enable_socket @pytest.mark.parametrize( ("url", "name"), [ ( "https://github.com/user-attachments/files/18381733/tika-961883.pdf", "tika-961883.pdf", ), ], ) def test_get_fields_warns(tmp_path, caplog, url, name): data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data) write_path = tmp_path / "tmp.txt" with open(write_path, "w") as fp: retrieved_fields = reader.get_fields(fileobj=fp) assert retrieved_fields == {} assert normalize_warnings(caplog.text) == [ "Ignoring wrong pointing object 1 65536 (offset 0)", "Ignoring wrong pointing object 2 65536 (offset 0)", "Object 2 0 not defined.", ] @pytest.mark.enable_socket @pytest.mark.parametrize( ("url", "name"), [ ( "https://github.com/user-attachments/files/18381713/tika-942050.pdf", "tika-942050.pdf", ), ], ) def test_get_fields_no_warning(tmp_path, url, name): data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data) write_path = tmp_path / "tmp.txt" with open(write_path, "w") as fp: retrieved_fields = reader.get_fields(fileobj=fp) assert len(retrieved_fields) == 10 @pytest.mark.enable_socket def test_scale_rectangle_indirect_object(): url = "https://github.com/user-attachments/files/18381778/tika-999944.pdf" name = "tika-999944.pdf" data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data) for page in reader.pages: page.scale(sx=2, sy=3) def test_merge_output(caplog): # Arrange base = RESOURCE_ROOT / "Seige_of_Vicksburg_Sample_OCR.pdf" crazy = RESOURCE_ROOT / "crazyones.pdf" expected = RESOURCE_ROOT / "Seige_of_Vicksburg_Sample_OCR-crazyones-merged.pdf" # Act merger = PdfWriter() merger.append(base) merger.merge(1, crazy) stream = BytesIO() merger.write(stream) # Assert stream.seek(0) actual = stream.read() with open(expected, "rb") as fp: expected_data = fp.read() if actual != expected_data: # See https://github.com/pytest-dev/pytest/issues/9124 pytest.fail( f"len(actual) = {len(actual):,} vs len(expected) = {len(expected_data):,}" ) # Cleanup merger.close() @pytest.mark.enable_socket @pytest.mark.parametrize( ("url", "name"), [ ( "https://github.com/user-attachments/files/18381767/tika-994636.pdf", "tika-994636.pdf", ), ( "https://github.com/user-attachments/files/18381719/tika-952133.pdf", "tika-952133.pdf", ), ( # JPXDecode "https://github.com/user-attachments/files/18381688/tika-914568.pdf", "tika-914568.pdf", ), ( "https://github.com/user-attachments/files/18381718/tika-952016.pdf", "tika-952016.pdf", ), ( "https://github.com/user-attachments/files/18382223/965118.pdf", "tika-965118.pdf", ), ( "https://github.com/user-attachments/files/18381729/tika-959184.pdf", "tika-959184.pdf", ), ( "https://github.com/user-attachments/files/18381727/tika-958496.pdf", "tika-958496.pdf", ), ( "https://github.com/user-attachments/files/18381744/tika-972174.pdf", "tika-972174.pdf", ), ( "https://github.com/user-attachments/files/18381745/tika-972243.pdf", "tika-972243.pdf", ), ( "https://github.com/user-attachments/files/18381743/tika-969502.pdf", "tika-969502.pdf", ), ("https://arxiv.org/pdf/2201.00214.pdf", "arxiv-2201.00214.pdf"), ], ) def test_image_extraction(url, name): data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data) images_extracted = [] root = Path("extracted-images") if not root.exists(): root.mkdir() with PILContext(): for page in reader.pages: for image in page.images: filename = root / image.name with open(filename, "wb") as img: img.write(image.data) images_extracted.append(filename) # Cleanup do_cleanup = True # set this to False for manual inspection if do_cleanup: for filepath in images_extracted: if Path(filepath).exists(): Path(filepath).unlink() @pytest.mark.enable_socket def test_image_extraction_strict(): # Emits log messages url = "https://github.com/user-attachments/files/18381687/tika-914102.pdf" name = "tika-914102.pdf" data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data, strict=True) images_extracted = [] root = Path("extracted-images") if not root.exists(): root.mkdir() for page in reader.pages: for image in page.images: filename = root / image.name with open(filename, "wb") as fp: fp.write(image.data) images_extracted.append(filename) # Cleanup do_cleanup = True # set this to False for manual inspection if do_cleanup: for filepath in images_extracted: if Path(filepath).exists(): Path(filepath).unlink() @pytest.mark.enable_socket @pytest.mark.parametrize( ("url", "name"), [ ( "https://github.com/user-attachments/files/18381754/tika-977609.pdf", "tika-977609.pdf", ), ], ) def test_image_extraction2(url, name): data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data) images_extracted = [] root = Path("extracted-images") if not root.exists(): root.mkdir() for page in reader.pages: for image in page.images: filename = root / image.name with open(filename, "wb") as img: img.write(image.data) images_extracted.append(filename) # Cleanup do_cleanup = True # set this to False for manual inspection if do_cleanup: for filepath in images_extracted: if Path(filepath).exists(): Path(filepath).unlink() @pytest.mark.enable_socket @pytest.mark.parametrize( ("url", "name"), [ ( "https://github.com/user-attachments/files/18381692/tika-918137.pdf", "tika-918137.pdf", ), ( "https://github.com/user-attachments/files/22596566/7552c42e9280b4476e59e77acc0bc812.pdf", "7552c42e9280b4476e59e77acc0bc812.pdf", ), ], ) def test_get_outline(url, name): data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data) reader.outline @pytest.mark.enable_socket @pytest.mark.parametrize( ("url", "name"), [ ( "https://github.com/user-attachments/files/18381707/tika-935981.pdf", "tika-935981.pdf", ), ( "https://github.com/user-attachments/files/18381709/tika-937334.pdf", "tika-937334.pdf", ), ], ) def test_get_xfa(url, name): data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data) reader.xfa @pytest.mark.enable_socket @pytest.mark.parametrize( ("url", "name", "strict"), [ ( "https://github.com/user-attachments/files/18381765/tika-988698.pdf", "tika-988698.pdf", False, ), ( "https://github.com/user-attachments/files/18382162/914133.pdf", "tika-914133.pdf", False, ), ( "https://github.com/user-attachments/files/18381685/tika-912552.pdf", "tika-912552.pdf", False, ), ( "https://github.com/user-attachments/files/18381687/tika-914102.pdf", "tika-914102.pdf", True, ), ], ) def test_get_fonts(url, name, strict): data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data, strict=strict) for page in reader.pages: page._get_fonts() @pytest.mark.enable_socket @pytest.mark.parametrize( ("url", "name", "strict"), [ ( "https://github.com/user-attachments/files/18382060/tika-942303.pdf", "tika-942303.pdf", True, ), ( "https://github.com/user-attachments/files/18381707/tika-935981.pdf", "tika-935981.pdf", True, ), ( "https://github.com/user-attachments/files/18381738/tika-967399.pdf", "tika-967399.pdf", True, ), ( "https://github.com/user-attachments/files/18381707/tika-935981.pdf", "tika-935981.pdf", False, ), ], ) def test_get_xmp(url, name, strict): data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data, strict=strict) xmp_info = reader.xmp_metadata if xmp_info: xmp_info.dc_contributor xmp_info.dc_coverage xmp_info.dc_creator xmp_info.dc_date xmp_info.dc_description xmp_info.dc_format xmp_info.dc_identifier xmp_info.dc_language xmp_info.dc_publisher xmp_info.dc_relation xmp_info.dc_rights xmp_info.dc_source xmp_info.dc_subject xmp_info.dc_title xmp_info.dc_type xmp_info.pdf_keywords xmp_info.pdf_pdfversion xmp_info.pdf_producer xmp_info.xmp_create_date xmp_info.xmp_modify_date xmp_info.xmp_metadata_date xmp_info.xmp_creator_tool xmp_info.xmpmm_document_id xmp_info.xmpmm_instance_id xmp_info.custom_properties @pytest.mark.enable_socket def test_tounicode_is_identity(): url = "https://github.com/py-pdf/pypdf/files/9998335/FP_Thesis.pdf" name = "FP_Thesis.pdf" data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data, strict=False) reader.pages[0].extract_text() @pytest.mark.enable_socket def test_append_forms(): # from #1538 writer = PdfWriter() url = "https://github.com/py-pdf/pypdf/files/10367412/pdfa.pdf" name = "form_a.pdf" reader1 = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader1.add_form_topname("form_a") writer.append(reader1) url = "https://github.com/py-pdf/pypdf/files/10367413/pdfb.pdf" name = "form_b.pdf" reader2 = PdfReader(BytesIO(get_data_from_url(url, name=name))) reader2.add_form_topname("form_b") writer.append(reader2) b = BytesIO() writer.write(b) reader = PdfReader(b) assert len(reader.get_form_text_fields()) == len( reader1.get_form_text_fields() ) + len(reader2.get_form_text_fields()) @pytest.mark.enable_socket def test_extra_test_iss1541(): url = "https://github.com/py-pdf/pypdf/files/10418158/tst_iss1541.pdf" name = "tst_iss1541.pdf" data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data, strict=False) reader.pages[0].extract_text() cs = ContentStream(reader.pages[0]["/Contents"], None, None) cs.operations.insert(-1, ([], b"EMC")) stream = BytesIO() cs.write_to_stream(stream) stream.seek(0) ContentStream(read_object(stream, None, None), None, None).operations cs = ContentStream(reader.pages[0]["/Contents"], None, None) cs.operations.insert(-1, ([], b"E!C")) stream = BytesIO() cs.write_to_stream(stream) stream.seek(0) ContentStream(read_object(stream, None, None), None, None).operations b = BytesIO(data.getbuffer()) reader = PdfReader( BytesIO(bytes(b.getbuffer()).replace(b"EI \n", b"E! \n")), strict=False ) with pytest.raises(PdfReadError) as exc: reader.pages[0].extract_text() assert exc.value.args[0] == "Unexpected end of stream" @pytest.mark.enable_socket def test_fields_returning_stream(): """This problem was reported in #424""" url = "https://github.com/mstamy2/PyPDF2/files/1948267/Simple.form.pdf" name = "tst_iss424.pdf" data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(data, strict=False) assert "BtchIssQATit_time" in reader.get_form_text_fields()["TimeStampData"] def test_replace_image(tmp_path): writer = PdfWriter(clone_from=RESOURCE_ROOT / "labeled-edges-center-image.pdf") reader = PdfReader(RESOURCE_ROOT / "jpeg.pdf") img = reader.pages[0].images[0].image if int(pil_version.split(".")[0]) < 9: img = img.convert("RGB") writer.pages[0].images[0].replace(img) b = BytesIO() writer.write(b) reader2 = PdfReader(b) if int(pil_version.split(".")[0]) >= 9: assert reader2.pages[0].images[0].image.mode == "RGBA" # very simple image distance evaluation diff = ImageChops.difference(reader2.pages[0].images[0].image, img) d = sum(diff.convert("L").getdata()) / (diff.size[0] * diff.size[1]) assert d < 1.5 img = img.convert("RGB") # quality does not apply to RGBA/JP2 writer.pages[0].images[0].replace(img, quality=20) diff = ImageChops.difference(writer.pages[0].images[0].image, img) d1 = sum(diff.convert("L").getdata()) / (diff.size[0] * diff.size[1]) assert d1 > d # extra tests for coverage with pytest.raises(TypeError) as exc: reader.pages[0].images[0].replace(img) assert exc.value.args[0] == "Cannot update an image not belonging to a PdfWriter." i = writer.pages[0].images[0] with pytest.raises(TypeError) as exc: i.replace(reader.pages[0].images[0]) # missing .image assert exc.value.args[0] == "new_image shall be a PIL Image" i.indirect_reference = None # to behave like an inline image with pytest.raises(TypeError) as exc: i.replace(reader.pages[0].images[0].image) assert exc.value.args[0] == "Cannot update an inline image." import pypdf # noqa: PLC0415 try: pypdf._page.pil_not_imported = True with pytest.raises(ImportError) as exc: i.replace(reader.pages[0].images[0].image) finally: pypdf._page.pil_not_imported = False @pytest.mark.enable_socket def test_inline_images(): """This problem was reported in #424""" url = "https://arxiv.org/pdf/2201.00151.pdf" name = "2201.00151.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) url = "https://github.com/py-pdf/pypdf/assets/4083478/28e8b87c-be2c-40d9-9c86-15c7819021bf" name = "inline4.png" img_ref = Image.open(BytesIO(get_data_from_url(url, name=name))) assert list(reader.pages[1].images[4].image.getdata()) == list(img_ref.getdata()) with pytest.raises(KeyError): reader.pages[0].images["~999~"] del reader.pages[1]["/Resources"]["/ColorSpace"]["/R124"] reader.pages[1].inline_images = None # to force recalculation with pytest.raises(PdfReadError): reader.pages[1].images["~1~"] co = reader.pages[0].get_contents() co.operations.append(([], b"BI")) reader.pages[0][NameObject("/Contents")] = co reader.pages[0].images.keys() with pytest.raises(TypeError) as exc: reader.pages[0].images[0].replace(img_ref) assert exc.value.args[0] == "Cannot update an inline image." _a = {} for x, y in reader.pages[2].images[0:-2].items(): _a[x] = y # noqa: PERF403 # Testing code and easier to read this way. with pytest.raises(KeyError) as exc: reader.pages[2]._get_image(("test",)) url = "https://github.com/py-pdf/pypdf/files/15233597/bug1065245.pdf" name = "iss2598c.pdf" # test data also used in test_images.py/test_inline_image_extraction() reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert len(reader.pages[0].images) == 3 @pytest.mark.enable_socket def test_issue1899(): url = "https://github.com/py-pdf/pypdf/files/11801077/lv2018tconv.pdf" name = "lv2018tconv.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) for i, page in enumerate(reader.pages): print(i) page.extract_text() @pytest.mark.enable_socket def test_cr_with_cm_operation(): """Issue #2138""" url = "https://github.com/py-pdf/pypdf/files/12483807/AEO.1172.pdf" name = "iss2138.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert ( """STATUS: FNL STYLE: 1172 1172 KNIT SHORTIE SUMMER-B 2023 Company: AMERICAN EAGLE OUTFITTERS Division / Dept: 50 / 170 Season: SUMMER-B 2023""" in reader.pages[0].extract_text() ) # currently there is still a white space on last line missing # so we can not do a full comparison. def remove_trailing_whitespace(text: str) -> str: text = text.strip() return "\n".join(line.rstrip() for line in text.splitlines()) @pytest.mark.samples @pytest.mark.parametrize( ("pdf_path", "expected_path"), [ ( SAMPLE_ROOT / "026-latex-multicolumn/multicolumn.pdf", RESOURCE_ROOT / "multicolumn-lorem-ipsum.txt", ), ( SAMPLE_ROOT / "010-pdflatex-forms/pdflatex-forms.pdf", RESOURCE_ROOT / "010-pdflatex-forms.txt", ), ], ) def test_text_extraction_layout_mode(pdf_path, expected_path): reader = PdfReader(pdf_path) actual = reader.pages[0].extract_text(extraction_mode="layout") expected = expected_path.read_text(encoding="utf-8") # We don't care about trailing whitespace assert remove_trailing_whitespace(actual) == remove_trailing_whitespace(expected) @pytest.mark.enable_socket def test_layout_mode_space_vertically(): reader = PdfReader(BytesIO(get_data_from_url(name="iss2138.pdf"))) # remove automatically added final newline expected = ( (RESOURCE_ROOT / "AEO.1172.layout.txt").read_text(encoding="utf-8").rstrip() ) assert expected == reader.pages[0].extract_text( extraction_mode="layout", layout_mode_space_vertically=False ) @pytest.mark.enable_socket @pytest.mark.parametrize( ("rotation", "strip_rotated"), [(90, True), (180, False), (270, True)] ) def test_layout_mode_rotations(rotation, strip_rotated): reader = PdfReader(BytesIO(get_data_from_url(name="iss2138.pdf"))) rotated_page = reader.pages[0].rotate(rotation) rotated_page.transfer_rotation_to_content() expected = "" if not strip_rotated: expected = ( (RESOURCE_ROOT / "AEO.1172.layout.rot180.txt") .read_text(encoding="utf-8") .rstrip() ) # remove automatically added final newline assert expected == rotated_page.extract_text( extraction_mode="layout", layout_mode_space_vertically=False, layout_mode_strip_rotated=strip_rotated, ) def test_text_extraction_invalid_mode(): pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) with pytest.raises(ValueError, match="Invalid text extraction mode"): reader.pages[0].extract_text(extraction_mode="foo") # type: ignore @pytest.mark.enable_socket def test_get_page_showing_field(): """ Uses testfile from #2452 in order to get fields on multiple pages, choices boxes,... """ url = "https://github.com/py-pdf/pypdf/files/14031491/Form_Structure_v50.pdf" name = "iss2452.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name))) writer = PdfWriter(clone_from=reader) # validate with Field: only works on Reader (no get_fields on writer yet) fld = reader.get_fields() assert [ p.page_number for p in reader.get_pages_showing_field(fld["FormVersion"]) ] == [0] # validate with dictionary object # NRCategory field is a radio box assert [ p.page_number for p in reader.get_pages_showing_field( reader.trailer["/Root"]["/AcroForm"]["/Fields"][8].get_object() ) ] == [0, 0, 0, 0, 0] assert [ p.page_number for p in writer.get_pages_showing_field( writer._root_object["/AcroForm"]["/Fields"][8].get_object() ) ] == [0, 0, 0, 0, 0] # validate with IndirectObject # SiteID field is a textbox on multiple pages assert [ p.page_number for p in reader.get_pages_showing_field( reader.trailer["/Root"]["/AcroForm"]["/Fields"][99] ) ] == [0, 1] assert [ p.page_number for p in writer.get_pages_showing_field( writer._root_object["/AcroForm"]["/Fields"][99] ) ] == [0, 1] # test directly on the widget: assert [ p.page_number for p in reader.get_pages_showing_field( reader.trailer["/Root"]["/AcroForm"]["/Fields"][99]["/Kids"][1] ) ] == [1] assert [ p.page_number for p in writer.get_pages_showing_field( writer._root_object["/AcroForm"]["/Fields"][99]["/Kids"][1] ) ] == [1] # Exceptions: # Invalid Object with pytest.raises(ValueError) as exc: reader.get_pages_showing_field(None) with pytest.raises(ValueError) as exc: writer.get_pages_showing_field(None) assert "Field type is invalid" in exc.value.args[0] # Damage Field del reader.trailer["/Root"]["/AcroForm"]["/Fields"][1].get_object()["/FT"] del writer._root_object["/AcroForm"]["/Fields"][1].get_object()["/FT"] with pytest.raises(ValueError) as exc: reader.get_pages_showing_field( reader.trailer["/Root"]["/AcroForm"]["/Fields"][1] ) with pytest.raises(ValueError) as exc: writer.get_pages_showing_field(writer._root_object["/AcroForm"]["/Fields"][1]) assert "Field is not valid" in exc.value.args[0] # missing Parent in field del reader.trailer["/Root"]["/AcroForm"]["/Fields"][99]["/Kids"][1].get_object()[ "/Parent" ] del writer._root_object["/AcroForm"]["/Fields"][99]["/Kids"][1].get_object()[ "/Parent" ] with pytest.raises(ValueError) as exc: reader.get_pages_showing_field( reader.trailer["/Root"]["/AcroForm"]["/Fields"][1] ) with pytest.raises(ValueError) as exc: writer.get_pages_showing_field(writer._root_object["/AcroForm"]["/Fields"][1]) # remove "/P" (optional) del reader.trailer["/Root"]["/AcroForm"]["/Fields"][8]["/Kids"][1].get_object()[ "/P" ] del writer._root_object["/AcroForm"]["/Fields"][8]["/Kids"][1].get_object()["/P"] assert [ p.page_number for p in reader.get_pages_showing_field( reader.trailer["/Root"]["/AcroForm"]["/Fields"][8]["/Kids"][1] ) ] == [0] assert [ p.page_number for p in writer.get_pages_showing_field( writer._root_object["/AcroForm"]["/Fields"][8]["/Kids"][1] ) ] == [0] assert [ p.page_number for p in reader.get_pages_showing_field( reader.trailer["/Root"]["/AcroForm"]["/Fields"][8].get_object() ) ] == [0, 0, 0, 0, 0] assert [ p.page_number for p in writer.get_pages_showing_field( writer._root_object["/AcroForm"]["/Fields"][8].get_object() ) ] == [0, 0, 0, 0, 0] # Grouping fields reader.trailer["/Root"]["/AcroForm"]["/Fields"][-1].get_object()[ NameObject("/Kids") ] = ArrayObject([reader.trailer["/Root"]["/AcroForm"]["/Fields"][0]]) del reader.trailer["/Root"]["/AcroForm"]["/Fields"][-1].get_object()["/T"] del reader.trailer["/Root"]["/AcroForm"]["/Fields"][-1].get_object()["/P"] del reader.trailer["/Root"]["/AcroForm"]["/Fields"][-1].get_object()["/Subtype"] writer._root_object["/AcroForm"]["/Fields"].append( writer._add_object( DictionaryObject( { NameObject("/T"): TextStringObject("grouping"), NameObject("/FT"): NameObject("/Tx"), NameObject("/Kids"): ArrayObject( [reader.trailer["/Root"]["/AcroForm"]["/Fields"][0]] ), } ) ) ) assert [ p.page_number for p in reader.get_pages_showing_field( reader.trailer["/Root"]["/AcroForm"]["/Fields"][-1] ) ] == [] assert [ p.page_number for p in writer.get_pages_showing_field( writer._root_object["/AcroForm"]["/Fields"][-1] ) ] == [] @pytest.mark.enable_socket def test_extract_empty_page(): """Cf #2533""" url = "https://github.com/py-pdf/pypdf/files/14718318/test.pdf" name = "iss2533.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name))) assert reader.pages[1].extract_text(extraction_mode="layout") == "" @pytest.mark.enable_socket def test_iss2815(): """Cf #2815""" url = "https://github.com/user-attachments/files/16760725/crash-c1920c7a064649e1191d7879952ec252473fc7e6.pdf" name = "iss2815.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name))) assert reader.pages[0].extract_text() == "test command with wrong number of args" pypdf-6.1.2/tests/test_writer.py000066400000000000000000002747441507516550200167610ustar00rootroot00000000000000"""Test the pypdf._writer module.""" import re import shutil import subprocess from io import BytesIO from pathlib import Path from tempfile import NamedTemporaryFile from typing import Any from unittest import mock import pytest from pypdf import ( ImageType, ObjectDeletionFlag, PageObject, PdfReader, PdfWriter, Transformation, ) from pypdf.annotations import Link from pypdf.errors import DeprecationError, PageSizeNotDefinedError, PdfReadError, PyPdfError from pypdf.generic import ( ArrayObject, ByteStringObject, ContentStream, DecodedStreamObject, Destination, DictionaryObject, Fit, IndirectObject, NameObject, NullObject, NumberObject, RectangleObject, StreamObject, TextStringObject, ) from . import get_data_from_url, is_sublist from .test_images import image_similarity TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" SAMPLE_ROOT = Path(PROJECT_ROOT) / "sample-files" GHOSTSCRIPT_BINARY = shutil.which("gs") def _get_write_target(convert) -> Any: target = convert if callable(convert): with NamedTemporaryFile(suffix=".pdf", delete=False) as temporary: target = temporary.name return target def test_writer_exception_non_binary(tmp_path, caplog): src = RESOURCE_ROOT / "pdflatex-outline.pdf" reader = PdfReader(src) writer = PdfWriter() writer.add_page(reader.pages[0]) with open(tmp_path / "out.txt", "w") as fp, pytest.raises(TypeError): writer.write_stream(fp) ending = "to write to is not in binary mode. It may not be written to correctly.\n" assert caplog.text.endswith(ending) def test_writer_clone(): src = RESOURCE_ROOT / "pdflatex-outline.pdf" reader = PdfReader(src) writer = PdfWriter(clone_from=reader) assert len(writer.pages) == 4 assert "PageObject" in str(type(writer.pages[0])) writer = PdfWriter(clone_from=src) assert len(writer.pages) == 4 assert "PageObject" in str(type(writer.pages[0])) def test_clone_metadata(): src = RESOURCE_ROOT / "pdflatex-outline.pdf" reader = PdfReader(src) writer = PdfWriter(clone_from=reader) writer.add_metadata({"/foo": "bar"}) assert writer.metadata == { **reader.metadata, "/foo": "bar", } writer = PdfWriter() writer.clone_document_from_reader(reader) writer.add_metadata({"/foo": "bar"}) assert writer.metadata == { **reader.metadata, "/foo": "bar", } writer.metadata = None writer.add_metadata({"/foo": "bar"}) assert writer.metadata == {"/foo": "bar"} writer = PdfWriter() writer.clone_reader_document_root(reader) writer.add_metadata({"/foo": "bar"}) assert writer.metadata == {"/foo": "bar"} def test_writer_clone_bookmarks(): # Arrange src = RESOURCE_ROOT / "Seige_of_Vicksburg_Sample_OCR-crazyones-merged.pdf" reader = PdfReader(src) writer = PdfWriter() # Act + test cat cat = "" def cat1(p) -> None: nonlocal cat cat += p.__repr__() writer.clone_document_from_reader(reader, cat1) assert "/Page" in cat assert writer.pages[0].raw_get("/Parent") == writer._pages writer.add_outline_item("Page 1", 0) writer.add_outline_item("Page 2", 1) # Assert bytes_stream = BytesIO() writer.write(bytes_stream) bytes_stream.seek(0) reader2 = PdfReader(bytes_stream) assert len(reader2.pages) == len(reader.pages) assert len(reader2.outline) == 2 # test with append writer = PdfWriter() writer.append(reader) writer.add_outline_item("Page 1", 0) writer.add_outline_item("Page 2", 1) # Assert bytes_stream = BytesIO() writer.write(bytes_stream) bytes_stream.seek(0) reader2 = PdfReader(bytes_stream) assert len(reader2.pages) == len(reader.pages) assert len(reader2.outline) == 2 def writer_operate(writer: PdfWriter) -> None: """ To test the writer that initialized by each of the four usages. Args: writer: A PdfWriter object """ pdf_path = RESOURCE_ROOT / "crazyones.pdf" pdf_outline_path = RESOURCE_ROOT / "pdflatex-outline.pdf" reader = PdfReader(pdf_path) reader_outline = PdfReader(pdf_outline_path) page = reader.pages[0] with pytest.raises(PageSizeNotDefinedError) as exc: writer.add_blank_page() assert exc.value.args == () writer.insert_page(page, 1) writer.insert_page(reader_outline.pages[0], 0) writer.add_outline_item_destination(page) writer.remove_links() writer.add_outline_item_destination(page) oi = writer.add_outline_item( "An outline item", 0, None, (255, 0, 15), True, True, Fit.fit_box_vertically(10) ) writer.add_outline_item( "The XYZ fit", 0, oi, (255, 0, 15), True, True, Fit.xyz(left=10, top=20, zoom=3) ) writer.add_outline_item( "The XYZ fit no args", 0, oi, (255, 0, 15), True, True, Fit.xyz() ) writer.add_outline_item( "The FitH fit", 0, oi, (255, 0, 15), True, True, Fit.fit_horizontally(top=10) ) writer.add_outline_item( "The FitV fit", 0, oi, (255, 0, 15), True, True, Fit.fit_vertically(left=10) ) writer.add_outline_item( "The FitR fit", 0, oi, (255, 0, 15), True, True, Fit.fit_rectangle(left=10, bottom=20, right=30, top=40), ) writer.add_outline_item( "The FitB fit", 0, oi, (255, 0, 15), True, True, Fit.fit_box() ) writer.add_outline_item( "The FitBH fit", 0, oi, (255, 0, 15), True, True, Fit.fit_box_horizontally(top=10), ) writer.add_outline_item( "The FitBV fit", 0, oi, (255, 0, 15), True, True, Fit.fit_box_vertically(left=10), ) writer.add_blank_page() writer.add_uri(2, "https://example.com", RectangleObject([0, 0, 100, 100])) writer.add_uri(2, "https://example.com", RectangleObject([0, 0, 100, 100])) writer.add_annotation( page_number=2, annotation=Link(target_page_index=1, rect=RectangleObject([0, 0, 100, 100])), ) assert writer._get_page_layout() is None writer.page_layout = "broken" assert writer.page_layout == "broken" writer.page_layout = NameObject("/SinglePage") assert writer._get_page_layout() == "/SinglePage" assert writer._get_page_mode() is None writer.page_mode = "/UseNone" assert writer._get_page_mode() == "/UseNone" writer.page_mode = NameObject("/UseOC") assert writer._get_page_mode() == "/UseOC" writer.insert_blank_page(width=100, height=100) writer.insert_blank_page() # without parameters writer.remove_images() writer.add_metadata(reader.metadata) writer.add_metadata({"/Author": "Martin Thoma"}) writer.add_metadata({"/MyCustom": 1234}) writer.add_attachment("foobar.gif", b"foobarcontent") # Check that every key in _idnum_hash is correct objects_hash = [o.hash_value() for o in writer._objects] for k, v in writer._idnum_hash.items(): assert v.pdf == writer assert k in objects_hash, f"Missing {v}" @pytest.mark.parametrize( ("convert", "needs_cleanup"), [ (str, True), (Path, True), (BytesIO(), False), ], ) def test_writer_operations_by_traditional_usage(convert, needs_cleanup): write_data_here = _get_write_target(convert) writer = PdfWriter() writer_operate(writer) # finally, write "output" to pypdf-output.pdf if needs_cleanup: with open(write_data_here, "wb") as output_stream: writer.write(output_stream) else: output_stream = write_data_here writer.write(output_stream) if needs_cleanup: Path(write_data_here).unlink() @pytest.mark.parametrize( ("convert", "needs_cleanup"), [ (str, True), (Path, True), (BytesIO(), False), ], ) def test_writer_operations_by_semi_traditional_usage(convert, needs_cleanup): write_data_here = _get_write_target(convert) with PdfWriter() as writer: writer_operate(writer) # finally, write "output" to pypdf-output.pdf if needs_cleanup: with open(write_data_here, "wb") as output_stream: writer.write(output_stream) else: output_stream = write_data_here writer.write(output_stream) if needs_cleanup: Path(write_data_here).unlink() @pytest.mark.parametrize( ("convert", "needs_cleanup"), [ (str, True), (Path, True), (BytesIO(), False), ], ) def test_writer_operations_by_semi_new_traditional_usage(convert, needs_cleanup): write_data_here = _get_write_target(convert) with PdfWriter() as writer: writer_operate(writer) # finally, write "output" to pypdf-output.pdf writer.write(write_data_here) if needs_cleanup: Path(write_data_here).unlink() @pytest.mark.parametrize( ("convert", "needs_cleanup"), [ (str, True), (Path, True), (BytesIO(), False), ], ) def test_writer_operation_by_new_usage(convert, needs_cleanup): write_data_here = _get_write_target(convert) # This includes write "output" to pypdf-output.pdf with PdfWriter(write_data_here) as writer: writer_operate(writer) if needs_cleanup: Path(write_data_here).unlink() @pytest.mark.parametrize( "input_path", [ "side-by-side-subfig.pdf", "reportlab-inline-image.pdf", ], ) def test_remove_images(pdf_file_path, input_path): pdf_path = RESOURCE_ROOT / input_path reader = PdfReader(pdf_path) writer = PdfWriter() page = reader.pages[0] writer.insert_page(page, 0) writer.remove_images() page_contents_stream = writer.pages[0]["/Contents"]._data assert len(page_contents_stream.strip()) # finally, write "output" to pypdf-output.pdf with open(pdf_file_path, "wb") as output_stream: writer.write(output_stream) with open(pdf_file_path, "rb") as input_stream: reader = PdfReader(input_stream) if input_path == "side-by-side-subfig.pdf": extracted_text = reader.pages[0].extract_text() assert extracted_text assert "Lorem ipsum dolor sit amet" in extracted_text @pytest.mark.enable_socket def test_remove_images_sub_level(): """Cf #2035""" url = "https://github.com/py-pdf/pypdf/files/12394781/2210.03142-1.pdf" name = "iss2103.pdf" writer = PdfWriter(clone_from=BytesIO(get_data_from_url(url, name=name))) writer.remove_images() assert ( len( [ o.get_object() for o in writer.pages[0]["/Resources"]["/XObject"]["/Fm1"][ "/Resources" ]["/XObject"]["/Im1"]["/Resources"]["/XObject"].values() if not isinstance(o.get_object(), NullObject) ] ) == 0 ) @pytest.mark.parametrize( "input_path", [ "side-by-side-subfig.pdf", "reportlab-inline-image.pdf", ], ) def test_remove_text(input_path, pdf_file_path): pdf_path = RESOURCE_ROOT / input_path reader = PdfReader(pdf_path) writer = PdfWriter() page = reader.pages[0] writer.insert_page(page, 0) writer.remove_text() # finally, write "output" to pypdf-output.pdf with open(pdf_file_path, "wb") as output_stream: writer.write(output_stream) def test_remove_text_all_operators(pdf_file_path): stream = ( b"BT " b"/F0 36 Tf " b"50 706 Td " b"36 TL " b"(The Tj operator) Tj " b'1 2 (The double quote operator) " ' b"(The single quote operator) ' " b"ET" ) pdf_data = ( b"%%PDF-1.7\n" b"1 0 obj << /Count 1 /Kids [5 0 R] /Type /Pages >> endobj\n" b"2 0 obj << >> endobj\n" b"3 0 obj << >> endobj\n" b"4 0 obj << /Length %d >>\n" b"stream\n" + (b"%s\n" % stream) + b"endstream\n" b"endobj\n" b"5 0 obj << /Contents 4 0 R /CropBox [0.0 0.0 2550.0 3508.0]\n" b" /MediaBox [0.0 0.0 2550.0 3508.0] /Parent 1 0 R" b" /Resources << /Font << >> >>" b" /Rotate 0 /Type /Page >> endobj\n" b"6 0 obj << /Pages 1 0 R /Type /Catalog >> endobj\n" b"xref 1 6\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"%010d 00000 n\n" b"trailer << /Root 6 0 R /Size 6 >>\n" b"startxref\n%d\n" b"%%%%EOF" ) startx_correction = -1 pdf_data = pdf_data % ( len(stream), pdf_data.find(b"1 0 obj") + startx_correction, pdf_data.find(b"2 0 obj") + startx_correction, pdf_data.find(b"3 0 obj") + startx_correction, pdf_data.find(b"4 0 obj") + startx_correction, pdf_data.find(b"5 0 obj") + startx_correction, pdf_data.find(b"6 0 obj") + startx_correction, # startx_correction should be -1 due to double % at the beginning # inducing an error on startxref computation pdf_data.find(b"xref"), ) pdf_stream = BytesIO(pdf_data) reader = PdfReader(pdf_stream, strict=False) writer = PdfWriter() page = reader.pages[0] writer.insert_page(page, 0) writer.remove_text() # finally, write "output" to pypdf-output.pdf with open(pdf_file_path, "wb") as output_stream: writer.write(output_stream) def test_write_metadata(pdf_file_path): pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) writer = PdfWriter() writer.add_page(reader.pages[0]) for page in reader.pages: writer.add_page(page) metadata = reader.metadata writer.add_metadata(metadata) writer.add_metadata({"/Title": "The Crazy Ones"}) # finally, write data to pypdf-output.pdf with open(pdf_file_path, "wb") as output_stream: writer.write(output_stream) # Check if the title was set reader = PdfReader(pdf_file_path) metadata = reader.metadata assert metadata.get("/Title") == "The Crazy Ones" def test_fill_form(pdf_file_path): reader = PdfReader(RESOURCE_ROOT / "form.pdf") writer = PdfWriter() writer.append(reader, [0]) writer.append(RESOURCE_ROOT / "crazyones.pdf", [0]) writer.update_page_form_field_values( writer.pages[0], {"foo": "some filled in text"}, flags=1, flatten=True ) # check if no fields to fill in the page writer.update_page_form_field_values( writer.pages[1], {"foo": "some filled in text"}, flags=1, flatten=True ) writer.update_page_form_field_values( writer.pages[0], {"foo": "some filled in text"} ) # write "output" to pypdf-output.pdf with open(pdf_file_path, "wb") as output_stream: writer.write(output_stream) def test_fill_form_with_qualified(): reader = PdfReader(RESOURCE_ROOT / "form.pdf") reader.add_form_topname("top") writer = PdfWriter() writer.clone_document_from_reader(reader) writer.add_page(reader.pages[0]) writer.update_page_form_field_values( writer.pages[0], {"top.foo": "filling"}, flags=1 ) b = BytesIO() writer.write(b) reader2 = PdfReader(b) fields = reader2.get_fields() assert fields["top.foo"]["/V"] == "filling" @pytest.mark.parametrize( ("use_128bit", "user_password", "owner_password"), [(True, "userpwd", "ownerpwd"), (False, "userpwd", "ownerpwd")], ) def test_encrypt(use_128bit, user_password, owner_password, pdf_file_path): reader = PdfReader(RESOURCE_ROOT / "form.pdf") writer = PdfWriter() page = reader.pages[0] orig_text = page.extract_text() writer.add_page(page) writer.encrypt( owner_password=owner_password, user_password=user_password, use_128bit=use_128bit, ) writer.encrypt( user_password=user_password, owner_password=owner_password, use_128bit=use_128bit, ) # write "output" to pypdf-output.pdf with open(pdf_file_path, "wb") as output_stream: writer.write(output_stream) # Test that the data is not there in clear text with open(pdf_file_path, "rb") as input_stream: data = input_stream.read() assert b"foo" not in data # Test the user password (str): reader = PdfReader(pdf_file_path, password="userpwd") new_text = reader.pages[0].extract_text() assert reader.metadata.get("/Producer") == "pypdf" assert new_text == orig_text # Test the owner password (str): reader = PdfReader(pdf_file_path, password="ownerpwd") new_text = reader.pages[0].extract_text() assert reader.metadata.get("/Producer") == "pypdf" assert new_text == orig_text # Test the user password (bytes): reader = PdfReader(pdf_file_path, password=b"userpwd") new_text = reader.pages[0].extract_text() assert reader.metadata.get("/Producer") == "pypdf" assert new_text == orig_text # Test the owner password (bytes): reader = PdfReader(pdf_file_path, password=b"ownerpwd") new_text = reader.pages[0].extract_text() assert reader.metadata.get("/Producer") == "pypdf" assert new_text == orig_text def test_add_outline_item(pdf_file_path): reader = PdfReader(RESOURCE_ROOT / "pdflatex-outline.pdf") writer = PdfWriter() for page in reader.pages: writer.add_page(page) outline_item = writer.add_outline_item( "An outline item", 1, None, (255, 0, 15), True, True, Fit.fit(), is_open=False, ) _o2a = writer.add_outline_item( "Another", 2, outline_item, None, False, False, Fit.fit() ) _o2b = writer.add_outline_item( "Another bis", 2, outline_item, None, False, False, Fit.fit() ) outline_item2 = writer.add_outline_item( "An outline item 2", 1, None, (255, 0, 15), True, True, Fit.fit(), is_open=True, ) _o3a = writer.add_outline_item( "Another 2", 2, outline_item2, None, False, False, Fit.fit() ) _o3b = writer.add_outline_item( "Another 2bis", 2, outline_item2, None, False, False, Fit.fit() ) # write "output" to pypdf-output.pdf with open(pdf_file_path, "w+b") as output_stream: writer.write(output_stream) output_stream.seek(0) reader = PdfReader(output_stream) assert reader.trailer["/Root"]["/Outlines"]["/Count"] == 3 assert reader.outline[0]["/Count"] == -2 assert reader.outline[0]["/%is_open%"] == False # noqa: E712 assert reader.outline[2]["/Count"] == 2 assert reader.outline[2]["/%is_open%"] == True # noqa: E712 assert reader.outline[1][0]["/Count"] == 0 def test_add_named_destination(pdf_file_path): reader = PdfReader(RESOURCE_ROOT / "pdflatex-outline.pdf") writer = PdfWriter() assert writer.get_named_dest_root() == [] for page in reader.pages: writer.add_page(page) assert writer.get_named_dest_root() == [] writer.add_named_destination(TextStringObject("A named dest"), 2) writer.add_named_destination(TextStringObject("A named dest2"), 2) writer.add_named_destination(TextStringObject("A named dest3"), page_number=2) writer.add_named_destination(TextStringObject("A named dest3"), page_number=2) root = writer.get_named_dest_root() assert root[0] == "A named dest" assert root[1].pdf == writer assert root[1].get_object()["/S"] == NameObject("/GoTo") assert root[1].get_object()["/D"][0] == writer.pages[2].indirect_reference assert root[2] == "A named dest2" assert root[3].pdf == writer assert root[3].get_object()["/S"] == NameObject("/GoTo") assert root[3].get_object()["/D"][0] == writer.pages[2].indirect_reference assert root[4] == "A named dest3" # test get_object assert writer.get_object(root[1].idnum) == writer.get_object(root[1]) with pytest.raises(ValueError) as exc: writer.get_object(reader.pages[0].indirect_reference) assert exc.value.args[0] == "PDF must be self" # write "output" to pypdf-output.pdf with open(pdf_file_path, "wb") as output_stream: writer.write(output_stream) def test_add_named_destination_sort_order(pdf_file_path): """ Issue #1927 does not appear. add_named_destination() maintains the named destination list sort order """ writer = PdfWriter() assert writer.get_named_dest_root() == [] writer.add_blank_page(200, 200) writer.add_named_destination("b", 0) # "a" should be moved before "b" on insert writer.add_named_destination("a", 0) root = writer.get_named_dest_root() assert len(root) == 4 assert ( root[0] == "a" ), '"a" was not inserted before "b" in the named destination root' assert root[2] == "b" # write "output" to pypdf-output.pdf with open(pdf_file_path, "wb") as output_stream: writer.write(output_stream) def test_add_uri(pdf_file_path): reader = PdfReader(RESOURCE_ROOT / "pdflatex-outline.pdf") writer = PdfWriter() for page in reader.pages: writer.add_page(page) writer.add_uri( 1, "http://www.example.com", RectangleObject([0, 0, 100, 100]), border=[1, 2, 3, [4]], ) writer.add_uri( 2, "https://pypdf.readthedocs.io/en/latest/", RectangleObject([20, 30, 50, 80]), border=[1, 2, 3], ) writer.add_uri( 3, "https://pypdf.readthedocs.io/en/latest/user/adding-pdf-annotations.html", "[ 200 300 250 350 ]", border=[0, 0, 0], ) writer.add_uri( 3, "https://pypdf.readthedocs.io/en/latest/user/adding-pdf-annotations.html", [100, 200, 150, 250], border=[0, 0, 0], ) # write "output" to pypdf-output.pdf with open(pdf_file_path, "wb") as output_stream: writer.write(output_stream) def test_link_annotation(pdf_file_path): reader = PdfReader(RESOURCE_ROOT / "pdflatex-outline.pdf") writer = PdfWriter() for page in reader.pages: writer.add_page(page) writer.add_annotation( page_number=1, annotation=Link( target_page_index=2, rect=RectangleObject( [0, 0, 100, 100], ), border=[1, 2, 3, [4]], fit=Fit.fit(), ), ) writer.add_annotation( page_number=2, annotation=Link( target_page_index=3, rect=RectangleObject( [0, 0, 100, 100], ), border=[1, 2, 3], fit=Fit.fit_horizontally(), ), ) writer.add_annotation( page_number=3, annotation=Link( target_page_index=0, rect=RectangleObject( [200, 300, 250, 350], ), border=[0, 0, 0], fit=Fit.xyz(left=0, top=0, zoom=2), ), ) writer.add_annotation( page_number=3, annotation=Link( target_page_index=0, rect=RectangleObject([100, 200, 150, 250]), border=[0, 0, 0], ), ) # write "output" to pypdf-output.pdf with open(pdf_file_path, "wb") as output_stream: writer.write(output_stream) def test_io_streams(): """This is the example from the docs ("Streaming data").""" filepath = RESOURCE_ROOT / "pdflatex-outline.pdf" with open(filepath, "rb") as fh: bytes_stream = BytesIO(fh.read()) # Read from bytes stream reader = PdfReader(bytes_stream) assert len(reader.pages) == 4 # Write to bytes stream writer = PdfWriter() with BytesIO() as output_stream: writer.write(output_stream) def test_regression_issue670(pdf_file_path): filepath = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(filepath, strict=False) for _ in range(2): writer = PdfWriter() writer.add_page(reader.pages[0]) with open(pdf_file_path, "wb") as f_pdf: writer.write(f_pdf) def test_issue301(): """Test with invalid stream length object.""" with open(RESOURCE_ROOT / "issue-301.pdf", "rb") as f: reader = PdfReader(f) writer = PdfWriter() writer.append_pages_from_reader(reader) b = BytesIO() writer.write(b) def test_append_pages_from_reader_append(): """Use append_pages_from_reader with a callable.""" with open(RESOURCE_ROOT / "issue-301.pdf", "rb") as f: reader = PdfReader(f) writer = PdfWriter() writer.append_pages_from_reader(reader, callable) b = BytesIO() writer.write(b) @pytest.mark.enable_socket @pytest.mark.slow @pytest.mark.filterwarnings("ignore::DeprecationWarning") def test_sweep_indirect_references_nullobject_exception(pdf_file_path): # TODO: Check this more closely... this looks weird url = "https://github.com/user-attachments/files/18381699/tika-924666.pdf" name = "tika-924666.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) merger = PdfWriter() merger.append(reader) merger.write(pdf_file_path) @pytest.mark.enable_socket @pytest.mark.slow @pytest.mark.parametrize( ("url", "name"), [ ( "https://github.com/user-attachments/files/18381699/tika-924666.pdf", "test_sweep_indirect_references_nullobject_exception.pdf", ), ( "https://github.com/user-attachments/files/18381694/tika-922840.pdf", "test_write_outline_item_on_page_fitv.pdf", ), ("https://github.com/py-pdf/pypdf/files/10715624/test.pdf", "iss1627.pdf"), ], ) @pytest.mark.filterwarnings("ignore::DeprecationWarning") def test_some_appends(pdf_file_path, url, name): reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) merger = PdfWriter() merger.append(reader) merger.write(pdf_file_path) def test_pdf_header(): writer = PdfWriter() assert writer.pdf_header == "%PDF-1.3" reader = PdfReader(RESOURCE_ROOT / "crazyones.pdf") writer.add_page(reader.pages[0]) assert writer.pdf_header == "%PDF-1.5" writer.pdf_header = b"%PDF-1.6" assert writer.pdf_header == "%PDF-1.6" def test_write_dict_stream_object(pdf_file_path): stream = ( b"BT " b"/F0 36 Tf " b"50 706 Td " b"36 TL " b"(The Tj operator) Tj " b'1 2 (The double quote operator) " ' b"(The single quote operator) ' " b"ET" ) stream_object = StreamObject() stream_object[NameObject("/Type")] = NameObject("/Text") stream_object._data = stream writer = PdfWriter() page_object = PageObject.create_blank_page(writer, 1000, 1000) # Construct dictionary object (PageObject) with stream object # Writer will replace this stream object with indirect object page_object[NameObject("/Test")] = stream_object page_object = writer.add_page(page_object) with open(pdf_file_path, "wb") as fp: writer.write(fp) for k, v in page_object.items(): if k == "/Test": assert repr(v) != repr(stream_object) assert isinstance(v, IndirectObject) assert str(v) == str(stream_object) # expansion of IndirectObjects assert str(v.get_object()) == str(stream_object) break else: pytest.fail("/Test not found") # Check that every key in _idnum_hash is correct objects_hash = [o.hash_value() for o in writer._objects] for k, v in writer._idnum_hash.items(): assert v.pdf == writer assert k in objects_hash, f"Missing {v}" def test_add_single_annotation(pdf_file_path): pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) page = reader.pages[0] writer = PdfWriter() writer.add_page(page) annot_dict = { "/Type": "/Annot", "/Subtype": "/Text", "/Rect": [270.75, 596.25, 294.75, 620.25], "/Contents": "Note in second paragraph", "/C": [1, 1, 0], "/M": "D:20220406191858+02'00", "/Popup": { "/Type": "/Annot", "/Subtype": "/Popup", "/Rect": [294.75, 446.25, 494.75, 596.25], "/M": "D:20220406191847+02'00", }, "/T": "moose", } writer.add_annotation(0, annot_dict) # Inspect manually by adding 'assert False' and viewing the PDF with open(pdf_file_path, "wb") as fp: writer.write(fp) @pytest.mark.samples def test_colors_in_outline_item(pdf_file_path): reader = PdfReader(SAMPLE_ROOT / "004-pdflatex-4-pages/pdflatex-4-pages.pdf") writer = PdfWriter() writer.clone_document_from_reader(reader) purple_rgb = (0.5019607843137255, 0.0, 0.5019607843137255) writer.add_outline_item("First Outline Item", page_number=2, color="800080") writer.add_outline_item("Second Outline Item", page_number=3, color="#800080") writer.add_outline_item("Third Outline Item", page_number=4, color=purple_rgb) with open(pdf_file_path, "wb") as f: writer.write(f) reader2 = PdfReader(pdf_file_path) for outline_item in reader2.outline: # convert float to string because of mutability assert [f"{c:.5f}" for c in outline_item.color] == [ f"{p:.5f}" for p in purple_rgb ] @pytest.mark.samples def test_write_empty_stream(): reader = PdfReader(SAMPLE_ROOT / "004-pdflatex-4-pages/pdflatex-4-pages.pdf") writer = PdfWriter() writer.clone_document_from_reader(reader) with pytest.raises(ValueError) as exc: writer.write("") assert exc.value.args[0] == "Output(stream='') is empty." def test_startup_dest(): pdf_file_writer = PdfWriter() pdf_file_writer.append_pages_from_reader(PdfReader(RESOURCE_ROOT / "issue-604.pdf")) assert pdf_file_writer.open_destination is None pdf_file_writer.open_destination = pdf_file_writer.pages[9] # checked also using Acrobrat to verify the good page is opened op = pdf_file_writer.root_object["/OpenAction"] assert op[0] == pdf_file_writer.pages[9].indirect_reference assert op[1] == "/Fit" op = pdf_file_writer.open_destination assert op.raw_get("/Page") == pdf_file_writer.pages[9].indirect_reference assert op["/Type"] == "/Fit" pdf_file_writer.open_destination = op assert pdf_file_writer.open_destination == op # irrelevant, just for coverage pdf_file_writer.root_object[NameObject("/OpenAction")][0] = NumberObject(0) pdf_file_writer.open_destination with pytest.raises(Exception) as exc: del pdf_file_writer.root_object[NameObject("/OpenAction")][0] pdf_file_writer.open_destination assert "Invalid Destination" in str(exc.value) pdf_file_writer.open_destination = "Test" # checked also using Acrobrat to verify open_destination op = pdf_file_writer.root_object["/OpenAction"] assert isinstance(op, TextStringObject) assert op == "Test" op = pdf_file_writer.open_destination assert isinstance(op, TextStringObject) assert op == "Test" # irrelevant, this is just for coverage pdf_file_writer.root_object[NameObject("/OpenAction")] = NumberObject(0) assert pdf_file_writer.open_destination is None pdf_file_writer.open_destination = None assert "/OpenAction" not in pdf_file_writer.root_object pdf_file_writer.open_destination = None @pytest.mark.enable_socket def test_iss471(): url = "https://github.com/py-pdf/pypdf/files/9139245/book.pdf" name = "book_471.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() writer.append(reader, excluded_fields=[]) assert isinstance( writer.pages[0]["/Annots"][0].get_object()["/Dest"], TextStringObject ) @pytest.mark.enable_socket def test_reset_translation(): url = "https://github.com/user-attachments/files/18381699/tika-924666.pdf" name = "tika-924666.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() writer.append(reader, (0, 10)) nb = len(writer._objects) writer.append(reader, (0, 10)) assert ( len(writer._objects) == nb + 11 ) # +10 (pages) +1 because of the added outline nb += 1 writer.reset_translation(reader) writer.append(reader, (0, 10)) assert len(writer._objects) >= nb + 200 nb = len(writer._objects) writer.reset_translation(reader.pages[0].indirect_reference) writer.append(reader, (0, 10)) assert len(writer._objects) >= nb + 200 nb = len(writer._objects) writer.reset_translation() writer.append(reader, (0, 10)) assert len(writer._objects) >= nb + 200 nb = len(writer.pages) writer.append(reader, [reader.pages[0], reader.pages[0]]) assert len(writer.pages) == nb + 2 def test_threads_empty(): writer = PdfWriter() thr = writer.threads assert isinstance(thr, ArrayObject) assert len(thr) == 0 thr2 = writer.threads assert thr == thr2 @pytest.mark.enable_socket def test_append_without_annots_and_articles(): url = "https://github.com/user-attachments/files/18381699/tika-924666.pdf" name = "tika-924666.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() writer.append(reader, None, (0, 10), True, ["/B"]) writer.reset_translation() writer.append(reader, (0, 10), True, ["/B"]) assert writer.threads == [] writer = PdfWriter() writer.append(reader, None, (0, 10), True, ["/Annots"]) assert "/Annots" not in writer.pages[5] writer = PdfWriter() writer.append(reader, None, (0, 10), True, []) assert "/Annots" in writer.pages[5] assert len(writer.threads) >= 1 @pytest.mark.enable_socket def test_append_multiple(): url = "https://github.com/user-attachments/files/18381699/tika-924666.pdf" name = "tika-924666.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() writer.append( reader, [0, 0, 0] ) # to demonstre multiple insertion of same page at once writer.append(reader, [0, 0, 0]) # second pack pages = writer.root_object["/Pages"]["/Kids"] assert pages[0] not in pages[1:] # page not repeated assert pages[-1] not in pages[0:-1] # page not repeated @pytest.mark.samples def test_set_page_label(pdf_file_path): src = RESOURCE_ROOT / "GeoBase_NHNC1_Data_Model_UML_EN.pdf" # File without labels reader = PdfReader(src) expected = [ "i", "ii", "1", "2", "A", "B", "1", "2", "3", "4", "A", "i", "I", "II", "1", "2", "3", "I", "II", ] # Tests full length with labels assigned at first and last elements # Tests different labels assigned to consecutive ranges writer = PdfWriter(reader, full=True) writer.set_page_label(0, 1, "/r") writer.set_page_label(4, 5, "/A") writer.set_page_label(10, 10, "/A") writer.set_page_label(11, 11, "/r") writer.set_page_label(12, 13, "/R") writer.set_page_label(17, 18, "/R") writer.write(pdf_file_path) assert PdfReader(pdf_file_path).page_labels == expected writer = PdfWriter() # Same labels, different set order writer.clone_document_from_reader(reader) writer.set_page_label(17, 18, "/R") writer.set_page_label(4, 5, "/A") writer.set_page_label(10, 10, "/A") writer.set_page_label(0, 1, "/r") writer.set_page_label(12, 13, "/R") writer.set_page_label(11, 11, "/r") writer.write(pdf_file_path) assert PdfReader(pdf_file_path).page_labels == expected # Tests labels assigned only in the middle # Tests label assigned to a range already containing labelled ranges expected = ["1", "2", "i", "ii", "iii", "iv", "v", "1"] writer = PdfWriter() writer.clone_document_from_reader(reader) writer.set_page_label(3, 4, "/a") writer.set_page_label(5, 5, "/A") writer.set_page_label(2, 6, "/r") writer.write(pdf_file_path) assert PdfReader(pdf_file_path).page_labels[: len(expected)] == expected # Tests labels assigned inside a previously existing range expected = ["1", "2", "i", "a", "b", "A", "1", "1", "2"] # Ones repeat because user did not cover the entire original range writer = PdfWriter() writer.clone_document_from_reader(reader) writer.set_page_label(2, 6, "/r") writer.set_page_label(3, 4, "/a") writer.set_page_label(5, 5, "/A") writer.write(pdf_file_path) assert PdfReader(pdf_file_path).page_labels[: len(expected)] == expected # Tests invalid user input writer = PdfWriter() writer.clone_document_from_reader(reader) with pytest.raises( ValueError, match="At least one of style and prefix must be given" ): writer.set_page_label(0, 5, start=2) with pytest.raises( ValueError, match="page_index_from must be greater or equal than 0" ): writer.set_page_label(-1, 5, "/r") with pytest.raises( ValueError, match="page_index_to must be greater or equal than page_index_from" ): writer.set_page_label(5, 0, "/r") with pytest.raises(ValueError, match="page_index_to exceeds number of pages"): writer.set_page_label(0, 19, "/r") with pytest.raises( ValueError, match="If given, start must be greater or equal than one" ): writer.set_page_label(0, 5, "/r", start=-1) pdf_file_path.unlink() src = ( SAMPLE_ROOT / "009-pdflatex-geotopo/GeoTopo.pdf" ) # File with pre existing labels reader = PdfReader(src) # Tests adding labels to existing ones expected = ["i", "ii", "A", "B", "1"] writer = PdfWriter() writer.clone_document_from_reader(reader) writer.set_page_label(2, 3, "/A") writer.write(pdf_file_path) assert PdfReader(pdf_file_path).page_labels[: len(expected)] == expected # Tests replacing existing labels expected = ["A", "B", "1", "1", "2"] writer = PdfWriter() writer.clone_document_from_reader(reader) writer.set_page_label(0, 1, "/A") writer.write(pdf_file_path) assert PdfReader(pdf_file_path).page_labels[: len(expected)] == expected pdf_file_path.unlink() # Tests prefix and start. src = RESOURCE_ROOT / "issue-604.pdf" # File without page labels reader = PdfReader(src) writer = PdfWriter() writer.clone_document_from_reader(reader) writer.set_page_label(0, 0, prefix="FRONT") writer.set_page_label(1, 2, "/D", start=2) writer.set_page_label(3, 6, prefix="UPDATES") writer.set_page_label(7, 10, "/D", prefix="THYR-") writer.set_page_label(11, 21, "/D", prefix="PAP-") writer.set_page_label(22, 30, "/D", prefix="FOLL-") writer.set_page_label(31, 39, "/D", prefix="HURT-") writer.write(pdf_file_path) @pytest.mark.enable_socket def test_iss1601(): url = "https://github.com/py-pdf/pypdf/files/10579503/badges-38.pdf" name = "badge-38.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) original_cs_operations = ContentStream( reader.pages[0].get_contents(), reader ).operations writer = PdfWriter() page_1 = writer.add_blank_page( reader.pages[0].mediabox[2], reader.pages[0].mediabox[3] ) page_1.merge_transformed_page(reader.pages[0], Transformation()) page_1_cs_operations = page_1.get_contents().operations assert is_sublist(original_cs_operations, page_1_cs_operations) page_1 = writer.add_blank_page( reader.pages[0].mediabox[2], reader.pages[0].mediabox[3] ) page_1.merge_page(reader.pages[0]) page_1_cs_operations = page_1.get_contents().operations assert is_sublist(original_cs_operations, page_1_cs_operations) def test_attachments(): writer = PdfWriter() writer.add_blank_page(100, 100) b = BytesIO() writer.write(b) b.seek(0) reader = PdfReader(b) b = None assert reader.attachments == {} assert reader._list_attachments() == [] assert reader._get_attachments() == {} to_add = [ ("foobar.txt", b"foobarcontent"), ("foobar2.txt", b"foobarcontent2"), ("foobar2.txt", "2nd_foobarcontent"), ] for name, content in to_add: writer.add_attachment(name, content) b = BytesIO() writer.write(b) b.seek(0) reader = PdfReader(b) b = None assert sorted(reader.attachments.keys()) == sorted({name for name, _ in to_add}) assert str(reader.attachments) == "LazyDict(keys=['foobar.txt', 'foobar2.txt'])" assert reader._list_attachments() == [name for name, _ in to_add] # We've added the same key twice - hence only 2 and not 3: att = reader._get_attachments() assert len(att) == 2 # we have 2 keys, but 3 attachments! # The content for foobar.txt is clear and just a single value: assert att["foobar.txt"] == b"foobarcontent" # The content for foobar2.txt is a list! att = reader._get_attachments("foobar2.txt") assert len(att) == 1 assert att["foobar2.txt"] == [b"foobarcontent2", b"2nd_foobarcontent"] # Let's do both cases with the public interface: assert reader.attachments["foobar.txt"][0] == b"foobarcontent" assert reader.attachments["foobar2.txt"][0] == b"foobarcontent2" assert reader.attachments["foobar2.txt"][1] == b"2nd_foobarcontent" @pytest.mark.enable_socket def test_iss1614(): # test of an annotation(link) directly stored in the /Annots in the page url = "https://github.com/py-pdf/pypdf/files/10669995/broke.pdf" name = "iss1614.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() writer.append(reader) # test for 2nd error case reported in #1614 url = "https://github.com/py-pdf/pypdf/files/10696390/broken.pdf" name = "iss1614.2.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer.append(reader) @pytest.mark.enable_socket def test_new_removes(): # test of an annotation(link) directly stored in the /Annots in the page url = "https://github.com/py-pdf/pypdf/files/10807951/tt.pdf" name = "iss1650.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() writer.clone_document_from_reader(reader) writer.remove_images() b = BytesIO() writer.write(b) bb = bytes(b.getbuffer()) assert b"/Im0 Do" not in bb assert b"/Fm0 Do" in bb assert b" TJ" in bb writer = PdfWriter() writer.clone_document_from_reader(reader) writer.remove_text() b = BytesIO() writer.write(b) bb = bytes(b.getbuffer()) assert b"/Im0" in bb assert b"Chap" not in bb assert b" TJ" not in bb # Test removing text in a specified font writer = PdfWriter() writer.clone_document_from_reader(reader) b = BytesIO() writer.write(b) temp_reader = PdfReader(b) text = temp_reader.pages[0].extract_text() assert "Arbeitsschritt" in text assert "Modelltechnik" in text writer.remove_text(font_names=["LiberationSans-Bold"]) b = BytesIO() writer.write(b) temp_reader = PdfReader(b) text = temp_reader.pages[0].extract_text() assert "Arbeitsschritt" not in text assert "Modelltechnik" in text # Test removing text in a specified font that doesn't exist (nothing should happen) writer = PdfWriter() writer.clone_document_from_reader(reader) b = BytesIO() writer.write(b) temp_reader = PdfReader(b) text = temp_reader.pages[0].extract_text() assert "Arbeitsschritt" in text assert "Modelltechnik" in text writer.remove_text(font_names=["ComicSans-Oblique"]) b = BytesIO() writer.write(b) temp_reader = PdfReader(b) text = temp_reader.pages[0].extract_text() assert "Arbeitsschritt" in text assert "Modelltechnik" in text url = "https://github.com/py-pdf/pypdf/files/10832029/tt2.pdf" name = "GeoBaseWithComments.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer.append(reader) writer.remove_objects_from_page(writer.pages[0], [ObjectDeletionFlag.LINKS]) assert "/Links" not in [ a.get_object()["/Subtype"] for a in writer.pages[0]["/Annots"] ] writer.remove_objects_from_page(writer.pages[0], ObjectDeletionFlag.ATTACHMENTS) assert "/FileAttachment" not in [ a.get_object()["/Subtype"] for a in writer.pages[0]["/Annots"] ] writer.pages[0]["/Annots"].append( DictionaryObject({NameObject("/Subtype"): TextStringObject("/3D")}) ) assert "/3D" in [a.get_object()["/Subtype"] for a in writer.pages[0]["/Annots"]] writer.remove_objects_from_page(writer.pages[0], ObjectDeletionFlag.OBJECTS_3D) assert "/3D" not in [a.get_object()["/Subtype"] for a in writer.pages[0]["/Annots"]] writer.remove_links() assert len(writer.pages[0]["/Annots"]) == 0 assert len(writer.pages[3]["/Annots"]) == 0 writer.remove_annotations("/Text") @pytest.mark.enable_socket def test_late_iss1654(): url = "https://github.com/py-pdf/pypdf/files/10935632/bid1.pdf" name = "bid1.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() writer.clone_document_from_reader(reader) for p in writer.pages: p.compress_content_streams() b = BytesIO() writer.write(b) @pytest.mark.enable_socket def test_iss1723(): # test of an annotation(link) directly stored in the /Annots in the page url = "https://github.com/py-pdf/pypdf/files/11015242/inputFile.pdf" name = "iss1723.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() writer.append(reader, (3, 5)) @pytest.mark.enable_socket def test_iss1767(): # test with a pdf which is buggy because the object 389,0 exists 3 times: # twice to define catalog and one as an XObject inducing a loop when # cloning url = "https://github.com/py-pdf/pypdf/files/11138472/test.pdf" name = "iss1767.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) PdfWriter(clone_from=reader) @pytest.mark.enable_socket def test_named_dest_page_number(): """ Closes iss471 tests appending with named destinations as integers """ url = "https://github.com/py-pdf/pypdf/files/10704333/central.pdf" name = "central.pdf" writer = PdfWriter() writer.add_blank_page(100, 100) writer.append(BytesIO(get_data_from_url(url, name=name)), pages=[0, 1, 2]) assert len(writer.root_object["/Names"]["/Dests"]["/Names"]) == 2 assert writer.root_object["/Names"]["/Dests"]["/Names"][-1][0] == (1 + 1) writer.append(BytesIO(get_data_from_url(url, name=name))) assert len(writer.root_object["/Names"]["/Dests"]["/Names"]) == 6 writer2 = PdfWriter() writer2.add_blank_page(100, 100) dest = writer2.add_named_destination("toto", 0) dest.get_object()[NameObject("/D")][0] = NullObject() b = BytesIO() writer2.write(b) b.seek(0) writer.append(b) assert len(writer.root_object["/Names"]["/Dests"]["/Names"]) == 6 def test_update_form_fields(tmp_path): write_data_here = tmp_path / "out.pdf" writer = PdfWriter(clone_from=RESOURCE_ROOT / "FormTestFromOo.pdf") writer.update_page_form_field_values( writer.pages[0], { "CheckBox1": "/Yes", "Text1": "mon Text1", "Text2": "ligne1\nligne2", "RadioGroup1": "/2", "RdoS1": "/", "Combo1": "!!monCombo!!", "Liste1": "Liste2", "Liste2": ["Lst1", "Lst3"], "DropList1": "DropListe3", }, auto_regenerate=False, flatten=True, ) del writer.pages[0]["/Annots"][1].get_object()["/AP"]["/N"] del writer.pages[0]["/Resources"]["/Font"] writer.update_page_form_field_values( writer.pages[0], {"Text1": "my Text1", "Text2": "ligne1\nligne2\nligne3"}, auto_regenerate=False, ) writer.update_page_form_field_values( writer.pages[0], {"Text1": None, "Text2": None}, auto_regenerate=False, flatten=True, ) writer.write(write_data_here) reader = PdfReader(write_data_here) flds = reader.get_fields() assert flds["CheckBox1"]["/V"] == "/Yes" assert flds["CheckBox1"].indirect_reference.get_object()["/AS"] == "/Yes" assert ( b"(my Text1)" in flds["Text1"].indirect_reference.get_object()["/AP"]["/N"].get_data() ) assert flds["Text2"]["/V"] == "ligne1\nligne2\nligne3" assert ( b"(ligne3)" in flds["Text2"].indirect_reference.get_object()["/AP"]["/N"].get_data() ) assert flds["RadioGroup1"]["/V"] == "/2" assert flds["RadioGroup1"]["/Kids"][0].get_object()["/AS"] == "/Off" assert flds["RadioGroup1"]["/Kids"][1].get_object()["/AS"] == "/2" assert all(x in flds["Liste2"]["/V"] for x in ["Lst1", "Lst3"]) assert all(x in flds["CheckBox1"]["/_States_"] for x in ["/Off", "/Yes"]) assert all(x in flds["RadioGroup1"]["/_States_"] for x in ["/1", "/2", "/3"]) assert all(x in flds["Liste1"]["/_States_"] for x in ["Liste1", "Liste2", "Liste3"]) writer = PdfWriter(clone_from=RESOURCE_ROOT / "FormTestFromOo.pdf") writer.add_annotation( page_number=0, annotation=Link(target_page_index=1, rect=RectangleObject([0, 0, 100, 100])), ) writer.insert_blank_page(100, 100, 0) del writer.root_object["/AcroForm"]["/Fields"][1].get_object()["/DA"] del writer.root_object["/AcroForm"]["/Fields"][1].get_object()["/DR"]["/Font"] writer.update_page_form_field_values( [writer.pages[0], writer.pages[1]], {"Text1": "my Text1", "Text2": "ligne1\nligne2\nligne3"}, auto_regenerate=False, ) assert b"/Helv " in writer.pages[1]["/Annots"][1]["/AP"]["/N"].get_data() writer.update_page_form_field_values( None, {"Text1": "my Text1", "Text2": "ligne1\nligne2\nligne3"}, auto_regenerate=False, flatten=True ) Path(write_data_here).unlink() def test_add_apstream_object(): writer = PdfWriter() page = writer.add_blank_page(1000, 1000) assert NameObject("/Contents") not in page apstream_object = DecodedStreamObject.initialize_from_dictionary( { NameObject("/Type"): NameObject("/XObject"), NameObject("/Subtype"): NameObject("/Form"), NameObject("/BBox"): RectangleObject([0.0, 0.0, 10.5, 10.5]), "__streamdata__": ByteStringObject(b"BT /F1 12 Tf (Hello World) Tj ET") } ) writer._add_object(apstream_object) object_name = "AA2342!@#$% ^^##aa:-)" x_offset = 200 y_offset = 200 writer._add_apstream_object(page, apstream_object, object_name, x_offset, y_offset) assert NameObject("/XObject") in page[NameObject("/Resources")] assert "/Fm_AA2342__________aa_-_" in page[NameObject("/Resources")][NameObject("/XObject")] assert NameObject("/Contents") in page contents_obj = page[NameObject("/Contents")] stream = contents_obj.get_object() assert isinstance(stream, StreamObject) assert stream.get_data() == ( b"q\n1.0000 0.0000 0.0000 1.0000 200.0000 200.0000 cm\n/Fm_AA2342__________aa_-_ Do\nQ" ) def test_merge_content_stream_to_page(): """Test that new content data is correctly added to page contents in the form of an ArrayObject or StreamObject. The test_add_apstream_object code already correctly checks that _merge_content_stream_to_page works for an emtpy page. """ writer = PdfWriter() page = writer.add_blank_page(100, 100) new_content = b"BT /F1 12 Tf (Hello World) Tj ET" # Call the method under test writer._merge_content_stream_to_page(page, new_content) more_content = b"BT /F1 12 Tf (Hello Again, World) Tj ET" writer._merge_content_stream_to_page(page, more_content) contents_obj = page[NameObject("/Contents")] stream = contents_obj.get_object() assert isinstance(stream, StreamObject) assert stream.get_data() == b"BT /F1 12 Tf (Hello World) Tj ET\nBT /F1 12 Tf (Hello Again, World) Tj ET" new_stream_obj = StreamObject() new_stream_obj.set_data(new_content) content = ArrayObject() content.append(new_stream_obj) page[NameObject("/Contents")] = writer._add_object(content) writer._merge_content_stream_to_page(page, more_content) contents_obj = page[NameObject("/Contents")] array = contents_obj.get_object() assert isinstance(array, ArrayObject) contents = page[NameObject("/Contents")].get_object() assert contents[0].get_object().get_data() == new_content assert contents[1].get_object().get_data() == more_content @pytest.mark.enable_socket def test_update_form_fields2(): my_files = { "test1": { "name": "Test1 Form", "url": "https://github.com/py-pdf/pypdf/files/14817365/test1.pdf", "path": "iss2234a.pdf", "usage": { "fields": { "First Name": "Reed", "Middle Name": "R", "MM": "04", "DD": "21", "YY": "24", "Initial": "RRG", # "I DO NOT Agree": null, # "Last Name": null }, }, }, "test2": { "name": "Test2 Form", "url": "https://github.com/py-pdf/pypdf/files/14817366/test2.pdf", "path": "iss2234b.pdf", "usage": { "fields": { "p2 First Name": "Joe", "p2 Middle Name": "S", "p2 MM": "03", "p2 DD": "31", "p2 YY": "24", "Initial": "JSS", # "p2 I DO NOT Agree": "null", "p2 Last Name": "Smith", "p3 First Name": "John", "p3 Middle Name": "R", "p3 MM": "01", "p3 DD": "25", "p3 YY": "21", }, }, }, } merger = PdfWriter() for file in my_files: reader = PdfReader( BytesIO(get_data_from_url(my_files[file]["url"], name=my_files[file]["path"])) ) reader.add_form_topname(file) writer = PdfWriter(clone_from=reader) writer.update_page_form_field_values( None, my_files[file]["usage"]["fields"], auto_regenerate=True ) merger.append(writer) assert merger.get_form_text_fields(True) == { "test1.First Name": "Reed", "test1.Middle Name": "R", "test1.MM": "04", "test1.DD": "21", "test1.YY": "24", "test1.Initial": "RRG", "test1.I DO NOT Agree": None, "test1.Last Name": None, "test2.p2 First Name": "Joe", "test2.p2 Middle Name": "S", "test2.p2 MM": "03", "test2.p2 DD": "31", "test2.p2 YY": "24", "test2.Initial": "JSS", "test2.p2 I DO NOT Agree": None, "test2.p2 Last Name": "Smith", "test2.p3 First Name": "John", "test2.p3 Middle Name": "R", "test2.p3 MM": "01", "test2.p3 DD": "25", "test2.p3 YY": "21", } @pytest.mark.enable_socket def test_iss1862(): # The file here has "/B" entry to define the font in a object below the page # The excluded field shall be considered only at first level (page) and not # below url = "https://github.com/py-pdf/pypdf/files/11708801/intro.pdf" name = "iss1862.pdf" writer = PdfWriter() writer.append(BytesIO(get_data_from_url(url, name=name))) # check that "/B" is in the font writer.pages[0]["/Resources"]["/Font"]["/F1"]["/CharProcs"]["/B"].get_data() def test_empty_objects_before_cloning(): pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) writer = PdfWriter(clone_from=reader) nb_obj_reader = len(reader.xref_objStm) + sum( len(reader.xref[i]) for i in reader.xref ) nb_obj_reader -= 1 # for trailer nb_obj_reader -= len( {x: 1 for x, y in reader.xref_objStm.values()} ) # to remove object streams assert len(writer._objects) == nb_obj_reader @pytest.mark.enable_socket def test_watermark(): url = "https://github.com/py-pdf/pypdf/files/11985889/bg.pdf" name = "bgwatermark.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) url = "https://github.com/py-pdf/pypdf/files/11985888/source.pdf" name = "srcwatermark.pdf" writer = PdfWriter(clone_from=BytesIO(get_data_from_url(url, name=name))) for p in writer.pages: p.merge_page(reader.pages[0], over=False) assert isinstance(p["/Contents"], ArrayObject) assert isinstance(p["/Contents"][0], IndirectObject) b = BytesIO() writer.write(b) assert len(b.getvalue()) < 2.1 * 1024 * 1024 @pytest.mark.enable_socket @pytest.mark.timeout(4) def test_watermarking_speed(): url = "https://github.com/py-pdf/pypdf/files/11985889/bg.pdf" name = "bgwatermark.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) url = "https://arxiv.org/pdf/2201.00214.pdf" name = "2201.00214.pdf" writer = PdfWriter(clone_from=BytesIO(get_data_from_url(url, name=name))) for p in writer.pages: p.merge_page(reader.pages[0], over=False) out_pdf_bytesio = BytesIO() writer.write(out_pdf_bytesio) pdf_size_in_mib = len(out_pdf_bytesio.getvalue()) / 1024 / 1024 assert pdf_size_in_mib < 20 @pytest.mark.enable_socket @pytest.mark.skipif(GHOSTSCRIPT_BINARY is None, reason="Requires Ghostscript") def test_watermark_rendering(tmp_path): """Ensure the visual appearance of watermarking stays correct.""" url = "https://github.com/py-pdf/pypdf/files/11985889/bg.pdf" name = "bgwatermark.pdf" watermark = PdfReader(BytesIO(get_data_from_url(url, name=name))).pages[0] url = "https://github.com/py-pdf/pypdf/files/11985888/source.pdf" name = "srcwatermark.pdf" page = PdfReader(BytesIO(get_data_from_url(url, name=name))).pages[0] writer = PdfWriter() page.merge_page(watermark, over=False) writer.add_page(page) target_png_path = tmp_path / "target.png" url = "https://github.com/py-pdf/pypdf/assets/96178532/d5c72d0e-7047-4504-bbf6-bc591c80d7c0" name = "dstwatermark.png" target_png_path.write_bytes(get_data_from_url(url, name=name)) pdf_path = tmp_path / "out.pdf" png_path = tmp_path / "out.png" writer.write(pdf_path) # False positive: https://github.com/PyCQA/bandit/issues/333 subprocess.run( # noqa: S603 [ GHOSTSCRIPT_BINARY, "-sDEVICE=pngalpha", "-o", png_path, pdf_path, ] ) assert png_path.is_file() assert image_similarity(png_path, target_png_path) >= 0.95 @pytest.mark.samples @pytest.mark.skipif(GHOSTSCRIPT_BINARY is None, reason="Requires Ghostscript") def test_watermarking_reportlab_rendering(tmp_path): """ This test is showing a rotated+mirrored watermark in pypdf==3.15.4. Replacing the generate_base with e.g. the crazyones did not show the issue. """ base_path = SAMPLE_ROOT / "022-pdfkit/pdfkit.pdf" watermark_path = SAMPLE_ROOT / "013-reportlab-overlay/reportlab-overlay.pdf" reader = PdfReader(base_path) base_page = reader.pages[0] watermark = PdfReader(watermark_path).pages[0] writer = PdfWriter() base_page.merge_page(watermark) writer.add_page(base_page) target_png_path = RESOURCE_ROOT / "test_watermarking_reportlab_rendering.png" pdf_path = tmp_path / "out.pdf" png_path = tmp_path / "test_watermarking_reportlab_rendering.png" writer.write(pdf_path) # False positive: https://github.com/PyCQA/bandit/issues/333 subprocess.run( # noqa: S603 [ GHOSTSCRIPT_BINARY, "-r120", "-sDEVICE=pngalpha", "-o", png_path, pdf_path, ] ) assert png_path.is_file() assert image_similarity(png_path, target_png_path) >= 0.999 @pytest.mark.enable_socket def test_da_missing_in_annot(): url = "https://github.com/py-pdf/pypdf/files/12136285/Building.Division.Permit.Application.pdf" name = "BuildingDivisionPermitApplication.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter(clone_from=reader) writer.update_page_form_field_values( writer.pages[0], {"PCN-1": "0"}, auto_regenerate=False ) b = BytesIO() writer.write(b) reader = PdfReader(BytesIO(b.getvalue())) ff = reader.get_fields() # check for autosize processing assert ( b"0 Tf" not in ff["PCN-1"].indirect_reference.get_object()["/AP"]["/N"].get_data() ) f2 = writer.get_object(ff["PCN-2"].indirect_reference.idnum) f2[NameObject("/Parent")] = writer.get_object( ff["PCN-1"].indirect_reference.idnum ).indirect_reference writer.update_page_form_field_values( writer.pages[0], {"PCN-2": "1"}, auto_regenerate=False ) def test_missing_fields(pdf_file_path): reader = PdfReader(RESOURCE_ROOT / "form.pdf") writer = PdfWriter() writer.add_page(reader.pages[0]) with pytest.raises(PyPdfError) as exc: writer.update_page_form_field_values( writer.pages[0], {"foo": "some filled in text"}, flags=1 ) assert exc.value.args[0] == "No /AcroForm dictionary in PDF of PdfWriter Object" writer = PdfWriter() writer.append(reader, [0]) del writer.root_object["/AcroForm"]["/Fields"] with pytest.raises(PyPdfError) as exc: writer.update_page_form_field_values( writer.pages[0], {"foo": "some filled in text"}, flags=1 ) assert exc.value.args[0] == "No /Fields dictionary in PDF of PdfWriter Object" def test_missing_info(): reader = PdfReader(RESOURCE_ROOT / "missing_info.pdf") writer = PdfWriter(clone_from=reader) assert len(writer.pages) == len(reader.pages) assert writer.metadata is None b = BytesIO() writer.write(b) assert b"/Info" not in b.getvalue() reader = PdfReader(RESOURCE_ROOT / "crazyones.pdf") writer.metadata = reader.metadata assert dict(writer._info) == dict(reader._info) assert writer.metadata == reader.metadata b = BytesIO() writer.write(b) assert b"/Info" in b.getvalue() writer.metadata = {} writer._info = DictionaryObject() # for code coverage b = BytesIO() writer.write(b) assert b"/Info" in b.getvalue() assert writer.metadata == {} writer.metadata = None writer.metadata = None # for code coverage assert writer.metadata is None assert PdfWriter().metadata == {"/Producer": "pypdf"} b = BytesIO() writer.write(b) assert b"/Info" not in b.getvalue() @pytest.mark.enable_socket def test_germanfields(): """Cf #2035""" url = "https://github.com/py-pdf/pypdf/files/12194195/test.pdf" name = "germanfields.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter(clone_from=reader) form_fields = {"Text Box 1": "test æ ø ĂĄ"} writer.update_page_form_field_values( writer.pages[0], form_fields, auto_regenerate=False ) bytes_stream = BytesIO() writer.write(bytes_stream) bytes_stream.seek(0) reader2 = PdfReader(bytes_stream) assert ( b"test \xe6 \xf8 \xe5" in reader2.get_fields()["Text Box 1"] .indirect_reference.get_object()["/AP"]["/N"] .get_data() ) @pytest.mark.enable_socket def test_no_t_in_articles(): """Cf #2078""" url = "https://github.com/py-pdf/pypdf/files/12311735/bad.pdf" name = "iss2078.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() writer.append(reader) @pytest.mark.enable_socket def test_no_i_in_articles(): """Cf #2089""" url = "https://github.com/py-pdf/pypdf/files/12352793/kim2002.pdf" name = "iss2089.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() writer.append(reader) @pytest.mark.enable_socket def test_damaged_pdf_length_returning_none(): """ Cf #140 https://github.com/py-pdf/pypdf/issues/140#issuecomment-1685380549 """ url = "https://github.com/py-pdf/pypdf/files/12168578/bad_pdf_example.pdf" name = "iss140_bad_pdf.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() writer.append(reader) @pytest.mark.enable_socket def test_viewerpreferences(): """Add Tests for ViewerPreferences""" url = "https://github.com/py-pdf/pypdf/files/9175966/2015._pb_decode_pg0.pdf" name = "2015._pb_decode_pg0.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) v = reader.viewer_preferences assert v.center_window == True # noqa: E712 writer = PdfWriter(clone_from=reader) v = writer.viewer_preferences assert v.center_window == True # noqa: E712 v.center_window = False assert ( writer.root_object["/ViewerPreferences"]["/CenterWindow"] == False # noqa: E712 ) assert v.print_area == "/CropBox" with pytest.raises(ValueError): v.non_fullscreen_pagemode = "toto" with pytest.raises(ValueError): v.non_fullscreen_pagemode = "/toto" v.non_fullscreen_pagemode = "/UseOutlines" assert ( writer.root_object["/ViewerPreferences"]["/NonFullScreenPageMode"] == "/UseOutlines" ) writer = PdfWriter(clone_from=reader) v = writer.viewer_preferences assert v.center_window == True # noqa: E712 v.center_window = False assert ( writer.root_object["/ViewerPreferences"]["/CenterWindow"] == False # noqa: E712 ) writer = PdfWriter(clone_from=reader) writer.root_object[NameObject("/ViewerPreferences")] = writer._add_object( writer.root_object["/ViewerPreferences"] ) v = writer.viewer_preferences v.center_window = False assert ( writer.root_object["/ViewerPreferences"]["/CenterWindow"] == False # noqa: E712 ) v.num_copies = 1 assert v.num_copies == 1 assert v.print_pagerange is None with pytest.raises(ValueError): v.print_pagerange = "toto" v.print_pagerange = ArrayObject() assert len(v.print_pagerange) == 0 writer.create_viewer_preferences() assert len(writer.root_object["/ViewerPreferences"]) == 0 writer.viewer_preferences.direction = "/R2L" assert len(writer.root_object["/ViewerPreferences"]) == 1 assert writer.viewer_preferences.enforce == [] assert "/Enforce" not in writer.viewer_preferences writer.viewer_preferences.enforce += writer.viewer_preferences.PRINT_SCALING assert writer.viewer_preferences["/Enforce"] == ["/PrintScaling"] writer.viewer_preferences.enforce = None assert "/Enforce" not in writer.viewer_preferences writer.viewer_preferences.enforce = None del reader.trailer["/Root"]["/ViewerPreferences"] assert reader.viewer_preferences is None writer = PdfWriter(clone_from=reader) assert writer.viewer_preferences is None def test_extra_spaces_in_da_text(caplog): writer = PdfWriter(clone_from=RESOURCE_ROOT / "form.pdf") t = writer.pages[0]["/Annots"][0].get_object()["/DA"] t = t.replace("/Helv", "/Helv ") writer.pages[0]["/Annots"][0].get_object()[NameObject("/DA")] = TextStringObject(t) writer.update_page_form_field_values( writer.pages[0], {"foo": "abcd"}, auto_regenerate=False ) t = writer.pages[0]["/Annots"][0].get_object()["/AP"]["/N"].get_data() assert "Font dictionary for not found." not in caplog.text assert b"/Helv" in t assert b"(abcd)" in t @pytest.mark.enable_socket def test_object_contains_indirect_reference_to_self(): url = "https://github.com/py-pdf/pypdf/files/12389243/testbook.pdf" name = "iss2102.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() width, height = 595, 841 outpage = writer.add_blank_page(width, height) outpage.merge_page(reader.pages[6]) writer.append(reader) def test_remove_image_per_type(): writer = PdfWriter(clone_from=RESOURCE_ROOT / "reportlab-inline-image.pdf") writer.remove_images(ImageType.INLINE_IMAGES) assert all( x not in writer.pages[0].get_contents().get_data() for x in (b"BI", b"ID", b"EI") ) writer.remove_images() writer = PdfWriter(clone_from=RESOURCE_ROOT / "GeoBase_NHNC1_Data_Model_UML_EN.pdf") writer.remove_images(ImageType.DRAWING_IMAGES) assert all( x not in writer.pages[1].get_contents().get_data() for x in (b" re\n", b"W*", b"f*") ) assert all( x in writer.pages[1].get_contents().get_data() for x in (b" TJ\n", b"rg", b"Tm") ) assert all( x not in writer.pages[9]["/Resources"]["/XObject"]["/Meta84"].get_data() for x in (b" re\n", b"W*", b"f*") ) writer.remove_images(ImageType.XOBJECT_IMAGES) assert b"Do\n" not in writer.pages[0].get_contents().get_data() assert len(writer.pages[0]["/Resources"]["/XObject"]) == 0 @pytest.mark.enable_socket def test_add_outlines_on_empty_dict(): """Cf #2233""" def _get_parent_bookmark(current_indent, history_indent, bookmarks) -> Any: """The parent of A is the nearest bookmark whose indent is smaller than A's""" assert len(history_indent) == len(bookmarks) if current_indent == 0: return None for i in range(len(history_indent) - 1, -1, -1): # len(history_indent) - 1 ===> 0 if history_indent[i] < current_indent: return bookmarks[i] return None bookmark_lines = """1 FUNDAMENTALS OF RADIATIVE TRANSFER 1 1.1 The Electromagnetic Spectrum; Elementary Properties of Radiation 1 1.2 Radiative Flux 2 Macroscopic Description of the Propagation of Radiation 2 Flux from an Isotropic Source-The Inverse Square Law 2 1.3 The Specific Intensity and Its Moments 3 Definition of Specific Intensity or Brightness 3 Net Flux and Momentum Flux 4 Radiative Energy Density 5 Radiation Pressure in an Enclosure Containing an Isotropic Radiation Field 6 Constancy of Specific Zntensiw Along Rays in Free Space 7 Proof of the Inverse Square Law for a Uniformly Bright Sphere 7 1.4 Radiative Transfer 8 Emission 9 Absorption 9 The Radiative Transfer Equation 11 Optical Depth and Source Function 12 Mean Free Path 14 Radiation Force 15 1.5 Thermal Radiation 15 Blackbody Radiation 15 Kirchhof's Law for Thermal Emission 16 Thermodynamics of Blackbody Radiation 17 The Planck Spectrum 20 Properties of the Planck Law 23 Characteristic Temperatures Related to Planck Spectrum 25 1.6 The Einstein Coefficients 27 Definition of Coefficients 27 Relations between Einstein Coefficients 29 Absorption and Emission Coefficients in Terms of Einstein Coefficients 30 1.7 Scattering Effects; Random Walks 33 Pure Scattering 33 Combined Scattering and Absorption 36 1.8 Radiative Diffusion 39 The Rosseland Approximation 39 The Eddington Approximation; Two-Stream Approximation 42 PROBLEMS 45 REFERENCES 50 2 BASIC THEORY OF RADIATION FIELDS 51 2.1 Review of Maxwell’s Equations 51 2.2 Plane Electromagnetic Waves 55 2.3 The Radiation Spectrum 58 2.4 Polarization and Stokes Parameters 62 Monochromatic Waves 62 Quasi-monochromatic Waves 65 2.5 Electromagnetic Potentials 69 2.6 Applicability of Transfer Theory and the Geometrical Optics Limit 72 PROBLEMS 74 REFERENCES 76""" url = "https://github.com/py-pdf/pypdf/files/12797067/test-12.pdf" name = "iss2233.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter(clone_from=reader) bookmarks, history_indent = [], [] for line in bookmark_lines.split("\n"): line2 = re.split(r"\s+", line.strip()) indent_size = len(line) - len(line.lstrip()) parent = _get_parent_bookmark(indent_size, history_indent, bookmarks) history_indent.append(indent_size) title, page = " ".join(line2[:-1]), int(line2[-1]) - 1 new_bookmark = writer.add_outline_item(title, page, parent=parent) bookmarks.append(new_bookmark) def test_merging_many_temporary_files(caplog): def create_number_pdf(_n) -> BytesIO: pytest.importorskip("fpdf") from fpdf import FPDF # noqa: PLC0415 pdf = FPDF() pdf.add_page() pdf.set_font("helvetica", "B", 16) pdf.cell(40, 10, str(_n)) byte_string = pdf.output() return BytesIO(byte_string) writer = PdfWriter() for n in range(100): reader = PdfReader(create_number_pdf(n)) for page in reader.pages: # Should only be one page. writer.add_page(page) pg = PageObject.create_blank_page(writer, 1000, 1000) pg1 = writer.add_page(pg) assert len(writer.pages) == 101 caplog.clear() writer.remove_page(pg) assert "Cannot find page in pages" in caplog.text assert len(writer.pages) == 101 writer.remove_page(pg1) assert len(writer.pages) == 100 out = BytesIO() writer.write(out) out.seek(0) reader = PdfReader(out) for n, page in enumerate(reader.pages): text = page.extract_text() assert text == str(n) # test completed to validate remove_page writer.remove_page(writer.pages[-1], True) writer2 = PdfWriter() writer2.remove_page(0) writer2.flattened_pages = None writer2.remove_page(0) caplog.clear() writer.remove_page(writer.pages[-1]["/Contents"].indirect_reference) assert "IndirectObject is not referencing a page" in caplog.text caplog.clear() pg = PageObject.create_blank_page(writer, 1000, 1000) writer.remove_page(pg) assert "Cannot find page in pages" in caplog.text caplog.clear() writer.remove_page(999999) assert "Page number is out of range" in caplog.text pg = PageObject.create_blank_page(writer, 1000, 1000) pg = writer._add_object(pg) writer.flattened_pages.append(pg) caplog.clear() writer.remove_page(pg) assert "Cannot find page in pages" in caplog.text @pytest.mark.enable_socket def test_reattach_fields(): """ Test Reattach function addressed in #2453 """ url = "https://github.com/py-pdf/pypdf/files/14241368/ExampleForm.pdf" name = "iss2453.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() for p in reader.pages: writer.add_page(p) assert len(writer.reattach_fields()) == 15 assert len(writer.reattach_fields()) == 0 # nothing to append anymore assert len(writer.root_object["/AcroForm"]["/Fields"]) == 15 writer = PdfWriter(clone_from=reader) assert len(writer.reattach_fields()) == 7 writer.reattach_fields() assert len(writer.root_object["/AcroForm"]["/Fields"]) == 15 writer = PdfWriter() for p in reader.pages: writer.add_page(p) ano = writer.pages[0]["/Annots"][0].get_object() del ano.indirect_reference writer.pages[0]["/Annots"][0] = ano assert isinstance(writer.pages[0]["/Annots"][0], DictionaryObject) assert len(writer.reattach_fields(writer.pages[0])) == 6 assert isinstance(writer.pages[0]["/Annots"][0], IndirectObject) del writer.pages[1]["/Annots"] assert len(writer.reattach_fields(writer.pages[1])) == 0 def test_get_pagenumber_from_indirectobject(): """Test test_get_pagenumber_from_indirectobject""" pdf_path = RESOURCE_ROOT / "crazyones.pdf" writer = PdfWriter(clone_from=pdf_path) assert writer._get_page_number_by_indirect(None) is None assert writer._get_page_number_by_indirect(NullObject()) is None ind = writer.pages[0].indirect_reference assert writer._get_page_number_by_indirect(ind) == 0 assert writer._get_page_number_by_indirect(ind.idnum) == 0 assert writer._get_page_number_by_indirect(ind.idnum + 1) is None def test_replace_object(): pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) writer = PdfWriter(clone_from=reader) with pytest.raises(ValueError): writer._replace_object(reader.pages[0].indirect_reference, reader.pages[0]) writer._replace_object(writer.pages[0].indirect_reference, reader.pages[0]) pg = PageObject.create_blank_page(writer, 1000, 1000) writer._replace_object(writer.pages[0].indirect_reference, pg) # mainly for coverage reader = PdfReader(pdf_path) # reload a new instance with pytest.raises(ValueError): reader._replace_object(writer.pages[0].indirect_reference, reader.pages[0]) with pytest.raises(ValueError): reader._replace_object(IndirectObject(9999, 9999, reader), reader.pages[0]) reader._replace_object(reader.pages[0].indirect_reference, reader.pages[0]) pg = PageObject.create_blank_page(writer, 1000, 1000) reader._replace_object(reader.pages[0].indirect_reference, pg) pg = PageObject.create_blank_page(None, 1000, 1000) pg[NameObject("/Contents")] = writer.pages[0]["/Contents"] writer._add_object(pg) writer.add_page(pg) def test_mime_jupyter(): pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) writer = PdfWriter(clone_from=reader) assert reader._repr_mimebundle_(("include",), ("exclude",)) == {} assert writer._repr_mimebundle_(("include",), ("exclude",)) == {} def test_init_without_named_arg(): """Test to use file_obj argument and not clone_from""" pdf_path = RESOURCE_ROOT / "crazyones.pdf" reader = PdfReader(pdf_path) writer = PdfWriter(clone_from=reader) nb = len(writer._objects) writer = PdfWriter(reader) assert len(writer._objects) == nb with open(pdf_path, "rb") as f: writer = PdfWriter(f) f.seek(0, 0) by = BytesIO(f.read()) assert len(writer._objects) == nb writer = PdfWriter(pdf_path) assert len(writer._objects) == nb writer = PdfWriter(str(pdf_path)) assert len(writer._objects) == nb writer = PdfWriter(by) assert len(writer._objects) == nb @pytest.mark.enable_socket def test_i_in_choice_fields(): """Cf #2611""" url = "https://github.com/py-pdf/pypdf/files/15176321/FRA.F.6180.150.pdf" name = "iss2611.pdf" writer = PdfWriter(BytesIO(get_data_from_url(url, name=name))) assert "/I" in writer.get_fields()["State"].indirect_reference.get_object() writer.update_page_form_field_values( writer.pages[0], {"State": "NY"}, auto_regenerate=False ) assert "/I" not in writer.get_fields()["State"].indirect_reference.get_object() def test_selfont(): writer = PdfWriter(clone_from=RESOURCE_ROOT / "FormTestFromOo.pdf") writer.update_page_form_field_values( writer.pages[0], {"Text1": ("Text_1", "", 5), "Text2": ("Text_2", "/F3", 0)}, auto_regenerate=False, ) assert ( b"/F3 5 Tf" in writer.pages[0]["/Annots"][1].get_object()["/AP"]["/N"].get_data() ) assert ( b"Text_1" in writer.pages[0]["/Annots"][1].get_object()["/AP"]["/N"].get_data() ) assert ( b"/F3 12 Tf" in writer.pages[0]["/Annots"][2].get_object()["/AP"]["/N"].get_data() ) assert ( b"Text_2" in writer.pages[0]["/Annots"][2].get_object()["/AP"]["/N"].get_data() ) @pytest.mark.enable_socket def test_no_resource_for_14_std_fonts(caplog): """Cf #2670""" url = "https://github.com/py-pdf/pypdf/files/15405390/f1040.pdf" name = "iss2670.pdf" writer = PdfWriter(BytesIO(get_data_from_url(url, name=name))) p = writer.pages[0] for a in p["/Annots"]: a = a.get_object() if a["/FT"] == "/Tx": writer.update_page_form_field_values( p, {a["/T"]: "Brooks"}, auto_regenerate=False ) assert "Font dictionary for /Helvetica not found." in caplog.text @pytest.mark.enable_socket def test_field_box_upside_down(): """Cf #2724""" url = "https://github.com/user-attachments/files/15996356/FRA.F.6180.55.pdf" name = "iss2724.pdf" writer = PdfWriter(BytesIO(get_data_from_url(url, name=name))) writer.update_page_form_field_values(None, {"FreightTrainMiles": "0"}) assert writer.pages[0]["/Annots"][13].get_object()["/AP"]["/N"].get_data() == ( b"q\n/Tx BMC \nq\n1 1 105.29520000000001 10.835000000000036 re\n" b"W\nBT\n/Arial 8.0 Tf 0 g\n2 2.8350000000000364 Td\n(0) Tj\nET\n" b"Q\nEMC\nQ\n" ) box = writer.pages[0]["/Annots"][13].get_object()["/AP"]["/N"]["/BBox"] assert box[2] > 0 assert box[3] > 0 @pytest.mark.enable_socket def test_matrix_entry_in_field_annots(): """Cf #2731""" url = "https://github.com/user-attachments/files/16036514/template.pdf" name = "iss2731.pdf" writer = PdfWriter(BytesIO(get_data_from_url(url, name=name))) writer.update_page_form_field_values( writer.pages[0], {"Stellenbezeichnung_1": "some filled in text"}, auto_regenerate=False, ) assert "/Matrix" in writer.pages[0]["/Annots"][5].get_object()["/AP"]["/N"] @pytest.mark.enable_socket def test_compress_identical_objects(): """Cf #2728 and #2794""" url = "https://github.com/user-attachments/files/16575458/tt2.pdf" name = "iss2794.pdf" in_bytes = BytesIO(get_data_from_url(url, name=name)) writer = PdfWriter(in_bytes) writer.compress_identical_objects(remove_orphans=False) out1 = BytesIO() writer.write(out1) assert 0.5 * len(in_bytes.getvalue()) > len(out1.getvalue()) writer.remove_page( 1 ) # page0 contains fields which keep reference to the deleted page out2 = BytesIO() writer.write(out2) assert len(out1.getvalue()) - 100 < len(out2.getvalue()) writer.compress_identical_objects(remove_identicals=False) out3 = BytesIO() writer.write(out3) assert len(out2.getvalue()) > len(out3.getvalue()) def test_set_need_appearances_writer(): """Minimal test for coverage""" writer = PdfWriter() writer.set_need_appearances_writer() def test_utf16_metadata(): """See #2754""" writer = PdfWriter(RESOURCE_ROOT / "crazyones.pdf") writer.add_metadata( { "/Subject": "Invoice â„–AI_047", } ) b = BytesIO() writer.write(b) b.seek(0) reader = PdfReader(b) assert reader.metadata.subject == "Invoice â„–AI_047" bb = b.getvalue() i = bb.find(b"/Subject") assert bb[i : i + 100] == ( b"/Subject (\\376\\377\\000I\\000n\\000v\\000o\\000i\\000c\\000e" b"\\000 \\041\\026\\000A\\000I\\000\\137\\0000\\0004\\0007)" ) @pytest.mark.enable_socket def test_increment_writer(caplog): """Tests for #2811""" writer = PdfWriter( RESOURCE_ROOT / "Seige_of_Vicksburg_Sample_OCR-crazyones-merged.pdf", incremental=True, ) # Contains JBIG2 not decoded for the moment assert writer.list_objects_in_increment() == [] # no flowdown of properties # test writing with empty increment b = BytesIO() writer.write(b) with open( RESOURCE_ROOT / "Seige_of_Vicksburg_Sample_OCR-crazyones-merged.pdf", "rb" ) as f: assert b.getvalue() == f.read(-1) b.seek(0) writer2 = PdfWriter(b, incremental=True) assert len([x for x in writer2._objects if x is not None]) == len( [x for x in writer._objects if x is not None] ) writer2.add_metadata({"/Author": "test"}) assert len(writer2.list_objects_in_increment()) == 1 b = BytesIO() writer2.write(b) # modify one object writer.pages[0][NameObject("/MediaBox")] = ArrayObject( [NumberObject(0), NumberObject(0), NumberObject(864), NumberObject(648)] ) assert writer.list_objects_in_increment() == [IndirectObject(4, 0, writer)] b = BytesIO() writer.write(b) writer.pages[5][NameObject("/MediaBox")] = ArrayObject( [NumberObject(0), NumberObject(0), NumberObject(864), NumberObject(648)] ) assert len(writer.list_objects_in_increment()) == 2 # modify object IndirectObject(5,0) : for coverage writer.get_object(5)[NameObject("/ForTestOnly")] = NameObject("/ForTestOnly") b = BytesIO() writer.write(b) assert b.getvalue().startswith(writer._reader.stream.getvalue()) b.seek(0) reader = PdfReader(b) assert reader.pages[0]["/MediaBox"] == ArrayObject( [NumberObject(0), NumberObject(0), NumberObject(864), NumberObject(648)] ) assert "/ForTestOnly" in reader.get_object(5) with pytest.raises(PyPdfError): writer = PdfWriter(1, incremental=True) b.seek(0) writer = PdfWriter(b, incremental=True) assert writer.list_objects_in_increment() == [] # no flowdown of properties writer = PdfWriter(RESOURCE_ROOT / "crazyones.pdf", incremental=True) # 1 object is modified: page 0 inherits MediaBox so is changed assert len(writer.list_objects_in_increment()) == 1 b = BytesIO() writer.write(b) writer = PdfWriter(RESOURCE_ROOT / "crazyones.pdf", incremental=False) # 1 object is modified: page 0 inherits MediaBox so is changed assert len(writer.list_objects_in_increment()) == len(writer._objects) # insert pages in a tree url = "https://github.com/py-pdf/pypdf/files/13946477/panda.pdf" name = "iss2343b.pdf" writer = PdfWriter(BytesIO(get_data_from_url(url, name=name)), incremental=True) reader = PdfReader(RESOURCE_ROOT / "crazyones.pdf") pg = writer.insert_page(reader.pages[0], 4) assert ( pg.raw_get("/Parent") == writer.root_object["/Pages"]["/Kids"][0].get_object()["/Kids"][0] ) assert pg["/Parent"]["/Count"] == 8 assert writer.root_object["/Pages"]["/Count"] == 285 assert len(writer.flattened_pages) == 285 # clone without info writer = PdfWriter(RESOURCE_ROOT / "missing_info.pdf", incremental=True) assert len(writer.list_objects_in_increment()) == 0 assert writer.metadata is None writer.metadata = {} assert writer.metadata == {} assert len(writer.list_objects_in_increment()) == 1 writer.metadata = None assert len(writer.list_objects_in_increment()) == 0 assert writer.metadata is None b = BytesIO() writer.write(b) @pytest.mark.enable_socket def test_append_pdf_with_dest_without_page(caplog): """Tests for #2842""" url = "https://github.com/user-attachments/files/16990834/test.pdf" name = "iss2842.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() writer.append(reader) assert "/__WKANCHOR_8" not in writer.named_destinations assert len(writer.named_destinations) == 3 @pytest.mark.enable_socket def test_destination_is_nullobject(): """Tests for #2958""" url = "https://github.com/user-attachments/files/17822279/C0.00.-.COVER.SHEET.pdf" name = "iss2958.pdf" source_data = BytesIO(get_data_from_url(url, name=name)) writer = PdfWriter() writer.append(source_data) @pytest.mark.enable_socket def test_destination_page_is_none(): """Tests for #2963""" url = "https://github.com/user-attachments/files/17879461/3.pdf" name = "iss2963.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) writer = PdfWriter() writer.append(reader) def test_stream_not_closed(): """Tests for #2905""" src = RESOURCE_ROOT / "pdflatex-outline.pdf" with NamedTemporaryFile(suffix=".pdf") as tmp: with PdfReader(src) as reader, PdfWriter() as writer: writer.add_page(reader.pages[0]) writer.write(tmp) assert not tmp.file.closed with NamedTemporaryFile(suffix=".pdf") as target: with PdfWriter(target.file) as writer: writer.add_blank_page(100, 100) assert not target.file.closed with open(src, "rb") as fileobj: with PdfWriter(fileobj) as writer: pass assert not fileobj.closed def test_auto_write(tmp_path): """Another test for #2905""" target = tmp_path / "out.pdf" with PdfWriter(target) as writer: writer.add_blank_page(100, 100) assert target.stat().st_size > 0 def test_deprecate_with_as(): """Yet another test for #2905""" with PdfWriter() as writer: with pytest.raises( expected_exception=DeprecationError, match=r"with_as_usage is deprecated and was removed in pypdf 5\.0" ): _ = writer.with_as_usage with pytest.raises( expected_exception=DeprecationError, match=r"with_as_usage is deprecated and was removed in pypdf 5\.0" ): writer.with_as_usage = False # old code allowed setting this, so... @pytest.mark.skipif(GHOSTSCRIPT_BINARY is None, reason="Requires Ghostscript") @pytest.mark.enable_socket def test_inline_image_q_operator_handling(tmp_path): """Test for #2927""" pdf_url = "https://github.com/user-attachments/files/17614880/test_clean.pdf" pdf_name = "iss2927.pdf" pdf_data = BytesIO(get_data_from_url(pdf_url, name=pdf_name)) png_url = "https://github.com/user-attachments/assets/abe16f48-9afa-4179-b1e8-62be27b95c26" png_name = "iss2927.png" expected_png_path = tmp_path / "expected.png" expected_png_path.write_bytes(get_data_from_url(png_url, name=png_name)) writer = PdfWriter() writer.append(pdf_data) for page in writer.pages: page.transfer_rotation_to_content() pdf_path = tmp_path / "out.pdf" png_path = tmp_path / "actual.png" writer.write(pdf_path) # False positive: https://github.com/PyCQA/bandit/issues/333 subprocess.run( # noqa: S603 [ GHOSTSCRIPT_BINARY, "-r120", "-sDEVICE=pngalpha", "-o", png_path, pdf_path, ] ) assert png_path.is_file() assert image_similarity(png_path, expected_png_path) >= 0.99999 def test_insert_filtered_annotations__annotations_are_none(): writer = PdfWriter() writer.add_blank_page(72, 72) stream = BytesIO() writer.write(stream) reader = PdfReader(stream) assert writer._insert_filtered_annotations( annots=None, page=PageObject(), pages={}, reader=reader ) == [] def test_incremental_read(): """Test for #3116""" writer = PdfWriter() writer.add_blank_page(72, 72) stream0 = BytesIO() writer.write(stream0) reader = PdfReader(stream0) # 1 = Catalog, 2 = Pages, 3 = New Page, 4 = Info, Size == 5 assert reader.trailer["/Size"] == 5 stream0.seek(0, 0) writer = PdfWriter(stream0, incremental=True) assert len(writer._objects) == 4 assert writer._objects[-1] is not None stream1 = BytesIO() writer.write(stream1) # nothing modified, so nothing added = ideal situation assert stream1.getvalue() == stream1.getvalue() stream0.seek(0, 0) writer = PdfWriter(stream0, incremental=True) assert len(writer._objects) == 4 assert writer._objects[-1] is not None writer.add_blank_page(72, 72) assert len(writer._objects) == 5 stream1 = BytesIO() writer.write(stream1) # 2 = Pages, 5 = New Page, 6 = XRef, Size == 7 # XRef is created on write and not counted assert len(writer._objects) == 5 def test_compress_identical_objects__after_remove_images(): """Test for #3237""" writer = PdfWriter(clone_from=RESOURCE_ROOT / "AutoCad_Diagram.pdf") writer.remove_images() writer.compress_identical_objects(remove_identicals=True, remove_orphans=True) def test_merge__process_named_dests__no_dests_in_source_file(): """Test for #3279""" writer = PdfWriter(clone_from=RESOURCE_ROOT / "crazyones.pdf") # Hacky solution to avoid attribute errors. names = DictionaryObject() names.indirect_reference = names writer.root_object[NameObject("/Names")] = names reader = PdfReader(RESOURCE_ROOT / "hello-world.pdf") destination = Destination(title="test.pdf", page=reader.pages[0], fit=Fit("/Fit")) with mock.patch.object(reader, "_get_named_destinations", return_value={"test.pdf": destination}): writer.append(reader) # The page now points to the appended one. assert writer.named_destinations == { "test.pdf": Destination(title="test.pdf", page=writer.pages[1].indirect_reference, fit=Fit("/Fit")) } def test_insert_filtered_annotations__link_without_destination(): """Test for #3211""" writer = PdfWriter(clone_from=RESOURCE_ROOT / "crazyones.pdf") reader = PdfReader(RESOURCE_ROOT / "hello-world.pdf") annotations = [ DictionaryObject({ "/A": DictionaryObject({"/S": NameObject("/GoTo"), "/D": None}), "/BS": {"/S": "/S", "/Type": "/Border", "/W": 0}, "/Border": [0, 0, 0], "/H": "/I", "/Rect": [68.6001, 653.405, 526.2, 671.054], "/StructParent": 9, "/Subtype": NameObject("/Link"), "/Type": NameObject("/Annot") }) ] result = writer._insert_filtered_annotations( annots=annotations, page=writer.pages[0], pages={}, reader=reader ) assert result == [] writer = PdfWriter(clone_from=RESOURCE_ROOT / "crazyones.pdf") del annotations[0]["/A"]["/D"] result = writer._insert_filtered_annotations( annots=annotations, page=writer.pages[0], pages={}, reader=reader ) assert result == [] @pytest.mark.enable_socket def test_insert_filtered_annotations__annotations_are_no_list(caplog): """Tests for #3320""" url = "https://github.com/user-attachments/files/20818089/bugpdf.pdf" name = "issue3320.pdf" source_data = BytesIO(get_data_from_url(url, name=name)) reader = PdfReader(source_data) writer = PdfWriter() writer.append(reader) font_file2 = reader.get_object(36).indirect_reference assert caplog.messages == [ ( f"Expected list of annotations, got {{'/FontFile2': {font_file2!r}, " "'/Descent': -269, '/CapHeight': 714, '/FontWeight': 300, '/FontName': '/JQJGLF+OpenSans-Light', " "'/ItalicAngle': 0, '/StemV': 48, '/Type': '/FontDescriptor', '/FontBBox': [-521, -269, 1140, 1048], " "'/FontFamily': 'Open Sans Light', '/Flags': 32, '/XHeight': 531, '/Ascent': 1048, '/FontStretch': " "'/Normal'} of type DictionaryObject." ) ] def test_unterminated_object__with_incremental_writer(): """Test for #3118""" reader = PdfReader(RESOURCE_ROOT / "bytes.pdf") writer = PdfWriter(reader, incremental=True) writer.add_blank_page(72, 72) fi = BytesIO() writer.write(fi) b = fi.getvalue() assert b[-39:] == b"\nendstream\nendobj\nstartxref\n1240\n%%EOF\n" def test_wrong_size_in_incremental_pdf(caplog): source_data = RESOURCE_ROOT.joinpath("crazyones.pdf").read_bytes() writer = PdfWriter(BytesIO(source_data), incremental=True) writer._add_object(DictionaryObject()) incremental_data = BytesIO() writer.write(incremental_data) modified_data = incremental_data.getvalue().replace(b"/Size 25", b"/Size 2") writer = PdfWriter(BytesIO(modified_data), incremental=False) assert "Object count 19 exceeds defined trailer size 2" in caplog.text assert len(writer._objects) == 20 caplog.clear() writer = PdfWriter(incremental=False) writer.strict = True with pytest.raises(expected_exception=PdfReadError, match=r"^Object count 19 exceeds defined trailer size 2$"): writer.clone_reader_document_root(reader=PdfReader(BytesIO(modified_data))) with pytest.raises(expected_exception=PdfReadError, match=r"^Got index error while flattening\.$"): PdfWriter(BytesIO(modified_data), incremental=True) pypdf-6.1.2/tests/test_xmp.py000066400000000000000000000723461507516550200162430ustar00rootroot00000000000000"""Test the pypdf.xmp module.""" from datetime import datetime, timedelta, timezone from io import BytesIO from pathlib import Path import pytest import pypdf.generic import pypdf.xmp from pypdf import PdfReader, PdfWriter from pypdf.errors import PdfReadError, XmpDocumentError from pypdf.generic import NameObject, StreamObject from pypdf.xmp import XmpInformation from . import get_data_from_url TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" SAMPLE_ROOT = Path(PROJECT_ROOT) / "sample-files" @pytest.mark.samples @pytest.mark.parametrize( "src", [ (SAMPLE_ROOT / "020-xmp/output_with_metadata_pymupdf.pdf"), ], ) def test_read_xmp_metadata_samples(src): reader = PdfReader(src) xmp = reader.xmp_metadata assert xmp assert xmp.dc_contributor == [] assert xmp.dc_creator == ["John Doe"] assert xmp.dc_source == "Martin Thoma" # attribute node assert xmp.dc_description == {"x-default": "This is a text"} assert xmp.dc_date == [datetime(1990, 4, 28, 0, 0)] assert xmp.dc_title == {"x-default": "Sample PDF with XMP Metadata"} assert xmp.custom_properties == { "Style": "FooBarStyle", "other": "worlds", "⏰": "time", } @pytest.mark.samples def test_writer_xmp_metadata_samples(): writer = PdfWriter(SAMPLE_ROOT / "020-xmp/output_with_metadata_pymupdf.pdf") xmp = writer.xmp_metadata assert xmp assert xmp.dc_contributor == [] assert xmp.dc_creator == ["John Doe"] assert xmp.dc_source == "Martin Thoma" # attribute node assert xmp.dc_description == {"x-default": "This is a text"} assert xmp.dc_date == [datetime(1990, 4, 28, 0, 0)] assert xmp.dc_title == {"x-default": "Sample PDF with XMP Metadata"} assert xmp.custom_properties == { "Style": "FooBarStyle", "other": "worlds", "⏰": "time", } co = pypdf.generic.ContentStream(None, None) co.set_data( xmp.stream.get_data().replace( b'dc:source="Martin Thoma"', b'dc:source="Pubpub-Zz"' ) ) writer.xmp_metadata = pypdf.xmp.XmpInformation(co) b = BytesIO() writer.write(b) reader = PdfReader(b) xmp2 = reader.xmp_metadata assert xmp2.dc_source == "Pubpub-Zz" @pytest.mark.parametrize( ("src", "has_xmp"), [ (RESOURCE_ROOT / "commented-xmp.pdf", True), (RESOURCE_ROOT / "crazyones.pdf", False), ], ) def test_read_xmp_metadata(src, has_xmp): """Read XMP metadata from PDF files.""" reader = PdfReader(src) xmp = reader.xmp_metadata assert (xmp is None) == (not has_xmp) if has_xmp: for _ in xmp.get_element( about_uri="", namespace=pypdf.xmp.RDF_NAMESPACE, name="Artist" ): pass assert get_all_tiff(xmp) == {"tiff:Artist": ["me"]} assert xmp.dc_contributor == [] def get_all_tiff(xmp: pypdf.xmp.XmpInformation): """Return all TIFF metadata as a dictionary.""" data = {} tiff_ns = xmp.get_nodes_in_namespace( about_uri="", namespace="http://ns.adobe.com/tiff/1.0/" ) for tag in tiff_ns: contents = [content.data for content in tag.childNodes] data[tag.tagName] = contents return data def test_converter_date(): """ _converter_date returns the correct datetime. This is a regression test for issue #774. """ date = pypdf.xmp._converter_date("2021-04-28T12:23:34.123Z") assert date == datetime(2021, 4, 28, 12, 23, 34, 123000) with pytest.raises(ValueError) as exc: pypdf.xmp._converter_date("today") assert exc.value.args[0].startswith("Invalid date format") date = pypdf.xmp._converter_date("2021-04-28T12:23:01-03:00") assert date == datetime(2021, 4, 28, 15, 23, 1) def test_modify_date(): """ xmp_modify_date is extracted correctly. This is a regression test for issue #914. """ path = RESOURCE_ROOT / "issue-914-xmp-data.pdf" reader = PdfReader(path) assert reader.xmp_metadata.xmp_modify_date == datetime(2022, 4, 9, 15, 22, 43) @pytest.mark.parametrize( "x", ["a", 42, 3.141, False, True], ) def test_identity_function(x): """The identity is returning its input.""" assert pypdf.xmp._identity(x) == x @pytest.mark.enable_socket @pytest.mark.parametrize( ("url", "name", "xmpmm_instance_id"), [ ( None, "tika-955562.pdf", "uuid:ca96e032-c2af-49bd-a71c-95889bafbf1d", ) ], ) def test_xmpmm_instance_id(url, name, xmpmm_instance_id): """XMPMM instance id is correctly extracted.""" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) xmp_metadata = reader.xmp_metadata assert xmp_metadata.xmpmm_instance_id == xmpmm_instance_id # cache hit: assert xmp_metadata.xmpmm_instance_id == xmpmm_instance_id @pytest.mark.enable_socket def test_xmp_dc_description_extraction(): """XMP dc_description is correctly extracted.""" url = "https://github.com/user-attachments/files/18381721/tika-953770.pdf" name = "tika-953770.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) xmp_metadata = reader.xmp_metadata assert xmp_metadata.dc_description == { "x-default": "U.S. Title 50 Certification Form" } # cache hit: assert xmp_metadata.dc_description == { "x-default": "U.S. Title 50 Certification Form" } @pytest.mark.enable_socket def test_dc_creator_extraction(): """XMP dc_creator is correctly extracted.""" url = "https://github.com/user-attachments/files/18381721/tika-953770.pdf" name = "tika-953770.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) xmp_metadata = reader.xmp_metadata assert xmp_metadata.dc_creator == ["U.S. Fish and Wildlife Service"] # cache hit: assert xmp_metadata.dc_creator == ["U.S. Fish and Wildlife Service"] @pytest.mark.enable_socket def test_custom_properties_extraction(): """XMP custom_properties is correctly extracted.""" url = "https://github.com/user-attachments/files/18381764/tika-986065.pdf" name = "tika-986065.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) xmp_metadata = reader.xmp_metadata assert xmp_metadata.custom_properties == {"Style": "Searchable Image (Exact)"} # cache hit: assert xmp_metadata.custom_properties == {"Style": "Searchable Image (Exact)"} @pytest.mark.enable_socket def test_dc_subject_extraction(): """XMP dc_subject is correctly extracted.""" url = "https://github.com/user-attachments/files/18381730/tika-959519.pdf" name = "tika-959519.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) xmp_metadata = reader.xmp_metadata assert xmp_metadata.dc_subject == [ "P&P", "manual", "1240.2325", "CVM", "PROCEDURES ON MEDIA INQUIRIES", "animal", "media", "procedures", "inquiries", ] # Cache hit: assert xmp_metadata.dc_subject == [ "P&P", "manual", "1240.2325", "CVM", "PROCEDURES ON MEDIA INQUIRIES", "animal", "media", "procedures", "inquiries", ] @pytest.mark.enable_socket def test_invalid_xmp_information_handling(): """ Invalid XML in xmp_metadata is gracefully handled. This is a regression test for issue #585. """ url = "https://github.com/py-pdf/pypdf/files/5536984/test.pdf" name = "pypdf-5536984.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) with pytest.raises(PdfReadError) as exc: reader.xmp_metadata assert exc.value.args[0].startswith("XML in XmpInformation was invalid") @pytest.mark.samples def test_pdfa_xmp_metadata_with_values(): """Test PDF/A XMP metadata extraction from a file with PDF/A metadata.""" reader = PdfReader(SAMPLE_ROOT / "021-pdfa" / "crazyones-pdfa.pdf") xmp = reader.xmp_metadata assert xmp is not None assert xmp.pdfaid_part == "1" assert xmp.pdfaid_conformance == "B" @pytest.mark.samples def test_pdfa_xmp_metadata_without_values(): """Test PDF/A XMP metadata extraction from a file without PDF/A metadata.""" reader = PdfReader(SAMPLE_ROOT / "020-xmp" / "output_with_metadata_pymupdf.pdf") xmp = reader.xmp_metadata assert xmp is not None assert xmp.pdfaid_part is None assert xmp.pdfaid_conformance is None @pytest.mark.enable_socket def test_xmp_metadata__content_stream_is_dictionary_object(): url = "https://github.com/user-attachments/files/18943249/testing.pdf" name = "issue3107.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) with pytest.raises( PdfReadError, match="XML in XmpInformation was invalid: 'DictionaryObject' object has no attribute 'get_data'" ): assert reader.xmp_metadata is not None @pytest.mark.enable_socket def test_dc_creator__bag_instead_of_seq(): url = "https://github.com/user-attachments/files/18381698/tika-924562.pdf" name = "tika-924562.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) assert reader.xmp_metadata is not None assert reader.xmp_metadata.dc_creator == ["William J. Hussar"] @pytest.mark.enable_socket def test_dc_language__no_bag_container(): reader = PdfReader(BytesIO(get_data_from_url(name="iss2138.pdf"))) assert reader.xmp_metadata is not None assert reader.xmp_metadata.dc_language == ["x-unknown"] def test_reading_does_not_destroy_root_object(): """Test for #3391.""" writer = PdfWriter(clone_from=RESOURCE_ROOT / "commented-xmp.pdf") xmp = writer.xmp_metadata assert xmp is not None assert not isinstance(writer.root_object["/Metadata"], XmpInformation) assert isinstance(writer.root_object["/Metadata"].get_object(), StreamObject) output = BytesIO() writer.write(output) output_bytes = output.getvalue() assert b"\n/Metadata 27 0 R\n" in output_bytes def test_xmp_information__write_to_stream(): writer = PdfWriter(clone_from=RESOURCE_ROOT / "commented-xmp.pdf") xmp = writer.xmp_metadata output = BytesIO() with pytest.warns( DeprecationWarning, match=( r"^XmpInformation\.write_to_stream is deprecated and will be removed in pypdf 6\.0\.0\. " r"Use PdfWriter\.xmp_metadata instead\.$" ) ): xmp.write_to_stream(output) output_bytes = output.getvalue() assert output_bytes.startswith(b"<<\n/Type /Metadata\n/Subtype /XML\n/Length 2786\n>>\nstream\nme", b"Foo Bar") xmp_metadata.stream.set_data(new_metadata) output = BytesIO() writer.write(output) output_bytes = output.getvalue() reader = PdfReader(BytesIO(output_bytes)) assert get_all_tiff(reader.xmp_metadata) == {"tiff:Artist": ["Foo Bar"]} # Fix metadata not being an IndirectObject before. writer = PdfWriter(clone_from=RESOURCE_ROOT / "commented-xmp.pdf") writer.root_object[NameObject("/Metadata")] = writer.root_object["/Metadata"].get_object() assert "/XML" in str(writer.root_object) writer.xmp_metadata = new_metadata output = BytesIO() writer.write(output) output_bytes = output.getvalue() reader = PdfReader(BytesIO(output_bytes)) assert get_all_tiff(reader.xmp_metadata) == {"tiff:Artist": ["Foo Bar"]} assert "/XML" not in str(writer.root_object) def test_xmp_information__create(): """Test XmpInformation.create() classmethod.""" xmp = XmpInformation.create() assert xmp is not None assert xmp.dc_title == {} assert xmp.dc_creator == [] assert xmp.dc_description == {} assert xmp.xmp_create_date is None assert xmp.pdf_producer is None def test_xmp_information__set_dc_title(): """Test setting dc:title metadata.""" xmp = XmpInformation.create() title_values = {"x-default": "Test Title", "en": "Test Title EN"} xmp.dc_title = title_values assert xmp.dc_title == title_values xmp.dc_title = None assert xmp.dc_title is None or xmp.dc_title == {} def test_xmp_information__set_dc_creator(): """Test setting dc:creator metadata.""" xmp = XmpInformation.create() creators = ["Author One", "Author Two"] xmp.dc_creator = creators assert xmp.dc_creator == creators xmp.dc_creator = None assert xmp.dc_creator is None or xmp.dc_creator == [] def test_xmp_information__set_dc_description(): """Test setting dc:description metadata.""" xmp = XmpInformation.create() description_values = {"x-default": "Test Description", "en": "Test Description EN"} xmp.dc_description = description_values assert xmp.dc_description == description_values xmp.dc_description = None assert xmp.dc_description is None or xmp.dc_description == {} def test_xmp_information__set_dc_subject(): """Test setting dc:subject metadata.""" xmp = XmpInformation.create() subjects = ["keyword1", "keyword2", "keyword3"] xmp.dc_subject = subjects assert xmp.dc_subject == subjects xmp.dc_subject = None assert xmp.dc_subject is None or xmp.dc_subject == [] def test_xmp_information__set_dc_date(): """Test setting dc:date metadata.""" xmp = XmpInformation.create() test_date = datetime(2023, 12, 25, 10, 30, 45) xmp.dc_date = [test_date] stored_dates = xmp.dc_date assert len(stored_dates) == 1 date_string = "2023-12-25T10:30:45.000000Z" xmp.dc_date = [date_string] stored_dates = xmp.dc_date assert len(stored_dates) == 1 xmp.dc_date = None assert xmp.dc_date is None or xmp.dc_date == [] def test_xmp_information__set_single_fields(): """Test setting single-value metadata fields.""" xmp = XmpInformation.create() xmp.dc_coverage = "Global coverage" assert xmp.dc_coverage == "Global coverage" xmp.dc_coverage = None assert xmp.dc_coverage is None xmp.dc_format = "application/pdf" assert xmp.dc_format == "application/pdf" xmp.dc_format = None assert xmp.dc_format is None xmp.dc_identifier = "unique-id-123" assert xmp.dc_identifier == "unique-id-123" xmp.dc_identifier = None assert xmp.dc_identifier is None xmp.dc_source = "Original Source" assert xmp.dc_source == "Original Source" xmp.dc_source = None assert xmp.dc_source is None def test_xmp_information__set_bag_fields(): """Test setting bag (unordered array) metadata fields.""" xmp = XmpInformation.create() contributors = ["Contributor One", "Contributor Two"] xmp.dc_contributor = contributors assert xmp.dc_contributor == contributors xmp.dc_contributor = None assert xmp.dc_contributor is None or xmp.dc_contributor == [] languages = ["en", "fr", "de"] xmp.dc_language = languages assert xmp.dc_language == languages xmp.dc_language = None assert xmp.dc_language is None or xmp.dc_language == [] publishers = ["Publisher One", "Publisher Two"] xmp.dc_publisher = publishers assert xmp.dc_publisher == publishers xmp.dc_publisher = None assert xmp.dc_publisher is None or xmp.dc_publisher == [] relations = ["Related Doc 1", "Related Doc 2"] xmp.dc_relation = relations assert xmp.dc_relation == relations xmp.dc_relation = None assert xmp.dc_relation is None or xmp.dc_relation == [] types = ["Document", "Text"] xmp.dc_type = types assert xmp.dc_type == types xmp.dc_type = None assert xmp.dc_type is None or xmp.dc_type == [] def test_xmp_information__set_dc_rights(): """Test setting dc:rights metadata.""" xmp = XmpInformation.create() rights_values = {"x-default": "All rights reserved", "en": "All rights reserved EN"} xmp.dc_rights = rights_values assert xmp.dc_rights == rights_values xmp.dc_rights = None assert xmp.dc_rights is None or xmp.dc_rights == {} def test_xmp_information__set_pdf_fields(): """Test setting PDF namespace metadata fields.""" xmp = XmpInformation.create() xmp.pdf_keywords = "keyword1, keyword2, keyword3" assert xmp.pdf_keywords == "keyword1, keyword2, keyword3" xmp.pdf_keywords = None assert xmp.pdf_keywords is None xmp.pdf_pdfversion = "1.4" assert xmp.pdf_pdfversion == "1.4" xmp.pdf_pdfversion = None assert xmp.pdf_pdfversion is None xmp.pdf_producer = "pypdf" assert xmp.pdf_producer == "pypdf" xmp.pdf_producer = None assert xmp.pdf_producer is None def test_xmp_information__set_xmp_date_fields(): """Test setting XMP date metadata fields.""" xmp = XmpInformation.create() test_date = datetime(2023, 12, 25, 10, 30, 45) aware_date = datetime(2023, 1, 1, 12, 0, 0, tzinfo=timezone(timedelta(hours=-5))) xmp.xmp_create_date = test_date stored_date = xmp.xmp_create_date assert isinstance(stored_date, datetime) xmp.xmp_create_date = aware_date stored_date = xmp.xmp_create_date assert stored_date == datetime(2023, 1, 1, 17, 0, 0) xmp.xmp_create_date = None assert xmp.xmp_create_date is None xmp.xmp_modify_date = test_date stored_date = xmp.xmp_modify_date assert isinstance(stored_date, datetime) xmp.xmp_modify_date = aware_date stored_date = xmp.xmp_modify_date assert stored_date == datetime(2023, 1, 1, 17, 0, 0) xmp.xmp_modify_date = None assert xmp.xmp_modify_date is None xmp.xmp_metadata_date = test_date stored_date = xmp.xmp_metadata_date assert isinstance(stored_date, datetime) xmp.xmp_metadata_date = aware_date stored_date = xmp.xmp_metadata_date assert stored_date == datetime(2023, 1, 1, 17, 0, 0) xmp.xmp_metadata_date = None assert xmp.xmp_metadata_date is None def test_xmp_information__set_xmp_creator_tool(): """Test setting xmp:CreatorTool metadata.""" xmp = XmpInformation.create() xmp.xmp_creator_tool = "pypdf" assert xmp.xmp_creator_tool == "pypdf" xmp.xmp_creator_tool = None assert xmp.xmp_creator_tool is None def test_xmp_information__set_xmpmm_fields(): """Test setting XMPMM namespace metadata fields.""" xmp = XmpInformation.create() doc_id = "uuid:12345678-1234-1234-1234-123456789abc" xmp.xmpmm_document_id = doc_id assert xmp.xmpmm_document_id == doc_id xmp.xmpmm_document_id = None assert xmp.xmpmm_document_id is None instance_id = "uuid:87654321-4321-4321-4321-cba987654321" xmp.xmpmm_instance_id = instance_id assert xmp.xmpmm_instance_id == instance_id xmp.xmpmm_instance_id = None assert xmp.xmpmm_instance_id is None def test_xmp_information__set_pdfaid_fields(): """Test setting PDF/A ID namespace metadata fields.""" xmp = XmpInformation.create() xmp.pdfaid_part = "1" assert xmp.pdfaid_part == "1" xmp.pdfaid_part = None assert xmp.pdfaid_part is None xmp.pdfaid_conformance = "B" assert xmp.pdfaid_conformance == "B" xmp.pdfaid_conformance = None assert xmp.pdfaid_conformance is None def test_xmp_information__create_with_writer(): """Test using XmpInformation.create() with PdfWriter.""" xmp = XmpInformation.create() xmp.dc_title = {"x-default": "Created with pypdf"} xmp.dc_creator = ["pypdf user"] xmp.pdf_producer = "pypdf library" writer = PdfWriter() writer.add_blank_page(612, 792) writer.xmp_metadata = xmp output = BytesIO() writer.write(output) output_bytes = output.getvalue() reader = PdfReader(BytesIO(output_bytes)) xmp_read = reader.xmp_metadata assert xmp_read is not None assert xmp_read.dc_title == {"x-default": "Created with pypdf"} assert xmp_read.dc_creator == ["pypdf user"] assert xmp_read.pdf_producer == "pypdf library" def test_xmp_information__namespace_prefix(): """Test _get_namespace_prefix method.""" xmp = XmpInformation.create() assert xmp._get_namespace_prefix(pypdf.xmp.DC_NAMESPACE) == "dc" assert xmp._get_namespace_prefix(pypdf.xmp.XMP_NAMESPACE) == "xmp" assert xmp._get_namespace_prefix(pypdf.xmp.PDF_NAMESPACE) == "pdf" assert xmp._get_namespace_prefix(pypdf.xmp.XMPMM_NAMESPACE) == "xmpMM" assert xmp._get_namespace_prefix(pypdf.xmp.PDFAID_NAMESPACE) == "pdfaid" assert xmp._get_namespace_prefix(pypdf.xmp.PDFX_NAMESPACE) == "pdfx" assert xmp._get_namespace_prefix("unknown://namespace") == "unknown" def test_xmp_information__owner_document_none_errors(): xmp = XmpInformation.create() original_owner = xmp.rdf_root.ownerDocument try: for desc in list(xmp.rdf_root.getElementsByTagNameNS(pypdf.xmp.RDF_NAMESPACE, "Description")): xmp.rdf_root.removeChild(desc) xmp.rdf_root.ownerDocument = None with pytest.raises(XmpDocumentError, match="XMP Document is None"): xmp._get_or_create_description() with pytest.raises(XmpDocumentError, match="XMP Document is None"): xmp._update_stream() xmp.rdf_root.ownerDocument = original_owner for desc in list(xmp.rdf_root.getElementsByTagNameNS(pypdf.xmp.RDF_NAMESPACE, "Description")): xmp.rdf_root.removeChild(desc) xmp.rdf_root.ownerDocument = None with pytest.raises(XmpDocumentError, match="XMP Document is None"): xmp.dc_coverage = "test coverage" xmp.rdf_root.ownerDocument = original_owner for desc in list(xmp.rdf_root.getElementsByTagNameNS(pypdf.xmp.RDF_NAMESPACE, "Description")): xmp.rdf_root.removeChild(desc) xmp.rdf_root.ownerDocument = None with pytest.raises(XmpDocumentError, match="XMP Document is None"): xmp.dc_contributor = ["contributor"] xmp.rdf_root.ownerDocument = original_owner for desc in list(xmp.rdf_root.getElementsByTagNameNS(pypdf.xmp.RDF_NAMESPACE, "Description")): xmp.rdf_root.removeChild(desc) xmp.rdf_root.ownerDocument = None with pytest.raises(XmpDocumentError, match="XMP Document is None"): xmp.dc_creator = ["creator"] xmp.rdf_root.ownerDocument = original_owner for desc in list(xmp.rdf_root.getElementsByTagNameNS(pypdf.xmp.RDF_NAMESPACE, "Description")): xmp.rdf_root.removeChild(desc) xmp.rdf_root.ownerDocument = None with pytest.raises(XmpDocumentError, match="XMP Document is None"): xmp.dc_title = {"x-default": "title"} xmp.rdf_root.ownerDocument = original_owner desc = xmp._get_or_create_description() desc.setAttribute("test-attr", "test-value") xmp.rdf_root.ownerDocument = None with pytest.raises(XmpDocumentError, match="XMP Document is None"): xmp._set_single_value("test-namespace", "test-attr", "new-value") xmp.rdf_root.ownerDocument = original_owner desc = xmp._get_or_create_description() xmp.rdf_root.ownerDocument = None with pytest.raises(XmpDocumentError, match="XMP Document is None"): xmp._set_bag_values("test-namespace", "test-name", ["value"]) xmp.rdf_root.ownerDocument = original_owner desc = xmp._get_or_create_description() xmp.rdf_root.ownerDocument = None with pytest.raises(XmpDocumentError, match="XMP Document is None"): xmp._set_seq_values("test-namespace", "test-name", ["value"]) xmp.rdf_root.ownerDocument = original_owner desc = xmp._get_or_create_description() xmp.rdf_root.ownerDocument = None with pytest.raises(XmpDocumentError, match="XMP Document is None"): xmp._set_langalt_values("test-namespace", "test-name", {"x-default": "value"}) finally: xmp.rdf_root.ownerDocument = original_owner def test_xmp_information__remove_existing_attribute(): xmp = XmpInformation.create() xmp.dc_coverage = "initial coverage" assert xmp.dc_coverage == "initial coverage" xmp.dc_coverage = "updated coverage" assert xmp.dc_coverage == "updated coverage" xmp.dc_coverage = None assert xmp.dc_coverage is None desc = xmp._get_or_create_description() desc.setAttributeNS(pypdf.xmp.DC_NAMESPACE, "dc:coverage", "original attribute") assert desc.getAttributeNS(pypdf.xmp.DC_NAMESPACE, "coverage") == "original attribute" xmp.dc_coverage = "new element value" assert xmp.dc_coverage == "new element value" assert desc.getAttributeNS(pypdf.xmp.DC_NAMESPACE, "coverage") == "" elements = desc.getElementsByTagNameNS(pypdf.xmp.DC_NAMESPACE, "coverage") assert len(elements) == 1 assert elements[0].firstChild.data == "new element value" def test_xmp_information__edge_case_coverage(): xmp = XmpInformation.create() xmp.dc_contributor = [] assert xmp.dc_contributor == [] xmp.dc_creator = [] assert xmp.dc_creator == [] xmp.dc_title = {} assert xmp.dc_title == {} xmp.dc_contributor = None assert xmp.dc_contributor == [] xmp.dc_creator = None assert xmp.dc_creator == [] xmp.dc_title = None assert xmp.dc_title == {} def test_xmp_information__create_new_description(): """Test creating new description elements.""" xmp = XmpInformation.create() for desc in list(xmp.rdf_root.getElementsByTagNameNS(pypdf.xmp.RDF_NAMESPACE, "Description")): xmp.rdf_root.removeChild(desc) desc = xmp._get_or_create_description("test-uri") assert desc.getAttributeNS(pypdf.xmp.RDF_NAMESPACE, "about") == "test-uri" assert desc.tagName == "rdf:Description" assert desc.namespaceURI == pypdf.xmp.RDF_NAMESPACE def test_xmp_information__get_text_skips_non_text_nodes(): xmp = XmpInformation.create() doc = xmp.rdf_root.ownerDocument el = doc.createElementNS(pypdf.xmp.DC_NAMESPACE, "dc:test") el.appendChild(doc.createTextNode("hello")) el.appendChild(doc.createElement("ignored-node")) el.appendChild(doc.createTextNode(" world")) assert xmp._get_text(el) == "hello world" def test_xmp_information__get_or_create_description_mismatch_about_uri(): xmp = XmpInformation.create() existing = xmp._get_or_create_description() existing.setAttributeNS(pypdf.xmp.RDF_NAMESPACE, "rdf:about", "foo-uri") new_desc = xmp._get_or_create_description("bar-uri") assert new_desc is not existing assert new_desc.getAttributeNS(pypdf.xmp.RDF_NAMESPACE, "about") == "bar-uri" all_desc = list(xmp.rdf_root.getElementsByTagNameNS(pypdf.xmp.RDF_NAMESPACE, "Description")) about_values = {d.getAttributeNS(pypdf.xmp.RDF_NAMESPACE, "about") for d in all_desc} assert {"foo-uri", "bar-uri"}.issubset(about_values) def test_xmp_information__attribute_handling(): """Test attribute node removal and creation (line 479, 484, 506, 535, 564).""" xmp = XmpInformation.create() for desc in list(xmp.rdf_root.getElementsByTagNameNS(pypdf.xmp.RDF_NAMESPACE, "Description")): xmp.rdf_root.removeChild(desc) xmp.dc_coverage = "test coverage" assert xmp.dc_coverage == "test coverage" xmp.dc_contributor = ["contributor1", "contributor2"] assert xmp.dc_contributor == ["contributor1", "contributor2"] xmp.dc_creator = ["creator1", "creator2"] assert xmp.dc_creator == ["creator1", "creator2"] xmp.dc_title = {"x-default": "Test Title", "en": "Test Title EN"} assert xmp.dc_title == {"x-default": "Test Title", "en": "Test Title EN"} xmp.dc_format = "application/pdf" assert xmp.dc_format == "application/pdf" xmp.dc_format = "text/plain" assert xmp.dc_format == "text/plain" def test_xmp_information__create_and_set_metadata(): xmp = XmpInformation.create() for desc in list(xmp.rdf_root.getElementsByTagNameNS(pypdf.xmp.RDF_NAMESPACE, "Description")): xmp.rdf_root.removeChild(desc) desc = xmp._get_or_create_description() desc.setAttribute("test", "value") xmp.dc_source = "original" xmp.dc_source = "modified" assert xmp.dc_source == "modified" for desc in list(xmp.rdf_root.getElementsByTagNameNS(pypdf.xmp.RDF_NAMESPACE, "Description")): xmp.rdf_root.removeChild(desc) xmp.dc_contributor = ["test1"] xmp.dc_creator = ["test2"] xmp.dc_title = {"x-default": "test3"} assert xmp.dc_contributor == ["test1"] assert xmp.dc_creator == ["test2"] assert xmp.dc_title == {"x-default": "test3"} pypdf-6.1.2/tests/test_xobject_image_helpers.py000066400000000000000000000124001507516550200217420ustar00rootroot00000000000000"""Test the pypdf._xobj_image_helpers module.""" from io import BytesIO from pathlib import Path import pytest from pypdf import PdfReader from pypdf._xobj_image_helpers import _extended_image_frombytes, _handle_flate from pypdf.errors import EmptyImageDataError, PdfReadError from pypdf.generic import ArrayObject, DecodedStreamObject, NameObject, NumberObject from . import get_data_from_url TESTS_ROOT = Path(__file__).parent.resolve() PROJECT_ROOT = TESTS_ROOT.parent RESOURCE_ROOT = PROJECT_ROOT / "resources" @pytest.mark.enable_socket def test_get_imagemode_recursion_depth(): """Avoid infinite recursion for nested color spaces.""" url = "https://github.com/py-pdf/pypdf/files/12814018/out1.pdf" name = "issue2240.pdf" # Simple example: Just let the color space object reference itself. # The alternative would be to generate a chain of referencing objects. content = get_data_from_url(url, name=name) source = b"\n10 0 obj\n[ /DeviceN [ /HKS#2044#20K /Magenta /Yellow /Black ] 7 0 R 11 0 R 12 0 R ]\nendobj\n" target = b"\n10 0 obj\n[ /DeviceN [ /HKS#2044#20K /Magenta /Yellow /Black ] 10 0 R 11 0 R 12 0 R ]\nendobj\n" reader = PdfReader(BytesIO(content.replace(source, target))) with pytest.raises( PdfReadError, match=r"Color spaces nested too deeply\. If required, consider increasing MAX_IMAGE_MODE_NESTING_DEPTH\.", ): reader.pages[0].images[0] def test_handle_flate__image_mode_1(caplog): data = b"\x00\xe0\x00" lookup = DecodedStreamObject() expected_data = [ (66, 66, 66), (66, 66, 66), (66, 66, 66), (0, 19, 55), (0, 19, 55), (0, 19, 55), (66, 66, 66), (66, 66, 66), (66, 66, 66), ] # No trailing data. lookup.set_data(b"\x42\x42\x42\x00\x13\x37") result = _handle_flate( size=(3, 3), data=data, mode="1", color_space=ArrayObject( [NameObject("/Indexed"), NameObject("/DeviceRGB"), NumberObject(1), lookup] ), colors=2, obj_as_text="dummy", ) assert expected_data == list(result[0].getdata()) assert not caplog.text # Trailing whitespace. lookup.set_data(b"\x42\x42\x42\x00\x13\x37 \x0a") result = _handle_flate( size=(3, 3), data=data, mode="1", color_space=ArrayObject( [NameObject("/Indexed"), NameObject("/DeviceRGB"), NumberObject(1), lookup] ), colors=2, obj_as_text="dummy", ) assert expected_data == list(result[0].getdata()) assert not caplog.text # Trailing non-whitespace character. lookup.set_data(b"\x42\x42\x42\x00\x13\x37\x12") result = _handle_flate( size=(3, 3), data=data, mode="1", color_space=ArrayObject( [ NameObject("/Indexed"), NameObject("/DeviceRGB"), NumberObject(1), lookup, ] ), colors=2, obj_as_text="dummy", ) assert expected_data == list(result[0].getdata()) assert "Too many lookup values: Expected 6, got 7." in caplog.text # Not enough lookup data. # `\xe0` of the original input (the middle part) does not use `0x37 = 55` for the lookup # here, but received a custom padding of `0`. lookup.set_data(b"\x42\x42\x42\x00\x13") caplog.clear() expected_short_data = [entry if entry[0] == 66 else (0, 19, 0) for entry in expected_data] result = _handle_flate( size=(3, 3), data=data, mode="1", color_space=ArrayObject( [ NameObject("/Indexed"), NameObject("/DeviceRGB"), NumberObject(1), lookup, ] ), colors=2, obj_as_text="dummy", ) assert expected_short_data == list(result[0].getdata()) assert "Not enough lookup values: Expected 6, got 5." in caplog.text def test_extended_image_frombytes_zero_data(): mode = "RGB" size = (1, 1) data = b"" with pytest.raises(EmptyImageDataError, match=r"Data is 0 bytes, cannot process an image from empty data\."): _extended_image_frombytes(mode, size, data) def test_handle_flate__autodesk_indexed(): reader = PdfReader(RESOURCE_ROOT / "AutoCad_Diagram.pdf") page = reader.pages[0] for name, image in page.images.items(): assert name.startswith("/") image.image.load() data = RESOURCE_ROOT.joinpath("AutoCad_Diagram.pdf").read_bytes() data = data.replace(b"/DeviceRGB\x00255", b"/DeviceRGB") reader = PdfReader(BytesIO(data)) page = reader.pages[0] with pytest.raises( PdfReadError, match=r"^Expected color space with 4 values, got 3: \['/Indexed', '/DeviceRGB', '\\x00\\x80\\x00\\x80\\x80耀" # noqa: E501 ): for name, _image in page.images.items(): # noqa: PERF102 assert name.startswith("/") @pytest.mark.enable_socket def test_get_mode_and_invert_color(): url = "https://github.com/user-attachments/files/18381726/tika-957721.pdf" name = "tika-957721.pdf" reader = PdfReader(BytesIO(get_data_from_url(url, name=name))) page = reader.pages[12] for _name, image in page.images.items(): # noqa: PERF102 image.image.load()